title: Hyperferritinemia is associated with short survival time in dogs with multicentric lymphoma.
abstract: In the present study, we examined the relationship between serum ferritin concentration before treatment and survival time in dogs with multicentric lymphoma. Eighteen dogs with multicentric lymphoma were enrolled in the study. When the dogs were classified into high and low ferritin groups on the basis of their serum ferritin concentration (3,000 ng/ml cut-off value), the median survival time of dogs with high concentrations (≥3,000 ng/ml, n=7) was 40 days, whereas it was 360 days among dogs with low concentrations (<3,000 ng/ml, n=11). This difference was statistically significant (P=0.001). This finding suggests that the initial high level of serum ferritin indicates short survival time in dogs with multicentric lymphoma. Large-scale research is necessary to confirm this finding.
authors.affiliation: Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University, 23-35-1 Higashi, Towada, Aomori 034-8628, Japan.
authors.forename: Seishiro
authors.initials: S
authors.lastname: Chikazawa
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Hori
authors.forename: Fumio
authors.initials: F
authors.lastname: Hoshi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kanai
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Ito
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000401:mortality*; D004285:Dogs; D005260:Female; D005293:Ferritins / Q000097:blood*; D008223:Lymphoma / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D008297:Male; D016019:Survival Analysis
chemical_list: D005293:Ferritins