title: Preferential carriage of class 2 integrons in Acinetobacter baumannii CC113 and novel singletons.
abstract: Our understanding of the distribution of integrons associated with multidrug resistance in Acinetobacter baumannii isolates around the world remains incomplete. The association between the class 1 and 2 integron A. baumannii-positive isolates (n = 60), recovered since 1982 from 11 Argentinean hospitals, and the circulating lineages, was investigated. While class 2 integrons were highly significantly associated with clonal lineage CC113B/CC79P (P = 0·009) and novel singletons (P = 0·001), class 1 integrons were found not to be associated with CC109B/CC1P or other lineages. The study reveals a differential distribution of class 2 integrons in lineages, and suggests that the prevalence of intI2 in Argentina is related to the emergence of novel singletons in recent years and to the abundance of CC113B/CC79P, which has been the local dominant lineage for several decades.
authors.affiliation: Instituto de Microbiología y Parasitología Médica (IMPaM, UBA-CONICET),Facultad de Medicina,Universidad de Buenos Aires,Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Ramírez
authors.affiliation: Instituto de Microbiología y Parasitología Médica (IMPaM, UBA-CONICET),Facultad de Medicina,Universidad de Buenos Aires,Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Montaña
authors.affiliation: Grupo GEMA,Departamento de Ciencias Básicas,Universidad Nacional de Luján,Luján,Buenos Aires,Argentina & Laboratorio de Biología del Comportamiento,IBYME,Ciudad Autónoma de Buenos Aires,Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Cassini
authors.affiliation: Instituto de Microbiología y Parasitología Médica (IMPaM, UBA-CONICET),Facultad de Medicina,Universidad de Buenos Aires,Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Centrón
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D040981:Acinetobacter baumannii / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D001118:Argentina / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D005838:Genotype; D006801:Humans; D032023:Integrons; D017720:Molecular Epidemiology
keywords: Acinetobacter; integron; lineages