title: PfRH5 as a candidate vaccine for Plasmodium falciparum malaria.
abstract: PfRH5 has recently emerged as a strong vaccine candidate for Plasmodium falciparum malaria. Antibodies inhibit invasion of erythrocytes by merozoites and blood-stage replication, and PfRH5 is a significant target of acquired human immunity. Recent studies have shown protective efficacy of PfRH5 vaccines in a non-human primate model of malaria.
authors.affiliation: Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia.
authors.forename: Damien R
authors.initials: DR
authors.lastname: Drew
authors.affiliation: Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia; Department of Microbiology, Monash University, Victoria, Australia. Electronic address: beeson@burnet.edu.au.
authors.forename: James G
authors.initials: JG
authors.lastname: Beeson
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000517:prevention & control*; D011323:Primates; D016052:Protozoan Vaccines / Q000235:genetics* / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D002352:Carrier Proteins; D016052:Protozoan Vaccines; C531020:RH5 protein, Plasmodium falciparum
keywords: PfRH5; Plasmodium falciparum; invasion; malaria; vaccines