title: Copaiba oil effect on experimental jaw defect in Wistar rats.
abstract: OBJECTIVE
  To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue.
  
  
  METHODS
  A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects.
  
  
  RESULTS
  The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60).
  
  
  CONCLUSIONS
  The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated with meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model.
authors.affiliation: Postgraduate Program in Clinical Dentistry, Federal University of Para, Brazil.
authors.forename: Priscilla Flores
authors.initials: PF
authors.lastname: Silva
authors.affiliation: Medical School, State University of Para, Brazil.
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
authors.affiliation: Dentistry School, UFPA, Belem, PA, Brazil.
authors.forename: Flávia Sirotheau Correa
authors.initials: FS
authors.lastname: Pontes
authors.affiliation: UEPA, Belem, PA, Brazil.
authors.forename: Suzana Rodrigues
authors.initials: SR
authors.lastname: Ramos
authors.affiliation: UFPA, Belem, PA, Brazil.
authors.forename: Laís Cordeiro
authors.initials: LC
authors.lastname: Mendes
authors.affiliation: UFPA, Belem, PA, Brazil.
authors.forename: Louize Caroline Marques
authors.initials: LC
authors.lastname: Oliveira
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use; D002516:Ceramics / Q000627:therapeutic use; D004195:Disease Models, Animal; D007887:Fabaceae / Q000737:chemistry*; D007568:Jaw / Q000187:drug effects* / Q000503:physiopathology; D007569:Jaw Abnormalities / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D000077239:Meloxicam; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology; D010012:Osteogenesis / Q000187:drug effects*; D010938:Plant Oils / Q000494:pharmacology*; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013843:Thiazines / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C022107:Bioglass; D018786:Bone Substitutes; D010938:Plant Oils; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam