title: Effects of high-intensity focused ultrasound for treatment of abdominal lymph node metastasis from gastric cancer.
abstract: OBJECTIVE
  This retrospective study aimed to compare the efficacy and safety of combination treatment with high-intensity focused ultrasound (HIFU) and chemotherapy to those of chemotherapy alone for treatment of the abdominal lymph node metastasis from gastric cancer.
  
  
  METHODS
  A total of 185 patients with gastric cancer and abdominal lymph node metastasis were enrolled and divided into 2 groups: group A received chemotherapy alone (n = 102); group B received HIFU combined with chemotherapy (n = 83). The clinical efficacy and safety of the groups were then analyzed.
  
  
  RESULTS
  The overall response rates of groups A and B were 34.3% and 47.0%, respectively (P = .046). The pain relief rates in groups A and B were 51.6% and 75.0% (P = .039). At the data cutoff, the median survival times of groups A and B were 8.6 and 11.9 months (P < .05). The adverse reactions in the groups did not show significant differences (P > .05). Among the patients treated with HIFU and chemotherapy, those with small abdominal lymph nodes (diameter <3 cm) had a better prognosis than those with large nodes (diameter ≥3 cm).
  
  
  CONCLUSIONS
  In patients with gastric cancer and abdominal lymph node metastasis, the combination of HIFU and chemotherapy can provide clinical benefits. High-intensity focused ultrasound could effectively facilitate treatment of abdominal lymph node metastasis from gastric cancer.
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Meiling
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Lingxiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Kaihua
authors.initials: K
authors.lastname: Lu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Yongqian
authors.initials: Y
authors.lastname: Shu
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.). liupingdoc@126.com pnigliu@yeah.net.
authors.forename: Rongsheng
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China (M.Z., L.L., J.W., K.L., Y.S., R.W., P.L.); and Cancer Center, Nanjing Medical University, Nanjing, China (Y.S., P.L.).
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use*; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000601:surgery*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil
keywords: gastric cancer; gastrointestinal ultrasound; high-intensity focused ultrasound; lymph node