title: Baseline circulating ghrelin does not predict weight regain neither maintenance of weight loss after gastric bypass at long term.
abstract: BACKGROUND
  Predictors of weight loss (WL) or weight regain (WR) after Roux-en-Y gastric bypass (RYGBP) are not established. The aim of this study was to analyze the usefulness of some baseline peptides (leptin, insulin, and ghrelin) as biomarkers of WL and WR in morbid obese patients after RYGBP at long term.
  
  
  METHODS
  Seventy-six morbid obese (47 women, age 41.6 ± 9.6 years, body mass index [BMI] 52.1 ± 8 kg/m(2)) patients were evaluated at baseline and at 1, 2, and 6 years after surgery.
  
  
  RESULTS
  Excess body weight loss after 6 years was of 63.9%. Age, BMI, and studied hormones at baseline or their changes over time did not predict long-term excess body weight loss. WR greater than 10% was observed in 36.8% of patients between 2 and 6 years of follow-up, but it was not correlated with BMI, age, or baseline peptide concentrations.
  
  
  CONCLUSIONS
  Measurement of ghrelin, insulin, and leptin before surgery is not useful as predictors of WL or WR at long term after RYGBP.
authors.affiliation: Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain. Electronic address: spellitero.germanstrias@gencat.cat.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pellitero
authors.affiliation: Surgery Department, Mutua Terrassa Hospital, Terrassa, Barcelona, Spain.
authors.forename: Noelia
authors.initials: N
authors.lastname: Pérez-Romero
authors.affiliation: Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Martínez
authors.affiliation: Clinical Biochemistry Service, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: María L
authors.initials: ML
authors.lastname: Granada
authors.affiliation: Surgery Department, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Moreno
authors.affiliation: Surgery Department, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Balibrea
authors.affiliation: Surgery Department, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Tarascó
authors.affiliation: Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Anna
authors.initials: A
authors.lastname: Lucas
authors.affiliation: Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research Institute and University Hospital, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Puig-Domingo
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D013997:Time Factors; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D054439:Ghrelin; D007328:Insulin; D020738:Leptin
keywords: Gastric bypass; Ghrelin; Leptin; Weight regain