title: [Evoked retinal and cortical potentials in children with advanced and resistant retinoblastoma after neoadjuvant polychemotherapy and superselective intra-arterial chemotherapy].
abstract: Electrophysiological examinations (in accordance with the ISCEV Standards and original protocols) were performed after neoadjuvant chemotherapy or before and after superselective intra-arterial chemotherapy (SIACT) in 18 children aged 1-3 years with either newly diagnosed advanced retinoblastoma (8 eyes) or resistant retinoblastoma (14 eyes). The most considerable decrease in amplitude was demonstrated by the cone response b-wave, photopic 24 Hz flicker electroretinogram (ERG), photopic negative response, and the P1-component of multifocal ERG, indicating a significant dysfunction of bipolar and ganglion cells, more pronounced in the macular zone. After the SIACT, central retinal functions improved. In eyes with retinoblastoma there is a moderate peak latency shortening of the flash visual evoked potential (VEP) P2-component, which reflects functional changes in the central retina rather than those in the visual pathways, and therefore, flash VEP analysis is a useful tool of chemotherapy patient monitoring, especially when electroretinography cannot be performed.
authors.forename: M V
authors.initials: MV
authors.lastname: Zueva
authors.forename: I V
authors.initials: IV
authors.lastname: Tsapenko
authors.forename: S V
authors.initials: SV
authors.lastname: Saakian
authors.forename: O G
authors.initials: OG
authors.lastname: Panteleeva
authors.forename: A A
authors.initials: AA
authors.lastname: Zharua
authors.forename: L S
authors.initials: LS
authors.lastname: Orlovskaia
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D057186:Comparative Effectiveness Research; D016903:Drug Monitoring / Q000379:methods*; D019008:Drug Resistance, Neoplasm; D004596:Electroretinography / Q000379:methods; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial; D008297:Male; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D010775:Photic Stimulation / Q000379:methods; D012160:Retina / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents