title: Oral penicillin-associated acute kidney injury in an infant with acute pyelonephritis.
abstract: Beta-lactam-associated acute tubulointerstitial nephritis (ATIN) is a rare condition in childhood. We report the case of an infant with penicillin-associated ATIN and concomitant acute pyelonephritis resulting in the development of severe acute kidney injury (AKI). The treatment consisted of penicillin suspension and appropriate AKI management, which required a short period of dialysis. Finally, full recovery and normalization of laboratory parameters occurred. We present here the first case of oral penicillin-associated ATIN in childhood.
authors.affiliation: Department of Paediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Praha, Czech Republic.
authors.forename: Jakub
authors.initials: J
authors.lastname: Zieg
authors.forename: Jaromir
authors.initials: J
authors.lastname: Hacek
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D010406:Penicillins / Q000008:administration & dosage / Q000009:adverse effects*; D010530:Peritoneal Dialysis; D011704:Pyelonephritis / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins
keywords: acute kidney injury; acute tubulointerstitial nephritis; penicillin