title: The role of antibody in enhancing dengue virus infection.
abstract: Dengue virus has four distinct serotypes whose cross-reactive immune responses contribute to increased disease severity following heterologous infections. It was proposed that non-protective cross-reactive antibodies may play a role in disease enhancement. In this study we develop a mathematical model of host-virus interaction and predict the mechanisms responsible for virus expansion and loss during primary and secondary dengue infections. We use the model to determine the role of cross-reactive antibodies during dengue fever and dengue hemorrhagic fever-inducing secondary infections, and then compare the model to published patient data. We predict that the cross-reactive antibodies interfere with the non-neutralizing antibody effects by reducing the phagocyte-mediated removal of antibody-virus immune complexes.
authors.affiliation: Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Nikin-Beers
authors.affiliation: Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA. Electronic address: stanca@math.vt.edu.
authors.forename: Stanca M
authors.initials: SM
authors.lastname: Ciupe
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology*; D060085:Coinfection / Q000635:transmission*; D003715:Dengue / Q000276:immunology* / Q000635:transmission*; D003716:Dengue Virus / Q000472:pathogenicity*; D006801:Humans; D008962:Models, Theoretical
chemical_list: D000914:Antibodies, Viral
keywords: Antibody-dependent enhancement; Dengue fever; Dengue hemorrhagic fever; Dengue virus; Mathematical modeling