title: Cell Permeable Au@ZnMoS4Core-Shell Nanoparticles: Towards a Novel Cellular Copper Detoxifying Drug for Wilson's Disease.
abstract: A layer-by-layer self-assembly method leads to the formation of Au@ZnMoS4core-shell nanoparticles (NPs). The PEGylated Au@ZnMoS4NPs are highly water-dispersible, exhibit no cytotoxicity and can penetrate the cell membrane to selectively remove copper(I) ions from HepG2 cells in the presence of other endogenous and biologically essential metal ions including Mg(II), Ca(II), Mn(II) and Fe(II), demonstrating their potential as a novel intracellular copper detoxifying agent.
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240.
authors.forename: Vindya S
authors.initials: VS
authors.lastname: Perera
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240.
authors.forename: Haijian
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.affiliation: Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44240.
authors.forename: Songping D
authors.initials: SD
authors.lastname: Huang
keywords: Biomedical Applications; Core/Shell Nanoparticles; Drug Delivery; Functional Coatings; Gold Nanoparticles; Layer-by-Layer Self-Assembly