title: [Pathology diagnostics by human breath analyze].
abstract: Modern medicine experiences deficit of inexpensive rapid screening technologies despite progress in the development of diagnostic methods for various diseases. A promising approach is the analysis of exhaled air known to contain thousands of volatile organic substances whose composition differs considerably in health and disease. We isolated certain compounds that may be used as biomarkers of cardiovascular pathology (nitric oxide, carbon monoxide, pentane, isoprene, acetone). There is a variety of methods for the detection of substances in the exhaled air; such as gas spectrography, mass spectrometry, etc. However, ion mobility spectrometry appears the most suitable technique for the purpose of screening studies due to its high speed and sensitivity, small size of the apparatus, and possibility to measure trace amounts of the substances of interest. Possibilities to diagnose lung cancer based on exhaled air composition are considered.
authors.forename: F Iu
authors.initials: FIu
authors.lastname: Kopylov
authors.forename: A L
authors.initials: AL
authors.lastname: Syrkin
authors.forename: P Sh
authors.initials: PSh
authors.lastname: Chomakhidze
authors.forename: A A
authors.initials: AA
authors.lastname: Bykova
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Shaltaeva
authors.forename: V V
authors.initials: VV
authors.lastname: Beliakov
authors.forename: V S
authors.initials: VS
authors.lastname: Pershenkov
authors.forename: N N
authors.initials: NN
authors.lastname: Samotaev
authors.forename: A V
authors.initials: AV
authors.lastname: Golovin
authors.forename: V K
authors.initials: VK
authors.lastname: Vasil'ev
authors.forename: E K
authors.initials: EK
authors.lastname: Malkin
authors.forename: E A
authors.initials: EA
authors.lastname: Gromov
authors.forename: I A
authors.initials: IA
authors.lastname: Ivanov
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Lipatov
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Iakovlev
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D001944:Breath Tests / Q000295:instrumentation / Q000379:methods*; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*
chemical_list: D015415:Biomarkers