title: Meta-analysis of drug-eluting balloon angioplasty and drug-eluting stent placement for infrainguinal peripheral arterial disease.
abstract: OBJECTIVE
  To perform a meta-analysis of randomized controlled trials (RCTs) of drug-eluting balloon (DEB) angioplasty and drug-eluting stents (DESs) for infrainguinal peripheral arterial disease.
  
  
  METHODS
  Systematic searches were performed for all relevant RCTs.
  
  
  RESULTS
  Eight RCTs for DEB angioplasty and 12 RCTs for a DES in peripheral arterial disease were identified. Meta-analysis demonstrated statistically significant superiority of DEB over plain balloon angioplasty of femoral-popliteal disease for late lumen loss, restenosis, and target lesion revascularization, with no benefit in major amputation or mortality. Statistically significant superiority of DEB over percutaneous transluminal angioplasty (PTA) was demonstrated for infrapopliteal disease for restenosis and target lesion revascularization. Drug-eluting stents showed statistically significant superiority over bare metal stents (BMSs) of femoral-popliteal disease for late lumen loss and restenosis, with no benefit in mortality or amputation. Drug-eluting stents showed statistically significant superiority over BMSs of infrapopliteal disease restenosis and target lesion revascularization, with no benefit in amputation or mortality.
  
  
  CONCLUSIONS
  Drug-eluting balloon angioplasty and DESs demonstrated superior outcomes compared to PTA and BMS, with no difference in amputation or mortality.
authors.affiliation: Division of Vascular and Interventional Radiology, Department of Diagnostic Imaging, Royal Victoria Hospital, Barrie. Electronic address: mark.baerlocher@alumni.utoronto.ca.
authors.forename: Mark Otto
authors.initials: MO
authors.lastname: Baerlocher
authors.affiliation: Department of Diagnostic Imaging, McMaster University, Hamilton, Ontario.
authors.forename: Sean Alexander
authors.initials: SA
authors.lastname: Kennedy
authors.affiliation: Division of Vascular and Interventional Radiology, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Rajebi
authors.affiliation: Department of Biology, Mount Allison University, Sackville, New Brunswick.
authors.forename: Felix J
authors.initials: FJ
authors.lastname: Baerlocher
authors.affiliation: Division of Vascular and Interventional Radiology, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Misra
authors.affiliation: Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Radiology, Stratton Medical Center, Albany, New York.
authors.forename: Boris
authors.initials: B
authors.lastname: Nikolic
mesh_terms: D000368:Aged; D000800:Angioplasty, Balloon / Q000401:mortality* / Q000706:statistics & numerical data; D054855:Drug-Eluting Stents / Q000706:statistics & numerical data*; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000401:mortality* / Q000628:therapy*; D011150:Popliteal Artery / Q000601:surgery; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D015996:Survival Rate