title: Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates.
abstract: Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), C/ Jenaro de la Fuente s/n, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. joseluis.mascarenas@usc.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Mosquera
authors.forename: Mateo I
authors.initials: MI
authors.lastname: Sánchez
authors.forename: Julián
authors.initials: J
authors.lastname: Valero
authors.forename: Javier
authors.initials: J
authors.lastname: de Mendoza
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D000818:Animals; D001483:Base Sequence; D050976:Basic-Leucine Zipper Transcription Factors / Q000737:chemistry; D002522:Chlorocebus aethiops; D019295:Computational Biology; D004247:DNA / Q000737:chemistry*; D019791:Guanidine / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D010455:Peptides; D004247:DNA; D019791:Guanidine