title: Effect of simultaneous administration of oral polio vaccine on local reaction of BCG vaccine in term infants.
abstract: OBJECTIVE
  To study local reaction and to ascertain timing of scar formation in infants after BCG vaccination at birth, with and without simultaneous administration of trivalent OPV.
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  Teaching hospital in Lucknow, India.
  
  
  METHODS
  152 term neonates born in the hospital and given BCG and OPV 0-dose simultaneously before discharge, within 7 days of birth (Group I) , and 122 infants born at home or in private health facility, not given OPV-0 dose, coming for vaccination within 7 days of age (Group 2).
  Follow up done at 6 week, 10 week, 14 week and 9 months. Local reaction was recorded at the site of BCG vaccination.
  
  
  RESULTS
  Scar formed in ≤14 wks in 51.3% and 89.3% babies in Group 1 and Group 2, respectively following BCG vaccination (P<0.001). At 9 months, scar developed in 93.9% infants in Group I and 94.3% babies in Group II. Abortive reaction and non-reactors were similar in both groups (P>0.05).
  
  
  CONCLUSIONS
  Simultaneous administration of BCG vaccine with trivalent OPV to term infants in early neonatal period prolongs the time of scar formation but sequence of local reaction is not affected.
authors.affiliation: Department of Pediatrics, Era's Lucknow Medical College, Lucknow, UP, India. Correspondence to: Dr MMA Faridi, E-9 GTB Hospital, Delhi 110 095, India. drmmafaridi@gmail.com.
authors.forename: M M A
authors.initials: MM
authors.lastname: Faridi
authors.forename: Shitanshu
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects; D002921:Cicatrix; D005260:Female; D006801:Humans; D007194:India; D007231:Infant, Newborn; D008297:Male; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D014611:Vaccination
chemical_list: D001500:BCG Vaccine; D011055:Poliovirus Vaccine, Oral