Anti-inflammatory Strategies to Prevent Diabetic Cardiovascular Disease.
Diabetes is a proinflammatory state and inflammation is crucial in the genesis of vascular complications. While there are many anti-inflammatory strategies, most of which have been shown to reduce inflammation in diabetes, there is sparse data on reduction in cardiovascular events (CVEs). To date, the only anti-inflammatory strategies that have been shown to reduce CVE in diabetes include statins, angiotensin receptor blockers, metformin, and pioglitazone. We also discuss the role of novel emerging therapies.
Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, California, USA.
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Jialal
Baylor College of Medicine, Houston, Texas, USA.
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Devaraj
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018570:Risk Assessment; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators