title: Inherited thrombophilia in pregnant women with intrauterine growth restriction.
abstract: BACKGROUND
  Intrauterine growth restriction (IUGR) is a major cause of fetal morbidity and mortality during pregnancy. The role of mutation in the factor V gene, prothrombin gene, MTHFR gene, as risk factors for intrauterine growth restriction during pregnancy, is not very well known so far.
  
  
  METHODS
  This is a retrospective study of 151 pregnant women with a history of complicated pregnancy: intrauterine growth restriction, preeclampsia, recurrent pregnancy loss or maternal venous thromboembolism, who were admitted in Bucharest Emergency University Hospital, during the period January 2010 to July 2014. Genetic testing was performed for all the cases to detect: factor V Leiden mutation, G20210A mutation in the prothrombin gene, C677T mutation and A1298C mutation in methylenetetrahydrofolate reductase (MTHFR) gene. Blood samples were obtained as soon as the diagnosis of intrauterine growth restriction was established with ultrasonography.
  
  
  RESULTS
  The following gene mutations were associated with increased risk of IUGR: G20210A prothrombin gene mutation (OR 4.81, 95% CI 1.05 - 2.22, p= 0.043), G1691A factor V gene mutation (factor V Leiden) (OR 1.58, 95% CI 0.61 - 4.080, p= 0.347), C677T MTHFR gene mutation (OR 1.61, 95% CI 0.79 to 3.26, p= 0.186), compound heterozygous MTHFR C677T and A1298C (OR 1.66, 95% CI 0.81- 3.42, p= 0.169). Particularly, for G20210A prothrombin gene mutation we found statistically significant risk (p≤0.05) of IUGR.
authors.affiliation: Emergency University Hospital, Bucharest, Romania.
authors.forename: Letitia
authors.initials: L
authors.lastname: Coriu
authors.affiliation: Emergency University Hospital, Bucharest, Romania.
authors.forename: Elena
authors.initials: E
authors.lastname: Copaciu
authors.affiliation: Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Tulbure
authors.affiliation: Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Rodica
authors.initials: R
authors.lastname: Talmaci
authors.affiliation: Emergency University Hospital, Bucharest, Romania.
authors.forename: Diana
authors.initials: D
authors.lastname: Secara
authors.affiliation: Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Daniel
authors.initials: D
authors.lastname: Coriu
authors.affiliation: Emergency University Hospital, Bucharest, Romania.
authors.forename: Monica
authors.initials: M
authors.lastname: Cirstoiu
keywords: hereditary thrombophilia; intrauterine growth restriction; pregnancy