title: Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis.
abstract: OBJECTIVE
  To evaluate the correlation between Acute Physiology and Chronic Health Evaluation II (APACHE II) score and plasma concentrations of copeptin, C-reactive protein (CRP) and procalcitonin in patients with sepsis.
  
  
  METHODS
  Patients with sepsis were prospectively enrolled. APACHE II scores were determined during the first 24 h after admission to the intensive care unit. Plasma copeptin, CRP and procalcitonin were quantified at admission, 24 h, 48 h, and 72 h. Survival at 28 days after admission was recorded.
  
  
  RESULTS
  APACHE II score was significantly positively correlated with plasma copeptin, CRP and procalcitonin concentrations. Survivors (n = 15) had significantly lower APACHE II scores and copeptin, CRP and procalcitonin concentrations than nonsurvivors (n = 26). APACHE II score, copeptin at 72 h, CRP at 48 h and procalcitonin at 24 h were independent risk factors for death.
  
  
  CONCLUSIONS
  Plasma copeptin, CRP and procalcitonin concentrations were positively correlated with APACHE II score in patients with sepsis, and reflected disease severity.
authors.affiliation: Emergency Department, The first affiliated Hospital of DaLian Medical University, DaLian, China fangrong928@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Emergency Department, The first affiliated Hospital of DaLian Medical University, DaLian, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.affiliation: Emergency Department, The first affiliated Hospital of DaLian Medical University, DaLian, China.
authors.forename: Dongna
authors.initials: D
authors.lastname: Gao
authors.affiliation: Emergency Department, The first affiliated Hospital of DaLian Medical University, DaLian, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D018805:Sepsis / Q000097:blood* / Q000401:mortality / Q000473:pathology; D012720:Severity of Illness Index; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D006020:Glycopeptides; D011498:Protein Precursors; C048197:copeptins; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: APACHE II; C-reactive protein; Sepsis; copeptin; procalcitonin