title: Relation of red cell distribution width to contrast-induced acute kidney injury in patients undergoing a primary percutaneous coronary intervention.
abstract: OBJECTIVE
  We investigated the utility of the preprocedural red cell distribution width (RDW) for predicting contrast-induced acute kidney injury (CI-AKI) in patients with ST-segment-elevation myocardial infarction (STEMI) who underwent a primary percutaneous coronary intervention.
  
  
  METHODS
  A total of 630 consecutive patients who were routinely referred to coronary angiography for STEMI were included in the present study.
  
  
  RESULTS
  CI-AKI was observed in 79 patients (12.5%). The RDW, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and the mean platelet volume were significantly higher in the CI-AKI group than in the non-CI-AKI group (P<0.001, P=032, P=0.025, and P=0.039, respectively). Serum total bilirubin and direct bilirubin levels were not different among the study groups. Using multivariate logistic regression analysis, we found that left ventricular ejection fraction [odds ratio (OR)=0.972, 95% confidence interval (CI) 0.945-0.998, P=0.033], estimated glomerular filtration rate (OR=0.970, 95% CI 0.959-0.981, P<0.001), contrast volume (OR=1.007, 95% CI 1.002-1.012, P=0.009), and RDW (OR=1.406, 95% CI 1.120-1.792, P=0.005) were independent predictors of CI-AKI.
  
  
  CONCLUSIONS
  Red blood cell distribution width, an inexpensive and easily measurable laboratory variable, is associated independently with the development of CI-AKI. Our data suggest that RDW may be a useful marker in CI-AKI risk stratification.
authors.affiliation: aDepartment of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla bDepartment of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital cDepartment of Cardiology, Bağcılar Education and Research Hospital dDepartment of Cardiology, Acıbadem University School of Medicine, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.forename: Omer
authors.initials: O
authors.lastname: Celik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Altun
authors.forename: Burak
authors.initials: B
authors.lastname: Ayca
authors.forename: Derya
authors.initials: D
authors.lastname: Ozturk
authors.forename: Seckin
authors.initials: S
authors.lastname: Satilmis
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ayaz
authors.forename: Omer
authors.initials: O
authors.lastname: Tasbulak
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D004909:Erythrocyte Indices; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy*; D062645:Percutaneous Coronary Intervention; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D001663:Bilirubin