title: Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): clinical feasibility and dosimetric results of a single patient.
abstract: We herein report on a case of synchronous bilateral breast cancer patient undergoing adjuvant intensity-modulated whole breast with static angle tomotherapy (TomoDirect). The patient was treated with a hypofractionated schedule employing a simultaneous integrated boost approach. Radiotherapy schedule was 45 Gy/20 fractions (2.25 Gy daily) to the bilateral whole breast and 50 Gy/20 fractions (2.5 Gy daily) to the 2 lumpectomy cavities. Treatment was delivered over 4 weeks. Dosimetric results were robust with consistent target coverage and adequate normal tissue avoidance. Treatment was generally well-tolerated and acute toxicity profile was mild. The present report highlights the promising clinical feasibility of TomoDirect for bilateral breast irradiation.
authors.affiliation: Radiation Oncology Department, Tomotherapy Unit, Ospedale Regionale 'U. Parini', AUSL Valle d'Aosta, Aosta - Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.forename: Fernanda
authors.initials: F
authors.lastname: Migliaccio
authors.forename: Paolo
authors.initials: P
authors.lastname: Torielli
authors.forename: Piera
authors.initials: P
authors.lastname: Sciacero
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Girelli
authors.forename: Domenico
authors.initials: D
authors.lastname: Cante
authors.forename: Cecilia
authors.initials: C
authors.lastname: Arrichiello
authors.forename: Valeria
authors.initials: V
authors.lastname: Casanova Borca
authors.forename: Andrea
authors.initials: A
authors.lastname: Peruzzo Cornetto
authors.forename: Gianmauro
authors.initials: G
authors.lastname: Numico
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: La Porta
authors.forename: Santi
authors.initials: S
authors.lastname: Tofani
authors.forename: Umberto
authors.initials: U
authors.lastname: Ricardi
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D011881:Radiotherapy, Computer-Assisted / Q000009:adverse effects; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D016896:Treatment Outcome