title: Micro(RNA) managing by mTORC1.
abstract: In this issue of Molecular Cell, Ye et al. (2015) demonstrate that mTORC1 globally regulates miRNA biogenesis under nutrient-rich conditions via the E3 ubiquitin ligase Mdm2, which promotes Drosha degradation.
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla CA 92093, USA.
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Jewell
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla CA 92093, USA.
authors.forename: Fabian
authors.initials: F
authors.lastname: Flores
authors.affiliation: Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla CA 92093, USA. Electronic address: kuguan@ucsd.edu.
authors.forename: Kun-Liang
authors.initials: KL
authors.lastname: Guan
mesh_terms: D000818:Animals; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D035683:MicroRNAs / Q000096:biosynthesis*; D046912:Multiprotein Complexes / Q000502:physiology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000502:physiology*; D043244:Ribonuclease III / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D046912:Multiprotein Complexes; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; C513400:Drosha protein, mouse; D043244:Ribonuclease III