title: The Effect of Caffeine Ingestion during Evening Exercise on Subsequent Sleep Quality in Females.
abstract: In a randomised, double-blind, placebo-controlled crossover design, 10 females taking monophasic oral contraceptives completed 90 min intermittent treadmill-running 45 min after ingestion of 6 mg∙kg(-1) body mass anhydrous caffeine or artificial sweetener (placebo). Water (3 mL∙kg(-1)) was provided every 15 min during exercise. Venous blood samples were taken before, during and after exercise, as well as after sleep (~15 h post-ingestion), and levels of caffeine, paraxanthine, theobromine and theophylline were measured using high-performance liquid chromatography. Sleep quality was assessed using the Leeds Sleep Evaluation Questionnaire. Plasma caffeine concentration peaked 100 min after ingestion. Caffeine clearance was 0.95±0.14 mL·min(-1)·kg(-1) while the elimination half-life of caffeine was 17.63±8.06 h. Paraxanthine and theophylline levels were significantly elevated at 15 h with no significant change in theobromine. Sleep latency and subsequent quality of sleep was impaired following caffeine supplementation (P<0.05); there were no differences between trials for how participants were feeling upon awakening. This is the first controlled study to examine caffeine supplementation on sleep quality in female athletes taking a low-dose monophasic oral contraceptive steroid following an intermittent-exercise running protocol. The data shows that female athletes using monophasic oral contraceptive steroids will have impaired sleep quality following evening caffeine ingestion.
authors.affiliation: School of Sport and Exercise, Massey University, Auckland, New Zealand.
authors.forename: A
authors.initials: A
authors.lastname: Ali
authors.affiliation: School of Sport and Exercise, Massey University, Auckland, New Zealand.
authors.forename: J M
authors.initials: JM
authors.lastname: O'Donnell
authors.affiliation: School of Sport and Exercise, Massey University, Palmerston North, New Zealand.
authors.forename: C
authors.initials: C
authors.lastname: Starck
authors.affiliation: Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand.
authors.forename: K J
authors.initials: KJ
authors.lastname: Rutherfurd-Markwick
mesh_terms: D000328:Adult; D002110:Caffeine / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D015444:Exercise; D005080:Exercise Test; D005260:Female; D006801:Humans; D012890:Sleep / Q000187:drug effects*; D013805:Theobromine / Q000097:blood; D013806:Theophylline / Q000097:blood; D055815:Young Adult
chemical_list: D003276:Contraceptives, Oral; D002110:Caffeine; D013806:Theophylline; D013805:Theobromine; C021183:1,7-dimethylxanthine