title: Bile acid activated receptors are targets for regulation of integrity of gastrointestinal mucosa.
abstract: Bile acids are the end product of cholesterol metabolism. Synthesized in the liver, primary bile acids are secreted by hepatocytes and are transformed by intestinal microbiota into secondary bile acids. In addition to their role in cholesterol and lipid absorption, bile acids act as signaling molecules activating a family of nuclear and G-protein-coupled receptors collectively known as bile acid activated receptors (BARs). These receptors are expressed at high density in enterohepatic tissues, but their expression occurs throughout the body and their activation mediates regulatory functions of bile acids on lipids and glucose metabolism and immunity. In the gastrointestinal tract, BARs maintain intestinal integrity, and their deletion makes the intestine more susceptible to the damage caused by acetylsalicylic acid and nonsteroidal anti-inflammatory drugs (NSAIDs). Deficiency in farnesoid X receptor and G-protein-coupled bile acid receptor 1 genes alters the expression/activity of cystathione γ-lyase and endothelial nitric oxide synthase, two genes involved in the synthesis of hydrogen sulfide and nitric oxide, i.e., two gaseous mediators that have been shown to be essential in maintaining the intestinal homeostasis. In addition, farnesoid X receptor regulates the expression of transporters required for secretion of phospholipid by hepatocytes. Because phospholids attenuate intestinal injury caused by acetylsalicylic acid and NSAIDs, BAR agonism could be exploited to protect the intestinal mucosa against injury caused by anti-inflammatory medications. This approach might be useful in the prevention of so-called NSAID enteropathy, a common clinical condition occurring in long-term users of NSAIDs, which is not effectively prevented either by cotreatment with proton pump inhibitors or by the use of coxibs.
authors.affiliation: Azienda Ospedaliera di Perugia, Perugia, Italy.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Distrutti
authors.forename: Luca
authors.initials: L
authors.lastname: Santucci
authors.forename: Sabrina
authors.initials: S
authors.lastname: Cipriani
authors.forename: Barbara
authors.initials: B
authors.lastname: Renga
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Schiaroli
authors.forename: Patrizia
authors.initials: P
authors.lastname: Ricci
authors.forename: Annibale
authors.initials: A
authors.lastname: Donini
authors.forename: Stefano
authors.initials: S
authors.lastname: Fiorucci
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D050356:Lipid Metabolism; D015398:Signal Transduction
chemical_list: D001647:Bile Acids and Salts