title: [Role of kidney injury molecule-1 (KIM-1) for inhospital event risk assessment after coronary artery bypass surgery].
abstract: OBJECTIVE
  To assess value of kidney injury molecule-1 (KIM-1) for prediction of inhospital events in CAD patients undergoing coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  We analyzed postoperative course of 719 patients subjected to CABG in Research Institute for Complex Issues of Cardiovascular Diseases between March, 2011 and April, 2012. In all patients we measured creatinine concentrations, glomerular filtration rate (GFR) by MDRD and urine KIM-1 levels before and on day 7 after CABG. Major unfavorable events (myocardial infarction, stroke or transient ischemic attack, acute or decompensated chronic renal failure or remediastinotomy) were registered during hospital stay. The EuroSCORE (European System for Cardiac Operative Risk Evaluation) risk of operative mortality was calculated for each patient.
  
  
  RESULTS
  Patients with different EuroSCORE risk had similar serum creatinine levels while KIM-1 concentrations in urine were significantly higher in patients with moderate and high EuroSCORE risk as compared with low-risk patients. Patients who experienced postoperative events had significantly higher KIM-1 both before and after surgery while there were no differences in such renal dysfunction markers as creatinine and GFR.
  
  
  CONCLUSIONS
  Preoperative elevated KIM-1 can act as a marker of complicated postoperative period after CABG.
authors.forename: K S
authors.initials: KS
authors.lastname: Shafranskaia
authors.forename: E G
authors.initials: EG
authors.lastname: Uchasova
authors.forename: D A
authors.initials: DA
authors.lastname: Sumin
authors.forename: K E
authors.initials: KE
authors.lastname: Krivoshapova
authors.forename: V V
authors.initials: VV
authors.lastname: Kalaeva
authors.forename: M V
authors.initials: MV
authors.lastname: Evseeva
authors.forename: V N
authors.initials: VN
authors.lastname: Karetnikova
authors.forename: O L
authors.initials: OL
authors.lastname: Barbarash
authors.forename: L S
authors.initials: LS
authors.lastname: Barbarash
mesh_terms: D015415:Biomarkers / Q000652:urine; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D005260:Female; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods; D008297:Male; D008562:Membrane Glycoproteins / Q000652:urine*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery; D017063:Outcome Assessment, Health Care; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D011991:Receptors, Virus; D051437:Renal Insufficiency / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D012800:Siberia; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism
chemical_list: D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D008562:Membrane Glycoproteins; D011991:Receptors, Virus