title: Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones: application to the synthesis of substituted furans.
abstract: A novel Bi(OTf)3-mediated cycloisomerization of γ-alkynyl arylketones 4, 7, or 10 with molecular sieve (MS) in MeNO2 affords 3-substituted furans 3, 8, or 11 at rt for 3 h in moderate to good yields. The method provides mild, less-toxic, atom-economic and efficient conditions. The mechanism has been studied and proposed. Moreover, this route can be enlarged to gram scale.
authors.affiliation: Department of Medicinal and Applied Chemistry, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Meng-Yang
authors.initials: MY
authors.lastname: Chang
authors.forename: Yu-Chieh
authors.initials: YC
authors.lastname: Cheng
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Lu
mesh_terms: D000480:Alkynes / Q000737:chemistry; D003500:Cyclization; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007536:Isomerism; D007659:Ketones / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D005663:Furans; D007659:Ketones; D008698:Mesylates; C445789:Bi(OTf)3