title: Relationship between epicardial adipose tissue thickness and early impairment of left ventricular systolic function in patients with preserved ejection fraction.
abstract: Epicardial adipose tissue (EAT) is metabolically bioactive fat. The present study aimed to clarify the relationship between EAT amount and early impairment of left ventricular (LV) systolic function in patients with preserved ejection fraction (EF), all evaluated echocardiographically. Participants comprised 62 elderly women (mean age ± standard deviation, 68 ± 11 years) with lifestyle-related diseases and EF ≥ 60 %. EAT amount was evaluated as thickness. Parameters suggesting early impairment of systolic function such as decreases in systolic mitral annular velocity (S') and tissue mitral annular displacement percentage (TMAD %) were evaluated along with EF. Correlations between EAT thickness and these LV systolic functions were assessed. Influences of various factors on the resultant significant relationships were also assessed. EAT thickness correlated inversely with S' and TMAD % (r = -0.402, p = 0.001 and r = -0.585, p < 0.001, respectively), but did not correlate with EF (r = 0.054, not significant). These significant relationships were maintained after considering factors such as body mass index, age, presence of lifestyle-related diseases and blood test results. A significant relationship existed between EAT amount and early impairment of LV systolic function in patients with preserved EF. Accumulation of EAT might contribute to the initial development of LV systolic dysfunction.
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Watanabe
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan. kishino@ks.kyorin-u.ac.jp.|Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. kishino@ks.kyorin-u.ac.jp.|Department of Clinical Engineering, Kyorin University Faculty of Health Sciences, Tokyo, Japan. kishino@ks.kyorin-u.ac.jp.|The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. kishino@ks.kyorin-u.ac.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kishino
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Sano
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ariga
authors.affiliation: The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Shuhei
authors.initials: S
authors.lastname: Okuyama
authors.affiliation: The Third Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Mori
authors.affiliation: Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Matsushima
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.|Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Ohtsuka
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.|Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohnishi
authors.affiliation: Department of Clinical Laboratory, Kyorin University Hospital, Tokyo, Japan.|Department of Laboratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000503:physiopathology; D050154:Adiposity; D000368:Aged; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011237:Predictive Value of Tests; D013318:Stroke Volume; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016277:Ventricular Function, Left
keywords: Echocardiography; Epicardial adipose tissue; Impairment; Left ventricular systolic function; Lifestyle-related disease; S′; TMAD %; Women