title: A new approach in DCE MRI data analysis for differentiating benign and malignant breast lesions.
abstract: BACKGROUND
  Dynamic contrast enhanced MRI (DCE MRI) is able to reflect changes in vascularity, vessel permeability and extracellular diffusion space of tissues. The goal of this study was to investigate the use of DCE MRI to differentiate benign and malignant breast lesions.
  
  
  METHODS
  From a database, five patients with malignant and five patients with benign lesions were randomly chosen. All patients underwent measurement in a 3T MR scanner using a breast coil. A series of T1-weighted MRI were performed using an intravenously delivered contrast agent. Then, 17 postcontrast sets were acquired within a timeframe of 13 seconds. All DCE MRI data were evaluated using the JIM image analysis package. We observed changes in signal intensity over the acquisition time -  curves of dynamic contrast enhancement.
  
  
  CONCLUSIONS
  We investigated parts of the curves with the largest increase in signal intensity during the timeframe. For further comparison, we used values of the highest signal intensity increases between the timeframes. Analysis of these results led to the proposal that the threshold between benign and malignant lesion had a relative value of 100. Furthermore, there was a significant difference between these two types of lesions.
authors.forename: P
authors.initials: P
authors.lastname: Hnilicova
authors.forename: T
authors.initials: T
authors.lastname: Jaunky
authors.forename: E
authors.initials: E
authors.lastname: Baranovicova
authors.forename: E
authors.initials: E
authors.lastname: Heckova
authors.forename: D
authors.initials: D
authors.lastname: Dobrota
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media