title: tranSMART: An Open Source Knowledge Management and High Content Data Analytics Platform.
abstract: The tranSMART knowledge management and high-content analysis platform is a flexible software framework featuring novel research capabilities. It enables analysis of integrated data for the purposes of hypothesis generation, hypothesis validation, and cohort discovery in translational research. tranSMART bridges the prolific world of basic science and clinical practice data at the point of care by merging multiple types of data from disparate sources into a common environment. The application supports data harmonization and integration with analytical pipelines. The application code was released into the open source community in January 2012, with 32 instances in operation. tranSMART's extensible data model and corresponding data integration processes, rapid data analysis features, and open source nature make it an indispensable tool in translational or clinical research.
authors.affiliation: Recombinant By Deloitte, Newton MA ; Harvard Medical School, Boston, MA.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Scheufele
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Dina
authors.initials: D
authors.lastname: Aronzon
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Robert
authors.initials: R
authors.lastname: Coopersmith
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: McDuffie
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Manish
authors.initials: M
authors.lastname: Kapoor
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Uhrich
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Jean E
authors.initials: JE
authors.lastname: Avitabile
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Jinlei
authors.initials: J
authors.lastname: Liu
authors.affiliation: Recombinant By Deloitte, Newton MA.
authors.forename: Dan
authors.initials: D
authors.lastname: Housman
authors.affiliation: Recombinant By Deloitte, Newton MA ; Harvard Medical School, Boston, MA.
authors.forename: Matvey B
authors.initials: MB
authors.lastname: Palchuk