title: Drug-induced skin reactions: a 2-year study.
abstract: BACKGROUND
  The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity.
  
  
  METHODS
  The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007-2009). In 84 cases, histopathologic examination of skin biopsies were also performed.
  
  
  RESULTS
  Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%).
  
  
  CONCLUSIONS
  Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
authors.affiliation: Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Farshchian
authors.affiliation: Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Ansar
authors.affiliation: Department of Dermatology, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Zamanian
authors.affiliation: Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Rahmatpour-Rokni
authors.affiliation: Derm Surgery Associates, Houston, TX, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Kimyai-Asadi
authors.affiliation: Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamedan, Iran ; Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Farshchian
keywords: acute urticaria; adverse drug reaction; exanthematous eruption