title: Association of cinnarizine and betahistine in prophylactic therapy for Ménière's disease with and without migraine.
abstract: Prophylactic therapy of Ménière's disease (MD) includes betahistine and calcium-blockers (the latter also useful for migraine prevention). The aim of our work was to assess the efficacy of combined therapy with cinnarizine and betahistine in MD subjects both with and without migraine and poorly responsive to betahistine alone. Fifty-two MD subjects were included who were poorly responsive to betahistine during 6 months of follow-up; 29 were migraineurs. Combined therapy was administered with betahistine 48 mg/day and cinnarizine 20 mg BID for 1 month, 20 mg/day for 2 weeks and 20 mg every 2 days for 2 more weeks, and then repeated. Results were collected over 6 months of follow-up. MD subjects with and without migraine demonstrated a decrease in both vertigo spells and migrainous attacks during combined therapy (from 9.4 to 3.8 and from 6.8 to 5.9 in 6 months, respectively, for vertigo spells, while migraine decreased from 3.8 to 1 in 6 months, respectively). A correlation was seen between decrease of vertigo spells and headaches in the sample of MD subjects with migraine. Our data support a proactive role for cinnarizine in preventing vertigo spells, especially in MD patients with migraine.
authors.affiliation: Division of ENT, San Raffaele Scientific Institute, Milan, Italy;
authors.forename: R
authors.initials: R
authors.lastname: Teggi
authors.affiliation: Division of ENT, San Raffaele Scientific Institute, Milan, Italy;
authors.forename: O
authors.initials: O
authors.lastname: Gatti
authors.affiliation: Division of ENT, San Raffaele Scientific Institute, Milan, Italy;
authors.forename: V
authors.initials: V
authors.lastname: Sykopetrites
authors.affiliation: Division of ENT, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Quaglieri
authors.affiliation: Division of ENT, IRCCS Policlinico San Matteo Foundation, University of Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Benazzo
authors.affiliation: Division of ENT, San Raffaele Scientific Institute, Milan, Italy;
authors.forename: M
authors.initials: M
authors.lastname: Bussi
mesh_terms: D001621:Betahistine / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002936:Cinnarizine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000517:prevention & control*; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications; D014717:Vertigo / Q000150:complications
chemical_list: D002121:Calcium Channel Blockers; D002936:Cinnarizine; D001621:Betahistine
keywords: Betahistine; Calcium-Blockers; Cinnarizine; Migraine; Ménière's Disease; Therapy