title: Potential dual imaging nanoparticle: Gd2O3 nanoparticle.
abstract: Gadolinium (Gd) is a unique and powerful element in chemistry and biomedicine which can be applied simultaneously to magnetic resonance imaging (MRI), X-ray computed tomography (CT), and neutron capture therapy for cancers. This multifunctionality can be maximized using gadolinium oxide (Gd2O3) nanoparticles (GNPs) because of the large amount of Gd per GNP, making both diagnosis and therapy (i.e., theragnosis) for cancers possible using only GNPs. In this study, the T1 MRI and CT dual imaging capability of GNPs is explored by synthesizing various iodine compound (IC) coated GNPs (IC-GNPs). All the IC-GNP samples showed stronger X-ray absorption and larger longitudinal water proton relaxivities (r1 = 26-38 s(-1) mM(-1) and r2/r1 = 1.4-1.9) than the respective commercial contrast agents. In vivo T1 MR and CT images of mice were also acquired, supporting that the GNP is a potential dual imaging agent.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
authors.forename: Md Wasi
authors.initials: MW
authors.lastname: Ahmad
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea.
authors.forename: Sung June
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Molecular Medicine and Medical &Biological Engineering, School of Medicine, KNU, Taegu 702-701, South Korea.
authors.forename: Jong Su
authors.initials: JS
authors.lastname: Baeck
authors.affiliation: 1] Department of Molecular Medicine and Medical &Biological Engineering, School of Medicine, KNU, Taegu 702-701, South Korea [2] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Bae
authors.affiliation: 1] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea [2] Department of Biology Education, Teacher's College, KNU, Taegu 702-701, South Korea.
authors.forename: Kwon Seok
authors.initials: KS
authors.lastname: Chae
authors.affiliation: Laboratory of Nuclear Medicine Research, Molecular Imaging Research Center, Korea Institute of Radiological Medical Science, Nowon-gil 75, Seoul 139-706, South Korea.
authors.forename: Ji Ae
authors.initials: JA
authors.lastname: Park
authors.affiliation: Institute of Biomedical Engineering Research, Kyungpook National University, Taegu 702-701, South Korea.
authors.forename: Tae Jeong
authors.initials: TJ
authors.lastname: Kim
authors.affiliation: 1] Department of Chemistry, College of Natural Sciences, Kyungpook National University (KNU), Taegu 702-701, South Korea [2] Department of Nanoscience and Nanotechnology, KNU, Taegu 702-701, South Korea.
authors.forename: Gang Ho
authors.initials: GH
authors.lastname: Lee