title: The medical and laser management of hidradenitis suppurativa.
abstract: Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease characterized by painful recurrent nodules and abscesses. In advanced stages, sinus tracts form, with resulting fibrotic and cribriform scar formation, leading to dermal contractures and induration of the affected skin. The epidemiology of HS is poorly described, and few population-based studies exist. The reported incidence varies from 0.0003 to 4%. Effective treatment options for HS are limited, and randomized controlled trials addressing the safety and/or efficacy of available treatments are scarce. No medical treatment to date has been approved by the US FDA specifically for the treatment of HS. While some evidence of disease improvement exists with agents including clindamycin and rifampicin, metformin, fumarates, infliximab, and adalimumab, no single treatment has shown overwhelmingly positive outcomes. The lack of randomized controlled trials for most treatments and often disappointing treatment outcomes is disheartening. This study reviews the published evidence for treatment options for HS.
authors.affiliation: Department of Dermatology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland, rossiehughes@gmail.com.
authors.forename: Rosalind
authors.initials: R
authors.lastname: Hughes
authors.forename: Genevieve
authors.initials: G
authors.lastname: Kelly
authors.forename: Cheryl
authors.initials: C
authors.lastname: Sweeny
authors.forename: Aoife
authors.initials: A
authors.lastname: Lally
authors.forename: Brian
authors.initials: B
authors.lastname: Kirby
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001691:Biological Therapy / Q000379:methods; D017497:Hidradenitis Suppurativa / Q000382:microbiology / Q000628:therapy*; D020249:Hormone Replacement Therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D053685:Laser Therapy / Q000379:methods*
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents