Kidney transplantation in children with decreased left ventricular systolic function: a Midwest Pediatric Nephrology Consortium study.
BACKGROUND
Left ventricular (LV) systolic dysfunction is a relatively uncommon but serious complication of pediatric chronic kidney disease, and may be related to uremia and uncontrolled hypertension. There is limited information on the strategy for managing these children. In some cases, combined heart-kidney transplant may be considered or kidney transplant delayed until cardiac function improves. It is unknown whether these patients are at increased risk for poor outcomes after kidney transplantation.


METHODS
We conducted a retrospective, multicenter study on the outcomes of children with severe and symptomatic cardiomyopathy who underwent kidney transplantation.


RESULTS
Eleven patients receiving maintenance dialysis with systolic dysfunction underwent kidney transplantation without simultaneous heart transplant. Nine patients had congestive heart failure in the pre-transplant period. There were no identified complications post-transplant related to the underlying cardiac dysfunction. LV systolic function normalized in all patients and the mean shortening fraction increased from 19.0 ± 4.6 % to 32.0 ± 4.4 % (p < 0.0001).


CONCLUSIONS
Kidney transplantation should be considered for children receiving maintenance dialysis with severe LV dysfunction.
Division of Pediatric Nephrology, University of Kansas Medical Center, Kansas City, KS, USA, sriar@kumc.edu.
Sandeep K
SK
Riar
Mark M
MM
Mitsnefes
Edward J
EJ
Nehus
Hiren P
HP
Patel
Julia M
JM
Steinke
Teri
T
Crumb
Elizabeth C
EC
Abraham
Margret W
MW
Kamel
Larry A
LA
Greenbaum
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000601:surgery*; D012189:Retrospective Studies; D018487:Ventricular Dysfunction, Left / Q000150:complications*