title: [Organoprotective effects of the combination of perindopril and amlodipine depending on the renal functional state in patients with arterial hypertension].
abstract: OBJECTIVE
  To estimate effect of combined perindopril/amlodipine therapy on structural and functional characteristics of the heart and blood vessels, intrarenal hemodynamics in patients with essential arterial hypertension (AH) depending on the degree of renal dysfunction.
  
  
  METHODS
  112 patients (63 men and 49 women) were included in the study; 35 of them (group 1) had the glomerular filtration rate (GFR) 90 ml/min/1.73 m2 or higher, 43 (group 2)--60-89 ml/min/1.73 m2 and 34 (group 3)--9-45 ml/min/i1.7 mi. The patients were treated with a fixed combination of dosage forms ofp erindopril and amlodipine at 10/5 mg/days or 10/10 mg/days for 24 weeks.
  
  
  RESULTS
  Pronounced antihypertensive effect of therapy was comparable in all groups. However dynamics of structural and functional indicators of the left ventricle (LV) and a brachial artery was apparent only in group 3. Endothelium-dependent vasodilation, cardiac index and LV ejectionf raction increased significantly whereas myocardiumnmass index of L decreased .A reduction of resistance andpulsation indices was recorded in interlobar renal arteries especially in groups 2 and 3. Serunmcreatinine level and urinary albumin excretion were significantly decreased while GFR increased .
  
  
  CONCLUSIONS
  Manifestations ofr emodeling ofc ardiovascular system and protective efficiencvyof the fixed combination ofp erin.opril and amlodipine correlate with the degree ofr enal dysfunction.
authors.forename: B G
authors.initials: BG
authors.lastname: Iskenderov
authors.forename: Z M
authors.initials: ZM
authors.lastname: Budagovskaia
authors.forename: O N
authors.initials: ON
authors.lastname: Sisina
mesh_terms: D017311:Amlodipine / Q000008:administration & dosage / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; C542336:amlodipine, perindopril drug combination; D017311:Amlodipine; D020913:Perindopril