title: Association between TLR4 A299G polymorphism and pneumonia risk: a meta-analysis.
abstract: BACKGROUND
  Several genetic studies have evaluated the association between Toll-like receptor 4 (TLR4) A299G polymorphism and the risk of pneumonia. However, the results were not consistent. We thus did this meta-analysis.
  
  
  METHODS
  Relevant studies were systematically searched by using the NCBI, Medline, Web of Science, and Embase databases. Data were extracted independently by 2 investigators. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated.
  
  
  RESULTS
  Eight case-control studies with 658 patients and 1862 controls were included in this meta-analysis. TLR4 A299G polymorphism was significantly associated with pneumonia risk (OR=1.74; 95% CI 1.19-2.53; P=0.004). The result was significant in adults. In addition, TLR4 A299G polymorphism was also associated with community-acquired pneumonia (CAP) risk. Results from cumulative meta-analysis and sensitivity analysis suggested that the results are reliable and robust.
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that susceptibility to pneumonia was associated with TLR4 A299G polymorphism.
authors.affiliation: Department of Respiratory, Hainan Provincial People's Hospital, Haikou, Hainan, China (mainland).
authors.forename: Xingjun
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Respiratory, Hainan Provincial People's Hospital, Haikou, Hainan, China (mainland).
authors.forename: Yihui
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Department of Respiratory, Hainan Provincial People's Hospital, Haikou, Hainan, China (mainland).
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D002675:Child, Preschool; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D051197:Toll-Like Receptor 4 / Q000235:genetics*
chemical_list: C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4