title: A randomized, controlled, single-blind, 6-month pilot study to evaluate the efficacy of MS-Line!: a cognitive rehabilitation programme for patients with multiple sclerosis.
abstract: BACKGROUND
  MS-Line! was created to provide an effective treatment for cognitive impairment in multiple sclerosis (MS) patients.
  
  
  OBJECTIVE
  To assess the efficacy of MS-Line!.
  
  
  METHODS
  A randomized, controlled, single-blind, 6-month pilot study. Patients were randomly assigned to an experimental group (cognitive rehabilitation with the programme) or to a control group (no cognitive rehabilitation). Randomization was stratified by cognitive impairment level. Cognitive assessment included: selective reminding test, 10/36 spatial recall test (10/36 SPART), symbol digit modalities test, paced auditory serial addition test, word list generation (WLG), FAS test, subtests of WAIS-III, Boston naming test (BNT), and trail making test (TMT).
  
  
  RESULTS
  Forty-three patients (22 in the experimental group, 21 in the control group) were analyzed. Covariance analysis showed significant differences in 10/36 SPART (P=0.0002), 10/36 SPART delayed recall (P=0.0021), WLG (P=0.0123), LNS (P=0.0413), BNT (P=0.0007) and TMT-A (P=0.010) scores between groups.
  
  
  CONCLUSIONS
  The study showed a significant improvement related to learning and visual memory, executive functions, attention and information processing speed, and naming ability in those patients who received cognitive rehabilitation. The results suggest that MS-Line! is effective in improving cognitive impairment in MS patients.
authors.affiliation: Neurology Department, Dr Josep Trueta University Hospital, Girona, Spain/Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Gich
authors.affiliation: Institute of Informatics and Applications, University of Girona, Girona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Freixanet
authors.affiliation: Institute of Informatics and Applications, University of Girona, Girona, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: García
authors.affiliation: Radiology Service, Clínica Girona, Girona, Spain.
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Vilanova
authors.affiliation: Neurology Department, Dr Josep Trueta University Hospital, Girona, Spain/Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Genís
authors.affiliation: Neurology Department, Dr Josep Trueta University Hospital, Girona, Spain/Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Silva
authors.affiliation: Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
authors.affiliation: Neurology Department, Dr Josep Trueta University Hospital, Girona, Spain/Girona Biomedical Research Institute (IDIBGI), Girona, Spain llramio.girona.ics@gencat.cat.
authors.forename: Lluís
authors.initials: L
authors.lastname: Ramió-Torrentà
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000534:rehabilitation* / Q000628:therapy; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000523:psychology / Q000534:rehabilitation* / Q000628:therapy*; D009483:Neuropsychological Tests; D010865:Pilot Projects; D016037:Single-Blind Method; D055815:Young Adult
keywords: MS-Line!; Multiple sclerosis; brief repeatable battery of neuropsychological tests; cognitive impairment; cognitive rehabilitation tools; neurorehabilitation