title: Hyperactivity in the medial olivocochlear efferent system is a common feature of tinnitus and hyperacusis in humans.
abstract: Tinnitus and hyperacusis are common, burdensome sources of morbidity with a high rate of co-occurrence. Knudson et al. (J Neurophysiol 112: 3197-3208, 2014) demonstrated that efferent suppression of cochlear activity by the medial olivocochlear system is enhanced in individuals with tinnitus and/or hyperacusis. Their findings stress that atypical activity in the efferent auditory pathway may represent a shared substrate, as well as a potential therapeutic target, in tinnitus and hyperacusis.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania jjs149@pitt.edu.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Sturm
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and.
authors.forename: Catherine J C
authors.initials: CJ
authors.lastname: Weisz
mesh_terms: D001306:Auditory Pathways; D003051:Cochlea; D004525:Efferent Pathways; D006801:Humans; D012001:Hyperacusis; D014012:Tinnitus
keywords: efferent; hyperacusis; medial olivocochlear; tinnitus