title: Effects of glutamate and its metabotropic receptors class 1 antagonist in appetitive taste memory formation.
abstract: Cortical glutamatergic activity is known to be important for memory formation in different learning tasks. For example, glutamate activity in the insular cortex plays an important role in aversive taste memory formation by signaling the unconditioned stimulus. However, the role of glutamate in the insular cortex in appetitive taste learning has remained poorly studied. Therefore, we considered the function of glutamate in attenuation of neophobia, a model of appetitive taste recognition memory. For this purpose, we performed infusions of vehicle, glutamate, a specific mGluR1 antagonist (AIDA) or a combination of glutamate and AIDA at 0 or 30 min, and glutamate or vehicle at 60 min after novel saccharin consumption. Glutamate infusion impaired appetitive taste recognition memory when infused at 0 or 30 min, whereas, AIDA infusions produced enhanced appetitive memory at the same infusion times. Furthermore, when glutamate and AIDA were infused together no effect on attenuation of neophobia was observed. As opposed to shorter infusion times, the administration of glutamate 60 min after the presentation of the saccharin consumption was ineffective in the impairment of the appetitive taste memory. These results are discussed in view of the effect of glutamate and its mGluR1 during the appetitive taste recognition memory formation in the insular cortex.
authors.affiliation: División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, A.P. 70-253 México D.F., 04510, Mexico. Electronic address: llugo@ifc.unam.mx.
authors.forename: Leticia
authors.initials: L
authors.lastname: Ramírez-Lugo
authors.affiliation: División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, A.P. 70-253 México D.F., 04510, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Zavala-Vega
authors.affiliation: División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, A.P. 70-253 México D.F., 04510, Mexico.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Pedroza-Llinas
authors.affiliation: División de Ciencias de la Salud, Universidad de Quintana Roo, Chetumal, Quintana Roo, 77019, Mexico.
authors.forename: Luis
authors.initials: L
authors.lastname: Núñez-Jaramillo
authors.affiliation: División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, A.P. 70-253 México D.F., 04510, Mexico. Electronic address: fbermude@ifc.unam.mx.
authors.forename: Federico
authors.initials: F
authors.lastname: Bermúdez-Rattoni
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002408:Catheters, Indwelling; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology*; D007189:Indans / Q000494:pharmacology; D008845:Microinjections; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D012439:Saccharin / Q000008:administration & dosage; D055697:Taste Perception / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: C095756:1-aminoindan-1,5-dicarboxylic acid; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D007189:Indans; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D018698:Glutamic Acid; D012439:Saccharin
keywords: AIDA; Appetitive taste memory; Attenuation of neophobia; Learning; Metabotropic glutamatergic receptors