title: [Inhibitory effect of ortho-aminoazotoluene on diethylnirtosamine hepatocarcinogenesis in suckling mice. Phenomenon and possible mechanism].
abstract: The modifying effect of the one compound on carcinogenicity of the other in the combined application is attributed usually to some changes in the carcinogen metabolism, i.e. its activation or inactivation. In this paper, when used separately, diethylnitrosamine (DENA) induced 4-6 times more neoplastic lesions in the liver of suckling mice than ortho-aminoazotoluene (OAT) did. However, after combined treatment with both carcinogens the total number of hepatic lesions was significantly lower than that in mice treated with DENA only. Similar effect was observed when OAT was administered 3 days before or 3 days after DENA injection. The observed protective effect is not mediated at metabolic level, because OAT has no effect on metabolism of DENA in mouse liver. Our findings can be unequivocally explained by the competition of the carcinogens for target protein molecules, presumably transcription factors, participating in hepatocyte differentiation, which differently interact with and are diversely impaired by different compounds.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: S I
authors.initials: SI
authors.lastname: Il'nitskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: N V
authors.initials: NV
authors.lastname: Baginskaia
authors.forename: L A
authors.initials: LA
authors.lastname: Bagdanova
authors.forename: M L
authors.initials: ML
authors.lastname: Perepechaeva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Grishanova
mesh_terms: D000477:Alkylating Agents / Q000009:adverse effects / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens / Q000494:pharmacology*; D004396:Coloring Agents / Q000009:adverse effects / Q000494:pharmacology; D004052:Diethylnitrosamine / Q000009:adverse effects* / Q000494:pharmacology; D004336:Drug Antagonism; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D009363:Neoplasm Proteins / Q000378:metabolism*; D009762:o-Aminoazotoluene / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D000477:Alkylating Agents; D002273:Carcinogens; D004396:Coloring Agents; D009363:Neoplasm Proteins; D004052:Diethylnitrosamine; D009762:o-Aminoazotoluene