title: Placental transfer of rilpivirine in an ex vivo human cotyledon perfusion model.
abstract: Placental transfers of the HIV nonnucleoside reverse transcriptase inhibitor rilpivirine were investigated in 8 term human cotyledons perfused with rilpivirine (400 ng/ml) in the maternal-to-fetal direction. The mean fetal transfer rate (FTR) (fetal/maternal concentration at steady state from 15 to 90 min) was 26% ± 8% (mean ± standard deviation), and the clearance index (rilpivirine FTR/antipyrine FTR) was 61% ± 20%. This shows that rilpivirine crosses the placenta at a relatively high rate, suggesting that the fetus is exposed to the compound during treatment of the mother.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Hôpitaux Universitaires Paris-Nord Val de Seine, Colombes, France Université Paris-Diderot, Université Sorbonne Paris-Cité, DHU Risks in Pregnancy, Paris, France INSERM U1018, Kremlin-Bicêtre, France laurent.mandelbrot@lmr.aphp.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Mandelbrot
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Louis Mourier, Service de Gynécologie-Obstétrique, Hôpitaux Universitaires Paris-Nord Val de Seine, Colombes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Duro
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Clinical Pharmaco-Toxicology Department, Hôpitaux Universitaires Paris-Nord Val de Seine, Paris, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Belissa
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Clinical Pharmaco-Toxicology Department, Hôpitaux Universitaires Paris-Nord Val de Seine, Paris, France IAME, UMR 1137, INSERM, Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Peytavin
mesh_terms: D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D018894:Reverse Transcriptase Inhibitors / Q000378:metabolism*; D000068696:Rilpivirine / Q000378:metabolism*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D000068696:Rilpivirine