title: Mitochondrial division and fusion in metabolism.
abstract: Mitochondria govern many metabolic processes. In addition, mitochondria sense the status of metabolism and change their functions to regulate energy production, cell death, and thermogenesis. Recent studies have revealed that mitochondrial structural remodeling through division and fusion is critical to the organelle's function. It has also become clear that abnormalities in mitochondrial division and fusion are linked to the pathophysiology of metabolic diseases such as diabetes and obesity. Here, we discuss the current understanding of the mechanisms of mitochondrial dynamics and their role in cellular and organismal metabolism.
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
authors.forename: Madhuparna
authors.initials: M
authors.lastname: Roy
authors.affiliation: Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, TX, United States.
authors.forename: P Hemachandra
authors.initials: PH
authors.lastname: Reddy
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
authors.forename: Miho
authors.initials: M
authors.lastname: Iijima
authors.affiliation: Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address: hsesaki@jhmi.edu.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sesaki
mesh_terms: D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008660:Metabolism; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D009765:Obesity / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology