title: Efficacy and safety of long-term tolvaptan treatment in a patient with SCLC and SIADH.
abstract: Hyponatremia frequently occurs in patients with cancer and is mostly due to a syndrome of inappropriate antidiuresis caused by ectopic secretion of antidiuretic hormone (SIADH). Small cell lung cancer presents with SIADH in approximately 11%-15% of cases. Recently, a new class of drugs, vasopressin V2-receptor antagonists (vaptans), emerged as a promising treatment for SIADH, but efficacy and safety data in cancer patients are lacking. We present a case of SIADH, heralding small cell lung cancer and persisting after apparent complete remission of primary tumor following chemotherapy/radiotherapy, in a patient who underwent long-term treatment with tolvaptan without any serious adverse effects.
authors.affiliation: 1 Medical Oncology Unit, University Hospital of Parma, Parma - Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Bordi
authors.forename: Marcello
authors.initials: M
authors.lastname: Tiseo
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Buti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Regolisti
authors.forename: Andrea
authors.initials: A
authors.lastname: Ardizzoni
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001552:Benzazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000188:drug therapy / Q000209:etiology* / Q000517:prevention & control*; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000209:etiology; D008175:Lung Neoplasms / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D008875:Middle Aged; D012074:Remission Induction; D055752:Small Cell Lung Carcinoma / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D000077602:Tolvaptan; D016896:Treatment Outcome
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D000077602:Tolvaptan