title: Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study.
abstract: Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.
authors.affiliation: Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea.
authors.forename: Hyun-Hwan
authors.initials: HH
authors.lastname: Jeong
authors.affiliation: Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea.
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Sohn
keywords: KARE; gastritis; genome-wide association study; mutual information; relevance network; single-nucleotide polymorphism