title: Prenatal sonographic diagnosis of premature constriction of the fetal ductus arteriosus after maternal self-medication with benzydamine hydrochloride: report of 3 cases and review of the literature.
abstract: We report 3 cases of prenatal diagnosis of premature constriction of the ductus arteriosus after maternal benzydamine hydrochloride therapy (3-mg lozenges) in third-trimester pregnancies. In each case, fetal echocardiography revealed a dilated, hypocontractile right ventricle with severe tricuspid regurgitation and constriction of the ductus arteriosus. Although the effect of indomethacin and other nonsteroidal anti-inflammatory drugs on prenatal ductal constriction is well known, readily available over-the-counter nonsteroidal anti-inflammatory drugs such as benzydamine can have an equally deleterious effect and are best avoided in the third trimester of pregnancy.
authors.affiliation: Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Krzeszowski
authors.affiliation: Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Wilczyński
authors.affiliation: Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Grzesiak
authors.affiliation: Third Chair of Gynecology and Obstetrics, Department of Fetal-Maternal Medicine and Gynecology, Medical University, Lodz, Poland. dnowakowska@yahoo.com.
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowakowska
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001591:Benzydamine / Q000009:adverse effects*; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000000981:diagnostic imaging; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging* / Q000187:drug effects*; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000196:embryology; D006801:Humans; D011247:Pregnancy; D012651:Self Medication / Q000009:adverse effects; D016216:Ultrasonography, Prenatal / Q000379:methods*
chemical_list: D000893:Anti-Inflammatory Agents; D001591:Benzydamine
keywords: benzydamine hydrochloride; ductus arteriosus constriction; fetal echocardiography; obstetric ultrasound; prenatal diagnosis