title: Longitudinal associations between asthma control, medication adherence, and quality of life among adolescents: results from a cross-lagged analysis.
abstract: OBJECTIVE
  It is not completely clear whether and how medication adherence, asthma control, and quality of life (QOL) predict each other over time. Therefore, the aim of the present study was to examine the longitudinal associations between asthma control, medication adherence, and quality of life among adolescents.
  
  
  METHODS
  In this 3-wave longitudinal study, adolescents (N = 139, Mean age = 11.8) completed questionnaires about their medication adherence (Medication Adherence Report Scale for Asthma), asthma control (Asthma Control Questionnaire), and QOL (Adolescent Asthma Quality of Life Questionnaire) during home visits in the spring/summer of 2011, 2012, and 2013. Cross-lagged analyses examined temporal interrelations between the three variables over the course of 3 years.
  
  
  RESULTS
  Higher QOL at baseline predicted increased medication adherence at follow-up (T2), but did not predict changes in asthma control over time. Medication adherence and asthma control did not predict changes in QOL over time. There were no associations between asthma control and medication adherence over time.
  
  
  CONCLUSIONS
  Interventions could focus on increasing QOL to increase medication adherence in adolescents with asthma.
authors.affiliation: Behavioural Science Institute (BSI), Faculty of Social Sciences, Radboud University Nijmegen, Montessorilaan 3, 6525 HR, Nijmegen, The Netherlands, d.tiggelman@pwo.ru.nl.
authors.forename: Dana
authors.initials: D
authors.lastname: Tiggelman
authors.forename: Monique O M
authors.initials: MO
authors.lastname: van de Ven
authors.forename: Onno C P
authors.initials: OC
authors.lastname: van Schayck
authors.forename: Rutger C M E
authors.initials: RC
authors.lastname: Engels
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires