title: Real-time tissue elastography: non-invasive evaluation of liver fibrosis in chronic liver disease due to HCV.
abstract: OBJECTIVE
  We evaluated the diagnostic efficacy for advanced fibrosis of real-time tissue elastography (RTE), is a newly introduced non-invasive method, in hepatitis C virus (HCV) patients.
  
  
  METHODS
  Sixty-six chronic liver diseases with HCV (CLD-HCV) were evaluated by RTE, FIB-4, and APRI, as well as biopsy or hepatectomy findings. Seventeen healthy volunteers, and 1 with elevation of transaminase and 5 with liver tumors within their normal liver were enrolled for normal controls. Severe fibrosis was defined as METAVIR score 3 or 4. The tissue elasticity value was expressed by LF-index created by the program incorporated in the ultrasound device. The percentage of fibrosis area in each specimen (%FA) was determined with a personal computer. A receiver operating characteristic curve (ROC) was calculated for each non-invasive method of estimation of fibrosis.
  
  
  RESULTS
  The values for the area under the ROC for LF-index, APRI, and FIB-4 were 0.88, 0.81, and 0.84, respectively. Accuracy, sensitivity, and specificity for prediction of LF-index (>2.8) for severe fibrosis were 86.5%, 78.6%, and 93.6%, respectively, which were better than those of FIB-4 and APRI. LF-index showed a good relationship to %FA (r=0.276, P=0.020).
  
  
  CONCLUSIONS
  RTE is an effective method for predicting severe fibrosis in CLD-HCV.
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiraishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraoka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Aibiki
authors.forename: Tomonari
authors.initials: T
authors.lastname: Okudaira
authors.forename: Tomoe
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Haruka
authors.initials: H
authors.lastname: Tatsukawa
authors.forename: Hiroka
authors.initials: H
authors.lastname: Yamago
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Nakahara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Yoshihumi
authors.initials: Y
authors.lastname: Suga
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Azemoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tanihira
authors.forename: Hideki
authors.initials: H
authors.lastname: Miyata
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirooka
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Hideki
authors.initials: H
authors.lastname: Kawasaki
authors.forename: Keizo
authors.initials: K
authors.lastname: Furuya
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D003661:Decision Support Techniques; D054459:Elasticity Imaging Techniques; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D008103:Liver Cirrhosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D012372:ROC Curve; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001219:Aspartate Aminotransferases