title: Structural plasticity of the circadian timing system. An overview from flies to mammals.
abstract: The circadian timing system orchestrates daily variations in physiology and behavior through coordination of multioscillatory cell networks that are highly plastic in responding to environmental changes. Over the last decade, it has become clear that this plasticity involves structural changes and that the changes may be observed not only in central brain regions where the master clock cells reside but also in clock-controlled structures. This review considers experimental data in invertebrate and vertebrate model systems, mainly flies and mammals, illustrating various forms of structural circadian plasticity from cellular to circuit-based levels. It highlights the importance of these plastic events in the functional adaptation of the clock to the changing environment.
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M, UMR 7286, Faculté de médecine, secteur nord, Boulevard Pierre Dramard, CS 80011, F-13344 Marseille cedex 15, France. Electronic address: olivier.bosler@univ-amu.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Bosler
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M, UMR 7286, Faculté de médecine, secteur nord, Boulevard Pierre Dramard, CS 80011, F-13344 Marseille cedex 15, France. Electronic address: girardetc@slu.edu.
authors.forename: Clémence
authors.initials: C
authors.lastname: Girardet
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M, UMR 7286, Faculté de médecine, secteur nord, Boulevard Pierre Dramard, CS 80011, F-13344 Marseille cedex 15, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Franc
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M, UMR 7286, Faculté de médecine, secteur nord, Boulevard Pierre Dramard, CS 80011, F-13344 Marseille cedex 15, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Becquet
authors.affiliation: Aix-Marseille Université, CNRS, CRN2M, UMR 7286, Faculté de médecine, secteur nord, Boulevard Pierre Dramard, CS 80011, F-13344 Marseille cedex 15, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: François-Bellan
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
keywords: Cell network; Circadian clock; Glial plasticity; Paraspeckles; Rhythm; Structural plasticity; Suprachiasmatic nucleus; Synapse remodeling