title: [Ceftriaxone-induced immune haemolytic anaemia and multi-organ failure].
abstract: BACKGROUND
  Drug-induced immune haemolytic anaemia (DIIHA) is caused by various drugs or their metabolites. Cephalosporins are associated with haemolytic anaemia but multi-organ failure is rarely described.
  
  
  METHODS
  We report the case of a 57-year-old female who was diagnosed with neuroborreliosis and treated with ceftriaxone. The patient developed severe DIIHA. Massive intravascular haemolysis led to shock and acute renal failure, necessitating mechanical ventilation and dialysis. Treatment with ceftriaxone was discontinued and glucocorticoids were prescribed. The patient recovered slowly but fully.
  
  
  CONCLUSIONS
  Ceftriaxone-induced immune haemolytic anaemia is a rare but potentially fatal condition.
authors.affiliation: Radboudumc, afd. Anesthesiologie, Pijn- en Palliatieve Geneeskunde, Nijmegen.
authors.forename: Chantal E
authors.initials: CE
authors.lastname: Mulkens
authors.forename: Ellen G
authors.initials: EG
authors.lastname: van Lochem
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Folman
authors.forename: Ellen
authors.initials: E
authors.lastname: van der Spek
authors.forename: Henk J
authors.initials: HJ
authors.lastname: van Leeuwen
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D002443:Ceftriaxone