title: A turn-on coordination nanoparticle-based fluorescent probe for phosphate in human serum.
abstract: Coordination nanoparticles (CNPs) are becoming attractive platforms for chemical sensing applications because their unique adjustable properties offer the opportunity to design various luminescent nanoprobes. Here, we present a CNP-based fluorescent nanoprobe, in which fluorophores (rhodamine B, RB) and quenchers (methylene blue, MB) were spontaneously enfolded by coordination networks self-assembled of adenine, biphenyl-4,4'-dicarboxylic acid (BDA) and zinc ions. The aggregation of fluorophores and quenchers in CNPs resulted in a quenched state fluorescence of RB. RB and MB could be released from CNPs in the presence of phosphate, which triggered the fluorescence of RB. On the basis of recognition-driven disassembly principle, a novel turn-on fluorescent probe for the determination of PO4(3-) with a wide response range (0.5-50 μM) has been successfully applied in the detection of phosphate in human serum samples. This work not only develops a probe for phosphate but also provides a general strategy for designing nanoprobes or nanocarriers towards various targets by altering organic linkers or metal ions.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, China. zhengliyan@ynu.edu.cn qecao@ynu.edu.cn.
authors.forename: Na
authors.initials: N
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Lu
authors.forename: Longchun
authors.initials: L
authors.lastname: Bian
authors.forename: Liyan
authors.initials: L
authors.lastname: Zheng
authors.forename: Qiue
authors.initials: Q
authors.lastname: Cao
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D000225:Adenine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008751:Methylene Blue / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010710:Phosphates / Q000097:blood* / Q000737:chemistry; D012235:Rhodamines / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D010710:Phosphates; D012235:Rhodamines; D015032:Zinc; D000225:Adenine; C029773:rhodamine B; D008751:Methylene Blue