title: Clonal and horizontal spread of the blaOXA-232 gene among Enterobacteriaceae in a Korean hospital.
abstract: All 16 Klebsiella pneumoniae isolates and both Escherichia coli isolates harbored the bla(OXA-232) and bla(CTX-M-15) genes. Furthermore, all 16 K. pneumoniae isolates belonged to a unique pulsed-field gel electrophoresis clone and were assigned to an identical sequence type (ST14). The 2 E. coli isolates were identified as ST131 and ST457. The bla(OXA-232) gene underwent horizontal transfer to E. coli isolates via a conjugative ColE-type plasmid. The introduction of this K. pneumoniae ST14 strain to the Korean hospital was attributed to an index patient who was likely colonized during a prior hospitalization in India.
authors.affiliation: Department of Laboratory Medicine and Research Institute for Antimicrobial Resistance, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Seok Hoon
authors.initials: SH
authors.lastname: Jeong
authors.affiliation: Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.
authors.forename: Kyu Man
authors.initials: KM
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.
authors.forename: Jacob
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Dental Hygiene, Silla University, Busan, Republic of Korea.
authors.forename: Il Kwon
authors.initials: IK
authors.lastname: Bae
authors.affiliation: Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.
authors.forename: Jae-Seok
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea.
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, Hallym University College of Medicine, Chuncheon, Republic of Korea. Electronic address: swonkeun@hallym.or.kr.
authors.forename: Wonkeun
authors.initials: W
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003227:Conjugation, Genetic; D003428:Cross Infection / Q000382:microbiology*; D016521:Electrophoresis, Gel, Pulsed-Field; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D022761:Gene Transfer, Horizontal; D005838:Genotype; D006761:Hospitals; D006801:Humans; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D058889:Molecular Typing; D010957:Plasmids / Q000032:analysis*; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001618:beta-Lactamases
keywords: ColE-type plasmid; Klebsiella pneumoniae ST14; OXA-232; OXA-48