title: Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Kanagawa, Japan.
authors.forename: Eijiro
authors.initials: E
authors.lastname: Umemura
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Kanagawa, Japan.
authors.forename: Yukou
authors.initials: Y
authors.lastname: Sakamoto
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Kanagawa, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Kanagawa, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Miyake
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003982:Dibekacin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005839:Gentamicins / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D007612:Kanamycin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; C023804:gentamicin B; D003982:Dibekacin; D007612:Kanamycin