title: Nanomedicine as an innovative therapeutic strategy for pediatric cancer.
abstract: Childhood cancer is the leading cause of mortality in children between 1 and 14 years of age. Malignancy accounts for 18 % of overall childhood mortality. Therapeutic advances in the field of pediatric oncology have helped to increase survival. Nanotechnology is the modification of materials at a nanoscale and can be used to deliver therapeutic agents. Examples of nanotechnology applications are organic self-assembled amphiphilic polymers, non-organic nanocarriers such as nanotubes and quantum dots. Each of these has their own utility in different settings. Application of nanotechnology in medicine has been extensively studied. Examples of pediatric tumors that received special attention are: neuroblastoma, retinoblastoma, central nervous system tumors and musculoskeletal tumors. This review will summarize the application of nanomedicine as an innovative management strategy in pediatric oncology.
authors.affiliation: Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Essa Mohd
authors.initials: EM
authors.lastname: Aleassa
authors.forename: Malcolm
authors.initials: M
authors.lastname: Xing
authors.forename: Richard
authors.initials: R
authors.lastname: Keijzer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D010372:Pediatrics / Q000379:methods*