title: Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential.
abstract: Excessive accumulation of pro-oxidant metals, observed in affected brain regions, has consistently been implicated as a contributor to the brain pathology including neurodegenerative diseases and acute injuries such as stroke. Furthermore, the potential interactions between metal toxicity and other commonly associated etiological factors, such as misfolding/aggregation of amyloidogenic proteins or genomic damage, are poorly understood. Decades of research provide compelling evidence implicating metal overload in neurological diseases and stroke. However, the utility of metal toxicity as a therapeutic target is controversial, possibly due to a lack of comprehensive understanding of metal dyshomeostasis-mediated neuronal pathology. In this article, we discuss the current understanding of metal toxicity and the challenges associated with metal-targeted therapies.
authors.affiliation: Department of Radiation Oncology, Houston Methodist Research Institute.
authors.forename: Joy
authors.initials: J
authors.lastname: Mitra
authors.affiliation: Houston Methodist Neurological Institute.
authors.forename: Velmarini
authors.initials: V
authors.lastname: Vasquez
authors.affiliation: Institute of Academic Medicine, Houston Methodist Hospital, Houston Texas 77030, USA.
authors.forename: Pavana M
authors.initials: PM
authors.lastname: Hegde
authors.affiliation: Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
authors.affiliation: Centre for Neuroscience, Institute for Scientific Research and Technology Services (INDICASAT-AIP), City of Knowledge, Republic of Panama.
authors.forename: Sankar
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Kent
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
authors.forename: Kosagi S
authors.initials: KS
authors.lastname: Rao
authors.affiliation: Department of Neurology, Baylor College of Medicine and Center for Translational Research on Inflammatory Diseases Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA.
authors.forename: Muralidhar L
authors.initials: ML
authors.lastname: Hegde