title: Synthesis and anti-cancer activity evaluation of new aurone derivatives.
abstract: In this study, we have synthesized 2-[3- or 4-(2-aryl-2-oxoethoxy)arylidene]benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions using benzofuranon-3-one derivatives (A1-A4, B) as starting materials which were gained in various synthetic ways. Aurone derivatives (C1-C10) were acquired with the condensation reaction of these starting materials and 3-/4-hydroxybenzaldehyde which were then reacted with α-bromoacetophenones to get final compounds. The anti-cancer activity of the selected compounds was performed by National Cancer Institute (NCI), USA against 60 human tumor cell lines derived from nine neoplastic diseases. Compounds exhibited anti-cancer activity in varying ratios.
authors.affiliation: a Department of Pharmaceutical Chemistry , School of Pharmacy, Medipol University , Istanbul , Turkey .
authors.forename: Seref
authors.initials: S
authors.lastname: Demirayak
authors.forename: Leyla
authors.initials: L
authors.lastname: Yurttas
authors.forename: Nalan
authors.initials: N
authors.lastname: Gundogdu-Karaburun
authors.forename: Ahmet Cagri
authors.initials: AC
authors.lastname: Karaburun
authors.forename: Ismail
authors.initials: I
authors.lastname: Kayagil
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; C486837:aurone
keywords: Anti-cancer activity; NCI; aurone; benzofuranone; synthesis