title: Anterior segment optical coherence tomography evaluation of ocular graft-versus-host disease: a case study.
abstract: To explore ocular graft-versus-host disease (GVHD), anterior segment optical coherence tomography (AS-OCT) imaging of eyelids, tear meniscus, cornea and conjunctiva is performed in subsequent sessions on a patient who has ocular GVHD after allogeneic related donor stem cell transplant. The OCT results are presented together with those from a normal subject. OCT imaging is promising in visualizing several ocular GVHD manifestations, such as abnormal meibomian gland orifice (MGO), conjunctival keratinization, conjunctival hyperemia and chemosis, corneal epithelium opacification, thinning and sloughing. This case study demonstrates the capability of AS-OCT in the imaging and monitoring of ocular GVHD, which may be useful in the development of current ocular GVHD staging system and the clinical management for GVHD treatment.
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Sun
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Sepideh
authors.initials: S
authors.lastname: Hariri
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Zhehai
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Inamoto
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Tueng T
authors.initials: TT
authors.lastname: Shen
authors.affiliation: 1 Department of Bioengineering, 2 Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA ; 3 Buddhist Tzu Chi General Hospital, Taipei Division, New Taipei, Taiwan ; 4 Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
keywords: Medical and biological imaging; ocular graft-versus-host disease (GVHD); ophthalmology; optical coherence tomography (OCT)