title: Consideration of evidence for therapeutic interventions in bovine polioencephalomalacia.
abstract: Randomized, masked, prospective clinical trial evidence for therapeutic intervention in naturally occurring bovine polioencephalomalacia (polio) is nonexistent. This article evaluates the use of thiamine and anti-inflammatories in the therapy of polioencephalomalacia based on available information related to the pathophysiology of the disease, induced models, disease outcome in other species (sheep), and parallels in similar disease in humans.
authors.affiliation: Department of Clinical Sciences, Kansas State University College of Veterinary Medicine, 1800 Denison Avenue, Manhattan, KS 66506, USA. Electronic address: mapley@vet.ksu.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Apley
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004678:Encephalomalacia / Q000188:drug therapy / Q000662:veterinary*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy
keywords: Bovine; Dexamethasone; Dimethyl sulfoxide; Furosemide; Mannitol; Nonsteroidal anti-inflammatory drugs; Polioencephalomalacia; Thiamine