title: Impact of increased admission lipid levels on periprocedural myocardial injury following an elective percutaneous coronary intervention.
abstract: OBJECTIVE
  Periprocedural myocardial injury (PMI) is known to be a predictor of in-hospital cardiac events and long-term adverse outcomes following a percutaneous coronary intervention (PCI). We aimed to evaluate the correlation between preprocedural serum lipid levels and PMI in patients undergoing elective PCI.
  
  
  METHODS
  The final study group included 195 patients (60.1±0.7 years old, 68 women and 127 men). Serum high-sensitive troponin T (hscTnT) concentrations were measured immediately before PCI and 12 h after PCI. Serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglyceride (TG) levels were determined immediately before PCI. Serum hscTnT concentrations were adjusted for the clinical and procedural characteristics of the patients using the weighted least-square regression analysis.
  
  
  RESULTS
  The average preprocedural hscTnT concentration was 8.1±0.2 ng/l. The average serum hscTnT concentration increased to 34.1±2.8 ng/l (P<0.001) 12 h after PCI. Postprocedural hscTnT concentrations were correlated positively to serum concentrations of TC (r=0.435; P<0.001), LDL-C (r=0.349; P<0.001), and TG (r=0.517; P<0.001). There was also a positive correlation (r=0.205; P<0.01) between postprocedural hscTnT and lesion length. Mild-moderate PMI (postprocedural hscTnT≥14 to <70 ng/l) and severe PMI (postprocedural hscTnT≥70 ng/l) were observed in 122 (48.7%) and 27 (13.9%) patients, respectively. The patients with severe PMI had higher serum TC (P<0.001), LDL-C (P<0.001), and TG (P<0.001) concentrations.
  
  
  CONCLUSIONS
  The present study indicates that increased preprocedural TC, LDL-C, and TG serum levels are associated with PMI and its severity following elective PCI.
authors.affiliation: Departments of aCardiology bMedical Biochemistry, Acibadem University Faculty of Medicine cCardiology Department, Mehmet Akif Ersoy Cardiovascular Surgery Training and Research Center, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Buturak
authors.forename: Aleks
authors.initials: A
authors.lastname: Degirmencioglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erturk
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Karakurt
authors.forename: Ali Rza
authors.initials: AR
authors.lastname: Demir
authors.forename: Ozgur
authors.initials: O
authors.lastname: Surgit
authors.forename: Hamdi
authors.initials: H
authors.lastname: Pusuroglu
authors.forename: Ozgur
authors.initials: O
authors.lastname: Akgul
authors.forename: Mustafa
authors.initials: M
authors.lastname: Serteser
authors.forename: Tugrul
authors.initials: T
authors.lastname: Norgaz
authors.forename: Sevket
authors.initials: S
authors.lastname: Gorgulu
mesh_terms: D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000601:surgery; D062645:Percutaneous Coronary Intervention; D057234:Preoperative Period; D014280:Triglycerides / Q000097:blood; D014336:Troponin / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014336:Troponin; D002784:Cholesterol