title: Therapeutic hypothermia for neonatal encephalopathy.
abstract: OBJECTIVE
  Hypothermia for neonatal encephalopathy is now the standard of care. The purpose of this review is to evaluate recent publications (during the past 18 months) that impact the practice of hypothermia as neuroprotection for neonatal hypoxic-ischemic encephalopathy.
  
  
  RESULTS
  The review will examine recent publications that influence clinical care, including committee opinion, meta-analysis, and reports of how this practice has evolved in the clinical arena. Biomarkers of acute injury and outcome will be examined. Research involving the future of hypothermia will be noted.
  
  
  CONCLUSIONS
  The rate of death or disability following hypothermia therapy has been reduced substantially; the challenge is to evaluate whether mortality or disability can be reduced further following combination therapy.
authors.affiliation: Wayne State University School of Medicine, Neonatal-Perinatal Medicine, Children's Hospital of Michigan and Hutzel Women's Hospital, Detroit, Michigan, USA.
authors.forename: Seetha
authors.initials: S
authors.lastname: Shankaran
mesh_terms: D003131:Combined Modality Therapy; D002658:Developmental Disabilities / Q000517:prevention & control*; D006233:Persons with Disabilities / Q000706:statistics & numerical data*; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents