title: [Prefabrication of vascularized facial bones].
abstract: Critical size defects in the craniomaxillofacial region often result from ablative tumor surgery, inflammation and posttraumatic deformities. To date, autologous bone grafts are still the gold standard for the reconstruction of these defects; however, they are frequently associated with severe donor site morbidity as well as functional and aesthetic compromises. In this context various resorbable and non-resorbable bone replacement materials have been developed and intensively investigated. Particularly in critical size defects these materials fail due to their lack of osteogenic potential and endogenous vascularization. The combination of alloplastic osteoconductive scaffolds, osteogenic cells, and axial prevascularization in bioartificial bone grafts might present an innovative approach for the microsurgical reconstruction of critical size defects.
authors.affiliation: Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland, zimmerer.ruediger@mh-hannover.de.
authors.forename: R
authors.initials: R
authors.lastname: Zimmerer
authors.forename: P
authors.initials: P
authors.lastname: Jehn
authors.forename: S
authors.initials: S
authors.lastname: Spalthoff
authors.forename: H
authors.initials: H
authors.lastname: Kokemüller
authors.forename: N-C
authors.initials: NC
authors.lastname: Gellrich
mesh_terms: D021522:Bioartificial Organs; D016025:Bone Transplantation / Q000379:methods*; D005147:Facial Bones / Q000098:blood supply* / Q000601:surgery*; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D008866:Microsurgery / Q000379:methods*; D010012:Osteogenesis / Q000502:physiology; D023822:Tissue Engineering / Q000379:methods*