title: Fragment library design: using cheminformatics and expert chemists to fill gaps in existing fragment libraries.
abstract: Fragment based screening (FBS) has emerged as a mainstream lead discovery strategy in academia, biotechnology start-ups, and large pharma. As a prerequisite of FBS, a structurally diverse library of fragments is desirable in order to identify chemical matter that will interact with the range of diverse target classes that are prosecuted in contemporary screening campaigns. In addition, it is also desirable to offer synthetically amenable starting points to increase the probability of a successful fragment evolution through medicinal chemistry. Herein we describe a method to identify biologically relevant chemical substructures that are missing from an existing fragment library (chemical gaps), and organize these chemical gaps hierarchically so that medicinal chemists can efficiently navigate the prioritized chemical space and subsequently select purchasable fragments for inclusion in an enhanced fragment library.
authors.affiliation: Cheminformatics, Merck Research Laboratories, BMB3-146, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA, peter.kutchukian@merck.com.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Kutchukian
authors.forename: Sung-Sau
authors.initials: SS
authors.lastname: So
authors.forename: Christian
authors.initials: C
authors.lastname: Fischer
authors.forename: Chris L
authors.initials: CL
authors.lastname: Waller
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019295:Computational Biology / Q000379:methods*; D015195:Drug Design; D057166:High-Throughput Screening Assays / Q000379:methods*; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D054852:Small Molecule Libraries