title: Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders.
abstract: BACKGROUND
  The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMD(mdx) /J) mice on skeletal and cardiac muscle function have not been studied extensively.
  
  
  METHODS
  We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice.
  
  
  RESULTS
  We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers.
  
  
  CONCLUSIONS
  These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S794, INSERM, U974, CNRS UMR 7215, Institut de Myologie, Paris, France.|Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ferry
authors.affiliation: Université de Versailles Saint Quentin en Yvelines, Inflammation et thérapeutiques, Montigny-le-Bretonneux, France.
authors.forename: Rachid
authors.initials: R
authors.lastname: Benchaouir
authors.affiliation: Université Pierre et Marie Curie 6, Sorbonne Universités, UMR CNRS 8256, Biological Adaptation and Ageing, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Joanne
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S956, INSERM, ICAN Institute for Cardiometabolism and Nutrition, Paris, France.
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Peat
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, PECVM, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mougenot
authors.affiliation: Université Pierre et Marie Curie 6, Sorbonne Universités, UMR CNRS 8256, Biological Adaptation and Ageing, Paris, France.
authors.forename: Onnik
authors.initials: O
authors.lastname: Agbulut
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S794, INSERM, U974, CNRS UMR 7215, Institut de Myologie, Paris, France.
authors.forename: Gillian
authors.initials: G
authors.lastname: Butler-Browne
mesh_terms: D000367:Age Factors; D000818:Animals; D005260:Female; D006321:Heart / Q000502:physiology; D006614:Hindlimb / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D009043:Motor Activity / Q000502:physiology; D009119:Muscle Contraction / Q000502:physiology; D009206:Myocardium; D010805:Physical Conditioning, Animal / Q000379:methods* / Q000502:physiology*
keywords: cardiac muscle; function; mdx mouse; skeletal muscle; voluntary activity