title: Design and synthesis of novel isoxazole tethered quinone-amino Acid hybrids.
abstract: A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India ; Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh 500 072, India.
authors.forename: P
authors.initials: P
authors.lastname: Ravi Kumar
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India.
authors.forename: Manoranjan
authors.identifier: 0000-0002-4987-0942
authors.initials: M
authors.lastname: Behera
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India.
authors.forename: M
authors.initials: M
authors.lastname: Sambaiah
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India.
authors.forename: Venu
authors.initials: V
authors.lastname: Kandula
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India.
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Payili
authors.affiliation: Centre for Chemical Sciences & Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Andhra Pradesh 500 072, India.
authors.forename: A
authors.initials: A
authors.lastname: Jaya Shree
authors.affiliation: Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Plot No. 28, IDA, Nacharam, Hyderabad, Andhra Pradesh 500 076, India.
authors.forename: Satyanarayana
authors.initials: S
authors.lastname: Yennam