title: [Information theory of ageing: studying the effect of bone marrow transplantation on the life span of mice].
abstract: In this paper the method of life span extension of multicellular organisms (human) using the reservation of stem cells followed by autotransplantation has been proposed. As the efficiency of this method results from the information theory of ageing, it is important to verify it experimentally testing the basic concepts of the theory. Taking it into consideration, the experiment on the bone marrow transplantation to old mice from young closely-related donors of the inbred line was carried out. It has been shown, that transplanted animals exhibited a survival advantage, a mean life span increased by 34% as compared to the control. This result not only demonstrates the efficiency of the proposed method for life span extension of multicellular organisms, but also confirms the basis of the information theory of ageing.
authors.forename: A V
authors.initials: AV
authors.lastname: Karnaukhov
authors.forename: E V
authors.initials: EV
authors.lastname: Karnaukhova
authors.forename: L A
authors.initials: LA
authors.lastname: Sergievich
authors.forename: N A
authors.initials: NA
authors.lastname: Karnaukhova
authors.forename: N A
authors.initials: NA
authors.lastname: Karnaukhova
authors.forename: E V
authors.initials: EV
authors.lastname: Bogdanenko
authors.forename: A A
authors.initials: AA
authors.lastname: Smirnov
authors.forename: I A
authors.initials: IA
authors.lastname: Manokhina
authors.forename: V N
authors.initials: VN
authors.lastname: Karnaukhov
mesh_terms: D064591:Allografts; D000818:Animals; D016026:Bone Marrow Transplantation; D008136:Longevity; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological