title: Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection.
abstract: A novel series of fused tetrathiocines were prepared for evaluation of activity against the nucleocapsid protein of the feline immunodeficiency virus (FIV) in an in vitro cell culture approach. The results demonstrated that the compounds display potent nanomolar activity and low toxicity against this key model of HIV infection.
authors.affiliation: UCL School of Pharmacy, Faculty of Life Sciences, University College London, London WC1N 1AX, United Kingdom.
authors.forename: Christopher R M
authors.initials: CR
authors.lastname: Asquith
authors.affiliation: Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland.
authors.forename: Marina L
authors.initials: ML
authors.lastname: Meli
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation.
authors.forename: Lidia S
authors.initials: LS
authors.lastname: Konstantinova
authors.affiliation: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
authors.forename: Tuomo
authors.initials: T
authors.lastname: Laitinen
authors.affiliation: School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Poso
authors.affiliation: Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russian Federation.
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Rakitin
authors.affiliation: Clinical Laboratory and Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, Zurich 8057, Switzerland.
authors.forename: Regina
authors.initials: R
authors.lastname: Hofmann-Lehmann
authors.affiliation: Veterinary Clinical Sciences, Royal Veterinary College, Hatfield AL9 7TA, United Kingdom.
authors.forename: Karin
authors.initials: K
authors.lastname: Allenspach
authors.affiliation: UCL School of Pharmacy, Faculty of Life Sciences, University College London, London WC1N 1AX, United Kingdom. Electronic address: s.hilton@ucl.ac.uk.
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Hilton
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D001549:Benzamides / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D001665:Binding Sites; D002415:Cats; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects / Q000378:metabolism*; D062105:Molecular Docking Simulation; D019590:Nucleocapsid Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D016335:Zinc Fingers
chemical_list: D000998:Antiviral Agents; D001549:Benzamides; D019590:Nucleocapsid Proteins; D013438:Sulfhydryl Compounds
keywords: FIV; HIV; Nucleocapsid; Tetrathiocenes; Zinc finger