title: Noninvasive test for tuberculosis detection among primates.
abstract: Traditional testing methods have limited epidemiologic studies of tuberculosis among free-living primates. PCR amplification of insertion element IS6110 of Mycobacterium tuberculosis from fecal samples was evaluated as a noninvasive screening test for tuberculosis in primates. Active tuberculosis was detected among inoculated macaques and naturally exposed chimpanzees, demonstrating the utility of this test.
authors.forename: Tiffany M
authors.initials: TM
authors.lastname: Wolf
authors.forename: Lawrence
authors.initials: L
authors.lastname: Mugisha
authors.forename: Fernanda Miyagaki
authors.initials: FM
authors.lastname: Shoyama
authors.forename: Melanie J
authors.initials: MJ
authors.lastname: O'Malley
authors.forename: JoAnne L
authors.initials: JL
authors.lastname: Flynn
authors.forename: Benon
authors.initials: B
authors.lastname: Asiimwe
authors.forename: Dominic A
authors.initials: DA
authors.lastname: Travis
authors.forename: Randall S
authors.initials: RS
authors.lastname: Singer
authors.forename: Srinand
authors.initials: S
authors.lastname: Sreevatsan
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000235:genetics; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D018419:Primate Diseases / Q000175:diagnosis* / Q000382:microbiology*; D014376:Tuberculosis / Q000662:veterinary*
chemical_list: D004269:DNA, Bacterial