title: Membranous nephropathy presenting with nephrotic syndrome in a child with thalassemia major.
abstract: Few data on the renal effects of thalassemia syndrome are available in the literature. Recent clinical studies identified proximal tubular damage and glomerular filtration abnormalities in thalassemia. Iron-chelating agents might be nephrotoxic as well, but proven glomerular injury, either due to anemia or chelating therapy, has not previously been demonstrated in thalassemia patients. Here, we report the first thalassemia patient presenting with nephrotic syndrome to be diagnosed with membranous nephropathy in the literature.
authors.affiliation: Division of Pediatric Nephrology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Sevgi
authors.initials: S
authors.lastname: Yavuz
authors.affiliation: Division of Pediatric Nephrology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Anarat
authors.affiliation: Division of Pediatric Nephrology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Aysun Karabay
authors.initials: AK
authors.lastname: Bayazıt
authors.affiliation: Division of Pediatric Haematology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Barbaros Şahin
authors.initials: BŞ
authors.lastname: Karagun
authors.affiliation: Division of Pediatric Haematology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Sema
authors.initials: S
authors.lastname: Yılmaz
authors.affiliation: Division of Pediatric Haematology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Yurdanur
authors.initials: Y
authors.lastname: Kılınc
authors.affiliation: Division of Pathology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Gulfiliz
authors.initials: G
authors.lastname: Gonlusen
authors.affiliation: Histology and Embryology, Cukurova University School of Medicine, Adana, Turkey.
authors.forename: Yurdun
authors.initials: Y
authors.lastname: Kuyucu
mesh_terms: D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005919:Glomerular Filtration Rate; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008856:Microscopy, Fluorescence; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology*; D017086:beta-Thalassemia / Q000150:complications* / Q000175:diagnosis
keywords: iron chelator; membranous nephropathy; nephrotic syndrome; proteinuria; thalassemia