title: Loosening pain's grip by tightening TRPV1-TRPA1 interactions.
abstract: TRPA1 and TRPV1 are ion channels crucial for pain sensation. In this issue of Neuron, Weng et al. (2015) demonstrate that the activity of TRPA1-TRPV1 heteromers is governed by Tmem100 and that disabling Tmem100 may be a novel pharmacologic strategy to combat pain.
authors.affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road Milwaukee, WI 53226, USA.
authors.forename: Andy D
authors.initials: AD
authors.lastname: Weyer
authors.affiliation: Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road Milwaukee, WI 53226, USA. Electronic address: cstucky@mcw.edu.
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Stucky
mesh_terms: D000818:Animals; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000378:metabolism*; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; C556658:Tmem100 protein, mouse; D050051:Transient Receptor Potential Channels; C475685:Trpa1 protein, mouse