title: Acetylsalicylic acid does not alter thermo-effector responses during mild whole-body passive heat stress in young men.
abstract: Acetylsalicylic acid (ASA), aspirin, exerts potent systemic effects that may interfere with normal thermo-effector responses. We investigated the influence of commonly ingested ASA doses on measures of skin blood flow (SkBF) and local sweat rate (SR) during whole-body, passive heat stress. Seven male participants completed counter-balanced trials to compare ASA treatments (single dose 325 mg or 4 consecutive days 81 mg (4-d 81 mg)) to control (no ASA). Laser-Doppler flowmetry provided an index of SkBF. A ventilated capsule measured local sweat rate via capacitance hygrometry. Mean body temperature ([Formula: see text]) was increased by 1 °C above baseline using a water-perfused suit. [Formula: see text] was similar at the onset of cutaneous vasodilation among trials. Cutaneous vascular conductance, expressed as a percentage change from baseline, was not different among trials. Additionally, [Formula: see text] at the onset of local SR and SR sensitivity did not differ among trials. While ASA has previously been shown to influence SkBF during heat stress, it is possible our cohort's relatively young age may have contributed to our dissimilar results.
authors.affiliation: Department of Kinesiology, University of Alabama , Tuscaloosa , Alabama .
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Carter
authors.forename: Robert L
authors.initials: RL
authors.lastname: Herron
authors.forename: S Zeb
authors.initials: SZ
authors.lastname: Akers
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Bishop
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D018882:Heat Stress Disorders / Q000188:drug therapy* / Q000503:physiopathology; D006358:Hot Temperature; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects* / Q000502:physiology; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects*; D013546:Sweating / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin; cyclooxygenase; sweating; thermoregulation; vasodilation