title: A population-based single nucleotide polymorphism array analysis of genomic aberrations in younger adult acute lymphoblastic leukemia patients.
abstract: Adult acute lymphoblastic leukemia (ALL) is characterized by a high frequency of abnormal karyotypes some of which are related to outcome. Single nucleotide polymorphism (SNP) array analysis provides a highly sensitive platform to detect large and small genomic aberrations. SNP array profiling data in adult ALL are limited and further systematic studies of this patient group are needed. We performed a population-based SNP array analysis of genomic aberrations and their influence on survival in 66 Lithuanian 18-65 year old ALL patients diagnosed between 2007 and 2013. Most aberrations were detected in chromosome arm 9p, chromosome arm 6q, chromosome arm 13q, and chromosome 17. The recurrently targeted copy number abnormalities involved several leukemia-related genes-CDKN2A/B, MLL, IKZF1, PAX5, RB1, TP53, and ETV6. We identified several new recurrent aberrations with possible new target genes: SMARCA4 in 19p13.2, RNASEL in 1q25.3, ARHGEF12 in 11q23.3, and LYL1 in 19p13.2. Aberrations in chromosome 13 and the RB1 gene as well as CDKN2A/B gene status were related to the outcome.
authors.affiliation: Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
authors.forename: Vaidas
authors.initials: V
authors.lastname: Dirse
authors.forename: Agne
authors.initials: A
authors.lastname: Bertasiute
authors.forename: Egle
authors.initials: E
authors.lastname: Gineikiene
authors.forename: Tadas
authors.initials: T
authors.lastname: Zvirblis
authors.forename: Ruta
authors.initials: R
authors.lastname: Dambrauskiene
authors.forename: Rolandas
authors.initials: R
authors.lastname: Gerbutavicius
authors.forename: Elona
authors.initials: E
authors.lastname: Juozaityte
authors.forename: Ligita
authors.initials: L
authors.lastname: Malciute
authors.forename: Kajsa
authors.initials: K
authors.lastname: Paulsson
authors.forename: Laimonas
authors.initials: L
authors.lastname: Griskevicius
mesh_terms: D000293:Adolescent; D000328:Adult; D002877:Chromosomes, Human; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D055815:Young Adult
chemical_list: D016159:Tumor Suppressor Protein p53