Modifying mitochondrial tRNAs: delivering what the cell needs.
Protein synthesis is critically dependent on transfer (t)-RNAs, but the factors regulating tRNA function are poorly understood. In this issue of Cell Metabolism, Wei et al. (2015) show that Cdk5 regulatory subunit-associated protein-like-1 synchronizes mitochondrial and cytosolic translation in response to external stress, providing key insight into the pathogenesis of a common inherited mitochondrial disease.
Institute of Genetic Medicine, Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.
Rita
R
Horvath
Institute of Genetic Medicine, Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK. Electronic address: p.f.chinnery@ncl.ac.uk.
Patrick F
PF
Chinnery
D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics*; D028361:Mitochondrial Diseases / Q000235:genetics*; D009135:Muscular Diseases / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D012343:RNA, Transfer / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D012343:RNA, Transfer