title: Acquired haemophilia A presenting at a District General Hospital.
abstract: We report a case of a 64-year-old man presented to A&E with a 2-week to 4-month history of right hip pain, right leg weakness and fasciculations, extensive bruising and a vesicular skin rash. He had a CT of the chest/abdomen/pelvis, which revealed multiple extensive haematomas including an iliopsoas haematoma causing a lumbar plexopathy and resulting in the right hip and leg symptoms. He had clotting studies showing a prolonged activated partial thromboplastin time. Haematology review together with mixing studies suggested a diagnosis of acquired haemophilia A. He was treated at the local tertiary centre with activated prothrombin complex concentrate and steroids and made a full recovery.
authors.affiliation: Barts Health NHS Trust, London, UK.
authors.forename: Amy
authors.initials: A
authors.lastname: Freeman
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D002097:C-Reactive Protein; D003937:Diagnosis, Differential; D006454:Hemoglobins; D006467:Hemophilia A / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D006769:Hospitals, General; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D006454:Hemoglobins; D014148:Tranexamic Acid; D002097:C-Reactive Protein; C065655:anti-inhibitor coagulant complex