title: [Do natriuretic peptides have a new chance in treatment of heart failure?].
abstract: The effect of natriuretic peptides on cardiovascular and renal system offers a potential benefit in therapy of hypertension and heart failure; however the current results of clinical trials are not encouraging. Synthetic B natriuretic peptide has demonstrated short-term hemodynamic improvement in patients, but in terms of renal function and long-term prognosis the effect was questionable. Nevertheless, new hope is ularitid a dual inhibitor of neprilysin and ARB: LCZ 696, the ongoing clinical studies and previous data from pilot studies appear promising.
authors.forename: Lenka
authors.initials: L
authors.lastname: Špinarová
authors.forename: Jindřich
authors.initials: J
authors.lastname: Špinar
authors.forename: Jiří
authors.initials: J
authors.lastname: Vítovec
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000627:therapeutic use*; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D020097:Natriuretic Peptide, Brain