title: Discovery of hydroxyaniline amides as selective Extracellular Regulated Kinase (Erk) inhibitors.
abstract: Starting from weak μM hits identified through affinity based Automated Ligand Identification System (ALIS) screenings, double digit nM hydroxyaniline amide Erk inhibitors were discovered. This class of compounds had the unique dual mechanism of inhibiting activated and non-activated forms of Erk. They generally had high degree of selectivity in kinase panel tested.
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: Hugh Y
authors.initials: HY
authors.lastname: Zhu
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: Jagdish
authors.initials: J
authors.lastname: Desai
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
authors.forename: Yongqi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: Alan
authors.initials: A
authors.lastname: Cooper
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: James
authors.initials: J
authors.lastname: Wang
authors.affiliation: Discovery Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
authors.forename: Jerry
authors.initials: J
authors.lastname: Shipps
authors.affiliation: Discovery Oncology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Samatar
authors.affiliation: Discovery Oncology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: Donna
authors.initials: D
authors.lastname: Carr
authors.affiliation: Discovery Oncology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.
authors.forename: William
authors.initials: W
authors.lastname: Windsor
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000627:Aminophenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055808:Drug Discovery; D006801:Humans; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000627:Aminophenols; D047428:Protein Kinase Inhibitors; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1
keywords: ALIS; Erk; Extracellular regulated kinase; MAPK; NeoMorph