title: Blockade of oral tolerance to ovalbumin in mice by silver nanoparticles.
abstract: OBJECTIVE
  The authors investigated the effect of silver nanoparticles (Ag NPs) on oral tolerance to dietary antigen ovalbumin (OVA) in mice.
  
  
  METHODS
  Ag NPs were orally administered for 7 days before feeding of OVA and the immunological responses were assayed.
  
  
  RESULTS
  Polyvinyl pyrrolidone-coated Ag NPs (Ag NPs-PVP) were found to block the induction of oral tolerance to OVA. The physicochemical properties of the three kinds of Ag NPs were assessed and silver ions were found to inhibit the induction of oral tolerance, which might be the dominating factor in the blockade of oral tolerance by Ag NPs-PVP.
  
  
  CONCLUSIONS
  Ag NPs with certain physicochemical properties can block oral tolerance to dietary antigen that may induce food allergy in humans.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry & Molecular Engineering, Peking University, Beijing, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Xu
authors.forename: Huan
authors.initials: H
authors.lastname: Tang
authors.forename: Haifang
authors.initials: H
authors.lastname: Wang
authors.forename: Yuanfang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000008:administration & dosage / Q000648:ultrastructure; D010047:Ovalbumin / Q000276:immunology*; D012834:Silver / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012834:Silver; D010047:Ovalbumin
keywords: gastrointestinal tract; oral tolerance; ovalbumin; silver nanoparticles