title: Predictive value of single photon emission computerized tomography and computerized tomography in osteonecrosis after femoral neck fracture: a prospective study.
abstract: OBJECTIVE
  Osteonecrosis of the femoral head (ONFH) is a very common complication after femoral neck fracture. The purpose of this study was to assess the femoral head vascularity after femoral neck fracture using single photon emission computerized tomography and computerized tomography (SPECT/CT), and to evaluate its value in predicting ONFH.
  
  
  METHODS
  Between January 2008 and March 2011, 120 patients diagnosed with femoral neck fracture underwent SPECT-CT before the internal fixation. The fracture was classified according to the Garden classification. The ratios of the radionuclide uptake of the fractured femoral head to that of the contralateral femoral head (F/N) were calculated to assess the femoral head vascularity. After a minimum of two years' follow-up, magnetic resonance imaging (MRI) was used as the "gold standard" for the diagnosis of possible ONFH.
  
  
  RESULTS
  A total of 114 patients completed the study. The SPECT/CT examination showed that the F/N ratios of Garden I, II, III and IV were 2.6, 1.8, 0.8, and 0.6, respectively. At the time of the most recent follow-up, osteonecrosis developed in two of the 27 patients who had a Garden Stage-II fracture, in eight of the 34 patients who had a Garden Stage-III fracture, and nine of the 27 patients who had a Garden Stage-VI fracture. With a cutoff of 0.55 from the receiver operating characteristic (ROC) curve, F/N ratio showed a sensitivity of 97%, a specificity of 79%, a positive predictive value of 95%, and a negative predictive value of 19%.
  
  
  CONCLUSIONS
  SPECT-CT proved to be reliable and valid for predicting ONFH after femoral neck fracture.
authors.affiliation: Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Heng-feng
authors.initials: HF
authors.lastname: Yuan
authors.forename: Feng
authors.initials: F
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Hong-cheng
authors.initials: HC
authors.lastname: Shi
authors.forename: Yu-shen
authors.initials: YS
authors.lastname: Gu
authors.forename: Zuo-qin
authors.initials: ZQ
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005265:Femoral Neck Fractures / Q000150:complications* / Q000601:surgery; D005270:Femur Head / Q000098:blood supply* / Q000601:surgery*; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D005593:Fracture Fixation, Internal; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed