title: Impact of body mass index on long-term clinical outcomes after second-generation drug eluting stent implantation: Insights from the international global RESOLUTE program.
abstract: BACKGROUND
  An increased body mass index (BMI) is associated with a high risk of cardiovascular disease and reduction in life expectancy. However, several studies reported improved clinical outcomes in obese patients treated for cardiovascular diseases. The aim of the present study is to investigate the impact of BMI on long-term clinical outcomes after implantation of zotarolimus eluting stents.
  
  
  METHODS
  Individual patient data were pooled from the RESOLUTE Clinical Program comprising five trials worldwide. The study population was sorted according to BMI tertiles and clinical outcomes were evaluated at 2-year follow-up.
  
  
  RESULTS
  Data from a total of 5,127 patients receiving the R-ZES were included in the present study. BMI tertiles were as follow: I tertile (≤ 25.95 kg/m(2) -Low or normal weight) 1,727 patients; II tertile (>25.95 ≤ 29.74 kg/m(2) -overweight) 1,695 patients, and III tertile (>29.74 kg/m(2) -obese) 1,705 patients. At 2-years follow-up no difference was found for patients with high BMI (III tertile) compared with patients with normal or low BMI (I tertile) in terms of target lesion failure (I-III tertile, HR [95% CI] = 0.89 [0.69, 1.14], P = 0.341; major adverse cardiac events (I-III tertile, HR [95% CI] = 0.90 [0.72, 1.14], P = 0.389; cardiac death (I-III tertile, HR [95% CI] = 1.20 [0.73, 1.99], P = 0.476); myocardial infarction (I-III tertile, HR [95% CI] = 0.86 [0.55, 1.35], P = 0.509; clinically-driven target lesion revascularization (I-III tertile, HR [95% CI] = 0.75 [0.53, 1.08], P = 0.123; definite or probable stent thrombosis (I-III tertile, HR [95% CI] = 0.98 [0.49, 1.99], P = 0.964.
  
  
  CONCLUSIONS
  In the present study, the patients' body mass index was found to have no impact on long-term clinical outcomes after coronary artery interventions.
authors.affiliation: Department of Interventional Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Roberto
authors.initials: R
authors.lastname: Diletti
authors.forename: Hector M
authors.initials: HM
authors.lastname: Garcia-Garcia
authors.forename: Christos
authors.initials: C
authors.lastname: Bourantas
authors.forename: Nicolas M
authors.initials: NM
authors.lastname: Van Mieghem
authors.forename: Robert Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramatsu
authors.forename: Yao-Jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Laura
authors.initials: L
authors.lastname: Mauri
authors.forename: Jorge
authors.initials: J
authors.lastname: Belardi
authors.forename: Sigmund
authors.initials: S
authors.lastname: Silber
authors.forename: Petr
authors.initials: P
authors.lastname: Widimsky
authors.forename: Martin
authors.initials: M
authors.lastname: Leon
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Ian
authors.initials: I
authors.lastname: Meredith
authors.forename: Franz-Josef
authors.initials: FJ
authors.lastname: Neumann
authors.forename: Alan C
authors.initials: AC
authors.lastname: Yeung
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.forename: Minglei
authors.initials: M
authors.lastname: Liu
authors.forename: Frank
authors.initials: F
authors.lastname: van Leeuwen
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods / Q000401:mortality*; D015992:Body Mass Index; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D016208:Databases, Factual; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D038622:Internationality; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus
keywords: coronary artery disease; obesity paradox; zotarolimus eluting stents