title: [Mutagenic activation and carcinogenicity of aminoazo dyes of ortho-aminoazotoluene and 3'-methyl-4-dimethylaminoazobenzene in experiments on suckling mice].
abstract: It is found that after administration of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB,) which was hepatocarcinogenic to rats, in suckling mice, the number of neoplastic lesions in the liver of mice was 3 times higher than after analogous administration of equimolar dose of ortho-aminoazotoluene (OAT)). However, in the Ames test (TA-98 strain of Salmonella typhimurium) with activation by hepatic enzymes (S-9 fraction) of both intact and Aroclor-1254-induced mice and rats OAT contributed by an order of magnitude to revertant colonies compared to 3'-Me-DAB. In vivo inhibition of sulfotransferase activity, the enzyme which catalyzes the final stage of the mutagenic activation of aminoazo dyes, had no effect on carcinogenicity of 3'-Me-DAB but more than 4 times elevated that of OAT. It was concluded that the mechanism of carcinogenic action of aminoazo dyes studied is not genotoxic and that the carcinogenic potential of OAT is lost in the process of mutagenic activation.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: S I
authors.initials: SI
authors.lastname: Il'nitskaia
authors.forename: L P
authors.initials: LP
authors.lastname: Ovchinnikova
authors.forename: N A
authors.initials: NA
authors.lastname: Popova
authors.forename: L A
authors.initials: LA
authors.lastname: Bogdanova
authors.forename: T S
authors.initials: TS
authors.lastname: Morozkova
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology / Q000633:toxicity*; D004396:Coloring Agents / Q000494:pharmacology / Q000633:toxicity*; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D008749:Methyldimethylaminoazobenzene / Q000494:pharmacology / Q000633:toxicity*; D051379:Mice; D008808:Mice, Inbred CBA; D008813:Mice, Inbred ICR; D009153:Mutagens / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism; D009762:o-Aminoazotoluene / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D004396:Coloring Agents; D009153:Mutagens; D008749:Methyldimethylaminoazobenzene; D009762:o-Aminoazotoluene