title: Fusarium falciforme infection in a patient with chronic granulomatous disease: Unique long-term course of epidural abscess.
abstract: Chronic granulomatous disease (CGD) is a primary immunodeficiency disease characterized by recurrent life-threatening bacterial and fungal infections with granuloma formation. Species of the genus Fusarium are opportunistic environmental microorganisms that are rarely pathogenic in humans. We report here the first case of X-linked CGD complicated with epidural abscess caused by Fusarium falciforme infection. The abscesses extended along the dura mater for >7 years and finally resulted in fatal meningitis and cervical myelitis. Early intervention with hematopoietic stem cell transplantation should be considered, especially in patients with severe CGD, before the development of serious infectious complication.
authors.affiliation: Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okura
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kawamura
authors.forename: Motohiko
authors.initials: M
authors.lastname: Okano
authors.forename: Nariaki
authors.initials: N
authors.lastname: Toita
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Takezaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yamada
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kobayashi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
mesh_terms: D000293:Adolescent; D020802:Epidural Abscess / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D005500:Follow-Up Studies; D005670:Fusarium / Q000302:isolation & purification*; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D009181:Mycoses / Q000150:complications* / Q000382:microbiology; D013997:Time Factors
keywords: Fusarium; chronic granulomatous disease; epidural abscess; meningitis; myelitis