title: Tolvaptan in a pediatric patient with diuretic-resistant heart and kidney failure.
abstract: Despite conventional diuretic therapy, volume overload persists in many patients with decompensated heart failure. Adverse effects of diuretics are common, including worsening kidney function and electrolyte disturbance. Furthermore, decreased kidney function also affects the response to diuretics and is associated with an increased risk of mortality. A 10-year-old boy with congestive heart failure (CHF) complicated by advanced chronic kidney disease (CKD) presented with oliguria and generalized edema. He was being treated with furosemide and spironolactone, and these doses were increased to 3 mg/kg/day after admission. Although edema decreased temporarily, the symptoms worsened and furosemide resistance developed 2 months later. Tolvaptan (0.1 mg/kg/day) was started, resulting in a gradual increase in the plasma sodium level and adequate decongestion of the volume overload state. Cardiac function also improved. The use of tolvaptan should be considered in pediatric cases of conventional diuretic-resistant CHF, even when complicated by advanced CKD.
authors.affiliation: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Daishi
authors.initials: D
authors.lastname: Hirano
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kakegawa
authors.forename: Akifumi
authors.initials: A
authors.lastname: Yamada
authors.forename: Akira
authors.initials: A
authors.lastname: Ito
authors.forename: Saori
authors.initials: S
authors.lastname: Miwa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ida
mesh_terms: D065092:Antidiuretic Hormone Receptor Antagonists / Q000008:administration & dosage; D001552:Benzazepines / Q000008:administration & dosage*; D002648:Child; D004232:Diuretics / Q000494:pharmacology*; D004351:Drug Resistance; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000150:complications / Q000188:drug therapy*; D000077602:Tolvaptan
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D004232:Diuretics; D000077602:Tolvaptan
keywords: children; chronic kidney disease; congestive heart failure; furosemide; tolvaptan