title: Is infusion of subhypnotic propofol as effective as dexamethasone in prevention of postoperative nausea and vomiting related to laparoscopic cholecystectomy? A randomized controlled trial.
abstract: BACKGROUND
  Postoperative nausea and vomiting (PONV) is one of common complications in patients undergoing laparoscopic cholecystectomy (LC). Aim of this study was to compare the efficacy of subhypnotic (1 mg/kg/h) infusion of propofol with dexamethasone on PONV in patients undergoing LC.
  
  
  METHODS
  A total of 120 patients were included in this randomized, double-blind, placebo-controlled study. Patients were randomly assigned to 3 groups; patients of group dexamethasone (group D) were administrated 8 mg dexamethasone before induction of anesthesia, patients of group propofol (group P) were infused to subhypnotic (1 mg/kg/h) propofol during operation and patients of group control (group C) were applied infusion of 10% intralipid. The incidence of PONV and needs for rescue analgesic and antiemetic were recorded in the first 24 h postoperatively.
  
  
  RESULTS
  In the 0-24 h, the incidence of PONV was significantly lower in the group D and group P compared with the group C (37.5%, 40%, and 72.5%, resp.). There was no significant difference in the incidence of PONV and use of antiemetics and analgesic between group D and group P.
  
  
  CONCLUSIONS
  We concluded that infusion of propofol 1 mg/kg/h is as effective as dexamethasone for the prevention of PONV during the first 24 hours after anesthesia in patients undergoing LC.
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Ataturk University, Palandoken, 25140 Erzurum, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Celik
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Ataturk University, Palandoken, 25140 Erzurum, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Dostbil
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Ataturk University, Palandoken, 25140 Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Ataturk University, Palandoken, 25140 Erzurum, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ince
authors.affiliation: Department of Anesthesiology and Reanimation, Medical Faculty, Ataturk University, Palandoken, 25140 Erzurum, Turkey.
authors.forename: Ali
authors.identifier: 0000-0002-8467-8171
authors.initials: A
authors.lastname: Ahiskalioglu
authors.affiliation: Department of Anesthesiology and Reanimation, Erzurum Education Hospital, Palandoken, 25070 Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Comez
authors.affiliation: Department of Anesthesiology and Reanimation, Sakarya Education Hospital, Korucuk Mah., 54290 Adapazari, Turkey.
authors.forename: Ali Fuat
authors.initials: AF
authors.lastname: Erdem
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D003907:Dexamethasone / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D015994:Incidence; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D000932:Antiemetics; D006993:Hypnotics and Sedatives; D003907:Dexamethasone; D015742:Propofol