title: Synthesis of pyrrolo[2,1,5-cd]indolizines through dehydrogenative Heck annelation of indolizines with diaryl acetylenes using dioxygen as an oxidant.
abstract: A dehydrogenative Heck annelation reaction of indolizine with diaryl acetylene via dual C-H bond cleavage was developed. Oxygen gas was employed as a clean oxidant in this catalysis under base-free conditions. Diarylpyrrolo[2,1,5-cd]indolizines were synthesized with high atom economy. In addition, kinetic isotope experiments provided evidence for C-H bond metalation of the 5-position of the indolizine as the rate-limiting step.
authors.affiliation: Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University , Huaian 223300, China.
authors.forename: Huayou
authors.initials: H
authors.lastname: Hu
authors.forename: Guodong
authors.initials: G
authors.lastname: Li
authors.forename: Weiming
authors.initials: W
authors.lastname: Hu
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Kan
authors.forename: Min
authors.initials: M
authors.lastname: Ji