title: Gene delivery by a cationic and thermosensitive nanogel promoted established tumor growth inhibition.
abstract: OBJECTIVE
  In vivo stability and consequent high tumor accumulation is highly desired for nonviral gene therapy.
  
  
  METHODS
  Here, a well-defined cationic nanogel system (NPS) was facilely prepared for gastric tumor therapy.
  
  
  RESULTS
  The physical chemical properties of NPS were finely regulated and investigated. In vitro transfer efficiency of NPS was obviously promoted due to stable polyplex structure, small size, narrow size distribution and weak surface potential. Interestingly, the transfection was further enhanced by its passive targeting function. Intratumor accumulation was significantly promoted post intravenous administrated to Balb/c nude mice. Thus, the established gastric tumor (N87) growth was significantly inhibited by p53 as delivered by NPS.
  
  
  CONCLUSIONS
  Such noncytotoxic cationic thermosensitive NPS can be effective for practicable gene therapy.
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Xudong
authors.initials: X
authors.lastname: Sun
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.affiliation: 3Department of Geriatric Neurology, Nanjing Medical University Affiliated to Nanjing Brain Hospital, Nanjing, Jiangsu, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Zhenquan
authors.initials: Z
authors.lastname: Song
authors.affiliation: 4International Joint Cancer Institute, Second Military Medical University, Shanghai, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: 1Department of Neurosurgery, Institute of Neurology, General Hospital of Shenyang Military Area Command, Shenyang, PR China.
authors.forename: Guobiao
authors.initials: G
authors.lastname: Liang
mesh_terms: D000818:Animals; D002412:Cations; D005260:Female; D005782:Gels; D018014:Gene Transfer Techniques; D064593:Heterografts; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D049329:Nanostructures
chemical_list: D002412:Cations; D005782:Gels
keywords: cancer therapy; gene delivery; nanotechnology; nonvirus vectors