title: The role of STAT3 in tumor-mediated immune suppression.
abstract: The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.
authors.affiliation: Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Blvd., Unit 442, Houston, TX, 77030, USA, sdferguson@mdanderson.org.
authors.forename: Sherise D
authors.initials: SD
authors.lastname: Ferguson
authors.forename: Visish M
authors.initials: VM
authors.lastname: Srinivasan
authors.forename: Amy B
authors.initials: AB
authors.lastname: Heimberger
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D005909:Glioblastoma / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism / Q000627:therapeutic use; D050796:STAT3 Transcription Factor / Q000172:deficiency / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*
chemical_list: D007166:Immunosuppressive Agents; D050796:STAT3 Transcription Factor