title: Alginate beads of Captopril using galactomannan containing Senna tora gum, guar gum and locust bean gum.
abstract: Gastro-retentive Captopril loaded alginate beads were prepared by an ionotropic gelation method using sodium alginate in combination with natural gums containing galactomannans (Senna tora seed gum, guar gum and locust bean gum) in the presence of calcium chloride. The process variables such as concentration of sodium alginate/natural polymer, concentration of calcium chloride, curing time, stirring speed and drying condition were optimized. Prepared beads were evaluated for various parameters such as flow property, drug content and entrapment efficiency, size and shape, and swelling index. Surface morphology of the beads was studied using scanning electron microscopy. In vitro mucoadhesion and in vitro drug release studies were carried out on the prepared beads. From the entrapment efficiency and dissolution study, it was concluded that galactomannans in combination with sodium alginate show sustained release property. The bead formulation F4 prepared using combination of sodium alginate and guar gums in the ratio 2:1 showed satisfactory sustained release for 12h. The release of Captopril from the prepared beads was found to be controlled by the swelling of the polymer followed by drug diffusion through the swelled polymer and slow erosion of the beads.
authors.affiliation: Research Scholar, Ultra College of Pharmacy, 4/235 College Road, Thasildar Nagar, Madurai 625020, Tamil Nadu, India. Electronic address: hapkmk@rediffmail.com.
authors.forename: Harshal A
authors.initials: HA
authors.lastname: Pawar
authors.affiliation: Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, 4/235 College Road, Thasildar Nagar, Madurai 625020, Tamil Nadu, India. Electronic address: kg.lalitha@gmail.com.
authors.forename: K G
authors.initials: KG
authors.lastname: Lalitha
authors.affiliation: Department of Pharmaceutical Technology, Bharathidasan Institute of Technology, Anna University, Tiruchirapalli 620024, Tamil Nadu, India. Electronic address: rmani48@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Ruckmani
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002216:Captopril / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D005685:Galactans / Q000737:chemistry* / Q000302:isolation & purification; D005690:Galactose / Q000031:analogs & derivatives; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008351:Mannans / Q000737:chemistry* / Q000302:isolation & purification; D008863:Microspheres; D053149:Plant Gums / Q000737:chemistry* / Q000302:isolation & purification; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D004337:Drug Carriers; D005685:Galactans; D006603:Hexuronic Acids; D008351:Mannans; D053149:Plant Gums; C012990:galactomannan; D020723:Glucuronic Acid; D002216:Captopril; C007894:guar gum; C017471:locust bean gum; D005690:Galactose
keywords: Galactomannan; Guar gum; Locust bean gum