title: Structure-Function Correlation Using Confocal Laser Ophthalmoscope in Primary Open-Angle Glaucoma and Pseudoexfoliative Glaucoma.
abstract: OBJECTIVE
  To compare Heidelberg Retina Tomograph (HRT) optic disc parameters and structure-function correlation between primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG).
  
  
  METHODS
  Prospective, observation case series.
  
  
  METHODS
  A total of 54 POAG and 33 PEXG cases, consecutively recruited from a University Glaucoma Service, underwent a comprehensive ophthalmic examination, including HRT optic disc imaging. Glaucoma definition required the presence of both structural and functional damage. One eye per subject was included in the analysis. T test, Mann-Whitney U test, and analysis of covariance were used to compare HRT parameters between POAG and PEXG, adjusting for age, mean deviation (MD) in the visual field, intraocular pressure, and disc area. The correlation between HRT and MD was assessed in each group.
  
  
  RESULTS
  Cup area (P=0.048), height variation contour (P=0.016), and cup/disc area ratio (P=0.023) were higher in POAG, whereas the mean retinal nerve fiber layer thickness (P=0.048), retinal nerve fiber layer cross-section area (P=0.044), and rim area (P=0.048) were lower in POAG, compared with PEXG. The correlation of HRT parameters with MD was significant only in the POAG group.
  
  
  CONCLUSIONS
  At a similar level of functional damage, POAG subjects presented with more pronounced structural damage than PEXG subjects. The correlation between HRT and visual field parameters was more evident in POAG, compared with PEXG.
authors.affiliation: *1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece †National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Theofanis
authors.initials: T
authors.lastname: Pappas
authors.forename: Panayiota
authors.initials: P
authors.lastname: Founti
authors.forename: Xiang Jun
authors.initials: XJ
authors.lastname: Yin
authors.forename: Archimidis
authors.initials: A
authors.lastname: Koskosas
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Anastasopoulos
authors.forename: Angeliki
authors.initials: A
authors.lastname: Salonikiou
authors.forename: Vasilios
authors.initials: V
authors.lastname: Kilintzis
authors.forename: Antonios
authors.initials: A
authors.lastname: Antoniadis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Ziakas
authors.forename: Fotis
authors.initials: F
authors.lastname: Topouzis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017889:Exfoliation Syndrome / Q000175:diagnosis*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D014054:Tomography; D014065:Tonometry, Ocular; D014794:Visual Fields / Q000502:physiology