title: Development, evolution and pathology of neocortical subplate neurons.
abstract: Subplate neurons have an essential role in cortical circuit formation. They are among the earliest formed neurons of the cerebral cortex, are located at the junction of white and grey matter, and are necessary for correct thalamocortical axon ingrowth. Recent transcriptomic studies have provided opportunities for monitoring and modulating selected subpopulations of these cells. Analyses of mouse lines expressing reporter genes have demonstrated novel, extracortical subplate neurogenesis and have shown how subplate cells are integrated under the influence of sensory activity into cortical and extracortical circuits. Recent studies have revealed that the subplate is involved in neurosecretion and modification of the extracellular milieu.
authors.affiliation: Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
authors.forename: Anna
authors.initials: A
authors.lastname: Hoerder-Suabedissen
authors.affiliation: Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Molnár
mesh_terms: D000818:Animals; D005075:Biological Evolution; D003712:Dendrites / Q000473:pathology / Q000502:physiology; D006801:Humans; D019579:Neocortex / Q000196:embryology / Q000254:growth & development* / Q000473:pathology; D009415:Nerve Net / Q000196:embryology / Q000254:growth & development* / Q000473:pathology; D009474:Neurons / Q000473:pathology / Q000502:physiology*