title: Combination therapy in hypertension: an Asia-Pacific consensus viewpoint.
abstract: Hypertension incurs a significant healthcare burden in Asia-Pacific countries, which have suboptimal rates of blood pressure (BP) treatment and control. A consensus meeting of hypertension experts from the Asia-Pacific region convened in Hanoi, Vietnam, in April 2013. The principal objectives were to discuss the growing problem of hypertension in the Asia-Pacific region, and to develop consensus recommendations to promote standards of care across the region. A particular focus was recommendations for combination therapy, since it is known that most patients with hypertension will require two or more antihypertensive drugs to achieve BP control, and also that combinations of drugs with complementary mechanisms of action achieve BP targets more effectively than monotherapy. The expert panel reviewed guidelines for hypertension management from the USA and Europe, as well as individual Asia-Pacific countries, and devised a treatment matrix/guide, in which they propose the preferred combination therapy regimens for patients with hypertension, both with and without compelling indications. This report summarizes key recommendations from the group, including recommended antihypertensive combinations for specific patient populations. These strategies generally entail initiating therapy with free drug combinations, starting with the lowest available dosage, followed by treatment with single-pill combinations once the BP target has been achieved. A single reference for the whole Asia-Pacific region may contribute to increased consistency of treatment and greater proportions of patients achieving BP control, and hence reducing hypertension-related morbidity and mortality.
authors.affiliation: Cyberjaya University College of Medical Sciences , Selangor , Malaysia.
authors.forename: Abdul Rashid
authors.initials: AR
authors.lastname: Abdul Rahman
authors.forename: Eugenio B
authors.initials: EB
authors.lastname: Reyes
authors.forename: Piyamitr
authors.initials: P
authors.lastname: Sritara
authors.forename: Arvind
authors.initials: A
authors.lastname: Pancholia
authors.forename: Dang
authors.initials: D
authors.lastname: Van Phuoc
authors.forename: Brian
authors.initials: B
authors.lastname: Tomlinson
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001208:Asia; D001794:Blood Pressure / Q000187:drug effects*; D032921:Consensus; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017410:Practice Guidelines as Topic
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations
keywords: Antihypertensive combination therapy; Asia-Pacific consensus; Fixed-dose combinations; Guidelines; Hypertension