title: Five new diarylheptanoids from the rhizomes of Curcuma kwangsiensis and their antiproliferative activity.
abstract: Five new diarylheptanoids (1-5), along with nine known ones (6-14), were isolated from the rhizomes of Curcuma kwangsiensis. Their structures were established on the basis of spectroscopic analyses. Compounds 1-3 were cyclic diarylheptanoids rarely discovered from C. kwangsiensis. Of all the isolated compounds, compound 4 showed moderate antiproliferative activity on HH and HaCaT cells.
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China; Postdoctoral Programme, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Chen
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Gao
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
authors.forename: Jing-Gong
authors.initials: JG
authors.lastname: Liu
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China.
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Zhao
authors.affiliation: The Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China. Electronic address: luchuanjian888@vip.sina.com.
authors.forename: Chuan-Jian
authors.initials: CJ
authors.lastname: Lu
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D030024:Curcuma / Q000737:chemistry*; D036381:Diarylheptanoids / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D027343:Rhizome / Q000737:chemistry*
chemical_list: D036381:Diarylheptanoids
keywords: Antiproliferation; Curcuma kwangsiensis; Diarylheptanoids; HH cells; HaCaT cells