title: Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin B1 in broiler chickens.
abstract: Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%.
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Gunther.Antonissen@ugent.be.|Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Gunther.Antonissen@ugent.be.
authors.forename: Gunther
authors.initials: G
authors.lastname: Antonissen
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Mathias.Devreese@ugent.be.
authors.forename: Mathias
authors.initials: M
authors.lastname: Devreese
authors.affiliation: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Filip.VanImmerseel@ugent.be.
authors.forename: Filip
authors.initials: F
authors.lastname: Van Immerseel
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Siegrid.DeBaere@ugent.be.
authors.forename: Siegrid
authors.initials: S
authors.lastname: De Baere
authors.affiliation: Biomin Research Center, Technopark 1, Tulln 3430, Austria. Sabine.Hessenberger@biomin.net.
authors.forename: Sabine
authors.initials: S
authors.lastname: Hessenberger
authors.affiliation: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. An.Martel@ugent.be.
authors.forename: An
authors.initials: A
authors.lastname: Martel
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke 9820, Belgium. Siska.Croubels@ugent.be.
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000032:analysis / Q000633:toxicity; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002645:Chickens / Q000254:growth & development*; D003627:Data Interpretation, Statistical; D005260:Female; D005506:Food Contamination / Q000032:analysis; D037341:Fumonisins / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D014255:Trichothecenes / Q000097:blood / Q000633:toxicity*
chemical_list: D037341:Fumonisins; D014255:Trichothecenes; C056933:fumonisin B1; C007262:deoxynivalenol