title: How to mend a broken heart: adult and induced pluripotent stem cell therapy for heart repair and regeneration.
abstract: The recently developed ability to differentiate primary adult stem cells and induced pluripotent stem cells (iPSCs) into cardiomyocytes is providing unprecedented opportunities to produce an unlimited supply of cardiomyocytes for use in patients with heart disease. Here, we examine the evidence for the preclinical use of such cells for successful heart regeneration. We also describe advances in the identification of new cardiac molecular and cellular targets to induce proliferation of cardiomyocytes for heart regeneration. Such new advances are paving the way for a new innovative drug development process for the treatment of heart disease.
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, Leipzig D-04103, Germany.
authors.forename: Marie
authors.initials: M
authors.lastname: Wegener
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, Leipzig D-04103, Germany.
authors.forename: Augustinus
authors.initials: A
authors.lastname: Bader
authors.affiliation: Centre for Biotechnology and Biomedicine, Department of Cell Techniques and Applied Stem Cell Biology, Medical Faculty of University of Leipzig, Deutscher Platz 5, Leipzig D-04103, Germany. Electronic address: shibashish.giri@bbz.uni-leipzig.de.
authors.forename: Shibashish
authors.initials: S
authors.lastname: Giri
mesh_terms: D053687:Adult Stem Cells / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D018507:Gene Expression Regulation, Developmental; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism / Q000637:transplantation*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D020127:Recovery of Function; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D015398:Signal Transduction