title: Transition-metal-free decarboxylation of dimethyl malonate: an efficient construction of α-amino acid esters using TBAI/TBHP.
abstract: A transition-metal-free decarboxylation coupling process for the preparation of α-amino acid esters, which succeeded in merging hydrolysis/decarboxylation/nucleophilic substitution, is well described. This strategy uses commercially available inexpensive starting materials, catalysts and oxidants and has a wide substrate scope and operational simplicity.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Renai Road, 215123 Suzhou, China. xdm.sd@163.com wanxb@suda.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Shao
authors.forename: Yaxiong
authors.initials: Y
authors.lastname: Wang
authors.forename: Huihuang
authors.initials: H
authors.lastname: Li
authors.forename: Dongmei
authors.initials: D
authors.lastname: Xu
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wan
mesh_terms: D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D004952:Esters; D008314:Malonates / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry; D010545:Peroxides / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D000596:Amino Acids; D004952:Esters; D008314:Malonates; D016877:Oxidants; D010545:Peroxides; D000644:Quaternary Ammonium Compounds; C005230:methyl malonate; C000602361:tert-butyl peroxide