title: A comparison of the effects of morphine and sublingual desmopressin combination therapy with morphine alone in treatment of renal colic: a controlled clinical trial.
abstract: OBJECTIVE
  To compare the therapeutic efficacy of combined desmopressin and morphine with morphine and placebo on acute renal colic.
  
  
  METHODS
  In a single blind case-control clinical trial 81 consecutive patients, 54 males and 27 females with the mean age of 30.12 ± 9.88 years, presenting with acute renal colic to the urology emergency unit were studied. The patients were randomly assigned into two groups. The 40 cases were treated with 0.1 mg/kg IM morphine and 60 μg of sublingual desmopressin melt; whereas the 41 controls received the same dose of morphine beside a placebo.
  
  
  RESULTS
  There were no significant statistical differences regarding the mean age, gender, stone size, location and affected side between the two groups. Our results showed a significantly higher acuity of pain in the study group in comparison to the controls at 10, 20 and 30 minutes of receiving the medication (P = .06, .017 and P = .008, respectively).
  
  
  CONCLUSIONS
  No superiority was found in adding desmopressin to morphine compared to the traditional treatments (opioids only) in relieving the pain of acute renal colic cases.
authors.affiliation: Department of Urology, Mashhad University of Medical Sciences, Mashhad, Iran.. Keshvarim@mums.ac.ir.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Keshvari Shirvani
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Darabi Mahboub
authors.forename: Mahdi
authors.initials: M
authors.lastname: Ghazi
authors.forename: Alireza
authors.initials: A
authors.lastname: Delijani
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009020:Morphine / Q000627:therapeutic use*; D010147:Pain Measurement; D056844:Renal Colic / Q000188:drug therapy* / Q000209:etiology; D016037:Single-Blind Method; D014545:Urinary Calculi / Q000150:complications; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D006490:Hemostatics; D009020:Morphine; D003894:Deamino Arginine Vasopressin