title: Elevated baseline plasma phospholipid protein (PLTP) levels are an independent predictor of long-term all-cause mortality in patients with diabetes mellitus and known or suspected coronary artery disease.
abstract: OBJECTIVE
  To investigate the long-term prognostic significance of baseline plasma PLTP levels in a group of well-characterized male patients with diabetes mellitus and known or suspected coronary artery disease referred for coronary angiography.
  
  
  BACKGROUND
  PLTP is a plasma protein that mediates the net transfer and exchange of phospholipids between lipoproteins. It has been implicated in the pathogenesis of atherosclerosis and elevated plasma levels have been reported in patients with diabetes mellitus.
  
  
  METHODS
  Baseline plasma PLTP levels were measured in 154 male patients with diabetes mellitus who were referred for coronary angiography and followed prospectively for 5 years for the development of all-cause mortality.
  
  
  RESULTS
  After adjustment for a variety of baseline clinical, angiographic and laboratory parameters, plasma PLTP levels (analyzed as a continuous variable) were an independent predictor of all-cause mortality at 5 years (HR, 1.55; 95% CI, 1.22-2.00; P = 0.0009). Furthermore, in 3 additional multivariate models that also included a wide variety of contemporary biomarkers with established prognostic efficacy (i.e., ST2, GDF-15, Cystatin C, Fibrinogen, and NT-proBNP), PLTP remained an independent predictor of all-cause mortality at 5 years.
  
  
  CONCLUSIONS
  Elevated baseline plasma levels of PLTP are associated with an increased risk of long-term all-cause mortality in patients with diabetes and known or suspected coronary disease. Furthermore, this association is independent of a variety of clinical, angiographic, and laboratory variables, including a whole host of contemporary biomarkers with established prognostic efficacy.
authors.affiliation: Division of Cardiology, Department of Medicine, Bronx Veterans Affairs Medical Center, Bronx, NY, USA; Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA. Electronic address: ECavusoglu@aol.com.
authors.forename: Erdal
authors.initials: E
authors.lastname: Cavusoglu
authors.affiliation: Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Marmur
authors.affiliation: Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Chhabra
authors.affiliation: Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Hojjati
authors.affiliation: Division of Cardiology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Sunitha
authors.initials: S
authors.lastname: Yanamadala
authors.affiliation: Division of Cardiology, Department of Medicine, Bronx Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Vineet
authors.initials: V
authors.lastname: Chopra
authors.affiliation: Division of Cardiology, Department of Medicine, Bronx Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Calvin
authors.initials: C
authors.lastname: Eng
authors.affiliation: Department of Anatomy and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
authors.forename: Xian-Cheng
authors.initials: XC
authors.lastname: Jiang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D049294:Phospholipid Transfer Proteins / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins
keywords: Acute coronary syndrome; Atherosclerosis; Biomarkers; Diabetes mellitus; Mortality; Myocardial infarction; PLTP; Phospholipid transfer protein; Prognosis