title: miRNAs in inflammatory skin diseases and their clinical implications.
abstract: miRNAs are a class of non-coding RNA molecules that modulate gene expression post-transcriptionally. They have a major impact on several physiological and pathological cellular processes including modulation of the innate and the adaptive immune system. The role of miRNAs in skin biology is still incomplete; however, it is known that miRNAs are implicated in various cellular processes of both normal and diseased skin. Some miRNAs appear to be consistently deregulated in several different inflammatory skin diseases, including psoriasis and atopic dermatitis, indicating a common role in fundamental biological processes. The clinical implications of miRNAs are intriguing, both from a diagnostic and a therapeutic perspective. Accordingly, there is emerging evidence for the clinical potential of miRNAs as both biomarkers and possible therapeutic targets in skin diseases. Future studies will hopefully establish the biological significance of miRNAs in skin biology, paving the way for new miRNA-based diagnostic and therapeutic applications in dermatology.
authors.affiliation: Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Kildegårdsvej 28, 2900 Hellerup, Denmark.
authors.forename: Marianne B
authors.initials: MB
authors.lastname: Løvendorf
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001691:Biological Therapy / Q000639:trends*; D015415:Biomarkers / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D035683:MicroRNAs / Q000378:metabolism*; D011565:Psoriasis / Q000175:diagnosis / Q000276:immunology*; D012867:Skin / Q000276:immunology*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: allergic contact dermatitis; atopic dermatitis; biomarkers; miRNAs; non-coding RNA; psoriasis