title: Synthesis of 3-aminoBODIPY dyes via copper-catalyzed vicarious nucleophilic substitution of 2-halogeno derivatives.
abstract: 2-Halogeno BODIPYs undergo copper catalysed nucleophilic substitution with alkyl amines and anilines and an amide to give the corresponding 3-aminoBODIPY derivatives. The substrates are readily prepared by the regioselective 2-halogenation of the chemically robust, preformed BODIPYs thus providing an alternative to direct nucleophilic substitution of the corresponding 3-halogenoBODIPYs which requires regioselective 3-halogenation of the more sensitive dipyrromethane intermediate. 2-Halogenation expands the scope of vicarious substitution of BODIPYs to include weaker nitrogen nucleophiles.
authors.affiliation: School of Chemistry, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. julian.knight@ncl.ac.uk.
authors.forename: Julian G
authors.initials: JG
authors.lastname: Knight
authors.forename: Rua B
authors.initials: RB
authors.lastname: Alnoman
authors.forename: Paul G
authors.initials: PG
authors.lastname: Waddell