title: Can topiramate induce pruritus? A case report and review of literature.
abstract: A 41-year-old woman with Major Depressive Disorder-Recurrent was treated with topiramate at 150 mg/day. After this administration, she developed intense pruritus and skin lesions due to scratching. Consequently, she was weaned off topiramate and the lesions regressed. Pruritus and cutaneous lesions are extremely rare side effects of topiramate, so we report an interesting case of skin reaction to this drug.
authors.affiliation: Department of Clinical and Molecular Biomedicine, University of Catania, via S. Sofia, 78 Catania, Italy. signorellims@hotmail.com.
authors.forename: Maria S
authors.initials: MS
authors.lastname: Signorelli
authors.forename: Maria
authors.initials: M
authors.lastname: Cinconze
authors.forename: Maria R
authors.initials: MR
authors.lastname: Nasca
authors.forename: Monica
authors.initials: M
authors.lastname: Marino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Giannantonio
authors.forename: Eugenio
authors.initials: E
authors.lastname: Aguglia
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D011537:Pruritus / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology; D000077236:Topiramate
chemical_list: D000928:Antidepressive Agents; D000077236:Topiramate; D005632:Fructose