title: eIF4E as a control target for viruses.
abstract: Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves.
authors.affiliation: Public Health Institute, University of Veracruz, Veracruz 91190, Mexico. hmontero@uv.mx.
authors.forename: Hilda
authors.initials: H
authors.lastname: Montero
authors.affiliation: Public Health Institute, University of Veracruz, Veracruz 91190, Mexico. garciaromanrebeca@gmail.com.
authors.forename: Rebeca
authors.initials: R
authors.lastname: García-Román
authors.affiliation: Preparative Procedures and Access to Proteomic Services Unit, Institute of Biomedical Research, National Autonomous University of Mexico. Distrito Federal 04510, Mexico. sivonnemor@biomedicas.unam.mx.
authors.forename: Silvia I
authors.initials: SI
authors.lastname: Mora
mesh_terms: D002352:Carrier Proteins; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism*; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions; D011485:Protein Binding; D014176:Protein Biosynthesis; D014764:Viral Proteins / Q000378:metabolism; D018406:Virus Physiological Phenomena
chemical_list: D002352:Carrier Proteins; D039561:Eukaryotic Initiation Factor-4E; D014764:Viral Proteins