title: Dosing nucleoside reverse transcriptase inhibitors in adults receiving continuous veno-venous hemofiltration.
abstract: OBJECTIVE
  Characteristics of nucleoside reverse transcriptase inhibitors (NRTIs) make the drug class susceptible to elimination via continuous veno-venous hemofiltration (CVVH), potentially leading to suboptimal drug concentrations if given at the recommended anephric doses during CVVH. The objective of this study was to formulate NRTI dosing recommendations for adults receiving CVVH.
  
  
  METHODS
  A mathematical formula that estimates the amount of drug likely to be removed during CVVH at various flow rates was used to calculate the supplemental NRTI dose required during CVVH.
  
  
  RESULTS
  A proposed table of dosing recommendations for NRTIs during CVVH is presented.
  
  
  CONCLUSIONS
  Clinicians should utilize these recommendations in the context of each individual patient, taking into consideration patient-specific factors and severity of illness. Future pharmacokinetic research correlating plasma and intracellular concentrations of NRTIs during CVVH is warranted to elucidate appropriate dosing.
authors.affiliation: Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, 555 31st Street, Downers Grove, IL, 60515, USA, milgriff@nmh.org.
authors.forename: Milena M
authors.initials: MM
authors.lastname: McLaughlin
authors.forename: Abeer T
authors.initials: AT
authors.lastname: Ammar
authors.forename: Lana
authors.initials: L
authors.lastname: Gerzenshtein
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Scarsi
mesh_terms: D000328:Adult; D054796:Drug Dosage Calculations; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*
chemical_list: D018894:Reverse Transcriptase Inhibitors