title: Inguinal hernia repair in premature infants: more questions than answers.
abstract: This review shows that there are many single institution studies reviewing outcomes of premature infants with IH. However, the numbers of patients in these studies are often small and most studies were retrospective, therefore, these studies were subject to the limitations inherent to observational studies for identifying best treatment methods. Nevertheless, the studies show that risks are high in this population and that outcomes may vary with the timing of repair. There have been calls for multicentre randomised trials comparing early versus later IH repair from all over the world and for a very long time. Yet, despite the frequency of IH repair in premature infants, this issue remains unstudied in a high-quality manner. A large, multicentre randomised trial is currently underway to address the effect of timing on the short-term and long-term safety and efficacy of IH repair in this population so that we may be able to deliver safe surgical care to this vulnerable population.
authors.affiliation: Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Eileen M
authors.identifier: http://orcid.org/0000-0003-3080-0570
authors.initials: EM
authors.lastname: Duggan
authors.affiliation: Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Vikram P
authors.initials: VP
authors.lastname: Patel
authors.affiliation: Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Martin L
authors.initials: ML
authors.lastname: Blakely
mesh_terms: D001049:Apnea / Q000209:etiology / Q000517:prevention & control; D001919:Bradycardia / Q000209:etiology / Q000517:prevention & control; D006552:Hernia, Inguinal / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D020379:Risk Adjustment; D061665:Time-to-Treatment
keywords: Anaesthetics; Clinical Procedures; Congenital Abnorm; Evidence Based Medicine; Neonatology