Dedifferentiation, Transdifferentiation, and Proliferation: Mechanisms Underlying Cardiac Muscle Regeneration in Zebrafish.
The adult mammalian heart is increasingly recognized as a regenerative organ with a measurable capacity to replenish cardiomyocytes throughout its lifetime, illuminating the possibility of stimulating endogenous regenerative capacity to treat heart diseases. Unlike mammals, certain vertebrates possess robust capacity for regenerating a damaged heart, providing a model to understand how regeneration could be augmented in injured human hearts. Facilitated by its rich history in the study of heart development, the teleost zebrafishDanio reriohas been established as a robust model to investigate the underlying mechanism of cardiac regeneration. This review discusses the current understanding of the endogenous mechanisms behind cardiac regeneration in zebrafish, with a particular focus on cardiomyocyte dedifferentiation, transdifferentiation, and proliferation.
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010 Australia ; St. Vincent's Clinical School, University of New South Wales, Kensington, NSW 2052 Australia.
Kazu
K
Kikuchi
Cardiomyocyte; Dedifferentiation; Proliferation; Regeneration; Transdifferentiation; Zebrafish