title: The one year effects of three doses of hepatitis B vaccine as a booster in anti-HBs-negative children 11-15 years after primary immunization; China, 2009-2011.
abstract: The aim of this study was to evaluate hepatitis B surface antibody (anti-HBs) levels one year after hepatitis B booster vaccination in anti-HBs-negative (<10 mIU/mL) children 11-15 y after primary vaccination. Anti-HBs titers were examined in 235 children who were negative for hepatitis B surface antigen (HBsAg), anti-HBs, and hepatitis B core antibody (anti-HBc). The children were then divided into 3 groups based on their anti-HBs levels pre-booster: Group I, <0 .1 mIU/mL; Group II, 0.1 to <1 .0 mIU/mL; and Group III, 1.0 to <10 .0 mIU/mL. They were vaccinated with 3 doses of hepatitis B vaccine (0-1-6 month, 20 ug), and anti-HBs levels were measured. One month after the first dose, the anti-HBs positive rates (≥ 10 mIU/mL) in Groups I-III were 56.14%, 83.61% and 100%. One month after the third dose, the anti-HBs-positive rates in Groups I-III were 96.49%, 98.36% and 100%. One year after the third dose, the anti-HBs-positive rates in Groups I-III were 73.68%, 75.41% and 98.29%, respectively. Protective levels declined more rapidly for those with lower titers. Children with pre-booster anti-HBs titers of 1-9.9 mIU/mL might not need any booster dose, and the children with pre-booster titers of 0.1-0.9 and <0 .1 mIU/mL might need more than one dose booster vaccination.
authors.affiliation: a Zhejiang Provincial Center for Disease Control and Prevention ; Hangzhou , Zhejiang , China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Huan
authors.initials: H
authors.lastname: Shan
authors.forename: Yongdi
authors.initials: Y
authors.lastname: Chen
authors.forename: Zheng-gang
authors.initials: ZG
authors.lastname: Jiang
authors.forename: Xue-wei
authors.initials: XW
authors.lastname: Dai
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Ren
authors.forename: Kai-jin
authors.initials: KJ
authors.lastname: Xu
authors.forename: Bing
authors.initials: B
authors.lastname: Ruan
authors.forename: Shi-gui
authors.initials: SG
authors.lastname: Yang
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D008297:Male; D016896:Treatment Outcome
chemical_list: D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines
keywords: Chinese hamster ovary (CHO); booster vaccination; effect; hepatitis B surface antibody (anti-HBs); hepatitis B virus (HBV); one year