title: Cost-effectiveness of eplerenone plus standard treatment compared with standard treatment in patients with myocardial infarction complicated by left ventricular systolic dysfunction and heart failure in the Netherlands.
abstract: OBJECTIVE
  Following the results of the EPHESUS study in patients with heart failure after myocardial infarction, a cost-effectiveness analysis was undertaken from a Dutch societal perspective to evaluate the lifetime benefits and costs of eplerenone as add-on to standard treatment.
  
  
  METHODS
  Life-years gained in the eplerenone arm during the trial period were extrapolated to lifetime life-years gained using three sources of life expectancy data (Framingham Heart Study, Saskatchewan Health Database and Worcester Heart Attack Registry). Resource use measured included direct medical costs of hospitalisation, medications including eplerenone, outpatient diagnostic tests and procedures, and emergency room visits. Incremental cost-effectiveness ratios were calculated for life-years gained and quality-adjusted life-years gained.
  
  
  RESULTS
  Eplerenone prolonged lifetime survival by five weeks at an additional cost of €803. The incremental cost-effectiveness ratio was about €8000 per life-year gained, well below the only published Dutch benchmark for cost-effectiveness of €18,000. Probabilistic sensitivity analyses showed the results to be robust when varying the discount rate applied to benefits and costs, the hospitalisation costs, and the source of life expectancy data used.
  
  
  CONCLUSIONS
  Treatment with adjunctive eplerenone is effective in preventing deaths and prolonging life.
authors.forename: M L L
authors.initials: ML
authors.lastname: van Genugten
authors.forename: W S
authors.initials: WS
authors.lastname: Weintraub
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: A A
authors.initials: AA
authors.lastname: Voors
keywords: aldosterone blockade; cost-effectiveness; eplerenone; heart failure