title: Sinonasal melanoma arising from conjunctival primary acquired melanosis.
abstract: A 66-year-old woman was treated with excision and cryotherapy for recurrent primary acquired melanosis (PAM) with atypia of the right conjunctiva. Four years later, she developed a melanoma of the ipsilateral inferior turbinate and nasolacrimal duct. She was treated with right medial maxillectomy and postoperative radiation therapy. This is the first reported case of conjunctival PAM resulting in delayed progression to melanoma in the nasolacrimal duct and sinonasal cavity.
authors.affiliation: University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Shehata
authors.affiliation: Department of Ophthalmology, MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Gombos
authors.affiliation: Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, USA.
authors.forename: John
authors.initials: J
authors.lastname: Bishop
authors.affiliation: Department of Head and Neck Surgery, MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Mark Edwin
authors.initials: ME
authors.lastname: Zafereo
mesh_terms: D000368:Aged; D001706:Biopsy; D003230:Conjunctival Neoplasms / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis*; D008548:Melanosis / Q000150:complications*; D009669:Nose Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed