Longitudinal observation of children with enhanced total serum IgE.
BACKGROUND
Long-term studies on the evolution of elevated total IgE (tIgE) concentration are in demand.


OBJECTIVE
To investigate the prevalence of allergic diseases and influential factors in children with high tIgE levels during a 5-year period.


METHODS
Children with high tIgE levels (>100 IU/mL) were study subjects. After the 5-year follow-up, an interview with the parents, clinical examination, and evaluation of tIgE and specific IgE (sIgE) to selected food and inhalant allergens were performed.


RESULTS
The mean tIgE decreased significantly after 5 years in girls and boys regardless of the place of residence. Monosymptomatic patients accounted for most cases throughout the study, with the highest tIgE level at the beginning. After follow-up, the percentage of polysymptomatic patients increased. Their mean tIgE level was significantly higher than in the other groups. After follow-up, 11.7% of participants remained asymptomatic, and another 11.7% reported relief from symptoms. Allergy symptoms persisted in most children with normal tIgE levels. The 2-allergen sensitization was the most common through the study. Only patients sensitized to 4 allergens had unchanged levels of mean tIgE after follow-up and those with the highest mean tIgE level had a newly diagnosed sensitization to at least 1 allergen. A significant decrease of sIgE level was observed for food allergens. The values of sIgE to inhalant allergens even increased after the 5-year follow-up, despite decreased tIgE levels.


CONCLUSIONS
In children with allergy and an elevated concentration of tIgE, the increasing or stable value of tIgE could be a useful parameter for the prediction of the development of polysymptomatic allergy.
Department of Pediatrics, Gastroenterology and Allergology, Medical University in Bialystok, Bialystok, Poland. Electronic address: ula.daniluk@wp.pl.
Urszula
U
Daniluk
Department of Clinical Immunology, Medical University in Bialystok, Bialystok, Poland.
Marek
M
Alifier
Department of Pediatrics, Gastroenterology and Allergology, Medical University in Bialystok, Bialystok, Poland.
Maciej
M
Kaczmarski
Department of Clinical Immunology, Medical University in Bialystok, Bialystok, Poland.
Anna
A
Stasiak-Barmuta
Department of Pediatrics, Gastroenterology and Allergology, Medical University in Bialystok, Bialystok, Poland.
Dariusz
D
Lebensztejn
D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D011795:Surveys and Questionnaires
D007073:Immunoglobulin E