title: Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes.
abstract: The ongoing nanotech revolution has the potential to transform diagnostic and therapeutic methods. Stimuli-triggered nanotherapies based on remotely activated agents have become attractive alternatives to conventional chemotherapy. Herein, we designed an optimized smart nanoplatform based on dually loaded hybrid liposomes to achieve enhanced tumor therapy. The aqueous core was highly loaded with iron oxide nanoparticles, while the lipid bilayer was supplied with a photosensitizer payload. The double cargo translated into double functionality: generation of singlet oxygen under laser excitation and heat production under alternating magnetic field stimulation, coupling photodynamic therapy (PDT) to magnetic hyperthermia (MHT). These liposomes address both therapeutic agents within tumor cells, and the combined PDT/MHT therapy resulted in complete cancer cell death in vitro while total solid-tumor ablation was achieved in an in vivo rodent model.
authors.affiliation: †Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Corato
authors.affiliation: ‡Laboratoire PHENIX, Sorbonne Universités, UPMC, University Paris 06, UMR CNRS 8234, 4 place Jussieu 75005 Paris, France.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Béalle
authors.affiliation: †Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France.|§Inserm U970, Paris Cardiovascular Research Center-PARCC/Université Paris-Descartes, 75006 Paris, France.
authors.forename: Jelena
authors.initials: J
authors.lastname: Kolosnjaj-Tabi
authors.affiliation: †Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France.
authors.forename: Ana
authors.initials: A
authors.lastname: Espinosa
authors.affiliation: §Inserm U970, Paris Cardiovascular Research Center-PARCC/Université Paris-Descartes, 75006 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Clément
authors.affiliation: †Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France.
authors.forename: Amanda K A
authors.initials: AK
authors.lastname: Silva
authors.affiliation: ‡Laboratoire PHENIX, Sorbonne Universités, UPMC, University Paris 06, UMR CNRS 8234, 4 place Jussieu 75005 Paris, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Ménager
authors.affiliation: †Laboratoire Matière et Systèmes Complexes, UMR 7057, CNRS and University Paris Diderot, 75205 Paris cedex 13, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Wilhelm
mesh_terms: D055011:Ablation Techniques; D000818:Animals; D001692:Biological Transport; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D065546:Drug Liberation; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008081:Liposomes; D059346:Magnets; D008652:Mesoporphyrins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D008081:Liposomes; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C072269:temoporfin
keywords: cancer combined therapy; liposomes; magnetic hyperthermia; magnetic nanoparticles; photodynamic therapy; photosensitizer