title: New clerodane diterpenoids from the twigs and leaves of Croton euryphyllus.
abstract: Three new nor-clerodane diterpenoids, crotoeurins A-C (1-3), together with four known ones were isolated from the twigs and leaves of Croton euryphyllus. Among them, crotoeurin A (1) is a new nor-clerodane diterpenoid dimer with a unique cyclobutane ring via a [2+2] cycloaddition. Their structures were elucidated by spectroscopic analyses and the stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1-3 exhibited neurite outgrowth-promoting activity on NGF-mediated PC12 cells at concentration of 10μM.
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China. Electronic address: pan7260@126.com.
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
authors.forename: Desheng
authors.initials: D
authors.lastname: Ning
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, PR China.
authors.forename: Xingde
authors.initials: X
authors.lastname: Wu
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Huang
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
authors.forename: Dianpeng
authors.initials: D
authors.lastname: Li
authors.affiliation: Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, PR China.
authors.forename: Shihong
authors.initials: S
authors.lastname: Lv
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D029802:Croton / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D020932:Nerve Growth Factor / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D016716:PC12 Cells; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D051381:Rats
chemical_list: D045785:Diterpenes, Clerodane; D020932:Nerve Growth Factor
keywords: Crotoeurins A–C; Croton euryphyllus; Neurite outgrowth-promoting activity; Nor-clerodane diterpenoid