title: Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population.
abstract: OBJECTIVE
  To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10.
  
  
  METHODS
  Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis.
  
  
  RESULTS
  Rs35975099 was in Harvey-Weinberg equilibrium in patients with migraine (n = 269) and control subjects (n = 374). There were no significant relationships between allele or genotype frequency and migraine.
  
  
  CONCLUSIONS
  There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.
authors.affiliation: Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Jia
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Wanli
authors.initials: W
authors.lastname: Dong
authors.affiliation: Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
authors.forename: Xianju
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Neurology, Laboratory of Neurological Diseases, Changzhou No.2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China wenwei_yun@yahoo.com.
authors.forename: Wenwei
authors.initials: W
authors.lastname: Yun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*; D055815:Young Adult
chemical_list: D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human
keywords: Migraine; TNFSF10; gene polymorphisms; susceptibility