title: Concurrent bisphosphonate-related bilateral atypical subtrochanteric fractures and osteonecrosis of the jaw on bone scintigraphy.
abstract: An 82-year-old woman presented with bilateral thigh pain. She had pain in her right thigh operated for a low-trauma fracture 2 years earlier and newly developed pain in her left thigh without trauma. A whole-body bone scan revealed increased tracer uptake in her bilateral subtrochanteric femoral shafts and in the right mandible without evidence of metastatic bone disease. She had been taking bisphosphonates for 7 years to treat osteoporosis and was soon diagnosed with atypical subtrochanteric fractures and bisphosphonate-related osteonecrosis of the jaw. The bone scan simultaneously identified 2 serious adverse effects of long-term use of bisphosphonates.
authors.affiliation: From the *Department of Internal Medicine, and †Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jo Eun
authors.initials: JE
authors.lastname: Kim
authors.forename: Mijin
authors.initials: M
authors.lastname: Yun
authors.forename: Sung-Kil
authors.initials: SK
authors.lastname: Lim
authors.forename: Yumie
authors.initials: Y
authors.lastname: Rhee
mesh_terms: D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006620:Hip Fractures / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D007568:Jaw / Q000000981:diagnostic imaging / Q000473:pathology; D010020:Osteonecrosis / Q000000981:diagnostic imaging* / Q000209:etiology; D011877:Radionuclide Imaging
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates