A natural choice for hemophilia B.
In this issue of Blood, Crudele et al describe a novel study of adeno-associated virus (AAV) vector-mediated gene therapy that induced immune tolerance to factor IX (FIX) in a hemophilia B (HB) dog with previously formed anti-FIX inhibitor antibodies (IAs).
DUKE UNIVERSITY MEDICAL CENTER; DEPARTMENT OF MOLECULAR GENETICS AND MICROBIOLOGY, DUKE UNIVERSITY.
Dwight D
DD
Koeberl
D000818:Animals; D005164:Factor IX / Q000037:antagonists & inhibitors*; D015316:Genetic Therapy / Q000379:methods*; D002836:Hemophilia B / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D008297:Male
D005164:Factor IX