title: Cyclometallated gold(III) aryl-pyridine complexes as efficient catalysts for three-component synthesis of substituted oxazoles.
abstract: Cyclometallated aryl-pyridine gold(iii) complexes are shown to be efficient catalysts for the multicomponent reaction between N-benzyl imines, alkynes, and acyl chlorides to form trisubstituted oxazoles. The reaction typically proceeds in good yields (up to over 80%) and short reaction times (∼15 minutes). The high stability of the investigated cyclometallated catalysts enables a retained efficiency for this reaction in terms of rate and yield using as little as 0.5 mol% catalyst, a reduction by an order of magnitude compared to previously used Au(iii)-salen complexes. An attractive feature of the present catalytic system is that active catalysts can be formed from simple pre-catalysts under the reaction conditions. Both cyclometallated and non-cyclometallated complexes were characterized in the solid state by single crystal X-ray diffraction.
authors.affiliation: Centre for Analysis and Synthesis, Department of Chemistry, Lund University, Box 124, 221 00 Lund, Sweden. daniel.strand@chem.lu.se.
authors.forename: Henrik
authors.initials: H
authors.lastname: von Wachenfeldt
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Polukeev
authors.forename: Nagarajan
authors.initials: N
authors.lastname: Loganathan
authors.forename: Filip
authors.initials: F
authors.lastname: Paulsen
authors.forename: Philipp
authors.initials: P
authors.lastname: Röse
authors.forename: Marion
authors.initials: M
authors.lastname: Garreau
authors.forename: Ola F
authors.initials: OF
authors.lastname: Wendt
authors.forename: Daniel
authors.initials: D
authors.lastname: Strand