title: [Molecular and cellular mechanisms of depression. Role of glucocorticoids, cytokines, neurotransmitters, and trophic factors in genesis of depressive disorders].
abstract: Here we review modern data on appearance and maintenance of depression at different levels of the body. We discuss a role of impairments of emotional and motivation mechanisms of adaptive behavior in genesis of depression. We demonstate an interaction of stress response and neuroinflammatory processes in pathogenesis of depression and analyze the effects of these molecular cascades on neurotrophic support of the central mechanisms of memory and neurogenesis.
authors.forename: G A
authors.initials: GA
authors.lastname: Grigor'ian
authors.forename: N N
authors.initials: NN
authors.lastname: Dygalo
authors.forename: A B
authors.initials: AB
authors.lastname: Gekht
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Stepanichev
authors.forename: N V
authors.initials: NV
authors.lastname: Guliaeva
mesh_terms: D000223:Adaptation, Psychological; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D016207:Cytokines / Q000276:immunology*; D003863:Depression / Q000209:etiology* / Q000276:immunology / Q000378:metabolism / Q000523:psychology; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D008568:Memory / Q000502:physiology; D009414:Nerve Growth Factors / Q000378:metabolism*; D015213:Neuroimmunomodulation; D009473:Neuronal Plasticity; D009435:Synaptic Transmission
chemical_list: D015306:Biogenic Monoamines; D016207:Cytokines; D005938:Glucocorticoids; D009414:Nerve Growth Factors