title: Mouse models of glioma.
abstract: Gliomas are the most common primary tumour in the central nervous system in adults. The pathological hallmark of gliomas is their propensity for extensive infiltration into the surrounding brain parenchyma which results in tumour recurrence. Despite the use of optimal surgical removal and adjuvant therapies the most aggressive of these tumours, glioblastoma multiforme, has a poor patient prognosis, with median survival of less than 15 months. In this review, we discuss mouse glioma models that have been utilised to advance our basic knowledge of the processes involved in gliomagenesis and their use in the testing of novel therapies and treatment regimens in the preclinical setting.
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia. Electronic address: stanley.stylli@mh.org.au.
authors.forename: Stanley S
authors.initials: SS
authors.lastname: Stylli
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Rodney B
authors.initials: RB
authors.lastname: Luwor
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Thomas M B
authors.initials: TM
authors.lastname: Ware
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia.
authors.forename: Fiona
authors.initials: F
authors.lastname: Tan
authors.affiliation: Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3052, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy; D004195:Disease Models, Animal; D005910:Glioma / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy; D051379:Mice
keywords: Brain tumour; Glioma; Mouse model; Therapy