title: Ocular complications in children after hematopoietic stem cell transplantation without total body irradiation.
abstract: OBJECTIVE
  The purpose of the study was to evaluate whether hematopoietic stem cell transplantation (HSCT) without conditioning Total Body Irradiation (TBI) had lower or milder ocular complication rates in the pediatric population.
  
  
  METHODS
  This study included all children who underwent HSCT without conditioning TBI at the Chaim Sheba Medical Center between the years 2001 and 2008. All children had an ophthalmic evaluation prior to and every four months after HSCT.
  
  
  RESULTS
  Of the 33 children who initially comprised this study, ten did not complete the minimal follow-up of four months, and were, thus, excluded from the study. Follow-up of the remaining 23 children ranged from four to 117 months. Dry eye related to chronic graft-versus-host disease (cGVHD) developed in eight children (35 %). In three cases, an additional complication was observed : corneal abscess, herpes zoster ophthalmicus, and bilateral subcapsular cataract (one case each). Posterior segment or neuro-ophthalmological complications were not observed in any patient.
  
  
  CONCLUSIONS
  In our study group, the preclusion of conditioning TBI before HSCT did not result in a decreased ocular complication rate compared to past publications, but complications were relatively mild and confined only to the anterior segment.
authors.affiliation: Neuro-Ophthalmology Unit, The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel, mkinori@hotmail.com.
authors.forename: Michael
authors.initials: M
authors.lastname: Kinori
authors.forename: Bella
authors.initials: B
authors.lastname: Bielorai
authors.forename: Daniel
authors.initials: D
authors.lastname: Souroujon
authors.forename: Dafna
authors.initials: D
authors.lastname: Hutt
authors.forename: Iris
authors.initials: I
authors.lastname: Ben-Bassat Mizrachi
authors.forename: Ruth
authors.initials: R
authors.lastname: Huna-Baron
mesh_terms: D000038:Abscess / Q000209:etiology; D000293:Adolescent; D002386:Cataract / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003316:Corneal Diseases / Q000209:etiology; D015352:Dry Eye Syndromes / Q000209:etiology; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006563:Herpes Zoster Ophthalmicus / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation