title: Mass spectrometry in leukemia research and treatment.
abstract: Mass spectrometry (MS) is a complex analytical chemistry tool that allows qualitative and quantitative assessments of the components of complex chemical compounds. Applications of MS in medicine include the identification and quantification of drugs and metabolites; identification of proteins, biopolymers and disease markers and investigation of differential protein expression and proteins altered by mutations and/or post-translational changes. A variety of MS methods and technologies now play valuable and expanding roles in the diagnosis and monitoring of acute leukemia, as well as in identification of therapeutic targets and biomarkers, drug discovery, and other important areas of leukemia research. The objective of this review is to present a clinically oriented review of the roles of MS in the research, diagnosis and therapy of acute leukemia.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, Icahn School of Medicine of Mount Sinai, New York, NY, 10029, USA.
authors.forename: John
authors.initials: J
authors.lastname: Roboz
authors.forename: Gail J
authors.initials: GJ
authors.lastname: Roboz
mesh_terms: D055808:Drug Discovery; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000628:therapy*; D013058:Mass Spectrometry / Q000379:methods*
keywords: MALDI-TOF; acute myeloid leukemia; genotyping; mass spectrometry; myelodysplastic syndrome; proteomics; quantification techniques; tyrosine kinase inhibitors