title: Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques.
abstract: Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.
authors.affiliation: Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway.
authors.forename: Magnus B
authors.initials: MB
authors.lastname: Lilledahl
authors.affiliation: Linköping University, Department of Clinical Engineering, Radiation Physics, SE-581 83 Linköping, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Gustafsson
authors.affiliation: Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway.
authors.forename: Pål Gunnar
authors.initials: PG
authors.lastname: Ellingsen
authors.affiliation: Linköping University, Department of Medical and Health Sciences, SE-581 83 Linköping, Sweden.
authors.forename: Helene
authors.initials: H
authors.lastname: Zachrisson
authors.affiliation: Linköping University, Department of Clinical and Experimental Medicine, SE-581 83 Linköping, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Hallbeck
authors.affiliation: Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway.
authors.forename: Vegard Stenhjem
authors.initials: VS
authors.lastname: Hagen
authors.affiliation: Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, Norway.
authors.forename: Morten
authors.initials: M
authors.lastname: Kildemo
authors.affiliation: Norwegian University of Science and Technoogy, Department of Physics, 7491 Trondheim, NorwayeLinköping University, Department of Physics, Chemistry and Biology, SE-581 83 Linköping, Sweden.
authors.forename: Mikael
authors.initials: M
authors.lastname: Lindgren
mesh_terms: D002339:Carotid Arteries / Q000737:chemistry* / Q000473:pathology*; D002784:Cholesterol / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008853:Microscopy; D057054:Molecular Imaging; D018384:Oxidative Stress / Q000502:physiology*; D058226:Plaque, Atherosclerotic / Q000737:chemistry* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000737:chemistry
chemical_list: D017382:Reactive Oxygen Species; D002784:Cholesterol