title: Single gene disorders with craniofacial and oral manifestations.
abstract: Gene and environmental factors are instrumental in genesis of complex and wide range of disorders and syndromes. The newer gene sequencing and other advanced technologies have made our previous knowledge of genetic etiopathogenesis of various disorders more transparent. Single gene disorders refer to the disorders caused due to mutations in a single gene and a fair number of these manifest as craniofacial defects and anomalies. This review is an attempt to give a detailed insight into the varied single gene disorders and syndromes with an emphasis on dental implications.
authors.affiliation: Associate Professor, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences Bengaluru, Karnataka, India, e-mail: sbpatil1612@gmail.com.
authors.forename: Shankargouda
authors.initials: S
authors.lastname: Patil
authors.affiliation: Professor and Head, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences Bengaluru, Karnataka, India.
authors.forename: Roopa S
authors.initials: RS
authors.lastname: Rao
authors.affiliation: Postgraduate Student, Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, MS Ramaiah University of Applied Sciences Bengaluru, Karnataka, India.
authors.forename: Barnali
authors.initials: B
authors.lastname: Majumdar
mesh_terms: D025063:Chromosome Disorders / Q000235:genetics; D019465:Craniofacial Abnormalities / Q000235:genetics*; D003394:Craniofacial Dysostosis / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006801:Humans; D009056:Mouth Abnormalities / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D014071:Tooth Abnormalities / Q000235:genetics