title: The role of adipocytokines in the pathogenesis of knee joint osteoarthritis.
abstract: Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.
authors.affiliation: Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Richter
authors.forename: Tomasz
authors.initials: T
authors.lastname: Trzeciak
authors.forename: Maciej
authors.initials: M
authors.lastname: Owecki
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pucher
authors.forename: Jacek
authors.initials: J
authors.lastname: Kaczmarczyk
mesh_terms: D054392:Adipokines / Q000378:metabolism / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology; D002358:Cartilage, Articular / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D009765:Obesity / Q000453:epidemiology; D020370:Osteoarthritis, Knee / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D054850:Osteophyte / Q000473:pathology; D012307:Risk Factors; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000378:metabolism
chemical_list: D054392:Adipokines; D016207:Cytokines