title: Sirtuin inhibitor sirtinol is an intracellular iron chelator.
abstract: Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
authors.affiliation: University of Arizona, Department of Chemistry and Biochemistry, 1306 E. University Blvd., Tucson AZ 85721, USA. tomat@email.arizona.edu.
authors.forename: R
authors.initials: R
authors.lastname: Gautam
authors.forename: E A
authors.initials: EA
authors.lastname: Akam
authors.forename: A V
authors.initials: AV
authors.lastname: Astashkin
authors.forename: J J
authors.initials: JJ
authors.lastname: Loughrey
authors.forename: E
authors.initials: E
authors.lastname: Tomat
mesh_terms: D001549:Benzamides / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D005290:Ferric Compounds / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D042541:Intracellular Space / Q000737:chemistry* / Q000187:drug effects; D007502:Iron Chelating Agents / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology; D019169:Jurkat Cells; D007938:Leukemia / Q000378:metabolism / Q000473:pathology; D008958:Models, Molecular; D015394:Molecular Structure; D009284:Naphthols / Q000032:analysis* / Q000737:chemistry / Q000494:pharmacology*; D037761:Sirtuins / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D001549:Benzamides; D004791:Enzyme Inhibitors; D005290:Ferric Compounds; D007502:Iron Chelating Agents; D009284:Naphthols; C439060:sirtinol; D037761:Sirtuins