title: A role for actin polymerization in persistent pulmonary hypertension of the newborn.
abstract: Persistent pulmonary hypertension of the newborn (PPHN) is defined as the failure of normal pulmonary vascular relaxation at birth. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial myocytes, resulting in elevation of smooth muscle α-actin and γ-actin content in elastic and resistance pulmonary arteries in PPHN compared with age-matched controls. This review examines the original histological characterization of PPHN with attention to cytoskeletal structural remodeling and actin isoform abundance, reviews the existing evidence for understanding the biophysical and biochemical forces at play during neonatal circulatory transition, and specifically addresses the role of the cortical actin architecture, primarily identified as γ-actin, in the transduction of mechanical force in the hypoxic PPHN pulmonary circuit.
authors.affiliation: Biology of Breathing Group, Manitoba Institute of Child Health, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada., Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Jena
authors.initials: J
authors.lastname: Fediuk
authors.forename: Shyamala
authors.initials: S
authors.lastname: Dakshinamurti
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D003599:Cytoskeleton / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism*; D007231:Infant, Newborn; D020033:Protein Isoforms / Q000378:metabolism; D055503:Protein Multimerization; D011651:Pulmonary Artery / Q000473:pathology
chemical_list: D000199:Actins; D020033:Protein Isoforms
keywords: HTAPPN; PPHN; alpha actin; alpha-actine; gamma actin; gamma-actine; hypoxie néonatale; neonatal hypoxia; remodelage vasculaire; vascular remodeling