title: Biology of renal tumour cancer stem cells applied in medicine.
abstract: The present article highlights the diverse role of stem cells in normal kidney and renal cancer, with special emphasis on surface markers. Proteins such as CD105 and CD133 have been reported as being significant in clear cell renal cell carcinoma (ccRCC) cancer stem cells. The role of normal kidney progenitor cells and their surface markers is compared with the role of those surface markers in ccRCC. Subsequently, we state the current hypothesis about origin of tumour-initiating cells along with their clinical and prognostic potential in RCC. Finally, we present future perspectives with respect to recent studies.
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland ; School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland ; Authors contributed equally to the work.
authors.forename: Damian
authors.initials: D
authors.lastname: Matak
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland ; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Poland ; Authors contributed equally to the work.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Szymanski
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Cezary
authors.initials: C
authors.lastname: Szczylik
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Rafal
authors.initials: R
authors.lastname: Sledziewski
authors.affiliation: Emory School of Medicine Atlanta, GA, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Lian
authors.affiliation: Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Poland ; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Bartnik
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland ; Faculty of Biology, University of Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Sobocinska
authors.affiliation: Department of Oncology with Laboratory of Molecular Oncology, Military Institute of Medicine, Warsaw, Poland.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Czarnecka
keywords: cancer stem cells; renal cancer; tumour-initiating cells