title: Santorinicele: secretin-enhanced magnetic resonance cholangiopancreatography findings before and after minor papilla sphincterotomy.
abstract: OBJECTIVE
  To evaluate secretin-enhanced MRCP (S-MRCP) findings of patients with pancreas divisum and Santorinicele, before and after minor papilla sphincterotomy.
  
  
  METHODS
  S-MRCP examinations of 519 patients with suspected pancreatic disease were included. Size of the main pancreatic duct, presence and calibre of Santorinicele were evaluated. Duodenal filling was assessed on dynamic images. After sphincterotomy the same parameters and the clinical findings were re-evaluated.
  
  
  RESULTS
  Pancreas divisum was depicted in 55/519 patients (11 %) by MRCP and an additional 26/519 by S-MRCP (total 81/519, 16 %). Santorinicele was detected in 7/81 patients (8.6 %) with pancreas divisum by MRCP and an additional 20/81 by S-MRCP (total 27/81, 33 %). Dorsal duct in patients with Santorinicele was significantly larger in the head compared with patients with only pancreas divisum (p < 0.01), in basal conditions (average 2.4 versus 1.9 mm) and after secretin administration (average 3.0 versus 2.4 mm). Duodenal filling was impaired in 11/27 patients (41 %) with Santorinicele. After sphincterotomy significant reduction in size of Santorinicele (-33 %) and dorsal duct (-17 %), increase of pancreatic juice and symptoms improvement were observed.
  
  
  CONCLUSIONS
  Secretin administration increases the accuracy of MRCP in detecting Santorinicele and demonstrates the impaired duodenal filling. S-MRCP is useful to assess results of sphincterotomy.
  
  
  CONCLUSIONS
  • Secretin-enhanced MRCP gives anatomical and functional information on pancreatic outflow dynamics. • Santorinicele is a cystic dilatation of the termination of the Santorini duct. • S-MRCP images are the most useful to recognize the presence of Santorinicele. • Minor papilla sphincterotomy during ERCP is indicated in patients with Santorinicele.
authors.affiliation: Department of Radiology - Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, Verona, Italy, boninsegnae@gmail.com.
authors.forename: Enrico
authors.initials: E
authors.lastname: Boninsegna
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manfredi
authors.forename: Anna
authors.initials: A
authors.lastname: Ventriglia
authors.forename: Riccardo
authors.initials: R
authors.lastname: Negrelli
authors.forename: Beatrice
authors.initials: B
authors.lastname: Pedrinolla
authors.forename: Sara
authors.initials: S
authors.lastname: Mehrabi
authors.forename: Armando
authors.initials: A
authors.lastname: Gabbrielli
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzi Mucelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D049448:Cholangiopancreatography, Magnetic Resonance / Q000379:methods; D003287:Contrast Media; D004108:Dilatation, Pathologic / Q000473:pathology / Q000601:surgery; D004386:Duodenum / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000002:abnormalities*; D010181:Pancreatic Cyst / Q000473:pathology* / Q000601:surgery; D010183:Pancreatic Ducts / Q000473:pathology; D011182:Postoperative Care; D011300:Preoperative Care; D012633:Secretin; D013105:Sphincterotomy, Transduodenal / Q000379:methods; D055815:Young Adult
chemical_list: D003287:Contrast Media; D012633:Secretin