title: Computed tomography-guided iodine-125 interstitial implantation as an alternative treatment option for lung cancer.
abstract: OBJECTIVE
  The aim was to evaluate the safety, feasibility and efficacy of computed tomography (CT)-guided percutaneous interstitial brachytherapy using radioactive iodine-125 ( 125 I) seeds for the treatment of lung cancer.
  
  
  METHODS
  Included in this study were 45 male and 35 female patients aged 52-85 years (mean 72-year) who were diagnosed with lung cancer. Of the 80 cases of lung cancer, 38 were pathologically confirmed as squamous cell carcinoma, 29 as adenocarcinoma, 2 as small cell lung cancer, and 11 as metastatic lung cancer. Percutaneous interstitial implantation of radioactive 125 I seeds was performed under CT guidance. The treatment planning system was used to reconstruct three-dimensional images of the tumor to determine the quantity and distribution of 125 I seeds to be implanted. Under CT guidance, 125 I seeds were embedded into the tumor, with the matched peripheral dose set at 100-130 Gy. Follow-up CT scan was done in 2-month to explore the treatment efficacy.
  
  
  RESULTS
  The procedure was successful in all patients. No major procedure-associated death occurred. The duration of follow-up was 6-month. Complete response (CR) was seen in 38 cases (47.5%), partial response (PR) in 27 cases (33.75%), stable disease (SD) in 10 cases (12.5%), and progressive disease in 5 cases (6.25%), with a local control rate (CR + PR + SD) of 93.75%. The 2-, 4- and 6-month overall response rate (CR + PR) was 78%, 83% and 81%, respectively.
  
  
  CONCLUSIONS
  Implantation of CT-guided 125 I seeds is a safe and effective alternative option for the treatment of lung cancer.
authors.forename: G
authors.initials: G
authors.lastname: Jiang
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Ding
authors.forename: F
authors.initials: F
authors.lastname: Zhou
authors.forename: W
authors.initials: W
authors.lastname: Jiao
authors.forename: D
authors.initials: D
authors.lastname: Tang
authors.forename: W
authors.initials: W
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Yue
authors.affiliation: Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors.forename: W
authors.initials: W
authors.lastname: Xu
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy* / Q000556:secondary; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D055752:Small Cell Lung Carcinoma / Q000532:radiotherapy* / Q000556:secondary; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes