title: Serum Uric Acid and Impaired Glucose Tolerance: The Cardiometabolic Risk in Chinese (CRC) Study.
abstract: Serum uric acid (SUA) elevation has been previously related to impaired fasting glucose and type 2 diabetes. The present study was comprehensive to examine the associations between SUA and impaired glucose tolerance (IGT) in Chinese adults. For this purpose, data were collected from a community-based health examination survey conducted in Central China; 2-h glucose (OGTT) and SUA were measured in 1956 men and women. In multivariate models, SUA levels were significantly associated with an increasing trend of 2-h glucose (OGTT) (P for trend < 0.0001). The odds ratios (OR; 95 % CI) of IGT across increasing quartiles of SUA were 1.0, 1.354 (0.948-2.087), 1.337 (0.959-2.251), and 2.192 (1.407-3.416), after adjusting for age, sex, body mass index, waist circumference, fasting insulin, blood pressure, serum lipids, serum creatinine, and estimated glomerular filtration rate. (P for trend = 0.001). In addition, we found an additive pattern between SUA and triglyceride (TG; P = 0.038) or between SUA and low-density lipoprotein cholesterol (LDL-C; P = 0.041) in relation to IGT. SUA was related to IGT in the Chinese adults, independent of other conventional metabolic risk factors. TG and LDL-C might modify the associations.
authors.affiliation: Xuzhou Medical College, Xuzhou, 221009, Jiangsu, China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Qiu
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China.
authors.forename: Xuekui
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Dou
authors.affiliation: Xuzhou Medical College, Xuzhou, 221009, Jiangsu, China.|Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009, Jiangsu, China. mwlj521@163.com.|Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Xuzhou, 221009, Jiangsu, China. mwlj521@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology; D002681:China; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012306:Risk; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D014527:Uric Acid
keywords: Impaired glucose tolerance; Low-density lipoprotein cholesterol; Serum uric acid; Triglyceride