title: [Current Topics on Vitamin D. Combined therapy of anti-resorptive drug and active vitamin D].
abstract: Combination therapy of oral bisphosphonate and vitamin D analogue showed superior anti-osteoporotic effect compare to bisphosphonate mono-therapy for post menopausal, male and glucocorticoid-induced osteoporosis. Furthermore, the degree of success of oral bisphosphonate therapy for osteoporotic patients should depend on the their vitamin D status. It is thought that we have to evaluate severity of osteoporosis and vitamin D status before started therapy. The combination therapy of these drugs will be more efficient for relatively patients with severe osteoporotic patients and with low vitamin D status.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism / Q000627:therapeutic use; D004164:Diphosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D014807:Vitamin D / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D014807:Vitamin D; D002118:Calcium