title: [Current Topics on Vitamin D. Evolution of animals and vitamin D].
abstract: Vitamin D3 is already found in the early evolution of life, but essentially as inactive products of the photochemical reaction of 7-dehydrocholesterol. The full vitamin D endocrine system characterized by the specific vitamin D transport protein (DBP) , specific vitamin D-metabolizing CYP P450 enzymes, active vitamin D metabolites, 1α,25 (OH) 2D3, specific vitamin D nuclear receptor (VDR), and fibroblast growth factor 23 (FGF23) became essential for maintaining calcium and bone homeostasis in terrestrial animals cope with the challenging of higher gravity and calcium-poor environment. The present review describes the story about the evolution of animals and vitamin D.
authors.affiliation: Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Suda
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001842:Bone and Bones / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D018167:Receptors, Calcitriol / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D018167:Receptors, Calcitriol; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23