title: The actin depolymerizing factor (ADF)/cofilin signaling pathway and DNA damage responses in cancer.
abstract: The actin depolymerizing factor (ADF)/cofilin protein family is essential for actin dynamics, cell division, chemotaxis and tumor metastasis. Cofilin-1 (CFL-1) is a primary non-muscle isoform of the ADF/cofilin protein family accelerating the actin filamental turnover in vitro and in vivo. In response to environmental stimulation, CFL-1 enters the nucleus to regulate the actin dynamics. Although the purpose of this cytoplasm-nucleus transition remains unclear, it is speculated that the interaction between CFL-1 and DNA may influence various biological responses, including DNA damage repair. In this review, we will discuss the possible involvement of CFL-1 in DNA damage responses (DDR) induced by ionizing radiation (IR), and the implications for cancer radiotherapy.
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. tracysirotan@hotmail.com.
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Chang
authors.affiliation: Division of Radiation Oncology, Taipei City Hospital RenAi Branch, Taipei 106, Taiwan. dab03@tpech.gov.tw.
authors.forename: Jyh-Der
authors.initials: JD
authors.lastname: Leu
authors.affiliation: Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan. yjlee2@ym.edu.tw.|Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang-Ming University, Taipei 112, Taiwan. yjlee2@ym.edu.tw.
authors.forename: Yi-Jang
authors.initials: YJ
authors.lastname: Lee
mesh_terms: D008841:Actin Cytoskeleton; D051339:Actin Depolymerizing Factors / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy; D011839:Radiation, Ionizing; D015398:Signal Transduction
chemical_list: D051339:Actin Depolymerizing Factors; D000199:Actins; D064007:Ataxia Telangiectasia Mutated Proteins