title: Eculizumab in pregnancy-associated atypical hemolytic uremic syndrome: insights for optimizing management.
abstract: Pregnancy-associated atypical hemolytic uremic syndrome is a systemic disease associated with high morbidity and mortality rates, caused by dysregulation of the alternative complement pathway, leading to uncontrolled complement activation resulting in thrombotic microangiopathy. This condition can be effectively treated by anti-C5 therapy, which controls complement activation. Treatment can be safely discontinued after complete remission and resolution of the precipitating cause, especially in patients with a low-risk genetic profile.
authors.affiliation: Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain. desousa@clinic.ub.es.
authors.forename: Erika
authors.initials: E
authors.lastname: De Sousa Amorim
authors.affiliation: Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Blasco
authors.affiliation: Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Quintana
authors.affiliation: Histopathology Department, Hospital Clinic, Barcelona, Spain.
authors.forename: Manel
authors.initials: M
authors.lastname: Sole
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, 28040, Madrid, Spain.
authors.forename: Santiago Rodríguez
authors.initials: SR
authors.lastname: de Cordoba
authors.affiliation: Nephrology Department, Hospital Clinic, Calle Villarroel, 170, 08036, Barcelona, Spain.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Campistol
mesh_terms: D000328:Adult; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D065766:Atypical Hemolytic Uremic Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D001706:Biopsy; D003937:Diagnosis, Differential; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C481642:eculizumab
keywords: Eculizumab; Hemolytic uremic syndrome; Post-partum; Pregnancy