title: Helicobacter pylori infection and metabolic parameters: is there an association in elderly population?
abstract: BACKGROUND
  The association between Helicobacter pylori (HP), as one of the most prevalent infections, and serum glucose level was inconsistent with previous studies. Moreover, there are contradictory reports about the relationship between HP infection and lipid profile. The purpose of this study was to determine the relationship between HP infection with glycemic and lipid profiles in elderly people.
  
  
  METHODS
  This cross-sectional study was conducted on 1,300 subjects over 60 years in Amirkola Health and Ageing Project. After using a standard questionnaire, the venous sampling was done to determine FBS, triglyceride (TG), cholesterol, low density lipoprotein (LDL), high-density lipoprotein (HDL) and IgG anti-HP after a 12-h overnight fast. The information about the individuals was analyzed using SPSS-17. The P < 0.05 was considered statistically significant.
  
  
  RESULTS
  The prevalence of HP infection in diabetic and nondiabetic subjects was 77.5% and 75.7%, respectively, which had no statistically significant difference. Also, there was no significant difference between the serum lipid level including TG, LDL and HDL cholesterol with levels of anti-HP antibodies. The rate of HP infection in patients with hypertension was 75% and 78.3% in healthy patients, in which the difference was not statistically significant. In terms of body mass index (BMI), the prevalence of infection in the group with normal BMI was 77.3% and for the overweight and obese elderly population, it was 74.7%, and 77.5%, respectively (P = 0.445).
  
  
  CONCLUSIONS
  The findings revealed that in a large population of elderly in the northern part of Iran, HP infection is not associated with BMI, serum glucose and lipid profile as well as blood pressure.
authors.affiliation: Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Narges
authors.initials: N
authors.lastname: Sotuneh
authors.affiliation: Social Determinant of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ; Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Hosseini
authors.affiliation: Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Shokri-Shirvani
authors.affiliation: Social Determinant of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bijani
authors.affiliation: Social Determinant of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ; Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Ghadimi
keywords: Body mass index and hypertension; Helicobacter pylori; diabetes mellitus; glucose level; lipid profile; triglyceride and cholesterol