Pathophysiology of venous thrombosis.
In this chapter, an overview of some of the prominent risk factors that contribute to the pathophysiology of venous thrombosis will be discussed. In 1856, Dr Rudolf Virchow developed the concept outlining the genesis of intravascular thrombosis. Dr Virchow hypothesized that circulatory stasis due to interrupted blood flow, changes in the blood leading to blood coagulation, and irritation or damage to the vascular endothelium would initiate acute venous thrombus generation. Presently, it is known that these above-mentioned risk factors are influenced by increasing age, gender, and obesity. The current chapter will focus on recent preclinical and clinical investigations that will give the reader insight into the prothrombotic mechanisms that lead to acute venous thrombosis.
Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, USA ddmyers@umich.edu.
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D000367:Age Factors; D001777:Blood Coagulation; D001783:Blood Flow Velocity; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009765:Obesity / Q000473:pathology / Q000503:physiopathology*; D012737:Sex Factors; D020246:Venous Thrombosis / Q000473:pathology / Q000503:physiopathology*
Venous thrombosis; acute venous thrombosis; risk factors for thrombosis; venous disease