title: Cycloartane Glycosides from the Roots ofCimicifuga foetidawith Wnt Signaling Pathway Inhibitory Activity.
abstract: Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2'-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2',12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5-8) were isolated from the roots ofCimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds7and8showed significant Wnt signaling pathway inhibitory activity, with IC50values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Di-Fan
authors.initials: DF
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Guo-Lei
authors.initials: GL
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Kong
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Ni-Man
authors.initials: NM
authors.lastname: Bao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Nian
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
keywords: 9,19-Cycloartane triterpenoids; Cimicifuga foetida; Cimilactone-type; Luciferase activity; Wnt signal pathway