title: Targeted Immunotherapy Designed to Treat MUC1-Expressing Solid Tumour.
abstract: Several approaches to antigen-specific immunotherapy of cancer antigen-specific immunotherapy of cancer have been tested clinically. In this chapter, we will describe studies done with the antigen MUC1. Tested MUC1 therapeutic vaccines include the following: monoclonal antibodies (MAbs) specific for MUC1; synthetic and recombinant polypeptides from the protein sequence of MUC1; dendritic cells carrying MUC1; RNA and DNA vaccinations; and recombinant viruses carrying the MUC1 DNA sequence. Chemotherapy of cancer aims to be toxic to the cancer cells with manageable side effects to the patient. In contrast, antigen-specific immunotherapy of cancer aims to treat the patient, such that the patient is then able to control and eventually eliminate their cancer cells. It is therefore important to know the immune status of each cancer patient prior to therapy.
authors.affiliation: Bruce Acres Consulting, Strasbourg, France.
authors.forename: Bruce
authors.initials: B
authors.lastname: Acres
authors.affiliation: Department of Medical Affairs, Transgene SA, 400 Blvd Gonthier d'Andernach, Parc d'Innovation CS80166, 67405, Illkirch-Graffenstaden Cedex, France. lacoste@transgene.fr.
authors.forename: Gisele
authors.initials: G
authors.lastname: Lacoste
authors.affiliation: Department of Medical Affairs, Transgene SA, 400 Blvd Gonthier d'Andernach, Parc d'Innovation CS80166, 67405, Illkirch-Graffenstaden Cedex, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Limacher
mesh_terms: D019496:Cancer Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D018396:Mucin-1 / Q000276:immunology*; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D019496:Cancer Vaccines; C060192:MUC1 protein, human; D018396:Mucin-1