title: Early-life stress increases the motility of microglia in adulthood.
abstract: Early-life stress may cause several neuropsychological disorders in adulthood. Such disorders may be induced as a result of instability of neuronal circuits and/or synaptic formation. However, the mechanisms underlying such instability have not yet been clearly understood. We previously reported that the mushroom spine in the somatosensory cortex (SSC) is unstable in early-life stressed mice not only in the juvenile stage but also in adulthood. In this study, we measured the number and motility of microglial processes in early-life stressed mice to understand the mechanism further. We found that the number and motility of filopodia-like protrusions of microglial processes tended to increase in the SSC of early-life stressed mice. Interestingly, the motility of protrusions correlated significantly with the nociceptive threshold level measured by the von Frey test. These results indicated that the activity of microglia affected the neuronal function in early-life stressed mice.
authors.affiliation: Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan, takatsur@gunma-u.ac.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takatsuru
authors.forename: Junichi
authors.initials: J
authors.lastname: Nabekura
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kohsaka
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Koibuchi
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D017628:Microglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D013315:Stress, Psychological / Q000503:physiopathology*; D013569:Synapses / Q000502:physiology