title: Rapid progression of primary sclerosing cholangitis complicated with ulcerative colitis.
abstract: Primary sclerosing cholangitis is a cholestatic condition with unknown etiology and long-standing, progressive course, leading to cirrhosis and requiring orthotropic liver transplant. In approximately 80%, primary sclerosing cholangitis is accompanied by inflammatory bowel disease, and in most cases the recognition of bowel disease precedes the diagnosis of primary sclerosing cholangitis. We describe a case of 22-year-old male diagnosed simultaneously with primary sclerosing cholangitis and ulcerative colitis, with a medical history suggesting uncommon prior development of the liver disease. Five months after the initial diagnosis, we observed advanced lesions of bile tree due to progression of primary sclerosing cholangitis, which led to the unusually fast necessity for the orthotopic liver transplant.
authors.affiliation: Department of Internal Medicine, Institute of Rural Health, 20-090 Lublin, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Pardak
authors.affiliation: Department of Internal Medicine, Institute of Rural Health, 20-090 Lublin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Walczak
authors.affiliation: Department of Clinical Endoscopy, Institute of Rural Health, 20-090 Lublin, Poland ; Department of Public Health and Social Medicine, University of Rzeszów, 35-959 Rzeszów, Poland.
authors.forename: Rafał S
authors.initials: RS
authors.lastname: Filip