title: The association of LOXL1 polymorphisms with exfoliation syndrome/glaucoma: Meta-analysis.
abstract: OBJECTIVE
  To investigate the association of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG).
  
  
  METHODS
  Published manuscripts from PubMed and EMBASE were identified until May 2014. Summary odds ratios (ORs) and 95% confidence intervals (CIs) for LOXL1 (rs1048661, rs2165241 and rs3825942) polymorphisms and the risk of XFS/XFG were estimated using random- or fixed- effect model.
  
  
  RESULTS
  The three LOXL1 polymorphisms (rs1048661, rs3825942, and rs2165241) were associated with an increased risk for XFS/XFG among Caucasians, with OR 2.19(1.96-2.45), 8.8 (6.05-12.79) and 3.41 (3.11-3.73), respectively. On the contrast, the rs1048661 and rs2165241, but not rs3825942 polymorphism, have a potential protective effect on XFS/XFG in Asians, with OR 0.06 (0.02-0.18), 0.15 (0.09-0.25), respectively.
  
  
  CONCLUSIONS
  There is strong evidence that LOXL1 polymorphisms are associated with XFS/XFG risk. The strength of risk might be ethnicity-dependent.
authors.affiliation: Department of Ophthalmology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Ji
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Qi
authors.affiliation: Department of Ophthalmology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, Anhui Province, China.
authors.forename: Yue-Chun
authors.initials: YC
authors.lastname: Wen
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Cell Biology, the Cell Biology Institute of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Guo
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Guo-Cheng
authors.initials: GC
authors.lastname: Yu
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Jing-Xiang
authors.initials: JX
authors.lastname: Zhong
keywords: Meta-analysis; exfoliation syndrome; glaucoma; lysyl oxidase-like 1; polymorphism