title: Efficacy of Xuebijing for coagulopathy in patients with sepsis.
abstract: OBJECTIVE
  To provide evidence of the clinical efficacy of Xuebijing (XBJ) on blood coagulation in patients with sepsis.
  
  
  METHODS
  We conducted this meta-analysis in The People's Hospital of Liaoning Province, Shenyang, China between December 2013 and May 2014. We searched a number of databases for relevant randomized controlled trials (RCTs) published before December 2013 using the keywords 'Xuebijing', 'coagulation' and 'sepsis'. Statistical analysis was performed with Review Manager 5.2 from the Cochrane Collaboration.
  
  
  RESULTS
  Fourteen RCTs involving 867 patients were included. Compared with placebo, XBJ injection significantly improved platelets (mean differences [MD] = 42.14, 95% confidence interval [CI]: 22.42 - 61.86, p<0.00001), shortened the activated partial thromboplastin time (MD = -4.81, 95% CI: -7.86 - [-1.76], p=0.002), shortened the prothrombin time (MD = -2.33, 95% CI: -4.15 - [-0.51], p=0.01), and shortened the thrombin time (MD = -2.05, 95% CI: -3.52 - [-0.58], p=0.006). However, no significant difference was found between the XBJ injection and the placebo group for fibrinogen (MD = 0.21, 95% CI: -0.38 - 0.81, p=0.48).
  
  
  CONCLUSIONS
  Xuebijing injection may improve coagulopathy in patients with sepsis. High-quality and large sample clinical trials are needed for confirmation.
authors.affiliation: Department of Intensive Care Unit, The People's Hospital of Liaoning Province, No. 33, Wenyi Road, Shenhe District, Shenyang 110022, Liaoning, China. E-mail. siyuan_0525@163.com.
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Hou
authors.forename: Xing-Huo
authors.initials: XH
authors.lastname: Feng
authors.forename: Chang-Liang
authors.initials: CL
authors.lastname: Lin
authors.forename: Yong-Feng
authors.initials: YF
authors.lastname: Tan
mesh_terms: D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D018805:Sepsis / Q000150:complications*
chemical_list: D004365:Drugs, Chinese Herbal; C549376:Xuebijing