title: Microwave (MW) irradiated Ugi four-component reaction (Ugi-4CR): Expedited synthesis of steroid-amino acid conjugates--A novel class of hybrid compounds.
abstract: Microwave (MW) assisted chemical reactions are currently gaining considerable importance in organic synthesis to contribute in green technology. Considering the importance of peptidomimetic steroid-amino acid conjugates - a novel class of hybrid compounds having diverse biological properties, we report here synthesis of these compounds of alanine and valine methyl esters with seco-steroids (A, B and D ring cleavage) in expedited way by MW promoted Ugi-four-component reaction (Ugi-4CR).
authors.affiliation: Natural Products Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785 006, Assam, India.
authors.forename: Preetismita
authors.initials: P
authors.lastname: Borah
authors.affiliation: Natural Products Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785 006, Assam, India.
authors.forename: Juri Moni
authors.initials: JM
authors.lastname: Borah
authors.affiliation: Natural Products Chemistry Division, CSIR-North East Institute of Science & Technology, Jorhat 785 006, Assam, India. Electronic address: pritishchowdhury@yahoo.com.
authors.forename: Pritish
authors.initials: P
authors.lastname: Chowdhury
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D008872:Microwaves; D057786:Peptidomimetics / Q000138:chemical synthesis / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000596:Amino Acids; D057786:Peptidomimetics; D013256:Steroids
keywords: Artificial enzymes; Multi component reactions; Peptidomimetics; Phospholipid membranes; Steroid–amino acid conjugates; Ugi-4CR