title: [A tamponade complicating an acute eosinophilic pericarditis due to a myeloproliferative/myelodysplastic syndrome].
abstract: Cardiac involvement in eosinophilia is potentially fatal and requires early diagnosis and prompt treatment. We report here the case of a 71-year-old female patient with eosinophilia>10,000/mm(3) for 2 months due to a myeloproliferative/myelodysplastic syndrome, with a rapidly progressive exertional dyspnea explained by an important circumferential eosinophilic pericarditis. Due to a rapid evolution to a tamponade, an emergent surgical drainage was performed. Subsequent medical treatment combined high-dose corticosteroids (1mg/kg/day) with hydroxyurea and imatinib. The outcome was favourable with regression of the effusion, of the volume overload symptoms and decrease in eosinophilia.
authors.affiliation: Département de médecine interne 1 et pneumologie, CHRU de Brest, boulevard Tanguy-Prigent, 29609 Brest cedex, France. Electronic address: claire.demoreuil@chu-brest.fr.
authors.forename: C
authors.initials: C
authors.lastname: de Moreuil
authors.affiliation: Centre de diagnostic et de thérapeutique, hôpital hôtel-Dieu, université Paris Descartes, 1, place du Parvis-Notre-Dame, 75004 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Lieber
authors.affiliation: Département d'hématologie, hôpital Saint-Antoine, université Pierre et Marie Curie, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Marjanovic
authors.affiliation: Service de chirurgie thoracique, hôpital Cochin, université Paris Descartes, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Bobbio
authors.affiliation: Inserm CIC 0502, CHRU de Brest, boulevard Tanguy-Prigent, 29609 Brest cedex, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Alavi
authors.affiliation: Centre de diagnostic et de thérapeutique, hôpital hôtel-Dieu, université Paris Descartes, 1, place du Parvis-Notre-Dame, 75004 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Blacher
authors.affiliation: Département d'hématologie, hôpital Saint-Antoine, université Pierre et Marie Curie, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Marie
mesh_terms: D000368:Aged; D002305:Cardiac Tamponade / Q000209:etiology*; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006801:Humans; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000150:complications*; D010493:Pericarditis / Q000209:etiology*
keywords: Eosinophilia; Hyperéosinophilie; Imatinib; Myeloproliferative/myelodysplastic syndrome; Pericarditis; Péricardite; Syndrome myéloprolifératif/myélodysplasique; Tamponade; Tamponnade