title: DNA-ligand interactions gained and lost: light-induced ligand redistribution in a supramolecular cascade.
abstract: A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA. The results point out novel approaches for the control of drug-DNA interactions in DNA-targeting therapy.
authors.affiliation: Department Chemie-Biologie, Organische Chemie II, Universität Siegen, Adolf-Reichwein-Str. 2, 57068 Siegen, Germany. berdnikova@chemie-bio.uni-siegen.de daria@ineos.ac.ru.
authors.forename: Daria V
authors.initials: DV
authors.lastname: Berdnikova
authors.forename: Tseimur M
authors.initials: TM
authors.lastname: Aliyeu
authors.forename: Thomas
authors.initials: T
authors.lastname: Paululat
authors.forename: Yuri V
authors.initials: YV
authors.lastname: Fedorov
authors.forename: Olga A
authors.initials: OA
authors.lastname: Fedorova
authors.forename: Heiko
authors.initials: H
authors.lastname: Ihmels
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D065546:Drug Liberation; D008024:Ligands; D008027:Light; D047028:Macrocyclic Compounds / Q000737:chemistry*; D046911:Macromolecular Substances; D000099246:Cucurbit(n)urils
chemical_list: D003505:Cyclodextrins; D004247:DNA; D004337:Drug Carriers; D008024:Ligands; D047028:Macrocyclic Compounds; D046911:Macromolecular Substances; D000099246:Cucurbit(n)urils