title: Newborn meconium and urinary metabolome response to maternal gestational diabetes mellitus: a preliminary case-control study.
abstract: Recently, the number of women suffering from gestational diabetes mellitus (GDM) has risen dramatically. GDM attracts increasing attention due to its potential harm to the heath of both the fetus and the mother. We designed this case-control study to investigate the metabolome response of newborn meconium and urine to maternal GDM. GDM mothers (n = 142) and healthy controls (n = 197) were recruited during June-July 2012 in Xiamen, China. The newborns' metabolic profiles were acquired using liquid chromatography coupled to mass spectrometry. The data showed that meconium and urine metabolome patterns clearly discriminated GDM cases from controls. Fourteen meconium metabolic biomarkers and three urinary metabolic biomarkers were tentatively identified for GDM. Altered levels of various endogenous biomarkers revealed that GDM may induce disruptions in lipid metabolism, amino acid metabolism, and purine metabolism. An unbalanced lipid pattern is suspected to be a GDM-specific feature. Furthermore, the relationships between the potential biomarkers and GDM risk were evaluated by binary logistic regression and receiver operating characteristic analysis. A combined model of nine meconium biomarkers showed a great potential in diagnosing GDM-induced disorders.
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Peng
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Liangpo
authors.initials: L
authors.lastname: Liu
authors.affiliation: ‡Xiamen Maternity and Child Health Care Hospital, Xiamen 361003, P.R. China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Huang
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Ambreen
authors.initials: A
authors.lastname: Alamdar
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Meiping
authors.initials: M
authors.lastname: Tian
authors.affiliation: †Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, P.R. China.
authors.forename: Heqing
authors.initials: H
authors.lastname: Shen
mesh_terms: D015415:Biomarkers / Q000378:metabolism* / Q000652:urine; D016022:Case-Control Studies; D002681:China; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008470:Meconium / Q000502:physiology*; D055442:Metabolome / Q000235:genetics* / Q000502:physiology; D011247:Pregnancy; D012372:ROC Curve; D014556:Urine / Q000502:physiology*
chemical_list: D015415:Biomarkers
keywords: biomarkers; gestational diabetes mellitus; meconium; metabolomics; newborn; urine