title: The three-body problem of therapy with induced pluripotent stem cells.
abstract: Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.
authors.affiliation: Stem Cell Institute and Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, 420 Delaware St SE, MMC 366, Minneapolis, MN 55455 USA.
authors.forename: Jakub
authors.initials: J
authors.lastname: Tolar
authors.affiliation: St John's Institute of Dermatology, King's College London, Floor 9 Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT UK.
authors.forename: John A
authors.initials: JA
authors.lastname: McGrath