title: Design and characterization of a conductive nanostructured polypyrrole-polycaprolactone coated magnesium/PLGA composite for tissue engineering scaffolds.
abstract: A novel biodegradable and conductive composite consisting of magnesium (Mg), polypyrrole-block-ploycaprolactone (PPy-PCL), and poly(lactic-co-glycolic acid) (PLGA) is synthesized in a core-shell-skeleton manner for tissue engineering applications. Mg particles in the composite are first coated with a conductive nanostructured PPy-PCL layer for corrosion resistance via the UV-induced photopolymerization method. PLGA matrix is then added to tailor the biodegradability of the resultant composite. Composites with different composition ratios are examined through experiments, and their material properties are characterized. The in vitro experiments on culture of 293FT-GFP cells show that the composites are suitable for cell growth and culture. Biodegradability of the composite is also evaluated. By adding PLGA matrix to the composite, the degrading time of the composite can last for more than eight weeks, hence providing a longer period for tissue formation as compared to Mg composites or alloys. The findings of this research will offer a new opportunity to utilize a conductive, nanostructured-coated Mg/PLGA composite as the scaffold material for implants and tissue regeneration.
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.|School of Instrument Science and Optoelectronic Engineering, Beihang University, Beijing, 100191, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
authors.forename: Henry K
authors.initials: HK
authors.lastname: Chu
authors.affiliation: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.
authors.forename: Dong
authors.initials: D
authors.lastname: Sun
mesh_terms: D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D049109:Cell Proliferation; D004553:Electric Conductivity; D048091:Guided Tissue Regeneration; D057809:HEK293 Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D011758:Pyrroles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C016240:polycaprolactone; D011100:Polyglycolic Acid; C067635:polypyrrole; D019344:Lactic Acid; D008274:Magnesium
keywords: PPy-PCL; conductive scaffold; magnesium; nanostructured coating; tissue engineering