title: DNA-functionalized Pt nanoparticles as catalysts for chemically powered micromotors: toward signal-on motion-based DNA biosensor.
abstract: We present here the construction of a DNA biosensor based on a tubular micromotor that only produces motion-based signal in the presence of DNA target. This "turn on" characteristic of the sensor is achieved by the addition of Pt nanoparticle-DNA conjugate as the motion-inducing catalyst for the micromotors through DNA hybridization. Our work potentially offers new design strategies for motion-based biosensors with higher specificity.
authors.affiliation: Departments of Chemistry and Materials Science and Engineering, 315 S 1400 E Room 2020, Salt Lake City, UT 84112, USA. minteer@chem.utah.edu.
authors.forename: Khiem
authors.initials: K
authors.lastname: Van Nguyen
authors.forename: Shelley D
authors.initials: SD
authors.lastname: Minteer
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*
chemical_list: D010984:Platinum; D004247:DNA