title: Inflammasomes in pancreatic physiology and disease.
abstract: In this review we summarize the role of inflammasomes in pancreatic physiology and disease with a focus on acute pancreatitis where much recent progress has been made. New findings have identified inducers of and cell specificity of inflammasome component expression in the pancreas, the contribution of inflammasome-regulated effectors to pancreatitis, and metabolic regulation of inflammasome activation, which are strong determinants of injury in pancreatitis. New areas of pancreatic biology will be highlighted in the context of our evolving understanding of gut microbiome- and injury-induced inflammasome priming, pyroptosis, and innate immune-mediated regulation of cell metabolism.
authors.affiliation: Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut; and.
authors.forename: Rafaz
authors.initials: R
authors.lastname: Hoque
authors.affiliation: Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut; and Section of Digestive Diseases, Department of Veterans Affairs Connecticut Healthcare, West Haven, Connecticut wajahat.mehal@yale.edu.
authors.forename: Wajahat Z
authors.initials: WZ
authors.lastname: Mehal
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D010179:Pancreas / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D010182:Pancreatic Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: D058847:Inflammasomes; D018836:Inflammation Mediators
keywords: G protein-coupled receptor 109a; G protein-coupled receptor 81; NACHT, LRR, and PYD domains-containing protein 3; mitochondrial oxidation