title: Olive Leaf Extract Elevates Hepatic PPAR α mRNA Expression and Improves Serum Lipid Profiles in Ovariectomized Rats.
abstract: We hypothesized that olive leaf extract might alleviate dyslipidemia resulting from estrogen deficiency. Serum lipid profile and mRNA expression of the related genes in the liver and adipose tissue were analyzed after providing olive leaf extract (200 or 400 mg/kg body weight; n=7 for each group) to ovariectomized rats for 10 weeks. After 10 weeks' administration, the rats in the olive leaf extract-administered groups showed significantly lower levels of serum triglyceride and very-low-density lipoprotein (VLDL)-cholesterol compared with the rats in the control group, whereas the administration of olive leaf extract did not significantly change the elevated low-density lipoprotein cholesterol levels. In addition, administration of high dose of olive leaf extract significantly decreased the liver triglyceride and increased serum estradiol levels. mRNA expressions of peroxisome proliferator-activated receptor alpha (PPAR α) and acyl-CoA oxidase (ACO) were not affected by ovariectomy, however, administration of olive leaf extract significantly increased both PPAR α and ACO mRNA expression. Expression of adiponectin mRNA in adipose tissue was significantly decreased in the ovariectomized control group. Rats administered low-dose olive leaf extract showed significantly elevated adiponectin mRNA expression compared with rats in the ovariectomized control group. Even though dose-dependent effects were not observed in most of the measurements, these results suggest that genes involved in lipid metabolism may be regulated by olive leaf extract administration in ovariectomized rats.
authors.affiliation: 1 Division of Life Systems, College of Science, Sookmyung Women's University , Seoul, Korea.
authors.forename: Leena
authors.initials: L
authors.lastname: Yoon
authors.affiliation: 2 Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University , Seoul, Korea.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Liu
authors.affiliation: 2 Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University , Seoul, Korea.|3 ICAN Nutrition Education and Research , Seoul, Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
authors.affiliation: 1 Division of Life Systems, College of Science, Sookmyung Women's University , Seoul, Korea.|2 Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University , Seoul, Korea.
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Kim
mesh_terms: D042962:Acyl-CoA Oxidase / Q000235:genetics; D052242:Adiponectin / Q000235:genetics; D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D050171:Dyslipidemias / Q000188:drug therapy; D004967:Estrogens / Q000172:deficiency; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000737:chemistry*; D031658:Olea / Q000737:chemistry*; D010052:Ovariectomy; D047493:PPAR alpha / Q000235:genetics*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D017698:Postmenopause; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D052242:Adiponectin; D004967:Estrogens; D008055:Lipids; D047493:PPAR alpha; D010936:Plant Extracts; D012333:RNA, Messenger; D042962:Acyl-CoA Oxidase
keywords: dyslipidemia; estrogen deficiency; olive leaf extract; ovariectomy; postmenopause