title: Prospective randomized comparison of scar appearances between cograft of acellular dermal matrix with autologous split-thickness skin and autologous split-thickness skin graft alone for full-thickness skin defects of the extremities.
abstract: BACKGROUND
  The purpose of this study was to evaluate the clinical outcomes of cografting of acellular dermal matrix with autologous split-thickness skin and autologous split-thickness skin graft alone for full-thickness skin defects on the extremities.
  
  
  METHODS
  In this prospective randomized study, 19 consecutive patients with full-thickness skin defects on the extremities following trauma underwent grafting using either cograft of acellular dermal matrix with autologous split-thickness skin graft (nine patients, group A) or autologous split-thickness skin graft alone (10 patients, group B) from June of 2011 to December of 2012. The postoperative evaluations included observation of complications (including graft necrosis, graft detachment, or seroma formation) and Vancouver Scar Scale score.
  
  
  RESULTS
  No statistically significant difference was found regarding complications, including graft necrosis, graft detachment, or seroma formation. At week 8, significantly lower Vancouver Scar Scale scores for vascularity, pliability, height, and total score were found in group A compared with group B. At week 12, lower scores for pliability and height and total scores were identified in group A compared with group B.
  
  
  CONCLUSIONS
  For cases with traumatic full-thickness skin defects on the extremities, a statistically significant better result was achieved with cograft of acellular dermal matrix with autologous split-thickness skin graft than with autologous split-thickness skin graft alone in terms of Vancouver Scar Scale score.
  
  
  METHODS
  Therapeutic, II.
authors.affiliation: Seongnam and Seoul, Republic of Korea From the Department of Orthopedic Surgery, Armed Forces Capital Hospital; and the Department of Orthopedic Surgery, Ewha Womans University School of Medicine.
authors.forename: Ju Won
authors.initials: JW
authors.lastname: Yi
authors.forename: Jae Kwang
authors.initials: JK
authors.lastname: Kim
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D005121:Extremities / Q000293:injuries; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012867:Skin / Q000293:injuries*; D016038:Skin Transplantation / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome