title: αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice.
abstract: Psychoactive drug-induced cellular activation is a key mechanism to promote neuronal plasticity and addiction. Alpha Ca(2+)/calmodulin-dependent protein kinase II (αCaMKII) and its autophosphorylation play a key role in the development of drug use associated behaviours. It has been suggested that αCaMKII autophosphorylation is necessary for drug-induced neuronal activation in the mesolimbic system. Here, we show an alcohol- and cocaine-induced increase in c-fos expression in the hippocampal dentate gyrus, which is absent in αCaMKII(T286A) autophosphorylation deficient mice. These findings may suggest a role in hippocampal αCaMKII autophosphorylation in the acute neuroplastic effects of alcohol and cocaine.
authors.affiliation: Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
authors.forename: Isabella
authors.initials: I
authors.lastname: Schöpf
authors.affiliation: MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK.
authors.forename: Alanna C
authors.initials: AC
authors.lastname: Easton
authors.affiliation: Department of Child and Adolescent Mental Health, University Clinic Erlangen, Schwabachanlage 6 and 11, 91054 Erlangen, Germany; Department of Biology, Faculty of Science, Karaj branch, Islamic Azad University, Karaj, Iran.
authors.forename: Jalal
authors.initials: J
authors.lastname: Solati
authors.affiliation: Department of Child and Adolescent Mental Health, University Clinic Erlangen, Schwabachanlage 6 and 11, 91054 Erlangen, Germany.
authors.forename: Yulia
authors.initials: Y
authors.lastname: Golub
authors.affiliation: Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.affiliation: Centre for the Cellular Basis of Behavior, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's College London, James Black Centre, 125 Coldharbour Lane, London SE5 8AF, UK.
authors.forename: K Peter
authors.initials: KP
authors.lastname: Giese
authors.affiliation: Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany; MRC Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: Christian.Mueller@uk-erlangen.de.
authors.forename: Christian P
authors.initials: CP
authors.lastname: Müller
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D010766:Phosphorylation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D000431:Ethanol; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D003042:Cocaine
keywords: C-fos; Hippocampus; Immunohistochemistry; αcaMKII(T286A)