title: Composite diffuse large B-cell lymphoma and follicular B-cell lymphoma - case report and review of literature.
abstract: Composite lymphoma refers to the co-occurrence of two or more morphologically and immunophenotypically separate lymphomas in the same topographic site at the time of clinical presentation. It is an infrequent type of lymphoid neoplasm, present in lymphoid tissue and may be due to the existence of two genetically related neoplasms such as transformation of a single lymphoma into another more aggressive lymphoma or be due to the presence of two clonally unrelated lymphomas. This paper is presenting a case of diffuse non-Hodgkin large B-cell lymphoma with areas of low grade and high grade follicular non-Hodgkin B-cell lymphoma in a retroperitoneal lymph node and spleen of an 62 year old woman. Histopathological examination and immunohistochemistry features proved the diagnosis of composite lymphoma.
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Turbatu
authors.affiliation: Department of Internal Medicine, "Dr. I.Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: Marilena
authors.initials: M
authors.lastname: Stoian
authors.affiliation: Department of General Surgery, "Dr.I.Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: Iulian
authors.initials: I
authors.lastname: Brezean
authors.affiliation: Department of Internal Medicine, "Dr. I.Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: Victor Constantin Ion
authors.initials: VC
authors.lastname: Stoica
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Andrei
authors.initials: A
authors.lastname: Colita
authors.affiliation: Department of Hematology, Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Camelia
authors.initials: C
authors.lastname: Dobrea
authors.affiliation: Department of Internal Medicine, "Dr. I.Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: Nicoleta
authors.initials: N
authors.lastname: State
authors.affiliation: Department of Internal Medicine, "Dr. I.Cantacuzino" Clinical Hospital, Bucharest, Romania.
authors.forename: Cosmin
authors.initials: C
authors.lastname: Ionescu
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Ana-Maria
authors.initials: AM
authors.lastname: Ivanescu
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Madalina
authors.initials: M
authors.lastname: Oprea
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ghimici
authors.affiliation: Department of Hematology, Coltea Clinical Hospital, Bucharest, Romania.
authors.forename: Anca Roxana
authors.initials: AR
authors.lastname: Lupu
keywords: ascites; composite lymphoma; diffuse large B-cell lymphoma; low grade follicular lymphoma