title: In situ synthesis of metal-organic frameworks in a porous polymer monolith as the stationary phase for capillary liquid chromatography.
abstract: In this study, HKUST-1 was synthesized in situ on the porous polymer monolith as the stationary phase for capillary liquid chromatography (cLC). The unique carboxyl functionalized poly(methacrylic acid-co-ethylene dimethacrylate) (poly(MAA-co-EDMA)) monolith was used as a support to directly grow HKUST-1 by a controlled layer-by-layer self-assembly strategy. X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectrometry, and Fourier transform infrared spectroscopy of the resulting HKUST-1-poly(MAA-co-EDMA) monoliths indicated that HKUST-1 was successfully grafted onto the pore surface of the poly(MAA-co-EDMA) monolith. The column performance of HKUST-1-poly(MAA-co-EDMA) monoliths for the separation of various small molecules, such as benzenediols, xylenes, ethylbenzenes, and styrenes, was evaluated. The chromatographic performance was found to improve with increasing HKUST-1 density, and the column efficiencies and resolutions of HKUST-1-poly(MAA-co-EDMA) monoliths were 18 320-19 890 plates m(-1) and 1.62-6.42, respectively, for benzenediols. The HKUST-1-poly(MAA-co-EDMA) monolith displayed enhanced resolution for the separation of positional isomers when compared to the traditional C18 and HKUST-1 incorporated polymer monoliths. Hydrophobic, π-π, and hydrogen bonding interactions within the HKUST-1-poly(MAA-co-EDMA) monolith were observed in the separation of small molecules. The results showed that the HKUST-1-poly(MAA-co-EDMA) monoliths are promising stationary phases for cLC.
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin 541004, P. R. China. fangguiye@163.com.
authors.forename: Shengchao
authors.initials: S
authors.lastname: Yang
authors.forename: Fanggui
authors.initials: F
authors.lastname: Ye
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.forename: Shufen
authors.initials: S
authors.lastname: Shen
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000302:isolation & purification; D060326:Chemistry Techniques, Synthetic; D002853:Chromatography, Liquid / Q000379:methods*; D007536:Isomerism; D000073396:Metal-Organic Frameworks; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D016062:Porosity
chemical_list: D000475:Alkenes; D000073396:Metal-Organic Frameworks; D009942:Organometallic Compounds; D011108:Polymers; C539834:bis(1,3,5-benzenetricarboxylate)tricopper(II); C000607445:poly(MAA-co-EDMA); D019904:Polymethyl Methacrylate