title: Corneal plaque containing levofloxacin in a dog.
abstract: A 13-year-old castrated male Yorkshire terrier developed a corneal ulcer 2 weeks after intracapsular lens extraction (ICLE) in the right eye. The corneal ulcer was treated with levofloxacin eye drops. A plaque with a white luster developed in the central cornea 2 weeks after treatment with levofloxacin eye drops. The corneal plaque was surgically removed under inhalant anesthesia. The corneal plaque displayed antimicrobial activity against Escherichia coli. Furthermore, levofloxacin content in the plaque was confirmed by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight (MALDI-TOF/TOF) mass spectrometry (MS). The corneal ulcer completely resolved 2 weeks after the surgical removal of the corneal lesion and replacement of levofloxacin eye drops with tobramycin eye drops. Although the topical use of levofloxacin is unlikely to lead to corneal chemical deposits due to the high water solubility of the drug compared to other topical fluoroquinolones, this patient developed corneal plaque of the antibiotic drop.
authors.affiliation: Daegu Animal Medical Center, 36, Dongdaegu-ro, Suseong-gu, Daegu, 706-842, Korea.
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Park
authors.affiliation: Daegu Animal Medical Center, 36, Dongdaegu-ro, Suseong-gu, Daegu, 706-842, Korea.
authors.forename: Byung-Jae
authors.initials: BJ
authors.lastname: Kang
authors.affiliation: Daegu Animal Medical Center, 36, Dongdaegu-ro, Suseong-gu, Daegu, 706-842, Korea.
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Lim
authors.affiliation: Incheon Technopark Bio Center, 12, Gaetbeol-ro, Yeonsu-gu, Incheon, 406-740, Korea.
authors.forename: Jung-Mo
authors.initials: JM
authors.lastname: Ahn
authors.affiliation: Daegu Metropolitan City Institute of Health and Environment, 215, Muhak-ro, Suseong-gu, Daegu, 706-841, Korea.
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Lim
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000032:analysis / Q000627:therapeutic use; D003315:Cornea / Q000737:chemistry; D003316:Corneal Diseases / Q000139:chemically induced / Q000662:veterinary*; D003320:Corneal Ulcer / Q000188:drug therapy / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D064704:Levofloxacin / Q000009:adverse effects* / Q000032:analysis / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin
keywords: ICLE; MALDI-TOF/TOF MS; antimicrobial activity; corneal plaque; fluoroquinolones; levofloxacin