title: Granular cell tumor of the esophagus with elevated preoperative serum carbohydrate antigen 19-9: a case report.
abstract: A 59-year-old Japanese man was admitted to our hospital for treatment of a submucosal tumor of the esophagus detected by upper gastrointestinal endoscopy and computed tomography (CT). Endoscopic examination revealed a submucosal tumor in the esophagus 35 cm from the incisor teeth. Biopsy of the lesions identified granular cell tumor. CT indicated a projecting and slightly enhanced homogenous mass measuring 2.0 × 1.5 cm in the esophagus below the tracheal bifurcation. Serum tumor marker studies revealed elevated carbohydrate antigen (CA) 19-9. Therefore, the tumor was considered to have malignant potential, and surgical resection was performed. The final pathologic diagnosis was a benign granular cell tumor, positive for S-100 protein. The patient was doing well with normal CA 19-9 levels and no recurrence more than 5 years after surgery. To the best of our knowledge, this is the first report of a granular cell tumor with elevated serum CA 19-9.
authors.affiliation: 1 Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yanoma
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Sakurai
authors.forename: Hisanori
authors.initials: H
authors.lastname: Shoji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naitoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood*; D004938:Esophageal Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging; D016586:Granular Cell Tumor / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C578959:carbohydrate antigen 199, human
keywords: Esophagus; Granular cell tumor; Tumor-associated carbohydrate antigens