title: The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3.
abstract: The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a "first-in-class Golgi oncoprotein" and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumors. Furthermore this protein has been associated with poor prognosis in many cancers. Highly conserved from yeast to humans, GOLPH3 provides an essential function in vesicle trafficking and Golgi structure. Recent data have also implicated this oncoprotein in regulation of cytokinesis, modulation of mitochondrial mass and cellular response to DNA damage. A minute dissection of the molecular pathways that require GOLPH3 protein will be helpful to develop new therapeutic cancer strategies.
authors.affiliation: Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Sechi
authors.affiliation: Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Frappaolo
authors.affiliation: Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Belloni
authors.affiliation: Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Gianni
authors.initials: G
authors.lastname: Colotti
authors.affiliation: Istituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma, 00185 Roma, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Giansanti
mesh_terms: D000818:Animals; D006056:Golgi Apparatus / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C429024:GOLPH3 protein, human; D008565:Membrane Proteins