Detection and characterization of nanoparticles in suspension at low concentrations using the X-ray total scattering pair distribution function technique.
Difference atomic pair distribution function methods have been applied to detect and characterize nanoparticles suspended in a solvent at very dilute concentrations. We specifically consider nanoparticles of a pharmaceutical compound in aqueous solution using X-ray PDF methods, a challenging case due to the low atomic number of the nanoparticle species. The nanoparticles were unambiguously detected at the level of 0.25 wt%. Even at these low concentrations the signals were highly reproducible, allowing for reliable detection and quantitative analysis of the nanoparticle structure.
Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY 10027, USA.
Maxwell W
MW
Terban
Matthew
M
Johnson
Marco
M
Di Michiel
Simon J L
SJ
Billinge