title: In-TOX-icating neurogenesis.
abstract: Early development of the mammalian cerebral cortex proceeds via a sequence of proliferative and differentiative steps from neural stem cells toward neurons and glia. However, how these steps are molecularly orchestrated is still only partially understood. In this issue of The EMBO Journal, Artegiani and colleagues implicate Tox, a HMG-box transcription factor previously known only for its role in lymphocyte development, in early cortical development.
authors.affiliation: Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Munich, Germany Laboratory "Adult Neurogenesis and Cellular Reprogramming", Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Marisa
authors.initials: M
authors.lastname: Karow
authors.affiliation: Laboratory "Adult Neurogenesis and Cellular Reprogramming", Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany Focus Program Translational Neuroscience, Johannes Gutenberg University Mainz, Mainz, Germany.
authors.forename: Benedikt
authors.identifier: http://orcid.org/0000-0003-2652-2782
authors.initials: B
authors.lastname: Berninger
mesh_terms: D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D002540:Cerebral Cortex / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism*; D050778:NFATC Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018398:Homeodomain Proteins; D050778:NFATC Transcription Factors; C493241:Rhox8 protein, mouse; D019703:Calcineurin