title: Early childhood measles vaccinations are not associated with paediatric IBD: a population-based analysis.
abstract: BACKGROUND
  Early childhood vaccinations have been hypothesized to contribute to the emergence of paediatric inflammatory bowel disease [IBD] in developed countries. Using linked population-based administrative databases, we aimed to explore the association between vaccination with measles-containing vaccines and the risk for IBD.
  
  
  METHODS
  This was a case-control study using the University of Manitoba IBD Epidemiology Database [UMIBDED]. The UMIBDED was linked to the Manitoba Immunization Monitoring System [MIMS], a population-based database of immunizations administered in Manitoba. All paediatric IBD cases in Manitoba, born after 1989 and diagnosed before March 31, 2008, were included. Controls were matched to cases on the basis of age, sex, and region of residence at time of diagnosis. Measles-containing vaccinations received in the first 2 years of life were documented, with vaccinations categorized as 'None' or 'Complete', with completeness defined according to Manitoba's vaccination schedule. Conditional logistic regression models were fitted to the data, with models adjusted for physician visits in the first 2 years of life and area-level socioeconomic status at case date.
  
  
  RESULTS
  A total of 951 individuals [117 cases and 834 controls] met eligibility criteria, with average age of diagnosis among cases at 11 years. The proportion of IBD cases with completed vaccinations was 97%, compared with 94% of controls. In models adjusted for physician visits and area-level socioeconomic status, no statistically significant association was detected between completed measles vaccinations and the risk of IBD (adjusted odds ratio [AOR]: 1.5; 95% confidence interval [CI]: 0.5-4.4; p = 0.419].
  
  
  CONCLUSIONS
  No significant association between completed measles-containing vaccination in the first 2 years of life and paediatric IBD could be demonstrated in this population-based study.
authors.affiliation: Inflammatory Bowel Disease Clinical and Research Centre, Department of Community Health Sciences, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Souradet Y
authors.initials: SY
authors.lastname: Shaw
authors.affiliation: Inflammatory Bowel Disease Clinical and Research Centre, Department of Community Health Sciences, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: James F
authors.initials: JF
authors.lastname: Blanchard
authors.affiliation: Department of Community Health Sciences, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada Department of Community Health Sciences, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada charles.bernstein@umanitoba.ca.
authors.forename: Charles N
authors.initials: CN
authors.lastname: Bernstein
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology*; D008297:Male; D008350:Manitoba / Q000453:epidemiology; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage*; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014611:Vaccination / Q000379:methods*
chemical_list: D008458:Measles Vaccine
keywords: Crohn’s disease; epidemiology; inflammatory bowel disease; measles vaccine; ulcerative colitis