title: What is the effect of rivaroxaban on routine coagulation tests?
abstract: A 78-year-old female presents to the emergency department with a traumatic hip fracture. Her past medical history is significant for atrial fibrillation for which she receives rivaroxaban 20 mg daily. Her dose was last taken 12 hours ago. Routine bloodwork conducted in the emergency department shows prothrombin time, international normalized ratio, and activated partial thromboplastin time within the normal range, and estimated glomerular filtration rate of 50 mL/min/1.73 m(2) (normal is >90 mL/min/1.73 m(2)) You are asked by the surgical team to confirm that it is safe to proceed with surgery at this time using neuraxial anesthesia.
authors.affiliation: Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; and Puget Sound Blood Center and Department of Medicine, Division of Hematology, University of Washington, Seattle, WA.
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Siegal
authors.affiliation: Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; and Puget Sound Blood Center and Department of Medicine, Division of Hematology, University of Washington, Seattle, WA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Konkle
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D009025:Morpholines / Q000494:pharmacology*; D010314:Partial Thromboplastin Time; D000069552:Rivaroxaban; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D009025:Morpholines; D013876:Thiophenes; D000069552:Rivaroxaban