title: Considerations for the use of human participants in vector biology research: a tool for investigators and regulators.
abstract: A thorough search of the existing literature has revealed that there are currently no published recommendations or guidelines for the interpretation of US regulations on the use of human participants in vector biology research (VBR). An informal survey of vector biologists has indicated that issues related to human participation in vector research have been largely debated by academic, national, and local Institutional Review Boards (IRBs) in the countries where the research is being conducted, and that interpretations and subsequent requirements made by these IRBs have varied widely. This document is intended to provide investigators and corresponding scientific and ethical review committee members an introduction to VBR methods involving human participation and the legal and ethical framework in which such studies are conducted with a focus on US Federal Regulations. It is also intended to provide a common perspective for guiding researchers, IRB members, and other interested parties (i.e., public health officials conducting routine entomological surveillance) in the interpretation of human subjects regulations pertaining to VBR.
authors.affiliation: 1 Department of Biological Sciences, Eck Institute for Global Health , University of Notre Dame, Notre Dame, Indiana.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Achee
authors.forename: Laura
authors.initials: L
authors.lastname: Youngblood
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bangs
authors.forename: James V
authors.initials: JV
authors.lastname: Lavery
authors.forename: Stephanie
authors.initials: S
authors.lastname: James
mesh_terms: D000818:Animals; D001179:Arthropod Vectors; D001695:Biology; D028744:Ethics Committees, Research; D006801:Humans; D010571:Pest Control; D011634:Public Health; D012106:Research; D012108:Research Personnel; D014481:United States
keywords: Entomology; Epidemiology; Risk assessment; Vector; Vector control