Mannosylerythritol lipids: production and applications.
Mannosylerythritol lipids (MELs) are a glycolipid class of biosurfactants produced by a variety yeast and fungal strains that exhibit excellent interfacial and biochemical properties. MEL-producing fungi were identified using an efficient screening method for the glycolipid production and taxonomical classification on the basis of ribosomal RNA sequences. MEL production is limited primarily to the genus Pseudozyma, with significant variability among the MEL structures produced by each species. Outside of Pseudozyma, one recently isolated strain, Ustilago scitaminea, has been shown to exhibit abundant MEL-B production from sugarcane juice. Structural analyses of these compounds suggest a role for MELs in numerous cosmetic applications. MELs act as effective topical moisturizers and can repair damaged hair. Furthermore, these compounds have been shown to exhibit both protective and healing activities, to activate fibroblasts and papilla cells, and to act as natural antioxidants. In this review, we provide a brief summary of MEL research over the past few decades, focusing on the identification of MEL-producing fungi, the structural characterization of MELs, the use of alternative compounds as a primary carbon source, and the use of these compounds in cosmetic applications.
Research Institute for Innovation in Sustainable Chemistry, National Institute of Advanced Industrial Science and Technology (AIST).
Tomotake
T
Morita
Tokuma
T
Fukuoka
Tomohiro
T
Imura
Dai
D
Kitamoto
D000975:Antioxidants; D003358:Cosmetics; D019610:Cytoprotection / Q000187:drug effects; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006017:Glycolipids / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D012331:RNA, Fungal / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics; D017423:Sequence Analysis, RNA; D013501:Surface-Active Agents; D014587:Ustilaginales / Q000145:classification* / Q000235:genetics / Q000378:metabolism*
D000975:Antioxidants; D003358:Cosmetics; D006017:Glycolipids; D012331:RNA, Fungal; D012335:RNA, Ribosomal; D013501:Surface-Active Agents; C439671:mannosylerythritol lipid