title: The pivotal role of PDGF and its receptor isoforms in adipose-derived stem cells.
abstract: Platelet-derived growth factor (PDGF) is one of the growth factors that reportedly regulates cell growth and division of mesenchymal cells. Although PDGF isoforms and their receptors reportedly play a pivotal role in mesenchymal stem cell regulation, there is a paucity of literature reviewing the role of PDGF in adipose-derived stem cells (ASCs). Therefore, we summarized previous reports on the expression and functional roles of PDGF and its receptor isoforms in this review. In addition, we examined findings pertaining to underlying molecular mechanisms and signaling pathways with special focus on PDGF-D/PDGFRβ. ASCs only express PDGF-A, -C, -D, PDGFRα, and PDGFRβ. PDGFRα expression decreases with adipocyte lineage, while PDGFRβ inhibits white adipocyte differentiation. In addition, PDGFRβ induces proliferation, migration, and angiogenesis and up-regulates the expression of paracrine factors in ASCs. Although PDGF-B and -D mediate their functions mainly by PDGFRβ and ROS generation, there are many differences between them in terms of regulating ASCs. PDGF-D is endogenous, generates ROS via the mitochondrial electron transport system, and regulates the autocrine loop of ASCs in vivo. Furthermore, PDGF-D has stronger mitogenic effects than PDGF-B.
authors.affiliation: Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Won-Serk
authors.initials: WS
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yonsei University, Incheon, Korea.
authors.forename: Hyung-Sook
authors.initials: HS
authors.lastname: Park
authors.affiliation: College of Pharmacy, Yonsei University, Incheon, Korea. brian99@empal.com.
authors.forename: Jong-Hyuk
authors.initials: JH
authors.lastname: Sung
mesh_terms: D000273:Adipose Tissue / Q000166:cytology* / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D008954:Models, Biological; D019899:Paracrine Communication; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
chemical_list: D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D017479:Receptors, Platelet-Derived Growth Factor