title: Familial hepatopulmonary syndrome in common variable immunodeficiency.
abstract: Common Variable Immunodeficiency (CVID) comprises a heterogeneous group of primary antibody deficiencies which lead to a range of complications, including infectious, neoplastic and inflammatory disorders. This report describes monozygotic twin brothers with CVID who developed cryptogenic liver disease and subsequently hepatopulmonary syndrome (HPS). This is the second report of the association of HPS and CVID. Its occurrence in two identical twins implicates a genetic basis.
authors.affiliation: Department of Clinical Immunology, Addenbrooke's Hospital, Hills Road, Box 109, Cambridge, CB2 0QQ, UK, sophienholmes@gmail.com.
authors.forename: S N
authors.initials: SN
authors.lastname: Holmes
authors.forename: A
authors.initials: A
authors.lastname: Condliffe
authors.forename: W
authors.initials: W
authors.lastname: Griffiths
authors.forename: H
authors.initials: H
authors.lastname: Baxendale
authors.forename: D S
authors.initials: DS
authors.lastname: Kumararatne
mesh_terms: D000293:Adolescent; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000276:immunology; D020065:Hepatopulmonary Syndrome / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D014430:Twins, Monozygotic