title: Anti-VEGF intravitreal bevacizumab for radiation-associated neovascular glaucoma.
abstract: OBJECTIVE
  To report outcomes of intravitreal bevacizumab therapy in radiation-associated neovascular glaucoma (NVG).
  
  
  METHODS
  In this retrospective interventional case series, 12 eyes with NVG after radiation therapy for ocular malignancy were treated with periodic intravitreal injections of 1.25 mg bevacizumab. Outcome measures included changes in iris neovascularization, intraocular pressure (IOP), visual acuity, and pain.
  
  
  RESULTS
  One month after the first injection, iris neovascularization regressed in nine of 12 eyes (75%), and IOP decreased in eight of 12 eyes (67%) by a mean of 10.1 mm Hg. Patients were monitored for a mean of 26.5 months after their first injection. Six eyes subsequently underwent enucleation for pain control (four eyes; 66%), chronic uveitis (one eye; 17%), and tumor recurrence (one eye; 17%). All remaining patients experienced deterioration in visual acuity (range: 20/160 to no light perception), but pain control was good and IOP normalized in four patients.
  
  
  CONCLUSIONS
  Intravitreal bevacizumab therapy should be considered for patients with radiation-associated NVG who wish to avoid enucleation.
authors.forename: Sonali T
authors.initials: ST
authors.lastname: Nagendran
authors.forename: Paul T
authors.initials: PT
authors.lastname: Finger
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000068258:Bevacizumab; D001918:Brachytherapy / Q000009:adverse effects*; D058447:Eye Pain; D005260:Female; D015355:Glaucoma, Neovascular / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007429:Intraocular Pressure; D058449:Intravitreal Injections; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy; D008875:Middle Aged; D010165:Palladium; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D011868:Radioisotopes; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000473:pathology / Q000532:radiotherapy; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; D007457:Iodine Radioisotopes; D011868:Radioisotopes; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; D010165:Palladium