title: Rotavirus-associated hemophagocytic lymphohistiocytosis (HLH) after hematopoietic stem cell transplantation for familial HLH.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder of immune regulation. HLH consists of two forms: familial and acquired, the latter which occurs in association with infection, malignancy, rheumatic disease and acquired immune deficiency. Herein, we report a case of acquired HLH in a child who had received allogeneic hematopoietic stem cell transplantation for familial HLH with UNC13D mutation. Based on microbiology, only rotavirus was identified as a possible organism triggering HLH. The patient's fulminant clinical course included acute respiratory failure, a sepsis-like pattern, disseminated intravascular coagulopathy, and rhabdomyolysis, leading to multiorgan failure and death from septic shock.
authors.affiliation: Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea.
authors.forename: Meerim
authors.initials: M
authors.lastname: Park
authors.forename: Yeong Ju
authors.initials: YJ
authors.lastname: Yun
authors.forename: Sung Il
authors.initials: SI
authors.lastname: Woo
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
authors.forename: Nack-Gyun
authors.initials: NG
authors.lastname: Chung
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
mesh_terms: D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D008565:Membrane Proteins / Q000235:genetics; D009102:Multiple Organ Failure; D009154:Mutation; D012401:Rotavirus / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000175:diagnosis / Q000628:therapy / Q000821:virology*
chemical_list: D008565:Membrane Proteins; C507969:UNC13D protein, human
keywords: acquired; familial; hematopoietic stem cell transplantation; hemophagocytic lymphohistiocytosis; rotavirus