title: L-Carnosine's dose-dependent effects on muscle sympathetic nerves and blood flow.
abstract: L-Carnosine is synthesized in mammalian muscles and brain and affects autonomic neurotransmission and physiological phenomena. To clarify the role of l-carnosine, the effects of intraduodenal administration of l-carnosine on muscle sympathetic nerve activity (muscle-SNA) and blood flow (BF) were examined. The changes in muscle-SNA and BF were examined using electrophysiological and Doppler flowmeter in urethane-anesthetized rats. The effect of propranolol, a β-adrenergic antagonist, on the increase in muscle BF due to l-carnosine was also examined. Low dose (1μg/300g body weight [bw]) of l-carnosine increased both muscle-SNA and muscle BF, while high dese (100mg/300g bw) of l-carnosine decreased both muscle-SNA and muscle BF. Furthermore, propranolol eliminated the increase in muscle BF caused by a low dose of l-carnosine. These results suggest that l-carnosine has dose-dependent effects on muscle BF via changes in muscle-SNA, and the β-adrenergic receptor is implicated in the increase in muscle BF due to l-carnosine.
authors.affiliation: ANBAS Corporation, 4-12-10 Toyosaki Kita-ku, Osaka 531-0072, Japan. Electronic address: yhorii@anbas.co.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horii
authors.affiliation: ANBAS Corporation, 4-12-10 Toyosaki Kita-ku, Osaka 531-0072, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Fujisaki
authors.affiliation: ANBAS Corporation, 4-12-10 Toyosaki Kita-ku, Osaka 531-0072, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Fuyuki
authors.affiliation: ANBAS Corporation, 4-12-10 Toyosaki Kita-ku, Osaka 531-0072, Japan; Osaka University, 1-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagai
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000187:drug effects* / Q000294:innervation; D011433:Propranolol / Q000494:pharmacology; D017208:Rats, Wistar; D012039:Regional Blood Flow; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D002336:Carnosine; D011433:Propranolol
keywords: Muscle blood flow; Propranolol; Rats; Skeletal muscle; Sympathetic nerve activity; β-Adrenergic receptor