title: Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015.
abstract: Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K(+) currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Hiyoung
authors.initials: H
authors.lastname: Kim
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Inho
authors.initials: I
authors.lastname: Yang
authors.affiliation: ‡National Research Laboratory for Cell Physiology and Department of Physiology, Seoul National University College of Medicine, 28 Yonkeun-Dong, Chongno-Ku, Seoul 110-799, Korea.
authors.forename: Shin-Young
authors.initials: SY
authors.lastname: Ryu
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Won
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Awadut G
authors.initials: AG
authors.lastname: Giri
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Weihong
authors.initials: W
authors.lastname: Wang
authors.affiliation: §College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 712-749, Korea.
authors.forename: Hyukjae
authors.initials: H
authors.lastname: Choi
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Jungwook
authors.initials: J
authors.lastname: Chin
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Dongyup
authors.initials: D
authors.lastname: Hahn
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Eunhee
authors.initials: E
authors.lastname: Kim
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Chulkyeong
authors.initials: C
authors.lastname: Han
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.affiliation: ⊥Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 120-750, Korea.
authors.forename: Sang-Jip
authors.initials: SJ
authors.lastname: Nam
authors.affiliation: ‡National Research Laboratory for Cell Physiology and Department of Physiology, Seoul National University College of Medicine, 28 Yonkeun-Dong, Chongno-Ku, Seoul 110-799, Korea.
authors.forename: Won-Kyung
authors.initials: WK
authors.lastname: Ho
authors.affiliation: †Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea.|∥Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea.
authors.forename: Heonjoong
authors.initials: H
authors.lastname: Kang
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology*; D026902:Potassium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D001577:Benzophenones; D007328:Insulin; D026902:Potassium Channel Blockers; C000598720:acredinone A; C000598721:acredinone B