title: The incidental relationship between serum ferritin levels and hypertension.
abstract: OBJECTIVE
  Although several studies have shown an association between ferritin level and hypertension, only a few studies have investigated the longitudinal relationship between them. Thus, we evaluated the incidental risk for hypertension according to baseline ferritin level.
  
  
  METHODS
  A total of 7104 healthy Korean men matched by a propensity score, who had participated in a medical health check-up program in 2005, were followed up from 2005 to 2010. They were divided into four groups according to baseline serum ferritin level (first quartile-fourth quartile). The incidence of hypertension was compared among the four groups, and the Cox-proportional hazard model was used to assess whether the development of hypertension was associated with higher baseline serum ferritin level.
  
  
  RESULTS
  A total of 1252 (17.6%) cases had newly developed hypertension during the 26,339.5 person-years of follow-up between 2006 and 2010. The adjusted hazard ratios (HRs) (95% confidence intervals, CIs) for incident hypertension were 1.00 (reference), 1.09 (0.91-1.30), 1.21 (1.01-1.45) and 1.28 (1.07-1.52), respectively (P for trend=0.003) through the quartiles of serum ferritin levels, respectively, after adjusting for multiple confounders. For the log-transformed serum ferritin levels as a continuous variable, adjusted HRs and 95% CIs for HTN were 1.15 (1.02-1.29).
  
  
  CONCLUSIONS
  Elevated serum ferritin level was independently associated with the incidental risk for hypertension in Korean men. This finding suggests the value of elevated ferritin level as an early predictor of hypertension.
authors.affiliation: Departments of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Sun Yong
authors.initials: SY
authors.lastname: Kim
authors.affiliation: Korea Central Cancer Registry, National Cancer Control Institute, National Cancer Center, Goyang, Republic of Korea.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Oh
authors.affiliation: Departments of Preventive Medicine, Kyung Hee University School of Medicine, Seoul, Republic of Korea; Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. Electronic address: kkkmin7@hotmail.com.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, Seoul, Republic of Korea.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, Seoul, Republic of Korea.
authors.forename: Se-Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Medical Management, Graduate School, Gachon University, Incheon, Republic of Korea.
authors.forename: Jae
authors.initials: J
authors.lastname: In Yu
authors.affiliation: Department of Occupational and Environmental Medicine, Dongguk University, Gyeongju Hospital, Gyeongsangbuk-do, Republic of Korea.
authors.forename: Min-Gi
authors.initials: MG
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Republic of Korea.
authors.forename: Yong-Sung
authors.initials: YS
authors.lastname: Choi
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, Seoul, Republic of Korea.
authors.forename: Taeg Su
authors.initials: TS
authors.lastname: Ko
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005293:Ferritins / Q000097:blood*; D006432:Hemochromatosis / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology
chemical_list: D005293:Ferritins
keywords: Ferritin; Hypertension