title: [Progresses in predicting the crystallizability of proteins].
abstract: Determination of protein 3-dimensional structure offers very important information in biology researches, especially for understanding protein functions and redundant drug design. The X-ray crystallography is still the main technique for protein structure determination. Obtaining protein crystals is an essential procedure after protein purification in this technique. However, there is only 42% of soluble purified proteins yield crystals by statistics. Experimental verification of protein crystallizability is relatively expensive and time-consuming. Thus it is desired to predict the protein crystallizability by a computational method before starting the experiment. In this paper, combined with our own efforts, some successful in silico methods to predict the protein crystallizability are reviewed.
authors.forename: Renbin
authors.initials: R
authors.lastname: Zhou
authors.forename: Huimeng
authors.initials: H
authors.lastname: Lu
authors.forename: Dachuan
authors.initials: D
authors.lastname: Yin
mesh_terms: D003460:Crystallization / Q000379:methods*; D018360:Crystallography, X-Ray; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins