title: Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features.
abstract: Human papillomavirus (HPV) related squamous cell carcinoma (SCC) involving the anal canal is a well-known carcinoma associated with high-risk types of HPV. HPV-related SCC with papillary morphology (papillary SCC) has been described in the oropharynx. We describe, for the first time, a case of anal HPV-related squamous carcinoma with papillary morphology. The tumor arose from the anal mucosa. The biopsies revealed a superficially invasive SCC with prominent papillary features and associated in situ carcinoma. The tumor cells were positive for p16 and were also positive for high-risk types of HPV using chromogenic in situ hybridization. The findings are consistent with a HPV-related SCC of the anal canal with papillary features. This tumor shows histologic features similar to a papillary HPV-related SCC of the oropharynx. Additional studies are needed to characterize these lesions.
authors.affiliation: Marino E Leon, Domenico Coppola, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States.
authors.forename: Marino E
authors.initials: ME
authors.lastname: Leon
authors.affiliation: Marino E Leon, Domenico Coppola, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States.
authors.forename: Rania
authors.initials: R
authors.lastname: Shamekh
authors.affiliation: Marino E Leon, Domenico Coppola, Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States.
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
mesh_terms: D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy / Q000821:virology; D059248:Chemoradiotherapy; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D061809:Human Papillomavirus DNA Tests; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004279:DNA, Viral
keywords: Anus; Carcinoma in situ; Human papillomavirus; Papillary; Squamous cell carcinoma