title: Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy.
abstract: Wnt/β-catenin and Hedgehog/Gli signalings play key roles in multiple biogenesis such as embryonic development and tissue homeostasis. Dysregulations of these 2 pathways are frequently found in most cancers, particularly in colon cancer. Their crosstalk has been increasingly appreciated as an important mechanism in regulating colon cancer progression. Our studies into the link between Wnt/β-catenin and Hedgehog/Gli signalings in colon cancer revealed several possible crosstalk points and suggested potential therapeutic strategies for colon cancer.
authors.affiliation: a MOE Key Lab of Environmental Remediation and Ecosystem Health; College of Environmental and Resource Sciences; Zhejiang University ; Hangzhou , China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.forename: Zhuo-Yu
authors.initials: ZY
authors.lastname: Li
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Mei-Rong
authors.initials: MR
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D015513:Oncogene Proteins / Q000378:metabolism*; D011485:Protein Binding; D015398:Signal Transduction / Q000187:drug effects; D015534:Trans-Activators / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D000071676:Zinc Finger Protein GLI1; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D053823:Hedgehog Proteins; D015513:Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D000071676:Zinc Finger Protein GLI1; D051176:beta Catenin
keywords: Gli; Hedgehog/Gli signaling; Wnt/β-catenin signaling; colon cancer; crosstalk; therapeutic targets; β-catenin