title: Iridium-catalyzed direct synthesis of tryptamine derivatives from indoles: exploiting n-protected β-amino alcohols as alkylating agents.
abstract: The selective C3-alkylation of indoles with N-protected ethanolamines involving the "borrowing hydrogen" strategy is described. This method provides convenient and sustainable access to several tryptamine derivatives.
authors.affiliation: Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bartolucci
authors.affiliation: Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Mari
authors.affiliation: Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
authors.forename: Annalida
authors.initials: A
authors.lastname: Bedini
authors.affiliation: Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piersanti
authors.affiliation: Department of Biomolecular Sciences, University of Urbino "Carlo Bo", Piazza del Rinascimento 6, 61029 Urbino (PU), Italy.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Spadoni
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D014363:Tryptamines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D000605:Amino Alcohols; D007211:Indoles; D009942:Organometallic Compounds; D014363:Tryptamines; C030820:tryptamine; D007495:Iridium