title: Hemangiomas and the eye.
abstract: Infantile hemangiomas are a common vascular birthmark with heterogeneous presentations and unique growth characteristics with early rapid growth and eventual self-involution. Hemangiomas that develop around the eye have the potential for inducing amblyopia by several mechanisms and may eventually result in permanent visual impairment in otherwise healthy infants. Segmental periocular hemangiomas carry the additional risk of associated structural anomalies and PHACE syndrome. In recent years, the treatment of periocular hemangiomas has been revolutionized by the serendipitous discovery of the effectiveness of beta-blockers (systemic and topical), with most experts viewing these as first-line therapies. The management of periocular hemangiomas should involve a close partnership between an ophthalmologist and dermatologist or other relevant specialists familiar with the unique clinical features, differential diagnosis, treatment approaches, and potential complications.
authors.affiliation: Department of Dermatology, University of California-San Francisco School of Medicine, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115.
authors.forename: Allyson A
authors.initials: AA
authors.lastname: Spence-Shishido
authors.affiliation: The Smith-Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115.
authors.forename: William V
authors.initials: WV
authors.lastname: Good
authors.affiliation: Pediatric Dermatology Section, Department of Dermatology, Hospital de la Santa Creu I Sant Pau, S Antoni M Claret 167, 08025 Barcelona, Spain.
authors.forename: Eulalia
authors.initials: E
authors.lastname: Baselga
authors.affiliation: Department of Dermatology, University of California-San Francisco School of Medicine, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115. Electronic address: FriedenI@derm.ucsf.edu.
authors.forename: Ilona J
authors.initials: IJ
authors.lastname: Frieden
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D005153:Facial Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D018324:Hemangioma, Capillary / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D011379:Prognosis; D011433:Propranolol / Q000627:therapeutic use; D012075:Remission, Spontaneous
chemical_list: D000305:Adrenal Cortex Hormones; D011433:Propranolol