title: [The role of necrosis and inflammation markers in prognostication of acute coronary heart disease].
abstract: With the incessant growth of cardiovascular mortality, mainly due to myocardial infarction makes prognostication of acute coronary syndrome a principal goal of clinical practice. Biochemical markers (creatine phosphokinase-MB and troponins) are extensively used for diagnostics and prediction of acute coronary heart syndrome (ACS). However, drawbacks of necrosis markers necessitate the search for new ones identifiable at early stages of atherosclerotic plaque instability. Lately atherosclerosis has been considered as an immuno-inflammatory reaction involving cytokines, chemokines, C-reactive protein, natriuretic peptide, and tumor necrosis factor-alpha. Their prognostic value has been demonstrated in many clinical studies, but these data are contradictory and need to be confirmed.
authors.forename: M A
authors.initials: MA
authors.lastname: Shalenkova
authors.forename: E T
authors.initials: ET
authors.lastname: Mukhametova
authors.forename: Z D
authors.initials: ZD
authors.lastname: Mikhailova
mesh_terms: D002097:C-Reactive Protein; D003327:Coronary Disease / Q000175:diagnosis*; D006801:Humans; D007378:Interleukins / Q000097:blood*; D045265:Natriuretic Peptides / Q000097:blood*; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D007378:Interleukins; D045265:Natriuretic Peptides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein