title: Immune complexes: not just an innocent bystander in chronic viral infection.
abstract: Understanding of how persistent viral infection impacts humoral immunity is incomplete. In this issue of Immunity, Wieland et al. (2015) and Yamada et al. (2015) find that high amounts of IgG-antigen complexes formed during chronic lymphocytic choriomeningitis infection can interfere with Fcγ-receptor-mediated effector activities, potentially contributing to immune dysfunction.
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA.
authors.forename: Taia T
authors.initials: TT
authors.lastname: Wang
authors.affiliation: The Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA. Electronic address: ravetch@mail.rockefeller.edu.
authors.forename: Jeffrey V
authors.initials: JV
authors.lastname: Ravetch
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000276:immunology*; D057131:Immune Evasion / Q000276:immunology*; D008212:Lymphocyte Depletion; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D017452:Receptors, IgG / Q000037:antagonists & inhibitors* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D017452:Receptors, IgG