title: Gadolinium-based nanoparticles for theranostic MRI-radiosensitization.
abstract: A rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents. Indeed, they display high relaxivity, adapted biodistribution and passive uptake in the tumor thanks to enhanced permeability and retention effect. In addition to these imaging properties, it has been recently shown that they can act as effective radiosensitizers under different types of irradiation (radiotherapy, neutron therapy or hadron therapy). These new therapeutic modalities pave the way to therapy guided by imaging and to personalized medicine.
authors.affiliation: Institut Lumière Matière, UMR5306 Université Lyon 1-CNRS, Université de Lyon, 69622 Villeurbanne cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Lux
authors.affiliation: Institut Lumière Matière, UMR5306 Université Lyon 1-CNRS, Université de Lyon, 69622 Villeurbanne cedex, France.
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.affiliation: Centre de Résonance Magnétique des Systèmes Biologiques, CNRS UMR5536, Université Bordeaux, Bordeaux, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bianchi
authors.affiliation: Centre de Résonance Magnétique des Systèmes Biologiques, CNRS UMR5536, Université Bordeaux, Bordeaux, France.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Crémillieux
authors.affiliation: Institut UTINAM, UMR6213 UFC-CNRS, Université de Franche-Comté, Besançon cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.affiliation: Institut Lumière Matière, UMR5306 Université Lyon 1-CNRS, Université de Lyon, 69622 Villeurbanne cedex, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
mesh_terms: D003287:Contrast Media / Q000627:therapeutic use; D005682:Gadolinium / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D011859:Radiography; D000068936:Theranostic Nanomedicine; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D011838:Radiation-Sensitizing Agents; D005682:Gadolinium
keywords: MRI; gadolinium; multimodality; nanoparticles; oncology; radiotherapy; theranostic