title: Synthesis of orotidine by intramolecular nucleosidation.
abstract: An intramolecular nucleosidation approach provides easy access to orotidine in high yields. Notably, orotate itself is used as a leaving group at the anomeric position. This method has the potential for facile access to derivatives of orotidine of therapeutic interest, with implications for prebiotic formation of nucleosides.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, California. rkrishna@scripps.edu.
authors.forename: E-K
authors.initials: EK
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Krishnamurthy
mesh_terms: D008968:Molecular Conformation; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C008714:orotidine; D014529:Uridine