title: Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.
abstract: The Nature in 2010 (Ricci-Vitiani et al., 2010). The experiments that will be replicated are those reported in Figure 4B and Supplementary Figure 10B (Ricci-Vitiani et al., 2010), which demonstrate that glioblastoma stem-like cells can derive into endothelial cells, and can be selectively ablated to reduce tumor progression in vivo, and Supplementary Figures S10C and S10D (Ricci-Vitiani et al., 2010), which demonstrate that fully differentiated glioblastoma cells cannot form functionally relevant endothelium. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
authors.affiliation: Noble Life Sciences, Gaithersburg, Maryland, United States.
authors.forename: Denise
authors.initials: D
authors.lastname: Chroscinski
authors.affiliation: BioFactura, Frederick, Maryland, United States.
authors.forename: Darryl
authors.initials: D
authors.lastname: Sampey
authors.affiliation: Harvard Stem Cell Institute, Cambridge, Massachusetts, United States.
authors.forename: Nimet
authors.initials: N
authors.lastname: Maherali
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology*; D004727:Endothelium / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000098:blood supply / Q000473:pathology*; D064593:Heterografts; D006801:Humans; D051379:Mice; D014411:Neoplastic Stem Cells / Q000473:pathology*
keywords: Reproducibility Project: Cancer Biology; cancer stem cells; developmental biology; endothelium; glioblastoma multiforme; human biology; medicine; methodology; mouse; stem cells