title: Pemphigoid with antibodies to laminin γ1, BP180 and BP230, associated with psoriasis vulgaris: successful disease control with cyclosporin.
abstract: Both anti-laminin γ1 pemphigoid and bullous pemphigoid are autoimmune subepidermal blistering diseases. The former is rare and characterized by autoantibodies to laminin γ1, a 200-kDa dermal protein, while the latter is common among the elderly and characterized by autoantibodies to BP180 and BP230, both of which are hemidesmosomal proteins. We experienced a 69-year-old Japanese male patient with blister formation secondary to erythrodermic psoriasis, which was successfully treated with cyclosporin. The histopathology of erythema corresponded with psoriasis and that of a blistering lesion showed infiltration of neutrophils and eosinophils in and around the subepidermal blisters. Patient immunoglobulin G antibodies labeled both the epidermal and dermal sides of 1 mol/L NaCl-split human skin by indirect immunofluorescent microscopy and recognized laminin γ1, BP180 and BP230 by immunoblotting. To the best of our knowledge, this is the first report of coexistence of psoriasis and atypical pemphigoid with these three autoantibodies.
authors.affiliation: Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Imanishi
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tateishi
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Imanishi
authors.forename: Junko
authors.initials: J
authors.lastname: Sowa-Osako
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koga
authors.forename: Daisuke
authors.initials: D
authors.lastname: Tsuruta
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000378:metabolism; D001324:Autoantigens / Q000276:immunology; D016572:Cyclosporine / Q000627:therapeutic use*; D000071821:Dystonin / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007797:Laminin / Q000276:immunology; D008297:Male; D024041:Non-Fibrillar Collagens / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D000097805:Collagen Type XVII
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D016572:Cyclosporine; D000071821:Dystonin; D007166:Immunosuppressive Agents; D007797:Laminin; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human; C089141:laminin gamma 1
keywords: BP180; cyclosporin; laminin γ1; pemphigoid; psoriasis