title: Effect of pantoprazole on insulin secretion in drug-naïve patients with type 2 diabetes.
abstract: To evaluate the effect of pantoprazole during 45 days on insulin secretion in drug-naïve patients with type 2 diabetes, a randomized, double blind, placebo control clinical trial was performed in 14 drug-naïve volunteers. Significant increases in late insulin phase and total insulin secretion, and decreases in HbA1c levels were found.
authors.affiliation: Institute of Experimental and Clinical Therapeutics, Physiology Department, Health Science University Center, University of Guadalajara, Guadalajara, Mexico; Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico. Electronic address: uiec@prodigy.net.mx.
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Ortiz
authors.affiliation: Institute of Experimental and Clinical Therapeutics, Physiology Department, Health Science University Center, University of Guadalajara, Guadalajara, Mexico.
authors.forename: Esperanza
authors.initials: E
authors.lastname: Martínez-Abundis
authors.affiliation: Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: Arieh R
authors.initials: AR
authors.lastname: Mercado-Sesma
authors.affiliation: Medical Research Unit in Clinical Epidemiology, Specialties Hospital, Medical Unit of High Specialty, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico.
authors.forename: Rebeca
authors.initials: R
authors.lastname: Álvarez-Carrillo
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000008:administration & dosage
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001786:Blood Glucose; D007328:Insulin; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole
keywords: Insulin secretion; NCT01541735, clinicaltrials.gov; Proton pump inhibitors; Type 2 diabetes