title: Ultrasound findings in fetal congenital heart block associated with maternal anti-Ro/SSA and Anti-La/SSB antibodies.
abstract: We present the sonographic features of a second-trimester fetus diagnosed with a bradyarrhythmia at 19 weeks' gestation. The mother carried a diagnosis of Sjögren syndrome, including the presence of SSA and SSB antibodies. Ultrasound M-mode and fetal echocardiogram revealed the etiology of the bradycardia to be a complete fetal congenital heart block, likely due to transplacental passage of autoimmune anti-Ro/SSA and anti-La/SSB antibodies. Consequential to the congenital heart block, the fetus developed hydrops fetalis at 21 weeks' gestational age. We discuss the 2 major etiologies of congenital heart block and the implications in subsequent pregnancies.
authors.affiliation: *Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and †Division of Body Imaging, Department of Radiology, University of Washington, Medical Center, Seattle, WA; and ‡Department of Radiology, University of California, San Diego Medical Center, San Diego, CA.
authors.forename: Jasmine
authors.initials: J
authors.lastname: Lai
authors.forename: Toshi J
authors.initials: TJ
authors.lastname: Clark
authors.forename: Justin H
authors.initials: JH
authors.lastname: Tan
authors.forename: Shani
authors.initials: S
authors.lastname: Delaney
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Jolley
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000276:immunology; D006327:Heart Block / Q000151:congenital* / Q000000981:diagnostic imaging / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000000981:diagnostic imaging* / Q000276:immunology*; D016216:Ultrasonography, Prenatal / Q000379:methods
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies