title: Coronaviruses: an overview of their replication and pathogenesis.
abstract: Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are characterized by club-like spikes that project from their surface, an unusually large RNA genome, and a unique replication strategy. Coronaviruses cause a variety of diseases in mammals and birds ranging from enteritis in cows and pigs and upper respiratory disease in chickens to potentially lethal human respiratory infections. Here we provide a brief introduction to coronaviruses discussing their replication and pathogenicity, and current prevention and treatment strategies. We also discuss the outbreaks of the highly pathogenic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and the recently identified Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
authors.affiliation: Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Fehr
authors.forename: Stanley
authors.initials: S
authors.lastname: Perlman
mesh_terms: D000818:Animals; D017934:Coronavirus / Q000502:physiology*; D018352:Coronavirus Infections / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D015870:Gene Expression; D016679:Genome, Viral; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D053585:Virus Attachment; D057074:Virus Release; D014779:Virus Replication
chemical_list: D014764:Viral Proteins