title: Does ovarian reserve predict egg quality in unstimulated therapeutic donor insemination cycles?
abstract: OBJECTIVE
  To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  University-affiliated regional fertility clinic.
  
  
  METHODS
  Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013.
  
  
  METHODS
  Unstimulated therapeutic donor insemination.
  
  
  METHODS
  Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality.
  
  
  RESULTS
  The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count.
  
  
  CONCLUSIONS
  AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.
authors.affiliation: Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: ripley.mike@gmail.com.
authors.forename: Mike
authors.initials: M
authors.lastname: Ripley
authors.affiliation: Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Lanes
authors.affiliation: Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Léveillé
authors.affiliation: Ottawa Fertility Centre, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Doron
authors.initials: D
authors.lastname: Shmorgun
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D053713:Azoospermia / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous; D008297:Male; D008423:Maternal Age; D009864:Ontario; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D010050:Ovarian Function Tests; D065851:Ovarian Reserve; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography
keywords: Diminished ovarian reserve; antral follicle count; miscarriage rate; pregnancy rate; therapeutic donor insemination