title: Impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases.
abstract: Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's, disease, as well as Paget's disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur.
authors.affiliation: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada. jacques.brown@crchul.ulaval.ca.|Division of Rheumatology, Department of Medicine, University Laval, Québec, QC, G1V 4G2, Canada. jacques.brown@crchul.ulaval.ca.
authors.forename: Mohamed Saber
authors.initials: MS
authors.lastname: Numan
authors.affiliation: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada. jacques.brown@crchul.ulaval.ca.|Division of Rheumatology, Department of Medicine, University Laval, Québec, QC, G1V 4G2, Canada. jacques.brown@crchul.ulaval.ca.|Department of Rheumatology, Centre Hospitalier Universitaire de Québec, Québec, QC, G1V 4G2, Canada. jacques.brown@crchul.ulaval.ca.
authors.forename: Jacques P
authors.initials: JP
authors.lastname: Brown
authors.affiliation: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada. laetitia.michou@crchudequebec.ulaval.ca.|Division of Rheumatology, Department of Medicine, University Laval, Québec, QC, G1V 4G2, Canada. laetitia.michou@crchudequebec.ulaval.ca.|Department of Rheumatology, Centre Hospitalier Universitaire de Québec, Québec, QC, G1V 4G2, Canada. laetitia.michou@crchudequebec.ulaval.ca.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Michou
mesh_terms: D000375:Aging / Q000187:drug effects*; D000393:Air Pollutants / Q000009:adverse effects*; D001343:Autophagy / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000393:Air Pollutants