title: Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins.
abstract: Translational control is a common mechanism used to regulate gene expression and occur in bacteria to mammals. Typically in translational control, an RNA-binding protein binds to a unique sequence in the mRNA to regulate protein synthesis by the ribosomes. Alternatively, a protein may bind to or modify a translation factor to globally regulate protein synthesis by the cell. Here, we review translational control by the fragile X mental retardation protein (FMRP), the absence of which causes the neurological disease, fragile X syndrome (FXS).
authors.affiliation: Department of Chemistry and Biochemistry, University of California at San Diego 9500 Gilman Drive, La Jolla, CA 92093-0314, USA.
authors.forename: Eileen
authors.initials: E
authors.lastname: Chen
authors.affiliation: Department of Chemistry and Biochemistry, University of California at San Diego 9500 Gilman Drive, La Jolla, CA 92093-0314, USA. Electronic address: sjoseph@ucsd.edu.
authors.forename: Simpson
authors.initials: S
authors.lastname: Joseph
mesh_terms: D000818:Animals; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000096:biosynthesis* / Q000235:genetics; D005600:Fragile X Syndrome / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D058990:Molecular Targeted Therapy; D014176:Protein Biosynthesis; D016601:RNA-Binding Proteins / Q000502:physiology
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D016601:RNA-Binding Proteins
keywords: Fragile X mental retardation protein; Fragile X syndrome; Neuron; RNA; Ribosome; Translation