title: Emergence of KPC-2-producing Pseudomonas aeruginosa sequence type 463 isolates in Hangzhou, China.
abstract: Thirty-nine Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa isolates, all exhibiting high-level resistance to carbapenems and other β-lactam antibiotics, were isolated in Hangzhou, China. Molecular epidemiology analysis indicated the presence of two dominant clones, namely, clones A and B, both of which belong to sequence type 463 (ST463). A genetic environment analysis demonstrated that both clones harbor an ISKpn8 transposase, bla(KPC-2), and an ISKpn6-like transposase. These findings depict the features of clonal expansion and transmission of KPC-2-producing P. aeruginosa strains in Hangzhou, China.
authors.affiliation: 2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Hu
authors.affiliation: 2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Dan-xia
authors.initials: DX
authors.lastname: Gu
authors.affiliation: 2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Jia-chang
authors.initials: JC
authors.lastname: Cai
authors.affiliation: 2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Zhou
authors.affiliation: 2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China brigitte_zr@163.com.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology*; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047090:beta-Lactams; D001618:beta-Lactamases; C063912:carbapenemase