title: Effect of desipramine on gene expression in the mouse frontal cortex - microarray study.
abstract: BACKGROUND
  These studies aimed to identify the genes differentially expressed in the frontal cortex of mice treated repeatedly with either saline or desipramine (DMI).
  
  
  METHODS
  Differences in gene expression in the mouse frontal cortex were studied using a whole-genome microarray approach.
  
  
  RESULTS
  The analyses revealed a group of 88 transcripts (18 genes) that were differentially expressed between the mice treated with saline and those treated with DMI. These genes include Spnb2, Mef2c, Ncam1, Hsp90ab1, Kif1b, Ddx6 and Gsk3b, which were connected in the gene relationship network.
  
  
  CONCLUSIONS
  It appears that one week of DMI administration measurably altered the expression of a small number of genes, including genes connected with neuroplasticity and cytoskeletal changes, the regulation of calcium levels in the cell or translation processes.
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland. Electronic address: solich@if-pan.krakow.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Solich
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kolasa
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Kuśmider
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Faron-Górecka
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Pabian
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Kinga
authors.initials: K
authors.lastname: Szafran
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Żurawek
authors.affiliation: Department of Pharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Dziedzicka-Wasylewska
mesh_terms: D000818:Animals; D003891:Desipramine / Q000494:pharmacology*; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects*; D020869:Gene Expression Profiling; D008297:Male; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D003891:Desipramine
keywords: Desipramine; Gene expression; Mice; Microarray