title: The generation of sex cells.
abstract: Primordial germ cells (PGCs) are the earliest population of germ cells established during embryonic development and constitute the beginning of the totipotent state. A recent study provides a new protocol for the efficient generation of PGC-like cells from human embryonic stem cells, providing an in vitro platform to study human PGC differentiation and specification.
authors.affiliation: Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, USA.
authors.forename: Alessia
authors.initials: A
authors.lastname: Deglincerti
authors.affiliation: Laboratory of Stem Cell Biology and Molecular Embryology, The Rockefeller University, USA.
authors.forename: Ali H
authors.initials: AH
authors.lastname: Brivanlou
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D053595:Embryonic Stem Cells / Q000166:cytology*; D005260:Female; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D008297:Male; D009865:Oocytes / Q000166:cytology*; D006080:Ovarian Follicle / Q000166:cytology*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*