title: Associations of serum adipocyte fatty acid binding protein with body composition and fat distribution in nondiabetic Chinese women.
abstract: BACKGROUND
  Previous studies have demonstrated evidence of a positive relationship between serum adipocyte fatty acid binding protein (A-FABP) and obesity. However, associations of A-FABP with body composition and ectopic fat accumulation remain unclear.
  
  
  OBJECTIVE
  This study aimed to elucidate the effect of body composition, visceral fat area (VFA), and subcutaneous fat area (SFA) on serum A-FABP levels in a cohort of Chinese women without diabetes mellitus.
  
  
  METHODS
  A total of 2108 women without diabetes (760 premenopausal and 1348 postmenopausal women; age, 20-78 y) selected from the Shanghai Obesity Study were enrolled.
  
  
  METHODS
  VFA and SFA were measured by magnetic resonance imaging, and body composition was determined by bioelectrical impedance analysis. A high VFA was defined as ≥ 80 cm(2). A high SFA was defined as that above the 75th percentile cutoff point of the menopause-specific population, respectively.
  
  
  RESULTS
  Serum A-FABP levels were higher in postmenopausal than premenopausal women (P < .001). Both premenopausal and postmenopausal women with an isolated high VFA had higher A-FABP levels than did those with an isolated high SFA (P = .017 and .002, respectively). In both body mass index (BMI) groups (< 25 and ≥ 25 kg/m(2)), women with a high VFA had higher serum A-FABP levels regardless of their menopausal status. Multiple stepwise regression analysis showed that A-FABP was independently associated with fat mass (Standardized β = 0.417 and 0.252 for premenopausal and postmenopausal status, respectively, both P < .001). Moreover, VFA was identified as an independent risk factor for A-FABP in postmenopausal women (Standardized β = 0.114, P = .001). Application of the same regression analyses model to the two BMI groups produced similar results in both BMI categories.
  
  
  CONCLUSIONS
  Serum A-FABP levels were associated with fat mass, and were also influenced by VFA after menopause in Chinese women without diabetes mellitus.
authors.affiliation: Department of Endocrinology and Metabolism (Y.H., X.M., Y.L., X.H., X.P., Y.B., W.J.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China; and Department of Radiology (Y.X.), Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Hao
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.forename: Xiang
authors.initials: X
authors.lastname: Hu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Pan
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001823:Body Composition / Q000502:physiology*; D050218:Body Fat Distribution; D002681:China; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000502:physiology*; D008875:Middle Aged; D055815:Young Adult
chemical_list: C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins