title: Manipulating directional cell motility using intracellular superparamagnetic nanoparticles.
abstract: This study investigated the ability for magnetic nanoparticles to influence cellular migration in the presence of an external magnetic field. We found that the direction of migrating keratinocytes can be controlled and the migration speed of fibroblasts can be increased with the internalisation of these nanoparticles in the presence of a magnetic field. The possibility of shepherding cells towards a region of interest through the use of internalized nanoparticles is an attractive prospect for cell tracking, cell therapies, and tissue engineering applications.
authors.affiliation: School of Chemistry and Biochemistry, M313, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia. swaminatha.iyer@uwa.edu.au.
authors.forename: Michael
authors.initials: M
authors.lastname: Bradshaw
authors.forename: Tristan D
authors.initials: TD
authors.lastname: Clemons
authors.forename: Diwei
authors.initials: D
authors.lastname: Ho
authors.forename: Lucía
authors.initials: L
authors.lastname: Gutiérrez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Lázaro
authors.forename: Michael J
authors.initials: MJ
authors.lastname: House
authors.forename: Timothy G
authors.initials: TG
authors.lastname: St Pierre
authors.forename: Mark W
authors.initials: MW
authors.lastname: Fear
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Wood
authors.forename: K Swaminathan
authors.initials: KS
authors.lastname: Iyer
mesh_terms: D000818:Animals; D002460:Cell Line; D002465:Cell Movement; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D011109:Polymethacrylic Acids / Q000737:chemistry
chemical_list: D058185:Magnetite Nanoparticles; D011109:Polymethacrylic Acids; C042535:polyglycidyl methacrylate; D052203:Ferrosoferric Oxide