title: Study of correlation between state and composition of lipid phase and change in erythrocytes structure under induction of oxidative processes.
abstract: We investigated human blood erythrocytes under oxidative stress in vitro and established a correlation between composition and state of lipids and changes in erythrocytes structure under induced oxidative stress. These changes may serve as an indicator of not only the erythrocyte state but of systemic processes that occur at the level of the whole organism, including various pathologies as well. We found that a pyrimidine derivative xymedon used in the present study is an effective inhibitor of oxidative processes. Xymedon may be useful as an antioxidant for preserving the structural and functional characteristics of the erythrocytes in the treatment of organisms exposed to physical and toxic factors causing oxidative stress.
authors.affiliation: Department of Biotechnology, Bioengineering and Biochemistry, Faculty of Biotechnology and Biology, Ogarev Mordovia State University, 68, Bolshevistskaya Street, Saransk, Republic of Mordovia, 430005, Russia.
authors.forename: Viktor V
authors.initials: VV
authors.lastname: Revin
authors.forename: Svetlana M
authors.initials: SM
authors.lastname: Filatova
authors.forename: Ilya V
authors.initials: IV
authors.lastname: Syusin
authors.forename: Marina Yu
authors.initials: MY
authors.lastname: Yazykova
authors.forename: Elvira S
authors.initials: ES
authors.lastname: Revina
authors.forename: Natalia V
authors.initials: NV
authors.lastname: Gromova
authors.forename: Arkadiy A
authors.initials: AA
authors.lastname: Devyatkin
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D048430:Cell Shape / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D011743:Pyrimidines / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D010743:Phospholipids; D011743:Pyrimidines; C069705:xymedon