title: Butyrolactones derivatives from the fermentation products of a plant entophytic fungus Penicillium oxalicum.
abstract: Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3-6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1 and 2 were evaluated. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%).
authors.affiliation: a Chemical Science and Technology Department, Kunming University , Kunming , 650214 , P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Huang
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.forename: Yuede
authors.initials: Y
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Dong
authors.forename: Gang
authors.initials: G
authors.lastname: Du
authors.forename: Xuemei
authors.initials: X
authors.lastname: Gao
authors.forename: Yinhai
authors.initials: Y
authors.lastname: Ma
authors.forename: Qiufen
authors.initials: Q
authors.lastname: Hu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification; D005285:Fermentation; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D007783:Lactones; C000603294:terrelactone A; C000603295:terrelactone B; D015107:4-Butyrolactone
keywords: Penicillium oxalicum 0403; anti-TMV activities; butyrolactone derivatives