title: An Eighteen-Month Helicobacter Infection Does Not Induce Amyloid  Plaques or Neuroinflammation in Brains of Wild Type C57BL/6J Mice.
abstract: There is increasing evidence to support the role of infectious agents in the progression of Alzheimer's disease (AD), especially Helicobacter pylori (H. pylori). The impact of Helicobacter infection on the brain of non-AD predisposed mice was studied. For that, C57BL/6J mice were infected by oral gavage with H. pylori SS1 (n = 6) and Helicobacter felis (H. felis) (n=6) or not infected (n = 6) for evaluation of neuroinflammation (anti-GFAP and anti-iba1 immunohistochemistry) and amyloid-β deposition (thioflavin-S stain and anti-Aβ immunohistochemistry). After 18-month of infection, H. pylori SS1 and H. felis infection induced a strong gastric inflammation compared to non-infected mice, but did not induce brain neuroinflammation or amyloid-β deposition.
authors.forename: Claire Roubaud
authors.initials: CR
authors.lastname: Baudron
authors.forename: Lucie
authors.initials: L
authors.lastname: Chambonnier
authors.forename: Alice
authors.initials: A
authors.lastname: Buissionnière
authors.forename: Alban
authors.initials: A
authors.lastname: Giese
authors.forename: Nathalie
authors.initials: N
authors.lastname: Macrez
authors.forename: Yoon
authors.initials: Y
authors.lastname: Cho
authors.forename: Valérie
authors.initials: V
authors.lastname: Fénelon
authors.forename: Lucie
authors.initials: L
authors.lastname: Blaszczyk
authors.forename: Pierre
authors.initials: P
authors.lastname: Dubus
authors.forename: Philippe
authors.initials: P
authors.lastname: Lehours
authors.forename: Francis
authors.initials: F
authors.lastname: Mégraud
authors.forename: Nathalie
authors.initials: N
authors.lastname: Salles
authors.forename: Christine
authors.initials: C
authors.lastname: Varon
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D016481:Helicobacter Infections / Q000276:immunology* / Q000473:pathology*; D044922:Helicobacter felis; D016480:Helicobacter pylori; D008810:Mice, Inbred C57BL; D015213:Neuroimmunomodulation; D058225:Plaque, Amyloid / Q000276:immunology / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides