Optical probes for the detection of protons, and alkali and alkaline earth metal cations.
Luminescent sensors and switches continue to play a key role in shaping our understanding of key biochemical processes, assist in the diagnosis of disease and contribute to the design of new drugs and therapies. Similarly, their contribution to the environment cannot be understated as they offer a portable means to undertake field testing for hazardous chemicals and pollutants such as heavy metals. From a physiological perspective, the Group I and II metal ions are among the most important in the periodic table with blood plasma levels of H(+), Na(+) and Ca(2+) being indicators of several possible disease states. In this review, we examine the progress that has been made in the development of luminescent probes for Group I and Group II ions as well as protons. The potential applications of these probes and the mechanism involved in controlling their luminescent response upon analyte binding will also be discussed.
Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK. j.callan@ulster.ac.uk.
Graham R C
GR
Hamilton
Suban K
SK
Sahoo
Sukanta
S
Kamila
Narinder
N
Singh
Navneet
N
Kaur
Barry W
BW
Hyland
John F
JF
Callan
D000468:Alkalies / Q000097:blood*; D015374:Biosensing Techniques; D002412:Cations / Q000097:blood*; D005456:Fluorescent Dyes; D006801:Humans; D008673:Metals, Alkaline Earth / Q000097:blood*; D008958:Models, Molecular; D061848:Optical Imaging; D011522:Protons
D000468:Alkalies; D002412:Cations; D005456:Fluorescent Dyes; D008673:Metals, Alkaline Earth; D011522:Protons