title: Association between C reactive protein level and depressive symptoms in an elderly Korean population: Korean Social Life, Health and Aging Project.
abstract: OBJECTIVE
  The relationship between inflammatory markers and depressive symptoms has been reported inconsistently. Moreover, there were only a few studies conducted in an Asian population. The purpose of this study was to examine the association between C reactive protein (CRP) and depressive symptoms in an elderly Korean population.
  
  
  METHODS
  This study used data from the Korean Social Life, Health and Aging Project Health Examination Cohort, which started in 2011. Among participants aged 60 or over recruited from a rural community, 569 (224 men and 345 women) without a history of stroke, angina pectoris, myocardial infarction or CRP≥20 mg/L were employed for cross-sectional analyses. As a marker of systemic inflammation, CRP was measured. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression (CES-D) scale. Multiple linear regression analysis was used to investigate the relationship between CRP and depressive symptoms.
  
  
  RESULTS
  In men, CRP levels had significant associations with depressive symptoms before (β=0.420, p=0.010) and after (β=0.336, p=0.025) adjusting for age, body mass index, systolic blood pressure, number of comorbidities, smoking status, alcohol intake, marital status, education and sleep duration. However, in women, the association between CRP and depressive symptoms was not significant before (p=0.250) and after (p=0.256) adjustment.
  
  
  CONCLUSIONS
  Our findings suggest that elevated CRP levels are independently associated with the presence of depressive symptoms in elderly Korean men.
authors.affiliation: Department of Public Health, Yonsei University Graduate School, Seoul, Korea Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Bo Mi
authors.initials: BM
authors.lastname: Song
authors.affiliation: Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Ju-Mi
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Wungrak
authors.initials: W
authors.lastname: Choi
authors.affiliation: Department of Sociology, Yonsei University College of Social Sciences, Seoul, Korea.
authors.forename: Yoosik
authors.initials: Y
authors.lastname: Youm
authors.affiliation: Department of Clinical Nursing Science, Yonsei University College of Nursing, Seoul, Korea.
authors.forename: Sang Hui
authors.initials: SH
authors.lastname: Chu
authors.affiliation: Division of Silver Industry, Kangnam University, Yongin, Korea.
authors.forename: Yeong-Ran
authors.initials: YR
authors.lastname: Park
authors.affiliation: Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyeon Chang
authors.initials: HC
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism* / Q000523:psychology; D044466:Asian People; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006306:Health Surveys; D006801:Humans; D007249:Inflammation / Q000378:metabolism* / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D016017:Odds Ratio; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012424:Rural Population; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: GERIATRIC MEDICINE