title: Correlation of Childhood Obesity and Related Insulin Resistance with Leptin and Retinol Binding Protein 4.
abstract: OBJECTIVE
  To study the correlation of obesity with various metabolic parameters and correlation between insulin resistance and leptin and retinol binding protein 4 (RBP4) levels.
  
  
  METHODS
  This is a cross sectional study in a tertiary care children's hospital wherein 98 obese children were included and their metabolic parameters analysed with regards to insulin resistance and RBP4 levels.
  
  
  RESULTS
  Leptin levels were abnormal for all children and high RBP4 levels were observed in 69.6 %. There was no significant association between insulin resistance and RBP4 levels (p 0.8).
  
  
  CONCLUSIONS
  RBP4, the sole retinol transporter in blood, secreted from adipocytes and liver has been implicated in insulin resistance. The index study however, did not show a significant positive association.
authors.affiliation: Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital and The CHILDS Trust Medical Research Foundation, Chennai, Tamil Nadu, 600034, India, dr_vasanthi@hotmail.com.
authors.forename: Vasanthi
authors.initials: V
authors.lastname: Thiruvengadam
authors.forename: Sumanth
authors.initials: S
authors.lastname: Amperayani
authors.forename: R Prakash
authors.initials: RP
authors.lastname: Babu
authors.forename: Ramya
authors.initials: R
authors.lastname: Uppuluri
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D020738:Leptin / Q000097:blood*; D008297:Male; D063766:Pediatric Obesity / Q000378:metabolism / Q000503:physiopathology*; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*
chemical_list: D020738:Leptin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma