title: Optimization of Aqueous SI-ATRP Grafting of Poly(Oligo(Ethylene Glycol) Methacrylate) Brushes from Benzyl Chloride Macroinitiator Surfaces.
abstract: Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.
authors.affiliation: Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia. andrew.rodda@monash.edu.|CSIRO Materials Science and Engineering, Bayview Avenue, Clayton 3168, Victoria, Australia, and Cooperative Research Centre for Polymers, 8 Redwood Drive, Notting Hill, 3168, Victoria, Australia. andrew.rodda@monash.edu.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Rodda
authors.affiliation: Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ercole
authors.affiliation: School of Engineering, The Australian National University, Canberra, 0200, Australian Capital Territory, Australia.
authors.forename: David R
authors.initials: DR
authors.lastname: Nisbet
authors.affiliation: Department of Materials Engineering, Monash University, Wellington Rd, Clayton, 3800, Victoria, Australia.
authors.forename: John S
authors.initials: JS
authors.lastname: Forsythe
authors.affiliation: CSIRO Materials Science and Engineering, Bayview Avenue, Clayton 3168, Victoria, Australia, and Cooperative Research Centre for Polymers, 8 Redwood Drive, Notting Hill, 3168, Victoria, Australia.
authors.forename: Laurence
authors.initials: L
authors.lastname: Meagher
mesh_terms: D000818:Animals; D001593:Benzyl Compounds / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D008689:Methacrylates / Q000737:chemistry*; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001593:Benzyl Compounds; D008689:Methacrylates; C524499:polyethylene glycol methacrylate; D011092:Polyethylene Glycols; C021292:benzyl chloride
keywords: aqueous ATRP; benzyl chloride; macroinitiator; protein fouling; surface initiated ATRP