[Effect of embryonic anlage allografts of the rat spinal cord on growth of regenerating fibers of the recipient nerve].
A comparative study of the effect of tissue and suspension allografts of an embryonic spinal cord on regeneration of nerve fibers of impaired (by application of a ligature) sciatic nerve in rats was conducted. It was demonstrated that unlike tissue grafts that reach a large volume 21 and 60 days after transplantation, suspension grafts do not inhibit the growth of axons of the recipient to the periphery. It was established that introduction of a suspension of dissociated cells of the spinal cord embryonic anlages (but not fragments of these anlages) into the impaired sciatic nerve in rats results in an increase in the amount of myelinated regenerating nerve fibers of the recipient 60 days after the operation.
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Petrova
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Isaeva
D000818:Animals; D001369:Axons / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000637:transplantation* / Q000648:ultrastructure; D007150:Immunohistochemistry; D008026:Ligation; D009413:Nerve Fibers, Myelinated / Q000502:physiology* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000502:physiology*; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000473:pathology / Q000628:therapy*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000637:transplantation* / Q000648:ultrastructure