title: A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(II) phthalocyanine containing octa-sulphonates.
abstract: A novel zinc(II) phthalocyanine bearing octa-sulphonates has been prepared, which is non-aggregated in water, highly photoactive and low dark-toxic. More interestingly, it exhibits specific affinity to macrophages via the scavenger receptor-A, and can selectively accumulate in tumour sites.
authors.affiliation: College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou 350116, China. jdhuang@fzu.edu.cn.
authors.forename: Xing-Shu
authors.initials: XS
authors.lastname: Li
authors.forename: Mei-Rong
authors.initials: MR
authors.lastname: Ke
authors.forename: Miao-Fen
authors.initials: MF
authors.lastname: Zhang
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Tang
authors.forename: Bi-Yuan
authors.initials: BY
authors.lastname: Zheng
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D054833:Isoindoles; D008264:Macrophages / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D013451:Sulfonic Acids; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine