title: A patient developing anaphylaxis and sensitivity to two different GnRH analogues and a review of literature.
abstract: Gonadotropin-releasing hormone analogues are used in the treatment of prostate cancer, breast cancer, endometriosis, and uterine leiomyomas in adults and often in the treatment of precocious puberty in children. Many adverse effects have been reported for gonadotropin-releasing hormone analogues, but anaphylaxis is rarely reported as an adverse effect. Frequent cross-reactions, particularly during childhood, and diversity of the time of onset of anaphylactic manifestations complicate the diagnosis. A patient who exhibited anaphylactic allergic reactions to two different agents used in the treatment of central precocious puberty presented here because the case has an atypical course and is the first in the literature.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ökdemir
authors.forename: Nihal
authors.initials: N
authors.lastname: Hatipoğlu
authors.forename: Himmet Haluk
authors.initials: HH
authors.lastname: Akar
authors.forename: Ülkü
authors.initials: Ü
authors.lastname: Gül
authors.forename: Leyla
authors.initials: L
authors.lastname: Akın
authors.forename: Fulya
authors.initials: F
authors.lastname: Tahan
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoğlu
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects*; D011379:Prognosis; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate; D016729:Leuprolide