title: Systemic Radiopharmaceutical Agents (Sm-153) may be Dangerous in Hepatacellular Carcinoma.
abstract: Palliation of bone metastases in hepatocellular carcinoma (HCC) is sometimes difficult. Systemic pharmaceuticals have been successfully used for the palliation of bone metastasis for many years. Safety of these agents in HCC is not known completely. We presented a male patient with decompensated liver cirrhosis with HCC. Multifocal bone metastases developed in this patient and he had refractory bone pain. We treated this patient with Sm-153 (samarium) after obtaining patient's consent. Two days after treatment, he experienced dyspnea and we detected a massive hemorrhagic pericardial effusion. He died due to this unexpected bleeding. We should use this radiopharmaceutical treatment cautiously in these cytopenic cirrhotic patients.
authors.affiliation: Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Keskin
authors.affiliation: Department of Nuclear Medicine, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Soydal
authors.affiliation: Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Xheni
authors.initials: X
authors.lastname: Deda
authors.affiliation: Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Bengu
authors.initials: B
authors.lastname: Manti
authors.affiliation: Department of Gastroenterology, School of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Tuzun
keywords: Bone metastasis; Sm-153; hepatocellular carcinoma