title: Versatile communication strategies among tandem WW domain repeats.
abstract: Interactions mediated by short linear motifs in proteins play major roles in regulation of cellular homeostasis since their transient nature allows for easy modulation. We are still far from a full understanding and appreciation of the complex regulation patterns that can be, and are, achieved by this type of interaction. The fact that many linear-motif-binding domains occur in tandem repeats in proteins indicates that their mutual communication is used extensively to obtain complex integration of information toward regulatory decisions. This review is an attempt to overview, and classify, different ways by which two and more tandem repeats cooperate in binding to their targets, in the well-characterized family of WW domains and their corresponding polyproline ligands.
authors.affiliation: Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
authors.forename: Emma Joy
authors.initials: EJ
authors.lastname: Dodson
authors.affiliation: Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
authors.forename: Vered
authors.initials: V
authors.lastname: Fishbain-Yoskovitz
authors.affiliation: Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel.
authors.forename: Shahar
authors.initials: S
authors.lastname: Rotem-Bamberger
authors.affiliation: Department of Microbiology and Molecular Genetics, Institute of Biomedical Research Israel-Canada IMRIC, Faculty of Medicine, Ein Kerem Campus, The Hebrew University of Jerusalem, 91120 Jerusalem, Israel oraf@ekmd.huji.ac.il.
authors.forename: Ora
authors.initials: O
authors.lastname: Schueler-Furman
mesh_terms: D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology; D006801:Humans; D010088:Oxidoreductases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D054730:Protein Interaction Domains and Motifs / Q000235:genetics / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D020080:Tandem Repeat Sequences / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000074584:WW Domain-Containing Oxidoreductase
chemical_list: D025521:Tumor Suppressor Proteins; D010088:Oxidoreductases; D000074584:WW Domain-Containing Oxidoreductase; C486071:WWOX protein, human
keywords: WW domain; WW domain containing oxidoreductase; Yes-associated protein; cooperative binding; peptide-mediated interactions; protein domain repeats; regulation of signaling