title: The Association of Elevated HDL Levels With Carotid Atherosclerosis in Middle-Aged Women With Untreated Essential Hypertension.
abstract: High-density lipoprotein cholesterol (HDL-C), a negative risk factor, is positively associated with a decreased risk of coronary heart disease. We investigated the association between high HDL-C levels and target organ damage (TOD) in never treated women with hypertension. We measured HDL-C levels in 117 women followed by estimation of TODs, that is, pulse wave velocity, microalbuminuria, left ventricular mass index, coronary flow reserve, and carotid intima-media thickness (cIMT). Women were divided into 2 groups (HDLH and HDLL), regarding HDL-C quartiles (upper quartile vs the first 3 lower quartiles). In HDLH group : HDL ≥70 mg/dL), cIMT was nonindependently, negatively related to HDL-C (ρ = -.42, P < .05). Using receiver -operating characteristic curve (ROC) analysis in the HDLH group, we concluded that the cutoff value of HDL ≥76.5 mg/dL moderately predicted the absence of carotid atherosclerosis (area under the curve: 0.77, P = .02; confidence interval: 0.57-0.97; sensitivity 73% and specificity 67%). Increased HDL-C may predict the absence of carotid atherosclerosis in middle-age women with untreated essential hypertension and consequently contribute to total cardiovascular risk estimation and treatment planning.
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece seliani@hotmail.com.
authors.forename: Helen
authors.initials: H
authors.lastname: Triantafyllidi
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Pavlidis
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Trivilou
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: Ignatios
authors.initials: I
authors.lastname: Ikonomidis
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Tzortzis
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: Iosif
authors.initials: I
authors.lastname: Xenogiannis
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Schoinas
authors.affiliation: Second Department of Cardiology, Medical School, University of Athens, ATTIKON Hospital, Athens, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Lekakis
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002340:Carotid Artery Diseases / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D065840:Protective Factors; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL
keywords: HDL; atheromatosis; carotid intima–media thickness; hypertension; target organ damage