Improvement of cytocompatibility of polylactide by filling with marine algae powder.
This work evaluated the cytocompatibility, thermal and mechanical properties of composites of polylactide (PLA) and marine algae powder (MAP). To improve the thermal and mechanical properties of PLA-MAP composites, glycidyl methacrylate (GMA) was used as the compatibilizer for the blending of PLA and MAP. The PLA-g-GMA/MAP composites exhibited superior mechanical properties, attributing to higher compatibility between the polymer and MAP, comparing to PLA/MAP composites. The dispersion of MAP in the PLA-g-GMA matrix was highly homogeneous as a result of etherification. The lower melt torque of the PLA-g-GMA/MAP composites also made them more processable than PLA/MAP. To assess the cytocompatibility, normal human foreskin fibroblasts (FBs) were seeded onto each type of the composites. Results of FB proliferation, collagen production, and cytotoxicity assays indicated greater cytocompatibility for the PLA/MAP composites than for the PLA-g-GMA/MAP composites. Furthermore, both PLA/MAP and PLA-g-GMA/MAP composites were more cytocompatible than pure PLA.
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Tung-Yi
TY
Wu
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. Electronic address: myang@mail.ntust.edu.tw.
Ming-Chien
MC
Yang
Graduate Institute of Medical Science, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan; Innovative Research Center of Medicine, College of Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan.
Yi-Chiang
YC
Hsu
D017304:Annexin A5 / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects; D059001:Aquatic Organisms / Q000737:chemistry*; D001672:Biocompatible Materials / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D049109:Cell Proliferation / Q000187:drug effects; D000460:Chlorophyta / Q000737:chemistry*; D003094:Collagen / Q000096:biosynthesis; D004548:Elasticity / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D016650:Fluorescein-5-isothiocyanate / Q000378:metabolism; D006801:Humans; D008297:Male; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology*; D011208:Powders; D013696:Temperature; D019415:Torque; D014783:Viscosity / Q000187:drug effects
D017304:Annexin A5; D001672:Biocompatible Materials; D004852:Epoxy Compounds; D008689:Methacrylates; D011091:Polyesters; D011208:Powders; C033616:poly(lactide); D003094:Collagen; D016650:Fluorescein-5-isothiocyanate; C007870:glycidyl methacrylate
Cytocompatibility; Marine algae powder; Mechanical properties; Polylactide; Thermal properties