title: Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature.
abstract: Intracranial hemorrhage (ICH) is a common complication in acute myeloid leukemia (AML) patients with an incidence rate of 6.3% (1). Bleeding disorders related to disseminated intravascular coagulation (DIC) are common complications in AML cases (2). Recombinant activated Factor VII [rFVIIa (NovoSeven(®))] is approved for the treatment of bleeding complications with FVIII or FIX inhibitors in patients with congenital FVII deficiency. Use of rFVIIa for the treatment of acute hemorrhage in patients without hemophilia has been successful (3, 4). Herein, we describe the successful use of rFVIIa in a patient with acute ICH in the setting of newly diagnosed AML.
authors.affiliation: Department of Leukemia, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Naveen
authors.initials: N
authors.lastname: Pemmaraju
authors.affiliation: Department of Leukemia, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Koji
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Department of Internal Medicine, Louisiana State University , New Orleans, LA , USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Johnson
authors.affiliation: Department of Leukemia, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Naval
authors.initials: N
authors.lastname: Daver
authors.affiliation: Department of Benign Hematology, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Vahid
authors.initials: V
authors.lastname: Afshar-Kharghan
authors.affiliation: Department of Neuro-Oncology, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Merry
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Stem Cell Transplantation, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Sairah
authors.initials: S
authors.lastname: Ahmed
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Rivka R
authors.initials: RR
authors.lastname: Colen
authors.affiliation: Department of Diagnostic Radiology, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Kwon
authors.affiliation: Department of Hematopathology, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Huh
authors.affiliation: Department of Leukemia, MD Anderson Cancer Center , Houston, TX , USA.
authors.forename: Gautam
authors.initials: G
authors.lastname: Borthakur
keywords: acute myeloid leukemia; intracranial hemorrhage; recombinant activated factor VII