title: Relationship between sum of the four limbs' pulse pressure and brachial-ankle pulse wave velocity and atherosclerosis risk factors in Chinese adults.
abstract: The aim of the present study was to analyze the relationship between the sum of the four limbs' pulse pressure (Sum-PP) and brachial-ankle pulse wave velocity (baPWV) and atherosclerosis risk factors and evaluate the feasibility of Sum-PP in diagnosing atherosclerosis systemically. For the purpose, a cross-sectional study was conducted on the basis of medical information of 20748 adults who had a health examination in our hospital. Both Sum-PP and baPWV exhibited significant variations among different human populations grouped by gender, smoking, drinking, and age. Interestingly, Sum-PP had similar varying tendency with baPWV in different populations. And further study in different populations showed that Sum-PP was significantly positively related to baPWV. We also investigated the relationship between Sum-PP, baPWV, and cardiovascular risk factors, respectively. We found that both Sum-PP and baPWV had significant positive correlation with atherosclerosis risk factors while both of them were negatively related to HDL-c. In addition, there was a significant close correlation between Sum-PP and baPWV in the whole population (r = 0.4616, P < 0.0001). Thus, Sum-PP is closely related to baPWV and is of important value for clinical diagnosis of atherosclerosis.
authors.affiliation: The Chinese PLA General Hospital Health Science Center, FuXing Road 28, Beijing 100853, China.
authors.forename: Yansong
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China.
authors.forename: Zongbin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shu
authors.affiliation: Department of Geriatric Endocrinology, PLA General Hospital, Beijing 100853, China.
authors.forename: Minyan
authors.initials: M
authors.lastname: Liu
authors.affiliation: The Chinese PLA General Hospital Health Science Center, FuXing Road 28, Beijing 100853, China.
authors.forename: Zhilai
authors.initials: Z
authors.lastname: Chen
authors.affiliation: The Chinese PLA General Hospital Health Science Center, FuXing Road 28, Beijing 100853, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Huang
mesh_terms: D055109:Ankle Brachial Index / Q000379:methods; D044466:Asian People; D050197:Atherosclerosis / Q000209:etiology* / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D005121:Extremities / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000379:methods; D012306:Risk; D012307:Risk Factors