title: Moderate consumption of wine, through both its phenolic compounds and alcohol content, promotes hydroxytyrosol endogenous generation in humans. A randomized controlled trial.
abstract: In humans, urinary hydroxytyrosol (OHTyr) concentrations have been associated to alcohol and wine consumption. To explore the role of wine components on promoting an endogenous OHTyr generation we performed a cross-over, double-blind, randomized controlled clinical trial (n = 28 healthy volunteers). Ethanol (wine and vodka), dealcoholized wine, and placebo were administered. Alcohol, dealcoholized wine, and particularly wine promoted a de novo OHTyr generation in vivo in humans. Potential OHTyr precursors (tyrosine, tyrosol, tyramine) were investigated in rats. Tyrosol was metabolized to OHTyr. Collating both studies, it is postulated that an increased Tyr bioavailability, a shift to a reductive pathway in dopamine and tyramine oxidative metabolism, and the biotransformation of Tyr to OHTyr were mechanisms involved in the OHTyr endogenous generation.
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Cerdanyola, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: Pérez-Mañá
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Cerdanyola, Spain.
authors.forename: Magí
authors.initials: M
authors.lastname: Farré
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Pompeu Fabra University (CEXS-UPF), Barcelona, Spain.|CIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Rodríguez-Morató
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, Cerdanyola, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Papaseit
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|CIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain.
authors.forename: Mitona
authors.initials: M
authors.lastname: Pujadas
authors.affiliation: CIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain.|Cardiovascular Risk and Nutrition Research Group, Epidemiology Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Fitó
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Pompeu Fabra University (CEXS-UPF), Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Robledo
authors.affiliation: CIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain.|Cardiovascular Risk and Nutrition Research Group, Epidemiology Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|NUPROAS Handesbolag (NUPROAS HB), Nacka, Sweden.
authors.forename: Maria-Isabel
authors.initials: MI
authors.lastname: Covas
authors.affiliation: INRA, UMR1083 SPO, Plateforme polyphénols, Montpellier, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Cheynier
authors.affiliation: INRA, UMR1083 SPO, Plateforme polyphénols, Montpellier, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Meudec
authors.affiliation: INRA Pech Rouge-UE0999, Gruissan, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Escudier
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.|Pompeu Fabra University (CEXS-UPF), Barcelona, Spain.|CIBER de Fisiopatología Obesidad y Nutrición, Santiago de Compostela, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: de la Torre
mesh_terms: D000328:Adult; D000818:Animals; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D018592:Cross-Over Studies; D004298:Dopamine / Q000378:metabolism; D004311:Double-Blind Method; D000431:Ethanol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D010636:Phenols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D051381:Rats; D014439:Tyramine / Q000378:metabolism; D014920:Wine
chemical_list: D010636:Phenols; C005975:3,4-dihydroxyphenylethanol; C011867:4-hydroxyphenylethanol; D000431:Ethanol; D010626:Phenylethyl Alcohol; D004298:Dopamine; D014439:Tyramine
keywords: Alcohol; Dopamine metabolism; Hydroxytyrosol; Tyrosol; Wine