title: Disease burden in Brazil: an investigation into alcohol and non-viral cirrhosis.
abstract: Alcohol use/dependence are an important risk factor for cirrhosis of the liver. The article aims to describe and conduct a comparative analysis of Disability Adjusted Life Years (DALY), Years of Life Lost (YLL) and Years Lived with Disability (YLD) of alcohol use disorders and non-viral cirrhosis in Brazil in 2008. DALY was calculated as the sum of YLL and YLD. For YLL estimates, the mean number of deaths from 2007- 2009 in the country was considered. After revision of epidemiological data, prevalence of each disease was modelled with the DisMod tool, which generated incidence data for YLD estimates. Alcohol and non-viral cirrhosis were responsible for 3% and 1% of total DALYs, respectively. In both diseases, men contributed to a greater proportion of DALYs. Among the first ten causes of DALYs, alcohol use disorders occupied the second, third and sixth positions at the ages of 15-29, 30-44 and 45- 59, respectively. Non-viral cirrhosis was the eighth cause of DALY in the 30-44 age group in men; the fifth, in the 45-59 group and the eighth, in the 60-69 group. Age distribution suggests that interventions directed against alcohol use/dependence would have effects on the burden of alcoholic cirrhosis in the country.
authors.affiliation: Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brasil, flaviabportugal@gmail.com.
authors.forename: Flávia Batista
authors.initials: FB
authors.lastname: Portugal
authors.affiliation: Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brasil, flaviabportugal@gmail.com.
authors.forename: Mônica Rodrigues
authors.initials: MR
authors.lastname: Campos
authors.affiliation: Serviço de Pronto Atendimento, Hospital do Câncer, Instituto Nacional do Câncer.
authors.forename: Juliana Ribeiro
authors.initials: JR
authors.lastname: de Carvalho
authors.affiliation: Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brasil, flaviabportugal@gmail.com.
authors.forename: Luisa Sório
authors.initials: LS
authors.lastname: Flor
authors.affiliation: Escola Nacional de Saúde Pública, Fiocruz, Rio de Janeiro, RJ, Brasil, flaviabportugal@gmail.com.
authors.forename: Joyce Mendes de Andrade
authors.initials: JM
authors.lastname: Schramm
authors.affiliation: Departamento de Informação e Documentação, Instituto Fernandes Figueira, Fiocruz.
authors.forename: Maria de Fátima dos Santos
authors.initials: Mde F
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000453:epidemiology*; D001938:Brazil; D017281:Cost of Illness; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D055815:Young Adult