title: Cost-effectiveness study of pediatric atopic dermatitis in Asia: atopiclair vs. regular emollient (AD-ATOP).
abstract: BACKGROUND
  Atopic dermatitis (AD) is a highly prevalent, chronic relapsing condition in childhood with significant financial burden and impact on the quality of life of patients and caregivers. Proactive maintenance treatment with moisturizing agents is the mainstay AD therapy.
  
  
  OBJECTIVE
  The aim of this study was to assess the cost-effectiveness of a non-steroidal barrier cream (Atopiclair), compared to regular emollient in pediatric patients with mild-to-moderate AD.
  
  
  METHODS
  A Markov decision model was developed to evaluate the cost-effectiveness of Atopiclair versus regular emollient in 12 Asia-Pacific countries, grouped by income categories based on gross domestic product (GDP) per capita. Data was obtained from structured literature review, expert opinion, fee schedules, and findings from a 2012 survey of 12 Asia-Pacific countries. Analysis was performed a societal perspective.
  
  
  RESULTS
  In the base case analysis, Atopiclair was cost-effective against regular emollient, with USD786, USD499, and USD289 in cost savings per year for high, middle, and low-income countries, respectively. Sensitivity analyses showed that Atopiclair remained cost-effective versus regular emollient.
  
  
  CONCLUSIONS
  Modelling analysis showed that Atopiclair is a cost-effective treatment compared to regular emollient for mild-to-moderate pediatric AD in the countries included in the study.
authors.forename: Mark B Y
authors.initials: MB
authors.lastname: Tang
authors.forename: Kin Fon
authors.initials: KF
authors.lastname: Leong
authors.forename: Liang-Shiou
authors.initials: LS
authors.lastname: Ou
authors.forename: Zakiudin
authors.initials: Z
authors.lastname: Munasir
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Parekh
authors.forename: Soraya
authors.initials: S
authors.lastname: Azmi
authors.forename: Wilson H H
authors.initials: WH
authors.lastname: Low
authors.forename: Adrian
authors.initials: A
authors.lastname: Goh
mesh_terms: D001208:Asia; D002648:Child; D003362:Cost-Benefit Analysis; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000191:economics; D003879:Dermatologic Agents / Q000191:economics / Q000627:therapeutic use*; D004041:Dietary Fats / Q000191:economics / Q000627:therapeutic use*; D004643:Emollients / Q000191:economics / Q000627:therapeutic use*; D006034:Glycyrrhetinic Acid / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008390:Markov Chains; D010936:Plant Extracts / Q000191:economics / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D004041:Dietary Fats; D004643:Emollients; C530270:MAS063DP; D010936:Plant Extracts; D006034:Glycyrrhetinic Acid