title: Current trends in using polymer coated gold nanoparticles for cancer therapy.
abstract: The interest in using the polymer-coated gold nanoparticles (P-AuNPs) for various biomedical applications, including the delivery of chemotherapeutic in cancer has been increased in the recent years. Various biocompatible polymers, including poly(ethylene glycol), heparin, hyaluronic acid, chitosan, polystyrene sulfonate, polyethyleneimine and xanthan gum are being used for the surface decoration of AuNPs for various purposes such as to improve the stability of the NPs and the payloads, impart biocompatibility, promote long systemic circulation followed by cellular uptake to utilize the AuNPs as drug/nucleic acid delivery system for cancer therapy. This review is an attempt to elucidate various synthesis strategies explored so far, including direct synthesis, "grafting in" and "grafting from" for the preparation of the P-AuNPs. Various therapeutic applications of the P-AuNPs for cancer treatment have been illustrated.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India.
authors.forename: Omkara Swami
authors.initials: OS
authors.lastname: Muddineti
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India.
authors.forename: Balaram
authors.initials: B
authors.lastname: Ghosh
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Jawahar Nagar, Shameerpet, Hyderabad 500078, Telangana, India. Electronic address: swati.biswas@hyderabad.bits-pilani.ac.in.
authors.forename: Swati
authors.initials: S
authors.lastname: Biswas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006046:Gold / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D006046:Gold
keywords: Cancer; Gold nanoparticles; Polymer; Synthesis; Therapeutic applications