title: Regulatory T cells and their prognostic value in hepatopancreatobiliary tumours.
abstract: OBJECTIVE
  The aim of this study was to determine the prognostic values of Foxp3+ Treg cells, CD4+ Tcells and CD8+ T cells in cancer cases of gallbladder, pancreas and liver.
  
  
  METHODS
  This study included 20 patients with gallbladder cancer, 25 patients with pancreatic cancer and 8 patients with liver cancer. Foxp3, CD4 and CD8 were immunohistochemically evaluated and compared with histopathological and clinical prognostic parameters.
  
  
  RESULTS
  Foxp3, CD4 and CD8 expression levels were significantly higher in peritumoral areas than in intratumoral areas in patients with gallbladder, pancreas, liver cancers (p<0,05). Positivity of Foxp3, CD4 and CD8 was correlated with advanced stage (p<0,05), poor differentiation, lymphovascular invasion, perineural invasion, advanced age. Patients with high positivity of Foxp3 had a shorter disease free survival (p<0,05).
  
  
  CONCLUSIONS
  Our results indicate that the ratio of Tregs/T helper cells (Foxp3+/CD4+) cells was higher in intratumoral area in hepatopancreatobiliary tumors. We conclude that intratumoral inlamatory cells might work for cancer cells, besides peritumoral cells work against cancer cells.
authors.forename: Halil Hakan
authors.initials: HH
authors.lastname: Ozgur
authors.forename: Ayse Pinar
authors.initials: AP
authors.lastname: Ercetin
authors.forename: Nuket
authors.initials: N
authors.lastname: Eliyatkin
authors.forename: Asli
authors.initials: A
authors.lastname: Seren
authors.forename: Ali
authors.initials: A
authors.lastname: Kupelioglu
authors.forename: Ragip
authors.initials: R
authors.lastname: Ortac
authors.forename: Gulden
authors.initials: G
authors.lastname: Diniz
authors.forename: Safiye
authors.initials: S
authors.lastname: Aktas
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D051858:Forkhead Transcription Factors / Q000032:analysis; D005706:Gallbladder Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000737:chemistry / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000737:chemistry / Q000276:immunology*; D013997:Time Factors; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors