title: The high prevalence of hypovitaminosis D in China: a multicenter vitamin D status survey.
abstract: Vitamin D deficiency, which is usually detected by using immunoassays or the more reliable liquid chromatography tandem mass spectrometry (LC-MS/MS) methods, has recently been considered a public health problem worldwide. However, the vitamin D status in Chinese populations, as measured using the LC-MS/MS method, is not available. The objective of this multicenter study was to determine the vitamin D status and prevalence of vitamin D deficiency by using a reliable method in 5 large cities in China. From May 1 to September 31, 2013, we conducted a multicenter study on 2173 apparently healthy adults who were recruited from 5 Chinese cities. The 25-hydroxyvitamin D 25OHD2 and 25OHD3 levels were measured using the LC-MS/MS method. Intact parathyroid hormone (iPTH), calcium, phosphorus, and alkaline phosphate levels were also measured using an automatic analyzer. The mean 25OHD level of all participants was 19.4 ± 6.4 ng/mL (2.5-97.5%: 7.9-32.6 ng/mL), and only 109 (5.0%) participants had a 25OHD2 level >2.5 ng/mL (maximum, 22.4 ng/mL). In this study, the prevalence of severe vitamin D deficiency (<10 ng/mL), vitamin D deficiency (10-20 ng/mL), vitamin D insufficiency (20-30 ng/mL), and vitamin D sufficiency (>30 ng/mL) was 5.9%, 50.0%, 38.7%, and 5.4%, respectively. Women had a significant higher rate of deficiency than men (66.3% vs 45.3%, P < 0.01). Participants aged 18 to 39 years had a lower 25OHD level than elderly individuals (>59 years). Lifestyle may influence the 25OHD level more than the latitude, with participants in Dalian having the highest 25OHD level and the lowest deficiency rate. The serum iPTH level showed a significant negative correlation with the 25OHD level (r = -0.23, P < 0.01) after correcting for age and sex. In conclusion, the present study evaluated the vitamin D status using a reliable method, and our results indicate that vitamin D deficiency is prevalent among all age groups in China, especially among younger adults. We also observed significant differences in the 25OHD levels according to sex, age, and region among apparently healthy individuals.
authors.affiliation: From the Department of Clinical Laboratory (SY, HF, JH, XC, LX, LH, XQ, PL, WS, LQ), Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing; Department of Clinical Laboratory (SL), The First Affiliated Hospital of Dalian Medical University, Dalian; Department of Clinical Laboratory (ML), The First Affiliated Hospital, Sun Yat-sen University, Guangdong; Department of Clinical Laboratory (ZT), The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou; Department of Clinical Laboratory (LW), Xinjiang Medical University, Xinjiang; and Department of Clinical Laboratory (RZ), China-Japan Friendship Hospital, Beijing, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Yu
authors.forename: Huiling
authors.initials: H
authors.lastname: Fang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Han
authors.forename: Xinqi
authors.initials: X
authors.lastname: Cheng
authors.forename: Liangyu
authors.initials: L
authors.lastname: Xia
authors.forename: Shijun
authors.initials: S
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Tao
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Li'an
authors.initials: L
authors.lastname: Hou
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Qin
authors.forename: Pengchang
authors.initials: P
authors.lastname: Li
authors.forename: Ruiping
authors.initials: R
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Su
authors.forename: Ling
authors.initials: L
authors.lastname: Qiu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D002853:Chromatography, Liquid; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D