title: Laparoscopic Gastric Banding in Obese Patients with Sleep Apnea: A 3-Year Controlled Study and Follow-up After 10 Years.
abstract: BACKGROUND
  The purpose of this study was to compare the effects of intensive nutritional care (INC) and laparoscopic adjustable gastric banding (LAGB) on nocturnal non-invasive ventilation (NIV) requirement in obese patients using short-, medium-, and long-term follow-up data.
  
  
  METHODS
  This prospective randomized controlled trial included obese patients with obstructive sleep apnea (OSA) treated by NIV. Patients were randomized to the INC and LAGB groups. The primary endpoint was the theoretical rate of weaning from NIV at years 1 and 3. Data were also collected from patients 10 years after randomization.
  
  
  RESULTS
  Sixty-three patients were randomized. The rate of weaning from NIV did not differ significantly between the LAGB and INC groups at year 1 (35 vs. 13%) or year 3 (14 vs. 21%). Percentages of excess weight loss were greater in the LAGB group than in the INC group at years 1 (33 vs. 15%, p = 0.002) and 3 (27 vs. 8%, p = 0.014). Decreases in the apnea-hypopnea index were observed in the LAGB group from baseline to year 1 (-44%, p = 0.001) and from baseline to year 3 (-26%, p = 0.044). After 10 years, the weaning rate was low and similar between groups.
  
  
  CONCLUSIONS
  LAGB was not superior to INC for weaning from NIV at 1 and 3 years in obese patients with OSA.
authors.affiliation: Endocrinology and Nutrition Department, University Hospital Center of Nantes, 44093, Nantes Cedex, France, barbara.feigelguiller@gmail.com.
authors.forename: Barbara
authors.initials: B
authors.lastname: Feigel-Guiller
authors.forename: Delphine
authors.initials: D
authors.lastname: Drui
authors.forename: Jérôme
authors.initials: J
authors.lastname: Dimet
authors.forename: Yassine
authors.initials: Y
authors.lastname: Zair
authors.forename: Maëlle
authors.initials: M
authors.lastname: Le Bras
authors.forename: Nuria
authors.initials: N
authors.lastname: Fuertes-Zamorano
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cariou
authors.forename: Eric
authors.initials: E
authors.lastname: Letessier
authors.forename: Estelle
authors.initials: E
authors.lastname: Nobécourt-Dupuy
authors.forename: Michel
authors.initials: M
authors.lastname: Krempf
mesh_terms: D000328:Adult; D031204:Caloric Restriction / Q000009:adverse effects / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D015391:Gastroplasty / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D063087:Noninvasive Ventilation / Q000009:adverse effects / Q000706:statistics & numerical data; D009767:Obesity, Morbid / Q000150:complications / Q000178:diet therapy* / Q000453:epidemiology / Q000601:surgery*; D010349:Patient Compliance / Q000706:statistics & numerical data; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss