title: MicroRNA-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility: a meta-analysis based on East Asian population.
abstract: OBJECTIVE
  The relationship between microRNA (miR-146a) rs2910164G/C polymorphism and gastrointestinal cancer susceptibility is not consistent with each other of the published articles. The aim of this meta-analysis was to acquire a more precise effect of the association between the miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer.
  
  
  METHODS
  Through searching of the MedLine, Embase, China National Knowledge Infrastructure, and Wanfang databases. Case-control or cohort studies about the relationship between miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility were screened and included in this meta-analysis. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer risk by statistical software STATA-11.0.
  
  
  RESULTS
  Ten studies including 6473 gastrointestinal cancer patients and 7923 controls were identified and included in this meta-analysis. For recessive genetic model (CC vs. CG + GG), people with CG or GG is associated with the susceptibility of gastrointestinal cancer compared with genotype of CC (R = 0.73, 5% confidence interval [CI]: 0.55-0.97, [P = 0.03]); But for dominant model (CC + CG vs. GG) and homozygous model (CC vs. GG), no association of the miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility were found (dominant: Odds ratio [OR] =0.94, 95% CI: 0.82-1.03, [P = 0.37]; homozygous: OR = 0.85, 95% CI: 0.71-1.03, [P = 0.10]). Sub-group analysis, for homozygous model, people with GG genotype had increased risk of developing colorectal cancer (OR = 0.77, 95% CI: 0.64-0.93, [P = 0.008]).
  
  
  CONCLUSIONS
  No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis. But for homozygous model, people with GG genotype may have increased risk of developing colorectal cancer.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Chen
authors.forename: Xin-Guang
authors.initials: XG
authors.lastname: Cao
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Chen
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Ma
authors.forename: Wen-Ying
authors.initials: WY
authors.lastname: Deng
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jin-Xi
authors.initials: JX
authors.lastname: Huang
authors.affiliation: Department of Medical Gastroenterology, Cancer Hospital of Henan Province, The Affiliated Cancer Hospital of Zhengzhou University, Henan 450008, China.
authors.forename: Su-Xia
authors.initials: SX
authors.lastname: Luo
authors.forename: Er-Jiang
authors.initials: EJ
authors.lastname: Zhao
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs