title: Obesity-related immune responses and their impact on surgical outcomes.
abstract: The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.
authors.affiliation: 1] Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany [3] Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Quante
authors.affiliation: 1] IFB Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany [2] Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Dietrich
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: ElKhal
authors.affiliation: Division of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Tullius
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D000075202:Contraindications; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D009765:Obesity / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D011183:Postoperative Complications / Q000276:immunology*; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators