title: Placental pathology in smoking and non-smoking preeclamptic women.
abstract: OBJECTIVE
  To ascertain whether the protective effect of smoking during preeclampsia (PE) can be visualized in the placenta.
  
  
  METHODS
  The study cohort consisted of placentas (n = 523) from pregnancies complicated by PE, delivered at Karolinska University Hospital in Stockholm during the period 2000-2009. Of the women included in the study, 488 were non-smokers and 35 were smokers at first visit to maternity care. Outcome variables were placental infarctions and decidual arteriopathy.
  
  
  RESULTS
  Infarctions (affecting ≥5% of the placental tissue) were found in 15.6% of the placentas from non-smokers and in 25.7% of the placentas from smokers (OR 1.88: CI 0.84-4.16, p = 0.12). Decidual arteriopathy was found in 27.5% of the placentas from non-smokers and in 40.0% of the placentas from smokers (1.76: CI 0.87-3.56, p = 0.12). When diagnosed histopathologically, placental abruption was found in 15.4% among non-smokers and in 17.1% among smokers (1.14: CI 0.46-2.84, p = 0.98). Those differences did not show any statistical significance.
  
  
  CONCLUSIONS
  No significant differences concerning placental infarctions, decidual arteriopathy or abruption were found between preeclamptic placentas from non-smokers compared to smokers.
authors.affiliation: a Department of Clinical Science , Intervention and Technology, Division of Obstetrics and Gynecology, CLINTEC, Karolinska Institutet , Stockholm , Sweden .|b Örnsköldsviks Hospital , Örnsköldsvik , Sweden .
authors.forename: Marie Therese
authors.initials: MT
authors.lastname: Vinnars
authors.affiliation: a Department of Clinical Science , Intervention and Technology, Division of Obstetrics and Gynecology, CLINTEC, Karolinska Institutet , Stockholm , Sweden .
authors.forename: Sara
authors.initials: S
authors.lastname: Falkare
authors.affiliation: c Department of Laboratory Medicine , Division of Pathology, Karolinska Institutet , Stockholm , Sweden , and.|d Karolinska University Hospital , Stockholm , Sweden.
authors.forename: Nikos
authors.initials: N
authors.lastname: Papadogiannakis
authors.affiliation: a Department of Clinical Science , Intervention and Technology, Division of Obstetrics and Gynecology, CLINTEC, Karolinska Institutet , Stockholm , Sweden .|d Karolinska University Hospital , Stockholm , Sweden.
authors.forename: Josefine
authors.initials: J
authors.lastname: Nasiell
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology / Q000473:pathology; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000453:epidemiology / Q000473:pathology; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000473:pathology*; D012907:Smoking / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult
keywords: Abruption; arteriopathy; hypertension; infarction; non-smoker; placenta; smoker