title: [Polyacrylates of noble metals as potential antitumor drugs].
abstract: The antitumor activity of polyacrylates of the noble metals containing argentum (argacryl), aurum (auracryl) and platinum (platacryl) has been studied using experimental murine solid tumor models (Lewis lung carcinoma and Acatol adenocarcinoma). It has been found that polyacrylates of the noble metals are capable of inhibiting tumor development by 50-90% compared to control. Auracryl that inhibites the growth of Lewis lung carcinoma and Acatol adenocarcinoma by 80 and 90%, respectively, compared to control is the most efficient among the tested compounds and can be recommended for the further profound preclinical studies.
authors.forename: L A
authors.initials: LA
authors.lastname: Ostrovskaia
authors.forename: M G
authors.initials: MG
authors.lastname: Voronkov
authors.forename: D B
authors.initials: DB
authors.lastname: Korman
authors.forename: N V
authors.initials: NV
authors.lastname: Bliukhterova
authors.forename: M M
authors.initials: MM
authors.lastname: Fomina
authors.forename: V A
authors.initials: VA
authors.lastname: Rykova
authors.forename: K A
authors.initials: KA
authors.lastname: Abzaeva
authors.forename: L V
authors.initials: LV
authors.lastname: Zhilitskaia
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology*; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010984:Platinum / Q000737:chemistry / Q000494:pharmacology*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D012834:Silver; D010984:Platinum; C006903:carbopol 940; D006046:Gold