title: Nickel-catalyzed three-component domino reactions of aryl Grignard reagents, alkynes, and aryl halides producing tetrasubstituted alkenes.
abstract: Three-component reaction of aryl Grignard reagents, alkynes, and aryl halides in the presence of 1 mol % of NiCl2 proceeded sequentially through carbomagnesiation of the alkyne followed by cross-coupling of the resulting alkenyl Grignard reagent with aryl halide to give tetrasubstituted alkenes in high yields.
authors.affiliation: Department of Chemistry, National University of Singapore , Singapore 117543, Singapore.
authors.forename: Fei
authors.initials: F
authors.lastname: Xue
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: T S Andy
authors.initials: TS
authors.lastname: Hor
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; C022838:nickel chloride; D009532:Nickel