title: Accurate connection strength estimation based on variational bayes for detecting synaptic plasticity.
abstract: Connection strength estimation is widely used in detecting the topology of neuronal networks and assessing their synaptic plasticity. A recently proposed model-based method using the leaky integrate-and-fire model neuron estimates membrane potential from spike trains by calculating the maximum a posteriori (MAP) path. We further enhance the MAP path method using variational Bayes and dynamic causal modeling. Several simulations demonstrate that the proposed method can accurately estimate connection strengths with an error ratio of less than 20%. The results suggest that the proposed method can be an effective tool for detecting network structure and synaptic plasticity.
authors.affiliation: Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan 113-8656 and Japan Society for the Promotion of Science, Chiyoda, Tokyo, Japan 102-0083 isomura@neuron.t.u-tokyo.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Isomura
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kotani
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Jimbo