title: Cannabis abuse effects on prepulse inhibition in patients with first episode psychosis in schizophrenia.
abstract: Deficits in prepulse inhibition (PPI) and cannabis abuse are consistently found in schizophrenia. The authors studied PPI deficits in first episode psychosis (FEP) with schizophrenia and cannabis abuse influence. Thirty-five patients with FEP and 22 control subjects were examined. Patients were divided into cannabis use disorder (CUD) (N=21) and non-CUD (N=14). Startle measures were as follows: PPI at 30, 60, and 120 msec. Patients with CUD and patients without CUD showed lower PPI at 30 msec than control subjects. At 60 msec, patients with CUD obtained higher %PPI than patients without CUD, and patients without CUD obtained lower levels than control subjects. These findings show that cannabis abuse may improve PPI in patients with FEP at some levels.
authors.affiliation: From the Laboratory of Clinical Psychophysiology. Dept. of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain (IM-M); Dept. of Psychiatry, Hospital Universitario 12 de Octubre, Madrid, Spain (RJ-B); Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain (MC); Dept. of Psychiatry, School of Medicine, Complutense University of Madrid, Madrid, Spain (SF-G); and Dept. of Basic Psychology II (Cognitive Processes), School of Psychology, Complutense University of Madrid, Madrid, Spain (GR).
authors.forename: Isabel
authors.initials: I
authors.lastname: Morales-Muñoz
authors.forename: Rosa
authors.initials: R
authors.lastname: Jurado-Barba
authors.forename: Montserrat
authors.initials: M
authors.lastname: Caballero
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Jiménez
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Jiménez-Arriero
authors.forename: Sara
authors.initials: S
authors.lastname: Fernández-Guinea
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rubio
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000503:physiopathology*; D065808:Prepulse Inhibition / Q000502:physiology*; D011618:Psychotic Disorders / Q000209:etiology*; D013216:Reflex, Startle; D012559:Schizophrenia / Q000150:complications*; D013030:Spain; D055815:Young Adult