title: Analysis of microRNA expression profile identifies novel biomarkers for non-small cell lung cancer.
abstract: BACKGROUND
  Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer mortality. MicroRNAs (miRNAs), small noncoding RNAs, regulate the expression of genes that play roles in human cancer via posttranscriptional inhibition.
  
  
  METHODS
  To identify the potential miRNA biomarkers in NSCLC, we downloaded the miRNA expression profile (ID: GSE29248) of NSCLC from the Gene Expression Omnibus (GEO) database and analyzed the differentially expressed miRNAs in NSCLC tissue compared with normal control tissue. Then the targets of these differentially expressed miRNAs were screened and used in network construction and functional enrichment analysis.
  
  
  RESULTS
  We identified a total of 17 miRNAs that showed a significantly differential expression in NSCLC tissue. We found that miR-34b and miR-520h might play important roles in the regulation of NSCLC, miR-22 might be a novel biomarker as an oncogene, and miR-448 might promote, while miR-654-3p prevents, NSCLC progression.
  
  
  CONCLUSIONS
  Our study may provide the groundwork for further clinical molecular target therapy experiments in NSCLC.BAC
authors.forename: Chi
authors.initials: C
authors.lastname: Xu
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Zheng
authors.forename: Duohuang
authors.initials: D
authors.lastname: Lian
authors.forename: Shixin
authors.initials: S
authors.lastname: Ye
authors.forename: Jinrong
authors.initials: J
authors.lastname: Yang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zeng
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D040081:Protein Array Analysis
chemical_list: D014408:Biomarkers, Tumor; C548375:MIRN22 microRNA, human; C522425:MIRN34 microRNA, human; C557400:MIRN448 microRNA, human; C575048:MIRN520 microRNA, human; D035683:MicroRNAs