title: Intraperirhinal cortex administration of the synthetic cannabinoid, HU210, disrupts object recognition memory in rats.
abstract: Cannabinoids disrupt learning and memory in human and nonhuman participants. Object recognition memory, which is particularly susceptible to the impairing effects of cannabinoids, relies critically on the perirhinal cortex (PRh); however, to date, the effects of cannabinoids within PRh have not been assessed. In the present study, we evaluated the effects of localized administration of the synthetic cannabinoid, HU210 (0.01, 1.0 μg/hemisphere), into PRh on spontaneous object recognition in Long-Evans rats. Animals received intra-PRh infusions of HU210 before the sample phase, and object recognition memory was assessed at various delays in a subsequent retention test. We found that presample intra-PRh HU210 dose dependently (1.0 μg but not 0.01 μg) interfered with spontaneous object recognition performance, exerting an apparently more pronounced effect when memory demands were increased. These novel findings show that cannabinoid agonists in PRh disrupt object recognition memory.
authors.affiliation: aDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario, Canada bInstitute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, Israel.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Sticht
authors.forename: Derek L
authors.initials: DL
authors.lastname: Jacklin
authors.forename: Raphael
authors.initials: R
authors.lastname: Mechoulam
authors.forename: Linda A
authors.initials: LA
authors.lastname: Parker
authors.forename: Boyer D
authors.initials: BD
authors.lastname: Winters
mesh_terms: D000818:Animals; D063386:Cannabinoid Receptor Agonists / Q000008:administration & dosage*; D013759:Dronabinol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans; D021641:Recognition, Psychology / Q000187:drug effects*; D013702:Temporal Lobe / Q000187:drug effects*
chemical_list: D063386:Cannabinoid Receptor Agonists; D013759:Dronabinol; C062018:HU 211