title: Distribution of sulfamonomethoxine and trimethoprim in egg yolk and white.
abstract: The distribution of sulfamonomethoxine (SMM) and trimethoprim (TMP) in egg yolk and white was measured during and after administration of a SMM/TMP combination in laying hens in doses of 8 g l(-)(1) and 12 g l(-)(1) in drinking water for 7 days. The SMM concentration reached maximal levels on day 2 of the post-treatment period for both doses (μg kg(-)(1)): 5920 and 9453 in yolk; 4831 and 6050 in white, in doses 1 and 2, respectively. Significant differences in the SMM and TMP concentrations between yolk and white in post treatment period were found. SMM dropped below the LOD (1.9 μg kg(-1)) in yolk after day 16 and 19 for doses 1 and 2. TMP reached maximal levels on day 3 after drug administration for doses 1 and 2 (μg kg(-)(1)): 6521 and 7329 in yolk, 1370 and 1539 in white. TMP residues were measured above LOD (0.3 μg kg(-)(1)) in yolk for both doses on day 37 post-treatment.
authors.affiliation: Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia. Electronic address: bilandzic@veinst.hr.
authors.forename: Nina
authors.initials: N
authors.lastname: Bilandžić
authors.affiliation: Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
authors.forename: Đurđica
authors.initials: Đ
authors.lastname: Božić
authors.affiliation: Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
authors.forename: Božica Solomun
authors.initials: BS
authors.lastname: Kolanović
authors.affiliation: Department of Veterinary Public Health, Laboratory for Residue Control, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Varenina
authors.affiliation: Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia.
authors.forename: Luka
authors.initials: L
authors.lastname: Cvetnić
authors.affiliation: General Department, Croatian Veterinary Institute, Savska cesta 143, HR-10000 Zagreb, Croatia.
authors.forename: Željko
authors.initials: Ž
authors.lastname: Cvetnić
mesh_terms: D000818:Animals; D004350:Drug Residues / Q000032:analysis; D004530:Egg Yolk / Q000737:chemistry*; D004531:Eggs / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D013422:Sulfamonomethoxine / Q000032:analysis / Q000737:chemistry*; D014295:Trimethoprim / Q000032:analysis / Q000737:chemistry*
chemical_list: D014295:Trimethoprim; D013422:Sulfamonomethoxine
keywords: Egg; Elimination; LC–MS/MS; Laying hens; Sulfamonomethoxine; Trimethoprim; White; Yolk