Influence of formulation technique on acrylate methacrylate copolymer modified paracetamol matrix tablets.
This work was designed to evaluate the influence of various methods such as dry granulation (DG), wet granulation (using the polymer in an ethanolic solution (WGO) or aqueous dispersion (WGA) and solid dispersion (SD) techniques, on properties of paracetamol matrix tablets prepared using varying concentrations of acrylate methacrylate copolymer. Tablet properties were investigated using official and unofficial standards. Drug dissolution profile assessed at pH 1.2 was studied spectrophotometrically at λ(max) of 245 nm. With the use of various kinetic models, the release mechanism of the drug was analyzed. The parameters, maximum amount of drug release (m(∞)) at time t(∞) were obtained, m(∞) was ≥ 91.36 %, while t(∞) was ≥ 4.5 h. The release rate constant (k) for DG tablets was 15.61 h(sup>-1(/sup>, while, WGO, WGA and SD tablets were 12.90, 11.03 and 10.75 h(-1) respectively. The matrix tablets, which exhibited marked retardation in drug release displayed a Higuchi square root of time model (R(2) > 0.98). The mechanism through which the drug was released was governed by Fickian diffusion release (n values < 0.5). The performance of the drug was affected by the formulation technique in the order of SD > WGO > WGA > DG.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Omonyemen Edoise
OE
Cash-Torunarigha
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Florence Egbomonjiade
FE
Eichie
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
Matthew Ikhuoria
MI
Arhewoh
D000082:Acetaminophen / Q000008:administration & dosage*; D000179:Acrylates / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D008689:Methacrylates / Q000008:administration & dosage*; D011108:Polymers / Q000008:administration & dosage*; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical
D000179:Acrylates; D008689:Methacrylates; D011108:Polymers; D013607:Tablets; D000082:Acetaminophen; C036658:acrylic acid