title: Elevated matrix metalloproteinase-8 in saliva and serum in polycystic ovary syndrome and association with gingival inflammation.
abstract: This study aimed to investigate the levels of matrix metalloproteinase-8 (MMP-8) and tissue inhibitors of MMP-1 (TIMP-1) in saliva and serum samples of women with polycystic ovary syndrome (PCOS; n = 80) and matched systemically healthy controls (n = 45), with varying degrees of gingival inflammation. Salivary levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly elevated in women with PCOS, who also exhibited more gingivitis than systemically healthy women. No major changes were observed in salivary TIMP-1 levels with regard to PCOS. Serum levels of MMP-8 and the MMP-8/TIMP-1 ratio were significantly higher in women with PCOS, irrespective of the presence of gingivitis, while there were no differences in TIMP-1 levels. A positive correlation was indicated between probing depth, bleeding on probing, plaque index and salivary or serum MMP-8 levels or MMP-8/TIMP-1 ratio in the case of PCOS, while a negative such correlation was revealed for TIMP-1 in systemically healthy women. Increased levels of MMP-8 in saliva and serum seem to be more pronounced in women with PCOS, and potentiated in the presence of gingival inflammation. Alterations in MMP/TIMP system triggered by local and systemic inflammation may be implicated in the pathogenesis of PCOS, or the deterioration of its clinical presentation.
authors.affiliation: Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Zurich, Switzerland Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Aliye
authors.initials: A
authors.lastname: Akcalı
authors.affiliation: Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Zurich, Switzerland.
authors.forename: Nagihan
authors.initials: N
authors.lastname: Bostanci
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Özgun
authors.initials: Ö
authors.lastname: Özçaka
authors.affiliation: Department of Endocrinology, School of Medicine, Aydın Government Hospital, Aydın, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Öztürk-Ceyhan
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Gümüş
authors.affiliation: University of Helsinki, Institute of Dentistry, Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland.
authors.forename: Taina
authors.initials: T
authors.lastname: Tervahartiala
authors.affiliation: University of Helsinki, Institute of Dentistry, Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland.
authors.forename: Heidi
authors.initials: H
authors.lastname: Husu
authors.affiliation: Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
authors.forename: Nurcan
authors.initials: N
authors.lastname: Buduneli
authors.affiliation: University of Helsinki, Institute of Dentistry, Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Helsinki, Finland Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Timo
authors.initials: T
authors.lastname: Sorsa
authors.affiliation: Institute of Oral Biology, Center of Dental Medicine, University of Zürich, Zurich, Switzerland george.belibasakis@zzm.uzh.ch.
authors.forename: Georgios N
authors.initials: GN
authors.lastname: Belibasakis
mesh_terms: D000367:Age Factors; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005891:Gingivitis / Q000150:complications / Q000276:immunology*; D006801:Humans; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000276:immunology*; D012463:Saliva / Q000378:metabolism; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D019715:Tissue Inhibitor of Metalloproteinase-1; D020784:Matrix Metalloproteinase 8
keywords: Gingivitis; metalloproteinase-8; polycystic ovary syndrome; saliva; serum