title: Short-term effect of strontium- and zinc-containing toothpastes and mouthrinses on volatile sulphur compounds in morning breath: a randomized, double-blind, cross-over clinical study.
abstract: Zinc (Zn) reduces the formation of volatile sulphur compounds (VSCs) associated with oral malodour. Although strontium (Sr) is included in some products for reducing dental hypersensitivity, it may also have anti-halitosis properties. This randomized, double-blind, cross-over clinical study compared the anti-VSC effect of brushing with commercial toothpastes and rinses containing Zn and Sr. The volunteers (n = 30) either brushed/rinsed with/without tongue brushing using Zn-containing toothpaste/rinse, Sr-containing toothpaste/rinse, or placebo (control). Volatile sulphur compounds [hydrogen sulphide (H2 S) and methyl mercaptan (CH3 SH)] were measured, in morning breath, using gas chromatography. The anti-VSC effects of the test toothpastes and test rinses were significantly better than the anti-VSC effects of the respective controls. Toothbrushing with test toothpastes gave median reductions, compared with the control, of 70% for H2 S and 55-57% for CH3 SH. Rinsing with the Sr- and Zn-containing solutions had the same anti-VSC effect as toothbrushing and tooth- and tongue brushing with the Sr- and Zn-containing toothpastes. Zinc-containing rinse resulted in a significantly higher median salivary level of Zn compared with brushing with Zn-containing toothpaste, although this effect did not correlate with the anti-VSC effect. It can be concluded that the Sr- and Zn-containing toothpastes and the Zn- and Sr-containing rinses, when used in the evening, are equally effective in reducing morning-breath VSCs the following day.
authors.affiliation: Department of Periodontology, Universidade Estadual do Rio, Rio de Janeiro-RJ, Brazil.
authors.forename: Léo G
authors.initials: LG
authors.lastname: Soares
authors.forename: Grazyna
authors.initials: G
authors.lastname: Jonski
authors.forename: Eduardo M B
authors.initials: EM
authors.lastname: Tinoco
authors.forename: Alix
authors.initials: A
authors.lastname: Young
mesh_terms: D018592:Cross-Over Studies; D004311:Double-Blind Method; D006209:Halitosis / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis; D009067:Mouthwashes / Q000627:therapeutic use*; D010919:Placebos; D013324:Strontium / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000032:analysis; D013457:Sulfur Compounds / Q000032:analysis / Q000037:antagonists & inhibitors*; D014059:Tongue / Q000187:drug effects; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*; D055549:Volatile Organic Compounds / Q000032:analysis / Q000037:antagonists & inhibitors*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D009067:Mouthwashes; D010919:Placebos; D013438:Sulfhydryl Compounds; D013457:Sulfur Compounds; D014100:Toothpastes; D055549:Volatile Organic Compounds; C005231:methylmercaptan; D015032:Zinc; D006862:Hydrogen Sulfide; D013324:Strontium
keywords: gas chromatography; halitosis; strontium; volatile sulphur compound; zinc