Correlation of hyperinsulinemia with hyperandrogenemia in primary infertile women with polycystic ovary syndrome.
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among women of the reproductive age and is the most common form of anovulatory infertility. Hyperinsulinemia and hyperandrogenemia are the characteristic features of PCOS, but the association between hyperinsulinemia and hyperandrogenemia is not well established. To find out any causal association between Hyperinsulinemia and hyperandrogenemia, a retrospective study was done on primary infertile women suffering from PCOS in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University. A total of 80 subjects were selected, among them 60 were cases and 20 were controls. Depending on their body mass index, the cases were divide into two groups, obese (n=30) and non-obese (n=30). Age and BMI matched controls were taken for both age groups. Observations derived from the study suggested that hyperinsulinemia and hyperandrogenemia are characteristic features of PCOS but significant correlation was not found between hyperinsulinemia and hyperandrogenemia. However, we cannot negate any possible association between the two and thereby we recommend further study to be done with a larger sample size.
Dr Laila Mahzabeen Banu, Associate Professor, Department of Biochemistry, East-West Medical College, Dhaka, Bangladesh.
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Banu
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Begum
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Rahman
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Mollah
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Ferdousi
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Habibullah
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D007247:Infertility, Female / Q000097:blood*; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012189:Retrospective Studies; D013739:Testosterone / Q000097:blood*
D001786:Blood Glucose; D007328:Insulin; D013739:Testosterone