title: Effect of an advanced glycation end product-restricted diet and exercise on metabolic parameters in adult overweight men.
abstract: OBJECTIVE
  The aim of this study was to review the effect of a low advanced glycation end product (AGEs) diet, exercise, and a combination of both on circulating AGE levels as well as on plasma lipids and anthropometric parameters.
  
  
  METHODS
  Forty-three overweight or obese men (body mass index [BMI] >25 kg/m(2)), 30 to 55 y, participated in a 12-wk study and were randomly assigned to one of three groups: low AGE diet, exercise with habitual food intake, or exercise plus low AGE diet. Exercise was for 45 min at 65% to 75% of their maximum heart rate three times a week. We measured somatometric variables (BMI and waist circumference), blood glucose, lipids, and serum AGEs (N(ε)-[Carboxymethyl]Lysine [CML] and methylglyoxal [MG]) at baseline and at 12 wk.
  
  
  RESULTS
  Exercise alone was associated with decreased somatometric variables; the low AGE diet had the same effects and decreased serum CML and MG and when combined with exercise reproduced all these effects, but also decreased triacylglycerols and increased high-density lipoprotein. Correlation analysis showed that both changes of CML and MG correlated with changes in dietary AGEs (P < 0.020 and P < 0.038, respectively); change in maximum oxygen consumption correlated inversely with change in weight and triacylglycerols. Regression analyses, including change in dietary AGEs and in dietary calories, showed that change in dietary AGEs was the independent determinant of change in CML (P < 0.020) and MG (P < 0.038).
  
  
  CONCLUSIONS
  An AGE-restricted diet reduces serum AGE and indices of body fat. The addition of exercise to the restricted diet has the same effects but also improves lipid profile.
authors.affiliation: Departamento de Ciencias Médicas, Universidad Guanajuato, Campus León, Guanajuato, Mexico.
authors.forename: Maciste Habacuc
authors.initials: MH
authors.lastname: Macías-Cervantes
authors.affiliation: Departamento de Ciencias Médicas, Universidad Guanajuato, Campus León, Guanajuato, Mexico.
authors.forename: Juana María Dolores
authors.initials: JM
authors.lastname: Rodríguez-Soto
authors.affiliation: Department of Medicine, The Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
authors.affiliation: Departamenot de Ciencias aplicadas al Trabajo, Universidad Guanajuato, Campus León, Guanajuato, Mexico.
authors.forename: Francisco José
authors.initials: FJ
authors.lastname: Díaz-Cisneros
authors.affiliation: Department of Geriatrics, The Mount Sinai Health System, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Weijingi
authors.initials: W
authors.lastname: Cai
authors.affiliation: Departamento de Ciencias Médicas, Universidad Guanajuato, Campus León, Guanajuato, Mexico. Electronic address: marugaray_2000@yahoo.com.
authors.forename: Ma Eugenia
authors.initials: ME
authors.lastname: Garay-Sevilla
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004032:Diet; D004038:Diet, Reducing; D002149:Energy Intake; D015444:Exercise; D005247:Feeding Behavior; D017127:Glycation End Products, Advanced / Q000008:administration & dosage* / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D050177:Overweight; D010101:Oxygen Consumption; D011765:Pyruvaldehyde / Q000097:blood; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D008055:Lipids; D008075:Lipoproteins, HDL; D014280:Triglycerides; C048496:N(6)-carboxymethyllysine; D011765:Pyruvaldehyde; D008239:Lysine
keywords: Advanced glycation end products; Exercise; Overweight men