Multilevel BCR signals toward CLL.
In this issue of Blood, Iacovelli et al provide the first in vivo experimental evidence on the proleukemogenic relevance of autonomous (exo-antigen–independent) B-cell receptor (BCR) stimulation in conjunction with ligand (autoantigen)- mediated BCR signaling in chronic lymphocytic leukemia (CLL).
UNIVERSITY OF COLOGNE.
Marco
M
Herling
UNIVERSITY OF COLOGNE.
Elena
E
Vasyutina
D000818:Animals; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology* / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D011947:Receptors, Antigen, B-Cell