title: Modelling the risk of airborne infectious disease using exhaled air.
abstract: In this paper we develop and demonstrate a flexible mathematical model that predicts the risk of airborne infectious diseases, such as tuberculosis under steady state and non-steady state conditions by monitoring exhaled air by infectors in a confined space. In the development of this model, we used the rebreathed air accumulation rate concept to directly determine the average volume fraction of exhaled air in a given space. From a biological point of view, exhaled air by infectors contains airborne infectious particles that cause airborne infectious diseases such as tuberculosis in confined spaces. Since not all infectious particles can reach the target infection site, we took into account that the infectious particles that commence the infection are determined by respiratory deposition fraction, which is the probability of each infectious particle reaching the target infection site of the respiratory tracts and causing infection. Furthermore, we compute the quantity of carbon dioxide as a marker of exhaled air, which can be inhaled in the room with high likelihood of causing airborne infectious disease given the presence of infectors. We demonstrated mathematically and schematically the correlation between TB transmission probability and airborne infectious particle generation rate, ventilation rate, average volume fraction of exhaled air, TB prevalence and duration of exposure to infectors in a confined space.
authors.affiliation: Computational Biology Group, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors.forename: Chacha M
authors.initials: CM
authors.lastname: Issarow
authors.affiliation: Computational Biology Group, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors.forename: Nicola
authors.initials: N
authors.lastname: Mulder
authors.affiliation: The Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, South Africa.
authors.forename: Robin
authors.initials: R
authors.lastname: Wood
mesh_terms: D000391:Air Microbiology; D016902:Air Pollution, Indoor; D003141:Communicable Diseases / Q000635:transmission; D045853:Exhalation; D006801:Humans; D008954:Models, Biological; D015995:Prevalence; D011336:Probability; D012119:Respiration; D014376:Tuberculosis / Q000635:transmission*
keywords: Deposition fraction; Infectious particles; Mathematical model; Threshold level