title: Ritonavir-boosted indinavir but not lopinavir inhibits erythrocytic stage Plasmodium knowlesi malaria in rhesus macaques.
abstract: The inhibitive activities of the human immunodeficiency virus protease inhibitors ritonavir (RTV) boosted indinavir (IDV) and RTV boosted lopinavir (LPV) for erythrocytic stage malaria were evaluated in rhesus macaques. The IDV/RTV regimen effectively inhibits the replication of Plasmodium knowlesi with clinically relevant doses, whereas the LPV/RTV regimen did not show activity against plasmodium infection.
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qin
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.
authors.forename: Limei
authors.initials: L
authors.lastname: Qin
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.
authors.forename: Wanwan
authors.initials: W
authors.lastname: Xu
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China.
authors.forename: Siting
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Laboratory of Pathogen Biology, State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, No. 190, Kaiyuan Avenue, Guangzhou Science Park, Guangzhou 510530, China. Electronic address: chen_xiaoping@gibh.ac.cn.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000469:parasitology; D019469:Indinavir / Q000494:pharmacology*; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D016790:Plasmodium knowlesi / Q000187:drug effects*; D019438:Ritonavir / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D019469:Indinavir; D019438:Ritonavir
keywords: Indinavir; Lopinavir; Plasmodium knowlesi; Rhesus macaques; Ritonavir