title: Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan.
abstract: We developed a highly stable lipid-polymer nanoarchitectural platform for effective combination therapy of doxorubicin and irinotecan in the polyelectrolyte complex nanoparticle core, followed by incorporation of the whole assembly into a lecithin bilayer. It shows great potential for the treatment of a broad range of cancers.
authors.affiliation: College of Pharmacy, Yeungnam University, 214-1, Dae-dong, Gyeongsan, 712-749, South Korea. csyong@ynu.ac.kr jongohkim@yu.ac.kr.
authors.forename: T
authors.initials: T
authors.lastname: Ramasamy
authors.forename: H B
authors.initials: HB
authors.lastname: Ruttala
authors.forename: J Y
authors.initials: JY
authors.lastname: Choi
authors.forename: T H
authors.initials: TH
authors.lastname: Tran
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: S K
authors.initials: SK
authors.lastname: Ku
authors.forename: H G
authors.initials: HG
authors.lastname: Choi
authors.forename: C S
authors.initials: CS
authors.lastname: Yong
authors.forename: J O
authors.initials: JO
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D006367:HeLa Cells; D006801:Humans; D000077146:Irinotecan; D054709:Lecithins / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011108:Polymers / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D054709:Lecithins; D008051:Lipid Bilayers; D011108:Polymers; D000077146:Irinotecan; D004317:Doxorubicin; D002166:Camptothecin