title: Should we use the serum vaspin level for the diagnosis and/or prognosis of subarachnoid hemorrhage?
abstract: BACKGROUND
  We aimed to investigate whether vaspin, a member of the serine protease family, could be used as a marker for the severity and prognosis of subarachnoid hemorrhage (SAH).
  
  
  METHODS
  Fifty-two consecutive patients (mean age, 51.46±3.2 years; 61.5% male) admitted to the emergency service of our hospital and hospitalized at our clinic with the diagnosis of aneurysmal SAH between 2012 and 2014 were included in the study and followed up for six months for outcome. The control group consisted of 52 healthy individuals of similar age and gender.
  
  
  RESULTS
  During the 6-month follow-up, 8 of 52 patients died, and 18 (34.6%) patients had poor the Glasgow Outcome Score (GOS) scores. In 20 (38.46%) patients, acute hydrocephalus developed, and external ventricular drainage was performed. In the study group, the mean vaspin level was significantly higher than control group (157.88±33.6 pg/mL and 109.59±45.68 pg/mL, respectively; P<0.01). The mean vaspin level was 215.18±12.36 pg/mL in the non-survival group and 147.47±24.43 pg/mL in the survival group. Furthermore, it was 195.99±21.10 pg/mL in patients with poor outcome in terms of GOS, and 137.71±17.61 pg/mL in those with good outcome. The vaspin levels significantly increased with worsening of GOS, the World Federation of Neurological Surgeons (WFNS) grading system, and Fisher scores and increasing plasma C-reactive protein levels (P<0.01 for all).
  
  
  CONCLUSIONS
  In conclusion, vaspin can play a role as a new marker in the diagnosis, severity assessment, and prognosis of SAH.
authors.affiliation: Department of Neurosurgery, Ataturk University Faculty of Medicine, Erzurum, Turkey - dr.cagatay33@gmail.com.
authors.forename: Cagatay
authors.initials: C
authors.lastname: Calikoglu
authors.affiliation: Department of Neurosurgery, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Murteza
authors.initials: M
authors.lastname: Cakir
authors.affiliation: Department of Biochemistry, Ataturk University Faculty of Pharmacy, Erzurum, Turkey.
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Kutlu Kotan
authors.affiliation: Department of Neurology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozdemir
authors.affiliation: Department of Neurology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Lutfi
authors.initials: L
authors.lastname: Özel
authors.affiliation: Department of Pharmacology, Ataturk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Irmak
authors.initials: I
authors.lastname: Ferah
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015843:Serpins / Q000097:blood*; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; C507339:SERPINA12 protein, human; D015843:Serpins