Four-Dimensional Speckle Tracking Echocardiography in Patients with Hypertrophic Cardiomyopathy.
OBJECTIVE
Abnormal left ventricular (LV) deformational mechanics have been demonstrated in patients with hypertrophic cardiomyopathy (HCM) using two-dimensional (2D) speckle tracking echocardiography, but there is not enough information about the four-dimensional speckle tracking echocardiography (4DSTE) in these patients. The objective of the study was to identify and quantify the left ventricular contractility in patients with HCM using 4DSTE.


METHODS
Thirty patients [age, 54.6 ± 12.1 years; 12 (40%) women] with diagnosis of nonobstructive HCM and 20 healthy controls [age, 47.42 ± 11.43 years; 8 (40%) women] underwent 4DSTE measurement of longitudinal, radial, circumferential, and area strains.


RESULTS
Patients with HCM showed lower longitudinal (-13.5% vs. -20.3%, P < 0.001) and radial (33.4% vs. 43.6%, P < 0.001) strain, but higher circumferential (-22.7% vs. -15.9%, P < 0.001) and area (-30.7% vs. -22.1%, P < 0.001) strain than control subjects. Peak LV twist showed significantly higher values in patients with HCM (13.7 ± 5.3 vs. 11.3 ± 4.8, P < 0.005).


CONCLUSIONS
Patients with HCM have reduced longitudinal and radial strain but increased circumferential and area strain on 4DSTE. These results are found appropriate with previous 2DSTE studies. Thus, 4DSTE is useful to determine LV deformational mechanics.
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
Kadriye
K
Orta Kilickesmez
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
Onur
O
Baydar
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
Cem
C
Bostan
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
Ugur
U
Coskun
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
Serdar
S
Kucukoglu
D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D019561:Echocardiography, Four-Dimensional; D019560:Echocardiography, Three-Dimensional; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology
echocardiography; four-dimensional; hypertrophic cardiomyopathy; speckle tracking