title: Association between Tourette syndrome and the dopamine D3 receptor gene rs6280.
abstract: BACKGROUND
  Tourette syndrome (TS) is a complex, heterozygous genetic disorder. The number of molecular genetic studies have investigated several candidate genes, particularly those implicated in the dopamine system. The dopamine D3 receptor (DRD3) gene has been considered as a candidate gene in TS. There was not any report about the association study of TS and DRD3 gene in Han Chinese population. We combined a case-control genetic association analysis and nuclear pedigrees transmission disequilibrium test (TDT) analysis to investigate the association between DRD3 gene rs6280 single nucleotide polymorphisms (SNPs) and TS in a Han Chinese population.
  
  
  METHODS
  A total of 160 TS patients was diagnosed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The DRD3 gene rs6280 SNPs were genotyped by TaqMan SNP genotyping assay technique in all subjects. We used a case-control genetic association analysis to compare the difference in genotype and allele frequencies between 160 TS patients and 90 healthy controls. At the same time, we used TDT analysis to identify the DRD3 gene rs6280 transmission disequilibrium among 101 nuclear pedigrees.
  
  
  RESULTS
  The genotype and allele frequency of DRD3 gene rs6280 SNPs had no statistical difference between control group (90) and TS group (160) (χ2 = 3.647, P = 0.161; χ2 = 0.643, P = 0.423) using Chi-squared test. At the basis of the 101 nuclear pedigrees, TDT analysis showed no transmission disequilibrium of DRD3 gene rs6280 SNPs (χ2 = 0; P = 1).
  
  
  CONCLUSIONS
  Our findings provide no evidence for an association between DRD3 gene rs6280 and TS in the Han Chinese population.
authors.forename: Fan
authors.initials: F
authors.lastname: He
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Huang
authors.forename: Yu-Hang
authors.initials: YH
authors.lastname: Cheng
authors.affiliation: Department of Psychiatry, Beijing Anding Hospital, Capital Medical University; Center of Schizophrenia, Beijing Institute for Brain Disorders, Beijing 100088, China.
authors.forename: Chuan-Yue
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D050637:Receptors, Dopamine D3 / Q000235:genetics*; D005879:Tourette Syndrome / Q000209:etiology*
chemical_list: D050637:Receptors, Dopamine D3