title: [Effect glutargin in blinding function of serum albumin and other indicators of functional state of liver in acute toxic alcoholic hepatitis].
abstract: Acute toxic alcoholic hepatitis continue to be relevant problem of modern medicine as a result of a significant spread of alcoholism in Ukraine and world. Aim - to explore the effect glutargin in blinding function of serum albumin and other indicators of functional state of liver in acute alcoholic toxic hepatitis in experiments on white rats. All animals were divided into four groups. The first (control group) consisted of 20 healthy intact animals, second - 17 rats with acute toxic alcoholic hepatitis, which was taken out of the experiment on the second day of its commencement, the third - 16 animals with similarly modeled pathology, which was taken out on the seventh day from the beginning of the experiment, fourth - 20 animals with acute toxic alcoholic hepatitis, which underwent correction of 4.0% solution glutargin during seven days. Shown, that blinding function of serum albumin, reduced in conditions studied pathology, take place pronounced biochemical signs of liver parenchyma. Under the influence of glutargin studied parameters significantly improved. In acute toxic alcoholic hepatitis significantly disturbing protein-synthetic liver function, occur phenomena cytolysis, suppressed blinding function of serum albumin with maximum expression on the second day of the experiment and with signs of recovery on the seventh day. Under the influence of glutargin upgraded indicators of blinding function of serum albumin: total protein, aminotransferase, alkaline phosphatase, total bilirubin. The activity of serum aspartate aminotransferase normalized and reached the level of control.
authors.forename: S M
authors.initials: SM
authors.lastname: Andeychyn
authors.forename: Z S
authors.initials: ZS
authors.lastname: Skirak
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D000431:Ethanol / Q000633:toxicity; D018698:Glutamic Acid / Q000008:administration & dosage*; D006519:Hepatitis, Alcoholic / Q000097:blood / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D011485:Protein Binding / Q000187:drug effects*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism*; D014455:Ukraine
chemical_list: D012709:Serum Albumin; D000431:Ethanol; D018698:Glutamic Acid; D001120:Arginine; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D001663:Bilirubin