title: Lipidomics applications for disease biomarker discovery in mammal models.
abstract: Lipidomics is a lipid-targeted metabolomics approach focusing on comprehensive analysis of all lipids with which they interact in biology systems. Recent technological advances in MS and chromatography have greatly enhanced the developments and applications of metabolic profiling of diverse lipids in complex biological samples. Lipidomics will not only provide insights into the specific functions of lipid species in health and disease, but will also identify potential biomarkers for establishing preventive or therapeutic programs for human disease. In this review, recent applications of lipidomics to understand animal models of disease such as metabolic syndromes, neurodegenerative diseases, cancer and infectious diseases are considered. We also discuss the lipidomics for the future perspectives and their potential problems.
authors.affiliation: Key Laboratory of Resource Biology & Biotechnology in Western China, Ministry of Education, The College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
authors.forename: Ying-Yong
authors.initials: YY
authors.lastname: Zhao
authors.forename: Xian-Long
authors.initials: XL
authors.lastname: Cheng
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D003141:Communicable Diseases / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008322:Mammals / Q000378:metabolism*; D008659:Metabolic Diseases / Q000175:diagnosis / Q000378:metabolism; D055432:Metabolomics / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008055:Lipids
keywords: animal models; disease biomarkers; lipid biomarkers; lipid profiling; lipidome; lipidomics; liquid chromatography; mass spectrometry; metabolomics; system biology