title: Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection.
abstract: OBJECTIVE
  To evaluate new biomarkers such as YKL-40, preptin, and nitric oxide (NO) in patients with diabetes and to assess its relation to cardiorenal injury.
  
  
  METHODS
  The study included 62 patients with type 1 diabetes and 30 healthy volunteers. Blood sample was taken for assessment of glycosylated hemoglobin, lipid profile, YKL-40, preptin, and NO. Also, urine sample was taken for analysis of albumin/creatinine ratio. Echocardiography was also done.
  
  
  RESULTS
  NO was lower, whereas YKL-40, preptin, and albumin/creatinine ratio were significantly higher in patients with diabetes. NO had a significant negative correlation with LVEDD, LVESD, PWT, LV mass, YKL-40, preptin, and albumin/creatinine ratio. YKL-40 had a significant positive correlation with waist/height ratio, preptin and negative correlation with E/A ratio. Stepwise multiple regression revealed that E/A ratio is the only parameter related to YKL-40. On the contrary, NO and systolic blood pressure are related to preptin.
  
  
  CONCLUSIONS
  A significant reduction of NO and elevation of YKL-40 and preptin was found in patients with diabetes. A decrease in NO is associated with diastolic dysfunction, LV hypertrophy, and renal impairment, whereas YKL-40 is associated with diastolic dysfunction. An increase in preptin level was associated with hypertension.
authors.forename: Soha M
authors.initials: SM
authors.lastname: Abd El Dayem
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Battah
authors.forename: Amal
authors.initials: A
authors.lastname: El Shehaby
authors.forename: Nagwa
authors.initials: N
authors.lastname: Abd Allah
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D058065:Diabetic Cardiomyopathies / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D007335:Insulin-Like Growth Factor II; D037102:Lectins / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D010446:Peptide Fragments; C443100:preptin; D009569:Nitric Oxide; D007335:Insulin-Like Growth Factor II