title: [On possibility of partial restore integrative brain activity in patients with vegetative state].
abstract: A combined approach to neuroreconstructive effects on pathogenesis mechanisms of vegetative state that develops as a result of severe traumatic brain injury (TBI). It is shown that under the influence of chemical transtimpanal vestibular dereception and transcranial micropolarization (TDCS) accelerated and more pronounced therapeutic effect than conventional therapy. Neurophysiological in-depth examination of the dynamics shows that over time in patients in a vegetative state, picking up the intensity, "tension" and "rigidity" of inter-regional cortical interactions in the organization that are beginning to dominate the area TPO cortex of both hemispheres. It is suggested that in the dislocation of the brain stem in severe TBI is vestibulotalamic tract, thanks to its anatomical location, is the least vulnerable. As a result, the prevailing afferentation forming inter-regional cortical interactions is vestibular afferent impulses. On its basis the pathological functional system, blocking the work of other functional systems of the damaged brain. Suggested treatments significantly reduce the amount of vestibular afferent flow and open up the possibility of recovery of more effective interafferential interactions. This greatly facilitates the work of the brain as a multimodal analyzer.
authors.forename: A G
authors.initials: AG
authors.lastname: Naryshkin
authors.forename: A L
authors.initials: AL
authors.lastname: Gorelik
authors.forename: T A
authors.initials: TA
authors.lastname: Skoromets
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Egorov
authors.forename: A V
authors.initials: AV
authors.lastname: Vtorov
authors.forename: I V
authors.initials: IV
authors.lastname: Martynov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009424:Nervous System Physiological Phenomena; D018458:Persistent Vegetative State / Q000503:physiopathology*