title: (Aminophosphane)gold(I) and silver(I) complexes as antibacterial agents.
abstract: This manuscript describes the synthesis of new Au(I) and Ag(I) complexes with aminophosphane ligands and a study of their antibacterial activity against Gram-negative Salmonella enterica serovar typhimurium and Escherichia coli and Gram-positive Listeria monocytogenes and Staphylococcus aureus. The bactericidal assays revealed the effectiveness of these compounds on paradigm Gram-negative and Gram-positive pathogens, showing a moderate antimicrobial activity, comparable with the antibiotics of reference, for all gold(I) complexes and the silver(I) complexes without coordinated PPh3 groups. For those complexes that were found to show inhibitory activity, serial dilutions in liquid broth method were performed for determination of MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration).
authors.affiliation: Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Ortego
authors.affiliation: Grupo de Genética de Micobacterias, Departamento de Microbiología, Medicina Preventiva y Salud Pública, Facultad de Medicina, Universidad de Zaragoza, E-50009 Zaragoza, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, E-28029 Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Gonzalo-Asensio
authors.affiliation: Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Laguna
authors.affiliation: Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain. Electronic address: dvilla@unizar.es.
authors.forename: M Dolores
authors.initials: MD
authors.lastname: Villacampa
authors.affiliation: Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain. Electronic address: gimeno@unizar.es.
authors.forename: M Concepción
authors.initials: MC
authors.lastname: Gimeno
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D050607:Organogold Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D018030:Silver Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D050607:Organogold Compounds; D009943:Organophosphorus Compounds; D018030:Silver Compounds; D014230:Triazoles
keywords: Aminophosphine ligands; Antibacterial activity; Gold(I); Gram-negative; Gram-positive; Silver(I)