title: Upregulation of miR-1280 expression in non-small cell lung cancer tissues.
abstract: BACKGROUND
  Non-small cell lung cancer (NSCLC) is a prolific and high-mortality disease with few effective treatments. Although the detection and surgical techniques for NSCLC continue to advance, the survival rate for the patients with NSCLC remains poor. Enhanced predictive biomarkers such as microRNAs (miRNAs) are needed at the time of diagnosis to better tailor therapies for patients. This study focused on the expression of miR-1280 in NSCLC tissues and distal normal tissues in order to explore the association between miR-1280 expression and NSCLC.
  
  
  METHODS
  A total of 72 newly diagnosed primary NSCLC patients were enrolled in this study. Quantitative real-time polymerase chain reaction (PCR) was performed to identify the expression level of miR-1280 in the NSCLC tissues and distal normal tissues of these patients.
  
  
  RESULTS
  The miR-1280 expression was significantly higher in the NSCLC tissues (0.084 ± 0.099) than distal normal tissues (0.014 ± 0.015, P = 0.009). In 54 patients (75%), the miR-1280 expression in the NSCLC tissues was upregulated (2-ΔΔct > 2), and no case showed a downregulation of miR-1280 expression.
  
  
  CONCLUSIONS
  The expression level of miR-1280 could be regarded as a biomarker for NSCLC.
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Xu
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.forename: Qi-Bin
authors.initials: QB
authors.lastname: Shen
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Ping
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Ma
authors.forename: Jing
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, Zhejiang 313000, China.
authors.forename: Li-Cheng
authors.initials: LC
authors.lastname: Dai
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D060888:Real-Time Polymerase Chain Reaction; D015854:Up-Regulation
chemical_list: D035683:MicroRNAs