title: Neonates with Bartter syndrome have enormous fluid and sodium requirements.
abstract: OBJECTIVE
  Managing neonatal Bartter syndrome by achieving adequate weight gain is challenging. We assessed the correlation between weight gain in neonatal Bartter syndrome and the introduction of fluid and sodium supplementations and indomethacin during the first 4 weeks of life.
  
  
  METHODS
  Daily fluid and electrolytes requirements were analysed using linear regression and Spearman correlation coefficients. The weight gain coefficient was calculated as daily weight gain after physiological neonatal weight loss.
  
  
  RESULTS
  We studied seven infants. The highest weight gain coefficients occurred between weeks two and four in the five neonates who either received prompt amounts of fluid (maximum 810 mL/kg/day) and sodium (maximum 70 mmol/kg/day) or were treated with indomethacin. For the two patients with the highest weight gain coefficient, water and sodium supplementations were decreased in weeks two to four leading to a significant negative Spearman correlation between weight gain and fluid supplements (r = -0.55 and -0.68) and weight gain and sodium supplementations (r = -0.96 and -0.72). The two patients with the lowest weight gain coefficient had positive Spearman correlation coefficients between weight gain and fluid and sodium supplementations.
  
  
  CONCLUSIONS
  Infants with neonatal Bartter syndrome required rapid and enormous fluid and sodium supplementations or the early introduction of indomethacin treatment to achieve adequate weight gain during the early postnatal period.
authors.affiliation: Department of Pediatrics, Division of Pediatric Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Antonio
authors.initials: A
authors.lastname: Azzi
authors.affiliation: Department of Pediatrics, Division of Pediatric Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Hassib
authors.initials: H
authors.lastname: Chehade
authors.affiliation: Department of Pediatrics, Division of Pediatric Nephrology, Robert Debré University Hospital, Paris, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Deschênes
mesh_terms: D000367:Age Factors; D001477:Bartter Syndrome / Q000628:therapy*; D015331:Cohort Studies; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D019587:Dietary Supplements; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D008297:Male; D012982:Sodium, Dietary / Q000627:therapeutic use*; D015430:Weight Gain
chemical_list: D016861:Cyclooxygenase Inhibitors; D012982:Sodium, Dietary; D007213:Indomethacin
keywords: Fluid supplementation; Indomethacin treatment; Neonatal Bartter syndrome; Sodium supplementation; Weight gain