title: Hepatitis A outbreak among adults with developmental disabilities in group homes--Michigan, 2013.
abstract: Hepatitis A virus (HAV) infections among persons with developmental disabilities living in institutions were common in the past, but with improvements in care and fewer persons institutionalized, the number of HAV infections has declined in these institutions. However, residents in institutions are still vulnerable if they have not been vaccinated. On April 24, 2013, a resident of a group home (GH) for adults with disabilities in southeast Michigan (GH-A) was diagnosed with hepatitis A and died 2 days later of fulminant liver failure. Four weeks later, a second GH-A resident was diagnosed with hepatitis A. None of the GH-A residents or staff had been vaccinated against hepatitis A. Over the next 3 months, six more cases of hepatitis A were diagnosed in residents in four other Michigan GHs. Three local health departments were involved in case investigation and management, including administration of postexposure prophylaxis (PEP). Serum specimens from seven cases were found to have an identical strain of HAV genotype 1A. This report describes the outbreak investigation, the challenges of timely delivery of PEP for hepatitis A, and the need for preexposure vaccination against hepatitis A for adults living or working in GHs for the disabled.
authors.forename: Susan R
authors.initials: SR
authors.lastname: Bohm
authors.forename: Keira Wickliffe
authors.initials: KW
authors.lastname: Berger
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Hackert
authors.forename: Richard
authors.initials: R
authors.lastname: Renas
authors.forename: Suzanne
authors.initials: S
authors.lastname: Brunette
authors.forename: Nicole
authors.initials: N
authors.lastname: Parker
authors.forename: Carolyn
authors.initials: C
authors.lastname: Padro
authors.forename: Anne
authors.initials: A
authors.lastname: Hocking
authors.forename: Mary
authors.initials: M
authors.lastname: Hedemark
authors.forename: Renai
authors.initials: R
authors.lastname: Edwards
authors.forename: Russell L
authors.initials: RL
authors.lastname: Bush
authors.forename: Yury
authors.initials: Y
authors.lastname: Khudyakov
authors.forename: Noele P
authors.initials: NP
authors.lastname: Nelson
authors.forename: Eyasu H
authors.initials: EH
authors.lastname: Teshale
mesh_terms: D000328:Adult; D015984:Causality; D015897:Comorbidity; D002658:Developmental Disabilities / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000517:prevention & control / Q000706:statistics & numerical data*; D005260:Female; D016352:Group Homes / Q000706:statistics & numerical data*; D006506:Hepatitis A / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D056990:Post-Exposure Prophylaxis / Q000379:methods