title: Cerebral sinus venous thrombosis: clinical and pathogenetic perspectives from Tuscany.
abstract: Cerebral sinus venous thrombosis (CSVT) is a rare condition representing the 0.5-1% of all stroke cases which can have serious consequences. Early diagnosis and complete screening for acquired or inherited risk factors is crucial for decreasing morbidity and mortality. We have investigated clinical and aetiological factors in an Italian cohort of 43 patients with cerebral sinus venous thrombosis. Common presentation complaints were headache (81.4%), focal signs (20.9%), vomiting (11.6%) and seizures (6.9%). Acquired or inherited conditions were observed in more than 80% of cases. The commonest aetiological factors were contraceptives (74.1% of women), congenital thrombophilia (34.9%), infections and dysthyroidism (16.3%), hyperhomocysteinemia (9.3%), migraine (11.6%), cranial trauma (9.3%) and chronic myeloproliferative diseases (11.6%). Outcome was favourable in more than 80% of patients. Early diagnosis and anticoagulant treatment may decrease mortality and/or morbidity rates related with CVST in these patients. Thrombophilic abnormalities, either inherited or acquired, are worthy to be widely investigated.
authors.affiliation: Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Terni
authors.forename: Nicola
authors.initials: N
authors.lastname: Giannini
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiti
authors.forename: Gino
authors.initials: G
authors.lastname: Gialdini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Orlandi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Montano
authors.forename: Daniele
authors.initials: D
authors.lastname: Orsucci
authors.forename: Marco
authors.initials: M
authors.lastname: Brondi
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000473:pathology*; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult