title: Lung ILC2s link innate and adaptive responses in allergic inflammation.
abstract: How allergens trigger the T helper 2 (Th2) response that characterizes allergic lung inflammation is not well understood. Epithelium-derived alarmins released after an allergen encounter activate the innate immune system, including group 2 innate lymphoid cells (ILC2s) which produce the type 2 interleukins IL-5 and IL-13. It has been recently shown that ILC2-derived cytokines are responsible not only for the innate responses underlying allergic inflammation but also for the initiation of the adaptive Th2 response. We review the role of lung ILC2s in the development of allergic inflammation and, in the context of recent findings, propose a common pathway wherein ILC2s, activated by the epithelium-derived cytokine IL-33, link the innate and the adaptive responses after allergen encounter in the lung.
authors.affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Itziar
authors.initials: I
authors.lastname: Martinez-Gonzalez
authors.affiliation: Interdisciplinary Oncology Program, University of British Columbia and Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Steer
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia and Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, BC, V5Z 1L3, Canada. Electronic address: ftakei@bccrc.ca.
authors.forename: Fumio
authors.initials: F
authors.lastname: Takei
mesh_terms: D056704:Adaptive Immunity; D000485:Allergens / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D007113:Immunity, Innate; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018793:Interleukin-13 / Q000235:genetics / Q000276:immunology; D000067596:Interleukin-33; D015848:Interleukin-5 / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D008168:Lung / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D015398:Signal Transduction; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology
chemical_list: D000485:Allergens; C578095:IL13 protein, human; C506536:IL33 protein, human; C508599:IL5 protein, human; D018793:Interleukin-13; D000067596:Interleukin-33; D015848:Interleukin-5; D007378:Interleukins