An unusual cause of type 2 respiratory failure.
We present a female patient who was referred for management of respiratory failure. She was being evaluated and managed as worsening chronic inflammatory demyelinating polyneuropathy with type 2 respiratory failure. Initial examination showed hypertrichosis, clubbing and papilledema along with severe distal and proximal motor-predominant weakness with impending respiratory failure. She was managed with noninvasive ventilation (NIV) and plasmapheresis awaiting diagnostic investigations. Immunofixation showed an "M band" and free lambda chain levels were elevated. Radiographs showed the classic osteosclerotic lesions of POEMS (polyradiculoneuropathy, organomegaly, endocrinopathy, M-protein and Skin abnormalities) syndrome. Six weeks after commencing radiotherapy to the osteosclerotic lesions, the patient responded favorably and remains off nocturnal NIV support.
Department of Medicine, Jawarharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Srinivas
S
Rajagopala
Department of Medicine, Jawarharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Balamurugan
B
Nathan
Department of Medicine, Jawarharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Vivekanandan
V
Pillai
Chronic inflammatory demyelinating polyneuropathy; endocrinopathy; monoclonal gammopathy; multiple myeloma; organomegaly; plasmapheresis; polyradiculoneuropathy; type 2 respiratory failure