title: Two new indole derivatives from a marine sponge Ircinia sp. collected at Iriomote Island.
abstract: Two new indole derivatives, 5-hydroxy-1H-indole-3-carboxylic acid ethyl ester (1) and 5-hydroxy-1H-indole-3-glyoxylate ethyl ester (2), and seven known indole alkaloids, dragmacidonamine B (3), gesashidine A (4), hyrtiosulawesine (5), hyrtiomanzamine (6), hyrtimomine D (7), hyrtiosine A (8), and 5-hydroxy-1H-indole-3-carbaldehyde (9), were isolated from a marine sponge Ircinia sp., Irciniidae, collected at Iriomote Island. The structures of 1 and 2 were elucidated on the basis of their spectroscopic data. Compound 1 has previously been reported as a synthetic intermediate and this is the first time that it has been obtained from a natural source.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, Sendai, 981-8558, Japan.
authors.forename: Delfly B
authors.initials: DB
authors.lastname: Abdjul
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ukai
authors.forename: Michio
authors.initials: M
authors.lastname: Namikoshi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D052978:Disk Diffusion Antimicrobial Tests; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D062312:Islands; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*
chemical_list: C000604365:5-hydroxy-1H-indole-3-carboxylic acid ethyl ester; C000604366:5-hydroxy-1H-indole-3-glyoxylate ethyl ester; D000900:Anti-Bacterial Agents; D026121:Indole Alkaloids