title: Dynamic combinatorial enrichment of polyconformational D-/L-peptide dimers.
abstract: D-/L-peptides such as gramicidin A (gA) adopt unique dimeric β-helical structures of different topologies. To overcome their conformational promiscuity and enrich individual components, a dynamic combinatorial approach assisted by thiol tags was developed. This method led to identification of the preferential formation of antiparallel dimers under a broad range of conditions, which was independent of peptide side-chain polarity. Exclusive formation of an antiparallel cyclic dimer was achieved in the presence of cesium ions.
authors.affiliation: Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University, Humboldtstr. 10, 07743 Jena (Germany), Fax: (+49) 3641-9-48212.
authors.forename: Kirtikumar B
authors.initials: KB
authors.lastname: Jadhav
authors.forename: Roman J
authors.initials: RJ
authors.lastname: Lichtenecker
authors.forename: Anke
authors.initials: A
authors.lastname: Bullach
authors.forename: Bhubaneswar
authors.initials: B
authors.lastname: Mandal
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Arndt
mesh_terms: D000595:Amino Acid Sequence; D006096:Gramicidin / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D055503:Protein Multimerization; D017433:Protein Structure, Secondary; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D010455:Peptides; D013438:Sulfhydryl Compounds; D006096:Gramicidin
keywords: beta-helix; combinatorial chemistry; disulfides; gramicidin A; peptides