title: Efficacy and Tolerability of Steroid-Free, Over-the-Counter Treatment Formulations in Infants and Children With Atopic Dermatitis.
abstract: BACKGROUND
  Two steroid-free, over-the-counter skin protectant products have been developed for the care and treatment of atopic dermatitis (AD)-Eucerin Eczema Relief Body Crème (Body Cream) for daily skin moisturization and Eucerin Eczema Relief Instant Therapy cream (Instant Therapy) for treatment of AD flare-ups. We tested the efficacy and tolerability of these formulations in infants and children with AD.
  
  
  METHODS
  Study 1: Body Cream was applied twice daily to the lower legs of 64 children with a history of AD (aged 3 months to 12 years) for 14 days. Study 2: Instant Therapy was applied to active lesions and surrounding skin of 29 children (aged 3 months to 12 years) with active atopic lesions. Assessments were performed at baseline and Days 7 and 14. Symptoms were assessed using the Atopic Dermatitis Severity Index in Study 2.
  
  
  RESULTS
  Body Cream significantly improved skin hydration and reduced itching, burning/stinging, erythema, and tactile roughness. Instant Therapy significantly improved skin hydration and AD symptoms, notably pruritus, erythema, and lichenification. Both products were safe and well tolerated.
  
  
  CONCLUSIONS
  Body Cream and Instant Therapy were effective and well tolerated in the treatment of AD in children. These products provide steroid-free, nonprescription therapy for the maintenance and treatment of acute eczema and were proven effective and safe in infants as young as 3 months.
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Weber
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: James H
authors.initials: JH
authors.lastname: Herndon
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Melissa
authors.initials: M
authors.lastname: Ewer
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Stephens
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Iris
authors.initials: I
authors.lastname: Flick
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Alexander
authors.initials: A
authors.lastname: Filbry
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Gitta
authors.initials: G
authors.lastname: Neufang
authors.affiliation: Teresa M. Weber, PhD, U.S. Research and Development, Beiersdorf, Inc., Wilton, CT.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Schoelermann
keywords: Atopic dermatitis; Children; Eczema; Infants; OTC; Steroid-free; Topical