title: Circulating microRNAs as clinical biomarkers in the predictions of pregnancy complications.
abstract: Predicting pregnancy complications is a major topic for clinicians and biologists for maternal and fetal monitoring. Noninvasive biomarkers in maternal blood such as circulating microRNAs (miRNAs) are promising molecules to predict pregnancy disorders. miRNAs are noncoding short RNAs that regulate mRNA expression by repressing the translation or cleaving the transcript. miRNAs are released to the extracellular systemic circulation via exosomes. The discovery of plasma- or serum-derived miRNAs and of free-circulating exosomes that contain miRNAs provides useful information about the physiological or pathophysiological roles of the miRNAs. Specific placental miRNAs are present in maternal plasma in different ways depending on whether the pregnancy is normal or pathological or if there is no pregnancy. This paper focuses on placental miRNAs and extracellular miRNAs to the placenta whose misregulation could lead to pregnancy complications.
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Fœtale, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
authors.forename: Marthe
authors.initials: M
authors.lastname: Tsochandaridis
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Centre Pluridisciplinaire de Diagnostic Prénatal, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Nasca
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Fœtale, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France ; Assistance Publique-Hôpitaux de Marseille, Centre Pluridisciplinaire de Diagnostic Prénatal, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Toga
authors.affiliation: Assistance Publique-Hôpitaux de Marseille, Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Fœtale, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France ; Assistance Publique-Hôpitaux de Marseille, Centre Pluridisciplinaire de Diagnostic Prénatal, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Levy-Mozziconacci
mesh_terms: D015415:Biomarkers / Q000097:blood*; D055354:Exosomes / Q000378:metabolism / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D010920:Placenta / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000235:genetics / Q000473:pathology
chemical_list: D015415:Biomarkers; D035683:MicroRNAs