title: Association of fatty liver with cardiovascular risk factors and subclinical atherosclerosis in a Mexican population.
abstract: BACKGROUND
  Individuals with fatty liver (FL) have an increased risk of coronary artery disease (CAD) probably due to its association with cardiometabolic risk factors (CMRF).
  
  
  OBJECTIVE
  To know the prevalence of FL and analyze its association with CMRF and subclinical atherosclerosis, in a sample of Mexican Mestizo population.
  
  
  METHODS
  This study included 846 subjects from the Genetic of Atherosclerosis Disease (GEA) study (53 ± 9 years, 50.7% women) without diabetes and no personal or family history of premature CAD. Blood samples were taken for measurements of lipids profile, uric acid, and insulin. The presence of FL was identified by computed tomography. Carotid intima media thickness (CIMT) was measured by B mode ultrasound, using the > 75 percentile as cutoff value to define subclinical atherosclerosis.
  
  
  RESULTS
  The general prevalence of FL was 32.4%. In men, FL was associated with hyperuricemia, whereas in women, hyperuricemia, low level of high density lipoprotein cholesterol, and metabolic syndrome were the factors associated with this hepatic alteration. In women, FL was associated with a 66% higher probability of having high CIMT, independently of age, hypertension, dyslipidemia, and waist circumference, but not of HOMA-IR.
  
  
  CONCLUSIONS
  In women, FL was associated with the presence of subclinical atherosclerosis independently of traditional CMRF. Our study suggests that, in women, insulin resistance could be a mediator of metabolic abnormalities and of subclinical atherosclerosis.
authors.forename: María Del Rocío
authors.initials: Mdel R
authors.lastname: Martínez-Alvarado
authors.forename: Juan Gabriel
authors.initials: JG
authors.lastname: Juárez-Rojas
authors.forename: Aída Xóchitl
authors.initials: AX
authors.lastname: Medina-Urrutia
authors.forename: Guillermo Celestino
authors.initials: GC
authors.lastname: Cardoso-Saldaña
authors.forename: María Del Carmen
authors.initials: Mdel C
authors.lastname: González-Salazar
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.forename: Esteban
authors.initials: E
authors.lastname: Jorge-Galarza
authors.forename: Enrique
authors.initials: E
authors.lastname: Mendoza-Pérez
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez.
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D005234:Fatty Liver / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference / Q000502:physiology