title: Copper-catalyzed hydroamination of alkynes with aliphatic amines: regioselective access to (1E,3E)-1,4-disubstituted-1,3-dienes.
abstract: Copper-catalyzed hydroamination of aromatic or heteroaromatic alkynes with cyclic secondary aliphatic amines undergoes generation of an enamine-type intermediate. The latter is transformed in situ via a coupling reaction with a second molecule of alkyne to afford regioselectively (1E,3E)-1,4-disubstituted-1,3-dienes with the formation of C-N, C-C, and C-H bonds.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Montpellier, Institut Charles Gerhardt, CNRS UMR 5253, AM2N, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 05, France.
authors.forename: Janet
authors.initials: J
authors.lastname: Bahri
authors.forename: Bassem
authors.initials: B
authors.lastname: Jamoussi
authors.forename: Arie
authors.initials: A
authors.lastname: van Der Lee
authors.forename: Marc
authors.initials: M
authors.lastname: Taillefer
authors.forename: Florian
authors.initials: F
authors.lastname: Monnier