title: [Study of electrokinetic potential of drug micro-carriers prepared from resorbable polymers bioplastotan].
abstract: The study investigates electrokinetic potential of microparticles prepared from biodegradable poly-3-hydroxybutyrate depending upon the method of preparation employed and taking into account the size of particles maintained in liquid media. The ζ-potential of microparticles. prepared from emulsion by solvent evaporation method was -20 mV; the ζ-potential of microparticles prepared by spray drying was reduced to -95 mV. The value of ζ-potential was influenced by drug loading into microparticles; the drug-loaded microparticles maintained in balanced phosphate buffer for 30 days had higher physical stability than those without drug loading.
authors.forename: A M
authors.initials: AM
authors.lastname: Shershneva
authors.forename: A V
authors.initials: AV
authors.lastname: Murueva
authors.forename: E I
authors.initials: EI
authors.lastname: Shishatskaia
authors.forename: T G
authors.initials: TG
authors.lastname: Volova
mesh_terms: D016503:Drug Delivery Systems; D055664:Electrochemical Techniques; D006885:Hydroxybutyrates / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
chemical_list: D006885:Hydroxybutyrates; D011091:Polyesters; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates