[Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].
The influence of the organospecific peptides--kidney tripeptides T-31 and T-35, pineal tetrapeptide epitalon on the main mechanisms of kidney injury caused by experimental rhabdomyolysis--toxic injury of tubular cells, development of oxidative stress and energetic misbalance, leading to significant disturbances of the functional state of kidneys and development of acute kidney failure was studied. The renoprotective effect of oligopeptides realized by impact on all of the indicated mechanisms of kidney injury and confirmed by correlation between them was estimated.
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Zamorskiĭ
T S
TS
Shchudrova
D058186:Acute Kidney Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D010870:Pineal Gland / Q000378:metabolism / Q000473:pathology; D012206:Rhabdomyolysis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
D009842:Oligopeptides