title: The role of mitochondrial tRNA variants in female breast cancer.
abstract: Mitochondrial tRNA (Mt-tRNA) variants have been found to be involved in the carcinogenesis of breast cancer. These tRNAs, which played critical roles in mitochondrial protein synthesis, were important regulators in tumorigenesis. Distinguishing the polymorphisms or mutations in mt-tRNA genes was still puzzling for the clinicians and geneticists when confronted with the breast cancer. In this study, we performed a detailed analysis of recently reported mutations in mt-tRNA genes and further discussed the relationship between these variants and breast cancer.
authors.affiliation: a Department of Pharmacy and.
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Meng
authors.affiliation: b Department of Cardiology , Henan Provincial People's Hospital, Zhengzhou University People's Hospital , Zhengzhou , China.
authors.forename: Hua
authors.initials: H
authors.lastname: Meng
authors.affiliation: a Department of Pharmacy and.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: a Department of Pharmacy and.
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Qin
authors.affiliation: a Department of Pharmacy and.
authors.forename: Ning-Min
authors.initials: NM
authors.lastname: Zhao
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D012343:RNA, Transfer / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial; D012343:RNA, Transfer
keywords: Breast cancer; mitochondrial tRNA; mutations; polymorphisms; risk factor