title: Structure of a left-handed DNA G-quadruplex.
abstract: Aside from the well-known double helix, DNA can also adopt an alternative four-stranded structure known as G-quadruplex. Implications of such a structure in cellular processes, as well as its therapeutic and diagnostic applications, have been reported. The G-quadruplex structure is highly polymorphic, but so far, only right-handed helical forms have been observed. Here we present the NMR solution and X-ray crystal structures of a left-handed DNA G-quadruplex. The structure displays unprecedented features that can be exploited as unique recognition elements.
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and.
authors.forename: Wan Jun
authors.initials: WJ
authors.lastname: Chung
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and.
authors.forename: Brahim
authors.initials: B
authors.lastname: Heddi
authors.affiliation: Laboratoire de Biochimie, UMR 7654, CNRS, Ecole Polytechnique, Palaiseau 91128, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Schmitt
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and.
authors.forename: Kah Wai
authors.initials: KW
authors.lastname: Lim
authors.affiliation: Laboratoire de Biochimie, UMR 7654, CNRS, Ecole Polytechnique, Palaiseau 91128, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Mechulam
authors.affiliation: School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore; and phantuan@ntu.edu.sg.
authors.forename: Anh Tuân
authors.initials: AT
authors.lastname: Phan
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA
keywords: G-quadruplex; NMR; X-ray crystallography; left-handed helix; nucleic acid