title: A resected case of intraductal tubulopapillary neoplasm of the pancreas: report of a case.
abstract: The patient was a 61-year-old male who was referred to our hospital after dilatation of the main pancreatic duct was detected by screening ultrasonography. Computed tomography revealed a protruding lesion measuring 15 mm in diameter within the main pancreatic duct in the head of the pancreas, and magnetic resonance cholangiopancreatography revealed interruption of the duct at the tumor site. We performed pancreaticoduodenectomy under a suspected diagnosis of invasive ductal carcinoma. Gross examination of the resected specimen showed that the tumor invaginated into the main pancreatic duct, and no mucin was found. Histological examination revealed proliferation of high-grade dysplastic cells in a tubulopapillary growth pattern. Immunohistochemically, cytokeratin 7 expression was detected, but not trypsin expression. Based on these morphological features, we diagnosed the tumor as intraductal tubulopapillary neoplasm (ITPN). We report the case with bibliographic consideration, together with a review of intraductal neoplasms of the pancreas encountered at our institution.
authors.affiliation: 1 Division of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba Prefecture, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kato
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kojima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okubo
authors.forename: Daigoro
authors.initials: D
authors.lastname: Takahashi
authors.forename: Rei
authors.initials: R
authors.lastname: Okada
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nishida
authors.forename: Naoto
authors.initials: N
authors.lastname: Gotohda
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Takahashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Konishi
mesh_terms: D044584:Carcinoma, Ductal / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D049448:Cholangiopancreatography, Magnetic Resonance; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D014357:Trypsin / Q000032:analysis
chemical_list: D053552:Keratin-7; D014357:Trypsin
keywords: Intraductal neoplasms of the pancreas; Intraductal tubulopapillary neoplasm (ITPN); Pancreaticoduodenectomy