title: [Reference values for blood coagulation factor activity in the Mexican population].
abstract: BACKGROUND
  During the fluid phase of hemostasis, fibrinogen is converted into fibrin, but other hemostatic factors are required. Reference values of hemostatic factors are established by manufacturers producing reagents using individuals with a specific genetic background.
  
  
  OBJECTIVE
  To establish reference values for hemostatic factors in the Mexican indigenous and Mestizo populations.
  
  
  METHODS
  We carried out a cross-sectional, descriptive study of healthy adult Mexicans. Clotting activity was evaluated using coagulometric assays. Blood donors were informed about the nature of the study and informed consent was obtained prior to blood being drawn. The protocol was approved by the Ethics Committee of our institution.
  
  
  RESULTS
  One hundred and twenty samples were assayed (60 females and 60 males). Fibrinogen was higher in mestizos and in females. Reference values for factor XII ranged from 40-170% in indigenous subjects and from 36-159% in mestizos. Factor VIII ranged from 57-160% in indigenous subjects and from 51-209% in mestizo subjects. Reference values for the other hemostatic factors were also clearly different from the commercial reference values. Reference values for hemostatic factors in the Mexican population are different from traditionally used commercial reference values. There were significant differences between indigenous and mestizo Mexicans in the concentration of hemostatic factors with a tendency among mestizos to have higher factor concentrations. Low levels of plasma factor XII are frequent and perhaps may represent a risk factor for thrombotic events. Using these reference values may individualize the reposition of factors in Mexican hemophiliac patients.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernández-Juárez
authors.forename: Manuel
authors.initials: M
authors.lastname: Moreno-Hernández
authors.forename: Tania
authors.initials: T
authors.lastname: Ricardo-Moreno
authors.forename: América
authors.initials: A
authors.lastname: García-González
authors.forename: Ethel A
authors.initials: EA
authors.lastname: García-Latorre
authors.forename: José Rubicel
authors.initials: JR
authors.lastname: Hernández-López
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ramírez-San Juan
authors.forename: Antonio
authors.initials: A
authors.lastname: Alvarado-Moreno
authors.forename: Irma
authors.initials: I
authors.lastname: Isordia-Salas
authors.affiliation: Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, IMSS.
authors.forename: Abraham
authors.initials: A
authors.lastname: Majluf-Cruz
mesh_terms: D000328:Adult; D001779:Blood Coagulation Factors / Q000502:physiology*; D001780:Blood Coagulation Tests; D001782:Blood Donors; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005169:Factor VIII / Q000502:physiology; D005174:Factor XII / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000502:physiology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008800:Mexico; D012016:Reference Values
chemical_list: D001779:Blood Coagulation Factors; D005169:Factor VIII; D005174:Factor XII; D005340:Fibrinogen