title: Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes.
abstract: OBJECTIVE
  To compare the lesion characteristics of two different types of confocal scanning laser ophthalmoscopy (cSLO) autofluorescence (AF) images in central serous chorioretinopathy (CSC).
  
  
  METHODS
  The study included 63 eyes of 61 patients; 63 pairs of fundus autofluorescence (FAF) images were compared before CSC resolution in 63 eyes, FAF images of 31 eyes were also compared after CSC resolution. The lesion characteristics (brightness and composite pattern) were compared between Heidelberg Retina Angiograph 2 (HRA2; Heidelberg Engineering, Germany) and Optomap Tx (Optomap; Optos, Scotland) FAF images. The lesion composite pattern was categorized as diffuse or granular. Diffuse AF was defined as homogenously increased or decreased AF, and granular AF was defined as dot-like, coarse changes in AF. The mean disease duration and subretinal fluid (SRF) height in the spectral domain optical coherence tomography were compared according to the FAF image characteristics.
  
  
  RESULTS
  Lesion brightness before CSC resolution was hypo-AF in 48 eyes (76.2 %), hyper-AF in three (4.8 %), and mixed-AF in 12 (19.0 %) in HRA2 FAF images. In comparison, nine (14.3 %) images were hypo-AF, 44 (69.8 %) were hyper-AF, and 10 (15.9 %) were mixed-AF in Optomap FAF images (P < 0.0001). There was no significant difference in lesion composite pattern between the two FAF image wavelengths. Patients with lesions that were hyper-AF in Optomap FAF and hypo-AF in HRA2 FAF had a shorter disease duration and greater SRF height (1 month, 281 um) than those who were hyper-AF in both Optomap and HRA2 images (26 months, 153 um; P = 0.004, 0.001).
  
  
  CONCLUSIONS
  The two types of FAF images of CSC showed different lesion brightness before and after CSC resolution but demonstrated similar lesion composite patterns.
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Nam
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.
authors.forename: Cheol Min
authors.initials: CM
authors.lastname: Yun
authors.affiliation: Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Jee Taek
authors.initials: JT
authors.lastname: Kim
authors.affiliation: Department of Biostatistics, Korea niversity College of Medicine, Seoul, Korea.
authors.forename: Kyung-Sook
authors.initials: KS
authors.lastname: Yang
authors.affiliation: Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea. ksw64723@korea.ac.kr.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.
authors.forename: Jaeryung
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.
authors.forename: Kuhl
authors.initials: K
authors.lastname: Huh
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000628:therapy; D004396:Coloring Agents / Q000008:administration & dosage; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage; D017075:Laser Coagulation; D008268:Macular Degeneration; D008297:Male; D008875:Middle Aged; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy; D061848:Optical Imaging; D010778:Photochemotherapy; D055213:Retinal Pigment Epithelium; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green
keywords: Central serous chorioretinopathy; Confocal scanning laser ophthalmoscopy; Fundus autofluorescence; Heidelberg Retina Angiograph; Optomap