title: Epigenetic mechanisms of induced pluripotency.
abstract: Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.
authors.affiliation: Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Gładych
authors.affiliation: Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
authors.forename: Anastazja
authors.initials: A
authors.lastname: Andrzejewska
authors.affiliation: Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland ; Laboratory of Gene Therapy, Department of Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Oleksiewicz
authors.affiliation: Department of Molecular Carcinogenesis, Division of Basic Science Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Marcos R H
authors.initials: MR
authors.lastname: Estécio
keywords: DNA methylation; chromatin modifications; epigenetics; induced pluripotent stem cells