title: Transcription factors and chromatin proteins as therapeutic targets in cancer.
abstract: Targeting the factors that regulate gene transcription is a compelling strategy in cancer therapeutics. Traditionally, these have been considered intractable targets, but recent work has revealed novel strategies for the regulation of transcription factor activity in cancer. This review will highlight some of the emerging concepts and provide examples where agents that target transcription factors are being exploited clinically for cancer therapies.
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Johnston
authors.affiliation: Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK. Electronic address: jason.carroll@cruk.cam.ac.uk.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Carroll
mesh_terms: D002843:Chromatin / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D034741:RNA, Small Interfering / Q000627:therapeutic use; D015398:Signal Transduction / Q000187:drug effects; D054852:Small Molecule Libraries / Q000627:therapeutic use*; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000627:therapeutic use
chemical_list: D002843:Chromatin; D034741:RNA, Small Interfering; D054852:Small Molecule Libraries; D014157:Transcription Factors
keywords: Cancer; Drugs; Nuclear receptors; Small molecules; Transcription factors; siRNA