title: [Structural alterations during the course of glaucoma disease].
abstract: BACKGROUND
  Structural changes in the course of glaucoma disease affect the trabecular meshwork and ciliary body in addition to the optic disc as the primary site of glaucoma damage.
  
  
  OBJECTIVE
  Latest results from experimental studies, animal models and measurements in human eyes are presented and discussed.
  
  
  RESULTS
  The presenting scenario is complex with age, biochemical and mechanical stress factors leading to subsequent, irreversible tissue change in the trabecular meshwork and cribriform plate of the optic nerve, resulting in neuronal tissue loss.
  
  
  CONCLUSIONS
  Knowledge of these changes will be the key for future glaucoma therapies.
authors.affiliation: Universitätsaugenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland, Christian.Mardin@uk-erlangen.de.
authors.forename: C Y
authors.initials: CY
authors.lastname: Mardin
authors.forename: U
authors.initials: U
authors.lastname: Schlötzer-Schrehardt
mesh_terms: D002909:Chronobiology Phenomena; D002924:Ciliary Body / Q000473:pathology* / Q000503:physiopathology; D005901:Glaucoma / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008954:Models, Biological; D009898:Optic Disk / Q000473:pathology* / Q000503:physiopathology; D014129:Trabecular Meshwork / Q000473:pathology* / Q000503:physiopathology