title: Novel negative pressure wound therapy with instillation and the management of diabetic foot infections.
abstract: OBJECTIVE
  The use of negative pressure wound therapy with instillation (NPWTi) in complex or difficult-to-treat acute and chronic wounds has expanded rapidly since the introduction of commercially available NPWTi systems. We summarize the evidence related to NPWTi and particularly focus on the application of this technology in diabetic foot ulcers, diabetic foot infections and postoperative diabetic wounds.
  
  
  RESULTS
  The benefits of negative pressure wound therapy (NPWT) are well documented in the treatment of complex acute and chronic wounds, including noninfected postoperative diabetic wounds and diabetic foot ulcers. Combining intermittent wound irrigation with NPWT may offer additional benefits compared to NPWT alone, including further reduction of wound bed bioburden, increased granulation tissue formation and provision of wound irrigation in a sealed environment, thus preventing potential cross-contamination events. Recently, available evidence suggests that adjunctive NPWTi may be superior to standard NPWT in the management of diabetic infections following surgical debridement and may promote granulation tissue formation in slow-to-heal wounds.
  
  
  CONCLUSIONS
  Available evidence relating to the utilization of NPWTi in diabetic foot infections is promising but limited in quality, being derived mostly from case series or small retrospective or prospective studies. In order to confirm or refute the potential benefits of NPWTi in this patient cohort, well designed randomized controlled studies are required that compare NPWTi to NPWT or standard wound care methodologies.
authors.affiliation: Department of Microbiology, Hampshire Hospitals NHS Foundation Trust, Royal Hampshire County Hospital, Winchester, UK.
authors.forename: Adam P
authors.initials: AP
authors.lastname: Dale
authors.forename: Kordo
authors.initials: K
authors.lastname: Saeed
mesh_terms: D017719:Diabetic Foot / Q000150:complications* / Q000628:therapy*; D006801:Humans; D054843:Negative-Pressure Wound Therapy / Q000379:methods*; D012874:Skin Diseases, Infectious / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000628:therapy; D007507:Therapeutic Irrigation / Q000379:methods; D016896:Treatment Outcome