title: Sustained delivery of retinoids to prevent photoreceptor death.
abstract: Delivery of hydrophobic compounds to photoreceptors within the retina presents unique challenges due to the anatomy and physiology of the eye. Derivatives of vitamin A (retinoids) are essential to the function and survival of photoreceptors and in the absence of an intrinsic mechanism to metabolize these compounds (visual cycle) leads to extensive loss of photoreceptors and visual function. In this chapter, we describe a method for the sustained delivery of retinoids to young mice that lack a functioning visual cycle to promote survival of photoreceptors.
authors.affiliation: Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, MN, 55455, USA.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Tang
authors.forename: Rosalie K
authors.initials: RK
authors.lastname: Crouch
mesh_terms: D000818:Animals; D051379:Mice; D010786:Photoreceptor Cells / Q000166:cytology / Q000187:drug effects; D012160:Retina / Q000378:metabolism; D017949:Retinal Cone Photoreceptor Cells / Q000187:drug effects*; D012176:Retinoids / Q000008:administration & dosage* / Q000494:pharmacology; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology; D019745:cis-trans-Isomerases / Q000235:genetics / Q000378:metabolism; D000099178:Retinoid Isomerohydrolase
chemical_list: D012176:Retinoids; D014801:Vitamin A; D019745:cis-trans-Isomerases; D000099178:Retinoid Isomerohydrolase