title: Epidemiological factors involved in the development of bronchopulmonary dysplasia in very low birth-weight preterm infants.
abstract: BACKGROUND
  In spite of the advances made in perinatal medicine, the incidence of bronchopulmonary dysplasia (BPD) has not decreased and the aetiopathogenesis of the "new" BPD is still a matter for debate. The objectives of the present study were to analyse the epidemiological factors and morbidity associated with the development of BPD in a cohort of very low birth-weight (VLBW) preterm infants.
  
  
  METHODS
  This retrospective observational study included all the preterm infants with birth weight ≤1500 g who were admitted to a tertiary-level hospital NICU from 2008 to 2011. A neurological follow-up was also carried out during the first two years of life.
  
  
  RESULTS
  A total of 140 VLBW infants were analyzed: 28.4% presented oxygen dependence at 28 days, and 17.2% at 36 weeks adjusted gestational age. Predictive factors for the development of BPD were gestational age, birth weight, number of days of parenteral nutrition, number of days to achieve full enteral feeding, number of transfusions, duration of respiratory support and insulin administration, vasoactive drugs, diuretics, sedoanalgesia and postnatal corticosteroids. The neonatal morbidity associated with the development of BPD was late neonatal sepsis, patent ductus arteriosus, retinopathy of prematurity (ROP) and intraventricular hemorrhage. Non-significant associations with neurodevelopmental impairment were observed.
  
  
  CONCLUSIONS
  Predictive factors for the development of BPD were respiratory support, feeding and different types of medication. Moreover, patients with BPD had a higher associated morbidity than those who did not develop BPD.
authors.affiliation: Service of Pediatrics, San Cecilio Clinical Hospital, Granada, Spain.
authors.forename: Marita
authors.initials: M
authors.lastname: Lardón-Fernández
authors.affiliation: Service of Pediatrics, San Cecilio Clinical Hospital, Granada, Spain - juberos@ugr.es.
authors.forename: José
authors.initials: J
authors.lastname: Uberos
authors.affiliation: Service of Pediatrics, San Cecilio Clinical Hospital, Granada, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Molina-Oya
authors.affiliation: Service of Pediatrics, San Cecilio Clinical Hospital, Granada, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Narbona-López
mesh_terms: D001724:Birth Weight; D001997:Bronchopulmonary Dysplasia / Q000453:epidemiology*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D019102:Infant, Very Low Birth Weight; D007363:Intensive Care Units, Neonatal; D010100:Oxygen / Q000008:administration & dosage*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D010100:Oxygen