title: Genetics of Vascular Dementia.
abstract: Genetic studies are transforming the way we diagnose, evaluate and treat patients. The era of genome-wide association studies promised to discover common risk variants in heterogeneous disorders where previous small-scale association studies had on the whole failed. However, as we enter the post-association era a degree of disappoint is felt regarding the lack of risk factors with large effect for a number of disorders including vascular disease. Vascular disorders are sporadic by nature, though a familial component has been observed. This review will focus on vascular dementia, the genetic risk factors for vascular disorders and highlight how new technologies may overcome the limitations of genome-wide association and nominate those genes that influence disease risk.
authors.affiliation: Department of Neuroscience, Jacksonville, Florida, USA.
authors.forename: Melissa E
authors.initials: ME
authors.lastname: Murray
authors.affiliation: Department of Neurology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Meschia
authors.affiliation: Department of Neuroscience, Jacksonville, Florida, USA.
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.affiliation: Department of Neuroscience, Jacksonville, Florida, USA.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross