title: Emerging Influence of the Intestinal Microbiota during Allogeneic Hematopoietic Cell Transplantation: Control the Gut and the Body Will Follow.
abstract: The intestinal microbiota has many critical roles in maintaining gastrointestinal epithelial and gastrointestinal systemic immune homeostasis. This review provides insight into how allogeneic hematopoietic cell transplantation (HCT) and its associated complications and supportive care therapies affect the microbiota. Additionally, the review discusses how preservation and restoration of the microbiota might be advantageous in decreasing HCT-related morbidity and mortality.
authors.affiliation: Department of Immunology, Weill Cornell Graduate School of Medical Sciences, New York, New York. Electronic address: med2013@med.cornell.edu.
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Docampo
authors.affiliation: Host Defense Program, Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Jeffery J
authors.initials: JJ
authors.lastname: Auletta
authors.affiliation: Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, New York.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Jenq
mesh_terms: D000069196:Gastrointestinal Microbiome / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D064307:Microbiota / Q000502:physiology*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods*
keywords: Antimicrobial peptide; Bacteremia; Bone marrow transplant; Clostridium difficile; Dysbiosis; Enterocyte; Graft-versus-host disease; Gut microbiota; IL-22; Paneth cell; Regenerating islet-derived III alpha; T cell; Tolerance