Frey syndrome: factors influencing the time to event.
Frey syndrome is a common complication after parotidectomy. The time from surgery to disease onset may be quite long; therefore, a time-to-event analysis was performed for the occurrence of this syndrome post-parotidectomy. Three hundred and thirty-four patients who underwent a parotidectomy between January 2002 and November 2012 were identified (retrospective study). Of these patients, 102 developed Frey syndrome post-surgery and 232 did not. The time-to-onset analysis enabled us to estimate the risk ratio associated with different types of parotid gland tumours, various parotidectomy procedures, and repeat parotidectomy, which is useful for predicting preoperative and surgical risk. The risk of developing Frey syndrome was lower in patients with malignant tumours than in those with benign tumours (risk ratio 0.351, 95% confidence interval (CI) 0.155-0.594). Risk ratios for lumpectomy PA (pre-auricular area), superficial parotidectomy, and total parotidectomy with respect to lumpectomy T (tail) were 4.378 (95% CI 1.168-16.410), 8.040 (95% CI 3.286-19.670), and 8.174 (95% CI 3.076-21.723), respectively. Repeat parotidectomy also increased the risk of developing Frey syndrome (risk ratio 3.214, 95% CI 1.547-6.678). No effect of the use of a superficial muscular aponeurotic system (SMAS) flap on the risk of developing Frey syndrome was detected (P=0.888).
Service of Oral and Maxillofacial Surgery, University Hospital Miguel Servet, Isabel la Católica, Zaragoza, Spain.
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M
Lafont
Department of Animal Medicine and Surgery, Universidad de Zaragoza, Zaragoza, Spain.
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A
Whyte
Department of Human Anatomy and Histology, Universidad de Zaragoza, Zaragoza, Spain.
J
J
Whyte
Service of Oral and Maxillofacial Surgery, University Hospital Miguel Servet, Isabel la Católica, Zaragoza, Spain.
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E
Saura
Department of Anatomy, Embryology and Animal Genetics, Universidad de Zaragoza, Zaragoza, Spain. Electronic address: ttejedor@unizar.es.
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MT
Tejedor
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D013547:Sweating, Gustatory / Q000209:etiology*; D013997:Time Factors
Frey syndrome; parotidectomy; risk ratio; survival analysis