title: Significance of trophoblastic infiltration into the tubal wall in ampullary pregnancy.
abstract: A total of 81 patients with an ampullary ectopic pregnancy undergoing salpingectomy were enrolled in the study. The ampullary pregnancies were classified according to the depth of trophoblastic infiltration into tubal wall as follows: Stage I, limited to mucosa; Stage II, extension to the tubal muscularis; Stage III, complete tubal wall infiltration up to the serosa. An association was observed between serum β-human chorionic gonadotropin (β-hCG) levels and the depth of trophoblastic infiltration. Significantly higher severe ischemic changes and rupture of tubal wall were observed in patients with stage III infiltration compared with the other groups. A significant association was found between the absolute depth of trophoblastic invasion and severe ischemic changes, and also rupture of serosa. In conclusion, serum β-hCG levels are associated with depth of trophoblastic invasion into the tubal wall, severe ischemic changes, and rupture of the tubal wall.
authors.affiliation: Antalya Training and Research Hospital, Antalya, Turkey dronurerol@hotmail.com.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Dinc
authors.initials: D
authors.lastname: Suren
authors.affiliation: Akdeniz University, Antalya, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Unal
authors.affiliation: Akdeniz University, Antalya, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Ozel
authors.affiliation: Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kumru
authors.affiliation: Antalya Training and Research Hospital, Antalya, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Sezer
mesh_terms: D000293:Adolescent; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D005187:Fallopian Tubes / Q000473:pathology; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000097:blood / Q000473:pathology*; D012422:Rupture, Spontaneous; D014327:Trophoblasts / Q000473:pathology*; D055815:Young Adult
chemical_list: D006063:Chorionic Gonadotropin
keywords: ampullary pregnancy; histological analysis; trophoblastic infiltration