title: Tipping the metabolic scales towards increased longevity in mammals.
abstract: A hallmark of ageing is dysfunction in nutrient signalling pathways that regulate glucose homeostasis, negatively affecting whole-body energy metabolism and ultimately increasing the organism's susceptibility to disease. Maintenance of insulin sensitivity depends on functional mitochondrial networks, but is compromised by alterations in mitochondrial energy metabolism during ageing. Here we discuss metabolic paradigms that influence mammalian longevity, and highlight recent advances in identifying fundamental signalling pathways that influence metabolic health and ageing through mitochondrial perturbations.
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
authors.forename: Celine E
authors.initials: CE
authors.lastname: Riera
authors.affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dillin
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000235:genetics*; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D008136:Longevity / Q000235:genetics*; D008659:Metabolic Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D056811:Unfolded Protein Response
chemical_list: D007328:Insulin; D024101:Mitochondrial Proteins; D005947:Glucose