Association of XRCC1 polymorphisms with arsenic methylation.
The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMA(V)) and lower dimethylarsinic acid (DMA(V))/MMA(V) ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.
Department of Legal Medicine, Shimane University School of Medicine, Izumo, 693-8501, Japan. jfujihar@med.shimane-u.ac.jp.
Junko
J
Fujihara
Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui, Japan.
Toshihiro
T
Yasuda
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, 790-8577, Japan.
Hisato
H
Iwata
Center for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama, 790-8577, Japan.
Shinsuke
S
Tanabe
Department of Legal Medicine, Shimane University School of Medicine, Izumo, 693-8501, Japan.
Haruo
H
Takeshita
D000080242:8-Hydroxy-2'-Deoxyguanosine; D001151:Arsenic / Q000378:metabolism* / Q000493:pharmacokinetics; D044466:Asian People / Q000235:genetics; D002101:Cacodylic Acid / Q000652:urine; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D006801:Humans; D008745:Methylation; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002101:Cacodylic Acid; D003849:Deoxyguanosine; D001151:Arsenic
8-Hydroxy-2′-deoxyguanosine (8-OHdG); Arsenic compounds; Base excision repair (BER); Single nucleotide polymorphisms (SNPs); X-ray repair cross-complementing group 1 (XRCC1)