title: Comparison of the expression of immunomodulatory factors in cultures of mesenchymal stromal cells from human extraembryonic tissues.
abstract: mRNA of genes (tgfβ, il6, il10, il1β, and vegf165) involved in cell proliferation, inflammatory, anti-inflammatory, and angiogenic processes were detected and quantified in cultures of mesenchymal stromal cells of different passages derived from human extraembryonic tissues (amniotic sac, umbilical cord, chorionic villi and trophoblast of the placenta). The concentrations of IL-10, IL-6, IL-1β, and TGFβ were measured.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia, a_savilova@oparina4.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Savilova
authors.forename: A V
authors.initials: AV
authors.lastname: Zakharov
authors.forename: E A
authors.initials: EA
authors.lastname: Metlyuk
authors.forename: Ya V
authors.initials: YV
authors.lastname: Serdyuk
authors.forename: V N
authors.initials: VN
authors.lastname: Veryasov
authors.forename: A M
authors.initials: AM
authors.lastname: Krasnyi
authors.forename: D Yu
authors.initials: DY
authors.lastname: Trofimov
mesh_terms: D002478:Cells, Cultured; D005321:Extraembryonic Membranes / Q000166:cytology*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D016753:Interleukin-10 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014327:Trophoblasts / Q000166:cytology*; D014470:Umbilical Cord / Q000166:cytology*
chemical_list: D007155:Immunologic Factors; D053583:Interleukin-1beta; D015850:Interleukin-6; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D016753:Interleukin-10