title: Five years of stable disease with maintenance therapy using bevacizumab and tamoxifen in a patient with metastatic breast cancer.
abstract: Bevacizumab and Tamoxifen are valid therapeutic options for metastatic breast cancer (mBC) patients. In this report, we describe a 47 year old woman with mBC successfully treated with a maintenance therapy with Bevacizumab+Tamoxifen. A maintenance approach using 2 different drugs with different targets and mechanism of action, such as anti-angiogenic and anti-hormonal treatment is particularly intriguing because they affect different pathways involved in mBC progression. Further studies including a large number of patients are needed, in order to select women who could benefit from this maintenance approach.
authors.affiliation: a Medical Oncology Unit; University of Siena ; Siena , Italy.
authors.forename: Giandomenico
authors.initials: G
authors.lastname: Roviello
authors.forename: Edoardo
authors.initials: E
authors.lastname: Francini
authors.forename: Armando
authors.initials: A
authors.lastname: Perrella
authors.forename: Letizia
authors.initials: L
authors.lastname: Laera
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Mazzei
authors.forename: Susanna
authors.initials: S
authors.lastname: Guerrini
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
authors.forename: Daniele
authors.initials: D
authors.lastname: Marrelli
authors.forename: Roberto
authors.initials: R
authors.lastname: Petrioli
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D020533:Angiogenesis Inhibitors; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D000068258:Bevacizumab
keywords: bevacizumab; maintenance therapy; metastatic breast cancer; tamoxifen