title: Common variable immune deficiency in a Pomeranian with Pneumocystis carinii pneumonia.
abstract: A Pomeranian dog, 1 year- and 8 month-old neutered female, was presented with persistent respiratory distress and recurrent generalized demodicosis. Physical examination revealed cyanosis, rough respiratory sounds, multifocal alopecia and dermal erosions on the dorsal side of the forelimbs, perineal area and skin around the eyes. A severe diffuse interstitial lung pattern was observed on thoracic radiographs. The blood examination revealed neutrophilia and hypoglobulinemia. Serum immunoglobulin concentrations of IgG and IgA were low. Histopathological examination revealed severe diffuse interstitial pneumonia with Pneumocystis carinii infection. Severe lymphoid depletion was observed in the spleen and other organs with lymphoid follicles consisted mainly of CD3-positive T cells and few cells of B-cell lineage. B-cell hypoplasia with subsequent antibody deficiency was suspected.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanemoto
authors.forename: Rei
authors.initials: R
authors.lastname: Morikawa
authors.forename: James Kenn
authors.initials: JK
authors.lastname: Chambers
authors.forename: Koichi
authors.initials: K
authors.lastname: Kasahara
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hanafusa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D017074:Common Variable Immunodeficiency / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology*; D004285:Dogs; D005260:Female; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007150:Immunohistochemistry / Q000662:veterinary; D008168:Lung / Q000473:pathology; D008969:Molecular Sequence Data; D010802:Phylogeny; D045363:Pneumocystis carinii / Q000235:genetics; D011020:Pneumonia, Pneumocystis / Q000473:pathology / Q000662:veterinary*; D012335:RNA, Ribosomal / Q000235:genetics; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000276:immunology / Q000473:pathology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012335:RNA, Ribosomal