title: Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cells.
abstract: BACKGROUND
  Lippia nodiflora (LN) Linn is a small herb distributed throughout the world. The plant extracts of LN is used traditionally as an analgesic, anti-inflammatory, antioxidant, antibacterial, antimicrobial, antipyretic, antitumor, antidiabetic, and possess hepatoprotective properties.
  
  
  METHODS
  To study the antibacterial and hepatoprotective effect of LN, we used methanolic extracts of leaves on HepG2 cells. Lipopolysaccharides (LPS) is a well-characterized hepatotoxin, so toxicity was induced on liver cells using LPS. Up-regulation of inflammation genes were quantified.
  
  
  CONCLUSIONS
  In our present study, we have showed that LN reduced reactive oxygen species (ROS) production against LPS induced toxicity on HepG2 cells, and ther by decreased the apoptotic gene expression and protect the liver cells against toxicity.
authors.affiliation: Department of Pathology, Methodist Hospital Research Institute, Houston, Texas 77030, USA.
authors.forename: S
authors.initials: S
authors.lastname: Arumanayagam
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Arunmani
keywords: Apoptosis; HepG2 cells; Lippia nodiflora; methanloic extraction; reactive oxygen species