title: Chlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats.
abstract: This study aimed to assess the local anesthetic effects of chlorpheniramine in spinal anesthesia and is compared with mepivacaine, a widely-used local anesthetic. Spinal anesthesia with chlorpheniramine and mepivacaine was constructed in a dosage-dependent fashion after the rats were injected intrathecally. The spinal block effect of chlorpheniramine in motor function, nociception, and proprioception was compared to that of mepivacaine. We revealed that intrathecal chlorpheniramine and mepivacaine exhibited a dose-dependent spinal block of motor function, nociception, and proprioception. On the 50% effective dose (ED50) basis, the ranks of potencies in motor function, nociception, and proprioception were chlorpheniramine>mepivacaine (P<0.01 for the differences). On the equianesthetic basis (ED25, ED50, ED75), the duration of spinal anesthesia with chlorpheniramine was greater than that of mepivacaine (P<0.01 for the differences). Instead of mepivacaine, chlorpheniramine produced a greater duration of sensory blockade than the motor blockade. These preclinical data showed that chlorpheniramine has a better sensory-selective action over motor block to produce more potent and long-lasting spinal anesthesia than mepivacaine.
authors.affiliation: Department of Anesthesiology, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan.
authors.forename: Jann-Inn
authors.initials: JI
authors.lastname: Tzeng
authors.affiliation: Department of Physical Medicine and Rehabilitation, Madou Sin-Lau Hospital, Tainan City, Taiwan; Department of Nursing, Chung Hwa University of Medical Technology, Tainan City, Taiwan.
authors.forename: Heng-Teng
authors.initials: HT
authors.lastname: Lin
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan City, Taiwan; Department of Physical Therapy, China Medical University, Taichung City, Taiwan.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Physical Therapy, National Cheng Kung University, Tainan City, Taiwan. Electronic address: chhung@mail.ncku.edu.tw.
authors.forename: Ching-Hsia
authors.initials: CH
authors.lastname: Hung
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan City, Taiwan.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002744:Chlorpheniramine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D059225:Nociception / Q000187:drug effects*; D011434:Proprioception / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology*; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D002744:Chlorpheniramine
keywords: Chlorpheniramine; Mepivacaine; Motor function; Nociception; Proprioception; Spinal block