title: Indoor determinants of dustborne allergens in Mexican homes.
abstract: Exposure to indoor allergens represents a significant risk factor for allergies and asthma in several parts of the world. In Mexico, few studies have evaluated indoor allergens, including cat, dog, and mouse allergens and the factors that predict their presence. This study evaluates the main environmental and household predictors of high prenatal allergen levels and multiple allergen exposures in a birth cohort from Mexico City. A cross-sectional study was conducted as part of a birth cohort study of 1094 infants recruited during pregnancy and followed until delivery. We collected dust samples in a subset of 264 homes and assessed environmental factors. Der p 1, Der f 1, dust mite group 2, Fel d 1, Can f 1, Rat n 1, Mus m 1, and Bla g 2 concentrations in dust samples were measured using immunoassays. To define detectable allergen levels, the lowest limits of detection for each allergen were taken as cutoff points. Overall allergen exposure was considered high when four or more allergens exceeded detectable levels in the same household. Logistic regression was used for predictive models. Eighty-five percent of homes had at least one allergen in dust over the detection limit, 52.1% had high exposure (four or more allergens above detectable limits), and 11.7% of homes had detectable levels for more than eight allergens. Der p 1, Der p 2, Mus m 1, and Fel d 1 were the most frequent allergens detected. Each allergen had both common and distinct predictors. The main predictors of a high multiple allergen index were the size of the home, pesticide use, mother's age, mother as homemaker, and season. Increased indoor environmental allergen exposure is mainly related to sociodemographic factors and household cleaning.
authors.affiliation: Instituto Nacional de Salud Pública, Av. Universidad No. 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico.
authors.forename: Leticia
authors.initials: L
authors.lastname: Hernández-Cadena
authors.forename: Darryl C
authors.initials: DC
authors.lastname: Zeldin
authors.forename: Albino
authors.initials: A
authors.lastname: Barraza-Villarreal
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Sever
authors.forename: Peter D
authors.initials: PD
authors.lastname: Sly
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: London
authors.forename: María Consuelo
authors.initials: MC
authors.lastname: Escamilla-Nuñez
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
mesh_terms: D000293:Adolescent; D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D000818:Animals; D004391:Dust / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008800:Mexico; D010575:Pesticides / Q000009:adverse effects; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology; D012621:Seasons; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D000485:Allergens; D004391:Dust; D010575:Pesticides