title: Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis.
abstract: Vaspin is an adipokine implicated in vascular inflammation and remodeling. We herein evaluated the clinical correlation of serum vaspin levels in systemic sclerosis (SSc). Consistent with previous reports, 12% of subjects exhibited serum vaspin levels over 10 ng/mL, likely due to genetic effects. Excluding these subjects, despite no difference between SSc and control subjects, serum vaspin levels were significantly decreased in SSc patients with digital ulcers compared with those without, suggesting the potential contribution of vaspin to digital ulcers of this disease.
authors.affiliation: Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Miura
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Saigusa
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashita
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ichimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Toyama
authors.forename: Zenshiro
authors.initials: Z
authors.lastname: Tamaki
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Tada
authors.forename: Makoto
authors.initials: M
authors.lastname: Sugaya
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kadono
mesh_terms: D000368:Aged; D005260:Female; D005385:Fingers; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000097:blood* / Q000150:complications; D015843:Serpins / Q000097:blood*; D012883:Skin Ulcer / Q000097:blood* / Q000150:complications; D014034:Toes
chemical_list: C507339:SERPINA12 protein, human; D015843:Serpins
keywords: digital ulcers; endothelial cells; systemic sclerosis; vascular smooth muscle cells; vaspin