title: Exploring Microstructural Changes in Structural Analogues of Ibuprofen-Hosted In Situ Gelling System and Its Influence on Pharmaceutical Performance.
abstract: The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.
authors.affiliation: Poona College of Pharmacy, Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, 411 038, India.|Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India.
authors.forename: Sharvil S
authors.initials: SS
authors.lastname: Patil
authors.affiliation: Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India.
authors.forename: Edakkal
authors.initials: E
authors.lastname: Venugopal
authors.affiliation: Polymer Science and Engineering Division, National Chemical Laboratory, Pune, 411 008, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Bhat
authors.affiliation: Poona College of Pharmacy, Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, 411 038, India. krmahadik@rediffmail.com.
authors.forename: Kakasaheb R
authors.initials: KR
authors.lastname: Mahadik
authors.affiliation: Centre for Pharmaceutical Engineering Science, University of Bradford, Bradford, West Yorkshire, BD7 1DP, UK. a.paradkar1@bradford.ac.uk.
authors.forename: Anant R
authors.initials: AR
authors.lastname: Paradkar
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D005782:Gels; D057927:Hydrophobic and Hydrophilic Interactions; D007052:Ibuprofen / Q000737:chemistry*; D007700:Kinetics; D050866:Liquid Crystals; D008859:Microscopy, Polarization; D008956:Models, Chemical; D015394:Molecular Structure; D012212:Rheology; D053838:Scattering, Small Angle; D012995:Solubility; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004655:Emulsions; D005782:Gels; D013501:Surface-Active Agents; D014867:Water; D007052:Ibuprofen
keywords: flurbiprofen; hexagonal phase; ibuprofen; ketoprofen; liquid crystal; sustained drug release