title: New cytotoxic sesquiterpenoids from Siegesbeckia glabrescens.
abstract: Two new sesquiterpenoids, siegenolides A (1) and B (2), and two known sesquiterpenes 3 and 4 were isolated from Siegesbeckia glabrescens. Their structures were elucidated by spectroscopic analyses, and they were further evaluated for their cytotoxic activities against human cancer cells (MCF-7, AsPC-1, SW480, HCT 116, HepG2, HeLa). Compounds 1-4 showed differential cytotoxic effects on the target cancer cells with IC50 values in the range of 0.9-33.3 μM.
authors.affiliation: Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. wuqiansy@hotmail.com.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. cooldog227@hotmail.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. miyuu_chan@naver.com.
authors.forename: So Yoon
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Natural Medicine Resources, Semyung University, Chungbuk 390-711, Korea. hwalee@semyung.ac.kr.
authors.forename: Hwa Jin
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. ryuha@sookmyung.ac.kr.
authors.forename: Jae-Ha
authors.initials: JH
authors.lastname: Ryu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045325:HCT116 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes