Is Pseudoexfoliation Syndrome a Risk Factor for Cerebro Vascular Disease?
OBJECTIVE
To determine the relationship between cerebro vascular disease and pseudoexfoliation syndrome.


METHODS
This cross-sectional case control study consisted of 50 patients with ischemic-type cerebro vascular disease and 50 control subjects. All subjects were investigated for diabetes mellitus and hypertension status and underwent a detailed ophthalmic examination. A diagnosis of pseudoexfoliation syndrome was made if characteristic greyish particulate matter was found on the anterior lens capsule after pupillary dilatation by slit-lamp examination. All subjects were compared in terms of pseudoexfoliation syndrome, diabetes mellitus, and hypertension. Pearson Chi Square and Student's t test were used for statistical analysis. Logistic regression analyses of the risk factors between groups were also made.


RESULTS
The presence of pseudoexfoliation syndrome was significantly higher in patients with cerebro vascular disease when compared to the control subjects (p = 0.02). The frequency of diabetes mellitus was similar between the two groups. Arterial hypertension was significantly more frequent in the patient group when compared to the control subjects (p < 0.01). The logistic regression analysis showed that both pseudoexfoliation syndrome and hypertension were significantly associated with cerebro vascular disease.


CONCLUSIONS
In the present study, we found that pseudoexfoliation syndrome frequency was found to be higher in patients with cerebro vascular disease than in control subjects. A slit-lamp examination of the eye could be an important marker that indicates the risk of cerebro vascular disease. We recommend an evaluation of all subjects with pseudoexfoliation syndrome for the presence of cerebro vascular disease. Longitudinal studies with larger populations are needed to confirm this relationship.
a Samsun Training and Research Hospital , Samsun , Turkey.
Emrah
E
Kan
a Samsun Training and Research Hospital , Samsun , Turkey.
Ahmet
A
Yılmaz
a Samsun Training and Research Hospital , Samsun , Turkey.
Mehmet Derya
MD
Demirağ
a Samsun Training and Research Hospital , Samsun , Turkey.
Murat
M
Çalık
D000368:Aged; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D017889:Exfoliation Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
Arterial hypertension; cerebral embolism; cerebro vascular disease; diabetes mellitus; pseudoexfoliation syndrome