title: [Pleiotropic effects of atorvastatin and dynamics of quality of life characteristics in patients with hypertensive disease and metabolic syndrome].
abstract: OBJECTIVE
  To study pleiotropic effects of atorvastatin during 8-week therapy of metabolic syndrome and estimate their relationship with dynamics of quality of life characteristics (QLC).
  
  
  METHODS
  This 8-week study included 36 patients with stage II hypertensive disease associated with metabolic syndrome (MS). Comprehensive clinical, laboratory and instrumental examination was supplemented by QLC assessment using the MOS SF-36 questionnaire.
  
  
  RESULTS
  8-week therapy of stage II hypertensive disease associated with metabolic syndrome using individually selected doses of atorvastatin (20 to 40 mg/d) significantly reduced atherogenic cholesterol fraction and serum leptin levels; it had positive effect on carbohydrate and purine metabolism and safely maintained positive dynamics of subjective assessment of most points of the MOS SF-36 questionnaire.
authors.forename: I D
authors.initials: ID
authors.lastname: Bespalova
authors.forename: V V
authors.initials: VV
authors.lastname: Kaliuzhin
authors.forename: N V
authors.initials: NV
authors.lastname: Riazantseva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Mediantsev
authors.forename: I A
authors.initials: IA
authors.lastname: Osikhov
authors.forename: B Iu
authors.initials: BIu
authors.lastname: Murashev
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000069059:Atorvastatin; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D024821:Metabolic Syndrome / Q000188:drug therapy*; D008875:Middle Aged; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin