title: Pharmacokinetics of cefquinome in tilapia (Oreochromis niloticus) after a single intramuscular or intraperitoneal administration.
abstract: The pharmacokinetics of cefquinome was studied in plasma after a single dose (10 mg/kg) of intramuscular (i.m.) or intraperitoneal (i.p.) administration to tilapia (Oreochromis niloticus) in freshwater at 30 °C. Ten fish per sampling point were examined after treatment. The data were fitted to two-compartment open models following both routes of administration. The estimates of total body clearance (CL/F), volume of distribution (Vd/F), and absorption half-life (T1/2ka ) were 0.049 and 0.037 L/h/kg, 0.41 and 0.33 L/kg, and 0.028 and 0.035 h following i.m. and i.p. administration, respectively. After i.m. injection, the elimination half-life (T1⁄2β ) was calculated to be 5.81 h, the maximum plasma concentration (Cmax ) to be 49.40 μg/mL, the time to peak plasma cefquinome concentration (Tmax ) to be 0.14 h, and the area under the plasma concentration-time curve (AUC) to be 204.6 μg h/mL. Following i.p. administration, the corresponding estimates were 6.05 h, 44.39 μg/mL, 0.17 h and 267.8 μg h/mL. The minimum inhibitory concentrations of cefquinome, determined for 30 strains of Streptococcus agalactiae isolated from diseased tilapia, ranged from 0.015 to 0.12 μg/mL. Results from these studies support that 10 mg cefquinome/kg body weight daily could be expected to control tilapia bacterial pathogens inhibited in vitro by a minimal inhibitory concentration value of ≤2 μg/mL.
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: L
authors.initials: L
authors.lastname: Ma
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture and Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
authors.forename: G
authors.initials: G
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D007273:Injections, Intramuscular / Q000662:veterinary; D007274:Injections, Intraperitoneal / Q000662:veterinary; D017210:Tilapia / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; C068212:cefquinome