title: Solvent/detergent-treated plasma: a tale of 30 years of experience.
abstract: Solvent/detergent-treated plasma was licensed >30 years ago. It has several specific characteristics, the most important being the standardized content of clotting factors, the lack of antibodies implicated in transfusion-related acute lung injury pathogenesis and the very high level of safety against transfusion-related viral infections. Since 1992, many clinical studies have confirmed its safety and efficacy in a wide range of congenital and acquired bleeding disorders. After a brief analysis of the pharmaceutical characteristics of solvent/detergent plasma, this review will focus on the clinical experience with this virus-inactivated plasma.
authors.affiliation: Hospital "San Giovanni Calibita" Fatebenefratelli, UOC Immunohematology and Transfusion Medicine, Piazza Fatebenefratelli, 2, Rome, Italy.
authors.forename: Giancarlo Maria
authors.initials: GM
authors.lastname: Liumbruno
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Marano
authors.forename: Gioia
authors.initials: G
authors.lastname: Grazzini
authors.forename: Enrico
authors.initials: E
authors.lastname: Capuzzo
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis / Q000378:metabolism; D016913:Blood Component Transfusion; D058731:Blood Safety / Q000379:methods*; D001803:Blood Transfusion; D003902:Detergents / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D010949:Plasma / Q000737:chemistry / Q000378:metabolism / Q000821:virology*; D012997:Solvents / Q000737:chemistry* / Q000302:isolation & purification; D013242:Sterilization / Q000379:methods*; D014777:Virus Diseases / Q000517:prevention & control; D014780:Viruses / Q000302:isolation & purification
chemical_list: D001779:Blood Coagulation Factors; D003902:Detergents; D012997:Solvents
keywords: clinical efficacy; fresh frozen plasma; solvent/detergent plasma; transfusion-related acute lung injury; virus inactivation