title: [Aberrant expression of sox2 gene in malignant gliomas].
abstract: Both genetic and epigenetic changes underlite the mechanisms of tumor initiation and progression. In the present study we analyze sox2 gene expression and its epigenetic regulation in primary cultures of malignant gliomas. The sox2 expression was detected in the vast majority (74%) of the investigated gliomas and absent in morphologically normal brain tissue. This indicates the process of glioma malignant transformation. We have also shown that the association of different areas of the sox2 gene with important epigenetic markers, posttranslational modifications of H3 histone H3K4ac and H3K9met3, does not correlate with the sox2 expression. However, this may indicate the stochastic nature of the regulation of sox2 gene expression in malignant gliomas.
authors.forename: A V
authors.initials: AV
authors.lastname: Volnitskiĭ
authors.forename: E V
authors.initials: EV
authors.lastname: Semenova
authors.forename: T A
authors.initials: TA
authors.lastname: Shtam
authors.forename: R A
authors.initials: RA
authors.lastname: Kovalev
authors.forename: M V
authors.initials: MV
authors.lastname: Filatov
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D061251:Primary Cell Culture; D011499:Protein Processing, Post-Translational; D055748:SOXB1 Transcription Factors / Q000235:genetics* / Q000378:metabolism; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D006657:Histones; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors