title: The regulator of calcineurin (RCAN1) an important factor involved in atherosclerosis and cardiovascular diseases development.
abstract: Atherosclerosis, one of the main causes of cardiovascular diseases, is a complex process that involves manifold factors. Besides the vascular lipids accumulation, inflammatory factors could be considered as a proatherogenic factor - RCAN1. RCAN1 is a regulator of calcineurin, both of them being calcium dependent proteins. Recent studies have shown that RCAN1 has an important role in heart valve development. In the same time researchers found that, the atherosclerotic plaques have an up-regulated RCAN1 gene expression. In the near future, it is desirable to elucidate the RCAN1 function and classify it as a possible biochemical marker to diagnose infancy atherosclerosis.
authors.affiliation: Biochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Torac
authors.affiliation: Biochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: L
authors.initials: L
authors.lastname: Gaman
authors.affiliation: Biochemistry Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: V
authors.initials: V
authors.lastname: Atanasiu
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism*; D019703:Calcineurin; D002319:Cardiovascular System / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008954:Models, Biological; D009124:Muscle Proteins / Q000378:metabolism*
chemical_list: D009124:Muscle Proteins; D019703:Calcineurin
keywords: Down Syndrome; RCAN1; atherosclerosis; calcineurin; cardiovascular disease