title: Antimicrobial resistance surveillance of flomoxef in China.
abstract: The aim of this study was to investigate the susceptibility of flomoxef against clinical isolates collected from China and understand the trend of antimicrobial resistance. A total of 2955 pathogenic strains isolated from 18 tertiary hospitals in 18 cities of China over the period from July 2011 to June 2012 were studied. And the susceptibility tests were performed using agar dilution method recommended by CLSI in central laboratory. Flomoxef showed good potency against Enterobacteriaceae with susceptibility rate 85%-100%. The susceptibility rates of flomoxef against Staphylococcus spp. isolates were 63.9%-92.2%; 98.8% of MSSA and 88.2% of MSSE were susceptible to this drug. For other tested bacteria including Moraxella catarrhalis, Haemophilus spp., and Streptococcus spp. (except Viridans group streptococci) flomoxef showed good potency with susceptibility rate more than 95%. All these results strongly suggest that flomoxef is a potent antibacterial agent against major pathogens in China.
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Lanqing
authors.initials: L
authors.lastname: Cui
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China. Electronic address: lvyuan0901@sina.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xue
authors.affiliation: Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D002681:China; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects; D006190:Haemophilus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000187:drug effects; D062486:Public Health Surveillance; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C045693:flomoxef
keywords: Antimicrobial resistance surveillance; Flomoxef; Minimum inhibitory concentration; Resistance; Susceptibility