title: The presence of Helicobacter pylori in laryngeal squamous cell carcinoma.
abstract: A definitive relationship between Helicobacter pylori (HP) and upper respiratory tract disorders has not been established. In this case-control study, we investigated the relationship between HP and laryngeal carcinoma by real-time PCR method in Turkey. 74 subjects were enrolled from patients who were admitted to the Otolaryngology Department. Formalin-fixed-paraffin-embedded tissue samples with laryngeal cancer were used and all samples were evaluated by real-time PCR method. Our study population included 72 males and 2 females with a mean age range of 62.7 years. Helicobacter Pylori was detected in only one case. The positive case was also investigated with histopathologic evaluation and HP immunohistochemistry. However, we could not detect HP in this case with both methods. This study revealed that HP might not contribute to the pathogenesis of laryngeal carcinoma. A definitive relationship between HP and upper respiratory tract disorders has not been established.
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Yilmaz
authors.affiliation: Department of Otorhinolaryngology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey. evrenerkul@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: Erkul
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Berber
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: Z
authors.initials: Z
authors.lastname: Kucukodaci
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Narli
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Haholu
authors.affiliation: Department of Pathology, Gulhane Military Medical Academy, Haydarpasa Training Hospital, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Demirel
mesh_terms: D001706:Biopsy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000382:microbiology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000382:microbiology / Q000473:pathology; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic
keywords: Carcinoma; Helicobacter pylori; Laryngeal; Real-Time PCR; Squamous