title: [Hepatoprotective activity of betulonic acid amides containing a piperidine or pyrrolidine nitroxide moiety].
abstract: Betulonic acid amides containing a nitroxyl radical moiety possess antiholestatic effects in mice. Introduction ofpiperidine nitroxide moiety into lupan core increases its hepatoprotective activity. Oral administration of piperidine nitroxide derivative in dose 50 mg/kg doesn't stimulate transplanted tumor growth and raises a lifespan of mice.
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: D S
authors.initials: DS
authors.lastname: Baev
authors.forename: N A
authors.initials: NA
authors.lastname: Zhukova
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: A N
authors.initials: AN
authors.lastname: Antimonova
authors.forename: N I
authors.initials: NI
authors.lastname: Petrenko
authors.forename: E E
authors.initials: EE
authors.lastname: Shul'ts
authors.forename: I A
authors.initials: IA
authors.lastname: Grigor'ev
mesh_terms: D000577:Amides / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D006505:Hepatitis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D051379:Mice; D009589:Nitrogen Oxides / Q000737:chemistry; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D010880:Piperidines / Q000008:administration & dosage* / Q000737:chemistry; D011759:Pyrrolidines / Q000008:administration & dosage* / Q000737:chemistry; D000094062:Betulinic Acid
chemical_list: D000577:Amides; D009589:Nitrogen Oxides; D009828:Oleanolic Acid; D010880:Piperidines; D011759:Pyrrolidines; C118308:betulonic acid; D000094062:Betulinic Acid; C032727:piperidine; C039900:nitroxyl; C032519:pyrrolidine