title: Hrr25: an emerging major player in selective autophagy regulation in Saccharomyces cerevisiae.
abstract: As with the case of the mechanism of autophagosome formation, studies in yeast have taken a leading role in elucidating the molecular basis of target recognition during selective autophagy. Degradation targets are recognized by receptor proteins, which also bind to Atg8 homologs on growing phagophore membranes, leading to the loading of the targets into autophagosomes. However, it remains to be elucidated how these processes are regulated. In yeast, receptors also interact with the scaffold/adaptor protein Atg11, which subsequently recruits core Atg proteins onto receptor-target complexes to initiate autophagosome formation. Recently, we found that Hrr25, a homolog of CSNK1D/casein kinase 1δ, regulates 3 of 4 selective autophagy-related pathways in the budding yeast Saccharomyces cerevisiae by a uniform mechanism: phosphoregulation of the receptor-scaffold interaction.
authors.affiliation: a Graduate School of Bioscience and Biotechnology ; Tokyo Institute of Technology ; Yokohama , Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nakatogawa
mesh_terms: D001343:Autophagy / Q000502:physiology*; D047389:Casein Kinase I / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: D008869:Microtubule-Associated Proteins; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins; D047389:Casein Kinase I; C070775:HRR25 protein, S cerevisiae
keywords: Ams1; Atg19; Atg34; Atg36; Cvt pathway; casein kinase 1; nitrogen starvation; pexophagy; selective autophagy; yeast