title: Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.
abstract: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The first broad-spectrum multicomponent vaccine against serogroup B meningococcus (MenB), 4CMenB (Bexsero(®)), was approved by the EMA in 2013, for prevention of MenB disease in all age groups, and by the US FDA in January 2015 for use in adolescents. A second protein-based MenB vaccine has also been approved in the USA for adolescents (rLP2086, Trumenba(®)). Both vaccines contain the lipoprotein factor H-binding protein (fHbp). Preclinical studies demonstrated that fHbp elicits a robust bactericidal antibody response that correlates with the amount of fHbp expressed on the bacterial surface. fHbp is able to selectively bind human factor H, the key regulator of the alternative complement pathway, and this has important implications both for meningococcal pathogenesis and for vaccine design. Here, we review the functional and structural properties of fHbp, the strategies that led to the design of the two fHbp-based vaccines and the data generated during clinical studies.
authors.affiliation: Institute for Glycomics, Griffith University, Southport, Queensland, 4215, Australia.
authors.forename: Kate L
authors.initials: KL
authors.lastname: Seib
authors.forename: Maria
authors.initials: M
authors.lastname: Scarselli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Comanducci
authors.forename: Daniela
authors.initials: D
authors.lastname: Toneatto
authors.forename: Vega
authors.initials: V
authors.lastname: Masignani
mesh_terms: D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D006801:Humans; D008589:Meningococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology* / Q000302:isolation & purification; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology*; D014481:United States / Q000453:epidemiology; D037521:Virulence Factors / Q000276:immunology*
chemical_list: C570015:4CMenB vaccine; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D022401:Meningococcal Vaccines; D037521:Virulence Factors; C484699:factor H-binding protein, Neisseria meningitidis
keywords: 4CMenB; Bexsero vaccine; Trumenba vaccine; factor H-binding protein; rLP2086