title: [The role of cytokines in the development and clinical course of cardiac insufficiency].
abstract: The review is focused on the main premises of the theory of progressive cardiac insufficiency based on the notion of immune activation and systemic inflammation as markers of adverse prognosis and high risk of cardiovascular complications. The relationship between blood cytokine level/composition and severity of cardiac insufficiency is illustrated. Classification of cytokines is considered along with possible causes of their increased concentration and involvement in the development and clinical course of this condition. Special attention is given to the studies of methods for the correction of enhanced cytokine levels. The importance of further studies on the influence of cytokines on the clinical course of cardiac insufficiency is emphasized.
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Kravchenko
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Cherniaeva
mesh_terms: D016207:Cytokines / Q000276:immunology*; D006333:Heart Failure / Q000276:immunology*; D006801:Humans
chemical_list: D016207:Cytokines