title: Role of transplantation in the treatment of benign solid tumors of the liver: a review of the United Network of Organ Sharing data set.
abstract: OBJECTIVE
  The role of orthotopic liver transplantation for the treatment of benign solid liver tumors (BSLT) is not well defined.
  
  
  OBJECTIVE
  To analyze outcomes in the United Network of Organ Sharing data set of patients with a diagnosis of BSLT who underwent transplantation.
  
  
  METHODS
  A retrospective analysis of the United Network of Organ Sharing data set was performed for all (N = 87,280) patients who underwent transplantation for BSLT in the United States from October 1, 1988, through January 31, 2013.
  
  
  METHODS
  Demographics, clinicopathological characteristics, distribution of the procedures by region and state, and overall survival rates.
  
  
  RESULTS
  During the study period, 147 liver transplants (0.17%) were to treat BSLT. Sixty-two patients (42.2%) had adenomas, 29 (19.7%) had focal nodular hyperplasia, 25 (17.0%) had hemangiomas, 11 (7.5%) had hepatic epithelioid hemangioendotheliomas, and 20 (13.6%) were classified as having unknown benign tumors. The overall 1-, 3-, and 5-year survival rates were 90.9%, 85.2%, and 81.8%, respectively. Using multivariable analysis, we found that age was the only independent factor associated with patient survival. The overall 5-year survival rate for patients older than 50 years was 88% compared with 91% in younger individuals (95% CI, 148-384; P = .005). Region 3 (Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, and Puerto Rico) contributed the maximum number (33 [22.4%]) of these transplants.
  
  
  CONCLUSIONS
  Although liver transplantation cannot be considered a first-line treatment, it is a valid therapeutic option in selected patients who are not amenable to resection. Only 0.17% of the transplants in the United States are performed for this indication, with satisfying long-term results. Age was an independent predictor of patient survival. Further studies are needed to better understand the role of liver transplantation in the treatment of BSLT.
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Sayee
authors.initials: S
authors.lastname: Sundar Alagusundaramoorthy
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Valery
authors.initials: V
authors.lastname: Vilchez
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Anthony
authors.initials: A
authors.lastname: Zanni
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Achuthan
authors.initials: A
authors.lastname: Sourianarayanane
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Erin
authors.initials: E
authors.lastname: Maynard
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Malay
authors.initials: M
authors.lastname: Shah
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Michael F
authors.initials: MF
authors.lastname: Daily
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Pena
authors.affiliation: Department of Surgery, College of Medicine, University of Kentucky, Lexington.
authors.forename: Roberto
authors.initials: R
authors.lastname: Gedaly
mesh_terms: D000328:Adult; D016208:Databases, Factual; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D018579:Patient Selection; D015996:Survival Rate; D014481:United States / Q000453:epidemiology