title: [Heart and liver fibrosis: the components of a single equation].
abstract: Myocardial fibrosis plays a key role in the pathogenesis of cardiovascular diseases. The chronic pressure overload of the heart activates collagen that leads to its excessive accumulation, fibrosis and cardiac hypertrophy. Myocardial injury is often accompanied by liver damage. These two processes are closely linked. One of the links of this chain is the activation of the renin-angiotensin-aldosterone system (RAAS). There is impressive evidence base for drugs that block the RAAS, and thus break the vicious cycle of cardiovascular continuum. Fibrogenesis is nonspecific process and prospect of drug application affecting the activity of the RAAS may be useful for fibrosis prevention not only for the heart and liver, but also for other organs.
authors.forename: O M
authors.initials: OM
authors.lastname: Drapkina
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Drapkina
mesh_terms: D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D005355:Fibrosis / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D006334:Heart Function Tests; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D012084:Renin-Angiotensin System / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002317:Cardiovascular Agents; D003094:Collagen