[The role of the prefrontal cortex in the sensory problems of children with autism spectrum disorder and its involvement in social aspects].
BACKGROUND
In persons with autism spectrum disorders (ASD), aberrant sensory perceptions could be as characteristic and disruptive as the presence of anomalies in social communication and interaction or restricted and repetitive interests. Most of them present sensory modulation disorders (hyper- or hypo-responsiveness) in several sensory channels. Furthermore, there is a deficit in the integration of the information from a number of sensory systems (for example, auditory and visual). All this would worsen the core symptoms related with communication and increase the appearance of behavioural problems.


OBJECTIVE
This study aims to review the experimental evidence that addresses the role played by the prefrontal cortex in unusual sensory experiences in ASD and its involvement in social aspects. There is evidence of hypoactivation and dysfunction of the neural networks, which include the prefrontal cortex and participate in social cognition, such as the default mode and the mirror neuron system in children with ASD.


CONCLUSIONS
Sensory-motor problems at an early age correspond to a disruption in the organisation and regulation not only of perception and action but also language, thought, emotion and even memory.
Universidad de Valencia, 46071 Valencia, Espana.
Sonia
S
Martínez-Sanchis
D000067877:Autism Spectrum Disorder / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D002648:Child; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012678:Sensation Disorders / Q000209:etiology*; D012920:Social Behavior Disorders / Q000209:etiology*