title: Imaging areas of retinal nonperfusion in ischemic branch retinal vein occlusion with swept-source OCT microangiography.
abstract: The authors present the case of a patient with a history of ischemic branch vein occlusion and multimodal imaging of the retinal vasculature by fluorescein angiography (FA) and ultrahigh-speed swept-source optical coherence tomography (SS-OCT) microangiography (SS-OCT laser prototype; 1,050 nm, 100,000 A-scans/second). Multiple images across the macula were acquired (3 × 3 mm cubes in clusters of four repeated B-scans). En face images of the vasculature were generated by implementing an intensity differentiation algorithm. The retinal vasculature as well areas of nonperfusion could be identified precisely at multiple retinal levels. Ultrahigh-speed SS-OCT microangiography provides noninvasive, three-dimensional, high-resolution images of the retinal vasculature including the capillaries.
authors.forename: Laura
authors.initials: L
authors.lastname: Kuehlewein
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.forename: SriniVas R
authors.initials: SR
authors.lastname: Sadda
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D002387:Cataract Extraction; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D007511:Ischemia / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D017075:Laser Coagulation; D008833:Microcirculation; D064847:Multimodal Imaging; D012039:Regional Blood Flow; D012170:Retinal Vein Occlusion / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D012171:Retinal Vessels / Q000473:pathology*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A