title: Comparison of gamma camera-based methods to measure glomerular filtration rate in potential kidney donors.
abstract: BACKGROUND
  The aim of this study was to compare two gamma camera-based methods (Gates' method and Inoue's method) for measuring glomerular filtration rate (GFR) with Russell's two plasma sample clearance method (2-PSC), which was taken as the gold standard.
  
  
  METHODS
  In 94 healthy potential kidney donors (25 women and 69 men), GFR was measured by means of the 2-PSC method and was compared with Gates' and Inoue's methods of assessing GFR after technetium-99m-labeled diethylene triamine penta-acetic acid (⁹⁹ mTc-DTPA) injection.
  
  
  RESULTS
  Inoue's method showed no statistically significant difference (P=0.22) with the gold standard (2-PSC); there was good correlation (r=0.69) and least bias (-1.91 ml/min/1.73 m², root mean squared error=11.85 ml/min/1.73 m²). Gates' method showed weak correlation (r=0.36) and tended to underestimate GFR by 21% with bias of 25 ml/min/1.73 m² and root mean squared error of 29.97.
  
  
  CONCLUSIONS
  For a normal healthy adult population, Inoue's method gives a better measure of GFR in contrast to Gates' method when compared with 2-PSC method of GFR calculation.
authors.affiliation: aDepartment of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences, Islamabad bThe Kidney Centre, Rawalpindi, Pakistan.
authors.forename: Shabana
authors.initials: S
authors.lastname: Saeed
authors.forename: Smeera
authors.initials: S
authors.lastname: Saeed
authors.forename: Ambreen
authors.initials: A
authors.lastname: Khawar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yousuf
authors.forename: Tauseef
authors.initials: T
authors.lastname: Bukhari
authors.forename: Muhammad
authors.initials: M
authors.lastname: Sohaib
mesh_terms: D000328:Adult; D015902:Gamma Cameras; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000379:methods*; D014019:Tissue Donors