Adipose-derived stems cells and their role in human cancer development, growth, progression, and metastasis: a systematic review.
Obesity is a well recognized risk factor for several types of cancers, many of which occur solely or disproportionately in women. Adipose tissue is a rich source of adipose-derived stem cells (ASC), which have received attention for their role in cancer behavior. The purpose of this systematic review is to present the existing literature on the role of ASCs in the growth, development, progression, and metastasis of cancer, with an emphasis on malignancies that primarily affect women. To accomplish this goal, the bibliographic database PubMed was systematically searched for articles published between 2001 and 2014 that address ASCs' relationship to human cancer. Thirty-seven articles on ASCs' role in human cancer were reviewed. Literature suggests that ASCs exhibit cancer-promoting properties, influence/are influenced by the tumor microenvironment, promote angiogenesis, and may be associated with pathogenic processes through a variety of mechanisms, such as playing a role in hypoxic tumor microenvironment. ASCs appear to be important contributors to tumor behavior, but research in areas specific to women's cancers, specifically endometrial cancer, is scarce. Also, because obesity continues to be a major health concern, it is important to continue research in this area to improve understanding of the impact adiposity has on cancer incidence.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania. kyf4@pitt.edu.
Kyle E
KE
Freese
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Lauren
L
Kokai
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
Robert P
RP
Edwards
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
Brian J
BJ
Philips
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
M Aamir
MA
Sheikh
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
Joseph
J
Kelley
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania.
John
J
Comerci
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Kacey G
KG
Marra
Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania. McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
J Peter
JP
Rubin
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Research Institute, Pittsburgh, Pennsylvania. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania.
Faina
F
Linkov
D052436:Adipose Tissue, White / Q000166:cytology*; D050154:Adiposity; D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D063646:Carcinogenesis / Q000473:pathology*; D015687:Cell Hypoxia; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology; D012307:Risk Factors; D059016:Tumor Microenvironment