title: Antihypoxic activity of cycloprolylglycine analogs.
abstract: We studied antihypoxic activity of analogs of endogenous cyclic dipeptide cycloprolylglycine in a mouse model of normobaric hypoxia with hypercapnia and found that antixypoxic effect depends on the structure of the substance. It was shown that different pharmacophores are responsible for the antihypoxic, nootropic, and anxiolytic effects of cycloprolylglycine.
authors.affiliation: V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, kszolotova@mail.ru.
authors.forename: K N
authors.initials: KN
authors.lastname: Kolyasnikova
authors.forename: G A
authors.initials: GA
authors.lastname: Nazarova
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D006935:Hypercapnia / Q000188:drug therapy*; D000860:Hypoxia / Q000188:drug therapy*; D051379:Mice; D015394:Molecular Structure; D018697:Nootropic Agents / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D018709:Statistics, Nonparametric
chemical_list: D014151:Anti-Anxiety Agents; D018697:Nootropic Agents; D010456:Peptides, Cyclic; C062238:cyclo(prolylglycyl)