title: In situ evaluation of oxidative stress and immunological parameters as ecotoxicological biomarkers in a novel sentinel species (Mimachlamys varia).
abstract: Although the variegated scallop Mimachlamys varia seems to be a suitable sentinel species for contaminant monitoring, no study has identified biomarkers in this species. In order to fill this gap, this study conducted an in situ biomarker approach. M. varia were collected in contaminated and uncontaminated areas and responsiveness of oxidative stress and immunological biomarkers was evaluated in the digestive gland. In parallel, 14 trace element concentrations were evaluated in the same organ. Superoxide dismutase activity and malondialdehyde content responded efficiently to in situ contamination when a certain degree of contamination was reached. Laccase-type phenoloxidase showed a high sensitivity but saturation of the response was highlighted for the highest contaminations. Additionally, correlations were found between biomarkers and trace element concentrations. Taken together, results showed that biomarker approach conducted in the digestive gland of M. varia represents a sensitive analytical tool to highlight ecotoxicological issues in coastal marine ecosystems.
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: thomas.milinkovitch01@univ-lr.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Milinkovitch
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: paco.bustamante@univ-lr.fr.
authors.forename: Paco
authors.initials: P
authors.lastname: Bustamante
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: valerie.huet@univ-lr.fr.
authors.forename: Valérie
authors.initials: V
authors.lastname: Huet
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: reigner.anais@orange.fr.
authors.forename: Anaïs
authors.initials: A
authors.lastname: Reigner
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: carine.churlaud@univ-lr.fr.
authors.forename: Carine
authors.initials: C
authors.lastname: Churlaud
authors.affiliation: Littoral Environnement et Sociétés (LIENSs), UMR 7266, CNRS-Université de La Rochelle, 2 rue Olympe de Gouges, F-17042 La Rochelle Cedex 01, France. Electronic address: helene.thomas@univ-lr.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Thomas-Guyon
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D004064:Digestive System / Q000737:chemistry / Q000201:enzymology; D004784:Environmental Monitoring; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D049897:Pectinidae / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014131:Trace Elements / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D015415:Biomarkers; D014131:Trace Elements; D014874:Water Pollutants, Chemical; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Biomarkers; Mimachlamys varia; Oxidative stress; Phenoloxidase; Trace elements