title: Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial.
abstract: BACKGROUND
  Whether a coronary artery calcium (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department patients with acute chest pain remains unsettled. We sought to determine the value of CAC scan in patients with acute chest pain undergoing CCTA.
  
  
  RESULTS
  In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department patients with symptoms suggesting acute coronary syndrome (ACS). In this prespecified subanalysis of 473 patients (54±8 years, 53% men) who underwent both CAC scanning and CCTA, the ACS rate was 8%. Overall, 53% of patients had CAC=0 of whom 2 (0.8%) developed ACS, whereas 7% had CAC>400 with 49% whom developed ACS. C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC≥22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC≥22 (P≥0.09). Mean radiation dose from CAC acquisition was 1.4±0.7 mSv. Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable.
  
  
  CONCLUSIONS
  In emergency department patients with acute chest pain, CAC score does not provide incremental value beyond CCTA for ACS diagnosis. CAC=0 does not exclude ACS, nor a high CAC score preclude interpretation of CCTA in most patients. Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required.
  
  
  BACKGROUND
  http://www.clinicaltrials.gov. Unique identifier: NCT01084239.
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Amit
authors.initials: A
authors.lastname: Pursnani
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Eric T
authors.initials: ET
authors.lastname: Chou
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Pearl
authors.initials: P
authors.lastname: Zakroysky
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Roderick C
authors.initials: RC
authors.lastname: Deaño
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Wilfred S
authors.initials: WS
authors.lastname: Mamuya
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Woodard
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: John T
authors.initials: JT
authors.lastname: Nagurney
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Jerome L
authors.initials: JL
authors.lastname: Fleg
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Hang
authors.initials: H
authors.lastname: Lee
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: David
authors.initials: D
authors.lastname: Schoenfeld
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: James E
authors.initials: JE
authors.lastname: Udelson
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
authors.affiliation: From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.). qat9001@med.cornell.edu.
authors.forename: Quynh A
authors.initials: QA
authors.lastname: Truong
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging*; D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging*; D017023:Coronary Angiography / Q000379:methods / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D012720:Severity of Illness Index; D014481:United States; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
keywords: acute coronary syndrome; hospital emergency service; multidetector-row computed tomography