title: Enzyme transformation to modulate the ligand-receptor interactions between small molecules.
abstract: Enzymatic transformation is a fundamental process to control ligand-receptor interactions among proteins for signal transduction in cells. Here we report the first example of enzymatic transformation regulated ligand-receptor interactions of small molecules, in which enzymatic reaction changes the stoichiometry of the ligand-receptor binding from 1 : 1 to 1 : 2. We also show that this unique integration of enzymatic transformation and ligand-receptor interactions of small molecules is able to affect the fate of cells.
authors.affiliation: Department of Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA. bxu@brandeis.edu.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Shi
authors.forename: Xuewen
authors.initials: X
authors.lastname: Du
authors.forename: Dan
authors.initials: D
authors.lastname: Yuan
authors.forename: Richard
authors.initials: R
authors.lastname: Haburcak
authors.forename: Dongdong
authors.initials: D
authors.lastname: Wu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhou
authors.forename: Bing
authors.initials: B
authors.lastname: Xu
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004798:Enzymes; D008024:Ligands