title: [HDL cholesterol and high-sensitive troponin T as predictive biomarkers of atrial fibrillation after heart surgery].
abstract: BACKGROUND
  Atrial fibrillation (AF) has an incidence rate of approximately 30% and is the most frequent arrhythmia following heart surgery. Factors such as inflammation, the presence of heart fibrosis, stress and cardiomyocyte apoptosis, have all been associated with AF.
  
  
  OBJECTIVE
  We believe that atrial remodelling is a pre-existent process in patients with post-surgical AF. We have analyzed the factors related to the incidence of atrial fibrillation in the period after heart surgery.
  
  
  METHODS
  We included consecutive, hemodynamically stable patients with a sinusal rhythm who were subjected to programmed heart surgery with extracorporeal circulation. An assessment was made of the fall in atrial fibrillation after surgery using prolonged electrocardiographic monitoring.
  
  
  RESULTS
  A total of 100 patients were included in the study and were subjected to either coronary revascularisation surgery (59) or aortic valve substitution due to severe aortic stenosis (41). Postoperative AF occurred in 29 patients who received predominantly more valve surgery than coronary surgery. The following factors were predictive of postoperative AF in the multivariate analysis: Male sex; beta-blocker therapy for chronic disease; the use of intraoperative; fibrinogen perfusion; low HDL cholesterol values; and high sensitive troponin T values, in the preoperative period.
  
  
  CONCLUSIONS
  HDL cholesterol and high sensitive troponin T can be useful biomarkers to predict the occurrence of AF after surgery. The early identification of these patients who develop of FA allows us to take preventive measures to minimize the negative effects.
authors.affiliation: Servicio de Cirugía Torácica y Cardiovascular, Hospital Universitario Jean Minjoz, Besançon, Francia. Electronic address: alt92a@yahoo.es.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Lahoz-Tornos
authors.affiliation: Servicio de Análisis Clínicos, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Vilchez-Aguilera
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Diana
authors.initials: D
authors.lastname: Hernandez-Romero
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Romero-Aniorte
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Esteban
authors.initials: E
authors.lastname: Orenes-Piñero
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Ruben
authors.initials: R
authors.lastname: Jara-Rubio
authors.affiliation: Unidad de Cuidados Intensivos, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Ana
authors.initials: A
authors.lastname: Del Saz-Ortiz
authors.affiliation: Servicio de Cirugía Cardiovascular, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: José María
authors.initials: JM
authors.lastname: Arribas-Leal
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Arcadio
authors.initials: A
authors.lastname: García-Alberola
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Mariano
authors.initials: M
authors.lastname: Valdés-Chávarri
authors.affiliation: Servicio de Cardiología, Hospital Universitario Virgen de la Arrixaca, Murcia, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín-Ortuño
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D006348:Cardiac Surgical Procedures; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood*; D011237:Predictive Value of Tests; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D020107:Troponin T
keywords: Atrial fibrillation; Circulación extracorpórea; Cirugía cardiaca; España; Extracorporeal circulation; Fibrilación auricular; Heart surgery; Spain