title: Multidisciplinary approach to follicular thyroid carcinoma with giant mandibular and multiple sites metastases Case report.
abstract: Multidisciplinary approach to follicular thyroid carcinoma with giant mandibular and multiple sites metastases. Case report Metastatic tumors generally have poor prognosis, with short survival period and rarely indication to surgical treatment. In case of thyroid-differentiated cancer with distant metastases, prognosis is usually better, because of the possibility of treating metastasis by Radio Ablation by 131Iodine, after surgery. We report the case of a 65 years old woman, presenting with a giant mandibular metastasis from follicular thyroid carcinoma, originating from a cervico-mediastinal nonfunctioning goiter, with lung metastases. After the diagnostic work-up, she underwent left hemi-mandibulectomy, reconstruction by the placement of a precustomized titanium plate with condylar prosthesis and total thyroidectomy. Subsequently the Patient was treated by Radio Ablation by 131 Iodine, in four consecutive sessions. She is alive with no progression of the neoplasm after forty-six months follow-up. Even in advanced differentiated thyroid carcinoma, surgery should be taken into consideration, to treat the patient by complementary therapies and to improve the prognosis in term of survival.
  
  
  BACKGROUND
  Advanced differentiated thyroid carcinoma, Metastatic differentiated thyroid carcinoma.
authors.forename: Loredana
authors.initials: L
authors.lastname: De Pasquale
authors.forename: Dimitri
authors.initials: D
authors.lastname: Rabbiosi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bardazzi
authors.forename: Luca
authors.initials: L
authors.lastname: Autelitano
authors.forename: Giacomina Pierina
authors.initials: GP
authors.lastname: Moro
authors.forename: Giorgio
authors.initials: G
authors.lastname: Ghilardi
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D033183:Interdisciplinary Communication; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008339:Mandibular Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D009378:Neoplasms, Multiple Primary; D019651:Plastic Surgery Procedures; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods; D016896:Treatment Outcome