title: Preoperative Neutrophil-to-Lymphocyte Ratio Has a Better Predictive Capacity in Diagnosing Tubo-Ovarian Abscess.
abstract: BACKGROUND
  The aim of this study is to identify the inflammatory markers which predict a tubo-ovarian abscess (TOA) in the most accurate way.
  
  
  METHODS
  This study involves 312 women. Preoperative inflammatory markers in the study group were compared with those in the healthy control group to identify the most efficient predictor of TOA with a high sensitivity and specificity. The recommended cutoff values of the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), white blood cell count, and red cell distribution width were determined using receiver operating characteristic curve (ROC) analyses.
  
  
  RESULTS
  The area under the curve (AUC = 0.99) in the ROC analysis was found to be statistically significant for NLR (p < 0.001) with a cutoff value of ≥4.15 (95% CI 0.97-1.00, sensitivity 95.2%, specificity 99.4%). The positive predictive value of NLR was 99.2%, and the negative predictive value was 96.7% (p < 0.001). The recommended threshold for PLR was found to be 164.37 (AUC = 0.95, 95% CI 0.93-0.98, sensitivity 86.7%, specificity 92%), and the cutoff point of the white blood cell count in the ROC analysis was 9.55 × 103/μl (AUC = 0.90, 95% CI 0.87-0.95, sensitivity 78.68%, specificity 96.68%).
  
  
  CONCLUSIONS
  Preoperative NLR and PLR improve the predictive value of serum markers for the presence of TOA.
authors.affiliation: Department of Obstetrics and Gynecology at Ataturk Training and Research Hospital, Ankara, Turkey.
authors.forename: Melahat
authors.initials: M
authors.lastname: Yildirim
authors.forename: Esengul
authors.initials: E
authors.lastname: Turkyilmaz
authors.forename: Ayse Filiz
authors.initials: AF
authors.lastname: Avsar
mesh_terms: D000038:Abscess / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D009869:Oophoritis / Q000097:blood*; D011237:Predictive Value of Tests; D012488:Salpingitis / Q000097:blood*; D055815:Young Adult