title: miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.
abstract: Newly discovered intrinsic regulators, the miRNAs regulate gene expression by binding to the 3'-untranslated regions of the genome. Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers. We found that miRNA-1207-5p (miR‑1207-5p) was markedly downregulated in esophageal carcinoma (EC) tissues, and was correlated with EC differentiation, pathological stage and lymph node metastasis. Rates of apoptosis were increased and cell invasion ability was decreased in EC9706 and EC-1 cells transfected with a miR‑1207-5p mimic. Stomatin-like protein 2 (STOML-2) was predicted to be a potential target of miR‑1207-5p by bioinformatics analysis and this was confirmed by luciferase assay and western blotting. Our study showed that STOML-2 was negatively regulated by miR‑1207-5p. Furthermore, overexpression of STOML-2 abolished the miR‑1207-5p anti-invasion function. Based on these results, we proposed that miR‑1207-5p might act as a potential therapeutic target in the treatment of EC.
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Yang
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Wenqiao
authors.initials: W
authors.lastname: Zang
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Xuan
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Zhongquan
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Tumor Hospital of Linzhou City, Linzhou, Henan 456500, P.R. China.
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Tumor Hospital of Linzhou City, Linzhou, Henan 456500, P.R. China.
authors.forename: Jinwu
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Cui
authors.affiliation: College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, P.R. China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D001798:Blood Proteins / Q000096:biosynthesis* / Q000235:genetics; D015153:Blotting, Western; D045744:Cell Line, Tumor; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014162:Transfection
chemical_list: D001798:Blood Proteins; C575047:MIRN1207 microRNA, human; D008565:Membrane Proteins; D035683:MicroRNAs; C406287:STOML2 protein, human