title: Learning from PAINful lessons.
abstract: Chemical probes are important both as tools to understand biology and as starting points for drug leads, but not every active molecule makes a good probe; many react nonspecifically with thiols. These promiscuous inhibitors are worse than useless because they can mislead researchers and muddy the literature. Understanding the mechanisms of such compounds can prevent scientists from following false hits down blind alleys.
authors.affiliation: Carmot Therapeutics Inc. , 409 Illinois Street, San Francisco, California 94158, United States.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Erlanson
mesh_terms: D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D015335:Molecular Probes / Q000737:chemistry* / Q000494:pharmacology / Q000592:standards; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000592:standards; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology / Q000592:standards
chemical_list: D015335:Molecular Probes; D004364:Pharmaceutical Preparations; D054852:Small Molecule Libraries