title: Assessment of corneal thickness and tear meniscus during contact-lens wear.
abstract: OBJECTIVE
  To assess the effect of seven different daily disposable contact lenses upon corneal thickness, as well as upon tear meniscus volume, by using optical coherence tomography (OCT).
  
  
  METHODS
  Thirty-four young healthy subjects wore seven different types of daily disposable soft contact lenses, each for a period of 12h: Delefilcon A, Nelfilcon A, Omafilcon A, Filcon II3, Narafilcon A, Etafilcon A and Hilafilcon B. Central and mid-peripheral corneal thickness and lower tear meniscus volume (TMV) were measured using an OCT device during contact-lens wear at 4-h intervals throughout a 12-h period. Measurements were also recorded without any contact lenses being worn during a day.
  
  
  RESULTS
  In the no-lens scenario a small but significant (p<0.05) thinning in the cornea was observed after the 12-h period. Overall, as for contact-lens wear, it was the Hilafilcon B lens that caused the greatest thickness increase in the central area, whereas the Etafilcon A caused it in the mid-peripheral cornea. Delefilcon A was the lens that showed the most similar behavior to the naked eye. As for TMV, it decreased with all the lenses, but it was the Delefilcon A lens the one that caused the smallest drop in TMV (p=0.007).
  
  
  CONCLUSIONS
  OCT makes it possible to evaluate both corneal thickness variations and TMV changes as a result of contact-lens wear. The changes in corneal thickness hereafter presented are not clinically significant. On the other hand, TMV drop could indicate discomfort for contact-lens users.
authors.affiliation: Optometry Research Group (GIO), Department of Optics, University of Valencia, Spain. Electronic address: antonio.aguila@uv.es.
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Del Águila-Carrasco
authors.affiliation: Optometry Research Group (GIO), Department of Optics, University of Valencia, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Ferrer-Blasco
authors.affiliation: Optometry Research Group (GIO), Department of Optics, University of Valencia, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: García-Lázaro
authors.affiliation: Optometry Research Group (GIO), Department of Optics, University of Valencia, Spain.
authors.forename: José J
authors.initials: JJ
authors.lastname: Esteve-Taboada
authors.affiliation: Optometry Research Group (GIO), Department of Optics, University of Valencia, Spain.
authors.forename: Robert
authors.initials: R
authors.lastname: Montés-Micó
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D009216:Myopia / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D013499:Surface Properties; D013666:Tears / Q000737:chemistry*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: Contact lenses; Cornea; Corneal thickness; OCT; Tear meniscus volume