title: [The problems of experimental investigation of spaceflight factors combined influence on animals organism functions].
abstract: The brief analytic review of exceedingly important, tough, but the insufficient investigated problem of experimental investigation of spaceflight factors (SF) combined influence on animal organism functions is the content of this paper. The basic limited factor for interplanetary spaceflights is ionizing radiation. Therefore, in the paper studies the matters of the effects of combined influence and the different nonradiation SF. In this case the possible disturbances of central nervous system functions are the most important, because they present the basic danger for space mission performance and the cosmonauts life directly in spaceflight. Besides of that, in the paper studies the matters of character of interaction and mutual modifications of the combined effects of different SF: hypodynamia, G force, vibration, hypoxia, hyperthermia. The effects of this factor may have additive, potentiative, synergic or antagonistic character. In studies of SF combined influence effects the accentuation of the key factor and organism system that is targeted for this factor influence is necessary.
authors.forename: A S
authors.initials: AS
authors.lastname: Shtemberg
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D018471:Hypergravity; D013026:Space Flight; D014893:Weightlessness