title: Low frequency mutations independently predict poor treatment-free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.
authors.affiliation: Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, UK Klinik für Innere Medizin II, Universitätsklinikum Jena, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Winkelmann
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Rose-Zerilli
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Jade
authors.initials: J
authors.lastname: Forster
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Marina
authors.initials: M
authors.lastname: Parry
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
authors.forename: Anton
authors.initials: A
authors.lastname: Parker
authors.affiliation: Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Gardiner
authors.affiliation: Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
authors.forename: Zadie
authors.initials: Z
authors.lastname: Davies
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Steele
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK.
authors.forename: Helen
authors.initials: H
authors.lastname: Parker
authors.affiliation: Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, UK Human Development and Health, Faculty of Medicine, University of Southampton, UK.
authors.forename: Nicholas C P
authors.initials: NC
authors.lastname: Cross
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK Department of Molecular Pathology, Royal Bournemouth Hospital, Bournemouth, UK.
authors.forename: David G
authors.initials: DG
authors.lastname: Oscier
authors.affiliation: Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, UK JCS@soton.ac.uk.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Strefford
mesh_terms: D000368:Aged; D001402:B-Lymphocytes / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D008218:Lymphocytosis / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D008297:Male; D009154:Mutation / Q000235:genetics*; D011237:Predictive Value of Tests; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
keywords: early stage chronic lymphocytic leukemia; low frequency mutations; monoclonal B-cell lymphocytosis; treatment-free survival