title: Esophageal and esophagogastric junction cancers, version 1.2015.
abstract: Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ.
authors.forename: Jaffer A
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authors.lastname: Ajani
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authors.forename: Joseph
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authors.initials: CS
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authors.lastname: Hofstetter
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authors.forename: Kory
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authors.lastname: Jasperson
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authors.initials: RN
authors.lastname: Keswani
authors.forename: Lawrence R
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authors.lastname: Kleinberg
authors.forename: W Michael
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authors.lastname: Korn
authors.forename: Stephen
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authors.forename: Mary F
authors.initials: MF
authors.lastname: Mulcahy
authors.forename: Mark B
authors.initials: MB
authors.lastname: Orringer
authors.forename: James A
authors.initials: JA
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authors.lastname: Sasson
authors.forename: Walter J
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authors.lastname: Scott
authors.forename: Vivian E
authors.initials: VE
authors.lastname: Strong
authors.forename: Thomas K
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authors.lastname: Varghese
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Washington
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Willett
authors.forename: Cameron D
authors.initials: CD
authors.lastname: Wright
authors.forename: Debra
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authors.lastname: Zelman
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authors.lastname: Sundar
mesh_terms: D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D004943:Esophagogastric Junction / Q000473:pathology*; D006801:Humans; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000628:therapy*