title: Clinical, imaging and histopathological features of isolated CNS lymphomatoid granulomatosis.
abstract: Lymphomatoid granulomatosis is a rare systemic angiocentric/angiodestructive, B cell lymphoproliferative disorder. Central nervous system involvement occurs as part of systemic disease. Isolated central nervous system disease is rare with only few case reports. A 53-year-old male presented with progressive cognitive decline, extrapyramidal features, and altered sensorium with seizures over the last 4 years. His magnetic resonance imaging (MRI) of brain showed multiple small enhancing nodules in subependymal/ependymal regions and along the vessels. Brain biopsy showed atypical lymphohistiocytic infiltrate suggestive of lymphomatoid granulomatosis. There was no evidence of systemic disease; thus, isolated central nervous system lymphomatoid granulomatosis was diagnosed.
authors.affiliation: Department of Neurological Sciences, Section of Neurology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Patil
authors.affiliation: Department of Neurological Sciences, Section of Neurology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Mathew
authors.initials: M
authors.lastname: Alexander
authors.affiliation: Department of Neurological Sciences, Section of Neurosurgery, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Bijesh
authors.initials: B
authors.lastname: Nair
authors.affiliation: Department of Neurological Sciences, Section of Neuropathology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Geeta
authors.initials: G
authors.lastname: Chacko
authors.affiliation: Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sunithi
authors.initials: S
authors.lastname: Mani
authors.affiliation: Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India.
authors.forename: Sniya
authors.initials: S
authors.lastname: Sudhakar
keywords: Lymphomatoid granulomatosis; lympho proliferative disorder; nodular enhancing lesions