title: Total ischaemic time and 9-year outcomes in STEMI patients treated with pPCI.
abstract: BACKGROUND
  Prolonged total ischaemic time (TIT) has been shown to independently predict poor myocardial perfusion in STEMI patients and affect in-hospital mortality. We aim to evaluate the influence of TIT on long-term follow-up (F/U) and identify the factors associated with TIT in patients with STEMI treated with pPCI at a high volume centre.
  
  
  METHODS
  In a prospective "all-comer" registry, clinical, angiographic and procedural characteristics, TIT and 9-year mortality were determined in consecutive STEMI patients treated with pPCI. Patients were divided according to TIT into three groups: A) <3, B) 3-6 and C) >6h.
  
  
  RESULTS
  Among 1064 patients, TIT was known in 1002 patients, 5 patients were lost to F/U. For censored observations F/U was 7.2-8.8 years. There were 350, 461, and 186 patients in groups A, B, and C, respectively. Patients in group A compared to B and C were younger, more often males and smokers, less frequently had history of CAD, and more frequently had occluded infarct related artery. However, final TIMI3 was obtained more frequently. Overall 30-day mortality was 4%, one-year mortality 7% and nine-year mortality 27%. Multivariable logistic regression models indicated that longer TIT was associated with a higher risk of 9-year mortality (A-21%, B-28%, C-37%, p<0.0005). TIT>6h was independently associated with advanced age, diabetes mellitus, history of CAD and higher rate of initial TIMI grade flow 3.
  
  
  CONCLUSIONS
  TIT is strongly related with mortality in STEMI patients even after nine years of F/U. This finding reinforces the necessity of shortening the TIT in all STEMI patients.
authors.affiliation: Institute of Cardiology, Department of Interventional Cardiology and Angiology, Warsaw, Poland. Electronic address: magdapolanska@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Polańska-Skrzypczyk
authors.affiliation: Institute of Cardiology, Department of Interventional Cardiology and Angiology, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Karcz
authors.affiliation: Institute of Cardiology, Department of Interventional Cardiology and Angiology, Warsaw, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Bekta
authors.affiliation: Institute of Cardiology, Department of Coronary and Structural Heart Diseases, Warsaw, Poland.
authors.forename: C
authors.initials: C
authors.lastname: Kępka
authors.affiliation: Medical University of Bialystok, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Sielatycki
authors.affiliation: Institute of Cardiology, Department of Coronary and Structural Heart Diseases, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Rużyłło
authors.affiliation: Institute of Cardiology, Department of Interventional Cardiology and Angiology, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Witkowski
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D062645:Percutaneous Coronary Intervention / Q000401:mortality / Q000639:trends*; D011446:Prospective Studies; D012042:Registries; D013997:Time Factors; D016896:Treatment Outcome
keywords: Primary percutaneous coronary intervention (pPCI); Prognostic factors; ST-elevation myocardial infarction (STEMI); Total ischaemic time (TIT)