title: Viral and cellular mechanisms of the innate immune sensing of HIV.
abstract: HIV-1 replicates in immune cells that normally respond to incoming viruses and induce antiviral immune responses. Under this constant surveillance, how HIV-1 interacts with the host to escape immune control and causes immunopathology is still being untangled. Recently, a series of HIV-1 interactions with innate sensors of viruses expressed by immune target cells have been identified. Here, we review the HIV-1 factors that escape, engage and regulate these innate immune sensors. We discuss the general principles of these interactions as well as the remarkable cell-type specificity of the regulatory mechanisms and their resulting immune responses. Innate sensors directly intersect viral replication with immunity, and understanding their triggering, or lack thereof, improves our ability to design immune interventions.
authors.affiliation: Institut Curie, 12 rue Lhomond, 75005 Paris, France; INSERM U932, 12 rue Lhomond, 75005 Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Lahaye
authors.affiliation: Institut Curie, 12 rue Lhomond, 75005 Paris, France; INSERM U932, 12 rue Lhomond, 75005 Paris, France. Electronic address: nicolas.manel@curie.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Manel
mesh_terms: D003600:Cytosol / Q000276:immunology* / Q000821:virology*; D006678:HIV / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate; D011971:Receptors, Immunologic / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D011971:Receptors, Immunologic; D014764:Viral Proteins