title: Transient abnormal myelopoiesis in non-Down syndrome neonate.
abstract: We encountered a case of neonatal acute megakaryoblastic leukemia not associated with Down syndrome (DS). Molecular cytogenetic analysis of leukemic blast cells indicated that increased blast cell status was caused by transient abnormal myelopoiesis with trisomy 21 and GATA1 mutation. Based on these molecular cytogenetic data, intensive chemotherapy was avoided, and the patient was successfully cured with low-dose cytarabine. Morphologically, leukemic blast cells of acute megakaryoblastic leukemia in a non-DS neonate are indistinguishable from a blast cell of transient abnormal myelopoiesis. The possibility of transient abnormal myelopoiesis should be carefully considered before intensive chemotherapy is adopted.
authors.affiliation: Department of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Teppei
authors.initials: T
authors.lastname: Ohkawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Sugie
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tomizawa
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Imai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Nagasawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morio
authors.forename: Shuki
authors.initials: S
authors.lastname: Mizutani
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takagi
mesh_terms: D015153:Blotting, Western; D004247:DNA / Q000235:genetics*; D004314:Down Syndrome / Q000235:genetics* / Q000378:metabolism; D050982:GATA1 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007955:Leukemoid Reaction / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; D004247:DNA
keywords: Down syndrome; GATA1; acute megakaryoblastic leukemia; neonate; transient abnormal myelopoiesis