title: Aligned Biomimetic Scaffolds as a New Tendency in Tissue Engineering.
abstract: Ideal scaffolds for tissue engineering should have the same characteristics and morphology as the tissue. However, the microstructure of many native tissues has anisotropic characteristics, and the extracellular matrix has an orderly arrangement. Thus, aligned biomimetic scaffolds, a class of directional scaffolds, were proposed and researched to further mimic the permutations of tissue. This review covers the biomaterials, technology for the aligned biomimetic scaffolds and applications in tissue engineering. The aligned biomimetic scaffolds are extremely promising for tissue engineering because they can align the directions of cell growth, affect gene expression and significantly enhance cell reprogramming efficiency.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Wuhan 430079, People's Republic of China. shuhuans@aliyun.com.
authors.forename: Shuhuan
authors.initials: S
authors.lastname: Shang
authors.forename: Chengzhang
authors.initials: C
authors.lastname: Li
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D040761:Biomimetic Materials; D005109:Extracellular Matrix; D006801:Humans; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials