title: Age-Period-Cohort approaches to back-calculation of cancer incidence rate.
abstract: A compartment model for cancer incidence and mortality is developed in which healthy subjects may develop cancer and subsequently die of cancer or another cause. In order to adequately represent the experience of a defined population, it is also necessary to allow for subjects who are diagnosed at death, as well as subjects who migrate and are subsequently lost to follow-up. Expressions are derived for the number of cancer deaths as a function of the number of incidence cases and vice versa, which allows for the use of mortality statistics to obtain estimates of incidence using survival information. In addition, the model can be used to obtain estimates of cancer prevalence, which is useful for health care planning. The method is illustrated using data on lung cancer among males in Connecticut.
authors.affiliation: Biostatistics, Department of Population Health, New York University School of Medicine, New York, NY, 10016, U.S.A.
authors.forename: Cheongeun
authors.initials: C
authors.lastname: Oh
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D015331:Cohort Studies; D003237:Connecticut / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D059012:Lost to Follow-Up; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality; D008875:Middle Aged; D015233:Models, Statistical; D015995:Prevalence; D012042:Registries; D016019:Survival Analysis; D014798:Vital Statistics
keywords: age-period-cohort model; back-calculation; incidence; mortality; survival