title: Building a roadmap for developing combination therapies for Alzheimer's disease.
abstract: Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases. A growing number of investigators in academia, industry, regulatory agencies, foundations and advocacy organizations are interested in pursuing a combination approach to treating Alzheimer's disease. A meeting co-hosted by the Accelerate Cure/Treatments for Alzheimer's Disease Coalition, the Critical Path Institute and the Alzheimer's Association addressed challenges in designing clinical trials to test multiple treatments in combination and outlined a roadmap for making such trials a reality.
authors.affiliation: Alliance for Aging Research, Washington, DC, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Perry
authors.forename: Reisa
authors.initials: R
authors.lastname: Sperling
authors.forename: Russell
authors.initials: R
authors.lastname: Katz
authors.forename: Donald
authors.initials: D
authors.lastname: Berry
authors.forename: David
authors.initials: D
authors.lastname: Dilts
authors.forename: Debra
authors.initials: D
authors.lastname: Hanna
authors.forename: Stephen
authors.initials: S
authors.lastname: Salloway
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Chas
authors.initials: C
authors.lastname: Bountra
authors.forename: Michael
authors.initials: M
authors.lastname: Krams
authors.forename: Johan
authors.initials: J
authors.lastname: Luthman
authors.forename: Steven
authors.initials: S
authors.lastname: Potkin
authors.forename: Val
authors.initials: V
authors.lastname: Gribkoff
authors.forename: Robert
authors.initials: R
authors.lastname: Temple
authors.forename: Yaning
authors.initials: Y
authors.lastname: Wang
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
authors.forename: Diane
authors.initials: D
authors.lastname: Stephenson
authors.forename: Heather
authors.initials: H
authors.lastname: Snyder
authors.forename: Enchi
authors.initials: E
authors.lastname: Liu
authors.forename: Tony
authors.initials: T
authors.lastname: Ware
authors.forename: John
authors.initials: J
authors.lastname: McKew
authors.forename: F Owen
authors.initials: FO
authors.lastname: Fields
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Bain
authors.forename: Cynthia
authors.initials: C
authors.lastname: Bens
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006801:Humans; D033181:Information Dissemination; D008962:Models, Theoretical
keywords: Alzheimer’ disease; co-development; collaboration; combination therapy; novel therapy