title: Tsukamurella inchonensis infection in a child with Hodgkin's lymphoma.
abstract: Tsukamurella spp. infection is a rare but important cause of bacteremia in immunocompromised patients. The organism is an aerobic, Gram-positive, weakly acid-fast bacillus that is difficult to differentiate from other aerobic Actinomycetales by standard laboratory methods. Here, we report on the case of a 14-year-old patient with Hodgkin's lymphoma who, after intensive chemotherapy, developed Tsukamurella inchonensis bacteremia, which was identified on the peripherally inserted central venous catheter (PICC) using 16S rRNA sequencing analysis. The bacteremia was successfully controlled with antimicrobial therapy and subsequent removal of the PICC. This is the first report of bacteremia by Tsukamurella inchonensis in immunocompromised children. Careful observation and prompt analysis of opportunistic infection, including Tsukamurella spp., is very important in immunocompromised children.
authors.affiliation: Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Ochi
authors.forename: Hisamichi
authors.initials: H
authors.lastname: Tauchi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Moritani
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
mesh_terms: D000293:Adolescent; D016470:Bacteremia / Q000209:etiology / Q000382:microbiology*; D001420:Bacteria, Aerobic / Q000302:isolation & purification*; D055499:Catheter-Related Infections / Q000209:etiology / Q000382:microbiology*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D016908:Gram-Positive Bacterial Infections / Q000209:etiology / Q000382:microbiology*; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male
keywords: Hodgkin's lymphoma; Tsukamurella inchonensis; bacteremia; catheter-related bloodstream infection; central venous catheters