title: Autoantibodies to plasminogen and their role in tumor diseases.
abstract: Plasma level of IgG autoantibodies to plasminogen was measured by ELISA in patients with benign prostatic hyperplasia (n=25), prostatic cancer (n=17), lung cancer (n=15), and healthy volunteers (n=44). High levels of IgG to plasminogen were found in 2 (12%) of 17 healthy women, in 1 (3.6%) of 27 specimens in a healthy man, in 17 (68%) of 25 specimens in prostatic cancer, in 10 (59%) of 17 specimens in lung cancer, and in 5 (30%) of 15 specimens in benign prostatic hyperplasia. Comparison of plasma levels of anti-plasminogen IgG by affinity chromatography showed 3-fold higher levels in patients with prostatic cancer vs. healthy men.
authors.affiliation: Research Institute of Physicochemical Medicine, Federal Biomedical Agency of Russia, Moscow, Russia, vavilov01@mail.ru.
authors.forename: E I
authors.initials: EI
authors.lastname: Goufman
authors.forename: V N
authors.initials: VN
authors.lastname: Yakovlev
authors.forename: N B
authors.initials: NB
authors.lastname: Tikhonova
authors.forename: R B
authors.initials: RB
authors.lastname: Aisina
authors.forename: K N
authors.initials: KN
authors.lastname: Yarygin
authors.forename: L I
authors.initials: LI
authors.lastname: Mukhametova
authors.forename: K B
authors.initials: KB
authors.lastname: Gershkovich
authors.forename: D A
authors.initials: DA
authors.lastname: Gulin
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D002846:Chromatography, Affinity; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000276:immunology*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D010958:Plasminogen