title: Metal oxide-coating PMMA or Talc as a new IR blocker inhibits IR-induced decrease of collagens in human dermal fibroblasts.
abstract: OBJECTIVE
  The purpose of this study was whether P/M or T/M inhibits IR-induced decrease of collagens in human dermal fibroblasts, using P/M or T/M blocked near-IR (NIR) transmittance significantly in spectrophotometer measurement.
  
  
  METHODS
  As metal oxides are effective inorganic molecules for intercepting IR radiation, we have developed metal oxide-coating PMMA (P/M) or Talc (T/M) as a new IR blocker. Inhibitory effect of the new IR blocker on collagen degradation was measured by gene and protein expressions of procollagens and MMPs, respectively, in IR-irradiated Hs68 cell line.
  
  
  RESULTS
  Using P/M or T/M inhibited IR-induced increases of MMP-1, MMP-3 and MMP-9, and IR-induced decreases of type 1 and 4 procollagen in a dose-dependent manner in dermal fibroblasts. In addition, using both P/M and T/M blocked the increase of cell media temperature induced by IR lamp.
  
  
  CONCLUSIONS
  The results suggest that P/M or T/M can inhibit decrease of collagens by blocking IR-induced heat transmission in human dermal fibroblasts.
authors.affiliation: Cosmax R&I Center, 602, Pangyo inno valley E, 255, Pangyo-ro, Bungdang-gu, Seongnam-si, Gyeonggi-do, Korea.
authors.forename: J-J
authors.initials: JJ
authors.lastname: Nam
authors.affiliation: Cosmax R&I Center, 602, Pangyo inno valley E, 255, Pangyo-ro, Bungdang-gu, Seongnam-si, Gyeonggi-do, Korea.
authors.forename: K-E
authors.initials: KE
authors.lastname: Lee
authors.affiliation: Cosmax R&I Center, 602, Pangyo inno valley E, 255, Pangyo-ro, Bungdang-gu, Seongnam-si, Gyeonggi-do, Korea.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D002460:Cell Line; D003094:Collagen / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007259:Infrared Rays; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008670:Metals; D010087:Oxides; D019904:Polymethyl Methacrylate / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared
chemical_list: D008670:Metals; D010087:Oxides; D003094:Collagen; D019904:Polymethyl Methacrylate; D020782:Matrix Metalloproteinases
keywords: IR blocker; MMPs; infrared; procollagens; skin aging