title: The Roles of the Stem Cell-Controlling Sox2 Transcription Factor: from Neuroectoderm Development to Alzheimer's Disease?
abstract: Sox2 is a component of the core transcriptional regulatory network which maintains the totipotency of the cells during embryonic preimplantation period, the pluripotency of embryonic stem cells, and the multipotency of neural stem cells. This maintenance is controlled by internal loops between Sox2 and other transcription factors of the core such as Oct4, Nanog, Dax1, and Klf4, downstream proteins of extracellular ligands, epigenetic modifiers, and miRNAs. As Sox2 plays an important role in the balance between stem cells maintenance and commitment to differentiated lineages throughout the lifetime, it is supposed that Sox2 could regulate stem cells aging processes. In this review, we provide an update concerning the involvement of Sox2 in neurogenesis during normal aging and discuss its possible role in Alzheimer's disease.
authors.affiliation: Research Center for Neuroscience, Mahidol University, Nakhon Pathom, 73170, Thailand.|Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand.
authors.forename: Golmaryam
authors.initials: G
authors.lastname: Sarlak
authors.affiliation: Research Center for Neuroscience, Mahidol University, Nakhon Pathom, 73170, Thailand. bruno.vin@mahidol.ac.th.|Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, 73170, Thailand. bruno.vin@mahidol.ac.th.|Centre National de la Recherche Scientifique, 2 rue Michel Ange, 75016, Paris, France. bruno.vin@mahidol.ac.th.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vincent
mesh_terms: D000375:Aging / Q000473:pathology; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D000090062:Kruppel-Like Factor 4; D009420:Nervous System / Q000378:metabolism / Q000473:pathology; D054258:Neural Plate / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism*; D055748:SOXB1 Transcription Factors / Q000378:metabolism*
chemical_list: C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D055748:SOXB1 Transcription Factors
keywords: Aging; Alzheimer’s disease; Neural stem cells; Neurogenesis; Sox2; Transcription factors