title: The biomarker and therapeutic potential of miRNA in Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common cause of dementia. Currently, a clinical diagnosis of AD is based on evidence of both cognitive and functional decline. Progression is monitored by detailed clinical evaluations over many months to years. It is increasingly clear that to advance disease-modifying therapies for AD, patients must be identified and treated early, before obvious cognitive and functional changes. In addition, better methods are needed to sensitively monitor progression of disease and therapeutic efficacy. Therefore, considerable research has focused on characterizing biomarkers that can identify the disease early as well as accurately monitor disease progression. miRNA offer a unique opportunity for biomarker development. Here, we review research focused on characterizing miRNA as potential biomarkers and as a treatment for disease.
authors.affiliation: Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Bekris
authors.forename: James B
authors.initials: JB
authors.lastname: Leverenz
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Alzheimer's disease; biomarker; miRNA; miRNA profiling; neurodegenerative disease; oligonucleotide therapeutics