title: Cerebral Thrombotic Complications Related to l-Asparaginase Treatment for Acute Lymphoblastic Leukemia: Retrospective Review of 10 Cases.
abstract: l-Asparaginase is a potent antileukemia agent and an essential part of treatment protocols for acute lymphoblastic leukemia. However, toxicity limits dose escalation, especially in adults. This includes a significant risk of thrombosis, which remains an important source of avoidable morbidity and mortality. Here, we provide a detailed report of 10 cases of cerebral thrombotic complications that occurred over a 5-year period at 4 large tertiary referral hospitals. To our knowledge, this is the first report of this type in the published literature.
authors.affiliation: Department of Haematology, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Eden
authors.affiliation: Russells Hall Hospital, Dudley, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Hipkins
authors.affiliation: Department of Haematology, University Hospital Bristol NHS Trust, Bristol, United Kingdom University of Bristol, Bristol, United Kingdom c.bradbury@bristol.ac.uk.
authors.forename: C A
authors.initials: CA
authors.lastname: Bradbury
mesh_terms: D000293:Adolescent; D000328:Adult; D001215:Asparaginase / Q000009:adverse effects*; D002648:Child; D003625:Data Collection; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D020767:Intracranial Thrombosis / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy
chemical_list: D001215:Asparaginase
keywords: ALL; l-asparaginase; thrombosis