title: Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa.
abstract: Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.
authors.affiliation: Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
authors.forename: Kevin T
authors.initials: KT
authors.lastname: O'Brien
authors.affiliation: Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Noto
authors.affiliation: Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
authors.forename: Luke
authors.initials: L
authors.lastname: Nichols-O'Neill
authors.affiliation: Department of Chemistry and Biochemistry, Rowan University , 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
authors.forename: Lark J
authors.initials: LJ
authors.lastname: Perez
keywords: Pseudomonas aeruginosa; antivirulence; biofilm inhibition; quorum sensing; structure−activity relationship