title: Change in portal vein hemodynamics after chemoembolization for hepatocellular carcinoma: evaluation through multilevel dynamic multidetector computed tomography during arterial portography.
abstract: OBJECTIVE
  This study aimed to clarify the effect of embolization with lipiodol on portal vein hemodynamics.
  
  
  METHODS
  Time-density curves of the main portal vein on multilevel dynamic multidetector computed tomography during arterial portography were used to analyze peak computed tomography value (PV), time to PV (TPV), arrival time of contrast medium at the main portal vein (ATMPV), slope [(PV - 150) / (TPV - ATMPV)], and slope ratio (slope after embolization / slope before embolization).
  
  
  RESULTS
  In 20 patients with hepatoma, ATMPV and TPV were significantly prolonged and the time-density curve slope was significantly less after embolization. The difference in TPV increased (P = 0.02) and the slope ratio decreased with increasing embolized volume rate (P < 0.001). Strong correlation (R = -0.86) was found between the slope ratio and the embolized volume rate.
  
  
  CONCLUSIONS
  Time-density curves revealed significant portal vein flow delay after embolization; the degree of which was correlated with the extent of the embolized volume.
authors.affiliation: From the Department of Radiology, Wakayama Medical University, Wakayama, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Murotani
authors.forename: Motoki
authors.initials: M
authors.lastname: Nakai
authors.forename: Morio
authors.initials: M
authors.lastname: Sato
authors.forename: Hiroki
authors.initials: H
authors.lastname: Minamiguchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sonomura
authors.forename: Seiki
authors.initials: S
authors.lastname: Hosokawa
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Nishioku
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011172:Portography / Q000379:methods*; D016896:Treatment Outcome