title: [The effects of alkylhydroxybenzenes on homoserine lactone-induced manifestations of quorum sensing in bacteria].
abstract: The effects of four alkylhydroxybenzene (AHB) homologs of different hydrocarbon chain lengths on synthesis of the pigment violacein induced by C6-homoserine lactone (HSL) and biofilm formation by Chromobacterium violaceum NCTC 13274 and on Escherichia coli pAL103 bioluminescence in the presence of C6-oxo-HSL were studied. It was shown that the inhibitory effect of alkylhydroxybenzenes on the growth of C. violaceum increased in the C5-AHB --> C12-AHB series in the absence of this activity in C1-AHB. Sub-inhibitory AHB concentrations reduced violacein production and suppressed biofilm formation. These effects were presented as individual and group regression dependencies between the analyzed parameters. It was shown using the bioluminescent model that the regulatory effects of AHBs are not associated with their direct competition with HSL and that they develop as a result of changes in the sensitivity of bacterial cells to the respective quorum sensing inducer.
authors.forename: D G
authors.initials: DG
authors.lastname: Deriabin
authors.forename: A A
authors.initials: AA
authors.lastname: Kamaeva
authors.forename: A A
authors.initials: AA
authors.lastname: Tolmacheva
authors.forename: G I
authors.initials: GI
authors.lastname: Él'-Registan
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002861:Chromobacterium / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D007211:Indoles / Q000378:metabolism; D008163:Luminescent Measurements; D053038:Quorum Sensing / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D001555:Benzene Derivatives; D003470:Culture Media; D007211:Indoles; C088386:homoserine lactone; D015107:4-Butyrolactone; C063155:violacein