title: A fermented sorghum/millet-based beverage, Obiolor, extenuates high-fat diet-induced dyslipidaemia and redox imbalance in the livers of rats.
abstract: BACKGROUND
  Obiolor, a non-alcoholic beverage produced from fermented sorghum and millet malts, is widely consumed on a daily basis by the Igala tribe in Nigeria and is closely associated with good health. The effect of Obiolor on dyslipidaemia, protein oxidation, lipid peroxidation and DNA fragmentation in the liver of rats fed a high-fat diet was investigated.
  
  
  RESULTS
  High-fat diet-mediated alterations in liver and serum total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density cholesterol and very low-density lipoprotein cholesterol were significantly (P < 0.05) reversed by Obiolor. The beverage increased the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase in the liver of rats. These increases significantly (P < 0.05) attenuated the high-fat diet-mediated decrease in antioxidant enzymes. High-fat diet-mediated elevations in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl and DNA fragmentation in the livers of rats were lowered by the beverage.
  
  
  CONCLUSIONS
  This study showed that Obiolor extenuated high-fat diet-mediated dyslipidaemia, protein oxidation, lipid peroxidation and DNA fragmentation in rats.
authors.affiliation: Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria.
authors.forename: Taofeek O
authors.initials: TO
authors.lastname: Ajiboye
authors.affiliation: Antioxidants, Free Radicals and Toxicology Research Laboratory, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria.
authors.forename: Ganiyat A
authors.initials: GA
authors.lastname: Iliasu
authors.affiliation: Antioxidants, Free Radicals and Toxicology Research Laboratory, Department of Chemical Sciences, Fountain University, Osogbo, Nigeria.
authors.forename: Abdulwasiu O
authors.initials: AO
authors.lastname: Adeleye
authors.affiliation: Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria.
authors.forename: Oluwayemisi B
authors.initials: OB
authors.lastname: Ojewuyi
authors.affiliation: Department of Home Economics and Food Sciences, University of Ilorin, Ilorin, Nigeria.
authors.forename: Fausat L
authors.initials: FL
authors.lastname: Kolawole
authors.affiliation: Industrial Microbiology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria.
authors.forename: Sharafa A
authors.initials: SA
authors.lastname: Bello
authors.affiliation: Industrial Microbiology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria.
authors.forename: Aisha O
authors.initials: AO
authors.lastname: Mohammed
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001628:Beverages; D002374:Catalase / Q000378:metabolism; D053938:DNA Fragmentation; D059305:Diet, High-Fat; D050171:Dyslipidemias / Q000178:diet therapy* / Q000209:etiology; D005285:Fermentation; D055951:Functional Food; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000032:analysis / Q000097:blood; D008099:Liver / Q000737:chemistry*; D008297:Male; D000066928:Millets / Q000737:chemistry*; D009549:Nigeria; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D045868:Sorghum / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008055:Lipids; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
keywords: Obiolor; dyslipidaemia; high fat diet; lipid peroxidation; oxidative stress; protein oxidation