title: Light sensitization of DNA nanostructures via incorporation of photo-cleavable spacers.
abstract: Using light irradiation as a trigger, large-scale structural reconfiguration of DNA nanostructures is demonstrated. We incorporated photo-cleavable spacers at strategic locations within the short oligonucleotide strands connecting adjacent helices within a DNA origami sphere, and then used light to transform the sphere into two tethered hemispheres.
authors.affiliation: Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA. xuehan@bu.edu.
authors.forename: Richie E
authors.initials: RE
authors.lastname: Kohman
authors.forename: Xue
authors.initials: X
authors.lastname: Han
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D008027:Light; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects*; D010782:Photolysis
chemical_list: D004247:DNA