title: Induction Hedgehog pathway inhibition followed by combined-modality radiotherapy for basal cell carcinoma.
abstract: Basal cell carcinoma (BCC), the most common cancer in the U.S.A., is treated primarily with local excision. In some cases, lesion size, location or extent prevent complete resection. Locally advanced BCC responds to systemic therapy with the Hedgehog pathway inhibitor vismodegib, but withdrawal of treatment may result in disease relapse. Here we present a case of locally advanced auricular BCC treated with induction vismodegib and radiation, resulting in durable local control and an acceptable level of acute toxicity.
authors.affiliation: Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, U.S.A.
authors.forename: D R
authors.initials: DR
authors.lastname: Raleigh
authors.affiliation: Department of Medicine, University of California San Francisco, San Francisco, CA, U.S.A.
authors.forename: A
authors.initials: A
authors.lastname: Algazi
authors.affiliation: Department of Dermatology, University of California San Francisco, San Francisco, CA, U.S.A.
authors.forename: S T
authors.initials: ST
authors.lastname: Arron
authors.affiliation: Department of Dermatology, University of California San Francisco, San Francisco, CA, U.S.A.
authors.forename: I M
authors.initials: IM
authors.lastname: Neuhaus
authors.affiliation: Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, U.S.A.
authors.forename: S S
authors.initials: SS
authors.lastname: Yom
mesh_terms: D000813:Anilides / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004428:Ear Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*
chemical_list: D000813:Anilides; D000970:Antineoplastic Agents; D053823:Hedgehog Proteins; C538724:HhAntag691; D011725:Pyridines