title: Promoting apoptosis of neutrophils and phagocytosis by macrophages: novel strategies in the resolution of inflammation.
abstract: Acute inflammation is the body's response to infection or injury, characterised by the rapid infiltration of polymorphonuclear neutrophils to the site of injury followed by monocytes, which differentiate locally into macrophages. The latter are essential for the removal of effete neutrophils and provided that the harmful agent is eliminated, removal of neutrophils will lead to the resolution of inflammation. Perturbations in this process result in the persistence of inflammation and close control of pathways associated with resolution are necessary to avoid chronic inflammation, autoimmunity, or both. As our understanding of these processes increase, drugs able to trigger pro-resolution pathways may represent an effective strategy for treating chronic inflammatory diseases.
authors.affiliation: INSERM U1016, Cochin Institute Paris, France; Paris Descartes University, Paris, France; CNRS-UMR 8104, Paris, France; Centre of Excellence, LABEX Inflamex, University Paris Diderot, France.
authors.forename: Katherine R
authors.initials: KR
authors.lastname: Martin
authors.affiliation: INSERM U1016, Cochin Institute Paris, France; Paris Descartes University, Paris, France; CNRS-UMR 8104, Paris, France; Centre of Excellence, LABEX Inflamex, University Paris Diderot, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Ohayon
authors.affiliation: INSERM U1016, Cochin Institute Paris, France; Paris Descartes University, Paris, France; CNRS-UMR 8104, Paris, France; Centre of Excellence, LABEX Inflamex, University Paris Diderot, France.
authors.forename: Veronique
authors.initials: V
authors.lastname: Witko-Sarsat
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001327:Autoimmune Diseases / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D008264:Macrophages / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D018809:Proliferating Cell Nuclear Antigen
chemical_list: D018809:Proliferating Cell Nuclear Antigen