title: Postoperative oxycodone toxicity in a patient with chronic pain and end-stage renal disease.
abstract: We present this case to review the metabolism of oxycodone and the effects of end-stage renal disease on the elimination of oxycodone and its metabolites. A 42-year-old female with end-stage renal disease who was dependent on hemodialysis presented for left hamstring posterior capsule release. She had been receiving methadone for 2 years for chronic leg pain. On postoperative day 1, the patient's medication was changed from IV hydromorphone to oral oxycodone to treat breakthrough pain. By the next day, the patient was unarousable with notable respiratory depression. She did not fully recover after urgent hemodialysis but did have full recovery after receiving an IV naloxone infusion for 22 hours. Further study of the safety of oxycodone in hemodialysis patients is warranted.
authors.affiliation: From the Department of Anesthesiology, University of Virginia Medical Center, Charlottesville, Virginia.
authors.forename: Bryant W
authors.initials: BW
authors.lastname: Tran
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Kohan
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Vorenkamp
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D001711:Biotransformation; D059350:Chronic Pain / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D057913:Joint Capsule Release / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy*; D007866:Leg / Q000294:innervation* / Q000601:surgery*; D009270:Naloxone / Q000008:administration & dosage; D009292:Narcotic Antagonists / Q000008:administration & dosage; D010098:Oxycodone / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D006435:Renal Dialysis; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D009292:Narcotic Antagonists; D009270:Naloxone; D010098:Oxycodone