Relationship between serum leptin levels and bone mineral density: a systematic review and meta-analysis.
BACKGROUND
The association between leptin and bone mineral density (BMD) is controversial because of conflicting findings from previous studies.


METHODS
This meta-analysis aimed to provide an overview of the serum leptin levels and BMD in a healthy population. We reviewed the PubMed, Embase, and Cochrane Library databases until July 2014 for research on the association between leptin levels and BMD in healthy people.


RESULTS
We included and analyzed 45 studies in this systematic review and meta-analysis. The pooled correlations between leptin and BMD were analyzed by using the method of the inverse of the variance. Leptin was positively associated with BMD and the bone mineral content (BMC), especially in postmenopausal women (pooled r: 0.13-0.49). Overall, high serum leptin levels were associated with higher BMD levels.


CONCLUSIONS
This meta-analysis suggests that serum leptin levels are positively associated with BMD and BMC, especially in postmenopausal women.
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Kuan
K
Liu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Pengcheng
P
Liu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Run
R
Liu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: orthopedics_dsyy@126.com.
Xing
X
Wu
Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: cmdoctor@tongji.edu.cn.
Ming
M
Cai
D015519:Bone Density; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male
D020738:Leptin
Bone mineral content; Bone mineral density; Leptin; Menopausal status; Meta-analysis