title: B(12)-mediated, long wavelength photopolymerization of hydrogels.
abstract: Medical hydrogel applications have expanded rapidly over the past decade. Implantation in patients by noninvasive injection is preferred, but this requires hydrogel solidification from a low viscosity solution to occur in vivo via an applied stimuli. Transdermal photo-cross-linking of acrylated biopolymers with photoinitiators and lights offers a mild, spatiotemporally controlled solidification trigger. However, the current short wavelength initiators limit curing depth and efficacy because they do not absorb within the optical window of tissue (600-900 nm). As a solution to the current wavelength limitations, we report the development of a red light responsive initiator capable of polymerizing a range of acrylated monomers. Photoactivation occurs within a range of skin type models containing high biochromophore concentrations.
authors.affiliation: Department of Chemistry, ‡Division of Chemical Biology and Medicinal Chemistry, and § Department of Pharmacology, University of North Carolina , Chapel Hill, North Carolina 27599, United States.
authors.forename: Zachary L
authors.initials: ZL
authors.lastname: Rodgers
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hughes
authors.forename: Laura M
authors.initials: LM
authors.lastname: Doherty
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Shell
authors.forename: Brian P
authors.initials: BP
authors.lastname: Molesky
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Brugh
authors.forename: Malcolm D E
authors.initials: MD
authors.lastname: Forbes
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Moran
authors.forename: David S
authors.initials: DS
authors.lastname: Lawrence
mesh_terms: D000179:Acrylates / Q000737:chemistry; D002470:Cell Survival; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008027:Light; D008422:Materials Testing / Q000379:methods*; D008543:Melanins / Q000737:chemistry; D010777:Photochemistry / Q000379:methods*; D010782:Photolysis; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011407:Propane / Q000031:analogs & derivatives / Q000737:chemistry; D012867:Skin; D014805:Vitamin B 12 / Q000737:chemistry*
chemical_list: C499598:2-hydroxy-1-(4-(hydroxyethoxy)phenyl)-2-methyl-1-propanone; D000179:Acrylates; D020100:Hydrogels; D008543:Melanins; D011092:Polyethylene Glycols; D014805:Vitamin B 12; D011407:Propane