title: Photoacoustic-based nanomedicine for cancer diagnosis and therapy.
abstract: Photoacoustic imaging is the latest promising diagnostic modality that has various advantages such as high spatial resolution, deep penetration depth, and use of non-ionizing radiation. It also employs a non-invasive imaging technique and optically functionalized imaging. The goal of this study was to develop a nanomedicine for simultaneous cancer therapy and diagnosis based on photoacoustic imaging. Human serum albumin nanoparticles loaded with melanin and paclitaxel (HMP-NPs) were developed using the desolvation technique. The photoacoustic-based diagnostic and chemotherapeutic properties of HMP-NPs were evaluated through in vitro and in vivo experiments. The size and zeta potential of the HMP-NPs were found to be 192.8±21.11nm and -22.2±4.39mV, respectively. In in vitro experiments, HMP-NPs produced increased photoacoustic signal intensity because of the loaded melanin and decreased cellular viability because of the encapsulated paclitaxel, compared to the free human serum albumin nanoparticles (the control). In vivo experiments showed that the HMP-NPs efficiently accumulated inside the tumor, resulting in the enhanced photoacoustic signal intensity in the tumor site, compared to the normal tissues. The in vivo chemotherapy study demonstrated that HMP-NPs had the capability to treat cancer for an extended period. In conclusion, HMP-NPs were simultaneously capable of photoacoustic diagnostic and chemotherapy against cancer.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea.
authors.forename: Changbeom
authors.initials: C
authors.lastname: Sim
authors.affiliation: Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea.
authors.forename: Haemin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea.
authors.forename: Hyungwon
authors.initials: H
authors.lastname: Moon
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea.
authors.forename: Hohyeon
authors.initials: H
authors.lastname: Lee
authors.affiliation: Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea; Sogang Institutes of Advanced Technology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chang
authors.affiliation: Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea; Interdisciplinary Program of Integrated Biotechnology, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 121-742, South Korea. Electronic address: hyuncheol@sogang.ac.kr.
authors.forename: Hyuncheol
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use; D001940:Breast / Q000187:drug effects / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008543:Melanins / Q000008:administration & dosage* / Q000627:therapeutic use; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000008:administration & dosage* / Q000627:therapeutic use; D061088:Photoacoustic Techniques / Q000379:methods*; D012709:Serum Albumin / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D008543:Melanins; D012709:Serum Albumin; D017239:Paclitaxel
keywords: Cancer diagnosis; Chemotherapy; Nanomedicine; Photoacoustics; Theranostics