title: Hearing preservation using topical dexamethasone alone and associated with hyaluronic acid in cochlear implantation.
abstract: CONCLUSIONS
  Topical dexamethasone associated with hyaluronic acid in cochlear implant surgery demonstrated a statistically significant difference in the preservation of low-frequency thresholds when compared with topical dexamethasone alone and a control group. Topical dexamethasone alone was not superior in hearing preservation when compared to the control group.
  
  
  OBJECTIVE
  To compare the effects of topical dexamethasone alone and associated with hyaluronic acid intraoperatively in hearing preservation in cochlear implantation.
  
  
  METHODS
  Eighteen severely to profoundly hearing-impaired adult patients with measurable hearing were divided into three groups preoperatively: cochlear implantation as a control group (group 1), cochlear implantation using topical dexamethasone intraoperatively (group 2), and cochlear implantation using topical dexamethasone associated with hyaluronic acid intraoperatively (group 3). Preimplant and postimplant low-frequency pure-tone averages (PTAs) were calculated from unaided audiograms at 125, 250, and 500 Hz.
  
  
  RESULTS
  The mean changes in the low-frequency PTA comparing postoperative against preoperative thresholds were 28.03 ± 6.77 dB in group 1, 30 ± 14.53 dB in group 2, and 7.23 ± 6.12 dB in group 3. There was statistical difference when comparing group 3 with groups 1 and 2 using one-way ANOVA (p = 0.002) followed by Scheffé post hoc test.
authors.affiliation: Department of Otolaryngology, University of São Paulo School of Medicine , São Paulo , Brazil.
authors.forename: Bernardo Faria
authors.initials: BF
authors.lastname: Ramos
authors.forename: Robinson Koji
authors.initials: RK
authors.lastname: Tsuji
authors.forename: Ricardo Ferreira
authors.initials: RF
authors.lastname: Bento
authors.forename: Maria Valeria Schmidt
authors.initials: MV
authors.lastname: Goffi-Gomez
authors.forename: Henrique Faria
authors.initials: HF
authors.lastname: Ramos
authors.forename: Paola Angelica
authors.initials: PA
authors.lastname: Samuel
authors.forename: Rubens
authors.initials: R
authors.lastname: Brito
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects*; D019929:Cochlear Implantation / Q000379:methods*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003907:Dexamethasone; D006820:Hyaluronic Acid
keywords: Hearing loss; cochlear implant; pharmacotherapy