title: CRISPR/Cas9 and TALE: beyond cut and paste.
abstract: Nuclease-based genome editing has proven to be a powerful and promising tool for disease modeling and gene therapy. Recent advances in CRISPR/Cas and TALE indicate that they could also be used as a targeted regulator of gene expression, as well as being utilized for illuminating specific chromosomal structures or genomic regions.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
authors.forename: Liping
authors.initials: L
authors.lastname: Deng
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.
authors.forename: Ruotong
authors.initials: R
authors.lastname: Ren
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Suzuki
authors.affiliation: Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 USA.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmote
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101 China.|Beijing Institute for Brain Disorders, Beijing, 100069 China.|Center for Molecular and Translational Medicine, CMTM, Beijing, 100101 China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
mesh_terms: D064113:CRISPR-Cas Systems / Q000235:genetics*; D003851:Deoxyribonucleases / Q000235:genetics*; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D023281:Genomics / Q000379:methods*; D006801:Humans; D017393:RNA Editing / Q000235:genetics*
chemical_list: D003851:Deoxyribonucleases