[P-glycoprotein: structure, physiological role and molecular mechanisms of modulation functional activity].
In the review of literature the structure, localization and a physiological role of efflux biobiotics and xenobiotics transporter - P-glycoprotein - is characterized, molecular mechanisms of induction and inhibition of its functional activity are systematized.
E N
EN
Iakusheva
I V
IV
Chernykh
A V
AV
Shchul'kin
N M
NM
Popova
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D018628:Gene Dosage; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D021381:Protein Transport; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D015262:Xenobiotics / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D012333:RNA, Messenger; D015262:Xenobiotics