Contribution of mechanosensitive ion channels to somatosensation.
Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity of the genes encoding MSCs has remained largely elusive. Because these channels have an important role in the development of mechanical hypersensitivity, a better understanding of their function may lead to the identification of selective inhibitors and generate novel therapeutic pathways in the treatment of chronic pain. Here, I will describe our current understanding of the role MSCs may play in somatosensation and the potential candidate genes proposed to encode them.
Department of Physiology and Cell Information Systems Group, McGill University, Montreal, Quebec, Canada. Electronic address: Reza.Sharif@mcgill.ca.
Reza
R
Sharif-Naeini
D000818:Animals; D006801:Humans; D006930:Hyperalgesia / Q000378:metabolism; D015640:Ion Channel Gating; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D040542:Mechanotransduction, Cellular; D009619:Nociceptors / Q000378:metabolism; D012677:Sensation
D007473:Ion Channels
Inflammation; Mechanical allodynia; Mechanosensation; Mechanosensitive ion channels; Mechanotransduction; Nociceptor; Osteoarthritis; Pain