title: Therapeutic effect of continuous exercise training program on serum creatinine concentration in men with hypertension: a randomized controlled trial.
abstract: BACKGROUND
  Creatinine (Cr) has been implicated as an independent predictor of hypertension and exercise has been reported as adjunct therapy for hypertension. The purpose of the present study was to investigate the effect of continuous training programme on blood pressure and serum creatinine concentration in black African subjects with hypertension.
  
  
  METHODS
  Three hundred and fifty seven male patients with mild to moderate (systolic blood pressure [SBP] between 140-180 & diastolic blood pressure [DBP] between 90-109 mmHg) essential hypertension were age matched and randomly grouped into continuous & control groups. The continuous group involved in an 8 weeks continuous training (60-79% HR reserve) of between 45 minutes to 60 minutes, 3 times per week, while the control group remain sedentary. SBP, DBP, VO2max, serum Cr, body mass index (BMI), waist hip ratio (WHR) and percent (%) body fat. Analysis of covariance (ANCOVA) and Pearson correlation tests were used in data analysis.
  
  
  RESULTS
  Findings of the study revealed significant decreased effects of continuous training programme on SBP, DBP, Cr, BMI, WHR, % body fat and significant increase in VO2max at p< 0.05. Serum Cr is significantly and negatively correlated with SBP (-.335), DBP (.194), BMI (.268), WHR (-.258) and % body fat (-.190) at p<0.05.
  
  
  CONCLUSIONS
  The present study demonstrated a rationale bases for the adjunct therapeutic role of moderate intensity continuous exercise training as a multi-therapy in the down regulation of blood pressure, serum Cr, body size and body fat in hypertension.
authors.affiliation: Biomedical Technology Dept., School of Health Technology, Federal University of Technology, Owerri.
authors.forename: L
authors.initials: L
authors.lastname: Sikiru
authors.affiliation: Medical Rehabilitation Dept., Faculty of Health Sciences and Technology, University of Nigeria, Enugu Campus, Enugu, Nigeria.
authors.forename: G C
authors.initials: GC
authors.lastname: Okoye
mesh_terms: D050154:Adiposity; D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005081:Exercise Therapy; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D049629:Waist-Hip Ratio
chemical_list: D003404:Creatinine
keywords: Africa; Blood pressure; Creatinine; Hypertension; body fat; body size