title: Heparan sulfate provides a mechanism to respond to FGFR2b and control regenerative expansion.
abstract: Fast varying 3-O-sulfated groups in epithelial KIT+ progenitors provides a cellular mechanism to respond to FGFR2b-mediated signaling and expansion of fetal and adult progenitors. This is allowed by the synthesis of 3-O-sulfated heparan sulfate that up-regulate KIT and 3-O-sulfotransferase enzymes, augmenting 3-O-sulfated heparan sulfate.
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago, Chile, ebrandan@bio.puc.cl.
authors.forename: Enrique
authors.initials: E
authors.lastname: Brandan