title: P388 leukemia in CDF₁ mice as the test system for studies of tumor-associated neoangiogenesis and hypercoagulation.
abstract: Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia.
authors.affiliation: St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russia, alexandr.trashkov@gmail.com.
authors.forename: A P
authors.initials: AP
authors.lastname: Trashkov
authors.forename: A V
authors.initials: AV
authors.lastname: Panchenko
authors.forename: E S
authors.initials: ES
authors.lastname: Kayukova
authors.forename: R V
authors.initials: RV
authors.lastname: Korablev
authors.forename: V A
authors.initials: VA
authors.lastname: Pechatnikova
authors.forename: A G
authors.initials: AG
authors.lastname: Vasil'ev
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D007941:Leukemia P388 / Q000503:physiopathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000097:blood / Q000503:physiopathology*; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D018709:Statistics, Nonparametric; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A