title: Methacrylate micro/nano particles prepared by spray drying: a preliminary in vitro/in vivo study.
abstract: Delivery systems controlling drug release only in the colon holds great promises since they improve utilization of drug and decrease the dosing times comparison with conventional forms. The aim of the present study was to prepare polymeric microparticles on the basis of Ciprofloxacin via oral route for the treatment of inflammatory bowel disease. Ciprofloxacin was selected because of its extensive coverage for intestinal flora, relatively favorable side-effect profile and preliminary data suggesting its efficacy in the treatment of active Crohn's Disease. Microparticles were prepared using different acrylic compounds, namely Eudragit® RL (PO) and RS (PO) and a mixture of both. Spray-drying was used as a preparation method of Ciprofloxacin/Eudragit® microparticles using a Mini Spray Dryer B-290 (Büchi, Postfach, Switzerland). In vitro dissolution studies were performed to choose the best formulation and selected microparticles were characterized by size and morphology by environmental scanning electron microscopy. Yield and encapsulation efficiency were calculated and in vivo/ex vivo experiments were investigated both of which suggest that selected microparticles can be used for colon targeting of drugs increasing residence time of the drug in the affected area.
authors.affiliation: a Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy , Granada University , Granada , Spain and.
authors.forename: Begoña
authors.initials: B
authors.lastname: Muñoz Ortega
authors.affiliation: b Department of Industrial Pharmacy, Faculty of Pharmacy , Alexandria University , Alexandria , Egypt.
authors.forename: Marwa Ahmed
authors.initials: MA
authors.lastname: Sallam
authors.affiliation: a Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy , Granada University , Granada , Spain and.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Marín Boscá
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000284:Administration, Oral; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D003424:Crohn Disease / Q000188:drug therapy* / Q000378:metabolism; D003890:Desiccation; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility
chemical_list: D000180:Acrylic Resins; D005079:Excipients; D008689:Methacrylates; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D002939:Ciprofloxacin
keywords: Ciprofloxacin; Eudragit RL; Eudragit RS; colon delivery; microencapsulation; spray drying