title: Intestinal neuronal dysplasia-like histopathology in infancy.
abstract: The present patient was delivered at a gestational age of 27 weeks. She had abdominal bloating with symptoms of respiratory distress. We suspected Hirschsprung disease (HD) or small intestinal stricture, but examinations were not definitive. Exploratory laparotomy was performed at 97 days of age. Intraoperative findings showed no evidence of small intestinal stricture or changes in intestinal caliber. A transanal drainage tube was inserted, and decompression therapy and intestinal lavage were started. Rectal mucosal biopsy was performed at 184 days of age, and HE and acetylcholinesterase staining showed intestinal neuronal dysplasia (IND)-like pathological findings. At 15 months, giant ganglia were no longer present on follow-up rectal mucosal biopsy, and the pathological diagnosis was normoganglionosis. It should be recognized that while the enteric nervous system is developing, IND-like pathological findings may be seen as a pathological condition during the maturation process.
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hirayama
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Iinuma
authors.affiliation: Department of Neonatology, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Fujito
authors.initials: F
authors.lastname: Numano
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Masui
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Hisataka
authors.initials: H
authors.lastname: Iida
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Komatsuzaki
authors.affiliation: Department of Neonatology, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Yosihisa
authors.initials: Y
authors.lastname: Nagayama
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Naito
authors.affiliation: Department of Pediatric Surgery, Perinatal Medical Center, Niigata City General Hospital, Niigata, Japan.
authors.forename: Koju
authors.initials: K
authors.lastname: Nitta
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D004065:Digestive System Abnormalities / Q000175:diagnosis*; D017615:Enteric Nervous System / Q000473:pathology*; D005260:Female; D006627:Hirschsprung Disease / Q000473:pathology*; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*
keywords: Hirschsprung disease; allied disorder; constipation; gastrointestinal dysfunction; intestinal neuronal dysplasia