title: Impact of hepatic arterial hemodynamics in predicting early hepatic arterial thrombosis in pediatric recipients younger than three yr after living donor liver transplantation.
abstract: We used Doppler US to evaluate the changes in hepatic arterial hemodynamics that occur following LDLT in pediatric recipients, with a view to assessing the utility of these parameters in predicting early HAT. A retrospective review of 144 pediatric recipients (73 males, 71 females) who underwent routine Doppler US in the first week after LDLT was undertaken, and changes in hepatic arterial hemodynamics were assessed. The HARI and HAPSV were compared in patients with early HAT (defined as occurring in the first postoperative week) and a control group, and the utility of these parameters in predicting early HAT after LDLT was determined. A total of 11 pediatric recipients experienced early HAT, being diagnosed on average four and a half days after LDLT. HARI and HAPSV values were significantly different between the early HAT group and controls. HARI values <0.6 on the day before the onset of early HAT were able to predict HAT development with a sensitivity of 81.8% and specificity of 95.2%. This provides evidence for routine Doppler US examination in these patients and supports consideration of more intensive anticoagulation in these high-risk patients.
authors.affiliation: Department of Ultrasound, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Gu
authors.forename: Hua
authors.initials: H
authors.lastname: Fang
authors.forename: Fenghua
authors.initials: F
authors.lastname: Li
authors.forename: Shijun
authors.initials: S
authors.lastname: Zhang
authors.forename: Conghuan
authors.initials: C
authors.lastname: Shen
authors.forename: Longzhi
authors.initials: L
authors.lastname: Han
mesh_terms: D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006439:Hemodynamics; D006499:Hepatic Artery / Q000473:pathology*; D006801:Humans; D007223:Infant; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D012372:ROC Curve; D012189:Retrospective Studies; D012306:Risk; D012680:Sensitivity and Specificity; D013927:Thrombosis / Q000175:diagnosis* / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
keywords: Doppler ultrasonography; hemodynamic; hepatic artery thrombosis; living donor liver transplantation; pediatric