The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU).
The proinflammatory and pathogenic function of Th17 cells in autoimmune diseases have been established but the mechanism by which such cells cause disease remains to be determined. Inflammatory cytokines produced by Th17 cells may either promote or inhibit disease development. The major cytokines produced by the uveitogenic T cells, such as IL-17 and IL-22, are not always pathogenic, and the disease-inducing ability of pathogenic T cells is not immediately correlated to the amount of cytokine they produce. Future studies identifying factors causing increased Th17 responses and determining the types of cells that regulating Th17 autoreactive T cells should facilitate our effort of understanding Th17-mediated disease pathogenesis.
Doheny Eye Institute, and Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles (UCLA), 1355 San Pablo Street, Los Angeles, CA 90033, USA. Electronic address: dsun@doheny.org.
Deming
D
Sun
Doheny Eye Institute, and Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles (UCLA), 1355 San Pablo Street, Los Angeles, CA 90033, USA.
Dongchun
D
Liang
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA.
Henry J
HJ
Kaplan
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA.
Hui
H
Shao
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D053759:Interleukin-23 / Q000276:immunology; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*; D014605:Uveitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D000097043:Interleukin-22
D053759:Interleukin-23; D007378:Interleukins; D000097043:Interleukin-22
Autoimmune disease; EAU; Immunoregulation; Interleukin-17