title: Regional homogeneity of resting-state brain abnormalities in violent juvenile offenders: a biomarker of brain immaturity?
abstract: The authors investigated whether male violent juvenile offenders demonstrate any differences in local functional connectivity indicative of delayed maturation of the brain that may serve as a biomarker of violence. Twenty-nine violent juvenile offenders and 28 age-matched controls were recruited. Regional homogeneity (ReHo) method was used to analyze resting-state magnetic resonance images. Violent offenders showed significantly lower ReHo values in the right caudate, right medial prefrontal cortex, and left precuneus, and higher values in the right supramarginal gyrus than the controls. These regions had both high sensitivity and specificity in distinguishing between the two groups suggesting that dysfunction in these regions can be used to correctly classify those individuals who are violent. Dysfunction in the right medial prefrontal-caudate circuit may, therefore, represent an important biomarker of violence juvenile males.
authors.affiliation: From the Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, Hunan, China (CC, YZ, CL, JZ, WX, LL); Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, P.R.China (CC); the Hunan Province Technology Institute of Psychiatry, China (CC, YZ, CL, JZ, WX, LL); the Key Laboratory of Psychiatry and Mental Health of Hunan Province, Hunan, China (CC, YZ, CL, JZ, WX, LL); the Dept. of Radiology, Beijing Anding Hospital, Capital Medical University, Beijing, China (CHL, BJ); the School of Biomedical Engineering, Capital Medical University, Beijing, China (CHL, BJ); and the University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford, United Kingdom (KW).
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Jiansong
authors.initials: J
authors.lastname: Zhou
authors.forename: Chunhong
authors.initials: C
authors.lastname: Liu
authors.forename: Katrina
authors.initials: K
authors.lastname: Witt
authors.forename: Yingdong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Jing
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Wang
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
mesh_terms: D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007604:Juvenile Delinquency; D008279:Magnetic Resonance Imaging; D008297:Male; D012372:ROC Curve; D012146:Rest; D014754:Violence