title: Regulation of lipid production by light-emitting diodes in human sebocytes.
abstract: Light-emitting diodes (LED) have been used to treat acne vulgaris. However, the efficacy of LED on sebaceous lipid production in vitro has not been examined. This study investigated the efficacy of 415 nm blue light and 630 nm red light on lipid production in human sebocytes. When applied to human primary sebocytes, 415 nm blue light suppressed cell proliferation. Based on a lipogenesis study using Oil Red O, Nile red staining, and thin-layered chromatography, 630 nm red light strongly downregulated lipid production in sebocytes. These results suggest that 415 nm blue light and 630 nm red light influence lipid production in human sebocytes and have beneficial effects on acne by suppressing sebum production.
authors.affiliation: Department of Dermatology, College of Medicine, Chungnam National University, 282-Munhwa-ro, Jung-Gu, Daejeon, 301-721, Korea.
authors.forename: Yu Ra
authors.initials: YR
authors.lastname: Jung
authors.forename: Sue Jeong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kyung Cheol
authors.initials: KC
authors.lastname: Sohn
authors.forename: Young
authors.initials: Y
authors.lastname: Lee
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Seo
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Kyu Uang
authors.initials: KU
authors.lastname: Whang
authors.forename: Chang Deok
authors.initials: CD
authors.lastname: Kim
authors.forename: Jeung Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Myung
authors.initials: M
authors.lastname: Im
mesh_terms: D000152:Acne Vulgaris / Q000532:radiotherapy*; D049109:Cell Proliferation / Q000528:radiation effects; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D006801:Humans; D054023:Lasers, Semiconductor / Q000009:adverse effects / Q000627:therapeutic use*; D008055:Lipids / Q000096:biosynthesis*; D050155:Lipogenesis / Q000528:radiation effects; D028022:Low-Level Light Therapy; D061251:Primary Cell Culture; D012627:Sebaceous Glands / Q000473:pathology; D012629:Sebum / Q000378:metabolism* / Q000528:radiation effects
chemical_list: D008055:Lipids