title: Treatment of invasive silent somatotroph pituitary adenoma with temozolomide. Report of a case and review of the literature.
abstract: Improved imaging techniques have contributed to increased diagnosis of pituitary tumors. These tumor types can be microadenomas or macroadenomas and can either be functional or non-functional. Atypical or aggressive pituitary adenomas are tumors that rapidly increase in size and may invade into the suprasellar or parasellar regions. They are characterized by a Ki-67 nuclear labeling index greater than 10 %. Management of these tumors is difficult, and many recur after surgery. Temozolomide, a second generation alkylating agent, has been showing promising results in the treatment of these tumors. The patient was a 39-year-old male diagnosed with an invasive silent somatotroph pituitary macroadenoma treated with temozolomide after surgery. We present the case along with the review of the literature of the therapeutic effects of temozolomide in somatotroph macroadenomas.
authors.affiliation: Department of Surgery, Division of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ali A
authors.initials: AA
authors.lastname: Ghazi
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
authors.forename: Alireza
authors.initials: A
authors.lastname: Amirbaigloo
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.forename: Hussein
authors.initials: H
authors.lastname: Fathalla
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
mesh_terms: D000236:Adenoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D058070:Asymptomatic Diseases / Q000628:therapy; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide