title: Relationship between female hormonal and menstrual factors and pancreatic cancer: a meta-analysis of observational studies.
abstract: The objective of this study was to assess the relationship between female hormone and menstrual factors and pancreatic cancer (PC) through a meta-analysis of observational studies. We undertook a systematic literature search up to July 10, 2014 in PubMed and EMBASE databases. Combined relative risks (RRs) were estimated by random-effects models. Subgroup analysis was performed by study design, source of control, and geographic regions. Sensitivity analyses and publication bias were utilized to evaluate the robustness of our results. A total of 27 case-control and cohort studies were retrieved for this meta-analysis. No significant associations were observed between the risk of PC and age at menarche (RR = 0.94, 95% confidence interval [CI] 0.83-1.07), age at menopause (RR = 0.98, 95% CI 0.85-1.13), hysterectomy (RR = 0.97, 95% CI 0.84-1.11), oophorectomy (RR = 1.02, 95% CI 0.82-1.26), hormone replacement therapy (RR = 0.97, 95% CI 0.87-1.08), and oral contraceptives (RR = 1.09, 95% CI 0.96-1.23). This meta-analysis of observational studies does not support the hypothesis that exogenous hormone use and menstrual factors are associated with PC.
authors.affiliation: From the Department of Hepatobiliary Surgery (BT, SY, ZW, SH), Affiliated Hospital of Guilin Medical University; Laboratory of Liver Injury and Repair Molecular Medicine (BT, SH), Guilin Medical University, Guilin; Department of Infectious Diseases (JL), People's Hospital of Beihai, Beihai; and Department of Medical Oncology (YL), Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.forename: Jiannan
authors.initials: J
authors.lastname: Lv
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Shengguang
authors.initials: S
authors.lastname: Yuan
authors.forename: Zhenran
authors.initials: Z
authors.lastname: Wang
authors.forename: Songqing
authors.initials: S
authors.lastname: He
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000706:statistics & numerical data; D008572:Menarche; D008593:Menopause; D064887:Observational Studies as Topic; D010052:Ovariectomy / Q000706:statistics & numerical data; D010190:Pancreatic Neoplasms / Q000453:epidemiology*
chemical_list: D003276:Contraceptives, Oral