Serum anti-tissue transglutaminase antibodies detected during febrile illness may not be produced by the intestinal mucosa.
Anti-transglutaminase antibodies are the diagnostic marker of celiac disease, and are considered to be synthesized only by intestinal B-lymphocytes. During an infectious disease, these antibodies are transiently detected in serum. We show that these infection-triggered antibodies may not originate in the intestinal mucosa and are not an indication of celiac disease.
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Luigina
L
De Leo
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Sara
S
Quaglia
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Fabiana
F
Ziberna
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Serena
S
Vatta
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Stefano
S
Martelossi
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Massimo
M
Maschio
Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy. Electronic address: tarcisio.not@burlo.trieste.it.
Tarcisio
T
Not
D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000175:diagnosis / Q000201:enzymology* / Q000276:immunology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019204:GTP-Binding Proteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008297:Male; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000097:blood / Q000276:immunology*
D001323:Autoantibodies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins