title: Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder.
abstract: Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with a clear genetic component (Nicolini et al., 2009) in which neurodevelopmental mechanisms may be etiologically important. Brain-derived neurotrophic factor (BDNF) is an interesting candidate for molecular analysis in OCD on the basis of potential functional relevance, positive association studies, and reported interaction between this gene and other neurotransmitters implicated in this disorder.
authors.affiliation: aNeurogenetics Section, Centre for Addiction and Mental Health bDepartment of Psychiatry and Institute of Medical Science, University of Toronto cDepartment of Psychiatry and Program in Genetics and Genome Biology, Hospital for Sick Children dFrederick W. Thompson Anxiety Disorders Centre and Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: Gwyneth
authors.initials: G
authors.lastname: Zai
authors.forename: Clement C
authors.initials: CC
authors.lastname: Zai
authors.forename: Paul D
authors.initials: PD
authors.lastname: Arnold
authors.forename: Natalie
authors.initials: N
authors.lastname: Freeman
authors.forename: Eliza
authors.initials: E
authors.lastname: Burroughs
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Richter
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human