CD147 and Ki-67 overexpression confers poor prognosis in squamous cell carcinoma of oral tongue: a tissue microarray study.
OBJECTIVE
Squamous cell carcinoma of the oral tongue (SCCOT) exhibits high risk for recurrence and regional metastasis even after surgical resection. We assessed the clinicopathologic and prognostic significance of a group of functionally related biomarkers.


METHODS
We used a tissue microarray consisting of SCCOT from 32 patients for this study. These patients were treated at the University of Texas MD Anderson Cancer Center from 1995 to 2008. Biomarker expression levels were examined by immunohistochemistry and graded semiquantitatively to determine their prognostic significance.


RESULTS
CD147 and Tp63 expressions were significantly associated with a higher T stage and Ki-67 labeling index, as well as a shorter overall survival (OS) rate. Expression of Tp63 associated positively with poorly differentiated histology. There was significant association of Tp63 with the expression levels of CD147 and Glut-1. Glut-1 overexpression was marginally associated with a higher T stage. There was no prognostic significance of CD44 v6 expression in SCCOT.


CONCLUSIONS
SCCOT with CD147 overexpression in combination with high Ki-67 labeling index had poor OS. CD147 and Ki-67 overexpression is associated with aggressive disease with poor prognosis in SCCOT.
Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston, Houston, TX; Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA.
Yau-Hua
YH
Yu
Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston, Houston, TX; Department of Orthodontics, Georgia Regents University, 1120 15th Street, GC-2144, Augusta, Georgia.
Jose
J
Morales
Departments of Biostatistics and Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
Lei
L
Feng
Departments of Biostatistics and Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
J Jack
JJ
Lee
Departments of Biostatistics and Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
Adel K
AK
El-Naggar
Department of Diagnostic and Biomedical Sciences, The University of Texas School of Dentistry at Houston, Houston, TX. Electronic address: Nadarajah.vigneswaran@uth.tmc.edu.
Nadarajah
N
Vigneswaran
D000328:Adult; D000368:Aged; D051926:Basigin / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D046888:Tissue Array Analysis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014157:Transcription Factors / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000378:metabolism
C497886:BSG protein, human; D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; D051272:Glucose Transporter Type 1; D018960:Hyaluronan Receptors; D019394:Ki-67 Antigen; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D051926:Basigin