title: [The influence of testosterone and β-estradiol on T-lymphocytes activation associated with IL-2 production and expression of CD25 (IL-2Rα) molecules].
abstract: We have shown that testosterone and β-estradiol in vitro have effects on naïve (CD45RA+) and priming (CD45RO+) T-lymphocytes, which associated with the production of IL-2 and CD25/IL-2Rα expression. Testosterone can inhibit naïve and priming T-cell function activity in our study. Moreover it was shown that naïve lymphocytes are more sensitive to testosterone than primed. We have found dose dependent suppressive β-estradiol effect on IL-2 production by activated CD45RA+ and CD45RO+ lymphocytes which leads to uniform decreasing CD25-positive T-cells number.
authors.forename: A A
authors.initials: AA
authors.lastname: Gutsol
authors.forename: N A
authors.initials: NA
authors.lastname: Sokhonevich
authors.forename: K A
authors.initials: KA
authors.lastname: Kofanova
authors.forename: L S
authors.initials: LS
authors.lastname: Litvinova
mesh_terms: D000328:Adult; D004306:Dose-Response Relationship, Immunologic; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression; D006801:Humans; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000276:immunology; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics* / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D018655:Lymphocyte Count; D008297:Male; D061251:Primary Cell Culture; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D013739:Testosterone / Q000494:pharmacology*
chemical_list: C508017:IL2RA protein, human; D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D013739:Testosterone; D004958:Estradiol; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human