title: Association of PELI1 polymorphisms in systemic lupus erythematosus susceptibility in a Chinese population.
abstract: OBJECTIVE
  Studies in animal models have indicated that Pellino 1 is involved in inflammatory and autoimmune diseases, such as systemic lupus erythematosus (SLE). The current study was designed to determine whether PELI1 confers genetic susceptibility to SLE in humans, as assessed in a Chinese Han population.
  
  
  METHODS
  Blood samples were drawn from patients diagnosed with SLE and healthy volunteers. Three single nucleotide polymorphism (SNP) loci with a minor allele frequency of at least 0.05 were chosen to evaluate the correlation between PELI1 genotype and the incidence of SLE.
  
  
  RESULTS
  There was a significant difference in the frequency distribution of the rs329497 allele between the SLE patients and the healthy controls (A vs. G; Bonferroni corrected p = 0.036, odds ratio = 0.75, 95% confidence interval = 0.60-0.94). No differences in the genotype and allele frequencies of other SNP loci were observed between the two groups. Furthermore, the alleles and genotypes of the three SNPs were not associated with lupus nephritis.
  
  
  CONCLUSIONS
  In the Chinese Han population, PELI1 SNPs may be associated with SLE susceptibility.
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: F-R
authors.initials: FR
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Z-F
authors.initials: ZF
authors.lastname: Zhai
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: X-W
authors.initials: XW
authors.lastname: Shi
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: L
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: B-Y
authors.initials: BY
authors.lastname: Zhong
authors.affiliation: Department of Dermatology, Affiliated Hospital of Guilin Medical College, Guilin, China.
authors.forename: W-J
authors.initials: WJ
authors.lastname: Yan
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: You
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: N
authors.initials: N
authors.lastname: Luo
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: D-M
authors.initials: DM
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China haofei62@medmail.com.cn.
authors.forename: F
authors.initials: F
authors.lastname: Hao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D009687:Nuclear Proteins; C485959:PELI1 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Haplotype; PELI1; Pellino 1; single nucleotide polymorphism; systemic lupus erythematosus