title: Spectral-domain optical coherence tomography measurements of choroidal thickness and outer retinal disruption in macular telangiectasia type 2.
abstract: OBJECTIVE
  To evaluate subfoveal choroidal thickness (CT) and the extent of outer retinal disruption in patients with macular telangiectasia type 2 (MacTel2) compared with healthy eyes.
  
  
  METHODS
  In this prospective, observational, cohort study, 62 patients (62 eyes) with Mac-Tel2 and 130 healthy controls (130 eyes) underwent a complete ophthalmological examination, spectral-domain optical coherence tomography (SD-OCT) imaging, and axial length measurements. Patients in the study group also underwent color fundus photography, fundus autofluorescence, and fluorescein angiography. En face SD-OCT imaging was used to assess abnormalities involving the photoreceptor inner segment/outer segment/ellipsoid zone (IS/OS/EZ).
  
  
  RESULTS
  After adjusting for age and axial length, the authors found that eyes with MacTel2 had a mean CT measurement that was greater than control eyes (P = .007). There was a negative correlation between the visual acuity and the area of IS/OS/EZ damage (P = .009), but no statistically significant correlation was seen between CT and the area of IS/OS/EZ damage.
  
  
  CONCLUSIONS
  Eyes with MacTel2 were found to have thicker CT measurements than control eyes. While the extent of IS/OS/EZ disruption correlated with the loss of visual acuity, this damage did not correlate with CT measurements.
authors.forename: Renata Portella
authors.initials: RP
authors.lastname: Nunes
authors.forename: Raquel
authors.initials: R
authors.lastname: Goldhardt
authors.forename: Carlos Alexandre
authors.initials: CA
authors.lastname: de Amorim Garcia Filho
authors.forename: Mariana R
authors.initials: MR
authors.lastname: Thorell
authors.forename: Ashkan M
authors.initials: AM
authors.lastname: Abbey
authors.forename: Ajay E
authors.initials: AE
authors.lastname: Kuriyan
authors.forename: Yasha S
authors.initials: YS
authors.lastname: Modi
authors.forename: Milan
authors.initials: M
authors.lastname: Shah
authors.forename: Zohar
authors.initials: Z
authors.lastname: Yehoshua
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.forename: William
authors.initials: W
authors.lastname: Feuer
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058452:Axial Length, Eye / Q000473:pathology; D002829:Choroid / Q000473:pathology*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology*; D011446:Prospective Studies; D058456:Retinal Telangiectasis / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D055815:Young Adult