title: Renal and neurological response with eculizumab in a patient with transplant associated thrombotic microangiopathy after allogeneic hematopoietic progenitor cell transplantation.
abstract: Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenge after allogeneic hematopoietic progenitor cell transplantation, considering the diagnostic uncertainties and lack of established treatment. We report a 43-year-old male patient who was diagnosed as TA-TMA after allogeneic progenitor cell transplantation for a progressive ALK negative anaplastic large cell lymphoma and responded to eculizumab with dramatically improving neurological status and renal function. Rapid neurological and renal recovery achieved after eculizumab could support a possible relationship between complement activation and TA-TMA. Eculizumab should be a reasonable treatment approach in patients with TA-TMA after allogeneic hematopoietic progenitor cell transplantation.
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Ömür Gökmen
authors.initials: ÖG
authors.lastname: Sevindik
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: İnci
authors.initials: İ
authors.lastname: Alacacıoğlu
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Katgı
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Şerife Medeni
authors.initials: ŞM
authors.lastname: Solmaz
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Celal
authors.initials: C
authors.lastname: Acar
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Özden
authors.initials: Ö
authors.lastname: Pişkin
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Özcan
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Ündar
authors.affiliation: Department of Hematology, Dokuz Eylül University, 35340 Izmir, Turkey.
authors.forename: Güner Hayri
authors.initials: GH
authors.lastname: Özsan