title: Efficacy and Safety of Intravenous Thrombolysis for the Treatment of Acute Ischemic Stroke Patients with Saccular Intracranial Aneurysms of ≤3 mm.
abstract: To explore the effectiveness and safety of intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator in treating acute ischemic stroke patients with concomitant intracranial aneurysms (IA) of ≤3 mm. Clinical data of patients who were treated in Tianjin Huanhu Hospital from June 2012 to September 2013 were retrospectively analyzed. Patients were divided into the following groups: (a) IVT group, in which there were 30 acute ischemic stroke patients with IA of ≤3 mm and 30 patients without aneurysms; and (b) IA group, in which there were 30 patients who did not receive IVT and 30 patients who received IVT. The incidence of intracranial hemorrhage, case-fatality, and good outcome rate was compared within these two groups. Inside the IVT group, the incidence of systematic intracranial hemorrhage and case-fatality showed no significant differences between patients with concomitant IA and those without IA. The 3-month good outcome rate was also not significantly different (24 [80.0 %] vs. 27 [90 %]; P = 0.278). In IA group, patients who had received IVT showed significantly superior good outcome rate than those who had not received IVT (24 [80.0 %] vs. 16 [53.3 %]; P = 0.028).The incidence of intracranial hemorrhage and case-fatality rate were not significantly different between these two subgroups as well. IVT is effective and safe method for the treatment of acute ischemic stroke patients with saccular IA of ≤3 mm.
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Chen-Hao
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, China.
authors.forename: Chenhua
authors.initials: C
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Yu-Xin
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Yin
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Tong
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, 122 Qixiangtai Road, Hexi District, Tianjin, 300060, China. peilanzhng@126.com.
authors.forename: Pei-Lan
authors.initials: PL
authors.lastname: Zhang
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000188:drug therapy*; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects*
keywords: Acute ischemic stroke; Intracranial aneurysms; Intravenous thrombolysis; Recombinant tissue plasminogen activator