title: The role of pattern recognition receptors in the innate recognition of Candida albicans.
abstract: Candida albicans is both a commensal microorganism in healthy individuals and a major fungal pathogen causing high mortality in immunocompromised patients. Yeast-hypha morphological transition is a well known virulence trait of C. albicans. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs). In this review, we summarize the PRRs involved in the recognition of C. albicans in epithelial cells, endothelial cells, and phagocytic cells separately. We figure out the differential recognition of yeasts and hyphae, the findings on PRR-deficient mice, and the discoveries on human PRR-related single nucleotide polymorphisms (SNPs).
authors.affiliation: a Changzheng Hospital ; Second Military Medical University ; Shanghai , China.
authors.forename: Nan-Xin
authors.initials: NX
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Hu
authors.forename: Lan
authors.initials: L
authors.lastname: Yan
authors.forename: Yuan-Ying
authors.initials: YY
authors.lastname: Jiang
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity* / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D042783:Endothelial Cells / Q000276:immunology / Q000382:microbiology; D004847:Epithelial Cells / Q000276:immunology / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D025301:Hyphae / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D007113:Immunity, Innate; D051379:Mice; D010586:Phagocytes / Q000276:immunology / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition
keywords: Candida albicans; epithelial cells; innate immunity; pattern recognition receptors; phagocytic cells