title: The 20th anniversary of proteomics and some of its origins.
abstract: The term "proteome" was first introduced into the scientific literature in July 1995. Almost 20 years ago attempts to characterize the "total protein complement able to be encoded by a given genome" only became possible due to privileged access to what were then the world's most complete sets of genomic data. Today, proteomics has become an important pillar in the fields of disease diagnosis and drug research and development, while also playing a critical role in the much larger field of Healthcare Analytics and Biomarker Discovery and Detection. It is important to note that this industry originated mostly from building blocks in analytical science that predated the term "proteomics" by many decades. However, proteomics, as a discipline, has allowed protein scientists to more favorably compete in the face of highly fashionable Big Science and, more specifically, genomics.
authors.affiliation: Skolkovo RusInnovations, Moscow, Russian Federation.
authors.forename: Ian
authors.initials: I
authors.lastname: Humphery-Smith
mesh_terms: D000846:Anniversaries and Special Events; D001315:Australia; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D016045:Human Genome Project; D009174:Mycoplasma / Q000235:genetics / Q000378:metabolism; D045623:Mycoplasma capricolum / Q000235:genetics; D040901:Proteomics / Q000266:history* / Q000379:methods / Q000639:trends*
chemical_list: D001426:Bacterial Proteins
keywords: Animal proteomics; Historical context; Proteome; Replication-induced protein synthesis; Signature peptides; Whole genome analysis