title: Serum apolipoprotein A-I and large high-density lipoprotein particles are positively correlated with FEV1 in atopic asthma.
abstract: BACKGROUND
  Although lipids, apolipoproteins, and lipoprotein particles are important modulators of inflammation, varying relationships exist between these parameters and asthma.
  
  
  OBJECTIVE
  To determine whether serum lipids and apolipoproteins correlate with the severity of airflow obstruction in subjects with atopy and asthma.
  
  
  METHODS
  Serum samples were obtained from 154 atopic and nonatopic subjects without asthma, and 159 subjects with atopy and asthma. Serum lipid and lipoprotein levels were quantified using standard diagnostic assays and nuclear magnetic resonance (NMR) spectroscopy. Airflow obstruction was assessed by FEV1% predicted.
  
  
  RESULTS
  Serum lipid levels correlated with FEV1 only in the subjects with atopy and asthma. Serum levels of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) were positively correlated with FEV1 in subjects with atopy and asthma, whereas a negative correlation existed between FEV1 and serum levels of triglycerides, low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB), and the apoB/apoA-I ratio. NMR spectroscopy identified a positive correlation between FEV1 and HDLNMR particle size, as well as the concentrations of large HDLNMR particles and total IDLNMR (intermediate-density lipoprotein) particles in subjects with atopy and asthma. In contrast, LDLNMR particle size and concentrations of LDLNMR and VLDLNMR (very-low-density lipoprotein) particles were negatively correlated with FEV1 in subjects with atopy and asthma.
  
  
  CONCLUSIONS
  In subjects with atopy and asthma, serum levels of apoA-I and large HDLNMR particles are positively correlated with FEV1, whereas serum triglycerides, LDL cholesterol, and apoB are associated with more severe airflow obstruction. These results may facilitate future studies to assess whether apoA-I and large HDLNMR particles can reduce airflow obstruction and disease severity in asthma.
authors.affiliation: 1 Laboratory of Asthma and Lung Inflammation, NHLBI.
authors.forename: Amisha V
authors.initials: AV
authors.lastname: Barochia
authors.forename: Maryann
authors.initials: M
authors.lastname: Kaler
authors.forename: Rosemarie A
authors.initials: RA
authors.lastname: Cuento
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gordon
authors.forename: Nargues A
authors.initials: NA
authors.lastname: Weir
authors.forename: Maureen
authors.initials: M
authors.lastname: Sampson
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Fontana
authors.forename: Sandra
authors.initials: S
authors.lastname: MacDonald
authors.forename: Joel
authors.initials: J
authors.lastname: Moss
authors.forename: Vincent
authors.initials: V
authors.lastname: Manganiello
authors.forename: Alan T
authors.initials: AT
authors.lastname: Remaley
authors.forename: Stewart J
authors.initials: SJ
authors.lastname: Levine
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000097:blood / Q000503:physiopathology; D016632:Apolipoprotein A-I / Q000097:blood*; D001249:Asthma / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
chemical_list: D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL
keywords: airflow obstruction; apolipoproteins; asthma; lipids; lipoprotein particles