title: Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells.
abstract: Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions.
authors.affiliation: Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. ijdae@kangwon.ac.kr.
authors.forename: Jung Dae
authors.initials: JD
authors.lastname: Lim
authors.affiliation: College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. lsr1113@inje.ac.kr.
authors.forename: Sung Ryul
authors.initials: SR
authors.lastname: Lee
authors.affiliation: Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. noddle1@hanmail.net.
authors.forename: Taeseong
authors.initials: T
authors.lastname: Kim
authors.affiliation: Department of Life Science, Gachon University, Seongnam 461-701, Korea. white7068@daum.net.
authors.forename: Seon-A
authors.initials: SA
authors.lastname: Jang
authors.affiliation: Department of Life Science, Gachon University, Seongnam 461-701, Korea. sckang73@gachon.ac.kr.
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.affiliation: Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea. dewykoo@gmail.com.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Koo
authors.affiliation: Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea. essohn@kisti.re.kr.
authors.forename: Eunsoo
authors.initials: E
authors.lastname: Sohn
authors.affiliation: The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea. jpbak77@gmail.com.
authors.forename: Jong Phil
authors.initials: JP
authors.lastname: Bak
authors.affiliation: Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea. seungnk@kangwon.ac.kr.
authors.forename: Seung
authors.initials: S
authors.lastname: Namkoong
authors.affiliation: College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. estrus74@gmail.com.
authors.forename: Hyoung Kyu
authors.initials: HK
authors.lastname: Kim
authors.affiliation: College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. microvirus@hanmail.net.
authors.forename: In Sung
authors.initials: IS
authors.lastname: Song
authors.affiliation: College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. phykimnr@inje.ac.kr.
authors.forename: Nari
authors.initials: N
authors.lastname: Kim
authors.affiliation: Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea. ehson@kangwon.ac.kr.
authors.forename: Eun-Hwa
authors.initials: EH
authors.lastname: Sohn
authors.affiliation: College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea. phyhanj@inje.ac.kr.
authors.forename: Jin
authors.initials: J
authors.lastname: Han
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002460:Cell Line; D051546:Cyclooxygenase 2 / Q000378:metabolism; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D044645:Fucus / Q000737:chemistry*; D051547:Heme Oxygenase-1 / Q000096:biosynthesis; D056945:Hep G2 Cells; D006519:Hepatitis, Alcoholic / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D009929:Organ Size / Q000187:drug effects; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D018836:Inflammation Mediators; D011134:Polysaccharides; C508961:Tgfb1 protein, mouse; D053773:Transforming Growth Factor beta1; D009569:Nitric Oxide; C007789:fucoidan; D051547:Heme Oxygenase-1; D051546:Cyclooxygenase 2; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase