title: An oral redox-sensitive self-immolating prodrug strategy.
abstract: We report a novel oral prodrug approach where a solubilizing polymer conjugated to the drug is designed to be released by the action of an exogenously administered agent in the intestine. A redox-sensitive self-immolating design was implemented, and the reconversion kinetics were studied for three reducible prodrugs.
authors.affiliation: Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland. jleroux@ethz.ch.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Andrea
authors.initials: A
authors.lastname: Morger
authors.forename: Bastien
authors.initials: B
authors.lastname: Castagner
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Leroux
mesh_terms: D000284:Administration, Oral; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry; D011355:Prodrugs / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility
chemical_list: D011108:Polymers; D011355:Prodrugs