title: The economic burden of gastroschisis: costs of a birth defect.
abstract: BACKGROUND
  Intestinal dysfunction and feeding intolerance are comorbidities associated with the abdominal wall birth defect of gastroschisis (GS). These factors contribute to prolonged hospitalization in this population of patients. The purpose of this study was to evaluate the economic burden on a state and national level.
  
  
  METHODS
  From 2007-2011, the Healthcare Cost and Utilization Project database was queried for the following national and state of Texas data: number of discharges, length of stay (LOS), costs, and charges for all pediatric hospital stays ± CPT code 54.71 denoting GS repair for infants aged <1 y. The effect of GS on LOS, cost, and charges was calculated by the weighted average of the differences and is represented by the combined estimated difference (CED).
  
  
  RESULTS
  Infants <1 y represent 74% of all pediatric discharges nationally and only 0.04% of these discharges are accounted for by GS patients. Nationally, GS patients had significantly longer LOS (CED 38.5 ± 0.9 d, P < 0.0001); increased costs (CED $79,733 ± $2119, P < 0.0001); and charges (CED $249,999 ± $9562, P < 0.0001). The Texas state data mirrored our findings for the national data. There was no significant difference in the LOS, costs, and charges between the national and state level.
  
  
  CONCLUSIONS
  Our study shows that GS patients represent an extremely small minority of national and Texas pediatric discharges; however, these patients LOS and costs greatly exceed non-GS patients. Further investigation into factors influencing the development of intestinal dysfunction in these patients is needed to significantly impact the economic burden of the abdominal wall birth defect of GS.
authors.affiliation: Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas. Electronic address: Diana.M.Hook@uth.tmc.edu.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Hook-Dufresne
authors.affiliation: Gastroenterology Section, Department of Medicine, Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Yu
authors.affiliation: Department of Pedatrics, Gastroenterology Division, University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Vinay
authors.initials: V
authors.lastname: Bandla
authors.affiliation: Department of Pedatrics, Gastroenterology Division, University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Essam
authors.initials: E
authors.lastname: Imseis
authors.affiliation: Department of Pediatric Surgery, University of Texas Medical School at Houston, Houston, Texas.
authors.forename: Stacey D
authors.initials: SD
authors.lastname: Moore-Olufemi
mesh_terms: D020139:Gastroschisis / Q000191:economics*; D017048:Health Care Costs; D017722:Hospital Charges / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D013781:Texas
keywords: Costs; Gastroschisis; Intestinal failure