title: Antenatal imaging of anomalies of the corpus callosum: a decade of experience.
abstract: OBJECTIVE
  To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (FMRI) over the past decade in the diagnosis of anomalies of the corpus callosum in a tertiary referral centre.
  
  
  METHODS
  A single tertiary referral centre ultrasound database was searched for cases of suspected callosal anomalies between 2003 and 2012. All subsequent ultrasound scans, MRIs, neonatal imaging, postmortem investigations and birth records were reviewed. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying congenital anomalies.
  
  
  RESULTS
  Forty-three cases of callosal anomaly were detected; 60 % were investigated by FMRI revealing additional diagnoses in 23 %; half of which were anomalies of cortical development. Of those considered isolated who underwent FMRI, 21 % were diagnosed with additional anomalies, changing the classification to a complex callosal anomaly.
  
  
  CONCLUSIONS
  In cases of callosal anomaly suspected on ultrasound, FMRI provides greater certainty and the potential to identify significant additional anomalies. The additional information may alter or clarify prognosis and help parents to better understand the pathology, allowing for informed decisions about the pregnancy to be made. However, some cases may still be diagnosed with additional anomalies after delivery and parents should be aware of such limitations of antenatal imaging.
authors.affiliation: Department of Perinatal Medicine, Pregnancy Research Centre, The Royal Women's Hospital, Melbourne, Australia, shwabiii@gmail.com.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bell
authors.forename: Edward
authors.initials: E
authors.lastname: O'Mahony
authors.forename: A Michelle
authors.initials: AM
authors.lastname: Fink
authors.forename: Nicole
authors.initials: N
authors.lastname: Woodrow
authors.forename: Karen
authors.initials: K
authors.lastname: Reidy
authors.forename: Ricardo
authors.initials: R
authors.lastname: Palma-Dias
mesh_terms: D061085:Agenesis of Corpus Callosum / Q000000981:diagnostic imaging; D001921:Brain / Q000002:abnormalities*; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*