title: Bioactive Metabolites from the Fruits of Psoralea corylifolia.
abstract: Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia. On the basis of combined spectroscopic and chemical analysis, the new compounds were determined to be six flavonoids (1-6) and a meroterpenoid (7). The absolute configurations of the natural products obtained, including the previously undetermined 16 and 17, were assigned by several methods, such as NOE spectroscopy, optical rotation, and CD spectroscopy. Several of these compounds exhibited moderate inhibitory activity toward Staphylococcus mutans-derived SrtA (2, 6, and 16) and significant stimulation of SIRT1 activity (2, 3, and 15).
authors.affiliation: †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Won
authors.affiliation: †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Inn-Hye
authors.initials: IH
authors.lastname: Song
authors.affiliation: ‡College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Kuk-Hwa
authors.initials: KH
authors.lastname: Kim
authors.forename: Woo-Young
authors.initials: WY
authors.lastname: Yang
authors.affiliation: †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.affiliation: †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: ‡College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Won-Keun
authors.initials: WK
authors.lastname: Oh
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: †Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D019881:Aminoacyltransferases / Q000187:drug effects; D001426:Bacterial Proteins / Q000187:drug effects; D003546:Cysteine Endopeptidases / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029907:Psoralea / Q000737:chemistry*; D056910:Republic of Korea; D013210:Staphylococcus / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D001426:Bacterial Proteins; D005419:Flavonoids; D013729:Terpenes; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases