title: Applying under-sampling techniques and cost-sensitive learning methods on risk assessment of breast cancer.
abstract: Breast cancer is one of the most common cause of cancer mortality. Early detection through mammography screening could significantly reduce mortality from breast cancer. However, most of screening methods may consume large amount of resources. We propose a computational model, which is solely based on personal health information, for breast cancer risk assessment. Our model can be served as a pre-screening program in the low-cost setting. In our study, the data set, consisting of 3976 records, is collected from Taipei City Hospital starting from 2008.1.1 to 2008.12.31. Based on the dataset, we first apply the sampling techniques and dimension reduction method to preprocess the testing data. Then, we construct various kinds of classifiers (including basic classifiers, ensemble methods, and cost-sensitive methods) to predict the risk. The cost-sensitive method with random forest classifier is able to achieve recall (or sensitivity) as 100 %. At the recall of 100 %, the precision (positive predictive value, PPV), and specificity of cost-sensitive method with random forest classifier was 2.9 % and 14.87 %, respectively. In our study, we build a breast cancer risk assessment model by using the data mining techniques. Our model has the potential to be served as an assisting tool in the breast cancer screening.
authors.affiliation: Department of Computer Science and Information Engineering, Fu Jen Catholic University, New Tapei City, Taiwan, Republic of China, alien@csie.fju.edu.tw.
authors.forename: Jia-Lien
authors.initials: JL
authors.lastname: Hsu
authors.forename: Ping-Cheng
authors.initials: PC
authors.lastname: Hung
authors.forename: Hung-Yen
authors.initials: HY
authors.lastname: Lin
authors.forename: Chung-Ho
authors.initials: CH
authors.lastname: Hsieh
mesh_terms: D000367:Age Factors; D000368:Aged; D001499:Bayes Theorem; D001837:Body Weights and Measures; D001942:Breast Feeding; D001943:Breast Neoplasms / Q000453:epidemiology*; D003278:Contraceptives, Oral, Hormonal; D057225:Data Mining / Q000379:methods*; D055088:Early Detection of Cancer; D015914:Estrogen Replacement Therapy; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D060388:Support Vector Machine
chemical_list: D003278:Contraceptives, Oral, Hormonal