title: Ion-pair amphiphile: a neoteric substitute that modulates the physicochemical properties of biomimetic membranes.
abstract: Ion-pair amphiphiles (IPAs) are neoteric pseudo-double-tailed compounds with potential as a novel substitute of phospholipid. IPA, synthesized by stoichiometric/equimolar mixing of aqueous solution of hexadecyltrimethylammonium bromide (HTMAB) and sodium dodecyl sulfate (SDS), was used as a potential substituent of naturally occurring phospholipid, soylecithin (SLC). Vesicles were prepared using SLC and IPA in different ratios along with cholesterol. The impact of IPA on SLC was examined by way of surface pressure (π)-area (A) measurements. Associated thermodynamic parameters were evaluated; interfacial miscibility between the components was found to depend on SLC/IPA ratio. Solution behavior of the bilayers, in the form of vesicles, was investigated by monitoring the hydrodynamic diameter, zeta potential, and polydispersity index over a period of 100 days. Size and morphology of the vesicles were also investigated by electron microscopic studies. Systems comprising 20 and 40 mol % IPA exhibited anomalous behavior. Thermal behavior of the vesicles, as scrutinized by differential scanning calorimetry, was correlated with the hydrocarbon chain as well as the headgroup packing. Entrapment efficiency (EE) of the vesicles toward the cationic dye methylene blue (MB) was also evaluated. Vesicles were smart enough to entrap the dye, and the efficiency was found to vary with IPA concentration. EE was found to be well above 80% for some stable dispersions. Such formulations thus could be considered to have potential as novel drug delivery systems.
authors.affiliation: †Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India.
authors.forename: Pritam
authors.initials: P
authors.lastname: Guha
authors.affiliation: †Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India.
authors.forename: Biplab
authors.initials: B
authors.lastname: Roy
authors.affiliation: †Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India.
authors.forename: Gourab
authors.initials: G
authors.lastname: Karmakar
authors.affiliation: †Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India.
authors.forename: Prasant
authors.initials: P
authors.lastname: Nahak
authors.affiliation: ‡Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India.
authors.forename: Suraj
authors.initials: S
authors.lastname: Koirala
authors.affiliation: ‡Department of Pharmaceutics, Himalayan Pharmacy Institute, Majhitar, Rangpo, East Sikkim 737136, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Sapkota
authors.affiliation: §Department of Pure and Applied Chemistry, Tokyo University of Science, 2641 Yamazaki, Noda, Tokyo 278-8510, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Misono
authors.affiliation: §Department of Pure and Applied Chemistry, Tokyo University of Science, 2641 Yamazaki, Noda, Tokyo 278-8510, Japan.
authors.forename: Kanjiro
authors.initials: K
authors.lastname: Torigoe
authors.affiliation: †Department of Chemistry, University of North Bengal, Darjeeling 734 013, West Bengal, India.
authors.forename: Amiya Kumar
authors.initials: AK
authors.lastname: Panda
mesh_terms: D000388:Air; D040761:Biomimetic Materials / Q000737:chemistry*; D002021:Buffers; D002784:Cholesterol / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D057446:Hydrodynamics; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D054709:Lecithins / Q000737:chemistry; D008567:Membranes, Artificial; D008751:Methylene Blue / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011312:Pressure; D013025:Glycine max / Q000737:chemistry
chemical_list: D002021:Buffers; D004337:Drug Carriers; D054709:Lecithins; D008567:Membranes, Artificial; D002784:Cholesterol; D008751:Methylene Blue