title: Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients.
abstract: Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay. The expressions of omentin-1 were measured by immunohistochemistry in 3 psoriasis affected skins and 3 normal skins. The rs2274907 variant was typed using a SNaPshot assay in 354 cases and 214 controls. We found significantly lower serum levels of omentin-1 in psoriasis patients compared with healthy controls (p < 0.001) with an inverse correlation with the Psoriasis Area and Severity Index (p < 0.01). The comparison of genotype and allele distribution revealed no significant difference in genotype frequency between psoriasis patients and controls. Therefore, omentin-1 may have a role in the pathogenesis of psoriasis and might be a potential biological marker for psoriasis severity.
authors.affiliation: Department of Dermatology and Venerology, Anhui Provincial Hospital, Hefei, Anhui, China, zcwill@163.com.
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: K J
authors.initials: KJ
authors.lastname: Zhu
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: G X
authors.initials: GX
authors.lastname: Xu
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: F X
authors.initials: FX
authors.lastname: Jiang
authors.forename: H F
authors.initials: HF
authors.lastname: Zheng
authors.forename: C
authors.initials: C
authors.lastname: Quan
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000328:Adult; D001706:Biopsy; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood* / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D060005:Genotyping Techniques; D006801:Humans; D037102:Lectins / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000097:blood* / Q000235:genetics; D012867:Skin / Q000378:metabolism
chemical_list: D054392:Adipokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins