title: Effects of acute CDP-choline treatment on resting state brain oscillations in healthy volunteers.
abstract: CDP-choline (cytidine-5'-diphosphocholine) is a phospholipid used to treat cognitive disorders, presumably repairing and maintaining brain cell membranes. Additional mechanisms may include enhanced cholinergic neurotransmission as the α7 nicotinic receptor actions of choline and increased acetylcholine synthesis accompanying CDP-choline administration may modulate brain oscillations underlying cognitive processes. This study utilizes electroencephalographic (EEG) recordings in healthy volunteers to evaluate CDP-choline induction of an oscillatory response profile associated with nicotinic stimulation. Resting state EEG was acquired in 24 male volunteers administered low (500mg) and moderate (1000mg) doses of CDP-choline in a randomized placebo-controlled, crossover trial. Consistent with nicotinic agonist treatment, spectral analysis showed dose-dependent reductions in delta and increases in alpha oscillations, which were also accompanied by decreases in beta and gamma oscillatory activity. These findings support the posit that CDP-choline cognitive enhancement involves multiple mechanisms including facilitated nicotinic cholinergic action.
authors.affiliation: University of Ottawa, Institute of Mental Health Research, Ottawa, ON, Canada; School of Psychology, University of Ottawa, Ottawa, ON, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. Electronic address: Verner.Knott@theroyal.ca.
authors.forename: Verner
authors.initials: V
authors.lastname: Knott
authors.affiliation: School of Psychology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Sara de la
authors.initials: S
authors.lastname: Salle
authors.affiliation: Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Dylan
authors.initials: D
authors.lastname: Smith
authors.affiliation: Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Joelle
authors.initials: J
authors.lastname: Choueiry
authors.affiliation: School of Psychology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Danielle
authors.initials: D
authors.lastname: Impey
authors.affiliation: School of Psychology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Meaghan
authors.initials: M
authors.lastname: Smith
authors.affiliation: School of Psychology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Elise
authors.initials: E
authors.lastname: Beaudry
authors.affiliation: School of Psychology, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Salman
authors.initials: S
authors.lastname: Saghir
authors.affiliation: Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Vadim
authors.initials: V
authors.lastname: Ilivitsky
authors.affiliation: Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Labelle
mesh_terms: D001921:Brain / Q000187:drug effects* / Q000502:physiology; D001931:Brain Mapping; D018592:Cross-Over Studies; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D008297:Male; D018722:Nicotinic Agonists / Q000494:pharmacology*; D012016:Reference Values; D055815:Young Adult
chemical_list: D018722:Nicotinic Agonists; D003566:Cytidine Diphosphate Choline
keywords: Choline; Cognition; Cytidine-5′-diphosphocholine; Nicotinic receptors; Oscillations