title: Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma.
abstract: OBJECTIVE
  This is the final report of a phase III randomized study to evaluate whole-brain radiotherapy (WBRT) in primary therapy of primary CNS lymphoma (PCNSL) after a median follow-up of 81.2 months.
  
  
  METHODS
  Patients with newly diagnosed PCNSL were randomized to high-dose methotrexate (HDMTX)-based chemotherapy alone or followed by WBRT. We hypothesized that the omission of WBRT would not compromise overall survival (OS; primary endpoint), using a noninferiority design with a margin of 0.9.
  
  
  RESULTS
  In the per-protocol population (n = 320), WBRT nonsignificantly prolonged progression-free survival (PFS) (median 18.2 vs 11.9 months, hazard ratio [HR] 0.83 [95% confidence interval (CI) 0.65-1.06], p = 0.14) and significantly PFS from last HDMTX (25.5 vs 12.0 months, HR 0.65 [95% CI 0.5-0.83], p = 0.001), but without OS prolongation (35.6 vs 37.1 months, HR 1.03 [95% CI 0.79-1.35], p = 0.82). In the intent-to-treat population (n = 410), there was a prolongation by WBRT of both PFS (15.4 vs 9.9 months, HR 0.79 [95% CI 0.64-0.98], p = 0.034) and PFS from last HDMTX (19.4 vs 11.9 months, HR 0.72 [95% CI 0.58-0.89], p = 0.003), but not of OS (32.4 vs 36.1 months, HR 0.98 [95% CI 0.79-1.26], p = 0.98).
  
  
  CONCLUSIONS
  Although the statistical proof of noninferiority regarding OS was not given, our results suggest no worsening of OS without WBRT in primary therapy of PCNSL.
  
  
  METHODS
  This study provides Class II evidence that in PCNSL HDMTX-based chemotherapy followed by WBRT does not significantly increase survival compared to chemotherapy alone. The study lacked the precision to exclude an important survival benefit or harm from WBRT.
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany. agnieszka.korfel@charite.de.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korfel
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thiel
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Martus
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Möhle
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Griesinger
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Rauch
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Röth
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Bernd
authors.initials: B
authors.lastname: Hertenstein
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fischer
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hundsberger
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Hans G
authors.initials: HG
authors.lastname: Mergenthaler
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Junghanß
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Birnbaum
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Fischer
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Kristoph
authors.initials: K
authors.lastname: Jahnke
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Herrlinger
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Roth
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bamberg
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Pietsch
authors.affiliation: From the Department of Hematology, Oncology and Tumor Immunology (A.K., E.T., L.F., K.J.), Charité Berlin; the Departments of Clinical Epidemiology and Applied Biostatistics (P.M.) and Hematology and Oncology (R.M.), University Tübingen; the Department of Radiotherapy and Medical Oncology (F.G.), Pius Hospital Oldenburg; the Department of Neurology (M.R.), Protestant Hospital Bielefeld; the Department of Hematology (A.R.), University Hospital Essen; the Department of Internal Medicine (B.H.), Hospital Bremen Center; the Department of Hematology and Oncology (T.F.), University Hospital Magdeburg; the Department of Neurology (T.H.), University Hospital Mainz; the Department of Hematology and Oncology (H.G.M.), Klinikum Stuttgart; the Department of Hematology and Oncology (C.J.), University Hospital Rostock; the Department of Neurology (T.B.), University Hospital Munich LMU; the Departments of Neurology (U.H., P.R., M.W.) and Radiation Oncology (M.B.), University Hospital Tübingen; the Department of Neurology (U.H.), University Bonn, Germany; the Department of Neurology (P.R., M.W.), University Hospital Zurich, Switzerland; and the Institute of Neuropathology (T.P.), University Hospital Bonn, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D024221:Antineoplastic Protocols; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation / Q000379:methods*; D018572:Disease-Free Survival; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate