title: Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer.
abstract: We aimed to analyze the association between the distribution of dendritic cells (DC) with expression of tumor-infiltrating T lymphocytes and clinicopathologic parameters with prognosis in epithelial ovarian cancer (EOC). Thirty-three EOC patient samples were surgically resected, and pathology was examined for clinicopathological variables. Expression of S-100, CD1a, CD45RA and CD45RO was detected using the avidin-biotin complex immunohistochemical technique. The correlation of protein expression with surgical and pathological stage, histological grade, pathological type and prognosis was analyzed. There was significant difference in the CD45RA positive rate in early- and advanced-stage EOC with 50 and 10.5%, respectively (P<0.05). Univariate analysis showed that CD45RO, histological grade and surgical-pathological staging were all factors that influenced the prognosis of patients with EOC. Higher survival rates were found in patients with harboring populations of CD1a(+) DC and CD45RO(+) T lymphocytes or populations of S-100(+) DC and CD45RO(+) T lymphocytes (P<0.05). In addition, histological grade is related to cumulative survival rate. The higher degree of cell differentiation presented better outcome. In conclusion, EOC patients with populations of DC and CD45RO(+) T lymphocytes had a higher survival rate. Histological grade and surgical-pathological stage were independent factors affecting prognosis.
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: 1] Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China [2] Department of Gynecology and Obstetrics, NO.3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201900, China.
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.affiliation: Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: H
authors.initials: H
authors.lastname: Qiu
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: L
authors.initials: L
authors.lastname: Qin
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gynecology and Obstetrics, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: S
authors.initials: S
authors.lastname: Hao
authors.affiliation: Department of General Surgery, Hebei General Hospital, Shijiazhuang, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of pathology, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Research Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: B
authors.initials: B
authors.lastname: Shan
mesh_terms: D000328:Adult; D000368:Aged; D018949:Antigens, CD1 / Q000378:metabolism; D000077216:Carcinoma, Ovarian Epithelial; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology* / Q000401:mortality / Q000601:surgery; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000401:mortality / Q000601:surgery; D016016:Proportional Hazards Models; D009418:S100 Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D009418:S100 Proteins