title: Family history of breast and ovarian cancer and triple negative subtype in hispanic/latina women.
abstract: Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26-3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26-2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Anderson
authors.affiliation: University of Arizona, Tucson, AZ USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Thompson
authors.affiliation: University of Arizona, Tucson, AZ USA.
authors.forename: Betsy C
authors.initials: BC
authors.lastname: Wertheim
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA USA.
authors.forename: Lorena
authors.initials: L
authors.lastname: Martin
authors.affiliation: Maricopa Medical Center, Phoenix, AZ USA.
authors.forename: Ian K
authors.initials: IK
authors.lastname: Komenaka
authors.affiliation: Baylor College of Medicine, Houston, TX USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Bondy
authors.affiliation: Universidad of Guadalajara, Guadalajara, México.
authors.forename: Adrian
authors.initials: A
authors.lastname: Daneri-Navarro
authors.affiliation: Instituto Tecnológico de Sonora, Ciudad Obregón, México.
authors.forename: Maria Mercedes
authors.initials: MM
authors.lastname: Meza-Montenegro
authors.affiliation: Universidad of Sonora, Hermosillo, México.
authors.forename: Luis Enrique
authors.initials: LE
authors.lastname: Gutierrez-Millan
authors.affiliation: University of Texas M.D. Anderson Cancer Center, Houston, TX USA.
authors.forename: Abenaa
authors.initials: A
authors.lastname: Brewster
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA ; Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Madlensky
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA.
authors.forename: Malaika
authors.initials: M
authors.lastname: Tobias
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA ; Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA USA.
authors.forename: Loki
authors.initials: L
authors.lastname: Natarajan
authors.affiliation: Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA ; Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA USA.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Martínez
keywords: Family history; Hispanic; Risk factor heterogeneity; Triple negative breast cancer