title: Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum.
abstract: We looked for mutations in the Plasmodium falciparum K13 propeller gene of an artemisinin-resistant parasite on islands in Lake Victoria, Kenya, where transmission in 2012-2013 was high. The 4 new types of nonsynonymous, and 5 of synonymous, mutations we detected among 539 samples analyzed provide clues to understanding artemisinin-resistant parasites.
authors.forename: Rie
authors.initials: R
authors.lastname: Isozumi
authors.forename: Haruki
authors.initials: H
authors.lastname: Uemura
authors.forename: Isao
authors.initials: I
authors.lastname: Kimata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ichinose
authors.forename: John
authors.initials: J
authors.lastname: Logedi
authors.forename: Ahmeddin H
authors.initials: AH
authors.lastname: Omar
authors.forename: Akira
authors.initials: A
authors.lastname: Kaneko
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D037621:Artemisinins / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D004351:Drug Resistance / Q000235:genetics; D005843:Geography; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology*; D009154:Mutation; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D037621:Artemisinins; D015800:Protozoan Proteins; C031327:artemisinin