title: Sex-dependent effects of nutrition on telomere dynamics in zebra finches (Taeniopygia guttata).
abstract: At a cellular level, oxidative stress is known to increase telomere attrition, and hence cellular senescence and risk of disease. It has been proposed that dietary micronutrients play an important role in telomere protection due to their antioxidant properties. We experimentally manipulated dietary micronutrients during early life in zebra finches (Taeniopygia guttata). We found no effects of micronutrient intake on telomere loss during chick growth. However, females given a diet high in micronutrients during sexual maturation showed reduced telomere loss; there was no such effect in males. These results suggest that micronutrients may influence rates of cellular senescence, but differences in micronutrient requirement and allocation strategies, probably linked to the development of sexual coloration, may underlie sex differences in response.
authors.affiliation: Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK jose.noguera@glasgow.ac.uk.
authors.forename: Jose C
authors.initials: JC
authors.lastname: Noguera
authors.affiliation: Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Neil B
authors.initials: NB
authors.lastname: Metcalfe
authors.affiliation: Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Winnie
authors.initials: W
authors.lastname: Boner
authors.affiliation: Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Pat
authors.initials: P
authors.lastname: Monaghan
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D004032:Diet; D005260:Female; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage* / Q000172:deficiency; D009752:Nutritional Status / Q000235:genetics / Q000502:physiology*; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D012727:Sex Characteristics; D012741:Sexual Maturation / Q000502:physiology; D020308:Songbirds / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D016615:Telomere / Q000502:physiology
chemical_list: D000975:Antioxidants; D018977:Micronutrients
keywords: ageing; antioxidants; diet; oxidative stress; sexual maturation