title: [Protein-synthesizing function of neutrophils and lipid-releasing ability of leukocytes in patients with atherosclerosis].
abstract: Concentrations of defensins-alpha, lipoprotein(α), C-reactive protein, proBNP, VII- coagulation factor and von Wilebrandt factor were measured in supernatants of 3-day leukocyte cultures enriched with neutrophils in order to estimate their synthesis in patients with stable angina and atherosclerosis of lower extremities. In addition, in vitro tumor necrosis factor-alpha test was performed. Simultaneously, concentrations of serum interleukine-6, -8, defensins-alpha, C-reactive protein, proBNP, VII-coagulation factor were determined. Neutrophil protein synthesis was impaired in the patients with stable angina. The same was true of defensins-alpha synthesis whereas production of lipoproteins, pro-BNP, C-reactive proteins, IL-8, and von Wilebrandt factor increased. Pathogenetic role of TNF-alpha was demonstrated.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Mishlanov
authors.forename: P Ia
authors.initials: PIa
authors.lastname: Sandakov
authors.forename: A V
authors.initials: AV
authors.lastname: Ronzin
authors.forename: V E
authors.initials: VE
authors.lastname: Vladimirskii
authors.forename: L I
authors.initials: LI
authors.lastname: Syromiatnikova
authors.forename: T A
authors.initials: TA
authors.lastname: Polovinkina
authors.forename: N N
authors.initials: NN
authors.lastname: Seredenko
authors.forename: O V
authors.initials: OV
authors.lastname: Kharuzina
authors.forename: S L
authors.initials: SL
authors.lastname: Mishlanova
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*