title: Event related desynchronisation of mu-wave over right sensorimotor cortex at baseline may predict subsequent response to antipsychotics in Schizophrenia.
abstract: Mirror neuron system (MNS) has been demonstrated to be defective in patients with schizophrenia. This paper report findings from a high resolution (192-channel) EEG study conducted on 15 drug free/naïve consenting schizophrenia patients, in which the specific role of right hemispheric MNS has been explored over 4 weeks of antipsychotic treatment. The authors used mu wave suppression paradigm, and found that baseline right MNS mu suppression correlated negatively with and predicted relative improvement in thought disturbance cluster score of PANSS during first 4 weeks of drug treatment.
authors.affiliation: Department of Psychiatry, Sarojini Naidu Medical College, Agra, Uttar Pradesh 282002, India. Electronic address: sayantanava@gmail.com.
authors.forename: Sayantanava
authors.initials: S
authors.lastname: Mitra
authors.affiliation: Department of Psychiatry and K.S. Mani Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand 834006, India.
authors.forename: S
authors.initials: S
authors.lastname: Haque Nizamie
authors.affiliation: Department of Psychiatry and K.S. Mani Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand 834006, India.
authors.forename: Nishant
authors.initials: N
authors.lastname: Goyal
authors.affiliation: K.S Mani Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand 834006, India.
authors.forename: Sai Krishna
authors.initials: SK
authors.lastname: Tikka
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D058256:Brain Waves / Q000502:physiology*; D016022:Case-Control Studies; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D059167:Mirror Neurons / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D066191:Sensorimotor Cortex / Q000502:physiology*
chemical_list: D014150:Antipsychotic Agents
keywords: Antipsychotic response; Mirror neuron system; Schizophrenia