title: Maturation of human herpesvirus 6A glycoprotein O requires coexpression of glycoprotein H and glycoprotein L.
abstract: Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and required coexpression of gH and gL, which promoted the export of gO out of the endoplasmic reticulum (ER). Finally, we also found that gO was not required for HHV-6A growth in T cells.
authors.affiliation: Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Huamin
authors.initials: H
authors.lastname: Tang
authors.affiliation: Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
authors.forename: Nora F
authors.initials: NF
authors.lastname: Mahmoud
authors.affiliation: Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan ymori@med.kobe-u.ac.jp.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Mori
mesh_terms: D002478:Cells, Cultured; D015870:Gene Expression; D015654:Herpesvirus 6, Human / Q000502:physiology*; D006801:Humans; D011499:Protein Processing, Post-Translational; D013601:T-Lymphocytes / Q000821:virology; D014759:Viral Envelope Proteins / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D014759:Viral Envelope Proteins; C000598485:glycoprotein L, herpesvirus 6; C000598483:glycoprotein O, herpesvirus 6; C070917:glycoprotein H, herpesvirus 6