title: Clinical Characteristics of Patients on Hemodialysis With Peripheral Arterial Disease.
abstract: Patients on hemodialysis (HD; n = 210) were examined for peripheral arterial disease (PAD) using ankle-brachial index (ABI) and toe-brachial index (TBI). The prevalence of PAD was 38.1%. Among patients with PAD, 87.5% were newly diagnosed with PAD, 42.5% were diagnosed with TBI <0.6 despite ABI ≥ 0.9, and 68.7% had no lower limb symptoms. In patients with PAD, the prevalence rate of cerebrovascular disease was 36.3%, coronary artery disease was 42.5%, spinal stenosis was 33.2%, and vertebral fracture 15.0% and was significantly higher than those of the non-PAD patients. Low high-density lipoprotein cholesterol was the most important biomarker among patients with PAD. PAD has been underdiagnosed and untreated in patients on HD because most patients do not have symptoms that could be due to diabetic neuropathy or have insufficient daily activity to experience exertional leg symptoms. Screening for PAD using the ABI and TBI increased diagnostic efficiency in patients on HD and may lead to effective early treatments, including pharmacotherapy, revascularization therapy, and exercise rehabilitation to avoid the worst possible scenario such as lower limb amputation, cardiovascular event, and death.
authors.affiliation: Department of Rehabilitation, Kitasato University Hospital, Sagamihara, Japan.
authors.forename: Ryota
authors.initials: R
authors.lastname: Matsuzawa
authors.affiliation: Department of Cardio-angiology, Kitasato University, School of Medicine, Sagamihara, Japan aoyama@med.kitasato-u.ac.jp.
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Aoyama
authors.affiliation: Sagami Circulatory Organ Clinic, Sagamihara, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL
keywords: ankle-brachial index; arteriosclerosis; hemodialysis; peripheral arterial disease; toe-brachial index