title: Predictive role of circulating endothelial-derived microparticles in cardiovascular diseases.
abstract: Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inflammatory diseases. Circulating levels of EMPs are thought to reflect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be defined in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk stratification models.
authors.affiliation: Internal Medicine Department, State Medical University, Zaporozhye, Ukraine.
authors.forename: Alexander
authors.initials: A
authors.lastname: Berezin
authors.affiliation: Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University, St Albans, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Zulli
authors.affiliation: Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland.
authors.forename: Steve
authors.initials: S
authors.lastname: Kerrigan
authors.affiliation: Department of Histology and Embryology, School of Medicine, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovic
authors.affiliation: International Clinical Research Center, St. Anne's University Hospital, Masaryk University, Brno, Czech Republic. Electronic address: peter.kruzliak@savba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D055252:Cell-Derived Microparticles / Q000502:physiology*; D003920:Diabetes Mellitus / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood; D018570:Risk Assessment
chemical_list: D015415:Biomarkers
keywords: Cardiovascular diseases; Endothelial-derived microparticles; Metabolic diseases; Risk stratification