title: Exposure Reconstruction and Risk Analysis for Six Semiconductor Workers With Lymphohematopoietic Cancers.
abstract: OBJECTIVE
  To investigate whether workplace exposures to recognized lymphohematopoietic carcinogens were possibly related to cancers in six semiconductor-manufacturing workers.
  
  
  METHODS
  A job-exposure matrix was developed for chemical and physical process agents and anticipated by-products. Potential cumulative occupational exposures of the six cases were reconstructed. The role of workplace exposures in cancer was evaluated through quantitative risk assessment and by comparison with epidemiological literature.
  
  
  RESULTS
  Two workers were potentially exposed to agents capable of causing their diagnosed cancers. Reconstructed exposures were similar to levels in outdoor environments and lower than exposures associated with increased risks in epidemiological studies. Cancer risks were estimated to be less than 1 in 10,000 persons.
  
  
  CONCLUSIONS
  The development of cancer among the six workers was unlikely to be explained by occupational exposures to recognized lymphohematopoietic carcinogens.
authors.affiliation: From ENVIRON International Corporation (Dr Jones, Ms Simmons, and Ms Boelter) and School of Public Health, University of Illinois at Chicago (Dr Jones); ENVIRON International Corporation (Ms Dell), Amherst, MA; ENVIRON International Corporation (Mr Torres), Atlanta, GA; ENVIRON International Corporation (Dr Poole), Tampa, FL; and ENVIRON International Corporation (Mr Harper), Phoenix, AZ. Ms Simmons is currently employed by Simmons Environmental and Occupational Health Solutions. Mr Torres is currently employed by Gates Rubber.
authors.forename: Rachael M
authors.initials: RM
authors.lastname: Jones
authors.forename: Linda
authors.initials: L
authors.lastname: Dell
authors.forename: Craig
authors.initials: C
authors.lastname: Torres
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Simmons
authors.forename: James
authors.initials: J
authors.lastname: Poole
authors.forename: Fred W
authors.initials: FW
authors.lastname: Boelter
authors.forename: Paul
authors.initials: P
authors.lastname: Harper
mesh_terms: D000328:Adult; D002273:Carcinogens; D019337:Hematologic Neoplasms / Q000453:epidemiology*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology*; D016273:Occupational Exposure; D018570:Risk Assessment; D012666:Semiconductors
chemical_list: D002273:Carcinogens