title: Neck circumference has possibility as a predictor for metabolic syndrome in postmenopausal women.
abstract: Subcutaneous fat depots play an important role in regulating metabolic profile in Japanese postmenopausal women. We investigated the possibility of neck circumference (NC) as a surrogate marker for metabolic disease risk estimates in Japanese postmenopausal women. We examined the association of NC with several markers of insulin resistance, lipid metabolism and atherosclerosis in 64 healthy postmenopausal women aged 63.6 ± 7.1 years in community-based samples in Japan. As a result, NC was significantly associated with indices of whole body obesity and visceral fat accumulation, such as body mass index (BMI) and Waist circumference (WC). In the analysis of biomarkers for insulin resistance, NC was positively correlated to HbA1c, homeostasis model assessment ratio (HOMA-R) and leptin. In addition, an increase in triglycerides (TG) and a decrease in HDL-cholesterol (HDL-C) were also associated with NC. Interestingly, NC was also associated with atherosclerosis-related indices. The measurement of NC is an easy, inexpensive and reproducible method for assessment of obesity, and a possible predictor to identify the risk for future metabolic diseases in Japanese postmenopausal women.
authors.forename: Satomi
authors.initials: S
authors.lastname: Aoi
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyake
authors.forename: Toshihide
authors.initials: T
authors.lastname: Harada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ishizaki
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nitta
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Iida
authors.forename: Chiho
authors.initials: C
authors.lastname: Chikamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Tamura
authors.forename: Kohsaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Hideki
authors.initials: H
authors.lastname: Miyaguchi
mesh_terms: D000368:Aged; D000886:Anthropometry / Q000379:methods*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000175:diagnosis*; D008875:Middle Aged; D009333:Neck / Q000033:anatomy & histology*; D009765:Obesity / Q000175:diagnosis*; D017698:Postmenopause; D011237:Predictive Value of Tests; D055105:Waist Circumference