title: Complement in therapy and disease: Regulating the complement system with antibody-based therapeutics.
abstract: Complement is recognized as a key player in a wide range of normal as well as disease-related immune, developmental and homeostatic processes. Knowledge of complement components, structures, interactions, and cross-talk with other biological systems continues to grow and this leads to novel treatments for cancer, infectious, autoimmune- or age-related diseases as well as for preventing transplantation rejection. Antibodies are superbly suited to be developed into therapeutics with appropriate complement stimulatory or inhibitory activity. Here we review the design, development and future of antibody-based drugs that enhance or dampen the complement system.
authors.affiliation: Genmab, Utrecht, The Netherlands.
authors.forename: Joost P M
authors.initials: JP
authors.lastname: Melis
authors.affiliation: Genmab, Utrecht, The Netherlands.
authors.forename: Kristin
authors.initials: K
authors.lastname: Strumane
authors.affiliation: Genmab, Utrecht, The Netherlands.
authors.forename: Sigrid R
authors.initials: SR
authors.lastname: Ruuls
authors.affiliation: Genmab, Utrecht, The Netherlands.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Beurskens
authors.affiliation: Genmab, Utrecht, The Netherlands.
authors.forename: Janine
authors.initials: J
authors.lastname: Schuurman
authors.affiliation: Genmab, Utrecht, The Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: P.Parren@genmab.com.
authors.forename: Paul W H I
authors.initials: PW
authors.lastname: Parren
mesh_terms: D000906:Antibodies / Q000276:immunology* / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy; D003167:Complement Activation / Q000187:drug effects / Q000276:immunology*; D051056:Complement Inactivating Agents / Q000276:immunology* / Q000627:therapeutic use; D003165:Complement System Proteins / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000628:therapy; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology / Q000628:therapy
chemical_list: D000906:Antibodies; D051056:Complement Inactivating Agents; D003165:Complement System Proteins
keywords: Antibody; Antibody engineering; Cancer; Complement; Immunology; Therapy