title: Association of human fetuin-A rs4917 polymorphism with obesity in 2 cohorts.
abstract: BACKGROUND
  Previous studies have shown association of the multifunctional hepatic protein α2HS-glycoprotein/human fetuin A with insulin resistance, type 2 diabetes mellitus, metabolic syndrome, obesity, and atherosclerosis. Reports of contribution of α2HS-glycoprotein/human fetuin A rs4917 single-nucleotide polymorphism to the development of these pathologic processes are inconsistent. We aimed to investigate the association between variants of rs4917 and parameters of obesity, lipid status, the proinflammatory cytokine tumor necrosis factor α (TNF-α), adipokines (adiponectin, resistin), and insulin resistance in 2 cohorts.
  
  
  METHODS
  Eighty-one healthy persons (cohort 1) and 157 patients with previous myocardial infarction (cohort 2) were included in this cross-sectional study. rs4917 Polymorphism was determined by the allele-specific KASP by design genotyping assays.
  
  
  RESULTS
  In cohort 1, T-nucleotide carriers had lower low-density lipoprotein cholesterol levels compared with non-T carriers. The serum concentration of TNF-α was found to be higher carrying the non-T allele in cohort 1; however, this difference was not observed in cohort 2. In cohort 2, T carriers had lower body mass index and abdominal and waist circumferences than did non-T carriers. The T nucleotide was more frequent in nonobese than in obese patients (χ = 5.217, P = 0.022). Nonobese, nondiabetic T carriers still had lower body mass index and waist circumference than did non-T carriers.
  
  
  CONCLUSIONS
  Our data suggest that the T nucleotide in rs4917 is associated with more favorable lipid status among healthy persons (i.e., lower low-density lipoprotein cholesterol) and anthropologic parameters of obesity in cohort 2. The protective role of the T allele may also be associated with lower TNF-α levels found in healthy individuals.
authors.affiliation: From the *3rd Department of Internal Medicine and †Department of Family Medicine, Semmelweis University, ‡Károlyi Sándor Municipal Hospital; §Atherosclerosis Research Group of Hungarian Academy of Sciences; and Departments of ∥Genetics and Immunology, and Cell Sciences and ¶Public Health, Semmelweis University, Budapest, Hungary.
authors.forename: György
authors.initials: G
authors.lastname: Temesszentandrási
authors.forename: Krisztián
authors.initials: K
authors.lastname: Vörös
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Böröcz
authors.forename: Edit
authors.initials: E
authors.lastname: Kaszás
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.forename: András
authors.initials: A
authors.lastname: Falus
authors.forename: Károly
authors.initials: K
authors.lastname: Cseh
authors.forename: László
authors.initials: L
authors.lastname: Kalabay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D060749:alpha-2-HS-Glycoprotein / Q000235:genetics*
chemical_list: C556354:AHSG protein, human; D060749:alpha-2-HS-Glycoprotein