title: Direct trifluoromethylthiolation of unactivated C(sp(3))-H using silver(I) trifluoromethanethiolate and potassium persulfate.
abstract: A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp(3) )H bonds by AgSCF3 /K2 S2 O8 under mild conditions is described. The reaction has a good functional-group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K2 S2 O8 plays key roles in both the activation of the C(sp(3) )H bond and the oxidation of AgSCF3 .
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032, Shanghai (China).
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Xiao
authors.forename: Junhui
authors.initials: J
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.forename: Ji-Chang
authors.initials: JC
authors.lastname: Xiao
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Chen
mesh_terms: D034242:Cyclooctanes / Q000737:chemistry; D007202:Indicators and Reagents; D007700:Kinetics; D008745:Methylation; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D017680:Potassium Compounds / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis*
chemical_list: D034242:Cyclooctanes; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D017680:Potassium Compounds; D013431:Sulfates; D013438:Sulfhydryl Compounds; C009007:potassium persulfate; C474479:cyclooctane
keywords: CH activation; fluorine; radical reactions; synthetic methods; trifluoromethylthiolation