title: Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia.
abstract: We previously reported that Alzheimer-related pathology in cerebral cortex of APP/PS1 and K3 tau transgenic mouse strains is mitigated by near infrared light (NIr). Here, we extend these observations to the cerebellum. One month of NIr treatment mitigated the deposition of β-amyloid in cerebellar cortex of APP/PS1 mice, and the formation of neurofibrillary tangles, the hyperphosphorylation of tau, the damage caused by oxidative stress and the downregulation of cytochrome oxidase expression by Purkinje cells in the cerebellar cortex of K3 mice. These findings show the ability of NIr to mitigate degeneration in many - probably all - regions of the mouse brain.
authors.affiliation: Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia; Save Sight Institute & Clinical Ophthalmology, University of Sydney & Sydney Eye Hospital, NSW 2000, Australia.
authors.forename: Sivaraman
authors.initials: S
authors.lastname: Purushothuman
authors.affiliation: Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia. Electronic address: Daniel.Johnstone@sydney.edu.au.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Johnstone
authors.affiliation: Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia.
authors.forename: Charith
authors.initials: C
authors.lastname: Nandasena
authors.affiliation: Dementia Research Unit, School of Medical Sciences, University of New South Wales, NSW 2052, Australia.
authors.forename: Janet
authors.initials: J
authors.lastname: van Eersel
authors.affiliation: Dementia Research Unit, School of Medical Sciences, University of New South Wales, NSW 2052, Australia; Neuroscience Research Australia, Sydney, NSW 2031, Australia.
authors.forename: Lars M
authors.initials: LM
authors.lastname: Ittner
authors.affiliation: Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Anatomy & Histology, University of Sydney, NSW 2006, Australia.
authors.forename: John
authors.initials: J
authors.lastname: Mitrofanis
authors.affiliation: Bosch Institute, University of Sydney, NSW 2006, Australia; Discipline of Physiology, University of Sydney, NSW 2006, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Stone
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D003704:Dementia / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D007259:Infrared Rays; D028022:Low-Level Light Therapy; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism; D018384:Oxidative Stress; D058225:Plaque, Amyloid / Q000473:pathology; D053764:Presenilin-1 / Q000235:genetics; D016875:tau Proteins / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor; D053764:Presenilin-1; D016875:tau Proteins
keywords: Dementia; Mouse model; Near infrared light; Neuroprotection