title: Deep venous thrombosis was not detected after total knee arthroplasty in Japanese patients with haemophilia.
abstract: Combined thrombo-prophylaxis with mechanical and pharmacological methods is recommended in patients undergoing total knee or hip arthroplasty. As patients with 'untreated inherited bleeding disorders such as haemophilia' are at risk of bleeding, no prophylaxis has been prescribed for these patients. However, a retrospective study reported subclinical deep venous thrombosis (DVT) in 10% of patients with haemophilia undergoing major orthopaedic surgery. In this study, we aimed to evaluate the risk of DVT after total knee arthroplasty (TKA). We examined 38 TKA in 33 Japanese patients with haemophilia using ultrasonography. We did not detect DVT. The risk of DVT in patients with haemophilia after TKA may be lower than that in the general population. However, as patients with haemophilia progress in age, venous thromboembolism should be considered as a potential problem.
authors.affiliation: Department of Joint Surgery, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takedani
authors.affiliation: Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohnuma
authors.affiliation: Department of Joint Surgery, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Hirose
mesh_terms: D000328:Adult; D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D044466:Asian People; D005169:Factor VIII / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D013997:Time Factors; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D005169:Factor VIII
keywords: deep venous thrombosis; haemophilia; total knee arthroplasty; ultrasonography