Relationship between polymorphism of SOCS-3 and dyslipidemia in China Xinjiang Uygur.
We investigated the relationship between the polymorphism of SOCS-3 and dyslipidemia of people from Uygur in Xinjiang, China. This cross-sectional study included 1379 participants in a Hetian Xinjiang Uygur population who were 30-70 years of age and were not from interracial marriages of 3 generations; all subjects were genotyped (909 dyslipidemia subjects, 470 healthy subjects). Allele (P = 0.002) and genotype (P = 0.003) frequencies of the distribution of rs12953258 was significantly different between dyslipidemia and control groups. Between the total cholesterol abnormal and control groups, high-density lipoprotein cholesterol abnormal and control groups, triglycerides abnormal and control groups, the frequencies of genotype in rs12953258 were significantly different (P = 0.007, 0.012, 0.0004, respectively). Based on the logistic regression analysis, genotype CA and AA of rs12953258 were independent and risk factors for dyslipidemia in Uygur (CC vs CA; odds ratio = 1.48, 95% confidence interval = 1.11-1.98, P = 0.008), (CC vs AA; odds ratio = 2.48, 95% confidence interval1.07-5.79, P = 0.035). Genotype AA of rs12953258 merged with subjects whose waist-to-hip ratio was abnormal, indicating the presence of dyslipidemia. The frequency of haplotype 4(H4) A-G-C in the dyslipidemia group was higher than in the control group (8.44 vs 5.37%, P = 0.003). rs12953258 site of the SOCS-3 gene showed a close relationship with dyslipidemia in Uygur. Combining genotype AA with subjects whose waist-to-hip ratios were abnormal will increase prevalence of dyslipidemia obviously.
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Yao
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Meng
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Zhou
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Lin
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Hong
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
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Heizhati
Hypertension Institute of Xinjiang China, Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China lnanfang2010@sina.com.cn.
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Li
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000208:ethnology* / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
D008076:Cholesterol, HDL; C106644:SOCS3 protein, human; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D014280:Triglycerides