title: Role of PI3K, MAPK/ERK1/2, and p38 in implementation of the proliferative and differentiation potential of erythroid progenitors after blood loss.
abstract: The involvement of PI3K, ERK and p38-dependent signaling system in the regulation of functional activity of erythroid precursors after blood loss (30% of circulating volume) was studied. We demonstrated the important role of PI3K and p38 in the suppression of differentiation of erythroid precursors the contribution of p38 to stimulation of mitotic activity of erythroid CFU, which maintains the growth potential of the precursors at the optimal physiological level. The classical MAPK/ERK-kinase pathway does not determine the proliferative and differentiation status of erythroid CFU.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, laarmi@yandex.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: E Yu
authors.initials: EY
authors.lastname: Sherstoboev
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Burmina
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: D V
authors.initials: DV
authors.lastname: Reichart
authors.forename: V E
authors.initials: VE
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology*; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000502:physiology*; D006470:Hemorrhage / Q000503:physiopathology*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D019869:Phosphatidylinositol 3-Kinases