Disseminated Mycobacterium gordonae and Mycobacterium mantenii infection with elevated anti-IFN-γ neutralizing autoantibodies.
A case of disseminated nontuberculous mycobacteria(l) (NTM) infection in a patient with positive neutralizing anti-interferon-γ (IFN-γ) autoantibodies involving bone, bronchus, systemic lymph nodes, and skin is reported. The causative NTMs were two different strains: Mycobacterium gordonae, which rarely causes true disease, and Mycobacterium mantenii, which is extremely rare. Anti-mycobacterial treatment successfully ameliorated all disseminated lesions. Although the concentration of anti-IFN-γ autoantibodies increased during the pre-treatment period, it gradually decreased after anti-mycobacterial treatment was started.
Department of Respiratory Disease, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama-shi, Fukushima 963-8563, Japan; Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan. Electronic address: i-hase@dokkyomed.ac.jp.
Isano
I
Hase
Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-0022, Japan.
Kozo
K
Morimoto
Division of Respiratory Medicine and Infectious Disease, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata-shi, Niigata 951-8510, Japan.
Takuro
T
Sakagami
Molecular Epidemiology and Genetic Identification Division, Department of Mycobacteria References and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan.
Yuko
Y
Kazumi
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan.
Yoshiki
Y
Ishii
Department of Medical Microbiology, Radboud University Medical Center, P.O. Box 9101, 6500HB Nijmegen, The Netherlands.
Jakko
J
van Ingen
D000368:Aged; D057134:Antibodies, Neutralizing / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D008297:Male; D009165:Mycobacterium Infections, Nontuberculous / Q000276:immunology*; D009170:Nontuberculous Mycobacteria / Q000276:immunology*
D057134:Antibodies, Neutralizing; D001323:Autoantibodies; D007371:Interferon-gamma
Anti-IFN-γ neutralizing autoantibodies; Disseminated nontuberculous mycobacterium infection; Mycobacterium gordonae; Mycobacterium mantenii