title: Effects of aging and gender on striatal and extrastriatal [123I]FP-CIT binding in Parkinson's disease.
abstract: To investigate the effects of aging and gender on brain dopamine and serotonin transporter bindings, we analyzed [(123)I]FP-CIT single-photon emission computed tomography scans of 231 Parkinson's disease (PD) patients and 230 controls. An automated region-of-interest-based method (BRASS automated analysis software) was used for striatal regions and a voxel-based method (Statistical Parametric Mapping software, SPM8) for the entire brain. In controls, aging was associated with a decline of 3.6%-4.6% per decade in striatal binding. Multiple extrastriatal regions also showed age-related declines. In PD patients, age-related declines were only observed in the caudate nuclei, thalamus, olfactory, and cingulate cortices with a comparable rate of decline as that in controls. Female subjects had higher caudate nucleus binding compared with males with a similar near-significant difference in the right putamen. The results demonstrate that the aging effect is limited in PD, which is possibly because of disease-related excess variation, and the results do not support the theory of accelerated aging of the dopaminergic system in PD. Women have higher caudate nucleus dopamine transporter binding compared with men in both normal and degenerated dopamine systems.
authors.affiliation: Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland. Electronic address: valtteri.kaasinen@tyks.fi.
authors.forename: Valtteri
authors.initials: V
authors.lastname: Kaasinen
authors.affiliation: Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland; Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Neurophysiology, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Juho
authors.initials: J
authors.lastname: Joutsa
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Tommi
authors.initials: T
authors.lastname: Noponen
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Jarkko
authors.initials: J
authors.lastname: Johansson
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Marko
authors.initials: M
authors.lastname: Seppänen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D002421:Caudate Nucleus / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D011485:Protein Binding; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism; D012727:Sex Characteristics; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D004298:Dopamine
keywords: Aging; Dopamine; Gender; Parkinson's disease; SPECT