title: Frequency-dependent amplitude alterations of resting-state spontaneous fluctuations in late-onset depression.
abstract: There is limited amplitude of low-frequency fluctuation (ALFF) of resting-state functional magnetic resonance imaging (fMRI) studies in late-onset depression (LOD) but reported different results. This may be due to the impact of different frequency bands. In this study, we examined the ALFF in five different frequency bands (slow-6: 0-0.01 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.167 Hz, and slow-2: 0.167-0.25 Hz) within the whole brain during resting-state fMRI in 16 LOD patients and 16 normal control (NC) subjects. The ALFF of primary effect of disease was widely distributed over left cerebellum anterior lobe, left cerebellum posterior lobe, left middle orbitofrontal gyrus, left superior occipital, and right superior parietal, while the interaction effect of disease and frequency was distributed over right superior frontal gyrus. Further relationship analysis findings suggest these abnormal ALFF may relate to cognitive dysfunction of LOD. Therefore, our data show that LOD patients have widespread abnormalities in intrinsic brain activity, which is dependent on the frequency band, and suggest that future studies should take the frequency bands into account when measuring intrinsic brain activity.
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, No. 87, Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, Zhejiang 310000, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 310000, China.
authors.forename: Xize
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Psychiatry, The 4th People's Hospital of Wuhu City, Wuhu 241000, China.
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, Zhejiang 310000, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, Zhejiang 310000, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zang
authors.affiliation: Department of Psychosomatics and Psychiatry, Affiliated Zhongda Hospital of Southeast University, Medical School of Southeast University, No. 87, Dingjiaqiao Road, Nanjing 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D017668:Age of Onset; D000368:Aged; D001931:Brain Mapping; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003863:Depression / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography