title: The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model.
abstract: OBJECTIVE
  To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats.
  
  
  METHODS
  Neuropathy was induced in Sprague-Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment.
  
  
  RESULTS
  Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose.
  
  
  CONCLUSIONS
  Thioctic acid may be an effective treatment for vincristine-induced neuropathy.
authors.affiliation: Department of Laboratory Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea.
authors.forename: Jimin
authors.initials: J
authors.lastname: Kahng
authors.affiliation: Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea.
authors.forename: Tae Kwan
authors.initials: TK
authors.lastname: Kim
authors.affiliation: Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea.
authors.forename: Eun Yong
authors.initials: EY
authors.lastname: Chung
authors.affiliation: Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea knabi_2000@naver.com.
authors.forename: Yee Suk
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Department of Anaesthesia and Pain Medicine, Bucheon St Mary's Hospital, The Catholic University of Korea, Bucheon, Republic of Korea.
authors.forename: Jeong Yeon
authors.initials: JY
authors.lastname: Moon
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D009437:Neuralgia / Q000188:drug therapy; D010147:Pain Measurement; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D008063:Thioctic Acid / Q000627:therapeutic use*; D014750:Vincristine / Q000009:adverse effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D014750:Vincristine; D008063:Thioctic Acid
keywords: Thioctic acid; neuropathy; pain; vincristine