title: Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population.
abstract: OBJECTIVE
  We investigated the association of genetic factors with primary open angle glaucoma (POAG), including high tension glaucoma (HTG) and normal tension glaucoma (NTG), in a Han Chinese population.
  
  
  METHODS
  We recruited 1157 POAG cases, including 860 HTG and 297 NTG, and 934 normal controls. A total of 13 previously reported single nucleotide polymorphisms (SNPs) located at four gene regions (TMCO1, CDKN2B-AS1, ATOH7, and SIX1/SIX6) was genotyped. Distributions of allele frequencies were compared between cases and controls as well as in the HTG and NTG subgroups. The IOP, vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT), axial length (AL), and age at diagnosis also were investigated as quantitative phenotypes with genotypes of these SNPs.
  
  
  RESULTS
  The SNPs rs4656461 and rs7555523 at TMCO1, rs523096 and rs2157719 at CDKN2B-AS1, as well as rs33912345 and rs10483727 at SIX1/SIX6 showed statistically significant association with POAG. The SNPs at ATOH7 did not show statistically significant association with POAG in our dataset. In the subgroup analysis of HTG and NTG, multiple variants at CDKN2B-AS1 and SIX1/SIX6 showed stronger association with NTG than HTG. The SNPs rs523096 and rs2157719 at CDKN2B-AS1 as well as rs33912345 and rs10483727 at SIX1/SIX6 were found to be associated with IOP where the minor alleles were associated with an increase in IOP. In contrast, SNPs at TMCO1 showed significant association with HTG only.
  
  
  CONCLUSIONS
  Genetic variants in CDKN2B-AS1, SIX1/SIX6, and TMCO1 were associated with POAG in a Han Chinese population. Genes CDKN2B-AS1 and SIX1/SIX6 seem to harbor a tendency toward POAG with lower IOP, while carriers of risk alleles at TMCO1 seem to be predisposed to developing POAG with higher IOP.
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: University of California Irvine School of Medicine, Irvine, California, United States.
authors.forename: Guy
authors.initials: G
authors.lastname: Hughes
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Xueli
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Shaohong
authors.initials: S
authors.lastname: Qian
authors.affiliation: Department of Clinical Laboratory, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Cao
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology and Vision Science, Shanghai Medical College, Eye and Ear Nose Throat Hospital, Fudan University, Shanghai, China 4State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
mesh_terms: D002681:China / Q000453:epidemiology; D004247:DNA / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors
chemical_list: D004247:DNA