title: Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.
  
  
  METHODS
  The study population consisted of 972 Caucasian subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 patients with no history of coronary artery disease. Polymorphisms in thioredoxin reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied.
  
  
  RESULTS
  Individuals carrying CC+CT genotypes of rs1548357 TXNRD2 polymorphism had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, OR=0.589, 95% CI=0.368-0.942, P=0.027).
  
  
  CONCLUSIONS
  The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for MI in subjects with T2DM of Slovenian origin.
authors.affiliation: Internal Department, General Hospital Izola, Polje 35, 6310 Izola, Slovenia.
authors.forename: Stojan
authors.initials: S
authors.lastname: Kariž
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, University Ljubljana, Korytkova 2, 1105 Ljubljana, Slovenia.
authors.forename: Sara
authors.initials: S
authors.lastname: Mankoč
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, University Ljubljana, Korytkova 2, 1105 Ljubljana, Slovenia. Electronic address: daniel.petrovic@mf.uni-lj.si.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovič
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017524:Slovenia / Q000453:epidemiology; D054482:Thioredoxin Reductase 2 / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C516127:TXNRD2 protein, human; D054482:Thioredoxin Reductase 2
keywords: Genetic polymorphisms; Myocardial infarction; Oxidative stress; Thioredoxin reductase 2; Type 2 diabetes mellitus