title: Design and simulation of proportional biological operational Mu-circuit.
abstract: It is challenging yet desirable to quantitatively control the expression of a target gene in practice. We design a device-Proportional Biological Operational Mu-circuit (P-BOM) incorporating AND/OR gate and operational amplifier into one circuit and explore its behaviors through simulation. The results imply that will be possible to regulate input-output proportionally by manipulating the RBS of hrpR, hrpS, tetR and output gene and used in the sensing of environmental weak signals such as dioxins.
authors.forename: Dechang
authors.initials: D
authors.lastname: Xu
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Cai
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Xiangmiao
authors.initials: X
authors.lastname: Zeng
authors.forename: Yujing
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Cuihong
authors.initials: C
authors.lastname: Dai
authors.forename: Aiju
authors.initials: A
authors.lastname: Hou
authors.forename: Dayou
authors.initials: D
authors.lastname: Cheng
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Li
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D025461:Feedback, Physiological / Q000502:physiology*; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*