title: Opinion: Addressing systemic problems in the biomedical research enterprise.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158; bruce.alberts@ucsf.edu.
authors.forename: Bruce
authors.initials: B
authors.lastname: Alberts
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA 02115;
authors.forename: Marc W
authors.initials: MW
authors.lastname: Kirschner
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, NJ 08540; and.
authors.forename: Shirley
authors.initials: S
authors.lastname: Tilghman
authors.affiliation: National Cancer Institute, Bethesda, MD 20892.
authors.forename: Harold
authors.initials: H
authors.lastname: Varmus
mesh_terms: D035843:Biomedical Research; D014481:United States