title: Central corneal thickness in primary angle closure and open angle glaucoma.
abstract: OBJECTIVE
  To quantitatively analyze central corneal thickness (CCT) in patients with primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG), and to evaluate its correlation with severity of glaucoma.
  
  
  METHODS
  In this retrospective study, records of patients with previously diagnosed POAG or PACG at a tertiary glaucoma service were reviewed. CCT was measured by ultrasound pachymetry. Mean deviation (MD) on visual field (VF) testing was recorded for glaucoma severity determination. CCT and age- and sex-adjusted CCT were compared among the study groups using Student's t-test and analysis of covariance (ANCOVA), respectively. Univariate and multivariate regression models were used for correlation of age, MD and CCT.
  
  
  RESULTS
  A total of 115 patients with PACG, 215 with POAG, and 100 normal controls were included with mean age of 64.1 ± 10.4, 59.9 ± 10.5, and 62.04 ± 10.80 years, respectively. CCT was thicker in PACG eyes (545.5 ± 46.1 μm) as compared to POAG eyes (531.7 ± 37.3 μm) and controls (531.0 ± 38.3 μm) even after age and gender adjustment (ANCOVA, P = 0.05). CCT was found to decrease with increasing age only in the POAG group (β = -0.57, P = 0.01). Disease severity (MD of VF) was significantly and inversely correlated with CCT in both POAG and PACG eyes (β = 1.89, P = 0.02; and β = 1.38, P = 0.04, respectively) after age and sex correction.
  
  
  CONCLUSIONS
  PACG eyes had thicker CCT as compared to POAG and normal healthy eyes in Iranian subjects. Severity of the disease was inversely correlated with CCT in eyes with both POAG and PACG.
authors.affiliation: Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran ; Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.affiliation: Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Torabi
authors.affiliation: Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Hesam
authors.initials: H
authors.lastname: Hashemian
authors.affiliation: Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Heydar
authors.initials: H
authors.lastname: Amini
authors.affiliation: Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Lin
keywords: Central Corneal Thickness; Primary Angle Closure Glaucoma; Primary Open-angle Glaucoma, Intraocular Pressure