title: Olfactory perceptual learning requires action of noradrenaline in the olfactory bulb: comparison with olfactory associative learning.
abstract: Noradrenaline contributes to olfactory-guided behaviors but its role in olfactory learning during adulthood is poorly documented. We investigated its implication in olfactory associative and perceptual learning using local infusion of mixed α1-β adrenergic receptor antagonist (labetalol) in the adult mouse olfactory bulb. We reported that associative learning, as opposed to perceptual learning, was not affected by labetalol infusions in the olfactory bulb. Accordingly, this treatment during associative learning did not affect the survival of bulbar adult-born neurons. Altogether, our results suggest that the noradrenergic system plays different parts in specific olfactory learning tasks and their neurogenic correlates.
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vinera
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Kermen
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Sacquet
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Didier
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mandairon
authors.affiliation: INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Neuroplasticity and Neuropathology of Olfactory Perception Team, Lyon, F-69000, France University of Lyon, F-69000, France University Lyon 1, Villeurbanne, F-69000, France marion.richard@univ-lyon1.fr.
authors.forename: Marion
authors.initials: M
authors.lastname: Richard
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009638:Norepinephrine / Q000502:physiology*; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*
chemical_list: D007741:Labetalol; D009638:Norepinephrine