title: Individuals with hematological malignancies before undergoing chemotherapy present oxidative stress parameters and acute phase proteins correlated with nutritional status.
abstract: Hematological malignancies present abnormal blood cells that may have altered functions. This study aimed to evaluate nutritional status, acute phase proteins, parameters of cell's functionality, and oxidative stress of patients with hematological malignancies, providing a representation of these variables at diagnosis, comparisons between leukemias and lymphomas and establishing correlations. Nutritional status, C-reactive protein (CRP), albumin, phagocytic capacity and superoxide anion production of mononuclear cells, lipid peroxidation and catalase activity in plasma were evaluated in 16 untreated subjects. Main diagnosis was acute leukemia (n = 9) and median body mass index (BMI) indicated overweight (25.6 kg/m(2)). Median albumin was below (3.2 g/dL) and CRP above (37.45 mg/L) the reference values. Albumin was inversely correlated with BMI (r = -0.53). Most patients were overweight before the beginning of treatment and had a high CRP/albumin ratio, which may indicate a nutrition inflammatory risk. BMI values correlated positively with lipid peroxidation and catalase activity. A strong correlation between catalase activity and lipid peroxidation was found (r = 0.75). Besides the elevated BMI, these patients also have elevated CRP values and unexpected relations between nutritional status and albumin, reinforcing the need for nutritional counseling during the course of chemotherapy, especially considering the correlations between oxidative stress parameters and nutritional status evidenced here.
authors.affiliation: a Postgraduate Program in Nutrition , Federal University of Santa Catarina , Florianópolis , Brazil.
authors.forename: Carolina de Quadros
authors.initials: Cde Q
authors.lastname: Camargo
authors.forename: Dayanne da Silva
authors.initials: Dda S
authors.lastname: Borges
authors.forename: Paula Fernanda
authors.initials: PF
authors.lastname: de Oliveira
authors.forename: Thayz Rodrigues
authors.initials: TR
authors.lastname: Chagas
authors.forename: Joanita Angela Gonzaga
authors.initials: JA
authors.lastname: Del Moral
authors.forename: Giovanna Steffanello
authors.initials: GS
authors.lastname: Durigon
authors.forename: Bruno Vieira
authors.initials: BV
authors.lastname: Dias
authors.forename: André Guedes
authors.initials: AG
authors.lastname: Vieira
authors.forename: Patrick
authors.initials: P
authors.lastname: Gaspareto
authors.forename: Erasmo Benício Santos de Moraes
authors.initials: EB
authors.lastname: Trindade
authors.forename: Everson Araújo
authors.initials: EA
authors.lastname: Nunes
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress; D012709:Serum Albumin / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D012709:Serum Albumin; D002097:C-Reactive Protein