Sputum and BAL Clara cell secretory protein and surfactant protein D levels in asthma.
Clara cell secretory protein (CC16) is associated with Th2 modulation. Surfactant protein D (SPD) plays an important role in surfactant homeostasis and eosinophil chemotaxis. We measured CC16 and SPD in sputum supernatants of 84 asthmatic patients and 12 healthy controls. In 22 asthmatics, we additionally measured CC16 and SPD levels in BAL and assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detachment (ED) in bronchial biopsies. Induced sputum CC16 and SPD were significantly higher in patients with severe asthma (SRA) compared to mild-moderate and healthy controls. BAL CC16 and SPD levels were also higher in SRA compared to mild-moderate asthma. CC16 BAL levels correlated with ED, while SPD BAL levels correlated with SMA and RBM. Severity represented a significant covariate for these associations. CC16 and SPD levels are upregulated in SRA and correlate with remodeling indices, suggesting a possible role of these biomarkers in the remodeling process.
1st Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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Emmanouil
2nd Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Attikon' Hospital, Athens, Greece.
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S
Loukides
2nd Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Attikon' Hospital, Athens, Greece.
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K
Kostikas
Research Unit, 401 General Army Hospital, Athens, Greece.
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G
Papatheodorou
1st Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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A
Papaporfyriou
1st Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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G
Hillas
Pathology Department, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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I
Vamvakaris
Pathology Department, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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R
Triggidou
Pathology Department, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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P
Katafigiotis
Cytology Department, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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A
Kokkini
2nd Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Attikon' Hospital, Athens, Greece.
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S
Papiris
1st Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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N
Koulouris
1st Department of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, 'Sotiria' Hospital of Chest Diseases, Athens, Greece.
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Bakakos
D001249:Asthma / Q000276:immunology / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D001980:Bronchi / Q000473:pathology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D016022:Case-Control Studies; D006801:Humans; D009130:Muscle, Smooth / Q000473:pathology; D037663:Pulmonary Surfactant-Associated Protein D / Q000276:immunology*; D020545:Respiratory Mucosa / Q000473:pathology; D012720:Severity of Illness Index; D013183:Sputum / Q000276:immunology*; D014598:Uteroglobin / Q000276:immunology*
D037663:Pulmonary Surfactant-Associated Protein D; C556389:SCGB1A1 protein, human; D014598:Uteroglobin
asthma; clinical immunology; remodelling