[Haemostasis dysregulation in filovirus infections].
Filoviruses are responsible for highly lethal infections. Those viruses are found in intertropical areas of Africa and Asia where they circulate in their supposed natural reservoir, fruit bats. During filovirus outbreaks and depending on the strains, various modifications in hemostasis have been observed in patients. The disseminated intravascular coagulation identified in these infections is multicausal and involves both viral factors and abnormal physiological responses. In this review we will describe the mechanisms responsible for these disturbances and we will highlight some aspects of the basis of filovirus high pathogenicity.
CIRI (centre international de recherche en infectiologie), Inserm U1111, laboratoire bases moléculaires de la pathogénicité virale, 21, avenue Tony Garnier, 69007 Lyon, France.
Olivier
O
Reynard
CIRI (centre international de recherche en infectiologie), Inserm U1111, laboratoire bases moléculaires de la pathogénicité virale, 21, avenue Tony Garnier, 69007 Lyon, France.
Beatriz
B
Escudero-Perez
CIRI (centre international de recherche en infectiologie), Inserm U1111, laboratoire bases moléculaires de la pathogénicité virale, 21, avenue Tony Garnier, 69007 Lyon, France.
Viktor
V
Volchkov
D000302:Adrenal Cortex / Q000473:pathology; D000818:Animals; D002685:Chiroptera / Q000821:virology; D021821:Communicable Diseases, Emerging / Q000097:blood / Q000150:complications; D016207:Cytokines / Q000378:metabolism; D004197:Disease Reservoirs; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D042783:Endothelial Cells / Q000473:pathology; D016563:Filoviridae / Q000502:physiology; D018702:Filoviridae Infections / Q000097:blood* / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary / Q000821:virology; D000882:Haplorhini; D022781:Hepatocytes / Q000473:pathology; D054884:Host-Pathogen Interactions; D006801:Humans; D009336:Necrosis; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000502:physiology; D019562:Viral Load; D014764:Viral Proteins / Q000502:physiology
D016207:Cytokines; D011994:Recombinant Proteins; D014764:Viral Proteins; D013925:Thromboplastin