title: Bioinformatics tools for small genomes, such as hepatitis B virus.
abstract: DNA sequence analysis is undertaken in many biological research laboratories. The workflow consists of several steps involving the bioinformatic processing of biological data. We have developed a suite of web-based online bioinformatic tools to assist with processing, analysis and curation of DNA sequence data. Most of these tools are genome-agnostic, with two tools specifically designed for hepatitis B virus sequence data. Tools in the suite are able to process sequence data from Sanger sequencing, ultra-deep amplicon resequencing (pyrosequencing) and chromatograph (trace files), as appropriate. The tools are available online at no cost and are aimed at researchers without specialist technical computer knowledge. The tools can be accessed at http://hvdr.bioinf.wits.ac.za/SmallGenomeTools, and the source code is available online at https://github.com/DrTrevorBell/SmallGenomeTools.
authors.affiliation: Hepatitis Virus Diversity Research Programme (HVDRP), Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa. TrevorGrahamBell@gmail.com.
authors.forename: Trevor G
authors.initials: TG
authors.lastname: Bell
authors.affiliation: Hepatitis Virus Diversity Research Programme (HVDRP), Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2050, South Africa. Anna.Kramvis@wits.ac.za.
authors.forename: Anna
authors.initials: A
authors.lastname: Kramvis
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D016679:Genome, Viral; D023281:Genomics / Q000379:methods*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D020407:Internet