title: Synthesis and evaluation of the diarylthiourea analogs as novel anti-cancer agents.
abstract: Ten p-nitrodiarylthiourea analogs were designed, synthesized and evaluated in breast (MCF-7, T-47D, MDA-MB-453) and prostate (DU-145, PC-3, LNCaP) cancer cell lines for their anticancer activities. The majority of the compounds were able to inhibit the growth of these six cancer cell lines at low micromolar concentrations. Compound 7 was found to be the most potent anticancer agent in this series with GI50 values of 3.16μM for MCF-7, 2.53μM for T-47D, 4.77μM for MDA-MB-453 breast cancer lines and 3.54μM for LNCaP prostate cancer cell line. These GI50 values were comparable to the parent compound, SHetA2.
authors.affiliation: College of Pharmacy, Touro University-California, Vallejo, CA 94592, USA. Electronic address: shengquan.liu@tu.edu.
authors.forename: Shengquan
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Touro University-California, Vallejo, CA 94592, USA; Department of Natural Science and Mathematics, Dominican University of California, San Rafael, CA 94901, USA.
authors.forename: Maggie C
authors.initials: MC
authors.lastname: Louie
authors.affiliation: College of Pharmacy, Touro University-California, Vallejo, CA 94592, USA.
authors.forename: Vanishree
authors.initials: V
authors.lastname: Rajagopalan
authors.affiliation: Department of Basic Science, Touro University-California, Vallejo, CA 94592, USA.
authors.forename: Guangyan
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Department of Natural Science and Mathematics, Dominican University of California, San Rafael, CA 94901, USA.
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Ponce
authors.affiliation: College of Pharmacy, Touro University-California, Vallejo, CA 94592, USA.
authors.forename: Tran
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Department of Natural Science and Mathematics, Dominican University of California, San Rafael, CA 94901, USA.
authors.forename: Linda
authors.initials: L
authors.lastname: Green
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D061986:MCF-7 Cells; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D013890:Thiourea
keywords: Anticancer agents; Breast cancer; Diarylthiourea analogs; Prostate cancer; SHetA2