title: Phages targeting infected tissues: novel approach to phage therapy.
abstract: While the true efficacy of phage therapy still requires formal confirmation in clinical trials, it continues to offer realistic potential treatment in patients in whom antibiotics have failed. Novel developments and approaches are therefore needed to ascertain that future clinical trials would evaluate the therapy in its optimal form thus allowing for reliable conclusions regarding the true value of phage therapy. In this article, we present our vision to develop and establish a bank of phages specific to most threatening pathogens and armed with homing peptides enabling their localization in infected tissues in densities assuring efficient and stable eradication of infection.
authors.affiliation: L Hirszfeld Institute of Immunology & Experimental Therapy, Polish Academy of Science, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Górski
authors.forename: Krystyna
authors.initials: K
authors.lastname: Dąbrowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Hodyra-Stefaniak
authors.forename: Jan
authors.initials: J
authors.lastname: Borysowski
authors.forename: Ryszard
authors.initials: R
authors.lastname: Międzybrodzki
authors.forename: Beata
authors.initials: B
authors.lastname: Weber-Dąbrowska
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001424:Bacterial Infections / Q000628:therapy*; D001435:Bacteriophages / Q000502:physiology*; D006801:Humans; D010455:Peptides
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides
keywords: antibiotic resistance; homing peptides; phage display; phage therapy