title: Construction of anti-parallel G-quadruplexes through sequential templated click.
abstract: Biologically relevant DNA sequences were assembled onto addressable cyclopeptide scaffolds through sequential oxime and CuAAc reactions. The resulting conjugates are able to fold into well-defined anti-parallel DNA G-quadruplex structures, which exhibit high stability and reduced polymorphism.
authors.affiliation: Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS UMR 5250, F-38000 Grenoble, France. thomas.lavergne@ujf-grenoble.fr eric.defrancq@ujf-grenoble.fr.
authors.forename: Romaric
authors.initials: R
authors.lastname: Bonnet
authors.forename: Thomas
authors.initials: T
authors.lastname: Lavergne
authors.forename: Béatrice
authors.initials: B
authors.lastname: Gennaro
authors.forename: Nicolas
authors.initials: N
authors.lastname: Spinelli
authors.forename: Eric
authors.initials: E
authors.lastname: Defrancq
mesh_terms: D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D058977:Molecular Sequence Annotation; D010091:Oximes; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D010091:Oximes; D010456:Peptides, Cyclic; D004247:DNA