[Functional interactions of Na,K-ATPase with molecular environment].
The present review covers the analysis of research in the field of intermolecular interactions of Na,K-ATPase which underlie novel cellular regulatory mechanisms. The capability of Na,K-ATPase to form multimolecular regulatory complexes and take part as a scaffolding protein in formation of cell functional and signaling microcompartments is considered. Particular attention is directed to membrane lipid microdomains (rafts, caveolae). Mechanisms of signaling and neuroprotective functions of Na,K-ATPase as well as the involvement of endogenous cardiotonic steroids in their realization are discussed. This review demonstrates novel data on functional interactions of Na,K-ATPase with neurotransmitter receptors and other proteins involved in regulation of synaptic transmission.
I I
II
Krivoĭ
D000818:Animals; D021941:Caveolae / Q000378:metabolism*; D006801:Humans; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
D017981:Receptors, Neurotransmitter; D000254:Sodium-Potassium-Exchanging ATPase