title: Interest of antioxidant agents in parasitic diseases. The case study of coumarins.
abstract: Tropical parasitic diseases, especially those produced by protozoan parasites, are a major public health problem in many countries, and their impact in the health burden is significant. Oxidative processes proved to be related to these diseases, being the antioxidant agents promising therapeutic solutions for them. Therefore, this review provides an overview of published manuscripts regarding both activities. In particular, the interest of the coumarin derivatives as antioxidant agents with application in parasitic diseases is discussed in this manuscript. The recent findings in this field are highlighted.
authors.forename: Roberto
authors.initials: R
authors.lastname: Figueroa-Guiñez
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Matos
authors.forename: Saleta
authors.initials: S
authors.lastname: Vazquez-Rodriguez
authors.forename: Lourdes
authors.initials: L
authors.lastname: Santana
authors.forename: Eugenio
authors.initials: E
authors.lastname: Uriarte
authors.forename: Fernanda
authors.initials: F
authors.lastname: Borges
authors.affiliation: Departamento de Quimica Inorganica y Analitica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago. colea@uchile.cl.
authors.forename: Claudio
authors.initials: C
authors.lastname: Olea-Azar
authors.affiliation: Departamento de Farmacologia Molecular y Clinica, Facultad de Medicina, Universidad de Chile, Santiago, Chile. jdmaya@u.uchile.cl.
authors.forename: Juan Diego
authors.initials: JD
authors.lastname: Maya
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D014355:Chagas Disease / Q000188:drug therapy / Q000378:metabolism; D003374:Coumarins / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D055808:Drug Discovery; D006801:Humans; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D010272:Parasitic Diseases / Q000188:drug therapy* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D003374:Coumarins; D017382:Reactive Oxygen Species