title: Resveratrol Protects from Toxin-Induced Parkinsonism: Plethora of Proofs Hitherto Petty Translational Value.
abstract: Parkinson's disease (PD) is a mysterious, chronic, multi-factorial and progressive disorder of the nervous system that is characterized by the selective loss of dopamine-producing cells of the substantia nigra leading to dopamine deficiency in the striatum. PD is exemplified by oxidative stress, α-synuclein accumulation, mitochondrial dysfunction, defective ubiquitin proteasome system, aberrant autophagy, inflammation, and atypical apoptosis, which eventually lead to slowness of movement, resting tremor, stiffness, and loss of balance. Despite incomprehensible etiology, timely diagnosis, and permanent cure, a handful of synthetic and natural agents rescue from the symptomatic features and delay disease progression. At low doses, a natural polyphenol, trans-3,5,4'-trihydroxystilbene (resveratrol), delays neurodegeneration in the cellular and animal models and lessens oxidative stress, mitochondrial dysfunction, aberrant apoptosis, and defective autophagy. The present article explains neuroprotective efficacy, advantages, and downsides of resveratrol in the conventional and preclinical models. This piece of writing also examines its probable neuroprotective mechanisms and constraints of realistic recital in clinical investigations and likely endeavors to minimize apprehensions.
authors.affiliation: CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001, Uttar Pradesh, India.|Academy of Scientific and Innovative Research, New Delhi, 110 025, India.
authors.forename: Mohd Sami
authors.initials: MS
authors.lastname: Ur Rasheed
authors.affiliation: CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001, Uttar Pradesh, India.|Academy of Scientific and Innovative Research, New Delhi, 110 025, India.
authors.forename: Manish Kumar
authors.initials: MK
authors.lastname: Tripathi
authors.affiliation: CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001, Uttar Pradesh, India.|Academy of Scientific and Innovative Research, New Delhi, 110 025, India.
authors.forename: Abhishek Kumar
authors.initials: AK
authors.lastname: Mishra
authors.affiliation: CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001, Uttar Pradesh, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Shukla
authors.affiliation: CSIR-Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, 226 001, Uttar Pradesh, India. singhmahendrapratap@rediffmail.com.|Academy of Scientific and Innovative Research, New Delhi, 110 025, India. singhmahendrapratap@rediffmail.com.
authors.forename: Mahendra Pratap
authors.initials: MP
authors.lastname: Singh
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009498:Neurotoxins / Q000633:toxicity*; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000473:pathology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D057170:Translational Research, Biomedical
chemical_list: D018696:Neuroprotective Agents; D009498:Neurotoxins; D013267:Stilbenes; D000077185:Resveratrol
keywords: Cellular models; Parkinsonism; Resveratrol; Rodent models; Translational value