Oxytocin alleviates cisplatin-induced renal damage in rats.
OBJECTIVE
The purpose of the present study was to investigate the protective effect of oxytocin on cisplatin (CP)-induced renal damage in rats.


METHODS
Fourteen adult Sprague Dawley rats, weighing 200 to 210, were administered by cisplatin (CP, 2 mg/kg/day) twice a week for five weeks. Then, they were randomly divided into two groups and treated with either saline (1 ml/kg/day) or OT (200 µg/kg/day) for five weeks. Seven rats served as control group. At the end of the treatment period, animals were sacrificed and their kidneys were assessed histologically. In addition, C-reactive protein (CRP), TGF-β and Akt expression were evaluated immunohistochemically.


RESULTS
Both tubules and glomeruli were found to be severely damaged with marked medullary tubulo-interstitial inflammation due to chronic cisplatin exposure, particularly in the salinetreated group (Group 1) compared to control group. Oxytocin treatment spared renal-tissue significantly by suppressing CRP and TGF-β , and enhancing Akt expression.


CONCLUSIONS



CONCLUSIONS
We conclude that renal damage due to cisplatin toxicity was prevented to a great extent by the anti-inflammatory effect of oxytocin.
Gaziosmanpasa University Faculty of Medicine, Department of Physiology, Tokat Turkey.
Oytun
O
Erbas
Izmir Dr Behcet Uz Pediatric Medicine and Surgery Training and Research Hospital, Pediatric Endocrinology Clinic, Izmir, Turkey.
Huseyin
H
Anil Korkmaz
Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey.
Fatih
F
Oltulu
Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey.
Hüeyin
H
Aktug
Ege University School of Medicine, Department of Histology and Embryology, Izmir, Turkey.
Altug
A
Yavasoglu
Ege University School of Medicine, Department of Gynecology and Obstetrics, Izmir, Turkey.
Levent
L
Akman
Gaziosmanpasa University Faculty of Medicine, Department of Neurology, Tokat, Turkey.
Volkan
V
Solmaz
Ege University Faculty of Medicine, Department of Physiology, Izmir, Turkey.
Dilek
D
Taskiran
Akt; CRP; Cisplatin toxicity; Kidney; Oxytocin TGF-β