title: In vitro anti-oxidant potential of new metabolites from Hypericum oblongifolium (Guttiferae).
abstract: Phytochemical investigations on Hypericum oblongifolium led to the isolation of a flavone named folicitin (1) and a bicyclic conjugated lactone, folenolide (2) from the ethyl acetate fraction of methanolic extract. Both metabolites were characterised as new compounds based on detailed spectroscopic analyses. In vitro anti-oxidant potential of both the compounds was evaluated by the DPPH radical scavenging assay. Compound 1 exhibited significant antioxidant activity while compound 2 was found inactive.
authors.affiliation: a Department of Pharmacy , University of Peshawar , Peshawar 25120 , Pakistan.|b Department of Pharmacy , Sarhad University of Science and Information Technology , Peshawar , Pakistan.
authors.forename: Naila
authors.initials: N
authors.lastname: Raziq
authors.affiliation: a Department of Pharmacy , University of Peshawar , Peshawar 25120 , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saeed
authors.affiliation: c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270 , Pakistan.
authors.forename: Muhammad Shaiq
authors.initials: MS
authors.lastname: Ali
authors.affiliation: d Institute of Chemical Sciences, University of Peshawar , Peshawar 25120 , Pakistan.
authors.forename: Salman
authors.initials: S
authors.lastname: Zafar
authors.affiliation: c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi , Karachi 75270 , Pakistan.|e Govt. Degree Boys College , Nishtar Road, Karachi , Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Ali
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D020902:Hypericum / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D047309:Flavones; D007783:Lactones; D010936:Plant Extracts; C000604054:folenolide; C000604053:folicitin
keywords: Guttiferae; Hypericum oblongifolium; antioxidant; flavone; folenolide; folicitin