title: Total synthesis of Herbarin A and B, determination of their antioxidant properties and toxicity in zebrafish embryo model.
abstract: Herbarin A and B were isolated from the fungal strains of Cladosporium herbarum found in marine sponges Aplysina aerophoba and Callyspongia aerizusa. Total synthesis of Herbarin A and B was achieved by carrying out a multi-step synthesis approach, and the antioxidant properties were evaluated using FRAP assay. Toxicity of these compounds was determined using a zebrafish embryo model.
authors.affiliation: Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Heimberger
authors.affiliation: Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA.
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Cade
authors.affiliation: Department of Biology, Georgia Southern University, 1332 Southern Drive, Statesboro, GA 30460-8042, USA.
authors.forename: Jihan
authors.initials: J
authors.lastname: Padgett
authors.affiliation: Department of Biology, Georgia Southern University, 1332 Southern Drive, Statesboro, GA 30460-8042, USA.
authors.forename: Vinoth
authors.initials: V
authors.lastname: Sittaramane
authors.affiliation: Department of Chemistry, Georgia Southern University, 521 College of Education Drive, Statesboro, GA 30460-8064, USA. Electronic address: malnu@georgiasouthern.edu.
authors.forename: Abid
authors.initials: A
authors.lastname: Shaikh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002963:Cladosporium / Q000737:chemistry / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D023421:Models, Animal; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D015027:Zebrafish / Q000254:growth & development
chemical_list: D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D011753:Pyrones; C000603765:herbarin A
keywords: Antioxidant properties; Natural products; Total synthesis; Toxicity; Zebrafish