title: An efficient synthesis of quinolines via copper-catalyzed C-N cleavage.
abstract: An efficient method to synthesize substituted quinolines from ketones and 2-amino benzylamines is described. Copper-catalyzed C-N cleavage of amines followed by condensation with ketones deliver quinolines in moderate to high yields. The broad scope of substrates and the use of air as the sole oxidant make this transformation very attractive.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China. chensy@scu.edu.cn xqyu@scu.edu.cn.
authors.forename: Long-Yi
authors.initials: LY
authors.lastname: Xi
authors.forename: Ruo-Yi
authors.initials: RY
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Shan-Yong
authors.initials: SY
authors.lastname: Chen
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Yu
mesh_terms: D001596:Benzylamines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D011804:Quinolines; D002244:Carbon; D003300:Copper; C030796:benzylamine; D009584:Nitrogen