title: Reproducibility of peripapillary retinal nerve fiber layer thickness measurements with cirrus HD-OCT in glaucomatous eyes.
abstract: OBJECTIVE
  To assess the reproducibility of Cirrus high-definition optical coherence tomography (HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) for analysis of peripapillary retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes.
  
  
  METHODS
  Forty-five eyes (one eye from each glaucomatous patient) were imaged with Cirrus HD-OCT. Each eye was imaged three times by two separate operators. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest variability were evaluated for both intraobserver and interobsever measurements.
  
  
  RESULTS
  In intraobserver measurements, the average RNFL thickness ICC was 0.983. CV and test-retest variability were 2.3% and 4.4 µm respectively. In quadrants ICC ranged from 0.886 to 0.956, the lowest associated with nasal quadrant and CV ranged from 3.6% to 7.7%. In interobsever measurements, the average RNFL thickness ICC was 0.979. CV and test-retest variability were 2.4% and 4.5 µm respectively. In quadrants ICC ranged from 0.886 to 0.957, the lowest associated with nasal quadrant and CV ranged from 3.8% to 8.6%.
  
  
  CONCLUSIONS
  The reproducibility of Cirrus OCT for RNFL thickness is sufficiently good to be useful clinically as a measure of glaucoma progression.
authors.affiliation: Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Soltani-Moghadam
authors.affiliation: Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Alizadeh
authors.affiliation: Eye Research Center, Amiralmomenin Hospital, Guilan University of Medical Sciences, Rasht 4139637459, Iran.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Kazemnezhad Leili
authors.affiliation: Guilan University of Medical Sciences, Rasht 4139637459, Iran.
authors.forename: Mohamadreza
authors.initials: M
authors.lastname: Absari Haghighi
keywords: glaucoma; optical coherence tomography; reproducibility; retinal nerve fiber layer