title: Synthesis of deuterium-labelled isotopomer of deferasirox.
abstract: A d4 -labeled isotopomer of deferasirox was synthesized as internal standard for use in a LC/mass spectroscopy (MS)/MS method developed for the simultaneous quantitative determination of deferasirox in human serum. d4 -deferasirox was synthesized from d8 -toluene.
authors.affiliation: Nadkarni-Sacasa Research Laboratory, St. Xavier's College, Mumbai, India.
authors.forename: Freddy H
authors.initials: FH
authors.lastname: Havaldar
authors.forename: Bhushan Vasant
authors.initials: BV
authors.lastname: Dabholkar
authors.forename: Ganesh Baban
authors.initials: GB
authors.lastname: Mule
authors.forename: Suhas
authors.initials: S
authors.lastname: Kulkarni
mesh_terms: D001565:Benzoates / Q000097:blood* / Q000737:chemistry*; D001774:Blood Chemical Analysis / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods*; D000077588:Deferasirox; D003903:Deuterium / Q000737:chemistry*; D006801:Humans; D007502:Iron Chelating Agents / Q000032:analysis / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014230:Triazoles / Q000097:blood* / Q000737:chemistry*
chemical_list: D001565:Benzoates; D007502:Iron Chelating Agents; D014230:Triazoles; D003903:Deuterium; D000077588:Deferasirox
keywords: deferasirox; deuterium