title: Correlation between serum levels of high mobility group box-1 protein and pancreatitis: a meta-analysis.
abstract: BACKGROUND
  Aberrant expression of high mobility group box-1 protein (HMGB1) contributes to the progression of various inflammatory diseases. This meta-analysis focused on the clinical significance of serum HMGB1 levels in pancreatitis patients, with the goal of building a novel diagnostic score model.
  
  
  METHODS
  We conducted a meta-analysis by searching in the PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases without any language restrictions. Studies were pooled and standard mean difference (SMD) and its corresponding 95% confidence intervals (95% CIs) were calculated. Version 12.0 STATA software was used for statistical analysis.
  
  
  RESULTS
  We performed a final analysis of 841 subjects from 12 clinical case-control studies. The meta-analysis results showed a positive association between serum HMGB1 levels and the progression of pancreatitis. In the subgroup analysis by country, high serum level of HMGB1 may be related to pancreatitis progression in China, Korea, Hungary, and Japan populations (all P < 0.05).
  
  
  CONCLUSIONS
  The present meta-analysis indicated that serum HMGB1 level was statistically elevated in patients with pancreatitis, and thus serum levels of HMGB1 could be determined to be a useful biomarker for pancreatitis patients.
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Lian-Jie
authors.initials: LJ
authors.lastname: Lin
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Shengjing Hospital, China Medical University, Sanhao Street No. 36, Heping District, Shenyang 110001, China.
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Zheng
authors.affiliation: Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200000, China.
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Liu
authors.affiliation: Department of Oncology, Renji Hospital, Shanghai Jiao Tong University, Shanghai 200000, China.
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Yang
mesh_terms: D015415:Biomarkers; D016022:Case-Control Studies; D004198:Disease Susceptibility / Q000097:blood* / Q000209:etiology*; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D010195:Pancreatitis / Q000097:blood* / Q000209:etiology*
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; C585491:HMGB1 protein, human