title: Toward defining a 'lineage'--The case for dendritic cells.
abstract: The immune system consists of a heterogeneous ensemble of cell types that immunologists have tried to classify and order for decades. This classification has relied on varying criteria, resulting in major debates in the immunology community. Discovered in the late 1970s [1], dendritic cells (DCs) are no exception, and their membership to a distinct immune lineage is still vividly debated [2-6]. Here, we review recent work on the origin of DCs and discuss the possible definition of a separate 'DC lineage'.
authors.affiliation: Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands; Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. Electronic address: perie.leila@gmail.com.
authors.forename: Leïla
authors.initials: L
authors.lastname: Perié
authors.affiliation: Molecular Medicine Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. Electronic address: naik.s@wehi.edu.au.
authors.forename: Shalin H
authors.initials: SH
authors.lastname: Naik
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*; D051941:fms-Like Tyrosine Kinase 3 / Q000276:immunology / Q000378:metabolism
chemical_list: C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3
keywords: Cellular barcoding; Dendritic cells; Immune cell types; Lineage; Lineage tracing; Mouse