Seeing is saving: the benefit of 3D imaging in gynecologic brachytherapy.
Despite a concerning decline in the use of brachytherapy over the past decade, no other therapy is able to deliver a very high dose of radiation into or near a tumor, with a rapid fall-off of dose to adjacent structures. Compared to traditional X-ray-based brachytherapy that relies on points, the use of CT and MR for 3D planning of gynecologic brachytherapy provides a much more accurate volume-based calculation of dose to an image-defined tumor and to the bladder, rectum, sigmoid, and other pelvic organs at risk (OAR) for radiation complications. The publication of standardized guidelines and an online contouring teaching atlas for performing 3D image-based brachytherapy has created a universal platform for communication and training. This has resulted in a uniform approach to using image-guided brachytherapy for treatment and an internationally accepted format for reporting clinical outcomes. Significant improvements in survival and reductions in toxicity have been reported with the addition of image guidance to increase dose to tumor and decrease dose to the critical OAR. Future improvements in individualizing patient treatments should include a more precise definition of the target. This will allow dose modulation based on the amount of residual disease visualized on images obtained at the time of brachytherapy.
Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, 75 Francis Street L2, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aviswanathan@lroc.harvard.edu.
Akila N
AN
Viswanathan
Department of Radiation Oncology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53266, USA. Electronic address: berickson@mcw.edu.
Beth A
BA
Erickson
D001918:Brachytherapy / Q000379:methods*; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*
Brachytherapy; CT; Cervical cancer; Image-guidance; MRI