title: The relationship between coagulation state and inflammatory bowel disease: current understanding and clinical implications.
abstract: Inflammatory bowel disease (IBD) is associated with a hypercoagulable state and subsequently with an increased risk for venous thromboembolism (VTE). VTE in IBD is characterized by a high recurrence rate and is associated with the disease activity. Acquired endothelial dysfunction, abnormalities of platelets, activation of coagulation system and impaired fibrinolysis are the main changes in the coagulation state in IBD. The development of VTE in IBD has been considered to be the result of multiple interactions between acquired and inherited risk factors. The treatment of VTE in IBD patients is recommended to be similar and to follow the same protocols as for non-IBD patients. In the clinical practice, the management of IBD patients and especially the hospitalized patients should include thromboprophylaxis.
authors.affiliation: Department of Gastroenterology, University Hospital Heraklion, P.O. Box 1352, 71110 Heraklion, Crete, Greece.
authors.forename: Ioannis E
authors.initials: IE
authors.lastname: Koutroubakis
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood / Q000453:epidemiology*; D001792:Blood Platelets / Q000502:physiology*; D059647:Gene-Environment Interaction; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000453:epidemiology*; D012306:Risk; D015912:Thrombolytic Therapy; D054556:Venous Thromboembolism / Q000097:blood / Q000453:epidemiology*
keywords: Crohn’s disease; angiogenesis; factor V Leiden; homocysteine; ulcerative colitis; venous thromboembolism