title: Loading amorphous Asarone in mesoporous silica SBA-15 through supercritical carbon dioxide technology to enhance dissolution and bioavailability.
abstract: The aim of this study was to load amorphous hydrophobic drug into ordered mesoporous silica (SBA-15) by supercritical carbon dioxide technology in order to improve the dissolution and bioavailability of the drug. Asarone was selected as a model drug due to its lipophilic character and poor bioavailability. In vitro dissolution and in vivo bioavailability of the obtained Asarone-SBA-15 were significantly improved as compared to the micronized crystalline drug. This study offers an effective, safe, and environmentally benign means of solving the problems relating to the solubility and bioavailability of hydrophobic molecules.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhengzan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Guilan
authors.initials: G
authors.lastname: Quan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qiaoli
authors.initials: Q
authors.lastname: Wu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Zhou
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xuequn
authors.initials: X
authors.lastname: Bai
authors.affiliation: Guangzhou Neworld Pharmaceutical Ltd. Co., Guangzhou, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Li
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Pan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, China. Electronic address: chuanbin_wu@126.com.
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Wu
mesh_terms: D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002245:Carbon Dioxide / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003460:Crystallization; D057927:Hydrophobic and Hydrophilic Interactions; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; C509969:SBA-15; C012195:asarone; D002245:Carbon Dioxide; D012822:Silicon Dioxide
keywords: Amorphous; Bioavailability; Dissolution; Hydrophobic molecules; Mesoporous silica; Supercritical carbon dioxide