title: Cell assemblies of the basal forebrain.
abstract: The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive afferents. This architecture enables the basal forebrain to selectively modulate cortical responsiveness according to current processing demands. Theoretically, optimal functioning of this distributed network would be enhanced by temporal coordination among coactive basal forebrain neurons, or the emergence of "cell assemblies." The present work demonstrates assembly formation in rat basal forebrain neuronal populations during a selective attention task. Neuron pairs exhibited coactivation patterns organized within beta-frequency time windows (55 ms), regardless of their membership within distinct bursting versus nonbursting basal forebrain subpopulations. Thus, the results reveal a specific temporal framework for integration of information within basal forebrain networks and for the modulation of cortical responsiveness.
authors.affiliation: University of California, San Diego Department of Cognitive Science, San Diego, California 92093-0515, and NYU Neuroscience Institute, School of Medicine, New York University, New York, New York 10016.
authors.forename: David
authors.identifier: http://orcid.org/0000-0003-4263-0476
authors.initials: D
authors.lastname: Tingley
authors.affiliation: University of California, San Diego Department of Cognitive Science, San Diego, California 92093-0515, and.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Alexander
authors.affiliation: University of California, San Diego Department of Cognitive Science, San Diego, California 92093-0515, and.
authors.forename: Laleh K
authors.initials: LK
authors.lastname: Quinn
authors.affiliation: University of California, San Diego Department of Cognitive Science, San Diego, California 92093-0515, and.
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Chiba
authors.affiliation: University of California, San Diego Department of Cognitive Science, San Diego, California 92093-0515, and dnitz@ucsd.edu.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Nitz
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001288:Attention / Q000502:physiology*; D066187:Basal Forebrain / Q000166:cytology*; D001611:Beta Rhythm / Q000502:physiology; D008297:Male; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000145:classification* / Q000502:physiology*; D010775:Photic Stimulation; D051381:Rats; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors
keywords: assembly; beta; corticopetal; generalized linear model