title: Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni.
abstract: In Part II we discuss the following bacterial pathogens: Shigella, Salmonella (non-typhoidal), diarrheogenic E. coli (enterotoxigenic and enterohemorragic) and Campylobacter jejuni. In contrast to the enteric viruses and Vibrio cholerae discussed in Part I of this series, for the bacterial pathogens described here there is only one licensed vaccine, developed primarily for Vibrio cholerae and which provides moderate protection against enterotoxigenic E. coli (ETEC) (Dukoral(®)), as well as a few additional candidates in advanced stages of development for ETEC and one candidate for Shigella spp. Numerous vaccine candidates in earlier stages of development are discussed.
authors.affiliation: a Microbiology and Mycology Program; Institute of Biomedical Sciences; Faculty of Medicine; Universidad de Chile; Santiago, Chile.
authors.forename: Miguel
authors.initials: M
authors.lastname: O'Ryan
authors.forename: Roberto
authors.initials: R
authors.lastname: Vidal
authors.forename: Felipe
authors.initials: F
authors.lastname: del Canto
authors.forename: Juan
authors.initials: J
authors.lastname: Carlos Salazar
authors.forename: David
authors.initials: D
authors.lastname: Montero
mesh_terms: D001428:Bacterial Vaccines / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D017277:Drug Approval; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology*; D005759:Gastroenteritis / Q000453:epidemiology / Q000382:microbiology / Q000469:parasitology / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D012475:Salmonella / Q000276:immunology*; D012760:Shigella / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines
keywords: CFU, colony-forming units; CFs, colonization factors; CT, cholera toxin; CT-B cholera toxin B subunit; Campylobacter; CtdB, cytolethal distending toxin subunit B; E. coli; EHEC; EPEC, enteropathogenic E. coli; ETEC; ETEC, enterotoxigenic E. coli; GEMS, Global enterics multicenter study; HUS, hemolytic uremic syndrome; IM, intramuscular; IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; LEE, locus of enterocyte effacement; LPS, lipopolysaccharide; LT, heat labile toxin; LT-B; OMV, outer membrane vesicles; ST, heat stable toxin; STEC; STEC, shigatoxin producing E. coli; STh, human heat stable toxin; STp, porcine heat stable toxin; Salmonella; Shigella; Stx, shigatoxin; TTSS, type III secretion system; V. cholera; WHO, World Health Organization; acute diarrhea; dmLT, double mutant heat labile toxin; enteric pathogens; enterohemorrhagic E. coli; gastroenteritis; heat labile toxin B subunit; norovirus; rEPA, recombinant exoprotein A of Pseudomonas aeruginosa; rotavirus; vaccines