title: Effect of the Y chromosome on testis weight in mice.
abstract: We investigated the effect of the Y chromosome on testis weight in (B6.Cg-A(y) × Y-consomic mouse strain) F1 male mice. We obtained the following results: (1) Mice with the Mus musculus domesticus-type Y chromosome had significantly heavier testis than those with the M. m. musculus-type Y chromosome. (2) Variations in Usp9y and the number of CAG repeats in Sry were significantly associated with testes weight. The A(y) allele was correlated with a reduced testis weight, and the extent of this reduction was significantly associated with a CAG repeat number polymorphism in Sry. These results suggest that Y chromosome genes not only influence testis weight but also modify the effect of the A(y) allele in mediating this phenomenon.
authors.affiliation: Center for Animal Disease Control and Prevention, National Institute of Animal Health, Tsukuba, Ibaraki 305-0856, Japan.
authors.forename: Kunio
authors.initials: K
authors.lastname: Satou
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Suto
mesh_terms: D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D010450:Endopeptidases / Q000235:genetics*; D008297:Male; D051379:Mice; D015778:Minor Histocompatibility Antigens; D009929:Organ Size / Q000235:genetics / Q000502:physiology; D051876:Sex-Determining Region Y Protein / Q000235:genetics*; D013045:Species Specificity; D013737:Testis / Q000033:anatomy & histology* / Q000502:physiology; D018911:Trinucleotide Repeats / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics* / Q000502:physiology
chemical_list: D015778:Minor Histocompatibility Antigens; D051876:Sex-Determining Region Y Protein; C497746:Sry protein, mouse; D010450:Endopeptidases; C481723:Usp9y protein, mouse