title: Effects of iriflophenone 3-C-β-glucoside on fasting blood glucose level and glucose uptake.
abstract: BACKGROUND
  One of the biological activities of agar wood (Aquilaria sinensis Lour., Thymelaeaceae), is anti-hyperglycemic activity. The methanolic extract (ME) was proven to possess the fasting blood glucose activity in rat and glucose uptake transportation by rat adipocytes.
  
  
  OBJECTIVE
  To determine the decreasing fasting blood glucose level of constituents affordable for in vivo test. If the test was positive, the mechanism which is positive to the ME, glucose transportation, will be performed.
  
  
  METHODS
  The ME was separated by column chromatography and identified by spectroscopic methods. Mice was used as an animal model (in vivo), and rat adipocytes were used for the glucose transportation activity (in vitro).
  
  
  RESULTS
  Iriflophenone 3-C-β-glucoside (IPG) was the main constituent, 3.17%, and tested for the activities. Insulin and the ME were used as positive controls. The ME, IPG and insulin lowered blood glucose levels by 40.3, 46.4 and 41.5%, respectively, and enhanced glucose uptake by 152, 153, and 183%, respectively.
  
  
  CONCLUSIONS
  These findings suggest that IPG is active in lowering fasting blood glucose with potency comparable to that of insulin.
authors.affiliation: Faculty of Natural Resources, Rajamangala University of Technology ISAN Sakon Nakhon Campus, Muang, Thailand.
authors.forename: Ratree
authors.initials: R
authors.lastname: Pranakhon
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Muang, Thailand.
authors.forename: Chantana
authors.initials: C
authors.lastname: Aromdee
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Mueang, Khon Kaen, 40002 Thailand.
authors.forename: Patchareewan
authors.initials: P
authors.lastname: Pannangpetch
keywords: Aquilaria sinensis; glucose uptake activity; iriflophenone 3-C-β-glucoside; lowering fasting blood glucose; rat adipocytes