title: Argan oil reduces, in rats, the high fat diet-induced metabolic effects of obesity.
abstract: OBJECTIVE
  Obesity is a multi-factorial disorder which is of worldwide concern. In addition to calorie control, some specific dietary components might help resolving some of the complication of obesity, by providing antioxidant and anti-inflammatory activities. We investigated the effect of argan oil supplementation on plasma lipid profile and oxidant-antioxidant status of rats with high-fat diet (HFD)-induced obesity compared with rats fed a normal diet (ND).
  
  
  RESULTS
  We used an animal model of high fat diet-induced obesity to study the metabolic effects of argan oil and we measured several markers lipid and redox statuses. Consumption of a high-fat diet led to an increase in serum total cholesterol (TC), LDL-cholesterol (LDL-C), and triacylglycerols (TAG) concentrations; however, argan oil blunted the increases of TC, LDL-C and TG, glucose, and insulin. Plasma total antioxidant capacity, erythrocyte catalase and superoxide dismutase activities were lower, whereas plasma hydroperoxide, thiobarbituric acid-reacting substances, and susceptibility of LDL to copper-induced oxidation were higher in obese rats compared with normal rats. Administration of argan oil ameliorated all these indices of redox status.
  
  
  CONCLUSIONS
  Proper diet and lifestyle should be foremost implemented to reduce the lipoprotein metabolism and oxidant/antioxidant status alterations brought about by obesity. In addition, argan oil reduces the metabolic effects of obesity and its use might be promoted within the context of a balanced diet.
authors.affiliation: Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Sour
authors.affiliation: Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Belarbi
authors.affiliation: Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Sari
authors.affiliation: Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
authors.forename: C H
authors.initials: CH
authors.lastname: Benammar
authors.affiliation: Laboratoire des produits naturels, Faculté des sciences de la nature et de la vie et des sciences de la terre et de la vie, Université de Tlemcen, Algeria.
authors.forename: C H
authors.initials: CH
authors.lastname: Baghdad
authors.affiliation: Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM+CSIC, Madrid, Spain; Department of Molecular Medicine, University of Padova, Viale G, Colombo 3, 35121 Padova, Italy. Electronic address: francesco.visioli@unipd.it.
authors.forename: F
authors.initials: F
authors.lastname: Visioli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D002149:Energy Intake; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D018384:Oxidative Stress; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D020738:Leptin; D010938:Plant Oils; D014280:Triglycerides; C555574:argan oil
keywords: Argan oil; High-fat diet; Insulin; Leptin; Obesity; Oxidant/antioxidant status