Familial isolated pituitary adenomas (FIPA) and mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.
The most frequent conditions that are associated with inherited/familial pituitary adenomas are familial isolated pituitary adenoma (FIPA) and multiple endocrine neoplasia type 1 (MEN1), which together account for up to 5% of pituitary adenomas. One important genetic cause of FIPA are inactivating mutations or deletions in the aryl hydrocarbon receptor interacting protein (AIP) gene. FIPA is the most frequent clinical presentation of AIP mutations. This article traces the current state of knowledge regarding the clinical features of FIPA and the particular genetic, pathologic, and clinical characteristics of pituitary adenomas due to AIP mutations.
Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège 4000, Belgium.
Adrian F
AF
Daly
Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège 4000, Belgium. Electronic address: albert.beckers@chu.ulg.ac.be.
Albert
A
Beckers
D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; C103265:aryl hydrocarbon receptor-interacting protein
AIP; Acromegaly; Aggressive; FIPA; Genetics; Pediatric; Somatotropinoma