title: Risk factors for death from invasive pneumococcal disease, Europe, 2010.
abstract: We studied the possible association between patient age and sex, clinical presentation, Streptococcus pneumoniae serotype, antimicrobial resistance, and death in invasive pneumococcal disease cases reported by 17 European countries during 2010. The study sample comprised 2,921 patients, of whom 56.8% were men and 38.2% were >65 years of age. Meningitis occurred in 18.5% of cases. Death was reported in 264 (9.0%) cases. Older age, meningitis, and nonsusceptibility to penicillin were significantly associated with death. Non-pneumococcal conjugate vaccine (PCV) serotypes among children <5 years of age and 7-valent PCV serotypes among persons 5-64 years of age were associated with increased risk for death; among adults >65 years of age, risk did not differ by serotype. These findings highlight differences in case-fatality rates between serotypes and age; thus, continued epidemiologic surveillance across all ages is crucial to monitor the long-term effects of PCVs.
authors.forename: Adoración
authors.initials: A
authors.lastname: Navarro-Torné
authors.forename: Joana Gomes
authors.initials: JG
authors.lastname: Dias
authors.forename: Frantiska
authors.initials: F
authors.lastname: Hruba
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Lopalco
authors.forename: Lucia
authors.initials: L
authors.lastname: Pastore-Celentano
authors.forename: Andrew J Amato
authors.initials: AJ
authors.lastname: Gauci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D005060:Europe / Q000453:epidemiology; D005260:Female; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009026:Mortality; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000266:history / Q000517:prevention & control; D022242:Pneumococcal Vaccines; D011159:Population Surveillance; D012307:Risk Factors; D065288:Serogroup; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D022242:Pneumococcal Vaccines