title: T-cell/histiocyte-rich large B-cell lymphoma in pediatric patients: an under-recognized entity?
abstract: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) under-recognized in the pediatric population. A meticulous workup is necessary to avoid a misdiagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) or classical Hodgkin lymphoma (HL). A strong degree of suspicion and an emphasis on immunohistochemical staining are required to reach the diagnosis. Few children with advanced stage disease have been described to date. We report two pediatric patients with high stage THRLBCL and highlight their clinical and pathological features.
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI ggheorghe@mcw.edu.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Gheorghe
authors.affiliation: Pediatric Hematology/Oncology/Blood and Marrow Transplant, Nationwide Children's Hospital, Columbus, OH.
authors.forename: Hemalatha G
authors.initials: HG
authors.lastname: Rangarajan
authors.affiliation: Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Bruce
authors.initials: B
authors.lastname: Camitta
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: Annette
authors.initials: A
authors.lastname: Segura
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Kroft
authors.affiliation: Department of Pathology and Laboratory Medicine, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI.
authors.forename: James F
authors.initials: JF
authors.lastname: Southern
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D064170:Paraspinal Muscles / Q000473:pathology; D013131:Spine / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*
keywords: Hodgkin lymphoma; Nodular Lymphocyte Predominant Hodgkin Lymphoma; T-cell/histiocyte-rich Large B-cell lymphoma; bone marrow; pediatric