title: HIV-associated non-Hodgkin lymphoma: viral origins and therapeutic options.
abstract: HIV infection is associated with an increased risk of malignancy, especially B-cell lymphoid malignancies. Many of these lymphomas are further driven by concomitant infection with viruses such as Epstein-Barr virus or Human Herpesvirus 8, the latter being implicated in uncommon types of lymphomas seen in the setting of HIV-1 infection. Treatment outcomes have improved due to infusional chemotherapy, high-dose chemotherapy, and effective antiretroviral therapy. Successful functional cure of HIV-1 infection has been demonstrated with the use of allogeneic hematopoietic stem cell transplantation. This result spurred a change in the field of HIV-1 management so that, ultimately, the goals of therapy would shift from not only curing the underlying lymphoma, but also curing the HIV-1 infection. Treatment options will be discussed with an emphasis on hematopoietic cell-based therapy for the underlying HIV infection.
authors.affiliation: Department of Hematology and Hematopoietic Cell Transplantation and.
authors.forename: Amrita
authors.initials: A
authors.lastname: Krishnan
authors.affiliation: Department of Virology, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.
authors.forename: John A
authors.initials: JA
authors.lastname: Zaia
mesh_terms: D004197:Disease Reservoirs / Q000821:virology; D004306:Dose-Response Relationship, Immunologic; D015658:HIV Infections / Q000150:complications* / Q000628:therapy; D015497:HIV-1 / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy* / Q000821:virology*