title: Vitamin D status in men with psoriatic arthritis: a case-control study.
abstract: We determined hypovitaminosis D prevalence in men with psoriatic arthritis. This is a cross-sectional, analyst blinded, age- and sex-matched, case-control study. Men with psoriatic arthritis have significantly lower 25-hydroxyvitamin D levels. Men with psoriatic arthritis are at increased odds of suffering from hypovitaminosis D.
  
  
  BACKGROUND
  Skeletal manifestations as a result of abrupted bone metabolism may be predominant in psoriatic arthritis (PsA). Vitamin D plays a vital role in maintenance of skeletal health and is known to modulate the immune system in various autoimmune diseases including PsA. The aim of the present study was to determine the prevalence of hypovitaminosis D in a treatment naïve, de novo psoriatic arthritis male cohort in a cross-sectional, analyst blinded, age- and sex-matched, case-control study.
  
  
  METHODS
  25 hydroxyvitamin D (25OHD), parathyroid (PTH), osteocalcin (OC) and C-terminal telopeptides of type-I collagen (CTx) levels, and lumbar spine and femoral neck bone mineral density were compared between 53 PsA and controls.
  
  
  RESULTS
  The prevalence of hypovitaminosis D (25 hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and 57 % in the PsA and control groups, respectively. Compared to the healthy controls, 25OHD (67.2 (12-137) nmol/L vs. 51.9 (15-95) nmol/L; p = 0.001) was significantly lower, and osteocalcin (13.6 (5-33) μg/L vs. 18.2 (6-35) μg/L; p = 0.003) and C-terminal telopeptides of type-I collagen (0.20 (0.01-0.71) μg/L vs. 0.28 (0.06-0.69) μg/L; p = 0.008) were significantly higher in the PsA group. A significant association was found between hypovitaminosis D and PsA; the odds for patients with PsA of having hypovitaminosis D was 3.297 (95 % confidence interval 1.372 to 7.922).
  
  
  CONCLUSIONS
  The results of this study suggest that men with PsA have significantly lower 25-hydroxyvitamin D levels, and furthermore, men with PsA are at statistically significant increased odds of suffering from hypovitaminosis D.
authors.affiliation: Department of Rheumatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Petho
authors.forename: E
authors.initials: E
authors.lastname: Kulcsar-Jakab
authors.forename: E
authors.initials: E
authors.lastname: Kalina
authors.forename: A
authors.initials: A
authors.lastname: Balogh
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
authors.forename: K
authors.initials: K
authors.lastname: Gulyas
authors.forename: A
authors.initials: A
authors.lastname: Horvath
authors.forename: Z
authors.initials: Z
authors.lastname: Szekanecz
authors.forename: H P
authors.initials: HP
authors.lastname: Bhattoa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015535:Arthritis, Psoriatic / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D015519:Bone Density / Q000502:physiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D