title: Polyphenols in Regulation of Redox Signaling and Inflammation During Cardiovascular Diseases.
abstract: Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardiovascular diseases as well as genome wide association studies were successful in indentifying the loci associated with this prominent life-threatening disease but still a substantial amount of casualty remains unexplained. Over the last decade, the thorough understanding of molecular and biochemical mechanisms of cardiac disorders lead to the knowledge of various mechanisms of action of polyphenols to target inflammation during cardiac disorders. The present review article summarizes major mechanisms of polyphenols against cardiovascular diseases.
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Niu
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: He
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China.
authors.forename: Zhen-Zhou
authors.initials: ZZ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Xuzhou Children's Hospital, 18 Sudi North Road, Xuzhou, 221006, China. contribution071@163.com.
authors.forename: Xin-Jiang
authors.initials: XJ
authors.lastname: An
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D059808:Polyphenols / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D016328:NF-kappa B; D059808:Polyphenols; D017382:Reactive Oxygen Species
keywords: Cardiovascular diseases; Polyphenols; Redox signaling