title: A single multifunctional nanoplatform based on upconversion luminescence and gold nanorods.
abstract: Lanthanide-doped upconverting nanoparticles (UCNPs), which convert near-infrared (NIR) light to higher energy light have been intensively studied for theranostic applications. Here, we developed a hybrid core/shell nanocomposite with multifunctional properties using a multistep strategy consisting of a gold nanorod (GNR) core with an upconverting NaYF4:Er3+, Yb3+ shell (GNR@NaYF4:Er3+, Yb3+). To use a single excitation beam, the GNR plasmon was tuned to ∼650 nm, which is resonant with the upconverted red Er3+ emission emanating from the 4F9/2 excited state. Thus, under laser irradiation at 980 nm, the intensity ratio of the upconverted green emission (arising from the 2H11/2 and 4S3/2 excited states of Er3+) showed a remarkable thermal sensitivity, which was used to calculate the temperature change due to rapid heat conversion from the GNR core. The red upconversion emission of the GNR@NaYF4:Er3+, Yb3+ core/shell nanocomposite decreased compared with the NaYF4:Er3+, Yb3+ nanoshell structure (without a GNR core), which indicates that energy transfer from NaYF4:Er3+, Yb3+ to the GNR takes place, subsequently causing a photothermal effect. The anticancer drug, doxorubicin, was loaded into the GNR@NaYF4:Er3+, Yb3+ nanocomposites and the drug release profile was evaluated. In particular, the release of doxorubicin was significantly enhanced at lower pH and higher temperature caused by the photothermal effect. This multifunctional nanocomposite, which is suitable for local heating and controlled drug release, shows strong potential for use in cancer therapy.
authors.affiliation: Institut National de la Recherche Scientifique - Énergie, Matériaux et Télécommunications, Université du Québec, 1650 Boulevard Lionel-Boulet, Varennes, Quebec J3X 1S2, Canada. vetrone@emt.inrs.ca.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Federico
authors.initials: F
authors.lastname: Rosei
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Vetrone
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D049449:Luminescence; D008163:Luminescent Measurements / Q000379:methods; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D006046:Gold; D004317:Doxorubicin