title: Disseminated rhinovirus C8 infection with infectious virus in blood and fatal outcome in a child with repeated episodes of bronchiolitis.
abstract: We report a fatal case of acute lower respiratory tract disease with human rhinovirus C (HRV-C) as the unique cause in a 19-month-old girl with a history of repeated episodes of bronchiolitis. HRV-C type 8 nucleic acids were observed in respiratory, stool, and cerebrospinal fluid samples, and infectious virions were isolated from patient serum after inoculation onto reconstituted airway epithelia.
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, Grenoble, France jlupo@chu-grenoble.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Lupo
authors.affiliation: French National Enterovirus/Parechovirus Reference Centre, Hospices Civils de Lyon, Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Schuffenecker
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Morel-Baccard
authors.affiliation: Paediatric Intensive Care Unit, University Hospital of Grenoble, Grenoble, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Bardet
authors.affiliation: Paediatric Intensive Care Unit, University Hospital of Grenoble, Grenoble, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Payen
authors.affiliation: Laboratory of Virology, University of Geneva and University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kaiser
authors.affiliation: Epithelix Sárl, Plan-les-Ouates, Geneva, Switzerland.
authors.forename: Samuel
authors.initials: S
authors.lastname: Constant
authors.affiliation: Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Johannes Alexander
authors.initials: JA
authors.lastname: Lobrinus
authors.affiliation: Division of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lin-Marq
authors.affiliation: French National Enterovirus/Parechovirus Reference Centre, Hospices Civils de Lyon, Lyon, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.affiliation: Laboratory of Virology, University Hospital of Grenoble, Grenoble, France Unit of Virus Host Cell Interactions UMI 3265 UJF-EMBL-CNRS, Grenoble, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
authors.affiliation: Laboratory of Virology, University of Geneva and University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Caroline
authors.initials: C
authors.lastname: Tapparel
mesh_terms: D001769:Blood / Q000821:virology*; D001988:Bronchiolitis / Q000150:complications / Q000209:etiology*; D002555:Cerebrospinal Fluid / Q000821:virology; D017809:Fatal Outcome; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D007223:Infant; D010850:Picornaviridae Infections / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D012137:Respiratory System / Q000821:virology; D012229:Rhinovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014766:Viremia / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D014776:Virus Cultivation