title: Access to biaryl sulfonamides by palladium-catalyzed intramolecular oxidative coupling and subsequent nucleophilic ring opening of heterobiaryl sultams with amines.
abstract: The installation of sulfonamide pharmacophores on heterobiaryls has successfully been executed by a previously unknown palladium-catalyzed intramolecular oxidative coupling in N-arylsulfonyl heterocycles followed by novel ring opening of heterobiaryl sultams with amine nucleophiles. The protocol has a wide scope of substrates warranting broad applications in the synthesis of heterobiaryls containing an o-sulfonyl or carboxyl functional group.
authors.affiliation: Department of Pharmaceutical Technology (Process Chemistry), National Institute of Pharmaceutical Education and Research , S. A. S. Nagar, Punjab 160062, India.
authors.forename: Joydev K
authors.initials: JK
authors.lastname: Laha
authors.forename: Neetu
authors.initials: N
authors.lastname: Dayal
authors.forename: Krupal P
authors.initials: KP
authors.lastname: Jethava
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Prajapati
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009282:Naphthalenesulfonates / Q000737:chemistry*; D058451:Oxidative Coupling; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D009282:Naphthalenesulfonates; D013449:Sulfonamides; D010165:Palladium; C016768:naphthosultone