title: [Mathematical modelling of delayed calcium deregulation in brain neurons caused by hyperstimulation of glutamate receptors].
abstract: Mathematical model presented in this paper is based on the data obtained in experimental studies of the mechanism of glutamate-induced deregulation of Ca2+ homeostasis and mitochondrial depolarization in cultured nerve cells. According to our hypothesis the secondary Ca2+ increase during a prolonged glutamate challenge is mainly due to a profound mitochondrial depolarization which stops mitochondrial Ca2+ uptake in the face of continuous Ca2+ influx into the cell. It is supposed that a progressive decrease in mitochondrial NADH during glutamate exposure greatly enhances sensitivity of mitochondria to intracellular Ca-neurotoxicity. A system of equations developed in this work made it possible to provide a satisfactory simulation of most of experimental events observed in the present study.
authors.forename: D S
authors.initials: DS
authors.lastname: Chastukhin
authors.forename: A V
authors.initials: AV
authors.lastname: Borodin
authors.forename: B I
authors.initials: BI
authors.lastname: Khodorov
mesh_terms: D000200:Action Potentials; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D053078:Membrane Potential, Mitochondrial; D008959:Models, Neurological; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017470:Receptors, Glutamate / Q000378:metabolism*
chemical_list: D017470:Receptors, Glutamate; D002118:Calcium