Two new naphthalene glucosides and other bioactive compounds from the carnivorous plant Nepenthes mirabilis.
Two new naphthalene diglucosides named nepenthosides A (1) and B (2), together with eleven known compounds (3-13), were isolated from the carnivorous plant Nepenthes mirabilis. The structures of these compounds were elucidated based on extensive spectroscopic analysis, including 1D- and 2D-NMR, and MS. The antioxidant activities of compounds 1-13 were evaluated in terms of their peroxyl radical-scavenging (trolox equivalent, TE) and reducing capacities. All isolates showed peroxyl radical-scavenging and reducing activities at concentrations of 1.0 and 10.0 μM. Anti-osteoporotic activities were investigated using murine osteoclastic RAW 264.7 cells. Compounds 1-7 and 9-12 significantly suppressed tartrate-resistant acid phosphatase activity down to 91.13 ± 1.18 to 42.39 ± 1.11%, relative to the control (100%) in nuclear factor-κB ligand (RANκL)-induced osteoclastic RAW 264.7 macrophage cells.
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Van
NV
Thanh
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.|College of Pharmacy, Chungnam National University, Daejeon, 305-764, Republic of Korea.
Nguyen Phuong
NP
Thao
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Le Duc
le D
Dat
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Phan Thi Thanh
PT
Huong
Department of Food and Nutrition, Hannam University, Daejeon, 305-811, Republic of Korea.
Sang Hyun
SH
Lee
Department of Food and Nutrition, Hannam University, Daejeon, 305-811, Republic of Korea.
Hae Dong
HD
Jang
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Xuan
NX
Cuong
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Nguyen Hoai
NH
Nam
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam.
Phan Van
PV
Kiem
Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam. cvminh@vast.vn.
Chau Van
CV
Minh
College of Pharmacy, Chungnam National University, Daejeon, 305-764, Republic of Korea. yhk@cnu.ac.kr.
Young Ho
YH
Kim
D000818:Animals; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D051379:Mice; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*
D016166:Free Radical Scavengers; D005960:Glucosides; D009281:Naphthalenes; D010545:Peroxides; D010936:Plant Extracts; C049375:perhydroxyl radical
Anti-osteoporosis activity; Antioxidant activity; Nepenthaceae; Nepenthes mirabilis; Nepenthoside A; Nepenthoside B