title: Gangrenous cholecystitis: mortality and risk factors.
abstract: As a serious complication of cholelithiasis, gangrenous cholecystitis presents greater mortality than noncomplicated cholecystitis. The aim of this study was to specify the risk factors on mortality. 107 consecutive patients who underwent surgery due to gangrenous cholecystitis between January 1997 and October 2011 were investigated retrospectively. The study included 60 (56.1%) females and 47 (43.9%) males, with a mean age of 60.7 ± 16.4 (21-88) years. Cardiovascular diseases were the most frequently accompanying medical issues (24.3%). Thirty-six complications (33.6%) developed in 29 patients, and surgical site infection was proven as the most common. Longer delay time prior to hospital admission, low white blood cell count, presence of diabetes mellitus, higher blood levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin, pericholecystic fluid in abdominal ultrasonography, and conversion from laparoscopic surgery to open surgery were identified as risk factors affecting mortality (P < 0.001, P = 0.001, P = 0.044, P = 0.005, P = 0.049, P = 0.009, P = 0.022, P = 0.011, and P = 0.004, respectively). Longer delay time prior to hospital admission and low white blood cell count were determined as independent risk factors affecting mortality.
authors.affiliation: Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
authors.forename: Akın
authors.initials: A
authors.lastname: Önder
authors.forename: Murat
authors.initials: M
authors.lastname: Kapan
authors.forename: Burak Veli
authors.initials: BV
authors.lastname: Ülger
authors.forename: Abdullah
authors.initials: A
authors.lastname: Oğuz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Türkoğlu
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Uslukaya
mesh_terms: D000328:Adult; D000368:Aged; D002764:Cholecystitis / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D002769:Cholelithiasis / Q000150:complications; D005260:Female; D005734:Gangrene / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000150:complications; D013997:Time Factors; D055815:Young Adult
keywords: Cholecystectomy; Gangrenous cholecystitis; mortality