title: Incidence and overall survival of malignant ameloblastoma.
abstract: BACKGROUND
  Malignant ameloblastoma, comprising metastasizing ameloblastoma and ameloblastic carcinoma, represents 1.6-2.2% of all odontogenic tumors. Due to its rare nature, malignant ameloblastoma has only been reported in the literature in small case series or case reports. Using the Surveillance, Epidemiology and End-Results (SEER) database, we have performed a population-based study to determine the incidence rate and the absolute survival of malignant ameloblastoma.
  
  
  METHODS
  Using the International Classification of Diseases for Oncology (ICD-O) codes 9310/3 and 9270/3, data from the SEER database were used to calculate the incidence rate and absolute survival rate of population with malignant ameloblastoma.
  
  
  RESULTS
  The overall incidence rate of malignant ameloblastoma was 1.79 per 10 million person/year. The incidence rate was higher in males than females and also higher in black versus white population. The median overall survival was 17.6 years from the time of diagnosis and increasing age was associated with a statistically significant poorer survival.
  
  
  CONCLUSIONS
  To our best knowledge, we report the largest population-based series of malignant ameloblastoma. The incidence rate was 1.79 per 10 million person/year and the overall survival was 17.6 years.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rizzitelli
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia; Department of Surgery, Monash University, Level 5, E Block, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia.
authors.forename: Nicolas R
authors.initials: NR
authors.lastname: Smoll
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia; Department of Surgery, Monash University, Level 5, E Block, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Chae
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia; Department of Surgery, Monash University, Level 5, E Block, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia; Department of Surgery, School of Medicine and Dentistry, James Cook University Clinical School, Level 1, Townsville Hospital, 100 Angus Smith Drive, Douglas, Townsville Queensland 4814, Australia.
authors.forename: Warren M
authors.initials: WM
authors.lastname: Rozen
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frankston Hospital, Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia; Department of Surgery, Monash University, Level 5, E Block, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia; Monash University Plastic and Reconstructive Surgery Unit (Peninsula Clinical School), Peninsula Health, 2 Hastings Road, Frankston, Victoria 3199, Australia.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hunter-Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000453:epidemiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016208:Databases, Factual; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007573:Jaw Neoplasms / Q000453:epidemiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D055815:Young Adult