title: High risk factors of atrial fibrillation in type 2 diabetes: results from the Chinese Kailuan study.
abstract: BACKGROUND
  The pathophysiological mechanisms for atrial fibrillation (AF) vulnerability in diabetic patients are largely unclear.
  
  
  OBJECTIVE
  To investigate the high risk factors of AF in Chinese Kailuan diabetes.
  
  
  METHODS
  A retrospective review of AF in Chinese Kailuan diabetes.
  
  
  METHODS
  Research and statistic analysis on the clinical data of 9050 diabetic patients from Kailuan Coal Mine Group Corporation who participated in a health survey from July 2006 to October 2007.
  
  
  RESULTS
  Sixty diabetic patients (50 males and 10 females) were diagnosed with AF during the health checkup, with a prevalence of 0.66% (0.67% in males and 0.62% in females). Univariate analysis showed that patients with AF were older and had higher levels of serum uric acid (UA), pulse pressure, serum c-reactive protein and anti-hypertensive medication usage, but lower levels of fasting blood glucose and triglycerides (TG). Multivariate analysis indicated that older age (OR = 1.09; 95% CI: 1.06-1.12), increased UA (OR = 1.01; 95% CI: 1.00-1.01) and decreased TG (OR = 0.71; 95% CI: 0.55-0.92) were independent predictive factors of AF after adjusting for other variables. After gender stratification, age and UA remained as independent predictive factors of AF in both male and female patients. However, TG had an independent inverse association with AF in male patients only.
  
  
  CONCLUSIONS
  Age and UA are independent predictive factors of AF in both male and female diabetic patients. TG is inversely correlated with AF in male diabetic patients only.
authors.affiliation: From the Department of Endocrinology and Metabolism, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China, From the Department of Endocrinology and Metabolism, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: X
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China.
authors.forename: A
authors.initials: A
authors.lastname: Xing
authors.affiliation: Department of Cardiology, Bethune International Peace Hospital, Shijiazhuang, China and.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China.
authors.forename: S
authors.initials: S
authors.lastname: Qi
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Kailuan General Hospital, Hebei Union University, Tangshan, China.
authors.forename: S
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Internal Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China jhong.pku@163.com.
authors.forename: J
authors.initials: J
authors.lastname: Hong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000453:epidemiology*; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism; D055815:Young Adult
chemical_list: D014280:Triglycerides; D014527:Uric Acid