title: Short-term effect of gastric resection on circulating levels of ghrelin, peptide YY3-36 and obestatin in patients with early gastric cancer.
abstract: The short-term responses of gut hormones and the compensative interaction during a one-week period after subtotal gastrectomy in early gastric cancer (EGC) patients were assessed. Previous studies have reported gut hormonal changes after Roux-en-Y gastric bypass surgery. Blood samples were collected from 40 patients with EGC preoperatively, at 1 h after gastric resection, and on postoperative day (POD) 1, 3, and 7. Levels of active ghrelin, total ghrelin, obestatin, and PYY3-36 were measured. Total ghrelin level rapidly reached a nadir of 69.1%, while active ghrelin level had increased to 135.5% at 1 h after resection. Then, both returned to preoperative level. On the contrary, active/total ghrelin reached its nadir quickly at 1 h after resection and had returned to the preoperative level by POD 3. The nadir PYY3-36 level was 71.4% on POD 1, followed by a gradual recovery, and had increased to 116.5% by POD 7. The same pattern was observed for obestatin. Active ghrelin/obestatin showed an increase on POD 1 while total ghrelin/obestatin showed a decrease on POD 3. Then, both returned to preoperative level. These results suggest that a rapid interactive compensatory mechanism of gut hormones does exist in the remnant gastrointestinal tract after abrupt changes in the production reservoir in nonobese people.
authors.affiliation: Department of Surgery, Pusan National University School of Medicine, Gyeongsangnam-do, South Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Jeon
authors.affiliation: Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, Gyeongsangnam-do, South Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Pusan National University Hospital, Busan, South Korea.
authors.forename: H H
authors.initials: HH
authors.lastname: Kim
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, South Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Cho
authors.affiliation: Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, South Korea.
authors.forename: A R
authors.initials: AR
authors.lastname: Cho
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D019894:Peptide YY / Q000097:blood*; D011184:Postoperative Period; D057234:Preoperative Period; D013274:Stomach Neoplasms / Q000601:surgery*; D013997:Time Factors
chemical_list: D054439:Ghrelin; D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)