title: Effect of topical prostaglandin analogues on corneal hysteresis.
abstract: OBJECTIVE
  To evaluate possible changes in corneal hysteresis (CH) after topical treatment with a prostaglandin analogue in medication-naïve eyes.
  
  
  METHODS
  This was a prospective, observational cohort study. Sixty-eight eyes of 68 patients were prospectively included who were newly diagnosed with primary open-angle glaucoma or ocular hypertension in our institution. All patients were treatment-naïve. Patients were evaluated at baseline and after 6 months of treatment with latanoprost in the eye with the lower intraocular pressure (IOP) measured by Goldmann applanation tonometry (GAT). The ocular response analyzer was used to measure CH.
  
  
  RESULTS
  CH increased significantly (p = 0.0001) from 8.96 ± 2.3 mmHg to 9.79 ± 1.97 mmHg, and this increase was correlated significantly (p = 0.0001, r = 0.64, r(2) = 0.41) with the basal CH. We identified a weak but significant (r(2) = 0.06, p = 0.01) relationship between the basal CH and the drug-induced reduction of the GAT IOP. Nevertheless, the increase in the drug-induced CH was not correlated with the decrease in the GAT IOP.
  
  
  CONCLUSIONS
  Treatment with latanoprost increases CH. The CH increase was not correlated with the drug-induced decrease in the GAT IOP, which suggested a direct effect of latanoprost on the viscoelastic corneal properties.
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: Bolívar
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sánchez-Barahona
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.|University of Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Teus
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Castejón
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Paz-Moreno-Arrones
authors.affiliation: Universitary Hospital "Príncipe de Asturias", Alcalá de Henares, Madrid, Spain.
authors.forename: Consuelo
authors.initials: C
authors.lastname: Gutiérrez-Ortiz
authors.affiliation: 3rd University Department of Ophthalmology, Aristotle University, Thessaloniki, Greece.
authors.forename: Dimitrios G
authors.initials: DG
authors.lastname: Mikropoulos
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D003315:Cornea / Q000503:physiopathology*; D063171:Corneal Pachymetry; D004548:Elasticity / Q000502:physiology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy / Q000503:physiopathology; D009883:Ophthalmic Solutions; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D016037:Single-Blind Method; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost
keywords: cornea; corneal hysteresis; intraocular pressure; prostaglandin analogues