title: Stereotactic body radiotherapy for prostate cancer.
abstract: The use of stereotactic body radiotherapy (SBRT) for localised prostate cancer is now supported by a substantial body of non-randomised data, with medium-term outcomes consistent with current standard radiotherapy. The ability to deliver profoundly hypofractionated treatment, combined with the relatively low α/β ratio of prostate cancer, may result in a more favourable therapeutic ratio, presenting an opportunity for isotoxic dose escalation. Furthermore, as treatment can be given in five attendances, SBRT has the potential both to reduce costs and improve patient quality of life. However, in a treatment landscape with many competing options of broadly similar efficacy, randomised trials are essential to define the relative benefits of this approach. SBRT also has an emerging application in oligometastatic prostate cancer, with promising early outcomes for delaying disease progression and deferring the need for androgen deprivation therapy.
authors.affiliation: Academic Uro-oncology Department, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Henderson
authors.affiliation: Academic Uro-oncology Department, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Tree
authors.affiliation: Academic Uro-oncology Department, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK. Electronic address: Nicholas.vanAs@rmh.nhs.uk.
authors.forename: N J
authors.initials: NJ
authors.lastname: van As
mesh_terms: D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated
keywords: Hypofractionation; image-guided radiotherapy; intrafraction motion; oligometastatic; prostate cancer; stereotactic radiotherapy