title: A new biomimetic route to engineer enzymatically active mechano-responsive materials.
abstract: Using modified β-galactosidase covalently linked to cross-linked polyelectrolyte multilayers (PEM), catalytically active materials have been designed. Their enzymatic activity can be modulated, partially in a reversible way, simply by stretching. This strategy, based on enzyme conformational changes, constitutes a new tool for the development of biocatalytic mechano-responsive materials.
authors.affiliation: ICS (UPR22-CNRS), 23 rue du Loess, 67034, Strasbourg, France. schaaf@unistra.fr.
authors.forename: César
authors.initials: C
authors.lastname: Rios
authors.forename: Johan
authors.initials: J
authors.lastname: Longo
authors.forename: Sarah
authors.initials: S
authors.lastname: Zahouani
authors.forename: Tony
authors.initials: T
authors.lastname: Garnier
authors.forename: Cédric
authors.initials: C
authors.lastname: Vogt
authors.forename: Andreas
authors.initials: A
authors.lastname: Reisch
authors.forename: Bernard
authors.initials: B
authors.lastname: Senger
authors.forename: Fouzia
authors.initials: F
authors.lastname: Boulmedais
authors.forename: Joseph
authors.initials: J
authors.lastname: Hemmerlé
authors.forename: Karim
authors.initials: K
authors.lastname: Benmlih
authors.forename: Benoît
authors.initials: B
authors.lastname: Frisch
authors.forename: Pierre
authors.initials: P
authors.lastname: Schaaf
authors.forename: Loïc
authors.initials: L
authors.lastname: Jierry
authors.forename: Philippe
authors.initials: P
authors.lastname: Lavalle
mesh_terms: D055162:Biocatalysis; D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D032701:Biomimetics; D001709:Biotechnology / Q000379:methods*; D004573:Electrolytes / Q000737:chemistry / Q000378:metabolism; D004789:Enzyme Activation; D008958:Models, Molecular; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D001616:beta-Galactosidase / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004573:Electrolytes; D011108:Polymers; D001616:beta-Galactosidase