title: A smart DNA-gold nanoparticle probe for detecting single-base changes on the platform of a quartz crystal microbalance.
abstract: A design of DNA-gold nanoparticle probe-fueled DNA strand displacements for detecting single-base changes on the platform of a quartz crystal microbalance with random sequences was developed. After optimizing and testing the detection system, it has been successfully applied to detect mutation of a realistic sequence associated with human cancer, thereby indicating that this method has potential applicability in general.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China. hjliang@ustc.edu.cn.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Shiyan
authors.initials: S
authors.lastname: Xiao
authors.forename: Dongbao
authors.initials: D
authors.lastname: Yao
authors.forename: Michael Hon-Wah
authors.initials: MH
authors.lastname: Lam
authors.forename: Haojun
authors.initials: H
authors.lastname: Liang
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000737:chemistry*; D004252:DNA Mutational Analysis; D015342:DNA Probes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D009154:Mutation; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D015342:DNA Probes; D006046:Gold; D004247:DNA