title: Predictors of urinary continence recovery after modified radical prostatectomy for clinically high-risk prostate cancer.
abstract: OBJECTIVE
  To retrospectively determine predictors of urinary continence (UC) recovery in clinically high-risk prostate cancer (PCa) patients treated with modified radical prostatectomy (RP).
  
  
  METHODS
  A total of 184 patients with clinically high-risk PCa who underwent modified RP in a single Chinese center were retrospectively reviewed. Pelvic floor muscle training with biofeedback was routinely performed after catheter removal. UC was defined as wearing 0 or 1 protective pad daily. Univariate and multivariate Cox regression analyses were performed to determine the predictors of UC recovery.
  
  
  RESULTS
  The median age at surgery was 69.5 years (range 48-82), and the median follow-up duration was 40 months (range 12-111). Only 40 patients (21.7%) received a nerve-sparing procedure. For patients with restored UC, the median time to continence was 1 month (range 1-24). UC recovery at 1 month, 6 months, 12 months and the most recent follow-up was observed in 99 (53.8%), 158 (85.9%), 171 (92.9%) and 174 (94.6%) patients, respectively. Multivariate Cox regression analysis showed that patient age &lt; 70 years (hazard ratio 1.684, P = .003) and smaller prostate volume (hazard ratio 0.989, P = .036), but not the surgical approach or treatment with a nerve-sparing procedure, independently predicted UC recovery.
  
  
  CONCLUSIONS
  Age &lt; 70 years and smaller prostate volume were independent predictors of UC recovery in clinically high-risk PCa patients. The adverse factors of high-risk disease were not significantly associated with UC recovery. These results may help surgeons preoperatively counsel patients regarding expected UC outcomes following RP.&nbsp;
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Hou
authors.forename: Yun
authors.initials: Y
authors.lastname: Luo
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Di
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Pang
authors.forename: Jie
authors.initials: J
authors.lastname: Si-Tu
authors.affiliation: Department of Urology, The Third Affiliated Hospital, Sun Yat-sen University, Tianhe Road 600, Guangzhou, 510630, China. urogx@hotmail.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D041342:Absorbent Pads; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005081:Exercise Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D017773:Pelvic Floor; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy / Q000009:adverse effects* / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology / Q000601:surgery*; D020127:Recovery of Function; D012189:Retrospective Studies; D014549:Urinary Incontinence / Q000209:etiology / Q000628:therapy*