title: Formation of DNA-copolymer fibrils through an amyloid-like nucleation polymerization mechanism.
abstract: Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest Ansermet 30, 1211, Geneva 4, Switzerland.
authors.forename: Dawid
authors.initials: D
authors.lastname: Kedracki
authors.forename: Sergey K
authors.initials: SK
authors.lastname: Filippov
authors.forename: Nidhi
authors.initials: N
authors.lastname: Gour
authors.forename: Helmut
authors.initials: H
authors.lastname: Schlaad
authors.forename: Corinne
authors.initials: C
authors.lastname: Nardin
mesh_terms: D000682:Amyloid / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D018736:DNA Adducts / Q000138:chemical synthesis* / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D058726:Nanoconjugates / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000682:Amyloid; D018736:DNA Adducts; D058726:Nanoconjugates; D010080:Oxazoles; D011108:Polymers; C577913:poly(2-oxazoline); D004247:DNA
keywords: DNA copolymers; fibers; hydrogen bonding; nucleation polymerization; self-assembly