title: Application of the European Test of Olfactory Capabilities in patients with olfactory impairment.
abstract: A central issue in olfaction concerns the characterization of loss of olfactory function: partial (hyposmia) or total (anosmia). This paper reports the application in a clinical setting of the European Test of Olfactory Capabilities (ETOC), combining odor detection and identification. The study included three phases. In phase 1, anosmics, hyposmics and controls were tested with the 16-items version of the ETOC. In phase 2, a short version of the ETOC was developed: patients with and controls without olfactory impairment were tested on a 6-items ETOC. In phase 3, to predict olfactory impairments in new individuals, the 16-items ETOC was administered on samples of young and older adults, and the 6-items version was applied in samples of young, elderly participants and Alzheimer patients. In phase 1, linear discriminant analysis (LDA) of ETOC scores classified patients and controls with 87.5 % accuracy. In phase 2, LDA provided 84 % correct classification. Results of phase 3 revealed: (1) 16-items ETOC: whereas in young adults, 10 % were classified as hyposmic and 90 % as normosmic, in elderly, 1 % were classified as anosmic, 39 % hyposmic and 60 % normosmic; (2) 6-items ETOC: 15 % of the young adults were classified as having olfactory impairment, compared to 28 % in the older group and 83 % in Alzheimer patients. In conclusion, the ETOC enables characterizing the prevalence of olfactory impairment in young subjects and in normal and pathological aging. Whereas the 16-items ETOC is more discriminant, the short ETOC may provide a fast (5-10 min) tool to assess olfaction in clinical settings.
authors.affiliation: CNRS UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, 69000, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Joussain
authors.affiliation: CNRS UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, 69000, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Bessy
authors.affiliation: Hospices Civils de Lyon, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Faure
authors.affiliation: Hospices Civils de Lyon, Lyon, France.
authors.forename: D
authors.initials: D
authors.lastname: Bellil
authors.affiliation: Hôpitaux Universitaires de Genève, Geneva, France.
authors.forename: B N
authors.initials: BN
authors.lastname: Landis
authors.affiliation: Hôpitaux Universitaires de Genève, Geneva, France.
authors.forename: M
authors.initials: M
authors.lastname: Hugentobler
authors.affiliation: Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Tuorila
authors.affiliation: Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Mustonen
authors.affiliation: Department of Otorhinolaryngoly, Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: S I
authors.initials: SI
authors.lastname: Vento
authors.affiliation: Hospices Civils de Lyon, Lyon, France.|Clinical and Research Memory Center of Lyon, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Delphin-Combe
authors.affiliation: CNRS UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, 69000, Lyon, France.|Hospices Civils de Lyon, Lyon, France.|Clinical and Research Memory Center of Lyon, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Krolak-Salmon
authors.affiliation: CNRS UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, 69000, Lyon, France. rouby@univ-lyon1.fr.
authors.forename: C
authors.initials: C
authors.lastname: Rouby
authors.affiliation: CNRS UMR5292, INSERM U1028, Lyon Neuroscience Research Center, University Lyon, 69000, Lyon, France. moustafa.bensafi@cnrs.fr.
authors.forename: M
authors.initials: M
authors.lastname: Bensafi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009812:Odorants / Q000032:analysis*; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D064367:Olfactometry / Q000379:methods*; D015203:Reproducibility of Results; D012903:Smell / Q000502:physiology*
keywords: Alzheimer; Anosmia; ENT; Hyposmia; Olfaction; Screening