title: Possible role and application of fMRI in the screening of release-active drugs.
abstract: Functional magnetic resonance imaging (fMRI) of the brain was applied for preclinical evaluation of the efficiency of Divaza preparation intended for the treatment of cerebrovascular disorders. Psychological testing (Stroop task) in the magnetic field of fMRI was performed before and after 12-week treatment course using a double blind placebo-controlled protocol. It was shown that standard psychological and neuropsychological protocols do not allow fully estimate the results of treatment, whereas fMRI targeted the pool of cerebral structures activated during task solution. In the treatment group (in contrast to placebo), active zones in these structures were found only during task solution. Thus, resolution capability of fMRI significantly extends the range of rational screening by identifying active zones and can radically change the procedure of selection and clinical trials.
authors.affiliation: Research Institute of Therapy and Preventative Medicine, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: S N
authors.initials: SN
authors.lastname: Duma
authors.forename: M V
authors.initials: MV
authors.lastname: Rezakova
authors.forename: K G
authors.initials: KG
authors.lastname: Mazhirina
authors.forename: E D
authors.initials: ED
authors.lastname: Petrovskii
authors.forename: M A
authors.initials: MA
authors.lastname: Pokrovskii
authors.forename: O A
authors.initials: OA
authors.lastname: Dzhafarova
authors.forename: A A
authors.initials: AA
authors.lastname: Savelov
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000368:Aged; D000906:Antibodies / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000494:pharmacology*; D052250:Nitric Oxide Synthase Type III / Q000276:immunology; D064568:S100 Calcium Binding Protein beta Subunit / Q000494:pharmacology; D057190:Stroop Test; D013647:Task Performance and Analysis
chemical_list: D000906:Antibodies; D004338:Drug Combinations; D018696:Neuroprotective Agents; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D052250:Nitric Oxide Synthase Type III