title: Effect of medicinal plants on wound healing.
abstract: In the United States alone, chronic wounds affect 6.5 million patients. It is expected that the number of chronic wounds will increase worldwide due to the increase in age-related conditions and pathologies such as diabetes, obesity, and cardiovascular diseases. An estimated excess of US$25 billion is spent annually on treatment of chronic wounds, and the burden is rapidly growing due to increasing healthcare costs, an aging population, and a sharp rise in the incidence of diabetes and obesity worldwide. While current therapeutic agents have generally inadequate efficacy and number of serious adverse effects, the medicinal plants have been used in medicine since ancient times and are well known for their abilities to promote wound healing and prevent infection without grave side effects. Thus, herbal therapy may be an alternative strategy for treatment of wounds. The purpose of this review is to provide the verified data on the medicinal plants of the world flora with wound healing activity including the biologically active substances belonging to these herbal preparations and describe in detail the various cellular and molecular mechanisms of their actions.
authors.affiliation: Judea Regional Research & Development Center, Carmel.
authors.forename: Arie
authors.initials: A
authors.lastname: Budovsky
authors.affiliation: Judea Regional Research & Development Center, Carmel.
authors.forename: Ludmila
authors.initials: L
authors.lastname: Yarmolinsky
authors.affiliation: Department of Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Shimon
authors.initials: S
authors.lastname: Ben-Shabat
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017719:Diabetic Foot / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D017048:Health Care Costs; D006801:Humans; D008517:Phytotherapy / Q000191:economics / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts