title: [The possibilities and perspectives of using scaffold technology for bone regeneration].
abstract: The article deals with the one of the topical problem of tissue engineering--the design and implementation of biomaterials that could replace and repair bone defects. This review presents the recent studies of the potential of scaffold technology in bone tissue regeneration. This article contains information about the basic parameters and properties of modern scaffold systems. The results of experimental in vitro and in vivo studies on the use of matrices made of various materials are shown. Advantages and disadvantages of various materials used for the production of scaffolds are discussed. Attention is paid to the advantages combinations of different materials to achieve the desired structural and functional properties. Particular attention is paid to technologies and systems of targeted delivery and controlled release of factors that stimulate bone tissue regeneration. Different strategies for modulating tissue reactions and immune responses that take place during scaffold implantation are presented.
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanov
authors.forename: I A
authors.initials: IA
authors.lastname: Norkin
authors.forename: D M
authors.initials: DM
authors.lastname: Puchin'ian
mesh_terms: D000818:Animals; D000077214:Becaplermin; D001672:Biocompatible Materials / Q000737:chemistry; D055396:Bone Morphogenetic Protein 2 / Q000378:metabolism / Q000494:pharmacology; D055419:Bone Morphogenetic Protein 7 / Q000378:metabolism / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D048271:Chitosan / Q000737:chemistry; D003094:Collagen / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000378:metabolism / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D011140:Polyurethanes / Q000737:chemistry; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism / Q000494:pharmacology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism / Q000494:pharmacology
chemical_list: C525718:BMP2 protein, human; D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D020574:Proto-Oncogene Proteins c-sis; D053773:Transforming Growth Factor beta1; D000077214:Becaplermin; D005346:Fibroblast Growth Factors; D003094:Collagen; D048271:Chitosan