title: Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats.
abstract: BACKGROUND
  This study was designed to provide information about the antipyretic and anti-inflammatory effects of Corchorus olitorius root.
  
  
  METHODS
  Thirty male Wistar rats were divided into six groups of five animals each; the control and reference groups were administered normal saline (10 mL/kg) and indomethacin (5 mg/kg), respectively, whereas the remaining four groups were administered aqueous extract of C. olitorius at doses of 25, 50, 100, or 200 mg/kg, respectively. Pyrexia was induced by injecting 10 mL/kg of 20% (w/v) brewer's yeast suspension into the dorsum of rats, whereas inflammation was induced through an injection of 0.1% carrageenan into the right hind paw of each rat and through a subcutaneous implantation of a 30-g sterilized cotton pellet into the groin of each rat.
  
  
  RESULTS
  The results showed that C. olitorius root extract (p<0.05) decreased the elevated temperature after brewer's yeast injection compared with the 17 h (pre-drug) temperature. In the inflammatory tests, the paw sizes and granuloma weights in the test groups were significantly (p<0.05) decreased compared with the control group.
  
  
  CONCLUSIONS
  Corchorus olitorius root is another good source of phytomedicine that can be used effectively to treat inflammation and pyrexia that accompany some diseases.
authors.forename: Bamidele V
authors.initials: BV
authors.lastname: Owoyele
authors.forename: Aboyeji L
authors.initials: AL
authors.lastname: Oyewole
authors.forename: Modupe L
authors.initials: ML
authors.lastname: Alimi
authors.forename: Shukurat A
authors.initials: SA
authors.lastname: Sanni
authors.forename: Sabitiu A
authors.initials: SA
authors.lastname: Oyeleke
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D032381:Corchorus; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts; D007213:Indomethacin