title: β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise significantly reduce abdominal adiposity in healthy elderly men.
abstract: The effects of 12-weeks of HMB ingestion and resistance training (RT) on abdominal adiposity were examined in 48 men (66-78 yrs). All participants were randomly assigned to 1 of 4 groups: no-training placebo (NT-PL), HMB only (NT-HMB), RT with PL (RT-PL), or HMB with RT (RT-HMB). DXA was used to estimate abdominal fat mass (AFM) by placing the region of interest over the L1-L4 region of the spine. Outcomes were assessed by ANCOVA, with Bonferroni-corrected pairwise comparisons. Baseline AFM values were used as the covariate. The ANCOVA indicated a significant difference (p = 0.013) between group means for the adjusted posttest AFM values (mean (kg) ± SE: NT-PL = 2.59 ± 0.06; NT-HMB = 2.59 ± 0.61; RT-PL = 2.59 ± 0.62; RT-HMB = 2.34 ± 0.61). The pairwise comparisons indicated that AFM following the intervention period in the RT-HMB group was significantly less than NT-PL (p = 0.013), NT-HMB (p = 0.011), and RT-PL (p = 0.010). These data suggested that HMB in combination with 12 weeks of RT decreased AFM in elderly men.
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States. Electronic address: Jeffrey.Stout@ucf.edu.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stout
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States.
authors.forename: David H
authors.initials: DH
authors.lastname: Fukuda
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States.
authors.forename: Kristina L
authors.initials: KL
authors.lastname: Kendall
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States.
authors.forename: Abbie E
authors.initials: AE
authors.lastname: Smith-Ryan
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States.
authors.forename: Jordan R
authors.initials: JR
authors.lastname: Moon
authors.affiliation: Institute of Exercise Physiology and Wellness, University of Central Florida, Orlando, FL, United States.
authors.forename: Jay R
authors.initials: JR
authors.lastname: Hoffman
mesh_terms: D050153:Abdominal Fat; D050154:Adiposity / Q000187:drug effects*; D000368:Aged; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D055070:Resistance Training; D014631:Valerates / Q000494:pharmacology*
chemical_list: D014631:Valerates; C004961:beta-hydroxyisovaleric acid
keywords: Abdominal fat mass; Aging; Exercise; β-Hydroxy-β-methylbutyrate