No impact of passive smoke on the somatic profile of lung cancers in never-smokers.
EGFR and HER2 mutations and ALK rearrangement are known to be related to lung cancer in never-smokers, while KRAS, BRAF and PIK3CA mutations are typically observed among smokers. There is still debate surrounding whether never-smokers exposed to passive smoke exhibit a "smoker-like" somatic profile compared with unexposed never-smokers. Passive smoke exposure was assessed in the French BioCAST/IFCT-1002 never-smoker lung cancer cohort and routine molecular profiles analyses were compiled. Of the 384 patients recruited into BioCAST, 319 were tested for at least one biomarker and provided data relating to passive smoking. Overall, 219 (66%) reported having been exposed to passive smoking. No significant difference was observed between mutation frequency and passive smoke exposure (EGFR mutation: 46% in never exposed versus 41% in ever exposed; KRAS: 7% versus 7%; ALK: 13% versus 11%; HER2: 4% versus 5%; BRAF: 6% versus 5%; PIK3CA: 4% versus 2%). We observed a nonsignificant trend for a negative association between EGFR mutation and cumulative duration of passive smoke exposure. No association was found for other biomarkers. There is no clear association between passive smoke exposure and somatic profile in lifelong, never-smoker lung cancer.
For a list of the authors' affiliations see the Acknowledgements section.
Sébastien
S
Couraud
For a list of the authors' affiliations see the Acknowledgements section.
Didier
D
Debieuvre
For a list of the authors' affiliations see the Acknowledgements section.
Lionel
L
Moreau
For a list of the authors' affiliations see the Acknowledgements section.
Patrick
P
Dumont
For a list of the authors' affiliations see the Acknowledgements section.
Jacques
J
Margery
For a list of the authors' affiliations see the Acknowledgements section.
Elisabeth
E
Quoix
For a list of the authors' affiliations see the Acknowledgements section.
Bernard
B
Duvert
For a list of the authors' affiliations see the Acknowledgements section.
Laurent
L
Cellerin
For a list of the authors' affiliations see the Acknowledgements section.
Nathalie
N
Baize
For a list of the authors' affiliations see the Acknowledgements section.
Bruno
B
Taviot
For a list of the authors' affiliations see the Acknowledgements section.
Marie
M
Coudurier
For a list of the authors' affiliations see the Acknowledgements section.
Jacques
J
Cadranel
For a list of the authors' affiliations see the Acknowledgements section.
Pascale
P
Missy
For a list of the authors' affiliations see the Acknowledgements section.
Franck
F
Morin
For a list of the authors' affiliations see the Acknowledgements section.
Jean-François
JF
Mornex
For a list of the authors' affiliations see the Acknowledgements section.
Gérard
G
Zalcman
Pierre-Jean
PJ
Souquet
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics; D000368:Aged; D000077548:Anaplastic Lymphoma Kinase; D015415:Biomarkers; D058534:Class I Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005602:France; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D011446:Prospective Studies; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D012907:Smoking; D011795:Surveys and Questionnaires; D014028:Tobacco Smoke Pollution
D000077548:Anaplastic Lymphoma Kinase; D015415:Biomarkers; D058534:Class I Phosphatidylinositol 3-Kinases; D066246:ErbB Receptors; D019869:Phosphatidylinositol 3-Kinases; D048493:Proto-Oncogene Proteins B-raf; D016283:Proto-Oncogene Proteins p21(ras); D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D014028:Tobacco Smoke Pollution; C117307:KRAS protein, human; C484760:PIK3CA protein, human; C000626173:ALK protein, human; C512478:EGFR protein, human; C508053:ERBB2 protein, human; C482119:BRAF protein, human