title: [Smart choice between two DNA double-strand break repair mechanisms].
abstract: DNA double-strand break (DSB) is considered most deleterious among radiation-induced DNA damages and most relevant to the biological effects of radiation. In eukaryotic cells, DSB is repaired mainly through two pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). These repair pathways seem to play complementary roles. NHEJ is considered less accurate than HR, but HR is available only in late S and G2 phases in vertebrates. Recent studies elucidated how cells choose one from these two pathways depending on the circumstance: cell cycle phase, complexity of DNA damage and chromatin structure.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Matsumoto
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D017766:Acid Anhydride Hydrolases; D000818:Animals; D034961:Antigens, Nuclear / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D002843:Chromatin; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D059766:DNA End-Joining Repair / Q000235:genetics* / Q000502:physiology*; D045643:DNA Repair Enzymes / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D016195:G2 Phase / Q000235:genetics / Q000502:physiology; D006801:Humans; D000072200:Ku Autoantigen; D000076228:MRE11 Homologue Protein; D051379:Mice; D009687:Nuclear Proteins / Q000502:physiology; D011853:Radiobiology; D059767:Recombinational DNA Repair / Q000235:genetics* / Q000502:physiology*; D016196:S Phase / Q000235:genetics / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology
chemical_list: D018528:ATP-Binding Cassette Transporters; D017766:Acid Anhydride Hydrolases; D034961:Antigens, Nuclear; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D002843:Chromatin; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D000072200:Ku Autoantigen; D000076228:MRE11 Homologue Protein; D009687:Nuclear Proteins; C501070:RBBP8 protein, mouse; C512689:Mre11a protein, mouse; C466108:Nijmegen breakage syndrome 1 protein, mouse; C495198:Rad50 protein, mouse; C000606509:Xrcc6 protein, human; C000606510:Xrcc6 protein, mouse