title: DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.
abstract: A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor samples. We have identified driver genes in the genomic data of 34 tumor types derived from existing exploratory projects such as The Cancer Genome Atlas and from studies investigating the usefulness of genomic information in the clinical settings. DOTS-Finder is available at https://cgsb.genomics.iit.it/wiki/projects/DOTS-Finder/.
authors.affiliation: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, 20139 Milan, Italy.
authors.forename: Giorgio Em
authors.initials: GE
authors.lastname: Melloni
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.
authors.forename: Alessandro Ge
authors.initials: AG
authors.lastname: Ogier
authors.affiliation: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, 20139 Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: de Pretis
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Mazzarella
authors.affiliation: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, 20139 Milan, Italy.
authors.forename: Mattia
authors.initials: M
authors.lastname: Pelizzola
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy ; Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20122 Milan, Italy.
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: Pelicci
authors.affiliation: Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia, 20139 Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Riva