title: Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin.
abstract: Hepatitis E virus genotype-3 (HEV3) infection can cause chronic hepatitis in immunosuppressed patients and induce extra-hepatic manifestations, such as neurological symptoms, kidney injuries, and immune-mediated thrombocytopenia. Very few cases of HEV-induced kidney manifestations have been reported. Herein, we report, for the first time, a case of de novo membranoproliferative glomerulonephritis that occurred in a kidney transplant patient who developed a chronic HEV3 infection, which was successfully treated with ribavirin.
authors.affiliation: Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France; Université Paul Sabatier, Toulouse, France.
authors.forename: A
authors.initials: A
authors.lastname: Del Bello
authors.forename: C
authors.initials: C
authors.lastname: Guilbeau-Frugier
authors.forename: A-G
authors.initials: AG
authors.lastname: Josse
authors.forename: L
authors.initials: L
authors.lastname: Rostaing
authors.forename: J
authors.initials: J
authors.lastname: Izopet
authors.forename: N
authors.initials: N
authors.lastname: Kamar
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D003449:Cryoglobulinemia / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D006084:Graft Rejection / Q000517:prevention & control*; D016751:Hepatitis E / Q000188:drug therapy*; D016752:Hepatitis E virus; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009394:Nephritis, Hereditary / Q000601:surgery; D012254:Ribavirin / Q000627:therapeutic use*; D066027:Transplant Recipients; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D012254:Ribavirin
keywords: de novo glomerulopathy; hepatitis E virus; kidney transplantation; membranoproliferative glomerulonephritis; ribavirin