title: Association between height and thyroid cancer risk: a meta-analysis of prospective cohort studies.
abstract: While several epidemiological studies have investigated the relationship between height and risk for thyroid cancer, the results were inconsistent. In the present study, a systematic review and meta-analysis of prospective cohort studies was conducted to assess the impact of height on thyroid cancer risk. Online databases were searched up to December 30, 2014, for prospective cohort studies on the association between height and thyroid cancer risk. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using a random-effects model of meta-analysis. In all, 11 articles were included in this meta-analysis, including 15 prospective cohort studies, containing 6,695,593 participants and 7,062 cases of thyroid cancer. By comparing the highest versus the lowest categories of height, we reported that risk of thyroid cancer was increased with height in both men (summary RR = 1.40, 95%CI 1.09-1.78, p = 0.008) and women (summary RR = 1.54, 95%CI 1.30-1.83, p < 0.001). The summary RR of thyroid cancer per 5-cm increase in height was 1.16 (95%CI 1.09-1.23, p < 0.001). The results were similar among men (per 5-cm increase RR = 1.13, 95%CI 1.03-1.23, p = 0.011) and women (per 5-cm increase RR = 1.18, 95%CI 1.10-1.27, p < 0.001). No obvious risk of publication bias was observed. Our meta-analysis provides strong evidence for a dose-response relationship between height and risk of thyroid cancer in both men and women.
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Zhaohai
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.|Department of Medicine, Second Military Medical University, Shanghai, 200433, China.
authors.forename: Robin
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Shihua
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
authors.forename: Yangang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height / Q000502:physiology*; D002648:Child; D004198:Disease Susceptibility / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000503:physiopathology*; D055815:Young Adult
keywords: height; meta-analysis; thyroid cancer