title: Upper gastrointestinal bleeding in severely burned patients: a case-control study to assess risk factors, causes, and outcome.
abstract: OBJECTIVE
  To determine the risk factors, causes, and outcome of clinically important upper gastrointestinal bleeding that occurs in severely burned patients.
  
  
  METHODS
  The charts of all patients admitted to the burn intensive care unit were analyzed retrospectively over a 4-year period (from January 2006 to December 2009). Cases consisted of burned patients who developed upper gastrointestinal bleeding more than 24 hours after admission to the burn intensive care unit. Controls were a set of patients, in the burn intensive care unit, without upper gastrointestinal bleeding matched with cases for age and gender. Cases and controls were compared with respect to the risk factors of upper gastrointestinal bleeding and outcomes.
  
  
  RESULTS
  During the study period, clinically important upper gastrointestinal bleeding occurred in 20 patients out of all 964 patients. The most common cause of upper gastrointestinal bleeding was duodenal ulcer (11 of 20 cases, 55%). In the multivariate analysis, mechanical ventilation (p = 0.044) and coagulopathy (p = 0.035) were found to be the independent predictors of upper gastrointestinal bleeding in severely burned patients.
  
  
  CONCLUSIONS
  Upper gastrointestinal hemorrhage tends to occur more frequently after having prolonged mechanical ventilation and coagulopathy.
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Koh
authors.forename: Se Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sun Man
authors.initials: SM
authors.lastname: Park
authors.forename: Min Ho
authors.initials: MH
authors.lastname: Choi
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Jang
authors.forename: Sea Hyub
authors.initials: SH
authors.lastname: Kae
authors.forename: Jin
authors.initials: J
authors.lastname: Lee
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Byun
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors