title: Chemical inhibition of bacterial ribosome biogenesis shows efficacy in a worm infection model.
abstract: The development of antibacterial compounds that perturb novel processes is an imperative in the challenge presented by widespread antibiotic resistance. While many antibiotics target the ribosome, molecules that inhibit ribosome assembly have yet to be used in this manner. Here we show that a novel inhibitor of ribosome biogenesis, lamotrigine, is capable of rescuing Caenorhabditis elegans from an established Salmonella infection, revealing that ribosome biogenesis is a promising target for the development of new antibiotics.
authors.affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Stokes
authors.affiliation: Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Carrie
authors.initials: C
authors.lastname: Selin
authors.affiliation: Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Department of Medical Microbiology and Infectious Disease, University of Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: Silvia T
authors.initials: ST
authors.lastname: Cardona
authors.affiliation: Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada ebrown@mcmaster.ca.
authors.forename: Eric D
authors.initials: ED
authors.lastname: Brown
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017173:Caenorhabditis elegans / Q000382:microbiology*; D000077213:Lamotrigine; D012270:Ribosomes / Q000187:drug effects* / Q000378:metabolism*; D012480:Salmonella Infections / Q000188:drug therapy; D014227:Triazines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D014227:Triazines; D000077213:Lamotrigine