title: Redox imaging using genetically encoded redox indicators in zebrafish and mice.
abstract: Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review, we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies, and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.
authors.forename: Michael O
authors.initials: MO
authors.lastname: Breckwoldt
authors.forename: Christine
authors.initials: C
authors.lastname: Wittmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Misgeld
authors.forename: Martin
authors.initials: M
authors.lastname: Kerschensteiner
authors.forename: Clemens
authors.initials: C
authors.lastname: Grabher
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D049452:Green Fluorescent Proteins / Q000235:genetics*; D051379:Mice; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D015027:Zebrafish
chemical_list: D017382:Reactive Oxygen Species; D049452:Green Fluorescent Proteins