title: Association of the late cornified envelope-3 genes with psoriasis and psoriatic arthritis: a systematic review.
abstract: Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (LCE) gene cluster, especially the cluster 3 (LCE3) genes. It is noteworthy that the deletion of LCE3B and LCE3C (LCE3C_LCE3B-del) is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future.
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
authors.forename: Changbing
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
authors.forename: Xianyong
authors.initials: X
authors.lastname: Yin
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
authors.forename: Liangdan
authors.initials: L
authors.lastname: Sun
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Institute and Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei 230032, China; Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Province, Hefei 230032, China; Department of Dermatology, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China. Electronic address: ayzxj@vip.sina.com.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000378:metabolism; D055233:Cornified Envelope Proline-Rich Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D004843:Epistasis, Genetic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D005810:Multigene Family; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins
keywords: LCE3 genes; Psoriasis; Psoriatic arthritis; Systematic review