title: Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage.
abstract: A new kind of visible-light photocleavable molecule, 4-α-amino acid substituted naphthalimide, is reported. The cleavage occurred at the C-N bond between the 4-amino and the amino acid residue and released a 4-aminonaphthalimide. A lysine substituted naphthalimide exhibited a strong DNA photocleavage activity when irradiated with a blue light LED.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China. sgdh@iccas.ac.cn.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Canliang
authors.initials: C
authors.lastname: Fang
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Liu
authors.forename: Fuyi
authors.initials: F
authors.lastname: Wang
authors.forename: Dihua
authors.initials: D
authors.lastname: Shangguan
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage; D008027:Light; D053644:Naphthalimides / Q000737:chemistry*; D055668:Photochemical Processes
chemical_list: D000596:Amino Acids; D053644:Naphthalimides; D004247:DNA