[Morphological changes in brain tissues of rat with local permanent ischemia model under the action of 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate].
The influence of 2-methyl-6-ethyl-3-hydroxypiridine hemisuccinate on the morphological state of rat brain tissue after the occlusion of left middle cerebral artery has been studied. It was found that 6- and 12-day treatment with 2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate at a dose of 100 mg/kg (intraperitoneal) led to regenerative processes in ischemic brain tissue. The latter treatment duration was most effective.
N A
NA
Bagdasarian
N G
NG
Khostikian
K B
KB
Alikhanian
V S
VS
Meliksetian
M G
MG
Bagdasarian
A G
AG
Stepanian
A M
AM
Kukhtarova
N R
NR
Mirzoian
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009336:Necrosis; D011725:Pyridines / Q000627:therapeutic use*; D051381:Rats
C000601079:2-methyl-6-ethyl-3-hydroxypyridine hemisuccinate; D011725:Pyridines