title: Malleable mitochondrion of Trypanosoma brucei.
abstract: The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of mitochondrial biology of an early-branching parasitic protist, Trypanosoma brucei, a causative agent of serious human and cattle diseases. We present a comprehensive survey of its mitochondrial pathways including kinetoplast DNA replication and maintenance, gene expression, protein and metabolite import, major metabolic pathways, Fe-S cluster synthesis, ion homeostasis, organellar dynamics, and other processes. As we describe in this chapter, the single mitochondrion of T. brucei is everything but simple and as such rivals mitochondria of multicellular organisms.
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Present address: Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia; Present address: Faculty of Sciences, Charles University, Prague, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Verner
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic; Present address: Institut für Zytobiologie und Zytopathologie, Philipps-Universität Marburg, Germany.
authors.forename: Somsuvro
authors.initials: S
authors.lastname: Basu
authors.affiliation: Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Corinna
authors.initials: C
authors.lastname: Benz
authors.affiliation: Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Sameer
authors.initials: S
authors.lastname: Dixit
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Present address: Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Dobáková
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Drahomíra
authors.initials: D
authors.lastname: Faktorová
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hashimi
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic.
authors.forename: Eva
authors.initials: E
authors.lastname: Horáková
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Zhenqiu
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Paris
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic.
authors.forename: Priscila
authors.initials: P
authors.lastname: Peña-Diaz
authors.affiliation: Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic; Present address: Salk Institute, La Jolla, San Diego, USA.
authors.forename: Lucie
authors.initials: L
authors.lastname: Ridlon
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Týč
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic.
authors.forename: David
authors.initials: D
authors.lastname: Wildridge
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Alena
authors.initials: A
authors.lastname: Zíková
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic; Faculty of Sciences, University of South Bohemia, České Budějovice (Budweis), Czech Republic.
authors.forename: Julius
authors.initials: J
authors.lastname: Lukeš
mesh_terms: D000818:Animals; D001692:Biological Transport; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D024101:Mitochondrial Proteins / Q000378:metabolism; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000378:metabolism*
chemical_list: D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins
keywords: Kinetoplast; Metabolism; Mitochondrial transport; Mitochondrion; RNA import; T. brucei; Trypanosome; kDNA