title: [Focal therapy for prostate cancer: German version].
abstract: Focal therapy is a treatment strategy for men with localized prostate cancer that may serve as an alternative option to radical therapy. A number of minimally invasive ablative technologies are available to deliver treatment, and the energies most commonly used include high-intensity focused ultrasound and cryotherapy. The benefit of a tissue-preserving approach is the limitation of damage to key structures such as the neurovascular bundles, external urinary sphincter, rectal mucosa and bladder neck. This in turn minimizes side effects typically associated with radical therapies whilst also aiming to maintain oncological control. Over 30 single-centre studies of focal therapy have been published to date reporting excellent continence rates, good potency rates and acceptable short-term oncological outcomes. However, there are a number of controversial aspects associated with focal therapy including the index lesion hypothesis, patient selection criteria, assessment of treatment effect and the lack of medium- and long-term oncological outcomes. In the process of the adoption of new technology, there is a limited window of opportunity to provide this evidence in well-designed prospective trials. Men should be allowed to benefit from the potential advantages of this novel treatment whilst under close surveillance. An English version of this article is available under dx.doi.org/10.1007/s00120-014-3734-7.
authors.affiliation: Division of Surgery and Interventional Sciences, University College London, 4th Floor, Room 4.23, 132 Hampstead Road, NW1 2PS, London, UK, veeru.kasi@ucl.ac.uk.
authors.forename: V
authors.initials: V
authors.lastname: Kasivisvanathan
authors.forename: T T
authors.initials: TT
authors.lastname: Shah
authors.forename: I
authors.initials: I
authors.lastname: Donaldson
authors.forename: A
authors.initials: A
authors.lastname: Kanthabalan
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: M
authors.initials: M
authors.lastname: Emberton
authors.forename: H U
authors.initials: HU
authors.lastname: Ahmed
mesh_terms: D003452:Cryosurgery / Q000379:methods*; D019317:Evidence-Based Medicine; D005858:Germany; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D059351:Organ Sparing Treatments / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000601:surgery*; D016896:Treatment Outcome