title: Recurrent focal segmental glomerulosclerosis after kidney transplantation.
abstract: Focal segmental glomerulosclerosis (FSGS) is an important cause of glomerular disease in children and adolescents and nearly 50 % of affected patients will progress to end-stage kidney disease over a 5 to 10-year period. Unfortunately, there is no established treatment for disease in the native kidney. Moreover, up to 55 % of patients develop recurrent disease after receiving a kidney transplant, with a substantially higher risk in patients who have already experienced recurrent disease in a prior transplant. A number of clinical and laboratory factors have been identified as risk factors for this complication. In addition, new investigations into podocyte biology and circulating permeability factors have shed light on the cause of recurrent the disease. While a number of novel therapeutic agents have been applied in the management of this problem, there still is no proven treatment. In this review, we summarize recent advances in the epidemiology, pathophysiology, and treatment of recurrent FSGS in pediatric patients who have received a kidney transplant.
authors.affiliation: Division of Pediatric Nephrology, NYU Langone Medical Center, CTSI, Room #733 227 E 30th Street, New York, NY, 10016, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Trachtman
authors.forename: Simranjeet S
authors.initials: SS
authors.lastname: Sran
authors.forename: Howard
authors.initials: H
authors.lastname: Trachtman
mesh_terms: D005923:Glomerulosclerosis, Focal Segmental / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D010956:Plasmapheresis / Q000379:methods*; D012008:Recurrence; D012307:Risk Factors