title: Poly(ethylene glycol) Corona Chain Length Controls End-Group-Dependent Cell Interactions of Dendron Micelles.
abstract: To systematically investigate the relationship among surface charge, PEG chain length, and nano-bio interactions of dendron-based micelles (DMs), a series of PEGylated DMs with various end groups (-NH2, -Ac, and -COOH) and PEG chain lengths (600 and 2000 g/mol) are prepared and testedin vitro. The DMs with longer PEG chains (DM2K) do not interact with cells despite their positively charged surfaces. In sharp contrast, the DMs with shorter PEG chains (DM600) exhibit charge-dependent cellular interactions, as observed in bothin vitroand molecular dynamics (MD) simulation results. Furthermore, all DMs with different charges display enhanced stability for hydrophobic dye encapsulation compared to conventional linear-block copolymer-based micelles, by allowing only a minimal leakage of the dyein vitro. Our results demonstrate the critical roles of the PEG chain length and polymeric architecture on the terminal charge effect and the stability of micelles, which provides an important design cue for polymeric micelles.
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Hao-Jui
authors.initials: HJ
authors.lastname: Hsu
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Soumyo
authors.initials: S
authors.lastname: Sen
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Pearson
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Sayam
authors.initials: S
authors.lastname: Uddin
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Petr
authors.initials: P
authors.lastname: Král
authors.affiliation: Departments of Biopharmaceutical Sciences, Bioengineering, Chemistry, and Physics, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
authors.forename: Seungpyo
authors.initials: S
authors.lastname: Hong