title: Associations between IGF-I, IGF-binding proteins and bone turnover markers in prepubertal obese children.
abstract: OBJECTIVE
  To assess the relationships between components of the growth hormone axis, body composition, and bone markers in obese children.
  
  
  METHODS
  We determined the levels of bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), insulin-like growth factor-I (IGF-I), and IGF-binding proteins (IGFBPs) by immunoenzymatic methods, and body composition by dual-energy X-ray absorptiometry in 45 obese and 20 non-obese children.
  
  
  RESULTS
  IGF-I and functional IGFBP-3 levels, IGF-I/total IGFBP-3, and functional IGFBP-3/total IGFBP-3 molar ratios were significantly higher in obese patients than in controls. Multivariate regression analysis in obese patients showed significant associations of BALP with IGF-I (p=0.047) and percent of body fat mass (p=0.002).
  
  
  CONCLUSIONS
  The relationship of IGF-I and functional IGFBP-3 to BALP may support the concept of IGF-I influence on accelerated bone formation process in obesity. Moreover, IGF-I and percentage of body fat mass may be significant predictors of BALP in obese during the prepubertal period.
authors.forename: Joanna
authors.initials: J
authors.lastname: Gajewska
authors.forename: Witold
authors.initials: W
authors.lastname: Klemarczyk
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Ambroszkiewicz
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szamotulska
authors.forename: Magdalena
authors.initials: M
authors.lastname: Chełchowska
authors.forename: Halina
authors.initials: H
authors.lastname: Weker
mesh_terms: D015502:Absorptiometry, Photon; D000886:Anthropometry; D015415:Biomarkers / Q000378:metabolism*; D016723:Bone Remodeling; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000378:metabolism*; D011627:Puberty
chemical_list: D015415:Biomarkers; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I