A prognostic clinicopathologic classification of pituitary endocrine tumors.
Pituitary endocrine tumors are considered as benign. However, clinical and pathological data favor their consideration as more than an endocrinological disease. Using data from a retrospective case-control study of 410 patients, with 8 years of follow-up, the authors have validated a new clinicopathologic classification of pituitary tumors. This classification is based on tumor size, immunohistochemical type, and grade based on the assessment of invasion and proliferation, and it provides a prognostic value for predicting postoperative disease-free outcome or recurrence/progression status. This classification aids the identification of patients presenting with pituitary tumors that have a high risk of recurrence and enable construction of personalized therapies.
INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Neuro-Oncology & Neuro-Inflammation Team, Lyon F-69372, France; University of Lyon 1, Lyon F-69372, France; Department of Endocrinology, Groupement Hospitalier Est, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron F-69677, France.
Gérald
G
Raverot
INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Neuro-Oncology & Neuro-Inflammation Team, Lyon F-69372, France; University of Lyon 1, Lyon F-69372, France; Department of Pathology, Groupement Hospitalier Est, 59 Boulevard Pinel, Bron F-69677, France.
Alexandre
A
Vasiljevic
INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Neuro-Oncology & Neuro-Inflammation Team, Lyon F-69372, France; University of Lyon 1, Lyon F-69372, France; Department of Neurosurgery, Groupement Hospitalier Est, 59 Boulevard Pinel, Bron F-69677, France.
Emmanuel
E
Jouanneau
INSERM U1028, CNRS UMR5292, Lyon Neuroscience Research Center, Neuro-Oncology & Neuro-Inflammation Team, Lyon F-69372, France; University of Lyon 1, Lyon F-69372, France; Department of Pathology, Groupement Hospitalier Est, 59 Boulevard Pinel, Bron F-69677, France. Electronic address: jacqueline.trouillas@univ-lyon1.fr.
Jacqueline
J
Trouillas
D006801:Humans; D010911:Pituitary Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology
Classification; Pathologic markers; Pituitary endocrine tumor