title: [Opioids--triggers of adaptive phenomenon of ischemic preconditioning of heart].
abstract: It was established that short-term ischemia/reperfusion evokes an increase in myocardial tissue of enkephalin levels. A blockade of delta-opioid receptors abolishes the cardioprotective effect of ischemic preconditioning both in vivo and in vitro. An inhibition of kappa-opioid receptors abolishes the cardioprotective effect of ischemic preconditioning only in vitro. Agonists of mu-, delta1- delta- and kappa1-opioid receptors mimic the cardioprotective effect of preconditioning. Consequently, it can be argued that endogenous opioid peptides are triggers of ischemic preconditioning.
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: N V
authors.initials: NV
authors.lastname: Naryzhnaia
authors.forename: Iu K
authors.initials: IuK
authors.lastname: Podoksenov
authors.forename: A G
authors.initials: AG
authors.lastname: Mrochek
authors.forename: A S
authors.initials: AS
authors.lastname: Gorbunov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Tsibul'nikov
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D009206:Myocardium / Q000378:metabolism*; D018847:Opioid Peptides / Q000378:metabolism*; D011957:Receptors, Opioid / Q000819:agonists* / Q000378:metabolism*
chemical_list: D018847:Opioid Peptides; D011957:Receptors, Opioid