title: Silver-catalyzed double-decarboxylative cross-coupling of α-keto acids with cinnamic acids in water: a strategy for the preparation of chalcones.
abstract: A silver-catalyzed double-decarboxylative protocol has been proposed for the construction of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids under the mild aqueous conditions. The developed method for constructing C-C bonds via double-decarboxylative reactions is efficient, practical, and environmentally benign by using the readily available starting materials. It should provide a promising synthesis candidate for the formation of diverse and useful chalcone derivatives in the fields of synthetic and pharmaceutical chemistry.
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Daoshan
authors.initials: D
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Yuan
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Fafa
authors.initials: F
authors.lastname: Nie
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Laijin
authors.initials: L
authors.lastname: Tian
authors.affiliation: The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry; D002934:Cinnamates / Q000737:chemistry*; D003653:Decarboxylation; D007651:Keto Acids / Q000737:chemistry*; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D047188:Chalcones; D002934:Cinnamates; D007651:Keto Acids; D014867:Water; C029010:cinnamic acid; D012834:Silver