title: Rotavirus gastroenteritis-associated urinary ammonium acid urate crystals.
abstract: Although ammonium acid urate (AAU) calculi are extremely rare renal stone components, it was recently found that many urinary tract calculi that cause post-renal renal failure in rotavirus (RV) gastroenteritis are AAU calculi. The mechanism of AAU calculi development in RV gastroenteritis has not been fully elucidated. We analyzed data from eight RV gastroenteritis patients who transiently had AAU crystals in their urinary sediment. In these patients, formation of AAU crystals occurred earlier than the formation of AAU calculi. No difference was observed in serum and urine uric acid levels between RV gastroenteritis patients with or without AAU crystals. Interestingly, fractional excretion of sodium was extremely low among patients with AAU crystals. These results suggest that the formation of AAU crystals might not be due to excretion of uric acid, but excretion of sodium.
authors.affiliation: Department of Pediatrics, Fukuiken Saiseikai Hospital, Fukui, Fukui, Japan.
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Naotoshi
authors.initials: N
authors.lastname: Sugimoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kato
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ohta
authors.forename: Sayaka
authors.initials: S
authors.lastname: Ishikawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ueno
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimizu
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D015415:Biomarkers / Q000652:urine; D002675:Child, Preschool; D005759:Gastroenteritis / Q000652:urine / Q000821:virology*; D006801:Humans; D008297:Male; D012401:Rotavirus; D012400:Rotavirus Infections / Q000652:urine / Q000821:virology*; D014527:Uric Acid / Q000652:urine*; D014545:Urinary Calculi / Q000652:urine / Q000821:virology*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: ammonium acid urate crystal; excretion of sodium; rotavirus gastroenteritis; urinary sediment