title: Organocatalytic enantioselective Friedel-Crafts reaction: an efficient access to chiral isoindolo-β-carboline derivatives.
abstract: An organocatalytic asymmetric Friedel-Crafts reaction between indole and indole-derived hydroxylactams has been realized to furnish isoindolo-β-carbolines in good to excellent yields (up to >99%) and generally high enantioselectivities (up to >99% ee). The methodology offers an efficient access to functionalization of isoindolo-β-carbolines and preparation of chiral isoindolo-β-carboline derivatives.
authors.affiliation: Department of Chemistry, South University of Science and Technology of China, Shenzhen, 518055, P. R. China. lipf@sustc.edu.cn.
authors.forename: Fang
authors.initials: F
authors.lastname: Fang
authors.forename: Genghong
authors.initials: G
authors.lastname: Hua
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
mesh_terms: D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D002243:Carbolines; D007211:Indoles; D054833:Isoindoles; D007769:Lactams; C030374:indole