title: MicroRNA Regulation of Embryonic Stem Cell Pluripotency and Differentiation.
abstract: Embryonic stem cells (ES cells) hold great potential for regenerative medicine. Grasp of the underlying elaborate machinery is required for clinical application. MicroRNAs serve as important post-transcriptional regulators of various normal and pathological processes. Substantial headway has been made in deciphering miRNAs' roles in establishment, maintenance and exit from pluripotency in ES cells. Here, we summarize current and ongoing research on microRNAs' roles of pluripotency maintenance and germ layer specification and possible mechanism to script the cell fate.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Xuedong
authors.initials: X
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China. liwei.zheng@scu.edu.cn.
authors.forename: Liwei
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D053595:Embryonic Stem Cells / Q000378:metabolism* / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology; D039904:Pluripotent Stem Cells / Q000378:metabolism / Q000502:physiology
chemical_list: D035683:MicroRNAs