title: [Studying the effect of Dimebon and NT-1505 on microviscosity of mice brain synaptosomal membranes in vivo by EPR spin labeling method].
abstract: In this work membrane fluidity alterations in synaptosomes, isolated from mice brain tissue, at chronic administration of neuroprotectors Dimebon and NT-1505 in vivo were studied. Membrane microviscosity was measured by electron paramagnetic resonance spin labeling of 2,2,6,6-tetramet-hyl-4-capryloyl-oxylpiperidine-l-oxyl (lipid probe) and 5,6-benzo-2,2,6,6-tetramethyl-1,2,3,4-tetrahydro-gamma-carboline-3-oxyl (near protein probe). It was shown that the neuroprotectors Dimebon and NT-1505 affect a membrane structure. Despite the difference in membrane structures, fluidity of the lipid bilayer in time returned to control values.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Gerasimov
authors.forename: O V
authors.initials: OV
authors.lastname: Nevrova
authors.forename: V V
authors.initials: VV
authors.lastname: Kasparov
authors.forename: A N
authors.initials: AN
authors.lastname: Goloshchapov
authors.forename: E B
authors.initials: EB
authors.lastname: Burlakova
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D004578:Electron Spin Resonance Spectroscopy; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D013113:Spin Labels; D013570:Synaptic Membranes / Q000737:chemistry* / Q000187:drug effects; D013574:Synaptosomes / Q000737:chemistry* / Q000187:drug effects; D014783:Viscosity
chemical_list: D007211:Indoles; D018696:Neuroprotective Agents; D013113:Spin Labels; C010119:latrepirdine