title: The mitochondrial tRNA(Gln) T4353C mutation may not be associated with essential hypertension in Han Chinese population.
abstract: We reported here the possible role of a mitochondrial tRNA mutation: T4353C in clinical expression of essential hypertension in Chinese population. The human mammalian mitochondrial tRNA database was used to analyze the conservation index of this mutation between different species. Moreover, phylogenetic analysis showed that the T4353C mutation belonged to human mitochondrial haplogroup HV, a West Eurasian haplogroup found throughout Western Asia and Eastern European but was infrequent in China. In addition, structural prediction of the T4353C mutation indicated that this transition did not alter the secondary structure of tRNA(Gln). Together, our data indicated that the T4353C mutation occurred infrequent and may not be associated with essential hypertension in Han Chinese population.
authors.affiliation: a Department of Emergency , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Meng
authors.affiliation: a Department of Emergency , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Pei
authors.affiliation: a Department of Emergency , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , P.R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lan
mesh_terms: D044466:Asian People; D002681:China; D000075222:Essential Hypertension; D054629:Genome, Mitochondrial; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D000072741:Maternal Inheritance; D009154:Mutation; D010375:Pedigree; D010802:Phylogeny; D012343:RNA, Transfer; D012351:RNA, Transfer, Gln
chemical_list: D012351:RNA, Transfer, Gln; D012343:RNA, Transfer
keywords: Haplogroup; T4353C mutation; mitochondrial tRNAGln