title: Origin, evolution and innate immune control of simian foamy viruses in humans.
abstract: Most viral pathogens that have emerged in humans have originated from various animal species. Emergence is a multistep process involving an initial spill-over of the infectious agent into single individuals and its subsequent dissemination into the human population. Similar to simian immunodeficiency viruses and simian T lymphotropic viruses, simian foamy viruses (SFV) are retroviruses that are widespread among non-human primates and can be transmitted to humans, giving rise to a persistent infection, which seems to be controlled in the case of SFV. In this review, we present current data on the discovery, cross-species transmission, and molecular evolution of SFV in human populations initially infected and thus at risk for zoonotic emergence.
authors.affiliation: Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, 28 Rue du Dr. Roux, 75015 Paris, France; Département de Virologie, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris, Cedex 15, France; CNRS, UMR369, 28 Rue du Dr. Roux, F-75015 Paris, France; Université Paris Diderot, Cellule Pasteur, Paris, France. Electronic address: rejane.rua@nih.gov.
authors.forename: Rejane
authors.initials: R
authors.lastname: Rua
authors.affiliation: Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, 28 Rue du Dr. Roux, 75015 Paris, France; Département de Virologie, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris, Cedex 15, France; CNRS, UMR369, 28 Rue du Dr. Roux, F-75015 Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Gessain
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000235:genetics; D019143:Evolution, Molecular; D016679:Genome, Viral; D006801:Humans; D018419:Primate Diseases / Q000821:virology; D011323:Primates; D012192:Retroviridae Infections / Q000276:immunology* / Q000635:transmission* / Q000662:veterinary / Q000821:virology; D053150:Simian foamy virus / Q000235:genetics* / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology / Q000648:ultrastructure; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism; D056189:Viral Tropism; D015047:Zoonoses
chemical_list: D004279:DNA, Viral; D015678:Viral Structural Proteins