title: Expression of DJ-1 and mTOR in eutopic and ectopic endometria of patients with endometriosis and adenomyosis.
abstract: OBJECTIVE
  Endometrial cells may aberrantly express molecules involved in invasion and migration, leading to endometriosis. The aim of this study was to investigate the expression of DJ-1 and phosphorylated mammalian target of rapamycin (p-mTOR) in ectopic and eutopic endometria of endometriosis and adenomyosis.
  
  
  METHODS
  Endometrial specimens were obtained from healthy non-menopausal women (n = 17) or patients with ovarian endometriotic cysts (n = 48) or adenomyosis (n = 30) during January 2011 to June 2012. The expressions of DJ-1 and p-mTOR were evaluated by immunohistochemistry and western blotting methods.
  
  
  RESULTS
  The expressions of DJ-1 and p-mTOR were significantly higher in the ectopic endometria than those in the eutopic endometria of endometriosis and adenomyosis patients or normal endometria (FDR < 0.05). DJ-1 expression was positively correlated with the p-mTOR expression no matter at endometriosis (r = 0.736, FDR < 0.001) or adenomyosis (r = 0.809, FDR < 0.001).
  
  
  CONCLUSIONS
  DJ-1 protein may be involved in endometrial cells proliferation, migration and angiogenesis by modulating the PI3K/Akt/p-mTOR signaling pathway, which provides an underlying theoretical target for endometriosis and adenomyosis.
authors.affiliation: Medical Department of Graduate School of Nanchang University, Nanchang, Jiangxi, China.
authors.forename: Jiubai
authors.initials: J
authors.lastname: Guo
authors.forename: Jumei
authors.initials: J
authors.lastname: Gao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yu
authors.forename: Hailian
authors.initials: H
authors.lastname: Luo
authors.forename: Xiasi
authors.initials: X
authors.lastname: Xiong
authors.forename: Ouping
authors.initials: O
authors.lastname: Huang
mesh_terms: D062788:Adenomyosis / Q000378:metabolism*; D000328:Adult; D015153:Blotting, Western; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D015513:Oncogene Proteins / Q000378:metabolism*; D000071617:Protein Deglycase DJ-1; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1