title: Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma.
abstract: Infantile hemangiomas (IHs) are the most common benign tumor of infancy, characterized by a natural history of early proliferation in the first months of life to eventual involution during childhood, often with residual fibrofatty tissue. Once involution has been achieved, IHs do not typically recur. We present two cases of exogenous growth hormone therapy resulting in the recurrence of IHs in late childhood, supported by radiological, immunohistochemical, in vitro, and in vivo evidence.
authors.affiliation: Division of Plastic Surgery, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: Naikhoba C O
authors.initials: NC
authors.lastname: Munabi
authors.affiliation: Division of Plastic Surgery, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: Qian Kun
authors.initials: QK
authors.lastname: Tan
authors.affiliation: Division of Pediatric Dermatology, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Garzon
authors.affiliation: Division of Pediatric Radiology, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: Gerald G
authors.initials: GG
authors.lastname: Behr
authors.affiliation: Department of Obstetrics and Gynecology, Columbia University Medical Center, New York-Presbyterian Hospital, New York.|Department of Surgery, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: Carrie J
authors.initials: CJ
authors.lastname: Shawber
authors.affiliation: Division of Plastic Surgery, Columbia University Medical Center, New York-Presbyterian Hospital, New York.
authors.forename: June K
authors.initials: JK
authors.lastname: Wu
mesh_terms: D001706:Biopsy; D002648:Child; D005260:Female; D006391:Hemangioma / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000172:deficiency; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
chemical_list: D019382:Human Growth Hormone