title: Correlation of 15-prostagladin dehydrogenase expression with clinicopathological factors and survival rate in gastric adenocarcinoma.
abstract: BACKGROUND
  The prostaglandin (PG) E2 level, which is associated with oncogenesis, progression and metastasis in various types of cancer, is determined by reciprocal regulation of 15-prostaglandin dehydrogenase (15-PGDH) and cyclooxygenase-2. This study investigated 15-PGDH expression in gastric adenocarcinoma, the associations between 15-PGDH expression and clinicopathological factors, and the correlation between 15-PGDH expression and the 5-year gastric-cancer-specific survival rate (5-year GCSS).
  
  
  METHODS
  From 175 patients who underwent gastrectomy, we obtained biopsies of gastric adenocarcinoma tissues and adjacent normal tissues for preparation as formalin-fixed, paraffin-embedded specimens and conducted an immunohistochemical analysis.
  
  
  RESULTS
  15-PGDH expression was low in 65.1% of cases. 15-PGDH expression showed no relationship with age or gender, but was significantly correlated with the pathologic type, T stage, N stage, TNM stage, positive lymph node metastasis, metastasis to a larger quantity of lymph nodes, positive lymphatic invasion, positive vascular invasion, positive perineural invasion, and palliative gastrectomy. The 5-year GCSS of the low-expression group was 77.19% and a lower level of 15-PGDH expression correlated to a lower 5-year GCSS. 15-PGDH expression significantly influenced the 5-year GCSS on univariate but not multivariate analysis.
  
  
  CONCLUSIONS
  Our findings indicate that 15-PGDH expression was low in gastric adenocarcinoma and was correlated with the clinicopathological factors associated with prognosis and a more advanced stage of gastric adenocarcinoma. Also, 15-PGDH expression was significantly associated with the 5-year GCSS, but was not an independent prognostic factor thereof.
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Sang Hyuk
authors.initials: SH
authors.lastname: Seo
authors.affiliation: Department of Pathology, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Mi Seon
authors.initials: MS
authors.lastname: Kang
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea. Electronic address: inwoodog@naver.com.
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Min Sung
authors.initials: MS
authors.lastname: An
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Tae Kwun
authors.initials: TK
authors.lastname: Ha
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Ki Beom
authors.initials: KB
authors.lastname: Bae
authors.affiliation: Department of Pharmacology and Clinical Trial Center, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Oh
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Choi
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Oh
authors.affiliation: Department of Surgery, Busan Paik Hospital, Inje University, Republic of Korea.
authors.forename: Young Kil
authors.initials: YK
authors.lastname: Choi
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005743:Gastrectomy; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000032:analysis*; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality* / Q000473:pathology*; D015996:Survival Rate
chemical_list: D006911:Hydroxyprostaglandin Dehydrogenases; C035859:15-hydroxyprostaglandin dehydrogenase
keywords: 15-Prostaglandin dehydrogenase; 5 Year gastric cancer specific survival rate; Human gastric adenocarcinoma