title: Molecular targets of luteolin in cancer.
abstract: Many food-derived phytochemical compounds and their derivatives represent a cornucopia of new anticancer compounds. Despite extensive study of luteolin, the literature has no information on the exact mechanisms or molecular targets through which it deters cancer progression. This review discusses existing data on luteolin's anticancer activities and then offers possible explanations for and molecular targets of its cancer-preventive action. Luteolin prevents tumor development largely by inactivating several signals and transcription pathways essential for cancer cells. This review also offers insights into the molecular mechanisms and targets through which luteolin either prevents cancer or mediates cancer cell death.
authors.affiliation: Zoology Department, Division of Physiology, Faculty of Science, Damanhour University, Damanhour, Egypt.
authors.forename: Muobarak J
authors.initials: MJ
authors.lastname: Tuorkey
mesh_terms: D000818:Animals; D006801:Humans; D047311:Luteolin / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D047311:Luteolin