title: Association between serum free thyroxine (FT4) and uric acid levels in populations without overt thyroid dysfunction.
abstract: In this study, we investigated the relationship between thyroid function and serum uric acid (UA) levels in subjects without overt thyroid dysfunction. A total of 6,085 patients were included in this cross-sectional study. Free thyroxine (FT4) levels were positively and linearly associated with serum UA levels (p<0.001), even after adjusting for age, thyroid-stimulating hormone, renal function, and other metabolic components (B 37.13; 95%CI 25.99-48.28; p<0.001). Furthermore, quartile analysis indicated that the prevalence of hyperuricemia was significantly elevated with increasing FT4 levels (quartile II: OR 1.232, 95%CI 1.022-1.486, p=0.029; quartile III: OR 1.234, 95%CI 1.025-1.486, p=0.026; quartile IV: OR 1.409, 95%CI 1.168-1.701, p<0.001). In summary, FT4 is linearly associated with serum UA levels in subjects lacking clinical thyroid dysfunction, and the prevalence of hyperuricemia is elevated with increasing FT4 levels.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing.
authors.forename: Yicong
authors.initials: Y
authors.lastname: Ye
authors.affiliation: Department of Physical Examination Center, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Gai
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Xie
authors.affiliation: Department of Physical Examination Center, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Jiao
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing Zhangebmg@gmail.com.
authors.forename: Shuyang
authors.initials: S
authors.lastname: Zhang
mesh_terms: D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000503:physiopathology; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000503:physiopathology*; D013974:Thyroxine / Q000097:blood*; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D013974:Thyroxine
keywords: Free thyroxine; hyperuricemia; thyroid-stimulating hormone; uric acid