title: Effects of Clostridium butyricum on growth performance, antioxidation, and immune function of broilers.
abstract: To investigate the effects of Clostridium butyricum on growth performance, antioxidation, and immune function of broilers, 320 one-day-old Arbor Acres commercial male chicks were assigned to one of 5 treatments with 8 replicates in a completely randomized design for 42 d. The 5 treatments were basal diet (control), basal diet supplemented with 2.5×10(8) cfu C. butyricum/kg (CB1), basal diet supplemented with 5×10(8) cfu C. butyricum/kg (CB2), basal diet supplemented with 1×10(9) cfu C. butyricum/kg (CB3), and basal diet supplemented with 150 mg aureomycin/kg (antibiotic). The results showed that all C. butyricum-supplemented groups during d 1 to 21 and the CB2 group during d 22 to 42 had higher ADG compared with the control (P<0.05). Chicks fed the CB3 diet had higher glutathione S-transferase (GST) activity (P<0.05), and chicks fed the CB2 diet had a higher glutathione (GSH) concentration in duodenal and ileal mucosa at 21 d of age than those in the control group (P<0.05). Chicks fed the CB3 diet had a lower malondialdehyde (MDA) concentration in duodenal mucosa than those in the control and CB1 groups (P<0.05). Chicks fed the CB2, CB3, and antibiotic diets had a lower MDA concentration in ileal mucosa than those in the control and CB1 groups (P<0.05). Broilers fed the CB3 diet had greater superoxide dismutase (SOD) activity in the ileal mucosa on d 21 and in jejunal mucosa on d 42 than those in the other groups (P<0.05). Chicks fed the CB2, CB3, and antibiotic diets had a higher GSH concentration in duodenal and jejunal mucosa on d 42 than those in the control group (P<0.05). Broilers fed the CB2 and CB3 diets had a lower MDA concentration in the jejunal mucosa on d 42 than those in the control and CB1 groups. Chicks fed diets supplemented with C. butyricum had a higher IgM concentration than those in the control group at 21 and 42 d of age (P<0.05). The results indicate that C. butyricum improves broilers' growth performance, antioxidation, and immune function.
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: X D
authors.initials: XD
authors.lastname: Liao
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: G
authors.initials: G
authors.lastname: Ma
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: J
authors.initials: J
authors.lastname: Cai
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Yan
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.
authors.forename: X B
authors.initials: XB
authors.lastname: Wei
authors.affiliation: Laboratory of Feed Biotechnology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China zhangrj621@126.com.
authors.forename: R J
authors.initials: RJ
authors.lastname: Zhang
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena / Q000187:drug effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism*; D002645:Chickens / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D002751:Chlortetracycline / Q000008:administration & dosage / Q000494:pharmacology; D046972:Clostridium butyricum / Q000737:chemistry*; D004032:Diet / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D002751:Chlortetracycline
keywords: Clostridium butyricum; antioxidation; broiler; immune function