Liver congestion in heart failure contributes to inappropriately increased serum hepcidin despite anemia.
Hepcidin is a key regulator of mammalian iron metabolism and mainly produced by the liver. Hepcidin excess causes iron deficiency and anemia by inhibiting iron absorption from the intestine and iron release from macrophage stores. Anemia is frequently complicated with heart failure. In heart failure patients, the most frequent histologic appearance of liver is congestion. However, it remains unclear whether liver congestion associated with heart failure influences hepcidin production, thereby contributing to anemia and functional iron deficiency. In this study, we investigated this relationship in clinical and basic studies. In clinical studies of consecutive heart failure patients (n = 320), anemia was a common comorbidity (41%). In heart failure patients without active infection and ongoing cancer (n = 30), log-serum hepcidin concentration of patients with liver congestion was higher than those without liver congestion (p = 0.0316). Moreover, in heart failure patients with liver congestion (n = 19), the anemia was associated with the higher serum hepcidin concentrations, which is a type of anemia characterized by induction of hepcidin. Subsequently, we produced a rat model of heart failure with liver congestion by injecting monocrotaline that causes pulmonary hypertension. The monocrotaline-treated rats displayed liver congestion with increase of hepcidin expression at 4 weeks after monocrotaline injection, followed by anemia and functional iron deficiency observed at 5 weeks. We conclude that liver congestion induces hepcidin production, which may result in anemia and functional iron deficiency in some patients with heart failure.
Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Yukako
Y
Ohno
Haruo
H
Hanawa
Shuang
S
Jiao
Yuka
Y
Hayashi
Kaori
K
Yoshida
Tomoyasu
T
Suzuki
Takeshi
T
Kashimura
Hiroaki
H
Obata
Komei
K
Tanaka
Tohru
T
Watanabe
Tohru
T
Minamino
D000368:Aged; D000740:Anemia / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000150:complications*; D064451:Hepcidins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood; D008107:Liver Diseases / Q000097:blood* / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016686:Monocrotaline; D009929:Organ Size; D010100:Oxygen / Q000097:blood; D015995:Prevalence; D011917:Rats, Inbred Lew
D015415:Biomarkers; D064451:Hepcidins; D016686:Monocrotaline; D007501:Iron; D010100:Oxygen