title: BTG3 upregulation induces cell apoptosis and suppresses invasion in esophageal adenocarcinoma.
abstract: B cell translocation gene 3 (BTG3) is a tumor suppressor by inhibiting cell proliferation, migration, and regulating cell cycle progression in several tumors. However, its role in esophageal adenocarcinoma (EAC) remains unknown. Here, we detected the expression of BTG3 in EAC tissues and subsequent progression. BTG3 expression was significant decreased in EAC tissues and cell lines detected by real-time RT-PCR and Western blot. Relationships of BTG3 with EAC clinicopathology were analyzed statistically. The decrease expression of BTG3 is associated with lymph node metastases. In vitro assay demonstrated that overexpression of BTG3 significantly suppressed colony formation and proliferation of EAC cells. The suppressed migration and invasion abilities found in BTG3-overexpressing EAC cells. Our findings suggested that BTG3 is suppressor in the progression of EAC.
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, Zhengzhou, 450001, China.
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Du
authors.forename: Pingping
authors.initials: P
authors.lastname: Liu
authors.forename: Wenqiao
authors.initials: W
authors.lastname: Zang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Chen
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D017209:Apoptosis / Q000235:genetics; D018797:Cell Cycle Proteins; D002465:Cell Movement; D049109:Cell Proliferation / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
chemical_list: C424522:BTG3 protein, human; D018797:Cell Cycle Proteins; D011506:Proteins