title: Some design considerations for polymer-free drug-eluting stents: a mathematical approach.
abstract: In this paper we provide the first model of drug elution from polymer-free arterial drug-eluting stents. The generalised model is capable of predicting drug release from a number of polymer-free systems including those that exhibit nanoporous, nanotubular and smooth surfaces. We derive analytical solutions which allow us to easily determine the important parameters that control drug release. Drug release profiles are provided, and we offer design recommendations so that the release profile may be tailored to achieve the desired outcome. The models presented here are not specific to drug-eluting stents and may also be applied to other biomedical implants that use nanoporous surfaces to release a drug.
authors.affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XH, UK. Electronic address: s.mcginty@strath.ac.uk.
authors.forename: Sean
authors.initials: S
authors.lastname: McGinty
authors.affiliation: MACSI, Department of Mathematics and Statistics, University of Limerick, Limerick, Ireland.
authors.forename: Tuoi T N
authors.initials: TTN
authors.lastname: Vo
authors.affiliation: Department of Applied Mathematics, NUI Galway, Galway, Ireland.
authors.forename: Martin
authors.initials: M
authors.lastname: Meere
authors.affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XH, UK.
authors.forename: Sean
authors.initials: S
authors.lastname: McKee
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow G4 0NW, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: McCormick
mesh_terms: D016503:Drug Delivery Systems; D065546:Drug Liberation; D054855:Drug-Eluting Stents; D008962:Models, Theoretical; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012995:Solubility
chemical_list: D011108:Polymers
keywords: Diffusion; Dissolution; Drug release; Nanoporous materials; Polymer-free stents