title: Primary Osteosarcoma of the Sternum: A case Report and Review of the Literature.
abstract: Osteosarcoma (osteogenic sarcoma: OS) is the most common primary malignant bone tumor of long bones, whereas primary osteosarcoma of chest wall, especially in sternum, is extremely rare. We report a 57-year-old man with an immobile slow growing mass located in the middle of the sternum. The patient had no significant pain or tenderness and the past medical history was not remarkable. CT-scan showed a large densely sclerotic sternal mass and MRI revealed an extensive central signal loss within the tumor because of necrosis. We performed a CT-guided needle biopsy, but it was inconclusive. After an incisional biopsy, a high-grade osteosarcoma of the sternum was diagnosed. The patient underwent subtotal sternal resection and reconstruction using synthetic mesh and bone cement followed by chemotherapy and external beam radiotherapy. After one year of follow-up, the patient is back to normal life and is doing the daily activities without problem. By this time, focal recurrence or metastatic disease did not occur.
authors.affiliation: Masoud Pezeshki Rad MD, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Masoud Pezeshki
authors.initials: MP
authors.lastname: Rad
authors.affiliation: Masoud Pezeshki Rad MD, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Seyd Hosein
authors.initials: SH
authors.lastname: Fattahi Masoum
authors.affiliation: Masoud Pezeshki Rad MD, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Layegh
authors.affiliation: Masoud Pezeshki Rad MD, Vascular and Endovascular Surgery Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohsen Salari
authors.initials: MS
authors.lastname: Rad
keywords: Chest wall tumor; Osteosarcoma; Sternum