Imbalance of circulating lymphoid cells in Q fever endocarditis.
Q fever endocarditis is characterized by a defective cell-mediated immune response, which may be associated with the dysregulation of circulating subsets of immune cells. In this study, we found that naïve CD8(+) T lymphocytes and CD56dim natural killer cells were decreased patients whereas central memory CD8(+) T lymphocytes were increased. It is likely that these different subsets of immune cells play a role in the immunosuppression accompanying Q fever endocarditis.
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France mignouk@yahoo.fr.
Mignane B
MB
Ka
Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
Françoise
F
Gondois-Rey
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France.
Eric
E
Ghigo
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France.
Didier
D
Raoult
Inserm UMR 1068, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
Daniel
D
Olive
Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UMR 63, CNRS 7278, IRD 198, INSERM U1095, Marseille, France.
Jean-Louis
JL
Mege
D000368:Aged; D000369:Aged, 80 and over; D001769:Blood / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004697:Endocarditis, Bacterial / Q000276:immunology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011778:Q Fever / Q000276:immunology*
Q fever; endocarditis; flow cytometry; lymphoid compartment