title: EVpedia: A community web resource for prokaryotic and eukaryotic extracellular vesicles research.
abstract: For cell-to-cell communication, all living cells including archaea, bacteria, and eukaryotes secrete nano-sized membrane vesicles into the extracellular space. These extracellular vesicles harbor specific subsets of proteins, mRNAs, miRNAs, lipids, and metabolites that represent their cellular status. These vesicle-specific cargos are considered as novel diagnostic biomarkers as well as therapeutic targets. With the advancement in high-throughput technologies on multiomics studies and improvements in bioinformatics approaches, a huge number of vesicular proteins, mRNAs, miRNAs, lipids, and metabolites have been identified, and our understanding of these complex extracellular organelles has considerably increased during these past years. In this review, we highlight EVpedia (http://evpedia.info), a community web portal for systematic analyses of prokaryotic and eukaryotic extracellular vesicles research.
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
authors.forename: Dae-Kyum
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
authors.forename: Jaewook
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Simpson
authors.affiliation: Krefting Research Centre, Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg 405 30, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Lötvall
authors.affiliation: Department of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea. Electronic address: ysgho@postech.ac.kr.
authors.forename: Yong Song
authors.initials: YS
authors.lastname: Gho
mesh_terms: D035843:Biomedical Research; D056890:Eukaryota / Q000166:cytology* / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000737:chemistry* / Q000378:metabolism; D016247:Information Storage and Retrieval; D020407:Internet; D011387:Prokaryotic Cells / Q000166:cytology* / Q000378:metabolism
keywords: Communicasomes; Ectosomes; Exosomes; Microvesicles; Nanocosmos; Outer membrane vesicles