Utility of Heart-type Fatty Acid Binding Protein as a New Biochemical Marker for the Early Diagnosis of Acute Coronary Syndrome.
BACKGROUND
Acute coronary syndrome (ACS) refers to a constellation of clinical symptoms caused by acute myocardial ischemia. Cardiovascular diseases (CVDs) are major and growing contributors to mortality and disability in India.


OBJECTIVE
Especially patients with non-ACS-related troponin elevations have an adverse outcome and require careful patient management. So, we look forward for another marker Heart-type Fatty Acid Binding Protein (H-FABP) that reliably detects myocardial ischemia in the absence of necrosis and would be useful for initial identification and for differentiating patients with chest pain of aetiology other than coronary ischemia.


METHODS
The study was done on 88 subjects of whom 34 subjects were with ischemic chest pain, 29 were with non-ischemic chest pain and 25 were normal subjects.


RESULTS
Receiver operating characteristic (ROC) curve analysis was done which showed that area under the curve (AUC) for H-FABP was 0.885(0.79-0.94) and that of high-sensitive Troponin T (hs-TnT) in initial six hours was 0.805(0.70-0.88). The specificity of H-FABP was higher compare to hs-TnT while sensitivity was comparable during 0-6 h of presentation of chest pain.


CONCLUSIONS
H-FABP can be used as an additional marker to hs-TnT in diagnosis of myocardial infarction (MI) and for exclusion of non-AMI (acute myocardial infarction) patients.
Assistant Professor, Department of Biochemistry, Advance Institute of Medical Science , Bhopal, India .
Bhakti N
BN
Gami
Assistant Professor, Department of Biochemistry, Gujarat Adani Institute of Medical Sciences (GAIMS) , Bhuj, Gujarat, India .
Dharmik S
DS
Patel
Professor and Head, Department of Biochemistry, Pramukhswami Medical College , Karamsad, Gujarat, India .
N
N
Haridas
Associate Professor, Department of Biochemistry, GMERS Medical College , Gandhinagar, India .
Kiran P
KP
Chauhan
Professor, Department of Biochemistry, Pramukhswami Medical College , Karamsad, Gujarat, India .
Hitesh
H
Shah
Assistant Professor, Department of Biochemistry, Pramukhswami Medical College , Karamsad, Gujarat, India .
Amit
A
Trivedi
Biomarker; High sensitive troponin T; Myocardial infarction