title: Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients.
abstract: OBJECTIVE
  To evaluate fetuin-A level and carotid intima-media thickness (CIMT) in adolescent type 1 diabetics.
  
  
  METHODS
  The study included 62 type 1 diabetic patients and 30 healthy volunteers of the same age and sex. Blood sample was taken for assessment of glycosylated hemoglobin (HbA1), lipid profile, and fetuin-A. Urine sample was also taken for assessment of albumin/creatinine ratio. Anthropometric measurements were taken, including weight, height, and waist and hip circumference. CIMT was assessed for all patients and controls.
  
  
  RESULTS
  Serum fetuin-A, Rt., Lt. and both CIMT were significantly higher in diabetics. Fetuin-A had a significant positive correlation with duration of disease, waist and hip circumference, BMI, BMI SDS, waist/height ratio, Rt., Lt. and both CIMT. Stepwise multiple regression analysis revealed that the duration of disease, waist/height ratio, and HDL-c were the factors related to fetuin-A.
  
  
  CONCLUSIONS
  Adolescent type 1 diabetic patients have high fetuin-A levels and increased CIMT, with the latter representing the development of early atherosclerosis. In this light, adolescents with type 1 diabetes require frequent follow up for early detection of atherosclerosis.
authors.forename: Soha M
authors.initials: SM
authors.lastname: Abd El Dayem
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Battah
authors.forename: Abo El Magd
authors.initials: Ael M
authors.lastname: El Bohy
authors.forename: Amal
authors.initials: A
authors.lastname: El Shehaby
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis / Q000378:metabolism*
chemical_list: D060749:alpha-2-HS-Glycoprotein