title: Comparative study of hemodynamic changes caused by diazepam and midazolam during third molar surgery: a randomized controlled trial.
abstract: The aim of the present study was to compare hemodynamic changes using midazolam 7.5 mg and diazepam 10.0 mg during the surgical removal of symmetrically positioned third molars. A prospective, randomized, double-blind, clinical trial was carried out involving 120 patients divided into three groups: Group 1 (diazepam and placebo), Group 2 (midazolam and placebo), and Group 3 (diazepam and midazolam). Each subject underwent two surgeries on separate occasions under local anesthesia. The following parameters were assessed at five different times (T0, T1, T2, T3, and T4): systolic, diastolic, and mean blood pressure (SBP, DBP, and MBP, respectively); heart rate (HR); oxygen saturation (SpO(2)); rate pressure product (RPP); and pressure rate quotient (PRQ). Statistically significant differences were found regarding heart rate at T2 and T3 (p < 0.005) in Group 2, with a higher rate occurring during midazolam administration. Moreover, significant differences in rate pressure product were found at T2, T3, and T4 in this group, with higher values also occurring during midazolam administration. In Group 3, significant differences in diastolic blood pressure were found at T3 and T4, with higher values occurring during diazepam administration, whereas a higher heart rate occurred at T3 with midazolam. Midazolam 7.5 mg and diazepam 10.0 mg exert an influence on some hemodynamic parameters without perceptible clinical changes in healthy patients undergoing lower third molar surgery.
authors.affiliation: Oral and Maxillofacial Department, Dental School of Pernambuco, University of Pernambuco, Av. General Newton Cavalcanti, 1650 Tabatinga, Camaragibe, Pernambuco, 54.756-220, Brazil.
authors.forename: Hécio Henrique Araújo
authors.initials: HH
authors.lastname: de Morais
authors.forename: Jimmy Charles Melo
authors.initials: JC
authors.lastname: Barbalho
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: de Holanda Vasconcellos
authors.forename: Fabricio Souza
authors.initials: FS
authors.lastname: Landim
authors.forename: Fábio Andrey
authors.initials: FA
authors.lastname: da Costa Araújo
authors.forename: Tasiana Guedes
authors.initials: TG
authors.lastname: de Souza Dias
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental; D016854:Dental Anxiety / Q000188:drug therapy* / Q000523:psychology; D003975:Diazepam; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008874:Midazolam; D008964:Molar, Third / Q000601:surgery*; D010865:Pilot Projects; D014081:Tooth Extraction / Q000523:psychology*; D055815:Young Adult
chemical_list: D003975:Diazepam; D008874:Midazolam