title: Ribosome-associated ncRNAs: an emerging class of translation regulators.
abstract: Accumulating recent evidence identified the ribosome as binding target for numerous small and long non-protein-coding RNAs (ncRNAs) in various organisms of all 3 domains of life. Therefore it appears that ribosome-associated ncRNAs (rancRNAs) are a prevalent, yet poorly understood class of cellular transcripts. Since rancRNAs are associated with the arguable most central enzyme of the cell it seems plausible to propose a role in translation control. Indeed first experimental evidence on small rancRNAs has been presented, linking ribosome association with fine-tuning the rate of protein biosynthesis in a stress-dependent manner.
authors.affiliation: a Department of Chemistry and Biochemistry ; University of Bern ; Bern , Switzerland.
authors.forename: Andreas
authors.initials: A
authors.lastname: Pircher
authors.forename: Jennifer
authors.initials: J
authors.lastname: Gebetsberger
authors.forename: Norbert
authors.initials: N
authors.lastname: Polacek
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D014176:Protein Biosynthesis; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*
chemical_list: D022661:RNA, Untranslated
keywords: lncRNA; non-coding RNA; ribosome; translation control