title: Stability Evaluation of Ivermectin-Loaded Biodegradable Microspheres.
abstract: A stability study was performed on ivermectin (IVM)-loaded biodegradable microparticles intended for injection in dogs. The rational was to evaluate the performances upon irradiation of a drug, such as IVM, with a few criticalities with respect to its stability, and toxicity. The goal was to provide valuable information for pharmaceutical scientists and manufacturers working in the veterinary area. The microspheres based on poly(D,L-lactide) and poly-(ε-caprolactone) and loaded with IVM and with the addition of alpha-tocopherol (TCP) as antioxidant were prepared by the emulsion solvent evaporation method and sterilized by gamma irradiation. Microsphere characterization in term of size, shape, polymer, and IVM stability upon irradiation was performed. The results show that the type of polymer significantly affects microsphere characteristics and performances. Moreover, suitably stable formulations can be achieved only by TCP addition.
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Dorati
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Ida
authors.initials: I
authors.lastname: Genta
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Colzani
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Modena
authors.affiliation: Department of Chemistry, section of Physical Chemistry, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Bruni
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tripodo
authors.affiliation: Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100, Pavia, Italy. bice.conti@unipv.it.
authors.forename: Bice
authors.initials: B
authors.lastname: Conti
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000528:radiation effects; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry; D005720:Gamma Rays; D007559:Ivermectin / Q000737:chemistry* / Q000528:radiation effects; D008863:Microspheres; D008956:Models, Chemical; D011091:Polyesters / Q000737:chemistry*; D012995:Solubility; D019155:Veterinary Drugs / Q000737:chemistry* / Q000528:radiation effects; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D000975:Antioxidants; D000977:Antiparasitic Agents; D004337:Drug Carriers; D005079:Excipients; D011091:Polyesters; D019155:Veterinary Drugs; C016240:polycaprolactone; C033616:poly(lactide); D007559:Ivermectin; D024502:alpha-Tocopherol
keywords: alpha-tocopherol; gamma irradiation; ivermectin; microspheres; poly(D,L-lactide); poly-(ε-caprolactone)