title: One-pot three-component strategy for functionalized 2-aminoimidazoles via ring opening of α-nitro epoxides.
abstract: Functionalized 2-aminoimidazole derivatives have been synthesized via a three-component domino reaction of α-nitroepoxides and cyanamide with a series of amines under mild conditions without the need for any additives. This reaction represents a practical process for the facile conversion of α-nitroepoxides to 2-aminoimidazoles via ring opening of epoxides.
authors.affiliation: Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University , 866 Yuhangtang Road, Zijin Campus, Hangzhou 310058, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Guo
authors.forename: Wenteng
authors.initials: W
authors.lastname: Chen
authors.forename: Binhui
authors.initials: B
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Weixing
authors.initials: W
authors.lastname: Qi
authors.forename: Guolin
authors.initials: G
authors.lastname: Zhang
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu