title: [Ocular toxoplasmosis - seeking a strategy for treatment].
abstract: OBJECTIVE
  To compare the effectiveness of treatment for ocular toxoplasmosis with pyrimethamine + clindamycin (or sulfadiazine) + a corticoid (Group 1), or azithromycin or a combination of azithromycin with a corticoid or a corticoid alone (Group 2). To determine the relapse rate depending on the treatment approach.
  
  
  METHODS
  A total of 25 patients treated for ocular toxoplasmosis over the last five years (2008-2013) were analyzed. Group 1 comprised 16 patients (3 were excluded) and Group 2 consisted of 6 patients.
  
  
  RESULTS
  Visual improvement was more rapid in Group 1 (day 10.7) than in Group 2 (significant improvement on day 29.6). There were 5 cases of relapse in Group 1; in 13 cases, no relapse was noted; all patients in Group 2 relapsed (a total of 13 relapses). Twenty-three patients were positive for specific IgG antibodies.
  
  
  CONCLUSIONS
  According to our experiences, pyrimethamine + clindamycin (or sulfadiazine) + a corticoid should be the treatment of choice in patients with ocular toxoplasmosis.
authors.affiliation: Department of Infectious Diseases, University Hospital and Faculty of Medicine Hradec Králové, Charles University, Czech Republic, e-mail: PPrasil@seznam.cz.
authors.forename: Petr
authors.initials: P
authors.lastname: Prášil
authors.forename: Stanislav
authors.initials: S
authors.lastname: Plíšek
authors.forename: Pavel
authors.initials: P
authors.lastname: Boštík
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D014126:Toxoplasmosis, Ocular / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents