title: Calcium and phosphorus metabolism and lithogenic factors in patients with osteoporotic fracture.
abstract: OBJECTIVE
  To demonstrate the attendance of mineral metabolism disorders and lithogenic factors in patients' urine with osteoporotic fracture without previously known stones
  
  
  METHODS
  67 patients with osteoporotic fractures surgically treated in trauma service are included. The area of the fracture site, fracture mechanism and the presence of osteoporosis were the factors taken into account to diagnose osteoporotic fracture. Mineral metabolism, calciuria, oxaluria, uricosuria and citraturia in 24hours urine were analyzed. The presence of abnormal calcium and phosphorus metabolism was proved comparing hypercalciuria patients with normocalciuria ones.
  
  
  RESULTS
  12 men and 55 women with mean age 68.8±14.5 years old were included. Mean Body Mass Index (BMI) was 27.4±4.1kg/m2. 42% of patients showed hypercalciuria, 34% hyperoxaluria, 34% hypocitraturia and 7% hyperuricosuria. Statistically significant differences were observed only in fasting calcium/creatinine ratio (0.17 vs. 0.08; P<.0001) when comparing patients with hypercalciuria with those with normocalciuria.
  
  
  CONCLUSIONS
  Patients with osteoporotic fractures show different lithogenic factors in urine, mainly hypercalciuria, always in fasting conditions.
authors.affiliation: Servicio de Cirugía, Ortopedia y Traumatología, Hospital Rafael Méndez, Lorca, España.
authors.forename: M Á
authors.initials: MÁ
authors.lastname: Ochoa-Hortal Rull
authors.affiliation: UGC Urología Intercentros, Hospital La Inmaculada, Huércal Overa, España.
authors.forename: M C
authors.initials: MC
authors.lastname: Cano-García
authors.affiliation: UGC Urología Intercentros, Hospital San Cecilio, Granada, España.
authors.forename: M
authors.initials: M
authors.lastname: Arrabal Martín
authors.affiliation: Servicio de Cirugía, Ortopedia y Traumatología, Hospital Rafael Méndez, Lorca, España.
authors.forename: R
authors.initials: R
authors.lastname: Cano Gea
authors.affiliation: Servicio de Endocrinología y Nutrición Clínica, Hospital Rafael Méndez, Lorca, España.
authors.forename: R
authors.initials: R
authors.lastname: Reyes García
authors.affiliation: UGC Urología Intercentros, Hospital La Inmaculada, Huércal Overa, España. Electronic address: arrabalp@ono.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Arrabal-Polo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000652:urine; D002118:Calcium / Q000378:metabolism*; D019343:Citric Acid / Q000652:urine; D005215:Fasting / Q000652:urine; D005260:Female; D006801:Humans; D053565:Hypercalciuria / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000378:metabolism*; D058866:Osteoporotic Fractures / Q000209:etiology / Q000601:surgery / Q000652:urine*; D010281:Parathyroid Hormone / Q000652:urine; D010758:Phosphorus / Q000378:metabolism*; D012307:Risk Factors; D014527:Uric Acid / Q000652:urine; D052878:Urolithiasis / Q000209:etiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000652:urine
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; D014527:Uric Acid; D010758:Phosphorus; D019343:Citric Acid; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: Factores litogénicos; Fasting hypercalciuria; Fractura osteoporótica; Hipercalciuria de ayunas; Lithogenic factors; Osteoporosis; Osteoporotic fracture