title: Self-assessment of color categories and its relationship with HLA profiling in Brazilian bone marrow donors.
abstract: The Brazil Ministry of Health maintains a Registry of Bone Marrow Donors that corresponds to approximately 12% of the Bone Marrow Donors Worldwide registry. This registry contains information on ethnicity (by self-assessment of color) and HLA-A, -B, and -DRB1 type. The self-assessment of color tool has been extensively used for admixed population characterization. In this context, Brazil represents a highly admixed population, resulting from 5 centuries of colonization and interbreeding, mainly, but not exclusively, among Native Americans, Europeans, and Africans. Here we evaluated self-assessed skin color and HLA genetic information from 71,291 bone marrow donors of southern Brazil to verify how likely is the HLA profiling correspondence within and between self-assessed color groups. We found that HLA itself was a better ancestry indicator than was self-assessed color. Therefore, self-assessment of color in highly admixed populations, such as that of Brazil, is not indicative of higher correspondence in the HLA profiles within skin color groups.
authors.affiliation: Instituto Nacional de Genetica Medica Populacional, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Juliano
authors.initials: J
authors.lastname: Boquett
authors.affiliation: Instituto Nacional de Genetica Medica Populacional, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Lavínia
authors.initials: L
authors.lastname: Schüler-Faccini
authors.affiliation: Department of Immunology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Jobim
authors.affiliation: Department of Immunology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Jobim
authors.affiliation: Instituto Nacional de Genetica Medica Populacional, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Nelson Jurandi Rosa
authors.initials: NJ
authors.lastname: Fagundes
authors.affiliation: Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: hunemeier@gmail.com.
authors.forename: Tábita
authors.initials: T
authors.lastname: Hünemeier
mesh_terms: D000483:Alleles; D044383:Black People / Q000235:genetics; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data; D001938:Brazil; D015870:Gene Expression; D005787:Gene Frequency; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D012042:Registries; D012647:Self-Assessment; D014019:Tissue Donors; D044465:White People / Q000235:genetics
chemical_list: D006680:HLA Antigens
keywords: Admixed population; Bone marrow donors; HLA; Self-assessed color