title: Prognostic significance of tumour stroma ratio in inflammatory breast cancer.
abstract: Tumour stroma ratio (TSR) is emerging as an important prognostic indicator in cancer. We have previously shown TSR to be prognostic in oestrogen receptor positive breast cancer. Its role in inflammatory breast cancer, a rare but aggressive form of breast cancer, has not been identified. Here we aimed to determine the prognostic significance of TSR in a cohort of patients with inflammatory breast carcinoma. TSR was measured by point counting virtual H&E stained tissue sections in 45 inflammatory breast cancer cases. The whole tumour area was sampled. Optimum cut-offs to distinguish high and low TSR was determined by log-rank test. The relationship of TSR to overall survival and disease-free survival (DFS) was analysed alongside multivariate analysis. The optimal cut-offs between high and low TSR were determined to be 31% for OS and 46% for DFS. There was no significant difference in OS (p = 0.53) nor DFS (p = 0.66) between high and low TSR groups. Multivariate analysis did not demonstrate any new trends, within the limits of a small data sample. A significant correlation was found between pathological response to neoadjuvant chemotherapy and survival (p = 0.008). There is no evidence that TSR has prognostic significance in inflammatory breast cancer. When compared with published data in non-inflammatory breast carcinoma, this supports the view that differences in stromal biology exist between tumour types and highlights the importance of considering this when interpreting the prognostic value of TSR. However, these findings must be interpreted in the light of the small sample size.
authors.affiliation: St James's University Hospital, Leeds, LS9 7TF UK.
authors.forename: Candice L
authors.initials: CL
authors.lastname: Downey
authors.affiliation: Leeds Institute of Cancer & Pathology, University of Leeds, St James's University Hospital, Leeds, LS9 7TF UK.
authors.forename: Helene H
authors.initials: HH
authors.lastname: Thygesen
authors.affiliation: St James's University Hospital, Leeds, LS9 7TF UK.
authors.forename: Nisha
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham and University of Birmingham, Birmingham, B15 2TW UK.
authors.forename: Abeer M
authors.initials: AM
authors.lastname: Shaaban
keywords: Breast cancer; Inflammatory; Prognosis; Stroma; Tumour-stroma ratio