title: Early- and late-born parvalbumin basket cell subpopulations exhibiting distinct regulation and roles in learning.
abstract: Brain networks can support learning by promoting acquisition of task-relevant information or by adhering to validated rules, but the mechanisms involved are poorly understood. Upon learning, local inhibitory parvalbumin (PV)-expressing Basket cell networks can switch to opposite configurations that either favor or interfere with further learning, but how this opposite plasticity is induced and relates to distinct learning requirements has remained unclear. Here, we show that PV Basket cells consist of hitherto unrecognized subpopulations, with distinct schedules of neurogenesis, input connectivities, output target neurons, and roles in learning. Plasticity of hippocampal early-born PV neurons was recruited in rule consolidation, whereas plasticity of late-born PV neurons was recruited in new information acquisition. This involved regulation of early-born neuron plasticity specifically through excitation, and of late-born neuron plasticity specifically through inhibition. Therefore, opposite learning requirements are implemented by distinct local networks involving PV Basket cell subpopulations specifically regulated through inhibition or excitation.
authors.affiliation: Friedrich Miescher Institut, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Flavio
authors.initials: F
authors.lastname: Donato
authors.affiliation: Friedrich Miescher Institut, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Ananya
authors.initials: A
authors.lastname: Chowdhury
authors.affiliation: Friedrich Miescher Institut, Maulbeerstrasse 66, 4058 Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: Lahr
authors.affiliation: Friedrich Miescher Institut, Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address: caroni@fmi.ch.
authors.forename: Pico
authors.initials: P
authors.lastname: Caroni
mesh_terms: D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000494:pharmacology; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D003975:Diazepam / Q000494:pharmacology; D004622:Embryo, Mammalian; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018757:GABA Modulators / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D066298:In Vitro Techniques; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009415:Nerve Net / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018757:GABA Modulators; D010320:Parvalbumins; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D003975:Diazepam