title: FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.
abstract: Emerging evidence has suggested that misregulation of oncogenes and/or tumor suppressors has a crucial role in the development of lung carcinoma. The present study demonstrated that the expression levels of forkhead box O6 (FOXO6) were downregulated in lung cancer tissue samples, as compared with those in adjacent normal tissue. Overexpression of FOXO6 inhibited the proliferation of A549 human lung cancer cells, whereas knockdown of endogenous FOXO6 expression enhanced cell proliferation. Furthermore, ectopic FOXO6 expression induced the expression of ubiquitin-specific-processing protease 7 (USP7). As a result of this regulation, FOXO6 overexpression led to an elevation of p53 protein expression levels in A549 cells. In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development.
authors.affiliation: Department of Thoracic Tumor Surgery 2, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Hu
authors.affiliation: Department of Thoracic Tumor Surgery 2, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: Zhang
authors.affiliation: Department of Thoracic Tumor Surgery 2, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Department of Thoracic Tumor Surgery 2, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China.
authors.forename: Xi-Xi
authors.initials: XX
authors.lastname: Guo
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics*; D051858:Forkhead Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D043222:Ubiquitin Thiolesterase / Q000096:biosynthesis* / Q000235:genetics; D000076084:Ubiquitin-Specific Peptidase 7
chemical_list: C478770:FOXO6 protein, human; D051858:Forkhead Transcription Factors; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7