title: The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes.
abstract: Objectives. To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 diabetes and (2) the association between IntraMAT and mobility and strength. Methods. 59 women ≥ 65 years with and without type 2 diabetes were included. A 1-Tesla MRI was used to acquire images of the leg. Timed-up-and-go (TUG) and grip strength were measured. Regression was used to determine associations between the following: (1) type 2 diabetes and IntraMAT (covariates: age, ethnicity, BMI, waist : hip ratio, and energy expenditure), (2) IntraMAT and TUG (covariates: diabetes, age, BMI, and energy expenditure), and (3) IntraMAT and grip strength (covariates: diabetes, age, height, and lean mass). Results. Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups (diabetes mean [SD] = 13.2 [1.4]%, controls 11.8 [1.3]%, P = 0.515). IntraMAT was related to TUG and grip strength, but the relationships became nonsignificant after adjustment for covariates (difference/percent IntraMAT [95% CI]: TUG = 0.041 seconds [-0.079-0.161], P = 0.498, grip strength = -0.144 kg [-0.335-0.066], P = 0.175). Conclusions. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored.
authors.affiliation: Geriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter's Hospital, 88 Maplewood Avenue, Hamilton, ON, Canada L8M 1W9 ; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Pritchard
authors.affiliation: Geriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter's Hospital, 88 Maplewood Avenue, Hamilton, ON, Canada L8M 1W9 ; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Sarah
authors.identifier: 0000-0003-0594-6009
authors.initials: S
authors.lastname: Karampatos
authors.affiliation: Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; Charlton Medical Centre, 25 Charlton Avenue East, Hamilton, ON, Canada L8N 1Y2.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Beattie
authors.affiliation: Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1.
authors.forename: Lora M
authors.initials: LM
authors.lastname: Giangregorio
authors.affiliation: Geriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter's Hospital, 88 Maplewood Avenue, Hamilton, ON, Canada L8M 1W9 ; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; Charlton Medical Centre, 25 Charlton Avenue East, Hamilton, ON, Canada L8N 1Y2.
authors.forename: George
authors.initials: G
authors.lastname: Ioannidis
authors.affiliation: Department of Pediatrics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Atkinson
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Lehana
authors.initials: L
authors.lastname: Thabane
authors.affiliation: Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Hertzel
authors.initials: H
authors.lastname: Gerstein
authors.affiliation: Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Zubin
authors.initials: Z
authors.lastname: Punthakee
authors.affiliation: Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1 ; Charlton Medical Centre, 25 Charlton Avenue East, Hamilton, ON, Canada L8N 1Y2.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Adachi
authors.affiliation: Geriatric Education and Research in Aging Sciences (GERAS) Centre, St. Peter's Hospital, 88 Maplewood Avenue, Hamilton, ON, Canada L8M 1W9 ; Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papaioannou