title: Polyoxometalate-Based Organic-Inorganic Hybrids as Antitumor Drugs.
abstract: Polyoxometalates (POMs) have shown encouraging antitumor activity. However, their cytotoxicity in normal cells and unspecific interactions with biomolecules are two major obstacles that impede the practical applications of POMs in clinical cancer treatment. Derivatization of POMs with more biocompatible organic ligands is expected to cause a synergetic effect and achieve improved bioactivity and biospecificity. Herein, the synthesis of an amphiphilic organic-inorganic hybrid is reported by grafting a long-chain organoalkoxysilane lipid onto a POM. The amphiphilic POM hybrid could spontaneously assemble into the vesicles and exhibits enhanced antitumor activity for human colorectal cancer cell lines (HT29) compared to that of parent POMs. This detailed study reveals that the amphiphilic nature of POM hybrids enables the as-formed vesicles to easily bind to the cell membranes and then be uptaken by the cells, thus leading to a substantial increase in antitumor activity. Such prominent antitumor action is mostly accomplished via cell apoptosis, which ultimately results in cell death. Our finding demonstrates that novel POM hybrids-based drugs with increased bioactivity could be obtained by decorating POMs with selective organic ligands.
authors.affiliation: Key Laboratory of Microsystems and Micronanostructures Manufacturing (Harbin Institute of Technology), Ministry of Education, Harbin, 150080, P.R. China.|School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.affiliation: Key Laboratory of Microsystems and Micronanostructures Manufacturing (Harbin Institute of Technology), Ministry of Education, Harbin, 150080, P.R. China.
authors.forename: Hanqin
authors.initials: H
authors.lastname: Gao
authors.affiliation: Key Laboratory of Microsystems and Micronanostructures Manufacturing (Harbin Institute of Technology), Ministry of Education, Harbin, 150080, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yan
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P.R. China.
authors.forename: Shouzhu
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Microsystems and Micronanostructures Manufacturing (Harbin Institute of Technology), Ministry of Education, Harbin, 150080, P.R. China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150080, P.R. China.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Key Laboratory of Microsystems and Micronanostructures Manufacturing (Harbin Institute of Technology), Ministry of Education, Harbin, 150080, P.R. China.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D017304:Annexin A5 / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D000067493:Dynamic Light Scattering; D004705:Endocytosis / Q000187:drug effects; D019073:HT29 Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D007287:Inorganic Chemicals / Q000494:pharmacology*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry; D009930:Organic Chemicals / Q000494:pharmacology*; D011419:Propidium / Q000378:metabolism; D020349:Surface Plasmon Resonance; D017973:Tungsten Compounds / Q000494:pharmacology*; D000099294:Polyoxometalates
chemical_list: D017304:Annexin A5; D000970:Antineoplastic Agents; D007287:Inorganic Chemicals; D008051:Lipid Bilayers; D009930:Organic Chemicals; D011419:Propidium; D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates
keywords: antitumor; composites; hybrid materials, biomaterials; organic-inorganic hybrid materials; polyoxometalates