title: Controlled Attenuation Parameter and Liver Stiffness Measurements for Steatosis Assessment in the Liver Transplant of Brain Dead Donors.
abstract: BACKGROUND
  One of the main selection criteria of the quality of a liver graft is the degree of steatosis, which will determine the success of the transplantation. The aim of this study was to evaluate the ability of FibroScan and its related methods Controlled Attenuation Parameter and Liver Stiffness to assess objectively steatosis and fibrosis in livers from brain-dead donors to be potentially used for transplantation.
  
  
  METHODS
  Over a period of 10 months, 23 consecutive brain dead donors screened for liver procurement underwent a FibroScan and a liver biopsy.
  
  
  RESULTS
  The different predictive models of liver retrievability using liver biopsy as the gold standard have led to the following area under receiver operating characteristic curve: 76.6% (95% confidence intervals [95% CIs], 48.2%-100%) when based solely on controlled attenuation parameter, 75.0% (95% CIs, 34.3%-100%) when based solely on liver stiffness, and 96.7% (95% CIs, 88.7%-100%) when based on combined indices.
  
  
  CONCLUSIONS
  Our study suggests that a preoperative selection of brain-dead donors based on a combination of both Controlled Attenuation Parameter and Liver Stiffness obtained with FibroScan could result in a good preoperative prediction of the histological status and degree of steatosis of a potential liver graft.
authors.affiliation: 1 Department of Anesthesiology, Dupuytren Teaching Hospital, Limoges, France. 2 Department of Hepatology, Dupuytren Teaching Hospital, Limoges, France. 3 Medical University of Limoges, Limoges, France. 4 INSERM UMR 1092, Limoges, France. 5 Clinical Investigation Center, INSERM 0203, Pontchaillou Teaching Hospital, Rennes, France. 6 Department of Clinical Pharmacology, Teaching Hospital of Rennes, Rennes, France. 7 Department of Pathology, Dupuytren Teaching Hospital, Limoges, France. 8 Department of Critical Care, Dupuytren Teaching Hospital, Limoges, France. 9 Coordination Hospitalière des Prélèvements d'Organes et de Tissus, Dupuytren Teaching Hospital, Limoges, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Mancia
authors.forename: Véronique
authors.initials: V
authors.lastname: Loustaud-Ratti
authors.forename: Paul
authors.initials: P
authors.lastname: Carrier
authors.forename: Florian
authors.initials: F
authors.lastname: Naudet
authors.forename: Eric
authors.initials: E
authors.lastname: Bellissant
authors.forename: François
authors.initials: F
authors.lastname: Labrousse
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pichon
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001706:Biopsy; D001926:Brain Death; D003661:Decision Support Techniques; D046148:Donor Selection; D054459:Elasticity Imaging Techniques; D005234:Fatty Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D005602:France; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000473:pathology; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012720:Severity of Illness Index; D014019:Tissue Donors; D055815:Young Adult