title: NF-κB in cancer therapy.
abstract: The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regulated genes have been linked to malignant transformation, tumor cell proliferation, survival, angiogenesis, invasion/metastasis, and therapeutic resistance. In this review, we highlight the diverse molecular mechanism(s) by which the NF-κB pathway is constitutively activated in different types of human cancers, and the potential role of various oncogenic genes regulated by this transcription factor in cancer development and progression. Additionally, various pharmacological approaches employed to target the deregulated NF-κB signaling pathway, and their possible therapeutic potential in cancer therapy is also discussed briefly.
authors.affiliation: Department of Pharmacology, Yong Loo Lin School of Medicine, Cancer Science Institute, National University of Singapore, Singapore, 117597, Singapore.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jingwen
authors.initials: J
authors.lastname: Zhang
authors.forename: Frank
authors.initials: F
authors.lastname: Arfuso
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Chinnathambi
authors.forename: M E
authors.initials: ME
authors.lastname: Zayed
authors.forename: Sulaiman Ali
authors.initials: SA
authors.lastname: Alharbi
authors.forename: Alan Prem
authors.initials: AP
authors.lastname: Kumar
authors.forename: Kwang Seok
authors.initials: KS
authors.lastname: Ahn
authors.forename: Gautam
authors.initials: G
authors.lastname: Sethi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016328:NF-kappa B / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B