title: [New markers of progression of chronic heart failure in patients with myocardial infarction, type 2 diabetes and obesity].
abstract: Currently identified a large number of biomarkers that are closely linked with the development of chronic heart failure, some of which are clusterin and fractalkine. Accordingly, the purpose of our study was - to evaluate the role of clusterin and fractalkine in progression of chronic heart failure in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. We investigated 71 patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. All patients with postinfarction cardiosclerosis, diabetes and obesity were divided into groups according to the functional class of chronic heart failure (CHF). It was found that an increase the level of fractalkine and reduced clusterin leads due to the development of systolic dysfunction and heart failure progression in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity. Fractalkine and clusterin play an important role in progression of the heart failure in patients with postinfarction cardiosclerosis, type 2 diabetes and obesity, and this gives them the right to be considered indicators of the severity of CHF.
authors.forename: P P
authors.initials: PP
authors.lastname: Kravchun
authors.forename: O I
authors.initials: OI
authors.lastname: Kadykova
authors.forename: T N
authors.initials: TN
authors.lastname: Gabisonia
mesh_terms: D054428:Chemokine CX3CL1 / Q000097:blood*; D051152:Clusterin / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications; D018450:Disease Progression; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications; D009765:Obesity / Q000097:blood / Q000150:complications
chemical_list: C495242:CLU protein, human; C515538:CX3CL1 protein, human; D054428:Chemokine CX3CL1; D051152:Clusterin