title: Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study.
abstract: OBJECTIVE
  There are no established chemical biomarkers of idiopathic Parkinson's disease (PD). The results of a prior metabolomics-based biomarker study suggested that near-infrared spectroscopy of blood plasma samples may distinguish idiopathic PD from neurologically normal controls.
  
  
  METHODS
  Near-infrared spectroscopy was used to detect and quantify substrate modifications in blood plasma samples derived from 71 PD subjects enrolled in the PostCEPT observational study and 68 normal control subjects.
  
  
  RESULTS
  Near-infrared spectra values were significantly higher in the PD group compared with the control group when adjusted for age and gender (PD: adjusted mean 0.49 [95% CI: 0.45-0.53]; control: adjusted mean 0.40 [95% CI: 0.36-0.44]; p = 0.004, multiple regression).
  
  
  CONCLUSIONS
  Near-infrared spectra of blood plasma in early-stage idiopathic PD differ from those of non-neurological control subjects. However, the degree of overlap between the groups limits the use of this technique in its present form as a PD biomarker for routine clinical practice.
authors.affiliation: Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Bernard
authors.initials: B
authors.lastname: Ravina
authors.forename: Shirley
authors.initials: S
authors.lastname: Eberly
authors.forename: David
authors.initials: D
authors.lastname: Oakes
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
authors.forename: Vince
authors.initials: V
authors.lastname: Dodelet
authors.forename: Pieter
authors.initials: P
authors.lastname: Roos
authors.forename: Jennifer
authors.initials: J
authors.lastname: Harman
authors.forename: Ira
authors.initials: I
authors.lastname: Shoulson
authors.forename: Hyman M
authors.initials: HM
authors.lastname: Schipper
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D015415:Biomarkers
keywords: Parkinson's disease; biomarker; diagnosis; near-infrared spectroscopy; oxidative stress; plasma