title: Histopathological alterations in the prostates of Mongolian gerbils exposed to a high-fat diet and di-n-butyl phthalate individually or in combination.
abstract: Both high-fat diet and exposure to endocrine-disrupting chemicals have been implicated in susceptibility to pathological prostate lesions, but the consequences of combining the two have not yet been examined. We evaluated the effects of gestational and postnatal exposure to a high-fat diet (20% fat) and low doses of di-n-butyl phthalate (DBP; 5mg/kg/day), individually or in combination, on the tissue response and incidence of pathological lesions in the ventral prostate of adult gerbils. Continuous intake of a high-fat diet caused dyslipidemia, hypertrophy, and promoted the development of inflammatory, premalignant and malignant prostate lesions, even in the absence of obesity. Life-time DBP exposure was obesogenic and dyslipidemic and increased the incidence of premalignant prostate lesions. Combined exposure to DBP and a high-fat diet also caused prostate hypertrophy, but the effects were less severe than those of individual treatments; combined exposure neither induced an inflammatory response nor altered serum lipid content.
authors.affiliation: Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: marimarcielo@hotmail.com.
authors.forename: Mariana Marcielo
authors.initials: MM
authors.lastname: de Jesus
authors.affiliation: Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: acnegrin@gmail.com.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Negrin
authors.affiliation: Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Univ Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil. Electronic address: taboga@ibilce.unesp.br.
authors.forename: Sebastião Roberto
authors.initials: SR
authors.lastname: Taboga
authors.affiliation: Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Univ Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil. Electronic address: mep.fochi@yahoo.com.br.
authors.forename: Maria Etelvina
authors.initials: ME
authors.lastname: Pinto-Fochi
authors.affiliation: Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Univ Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil. Electronic address: remagoes@ibilce.unesp.br.
authors.forename: Rejane Maira
authors.initials: RM
authors.lastname: Góes
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D003993:Dibutyl Phthalate / Q000633:toxicity*; D059305:Diet, High-Fat / Q000009:adverse effects*; D052244:Endocrine Disruptors / Q000633:toxicity; D005849:Gerbillinae; D006728:Hormones / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D011467:Prostate / Q000737:chemistry / Q000473:pathology*; D011469:Prostatic Diseases / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000209:etiology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000473:pathology; D011944:Receptors, Androgen / Q000032:analysis
chemical_list: D016207:Cytokines; D052244:Endocrine Disruptors; D006728:Hormones; D008055:Lipids; D011944:Receptors, Androgen; D003993:Dibutyl Phthalate
keywords: Di-n-butyl phthalate; High-fat diet; Histopathological lesions; Inflammatory disorders; Microinvasive carcinoma; Mongolian gerbil; Prostate; Prostatic intraepithelial neoplasia