title: Obtainment of pellets using the standardized liquid extract of Brosimum gaudichaudii Trécul (Moraceae).
abstract: BACKGROUND
  The standardized liquid extract of Brosimum gaudichaudii Trécul is an alternative for the treatment of vitiligo. There is a shortage of solid oral dosage forms developed from standardized extracts of this plant specie.
  
  
  OBJECTIVE
  This study is aimed to obtain pellets with a standardized liquid extract of B. gaudichaudii.
  
  
  RESULTS
  The standardized liquid extract of B. gaudichaudii was obtained through maceration and percolation with a 55% ethanol-water solution (v/v). Pellets were obtained through a mixture of extract of 500 g of B. gaudichaudii standardized extract, 500 g of microcrystalline cellulose PH101 and 10 g of hydroxypropyl methylcellulose K100. The pellets obtained presented a homogeneity yield of 92%, aspect ratio of 1.16 ± 0.65, shape fator e R of 0.35 ± 0.09 and Feret diammeter of 0.87 ± 0.27. These pellets were coated with a suspension composed of titanium dioxide, aluminum red lacquer, ethyl cellulose, talc and magnesium stearate. Before the photostability test, the uncoated pellets showed psoralen content equal to 0.13 ± 0.01% and to the 5-MOP was 1.40 ± 0.27%. After exposure to one level (3 J.cm(-2)) of UVB irradiation the uncoated pellets presented a degradation of 2.16% of psoralen and 8.1% of 5-MOP. After exposure to three levels (10, 20 and 30 J.cm(-2)) of UVA irradiation the uncoated pellets exhibited photodegradation of 9.78, 17.64, 24.21% of psoralen and 18.95, 23.68, 28.48% for 5-MOP. The coated pellets where unaffected after photostability test.
  
  
  CONCLUSIONS
  Pellets were obtained with the standardized liquid extract of B. gaudichaudii and coating is a technological alternative to ensure the stability of the formula.
authors.affiliation: Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
authors.forename: Omar Paulino Silva
authors.initials: OP
authors.lastname: Filho
authors.affiliation: Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
authors.forename: Leandra Almeida Ribeiro
authors.initials: LA
authors.lastname: Oliveira
authors.affiliation: Laboratory of Research, Development and Pharmacotechnical, Faculty of Pharmaceutical Science from Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: Frederico Severino
authors.initials: FS
authors.lastname: Martins
authors.affiliation: Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
authors.forename: Leonardo Luiz
authors.initials: LL
authors.lastname: Borges
authors.affiliation: Laboratory of Research, Development and Pharmacotechnical, Faculty of Pharmaceutical Science from Ribeirão Preto, University of São Paulo, Brazil.
authors.forename: Osvaldo
authors.initials: O
authors.lastname: de Freitas
authors.affiliation: Laboratory of Research, Development and Inovation on Bioproducts, Faculty of Pharmacy, Federal University of Goiás, Brazil.
authors.forename: Edemilson Cardoso
authors.initials: EC
authors.lastname: da Conceição
keywords: Bergapten; coating; extrusion; photostability; psoralen