title: [Proinflammatory cytokine levels depending on the stage of hepatic fibrosis in patients with metabolic syndrome and non-alcoholic fatty liver disease].
abstract: OBJECTIVE
  To study levels of systemic inflammation markers and plasminogen activator inhibitor-1 (PAL-1) in patients with metabolic syndrome (MS) and establish their relationship with the progress of selected stages of non-alcoholic fatty liver disease (NAFLD).
  
  
  METHODS
  129 patients aged 18-59 yr with abdominal obesity and MS underwent elastometry for the assessment of the degree of fibrosis depending on concomitant metabolic disorders and measurement of proinflammatory cytokine levels.
  
  
  RESULTS
  Disorders of carbohydrate metabolism in MS patients are associated with the high levels of systemic inflammation markers (CRP, TNF-α, IL-6) and a two-fold rise in the PAI-1 level. The progress of fibrosis is associated with the increase of cytokine levels.
  
  
  CONCLUSIONS
  Patients with MS and NAFLD associated with disorders of carbohydrate metabolism need to be examined by elastometry for the detection of fibrosis with simultaneous measurement of IL-6 and PAI-1 levels as cardiovascular risk factors.
authors.forename: L V
authors.initials: LV
authors.lastname: Chesnokova
authors.forename: I M
authors.initials: IM
authors.lastname: Petrov
authors.forename: I A
authors.initials: IA
authors.lastname: Troshina
authors.forename: I V
authors.initials: IV
authors.lastname: Medvedeva
mesh_terms: D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000276:immunology*; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines