title: Hypoxia-shaped vascular niche for cancer stem cells.
abstract: The tumour microenvironment, long considered as determining cancer development, still offers research fields to define hallmarks of cancer. An early key-step, the "angiogenic switch", allows tumour growth. Pathologic angiogenesis is a cancer hallmark as it features results of tumour-specific properties that can be summarised as a response to hypoxia. The hypoxic state occurs when the tumour mass reaches a volume sufficient not to permit oxygen diffusion inside the tumour centre. Thus tumour cells turn on adaptation mechanisms to the low pO2 level, inducing biochemical responses in terms of cytokines/chemokines/receptors and consequently recruitment of specific cell types, as well as cell-selection inside the tumour. Moreover, these changes are orchestrated by the microRNA balance strongly reflecting the hypoxic milieu and mediating the cross-talk between endothelial and tumour cells. MicroRNAs control of the endothelial precursor-vascular settings shapes the niche for selection of cancer stem cells.
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France ; Skaggs School of Pharmacy and Pharmaceutical Sciences and KACST UCSD Center of Excellence in Nanomedicine, University of California, San Diego, La Jolla, California, United States.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Collet
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France.
authors.forename: Bouchra
authors.initials: B
authors.lastname: El Hafny-Rahbi
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Nadim
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France ; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Tejchman
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France ; Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Klimkiewicz
authors.affiliation: Centre for Molecular Biophysics, Cell Recognition and Glycobiology, UPR4301-CNRS, Orléans, France.
authors.forename: Claudine
authors.initials: C
authors.lastname: Kieda
keywords: angiogenesis; cancer stem cell; endothelial precursor cell; hypoxia; microRNA