title: ADAMTS proteases in vascular biology.
abstract: ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases comprise the most recently discovered branch of the extracellular metalloenzymes. Research during the last 15years, uncovered their association with a variety of physiological and pathological processes including blood coagulation, tissue repair, fertility, arthritis and cancer. Importantly, a frequent feature of ADAMTS enzymes relates to their effects on vascular-related phenomena, including angiogenesis. Their specific roles in vascular biology have been clarified by information on their expression profiles and substrate specificity. Through their catalytic activity, ADAMTS proteases modify rather than degrade extracellular proteins. They predominantly target proteoglycans and glycoproteins abundant in the basement membrane, therefore their broad contributions to the vasculature should not come as a surprise. Furthermore, in addition to their proteolytic functions, non-enzymatic roles for ADAMTS have also been identified expanding our understanding on the multiple activities of these enzymes in vascular-related processes.
authors.affiliation: GENYO, Centre for Genomics and Oncological Research, Pfizer, Universidad de Granada, Junta de Andalucía, 18016 Granada, Spain. Electronic address: juancarlos.rodriguez@genyo.es.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rodríguez-Manzaneque
authors.affiliation: GENYO, Centre for Genomics and Oncological Research, Pfizer, Universidad de Granada, Junta de Andalucía, 18016 Granada, Spain.
authors.forename: Rubén
authors.initials: R
authors.lastname: Fernández-Rodríguez
authors.affiliation: GENYO, Centre for Genomics and Oncological Research, Pfizer, Universidad de Granada, Junta de Andalucía, 18016 Granada, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Rodríguez-Baena
authors.affiliation: Department of Molecular, Cell, and Developmental Biology, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: arispe@mcdb.ucla.edu.
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Iruela-Arispe
mesh_terms: D051722:ADAM Proteins / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D001777:Blood Coagulation; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D017434:Protein Structure, Tertiary; D011509:Proteoglycans / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D006023:Glycoproteins; D011509:Proteoglycans; D051722:ADAM Proteins
keywords: ADAMTS; angiogenesis; extracellular proteolysis; vasculature