[4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes with simple olefins: facile approaches to tetrahydropyridazines.
A catalyst-free [4 + 2] annulation process between in situ generated 1,2-diaza-1,3-butadienes and simple olefins has been developed. Under mild conditions, the reactions afforded 1,4,5,6-tetrahydropyridazines, which feature a wide range of bioactive compounds, with high yields (up to 99% yield).
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Xingren
X
Zhong
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Jian
J
Lv
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.|Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
Sanzhong
S
Luo
D000475:Alkenes / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D002070:Butadienes / Q000737:chemistry*; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D001372:Aza Compounds; D001688:Biological Products; D002070:Butadienes; D011724:Pyridazines