title: Pyrrole-coupled salicylimine-based fluorescence "turn on" probe for highly selective recognition of Zn²⁺ ions in mixed aqueous media: Application in living cell imaging.
abstract: Cation sensing behaviour of a pyrrole-based derivative (2-hydroxyl 3 methyl 6 isopropyl benzaldehyde}-3,4-dimethyl-1H-pyrrole-2-carbohydrazide (receptor 3) has been explored and is found to be selective towards Zn(2+) over a variety of tested cations. The receptor 3 has shown high selectivity and sensitivity towards Zn(2+) over the other alkali, alkaline earth and transition metal ions. In the presence of Zn(2+), absorption band of receptor 3 has shown the red shift. The sensing behaviour has been suggested to continue via enhancement process which has further been supported by UV-vis absorption and theoretical density functional theory (DFT) calculations indicating the formation of a 1:1 complex between the pyrrole based receptor 3 and Zn(2+). The present work is presenting a highly selective dual channel colorimetric sensor for zinc with great sensitivity. The developed sensor was successfully applied to image intracellular Zn(2+) in living cells.
authors.affiliation: School of Chemical Sciences, North Maharashtra University, Jalgaon, 425001, (MS), India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Bhosale
authors.forename: Umesh
authors.initials: U
authors.lastname: Fegade
authors.forename: Banashree
authors.initials: B
authors.lastname: Bondhopadhyay
authors.forename: Simanpreet
authors.initials: S
authors.lastname: Kaur
authors.forename: Narinder
authors.initials: N
authors.lastname: Singh
authors.forename: Anupam
authors.initials: A
authors.lastname: Basu
authors.forename: Rajesh
authors.initials: R
authors.lastname: Dabur
authors.forename: Ratnamala
authors.initials: R
authors.lastname: Bendre
authors.forename: Anil
authors.initials: A
authors.lastname: Kuwar
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006834:Hydrazines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000032:analysis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D006834:Hydrazines; D011758:Pyrroles; D015032:Zinc
keywords: (2-hydroxyl 3 methyl 6 isopropyl benzaldehyde}-3,4-dimethyl-1H-pyrrole-2-carbohydrazide (receptor 3); UV-vis absorption; Zn2+; cell image; density functional theory (DFT)