title: [Current Topics on Vitamin D. Vitamin D and chronic kidney disease].
abstract: CKD-MBD is a new clinical concept which defines a systemic disorder of mineral and bone metabolism as a result of CKD. Although various mineral metabolic factors are involved in its pathogenesis, alteration in vitamin D metabolism plays a crucial role among them. Vitamin D receptor activators (VDRAs), which are traditionally considered a cardinal treatment of secondary hyperparathyroidism, have attracted lots of attention for their potential pleiotropic effects through the activation of the vitamin D receptor expressed in multiple organs. In recent years, the deficiency of vitamin D in CKD patients also has received growing interest. The serum 25 (OH) D levels are considered as a useful prognostic marker, and the significances of nutritional vitamin D supplementation are reviewed from a new perspective.
authors.affiliation: Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Japan.
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koizumi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001851:Bone Diseases, Metabolic / Q000188:drug therapy*; D006801:Humans; D018167:Receptors, Calcitriol / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism* / Q000494:pharmacology; D014808:Vitamin D Deficiency / Q000150:complications / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018167:Receptors, Calcitriol; D014807:Vitamin D