title: A case of prolidase deficiency accompanying leg ulcers.
abstract: Prolidase deficiency (PD) is a rare autosomal recessive disorder that has symptoms such as skin ulcers, characteristic facies, mental retardation, skeletal deformities, hematological anomalies, splenomegaly, and chronic infections. Deficiency of prolidase leads to the increased excretion of proline in urine, which causes impaired collagen synthesis and delay in wound healing. This case reports a 40-year-old female who has had cutaneous ulcers since the age of 7 years. We also recognized borderline intellectual functioning as well as hematologic abnormalities and splenomegaly. We present this rare case to draw attention to consider prolidase deficiency in the differential diagnosis of leg ulcers.
authors.affiliation: Sakarya University, School of Medicine, Sakarya, Turkey drbernakilic@yahoo.com.
authors.forename: Berna
authors.initials: B
authors.lastname: Solak
authors.affiliation: Sakarya University Training and Research Hospital, Sakarya, Turkey.
authors.forename: Rabia Oztas
authors.initials: RO
authors.lastname: Kara
authors.affiliation: Sakarya University, School of Medicine, Sakarya, Turkey.
authors.forename: Teoman
authors.initials: T
authors.lastname: Erdem
authors.affiliation: Haydarpasa Hospital of Gülhane Military Medical Academy, Istanbul, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Muftuoglu
mesh_terms: D000328:Adult; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000150:complications* / Q000201:enzymology; D056732:Prolidase Deficiency / Q000150:complications* / Q000201:enzymology; D014945:Wound Healing
chemical_list: D004150:Dipeptidases; C022449:proline dipeptidase
keywords: hydrocolloid gel; leg ulcer; prolidase deficiency