title: Dentoalveolar trauma and minor trauma as precipitating factors for medication-related osteonecrosis of the jaw (ONJ): a retrospective study of 149 consecutive patients from the Copenhagen ONJ Cohort.
abstract: OBJECTIVE
  Medication-related osteonecrosis of the jaw (ONJ) is often preceded by dentoalveolar trauma. The aim of this study was to examine the frequency of dentoalveolar trauma precipitated ONJ and compare trauma-precipitated ONJ with spontaneously developing ONJ.
  
  
  METHODS
  This was a retrospective study. All patients were examined according to a standard ONJ chart.
  
  
  RESULTS
  Among 149 consecutive ONJ patients from the Copenhagen Cohort, 95 (64%) had a dentoalveolar trauma before referral (trauma group): dental extractions (n = 80); denture-related sore mouth (n = 12); and others (n = 3). The remaining 54 patients had spontaneous ONJ (spontaneous group). The mean time from oral trauma to referral for ONJ was 8 months.
  
  
  CONCLUSIONS
  This study documented that dentoalveolar trauma precipitated ONJ in the majority of cases. However, even minor trauma, such as intubation and impression tray lesions, precipitated ONJ in a few cases (1%). Besides the occurrence of fistula to the skin and a difference in the male-to-female ratio, we found no significant difference between the spontaneous and trauma groups.
authors.affiliation: Resident in Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen University Hospital, Department of Oral and Maxillofacial Surgery, Copenhagen, Denmark. Electronic address: Pouyayazdi@yahoo.dk.
authors.forename: Pouya Masroori
authors.initials: PM
authors.lastname: Yazdi
authors.affiliation: Senior Consultant Oral and Maxillofacial Surgeon, Rigshospitalet, Copenhagen University Hospital, Department of Oral and Maxillofacial Surgery, Copenhagen, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Schiodt
mesh_terms: D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology*; D004164:Diphosphonates / Q000627:therapeutic use; D005151:Facial Injuries / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D004164:Diphosphonates