Association of Enterovirus 71 encephalitis with the interleukin-8 gene region in Chinese children.
The study was performed in 36 Chinese patients with Enterovirus 71 (EV71) encephalitis and 141 patients with EV71-related hand, foot and mouth disease (HFMD) without encephalitis. Genotyping was determined by polymerase chain reaction- restriction fragment length polymorphism. Patients with EV71 encephalitis had a significantly higher frequency of interleukin-8 (IL-8)-251TT genotype than patients with EV71-related HFMD without encephalitis (55.6% vs 31.2%, p = 0.023). The frequency of IL-8-251T alleles was significantly higher among patients with EV71 encephalitis than in patients with EV71-related HFMD without encephalitis (72.2% vs 58.9%, odds ratio 1.8, 95% confidence interval 1.0-3.2, p = 0.038). There were significant differences in gender, age, fever days, white blood cell count, C-reactive protein and blood glucose concentration and IL-8 levels among genotypes of IL-8-251A/T in EV71-infected patients, but no significant differences in alanine or aspartate aminotransferase, creatine kinase-myocardial isozyme and cerebrospinal fluid in patients with EV71 encephalitis. These findings suggest that the IL-8-251T allele is associated with susceptibility to EV71 encephalitis in Chinese patients.
From the 1 Infectious Diseases Department, Qilu Children's Hospital of Shandong University , Jinan , PR China.
Jian
J
Li
Aiwei
A
Lin
Chengwen
C
Yu
Zhaofang
Z
Zhang
Daoyan
D
Xu
Wei
W
Hu
Liyan
L
Liu
Shaoning
S
Wang
Xiuzhen
X
Nie
Wenhui
W
Sun
Zhongtao
Z
Gai
Zongbo
Z
Chen
D000483:Alleles; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D018792:Encephalitis, Viral / Q000235:genetics* / Q000276:immunology; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000235:genetics* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000097:blood / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D019562:Viral Load
D001786:Blood Glucose; C508606:CXCL8 protein, human; D016209:Interleukin-8; D002097:C-Reactive Protein
Enterovirus 71 encephalitis; IL-8-251A/T; polymorphism