title: Three spirostanol saponins and a flavane-O-glucoside from the fresh rhizomes of Tupistra chinensis.
abstract: Four new compounds, including three new spirostanol saponins [tupistroside G-I (1-3)] and a new flavane-O-glucoside [tupichiside A (4)], together with ten known compounds, were isolated from the fresh rhizomes of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. All compounds were tested in vitro for their cytotoxic activities against the Human LoVo and BGC-823 cell lines, and six of them were found to possess potent cytotoxicity. Compounds 2, 8 and 9 showed significant cytotoxicity against the tested tumor cell lines with IC50 values ranging from 0.2 to 0.9μM.
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China; Institute of Chemical Defense, Beijing 102205, China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Xiao
authors.affiliation: Humanwell Healthcare Group Co., Ltd, Wuhan 430075, China.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yin
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Shi-Jun
authors.initials: SJ
authors.lastname: Liu
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Guang-Jie
authors.initials: GJ
authors.lastname: Zhang
authors.affiliation: Guanganmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Heng-Wen
authors.initials: HW
authors.lastname: Chen
authors.affiliation: Beijing Institute of Disease Prevention and Control, 100071, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address: djx931314@163.com.
authors.forename: Jun-Xing
authors.initials: JX
authors.lastname: Dong
mesh_terms: D045744:Cell Line, Tumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification; D013150:Spirostans / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D005960:Glucosides; D012503:Saponins; D013150:Spirostans
keywords: Cytotoxicity; Flavane-O-glucoside; Spirostanol saponins; Tupichiside; Tupistra chinensis; Tupistroside