title: Clearance rate and BP-ANN model in paraquat poisoned patients treated with hemoperfusion.
abstract: In order to investigate the effect of hemoperfusion (HP) on the clearance rate of paraquat (PQ) and develop a clearance model, 41 PQ-poisoned patients who acquired acute PQ intoxication received HP treatment. PQ concentrations were determined by high performance liquid chromatography (HPLC). According to initial PQ concentration, study subjects were divided into two groups: Low-PQ group (0.05-1.0 μg/mL) and High-PQ group (1.0-10 μg/mL). After initial HP treatment, PQ concentrations decreased in both groups. However, in the High-PQ group, PQ levels remained in excess of 0.05 μg/mL and increased when the second HP treatment was initiated. Based on the PQ concentrations before and after HP treatment, the mean clearance rate of PQ calculated was 73 ± 15%. We also established a backpropagation artificial neural network (BP-ANN) model, which set PQ concentrations before HP treatment as input data and after HP treatment as output data. When it is used to predict PQ concentration after HP treatment, high prediction accuracy (R = 0.9977) can be obtained in this model. In conclusion, HP is an effective way to clear PQ from the blood, and the PQ concentration after HP treatment can be predicted by BP-ANN model.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Lufeng
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Hong
authors.affiliation: Function Experiment Teaching Center, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Jianshe
authors.initials: J
authors.lastname: Ma
authors.affiliation: Function Experiment Teaching Center, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Xianqin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Guanyang
authors.initials: G
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Zhongqiu
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology*; D008875:Middle Aged; D016571:Neural Networks, Computer; D010269:Paraquat / Q000097:blood* / Q000378:metabolism* / Q000506:poisoning; D055815:Young Adult
chemical_list: D010269:Paraquat