Comparison of diabetic and non-diabetic patients undergoing endovascular revascularization for peripheral arterial disease.
OBJECTIVE
Peripheral arterial disease (PAD) is associated with poor outcomes. We assessed the clinical outcomes of diabetic versus non-diabetic patients with PAD who underwent peripheral transluminal angioplasty (PTA).


METHODS
The outcomes of 239 consecutive patients with symptomatic PAD who underwent PTA were analyzed. Restenosis and clinical outcomes were assessed at a follow-up of 2 years.


RESULTS
Diabetic patients had a higher percentage of wound as the initial diagnosis for PTA (72.7% vs. 14.2%; P<.001), chronic kidney disease (26.7% vs. 6.3%; P<.01), need for dialysis (19.3% vs. 3.1%; P<.01), and coronary artery disease (67.6% vs. 50.7%; P=.02). Infrapopliteal PTA was more commonly performed in the diabetic group (70.4% vs. 25.3%; P<.001). Diabetic patients had lower rates of angiographic follow-up at 8 months (38.6% vs. 60.3%; P<.01). Diabetic patients had higher binary restenosis (54.4% vs. 31.5%; P=.02) and had a trend toward a higher incidence of total occlusion (34.0% vs. 19.5%; P=.08). At 2-year follow-up, the amputation rate was higher in the diabetic group (24.4% vs. 1.5%; P<.001) despite PTA.


CONCLUSIONS
Diabetic patients more frequently presented with critical limb ischemia compared with non-diabetic patients and had higher rates of restenosis and amputation at 2 years following standard PTA. Improved therapies are needed for this high-risk group of patients.
Cardiovascular Center, Korea University Guro Hospital, 80, Gurodong, Guro-gu, Seoul, 152-703, Korea. swrha617@yahoo.co.kr.
Michael S
MS
Lee
Seung-Woon
SW
Rha
Seung Kyu
SK
Han
Byoung Geol
BG
Choi
Se Yeon
SY
Choi
Jabar
J
Ali
Shaopeng
S
Xu
Harris Abdullah
HA
Ngow
Jae Joong
JJ
Lee
Kwang No
KN
Lee
Ji Bak
JB
Kim
Sunki
S
Lee
Jin Oh
JO
Na
Cheol Ung
CU
Choi
Hong Euy
HE
Lim
Jin Won
JW
Kim
Eung Ju
EJ
Kim
Chang Gyu
CG
Park
Hong Seog
HS
Seo
Jeremy
J
Kong
Dong Joo
DJ
Oh
D000368:Aged; D000792:Angiography; D017130:Angioplasty; D003920:Diabetes Mellitus; D003925:Diabetic Angiopathies / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D005263:Femoral Artery; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D011150:Popliteal Artery; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome