title: Accurate quantitative measurements of brachial artery cross-sectional vascular area and vascular volume elastic modulus using automated oscillometric measurements: comparison with brachial artery ultrasound.
abstract: Increasing vascular diameter and attenuated vascular elasticity may be reliable markers for atherosclerotic risk assessment. However, previous measurements have been complex, operator-dependent or invasive. Recently, we developed a new automated oscillometric method to measure a brachial artery's estimated area (eA) and volume elastic modulus (V(E)). The aim of this study was to investigate the reliability of new automated oscillometric measurement of eA and V(E). Rest eA and V(E) were measured using the recently developed automated detector with the oscillometric method. eA was estimated using pressure/volume curves and V(E) was defined as follows (V(E)=Δ pressure/ (100 × Δ area/area) mm Hg/%). Sixteen volunteers (age 35.2±13.1 years) underwent the oscillometric measurements and brachial ultrasound at rest and under nitroglycerin (NTG) administration. Oscillometric measurement was performed twice on different days. The rest eA correlated with ultrasound-measured brachial artery area (r=0.77, P<0.001). Rest eA and VE measurement showed good reproducibility (eA: intraclass correlation coefficient (ICC)=0.88, V(E): ICC=0.78). Under NTG stress, eA was significantly increased (12.3±3.0 vs. 17.1±4.6 mm(2), P<0.001), and this was similar to the case with ultrasound evaluation (4.46±0.72 vs. 4.73±0.75 mm, P<0.001). V(E) was also decreased (0.81±0.16 vs. 0.65±0.11 mm Hg/%, P<0.001) after NTG. Cross-sectional vascular area calculated using this automated oscillometric measurement correlated with ultrasound measurement and showed good reproducibility. Therefore, this is a reliable approach and this modality may have practical application to automatically assess muscular artery diameter and elasticity in clinical or epidemiological settings.
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Tomiyama
authors.affiliation: Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.affiliation: Department of Laboratory Medicine, Asahikawa Medical University, Hokkaido, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujii
authors.affiliation: Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Noriki
authors.initials: N
authors.lastname: Ochi
authors.affiliation: Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University Hospital, Hokkaido, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Mutumi
authors.initials: M
authors.lastname: Nishida
authors.affiliation: Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Aziki
authors.affiliation: Division of Clinical Laboratory and Transfusion Medicine, Hokkaido University Hospital, Hokkaido, Japan.
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Horie
authors.affiliation: Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
authors.affiliation: Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology; D019412:Anatomy, Cross-Sectional; D001916:Brachial Artery / Q000033:anatomy & histology* / Q000000981:diagnostic imaging* / Q000187:drug effects; D055119:Elastic Modulus / Q000187:drug effects; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D009991:Oscillometry / Q000379:methods*; D011312:Pressure; D015203:Reproducibility of Results; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin