title: Fungal genome sequencing: basic biology to biotechnology.
abstract: The genome sequences provide a first glimpse into the genomic basis of the biological diversity of filamentous fungi and yeast. The genome sequence of the budding yeast, Saccharomyces cerevisiae, with a small genome size, unicellular growth, and rich history of genetic and molecular analyses was a milestone of early genomics in the 1990s. The subsequent completion of fission yeast, Schizosaccharomyces pombe and genetic model, Neurospora crassa initiated a revolution in the genomics of the fungal kingdom. In due course of time, a substantial number of fungal genomes have been sequenced and publicly released, representing the widest sampling of genomes from any eukaryotic kingdom. An ambitious genome-sequencing program provides a wealth of data on metabolic diversity within the fungal kingdom, thereby enhancing research into medical science, agriculture science, ecology, bioremediation, bioenergy, and the biotechnology industry. Fungal genomics have higher potential to positively affect human health, environmental health, and the planet's stored energy. With a significant increase in sequenced fungal genomes, the known diversity of genes encoding organic acids, antibiotics, enzymes, and their pathways has increased exponentially. Currently, over a hundred fungal genome sequences are publicly available; however, no inclusive review has been published. This review is an initiative to address the significance of the fungal genome-sequencing program and provides the road map for basic and applied research.
authors.affiliation: a Laboratory of Enzymology and Recombinant DNA Technology, Department of Microbiology , Maharshi Dayanand University , Rohtak , Haryana , India.
authors.forename: Krishna Kant
authors.initials: KK
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001709:Biotechnology; D016208:Databases, Factual; D019649:Food Industry; D005658:Fungi / Q000235:genetics / Q000378:metabolism; D016681:Genome, Fungal; D006801:Humans; D008031:Lignin / Q000378:metabolism; D010935:Plant Diseases; D017422:Sequence Analysis, DNA
chemical_list: D008031:Lignin
keywords: Bioenergy; biotechnology; database; fungus; gene; genome; pathogen