title: The effect of aging on sequestration and bioaccessibility of oxytetracycline in soils.
abstract: Veterinary antibiotics introduced into soil environment may change the composition and functioning of soil microbial communities and promote the spreading of antibiotic resistance. Actual risks depend on the antibiotic's bioaccessibility and sequestration in soils, which may vary with contact time and soil properties. We elucidated changes in the horsebean plant's bioaccessible oxytetracycline with increasing contact time in three different soils (cinnamon, red, and brown soil) and observed discrepancy in oxytetracycline dissipation using sequential extractions with H2O-, 0.01 M CaCl2-, and Mcllvaine- in the same three soils. The results showed lower quantities of oxytetracycline with increasing contact time over 20 days than the level in freshly contaminated soils but hugely discrepant quantities among the three tested soils. In addition, aging largely reduced dissipation of H2O-, 0.01 M CaCl2-, and Mcllvaine- extracted oxytetracycline in soils before planting. However, bioturbation helped increase the H2O-, CaCl2-, and Mcllvaine- extracted oxytetracyline from cinnamon and brown soils with aging. Lastly, correlation analysis indicated that bioaccessibility of oxytetracycline significantly correlates with the total of H2O-, CaCl2-, and Mcllvaine- extracted oxytetracycline (0.676**, p < 0.01) in soils, especially the H2O- (0.789**, p < 0.01) and Mcllvaine- (0.686**, p < 0.01) extracted oxytetracycline with aging. Overall, this study provides some basic understanding of the aging effect on sequestration and bioaccessibility of veterinary antibiotics in soils.
authors.affiliation: Key Laboratory of Pollution Processes and Environmental Criteria, Ministry of Education/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, People's Republic of China.
authors.forename: Yuxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Bao
authors.forename: Zhang
authors.initials: Z
authors.lastname: Cai
authors.forename: Zhenzihao
authors.initials: Z
authors.lastname: Zhang
authors.forename: Peilin
authors.initials: P
authors.lastname: Cao
authors.forename: Xinqian
authors.initials: X
authors.lastname: Li
authors.forename: Qixing
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry*; D004355:Drug Stability; D004787:Environmental Pollution; D006207:Half-Life; D010118:Oxytetracycline / Q000032:analysis / Q000737:chemistry*; D012987:Soil / Q000737:chemistry; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000032:analysis / Q000737:chemistry*; D019155:Veterinary Drugs / Q000032:analysis / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D012987:Soil; D012989:Soil Pollutants; D019155:Veterinary Drugs; D010118:Oxytetracycline