title: [Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients].
abstract: BACKGROUND
  Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients.
  
  
  METHODS
  We studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg . kg-1 of sugammadex was administered. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.
  
  
  RESULTS
  For the rocuronium-induced neuromuscular block, the mean recovery time of the T4/T1 ratio to 0.9 decreased from 66.9 min in the sugammadex 0.5 mg kg-1 group to 1.3 min in the sugammadex 8.0 mg kg-1 group. For the vecuronium-induced neuromuscular block it decreased from 79.5 min in the sugammadex 0.5 mg . kg-1 group to 2.9 min in the sugammadex 8.0 mg . kg-1 group. No clinical evidence of recurarization or residual curarization was observed.
  
  
  CONCLUSIONS
  The efficacy and safety of sugammadex were confirmed in Japanese surgical patients for reversal from deep block.
authors.forename: Junzo
authors.initials: J
authors.lastname: Takeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwasaki
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Otagiri
authors.forename: Takasumi
authors.initials: T
authors.lastname: Katoh
authors.forename: Koh
authors.initials: K
authors.lastname: Shingu
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Obara
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakatsuka
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kasaba
mesh_terms: D000328:Adult; D000732:Androstanols / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D044466:Asian People; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D000077123:Rocuronium; D000077122:Sugammadex; D014673:Vecuronium Bromide / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D047408:gamma-Cyclodextrins / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D014673:Vecuronium Bromide; D000077123:Rocuronium