title: Repair of Bone Defects Filled with New Calcium Aluminate Cement (EndoBinder).
abstract: BACKGROUND
  The aim of this study was to evaluate and compare the repair of bone defects filled with calcium aluminate cement (EndoBinder), mineral trioxide aggregate (MTA), and calcium hydroxide.
  
  
  METHODS
  After mixing, the cements were inserted into bone defects (3.3 mm) mechanically created in the right and left tibias of 30 rats (Rattus norvegicus, Wistar). In the control group, the bone defects were filled with blood clot of the animal itself. After time intervals of 7, 30, and 90 days had elapsed, bone tissue biopsies (n = 5) were surgically obtained and submitted to laboratory processing. The response of bone tissue in contact with the materials was microscopically analyzed. The percentage of neoformed bone tissue in the defect was determined by means of planimetry counting points superimposed on the histologic image.
  
  
  RESULTS
  Significant increase in the percentage of neoformed bone tissue was observed throughout the experimental periods in all groups (P < .05). For the cements EndoBinder and MTA (30 and 90 days), these percentage values were statistically higher than those of the control group (P < .05); however, they were similar to those of calcium hydroxide (P > .05).
  
  
  CONCLUSIONS
  EndoBinder and MTA allowed complete repair of bone defects created in rat tibias.
authors.affiliation: Department of Physiology and Pathology, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
authors.forename: Lucas da Fonseca Roberti
authors.initials: Lda F
authors.lastname: Garcia
authors.affiliation: Department of Physiology and Pathology, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Huck
authors.affiliation: Department of Diagnosis and Surgery, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil.
authors.forename: Cassio Rocha
authors.initials: CR
authors.lastname: Scardueli
authors.affiliation: Department of Physiology and Pathology, Araraquara School of Dentistry, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil. Electronic address: casouzac@foar.unesp.br.
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: de Souza Costa
mesh_terms: D017607:Aluminum Compounds / Q000008:administration & dosage*; D000818:Animals; D001843:Bone Cements; D017610:Calcium Compounds / Q000008:administration & dosage*; D002126:Calcium Hydroxide / Q000008:administration & dosage*; D004338:Drug Combinations; D008297:Male; D010087:Oxides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials; D017640:Silicates / Q000008:administration & dosage*; D013977:Tibia / Q000187:drug effects* / Q000502:physiology
chemical_list: D017607:Aluminum Compounds; D001843:Bone Cements; D017610:Calcium Compounds; D004338:Drug Combinations; C557697:EndoBinder; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002126:Calcium Hydroxide
keywords: Bone repair; MTA; calcium aluminate cement; calcium hydroxide