title: Review: Annexin-A5 and cell membrane repair.
abstract: Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca(2+)-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dimensional (2D) arrays on membrane surfaces. We have previously reported that AnxA5 plays a central role in the machinery of membrane repair by enabling rapid resealing of plasma membrane disruption in murine perivascular cells. AnxA5 promotes membrane repair via the formation of a protective 2D bandage at membrane damaged site. Here, we review current knowledge on cell membrane repair and present recent findings on the role of AnxA5 in membrane resealing of human trophoblasts.
authors.affiliation: Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France. Electronic address: a.bouter@cbmn.u-bordeaux.fr.
authors.forename: A
authors.initials: A
authors.lastname: Bouter
authors.affiliation: Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France.
authors.forename: R
authors.initials: R
authors.lastname: Carmeille
authors.affiliation: Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France.
authors.forename: C
authors.initials: C
authors.lastname: Gounou
authors.affiliation: Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France.
authors.forename: F
authors.initials: F
authors.lastname: Bouvet
authors.affiliation: Fondation PremUP, Paris F-75006, France; INSERM, U1139, Paris F-75006, France; Université Paris Descartes, UMR-S1139 Sorbonne Paris Cité, Paris F-75006, France.
authors.forename: S A
authors.initials: SA
authors.lastname: Degrelle
authors.affiliation: Fondation PremUP, Paris F-75006, France; INSERM, U1139, Paris F-75006, France; Université Paris Descartes, UMR-S1139 Sorbonne Paris Cité, Paris F-75006, France.
authors.forename: D
authors.initials: D
authors.lastname: Evain-Brion
authors.affiliation: Molecular Imaging and NanoBioTechnology, UMR-5248-CBMN CNRS-University of Bordeaux-IPB, Allée Geoffroy Saint-Hilaire, F-33600 Pessac, France.
authors.forename: A R
authors.initials: AR
authors.lastname: Brisson
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D005260:Female; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology; D051379:Mice; D011247:Pregnancy; D012038:Regeneration / Q000502:physiology*; D014327:Trophoblasts / Q000502:physiology / Q000648:ultrastructure
chemical_list: D017304:Annexin A5; D008563:Membrane Lipids
keywords: Annexin-A5; Membrane repair; Placenta; Trophoblast