title: Key emerging issues in progressive supranuclear palsy and corticobasal degeneration.
abstract: It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that both are associated with tau. Recent advances over the past 3 years that are notable to the field are discussed in this review that covers clinical diagnosis, pathological features, neuroimaging and CSF biomarkers, genetic associations and clinical trials related to progressive supranuclear palsy and corticobasal degeneration.
authors.affiliation: Behavioural Neurology and Movement Disorders, Mayo Clinic, Rochester, MN, 55905, USA, josephs.keith@mayo.edu.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D001479:Basal Ganglia / Q000473:pathology*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D027682:Cation Transport Proteins / Q000235:genetics; D002540:Cerebral Cortex / Q000473:pathology*; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D024101:Mitochondrial Proteins / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology*; D059906:Neuroimaging; D013494:Supranuclear Palsy, Progressive / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology*; D014157:Transcription Factors / Q000235:genetics; D016875:tau Proteins / Q000235:genetics
chemical_list: D015415:Biomarkers; D027682:Cation Transport Proteins; D018398:Homeodomain Proteins; C054369:MAPT protein, human; C430096:MRS2 protein, human; D024101:Mitochondrial Proteins; D014157:Transcription Factors; C476826:ZHX2 protein, human; D016875:tau Proteins