title: [Neurocognitive impairments of HIV infected individuals -- preliminary results of a national prevalence study in Hungary].
abstract: BACKGROUND and
  
  
  OBJECTIVE
  The outcome of HIV infection has dramatically improved due to the widespread use of combined antiretroviral therapy (cART). Opportunistic infections faded and internal and hemato-oncological diseases along with neurological conditions came to the forth. Present study is to evaluate neurocognitive performance of the Hungarian HIV infected individuals, at first in this setting. PATIENTS and
  
  
  METHODS
  We performed this cross-sectional pilot study within the frames of a national, single-center; prospective study on group of HIV infected patients, analyzing medical data and neurocognitive performance. Based on international recommendations visual memory, visuomotor coordination, non-verbal learning ability, executive functions and reaction time were tested by six domains of a computerized neuropsychological test battery (Vienna Test System).
  
  
  RESULTS
  Data of 59 enrolled HIV individuals were analysed; nine of whom were women (15%), median age 42.6 (IQR: 32.4-48.1) years. In 32.2% (n=19) of patients neurocognitive impairment was detected. Duration of infection and cART treatment time tended to be longer in impaired group (not significant). Lower CD4 cell count at the time of examination (p=0.047), psychiatric diseases other than depression (p=0.005) were found significantly associated with impairment; tertiary education qualification were more common (p=0.033) among non-affected patients. By correlation analysis age, infected time and duration of cART were significantly associated with motor deficit.
  
  
  CONCLUSIONS
  HAND was detected in almost one third part of examined patients, which largely corresponds that in developed countries were observed. Duration of infection and of cART therapy associated motor deficit was found to be the most common impairment. This finding might be interpreted by direct effect of HIV, neurotoxicity of antiretro virals and also by accelerated ageing of this population.
authors.forename: Botond
authors.initials: B
authors.lastname: Lakatos
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Szabó
authors.forename: Barbara
authors.initials: B
authors.lastname: Bozzai
authors.forename: Dénes
authors.initials: D
authors.lastname: Bánhegyi
authors.forename: Gábor
authors.initials: G
authors.lastname: Gazdag
mesh_terms: D000328:Adult; D003071:Cognition; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000821:virology; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology; D056344:Executive Function; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007858:Learning; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D015995:Prevalence; D011446:Prospective Studies