Study of the Influence of Bone Cement Type and Mixing Method on the Bioactivity and the Elution Kinetics of Ciprofloxacin.
The objectives of this study were to examine ciprofloxacin release from three trademarks of bone cements (Simplex®, Lima® and Palacos®) and its bioactivity using as variables, the mixing method, the chemical form of the antibiotic and the antibiotic combination. The antibiotic amount released in base form represents 35% of antibiotic amount released when hydrochloride form is incorporated. Moreover, the combination (vancomycin and ciprofloxacin) shows a stronger release (132%) than hydrochloride ciprofloxacin alone. Three cements show equal drug release profile (P > 0.05). A bioactivity simulation exercise showed that until 72 hours post-surgery, ciprofloxacin concentrations in the implant would be higher than 0.1 μg/mL in 100% of the patients. After drain removal, it is expected that bioactivity would increase since drug clearance from implant would decrease.
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia, Spain; Servicio de Farmacia, Hospital Universitario Doctor Peset de Valencia, Spain.
Javier
J
Martínez-Moreno
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia, Spain.
Carla
C
Mura
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia, Spain.
Virginia
V
Merino
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia, Spain.
Amparo
A
Nácher
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Servicio de Farmacia, Hospital Universitario Doctor Peset de Valencia, Spain.
Mónica
M
Climente
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Valencia, Spain; Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia-Universidad de Valencia, Spain.
Matilde
M
Merino-Sanjuán
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements / Q000737:chemistry*; D002939:Ciprofloxacin / Q000008:administration & dosage*; D004338:Drug Combinations; D016503:Drug Delivery Systems; D006801:Humans; D007700:Kinetics; D008768:Methylmethacrylates / Q000737:chemistry; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012995:Solubility; D013696:Temperature; D014640:Vancomycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004338:Drug Combinations; D008768:Methylmethacrylates; D011137:Polystyrenes; C032043:styrene-methylmethacrylate copolymer; D002939:Ciprofloxacin; D014640:Vancomycin; D019904:Polymethyl Methacrylate
PMMA; bioactivity; bone cement; ciprofloxacin; elution kinetics; orthopedics