title: Cardiotrophin-1 is associated with increased risk of arterial stiffness.
abstract: OBJECTIVE
  Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV).
  
  
  METHODS
  We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s.
  
  
  RESULTS
  Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise.
  
  
  CONCLUSIONS
  Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.
authors.affiliation: Division of Endocrinology & Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Hao-Chang
authors.initials: HC
authors.lastname: Hung
authors.forename: Feng-Hwa
authors.initials: FH
authors.lastname: Lu
authors.forename: Horng-Yih
authors.initials: HY
authors.lastname: Ou
authors.forename: Hung-Tsung
authors.initials: HT
authors.lastname: Wu
authors.forename: Jin-Shang
authors.initials: JS
authors.lastname: Wu
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Yang
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D063177:Pulse Wave Analysis / Q000379:methods*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D059289:Vascular Stiffness
chemical_list: D016207:Cytokines; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; C092073:cardiotrophin 1
keywords: arterial stiffness; brachial-ankle pulse-wave velocity; cardiotrophin-1