title: [Insulin-like growth factor 1-induced changes in hemoporphyrin conformation in hemoglobin and NO-transporting function in human erythrocytes].
abstract: The evidence on the effect of different insulin-like growth factor concentrations on a state of human erythrocytes is provided. Activation of the insulin-like growth factor receptors led to changes in the conformation of hemoglobin, NO-transporting function in erythrocytes and also in micro-viscosity of the cell membrane. It was shown for the first time that at the binding of the insulin-like growth factor to a cell surface, hemoglobin of erythrocytes alters its conformations and affinity to ligands.
authors.forename: S S
authors.initials: SS
authors.lastname: Kovalenko
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Parshina
authors.forename: A I
authors.initials: AI
authors.lastname: Iusipovich
authors.forename: G V
authors.initials: GV
authors.lastname: Maksimov
authors.forename: A B
authors.initials: AB
authors.lastname: Rubin
mesh_terms: D004910:Erythrocyte Membrane / Q000737:chemistry*; D005260:Female; D006418:Heme / Q000737:chemistry*; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000737:chemistry*; D008297:Male; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D006454:Hemoglobins; C583557:IGF1 protein, human; D009569:Nitric Oxide; D006418:Heme; D007334:Insulin-Like Growth Factor I