title: Development and Investigation of a Site Selective Palladium-Catalyzed 1,4-Difunctionalization of Isoprene using Pyridine-Oxazoline Ligands.
abstract: Palladium-catalyzed 1,4-difunctionalizations of isoprene that produce skipped polyenes are reported. Complex isomeric product mixtures are possible as a result of the difficult-to-control migratory insertion of isoprene into a Pd-alkenyl bond, but good site selectivity has been achieved using easily accessible Pyrox ligands. Mechanistic studies suggest that the control of insertion is the result of the unique electronic asymmetry and steric properties of the ligand.
authors.affiliation: Department Of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, USA. ; Tel: +1 801-585-0774.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: McCammant
authors.affiliation: Department Of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, USA. ; Tel: +1 801-585-0774.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Sigman