Need of voriconazole high dosages, with documented cerebrospinal fluid penetration, for treatment of cerebral aspergillosis in a 6-month-old leukaemic girl.
This case report indicates the usefulness of voriconazole for the treatment of central nervous system (CNS) aspergillosis, also in paediatrics. However, it also confirms the need for therapeutic drug monitoring (TDM), especially in younger children that may require very high dosages in order to achieve plasma and cerebrospinal fluid (CSF) therapeutic concentrations.
a Hematology Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Elena
E
Palmisani
b Laboratory of Analyses , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Sebastiano
S
Barco
b Laboratory of Analyses , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Giuliana
G
Cangemi
c Infectious Diseases Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Cristina
C
Moroni
a Hematology Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Carlo
C
Dufour
c Infectious Diseases Unit , Istituto Giannina Gaslini - Ospedale Pediatrico IRCCS , Genova , Italy.
Elio
E
Castagnola
D000935:Antifungal Agents / Q000008:administration & dosage* / Q000134:cerebrospinal fluid; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D020953:Neuroaspergillosis / Q000188:drug therapy* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D065819:Voriconazole / Q000008:administration & dosage* / Q000134:cerebrospinal fluid
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D065819:Voriconazole
Cerebral aspergillosis; Cerebrospinal fluid concentrations; Children; Leukaemia; Voriconazole