Highly stereoselective ruthenium(II)-catalyzed direct C2-syn-alkenylation of indoles with alkynes.
A carboamide-directed ruthenium-catalyzed C2-hydroindolation of alkynes has been described. This transformation provides a rapid access to free (N-H) C2-syn-alkenylated indole derivatives with the assistance of copper(II) salts, in which the directing group is removed via a one-pot process.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Wei
W
Zhang
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Jun
J
Wei
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Shaomin
S
Fu
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Dongen
D
Lin
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Huanfeng
H
Jiang
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
Wei
W
Zeng