title: Iron-catalyzed oxidative biaryl cross-couplings via mixed diaryl titanates: significant influence of the order of combining aryl Grignard reagents with titanate.
abstract: The mixed diaryl titanates were used for the first time to modify the reactivity of two aryl Grignard reagents. Two titanate intermediates, Ar[Ar'Ti(OR)3]MgX and Ar'[ArTi(OR)3]MgX, formed via alternating the sequence of combining Grignard reagents with ClTi(OR)3 showed a significant reactivity difference. Taking advantage of such different reactivity, two highly structurally similar aryl groups could be facilely assembled through iron-catalyzed oxidative cross-couplings using oxygen as the oxidant.
authors.affiliation: College of Chemistry, Beijing Normal University, Beijing, 100875, China. xinfangduan@vip.163.com.
authors.forename: Kun Ming
authors.initials: KM
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Wei
authors.forename: Xin Fang
authors.initials: XF
authors.lastname: Duan