title: Biogenic silver and gold nanoparticles synthesized using red ginseng root extract, and their applications.
abstract: In the present study, we report a green methodology for the synthesis of silver and gold nanoparticles, using the root extract of the herbal medicinal plant Korean red ginseng. The silver and gold nanoparticles were synthesized within 1 h and 10 min respectively. The nanoparticles generated were not aggregated, and remained stable for a long time, which suggests the nature of nanoparticles. The phytochemicals and ginsenosides present in the root extract assist in reducing and stabilizing the synthesized nanoparticles. The red ginseng root extract-generated silver nanoparticles exhibit antimicrobial activity against pathogenic microorganisms including Vibrio parahaemolyticus, Staphylococcus aureus, Bacillus cereus, and Candida albicans. In addition, the silver nanoparticles exhibit biofilm degrading activity against S. aureus and Pseudomonas aeruginosa. Thus, the present study opens up a new possibility of synthesizing silver and gold nanoparticles in a green and rapid manner using Korean red ginseng root extract, and explores their biomedical applications.
authors.affiliation: a Department of Oriental Medicinal Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Singh
authors.affiliation: a Department of Oriental Medicinal Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Yeon Ju
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: a Department of Oriental Medicinal Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Ramya
authors.initials: R
authors.lastname: Mathiyalagan
authors.affiliation: b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Agamy Farh
authors.affiliation: a Department of Oriental Medicinal Biotechnology , College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.|b Graduate School of Biotechnology and Ginseng Bank, College of Life Sciences, Kyung Hee University , Yongin , 446-701 , Republic of Korea.
authors.forename: Deok Chun
authors.initials: DC
authors.lastname: Yang
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000235:genetics; D002176:Candida albicans / Q000254:growth & development; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D005894:Panax / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D012834:Silver; D006046:Gold
keywords: Korean red ginseng root extract; antimicrobial activity; biofilm degrading activity; gold nanoparticles; silver nanoparticles