title: Platelet Aggregation Study in Patients With Hemoglobin Eβ Thalassemia in India.
abstract: Hemoglobin Eβ thalassemia is a major public health problem in India, especially in the state of West Bengal. Various thromboembolic events are common, especially in splenectomized patients. Platelet hyperactivity most likely plays a pathogenetic role. To investigate the role of platelets in hypercoagulability, platelet aggregation tests were undertaken in the present study. Platelet-rich plasma from 30 patients with Eβ thalassemia (15 splenectomized and 15 nonsplenectomized) were studied and compared with 15 healthy participants. The 4 agonists used were adenosine 5-diphosphate, adrenaline (epinephrine), collagen, and ristocetin. The current study shows both splenectomized and nonsplenectomized patients had abnormal aggregation compared to normal healthy controls. Splenectomized patients had higher platelet aggregation than nonsplenectomized patients for all 4 agonists; but statistically significant difference among 2 groups was found only for collagen. The present study confirms a role of splenic absence in platelet hyperaggregation.
authors.affiliation: Department of Pathology, R.G. KAR Medical College, Kolkata, India.
authors.forename: Tanushree
authors.initials: T
authors.lastname: Ghosal
authors.affiliation: Department of Hematology, NRS Medical College, Kolkata, India.
authors.forename: Tuphan Kanti
authors.initials: TK
authors.lastname: Dolai
authors.affiliation: Department of Hematology, NRS Medical College, Kolkata, India prakas70@gmail.com.
authors.forename: Prakas Kumar
authors.initials: PK
authors.lastname: Mandal
authors.affiliation: Department of Hematology, NRS Medical College, Kolkata, India.
authors.forename: S
authors.initials: S
authors.lastname: Karthik
authors.affiliation: Department of Pathology, R.G. KAR Medical College, Kolkata, India.
authors.forename: Anjali
authors.initials: A
authors.lastname: Bandyopadhyay
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D010974:Platelet Aggregation; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects; D013923:Thromboembolism / Q000209:etiology; D019851:Thrombophilia / Q000209:etiology; D017086:beta-Thalassemia / Q000097:blood* / Q000150:complications / Q000628:therapy
keywords: Eβ thalassemia; platelet aggregation tests; splenectomy