title: New approaches for imaging and therapy of solid cancer.
abstract: Radionuclide therapy is a systemic treatment that aims to deliver cytotoxic radiation to cancer cells. Due to their properties, antibodies have been considered as suitable agent for the delivery of therapeutic radioisotopes, radioimmunotherapy (RIT). This article gives an overview of new approaches for imaging and therapy of solid cancer with particular attention to strategies to enhance treatment success. Examples of increased antibody uptake by targeting stromal constituent of tumor microenvironment such as fibronectin (FN) an important tumor-associated angiogenesis targeting agent, with specifically designed antibody format will be provided. Strategies oriented to identify patients most likely to benefit from RIT including identification of radiosensitivity profiles, in vivo target identification by teragnostic approach and better prediction of dosimetric estimates would be presents. Combination regimens such as with chemo-radiotherapy and immunotherapy would be also discussed as an approach to enhance RIT success.
authors.affiliation: Nuclear Medicine Unit, Department of Oncology and Advanced Technology, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy - paola.erba@unipi.it.
authors.forename: M
authors.initials: M
authors.lastname: Sollini
authors.forename: R
authors.initials: R
authors.lastname: Boni
authors.forename: A C
authors.initials: AC
authors.lastname: Traino
authors.forename: E
authors.initials: E
authors.lastname: Lazzeri
authors.forename: F
authors.initials: F
authors.lastname: Pasqualetti
authors.forename: L
authors.initials: L
authors.lastname: Modeo
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Petrini
authors.forename: P A
authors.initials: PA
authors.lastname: Erba
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals