title: Comparison of vaginal misoprostol and dinoprostone for cervical ripening before diagnostic hysteroscopy in nulliparous women.
abstract: OBJECTIVE
  To compare the effectiveness of vaginal misoprostol and dinoprostone for cervical ripening before diagnostic hysteroscopy in nulliparous women.
  
  
  METHODS
  Placebo-controlled, double blind, randomized trial.
  
  
  METHODS
  Teaching and research hospital.
  
  
  METHODS
  Ninety women of reproductive age eligible for diagnostic hysteroscopy.
  
  
  METHODS
  Randomly assignment to receive 400 μg of misoprostol (n = 30) or 10 mg of dinoprostone (n = 30) vaginally before diagnostic hysteroscopy, with a control group (n = 30) not receiving any cervical priming agent.
  
  
  METHODS
  
  
  
  METHODS
  the number of women requiring cervical dilatation; secondary outcomes: cervical width before surgery, duration of dilatation time, ease of dilatation, complications during surgical procedure, and side effects of the drugs.
  
  
  RESULTS
  In the placebo group, 23 patients required cervical dilatation compared with 17 in the misoprostol group and 9 in the dinoprostone group. The mean (± standard deviation) cervical widths for the placebo, misoprostol, and dinoprostone groups were 4.23 ± 0.43 mm, 5.43 ± 0.5 mm, and 5.83 ± 0.64 mm, respectively. These widths were statistically significantly different. The duration of dilatation was also statistically significantly longer in the control group.
  
  
  CONCLUSIONS
  Vaginally administered dinoprostone before diagnostic hysteroscopy is more effective than misoprostol for inducing cervical priming. Further studies are required to elucidate the most efficient option with the least side effects for cervical ripening.
  
  
  BACKGROUND
  NCT01620814.
authors.affiliation: Konya Education and Research Hospital, Konya, Turkey. Electronic address: dr.hasanaliinal@yahoo.com.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: Inal
authors.affiliation: Konya Education and Research Hospital, Konya, Turkey.
authors.forename: Zeynep Hafiza
authors.initials: ZH
authors.lastname: Ozturk Inal
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Tonguc
authors.affiliation: Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Var
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D020070:Cervical Ripening / Q000187:drug effects*; D004106:Dilatation; D015232:Dinoprostone / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage* / Q000009:adverse effects; D010298:Parity; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D014421:Turkey; D014591:Uterine Diseases / Q000175:diagnosis*
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D015232:Dinoprostone
keywords: Cervical ripening; dinoprostone; hysteroscopy; misoprostol