title: Orange-brown chromonychia and Kawasaki disease: a possible novel association?
abstract: A 4-year-old girl with clinical and laboratory signs of Kawasaki disease (KD) was hospitalized and given intravenous immunoglobulin plus aspirin therapy, with rapid defervescence and clinical improvement, and was discharged 48 hours after admission. At the time of her follow-up echocardiography on day 14, orange-brown pigmentation of the nail beds was noticed and confirmed with dermoscopy. No clear association between KD and orange-brown chromonychia has been demonstrated, although reports and case series suggest a possible link between these two entities. We suggest that this particular finding might be encompassed in late (subacute) changes of extremities as part of KD diagnostic criteria.
authors.affiliation: Department of Pediatrics, Ospedale Dell'Angelo, Mestre, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Tessarotto
authors.affiliation: Department of Woman and Child Health, Medical School, University of Padua, Padova, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Rubin
authors.affiliation: Department of Woman and Child Health, Medical School, University of Padua, Padova, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bonadies
authors.affiliation: Department of Woman and Child Health, Medical School, University of Padua, Padova, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Valerio
authors.affiliation: Department of Pediatrics, Ospedale Dell'Angelo, Mestre, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Cutrone
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004452:Echocardiography; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000188:drug therapy*; D009260:Nail Diseases / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D016756:Immunoglobulins, Intravenous; D001241:Aspirin