title: Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions.
abstract: Elucidation of molecular mechanisms underlying host-pathogen interactions is important for control and treatment of infectious diseases worldwide. Within the last decade, mass spectrometry (MS)-based proteomics has become a powerful and effective approach to better understand complex and dynamic host-pathogen interactions at the protein level. Herein we will review the recent progress in proteomic analyses towards bacterial infection of their mammalian host with a particular focus on enteric pathogens. Large-scale studies of dynamic proteomic alterations during infection will be discussed from the perspective of both pathogenic bacteria and host cells.
authors.affiliation: Institute of Analytical Chemistry and Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
authors.forename: Yufei
authors.initials: Y
authors.lastname: Yang
authors.forename: Mo
authors.initials: M
authors.lastname: Hu
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Yu
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Zeng
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000382:microbiology* / Q000473:pathology; D001426:Bacterial Proteins / Q000302:isolation & purification* / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D013058:Mass Spectrometry; D011499:Protein Processing, Post-Translational; D040901:Proteomics
chemical_list: D001426:Bacterial Proteins