title: Synthesis and antimicrobial activity of N-substituted-β-amino acid derivatives containing 2-hydroxyphenyl, benzo[b]phenoxazine and quinoxaline moieties.
abstract: 3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger.
authors.affiliation: Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania. kristina.mickeviciene@ktu.lt.
authors.forename: Kristina
authors.initials: K
authors.lastname: Mickevičienė
authors.affiliation: Department of Organic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania. ruta.baranauskaite7@gmail.com.
authors.forename: Rūta
authors.initials: R
authors.lastname: Baranauskaitė
authors.affiliation: Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania. kristina.kantminiene@ktu.lt.
authors.forename: Kristina
authors.initials: K
authors.lastname: Kantminienė
authors.affiliation: Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine. vnovikov@polynet.lviv.ua.
authors.forename: Maryna
authors.initials: M
authors.lastname: Stasevych
authors.affiliation: Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine. olkomarovska@gmail.com.
authors.forename: Olena
authors.initials: O
authors.lastname: Komarovska-Porokhnyavets
authors.affiliation: Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine. vnovikov@polynet.lviv.ua.
authors.forename: Volodymyr
authors.initials: V
authors.lastname: Novikov
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000254:growth & development*; D002176:Candida albicans / Q000254:growth & development*; D009161:Mycobacterium / Q000254:growth & development*; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000596:Amino Acids; D000890:Anti-Infective Agents