Recent progress in atomistic simulation of electrical current DNA sequencing.
We review recent advances in the DNA sequencing method based on measurements of transverse electrical currents. Device configurations proposed in the literature are classified according to whether the molecular fingerprints appear as the major (Mode I) or perturbing (Mode II) current signals. Scanning tunneling microscope and tunneling electrode gap configurations belong to the former category, while the nanochannels with or without an embedded nanopore belong to the latter. The molecular sensing mechanisms of Modes I and II roughly correspond to the electron tunneling and electrochemical gating, respectively. Special emphasis will be given on the computer simulation studies, which have been playing a critical role in the initiation and development of the field. We also highlight low-dimensional nanomaterials such as carbon nanotubes, graphene, and graphene nanoribbons that allow the novel Mode II approach. Finally, several issues in previous computational studies are discussed, which points to future research directions toward more reliable simulation of electrical current DNA sequencing devices.
School of Energy, Environment, Water, and Sustaibability, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea.
Han Seul
HS
Kim
School of Energy, Environment, Water, and Sustaibability, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea. Electronic address: y.h.kim@kaist.ac.kr.
Yong-Hoon
YH
Kim
D001483:Base Sequence; D003198:Computer Simulation; D017076:Computer-Aided Design; D003217:Conductometry / Q000295:instrumentation*; D004247:DNA / Q000737:chemistry* / Q000235:genetics* / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008956:Models, Chemical; D008969:Molecular Sequence Data; D058608:Nanopores / Q000648:ultrastructure*; D017422:Sequence Analysis, DNA / Q000295:instrumentation* / Q000379:methods
D004247:DNA
Atomistic simulation; Carbon nanotubes; DNA sequencing; Graphene; Nanopore; Quantum electron transport