title: The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain.
abstract: Interaction of Zn(2+) with the metal-binding domain of the English (H6R) amyloid-β mutant results in the formation of peptide dimers. The mutation causes the exclusion of His6 from the zinc chelation pattern observed in the intact domain and triggers the assembly of the dimers via zinc ions coordinated by (11)EVHH(14) fragments.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov street 32, 119991 Moscow, Russia. aamakarov@eimb.ru.
authors.forename: S A
authors.initials: SA
authors.lastname: Kozin
authors.forename: A A
authors.initials: AA
authors.lastname: Kulikova
authors.forename: A N
authors.initials: AN
authors.lastname: Istrate
authors.forename: P O
authors.initials: PO
authors.lastname: Tsvetkov
authors.forename: S S
authors.initials: SS
authors.lastname: Zhokhov
authors.forename: Y V
authors.initials: YV
authors.lastname: Mezentsev
authors.forename: O I
authors.initials: OI
authors.lastname: Kechko
authors.forename: A S
authors.initials: AS
authors.lastname: Ivanov
authors.forename: V I
authors.initials: VI
authors.lastname: Polshakov
authors.forename: A A
authors.initials: AA
authors.lastname: Makarov
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D002151:Calorimetry; D004739:England; D006801:Humans; D009154:Mutation / Q000235:genetics*; D011485:Protein Binding / Q000187:drug effects; D055503:Protein Multimerization / Q000187:drug effects*; D017434:Protein Structure, Tertiary; D066244:Proton Magnetic Resonance Spectroscopy; D020349:Surface Plasmon Resonance; D015032:Zinc / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D015032:Zinc