title: Autoimmune hepatitis-primary biliary cirrhosis concurrent with biliary stricture after liver transplantation.
abstract: Although the development of de novo autoimmune liver disease after liver transplantation (LT) has been described in both children and adults, autoimmune hepatitis (AIH)-primary biliary cirrhosis (PBC) overlap syndrome has rarely been seen in liver transplant recipients. Here, we report a 50-year-old man who underwent LT for decompensated liver disease secondary to alcoholic steatohepatitis. His liver function tests became markedly abnormal 8 years after LT. Standard autoimmune serological tests were positive for anti-nuclear and anti-mitochondrial antibodies, and a marked biochemical response was observed to a regimen consisting of prednisone and ursodeoxycholic acid added to maintain immunosuppressant tacrolimus. Liver biopsy showed moderate bile duct lesions and periportal lymphocytes infiltrating along with light fibrosis, which confirmed the diagnosis of AIH-PBC overlap syndrome. We believe that this may be a case of post-LT de novo AIH-PBC overlap syndrome; a novel type of autoimmune overlap syndrome.
authors.affiliation: Yong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Kang
authors.affiliation: Yong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
authors.forename: Xiao-Ye
authors.initials: XY
authors.lastname: Sun
authors.affiliation: Yong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
authors.forename: Yi-He
authors.initials: YH
authors.lastname: Liu
authors.affiliation: Yong-Zhen Kang, First Central clinic of Tianjin Medical University, Tianjin 300192, China.
authors.forename: Zhong-Yang
authors.initials: ZY
authors.lastname: Shen
mesh_terms: D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D002779:Cholestasis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005235:Fatty Liver, Alcoholic / Q000601:surgery*; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D007166:Immunosuppressive Agents; D014580:Ursodeoxycholic Acid; D011241:Prednisone; D016559:Tacrolimus
keywords: Autoimmune hepatitis; Autoimmune liver disease; Biliary stricture; Liver transplantation; Overlap syndrome; Primary biliary cirrhosis