title: [Breast cancer in México: a 10-year trend analysis on incidence and age at diagnosis].
abstract: BACKGROUND
  Breast cancer is an important public health problem. Some countries have achieved a downward trend while in others, continues ascending. In México, information on incidence and age at diagnosis is isolated in time, and knowledge on trend analysis is lacking.
  
  
  OBJECTIVE
  To examine the 2003-2012 trend of the incidence rate and age at diagnosis of breast cancer in the northeast of México. We also analyze the trend of positivity to nodes, hormone receptors and HER2; and its association with age at diagnosis.
  
  
  METHODS
  This is an epidemiological study of breast cancer patients in a tertiary care hospital in Monterrey, México (n = 3,488). Only new cases with a histology report were included; if this was not available, the cytology result was considered. Trend analysis was performed using the JoinPoint regression program Version 3.5.
  
  
  RESULTS
  The breast cancer incidence rate increased from 26.7 to 49.8 per 100,000 between 2003 and 2011 (p < 0.05). The adjusted rate showed an annual percentage rate of change of +6.2% (95%CI 4.2, 8.2). The mean age was 55.7 ± 13.7 years and remained stable over time. Nodes, hormone receptors and HER2 positivity rate also remained stable over time. Age < 50 years increased twice the risk for positivity to nodes (OR 2.0, 95%CI 1.4, 2.7), ER-PR- (OR 1.8, 95% CI 1.4, 2.4) and ER-PR-HER2- (OR 1.9, 95%CI 1.5, 2.5).
  
  
  CONCLUSIONS
  The 10-year analysis showed a significant upward trend. This study represents a first effort in our country, for determining patterns on incidence and age at diagnosis of breast cancer, as well as that of biomarkers.
authors.affiliation: Unidad de Investigación Epidemiológica y en Servicios de Salud, IMSS.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Salinas-Martínez
authors.forename: Abigail
authors.initials: A
authors.lastname: Juárez-Ruiz
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Mathiew-Quirós
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Guzmán-De la Garza
authors.forename: Adriana
authors.initials: A
authors.lastname: Santos-Lartigue
authors.forename: César
authors.initials: C
authors.lastname: Escobar-Moreno
mesh_terms: D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases