HVEM expression contributes to tumor progression and prognosis in human colorectal cancer.
BACKGROUND
Herpesvirus entry mediator (HVEM) has been recently suggested to play certain roles in cancer biology. We examined HVEM expression in human colorectal cancer (CRC) to reveal its clinical importance.


METHODS
Immunohistochemical staining was carried-out in normal epithelium, benign and malignant lesions.


RESULTS
While intense HVEM expression was not observed in normal epithelium and hyperplastic polyps, 24% of adenoma and more than half of CRCs had high HVEM expression. In 234 CRCs, HVEM expression was significantly associated with tumor status and pathological stage. Patients with high HVEM expression had a significantly poorer prognosis than those with low expression. Importantly, HVEM status had an independent prognostic value in CRC. Furthermore, HVEM status was inversely corrected with the presence of tumor-infiltrating T-cells.


CONCLUSIONS
HVEM may play a critical role in tumor progression and immune evasion, and may also be a novel prognostic marker and potential therapeutic target in human CRC.
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Takashi
T
Inoue
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan m-sho@naramed-u.ac.jp.
Masayuki
M
Sho
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Satoshi
S
Yasuda
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Satoshi
S
Nishiwada
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Shinji
S
Nakamura
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Takeshi
T
Ueda
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Naoto
N
Nishigori
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Keijiro
K
Kawasaki
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Shinsaku
S
Obara
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Takayuki
T
Nakamoto
Department of Endoscopy and Ultrasound, Nara Medical University, Kashihara, Nara, Japan.
Fumikazu
F
Koyama
Department of Endoscopy and Ultrasound, Nara Medical University, Kashihara, Nara, Japan.
Hisao
H
Fujii
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Yoshiyuki
Y
Nakajima
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003106:Colon / Q000737:chemistry; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D008875:Middle Aged; D011379:Prognosis; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000032:analysis / Q000502:physiology*; D019139:Tumor Escape
D053240:Receptors, Tumor Necrosis Factor, Member 14; C506028:TNFRSF14 protein, human
Colorectal cancer; HVEM; prognosis; surgery; tumor immunity