title: In-situ formation of growth-factor-loaded coacervate microparticle-embedded hydrogels for directing encapsulated stem cell fate.
abstract: The spontaneous formation of coacervate microdroplet-laden photo-crosslinked hydrogels derived from the simple mixing of oxidized, methacrylated alginate (OMA) and methacrylated gelatin (GelMA) enables simultaneous creation of drug-laden microdroplets and encapsulation of stem cells in photopolymerized coacervate hydrogels under physiological conditions. This can be utilized as a novel platform for in situ formation of localized, sustained bioactive molecule delivery to encapsulate stem cells for therapeutic applications.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA.
authors.forename: Oju
authors.initials: O
authors.lastname: Jeon
authors.forename: David W
authors.initials: DW
authors.lastname: Wolfson
authors.forename: Eben
authors.initials: E
authors.lastname: Alsberg
mesh_terms: D002214:Capsules; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology*; D008863:Microspheres; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects*; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D002214:Capsules; D020100:Hydrogels
keywords: alginate; coacervate; gelatin; microdroplet; microencapsulation