Effect of prostaglandin E1 versus corticotomy on orthodontic tooth movement: an in vivo study.
OBJECTIVE
The aim of the present study is to compare the effect of corticotomy versus prostaglandin E1 injection in human subjects on rate of tooth movement, anchorage loss and their effect on crest bone height and root length.


METHODS
Clinical interventional study. Split mouth design was used.


METHODS
Study was done on 32 regular orthodontic patients. A volume of 100 mcg of prostaglandin E1 was injected on the right side once in 2 weeks and on the left side corticotomy was performed, and canine retraction was started on both sides simultaneously. The rate of space closure and anchorage loss was assessed with casts. The root length and crestal bone height changes were assed with IOPAs. The comparison of rate of tooth movement, anchorage loss, crestal bone height and root length changes between the sides were statistically analyzed using paired t-test.


RESULTS
The average rate of space closure on right side was 0.36 mm/week with a standard deviation of 0.05 mm/week and on the left side average rate of space closure was 0.40 mm/week with a standard deviation of 0.04 mm/week. The difference between the rate of closure between the right side and left where found to be statistically significant (P=0.003). The anchorage loss, the crestal bone height changes and root length changes were not statistically significant.


CONCLUSIONS
The rate of tooth movement was significantly more with corticotomies when compared with given dose of prostaglandin injection.
Department of Orthodontics, A. B. Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.
U B
UB
Rajasekaran
U S
US
Krishna Nayak
D000293:Adolescent; D000527:Alprostadil / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D003481:Cuspid / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D052280:Orthodontic Anchorage Procedures / Q000295:instrumentation / Q000379:methods*; D019516:Orthodontic Space Closure / Q000295:instrumentation / Q000379:methods*; D010027:Osteotomy; D014087:Tooth Movement Techniques / Q000379:methods*; D055815:Young Adult
D000527:Alprostadil