Increased Risk of Unfavorable Metabolic Outcome in Patients with Clinically Nonfunctioning Pituitary Adenomas.
The aim of this study was to investigate atherosclerotic risk markers in women with clinically nonfunctioning pituitary adenomas (CNFAs). Records of 47 women with CNFAs and 73 healthy women who were treated as outpatients between January 2010 and March 2014 were evaluated retrospectively. All study data were obtained from file records. Lipid parameters, mean platelet volume (MPV), total testosterone (TT), androstenedione (AS), and dehydroepiandrostenedione sulfate (DHEAS) were recorded. Insulin resistance (IR) was calculated with homeostatic model assessment-insulin resistance (HOMA-IR). Among the atherosclerotic risk markers, the HOMA-IR and AS levels were higher in patients with CNFAs than in healthy subjects (p=0.003, p=0.021, respectively). A positive correlation between AS and insulin/HOMA-IR levels was found among the metabolic parameters in the patients with CNFAs (p=0.001, r=0.550, p=0.004, r=0.498, respectively). The data showed that patients with CNFAs had high atherosclerotic risk markers such as insulin resistance and hyperandrogenemia. Insulin resistance may also cause hyperandrogenemia in patients with CNFAs.
Endocrinology and Metabolism Disease, Darıca Farabi State Hospital, Kocaeli, Turkey.
B A
BA
Doğan
Endocrinology and Metabolism Disease, Dicle University, Diyarbakır, Turkey.
M M
MM
Tuna
Endocrine and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes, National Institutes of Health, Bethesda, Maryland, USA.
A
A
Arduç
Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey.
M N
MN
Başaran
Endocrinology and Metabolism Disease, Hitit University, Çorum, Turkey.
K
K
Küçükler
Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey.
I
I
Dağdelen
Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey.
D
D
Berker
Endocrinology and Metabolism Disease, Ankara Numune Training and Research Hospital, Ankara, Turkey.
S
S
Güler
D000236:Adenoma / Q000097:blood / Q000150:complications*; D000328:Adult; D000735:Androstenedione / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000209:etiology*; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications*; D012306:Risk
D000735:Androstenedione