title: Surfactant with and without bronchoalveolar lavage in an experimental model of meconium aspiration syndrome.
abstract: OBJECTIVE
  To assess the effect of surfactant administration, preceded or not by bronchoalveolar lavage (BAL) with dilute surfactant, on pulmonary function in experimental severe meconium aspiration syndrome.
  
  
  METHODS
  Twenty-one newborn pigs received 20% meconium in saline intratracheally and were randomly allocated to one of three groups: I, control; II, surfactant only (poractant alfa, 200 mg/kg); or III, dilute surfactant BAL followed by 125 mg/kg surfactant. Arterial blood gases (ABGs), lung compliance, and resistance were assessed.
  
  
  RESULTS
  Thirty minutes after treatment, mean PaO2 (mm Hg) increased to 72 in group I, to 106 in group II and to 172 in group III (P=0.01). After 3 h, mean PaO2 (mm Hg) was 70 in group I, 95 in group II and 198 in group III (P<0.01). After 6 h, it was 79 in group I, 110 in group II, and 217 in group III (P=0.01). From the 30-min point onward, there were significant differences among treatment groups in all other parameters and at every point of assessment, except for compliance and resistance 3 h after treatment.
  
  
  CONCLUSIONS
  BAL with dilute surfactant, followed by an additional dose of surfactant, produced significant improvements in ABGs and pulmonary mechanics as compared with a single dose of surfactant.
authors.forename: Roseli
authors.initials: R
authors.lastname: Henn
authors.forename: Renato Machado
authors.initials: RM
authors.lastname: Fiori
authors.forename: Humberto Holmer
authors.initials: HH
authors.lastname: Fiori
authors.forename: Manuel Ruttkay
authors.initials: MR
authors.lastname: Pereira
authors.forename: Maurício Obal
authors.initials: MO
authors.lastname: Colvero
authors.forename: Pedro Celiny
authors.initials: PC
authors.lastname: Ramos Garcia
authors.forename: Priscila
authors.initials: P
authors.lastname: Padoim
authors.forename: Jaqueline Basso
authors.initials: JB
authors.lastname: Stivanin
mesh_terms: D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D018893:Bronchoalveolar Lavage; D003131:Combined Modality Therapy; D008471:Meconium Aspiration Syndrome / Q000628:therapy*; D010743:Phospholipids / Q000627:therapeutic use*; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D011897:Random Allocation; D013552:Swine; D016896:Treatment Outcome
chemical_list: D001688:Biological Products; D010743:Phospholipids; D011663:Pulmonary Surfactants; C068291:poractant alfa