title: Copper-catalyzed ortho-halogenation of arenes and heteroarenes directed by a removable auxiliary.
abstract: Copper-catalyzed ortho-halogenation of C(sp(2))-H bonds directed by a PIP directing group with NXS (X = Cl, Br, I) has been developed. The reaction is scalable and tolerates a broad range of functional groups and heteroarenes, providing an efficient access to halogenated arenes and heteroarenes.
authors.affiliation: Department of Chemistry, Zhejiang University, Hangzhou 310027, China. bfshi@zju.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011437:Propylamines / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D011437:Propylamines; D003300:Copper