title: Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model.
abstract: OBJECTIVE
  The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats.
  
  
  METHODS
  Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups. The groups were orally treated with the methanol:water (80:20) extracts of aerial parts and roots of A. mollis and A. persica. Buserelin acetate (20 mg) was used as the reference drug. The phytochemical contents of the most active extracts were determined by high performance liquid chromatography.
  
  
  RESULTS
  The cystic formation was determined to be significantly decreased with the aerial part extract of A. mollis. A reduction in the endometrioma was also determined for the aerial part extract of A. persica group. However, significant reduction on the levels of cytokine were recorded for the A. mollis aerial part extract group. Therefore, the phytochemical contents of the aerial part extracts of A. mollis. and A. persica were analyzed.
  
  
  CONCLUSIONS
  The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey, akkolesra@gmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Küpeli Akkol
authors.forename: Murside Ayse
authors.initials: MA
authors.lastname: Demirel
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bahadır Acıkara
authors.forename: Ipek
authors.initials: I
authors.lastname: Süntar
authors.forename: Burcin
authors.initials: B
authors.lastname: Ergene
authors.forename: Mert
authors.initials: M
authors.lastname: Ilhan
authors.forename: Serkan
authors.initials: S
authors.lastname: Ozbilgin
authors.forename: Gulcin
authors.initials: G
authors.lastname: Saltan
authors.forename: Hikmet
authors.initials: H
authors.lastname: Keleş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tekin
mesh_terms: D031982:Alchemilla / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004715:Endometriosis / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010936:Plant Extracts