MQAPsingle: A quasi single-model approach for estimation of the quality of individual protein structure models.
We present a Model Quality Assessment Program (MQAP), called MQAPsingle, for ranking and assessing the absolute global quality of single protein models. MQAPsingle is quasi single-model MQAP, a method that combines advantages of both "pure" single-model MQAPs and clustering MQAPs. This approach results in higher accuracy compared to the state-of-the-art single-model MQAPs. Notably, the prediction for a given model is the same regardless if this model is submitted to our server alone or together with other models. Proteins 2016; 84:1021-1028. © 2015 Wiley Periodicals, Inc.
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, 43205.
Marcin
M
Pawlowski
Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Warsaw, PL-02-109, Poland.
Lukasz
L
Kozlowski
Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, 43205.|Department of Pediatrics, The Ohio State University, Columbus, Ohio, 43205.|Kavli Institute for Theoretical Physics China, Chinese Academy of Sciences, Beijing, 100190, China.
Andrzej
A
Kloczkowski
D019985:Benchmarking; D053455:Caspase 10 / Q000737:chemistry*; D019295:Computational Biology / Q000379:methods*; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D012984:Software
D053455:Caspase 10; C506438:CASP10 protein, human
CASP10; MQAP; model correctness; model quality assessment; protein prediction; protein structure; single-model MQAP