title: Retroperitoneal liposarcoma: current insights in diagnosis and treatment.
abstract: Retroperitoneal liposarcoma (RLS) is a rare, biologically heterogeneous tumor that present considerable challenges due to its size and deep location. As a consequence, the majority of patients with high-grade RLS will develop locally recurrent disease following surgery, and this constitutes the cause of death in most patients. Here, we review current insights and controversies regarding histology, molecular biology, extent of surgery, (neo)adjuvant treatment, and systemic treatment including novel targeted agents in RLS.
authors.affiliation: Department of Surgery, Ghent University Hospital , Ghent , Belgium.
authors.forename: Lucas E
authors.initials: LE
authors.lastname: Matthyssens
authors.affiliation: Department of Pathology, Ghent University Hospital , Ghent , Belgium.
authors.forename: David
authors.initials: D
authors.lastname: Creytens
authors.affiliation: Department of Surgery, Ghent University Hospital , Ghent , Belgium.
authors.forename: Wim P
authors.initials: WP
authors.lastname: Ceelen
keywords: MDM2; liposarcoma; radiotherapy; sarcoma; surgery