title: Juvenile polymyositis associated with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody in a 13-year-old girl.
abstract: A 13-year-old girl was admitted for persistent thigh pain and remittent fever and was diagnosed as having juvenile polymyositis. Although the initial treatment with 2 cycles of methylprednisolone pulse therapy failed to achieve full remission, the second-line treatment with intravenous cyclophosphamide pulse therapy was effective. Anti-OJ antibody, which is one of anti-aminoacyl-tRNA synthetase (ARS) antibodies and is rare in adult polymyositis, was detected. Assessment of anti-ARS autoantibodies may facilitate diagnosis and management of juvenile polymyositis.
authors.affiliation: a Department of Pediatrics , Yao Municipal Hospital , Osaka , Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hamada
authors.affiliation: a Department of Pediatrics , Yao Municipal Hospital , Osaka , Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tanaka
authors.affiliation: b Department of Pediatrics , Matsubara Tokushukai Hospital , Osaka , Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: c Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hosono
authors.affiliation: c Department of Rheumatology and Clinical Immunology , Graduate School of Medicine, Kyoto University , Kyoto , Japan.
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000293:Adolescent; D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D017285:Polymyositis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D003520:Cyclophosphamide; D000604:Amino Acyl-tRNA Synthetases; D008775:Methylprednisolone
keywords: Aminoacyl-tRNA synthetase; Anti-OJ antibody; Anti-synthetase syndrome; Intravenous cyclophosphamide pulse therapy; Juvenile polymyositis