A novel approach to normal responder patient with repeated implantation failures--a case report.
We describe a case of normal responder patients with repeated implantation failure who was offered the combination of the ultrashort GnRH-ag/ GnRH-ant COH protocol, followed by endometrial injury and a subsequent natural cycle frozen-thawed embryos transfer. The patient conceived following the natural FET cycle that was supported by luteal daily progesterone, with the additional single injection of HCG and GnRH-agonist, on day of ET and 4 days later, respectively. This combined approach seems to be a valuable tool in the armamentarium for treating normal responder patients with repeated implantation failures and should be further examined in large randomized controlled trials.
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer) , Ramat Gan , Israel and.
Raoul
R
Orvieto
Masha
M
Brengauz
Baruch
B
Feldman
D000328:Adult; D002985:Clinical Protocols; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists* / Q000037:antagonists & inhibitors*; D006801:Humans
D007987:Gonadotropin-Releasing Hormone
Frozen-thawed embryo transfer; IVF outcome; local injury; mid-luteal GnRH-agonist; repeated implantation failures; ultrashort flare GnRH-agonist/GnRH antagonist