title: A case of anti-MDA5-positive rapidly progressive interstitial lung disease in a patient with clinically amyopathic dermatomyositis ameliorated by rituximab, in addition to standard immunosuppressive treatment.
abstract: Rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) associated with antibodies to melanoma differentiation-associated gene5 (MDA5) results in a high mortality rate. We experienced a case of anti-MDA5-positive RP-ILD of CADM which showed a response to rituximab, although there was no significant effect due to standard immunosuppressive treatment. This case suggests that rituximab has the potential to offer an effective agent for the treatment of anti-MDA5-positive RP-ILD of CADM.
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Yamaguchi
authors.initials: Y
authors.lastname: Koichi
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Yamaguchi
authors.initials: Y
authors.lastname: Aya
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Uchida
authors.initials: U
authors.lastname: Megumi
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Kono
authors.initials: K
authors.lastname: Shunichi
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Suzuki
authors.initials: S
authors.lastname: Masafumi
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Masubuchi
authors.initials: M
authors.lastname: Hiroaki
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Kanbe
authors.initials: K
authors.lastname: Masahiko
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Kitahara
authors.initials: K
authors.lastname: Shinsuke
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Ueno
authors.initials: U
authors.lastname: Manabu
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Hara
authors.initials: H
authors.lastname: Kenichiro
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Aoki
authors.initials: A
authors.lastname: Fumiaki
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Aoki
authors.initials: A
authors.lastname: Nozomi
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Maeno
authors.initials: M
authors.lastname: Toshitaka
authors.affiliation: b Department of Dermatology , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Yamanaka
authors.initials: Y
authors.lastname: Masayoshi
authors.affiliation: b Department of Dermatology , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Kishi
authors.initials: K
authors.lastname: Chikako
authors.affiliation: c Department of Dermatology , Nagoya University Graduate School of Medicine , Nagoya , Japan.
authors.forename: Muro
authors.initials: M
authors.lastname: Yoshinao
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Suga
authors.initials: S
authors.lastname: Tatsuo
authors.affiliation: a Department of Allergy and Respiratory Medicine , Gunma University Graduate School of Medicine , Maebashi , Japan.
authors.forename: Kurabayashi
authors.initials: K
authors.lastname: Masahiko
mesh_terms: D000368:Aged; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D000072640:Interferon-Induced Helicase, IFIH1 / Q000276:immunology; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000069283:Rituximab / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D000069283:Rituximab; C452815:IFIH1 protein, human; D000072640:Interferon-Induced Helicase, IFIH1
keywords: Anti-MDA5 antibody; Dermatomyositis; Interstitial lung disease; Rituximab