title: Prognostic significance and clinicopathological features of hypoxic inducible factor-2alpha expression in hepatocellular carcinoma.
abstract: OBJECTIVE
  To assess the association between hypoxic inducible factor-2alpha (HIF-2α) and hepatocellular carcinoma (HCC) by meta-analysis.
  
  
  METHODS
  This study was carried out at Anhui Province Hospital, Hefei, Anhui, China in February 2014. We searched various databases for studies published in English or Chinese up to February 28, 2014. The hazard ratio for overall survival and analyzed odds ratio were combined to evaluate the clinicopathological features of HIF-2α expression in HCC.
  
  
  RESULTS
  A total of 7 eligible studies comprising 1066 patients with HCC were identified after our full assessment according to inclusion criteria. All of the patients came from China. The results indicated that the association between HIF-2α expression and prognostic values in HCC was inconspicuous, while the expression of HIF-2α was significantly associated with capsule infiltration, vein invasion, and histological grade.
  
  
  CONCLUSIONS
  Expression of HIF-2α was associated with invasion and metastasis in HCC, but did not have a distinct significance in prognosis, according to the limited evidence. However, high quality, large sample size, and controlled trials are required.
authors.affiliation: Department of Hepatic Surgery, Anhui Provincial Hospital, Hefei, Anhui, China. E-mail. yaoqiyang2014@sina.com.
authors.forename: Qiyang
authors.initials: Q
authors.lastname: Yao
authors.forename: Yang
authors.initials: Y
authors.lastname: Lv
authors.forename: Tingting
authors.initials: T
authors.lastname: Pan
authors.forename: Yongju
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Geliang
authors.initials: G
authors.lastname: Xu
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D000099162:Endothelial PAS Domain-Containing Protein 1