title: [Tumour markers in chronic kidney disease].
abstract: Tumour markers are high molecular weight glycoproteins whose interpretation in the presence of chronic renal disease may be disturbed. Apart from the prostate specific antigen, human chorionic gonadotropin and α-fetoprotein, their levels rise with chronic renal failure. For some markers, such as carcinoembryonic antigen, carcinogen antigen (CA) 15-3, cytokeratin fragment 21-1 or calcitonin, a threshold may be defined in a population with chronic renal failure, which may allow their use in cancer surveillance. Others, such as CA125, CA19-9, squamous cell carcinoma and neurospecific enolase, have a high variability and their use in patients with chronic renal disease remains difficult.
authors.affiliation: Hôpital Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France. Electronic address: lucile.mercadal@psl.aphp.fr.
authors.forename: Lucile
authors.initials: L
authors.lastname: Mercadal
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018395:CA-19-9 Antigen / Q000032:analysis; D002116:Calcitonin / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000097:blood*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D002116:Calcitonin
keywords: Cancer; Dialyse péritonéale; Haemodialysis; Hémodialyse; Insuffisance rénale; Kidney failure; Marqueurs tumoraux; Peritoneal dialysis; Tumour markers