title: Oasis: online analysis of small RNA deep sequencing data.
abstract: Oasis is a web application that allows for the fast and flexible online analysis of small-RNA-seq (sRNA-seq) data. It was designed for the end user in the lab, providing an easy-to-use web frontend including video tutorials, demo data and best practice step-by-step guidelines on how to analyze sRNA-seq data. Oasis' exclusive selling points are a differential expression module that allows for the multivariate analysis of samples, a classification module for robust biomarker detection and an advanced programming interface that supports the batch submission of jobs. Both modules include the analysis of novel miRNAs, miRNA targets and functional analyses including GO and pathway enrichment. Oasis generates downloadable interactive web reports for easy visualization, exploration and analysis of data on a local system. Finally, Oasis' modular workflow enables for the rapid (re-) analysis of data.
  
  
  METHODS
  Oasis is implemented in Python, R, Java, PHP, C++ and JavaScript. It is freely available at http://oasis.dzne.de.
  
  
  BACKGROUND
  stefan.bonn@dzne.de
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Capece
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Julio C
authors.initials: JC
authors.lastname: Garcia Vizcaino
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Ramon
authors.initials: R
authors.lastname: Vidal
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Raza-Ur
authors.initials: RU
authors.lastname: Rahman
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Tonatiuh
authors.initials: T
authors.lastname: Pena Centeno
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Orr
authors.initials: O
authors.lastname: Shomroni
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Irantzu
authors.initials: I
authors.lastname: Suberviola
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Andre
authors.initials: A
authors.lastname: Fischer
authors.affiliation: Laboratory of Computational Systems Biology and Laboratory of Epigenetic Mechanisms in Dementia, German Center for Neurodegenerative Diseases, 37077 Goettingen, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Bonn
mesh_terms: D019295:Computational Biology / Q000379:methods*; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods*; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000032:analysis* / Q000235:genetics; D009862:Online Systems; D017423:Sequence Analysis, RNA / Q000379:methods*; D012984:Software
chemical_list: D035683:MicroRNAs