title: Hepatoprotective effects of polysaccharides extracted from Zizyphus jujube cv. Huanghetanzao.
abstract: Jujube polysaccharides have been proved to have various bioactivities. This study was designed to evaluate the chemical composition and hepatoprotective function of the polysaccharides extracted from Zizyphus jujube cv. Huanghetanzao (HJP). The composition of HJP was determined as heteropolysaccharides with galactose and arabinose being the main components. The pretreatment of mice with HJP significantly (p<0.01) reduced the activities of serum hepatic AST, ALT, and LDH induced by CCl4 or acetaminophen (APAP) while the commercial liver-injury treatment drug silybin did not show any prevention effects. Mechanistic study results indicate that the administration of the CCl4- or APAP-injured mice with HJP enhanced SOD and GSH-Px and decreased MDA, indicating that anti-oxidation and detoxification could be the pathways for the liver protection observed. In addition, the liver prevention and treatment effects of HJP on the liver damage induced by CCl4 or APAP obtained from the liver enzyme analyses were confirmed by the hepatic histopathology studies in mice. Therefore, HJP could be used as a prevention and treatment agent for liver injury induced by liver toxic chemicals and drugs.
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Guangpu
authors.initials: G
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Xinquan
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhang
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Wei
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Yongjie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China.
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.affiliation: Medical Research Center, Shandong Provisional Qianfoshan Hospital, 16766 Jishi Road, Jinan 250014, China. Electronic address: chenghuiling2006@163.com.
authors.forename: Huiling
authors.initials: H
authors.lastname: Cheng
authors.affiliation: School of Pharmaceutical Sciences and Center for Pharmaceutical Research & Drug Delivery Systems, Shandong University, 44 West Wenhua Road, Jinan 250012, China. Electronic address: zxzhao@sdu.edu.cn.
authors.forename: Zhongxi
authors.initials: Z
authors.lastname: Zhao
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D008111:Liver Function Tests; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D031957:Ziziphus / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D011134:Polysaccharides; D020011:Protective Agents
keywords: Hepatoprotective effects; Polysaccharides; Zizyphus jujube cv. Huanghetanzao