title: Applanatumin A, a new dimeric meroterpenoid from Ganoderma applanatum that displays potent antifibrotic activity.
abstract: Applanatumin A (1), a novel meroterpenoid dimer, was isolated from the fungus Ganoderma applanatum. Its structure and absolute configuration were assigned on the basis of spectroscopic and computational data. Notably, 1 possesses a new hexacyclic skeleton containing a spiro[benzofuran-2,1'-cyclopentane] motif. A plausible pathway, involving a key Diels-Alder reaction, is proposed for the biosynthesis of 1. Applanatumin A exhibits potent antifibrotic activity in TGF-β1-induced human renal proximal tubular cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany and ∥Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.forename: Lei
authors.initials: L
authors.lastname: Di
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Dai
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Zhu-Liang
authors.initials: ZL
authors.lastname: Yang
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D061565:Cycloaddition Reaction; D005355:Fibrosis / Q000517:prevention & control; D032902:Ganoderma / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology
chemical_list: D013729:Terpenes; D053773:Transforming Growth Factor beta1; C000600474:applanatumin A