title: Ropporin gene expression in infertile asthenozoospermic men with varicocele before and after repair.
abstract: OBJECTIVE
  To assess Ropporin gene expression in the sperm of infertile asthenozoospermic men with varicocele (Vx) before and after repair.
  
  
  METHODS
  This study included 24 infertile asthenozoospermic men with Vx. They were subjected to history taking, clinical examination, scrotal color Doppler, and semen analysis with sperm separation. Three months after varicocelectomy, they were subjected to postoperative color Doppler, semen analysis, and sperm semiquantitative Reverse Transcription-Polymerase Chain Reaction assay for Ropporin gene expression levels.
  
  
  RESULTS
  Ropporin gene expression is significantly associated with different types of sperm motility, except for nonprogressive sperm motility. There was significant Ropporin gene overexpression postvaricocelectomy that was correlated with improved sperm count, sperm motility, and abnormal sperm morphology with decreased veins diameters.
  
  
  CONCLUSIONS
  Ropporin gene expression is related to the sperm motility. Its abnormal expression in the sperm of asthenozoospermic men with Vx is associated with impaired sperm motility that is improved after varicocelectomy.
authors.affiliation: Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Adam International Hospital, Giza, Egypt.
authors.forename: Medhat K
authors.initials: MK
authors.lastname: Amer
authors.affiliation: Department of Dermatology and Andrology, Andrology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Rashad M
authors.initials: RM
authors.lastname: Mostafa
authors.affiliation: Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Amal
authors.initials: A
authors.lastname: Fathy
authors.affiliation: Department of Dermatology and Andrology, Andrology Unit, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
authors.forename: Hany M
authors.initials: HM
authors.lastname: Saad
authors.affiliation: Andrology & Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: taymour1155@link.net.
authors.forename: Taymour
authors.initials: T
authors.lastname: Mostafa
mesh_terms: D000328:Adult; D053627:Asthenozoospermia / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D013076:Sperm Count; D013081:Sperm Motility / Q000235:genetics*; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology; D018615:Ultrasonography, Doppler, Color; D014646:Varicocele / Q000150:complications / Q000000981:diagnostic imaging / Q000601:surgery*; D055815:Young Adult; D020741:rho GTP-Binding Proteins / Q000235:genetics*
chemical_list: D008565:Membrane Proteins; C404565:ROPN1 protein, human; D020741:rho GTP-Binding Proteins