Comparative anti-glycation and α-glucosidase inhibition studies of microbial transformed compounds of dydrogesterone.
Anti-glycation and α-glucosidase inhibition activities of microbial transformed compounds of dydrogesterone (1); 20R-hydroxy-9β,10αa-pregna-4,6-diene-3-one (2), 17β-hydroxy-9β,10α-androsta-4,6-diene-3-one (3) and 9β,10α-androsta-4,6-diene-3,17-dione (4) were evaluated. Compounds 1 and 4 showed potent α-glucosidase inhibitory activities, while 2 and 3 were found to be weak inhibitors, whereas anti-glycation activities of 1-4 were not observed.
Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan.
Azizuddin
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
Saima Rasheed
SR
Saima Rasheed
Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan.
Shaista
S
Naz
Department of Biotechnology, Jinnah University for Women, 5-C, Nazimabad, Karachi, Pakistan.
Suad
S
Naheed
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
Muhammad Iqbal
MI
Choudhary
D004394:Dydrogesterone / Q000494:pharmacology*; D005874:Gibberella / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D006031:Glycosylation / Q000187:drug effects; D012431:Rutin / Q000494:pharmacology
D065089:Glycoside Hydrolase Inhibitors; D012431:Rutin; D004394:Dydrogesterone