title: Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis.
abstract: OBJECTIVE
  Abnormal levels of polyunsaturated fatty acids (PUFAs) have been reported in individuals suffering from schizophrenia. The main aim of the present study was to investigate the relationship between erythrocyte membrane fatty acid levels and resting-state brain activity occurring in individuals at ultra-high risk (UHR) of psychosis.
  
  
  METHODS
  The association between erythrocyte membrane fatty acids levels and resting-state brain activity and its value in predicting psychosis was examined in 72 UHR individuals.
  
  
  RESULTS
  In the frontal area, the activity in the fast frequency band Beta2 was positively associated with docosahexaenoic acid (DHA) levels (R = 0.321, P = 0.017), and in the fronto-central area, Beta2 activity showed a positive correlation with eicosapentaenoic acid (EPA) levels (R = 0.305, P = 0.009), regardless of psychosis transition status. Conversely, the slow frequency band Theta was significantly negatively associated with EPA levels in the parieto-occipital region (R = -0.251, P = 0.033. Results also showed that Alpha power was negatively correlated with DHA levels in UHR individuals who did not transition to psychosis, while this correlation was not present in individuals who later transitioned.
  
  
  CONCLUSIONS
  Our results suggest that individuals at UHR for psychosis who have higher basal omega-3 fatty acids levels present with resting EEG features associated with better states of alertness and vigilance. Furthermore, the improvement in the Alpha synchrony observed along with increased DHA levels in participants who did not transition to psychosis is disturbed in those who did transition. However, these interesting results are limited by the small sample size and low statistical power of the study.
authors.affiliation: Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia suzie.lavoie@orygen.org.au.
authors.forename: Suzie
authors.initials: S
authors.lastname: Lavoie
authors.affiliation: School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Whitford
authors.affiliation: Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Benninger
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Martha
authors.initials: M
authors.lastname: Feucht
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Klier
authors.affiliation: Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
authors.forename: Robert K
authors.initials: RK
authors.lastname: McNamara
authors.affiliation: Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Rice
authors.affiliation: Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Miriam R
authors.initials: MR
authors.lastname: Schäfer
authors.affiliation: Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: G Paul
authors.initials: GP
authors.lastname: Amminger
mesh_terms: D000293:Adolescent; D001921:Brain / Q000503:physiopathology*; D004281:Docosahexaenoic Acids / Q000378:metabolism*; D015118:Eicosapentaenoic Acid / Q000378:metabolism*; D004569:Electroencephalography; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D062706:Prodromal Symptoms; D011618:Psychotic Disorders / Q000378:metabolism / Q000503:physiopathology*; D012306:Risk; D012559:Schizophrenia / Q000378:metabolism / Q000503:physiopathology
chemical_list: D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid
keywords: Docosahexaenoic acid; eicosapentaenoic acid; omega-3 polyunsaturated fatty acids; resting EEG; ultra-high risk of psychosis; vigilance