title: Discriminative-stimulus effects of second generation synthetic cathinones in methamphetamine-trained rats.
abstract: BACKGROUND
  Synthetic cathinones are beta-ketophenethylamine analogs manufactured to avoid legal restrictions placed on illicit stimulants like methamphetamine. Regulating these "emerging" designer drugs require scientific evidence of abuse potential.
  
  
  METHODS
  The present study evaluated the discriminative-stimulus effects of three synthetic cathinones, recently identified in commercial and confiscated products, in male Sprague-Dawley rats trained to discriminate methamphetamine (1.0 mg/kg) from saline under a fixed-ratio (FR) 20 schedule of food delivery. Three synthetic cathinones, 4-methyl-N-ethylcathinone (4-MEC; 1.0-8.0 mg/kg), 4-methyl-alpha-pyrrolidinopropiophenone (4-MePPP; 4.0-16.0 mg/kg), and alpha-pyrrolidinopentiophenone (alpha-PVP; 0.25-2.0 mg/kg) were tested for their ability to substitute for methamphetamine.
  
  
  RESULTS
  Full substitution for the training dose of methamphetamine occurred at the highest doses for both 4-MePPP and alpha-PVP, and 4-MEC did not substitute at any dose tested.
  
  
  CONCLUSIONS
  The present findings show that two synthetic cathinones, 4-MePPP and alpha-PVP, produced subjective effects similar to those of methamphetamine. The synthetic cathinone, 4-MEC, did not produce subjective effects similar to those of methamphetamine with the parameters used in the current experiment. Based on findings here and by others, these three compounds warrant further tests of abuse potential.
authors.affiliation: Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, United States. Electronic address: jnaylor@umc.edu.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Naylor
authors.affiliation: Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Freeman
authors.affiliation: Center for Drug Discovery, Research Triangle Institute, Research Triangle Park, NC 27709, United States.
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Blough
authors.affiliation: Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: William L
authors.initials: WL
authors.lastname: Woolverton
authors.affiliation: Division of Neurobiology and Behavior Research, Department of Psychiatry and Human Behavior, The University of Mississippi Medical Center, Jackson, MS 39216, United States.
authors.forename: Sally L
authors.initials: SL
authors.lastname: Huskinson
mesh_terms: D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D015198:Designer Drugs / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D012646:Self Administration
chemical_list: C461487:4'-methyl-alpha-pyrrolidinopropiophenone; D000662:Amphetamines; D000697:Central Nervous System Stimulants; D015198:Designer Drugs; D011427:Propiophenones; D011758:Pyrroles; D011759:Pyrrolidines; C487966:alpha-pyrrolidinopropiophenone; D008694:Methamphetamine; C585202:4-methylethcathinone
keywords: Drug discrimination; Methamphetamine; Synthetic cathinones