title: Diffusion-weighted MRI for uveal melanoma liver metastasis detection.
abstract: OBJECTIVE
  We aimed to assess the sensitivity of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of pathologically confirmed uveal melanoma liver metastases (UMLM).
  
  
  METHODS
  Twenty patients who underwent complete surgical resection of their UMLM (N = 83) were included. Pre-surgery liver MR imaging included T2-weighted, T1-weighted, DW and dynamic-gadolinium-enhanced MR sequences. Two radiologists independently reviewed three sets of images (DW / morphologic-dynamic / combined) for each patient using intraoperative and pathological findings as a standard of reference.
  
  
  RESULTS
  The sensitivities of the morphologic-dynamic and DW images for UMLM detection were 63 % and 59 %, respectively, for reader #1 (R1) and 64 % and 53 %, for reader #2 (R2). Sensitivity of the combined set was higher than sensitivity in the two other sets (R1:69 %, R2:67 %), but was only significantly different than the sensitivity of the DW images (McNemar test). For the three sets and the two readers, the sensitivity for UMLM smaller than 5 mm (37-46 %) was significantly lower than that for UMLM larger than 5 mm (67-90 %). The sensitivity for UMLM located in the subcapsular area (41-54 %) was significantly lower than that for intraparenchymal UMLM (68-86 %) (Chi-square test).
  
  
  CONCLUSIONS
  Our study shows that the addition of DW imaging to morphologic-dynamic images does not significantly increase MR sensitivities for UMLM detection.
  
  
  CONCLUSIONS
  • The MR imaging sensitivity for uveal melanoma liver metastases (UMLM) was 69 %. • Addition of DW imaging to morphologic-dynamic images does not increase sensitivity significantly. • Sensitivity for subcapsular UMLM was significantly lower than sensitivity for intraparenchymal UMLM. • The T2 shortening effect does not appear to influence lesion detection in DWI.
authors.affiliation: Department of Radiology and Nuclear Medicine, Institut Curie, 26 rue d'Ulm, 75005, Paris, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Wagner
authors.forename: Pascale
authors.initials: P
authors.lastname: Mariani
authors.forename: François Clément
authors.initials: FC
authors.lastname: Bidard
authors.forename: Manuel Jorge
authors.initials: MJ
authors.lastname: Rodrigues
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Farkhondeh
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cassoux
authors.forename: Sophie
authors.initials: S
authors.lastname: Piperno-Neumann
authors.forename: Slavomir
authors.initials: S
authors.lastname: Petras
authors.forename: Vincent
authors.initials: V
authors.lastname: Servois
mesh_terms: D000368:Aged; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D005682:Gadolinium; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000556:secondary* / Q000601:surgery; D000098943:Uveal Melanoma
chemical_list: D003287:Contrast Media; D005682:Gadolinium