title: Evaluation of sarcopenia in renal transplant recipients.
abstract: BACKGROUND
  Chronic kidney disease can lead to sarcopenia; however, no study has described sarcopenia in the patients undergoing renal transplantation.
  
  
  OBJECTIVE
  The aim of the present study was to assess the prevalence of sarcopenia in renal transplant recipients (RTR) and to evaluate the demographic and metabolic risk factors associated with sarcopenia in these patients.
  
  
  METHODS
  Sarcopenia was diagnosed by measuring handgrip strength in 166 RTR (68 females and 98 males; mean age, 37.9 ± 11.9 years). Basal metabolic rate, fat mass, free-fat mass, total body water, body mass index, and calf circumference were determined, along with blood biochemistry, vitamin D levels, and glomerular filtration rate.
  
  
  RESULTS
  Among 166 patients, sarcopenia was present in 34 (20.5%). Handgrip, basal metabolic rate, free fat mass, and total body water were significantly lower in patients with sarcopenia in comparison with those without sarcopenia. There were no differences between patients with and without sarcopenia in terms of mean time since transplantation, the presence of diabetes mellitus, hypertension, coronary artery disease, hyperlipidemia, glomerular filtration rate, and body mass index. Univariate analysis revealed significant differences between patients with and without sarcopenia with respect to age (mean of 43.70 ± 13.97 and 36.37 ± 10.82 years, respectively; P = 0.007) and 25-OH vitamin D levels (median (IQR) of 12 (2-39) and 17.70 (3-68) μg/L, respectively; P = 0.024). There was a statistically significant positive correlation between vitamin D levels and handgrip strength (r = 0.334; P < 0.001). Multivariate regression analysis determined that age was an independent predictive variable of sarcopenia in RTR (β = 1.060; 95% CI, 1.017-1.105; and P = 0.006).
  
  
  CONCLUSIONS
  Chronic renal disease contributes to sarcopenia, which may develop at an earlier age in RTR.
authors.affiliation: Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozkayar
authors.affiliation: Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Altun
authors.affiliation: Division of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Halil
authors.affiliation: Division of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Kuyumcu
authors.affiliation: Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Gunes
authors.initials: G
authors.lastname: Arik
authors.affiliation: Division of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yesil
authors.affiliation: Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Yildirim
authors.affiliation: Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Rahmi
authors.initials: R
authors.lastname: Yilmaz
authors.affiliation: Division of Geriatric Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Ariogul
authors.affiliation: Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Turgan
keywords: Muscle Strength; Renal Transplantation; Sarcopenia