title: Chemoselective synthesis of β-ketophosphonates using lithiated α-(trimethylsilyl)methylphosphonate.
abstract: A highly chemoselective synthesis of β-ketophosphonates from pentafluorophenyl esters and lithiated methyl α-(trimethylsilyl)methylphosphonate has been developed. This mild lithiated phosphonate reagent allows the synthesis of functionalized β-ketophosphonates in the presence of unactivated esters with high yields. This method has been compared with the standard lithiated methylphosphonate reagent.
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231-ESPCI ParisTech/CNRS/PSL Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Simon
authors.initials: S
authors.lastname: Specklin
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231-ESPCI ParisTech/CNRS/PSL Research University, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy