title: Comparative analysis of cardiovascular effects of selenium nanoparticles and sodium selenite in zebrafish embryos.
abstract: Selenium acts as an important element in the prevention and treatment of cardiovascular diseases but their health-related effects have not been fully explored. As a novel attempt, zebrafish embryos were treated separately with SeNPs (5-25 μg/ml) and sodium selenite (5-25 μg/ml) starting at early blastula stage. Abnormalities were also observed in the morphology of the zebrafish embryos. The SeNPs-treated embryos exhibited concentration-dependent increased in mortality, pericardial edema, and cardiac arrhythmia. In contrast, sodium selenite showed no significant malformation effect in developing zebrafish embryos. The results of the present study conclude that the SeNPs were more toxic than sodium selenite. The results also suggest that lower concentrations of SeNPs and sodium selenite can be used as possible therapeutic agents for cardiovascular-related problems.
authors.affiliation: a Department of Biotechnology , Kalasalingam University , Krishnankoil , Tamilnadu , India.
authors.forename: Kalimuthu
authors.initials: K
authors.lastname: Kalishwaralal
authors.affiliation: a Department of Biotechnology , Kalasalingam University , Krishnankoil , Tamilnadu , India.
authors.forename: Subhaschandrabose
authors.initials: S
authors.lastname: Jeyabharathi
authors.affiliation: a Department of Biotechnology , Kalasalingam University , Krishnankoil , Tamilnadu , India.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Sundar
authors.affiliation: a Department of Biotechnology , Kalasalingam University , Krishnankoil , Tamilnadu , India.
authors.forename: Azhaguchamy
authors.initials: A
authors.lastname: Muthukumaran
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000196:embryology / Q000473:pathology; D036703:Blastula / Q000196:embryology*; D004305:Dose-Response Relationship, Drug; D053758:Nanoparticles / Q000633:toxicity*; D010490:Pericardial Effusion / Q000139:chemically induced / Q000196:embryology / Q000473:pathology; D012643:Selenium / Q000633:toxicity*; D018038:Sodium Selenite / Q000633:toxicity*; D015027:Zebrafish / Q000196:embryology*
chemical_list: D012643:Selenium; D018038:Sodium Selenite
keywords: cardiac arrhythmia; cardiovascular; pericardial edema; selenium nanoparticles; sodium selenite; zebrafish embryos