title: Association between the RAGE gene -374T/A, -429T/C polymorphisms and diabetic nephropathy: a meta-analysis.
abstract: OBJECTIVE
  The investigations into the association between the receptor for advanced glycation end products (RAGE) gene -374T/A, -429T/C polymorphisms and diabetic nephropathy (DN) in several case-control studies have rendered conflicting results. To shed light on these inconclusive findings, a meta-analysis of all the eligible studies relating these two polymorphisms to the risk of DN was conducted.
  
  
  METHODS
  The databases were searched for relevant articles up to July 2014. A pooled estimate of the genetic association, the heterogeneity between studies, and the publication bias were investigated.
  
  
  RESULTS
  Eight studies with 1725 cases and 1857 controls were enrolled in -374T/A polymorphism analysis. The main analysis indicated no association for the allele contrast, the recessive model and the dominant model. Subgroup analyses in Caucasians and in type 2 diabetes also showed no association between -374T/A polymorphism and DN. Five studies with 1019 cases and 792 controls were enrolled in -429T/C polymorphism analysis. The main analysis revealed heterogeneity and no association for the allele contrast and the dominant model. However, the recessive model for -429C allele diminished the heterogeneity and showed a marginal association overall [fixed-effects OR = 2.83 (1.33-6.00) and random effects OR = 2.50 (1.00-6.24), respectively].
  
  
  CONCLUSIONS
  Our meta-analysis indicated that the RAGE gene -429CC genotype might be a risk factor for DN in patients with type 2 diabetes.
authors.affiliation: a Department of Nephrology , First People's Hospital Affiliated to Huzhou University , Huzhou , Zhejiang , China and.
authors.forename: Zhanqin
authors.initials: Z
authors.lastname: Shi
authors.forename: Weixin
authors.initials: W
authors.lastname: Lu
authors.forename: Guangping
authors.initials: G
authors.lastname: Xie
mesh_terms: D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*; D012307:Risk Factors
chemical_list: C000593871:AGER protein, human; D000067759:Receptor for Advanced Glycation End Products
keywords: Diabetic nephropathy; meta-analysis; polymorphism; receptor for advanced glycation end products