title: Kidney injury associated with telavancin dosing regimen in an animal model.
abstract: The elevation of serum creatinine levels is a concern with telavancin therapy. We examined the onset of kidney injury associated with telavancin in an animal model. Urine samples were collected at baseline and daily to determine the concentrations of kidney injury molecule 1 (KIM-1), a marker for early kidney injury. When a clinically relevant exposure of telavancin was given daily to rats, some differences in kidney injury were attributed to the dosing regimen. Further investigations of alternative telavancin dosing regimens are warranted.
authors.affiliation: University of Houston, College of Pharmacy, Houston, Texas, USA vtam@uh.edu.
authors.forename: Vincent H
authors.initials: VH
authors.lastname: Tam
authors.affiliation: University of Houston, College of Pharmacy, Houston, Texas, USA.
authors.forename: Kimberly R
authors.initials: KR
authors.lastname: Ledesma
authors.affiliation: University of Houston, College of Pharmacy, Houston, Texas, USA.
authors.forename: Dana R
authors.initials: DR
authors.lastname: Bowers
authors.affiliation: University of Houston, College of Pharmacy, Houston, Texas, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Houston Methodist Hospital, Houston, Texas, USA Weill Cornell Medical College, New York, New York, USA.
authors.forename: Luan D
authors.initials: LD
authors.lastname: Truong
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects*; D000818:Animals; D015415:Biomarkers; D015815:Cell Adhesion Molecules / Q000652:urine; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000382:microbiology; D000077427:Lipoglycopeptides; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000617:Aminoglycosides; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D000077427:Lipoglycopeptides; C110936:Havcr1 protein, rat; C487637:telavancin