title: Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers.
abstract: OBJECTIVE
  To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.
  
  
  METHODS
  A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.
  
  
  RESULTS
  During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).
  
  
  CONCLUSIONS
  Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.
authors.affiliation: Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Hata
authors.affiliation: Biostatistics Center, Kurume University, Fukuoka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yonemoto
authors.affiliation: Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shikama
authors.affiliation: Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan; Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Tokushima, Japan.
authors.forename: Nanako
authors.initials: N
authors.lastname: Aki
authors.affiliation: Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Chisato
authors.initials: C
authors.lastname: Kosugi
authors.affiliation: Department of Nursing Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Tamura
authors.affiliation: Department of Nursing Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Ichihara
authors.affiliation: Department of Nursing Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Minagawa
authors.affiliation: Department of Nursing Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kuwamura
authors.affiliation: Clinical laboratory, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Miyoshi
authors.affiliation: Clinical laboratory, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakao
authors.affiliation: Clinical Research Center for Diabetes, Tokushima University Hospital, Tokushima, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Funaki
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D006801:Humans; D007564:Japan; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000208:ethnology / Q000517:prevention & control; D015999:Multivariate Analysis; D009784:Occupational Diseases / Q000097:blood* / Q000208:ethnology / Q000517:prevention & control; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D052242:Adiponectin; D015415:Biomarkers