title: Dispersive solid-liquid phase microextraction based on nanomagnetic Preyssler heteropolyacid: A novel method for the preconcentration of nortriptyline.
abstract: In this study, a new, simple, rapid, and efficient method combined with ultraviolet visible spectrophotometry and high-performance liquid chromatography analysis was developed for the extraction and determination of nortriptyline. The tendency of the Preyssler tungsten heteropolyacid, H14 [NaP5 W30 O110 ], immobilized on the surface of mesoporous nanomagnetite to adsorb the drug from the solution has been investigated. This method involves the use of an appropriate mixture of nanosorbent that was homogenized in disperser solvent (1.0 mL, ethanol). At first, the mixture containing the nanomagnetic sorbent and disperser solvent was injected into the aqueous sample, and a cloudy solution was formed. Subsequently, separation of the two phases was carried out using a magnet. In the second stage, analyte was desorbed from the sorbent by methanol as the optimal desorption solvent using sonication method. The elution solvent containing enriched analyte was introduced to the instruments for further analysis. Optimization of experimental conditions with respect to the extraction efficiency was investigated. The method was linear in the range of 25-5000, while the detection limit (LOD = 3SB /m) was 7.9 ng/mL and the limit of quantification (LOQ = 10SB /m) was 26.4 ng/mL. The relative standard deviation was 4.66%. The method was successfully applied to human hair samples.
authors.affiliation: Department of Chemistry, Payame Noor University, Tehran, Iran.
authors.forename: Zarrin
authors.initials: Z
authors.lastname: Es'haghi
authors.affiliation: Department of Chemistry, Payame Noor University, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Hooshmand
mesh_terms: D000143:Acids / Q000737:chemistry*; D006197:Hair / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D059627:Liquid Phase Microextraction; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D009661:Nortriptyline / Q000032:analysis / Q000302:isolation & purification*; D052617:Solid Phase Microextraction; D013056:Spectrophotometry, Ultraviolet; D014874:Water Pollutants, Chemical / Q000737:chemistry
chemical_list: D000143:Acids; D006571:Heterocyclic Compounds; D058185:Magnetite Nanoparticles; D014874:Water Pollutants, Chemical; D009661:Nortriptyline
keywords: Dispersive solid-liquid microextraction; Nanomagnetite; Nortriptyline; Preyssler heteropolyacids