[Surgical treatment of the primary tumor in stage IV breast cancer].
BACKGROUND
The aim of the study was to analyze the impact of loco-regional surgery on survival of patients with stage IV breast cancer.


METHODS
Retrospective study that included patients with breast cancer and synchronous metastases. Patients with ECOG above 2 and high-risk patients were excluded. The following variables were evaluated: age, tumor size, nodal involvement, histological type, histological grade, hormone receptor status, HER2 overexpression, number of affected organs, location of metastases and surgical treatment. The impact of surgery and several clinical and pathologic variables on survival was analyzed by Cox regression model.


RESULTS
A total of 69 patients, of whom 36 (52.2%) underwent surgery (study group) were included. After a mean follow-up of 34 months, the median survival of the series was 55 months and no significant differences between the study group and the group of patients without surgery (P=0.187) were found. Two factors associated with worse survival were identified: the number of organs with metastases (HR=1.69, IC 95%: 1.05-2.71) and triple negative breast cancer (HR=3.49, IC 95%: 1.39-8.74). Loco-regional surgery, however, was not associated with survival.


CONCLUSIONS
Loco-regional surgical treatment was not associated with improved survival inpacientes with stage IV breast cancer. The number of organs with metastases and tumors were triple negative prognostic factors for survival.
Unidad de Patología Mamaria, Servicio de Cirugía General, Hospital Médico-Quirúrgico, Jaén, España. Electronic address: jimenezanula@hotmail.com.
Juan
J
Jiménez Anula
Unidad de Patología Mamaria, Servicio de Cirugía General, Hospital Médico-Quirúrgico, Jaén, España.
Belén
B
Sánchez Andújar
Unidad de Patología Mamaria, Servicio de Cirugía General, Hospital Médico-Quirúrgico, Jaén, España.
Pablo
P
Machuca Chiriboga
Unidad de Patología Mamaria, Servicio de Cirugía General, Hospital Médico-Quirúrgico, Jaén, España.
Joaquín
J
Navarro Cecilia
Unidad de Patología Mamaria, Servicio de Cirugía General, Hospital Médico-Quirúrgico, Jaén, España.
Basilio
B
Dueñas Rodríguez
D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018567:Breast Neoplasms, Male / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome
Breast cancer; Cirugía; Cáncer de mama; Estadio iv; Stage iv; Supervivencia; Surgery; Survival