title: Anxiogenic- and antidepressant-like behavior in corneally kindled rats.
abstract: BACKGROUND
  Anxiety and depression affect epileptic patients much more often than individuals from the general population. We were interested in whether corneal kindling in rats, which is a model of complex partial seizures with secondary generalization, would influence animal behavior in models of anxiety and depression.
  
  
  METHODS
  Kindling was achieved by transcorneal electric stimulation and fully kindled rats were used in this study. Kindled and sham-stimulated rats were subjected to the elevated plus maze and forced swim test which are believed to be predictive models for anxiety and depression in humans, respectively.
  
  
  RESULTS
  Kindling significantly decreased the percentage of time spent by the rats in open arms relative to time spent in open plus closed arms and it reduced immobility time in the swim test as compared with sham-stimulated rats.
  
  
  CONCLUSIONS
  Our results suggest that corneal kindling produces antidepressant- and anxiety-like effects in rats and it may be a useful model to study epilepsy-associated anxiety.
authors.affiliation: Department of Animal Physiology, Institute of Biology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland. Electronic address: piotr.wlaz@umcs.lublin.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Wlaź
authors.affiliation: Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Poleszak
authors.affiliation: Chair and Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Serefko
authors.affiliation: Department of Pathophysiology, Medical University of Lublin, Lublin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Wlaź
authors.affiliation: Drug-Consult.Net, Magdeburg, Germany.
authors.forename: Chris
authors.initials: C
authors.lastname: Rundfeldt
mesh_terms: D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal; D003863:Depression; D004195:Disease Models, Animal; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats
keywords: Anxiety; Corneal kindling; Depression; Elevated plus maze; Forced swim test