Superselective intra-arterial chemotherapy for advanced retinoblastoma complicated by metastatic disease.
We present a case of a child with unilateral group E retinoblastoma (according to the International Classification of Retinoblastoma) who received superselective intra-arterial chemotherapy as primary therapy. Although the tumor showed signs of regression, the patient developed orbital metastases requiring surgical excision and chemotherapy. Eventually the affected eye progressed to total retinal detachment and required enucleation.
Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia. Electronic address: mathewaanu@gmail.com.
Anu A
AA
Mathew
Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia.
Nisha
N
Sachdev
Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Victoria, Australia.
Sandra E
SE
Staffieri
Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia.
John D
JD
McKenzie
Department of Ophthalmology, Royal Children's Hospital, Melbourne, Victoria, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia.
James E
JE
Elder
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D015353:Eye Enucleation; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D033401:Microscopy, Acoustic; D009918:Orbital Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012175:Retinoblastoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D016190:Carboplatin