title: Self-assembled micelles of amphiphilic PEGylated rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells†Electronic supplementary information (ESI) available: Chemicals and reagents, detailed experimental procedures for materials synthesis, characterization, cellular evaluations and supporting figures and tables. See DOI: 10.1039/c4tb01633eClick here for additional data file.
abstract: Self-assembled micelles of amphiphilic PEG-rapamycin conjugates loaded with paclitaxel have been developed for co-delivery and simultaneous intracellular release of paclitaxel and rapamycin, bypassing the cancer cell drug resistant mechanism and maximising the synergy of dual-drug combinational therapy. This novel nanomedicine offers 20-fold improved potency over free paclitaxel against a model multidrug resistant human breast cancer cell.
authors.affiliation: School of Pharmacy , Shanghai Jiao Tong University , Shanghai , 200240 , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.affiliation: School of Pharmacy , Shanghai Jiao Tong University , Shanghai , 200240 , China.
authors.forename: Jieying
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Chemistry and Asbury Centre for Structural Molecular Biology , University of Leeds , Leeds , LS2 9JT , UK . Email: d.zhou@leeds.ac.uk ; Email: s.guo@leeds.ac.uk ; Email: srguo@sjtu.edu.cn ; Tel: +44 (0)113 3436230 ; Tel: +44 (0)113 3436449.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: School of Pharmacy , Shanghai Jiao Tong University , Shanghai , 200240 , China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Chemistry and Asbury Centre for Structural Molecular Biology , University of Leeds , Leeds , LS2 9JT , UK . Email: d.zhou@leeds.ac.uk ; Email: s.guo@leeds.ac.uk ; Email: srguo@sjtu.edu.cn ; Tel: +44 (0)113 3436230 ; Tel: +44 (0)113 3436449.
authors.forename: Dejian
authors.initials: D
authors.lastname: Zhou
authors.affiliation: School of Pharmacy , Shanghai Jiao Tong University , Shanghai , 200240 , China ; School of Chemistry and Asbury Centre for Structural Molecular Biology , University of Leeds , Leeds , LS2 9JT , UK . Email: d.zhou@leeds.ac.uk ; Email: s.guo@leeds.ac.uk ; Email: srguo@sjtu.edu.cn ; Tel: +44 (0)113 3436230 ; Tel: +44 (0)113 3436449.
authors.forename: Shengrong
authors.initials: S
authors.lastname: Guo