title: Preparation and evaluation of novel octylmethoxycinnamate-loaded solid lipid nanoparticles.
abstract: OBJECTIVE
  Octylmethoxycinnamate (OMC)-loaded solid lipid nanoparticles (SLNs) were prepared by ultrasonic emulsification method. Effects of process variables and formulation composition were investigated on particle size and polydispersity index (PI), and the UV absorbance. Effect of OMC concentration on entrapment efficiency (EE) was also studied.
  
  
  METHODS
  The optimal formulation was characterized and evaluated by environment emission scanning electron microscopy (ESEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). In addition, the degradations of OMC from SLNs and OMC conventional emulsion were compared.
  
  
  RESULTS
  The composition of optimal formulation was determined as 5% (w/w) of solid lipid, 7% (w/w) of emulsifier and 9% of loaded OMC, resulting in a particle size of 392.8 nm, and EE of 88.73%, LD of 38.05% under the preparation condition of 6 min of sonication, 400 W of sonication power. ESEM study showed spherical particles with smooth surface. DSC studies indicated OMC encapsulation within the nanoparticle matrix. The characteristic peaks for OMC-SLNs stood at 1710, 1604, 1513, 1465 and 830.3 cm(-1) . The degradation rate of OMC was decreased when using SLNs formulations compared to conventional emulsion.
  
  
  CONCLUSIONS
  Hence, the developed SLNs can be used as sunscreen carrier for improve the stability.
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100, Haiquan Road, Fengxian District, Shanghai, 201418, China.
authors.forename: X-h
authors.initials: XH
authors.lastname: Liu
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100, Haiquan Road, Fengxian District, Shanghai, 201418, China.
authors.forename: X-z
authors.initials: XZ
authors.lastname: Liang
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100, Haiquan Road, Fengxian District, Shanghai, 201418, China.
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.affiliation: School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100, Haiquan Road, Fengxian District, Shanghai, 201418, China.
authors.forename: W-P
authors.initials: WP
authors.lastname: Zhang
mesh_terms: D002152:Calorimetry, Differential Scanning; D002934:Cinnamates / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002934:Cinnamates; D008055:Lipids; C118580:octylmethoxycinnamate
keywords: characterization; differential scanning calorimetry; emulsions; octylmethoxycinnamate; solid lipid nanoparticles; spectroscopy; stability