Enterovirus replication: go with the (counter)flow.
All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.
Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA.
Jules
J
Nchoutmboube
Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA.
Lauren A
LA
Ford-Siltz
Department of Veterinary Medicine and Virginia-Maryland Regional College of Veterinary, Medicine, University of Maryland, College Park, MD, USA. Electronic address: gbelov@umd.edu.
George A
GA
Belov
D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004770:Enterovirus / Q000502:physiology* / Q000648:ultrastructure; D006706:Homeostasis; D050356:Lipid Metabolism; D008055:Lipids / Q000096:biosynthesis; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010849:Picornaviridae / Q000502:physiology* / Q000648:ultrastructure; D011987:Receptors, Steroid / Q000378:metabolism; D012229:Rhinovirus / Q000502:physiology* / Q000648:ultrastructure; D014779:Virus Replication / Q000187:drug effects; D000098825:Oxysterol Binding Proteins
D008055:Lipids; D018129:Phosphatidylinositol Phosphates; D011987:Receptors, Steroid; D000098825:Oxysterol Binding Proteins; C037178:phosphatidylinositol 4-phosphate; D002784:Cholesterol
cholesterol–PI4P exchange; drug repurposing; enterovirus replication organelles; lipid trafficking; oxysterol binding protein (OSBP)