title: Preparation and characterization of quercetin-loaded lipid liquid crystalline systems.
abstract: The aim of the present study was to investigate mixtures of soy phosphatidylcholine (SPC) and glycerol dioleate (GDO) as encapsulation matrices for antioxidant quercetin. The effects of quercetin loading into non-aqueous formulations, non-lamellar liquid crystalline phases and their colloidal dispersions were studied by using synchrotron small angle X-ray diffraction, dynamic light scattering, cryogenic electron microscopy and high performance liquid chromatography. Quercetin incorporation is discussed in the context of lipid aggregation behavior, self-assembled nanostructure and chemical stability. The obtained results show that SPC/GDO-based formulations can incorporate relatively high amounts of quercetin and serve as liquid crystalline delivery vehicles in the form of bulk phases or colloidal dispersions.
authors.affiliation: Department of Analytical and Environmental Chemistry, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: ausra.linkeviciute@ftmc.lt.
authors.forename: A
authors.initials: A
authors.lastname: Linkevičiūtė
authors.affiliation: State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: audrius_misiunas@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Misiūnas
authors.affiliation: Department of Analytical and Environmental Chemistry, Vilnius University, Naugarduko 24, LT-03225 Vilnius, Lithuania; State Research Institute, Center for Physical Sciences and Technology, A. Goštauto 11, LT-01108 Vilnius, Lithuania. Electronic address: naujalis@pfi.lt.
authors.forename: E
authors.initials: E
authors.lastname: Naujalis
authors.affiliation: Biomedical Science, Faculty of Health and Society, Malmö University, SE-20506 Malmö, Sweden. Electronic address: justas.barauskas@mah.se.
authors.forename: J
authors.initials: J
authors.lastname: Barauskas
mesh_terms: D020285:Cryoelectron Microscopy; D004075:Diglycerides / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D050866:Liquid Crystals / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry*
chemical_list: D004075:Diglycerides; D004337:Drug Carriers; D010713:Phosphatidylcholines; D011794:Quercetin; C013965:diolein
keywords: Lipid liquid crystalline nanoparticles; Lipid liquid crystals; Non-lamellar phases; Quercetin; Small angle X-ray diffraction; cryo-TEM