title: Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients.
abstract: OBJECTIVE
  To see if SNPs could help predict response to biological therapy using adalimumab (ADA) in Crohn's disease (CD).
  
  
  METHODS
  IBDQ index and CRP levels were used to monitor therapy response. We genotyped 31 CD-associated genes in 102 Slovenian CD patients.
  
  
  RESULTS
  The strongest association for treatment response defined as decrease in CRP levels was found for ATG16L1 SNP rs10210302. Additional SNPs in 7 out of 31 tested CD-associated genes (PTGER4, CASP9, IL27, C11orf30, CCNY, IL13, NR1I2) showed suggestive association with ADA response.
  
  
  CONCLUSIONS
  Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment. Original submitted 24 September 2014; Revision submitted 1 December 2014.
authors.affiliation: University Medical Centre Maribor, Ljubljanska 5, Maribor, Slovenia.
authors.forename: Silvo
authors.initials: S
authors.lastname: Koder
authors.forename: Katja
authors.initials: K
authors.lastname: Repnik
authors.forename: Ivan
authors.initials: I
authors.lastname: Ferkolj
authors.forename: Cvetka
authors.initials: C
authors.lastname: Pernat
authors.forename: Pavel
authors.initials: P
authors.lastname: Skok
authors.forename: Rinse K
authors.initials: RK
authors.lastname: Weersma
authors.forename: Uroš
authors.initials: U
authors.lastname: Potočnik
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use*; D000328:Adult; D000071183:Autophagy-Related Proteins; D002097:C-Reactive Protein / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics*; D003424:Crohn Disease / Q000235:genetics* / Q000628:therapy*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017524:Slovenia; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D000068879:Adalimumab
keywords: Crohn's disease; adalimumab; biological drugs; pharmacogenomics; single nucleotide polymorphism