title: Biotechnological conversion of glycerol from biofuels to 1,3-propanediol using Escherichia coli.
abstract: In the face of shortage of fossil fuel supplies and climate warming triggered by excessive carbon dioxide emission, alternative resources for chemical industry have gained considerable attention. Renewable resources and their derivatives are of particular interest. Glycerol, which constitutes one of the by-products during biodiesel production, is such a substrate. Thus, generated excess glycerol may become an environmental problem, since it cannot be disposed of in the environment. The most promising products obtained from glycerol are polyols, including 1,3-propanediol, an important substrate in the production of synthetic materials, e.g. polyurethanes, unsaturated polyesters, and epoxy resins. Glycerol can be used as a carbon and energy source for microbial growth in industrial microbiology to produce 1,3-propanediol. This paper is a review of metabolic pathways of native producers and E. coli with the acquired ability to produce the diol via genetic manipulations. Culture conditions during 1,3-PDO production and genetic modifications of E. coli used in order to increase efficiency of glycerol bioconversion are also described in this paper.
authors.affiliation: Poznan University of Life Sciences, Department of Biochemistry and Biotechnology, Poznań, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Przystałowska
authors.affiliation: Poznan University of Life Sciences, Department of Biochemistry and Biotechnology; Polish Academy of Sciences, Institute of Human Genetics, Poznań, Poland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lipiński
authors.affiliation: Poznan University of Life Sciences, Department of Biochemistry and Biotechnology; Polish Academy of Sciences, Institute of Human Genetics, Poznań, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Słomski
mesh_terms: D056804:Biofuels; D001709:Biotechnology; D004926:Escherichia coli / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D011409:Propylene Glycols / Q000378:metabolism*
chemical_list: D056804:Biofuels; D011409:Propylene Glycols; C041787:1,3-propanediol; D005990:Glycerol