title: Oxidants in Acute and Chronic Lung Disease.
abstract: Oxidants play an important role in homeostatic function, but excessive oxidant generation has an adverse effect on health. The manipulation of Reactive Oxygen Species (ROS) can have a beneficial effect on various lung pathologies. However indiscriminate uses of anti-oxidant strategies have not demonstrated any consistent benefit and may be harmful. Here we propose that nuanced strategies are needed to modulate the oxidant system to obtain a beneficial result in the lung diseases such as Acute Lung Injury (ALI) and Chronic Obstructive Pulmonary Disease (COPD). We identify novel areas of lung oxidant responses that may yield fruitful therapies in the future.
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Praveen
authors.initials: P
authors.lastname: Mannam
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Anup
authors.initials: A
authors.lastname: Srivastava
authors.affiliation: Pulmonary and Critical Care Medicine, Geisinger Medical center, PA, USA.
authors.forename: Jaya Prakash
authors.initials: JP
authors.lastname: Sugunaraj
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Patty J
authors.initials: PJ
authors.lastname: Lee
authors.affiliation: Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Maor
authors.initials: M
authors.lastname: Sauler
keywords: Acute lung injury; Chronic obstructive pulmonary disease; Oxidant stress; Oxidative phosphorylation; Reactive oxygen species