title: Radiofrequency-triggered tumor-targeting delivery system for theranostics application.
abstract: In this study, a new type of magnetic tumor-targeting PEGylated gold nanoshell drug delivery system (DOX-TSMLs-AuNSs-PEG) based on doxorubicin-loaded thermosensitive magnetoliposomes was successfully obtained. The reverse-phase evaporation method was used to construct the magnetoliposomes, and then gold nanoshells were coated on the surface of it. The DOX-TSMLs-AuNSs-PEG delivery system was synthesized after SH-PEG2000 modification. This multifunction system was combined with a variety of functions, such as radiofrequency-triggered release, chemo-hyperthermia therapy, and dual-mode magnetic resonance/X-ray imaging. Importantly, the DOX-TSMLs-AuNSs-PEG complex was found to escape from endosomes after cellular uptake by radiofrequency-induced endosome disruption before lysosomal degradation. All results in vitro and in vivo indicated that DOX-TSMLs-AuNSs-PEG is a promising effective drug delivery system for diagnosis and treatment of tumors.
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Panpan
authors.initials: P
authors.lastname: Zhang
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Shi
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Hao
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Dehui
authors.initials: D
authors.lastname: Meng
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Yalin
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yanyan
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang
authors.affiliation: †School of Chemistry and Molecular Engineering, ‡School of Pharmaceutical Sciences, and §School of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000528:radiation effects; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000528:radiation effects; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011846:Radio Waves; D011859:Radiography
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D006046:Gold; D004317:Doxorubicin
keywords: chemo-hyperthermia therapy; controlled release; dual-mode MR/X-ray imaging; gold nanoshells; thermosensitive magnetoliposomes