title: [In vitro study of the flow duration of antibiotics solutions prepared in elastomeric infusion devices: effect of cold storage for 3 to 7days].
abstract: BACKGROUND
  Within the cystic fibrosis patients' home care, EMERAA network ("Together against Cystic fibrosis in Rhone-Alpes and Auvergne") organizes parenteral antibiotics cures at home prepared in elastomeric infusion devices by hospital pharmacies. However, patients and nurses found that the durations of infusion with these devices were often longer than the nominal duration of infusion indicated by their manufacturer. This study aimed to identify the potential different causes in relation to these discordances.
  
  
  METHODS
  Three hundred and ninety devices of two different manufacturers are tested in different experimental conditions: three antibiotics each at two different doses, duration of cold storage (three days or seven days) or immediate tests without cold storage, preparation and storage of the solution in the device (protocol Device) or transfer in the device just before measurement (protocol Pocket).
  
  
  RESULTS
  All tests highlighted a longer flow duration for devices prepared according to the protocol Device versus the protocol Pocket (P=0.004). Flow duration is increased in the case of high doses of antibiotics with high viscosity such as piperacilline/tazobactam.
  
  
  CONCLUSIONS
  The results of this in vitro study showed the impact of: (1) the time between the filling of the device and the flow of the solution; (2) cold storage of elastomeric infusion devices; (3) concentration of antibiotics and therefore the viscosity of the solution to infuse.
  
  
  CONCLUSIONS
  It is therefore essential that health care teams are aware of factors, which may lead to longer infusion durations with these infusion devices. When the additional time for infusion remain acceptable, it should be necessary to inform the patient and to relativize these lengthening compared to many benefits that these devices provide for home care.
authors.affiliation: Pôle pharmacie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France. Electronic address: grangeon.c@chu-nice.fr.
authors.forename: C
authors.initials: C
authors.lastname: Grangeon-Chapon
authors.affiliation: Pôle pharmacie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Robein-Dobremez
authors.affiliation: Pôle couple-enfant, centre de ressources et de compétences de la mucoviscidose, pédiatrie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.affiliation: Pôle pharmacie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: P
authors.initials: P
authors.lastname: Trouiller
authors.affiliation: Pôle pharmacie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France; Laboratoire ThEMAS TIMC-IMAG UMR CNRS 5525, université Joseph-Fourier, domaine de La Merci, 38706 La Tronche cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Allenet
authors.affiliation: Pôle pharmacie, CHU de Grenoble, boulevard de la Chantourne, CS 10217, 38043 Grenoble cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Foroni
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use; D003080:Cold Temperature; D003550:Cystic Fibrosis / Q000188:drug therapy; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D020724:Elastomers / Q000008:administration & dosage*; D017022:Flow Injection Analysis; D007260:Infusion Pumps; D019999:Pharmaceutical Solutions
chemical_list: D000900:Anti-Bacterial Agents; D020724:Elastomers; D019999:Pharmaceutical Solutions
keywords: Antibiotic; Antibiotique; Cold storage; Cystic fibrosis; Diffuseur portable élastomérique; Duration of infusion; Durée de perfusion; Elastomeric infusion device; Home care; Mucoviscidose; Réfrigération; Traitement à domicile