title: Effect of low-dose (single-dose) magnesium sulfate on postoperative analgesia in hysterectomy patients receiving balanced general anesthesia.
abstract: Background and Aim. Aparallel, randomized, double blinded, placebo-controlled trial study was designed to assess the efficacy of single low dose of intravenous magnesium sulfate on post-total abdominal hysterectomy (TAH) pain relief under balanced general anesthesia. Subject and Methods. Forty women undergoing TAH surgery were assigned to two magnesium sulfate (N = 20) and normal saline (N = 20) groups randomly. The magnesium group received magnesium sulfate 50 mg·kg(-1) in 100 mL of normal saline solution i.v as single-dose, just 15 minutes before induction of anesthesia whereas patients in control group received 100 mL of 0.9% sodium chloride solution at the same time. The same balanced general anesthesia was induced for two groups. Pethidine consumption was recorded over 24 hours precisely as postoperative analgesic. Pain score was evaluated with Numeric Rating Scale (NRS) at 0, 6, 12, and 24 hours after the surgeries. Results. Postoperative pain score was lower in magnesium group at 6, 12, and 24 hours after the operations significantly (P < 0.05). Pethidine requirement was significantly lower in magnesium group throughout 24 hours after the surgeries (P = 0.0001). Conclusion. Single dose of magnesium sulfate during balanced general anesthesia could be considered as effective and safe method to reduce postoperative pain and opioid consumption after TAH.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Tehran University of Medical Science, Tehran 19986 35696, Iran.
authors.forename: Arman
authors.initials: A
authors.lastname: Taheri
authors.affiliation: Department of Anesthesiology, Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan 14455 41656, Iran.
authors.forename: Katayoun
authors.identifier: 0000-0002-5121-7774
authors.initials: K
authors.lastname: Haryalchi
authors.affiliation: Department of Gynecology, Reproductive Health Research Center, Guilan University of Medical Sciences, Guilan 14455 41656, Iran.
authors.forename: Mandana
authors.initials: M
authors.lastname: Mansour Ghanaie
authors.affiliation: Department of Internal Medicine, Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin 14816 46341, Iran.
authors.forename: Neda
authors.identifier: 0000-0002-5911-2563
authors.initials: N
authors.lastname: Habibi Arejan