title: Identification and management of atypical hemolytic uremic syndrome immediately post-heart transplantation.
abstract: Atypical hemolytic uremic syndrome (aHUS) is a serious hematologic disorder with high mortality if left untreated. A comprehensive literature review revealed only two cases of aHUS post-heart transplantation. In both cases the disease developed after induction of calcineurin inhibitor therapy. We report a case of immediate post-heart transplantation aHUS, manifested before the induction of, and therefore not associated with, calcineurin inhibitors.
authors.affiliation: Department of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Panos N
authors.initials: PN
authors.lastname: Vardas
authors.forename: Zubair A
authors.initials: ZA
authors.lastname: Hashmi
authors.forename: M Azam
authors.initials: MA
authors.lastname: Hadi
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized; D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis* / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D065095:Calcineurin Inhibitors; D003404:Creatinine / Q000097:blood; D003956:Dialysis; D042241:Early Diagnosis; D005260:Female; D006242:Haptoglobins; D016027:Heart Transplantation; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010951:Plasma Exchange; D010976:Platelet Count; D011183:Postoperative Complications / Q000175:diagnosis* / Q000628:therapy*; D016559:Tacrolimus; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; D065095:Calcineurin Inhibitors; D006242:Haptoglobins; C481642:eculizumab; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D016559:Tacrolimus