title: Synthesis, characterization, crystal structure and cytotoxic properties of thiosemicarbazide Ni(II) and Zn(II) complexes.
abstract: Synthesis of new complexes of Ni(II) (1) and Zn(II) (2) with [1-(2-hydroxy-3,5-diiodobenzylidene)-4-phenylthiosemicarbazide] have been reported. The composition of these two complexes 1 and 2 is discussed on the basis of IR, (1)H NMR and UV spectral data along with their X-ray crystallographic data. The crystal structure of these two complexes has revealed that the free ligand (L) is deprotonated twice at the oxygen and sulfur atoms and they are coordinated with the complexes through phenoxide-O, azomethine-N and thiolate-S atoms. The single-crystal X-ray structures of complex (1) exhibits a square planar structure, while complex (2) reveals trigonal bipyramidal distorted square based pyramidal structure. Anticancer activity of ligand and the complexes 1-2 are evaluated in human adenocarcinoma (MCF-7) cells. The preliminary bioassay indicates that the free ligand and the complexes 1-2 exhibit inhibitory activity against the human adenocarcinoma cancer cell lines.
authors.affiliation: Department of Chemistry, K.S. Rangasamy College of Arts and Science (Autonomous), K.S. R. Kalvi Nagar, Tiruchengode 637215, India.
authors.forename: S
authors.initials: S
authors.lastname: Mathan Kumar
authors.affiliation: Department of Chemistry, Sethu Institute of Technology, Kariapatti 626 106, India.
authors.forename: J
authors.initials: J
authors.lastname: Rajesh
authors.affiliation: School of Physics, Madurai Kamaraj University, Madurai 625 021, India.
authors.forename: K
authors.initials: K
authors.lastname: Anitha
authors.affiliation: Department of Chemistry, M.S.S. Wakf Board College, Madurai 625 020, India.
authors.forename: K
authors.initials: K
authors.lastname: Dhahagani
authors.affiliation: PG & Research Department of Chemistry, Government Arts College(Men), Nandanam, Chennai 600035, India.
authors.forename: M
authors.initials: M
authors.lastname: Marappan
authors.affiliation: PG & Research Department of Chemistry, Presidency College (Autonomous), Chennai 600 005, India. Electronic address: jothivenkateswaran@yahoo.co.in.
authors.forename: N
authors.initials: N
authors.lastname: Indra Gandhi
authors.affiliation: PG and Research Department of Chemistry, Chikkanna Government Arts College, Tiruppur 641 602, India. Electronic address: rajagopal18@yahoo.com.
authors.forename: G
authors.initials: G
authors.lastname: Rajagopal
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D012663:Semicarbazides / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D012663:Semicarbazides; C005151:thiosemicarbazide; D009532:Nickel; D015032:Zinc
keywords: MCF-7; MTT assay; ONS donor ligand; Phenylthiosemicarbazone; X-ray