title: Effects of slow repetitive transcranial magnetic stimulation in patients with corticobasal syndrome.
abstract: Corticobasal syndrome is characterized by asymmetric cortical sensorimotor dysfunction and parkinsonism; an altered cortical excitability has been reported. We explored with transcranial magnetic stimulation the motor cortical excitability in corticobasal syndrome, and the effects of slow repetitive transcranial magnetic stimulation. With transcranial magnetic stimulation, we studied two corticobasal syndrome patients. We determined bilaterally from the first dorsal interosseous muscle: relaxed threshold, and contralateral and ipsilateral silent period. We also evaluated the contralateral silent period after active/sham slow repetitive transcranial magnetic stimulation on the most affected side. At T0 the silent period was bilaterally short. On the most affected side, active slow repetitive transcranial magnetic stimulation induced a short lasting prolongation of the contralateral silent period. In corticobasal syndrome, transcranial magnetic stimulation showed a reduction cortical inhibitory phenomenon potentially reversed transiently by slow repetitive transcranial magnetic stimulation.
authors.affiliation: Clinica Neurologica, Azienda Ospedaliero Universitaria "Maggiore della Carità", C.so Mazzini 18, 28100, Novara, Italy, c_civardi@yahoo.com.
authors.forename: Carlo
authors.initials: C
authors.lastname: Civardi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Pisano
authors.forename: Carmen
authors.initials: C
authors.lastname: Delconte
authors.forename: Alessandra
authors.initials: A
authors.lastname: Collini
authors.forename: Francesco
authors.initials: F
authors.lastname: Monaco
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000503:physiopathology*; D066191:Sensorimotor Cortex / Q000503:physiopathology*; D013577:Syndrome; D050781:Transcranial Magnetic Stimulation / Q000379:methods*