title: Strategy for the management of diabetic macular edema: the European vitreo-retinal society macular edema study.
abstract: OBJECTIVE
  To compare the efficacy of different therapies in the treatment of diabetic macular edema (DME).
  
  
  METHODS
  Nonrandomized, multicenter clinical study.
  
  
  METHODS
  86 retina specialists from 29 countries provided clinical information on 2,603 patients with macular edema including 870 patients with DME.
  
  
  METHODS
  Reported data included the type and number of treatment(s) performed, the pre- and posttreatment visual acuities, and other clinical findings. The results were analyzed by the French INSEE (National Institute of Statistics and Economic Studies).
  
  
  METHODS
  Mean change of visual acuity and mean number of treatments performed.
  
  
  RESULTS
  The change in visual acuity over time in response to each treatment was plotted in second order polynomial regression trend lines. Intravitreal triamcinolone monotherapy resulted in some improvement in vision. Treatment with threshold or subthreshold grid laser also resulted in minimal vision gain. Anti-VEGF therapy resulted in more significant visual improvement. Treatment with pars plana vitrectomy and internal limiting membrane (ILM) peeling alone resulted in an improvement in vision greater than that observed with anti-VEGF injection alone. In our DME study, treatment with vitrectomy and ILM peeling alone resulted in the better visual improvement compared to other therapies.
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Ron
authors.initials: R
authors.lastname: Adelman
authors.affiliation: Eyecare Medical Group, Portland, ME, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Parnes
authors.affiliation: Ophthalmic Clinic "Jasne Blonia", Lodz, Poland.
authors.forename: Zofia
authors.identifier: 0000-0001-8376-9218
authors.initials: Z
authors.lastname: Michalewska
authors.affiliation: Department of Ophthalmology, S. Anna Hospital, Brescia, Italy.
authors.forename: Barbara
authors.identifier: 0000-0002-7838-6834
authors.initials: B
authors.lastname: Parolini
authors.affiliation: American Hospital of Paris, Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Boscher
authors.affiliation: EVRS, Nantes, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Ducournau
mesh_terms: D001485:Basement Membrane / Q000473:pathology; D003930:Diabetic Retinopathy / Q000473:pathology / Q000628:therapy*; D019468:Disease Management; D006801:Humans; D008269:Macular Edema / Q000473:pathology / Q000628:therapy*; D012160:Retina / Q000473:pathology; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy / Q000379:methods