title: Human papillomavirus infections in Mexican women with normal cytology, precancerous lesions, and cervical cancer: type-specific prevalence and HPV coinfections.
abstract: The prevalence and genotype distribution of human papillomavirus (HPV) provides the basis for designing HPV prevention programs. The prevalence rates of type-specific HPV and coinfections in samples of Mexican women were investigated in 822 women aged 18-87 years. HPV detection was performed using a Linear Array™ genotyping test. HPV infection was found in 12.4% of controls, 46.3% of those with cervical intraepithelial neoplasia 1, and 100% of those with cervical intraepithelial neoplasia 3 or cervical cancer. HPV 16 was the most prevalent type in all diagnosis groups. The HPV types most frequently found in cervical cancers were 16, 18, 45, 52, 58, and 39; HPV types 16, 62, 51, 84, 18, 53, and CP6108 were the most prevalent in control women. Considering HPV-positive samples only, coinfections occurred most often in controls (63%) and were less frequent in those with cervical cancer (26%). The most frequent viral types in coinfections with HPV 16 in control women were HPV 62, 51, and 84; in women with cervical cancers, HPV 18, 39, and 70 were most common. In conclusion, in addition to HPV types 16 and 18, types 45, 39, 58, 52, and 71 were found in cervical cancers in Mexican women (78%); among them, only 65% were attributable to HPV types 16 and 18. Therefore, it is necessary to consider these viral types in the design of new vaccines, and to determine whether certain HPV types coinfecting with HPV 16 in precursor lesions determine tumor progression or regression.
authors.affiliation: Western Biomedical Research Center (CIBO)-IMSS, Guadalajara, Jalisco, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Aguilar-Lemarroy
authors.forename: Verónica
authors.initials: V
authors.lastname: Vallejo-Ruiz
authors.forename: Elva I
authors.initials: EI
authors.lastname: Cortés-Gutiérrez
authors.forename: Manuel Eduardo
authors.initials: ME
authors.lastname: Salgado-Bernabé
authors.forename: Norma Patricia
authors.initials: NP
authors.lastname: Ramos-González
authors.forename: Laura
authors.initials: L
authors.lastname: Ortega-Cervantes
authors.forename: Rafael
authors.initials: R
authors.lastname: Arias-Flores
authors.forename: Irma M
authors.initials: IM
authors.lastname: Medina-Díaz
authors.forename: Fernando
authors.initials: F
authors.lastname: Hernández-Garza
authors.forename: Gerardo
authors.initials: G
authors.lastname: Santos-López
authors.forename: Patricia
authors.initials: P
authors.lastname: Piña-Sánchez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060085:Coinfection; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D017720:Molecular Epidemiology; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D011230:Precancerous Conditions / Q000821:virology*; D015995:Prevalence; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000821:virology*
keywords: Linear Array® HPV genotyping test; Mexico; cervical cancer; coinfections; human papillomavirus