[A case of pathological complete response with neoadjuvant XELOX chemotherapy for locally advanced rectal cancer].
A 70-year-old man presenting with melena was referred to our clinic. A clinical examination revealed a bulky tumor in the lower rectum. After ileostomy, 4 courses of capecitabine plus oxaliplatin (XELOX) therapy were administered as neoadjuvant chemotherapy. Computed tomography (CT) revealed significant reduction of the tumor. Laparoscopic super-low anterior resection with lateral lymph node dissection was performed. The pathological examination revealed no residual cancer cells, and a diagnosis of pathological complete response was made. The patient has been disease-free for 1 year after the operation. Neoadjuvant chemotherapy with XELOX might be promising for patients with locally advanced rectal cancer.
Dept. of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.
Tomohiro
T
Kitahara
Ichiro
I
Takemasa
Akira
A
Inoue
Hideki
H
Osawa
Masaaki
M
Miyo
Yukako
Y
Mokutani
Hisataka
H
Ogawa
Atsushi
A
Naito
Atsushi
A
Hamabe
Masayuki
M
Hiraki
Koji
K
Munakata
Mamoru
M
Uemura
Junichi
J
Nishimura
Taishi
T
Hata
Tsunekazu
T
Mizushima
Hirofumi
H
Yamamoto
Yuichiro
Y
Doki
Masaki
M
Mori
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D010535:Laparoscopy; D008197:Lymph Node Excision; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010071:Oxaloacetates; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil