title: Treatment of diffuse alveolar hemorrhage secondary to lupus erythematosus with recombinant activated factor VII administered with a jet nebulizer.
abstract: Diffuse alveolar hemorrhage (DAH) is a serious pulmonary complication in patients with autoimmune diseases who are undergoing chemotherapy or have had hematopoietic stem cell transplantation. The use of recombinant factor VIIa (rFVIIa) to treat the acute phase of DAH by endobronchial bronchoscopy has been shown to have a significant clinical impact on the survival and evolution of these patients. We report a clinical case of a patient with DAH secondary to systemic lupus erythematosus (SLE) who was treated with rFVIIa administered using a jet nebulizer, obtaining an adequate hemostatic effect with immediate control of DAH and a significant improvement in gas exchange.
authors.affiliation: Unidad de Terapia Intensiva, Fundación Clínica Médica Sur, Puente de Piedra 150, Col. Toriello Guerra. Delegación Tlalpan, Mexico, DF 14050 Mexico.
authors.forename: Raúl Carrillo
authors.initials: RC
authors.lastname: Esper
authors.affiliation: Unidad de Terapia Intensiva, Fundación Clínica Médica Sur, Puente de Piedra 150, Col. Toriello Guerra. Delegación Tlalpan, Mexico, DF 14050 Mexico.
authors.forename: Isis Espinoza de Los Monteros
authors.initials: IE
authors.lastname: Estrada
authors.affiliation: Unidad de Terapia Intensiva, Fundación Clínica Médica Sur, Puente de Piedra 150, Col. Toriello Guerra. Delegación Tlalpan, Mexico, DF 14050 Mexico.
authors.forename: Teresa
authors.initials: T
authors.lastname: de la Torre León
authors.affiliation: Unidad de Terapia Intensiva, Fundación Clínica Médica Sur, Puente de Piedra 150, Col. Toriello Guerra. Delegación Tlalpan, Mexico, DF 14050 Mexico.
authors.forename: Agustín Omar Rosales
authors.initials: AO
authors.lastname: Gutiérrez
authors.affiliation: Unidad de Terapia Intensiva, Fundación Clínica Médica Sur, Puente de Piedra 150, Col. Toriello Guerra. Delegación Tlalpan, Mexico, DF 14050 Mexico.
authors.forename: Jorge Arturo Nava
authors.initials: JA
authors.lastname: López
keywords: DAH (recombinant activated factor VII); Diffuse alveolar hemorrhage; Systemic lupus erythematosus (SLE)