title: Endogenous progenitors as the source of cell material for ischemic damage repair in experimental myocardial infarction under conditions of changed concentration of vascular endothelial growth factor.
abstract: We studied the effect of VEGF-A in experimental myocardial infarction on attraction of progenitor cells into the regeneration zone. The appearance of CD34(+)CD45(+) cells known as low-differentiated progenitor cells was observed in the damaged myocardial tissue in the presence of a considerable excess of VEGF-A. These cells can act as precursors of mesenchymal tissues depending on the direction of differentiation.
authors.affiliation: Research Center of Reconstructive and Restorative Surgery, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia, shurygin@rambler.ru.
authors.forename: M G
authors.initials: MG
authors.lastname: Shurygin
authors.forename: I A
authors.initials: IA
authors.lastname: Shurygina
authors.forename: N N
authors.initials: NN
authors.lastname: Dremina
authors.forename: O V
authors.initials: OV
authors.lastname: Kanya
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D066026:Endothelial Progenitor Cells / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006321:Heart / Q000502:physiology*; D017493:Leukocyte Common Antigens / Q000378:metabolism; D008856:Microscopy, Fluorescence; D009203:Myocardial Infarction / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D017493:Leukocyte Common Antigens