title: Prolapse of all cardiac valves in Noonan syndrome.
abstract: Noonan syndrome is an autosomal dominant disorder with genetically heterogeneous inheritance. The incidence of cardiac abnormalities is higher in patients with Noonan syndrome and approximately 80% patients with Noonan syndrome are reported to have cardiac abnormalities during their lifetimes. However, polyvalvular disease in Noonan syndrome is rare. In this case-report, we describe a case of a young man whose features were strongly suggestive of Noonan syndrome and who was diagnosed with prolapse of all four cardiac valves after 22 years of uneventful survival.
authors.affiliation: Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.
authors.forename: Adikesava Naidu
authors.initials: AN
authors.lastname: Otikunta
authors.affiliation: Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.
authors.forename: Y V
authors.initials: YV
authors.lastname: Subbareddy
authors.affiliation: Department of Cardiology, Osmania General Hospital, Hyderabad, Telangana, India.
authors.forename: Praneeth
authors.initials: P
authors.lastname: Polamuri
authors.affiliation: Clinical Trials, Sahajanand Medical Tech Pvt Ltd, Surat, Gujarat, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Thakkar
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000235:genetics*; D000328:Adult; D003937:Diagnosis, Differential; D005145:Face / Q000002:abnormalities; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000235:genetics*; D016127:Heart Valve Prolapse / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D009634:Noonan Syndrome / Q000175:diagnosis / Q000235:genetics*