title: Dedifferentiated Liposarcoma of the Gastroesophageal Junction.
abstract: Liposarcoma is one of the most common sarcomas in adults, but very rarely presents as a primary in the upper gastrointestinal system. Herein, we present a 71-year-old male patient who underwent wedge excision biopsy twice and then fine needle aspiration and total gastrectomy for a recurrent gastroeosophageal junction mass. In microscopic sections, both well-differentiated and dedifferentiated components were seen. Tumor cells were positive for MDM2, CDK4 and negative for CD117, DOG1, CD34, SMA, Desmin, S-100, HMB45, SOX10, AE1/AE3, CAM5.2, CK18. Fluorescence in situ hybridization (FISH) was performed and MDM2 gene (12q15) amplification was detected. According to these findings, a diagnosis of dedifferentiated liposarcoma was supported. We believe this is the first reported case of dedifferentiated liposarcoma of the gastroesophageal junction.
authors.affiliation: Departments of Pathology, Marmara University Faculty of Medicine, İSTANBUL, TURKEY.
authors.forename: Gökçe
authors.initials: G
authors.lastname: Aşkan
authors.forename: Pelin
authors.initials: P
authors.lastname: Bağci
authors.forename: Meera
authors.initials: M
authors.lastname: Hameed
authors.forename: Olca
authors.initials: O
authors.lastname: Baştürk
mesh_terms: D000368:Aged; D004943:Esophagogastric Junction / Q000473:pathology*; D006801:Humans; D008080:Liposarcoma / Q000473:pathology*; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*