title: [High sensitivity C protein as an independent risk factor in people with and without history of cardiovascular disease].
abstract: Among the new cardiovascular event (CVE) risk biomarkers, C-reactive protein detected using high sensitive techniques (hs-CRP) has been one of the most commonly evaluated. In this review, the available evidence on the usefulness of hs-CRP was explored as an independent risk event factor in subjects with no cardiovascular history and as prognosis in case of chronic or acute cardiovascular condition. An overview (revision of revisions) was carried out searching in the main bibliographic databases and in other general Internet search engines. During the first stage, systematic reviews, clinical practice guidelines, health technology assessments and coverage policies were found and, during the second stage primary studies published after the systematic review search dates were added. Seven hundred and seventy four quotes were found, including 36 papers assessing the role of hs-CRP in healthy populations or with cardiovascular history. High quality evidence was found pointing out hs-CRP, both as risk factor in the general population and as prognostic factor in those with CVE, in all the populations assessed. It was most useful in subjects with a history of CVE and intermediate risk of events at 10 years; where adding hs-CRP to the classical models for event risk estimation improves risk staging. There was no consensus on its clinical usefulness as a prognostic marker in subjects with chronic or acute disease.
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina. Electronic address: vbrito@iecs.org.ar.
authors.forename: Viviana
authors.initials: V
authors.lastname: Brito
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Andrea
authors.initials: A
authors.lastname: Alcaraz
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Federico
authors.initials: F
authors.lastname: Augustovski
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Andrés
authors.initials: A
authors.lastname: Pichón-Riviere
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Sebastián
authors.initials: S
authors.lastname: García-Martí
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Ariel
authors.initials: A
authors.lastname: Bardach
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Agustín
authors.initials: A
authors.lastname: Ciapponi
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Analía
authors.initials: A
authors.lastname: Lopez
authors.affiliation: Departamento de Evaluaciones de Tecnologías Sanitarias y Economía de la Salud, Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina.
authors.forename: Daniel
authors.initials: D
authors.lastname: Comandé
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood*; D006801:Humans; D011486:Protein C / Q000032:analysis*; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D011486:Protein C
keywords: Angina inestable; Argentina; Cardiovascular risk factors; Enfermedad coronaria estable; Factores de riesgo cardiovascular; Infarto de miocardio; Myocardial infarction; Proteína C reactiva ultrasensible; Stable coronary disease; Ultrasensitive C-reactive protein; Unstable angina