title: Evidence-based decision-making 2: Systematic reviews and meta-analysis.
abstract: The number of studies published in the biomedical literature has dramatically increased over the last few decades. This massive proliferation of literature makes clinical medicine increasingly complex, and information from multiple studies is often needed to inform a particular clinical decision. However, available studies often vary in their design, methodological quality, populations studied and may define the research question of interest quite differently, which can make it challenging to synthesize their conclusions. In addition, since even highly cited trials may be challenged over time, clinical decision-making requires ongoing reconciliation of studies which provide different answers to the same question. Because it is often impractical for readers to track down and review all the primary studies, systematic reviews and meta-analyses are an important source of evidence on the diagnosis, prognosis, and treatment of any given disease. This chapter summarizes methods for conducting and reading systematic reviews and meta-analyses, as well as describing potential advantages and disadvantages of these publications.
authors.affiliation: Division of Nephrology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
authors.forename: Aminu
authors.initials: A
authors.lastname: Bello
authors.forename: Natasha
authors.initials: N
authors.lastname: Wiebe
authors.forename: Amit
authors.initials: A
authors.lastname: Garg
authors.forename: Marcello
authors.initials: M
authors.lastname: Tonelli
mesh_terms: D003657:Decision Making; D019317:Evidence-Based Medicine; D006801:Humans; D015201:Meta-Analysis as Topic; D012196:Review Literature as Topic