title: Clinical Profile of Children with Malformations of Cortical Development.
abstract: OBJECTIVE
  To elucidate the clinical-radiological profile of children with malformations of cortical development.
  
  
  METHODS
  This observational study was conducted at a tertiary care child hospital of north India. Clinical-radiological data records were reviewed and assessment of children's functioning in five key areas of physical, adaptive behavior, social emotional, cognitive and communication was performed using Developmental Profile-3.
  
  
  RESULTS
  Sixty-four cases of "Malformations of cortical development" were studied. The commonest malformations were lissencephaly (14/64), agyria-pachygyria (14/64) and schizencephaly (14/64). Focal cortical dysplasia (n = 12), hemimegalencephaly (n = 4), polymicrogyria (n = 3) and heterotopias (n = 3) were the other malformations seen. On Developmental Profile-3, 90 % children had developmental delay.
  
  
  CONCLUSIONS
  The present study provides important data on the pattern of malformations of cortical development seen in a tertiary care hospital. It emphasizes that all children with developmental delay and seizures should be evaluated with magnetic resonance imaging.
authors.affiliation: Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Gupta
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Sahu
authors.forename: Anju
authors.initials: A
authors.lastname: Gupta
authors.forename: Prabhjot
authors.initials: P
authors.lastname: Malhi
authors.forename: N
authors.initials: N
authors.lastname: Khandelwal
authors.forename: Pratibha
authors.initials: P
authors.lastname: Singhi
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D054220:Malformations of Cortical Development / Q000175:diagnosis*; D012189:Retrospective Studies; D062606:Tertiary Care Centers