title: Primary pleomorphic rhabdomyosarcoma of breast: Report of a rare neoplasm.
abstract: Primary sarcoma of the breast is very rare and constitutes less than 1% of all breast cancers. Herein, we report a case of pleomorphic rhabdomyosarcoma (PRMS) of the right breast in a 49-year-old female patient presented with a mass (7 cm × 6.5 cm). Mammography and ultrasonography suspected a malignant lesion and a diagnosis of poorly differentiated carcinoma was made on fine needle aspiration cytology. Modified radical mastectomy was carried out. Histopathological examination revealed a high grade stromal sarcoma with rhabdoid morphology and multinucleated tumor giant cells. The tumor cells were strongly positive for desmin, vimentin and Myo D1 focally. The tumor cells were immunonegative for cytokeratin, epithelial membrane antigen (EMA), CD34, CD45, SMA, S100, CD68 and HMB45. A final diagnosis of PRMS was rendered. Surgical margins were free and no metastasis was seen in axillary lymph nodes. Neither post-operative radiotherapy nor adjuvant chemotherapy was given and the patient has remained disease free 12 months post-operatively.
authors.affiliation: Department of Pathology, Medical College, Kolkata, West Bengal, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Mondal
authors.affiliation: Department of Pathology, Medical College, Kolkata, West Bengal, India.
authors.forename: Palash Kumar
authors.initials: PK
authors.lastname: Mandal
authors.affiliation: Department of Pathology, Medical College, Kolkata, West Bengal, India.
authors.forename: Anindya
authors.initials: A
authors.lastname: Adhikari
authors.affiliation: Department of Pathology, Medical College, Kolkata, West Bengal, India.
authors.forename: Bijan
authors.initials: B
authors.lastname: Basak
keywords: Breast; pleomorphic; primary sarcoma; rhabdomyosarcoma