title: DNA polymerases β and λ and their roles in cell.
abstract: Among the set of mammalian DNA polymerases, DNA polymerases belonging to the X and Y families have a special place. The majority of these enzymes are involved in repair, including base excision repair and non-homologous end joining. Some of them play a crucial role during the specific process which is referred to as translesion synthesis (TLS). TLS intends for the cell surviving during the replication of damaged DNA templates. Additionally, specific activities of TLS-polymerases have to be useful for repair of double-stranded clustered lesions: if the synthesis is proceeded via base excision repair process, the role of DNA polymerases β or λ will be important. In this review we discussed the biochemical properties and functional relevance of X family DNA polymerases β and λ.
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev Av., 630090 Novosibirsk, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Belousova
authors.affiliation: Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev Av., 630090 Novosibirsk, Russia; Novosibirsk State University, 2 Pirogova Street, 630090 Novosibirsk, Russia; Altay State University, 61 Lenin Av., 656049 Barnaul, Russia. Electronic address: lavrik@niboch.nsc.ru.
authors.forename: O I
authors.initials: OI
authors.lastname: Lavrik
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D019951:DNA Polymerase beta / Q000378:metabolism* / Q000502:physiology; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans
chemical_list: D004247:DNA; C415367:DNA polymerase beta2; D019951:DNA Polymerase beta
keywords: Clustered damage; DNA polymerases β and λ; PCNA; Replication protein A (RPA); Translesion synthesis (TSL)