Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours: part 1. Proliferation, apoptosis and DNA repair.
There have been significant recent advances in the understanding of the molecular events and critical pathways associated with and driving cancer of the mammary gland in humans and dogs. The study of canine mammary tumour biology, particularly of the molecular events associated with proliferation, cell survival, invasion and metastasis, is crucial for the development of effective therapeutic agents and strategies. In this first part of a two-part review, recent advances in the understanding of the clinically relevant genetic and molecular pathways driving cell proliferation, apoptosis and DNA repair in canine mammary gland tumours are described.
Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar (ICBAS), University of Porto, Porto, Portugal; Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute (CECA/ICETA), University of Porto, Porto, Portugal. Electronic address: ajmatos@icbas.up.pt.
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Matos
Faculty of Veterinary Medicine of University Lusófona of Humanities and Technologies, Lisbon, Portugal; Research Centre for Biosciences and Health Technologies (CBIOS), Lisbon, Portugal.
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Santos
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D049109:Cell Proliferation; D004260:DNA Repair / Q000235:genetics*; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D015674:Mammary Neoplasms, Animal / Q000235:genetics*
Cell cycle; Dog; Genetic pathways; Mammary tumour; Molecular pathways