title: Silver-mediated oxidative aliphatic C-H trifluoromethylthiolation.
abstract: The first example of a practical and direct trifluoromethylthiolation reaction of unactivated aliphatic CH bonds employs a silver-based reagent. The reaction is operationally simple, scalable, and proceeds under aqueous conditions in air. Furthermore, its broad scope and good functional-group compatibility were demonstrated by applying this method to the selective trifluoromethylthiolation of natural products and natural-product derivatives.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071 (China).
authors.forename: Shuo
authors.initials: S
authors.lastname: Guo
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.forename: Pingping
authors.initials: P
authors.lastname: Tang
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001688:Biological Products / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D018030:Silver Compounds / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis*
chemical_list: D000596:Amino Acids; D001688:Biological Products; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D018030:Silver Compounds; D013431:Sulfates; D013438:Sulfhydryl Compounds; C012036:sodium sulfate
keywords: CH activation; fluorine; radicals; synthetic methods; trifluoromethylthiolation