title: Deferiprone, a non-toxic reagent for determination of iron in samples via sequential injection analysis.
abstract: We present for the first time the use of deferiprone as a non-toxic complexing agent for the determination of iron by sequential injection analysis in pharmaceuticals and food samples. The method was based on the reaction of Fe(III) and deferiprone in phosphate buffer at pH 7.5 to give a Fe(III)-deferiprone complex, which showed a maximum absorption at 460nm. Under the optimum conditions, the linearity range for iron determination was found over the range of 0.05-3.0μgmL(-1) with a correlation coefficient (r(2)) of 0.9993. The limit of detection and limit of quantitation were 0.032μgmL(-1) and 0.055μgmL(-1), respectively. The relative standard deviation (%RSD) of the method was less than 5.0% (n=11), and the percentage recovery was found in the range of 96.0-104.0%. The proposed method was satisfactorily applied for the determination of Fe(III) in pharmaceuticals, water and food samples with a sampling rate of 60h(-1).
authors.affiliation: Center of Excellence for Innovation in Chemistry and Department of Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Kantarawichai District, Mahasarakham 44150, Thailand.
authors.forename: Kraivinee
authors.initials: K
authors.lastname: Pragourpun
authors.affiliation: Center of Excellence for Innovation in Chemistry and Department of Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Kantarawichai District, Mahasarakham 44150, Thailand.
authors.forename: Uthai
authors.initials: U
authors.lastname: Sakee
authors.affiliation: School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen AB10 7GJ, United Kingdom.
authors.forename: Carlos
authors.initials: C
authors.lastname: Fernandez
authors.affiliation: Center of Excellence for Innovation in Chemistry and Department of Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Kantarawichai District, Mahasarakham 44150, Thailand. Electronic address: Seiney@yahoo.com.
authors.forename: Senee
authors.initials: S
authors.lastname: Kruanetr
mesh_terms: D000077543:Deferiprone; D004867:Equipment Design; D017022:Flow Injection Analysis / Q000295:instrumentation*; D005504:Food Analysis / Q000295:instrumentation; D007202:Indicators and Reagents; D007501:Iron / Q000032:analysis*; D057230:Limit of Detection; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*; D013053:Spectrophotometry / Q000295:instrumentation*; D014867:Water / Q000032:analysis
chemical_list: D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011728:Pyridones; D014867:Water; D000077543:Deferiprone; D007501:Iron
keywords: Deferiprone; Iron; Sequential injection