title: A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
abstract: Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
authors.affiliation: Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main (Germany).
authors.forename: Friederike I
authors.initials: FI
authors.lastname: Nollmann
authors.forename: Antje K
authors.initials: AK
authors.lastname: Heinrich
authors.forename: Alexander O
authors.initials: AO
authors.lastname: Brachmann
authors.forename: Christophe
authors.initials: C
authors.lastname: Morisseau
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Mukherjee
authors.forename: Ángel M
authors.initials: ÁM
authors.lastname: Casanova-Torres
authors.forename: Frederic
authors.initials: F
authors.lastname: Strobl
authors.forename: David
authors.initials: D
authors.lastname: Kleinhans
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kinski
authors.forename: Katharina
authors.initials: K
authors.lastname: Schultz
authors.forename: Michael L
authors.initials: ML
authors.lastname: Beeton
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Ya-Yun
authors.initials: YY
authors.lastname: Chu
authors.forename: Long
authors.initials: L
authors.lastname: Phan Ke
authors.forename: Aunchalee
authors.initials: A
authors.lastname: Thanwisai
authors.forename: Kenan A J
authors.initials: KA
authors.lastname: Bozhüyük
authors.forename: Narisara
authors.initials: N
authors.lastname: Chantratita
authors.forename: Friedrich
authors.initials: F
authors.lastname: Götz
authors.forename: Nick R
authors.initials: NR
authors.lastname: Waterfield
authors.forename: Andreas
authors.initials: A
authors.lastname: Vilcinskas
authors.forename: Ernst H K
authors.initials: EH
authors.lastname: Stelzer
authors.forename: Heidi
authors.initials: H
authors.lastname: Goodrich-Blair
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hammock
authors.forename: Helge B
authors.initials: HB
authors.lastname: Bode
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007313:Insecta; D020637:Photorhabdus / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D004791:Enzyme Inhibitors; D014508:Urea; D004851:Epoxide Hydrolases; C055698:juvenile hormone epoxide hydrolase
keywords: Photorhabdus; biosynthesis; entomopathogenic bacteria; juvenile hormone epoxide hydrolase inhibitor; natural products