title: The Yin and Yang aspects of IL-27 in induction of cancer-specific T-cell responses and immunotherapy.
abstract: Accumulating evidences from animal studies have indicated that both endogenous and exogenous IL-27, an IL-12 family of cytokine, can increase antitumor T-cell activities and inhibit tumor growth. IL-27 can modulate Treg responses, and program effector T cells into a unique T-effector stem cell (TSEC) phenotype, which enhances T-cell survival in the tumor microenvironment. However, animal studies also suggest that IL-27 induces molecular pathways such as IL-10, PD-L1 and CD39, which may downregulate tumor-specific T-cell responses. In this review paper, we will discuss the Yin and Yang aspects of IL-27 in the induction of tumor-specific T-cell responses, and the potential impacts of these functions of IL-27 in the design of cancer immunotherapy.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Ming-Song
authors.initials: MS
authors.lastname: Li
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Liu
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Zhu
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Liu
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Bai
mesh_terms: D015703:Antigens, CD / Q000276:immunology; D001081:Apyrase / Q000276:immunology; D060890:B7-H1 Antigen / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016753:Interleukin-10 / Q000276:immunology; D007378:Interleukins / Q000276:immunology*; D054503:Lymphoid Progenitor Cells / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D059016:Tumor Microenvironment / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D060890:B7-H1 Antigen; C423236:CD274 protein, human; C508609:IL10 protein, human; D007378:Interleukins; C464565:MYDGF protein, human; D016753:Interleukin-10; D001081:Apyrase; C067869:CD39 antigen
keywords: IL-12; IL-27; T-effector stem cells; cancer immunotherapy; regulatory T cells