title: Effects of permafrost microorganisms on skin wound reparation.
abstract: Local application of ointment with Bacillus spp. strain MG8 (15,000-20,000 living bacterial cells), isolated from permafrost specimens, on the skin wound of about 60 mm(2) stimulated the reparation processes in experimental mice. A possible mechanism stimulating the regeneration of the damaged tissues under the effect of MG8 could be modulation of the immune system reactivity with more rapid switchover to humoral immunity anti-inflammatory mechanisms aimed at de novo synthesis of protein.
authors.affiliation: Tyumen' Research Center, Siberian Division of the Russian Academy of Sciences, Tyumen, Russia, lkalenova@mail.ru.
authors.forename: L F
authors.initials: LF
authors.lastname: Kalenova
authors.forename: M A
authors.initials: MA
authors.lastname: Novikova
authors.forename: A M
authors.initials: AM
authors.lastname: Subbotin
mesh_terms: D000818:Animals; D001407:Bacillus / Q000276:immunology / Q000502:physiology*; D056724:Immunity, Humoral / Q000276:immunology*; D051379:Mice; D065946:Permafrost / Q000382:microbiology*; D012867:Skin / Q000293:injuries*; D014945:Wound Healing / Q000276:immunology / Q000502:physiology*