title: Evaluation of osseous integration of PVD-silver-coated hip prostheses in a canine model.
abstract: Infection associated with biomaterials used for orthopedic prostheses remains a serious complication in orthopedics, especially tumor surgery. Silver-coating of orthopedic (mega)prostheses proved its efficiency in reducing infections but has been limited to surface areas exposed to soft tissues due to concerns of silver inhibiting osseous integration of cementless stems. To close this gap in the bactericidal capacity of silver-coated orthopedic prostheses extension of the silver-coating on surface areas intended for osseous integration seems to be inevitable. Our study reports about a PVD- (physical-vapor-deposition-) silver-coated cementless stem in a canine model for the first time and showed osseous integration of a silver-coated titanium surface in vivo. Radiological, histological, and biomechanical analysis revealed a stable osseous integration of four of nine stems implanted. Silver trace elemental concentrations in serum did not exceed 1.82 parts per billion (ppb) and can be considered as nontoxic. Changes in liver and kidney functions associated with the silver-coating could be excluded by blood chemistry analysis. This was in accordance with very limited metal displacement from coated surfaces observed by laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) 12 months after implantation. In conclusion our results represent a step towards complete bactericidal silver-coating of orthopedic prostheses.
authors.affiliation: Department of Orthopedics and Tumor Orthopedics, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Gregor
authors.initials: G
authors.lastname: Hauschild
authors.affiliation: Department of Orthopedics and Tumor Orthopedics, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Jendrik
authors.initials: J
authors.lastname: Hardes
authors.affiliation: Department of Orthopedics and Tumor Orthopedics, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Gosheger
authors.affiliation: Department of General and Visceral Surgery, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Sandra
authors.identifier: 0000-0002-2498-6113
authors.initials: S
authors.lastname: Stoeppeler
authors.affiliation: Department of Orthopedics and Tumor Orthopedics, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Helmut
authors.identifier: 0000-0001-7398-3077
authors.initials: H
authors.lastname: Ahrens
authors.affiliation: Institute of Inorganic and Analytical Chemistry, University of Muenster, Corrensstraße 28/30, 48149 Muenster, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Blaske
authors.affiliation: Institute of Inorganic and Analytical Chemistry, University of Muenster, Corrensstraße 28/30, 48149 Muenster, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wehe
authors.affiliation: Institute of Inorganic and Analytical Chemistry, University of Muenster, Corrensstraße 28/30, 48149 Muenster, Germany.
authors.forename: Uwe
authors.initials: U
authors.lastname: Karst
authors.affiliation: Department of Orthopedics and Tumor Orthopedics, University Hospital of Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Höll
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004285:Dogs; D006622:Hip Prosthesis / Q000009:adverse effects* / Q000382:microbiology; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D018030:Silver Compounds / Q000494:pharmacology*; D014025:Titanium / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D018030:Silver Compounds; D014025:Titanium