title: The role of apolipoprotein (a) in pathogenesis and clinical course of deep venous thrombosis.
abstract: Deep venous thrombosis is widespread disease, which complications, like: pulmonary embolism and postphlebitis syndrome areimportant social problem. There are many well-known and accurately described risk factors, though in many cases etiology remains unexplained. Further research into causes of deep venous thrombosis seem to be fully justified. The aim of the study was the evaluation of the influence of apolipoprotein (a) serum level in patients with deep venous thrombosis and the changes of its concentration during the treatment.
  
  
  METHODS
  26 patients with newly diagnosed deep venous thrombosis (DVT) were enrolled to the study. Diagnosis of DVT was established by use of physical examination and duplex Doppler. Measurements of apolipoprotein (a) and D-dimers serum level were recorded on the following days, starting from the day of the initial diagnosis: 1, 7, 14 and 84.
  
  
  RESULTS
  Statistically significant increase of the level of serum apolipoprotein (a) has been found during properly conducted treatment.
  
  
  CONCLUSIONS
  Alterations of the concentration of serum apoliprotein (a) during the deep venous thrombosis treatment, indicates the involvement of apolipoprotein (a) in pathogenesis of deep venous thrombosis.
authors.forename: Marek
authors.initials: M
authors.lastname: Chrapko
authors.forename: Adam
authors.initials: A
authors.lastname: Skwarzyński
authors.forename: Wacław
authors.initials: W
authors.lastname: Karakuła
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zubilewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053241:Apoprotein(a) / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D053241:Apoprotein(a)