title: Magnetic nanoparticle-supported lipid bilayers for drug delivery.
abstract: Magnetic nanoparticle-supported lipid bilayers (SLBs) constructed around core-shell Fe3O4-SiO2 nanoparticles (SNPs) were prepared and evaluated as potential drug carriers. We describe how an oxime ether lipid can be mixed with SNPs to produce lipid-particle assemblies with highly positive ζ potential. To demonstrate the potential of the resultant cationic SLBs, the particles were loaded with either the anticancer drug doxorubicin or an amphiphilic analogue, prepared to facilitate integration into the supported lipid bilayer, and then examined in studies against MCF-7 breast cancer cells. The assemblies were rapidly internalized and exhibited higher toxicity than treatments with doxorubicin alone. The magnetic SLBs were also shown to increase the efficacy of unmodified doxorubicin.
authors.affiliation: †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Mattingly
authors.affiliation: †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
authors.forename: Martin G
authors.initials: MG
authors.lastname: O'Toole
authors.affiliation: †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
authors.forename: Kurtis T
authors.initials: KT
authors.lastname: James
authors.affiliation: †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Clark
authors.affiliation: †Department of Chemistry, ‡Department of Biomedical Engineering, J.B. Speed School of Engineering, and §School of Medicine, University of Louisville, Louisville, Kentucky 40292, United States.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Nantz
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry*; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008051:Lipid Bilayers; D058185:Magnetite Nanoparticles; D004317:Doxorubicin