title: A TagSNP in SIRT1 gene confers susceptibility to myocardial infarction in a Chinese Han population.
abstract: SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the effects of SIRT1 variants on MI risk remain poorly understood. Here we aimed to investigate the influence of SIRT1 polymorphisms on individual susceptibility to MI. Genotyping of three tagSNPs (rs7069102, rs3818292 and rs4746720) in SIRT1 gene was performed in a Chinese Han population, consisting of 287 MI cases and 654 control subjects. In a logistic regression analysis, we found that G allele of rs7069102 had increased MI risk with odds ratio (OR) of 1.57 [95% confidence interval (CI) = 1.15-2.16, Bonferroni corrected P (Pc) = 0.015] after adjustment for conventional risk factors compared to C allele. Similarly, the combined CG/GG genotypes was associated with the increased MI risk (OR = 1.64, 95% CI = 1.14-2.35, Pc = 0.021) compared to the CC genotype. Further stratified analysis revealed a more significant association with MI risk among younger subjects (≤ 55 years old). Consistent with these results, the haplotype rs7069102G-rs3818292A-rs4746720T containing the rs7069102 G allele was also associated with the increased MI risk (OR = 1.41, 95% CI = 1.09-1.84, Pc = 0.040). However, we did not detect any association of rs3818292 and rs4746720 with MI risk. Our study provides the first evidence that the tagSNP rs7069102 and haplotype rs7069102G-rs3818292A-rs4746720T in SIRT1 gene confer susceptibility to MI in the Chinese Han population.
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America.
authors.forename: Miook
authors.initials: M
authors.lastname: Cho
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, P.R. China.
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Cen
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China.
authors.forename: Meng-yun
authors.initials: MY
authors.lastname: Cai
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China.
authors.forename: Shun
authors.initials: S
authors.lastname: Xu
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China.
authors.forename: Ze-wei
authors.initials: ZW
authors.lastname: Ma
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, P.R. China.
authors.forename: Xinguang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Disease, The First People's Hospital of Foshan, Foshan, P.R. China.
authors.forename: Xi-li
authors.initials: XL
authors.lastname: Yang
authors.affiliation: Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, P.R. China.
authors.forename: Can
authors.initials: C
authors.lastname: Chen
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, United States of America.
authors.forename: Yousin
authors.initials: Y
authors.lastname: Suh
authors.affiliation: Institute of Aging Research, Guangdong Medical College, Dongguan, P.R. China; Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan, P.R. China; Institute of Biochemistry & Molecular Biology, Guangdong Medical College, Zhanjiang, P.R. China.
authors.forename: Xing-dong
authors.initials: XD
authors.lastname: Xiong
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*
chemical_list: C447939:SIRT1 protein, human; D056564:Sirtuin 1