title: Rhodium-catalyzed 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one derivatives.
abstract: 7-Azaindoles are versatile building blocks, especially in medicinal chemistry, where they serve as bioisosteres of indoles or purines. Herein, we present a novel rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-ones, as these substrates are exocyclic methylene lactamyl Michael acceptors. Ten new original derivatives of 1H-pyrrolo[2,3-b]pyridin-2(3H)-one have been obtained.
authors.affiliation: GICC UMR 7292, Equipe 4 "Innovation Moléculaire et Thérapeutique", Université de Tours, Labex SYNORG, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Croix
authors.affiliation: GICC UMR 7292, Equipe 4 "Innovation Moléculaire et Thérapeutique", Université de Tours, Labex SYNORG, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
authors.forename: Gildas
authors.initials: G
authors.lastname: Prié
authors.affiliation: GICC UMR 7292, Equipe 4 "Innovation Moléculaire et Thérapeutique", Université de Tours, Labex SYNORG, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Chaulet
authors.affiliation: GICC UMR 7292, Equipe 4 "Innovation Moléculaire et Thérapeutique", Université de Tours, Labex SYNORG, Faculté de Pharmacie, 31 avenue Monge, 37200 Tours, France.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Viaud-Massuard