title: Assessing the early changes of cerebral glucose metabolism via dynamic (18)FDG-PET/CT during cardiac arrest.
abstract: To study the changes of cerebral glucose metabolism (CGM) during the phase of return of spontaneous circulation (ROSC) after cardiac arrest (CA), we used 18-fluorodeoxyglucose-positron emission tomography/computed tomography ((18)FDG-PET/CT) to measure the CGM changes in six beagle canine models. After the baseline (18)FDG-PET/CT was recorded, ventricular fibrillation (VF) was induced for 6 min, followed by close-chest cardiopulmonary resuscitation (CPR) in conjunction with intravenous (IV) administration of epinephrine and external defibrillator shocks until ROSC was achieved, within 30 min. The (18)FDG was recorded prior to intravenous administration at 0 h (baseline), and at 4, 24, and 48 h after CA with ROSC. We evaluated the expression of two key control factors in canine CGM, hexokinase I (HXK I) and HXK II, by immunohistochemistry at the four above mentioned time points. Electrically induced VF of 6 min duration was successfully induced in the dogs. Resuscitation was then performed to maintain blood pressure stability. Serial (18)FDG-PET/CT scans found that the CGM decreased at 4 h after ROSC and remained lower than the baseline even at 48 h. The expression of HXK I and II levels were consistent with the changes in CGM. These data from our present work showed that (18)FDG-PET/CT imaging can be used to detect decreased CGM during CA and was consistent with the results of CMRgl. Furthermore, there were also concomitant changes in the expression of HXK I and HXK II. The decrease in CGM may be an early sign of hyperacute global cerebral ischemia.
authors.affiliation: Emergency Department of Guangzhou First People's Hospital, Guangzhou Medical University, Panfu Road 1, Guangzhou, People's Republic of China.
authors.forename: Ying-Qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Xiao-Xing
authors.initials: XX
authors.lastname: Liao
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Lu
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Dai
authors.forename: Xiang-Song
authors.initials: XS
authors.lastname: Zhang
authors.forename: Xin-Chong
authors.initials: XC
authors.lastname: Shi
authors.forename: Xin
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004285:Dogs; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006323:Heart Arrest / Q000150:complications / Q000378:metabolism*; D008297:Male; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose