title: Effects of immunomodulators on functional activity of innate immunity cells infected with Streptococcus pneumoniae.
abstract: Low activity of bactericidal enzymes was found in innate immunity cells infected with S. pneumonia. The death of these cells was fastened under these conditions. On the contrary, treatment with antibiotic maxifloxacin was followed by an increase in activity of bactericidal enzymes in phagocytes and induced their death via necrosis. Analysis of the therapeutic properties of immunomodulators tinrostim and licopid in combination with maxifloxacin showed that these combinations correct functional activity of cells infected with S. pneumonia.
authors.affiliation: G. P. Somov Research Institute of Epidemiology and Microbiology, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia, pl_pat@hotmail.com.
authors.forename: N G
authors.initials: NG
authors.lastname: Plekhova
authors.forename: N M
authors.initials: NM
authors.lastname: Kondrashova
authors.forename: L M
authors.initials: LM
authors.lastname: Somova
authors.forename: E I
authors.initials: EI
authors.lastname: Drobot
authors.forename: I N
authors.initials: IN
authors.lastname: Lyapun
mesh_terms: D000818:Animals; D006690:Bisbenzimidazole; D024841:Fluoroquinolones / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology*; D056747:Immunomodulation / Q000187:drug effects*; D008297:Male; D051379:Mice; D000077266:Moxifloxacin; D010586:Phagocytes / Q000187:drug effects; D011008:Pneumococcal Infections / Q000188:drug therapy*; D013296:Streptococcus pneumoniae
chemical_list: D024841:Fluoroquinolones; D007155:Immunologic Factors; D006690:Bisbenzimidazole; D000077266:Moxifloxacin