title: Photoswitching the cytotoxic properties of platinum(II) compounds.
abstract: The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of "photomodifying" a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2-dithienylethene-containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA-interacting properties and cytotoxic behaviors.
authors.affiliation: Departament de Química Inorgànica, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona (Spain).
authors.forename: Andreu
authors.initials: A
authors.lastname: Presa
authors.forename: Rosa F
authors.initials: RF
authors.lastname: Brissos
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Caballero
authors.forename: Ivana
authors.initials: I
authors.lastname: Borilovic
authors.forename: Luís
authors.initials: L
authors.lastname: Korrodi-Gregório
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pérez-Tomás
authors.forename: Olivier
authors.initials: O
authors.lastname: Roubeau
authors.forename: Patrick
authors.initials: P
authors.lastname: Gamez
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D017319:Photosensitizing Agents; D004247:DNA
keywords: cancer; cytotoxicity; drug design; photochemistry; platinum