title: BUB1B promotes multiple myeloma cell proliferation through CDC20/CCNB axis.
abstract: Multiple myeloma (MM) is the second most common hematopoietic malignancy characterized by plasma cell proliferative disorder. In this study, we disclosed that expression of BUB1B significantly increased in high-risk myeloma patients especially in the most aggressive myeloma genetic subgroups of proliferation. Increased BUB1B expression promotes MM cell proliferation. Mechanism study showed that BUB1B expression was highly correlated to CDC20 and CCNB1/2 expression in MM cells, leading to increased MM cell proliferation. Therefore, BUB1B may be a potential target for MM treatment especially for high-risk MM patients.
authors.affiliation: State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China, yangye876@sina.com.
authors.forename: Ye
authors.initials: Y
authors.lastname: Yang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Gu
authors.forename: Chen
authors.initials: C
authors.lastname: Luo
authors.forename: Fei
authors.initials: F
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000069286:Bortezomib / Q000494:pharmacology; D064199:Cdc20 Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D056744:Cyclin B1 / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: C534699:CCNB1 protein, human; D064199:Cdc20 Proteins; D056744:Cyclin B1; C577488:CDC20 protein, human; D000069286:Bortezomib; C584277:BUB1 protein, human; D017346:Protein Serine-Threonine Kinases