title: Asthma and Allergies in Children With Autism Spectrum Disorders: Results From the CHARGE Study.
abstract: Immune aberrations are often noted in children with autism spectrum disorder (ASD), but whether asthma and allergy are related to ASD is not well defined. This study examined asthma and allergies in association with ASD and phenotypic subsets. Participants were 560 children with confirmed ASD and 391 typically developing children from the CHildhood Autism Risks from Genetics and the Environment study. Maternally reported child asthma and allergy was compared between cases and controls, and in association with cognitive and behavioral test scores. Prevalence of asthma and overall allergies did not differ between cases and controls, but overall allergy in children with ASD was associated with higher stereotypy scores as measured by the Aberrant Behavior Checklist. In addition, reported food allergies were significantly associated with ASD (adjusted odds ratio = 2.23, 95% confidence interval 1.28, 3.89). Our results suggest food allergies and sensitivities may be more common in children with ASD, and that these issues may correlate with other behaviors.
authors.affiliation: Department of Public Health Sciences, Univeristy of California, Davis, California, 95616 (K.L., I.H.P.).
authors.forename: Kristen
authors.initials: K
authors.lastname: Lyall
authors.affiliation: University of California, Davis, MIND Institute, Sacramento, California, 95817 (J.V.W., P.A., I.H.P.).
authors.forename: Judy
authors.initials: J
authors.lastname: Van de Water
authors.affiliation: University of California, Davis, MIND Institute, Sacramento, California, 95817 (J.V.W., P.A., I.H.P.).
authors.forename: Paul
authors.initials: P
authors.lastname: Ashwood
authors.affiliation: Department of Public Health Sciences, Univeristy of California, Davis, California, 95616 (K.L., I.H.P.).|University of California, Davis, MIND Institute, Sacramento, California, 95817 (J.V.W., P.A., I.H.P.).
authors.forename: Irva
authors.initials: I
authors.lastname: Hertz-Picciotto
mesh_terms: D001249:Asthma / Q000453:epidemiology*; D000067877:Autism Spectrum Disorder / Q000453:epidemiology*; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012306:Risk
keywords: allergy; asthma; autism; food allergy