High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression.
The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, but this was based on 3 deaths only. Among 68 untreated patients, those with higher sCD14 levels had more rapid spontaneous CD4 cell decline during the first 18 months following primary infection. This association persisted after adjustment for age, the CD4 cell count, and HIV viral load at diagnosis.
INSERM, U1018, Epidemiology of HIV and STI, CESP; University Paris-Sud Department of Public Health and Epidemiology, Bicêtre Hospital, AP-HP.
Evguenia
E
Krastinova
INSERM 1012, Immune Response Regulation, HIV-1 and Autoimmunity, University Paris-Sud, Le Kremlin Bicêtre.
Camille
C
Lecuroux
INSERM 1012, Immune Response Regulation, HIV-1 and Autoimmunity, University Paris-Sud, Le Kremlin Bicêtre.
Carole
C
Leroy
INSERM, U1018, Epidemiology of HIV and STI, CESP; University Paris-Sud Department of Public Health and Epidemiology, Bicêtre Hospital, AP-HP.
Remonie
R
Seng
Department of Infectious and Tropical Diseases and INSERM CIE802, University Hospital of Fort-de-France, Martinique.
Andre
A
Cabie
Department of Internal Medicine, Lariboisiere Hospital, AP-HP, Paris.
Agathe
A
Rami
INSERM 1012, Immune Response Regulation, HIV-1 and Autoimmunity, University Paris-Sud, Le Kremlin Bicêtre.
Alain
A
Venet
INSERM, U1018, Epidemiology of HIV and STI, CESP; University Paris-Sud Department of Public Health and Epidemiology, Bicêtre Hospital, AP-HP.
Laurence
L
Meyer
INSERM, U1018, Epidemiology of HIV and STI, CESP; University Paris-Sud Department of Internal Medicine, Bicêtre Hospital, AP-HP, University Paris-Sud, Le Kremlin-Bicêtre, France.
Cecile
C
Goujard
D000328:Adult; D000368:Aged; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality* / Q000821:virology; D015497:HIV-1; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D019562:Viral Load
D044966:Anti-Retroviral Agents; D015415:Biomarkers; D018950:Lipopolysaccharide Receptors
HIV-1; immune activation; mortality; sCD14; systemic inflammation