A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.
Department of Chemistry, University College London, 20 Gordon Street, London, UK. VPEnterprise@ucl.ac.uk.
Rachel E
RE
Morgan
Vijay
V
Chudasama
Paul
P
Moody
Mark E B
ME
Smith
Stephen
S
Caddick
D001966:Bromine / Q000737:chemistry; D008301:Maleimides / Q000737:chemistry; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D011724:Pyridazines / Q000737:chemistry; D025801:Ubiquitin / Q000737:chemistry* / Q000378:metabolism; D054875:Ubiquitination
D008301:Maleimides; D011724:Pyridazines; D025801:Ubiquitin; C043592:maleimide; C062482:pyridazine; D001966:Bromine