title: Cytotoxin-induced NADPH oxides activation: roles in regulation of cell death.
abstract: Numerous studies have shown that a variety of cytotoxic agents can activate the NADPH oxidase system and induce redox-dependent regulation of cellular functions. Cytotoxin-induced NADPH oxidase activation may either exert cytoprotective actions (e.g., survival, proliferation, and stress tolerance) or cause cell death. Here we summarize the experimental evidence showing the context-dependent dichotomous effects of NADPH oxidase on cell fate under cytotoxic stress conditions and the potential redox signaling mechanisms underlying this phenomenon. Clearly, it is difficult to create a unified paradigm on the toxicological implications of NADPH oxidase activation in response to cytotoxic stimuli. We suggest that interventional strategies targeting the NADPH oxidase system to prevent the adverse impacts of cytotoxins need to be contemplated in a stimuli- and cell type-specific manner.
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, 107 Wen Hua Xi Road, Jinan, 250012, Shandong Province, China.
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Bi
authors.forename: Fan
authors.initials: F
authors.lastname: Jiang
mesh_terms: D000818:Animals; D020261:Arsenic Poisoning / Q000201:enzymology* / Q000473:pathology; D001152:Arsenicals / Q000009:adverse effects*; D016923:Cell Death / Q000187:drug effects; D003603:Cytotoxins / Q000633:toxicity*; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000633:toxicity*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001152:Arsenicals; D003603:Cytotoxins; D020536:Enzyme Activators; D019255:NADPH Oxidases