title: The topical corticosteroid classification called into question: towards a new approach.
abstract: Vasoconstrictor assay described in 1962 was an interesting assessment of potency of topical corticosteroids at the beginning of these new therapies, however knowledge and technology have evolved and the classification should follow. A topical corticosteroids with a strong vasoconstrictor effect, as determined by vasoconstrictor assay, has not necessary a strong anti-inflammatory effect. Therefore a specific classification adapted to the therapeutic target is needed to be more efficient and thus reduce side effects and corticophobia.
authors.affiliation: Research and Studies Center on the Integument (CERT), Department of Dermatology, Clinical Investigation Center (CIC INSERM 1431), Besançon University Hospital, Besançon, France; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Humbert
authors.forename: Alexandre
authors.initials: A
authors.lastname: Guichard
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000145:classification* / Q000493:pharmacokinetics; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000145:classification* / Q000493:pharmacokinetics; D006801:Humans; D012871:Skin Diseases / Q000188:drug therapy; D013810:Therapeutic Equivalency; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D000305:Adrenal Cortex Hormones; D003879:Dermatologic Agents
keywords: classification; potency; topical corticosteroid; vasoconstrictor assay