title: [Association between inflanummatory gene polymorphisms and the risk of myocardial infarction].
abstract: Allele and genotype frequency distributions of polymorphism rs2076059 (3832T>C) within the SELE gene rs6131 (S290N), within the SELP gene, rs1131498 (F206L), within the SELL gene, rs5498 (K469E) within the ICAM1 gene, rs35569394 (-2549(18)I/D) within the VEGFA gene, and rs1024611 (-2518A>G) within the CCL2 gene were examined in a group of patients after myocardial infarction (MI)(280 individuals) and in a control group (312 individuals). An implementation of the Markov chain and Monte-Carlo method (AP- Sampler) revealed the allele combinations associated with decreased and increased risk of MI. Among these the most important allele combinations were SELE*C + SELP*S + CCL2*A (FDR = 0.0005; OR = 0.42) SELP*S + CCL2*A (FDR = 0.0009; OR= 0.36}, SELL*F + VEGFA*I+ CCL2*G/G(FDR = 0.0009; OR = 4.17) VEGFA*I+ CCL2*G/G (FDR = 0.0009; OR = 3.76), SELE*C + CCL2*A (FDR = 0.0023; OR = 0.47), and SELL*I+ CCL2*G/G (FDR = 0.003; OR = 3.15).
authors.forename: T R
authors.initials: TR
authors.lastname: Nasibullin
authors.forename: R I
authors.initials: RI
authors.lastname: Sadikova
authors.forename: Ia R
authors.initials: IaR
authors.lastname: Timasheva
authors.forename: I A
authors.initials: IA
authors.lastname: Tuktarova
authors.forename: V V
authors.initials: VV
authors.lastname: Erdman
authors.forename: L N
authors.initials: LN
authors.lastname: Khusainova
authors.forename: I E
authors.initials: IE
authors.lastname: Nikolaeva
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000235:genetics; D019040:E-Selectin / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D019041:L-Selectin / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000473:pathology; D019007:P-Selectin / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2; D019040:E-Selectin; C573420:ICAM1 protein, human; D019007:P-Selectin; C546936:SELE protein, human; C546935:SELL protein, human; C546937:SELP protein, human; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin