title: A Population- and Hospital-based Cross-sectional Study of Renal Function in Hidradenitis Suppurativa.
abstract: The chronic inflammatory skin diseases hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular risk factors and the latter has also been linked to possible renal dysfunction. Since basement membrane thinning in the skin of HS patients has been described, we speculated whether similar basement membrane defects might occur in renal tissue. Our objective was to investigate a possible association between HS and renal dysfunction. We performed a hospital and population-based cross-sectional study using estimated Glomerular-Filtration-Rate (eGFR) to assess renal function. Thirty-two hospital individuals with HS, 430 population individuals with HS, and 20,780 population individuals without HS were (controls) identified. The age-, sex-, smoking-, BMI-, hypertension- and diabetes-adjusted analysis revealed a statistically significant higher eGFR for the hospital group with HS and a mean difference in eGFR of 6.81 (1.27-12.35) ml/min/1.73 m2 between the hospital group with HS and the population group without HS. The observed higher eGFR in the hospital group with HS indicates a possible association of HS and renal dysfunction.
authors.affiliation: Department of Dermatology, Roskilde Hospital; Faculty of Health and Medical Sciences, University of Copenhagen, DK-4000 Roskilde, Denmark. miller@dadlnet.dk.
authors.forename: Iben M
authors.initials: IM
authors.lastname: Miller
authors.forename: Nicholas
authors.initials: N
authors.lastname: Carlson
authors.forename: Ulla B
authors.initials: UB
authors.lastname: Mogensen
authors.forename: Christina
authors.initials: C
authors.lastname: Ellervik
authors.forename: Gregor B E
authors.initials: GB
authors.lastname: Jemec
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D017497:Hidradenitis Suppurativa / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010044:Outpatient Clinics, Hospital / Q000706:statistics & numerical data*; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D018881:Suburban Health / Q000706:statistics & numerical data*; D055815:Young Adult