title: Neovascular age-related macular degeneration associated with no light perception.
abstract: OBJECTIVE
  To study eyes with no light perception (NLP) occurring secondary to neovascular age-related macular degeneration (AMD).
  
  
  METHODS
  Records of consecutive patients with neovascular AMD seen during a 10-year period were reviewed to ascertain which patients had NLP due to neovascular AMD.
  
  
  RESULTS
  Ten of 1,150 patients (0.9%) with neovascular AMD had NLP in one eye (study eye) from neovascular AMD. All 10 patients had bilateral neovascular AMD. Each study eye had a large macular disciform scar and 360° peripapillary subretinal fibrovascular tissue. Seven of nine (78%) study eyes had optic disc pallor, versus none of eight fellow eyes (P = .04). Mean fellow eye vision was 20/231, ranging from 20/50 to NLP (P = .006 vs study eyes). No seeing fellow eye had choroidal neovascularization encircling the optic disc (P = .0004).
  
  
  CONCLUSIONS
  NLP from neovascular AMD is associated with 360° peripapillary subretinal fibrosis. This fibrosis may cause chronic ischemic optic neuropathy contributing to extinguished vision.
authors.forename: Gary C
authors.initials: GC
authors.lastname: Brown
authors.forename: Mahdi M
authors.initials: MM
authors.lastname: Basha
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Brown
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001766:Blindness / Q000175:diagnosis / Q000209:etiology*; D020256:Choroidal Neovascularization / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005355:Fibrosis; D006801:Humans; D012160:Retina / Q000473:pathology*; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology; D014792:Visual Acuity; D057135:Wet Macular Degeneration / Q000150:complications* / Q000175:diagnosis