title: A new path to leukemia with WIT.
abstract: In this issue, Wang et al., 2015 describes that WT1 recruits TET2 to the DNA, an important feature of a new regulatory pathway linked to the development of acute myeloid leukemia (AML). This pathway consists of WT1, IDH1/2, and TET2 (WIT) genes, with exclusive mutations of the three genes inducing myeloid cell proliferation.
authors.affiliation: Center for Genomic Regulation, C/Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain; Pompeu Fabra University, Plaça de la Mercè, 10, 08002 Barcelona, Spain. Electronic address: joseluis.sardina@crg.eu.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Sardina
authors.affiliation: Center for Genomic Regulation, C/Dr. Aiguader, 88, PRBB Building, 08003 Barcelona, Spain; Pompeu Fabra University, Plaça de la Mercè, 10, 08002 Barcelona, Spain. Electronic address: thomas.graf@crg.eu.
authors.forename: Thomas
authors.initials: T
authors.lastname: Graf
mesh_terms: D004268:DNA-Binding Proteins / Q000502:physiology*; D049308:Dioxygenases; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D025721:WT1 Proteins / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D025721:WT1 Proteins; C583751:WT1 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human