title: Effect of three different bariatric obesity surgery procedures on nutrient and energy digestibility using a swine experimental model.
abstract: Morbid obesity is a worldwide health concern that compromises life quality and health status of obese human subjects. Bariatric surgery for treating morbid obesity remains as one of the best alternatives to promote excess weight loss and to reduce co-morbidities. We have not found studies reporting nutrients and energy balance considering digestibility trials in humans following surgery. The purpose of this study was to determine protein, lipid, fiber, energy, calcium, and phosphorous digestibility in a swine model that underwent ileal transposition (IT), sleeve gastrectomy with ileal transposition (SGIT), Roux-en-Y gastric bypass (RYGBP), and with sham operated animals (SHAM). Thirty-two pigs were randomly assigned to four laparoscopic procedures: IT (n = 8), RYGBP (n = 8), SGIT (n = 8), and Sham-operated pigs (n = 8). From day 0 postsurgery to 130, pigs were weighed monthly to determine live weight and weight gain was calculated for each month postsurgery until day 130. Food intake in a metabolic weight basis was calculated by measuring ad libitum food intake at day 130. Swine were fitted into metabolic crates to determine digestibility coefficients of dry matter, protein, fat, fiber, ash, energy, calcium, and phosphorous from day 130. A one-way ANOVA and Student-Newman-Keuls were used to detect differences in weight, food intake, and digestibility coefficients. Digestibility values for dry matter, fiber, phosphorus, and energy showed no differences among groups (P > 0.05). However, significant differences (P ≤ 0.05) were encountered among groups for fat, protein, ash, and calcium digestibilities. The RYGBP procedure, when applied to the pig model, significantly reduced calcium, fat, and ash digestibility, which did not occur with SGIT or IT procedure, when compared with Sham-operated animals.
authors.affiliation: Animal Sciences Department, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile, P.O. Box 6904411 mgandari@uc.cl.
authors.forename: Mónica
authors.initials: M
authors.lastname: Gandarillas
authors.affiliation: Instituto de Producción Animal, Facultad de Ciencias Agrarias, Universidad Austral de Chile, Casilla 567, Valdivia, Chile, P.O. Box 5090000.
authors.forename: Suzanne Marie
authors.initials: SM
authors.lastname: Hodgkinson
authors.affiliation: Animal Sciences Department, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile, P.O. Box 6904411.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Riveros
authors.affiliation: Animal Sciences Department, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile, P.O. Box 6904411.
authors.forename: Fernando
authors.initials: F
authors.lastname: Bas
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D050110:Bariatric Surgery / Q000009:adverse effects / Q000379:methods*; D004063:Digestion; D004435:Eating; D005743:Gastrectomy / Q000009:adverse effects / Q000379:methods; D015390:Gastric Bypass / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007581:Jejunoileal Bypass / Q000009:adverse effects / Q000379:methods; D008286:Malabsorption Syndromes / Q000503:physiopathology; D008297:Male; D023421:Models, Animal; D009767:Obesity, Morbid / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D034421:Sus scrofa / Q000502:physiology / Q000601:surgery
keywords: Swine; animal model; bariatric surgery; digestibility