title: An acute bout of exercise modulate the inflammatory response in peripheral blood mononuclear cells in healthy young men.
abstract: BACKGROUND
  Exercise increases the levels of circulating inflammatory mediators.
  
  
  OBJECTIVE
  Does an acute bout of exercise affect the mRNA gene expression level of inflammatory markers in peripheral blood mononuclear cells (PBMCs) and contribute to the circulating levels of inflammatory mediators?
  
  
  METHODS
  Ten healthy, non-smoking men (22-28 years old) performed 1-hour cycling at 70% of VO2 max.
  
  
  RESULTS
  The gene transcripts of CXCL16, IL-1β, IL-8, COX-2, TXB21 and GATA3 were significantly up-regulated in PBMCs. Serum levels of CXCL16, IL-6, TNFα and IL-10 were also significantly increased after exercise.
  
  
  CONCLUSIONS
  Increased mRNA transcription of inflammatory genes in PBMCs may contribute to increased level of inflammatory markers after an acute bout of exercise. The increased mRNA levels of GATA-3 and TXB21 may indicate that T cell lymphocytes are activated and secrete cytokines into the circulation. It needs to be further investigated if exercise changes the Th1/Th2 balance.
authors.affiliation: Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences , St Olavsplass, Oslo , Norway .
authors.forename: Stine M
authors.initials: SM
authors.lastname: Ulven
authors.forename: Silje Stange
authors.initials: SS
authors.lastname: Foss
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Skjølsvik
authors.forename: Hans Kristian
authors.initials: HK
authors.lastname: Stadheim
authors.forename: Mari Cw
authors.initials: MC
authors.lastname: Myhrstad
authors.forename: Ellen
authors.initials: E
authors.lastname: Raael
authors.forename: Marit
authors.initials: M
authors.lastname: Sandvik
authors.forename: Ingunn
authors.initials: I
authors.lastname: Narverud
authors.forename: Lene Frost
authors.initials: LF
authors.lastname: Andersen
authors.forename: Jørgen
authors.initials: J
authors.lastname: Jensen
authors.forename: Kirsten B
authors.initials: KB
authors.lastname: Holven
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002478:Cells, Cultured; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Acute exercise; T helper cell response; gene expression; inflammation; peripheral blood mononuclear cells