title: RASSF4 promotes EV71 replication to accelerate the inhibition of the phosphorylation of AKT.
abstract: Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China.
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Yongjuan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Dong
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Bingfei
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Song
authors.initials: S
authors.lastname: Han
authors.affiliation: Institute of Neuropsychiatry, Renmin Hospital, Wuhan University, Wuhan 430060, China.
authors.forename: Zhongchun
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
authors.forename: Biwen
authors.initials: B
authors.lastname: Peng
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China. Electronic address: hexiaohua@whu.edu.cn.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: He
authors.affiliation: Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China. Electronic address: liuwanhong@whu.edu.cn.
authors.forename: Wanhong
authors.initials: W
authors.lastname: Liu
mesh_terms: D017209:Apoptosis; D002460:Cell Line; D029821:Enterovirus A, Human / Q000502:physiology*; D006232:Hand, Foot and Mouth Disease / Q000503:physiopathology / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D010766:Phosphorylation; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D014779:Virus Replication
chemical_list: C495500:RASSF4 protein, human; D025521:Tumor Suppressor Proteins; D051057:Proto-Oncogene Proteins c-akt
keywords: AKT phosphorylation; Enterovirus 71; RASSF4; Replication