title: Carbon monoxide-releasing molecule-A1 (CORM-A1) improves clinical signs of experimental autoimmune uveoretinitis (EAU) in rats.
abstract: Uveitis is a sight-threatening inflammatory disease of the eye which represents the third leading cause of blindness in the developed countries. The conventional pharmacological treatment includes corticosteroids and immunosuppressive agents, which are limited by their side effects. New therapeutic strategies are thus strongly needed. Exogenously-administered carbon monoxide (CO) may represent an effective treatment for conditions characterized by a dysregulated inflammatory response. Carbon monoxide-releasing molecules (CORMs) are a novel group of compounds capable of carrying and liberating controlled quantities of CO. Among CORMs, CORM-A1 represents the first example of water soluble CO releaser. We show here that CORM-A1 under a late prophylactic regime is able to significantly ameliorate the natural course of experimental autoimmune uveoretinitis, a rodent model of immunoinflammatory posterior uveitis. The present study strongly supports the development of CORM-A1 as a potential new drug for treatment of patients with non-infectious posterior uveitis.
authors.affiliation: Dept. of Bio-medical Sciences, University of Catania, Catania, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fagone
authors.affiliation: Dept. of Bio-medical Sciences, University of Catania, Catania, Italy.
authors.forename: Katia
authors.initials: K
authors.lastname: Mangano
authors.affiliation: Dept. of Bio-medical Sciences, University of Catania, Catania, Italy.
authors.forename: Santa
authors.initials: S
authors.lastname: Mammana
authors.affiliation: Dept. of Bio-medical Sciences, University of Catania, Catania, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Cavalli
authors.affiliation: Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Marco
authors.affiliation: Department of Drug Science, Section of Biochemistry, University of Catania, Catania, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Barcellona
authors.affiliation: Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology, University of Catania, Catania, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Salvatorelli
authors.affiliation: Department G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology, University of Catania, Catania, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Magro
authors.affiliation: Dept. of Bio-medical Sciences, University of Catania, Catania, Italy. Electronic address: ferdinic@unict.it.
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D001880:Boranes / Q000494:pharmacology*; D002254:Carbonates / Q000494:pharmacology*; D016207:Cytokines / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D010446:Peptide Fragments / Q000633:toxicity; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D012173:Retinitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D012177:Retinol-Binding Proteins / Q000633:toxicity; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology; D014602:Uvea / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014605:Uveitis / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology
chemical_list: D001880:Boranes; D002254:Carbonates; D016207:Cytokines; D010446:Peptide Fragments; D012333:RNA, Messenger; D012177:Retinol-Binding Proteins; C084432:immunodominant R16 protein, rat; C503854:sodium boranocarbonate
keywords: CORM-A1; Carbon monoxide; EAU; Non-infectious uveitis