Antibacterial, cytotoxicity and anticoagulant activities from Hypnea esperi and Caulerpa prolifera marine algae.
Extracts from 2 algal species (Hypnea esperi and Caulerpa prolifera) from Suez Canal region, Egypt were screened for the production of antibacterial compounds against some pathogenic bacteria. The bacteria tested included Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Aeromonas hydrophila, Bacillus subtilis and Staphylococcus aureus. Algal species displayed antibacterial activity. The methanolic extracts showed variable response by producing various zones of inhibition against studied bacteria. The tested Gram-negative bacteria were less affected by studied algal extracts than Gram-positive bacteria. We determined some biopotentials properties such as cytotoxicity and anticoagulant activity of most potent algal active extracts. The secondary metabolites of only Hypnea esperi algal extract effectively prevented the blood clotting to the extent of 120 seconds. Minimum inhibitory concentration (MIC) indicated that all potent tested algal extract C inhibits Bacillus subtilis and Staphylococcus aureus. Minimum bactericidal concentration (MBC) was between 1 and 1.4mg/ml. The algal isolates from Egypt have been found showing promising results against infectious bacteria instead of some synthetic antibiotics.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Aljouf University, Saudi Arabia / Microbiology and Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Samy
S
Selim
Microbiology and Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt / Biology Department, Faculty of Science and Arts Khulais, King AbdulAziz University, KSA.
Abeer
A
Amin
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Aljouf University, Saudi Arabia / Faculty of Science, Botany Department, Beni Suef University, Egypt.
Sherif
S
Hassan
Marine Science Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
Mohamed
M
Hagazey
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D000925:Anticoagulants / Q000494:pharmacology* / Q000633:toxicity; D001156:Artemia; D046068:Caulerpa; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D000461:Rhodophyta
D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D010936:Plant Extracts