Parenchymal lung changes on computed tomography after stereotactic radiotherapy using high dose rate flattening filter free beams.
Flattening filter free (FFF) beams allow fast delivery of stereotactic radiotherapy. To evaluate biological effects of FFF in lung, we compared parenchymal changes after FFF and non-FFF stereotactic volumetric modulated arc therapy. Standardized multi-observer consensus evaluation of follow-up CT scans revealed no major differences between FFF and non-FFF.
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: m.dahele@vumc.nl.
Max
M
Dahele
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
John R
JR
van Sörnsen de Koste
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
Peter M
PM
van de Ven
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Femke
F
Spoelstra
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Ben
B
Slotman
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Suresh
S
Senan
D000368:Aged; D005260:Female; D005374:Filtration; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D014057:Tomography, X-Ray Computed
Follow up; Lung cancer; Lung changes; Stereotactic radiotherapy; Toxicity