title: PARK2/Parkin becomes critical when DNM1L/Drp1 is absent.
abstract: Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.
authors.affiliation: a Department of Cell Biology ; Johns Hopkins University School of Medicine ; Baltimore , MD USA.
authors.forename: Madhuparna
authors.initials: M
authors.lastname: Roy
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kageyama
authors.forename: Miho
authors.initials: M
authors.lastname: Iijima
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sesaki
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D034281:Dynamins / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism; D063306:Mitophagy; D009206:Myocardium / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; C486391:Dnm1l protein, mouse; D034281:Dynamins
keywords: Drp1; Parkin; mitochondrial dynamics; mitochondrial homeostasis; mitophagy