title: Cu(II)-catalyzed coupling of aromatic C-H bonds with malonates.
abstract: A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp(2))-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Shang
authors.forename: Shang-Zheng
authors.initials: SZ
authors.lastname: Sun
authors.forename: Zeng-Le
authors.initials: ZL
authors.lastname: Zhou
authors.forename: Brian N
authors.initials: BN
authors.lastname: Laforteza
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Dai
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006860:Hydrogen Bonding; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D058451:Oxidative Coupling
chemical_list: D008314:Malonates; D010080:Oxazoles; D003300:Copper; C030290:malonic acid