title: The psychiatric and neuropsychiatric symptoms after subthalamic stimulation for Parkinson's disease.
abstract: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for the motor symptoms of Parkinson's disease (PD). Nonmotor features of PD, however, may not improve with STN DBS, and a specific constellation of neuropsychiatric symptoms may emerge in the postoperative period. Mania, impulsivity, depression, and apathy may curtail the potential gains from surgery. In this paper, the authors discuss surgical candidacy, postoperative management of neuropsychiatric issues, and clinical dilemmas for the psychiatrist at the DBS center. A paradigm that considers stimulation effects and dopamine replacement therapy to be key drivers of postoperative neuropsychiatric problems is presented.
authors.affiliation: From the The University of Queensland, UQ Centre for Clinical Research, Herston, Queensland, Australia; Dept. of Psychiatry, Royal Brisbane & Women's Hospital, Herston, Queensland, Australia; and Neurosciences Queensland, St Andrew's War Memorial Hospital, Spring Hill, Queensland, Australia.
authors.forename: Philip E
authors.initials: PE
authors.lastname: Mosley
authors.forename: Rodney
authors.initials: R
authors.lastname: Marsh
mesh_terms: D001526:Behavioral Symptoms / Q000209:etiology*; D003072:Cognition Disorders / Q000209:etiology*; D046690:Deep Brain Stimulation / Q000009:adverse effects*; D006801:Humans; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000628:therapy; D020531:Subthalamic Nucleus / Q000502:physiology*