title: Effect of selective blockade of α₂-adrenoceptor subtypes on cardiovascular system in rats.
abstract: Selective blockade of various α2-adrenoceptors exerts various effects on the cardiovascular system in rats. Blockade of α2A/D-adrenoceptors in experimental animals decelerates and then accelerates HR. Blockade of α2B-adrenoceptors produces a negative chronotropic effect; blockade of α2C-adrenoceptors has a positive chronotropic effect. Administration of selective blockers of α2A/D- and α2B-adrenoceptors causes hypotension, while selective blockade of α2C-adrenoceptors increases BP.
authors.affiliation: Department of Anatomy, Physiology and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, zefirovtl@mail.ru.
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.forename: L I
authors.initials: LI
authors.lastname: Khisamieva
authors.forename: N I
authors.initials: NI
authors.lastname: Ziyatdinova
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D058669:Adrenergic alpha-2 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D051381:Rats
chemical_list: D058669:Adrenergic alpha-2 Receptor Antagonists