title: [Position paper on the results of Symplicity HTN-3 trial. Grupo de estudio de la hipertensión arterial resistente].
abstract: Renal artery denervation has shown to be an effective treatment for resistant hypertension. Symplicity HTN 1 and 2 trials showed in small and uncontrolled groups, significant systolic blood pressure reductions down to 30 mm Hg. Symplicity HTN-3, a double blind, randomized, placebo controlled clinical trial shaded this initial enthusiasm. Surprisingly, their results showed that renal denervation has a similar effect to placebo. Pre-specified subgroup analysis showed that non-black race individuals, younger than 65 years and with normal renal function, had a statistically significant systolic blood pressure decrease. This manuscript critically appraises the Symplicity HTN-3 trial, proposing possible explanations for the results. Also declares our group position and future actions regarding renal denervation.
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060. Electronic address: drazpiri@yahoo.com.
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Azpiri-López
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Assad-Morell
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Enrique
authors.initials: E
authors.lastname: Ponce de León-Martínez
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Monreal-Puente
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Adrián
authors.initials: A
authors.lastname: Dávila-Bortoni
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Vázquez-Díaz
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Ramón Javier
authors.initials: RJ
authors.lastname: Treviño-Frutos
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Félix
authors.initials: F
authors.lastname: Barrera-Oranday
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Juan Gustavo
authors.initials: JG
authors.lastname: Del Angel-Soto
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: José Guadalupe
authors.initials: JG
authors.lastname: Martínez
authors.affiliation: Hospital Christus Muguerza Alta Especialidad, Hidalgo #2525 Pte, Col. Obispado, Monterrey N.L. México, CO 64060.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Arellano-Torres
mesh_terms: D003714:Denervation; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic
keywords: Ablación por catéter; Catheter ablation; Denervación renal; Estudio Symplicity; Hipertensión arterial; Hipertensión resistente; Renal denervation; Resistant hypertension; Symplicity trial; Systemic arterial hypertension