title: Safety and efficacy of intravenous colistin in children.
abstract: OBJECTIVE
  To observe the safety and efficacy of Colistimethate sodium in children infected with gram-negative bacteria, susceptible only to colistimethate sodium.
  
  
  METHODS
  This prospective observational study done over 2 years observed children who received colistin for >48 h, for renal failure as defined by p-RIFLE criteria.
  
  
  RESULTS
  Out of 68 children, 52 (76.5%) survived. There were three children with evidence of acute kidney injury and none had neurotoxicity. Serum creatinine significantly decreased at 48 h and at end of treatment, from that at beginning of therapy (P=0.007).
  
  
  CONCLUSIONS
  Colistimethate sodium is effective against carbapenem-resistant Gram-negative bacteria, and is safe in children.
authors.affiliation: Department of Intensive Care, Rainbow Childrens Hospital, Banjara Hills, Hyderabad, India. Correspondence to: Dr P Preetham Kumar C/o Rainbow Childrens Hospital, Banjara Hills, Hyderabad. 500034. drpreethamp@gmail.com.
authors.forename: Poddutoor Preetham
authors.initials: PP
authors.lastname: Kumar
authors.forename: Swapnil Rameshwar
authors.initials: SR
authors.lastname: Giri
authors.forename: Farhan A R
authors.initials: FA
authors.lastname: Shaikh
authors.forename: Nalinikant
authors.initials: N
authors.lastname: Panigrahy
authors.forename: Dinesh
authors.initials: D
authors.lastname: Chirla
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000453:epidemiology*; D061605:Administration, Intravenous; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003404:Creatinine; C004691:colistinmethanesulfonic acid; D003091:Colistin