title: Sleep Blood Pressure Self-Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J-HOP) Study.
abstract: To study whether sleep blood pressure (BP) self-measured at home is associated with organ damage, the authors analyzed the data of 2562 participants in the J-HOP study who self-measured sleep BP using a home BP monitoring (HBPM) device, three times during sleep (2 am, 3 am, 4 am), as well as the home morning and evening BPs. The mean sleep home systolic BPs (SBPs) were all correlated with urinary albumin/creatinine ratio (UACR), left ventricular mass index (LVMI), brachial-ankle pulse wave velocity (baPWV), maximum carotid intima-media thickness, and plasma N-terminal pro-hormone pro-brain-type natriuretic peptide (NTproBNP) (all P<.001). After controlling for clinic SBP and home morning and evening SBPs, associations of home sleep SBP with UACR, LVMI, and baPWV remained significant (all P<.008). Even in patients with home morning BP <135/85 mm Hg, 27% exhibited masked nocturnal hypertension with home sleep SBP ≥120 mm Hg and had higher UACR and NTproBNP. Masked nocturnal hypertension, which is associated with advanced organ damage, remains unrecognized by conventional HBPM.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Department of Sleep and Circadian Cardiology, Jichi Medical University School of Medicine, Tochigi, Japan.
authors.forename: Kazuomi
authors.initials: K
authors.lastname: Kario
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hoshide
authors.forename: Hajime
authors.initials: H
authors.lastname: Haimoto
authors.forename: Kayo
authors.initials: K
authors.lastname: Yamagiwa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Uchiba
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Nagasaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yano
authors.forename: Kazuo
authors.initials: K
authors.lastname: Eguchi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Matsui
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shimizu
authors.forename: Joji
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Shizukiyo
authors.initials: S
authors.lastname: Ishikawa
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D012890:Sleep / Q000502:physiology*
chemical_list: D015415:Biomarkers