title: A multimodal mapping study of conduction aphasia with impaired repetition and spared reading aloud.
abstract: The present study explores the functional neuroanatomy of the phonological production system in an Italian aphasic patient (SP) who developed conduction aphasia of the reproduction type following brain surgery. SP presented with two peculiar features: (1) his lesion was localized in the superior temporal gyrus, just posterior to the primary auditory cortex and anterior/inferior to and neighboring the Sylvian parietal temporal (Spt) area, and (2) he presented with severely impaired repetition and spelling from dictation of words and pseudowords but spared reading-aloud of words and pseudowords. Structural, functional, fiber tracking and intraoperative findings were combined to analyze SP's pattern of performance within a widely used sensorimotor control scheme of speech production. We found a dissociation between an interrupted sector of the arcuate fasciculus terminating in STG, known to be involved in phonological processing, and a part of the arcuate fasciculus terminating in MTG, which is held to be involved in lexical-semantic processing. We argue that this phonological deficit should be interpreted as a disorder of the feedback system, in particular of the auditory and somatosensory target maps, which are assumed to be located along the Spt area. In patient SP, the spared part of the left arcuate fasciculus originating in MTG may support an unimpaired reading performance, while the damaged part of the left arcuate fasciculus originating in STG may be responsible for his impaired repetition and spelling from dictation.
authors.affiliation: IRCCS "E. Medea", San Vito al Tagliamento (PN), Italy. Electronic address: btomasino@ud.lnf.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Tomasino
authors.affiliation: IRCCS "E. Medea", San Vito al Tagliamento (PN), Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Marin
authors.affiliation: Fisica Medica, A.O. Santa Maria della Misericordia, Udine, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Maieron
authors.affiliation: Unità Operativa di Neuroradiologia, A.O. Santa Maria della Misericordia, Udine, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: D'Agostini
authors.affiliation: IMFR Gervasutta, Udine, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Medeossi
authors.affiliation: IRCCS "E. Medea", San Vito al Tagliamento (PN), Italy; Dipartimento di Scienze Umane, Università di Udine, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Fabbro
authors.affiliation: Unità Operativa di Neuroradiologia, A.O. Santa Maria della Misericordia, Udine, Italy.
authors.forename: Miran
authors.initials: M
authors.lastname: Skrap
authors.affiliation: Dipartimento di Psicologia, Università di Milano-Bicocca, Milano, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Luzzatti
mesh_terms: D000328:Adult; D001037:Aphasia / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007558:Italy; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures; D010100:Oxygen / Q000097:blood; D011932:Reading; D013702:Temporal Lobe / Q000098:blood supply / Q000473:pathology; D014825:Vocabulary
chemical_list: D010100:Oxygen
keywords: Conduction aphasia; Magnetic resonance imaging (MRI); Phonological processing; Reading and writing; Superior temporal gyrus (STG); Sylvian parietal temporal (Spt) area