title: Likelihood free inference for Markov processes: a comparison.
abstract: Approaches to Bayesian inference for problems with intractable likelihoods have become increasingly important in recent years. Approximate Bayesian computation (ABC) and "likelihood free" Markov chain Monte Carlo techniques are popular methods for tackling inference in these scenarios but such techniques are computationally expensive. In this paper we compare the two approaches to inference, with a particular focus on parameter inference for stochastic kinetic models, widely used in systems biology. Discrete time transition kernels for models of this type are intractable for all but the most trivial systems yet forward simulation is usually straightforward. We discuss the relative merits and drawbacks of each approach whilst considering the computational cost implications and efficiency of these techniques. In order to explore the properties of each approach we examine a range of observation regimes using two example models. We use a Lotka-Volterra predator-prey model to explore the impact of full or partial species observations using various time course observations under the assumption of known and unknown measurement error. Further investigation into the impact of observation error is then made using a Schlögl system, a test case which exhibits bi-modal state stability in some regions of parameter space.
authors.forename: Jamie
authors.initials: J
authors.lastname: Owen
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Wilkinson
authors.forename: Colin S
authors.initials: CS
authors.lastname: Gillespie
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D003198:Computer Simulation; D007700:Kinetics; D016013:Likelihood Functions; D008390:Markov Chains; D008954:Models, Biological; D009010:Monte Carlo Method; D049490:Systems Biology