title: Synchronous gastric and ampullary adenocarcinomas in a hairy cell leukemia patient treated with pentostatin eight years prior.
abstract: Hairy cell leukemia patients are at increased risk for second malignancies, including both solid and lymphoid neoplasms. Along with other factors, multiple immune defects present in hairy cell leukemia likely contribute to subsequent carcinogenesis. We report herein a case of synchronous high-grade gastric and ampullary adenocarcinomas in a patient with a history of hairy cell leukemia treated eight years prior with pentostatin. We include a review of immune alterations induced by both hairy cell leukemia and its therapies, and link them with the occurrence of second cancers in these patients.
authors.affiliation: Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA senatore@uchc.edu.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Senatore
authors.affiliation: Lucy Curci Cancer Center, Eisenhower Medical Center/University of Southern California, Rancho Mirage, CA, USA.
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D003138:Common Bile Duct Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000175:diagnosis; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis; D015649:Pentostatin / Q000008:administration & dosage / Q000009:adverse effects*; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D015649:Pentostatin
keywords: Hairy cell leukemia; ampullary adenocarcinoma; gastric adenocarcinoma; second cancers