title: Valsalva-Like Retinopathy Secondary to Pancytopenia following Induction of Etoposide and Ifosfamide.
abstract: Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies. Ocular side effects are rarely reported. We describe a case of a patient on etoposide and ifosfamide who presented with unilateral vision loss, anemia, and thrombocytopenia. The patient was found to have a large subinternal limiting membrane hemorrhage in the right eye that is thought to be related to his anemia and thrombocytopenia. The hemorrhage resolved spontaneously after 10 days. This case illustrates how bone marrow suppression by chemotherapeutic agents may indirectly contribute to retinal hemorrhages resulting in at least transient vision loss.
authors.affiliation: Department of Ophthalmology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Prinzi
authors.affiliation: Department of Ophthalmology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Saraf
authors.affiliation: Department of Ophthalmology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Ankit
authors.initials: A
authors.lastname: Desai
authors.affiliation: Vanderbilt Eye Institute, 2311 Pierce Avenue, Nashville, TN 37232, USA.
authors.forename: Oscar
authors.initials: O
authors.lastname: Kuruvilla
authors.affiliation: Department of Ophthalmology, Henry Ford Hospital, 2799 W. Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Uday R
authors.initials: UR
authors.lastname: Desai