title: Influence of de novo donor-specific antibody on early renal allograft function recovery.
abstract: BACKGROUND
  The aim of the present study is to investigate the impact of de novo donor-specific antibodies (dnDSA) on early graft function, to provide objective reference for early clinical diagnosis and reasonable individualized treatment.
  
  
  METHODS
  305 cases of renal transplant patients for the first time were observed in this study. Follow-up time for all recipients was 6 months after operation. HLA antibody, DSA, renal function were monitored after transplant.
  
  
  RESULTS
  In total of 305 cases, 66 cases (21.64%) were HLA antibody positive and 21 cases (6.89%) showed acute rejection (AR) in 6 months after transplant. The HLA antibody-positive patients included six cases of dnDSA-positive and 60 cases of dnDSA-negative. The incidence of AR was 2.09% (5/239) in HLA antibody-negative patients, 18.33% (11/60) in HLA antibody positive with DSA-negative patients, and 83.33% (5/6) in HLA antibody-positive patients with DSA-positive. There was a big difference between DSA-negative and DSA-positive patients (p < 0.01). The recovery time of AR patients with DSA-positive were longer than DSA-negative patients, and the recovery graft function of AR patient with DSA-positive were not as good as those with DSA-negative.
  
  
  CONCLUSIONS
  The appearance of dnDSA in the early stage of kidney transplantation is a warning sign of AR occurrence. Dynamic monitoring of HLA antibody and DSA could predict the state of graft function, and play an important role in the prevention of AR, timely and effectively.
authors.affiliation: Institute of Organ Transplantation, School of Medicine College, Xi'an Jiaotong University , Xi'an , China and.
authors.forename: Jin
authors.initials: J
authors.lastname: Zheng
authors.forename: Wujun
authors.initials: W
authors.lastname: Xue
authors.forename: Xin
authors.initials: X
authors.lastname: Jing
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Tian
authors.forename: Puxun
authors.initials: P
authors.lastname: Tian
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Ding
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Pan
authors.forename: Hang
authors.initials: H
authors.lastname: Yan
authors.forename: Xinshun
authors.initials: X
authors.lastname: Feng
authors.forename: Heli
authors.initials: H
authors.lastname: Xiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Chenguang
authors.initials: C
authors.lastname: Ding
mesh_terms: D000328:Adult; D002681:China; D051799:Delayed Graft Function / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000601:surgery; D007677:Kidney Function Tests / Q000379:methods; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D015166:Monitoring, Immunologic / Q000379:methods; D011379:Prognosis; D020127:Recovery of Function / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies
keywords: ABMR; DSA; HLA antibody; NDSA; renal transplant