title: Current proceedings of cerebral palsy.
abstract: Cerebral palsy (CP) is a complicated disease with varying causes and outcomes. It has created significant burden to both affected families and societies, not to mention the quality of life of the patients themselves. There is no cure for the disease; therefore, development of effective therapeutic strategies is in great demand. Recent advances in regenerative medicine suggest that the transplantation of stem cells, including embryonic stem cells, neural stem cells, bone marrow mesenchymal stem cells, induced pluripotent stem cells, umbilical cord blood cells, and human embryonic germ cells, focusing on the root of the problem, may provide the possibility of developing a complete cure in treating CP. However, safety is the first factor to be considered because some stem cells may cause tumorigenesis. Additionally, more preclinical and clinical studies are needed to determine the type of cells, route of delivery, cell dose, timing of transplantation, and combinatorial strategies to achieve an optimal outcome.
authors.affiliation: Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Hueng-Chuen
authors.initials: HC
authors.lastname: Fan
authors.forename: Li-Ing
authors.initials: LI
authors.lastname: Ho
authors.forename: Ching-Shiang
authors.initials: CS
authors.lastname: Chi
authors.forename: Shin-Nan
authors.initials: SN
authors.lastname: Cheng
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Juan
authors.forename: Kuo-Liang
authors.initials: KL
authors.lastname: Chiang
authors.forename: Shinn-Zong
authors.initials: SZ
authors.lastname: Lin
authors.forename: Horng-Jyh
authors.initials: HJ
authors.lastname: Harn
mesh_terms: D000818:Animals; D002547:Cerebral Palsy / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D002986:Clinical Trials as Topic; D036101:Cord Blood Stem Cell Transplantation; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation; D045164:Mesenchymal Stem Cell Transplantation; D058953:Neural Stem Cells / Q000166:cytology / Q000637:transplantation; D012307:Risk Factors