title: Bioactivity and chemical composition of the essential oil from the leaves of Guatteria australis A.St.-Hil.
abstract: Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC-MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.
authors.affiliation: a Departamento de Biologia Vegetal , Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP) , 13083-970 Campinas , SP , Brazil.
authors.forename: Carlos Alberto Theodoro
authors.initials: CA
authors.lastname: Siqueira
authors.forename: Alessandra Freitas
authors.initials: AF
authors.lastname: Serain
authors.forename: Aislan Cristina Rheder Fagundes
authors.initials: AC
authors.lastname: Pascoal
authors.forename: Nathalia Luiza
authors.initials: NL
authors.lastname: Andreazza
authors.forename: Caroline Caramano
authors.initials: CC
authors.lastname: de Lourenço
authors.forename: Ana Lúcia T Góis
authors.initials: AL
authors.lastname: Ruiz
authors.forename: João Ernesto
authors.initials: JE
authors.lastname: de Carvalho
authors.forename: Ana Cláudia Oliveira
authors.initials: AC
authors.lastname: de Souza
authors.forename: Juliana Tonini
authors.initials: JT
authors.lastname: Mesquita
authors.forename: Andre Gustavo
authors.initials: AG
authors.lastname: Tempone
authors.forename: Marcos José
authors.initials: MJ
authors.lastname: Salvador
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000302:isolation & purification; D031043:Guatteria / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D000981:Antiprotozoal Agents; D009822:Oils, Volatile; D010938:Plant Oils; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C024714:caryophyllene; C027259:germacrene D
keywords: Annonaceae; Guatteria australis; bioactivity; essential oil