title: The BAFFling function of Syk in B-cell homeostasis.
abstract: The TNF receptor family member BAFFR is essential for providing mature B cells with pro-survival signals and has recently been claimed to transduce these, though not exclusively, via a Syk-dependent signaling hub that feeds into ERK/AKT activation. In this issue of The EMBO Journal, Hobeika et al (2015) describe a synergistic prosurvival scenario involving BAFFR and CD19, which remains functional under Syk null conditions and is able to maintain mature B-cell survival. The authors hence propose a BAFFR-/CD19-driven mechanism to act in parallel with homeostatic NF-κB/AKT activation in non-stimulated B cells.
authors.affiliation: Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Königsberger
authors.affiliation: Mammalian Cell Signaling Laboratory, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
authors.forename: Friedemann
authors.identifier: http://orcid.org/0000-0002-3002-8237
authors.initials: F
authors.lastname: Kiefer
mesh_terms: D000818:Animals; D018941:Antigens, CD19 / Q000276:immunology*; D053265:B-Cell Activation Factor Receptor / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D000072377:Syk Kinase
chemical_list: D018941:Antigens, CD19; D053265:B-Cell Activation Factor Receptor; D047908:Intracellular Signaling Peptides and Proteins; C486662:Tnfrsf13c protein, mouse; D011505:Protein-Tyrosine Kinases; D000072377:Syk Kinase; C000606897:Syk protein, mouse