title: T 1 relaxation measurement of ex-vivo breast cancer tissues at ultralow magnetic fields.
abstract: We investigated T 1 relaxations of ex-vivo cancer tissues at low magnetic fields in order to check the possibility of achieving a T 1 contrast higher than those obtained at high fields. The T 1 relaxations of fifteen pairs (normal and cancerous) of breast tissue samples were measured at three magnetic fields, 37, 62, and 122 μT, using our superconducting quantum interference device-based ultralow field nuclear magnetic resonance setup, optimally developed for ex-vivo tissue studies. A signal reconstruction based on Bayesian statistics for noise reduction was exploited to overcome the low signal-to-noise ratio. The ductal and lobular-type tissues did not exhibit meaningful T 1 contrast values between normal and cancerous tissues at the three different fields. On the other hand, an enhanced T 1 contrast was obtained for the mucinous cancer tissue.
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea.
authors.forename: Seong-Joo
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea.
authors.forename: Jeong Hyun
authors.initials: JH
authors.lastname: Shim
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea ; Department of Medical Physics, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Kiwoong
authors.initials: K
authors.lastname: Kim
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea.
authors.forename: Seong-Min
authors.initials: SM
authors.lastname: Hwang
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea.
authors.forename: Kwon Kyu
authors.initials: KK
authors.lastname: Yu
authors.affiliation: Center for Biosignals, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 305-340, Republic of Korea ; Department of Medical Physics, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon 305-333, Republic of Korea.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lim
authors.affiliation: Department of Pathology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 443-380, Republic of Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Han
authors.affiliation: Department of Pathology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 443-380, Republic of Korea.
authors.forename: Hyunee
authors.initials: H
authors.lastname: Yim
authors.affiliation: Department of Pathology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 443-380, Republic of Korea.
authors.forename: Jang-Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Surgery, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 443-380, Republic of Korea.
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Jung
authors.affiliation: Department of Surgery, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 443-380, Republic of Korea.
authors.forename: Ku Sang
authors.initials: KS
authors.lastname: Kim
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008962:Models, Theoretical; D011859:Radiography
chemical_list: D003287:Contrast Media