Fighting an old disease with next-generation sequencing.
Whole genome sequencing has revealed that most cases of tuberculosis in a high-incidence setting in Malawi were caused by just one lineage of the bacterium responsible for the disease.
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for TB Research and the Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa.
Anzaan
A
Dippenaar
DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for TB Research and the Division of Molecular Biology and Human Genetics, Stellenbosch University, Stellenbosch, South Africa rw1@sun.ac.za.
Robin M
RM
Warren
D005798:Genes, Bacterial; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics; D014376:Tuberculosis / Q000235:genetics / Q000382:microbiology*
Malawi; epidemiology; global health; transmission; tuberculosis