title: [Serum anti endomysial and anti transglutaminase antibodies in patients with connective tissue diseases].
abstract: BACKGROUND
  The detection of anti-transglutaminase IgA (tTG) and anti-endomysial (EMA) is used for screening of celiac disease (CD) with a sensitivity and specificity of 90 and 99% respectively. There is an association between CD and connective tissue diseases (CTD).
  
  
  OBJECTIVE
  To report the frequency of IgA tTG and EMA in patients with a definite diagnosis of CTD and inflammatory arthropathies (IA).
  
  
  METHODS
  One hundred forty nine patients, aged 19 to 86 years (133 females) with CTD and IA were studied. tTG were determined by ELISA and EMA by indirect immunofluorescence.
  
  
  RESULTS
  Eight participants had at least one positive antibody (5.4%, confidence intervals (CI) = 1.8-9), six had both (4.0% CI = 0.9-7.2) and two had only tTG positive. An intestinal biopsy was performed in four of these participants, finding a marked villous atrophy in three and partial atrophy in one.
  
  
  CONCLUSIONS
  Five percent of this group of patients with CTD or IA had positive antibodies for CD.
authors.forename: Graciela Rita
authors.initials: GR
authors.lastname: Rodríguez
authors.forename: Federico
authors.initials: F
authors.lastname: Zazzetti
authors.forename: Silvia Raquel
authors.initials: SR
authors.lastname: da Representaçao
authors.forename: María Verónica
authors.initials: MV
authors.lastname: Lencina
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barreira
authors.forename: Karina Elizabeth
authors.initials: KE
authors.lastname: Álvarez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D001168:Arthritis / Q000150:complications*; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis*; D003240:Connective Tissue Diseases / Q000276:immunology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; C049937:anti-IgA; D011503:Transglutaminases