title: [Association of kynurenine-3-monooxygenase gene with schizophrenia].
abstract: Neurotoxic products produced during tryptophan metabolism via the kynurenine pathway could be involved in schizophrenia pathogenesis. It has been shown that kynurenine-3-monooxygenase (KMO) is indirectly involved in these products' formation. KMO polymorphic loci rs2275163 (C/T) and rs1053230 (A/G) were examined in 187 schizophrenia patients and 229 healthy subjects. A genetic combination of allele T and genotype GG was observed more often in a patient group compared with healthy controls (p = 0.003, OR 2.0 (95% CI 1.2-2.9). In the latter group, this combination was associated with schizophrenia endophenotype (p = 0.04), which manifested in a higher expression of schizotypal personality traits assessed using the MMPI test.
authors.forename: V E
authors.initials: VE
authors.lastname: Golimbet
authors.forename: T V
authors.initials: TV
authors.lastname: Lezheiko
authors.forename: M V
authors.initials: MV
authors.lastname: Alfimova
authors.forename: L I
authors.initials: LI
authors.lastname: Abramova
authors.forename: N V
authors.initials: NV
authors.lastname: Kondrat'ev
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D050601:Kynurenine 3-Monooxygenase / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D050601:Kynurenine 3-Monooxygenase