title: Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy.
abstract: OBJECTIVE
  The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP).
  
  
  METHODS
  Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6(th) and the 9(th) month after the surgery.
  
  
  RESULTS
  Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF.
  
  
  CONCLUSIONS
  DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye.
authors.forename: Ebru Olgun
authors.initials: EO
authors.lastname: Erdemir
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Kirikkale University, Merkez, Kirikkale, Turkiye.
authors.forename: Meltem Karsiyaka
authors.initials: MK
authors.lastname: Hendek
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sıhhiye, Ankara, Turkiye.
authors.forename: H Gencay
authors.initials: HG
authors.lastname: Keceli
authors.affiliation: Department of Medical Microbiology, Faculty of Medicine, Kirikkale University, Merkez, Kirikkale, Turkiye.
authors.forename: Teoman Z
authors.initials: TZ
authors.lastname: Apan
keywords: Demineralized freeze-dried bone allograft; gingival crevicular fluid; interleukin-17; interleukin-8; soluble intercellular adhesion molecule-1