title: Antihyperlipidemic and biochemical activities of Mcy protein in streptozotocin induced diabetic rats.
abstract: BACKGROUND
  This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic "Mcy protein" isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model.
  
  
  METHODS
  Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests.
  
  
  RESULTS
  Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats.
  
  
  CONCLUSIONS
  Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, Tirupati, AP, India.
authors.forename: Saritha
authors.initials: S
authors.lastname: Marella
authors.forename: Dilip Rajasekhar
authors.initials: DR
authors.lastname: Maddirela
authors.forename: Kameswara Rao
authors.initials: KR
authors.lastname: Badri
authors.forename: Malaka Venkateshwarulu
authors.initials: MV
authors.lastname: Jyothi Kumar
authors.forename: Apparao
authors.initials: A
authors.lastname: Chippada
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005638:Fruit / Q000378:metabolism; D005951:Glucose Tolerance Test; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D029775:Momordica / Q000378:metabolism; D010940:Plant Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D013311:Streptozocin / Q000633:toxicity
chemical_list: D001786:Blood Glucose; D000960:Hypolipidemic Agents; D007328:Insulin; D008055:Lipids; D010940:Plant Proteins; D013311:Streptozocin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase