title: Bifunctional magnetic-fluorescent nanoparticles: synthesis, characterization, and cell imaging.
abstract: A new type of bifunctional magnetic-fluorescent Fe3O4@SiO2-PDI-PAA/Ca(2+) nanoparticles has been prepared by coating PDI-cored star polymers (PDI-PAA) onto the surface of Fe3O4@SiO2 core-shell nanostructures. The morphology and properties of the composite nanoparticles are investigated by transmission electron microscopy, ultraviolet-visible spectrometry, fluorescence spectrometry, and vibrating sample magnetometry. The composite nanoparticles display a strong red emission and superparamagnetic behavior at room temperature. The cell viability and uptake assays reveal good biocompatibility of these hybrid nanoparticles. Hence, the composite nanoparticles are of potential to be further explored as therapeutic vector in biomedical field.
authors.affiliation: State Key Laboratory of Chemical Resource Engineering, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology , 100029 Beijing, China.
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Shusen
authors.initials: S
authors.lastname: You
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Gao
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.forename: Wantai
authors.initials: W
authors.lastname: Yang
authors.forename: Meizhen
authors.initials: M
authors.lastname: Yin
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008856:Microscopy, Fluorescence; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013696:Temperature
chemical_list: D058185:Magnetite Nanoparticles; D011108:Polymers; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide
keywords: bioimaging; fluorescence; magnetic nanoparticles; star polymer