Histopathological, histomorphometrical, and radiographical evaluation of injectable glass-ceramic-chitosan nanocomposite in bone reconstruction of rat.
Background. Bone defects following tumor resection and osteolysis due to bone lesions, periodontal tissue disorders, and bone reconstruction are challenges that surgeons face. Gass-ceramic-chitosan nanocomposite contains chitosan, a derivative of crustaceans' exoskeleton. Methods. Thirty-two 6-8-week-old male Wistar rats were chosen. One hole on each right and left tibia was made. The right tibia holes were filled with injectable glass-ceramic-chitosan nanocomposite, and the left tibia holes were left empty. After 7, 14, 28, and 60 days, histopathological, histomorphometrical, and radiographical assessments were performed. Results. Radiographic density on days 7 and 14 was significantly higher in the right tibias than in the left tibias. Trabecular bone thickness, which was higher in the right tibias, increased from day 7 to day 60 in both right and left tibias, although not significantly. Conclusions. Glass-ceramic-chitosan nanocomposite is suggested for use in bone repair in cases of bone loss. More histopathological, histomorphometrical, and radiographical assessments are also recommended.
Dental Materials Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Maryam
M
Seyedmajidi
Department of Materials Engineering, School of Mechanic Engineering, Babol University of Technology, Babol, Iran.
Seyedmahmood
S
Rabiee
Oral & Maxillofacial Radiology Department, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Sina
S
Haghanifar
Department of Materials Engineering, School of Mechanic Engineering, Babol University of Technology, Babol, Iran.
Seyedkamal
S
Seyedmajidi
Fatemeh Zahra Infertility and Reproductive Health Research Center, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Seyed Gholam Ali
SG
Jorsaraei
Operative Dentistry Department, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Homayoun
H
Alaghehmand
Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
Naghmeh
N
Jamaatlu
Non-communicable Pediatrics Disease Research Center, Babol University of Medical Sciences, Babol, Iran.
Ali
A
Bijani