title: Role of 5-HT2 receptors in diabetes: Swertiamarin seco-iridoid glycoside might be a possible 5-HT2 receptor modulator.
abstract: In the present review, we are focusing on modulators of 5-HT2 receptors, swertiamarin and their role in diabetes. These drugs possess both central and peripheral actions in various animal models of depression, diabetes and obesity. Swertiamarin and 5-HT2 antagonist are reported antidepressant, hypolipidemic and beneficial in peripheral vasculopathy. In contrast to this, 5-HT2C selective agonist decreases hyperglycemia, hyperlipidemia and insulin secretogogue by action. Selective serotonin reuptake inhibitors (SSRIs) are known antidepressant having weight gain as an adverse effect. Swertiamarin has similar pharmacological actions as 5-HT2 antagonist and 5-HT2C selective agonist. This warrants that swertiamarin might modulate 5-HT2 receptors rather than affecting the uptake of serotonin. In the light of present investigation, the mechanism of these drugs can correlate the role of central and peripheral 5-HT2 receptors in diabetes.
authors.affiliation: Department of Pharmacology, R.C. Patel Institute of Pharmaceutical Education and Research (RCPIPER), Karvand naka, Shirpur, Maharashtra 425205, India; Pharmacy Department, The M.S. University of Baroda, Vadodara, Gujarat 390001, India. Electronic address: rakesh12283@gmail.com.
authors.forename: Rakesh Deelip
authors.initials: RD
authors.lastname: Sonawane
authors.affiliation: Medicinal Chemistry Department, Piramal Enterprises Limited, 1 Nirlon Complex, Off Western Express Highway, Goregaon (E), Mumbai, Maharashtra 400063, India. Electronic address: vijaykumardeore@yahoo.co.in.
authors.forename: Vijaykumar B
authors.initials: VB
authors.lastname: Deore
authors.affiliation: Department of Pharmacology, H.R. Patel Institute of Pharmaceutical Education and Research (HRPIPER), Karvand naka, Shirpur, Maharashtra 425205, India.
authors.forename: Savita D
authors.initials: SD
authors.lastname: Patil
authors.affiliation: Department of Pharmacology, R.C. Patel Institute of Pharmaceutical Education and Research (RCPIPER), Karvand naka, Shirpur, Maharashtra 425205, India.
authors.forename: Chandragouda R
authors.initials: CR
authors.lastname: Patil
authors.affiliation: Department of Pharmacology, R.C. Patel Institute of Pharmaceutical Education and Research (RCPIPER), Karvand naka, Shirpur, Maharashtra 425205, India. Electronic address: sjsurana@yahoo.com.
authors.forename: Sanjay J
authors.initials: SJ
authors.lastname: Surana
authors.affiliation: Pharmacy Department, The M.S. University of Baroda, Vadodara, Gujarat 390001, India; V ClinBio Labs, Sri Ramachandra University & Hospital, Porur, Chennai, Tamil Nadu 600116, India. Electronic address: goyalrk@gmail.com.
authors.forename: Ramesh K
authors.initials: RK
authors.lastname: Goyal
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000523:psychology; D006801:Humans; D057888:Iridoid Glucosides / Q000737:chemistry / Q000627:therapeutic use*; D011753:Pyrones / Q000737:chemistry / Q000627:therapeutic use*; D044348:Receptors, Serotonin, 5-HT2 / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D057888:Iridoid Glucosides; D011753:Pyrones; D044348:Receptors, Serotonin, 5-HT2; C013270:swertiamarin
keywords: 5-HT2 receptor; Anti-depressant; Diabetes; Serotonin; Swertiamarin and receptor modulators