title: Fractional flow reserve modeled from resting coronary CT angiography: state of the science.
abstract: OBJECTIVE. The purpose of this article is to discuss recent technologic innovations that enable noninvasive calculation of fractional flow reserve (FFR) from CT. CONCLUSION. FFR CT is superior to coronary CT angiography (CTA) stenosis for the diagnosis of ischemia-causing lesions. FFR CT improves the diagnostic accuracy mostly by reducing the false-positive rates incorrectly classified by CTA stenosis alone. Furthermore, in patients in whom CT shows an intermediate stenosis-wherein the results of CT alone are the most clinically ambiguous for ischemia diagnosis-FFR CT shows significantly higher diagnostic performance than CT alone.
authors.affiliation: 1 Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, 1081 Burrard St, University of British Columbia, Vancouver, BC V6N 2N7 Canada.
authors.forename: Bruce
authors.initials: B
authors.lastname: Precious
authors.forename: Philipp
authors.initials: P
authors.lastname: Blanke
authors.forename: Bjarne L
authors.initials: BL
authors.lastname: Nørgaard
authors.forename: James K
authors.initials: JK
authors.lastname: Min
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
mesh_terms: D017023:Coronary Angiography / Q000379:methods; D053805:Fractional Flow Reserve, Myocardial; D006801:Humans; D008955:Models, Cardiovascular; D014057:Tomography, X-Ray Computed
keywords: FFR CT fractional flow reserve (FFR); computational fluid dynamics; coronary CT angiography (CTA)