title: High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients.
abstract: BACKGROUND
  Hereditary triple-negative breast cancer patients have better recurrence-free survival than triple-negative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study.
  
  
  METHODS
  Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test.
  
  
  RESULTS
  MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p = 0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p = 0.0314).
  
  
  CONCLUSIONS
  Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Dagnija
authors.initials: D
authors.lastname: Kalniete
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Miki
authors.initials: M
authors.lastname: Nakazawa-Miklaševiča
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Ilze
authors.initials: I
authors.lastname: Štrumfa
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Arnis
authors.initials: A
authors.lastname: Āboliņš
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia ; Breast Disease Center, Pauls Stradins Clinical University Hospital, Pilsonu Street 13, Riga, LV-1002 Latvia.
authors.forename: Arvīds
authors.initials: A
authors.lastname: Irmejs
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Jānis
authors.initials: J
authors.lastname: Gardovskis
authors.affiliation: Institute of Oncology, Riga Stradins University, Dzirciema Street 16, Riga, LV-1007 Latvia.
authors.forename: Edvīns
authors.initials: E
authors.lastname: Miklaševičs
keywords: Hereditary and sporadic breast cancers; MiRNA expressionm; Triple-negative subtype