title: Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus.
abstract: The present study compares the efficacy of two recent oral ectoparasiticides containing isoxazolines (NexGard(®), containing afoxolaner and administered at a monthly regimen, and Bravecto™ containing fluralaner and administered at a tri-monthly regimen) against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus ticks on dogs. 24 dogs were randomly allocated to untreated control, NexGard(®) treated, and Bravecto™ treated groups. The treatments were administered on Days 0, 28 and 56 for afoxolaner and on Day 0 for fluralaner. Tick infestations were performed weekly with 50 unfed adult ticks per each species on each dog from Days 30 to 84 (with the exception of R. sanguineus on Day 63). Ticks were counted at 24h post-infestation. The dogs from both treated groups had statistically significantly (p<0.05) less R. sanguineus and D. reticulatus ticks compared to the untreated dogs on all assessment days. Percent efficacy against R. sanguineus ranged from 86.4% to 99.5% at 24h post-infestation for NexGard(®) and from 65.7% to 100% for Bravecto™. Statistically significantly (p<0.05) less R. sanguineus ticks were recorded for NexGard(®) treated dogs compared to Bravecto™ treated dogs on Day 78. Percent efficacy against D. reticulatus ranged from 85.2% to 99.6% at 24h post-infestation for NexGard(®) and from 63.4% to 99.1% for Bravecto™. Statistically significantly (p<0.05) less D. reticulatus ticks were recorded for NexGard(®) treated dogs compared to Bravecto™ treated dogs on Days 71, 78 and 85.
authors.affiliation: Merial S.A.S., 29 Av Tony Garnier, 69007 Lyon, France. Electronic address: Frederic.beugnet@merial.com.
authors.forename: Frederic
authors.initials: F
authors.lastname: Beugnet
authors.affiliation: ClinVet, Bloemfontein, South Africa.
authors.forename: Julian
authors.initials: J
authors.lastname: Liebenberg
authors.affiliation: Merial S.A.S., 29 Av Tony Garnier, 69007 Lyon, France.
authors.forename: Lenaïg
authors.initials: L
authors.lastname: Halos
mesh_terms: D000818:Animals; D003870:Dermacentor / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use; D007555:Isoxazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D048508:Rhipicephalus sanguineus / Q000187:drug effects*; D013984:Tick Infestations / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: C000591860:A1443 compound; D007306:Insecticides; D007555:Isoxazoles; D009281:Naphthalenes; C000589002:afoxolaner
keywords: Afoxolaner; Dermacentor reticulatus; Dogs; Fluralaner; Rhipicephalus sanguineus