title: A 22 years survival and prognostic factors analysis in a homogeneous series of 64 patients with advanced cancer of the tongue and the floor of the mouth.
abstract: OBJECTIVE
  The aim of this study is to evaluate patients with advanced tongue and floor of the mouth carcinoma evaluating clinical and histopathologic parameters as prognostic factors for survival.
  
  
  METHODS
  We studied retrospectively 64 patients with squamous cell carcinomas of the tongue and floor of the mouth in stage III and IV, treated by surgery at first and followed them for at least 22 years or until death, with a median follow-up of 67 months (range, 3-290 months). The prognosis factors evaluation included tumor, patient and treatment related factors using univariate and multivariate statistical analysis.
  
  
  RESULTS
  The overall 5-year and 22-year survival rates were 34.4% and 6.3%, respectively; and the specific 5-year and 22 years survival rates 35.9%. Eleven patients (17.2%) had died of a second primary tumor and 8 (12.5%) of intercurrent diseases. Multivariable Cox regression analysis showed node capsular invasion, number of metastatic nodes and malignancy grading as the main factors associated with survival (p < 0.001).
  
  
  CONCLUSIONS
  A very long-term follow-up allowed for the observation of the specific and the overall survival, influenced by age and comorbidities. The prognosis was strongly influenced by the ganglionar status and the histopathological characteristics of the primary tumor.
authors.affiliation: Department of Maxillofacial Surgery (Head: Jose L. López-Cedrún, MD, DDS, PhD), University Hospital A Coruña, La Coruña, Spain. Electronic address: lopezcedrun@centromaxilofacial.com.
authors.forename: Jose L
authors.initials: JL
authors.lastname: López-Cedrún
authors.affiliation: Department of Health Research and Statistics, University Hospital Río Carrión, Palencia, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Andrés de Llano
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000556:secondary / Q000601:surgery*; D002423:Cause of Death; D015897:Comorbidity; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology*; D009062:Mouth Neoplasms / Q000601:surgery*; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016879:Salvage Therapy; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000601:surgery*
keywords: Floor of the mouth cancer; Oral tongue cancer; Prognostic factors; Radiation therapy; Squamous cell carcinoma; Survival outcome