title: [Pulmonary hypertension due to left heart diseases].
abstract: Pulmonary hypertension (PH), a common complication of left heart diseases (LHD), negatively impacts symptoms, exercise capacity, and outcome. Although the true prevalence of PH-LHD is unknown, a subset of patients might present significant PH that cannot be explained by a passive increase in left-sided filling pressures. The term "out-of-proportion" PH has been used to identify that population without a clear definition, which has been found less than ideal and created confusion. We propose a change in terminology and a new definition of PH due to LHD. We suggest to abandon "out-of-proportion" PH and to distinguish "isolated post-capillary PH" from "post-capillary PH with a pre-capillary component" on the basis of the pressure difference between diastolic pulmonary artery pressure and pulmonary artery wedge pressure. Although there is no validated treatment for PH-LHD, we provide insights into management and discuss completed and randomized trials in this condition. Finally, we provide recommendations for future clinical trials to establish safety and efficacy of novel compounds to target this area of unmet medical need. (J Am Coll Cardiol 2013;62:D100-8) ©2013 by the American College of Cardiology Foundation.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vachiéry
authors.forename: Yochai
authors.initials: Y
authors.lastname: Adir
authors.forename: Joan Albert
authors.initials: JA
authors.lastname: Barberà
authors.forename: Hunter
authors.initials: H
authors.lastname: Champion
authors.forename: John Gerard
authors.initials: JG
authors.lastname: Coghlan
authors.forename: Vincent
authors.initials: V
authors.lastname: Cottin
authors.forename: Teresa
authors.initials: T
authors.lastname: De Marco
authors.forename: Nazzareno
authors.initials: N
authors.lastname: Galiè
authors.forename: Stefano
authors.initials: S
authors.lastname: Ghio
authors.forename: J Simon R
authors.initials: JS
authors.lastname: Gibbs
authors.forename: Fernando
authors.initials: F
authors.lastname: Martinez
authors.forename: Marc
authors.initials: M
authors.lastname: Semigran
authors.forename: Gerald
authors.initials: G
authors.lastname: Simonneau
authors.forename: Athol
authors.initials: A
authors.lastname: Wells
authors.forename: Werner
authors.initials: W
authors.lastname: Seeger