title: New bioactive chromanes from Litchi chinensis.
abstract: Seven new δ-tocotrienols, designated litchtocotrienols A-G (1-7), together with one glorious macrocyclic analogue, macrolitchtocotrienol A (8), and one new meroditerpene chromane, cyclolitchtocotrienol A (9), were isolated from the leaves of Litchi chinensis. Their structures were mainly determined by extensive spectroscopic analysis, and their biological activities were evaluated by cytotoxicity against human gastric adenocarcinoma cell lines (AGS, ATCC CRL-1739) and hepatoma carcinoma cell line (HepG2 2.2.1.5). The structure-activity relationship of the isolated compounds was also discussed.
authors.affiliation: Department of Life Sciences and #Department of Engineering Science, National Cheng Kung University , Tainan, Taiwan.
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Jia-Chen
authors.initials: JC
authors.lastname: Chang
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Wang
authors.forename: Yun-Lian
authors.initials: YL
authors.lastname: Jhan
authors.forename: I-Wen
authors.initials: IW
authors.lastname: Lo
authors.forename: Yuan-Man
authors.initials: YM
authors.lastname: Hsu
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Chi-Chuan
authors.initials: CC
authors.lastname: Hwang
authors.forename: Chang-Hung
authors.initials: CH
authors.lastname: Chou
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002839:Chromans / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D032125:Litchi / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D002839:Chromans; D010936:Plant Extracts
keywords: Litchi chinensis; cyclolitchtocotrienol; hepatoma carcinoma cell line; human gastric adenocarcinoma cells; macrolitchtocotrienol; δ-tocotrienol