title: Oxidative and other posttranslational modifications in extracellular vesicle biology.
abstract: Extracellular vesicles including exosomes, microvesicles and apoptotic vesicles, are phospholipid bilayer surrounded structures secreted by cells universally, in an evolutionarily conserved fashion. Posttranslational modifications such as oxidation, citrullination, phosphorylation and glycosylation play diverse roles in extracellular vesicle biology. Posttranslational modifications orchestrate the biogenesis of extracellular vesicles. The signals extracellular vesicles transmit between cells also often function via modulating posttranslational modifications of target molecules, given that extracellular vesicles are carriers of several active enzymes catalysing posttranslational modifications. Posttranslational modifications of extracellular vesicles can also contribute to disease pathology by e.g. amplifying inflammation, generating neoepitopes or carrying neoepitopes themselves.
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Katalin
authors.initials: K
authors.lastname: Szabó-Taylor
authors.affiliation: University of Oxford, Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, United Kingdom.
authors.forename: Brent
authors.initials: B
authors.lastname: Ryan
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Xabier
authors.initials: X
authors.lastname: Osteikoetxea
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Tamás G
authors.initials: TG
authors.lastname: Szabó
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sódar
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Marcsilla
authors.initials: M
authors.lastname: Holub
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Andrea
authors.initials: A
authors.lastname: Németh
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Krisztina
authors.initials: K
authors.lastname: Pálóczi
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Pállinger
authors.affiliation: University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter EX1 2LU, United Kingdom.
authors.forename: Paul
authors.initials: P
authors.lastname: Winyard
authors.affiliation: Semmelweis University, Department of Genetics, Cell- and Immunobiology, Nagyvárad tér 4, Budapest 1089, Hungary. Electronic address: edit.buzas@gmail.com.
authors.forename: Edit I
authors.initials: EI
authors.lastname: Buzás
mesh_terms: D000818:Animals; D002956:Citrulline / Q000378:metabolism; D000067128:Extracellular Vesicles / Q000737:chemistry / Q000378:metabolism*; D006031:Glycosylation; D006801:Humans; D010084:Oxidation-Reduction; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination
chemical_list: D002956:Citrulline
keywords: Citrullination; Exosome; Extracellular vesicle; Microvesicle; Oxidation; Posttranslational modification