title: The role of fundus autofluorescence imaging in the study of the course of posterior uveitis disorders.
abstract: BACKGROUND
  To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders.
  
  
  METHODS
  Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis. Also, some cases with undefined retinochoroiditis were included. FAF and ICGA were performed and correlated at baseline and during follow-up after treatment.
  
  
  RESULTS
  In ICGA, early hypofluorescence was found to be the hallmark of acute choroidal inflammation, resolving in later stages and remaining in the late phase in areas with retinal pigment epithelium (RPE) damage. Poorly defined hyperautofluorescent areas correlated with acute choroidal lesions. Hypoautofluorescent delineation suggested the initiation of RPE healing processes, correlating well with the late phase of ICGA and delineating the RPE damage. Early hyperautofluorescence with late hypofluorescence in ICGA indicated the presence of primary RPE involvement.
  
  
  CONCLUSIONS
  FAF contributes to the interpretation of RPE disease and may be a useful tool for the follow-up of progressive inflammatory disorders. Comparative evaluation of FAF and ICGA allows a characterization of the sequence of inflammatory events and the level of tissue affected.
authors.affiliation: Department of Ophthalmology, Ocular Immunology and Inflammation Service, "G. Gennimatas" General Hospital of Athens, Athens, Greece.
authors.forename: Panagiotis
authors.identifier: 0000-0001-8313-0561
authors.initials: P
authors.lastname: Malamos
authors.affiliation: 1st Department of Ophthalmology, "G. Gennimatas" General Hospital of Athens, University of Athens, 59 Chrysnathemon Street, Psychiko, 15452 Athens, Greece.
authors.forename: Panos
authors.initials: P
authors.lastname: Masaoutis
authors.affiliation: 1st Department of Ophthalmology, "G. Gennimatas" General Hospital of Athens, University of Athens, 59 Chrysnathemon Street, Psychiko, 15452 Athens, Greece.
authors.forename: Ilias
authors.identifier: 0000-0002-6171-5865
authors.initials: I
authors.lastname: Georgalas
authors.affiliation: Institute of Ocular Inflammation and Pathology of the Eye, Athens, Greece.
authors.forename: Stelios
authors.initials: S
authors.lastname: Maselos
authors.affiliation: 1st Department of Ophthalmology, "G. Gennimatas" General Hospital of Athens, University of Athens, 59 Chrysnathemon Street, Psychiko, 15452 Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Andrianopoulos
authors.affiliation: 1st Department of Ophthalmology, "G. Gennimatas" General Hospital of Athens, University of Athens, 59 Chrysnathemon Street, Psychiko, 15452 Athens, Greece.
authors.forename: Chryssanthi
authors.initials: C
authors.lastname: Koutsandrea
authors.affiliation: Institute of Ocular Inflammation and Pathology of the Eye, Athens, Greece.
authors.forename: Nikos N
authors.initials: NN
authors.lastname: Markomichelakis
mesh_terms: D000792:Angiography / Q000379:methods; D002829:Choroid / Q000473:pathology; D002833:Choroiditis / Q000175:diagnosis / Q000473:pathology; D004396:Coloring Agents; D005451:Fluorescein Angiography / Q000379:methods; D006801:Humans; D007208:Indocyanine Green; D007249:Inflammation / Q000175:diagnosis / Q000473:pathology; D061848:Optical Imaging / Q000379:methods; D055213:Retinal Pigment Epithelium / Q000473:pathology; D015866:Uveitis, Posterior / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green