title: PRIMARY ADRENAL LYMPHOMA: A SINGLE-CENTER EXPERIENCE.
abstract: OBJECTIVE
  To describe the clinical presentation, biochemistry, imaging features, and treatment outcome of patients with primary adrenal lymphoma (PAL) presenting to a single tertiary care center.
  
  
  METHODS
  We performed a retrospective analysis of case records of 7 patients diagnosed with PAL between January 2011 and May 2014 at our institution in Mumbai, India.
  
  
  RESULTS
  Median age of presentation in our series was 48 years (range, 41 to 60 years), with a male to female ratio of 6:1. Bilateral adrenal involvement was seen in 4 of 7 patients (58%). Adrenal insufficiency (AI) was seen in 3 of the 4 patients with bilateral involvement (75%). Computed tomography showed slight to moderate contrast enhancement of adrenal masses in 4 of 5 patients (80%). Diffuse, large, B-cell lymphoma (DLBCL) was the most common immunophenotype (85%). One patient died due to rapid disease progression even before starting chemotherapy. Six patients were treated with chemotherapy and/or external beam radiotherapy. After 1 year, 2 more patients had died, whereas 4 patients were in remission.
  
  
  CONCLUSIONS
  PAL should always be considered in differential diagnosis of bilateral adrenal mass with AI. DLBCL is the most common histologic subtype of PAL. Despite treatment, long-term prognosis of PAL remains poor.
authors.forename: Rajeev
authors.initials: R
authors.lastname: Kasaliwal
authors.forename: Manjunath
authors.initials: M
authors.lastname: Goroshi
authors.forename: Kranti
authors.initials: K
authors.lastname: Khadilkar
authors.forename: Ganesh
authors.initials: G
authors.lastname: Bakshi
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Rangarajan
authors.forename: Gaurav
authors.initials: G
authors.lastname: Malhotra
authors.forename: Anurag
authors.initials: A
authors.lastname: Lila
authors.forename: Tushar
authors.initials: T
authors.lastname: Bandgar
authors.forename: Nalini S
authors.initials: NS
authors.lastname: Shah
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D000328:Adult; D005260:Female; D006801:Humans; D007194:India; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies