title: The good, the bad and the ugly: surgical resection for non-colorectal, non-neuroendocrine liver metastases.
abstract: OBJECTIVE
  The aim of this retrospective study was to analyze outcomes after partial hepatectomy for non-colorectal non-neuroendocrine metastases (mNCRNNE) and to identify prognostic factors associated with survival.
  
  
  METHODS
  Patient demographics, tumor characteristics, treatment and outcome of 30 consecutive patients operated between January 1995 and June 2012 were analyzed. The Kaplan-Meier method was used to analyze survival and Cox regression models were applied to identify independent prognostic variables.
  
  
  RESULTS
  NCRNNE primaries included stomach (n=13), breast (n=5), pancreas (n=3), choroid melanoma (n=2), unknown primary (n=1) and others (n=6). Thirty-day mortality. rate was 3.3% and morbidity rate was 23.3%. Following hepatectomy, median overall (OS) and disease- free survival (DFS) were 24 and 12 months, respectively. In univariate analysis, longer disease-free interval (p=0.04) was associated with better OS. Histology of the primary tumor (p=0.003) and the presence of extrahepatic disease (p=0.04) were associated with a lower DFS. Cox regression analysis identified histology as an independent prognostic factor for DFS (p=0.013).
  
  
  CONCLUSIONS
  In selected patients, resection of mNCRNNE appears associated with prolonged survival and may be performed in a specialized environment with acceptable morbidity and mortality. Patients with a longer disease-free interval, specific primary location and histology and absence of extra-hepatic disease seem to benefit the most from this approach.
authors.forename: Ana Beatriz
authors.initials: AB
authors.lastname: Almeida
authors.forename: Renato
authors.initials: R
authors.lastname: Bessa de Melo
authors.forename: Luís Afonso
authors.initials: LA
authors.lastname: Graça
authors.forename: José
authors.initials: J
authors.lastname: Costa Maia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models