title: The impact of sporotrichosis in HIV-infected patients: a systematic review.
abstract: Sporotrichosis is a fungal infection of man and animals caused by Sporothrix complex. It usually presents as a lymphocutaneous form, but disseminated disease may occur. Given the paucity of data about HIV/AIDS and sporotrichosis co-infection, a systematic review of reported cases of HIV-associated sporotrichosis found via Pubmed (1984-2013) was done. A total of 39 papers were included, and 58 patients' data analyzed. Thirty-three (56.9 %) cases were from Brazil and 18 (31 %) from the USA. Patients' mean age was 37.8 ± 10.4 years; males predominated (84.5 %). The median CD4(+) cell count was 97 cells/mm(3). The most common clinical forms were disseminated and disseminated cutaneous with 33 (56.9 %) and 10 (17.5 %) patients, respectively. There was a correlation between CD4(+) count and clinical categories (p = 0.002). Mortality was 30 % and there was a correlation between central nervous system involvement and death (p < 0.001).
authors.affiliation: Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Avenida Brasil 4365, Manguinhos, Rio de Janeiro, CEP 21045-900, Brazil, jose.moreira@ipec.fiocruz.br.
authors.forename: José A S
authors.initials: JA
authors.lastname: Moreira
authors.forename: Dayvison F S
authors.initials: DF
authors.lastname: Freitas
authors.forename: Cristiane C
authors.initials: CC
authors.lastname: Lamas
mesh_terms: D017677:Age Distribution; D000818:Animals; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D017678:Sex Distribution; D013175:Sporothrix / Q000302:isolation & purification*; D013174:Sporotrichosis / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology