title: Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression.
abstract: Epithelial-mesenchymal transition (EMT) is a highly conserved process defined by the loss of epithelial characteristics, and acquisition of the mesenchymal phenotype. In addition to its central role in development, EMT has been implicated as a cellular process during tumourigenesis which facilitates tumour cell invasion and metastasis. The EMT process has been largely defined by signal transduction networks and transcriptional factors that activate mesenchymal-associated gene expression. Knowledge of secretome components that influence EMT including secreted proteins/peptides and membrane-derived extracellular vesicles (EVs) (i.e., exosomes) has emerged. Here we review EV cargo associated with inducing the hallmarks of EMT and cancer progression, modulators of cell transformation, invasion/migration, angiogenesis, and components involved in establishing the metastatic niche.
authors.affiliation: La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Greening
authors.affiliation: La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia.
authors.forename: Shashi K
authors.initials: SK
authors.lastname: Gopal
authors.affiliation: La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia.
authors.forename: Rommel A
authors.initials: RA
authors.lastname: Mathias
authors.affiliation: Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Sheng
authors.affiliation: Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria 3050, Australia.
authors.forename: Hong-Jian
authors.initials: HJ
authors.lastname: Zhu
authors.affiliation: La Trobe Institute for Molecular Science (LIMS), La Trobe University, Bundoora, Victoria 3086, Australia. Electronic address: Richard.simpson@latrobe.edu.au.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Simpson
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D058750:Epithelial-Mesenchymal Transition; D055354:Exosomes / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*
keywords: Cancer progression; EMT; Epithelial–mesenchymal transition; Exosomes; Extracellular vesicles; Microparticles