title: Antigen administration by continuous feeding enhances oral tolerance and leads to long-lasting effects.
abstract: The ability to avoid inflammatory responses to dietary components and microbiota antigens in the gut mucosa is achieved by a mechanism termed oral tolerance. This phenomenon is crucial to maintain the physiological immune activity in the gut and to prevent inflammatory disorders such as food allergy and inflammatory bowel diseases. Moreover, orally administered antigens induce regulatory cells that control systemic inflammatory responses as well. Given its specific, systemic and long-lasting effects, oral tolerance represents a promising approach for immunotherapies that aim to modulate inflammatory and autoimmune diseases. However, there are different protocols of feeding for induction of oral tolerance, and they have an impact in tolerance efficiency and length. Herein, we present and discuss different experimental feeding protocols and how they influence the outcome of oral administration of antigens.
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Rafael Pires
authors.initials: RP
authors.lastname: Oliveira
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Andrezza Fernanda
authors.initials: AF
authors.lastname: Santiago
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Sabine Madsen
authors.initials: SM
authors.lastname: Ficker
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Gomes-Santos
authors.affiliation: Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: afaria@icb.ufmg.br.
authors.forename: Ana Maria Caetano
authors.initials: AMC
authors.lastname: Faria
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003888:Desensitization, Immunologic / Q000379:methods*; D004750:Enteral Nutrition; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology / Q000517:prevention & control; D007108:Immune Tolerance / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D015212:Inflammatory Bowel Diseases / Q000276:immunology / Q000517:prevention & control; D007413:Intestinal Mucosa / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
chemical_list: D007073:Immunoglobulin E; D010047:Ovalbumin
keywords: Continuous feeding; Feeding protocols; Gavage; Gut mucosa; Oral tolerance