title: C3 Polymorphism Influences Circulating Levels of C3, ASP and Lipids in Schizophrenic Patients.
abstract: Excessive activation of complement is associated with many diseases including schizophrenia. Investigation of C3 polymorphisms, circulating C3, cleavage product ASP/C3adesArg, and lipid metabolism. Cross-sectional analysis. C3 genotyping (CC vs GG for R102L) was performed on 434 Tunisian people consisting of 272 schizophrenic (SZ) patients and 162 control subjects. In a age- and gender-matched subgroups of the three genotypes (131 SZ and 112 NOR), plasma triglycerides, total cholesterol (C), LDL-C, HDL-C, ASP, and complement C3 were measured. C3 gene polymorphism influences BMI and plasma C3, ASP, triglyceride, total cholesterol, LDL-C and HDL-C among SZ patients (p < 0.05-0.0001), with increasing values demonstrated from CC (common form) to CG (heterozygote form) to GG (rare homozygote) forms. Significant correlations between plasma C3 and BMI, triglyceride, HDL-C and ASP (p < 0.05-0.0001) were observed, while ASP correlated with BMI and LDL-C (p = 0.005, p = 0.001, respectively) in SZ patients. Further, proportional conversion of C3 to ASP (%ASP/C3) also increased (p < 0.0001, GG>CG>CC). C3 polymorphisms and plasma C3, ASP and %ASP/C3 correlated with lipid parameters in this SZ population, suggesting that factors predisposing patients to schizophrenia are permissive for complement pathway activation and dyslipidemic influences.
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Québec, Université Laval, Y4332, 2725 Chemin Ste-Foy, Québec, QC, G1V 4G5, Canada.
authors.forename: Mohamed Jalloul
authors.initials: MJ
authors.lastname: Nsaiba
authors.forename: Marc
authors.initials: M
authors.lastname: Lapointe
authors.forename: Hajer
authors.initials: H
authors.lastname: Mabrouk
authors.forename: Wahiba
authors.initials: W
authors.lastname: Douki
authors.forename: Lotfi
authors.initials: L
authors.lastname: Gaha
authors.forename: Louis
authors.initials: L
authors.lastname: Pérusse
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
authors.forename: Besma Bel Hadj
authors.initials: BB
authors.lastname: Jrad
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
mesh_terms: D015415:Biomarkers / Q000097:blood; D003176:Complement C3 / Q000235:genetics* / Q000378:metabolism*; D015926:Complement C3a / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology; D008055:Lipids / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D014416:Tunisia / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D003176:Complement C3; D008055:Lipids; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a