title: Organoaluminum-mediated direct cross-coupling reactions.
abstract: We present a direct cross-coupling reaction between arylaluminum compounds (ArAlMe2 ⋅LiCl) and organic halides RX (R=aryl, alkenyl, alkynyl; X=I, Br, and Cl) without any external catalyst. The reaction takes place smoothly, simply upon heating, thereby enabling the efficient and chemo-/stereoselective formation of biaryl, alkene, and alkyne coupling products with broad functional group compatibility.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo-to 113-0033 (Japan).
authors.forename: Hiroki
authors.initials: H
authors.lastname: Minami
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Saito
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uchiyama
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis; D000480:Alkynes / Q000138:chemical synthesis; D000535:Aluminum / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006219:Halogens / Q000138:chemical synthesis / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D006219:Halogens; D009942:Organometallic Compounds; D011084:Polycyclic Aromatic Hydrocarbons; D000535:Aluminum
keywords: CC bond formation; cross-coupling; organic halides; organoaluminum; selectivity