title: Prognostic nomogram for overall survival in previously untreated patients with extranodal NK/T-cell lymphoma, nasal-type: a multicenter study.
abstract: The aim of this study was to develop a widely accepted prognostic nomogram for extranodal NK/T-cell lymphoma, nasal-type (NKTCL). The clinical data from 1383 patients with NKTCL treated at 10 participating institutions between 2000 and 2011 were reviewed. A nomogram was developed that predicted overall survival (OS) based on the Cox proportional hazards model. To contrast the utility of the nomogram against the widely used Ann Arbor staging system, the International Prognostic Index (IPI) and the Korean Prognostic Index (KPI), we used the concordance index (C-index) and a calibration curve to determine its predictive and discriminatory capacity. The 5-year OS rate was 60.3% for the entire group. The nomogram included five important variables based on a multivariate analysis of the primary cohort: stage; age; Eastern Cooperative Oncology Group performance status; lactate dehydrogenase; and primary tumor invasion. The calibration curve showed that the nomogram was able to predict 5-year OS accurately. The C-index of the nomogram for OS prediction was 0.72 for both cohorts, which was superior to the predictive power (range, 0.56-0.64) of the Ann Arbor stage, IPI and KPI in the primary and validation cohorts. The proposed nomogram provides an individualized risk estimate of OS in patients with NKTCL.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute, Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS), Beijing, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
authors.forename: J-Z
authors.initials: JZ
authors.lastname: Cao
authors.affiliation: Cancer Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Yuan
authors.affiliation: Cancer Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
authors.forename: L-M
authors.initials: LM
authors.lastname: Xu
authors.affiliation: Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
authors.forename: J-X
authors.initials: JX
authors.lastname: Wu
authors.affiliation: Fujian Provincial Cancer Hospital, Fuzhou, Fujian, People's Republic of China.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.affiliation: Guizhou Cancer Hospital, Guiyang, Guizhou, People's Republic of China.
authors.forename: T
authors.initials: T
authors.lastname: Wu
authors.affiliation: Guizhou Cancer Hospital, Guiyang, Guizhou, People's Republic of China.
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.affiliation: Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, Hunan, People's Republic of China.
authors.forename: S-Y
authors.initials: SY
authors.lastname: Zhu
authors.affiliation: The Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
authors.forename: L-T
authors.initials: LT
authors.lastname: Qian
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People's Republic of China.
authors.forename: F-Q
authors.initials: FQ
authors.lastname: Zhang
authors.affiliation: Peking Union Medical College Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, People's Republic of China.
authors.forename: X-R
authors.initials: XR
authors.lastname: Hou
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute, Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS), Beijing, People's Republic of China.
authors.forename: Q-F
authors.initials: QF
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Cancer Hospital and Institute, Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS), Beijing, People's Republic of China.
authors.forename: Y-X
authors.initials: YX
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000401:mortality* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D049451:Nomograms; D009669:Nose Neoplasms / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult