title: Direct synthesis of 2-aryl-4-quinolones via transition-metal-free intramolecular oxidative C(sp(3))-H/C(sp(3))-H coupling.
abstract: A novel, metal-free oxidative intramolecular Mannich reaction was developed between secondary amines and unmodified ketones, affording a simple and direct access to a broad range of 2-arylquinolin-4(1H)-ones through C(sp(3))-H activation/C(sp(3))-C(sp(3)) bond formation from readily available N-arylmethyl-2-aminophenylketones, using TEMPO as the oxidant and KO(t)Bu as the base.
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Lin
authors.forename: Li-Rui
authors.initials: LR
authors.lastname: Song
authors.forename: Ya-Qiu
authors.initials: YQ
authors.lastname: Long
mesh_terms: D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D042462:4-Quinolones; D000814:Aniline Compounds; D007659:Ketones; D028561:Transition Elements