title: Nickel-catalyzed amination of aryl chlorides with ammonia or ammonium salts.
abstract: The nickel-catalyzed amination of aryl chlorides to form primary arylamines occurs with ammonia or ammonium sulfate and a well-defined single-component nickel(0) precatalyst containing a Josiphos ligand and an η(2)-bound benzonitrile ligand. This system also catalyzes the coupling of aryl chlorides with gaseous amines in the form of their hydrochloride salts.
authors.affiliation: Department of Chemistry, University of California, Berkeley, Berkeley, California 94720 (USA).
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Green
authors.forename: John F
authors.initials: JF
authors.lastname: Hartwig
mesh_terms: D000586:Amination; D000641:Ammonia / Q000737:chemistry*; D064751:Ammonium Compounds / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008024:Ligands; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry
chemical_list: D064751:Ammonium Compounds; D008024:Ligands; D009570:Nitriles; D000641:Ammonia; D009532:Nickel; C014356:benzonitrile
keywords: amination; ammonia; arylation; cross-coupling; nickel