title: Fish oil N-3 fatty acids increase adiponectin and decrease leptin levels in patients with systemic lupus erythematosus.
abstract: Cardiovascular disease (CVD) has emerged as an important cause of death in patients with systemic lupus erythematosus (SLE). Reduced adiponectin and elevated leptin levels may contribute to CVD in SLE patients. The purpose of this study was to verify the effects of fish oil (FO) on adiponectin and leptin in patients with SLE. Biochemical and disease activity analysis were performed. Patients with SLE were divided in two groups: patients who used fish oil for four months and patients who did not use fish oil. Patients with SLE who used FO had a significant decrease in SLE disease activity index (SLEDAI) score (p ˂ 0.023) in relation to baseline. SLE patients who used fish oil had increased adiponectin levels (p ˂ 0.026) and decreased leptin levels (p ˂ 0.024) compared to baseline values, whereas there were no differences in adiponectin and leptin levels in patients with SLE who did not use fish oil. In conclusion, the findings of increased serum adiponectin an decreased leptin levels after 120 days in the fish oil group, reinforce the importance of evaluating prospective studies of fish and fish oil fish ingestion on these adipokines in an attempt to decrease cardiovascular risk factors in patients with SLE.
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. marcell_lozovoy@hotmail.com.
authors.forename: Marcell Alysson Batisti
authors.initials: MA
authors.lastname: Lozovoy
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. deianame@yahoo.com.br.
authors.forename: Andréa Name Colado
authors.initials: AN
authors.lastname: Simão
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. helena@sercomtel.com.br.
authors.forename: Helena Kaminami
authors.initials: HK
authors.lastname: Morimoto
authors.affiliation: Post Graduate Program in Health Sciences, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. b_miglioranza@yahoo.com.br.
authors.forename: Bruna Miglioranza
authors.initials: BM
authors.lastname: Scavuzzi
authors.affiliation: Post Graduate Program in Pathology, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. tati_mvi@yahoo.com.br.
authors.forename: Tathiana Veiga Mayumi
authors.initials: TV
authors.lastname: Iriyoda
authors.affiliation: Department of Pathology, Clinical Analysis and Toxicology, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. reiche@sercomtel.com.br.
authors.forename: Edna Maria Vissoci
authors.initials: EM
authors.lastname: Reiche
authors.affiliation: Laboratory of Pathophysiology of Free Radicals, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. cecchini@uel.br.
authors.forename: Rubens
authors.initials: R
authors.lastname: Cecchini
authors.affiliation: Department of Internal Medicine, Rua Robert Koch, University of Londrina, Londrina, Paraná 86038-440, Brazil. dichi@sercomtel.com.br.
authors.forename: Isaias
authors.initials: I
authors.lastname: Dichi
mesh_terms: D052242:Adiponectin / Q000819:agonists / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D020738:Leptin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D020738:Leptin