title: Amphicrine carcinoma of the ampullary region.
abstract: Amphicrine carcinoma is a peculiar tumor in which the cells have both exocrine and neuroendocrine differentiation, with mucus and neuroendocrine granules within the cytoplasm. In the 2010 WHO classification of tumors of the digestive tract, they have been included in the intermediate-grade malignant category of mixed adenoneuroendocrine carcinomas (MANECs). These tumors are extremely rare in the gastrointestinal tract. Four cases have been reported in the stomach, three in the pancreas, and one in the liver. To the best of our knowledge, this report describes the first case of amphicrine carcinoma in the ampullary region.
authors.affiliation: Department of Medical Biotechnologies, Pathology Unit, University of Siena, Siena - Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ginori
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lo Bello
authors.forename: Loretta
authors.initials: L
authors.lastname: Vassallo
authors.forename: Sergio Antonio
authors.initials: SA
authors.lastname: Tripodi
mesh_terms: D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology; D000855:Anorexia / Q000209:etiology; D014408:Biomarkers, Tumor / Q000032:analysis*; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D002864:Chromogranins / Q000032:analysis; D003138:Common Bile Duct Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007565:Jaundice / Q000209:etiology; D053552:Keratin-7 / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D009325:Nausea / Q000209:etiology; D060787:Neoplasm Grading; D011956:Receptors, Cell Surface / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis; D014057:Tomography, X-Ray Computed; D015431:Weight Loss
chemical_list: D014408:Biomarkers, Tumor; D002864:Chromogranins; D053552:Keratin-7; D011956:Receptors, Cell Surface; C569014:SYP protein, human; D016708:Synaptophysin; C065686:carcinoembryonic antigen binding protein, human