title: New contribution to the study of ventricular remodeling and valve rings in dilated cardiomyopathy: anatomical and histological evaluation.
abstract: BACKGROUND
  Idiopathic dilated cardiomyopathy causes great impact but many aspects of its pathophysiology remain unknown.
  
  
  OBJECTIVE
  To evaluate anatomical and histological aspects of hearts with idiopathic dilated cardiomyopathy and compare them to a control group, evaluating the behavior of the perimeters of the atrioventricular rings and ventricles and to compare the percentage of collagen and elastic fibers of the atrioventricular rings.
  
  
  METHODS
  Thirteen hearts with cardiomyopathy and 13 normal hearts were analysed. They were dissected keeping the ventricular mass and atrioventricular rings, with lamination of segments 20%, 50% and 80% of the distance between the atrioventricular groove and the ventricular apex. The sections were subjected to photo scanning, with measurement of perimeters. The atrioventricular rings were dissected and measured digitally to evaluate their perimeters, later being sent to the pathology laboratory, and stained by hematoxylin-eosin, picrosirius and oxidized resorcin fuccin.
  
  
  RESULTS
  Regarding to ventricles, dilation occurs in all segments in the pathological group, and the right atrioventricular ring measurement was higher in idiopathic dilated cardiomyopathy group, with no difference in the left side. With respect to collagen, both sides had lower percentage of fibers in the pathological group. With respect to the elastic fibers, there was no difference between the groups.
  
  
  CONCLUSIONS
  There is a change in ventricular geometry in cardiomyopathy group. The left atrioventricular ring does not dilate, in spite of the fact that in both ventricles there is lowering of collagen.
authors.affiliation: Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Moise
authors.initials: M
authors.lastname: Dalva
authors.affiliation: Museu Anátomo Cirúrgico do Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Aristides Tadeu
authors.initials: AT
authors.lastname: Correia
authors.affiliation: Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Natalia de Freitas
authors.initials: Nde F
authors.lastname: Jatene
authors.affiliation: Departamento de Patologia do Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Paulo Hilário Nascimento
authors.initials: PH
authors.lastname: Saldiva
authors.affiliation: Instituto do Coração do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Fabio Biscegli
authors.initials: FB
authors.lastname: Jatene
mesh_terms: D000704:Analysis of Variance; D002311:Cardiomyopathy, Dilated / Q000473:pathology*; D003094:Collagen / Q000032:analysis; D004547:Elastic Tissue / Q000033:anatomy & histology / Q000473:pathology; D006351:Heart Valves / Q000033:anatomy & histology / Q000473:pathology*; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000473:pathology*; D006801:Humans; D012016:Reference Values; D018709:Statistics, Nonparametric; D020257:Ventricular Remodeling
chemical_list: D003094:Collagen