title: Brain natriuretic peptide: the reason of respiratory distress is heart disease or lung disease?
abstract: OBJECTIVE
  The aim of this study was to determine whether plasma levels of amino-terminal brain natriuretic peptide (BNP) could differentiate between heart failure and lung disease among infants with acute bronchiolitis.
  
  
  METHODS
  Sixty-eight infants (age range, 1-26 months; median age, 5.9 ± 5.0 months) who presented with respiratory distress underwent physical examination, plasma BNP measurement, and echocardiography within 24 hours after admission. Nineteen (28%) patients had congenital heart disease. The control group was consisted of 30 healthy infants.
  
  
  RESULTS
  Although mean plasma BNP levels were 118.9 ± 219.5 pg/mL in patients with isolated bronchiolitis (n = 49), it was 841.2 ± 1475.8 pg/mL in patients with congenital heart disease (n = 19). Plasma BNP levels were significantly higher in infants with congenital heart disease (P = .001).
  
  
  CONCLUSIONS
  It was shown that plasma BNP levels were affected much more in cardiac disease rather than lung disease. Among infants with respiratory distress, plasma BNP measurements can differentiate congenital heart disease and lung disease and can be used to monitor the effects of treatment for infants with heart failure.
  The comments were taken for consideration. The patient groups control BNP levels were attached to the results. As it was a clinical study and multiple factors (respiratory score, respiratory rate, treatment, etc) may effect on BNP levels, the tables could not be decreased to 1 table.
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey.
authors.forename: Taylan
authors.initials: T
authors.lastname: Sahingozlu
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey. Electronic address: ulas_karadas78@mynet.com.
authors.forename: Ulaş
authors.initials: U
authors.lastname: Karadas
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey.
authors.forename: Kayi
authors.initials: K
authors.lastname: Eliacik
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey.
authors.forename: Ali Rahmi
authors.initials: AR
authors.lastname: Bakiler
authors.affiliation: Ege University Pediatrics, İzmir, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Ozdemir Karadas
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey.
authors.forename: Muhammed Ali
authors.initials: MA
authors.lastname: Kanik
authors.affiliation: İzmir Tepecik Resarch Hospital, İzmir, Turkey.
authors.forename: Masaallah
authors.initials: M
authors.lastname: Baran
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D001988:Bronchiolitis / Q000097:blood* / Q000150:complications*; D016022:Case-Control Studies; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood* / Q000150:complications*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010100:Oxygen / Q000097:blood; D012131:Respiratory Insufficiency / Q000097:blood* / Q000209:etiology*; D056152:Respiratory Rate
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D010100:Oxygen