title: Number of sons contributes to ageing-associated inflammation.
abstract: The rate of inflammation increases in elderly individuals, a phenomenon called inflammaging, and is associated with degenerative diseases. However, the causes of inflammaging and the origin of the associated inflammatory mediators have remained enigmatic. We show herein that there is a positive correlation between the number of sons born and C-reactive protein concentrations in 90-year-old women. This association is influenced by HLA genetics known to regulate the immune response against HY antigens.
authors.affiliation: 1] Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland [2] Gerontology Research Center, Tampere, Finland.
authors.forename: Saara
authors.initials: S
authors.lastname: Marttila
authors.affiliation: 1] Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland [2] Gerontology Research Center, Tampere, Finland.
authors.forename: Tapio
authors.initials: T
authors.lastname: Nevalainen
authors.affiliation: 1] Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland [2] Gerontology Research Center, Tampere, Finland.
authors.forename: Laura
authors.initials: L
authors.lastname: Kananen
authors.affiliation: 1] Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland [2] Gerontology Research Center, Tampere, Finland.
authors.forename: Juulia
authors.initials: J
authors.lastname: Jylhävä
authors.affiliation: 1] Gerontology Research Center, Tampere, Finland [2] School of Health Sciences, University of Tampere, Tampere, Finland.
authors.forename: Marja
authors.initials: M
authors.lastname: Jylhä
authors.affiliation: 1] Gerontology Research Center, Tampere, Finland [2] School of Health Sciences, University of Tampere, Tampere, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Hervonen
authors.affiliation: 1] Immunogenetics Laboratory, University of Turku, Turku, Finland [2] Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland.
authors.forename: Jorma
authors.initials: J
authors.lastname: Ilonen
authors.affiliation: 1] Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland [2] Gerontology Research Center, Tampere, Finland [3] Fimlab Laboratories, Tampere, Finland.
authors.forename: Mikko
authors.initials: M
authors.lastname: Hurme
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000276:immunology; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006182:H-Y Antigen / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000235:genetics; D009679:Nuclear Family; D010298:Parity; D055815:Young Adult
chemical_list: D006182:H-Y Antigen; D015395:Histocompatibility Antigens Class I; D002097:C-Reactive Protein