title: General analytical procedure for determination of acidity parameters of weak acids and bases.
abstract: The paper presents a new convenient, inexpensive, and reagent-saving general methodology for the determination of pK a values for components of the mixture of diverse chemical classes weak organic acids and bases in water solution, without the need to separate individual analytes. The data obtained from simple pH-metric microtitrations are numerically processed into reliable pK a values for each component of the mixture. Excellent agreement has been obtained between the determined pK a values and the reference literature data for compounds studied.
authors.affiliation: Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland.
authors.forename: Bogusław
authors.initials: B
authors.lastname: Pilarski
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
authors.forename: Roman
authors.initials: R
authors.lastname: Kaliszan
authors.affiliation: Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Wyrzykowski
authors.affiliation: Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Młodzianowski
authors.affiliation: Cerko Sp. z o.o. Sp.K, Al. Zwycięstwa 96/98, 81-451 Gdynia, Poland ; Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
authors.forename: Agata
authors.initials: A
authors.lastname: Balińska