title: Mechanistic analysis elucidating the relationship between Lys96 mutation in Mycobacterium tuberculosis pyrazinamidase enzyme and pyrazinamide susceptibility.
authors.forename: Chakshu
authors.initials: C
authors.lastname: Vats
authors.forename: Jaspreet
authors.initials: J
authors.lastname: Dhanjal
authors.forename: Sukriti
authors.initials: S
authors.lastname: Goyal
authors.forename: Ankita
authors.initials: A
authors.lastname: Gupta
authors.forename: Navneeta
authors.initials: N
authors.lastname: Bharadvaja
authors.forename: Abhinav
authors.initials: A
authors.lastname: Grover
mesh_terms: D000581:Amidohydrolases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000995:Antitubercular Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D008239:Lysine / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011718:Pyrazinamide / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D008024:Ligands; D011718:Pyrazinamide; D000581:Amidohydrolases; C487496:PncA protein, Mycobacterium tuberculosis; D008239:Lysine