title: [Impact of autosomal dominant polycystic kidney disease on the outcomes of intracytoplasmic sperm injection in infertile males].
abstract: OBJECTIVE
  To summarize the features and treatment of male infertility induced by autosomal dominant polycystic kidney disease (ADPKD), and compare the outcomes of intracytoplasmic sperm injection (ICSI) for infertile men with ADPKD and those with congenital bilateral absence of vas deferens (CBAVD).
  
  
  METHODS
  We retrospectively analyzed 21 cases of ADPKD-induced infertility, 15 treated by ICSI (group A), and another 164 cases of strictly matched CBAVD-induced infertility (group B). We compared the two groups in the couples' age, the number of ICSI oocytes, and the rates of fertilization, transferrable embryos, good embryos, embryos implanted, clinical pregnancy, biochemical pregnancy, early abortion, singleton and twins in the first cycle.
  
  
  RESULTS
  After 28 cycles of ICSI, 10 of the 15 ADPKD-induced infertility patients achieved clinical pregnancy, including 7 cases of live birth, 1 case of spontaneous abortion, and 2 cases of pregnancy maintenance. No significant differences were observed between groups A and B in the couples' age, the wives' BMI, or the numbers of ICSI oocytes and embryos transplanted (P >0.05), nor in the rates of ICSI fertilization (72.64% vs 76.17%), transferrable embryos (51.28% vs 63.24%), quality embryos (38.46% vs 49.83%), embryo implantation (17.64% vs 38.50%), abortion (0 vs 9.23%), singleton (50% vs 81.54%) and twins (50% vs 18.46%). However, the rates of clinical pregnancy (13.33% vs 42.68%, P = 0.023 <0.05) and biochemical pregnancy (13.33% vs 39.63%, P = 0.032 <0.05) were significantly lower in group A than in B.
  
  
  CONCLUSIONS
  ICSI is effective in the treatment of male infertility induced by either ADPKD or CBAVD, but the ADPKD cases have a lower success rate than the CBAVD cases in an individual cycle. The affected couples should be informed of the necessity of prenatal genetic diagnosis before embryo implantation and the inevitable vertical transmission of genetic problems to the offspring.
authors.forename: Huang
authors.initials: H
authors.lastname: Su
authors.forename: Bian-jiang
authors.initials: BJ
authors.lastname: Liu
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Ning-hong
authors.initials: NH
authors.lastname: Song
authors.forename: Chang-jun
authors.initials: CJ
authors.lastname: Yin
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Jia-yin
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000022:Abortion, Spontaneous; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D052801:Male Urogenital Diseases / Q000628:therapy*; D009865:Oocytes; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014649:Vas Deferens / Q000002:abnormalities*