Correlation of serum toll like receptor 9 and trace elements with lipid peroxidation in the patients of breast diseases.
Toll-like receptors are recognized as redox sensitive receptor proteins and have been implicated in cellular response to oxidative stress. Altered pro-oxidant-antioxidant balance leads to an increased oxidative damage and consequently play an important role in breast diseases. The study was designed to access the oxidative stress status by quantification of byproducts generated during lipid peroxidation and inadequate trace elements during oxidative damage and its effects on the toll like receptor (TLR) activity in patients of breast diseases. Decreased levels of selenium, copper, zinc, magnesium and iron with elevated levels of malondialdehyde (marker of lipid peroxidation) were accompanied by decreased TLR activity in patients of benign breast diseases as well as breast carcinoma. A similar pattern was observed with the advancement of disease and its subsequent progression in breast carcinoma patients. Results of multinomial regression analysis suggest benign breast disease patients are at higher risk of developing breast cancer with high odds ratio of lipid damage.
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Kanchan
K
Karki
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Deepti
D
Pande
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Reena
R
Negi
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Seema
S
Khanna
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
Ranjana S
RS
Khanna
Department of Biophysics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: hdkhanna@yahoo.co.in.
Hari D
HD
Khanna
D001941:Breast Diseases / Q000097:blood* / Q000473:pathology*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D012307:Risk Factors; D051217:Toll-Like Receptor 9 / Q000097:blood*; D014131:Trace Elements / Q000097:blood*
C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D014131:Trace Elements; D008315:Malondialdehyde
Copper; Iron; MDA; Magnesium; Selenium; TLR-9; Zinc