title: Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway.
abstract: As the eighth most common malignant tumour worldwide, oesophageal cancer (OC) is often diagnosed during the metastasis of its advanced stage. Interleukin (IL)-23 is an immunomodulatory cytokine that has recently been identified as a cancer-associated factor. However, the role of IL-23 in the evolution of OC remains unclear. In the present study, we found that IL-23 was significantly expressed in the tumours of OC patients suffering metastasis and demonstrated that IL-23 contributed to epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin pathway, promoting the migration and invasion of OC cells. In conclusion, IL-23 plays a pivotal role in the development of OC via EMT.
authors.affiliation: Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Deyu
authors.initials: D
authors.lastname: Chen
authors.affiliation: 1] Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China [2] Department of Oncology, Jintan Hospital Affiliated to Jiangsu University, Changzhou. 213200, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Shenzha
authors.initials: S
authors.lastname: Liu
authors.affiliation: Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Su
authors.affiliation: Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Guohu
authors.initials: G
authors.lastname: Han
authors.affiliation: Department of Nuclear Medicine, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Hongli
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Nuclear Medicine, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zheng
authors.affiliation: Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Yuepeng
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: 1] Institute of Oncology, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China [2] Department of Nuclear Medicine, the Hospital Affiliated to Jiangsu University, Zhenjiang. 212001, China.
authors.forename: Chaoming
authors.initials: C
authors.lastname: Mao
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D018920:Coculture Techniques; D058750:Epithelial-Mesenchymal Transition; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D053759:Interleukin-23 / Q000502:physiology*; D008207:Lymphatic Metastasis; D008297:Male; D008819:Mice, Nude; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured; D060449:Wnt Signaling Pathway
chemical_list: D053759:Interleukin-23