title: Inflammatory Response to Sorbent Hemodialysis.
abstract: Inflammation is common and associated with morbidity and mortality in hemodialysis (HD) patients. Exposure to endotoxin contained in the dialysate may trigger inflammation. Dialysate volume is substantially reduced in sorbent HD compared with standard single-pass dialysis. In this prospective study (Clinicaltrials.gov, number: NCT00788905), we compared the inflammatory response to single-pass and sorbent HD. Patients receiving single-pass HD were studied during 1 week of sorbent HD (Allient system; Renal Solutions, Warrendale, PA) and 1 week of single-pass HD. Patients were dialyzed using high-flux polysulfone dialyzers. Midweek pre- and post-HD serum levels of high-sensitivity C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, interferon gamma, tumor necrosis factor alpha (TNF-α), and eotaxin were determined and their intradialytic change corrected for hemoconcentration during single-pass HD and sorbent HD compared by paired t-test. We enrolled 18 patients, nine completed the study. Although TNF-α decreased during both single-pass and sorbent HD (p < 0.001), none of the other biomarkers changed significantly during HD. We observed no difference between single-pass and sorbent HD. For the markers investigated in this study, there was no difference in the acute intradialytic inflammatory response to single-pass or sorbent HD.
authors.affiliation: From the *Renal Research Institute, New York, New York; †Mount Sinai Beth Israel, New York, New York; ‡Agarwal Nephrology and Hypertension PC, Columbus, Georgia; §Nephrology, Spitalzentrum, Biel, Switzerland; and ¶Erciyes Medical University, Nephrology, Kayseri, Turkey.
authors.forename: Laura
authors.initials: L
authors.lastname: Rosales
authors.forename: Stephan
authors.initials: S
authors.lastname: Thijssen
authors.forename: Anja
authors.initials: A
authors.lastname: Kruse
authors.forename: Murat Hairy
authors.initials: MH
authors.lastname: Sipahioglu
authors.forename: Padam
authors.initials: P
authors.lastname: Hirachan
authors.forename: Jochen G
authors.initials: JG
authors.lastname: Raimann
authors.forename: Viktoriya
authors.initials: V
authors.lastname: Kuntsevich
authors.forename: Mary
authors.initials: M
authors.lastname: Carter
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Levin
authors.forename: Peter
authors.initials: P
authors.lastname: Kotanko
mesh_terms: D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods*
chemical_list: D015415:Biomarkers; D016207:Cytokines