title: The return of the prodigal son and the extraordinary development route of antibody TGN1412 - lessons for drug development and clinical pharmacology.
authors.affiliation: The Netherlands Organisation for Health Research and Development (ZonMw).
authors.forename: Marcel J H
authors.initials: MJ
authors.lastname: Kenter
authors.forename: Adam F
authors.initials: AF
authors.lastname: Cohen
mesh_terms: D000818:Animals; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D018106:CD28 Antigens / Q000276:immunology; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D057239:Early Termination of Clinical Trials; D006801:Humans; D008252:Macaca fascicularis; D010601:Pharmacology, Clinical / Q000379:methods*; D013045:Species Specificity
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018106:CD28 Antigens; C509303:TGN-1412