title: Outcome of pigs with short gut syndrome submitted to orthotopic intestinal transplantation.
abstract: OBJECTIVE
  To evaluate the current model of small bowel resection and intestinal transplantation in pigs.
  
  
  METHODS
  Forty two Large White pigs were distributed in five groups: G1(n=6), G2(n=6) and G3(n=6) were submitted to 80%,100% and 100% plus right colon resection respectively and G4(n=7) and G5(n=5) to 100% SBR plus IT without and with immunosuppression based on Tacrolimus and Mycophenolic acid. Evaluation included weight control, clinical status, biochemical analysis and endoscopies for graft biopsies. Follow-up in G1 and 2 was 84 days, while in G3, four and five was ± three weeks.
  
  
  RESULTS
  G1 increased weight suggesting adaptation while G2 and 3 loused weight and inadequate adaptation. G4 and 5 died of acute cellular rejection (ACR) and sepses respectively. Overall survival in G1, 2, 3, 4 and 5 at 30 days was 100, 100, 0 and 20 %, respectively. Medium survival in G4 and 5 was 14 and 16 days.
  
  
  CONCLUSIONS
  The resection of 80% of small intestine in pigs is not suitable for short bowel syndrome induction. Intestinal transplantation with the proposed immunosuppression protocol was effective in prevent the occurrence of severe acute rejection, but inappropriate to increase recipients survival.
authors.affiliation: Department of Surgery and Orthopedics, Botucatu Medical School, State University of Sao Paulo, Brasil.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Llanos
authors.affiliation: Division of Transplantation, Department of Immunopathology, University of Miami School of Medicine, Miami, Florida, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Ruiz
authors.affiliation: Division of Transplantation, Department of Immunopathology, University of Miami School of Medicine, Miami, Florida, USA.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Division of Transplantation, Department of Immunopathology, University of Miami School of Medicine, Miami, Florida, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Delacruz
authors.affiliation: Department of Surgery and Orthopedics, Botucatu Medical School, State University of Sao Paulo, Brasil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bakonyi Neto
mesh_terms: D000818:Animals; D001706:Biopsy; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000473:pathology; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000097:blood / Q000627:therapeutic use; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D008297:Male; D023421:Models, Animal; D016377:Organ Transplantation / Q000379:methods; D011506:Proteins / Q000032:analysis; D015203:Reproducibility of Results; D012778:Short Bowel Syndrome / Q000209:etiology / Q000601:surgery*; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D007166:Immunosuppressive Agents; D011506:Proteins; D014280:Triglycerides; D002784:Cholesterol