Fate by RNA methylation: m6A steers stem cell pluripotency.
The N 6-methyladenosine (m6A) modification of mRNA has a crucial function in regulating pluripotency in murine stem cells: it facilitates resolution of naïve pluripotency towards differentiation.
Boxuan Simen
BS
Zhao
Chuan
C
He
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D008745:Methylation; D051379:Mice; D010641:Phenotype; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
D012333:RNA, Messenger; C010223:N-methyladenosine; D000241:Adenosine