Role of second-look ultrasound examinations for MR-detected lesions in patients with breast cancer.
OBJECTIVE
To assess the clinical value of second-look ultrasound (US) examination for the evaluation of additional enhancing lesions detected on magnetic resonance (MR) imaging.


METHODS
Between May 2008 and February 2011, 794 consecutive patients with histologically confirmed breast cancer underwent breast MR imaging. We included 101 patients with 132 additional enhancing breast lesions detected on MR imaging who underwent second-look US.  The imaging features and lesion category according to the Breast Imaging and Reporting and Data System (BI-RADS) were assessed with MR and US imaging, respectively.


RESULTS
According to the BI-RADS system, 67 lesions (50.8 %) were classified as category 0, 33 lesions (25.0 %) as category 3, and 32 lesions (24.2 %) as category 4. Of the 67 indeterminate lesions on MR imaging, 34 (50.7 %) were demonstrated on second-look US. 11 of these 34 lesions showed suspicious sonographic features, including 1 lesion that showed malignancy (9.1 %, 1/11). Most of the suspicious lesions on MR imaging (26 of 32 BI-RADS category 4 lesions, 81.3 %) were demonstrated on second-look US, and 17 were malignant (65.4 %, 17/26). Of the 6 BI-RADS category 4 lesions without sonographic correlation, 1 was malignant (16.7 %, 1/6).


CONCLUSIONS
Second-look US examination was useful for evaluating MR-detected lesions in patients with breast cancer.
Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea, Republic of.
S H
SH
Lee
Radiology, Seoul National University Bundang Hosipital, Seongnam, Korea, Republic of.
S M
SM
Kim
Radiology, Seoul National University Bundang Hosipital, Seongnam, Korea, Republic of.
M
M
Jang
Radiology, Seoul National University Bundang Hosipital, Seongnam, Korea, Republic of.
B L
BL
Yun
Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of.
E
E
Kang
Surgery, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of.
S W
SW
Kim
Pathology, Seoul National University Bundang Hospital, Seongnam-si, Korea, Republic of.
S Y
SY
Park
Radiology, Chung-Ang University Hospital, Seoul, Korea, Republic of.
H S
HS
Ahn
Department of Electronic Engineering, Sogang University, Seoul, Korea, Republic of.
J H
JH
Chang
Department of Electronic Engineering, Sogang University, Seoul, Korea, Republic of.
Y
Y
Yoo
Department of Electronic Engineering, Sogang University, Seoul, Korea, Republic of.
T K
TK
Song
Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea, Republic of.
W K
WK
Moon
D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D018275:Carcinoma, Lobular / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional; D016217:Ultrasonography, Mammary