title: Improvement of bisphenol A quantitation from urine by LCMS.
abstract: Bisphenol A (BPA) is a synthetic chemical extensively used in many consumer products. It mimics estrogen activities and is related to developmental disorders and metabolic diseases. The current challenge of BPA detection is their low circulating levels at 0.1∼10 ng/mL which is close to the detection limit of most of current analytical methods. In this report, we developed a simple, sensitive, and accurate liquid chromatography mass spectrometry (LCMS) method after 1-methylimidazole-2-sulfonyl chloride derivatization. The method significantly improves sensitivity 5∼9-fold over dansyl derivatization and approximately 100-fold without derivatization.
authors.affiliation: University of Hawai'i Cancer Center, 701 Ilalo Street, Honolulu, HI, 96813, USA, Lixn@cc.hawaii.edu.
authors.forename: Xingnan
authors.initials: X
authors.lastname: Li
authors.forename: Adrian A
authors.initials: AA
authors.lastname: Franke
mesh_terms: D001559:Benzhydryl Compounds / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004785:Environmental Pollutants / Q000652:urine*; D006801:Humans; D010636:Phenols / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D016482:Urinalysis / Q000379:methods*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds