title: Ureaplasma parvum and Ureaplasma urealyticum detected with the same frequency among women with and without symptoms of urogenital tract infection.
abstract: There is mounting evidence stating that Ureaplasma urealyticum causes non-gonococcal urethritis in males, whereas Ureaplasma parvum does not seem to be of clinical significance. However, the clinical role of U. parvum and U. urealyticum in lower urogenital tract infections in females remains unclear. The aim of the study was to determine the frequency of U. parvum and U. urealyticum among 145 Ureaplasma spp. culture-positive women with symptoms of lower urogenital tract infection (n = 75) and those without (n = 70), and to determine possible associations between the detection of U. parvum and U. urealyticum with selected characteristics. Endocervical, urethral, and vaginal swabs, and first voided urine were obtained. Polymerase chain reaction (PCR) was performed to differentiate ureaplasmas. No significant association between the detection of U. parvum or U. urealyticum and symptom status was found. Significantly more women aged 25 years and younger were infected with U. urealyticum (23.4 %) compared to those aged above 25 years (9.2 %) [odds ratio (OR) 3.0 (1.1; 8.1); p = 0.03] and significantly less women aged 25 years and younger (83.5 %) were infected with U. parvum compared to those aged above 25 years (95.5 %) [OR 0.2 (0.1; 0.9); p = 0.03]. The detection of Chlamydia trachomatis was significantly associated to both U. parvum and U. urealyticum (p = 0.021), and to U. parvum alone with borderline significance (p = 0.063). Although neither U. parvum nor U. urealyticum seem to cause symptoms in females, their role in the female urogenital tract remains unknown, taking into account their ubiquity, possible augmentation of the urogenital microenvironment, and ascending capability to the sterile upper reproductive tract.
authors.affiliation: University Medical Centre Maribor, Ljubljanska 5, 2000, Maribor, Slovenia.
authors.forename: M
authors.initials: M
authors.lastname: Marovt
authors.forename: D
authors.initials: D
authors.lastname: Keše
authors.forename: T
authors.initials: T
authors.lastname: Kotar
authors.forename: N
authors.initials: N
authors.lastname: Kmet
authors.forename: J
authors.initials: J
authors.lastname: Miljković
authors.forename: B
authors.initials: B
authors.lastname: Šoba
authors.forename: M
authors.initials: M
authors.lastname: Matičič
mesh_terms: D000328:Adult; D000367:Age Factors; D002584:Cervix Uteri / Q000382:microbiology; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D005260:Female; D052776:Female Urogenital Diseases / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D014509:Ureaplasma / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D016990:Ureaplasma urealyticum / Q000302:isolation & purification*; D014521:Urethra / Q000382:microbiology; D014556:Urine / Q000382:microbiology; D014621:Vagina / Q000382:microbiology; D055815:Young Adult