title: Advances in skin regeneration: application of electrospun scaffolds.
abstract: The paucity of cellular and molecular signals essential for normal wound healing makes severe dermatological ulcers stubborn to heal. The novel strategies of skin regenerative treatments are focused on the development of biologically responsive scaffolds accompanied by cells and multiple biomolecules resembling structural and biochemical cues of the natural extracellular matrix (ECM). Electrospun nanofibrous scaffolds provide similar architecture to the ECM leading to enhancement of cell adhesion, proliferation, migration and neo tissue formation. This Review surveys the application of biocompatible natural, synthetic and composite polymers to fabricate electrospun scaffolds as skin substitutes and wound dressings. Furthermore, the application of biomolecules and therapeutic agents in the nanofibrous scaffolds viz growth factors, genes, antibiotics, silver nanoparticles, and natural medicines with the aim of ameliorating cellular behavior, wound healing, and skin regeneration are discussed.
authors.affiliation: Department of Nanotechnology and Tissue Engineering, Stem Cell Technology Research Center, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Norouzi
authors.affiliation: Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran.
authors.forename: Samaneh Moghadasi
authors.initials: SM
authors.lastname: Boroujeni
authors.affiliation: Department of Chemical Engineering, Tarbiat Modares University, Tehran, Iran.
authors.forename: Noushin
authors.initials: N
authors.lastname: Omidvarkordshouli
authors.affiliation: Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D049109:Cell Proliferation; D005109:Extracellular Matrix / Q000378:metabolism; D015316:Genetic Therapy / Q000379:methods; D029001:Herbal Medicine / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012038:Regeneration; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000378:metabolism*; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins; D011108:Polymers; D012834:Silver
keywords: bioactive agents; biocompatible polymers; electrospun scaffolds; skin tissue engineering; wound healing