title: An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML.
abstract: We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a molecular marker in elderly for consideration of aggressive treatment, even if abridged, as this subset may achieve a durable, good quality responses at diagnosis or subsequent relapses.
authors.affiliation: Specialist Registrar in Haematology, Department of Haematology, Level 3 Bexley Wing, St. James׳s University Hospital, Leeds LS9 7TF, United Kingdom.
authors.forename: Srivasavi
authors.initials: S
authors.lastname: Dukka
authors.affiliation: Honorary Professor of Myeloid Leukaemia Studies and Consultant Haematologist, St James׳s Institute of Oncology, Bexley Wing, Beckett Street, Leeds LS9 7TF, United Kingdom.
authors.forename: David T
authors.initials: DT
authors.lastname: Bowen
keywords: Intensive chemotherapy; NK AML in elderly; NPM1 mutation