title: The relationship between serum adiponectin and resistin levels, insulin resistance and colorectal adenomas.
abstract: OBJECTIVE
  The relationship between adipocytokines and the development of colorectal cancer is well-documented. Our aim was to assess the relationship among serum adiponectin and resistin levels, insulin resistance, and colorectal adenoma to evaluate whether these parameters can be used as biomarkers to predict the development of colorectal adenoma.
  
  
  METHODS
  This is a cross-sectional case-control study conducted in 32 patients with colorectal adenoma and 30 control subjects. Serum adiponectin and resistin levels, body mass index values, waist and hip circumferences and Homeostasis Model Assessment scores were measured.
  
  
  RESULTS
  Resistin levels were slightly higher and adiponectin was slightly lower in patients with colorectal adenoma compared with controls; however, the differences in both parameters failed to reach statistical significance. The body mass index values and waist circumference of the patient group were significantly higher than controls (p=0.003 and p=0.002, respectively). Fasting serum insulin levels and Homeostasis Model Assessment scores of patients with colorectal adenoma were significantly higher than those of controls (p=0.02 and p=0.02, respectively). There was no relation between the number of colorectal adenomas and serum adiponectin or resistin levels.
  
  
  CONCLUSIONS
  Our data indicate that obesity and insulin resistance may contribute to the development of colorectal adenoma and that serum adiponectin levels and insulin resistance may not have a substantial predictive value for colorectal adenoma.
authors.affiliation: Department of Gastroenterology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey. emelahishali@yahoo.com.
authors.forename: Nazlı
authors.initials: N
authors.lastname: Demir
authors.forename: Emel
authors.initials: E
authors.lastname: Ahıshalı
authors.forename: Can
authors.initials: C
authors.lastname: Dolapçıoğlu
authors.forename: Şerif
authors.initials: Ş
authors.lastname: Ercan
authors.forename: Asuman
authors.initials: A
authors.lastname: Orçun Kaptanağası
authors.forename: Reşat
authors.initials: R
authors.lastname: Dabak
authors.forename: Nihal
authors.initials: N
authors.lastname: Yücel
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sargın
authors.forename: Oya
authors.initials: O
authors.lastname: Uygur Bayramiçli
mesh_terms: D000236:Adenoma / Q000097:blood*; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood*; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D052243:Resistin / Q000097:blood*; D055105:Waist Circumference
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D007328:Insulin; C499624:RETN protein, human; D052243:Resistin