title: Risk factors of severe hand, foot and mouth disease complicated with cardiopulmonary collapse.
abstract: BACKGROUND
  The aim of this study was to investigate the risk factors for severe hand, foot and mouth disease (HFMD) complicated with cardiopulmonary collapse in children.
  
  
  METHODS
  In total, 176 children aged 6-45 months with severe HFMD from March 2013 to May 2014 were enrolled in the study and divided into two groups, one with cardiopulmonary collapse and the other without. Univariate analysis and multiple logistic regression analysis were used to analyze the risk factors for severe HFMD complicated with cardiopulmonary collapse.
  
  
  RESULTS
  The univariate analysis showed that there was no significant correlation between age, body temperature, consciousness disorders, blood glucose level and severe HFMD complicated with cardiopulmonary collapse. The multiple logistic regression analysis demonstrated that vomiting, circulatory disturbance, enterovirus 71 infection, dysfunction of respiratory rhythm and high level of brain natriuretic peptide were five independent risk factors for severe HFMD complicated with cardiopulmonary collapse.
  
  
  CONCLUSIONS
  Children with HFMD and the above five risk factors may be at risk for cardiopulmonary collapse and poor prognosis.
authors.affiliation: From the Department of Intensive Care Unit II, Zhengzhou Children's Hospital , Zhengzhou , PR China.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Song
authors.forename: Cheng
authors.initials: C
authors.lastname: Yibing
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Guo
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Jin
authors.forename: Yajie
authors.initials: Y
authors.lastname: Cui
authors.forename: Xue
authors.initials: X
authors.lastname: Gu
mesh_terms: D002675:Child, Preschool; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000150:complications* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D045265:Natriuretic Peptides / Q000378:metabolism; D011379:Prognosis; D011660:Pulmonary Heart Disease / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D045265:Natriuretic Peptides
keywords: Cardiopulmonary collapse; foot and mouth disease; hand; risk factors