title: Gastric myeloid sarcoma without acute myeloblastic leukemia.
abstract: Myeloid sarcomas (MS) involve extramedullary blast proliferation from one or more myeloid lineages that replace the original tissue architecture, and these neoplasias are called granulocytic sarcomas, chloromas or extramedullary myeloid tumors. Such tumors develop in lymphoid organs, bones (e.g., skulls and orbits), skin, soft tissue, various mucosae, organs, and the central nervous system. Gastrointestinal (GI) involvement is rare, while the occurrence of myeloid sarcomas in patients without leukemia is even rare. Here, we report a case of a 38-year-old man who presented with epigastric pain and progressive jaundice. An upper GI endoscopy had shown extensive multifocal hyperemic fold thickening and the spread of nodular lesions in the body of the stomach. Biopsies from the gastric lesions indicated myeloid sarcoma of the stomach. However, concurrent peripheral blood and bone marrow examinations showed no evidence of acute myeloid leukemia. For diagnosis, the immunohistochemical markers must be checked when evaluating a suspected myeloid sarcoma case. Accurate MS diagnosis determines the appropriate therapy and prognosis.
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Huang
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Tao
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Li
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Chen
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Chun-Kui
authors.initials: CK
authors.lastname: Shao
authors.affiliation: Xiao-Li Huang, Jin Tao, Jian-Zhong Li, Xiao-Liang Chen, Bin Wu, Department of Gastroenterology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001856:Bone Marrow Examination; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D023981:Sarcoma, Myeloid / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Abdominal pain; Acute myeloblastic leukemia; Immunohistochemistry; Myeloid sarcoma; Stomach