title: The use of automated system for EEG analysis and feedback cerebral stimulation to stop epileptiform activity in WAG/Rij rats.
abstract: Original software program is described, which revealed EEG activity characteristic of the onset of epileptic seizure and turned on electrical stimulation of the nucleus basalis of Meynert in WAG/Rij rats with congenital absence epilepsy. The program reliably detected the onset of seizure and automatically stopped it with a high-frequency train of electrical impulses (100-150 Hz). Thus, a feedback system of deep brain stimulation has been developed to stop early manifestations of absence epileptiform seizures. The study can be a base to develop an implanted apparatus to automatically analyze EEG and stimulate the brain to stop the epileptic seizures.
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia, vitaliyablik@gmail.com.
authors.forename: V A
authors.initials: VA
authors.lastname: Blik
authors.forename: A V
authors.initials: AV
authors.lastname: Aristov
authors.forename: N E
authors.initials: NE
authors.lastname: Chepurnova
mesh_terms: D000818:Animals; D066272:Basolateral Nuclear Complex / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000295:instrumentation / Q000379:methods*; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000517:prevention & control*; D025461:Feedback, Physiological / Q000502:physiology*; D051381:Rats; D012984:Software