title: Change in aneurysmal flow pulsatility after flow diverter treatment.
abstract: Treatment of intracranial aneurysms with flow diverters (FDs) has recently become an attractive alternative. Although considerable effort has been devoted to understand their effects on the time-averaged or peak systolic flow field, no previous study has analyzed the variability of FD-induced flow reduction along the cardiac cycle.
  
  
  
  Fourteen saccular aneurysms, candidates for FD treatment because of their morphology, located on the internal carotid artery were virtually treated with FDs and pre- and post-treatment blood flow was simulated with CFD techniques. Common hemodynamic variables were recorded at each time step of the cardiac cycle and differences between the untreated and treated models were assessed.
  
  
  
  Flow pulsatility, expressed by the pulsatility index (PI) of the velocity, significantly increased (36.0%; range: 14.6-88.3%) after FD treatment. Peak systole velocity reduction was significantly smaller (30.5%; range: 19.6-51.0%) than time-averaged velocity reduction (43.0%; range: 29.1-69.8%). No changes were observed in the aneurysmal pressure.
  
  
  
  FD-induced flow reduction varies considerably during the cardiac cycle. FD treatment significantly increased the flow pulsatility in the aneurysm.
authors.affiliation: PLADEMA-CONICET, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina. Electronic address: larrabide@exa.unicen.edu.ar.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Larrabide
authors.affiliation: Universitat Pompeu Fabra, Barcelona, Spain.
authors.forename: Arjan J
authors.initials: AJ
authors.lastname: Geers
authors.affiliation: Medisys, Philips Research, Paris, France.
authors.forename: Hernán G
authors.initials: HG
authors.lastname: Morales
authors.affiliation: Neurochirurgie, Département de Neurosciences Cliniques, Faculté de Médecine, Université de Genéve, Genéve, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bijlenga
authors.affiliation: Hirslanden Clinic, Zürich, Switzerland.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Rüfenacht
mesh_terms: D001783:Blood Flow Velocity; D002343:Carotid Artery, Internal; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology / Q000628:therapy
keywords: Flow diverter; Intracranial aneurysms; Time dependency; Velocity; WSS