title: Post-infectious bronchiolitis obliterans in children: CT features that predict responsiveness to pulse methylprednisolone.
abstract: OBJECTIVE
  Intravenous pulse methylprednisolone therapy (IPMT) is an important treatment option for post-infectious obliterative bronchiolitis (OB), although it must be used carefully and only in selected patients because of its drawbacks. This study evaluated whether CT and clinical features of children with post-infectious OB can predict their responsiveness to IPMT.
  
  
  METHODS
  We searched the medical records for patients (less than 18 years of age) who were diagnosed with post-infectious OB between January 2000 and December 2011. 17 children who received IPMT were included in this study. All underwent chest CT before and after IPMT. The radiological features seen on pre-treatment CT were recorded. The air-trapping area percentages on pre- and post-treatment CT images were determined. The nine patients who exhibited decreased air trapping on post-treatment CT scans relative to pre-treatment scans were classed as responders. The patient ages and time from initial pneumonia to IPMT were recorded.
  
  
  RESULTS
  All responders and only four non-responders had thickened bronchial walls before treatment (p = 0.029). The two groups did not differ significantly in terms of bronchiolitis, bronchiectasis or the extent of air trapping, although the responders had a significantly shorter median interval between initial pneumonia and IPMT (4 vs 50 months; p = 0.005) and were significantly younger (median, 2.0 vs 7.5 years; p = 0.048).
  
  
  CONCLUSIONS
  Immediate IPMT may improve the degree of air trapping in children with post-infectious OB if they show a thickened bronchial wall on CT.
  
  
  CONCLUSIONS
  Children with post-infectious OB may respond favourably to IPMT when pre-treatment CT indicates bronchial-wall thickening.
authors.affiliation: 1 Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
authors.forename: H M
authors.initials: HM
authors.lastname: Yoon
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: J-Y
authors.initials: JY
authors.lastname: Hwang
authors.forename: Y A
authors.initials: YA
authors.lastname: Cho
authors.forename: H-K
authors.initials: HK
authors.lastname: Yoon
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: S-J
authors.initials: SJ
authors.lastname: Hong
authors.forename: C H
authors.initials: CH
authors.lastname: Yoon
mesh_terms: D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone