title: Lymphoproliferative disease and cancer among patients with common variable immunodeficiency.
abstract: Innate immune deficiencies are a heterogeneous group of genetically inherited diseases affecting the innate and adaptive immune systems that confer susceptibility to infection, autoimmunity, and cancer. This review discusses the latest insights into the links between common variable immunodeficiency (CVI) and malignancies. Although Ig therapy greatly reduces the number of infections and enhances survival, it does not appear to address the development of cancer, especially lymphoma. The reasons for the increased susceptibility to lymphoid malignancies are unclear. These include genetics, immune dysregulation, radiosensitivity and chronic infections such as Helicobacter pylori, EBV, human herpes virus type 8 and cytomegalovirus. Further studies will allow us to better stratify the risk for cancer in these patients, and teach us to better prevent these complications and to better treat them.
authors.affiliation: School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", Messina, Italy; Institute of Clinical Physiology, IFC CNR, Messina Unit, Messina, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gangemi
authors.affiliation: Division of Hematology, Department of General Surgery and Oncology, University of Messina, Messina, Italy. Electronic address: aallegra@unime.it.
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.affiliation: Division of Hematology, Department of General Surgery and Oncology, University of Messina, Messina, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Musolino
mesh_terms: D017074:Common Variable Immunodeficiency / Q000150:complications*; D004198:Disease Susceptibility; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D009369:Neoplasms / Q000209:etiology*; D012307:Risk Factors
keywords: Common variable immunodeficiency; Gastric cancer; Immune dysregulation; Innate immune deficiency; Lymphoma