title: Novel pH-sensitive hydrogels for 5-aminosalicylic acid colon targeting delivery: in vivo study with ulcerative colitis targeting therapy in mice.
abstract: Current guidelines recommend patients with active and mild-to-moderate ulcerative colitis (UC), who have received initial therapy with 5-aminosalicylic acid (5-ASA). In this study, a novel drug delivery vehicle achieved by pH-sensitive hydrogels was applied to 5-ASA. In our previous work, a novel P(CE-MAA-MEG) pH-sensitive hydrogel was successfully synthesized by the heat-initiated free radical polymerization method. The aim of this study is to investigate its site-specific delivering of drugs to the colon and evaluate its colon-targeting characteristic in vivo. 5-ASA was chosen as a model drug and successfully loaded in the hydrogel. In vitro investigations were carried out to evaluate its release process. Above all, animal treatment results reveal an obvious effect on the UC healing. Therefore, all results suggested that the developed 5-ASA-P(CE-MAA-MEG) hydrogel (5-ASA-GEL) as a colon-targeting vector might have a great potential application in the UC therapy.
authors.affiliation: a Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Xi'an Jiaotong University , Xi' an , China .
authors.forename: Xia Yan
authors.initials: XY
authors.lastname: Bai
authors.affiliation: b School of Pharmacy, Xi'an Jiaotong University , Xi' an , China , and.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: c The Central Hospital of Xi' an Huashan , Xi' an , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: b School of Pharmacy, Xi'an Jiaotong University , Xi' an , China , and.
authors.forename: Lan Gui
authors.initials: LG
authors.lastname: Zhao
authors.affiliation: b School of Pharmacy, Xi'an Jiaotong University , Xi' an , China , and.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003106:Colon / Q000187:drug effects*; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D019804:Mesalamine / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020100:Hydrogels; D019804:Mesalamine
keywords: Colon-targeting characteristic; site-specific delivering of drugs; ulcerative colitis