title: [Role intramural ganglion airway on action of histamine].
abstract: Influence of low concentration histamine on reactivity isolated trachea and bronchus preparations of rat induced field stimulation were studied. Application of 0.01-10 mkg histamine decreased responses preparation of trachea to 83% and bronchus to 79% at smooth muscle stimulation dose-depended manner. At postganglionic nerves stimulation histamine potentiated contraction of trachea without ganglions to 123%, trachea with ganglions to 110% and decreased contraction of bronchus to 87%. At stimulation ofpreganglionic nerves histamine evoked insignificant changes of contraction. With novocaine treatment of preparations histamine decreased responses of trachea by 19-30% at preganglionic stimulation, while responses of bronchus reduced by 8.2% only. Capsaicin treatment potentiated responses of trachea and bronchus on the effect of histamine induced preganglionic stimulation by 12-14%. We conclude that the action of histamine depends on the presence of ganglions and kind of stimulation. Different structures airways have various availability histamine-receptors and it determines the reaction of smooth muscle for histamine.
authors.forename: A N
authors.initials: AN
authors.lastname: Fedin
authors.forename: E N
authors.initials: EN
authors.lastname: Kiver
authors.forename: L E
authors.initials: LE
authors.lastname: Smirnova
authors.forename: V M
authors.initials: VM
authors.lastname: Kirilina
authors.forename: A I
authors.initials: AI
authors.lastname: Krivchenko
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001339:Autonomic Fibers, Preganglionic; D001980:Bronchi / Q000503:physiopathology*; D002211:Capsaicin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D017442:Histamine Agonists / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology*; D011343:Procaine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018689:Sensory System Agents / Q000494:pharmacology; D014132:Trachea / Q000503:physiopathology*
chemical_list: D000779:Anesthetics, Local; D017442:Histamine Agonists; D018689:Sensory System Agents; D011343:Procaine; D006632:Histamine; D002211:Capsaicin