title: Improved survival in liver transplant recipients receiving prolonged-release tacrolimus in the European Liver Transplant Registry.
abstract: This study was a retrospective analysis of the European Liver Transplant Registry (ELTR) performed to compare long-term outcomes with prolonged-release tacrolimus versus tacrolimus BD in liver transplantation (January 2008-December 2012). Clinical efficacy measures included univariate and multivariate analyses of risk factors influencing graft and patient survival at 3 years posttransplant. Efficacy measures were repeated using propensity score-matching for baseline demographics. Patients with <1 month of follow-up were excluded from the analyses. In total, 4367 patients (prolonged-release tacrolimus: n = 528; BD: n = 3839) from 21 European centers were included. Tacrolimus BD treatment was significantly associated with inferior graft (risk ratio: 1.81; p = 0.001) and patient survival (risk ratio: 1.72; p = 0.004) in multivariate analyses. Similar analyses performed on the propensity score-matched patients confirmed the significant survival advantages observed in the prolonged-release tacrolimus- versus tacrolimus BD-treated group. This large retrospective analysis from the ELTR identified significant improvements in long-term graft and patient survival in patients treated with prolonged-release tacrolimus versus tacrolimus BD in primary liver transplant recipients over 3 years of treatment. However, as with any retrospective registry evaluation, there are a number of limitations that should be considered when interpreting these data.
authors.affiliation: Hepato-Biliary Center, AP-HP Paul Brousse Hospital, University of Paris-Sud, Inserm U 776, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Adam
authors.forename: V
authors.initials: V
authors.lastname: Karam
authors.forename: V
authors.initials: V
authors.lastname: Delvart
authors.forename: P
authors.initials: P
authors.lastname: Trunečka
authors.forename: D
authors.initials: D
authors.lastname: Samuel
authors.forename: W O
authors.initials: WO
authors.lastname: Bechstein
authors.forename: P
authors.initials: P
authors.lastname: Němec
authors.forename: G
authors.initials: G
authors.lastname: Tisone
authors.forename: J
authors.initials: J
authors.lastname: Klempnauer
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: O O
authors.initials: OO
authors.lastname: Rummo
authors.forename: S
authors.initials: S
authors.lastname: Dokmak
authors.forename: M
authors.initials: M
authors.lastname: Krawczyk
authors.forename: J
authors.initials: J
authors.lastname: Pratschke
authors.forename: O
authors.initials: O
authors.lastname: Kollmar
authors.forename: K
authors.initials: K
authors.lastname: Boudjema
authors.forename: M
authors.initials: M
authors.lastname: Colledan
authors.forename: B G
authors.initials: BG
authors.lastname: Ericzon
authors.forename: G
authors.initials: G
authors.lastname: Mantion
authors.forename: U
authors.initials: U
authors.lastname: Baccarani
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: A
authors.initials: A
authors.lastname: Paul
authors.forename: P
authors.initials: P
authors.lastname: Bachellier
authors.forename: F
authors.initials: F
authors.lastname: Zamboni
authors.forename: R
authors.initials: R
authors.lastname: Hanvesakul
authors.forename: P
authors.initials: P
authors.lastname: Muiesan
mesh_terms: D000328:Adult; D000368:Aged; D005060:Europe; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D053208:Kaplan-Meier Estimate; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D016559:Tacrolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus