title: Glomus tumor of the liver in a cow.
abstract: An 11-year-old Holstein-Friesian cow exhibited anorexia and jaundice. A large mass was found in the liver during necropsy. Macroscopically, the mass was composed of dark red multilobular tissue and a centrally located abscess, which was connected to the hepatic duct. Histologically, the mass consisted of proliferation of small neoplastic cells and was demarcated from the hepatic parenchyma by a thick region of granulation tissue. The neoplastic cells were predominantly arranged in solid sheets, but they also formed blood-filled cancellous structures, and proliferating foci were seen around blood vessels. Periodic acid-Schiff reaction demonstrated that a fine basement membrane-like structure surrounded the neoplastic cells. Immunohistochemically, the neoplastic cells were positive for vimentin and alpha smooth muscle actin and negative for cytokeratin, factor VIII-related antigen, chromogranin and desmin. Based on its histopathological features, the hepatic neoplasm was diagnosed as a primary glomus tumor. This is the first report about a primary glomus tumor of the liver in a cow.
authors.affiliation: Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Komagata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Shitamura
authors.forename: Shiori
authors.initials: S
authors.lastname: Chiba
authors.forename: Kotaro
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Inokuma
authors.forename: Takane
authors.initials: T
authors.lastname: Matsui
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D005260:Female; D005918:Glomus Tumor / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D007564:Japan; D008113:Liver Neoplasms / Q000473:pathology / Q000662:veterinary*; D010503:Periodic Acid-Schiff Reaction; D014746:Vimentin / Q000378:metabolism
chemical_list: D000199:Actins; D014746:Vimentin