title: Behavior of stem cells under outer-space microgravity and ground-based microgravity simulation.
abstract: With rapid development of space engineering, research on life sciences in space is being conducted extensively, especially cellular and molecular studies on space medicine. Stem cells, undifferentiated cells that can differentiate into specialized cells, are considered a key resource for regenerative medicine. Research on stem cells under conditions of microgravity during a space flight or a ground-based simulation has generated several excellent findings. To help readers understand the effects of outer space and ground-based simulation conditions on stem cells, we reviewed recent studies on the effects of microgravity (as an obvious environmental factor in space) on morphology, proliferation, migration, and differentiation of stem cells.
authors.affiliation: Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
authors.forename: Cui
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
authors.forename: Jianling
authors.initials: J
authors.lastname: Chen
authors.affiliation: Institute of Cell and Development Biology, College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058, P. R. China.
authors.forename: Jinfu
authors.initials: J
authors.lastname: Wang
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D010012:Osteogenesis; D013026:Space Flight; D013234:Stem Cells / Q000166:cytology*; D014893:Weightlessness; D018474:Weightlessness Simulation
keywords: development; differentiation; microgravity; stem cells; tissue engineering