Anakinra injection site reaction on FDG PET/CT.
Adult-onset Still's disease (AOSD) is a rare inflammatory disorder of unknown etiology, mainly characterized by fever, arthritis, skin rash, and raised ferritin concentration. FDG PET/CT scan of a 29-year-old woman with AOSD showed extensive lymphadenopathy, hypermetabolic splenomegaly, and increased bone marrow uptake consistent with AOSD activity. In addition, large dense lesions with high FDG uptake in the subcutaneous fat in the thighs corresponding to injection sites were seen. She had been treated with prednisone and daily subcutaneous injection of 100 mg anakinra before the scan indicating the subcutaneous lesions as injection site reactions to anakinra.
From the *Department of Radiology and Nuclear Medicine, and †Department of Internal Medicine and N4i Center for Immunodeficiency and Autoinflammation, Radboud University Medical Center, Nijmegen, the Netherlands.
Anne I J
AI
Arens
Dennis
D
Vriens
Marijn
M
Janssen
Anna
A
Simon
Wim J G
WJ
Oyen
D000210:Acute-Phase Reaction / Q000000981:diagnostic imaging* / Q000209:etiology; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007267:Injections; D053590:Interleukin 1 Receptor Antagonist Protein / Q000008:administration & dosage / Q000009:adverse effects*; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D016706:Still's Disease, Adult-Onset / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D053590:Interleukin 1 Receptor Antagonist Protein; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18