title: Nuclear pore proteins and the control of genome functions.
abstract: Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.
authors.affiliation: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Ibarra
authors.affiliation: Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA hetzer@salk.edu.
authors.forename: Martin W
authors.initials: MW
authors.lastname: Hetzer
mesh_terms: D000818:Animals; D058674:Chromosome Duplication / Q000235:genetics; D020090:Chromosome Segregation / Q000235:genetics; D005786:Gene Expression Regulation; D016678:Genome; D042822:Genomic Instability; D006801:Humans; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D028861:Nuclear Pore Complex Proteins
keywords: DNA damage; mitosis; nuclear envelope; nuclear genome; nuclear pore complex; nucleoporin; transcription control