title: Vitamin D deficiency in Parkinson's disease patients with orthostatic hypotension.
abstract: OBJECTIVE
  The purpose of our study was to investigate the associations between serum vitamin D3 levels and orthostatic hypotension (OH) in patients with Parkinson's disease (PD).
  
  
  METHODS
  Fifty-five patients with PD were enrolled in this study. Blood pressure (BP) measurements were gathered while the patients were in the supine position and while standing up. Then, the patients were divided into two groups: PD patients with and without OH. We compared the levels of serum 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 (calcitriol) between the two groups.
  
  
  RESULTS
  Serum 25-hydroxyvitamin D and calcitriol levels were significantly decreased in patients with OH compared with those without OH. The systolic and diastolic BPs and symptom severities significantly negatively correlated with the serum 25-hydroxyvitamin D and calcitriol levels.
  
  
  CONCLUSIONS
  Although the underlying mechanism for this association is not fully understood, our results suggest that low vitamin D status is associated with OH in patients with PD.
authors.affiliation: Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
authors.forename: W
authors.initials: W
authors.lastname: Jang
authors.affiliation: Department of Neurology, Haeundae Paik Hospital, Inje University, Busan, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Neurology, Soonchunhyang University College of Medicine, Seoul, Korea.
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Youn
authors.affiliation: Department of Neurology, Chungnam National University Hospital, College of Medicine, Daejeon, Korea.
authors.forename: E
authors.initials: E
authors.lastname: Oh
authors.affiliation: Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: K Y
authors.initials: KY
authors.lastname: Kwon
authors.affiliation: Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
authors.forename: K D
authors.initials: KD
authors.lastname: Jo
authors.affiliation: Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
authors.forename: M K
authors.initials: MK
authors.lastname: Lee
authors.affiliation: Department of Neurology, Hanyang University College of Medicine, Seoul, Korea.
authors.forename: H-T
authors.initials: HT
authors.lastname: Kim
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*
keywords: 25-hydroxyvitamin D; Parkinson's disease; calcitriol; orthostatic hypotension