title: Left ventricular non-compaction -challenges and controversies.
abstract: Cardiomyopathies classification is based on morphological and functional phenotypes and subcategories of familial/genetic and non-familial/non-genetic disease. The non-compaction cardiomyopathy is a rare disorder which is considered to be an unclassified cardiomyopathy according to the ESC Working Group on Myocardial and Pericardial Diseases and the World Health Organization or a primary genetically-determined cardiomyopathy according to the American Heart Association. The diagnosis of non-compaction is challenging and its nosology is debated since this morphological trait can be shared by different cardiomyopathies and non-cardiomyopathy conditions. Myocardial structure has a spectrum from normal variants to the pathological phenotype of non-compaction cardiomyopathy, which reflects the embryonic structure of the human heart due to an arrest in the compaction process during the first trimester. However, when a definite diagnosis of non-compaction is made, the diagnostic process should orient towards a genetic disease with a relatively high probability of sarcomere mutations. Non-compaction cardiomyopathy is a diagnostically challenging entity. Nowadays there are some controversies associated with this cardiomyopathy, that it worth to be discussed.
authors.affiliation: Cardiovascular Disease Institute, Iasi, Romania ; "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Floria
authors.affiliation: Cardiovascular Disease Institute, Iasi, Romania ; "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Grigore
authors.initials: G
authors.lastname: Tinica
authors.affiliation: Cardiovascular Disease Institute, Iasi, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Grecu
keywords: cardiomyopathy; genetic; non-compaction; phenotype