title: Gender Specificity of a Genetic Variant of Androgen Receptor and Risk of Coronary Artery Disease.
abstract: BACKGROUND
  Androgens are known to influence the risk of developing cardiovascular diseases. This study aims at investigating the possible association between G1733A polymorphism in the coding region of androgen receptor (AR) gene and premature coronary artery disease (CAD).
  
  
  METHODS
  A total of 460 Greek subjects were investigated for the G1733A polymorphism. The patient group consisted of 250 CAD individuals, aged less than 58 years, while 210 healthy individuals served as controls. Genotyping was performed using the PCR-RFLP method.
  
  
  RESULTS
  Significant differences in genotype distribution (P = 0.0067) and allele frequencies (P = 0.0060) have been observed between patients and controls in the women's subgroup. Conversely, the genotype/allele frequencies were similar between patients and controls in the subgroup of men.
  
  
  CONCLUSIONS
  We may conclude that the G1733A polymorphism of AR gene could be a useful genetic marker for the assessment of a woman's risk for CAD in our Caucasian Greek population.
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Agiannitopoulos
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
authors.forename: Angeliki
authors.initials: A
authors.lastname: Bakalgianni
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
authors.forename: Eirini
authors.initials: E
authors.lastname: Marouli
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
authors.forename: Ioanna
authors.initials: I
authors.lastname: Zormpa
authors.affiliation: First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Manginas
authors.affiliation: First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Papamenzelopoulos
authors.affiliation: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
authors.forename: Klea
authors.initials: K
authors.lastname: Lamnissou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen
keywords: androgen receptor; coronary artery disease; polymorphism; risk factor