title: Identification and utilization of donor and recipient genetic variants to predict survival after HCT: are we ready for primetime?
abstract: Overall survival following hematopoietic cell transplantation (HCT) has improved over the past two decades through better patient selection and advances in HLA typing, supportive care, and infection prophylaxis. Nonetheless, mortality rates are still unsatisfactory and transplant-related mortality remains a major cause of death after unrelated allogeneic HCT. Since there are no known pre-HCT, non-HLA biologic predictors of survival following transplant, for over a decade, scientists have been investigating the role of non-HLA germline genetic variation in survival and treatment-related mortality after HCT. Variation in single nucleotide polymorphisms (SNPs) has the potential to impact chemotherapy, radiation, and immune responses, leading to different post-HCT survival outcomes. In this paper, we address the current knowledge of the contribution of genetic variation to survival following HCT and discuss study design and methodology for investigating HCT survival on a genomic scale.
authors.affiliation: Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA, Lara.Sucheston@roswellpark.org.
authors.forename: Lara E
authors.initials: LE
authors.lastname: Sucheston-Campbell
authors.forename: Alyssa
authors.initials: A
authors.lastname: Clay
authors.forename: Philip L
authors.initials: PL
authors.lastname: McCarthy
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhu
authors.forename: Leah
authors.initials: L
authors.lastname: Preus
authors.forename: Marcelo
authors.initials: M
authors.lastname: Pasquini
authors.forename: Kenan
authors.initials: K
authors.lastname: Onel
authors.forename: Theresa
authors.initials: T
authors.lastname: Hahn
mesh_terms: D014644:Genetic Variation; D006086:Graft vs Host Disease / Q000517:prevention & control; D006680:HLA Antigens; D019337:Hematologic Neoplasms / Q000235:genetics / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D054340:Receptors, KIR / Q000235:genetics; D015996:Survival Rate; D014019:Tissue Donors; D066027:Transplant Recipients; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens; D054340:Receptors, KIR