title: 18F-FDG PET/CT in patients with adult-onset Still's disease.
abstract: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) has become useful for the detection and diagnosis of inflammatory conditions, including rheumatic diseases, immunoglobulin (Ig) G4-related disease and giant cell arteritis. However, few articles based on small sample sizes (n = 7) diagnosed as adult-onset Still's disease (AOSD) have been published. The study aim was to observe the reliable characteristics and usefulness of (18)F-FDG PET/CT for the evaluation of consecutive patients with AOSD. Eligible patients were selected from among those who had undergone (18)F-FDG PET/CT between May 2007 and June 2014. Twenty-six consecutive AOSD patients were recruited retrospectively according to criteria set by Yamaguchi et al. All patients underwent evaluation by (18)F-FDG PET/CT. The characteristics and usefulness of (18)F-FDG PET/CT for evaluation of consecutive patients with AOSD were evaluated. All 26 patients had (18)F-FDG-avid lesion(s) related to their particular disease. Diffuse and homogeneous accumulation of (18)F-FDG was seen in the bone marrow (26/26; 100 %; maximum standardized uptake (SUVmax), 2.10-6.73) and spleen (25/26; 96.15 %). The SUVmax of affected lymph nodes was 1.3-9.53 (mean ± SD, 4.12 ± 2.24). The SUVmax and size factors (maximum diameter and areas) of affected lymph nodes were significantly different (P = 0.033 and P = 0.012, respectively). (18)F-FDG PET/CT showed the general distribution of (18)F-FDG accumulation. This factor helped to exclude malignant disease and aided the diagnosis of AOSD (42.3 %) in 11 cases when combined with clinical features and aided decisions regarding appropriate biopsy sites, such as the lymph nodes (n = 9) and bone marrow (n = 13). (18)F-FDG PET/CT is a unique imaging method for the assessment of metabolic activity throughout the body in subjects with AOSD. Characteristics or patterns of AOSD observed on (18)F-FDG PET/CT can be used for the indication and diagnosis or to guide the clinical management of ASOD.
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China.
authors.forename: Meng-Jie
authors.initials: MJ
authors.lastname: Dong
authors.affiliation: Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Women's Reproductive Health Key Laboratory of Zhejiang Province, Zhejiang, 310003, People's Republic of China.
authors.forename: Cai-Qin
authors.initials: CQ
authors.lastname: Wang
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China.
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Wang
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Sun
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China. dmjlzfwgl@126.com.
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Liu
authors.affiliation: Rheumatology Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, People's Republic of China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000000981:diagnostic imaging*; D015331:Cohort Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013154:Spleen / Q000000981:diagnostic imaging*; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG PET/CT; Adult-onset Still’s disease; Bone marrow; Diagnosis; Lymph nodes