title: Mn-salen catalysed benzylic C-H activation for the synthesis of aryl [(18)F]CF3-containing PET probes.
abstract: The development of a Mn-salen complex catalysed oxidative benzylic fluorination of non-activated C-H bonds using [(18)F]fluoride is described for installation of [(18)F]CHRF, [(18)F]CR2F and particularly [(18)F]CF3 containing groups in the presence of other functional groups.
authors.affiliation: Comprehensive Cancer Imaging Centre, Department of Surgery and Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK. l.carroll@imperial.ac.uk.
authors.forename: L
authors.initials: L
authors.lastname: Carroll
authors.forename: H L
authors.initials: HL
authors.lastname: Evans
authors.forename: A C
authors.initials: AC
authors.lastname: Spivey
authors.forename: E O
authors.initials: EO
authors.lastname: Aboagye
mesh_terms: D002384:Catalysis; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes; D009281:Naphthalenes / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D049268:Positron-Emission Tomography
chemical_list: D005456:Fluorescent Dyes; D005462:Fluorine Radioisotopes; C542902:Mn-salen; D009281:Naphthalenes; D009942:Organometallic Compounds