title: Making the LINC: SUN and KASH protein interactions.
abstract: Cell nuclei are physically integrated with the cytoskeleton through the linker of nucleoskeleton and cytoskeleton (LINC) complex, a structure that spans the nuclear envelope to link the nucleoskeleton and cytoskeleton. Outer nuclear membrane KASH domain proteins and inner nuclear membrane SUN domain proteins interact to form the core of the LINC complex. In this review, we provide a comprehensive analysis of the reported protein-protein interactions for KASH and SUN domain proteins. This critical structure, directly connecting the genome with the rest of the cell, contributes to a myriad of cellular functions and, when perturbed, is associated with human disease.
authors.forename: Dae In
authors.initials: DI
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Birendra
authors.forename: Kyle J
authors.initials: KJ
authors.lastname: Roux
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015530:Nuclear Matrix / Q000737:chemistry / Q000378:metabolism*; D009687:Nuclear Proteins / Q000032:analysis / Q000378:metabolism*; D060066:Protein Interaction Maps
chemical_list: D009687:Nuclear Proteins