title: Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging.
abstract: In this work, an inorganic multifunctional nanovehicle was tailored as a carrier to deliver anticancer drug for tumor optical imaging and therapy. The nanovehicle could be used as a dually targeted drug nanovehicle by bonded magnetical (passive) and folic acid (active) targeting capabilities. In addition, it was developed using rhodamine 6G (R6G) as a fluorescence reagent, and an α-zirconium phosphate nanoplatform (Zr(HPO4)2·H2O, abbreviated as α-ZrP) as the anticancer drug nanovehicle. The novel drug-release system was designed and fabricated by intercalation of α-ZrP with magnetic Fe3O4 nanoparticles and anticancer drug 5-fluorouracil (5-FU), followed by reacting with a folate acid-chitosan-rhodamine6G (FA-CHI-R6G) complex, and then α-ZrP intercalated with Fe3O4 nanoparticles and 5-fluorouracil (5-FU) was successfully encapsulated into chitosan (CHI). The resultant multifunctional drug delivery system was characterized by scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray analysis, photoluminescence spectra, magnetometry, fluorescence microscopy imaging studies and other characterization methods. Simultaneously, the drug release in vitro on the obtained nanocomposites that exhibited a sustained release behavior was carried out in buffer solution at 37 °C, which demonstrated clearly that the nanocomposites shown a sustained release behavior. Meanwhile, cell culture experiments also indicated that the drug-release system had the potential to be used as an dually targeted drug nanovehicle into the tumor cells.
authors.affiliation: College of Chemistry & Chemical Engineering, Inner Mongolia University , Hohhot 010021, Inner Mongolia, China.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Yu
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Gao
authors.forename: Huricha
authors.initials: H
authors.lastname: Baigude
authors.forename: Xiao
authors.initials: X
authors.lastname: Hai
authors.forename: Renfei
authors.initials: R
authors.lastname: Zhang
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Gao
authors.forename: Beibei
authors.initials: B
authors.lastname: Shen
authors.forename: Zhao
authors.initials: Z
authors.lastname: Li
authors.forename: Zhibing
authors.initials: Z
authors.lastname: Tan
authors.forename: Haiquan
authors.initials: H
authors.lastname: Su
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005472:Fluorouracil / Q000737:chemistry / Q000494:pharmacology; D005492:Folic Acid / Q000737:chemistry; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012235:Rhodamines / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D012235:Rhodamines; C026188:rhodamine 6G; C027006:zirconium phosphate; D048271:Chitosan; D005492:Folic Acid; D015040:Zirconium; D005472:Fluorouracil; D052203:Ferrosoferric Oxide
keywords: controlled drug release; fluorescence imaging; multifunctional drug-delivery systems; α-ZrP nanoparticles