title: Efficacy of valganciclovir and ganciclovir for cytomegalovirus disease in solid organ transplants: A meta-analysis.
abstract: BACKGROUND
  Cytomegalovirus (CMV), a problematic virus in solid organ transplant recipients (SOTR) such as liver, can worsen overall mortality and transplant outcome, so its prevention and treatment is a key of success in such patients. This study is aimed to compare the efficacy of ganciclovir (GCV) and valganciclovir (VGC) for prevention and treatment of infection with CMV.
  
  
  METHODS
  After sensitive and systematic search in PubMed, EMBASE, Cochrane and other available databases, both prospective and retrospective studies on effect of VGC and GCV in prevention and treatment of CMV disease among SOTR, which had our study criteria, were included. The pooled risk estimates were calculated using random-effects models.
  
  
  RESULTS
  Among 1324 title, 19 studies were included. In 11 prophylactic studies (2368 patients), the pooled risk of CMV disease (VGC relative to GCV) was 1.16, 95% confidence interval (CI): 0.91-1.49 and in studies of liver transplant recipients, 1.53, 95% CI: 0.86-2.70. Rate of viremia eradication in VGC to GCV was 1.05, 95% CI: 0.97-1.13. In 3 treatment studies (422 patients), rate of successful treatment in VGC to GCV was 0.98, 95% CI: 0.91-1.06 and viremia eradication 0.95, CI 95% 0.77-1.16. All these values did not show statistically significantly differences between GCV and VGC.
  
  
  CONCLUSIONS
  It can be concluded that VGC as an alternative to GCV can be used with equal efficacy in prevention and treatment of CMV disease in SOTR.
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Siavash
authors.initials: S
authors.lastname: Vaziri
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Zohre
authors.initials: Z
authors.lastname: Pezhman
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Sayyad
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Feizolla
authors.initials: F
authors.lastname: Mansouri
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Janbakhsh
authors.affiliation: Kermanshah Liver Disease and Hepatitis Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Afsharian
authors.affiliation: Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Najafi
keywords: Cytomegalovirus; meta-analysis; solid organs; valganciclovir