title: Anti-cancer agents derived from solid-state fermented Antrodia camphorata mycelium.
abstract: Three new ubiquinone derivatives, antrocamol LT1, antrocamol LT2, and antrocamol LT3, along with two known compounds, were isolated from Antrodia camphorata (Polyporaceae) mycelium. The structures of these compounds were established on the basis of extensive 1D and 2D NMR spectroscopic analyses. These ubiquinones exhibited selective cytotoxicities against five human cancer cell lines (CT26, A549, HepG2, PC3 and DU-145) with IC50 values ranging from 0.01 to 1.79μΜ.
authors.affiliation: Graduate Institute of Medical Science, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC; School of Pharmacy, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC.
authors.forename: I-Chuan
authors.initials: IC
authors.lastname: Yen
authors.affiliation: Department of Pathology, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan, ROC.
authors.forename: Chen-Wen
authors.initials: CW
authors.lastname: Yao
authors.affiliation: LanTyng Biotech, Co., Ltd. Taipei, Taiwan, ROC.
authors.forename: Mao-Tien
authors.initials: MT
authors.lastname: Kuo
authors.affiliation: Graduate Institute of Life Science, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC.
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Chao
authors.affiliation: Department of Pathology, Tri-Service General Hospital, No. 325, Sec. 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan, ROC.
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Pai
authors.affiliation: School of Pharmacy, National Defense Medical Center, No. 161, Sec. 6, Minchuan East Road, Neihu District, Taipei City 114, Taiwan, ROC. Electronic address: wlchang@mail.ndmctsgh.edu.tw.
authors.forename: Wen-Liang
authors.initials: WL
authors.lastname: Chang
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D055491:Antrodia / Q000737:chemistry*; D045744:Cell Line, Tumor; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; C000598389:antrocamol; D014451:Ubiquinone
keywords: Antrocamol LT1; Antrocamol LT2; Antrocamol LT3; Antrodia camphorata; Cytotoxicity; Ubiquinone derivative