title: Bioactive glycosides from the African medicinal plant Boerhavia erecta L.
abstract: Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an unreported glycoside 4, 2,3-dihydroxypropylbenzoate-3-O-β-[4″-methoxy] glucuronide as well as seven known glycosides (1-3, 5-8). The major isolate 5 and 8 indicated a significant inhibition against HIV integrase (IC50 10 and 22 μg/mL, respectively). The extracts and isolates were also tested for anti-malarial activity, but insignificant activity was observed.
authors.affiliation: a School of Chemistry, University of Wollongong , Northfields Avenue, Wollongong , New South Wales 2522 , Australia.
authors.forename: Ari S
authors.initials: AS
authors.lastname: Nugraha
authors.forename: Adama
authors.initials: A
authors.lastname: Hilou
authors.forename: Nicholas
authors.initials: N
authors.lastname: Vandegraaff
authors.forename: David I
authors.initials: DI
authors.lastname: Rhodes
authors.forename: Rachada
authors.initials: R
authors.lastname: Haritakun
authors.forename: Paul A
authors.initials: PA
authors.lastname: Keller
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification; D002050:Burkina Faso; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D019428:HIV Integrase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D039281:Nyctaginaceae / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D006027:Glycosides; D019428:HIV Integrase Inhibitors; D010936:Plant Extracts
keywords: African medicinal plant; Boerhavia erecta; anti-HIV integrase activity; anti-malarial activity; glycosides