title: [Successful anesthetic management of laparoscopic rectopexy using rocuronium and sugammadex in a patient with Becker muscular dystrophy].
abstract: A 70-year-old man with Becker muscular dystrophy (BMD) underwent laparoscopic rectopexy under general anesthesia. For anesthetic induction, we administered total 0.6 mg · kg-1 of rocuronium with titration. Eight minutes later, train-of-four (TOF) count reached to 0 and the patient was intubated smoothly. One hundred and five minutes later, TOF ratio recovered to 100% and we administered rocuronium 10 mg additionally. Surgery was finished without any problems 95 minutes after thereafter. TOF ratio was 45% and we administered sugammadex 3 mg · kg-1, reversing neuromuscular blockade to TOF ratio 100% within 1.5 minute. The patient awoke clearly and respiratory condition was good. He was extubated without remaining neuromuscular blockade. Postoperative course was stable and there was no serious adverse effect on his muscular function intra- and post-operatively. In conclusion, rocuronium and sugammadex can be used safely and effectively in general anesthetic management for patients with muscular dystrophy. However, as the onset times and durations of these agents can be longer, we should administer these agents with titration carefully under periodic neuromuscular monitoring.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Giichiro
authors.initials: G
authors.lastname: Ohno
authors.forename: Jiro
authors.initials: J
authors.lastname: Kitamura
mesh_terms: D000368:Aged; D000732:Androstanols / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D013505:Digestive System Surgical Procedures; D006801:Humans; D010535:Laparoscopy; D008297:Male; D009136:Muscular Dystrophies / Q000601:surgery*; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D019990:Perioperative Care; D012005:Rectal Prolapse / Q000601:surgery*; D000077123:Rocuronium; D000077122:Sugammadex; D047408:gamma-Cyclodextrins / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D000077123:Rocuronium