title: Coronary artery disease in primary biliary cirrhosis: A systematic review and meta-analysis of observational studies.
abstract: OBJECTIVE
  To investigate the association between primary biliary cirrhosis (PBC) and risk of coronary artery disease (CAD).
  
  
  METHODS
  We conducted a systematic review and meta-analysis of published observational studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratios with 95% confidence intervals (CI) comparing CAD risk in patients with PBC versus non-PBC controls. Pooled risk ratios and 95% confidence intervals were combined using a random-effect model and generic inverse variance of DerSimonian and Laird methods.
  
  
  RESULTS
  Four studies with 3362 patients with PBC were identified and included in our data analysis. The pooled risk ratio of CAD in patients with PBC was 1.57 (95% CI, 1.21-2.06). The statistical heterogeneity was low with an I(2) of 38%.
  
  
  CONCLUSIONS
  Our study demonstrated a statistically significant increased risk of CAD among patients with PBC.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.|Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Cardiac Electrophysiology Unit, Department of Physiology, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Wasin
authors.initials: W
authors.lastname: Ahuja
authors.affiliation: Department of Internal Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
authors.forename: Ittikorn
authors.initials: I
authors.lastname: Spanuchart
authors.affiliation: Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
keywords: coronary artery disease; epidemiology; meta-analysis; primary biliary cirrhosis