title: AMP-deaminase from thymus of patients with myasthenia gravis.
abstract: Myasthenia gravis (MG) is characterized clinically by skeletal muscle fatigue following the excessive exercise. Interestingly most of MG patients manifest parallely also some abnormalities of the thymus.AMP-deaminase (AMPD) from human thymus was not a subject of studies up to now. In this paper, mRNA expression and some physico-chemical and immunological properties of AMPD purified from the thymus of MG patients were described. Experiments performed identified the liver isozyme (AMPD2) as the main isoform of AMPD expressed in this organ. The activity of AMPD found in this organ was higher than in other human non-(skeletal) muscle tissues indicating on role the enzyme may play in supplying of guanylates required for the intensive multiplication of thymocytes.
authors.affiliation: a Department of Biochemistry and Clinical Physiology , Medical University of Gdansk , Gdansk , Poland.
authors.forename: I
authors.initials: I
authors.lastname: Rybakowska
authors.forename: M
authors.initials: M
authors.lastname: Szydłowska
authors.forename: S
authors.initials: S
authors.lastname: Szrok
authors.forename: S
authors.initials: S
authors.lastname: Bakuła
authors.forename: K
authors.initials: K
authors.lastname: Kaletha
mesh_terms: D000659:AMP Deaminase / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D004789:Enzyme Activation; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D013950:Thymus Gland / Q000201:enzymology* / Q000473:pathology
chemical_list: D000659:AMP Deaminase
keywords: AMP-deaminase; Myasthenia gravis; human thymus