[Two cases of dural metastasis of breast cancer].
The first case of dural metastasis occurred in a 60s years old woman, who presented with bone metastasis to the right breast. Nine months later, disorientation and left hemiplegia developed, the right coronal bone metastasis enlarged, and dural metastases were detected close to the tumor, as observed by using cranial magnetic resonance imaging (MRI). Whole brain radiation and chemotherapy(weekly paclitaxel)were administered. The right coronal bone metastasis reduced remarkably, and the dural metastases almost disappeared, as observed on a cranial MRI scan. The second case of dural metastasis occurred in a 50s years old woman who presented with multiple bone metastases. Extensive bone metastases to the skull and dural metastases to the side of the head were observed on cranial MRI scans. Subsequently, the patient experienced a severe headache, and whole brain radiation and pharmacotherapy with anastrozole and trastuzumab were administered. Cranial MRI revealed that the skull bone metastasis reduced and the dural metastases almost disappeared. We report that radiotherapy and pharmacotherapy were effective in these 2 cases of dural metastases of breast cancer.
Dept. of Surgery, Japanese Red Cross Okayama Hospital.
Seiji
S
Yoshitomi
Hisashi
H
Tsuji
Yuko
Y
Abe
Kazuaki
K
Miyahara
Hajime
H
Kashima
Takeshi
T
Kurosaki
Masatoshi
M
Kuroda
Toshihisa
T
Yamano
Shoji
S
Takagi
Eiji
E
Ikeda
Ryuji
R
Hirai
Shigeharu
S
Moriyama
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D000077211:Zoledronic Acid
D000972:Antineoplastic Agents, Phytogenic; D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D017239:Paclitaxel