title: [The role of NGF and BDNF in mature brain activity regulation].
abstract: Neurotrophins are associated with the maintenance of optimal functional state of CNS neurons and modulation of synaptic plasticity for more than 20 years. However, integral and noncontradictory hypotheses of their true role in those processes were proposed only recently. This review describes the modern concepts of the involvement of nerve growth factor and brain-derived neurotrophic factor in the maintenance of brain activity and the prospects for their use in therapy.
authors.forename: A D
authors.initials: AD
authors.lastname: Ivanov
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D020932:Nerve Growth Factor / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor; C579455:BDNF protein, human; D020932:Nerve Growth Factor