title: [Metabolic syndrome and melatonin].
abstract: Metabolic syndrome (MS) is characterized by the following symptoms: obesity, AH, dyslipidemia, insulin resistance. Pathophysiologically, MS is underlain by disorders of many biochemical and physiological processes, such as elevated levels of low density lipoproteins, hyperstimulation of pancreatic b-cells, increased insulin secretion, substitution of lipid metabolism for carbohydrate one, overgrowth of adipose tissue, excess production of adiponectin, leptin and other signal molecules and a rise in their local intravascular concentration, weight gain. Endogenous and exogenous melatonin inhibits these pathophysiological mechanisms, normalizes metabolism, equilibrates insulin secretion, prevents pancreatic hyperfunction, phosphorylates insulin receptors, inactivates active oxygen and nitrogen species including those produced in LDLP metabolism. Melatonin has specific MT1 and MT2 receptors localized in all body cells. Due to this, it exerts combined preventive action in patients with MS. Recently, melatonin has been reported to have therapeutic effect in MS; it may be recommended to treat this condition.
authors.forename: S I
authors.initials: SI
authors.lastname: Rapoport
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Molchanov
authors.forename: V A
authors.initials: VA
authors.lastname: Golichenkov
authors.forename: O V
authors.initials: OV
authors.lastname: Burlakova
authors.forename: E S
authors.initials: ES
authors.lastname: Suprunenko
authors.forename: E S
authors.initials: ES
authors.lastname: Savchenko
mesh_terms: D006801:Humans; D008550:Melatonin / Q000502:physiology* / Q000627:therapeutic use; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D008550:Melatonin