title: Design, synthesis and in vitro bactericidal/fungicidal screening of some vanadyl(IV)complexes with mono- and di-substituted ONS donor triazoles.
abstract: A new series of anti-bacterial and anti-fungal mono- and di-substituted triazoles (L(1))-(L(6)) have been synthesized and characterized on the basis of their physical, spectral and analytical data. The ligands (L(1))-(L(6)) on reaction with vanadyl(IV) sulphate led to the formation of vanadyl(IV) metal complexes (1)-(4). The structure of the complexes has been established on the basis of their physical, spectral and elemental analyses data. The synthesized ligands and their vanadyl(IV) complexes have been screened in vitro for anti-bacterial activity against six bacterial species such as, Escherichia coli (ATCC 25922), Shigella flexneri (ATCC 12022), Pseudomonas aeruginosa (ATCC 27853), Salmonella typhi (ATCC 14028), Staphylococcus aureus (ATCC 25923) and Bacillus subtilis (ATCC 6051) and for in vitro anti-fungal activity against six fungal strains, Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata. The screening results showed the vanadyl complexes to be more bactericidal/fungicidal against one or more bacterial/fungal species. The synthesized compounds were also subjected to brine shrimp bioassay for scrutinizing their cytotoxicity.
authors.affiliation: a Department of Chemistry, Institute of Chemical Sciences and Biological Sciences , University of Gujrat , Gujrat , Pakistan .
authors.forename: Sajjad H
authors.initials: SH
authors.lastname: Sumrra
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanif
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology; D014638:Vanadates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009942:Organometallic Compounds; D014230:Triazoles; D014638:Vanadates
keywords: Anti-microbial activity; mono- and di-substituted triazoles; vanadyl(IV) complexes