The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system.
In this review, we discuss the role of microtubule-associated protein 1B (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components, and regulate the stability and interaction of microtubules and actin to promote axonal growth, neural connectivity and regeneration in the central nervous system.
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Maoguang
M
Yang
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Minfei
M
Wu
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Peng
P
Xia
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Chunxin
C
Wang
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Peng
P
Yan
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Qi
Q
Gao
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Jian
J
Liu
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Haitao
H
Wang
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Xingwei
X
Duan
Department of Orthopedics, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Xiaoyu
X
Yang
axon guidance; axonal development; axonal regeneration; central nervous system; microtubule-associated protein 1B; neuronal migration