title: Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application.
abstract: Magnesium (Mg) alloys have revolutionized the application of temporary load-bearing implants as they meet both engineering and medical requirements. However, rapid degradation of Mg alloys under physiological conditions remains the major obstacle hindering the wider use of Mg-based implants. Here we developed a simple method of preparing a nanoscale MgF2 film on Mg-Nd-Zn-Zr (denoted as JDBM) alloy, aiming to reduce the corrosion rate as well as improve the biological response. The corrosion rate of JDBM alloy exposed to artificial plasma is reduced by ∼20% from 0.337 ± 0.021 to 0.269 ± 0.043 mm·y(-1) due to the protective effect of the MgF2 film with a uniform and dense physical structure. The in vitro cytocompatibility test of MgF2-coated JDBM using human umbilical vein endothelial cells indicates enhanced viability, growth, and proliferation as compared to the naked substrate, and the MgF2 film with a nanoscale flakelike feature of ∼200-300 nm presents a much more favorable environment for endothelial cell adhesion, proliferation, and alignment. Furthermore, the animal experiment via implantation of MgF2-coated JDBM stent to rabbit abdominal aorta confirms excellent tissue compatibility of the well re-endothelialized stent with no sign of thrombogenesis and restenosis in the stented vessel.
authors.affiliation: National Engineering Research Center of Light Alloys Net Forming and State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University , Shanghai 200240, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Mao
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.forename: Jiahui
authors.initials: J
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Minsuk
authors.initials: M
authors.lastname: Kwak
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Xue
authors.forename: Jia
authors.initials: J
authors.lastname: Pei
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.forename: Rong
authors.initials: R
authors.lastname: Fan
authors.forename: Junbo
authors.initials: J
authors.lastname: Ge
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Ding
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055664:Electrochemical Techniques; D005459:Fluorides / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D017616:Magnesium Compounds / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D019736:Prostheses and Implants; D011817:Rabbits; D015607:Stents; D013499:Surface Properties; D014463:Ultrasonography
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D017616:Magnesium Compounds; C571250:Mg-Nd-Zn-Zr alloy; C031288:magnesium fluoride; D005459:Fluorides
keywords: cytocompatibility; endothelialization; in vitro degradation; magnesium alloy; surface modification