title: Association of vitiligo and response in patients with  metastatic malignant melanoma on temozolomide.
abstract: Vitiligo-like lesions, although rare, are believed to be a prognostic factor in malignant melanoma. While a predictive role for such lesions was shown with immunomodulatory therapies, this relation was not demonstrated with temozolomide. We present 3 patients with metastatic malignant melanoma who developed vitiligo-like skin lesions accompanying good response to treatment and prolonged survival. Onset of vitiligo-like lesions with temozolomide in metastatic malignant melanoma may predict long-term response for this treatment.
authors.affiliation: Department of Medical Oncology, Van Training and Research Hospital, Van - Turkey.
authors.forename: Ali Murat
authors.initials: AM
authors.lastname: Tatli
authors.forename: Ali Ayberk
authors.initials: AA
authors.lastname: Besen
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kalender
authors.forename: Mukremin
authors.initials: M
authors.lastname: Uysal
authors.forename: Deniz
authors.initials: D
authors.lastname: Aslan
authors.forename: Sema Sezgin
authors.initials: SS
authors.lastname: Goksu
authors.forename: Seyda Gulenay
authors.initials: SG
authors.lastname: Gunduz
authors.forename: Hasan Senol
authors.initials: HS
authors.lastname: Coskun
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects; D001943:Breast Neoplasms / Q000188:drug therapy; D003606:Dacarbazine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018450:Disease Progression; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005528:Foot; D006257:Head; D006801:Humans; D007044:Hysterectomy; D033162:Incidental Findings; D017093:Liver Failure / Q000209:etiology; D008113:Liver Neoplasms / Q000150:complications / Q000556:secondary*; D008297:Male; D008545:Melanoma / Q000175:diagnosis* / Q000188:drug therapy* / Q000556:secondary; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011351:Proctoscopy; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects; D000077204:Temozolomide; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014820:Vitiligo / Q000139:chemically induced*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D003606:Dacarbazine; D000077204:Temozolomide