title: Cannabinoids suppress acute and anticipatory nausea in preclinical rat models of conditioned gaping.
abstract: The sensation of nausea is one of the most debilitating human experiences. Current antiemetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea. Recent preclinical evidence using a selective rat model of nausea (conditioned gaping reactions) has revealed that cannabinoids have great promise as treatments for nausea and that their antinausea effects may be mediated by the interoceptive insular cortex.
authors.affiliation: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Parker
authors.affiliation: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.
authors.forename: E M
authors.initials: EM
authors.lastname: Rock
authors.affiliation: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Sticht
authors.affiliation: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.
authors.forename: K L
authors.initials: KL
authors.lastname: Wills
authors.affiliation: Department of Psychology and Collaborative Neuroscience Graduate Program, University of Guelph, Guelph, Ontario, Canada.
authors.forename: C L
authors.initials: CL
authors.lastname: Limebeer
mesh_terms: D000208:Acute Disease; D000818:Animals; D002185:Cannabidiol / Q000627:therapeutic use; D002186:Cannabinoids / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000502:physiology; D004195:Disease Models, Animal; D009325:Nausea / Q000517:prevention & control*; D051381:Rats; D043884:Receptor, Cannabinoid, CB1 / Q000502:physiology
chemical_list: D002186:Cannabinoids; D043884:Receptor, Cannabinoid, CB1; D002185:Cannabidiol