Myocardial viability as integral part of the diagnostic and therapeutic approach to ischemic heart failure.
Chronic heart failure is a major public-health problem with a high prevalence, complex treatment, and high mortality. A careful and comprehensive analysis is needed to provide optimal (and personalized) therapy to heart failure patients. The main 4 non-invasive imaging techniques (echocardiography, magnetic resonance imaging, multi-detector-computed tomography, and nuclear imaging) provide information on cardiovascular anatomy and function, which form the basis of the assessment of the pathophysiology underlying heart failure. The selection of imaging modalities depends on the information that is needed for the clinical management of the patients: (1) underlying etiology (ischemic vs non-ischemic); (2) in ischemic patients, need for revascularization should be evaluated (myocardial ischemia/viability?); (3) left ventricular function and shape assessment; (4) presence of significant secondary mitral regurgitation; (5) device therapy with cardiac resynchronization therapy and/or implantable cardiac defibrillator (risk of sudden cardiac death). This review is dedicated to assessment of myocardial viability, however "isolated assessment of myocardial viability" may be clinically not meaningful and should be considered among all those different variables. This complete information will enable personalized treatment of the patient with ischemic heart failure.
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands, j.j.bax@lumc.nl.
Jeroen J
JJ
Bax
Victoria
V
Delgado
D003952:Diagnostic Imaging / Q000379:methods*; D019317:Evidence-Based Medicine; D006321:Heart / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy*; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D011379:Prognosis; D011877:Radionuclide Imaging; D014022:Tissue Survival; D016896:Treatment Outcome