title: [Clinical associations of genetic variants of interleukins with the formation of chronic lympholeukemia in elderly patients].
abstract: We investigated association of polymorphisms of interleukin IA (IL-1A), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin-8 (1L-8) genes in elderly patients with predisposition to the development of chronic lym,nphocytic leukemia (CLL). Risk factor of chronic lymphocytic leukemia is a genetic variant -590T IL-4 (OR = 1,45) and protective factor -590S IL-4 (OR = 0,68). Genetic markers -590T IL-4 (OR = 2,46), -590TT IL-4 (OR = 6,65) and mix-590TT genotype of IL-4 allele 703S-IL-5 (OR = 6.70) were associated with stage 0-1 chronic lymphocytic leukemia whereas genetic markers -889T IL-1A (OR = 1,51), -703T IL-5 (OR = 1,52) and a combination of genotype -703ST IL-5 allele-251A IL-8 (OR = 2.85) were related to the development of stage II of the disease. Risk factor for the formation of II-IV stages of chronic lymphocytic leukemia is a genetic variant -703T IL-5 (OR = 1,95).
authors.forename: S S
authors.initials: SS
authors.lastname: Sirotina
authors.forename: T S
authors.initials: TS
authors.lastname: Tikunova
authors.forename: K I
authors.initials: KI
authors.lastname: Proshchaev
authors.forename: O A
authors.initials: OA
authors.lastname: Efremova
authors.forename: M I
authors.initials: MI
authors.lastname: Churnosov
authors.forename: A A
authors.initials: AA
authors.lastname: Sirotin
authors.forename: V I
authors.initials: VI
authors.lastname: Evdokimov
authors.forename: A N
authors.initials: AN
authors.lastname: Poltoratskii
authors.forename: M V
authors.initials: MV
authors.lastname: Smagina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D007378:Interleukins