title: [Risk of second cancer after radiation therapy].
abstract: This review describes the secondary cancer after radiotherapy. Secondary cancer is a great concern for cancer survivors, especially for childhood cancer survivors not only because of their intrinsic high susceptibility to radiation but also because of successful achievement of longer survival. Recent advance of molecular biology reveals unique genomic changes, which distinguish radiation-induced tumors from spontaneous or chemically induced tumors.
authors.forename: Shizuko
authors.initials: S
authors.lastname: Kakinuma
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Shimada
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D002648:Child; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics; D019656:Loss of Heterozygosity; D016399:Lymphoma, T-Cell / Q000209:etiology; D008297:Male; D051379:Mice; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D011879:Radiotherapy Dosage; D012306:Risk; D012907:Smoking / Q000009:adverse effects
chemical_list: D018906:Antineoplastic Agents, Alkylating; C497238:Zfpn1a1 protein, mouse; D051740:Ikaros Transcription Factor