title: Regioselective iodoazidation of alkynes: synthesis of α,α-diazidoketones.
abstract: Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN3), leading to α,α-diazidoketones via the regioselective addition of IN3 to alkynes. Huisgen cyclization of α,α-diazidoketones generated bis-triazole compounds.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hiroshima International University , 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Okamoto
authors.forename: Takuya
authors.initials: T
authors.lastname: Sueda
authors.forename: Hideki
authors.initials: H
authors.lastname: Minami
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Miwa
authors.forename: Reiko
authors.initials: R
authors.lastname: Yanada
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D012821:Silanes / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D007659:Ketones; D012821:Silanes; D013388:Succinimides; D014230:Triazoles; C438544:azidotrimethylsilane; C008155:N-iodosuccinimide