Epidemiology of coronary heart disease in HIV-infected versus uninfected individuals in developed countries.
The widespread use of combination antiretroviral therapy (cART) among people living with HIV in developed countries has lead to significantly improved life expectancy. However, extensive use of the effective cART coincides with increasing reports of coronary heart disease (CHD) among people living with HIV, and CHD has become a major cause of death. CHD results from a complex and multifactorial atherosclerotic process involving the over-representation of traditional cardiovascular risk factors, particularly smoking, uncontrolled viral replication, chronic inflammation, immune activation, and exposure to antiretroviral drugs. Consequently careful selection of antiretroviral drugs, cardiovascular risk reduction, and lifestyle modifications are needed. In individuals living with HIV, cardiovascular risk assessment is becoming an important element of care.
Service de cardiologie, hôpital Saint-Antoine, AP-HP, 75012 Paris, France.
Sylvie
S
Lang
Service de cardiologie, hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Sorbonne universités, UPMC université Paris 06, 75012 Paris, France; Inserm UMR_S 938, 75012 Paris, France.
Franck
F
Boccara
Inserm, UMR_S 1136, institut Pierre-Louis d'épidémiologie et de santé publique, 75013 Paris, France; Sorbonne universités, UPMC université Paris 06, UMR_S 1146, institut Pierre-Louis d'épidémiologie et de santé publique, 75013 Paris, France.
Murielle
M
Mary-Krause
Service de cardiologie, hôpital Saint-Antoine, AP-HP, 75012 Paris, France; Sorbonne universités, UPMC université Paris 06, 75012 Paris, France. Electronic address: ariel.cohen@sat.aphp.fr.
Ariel
A
Cohen
D044966:Anti-Retroviral Agents / Q000009:adverse effects*; D003327:Coronary Disease / Q000139:chemically induced* / Q000453:epidemiology*; D019049:Developed Countries; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D012307:Risk Factors
D044966:Anti-Retroviral Agents
Antiretroviral therapy; Coronary heart disease; Human immunodeficiency virus; Maladie coronaire; Traitements antirétroviraux; Virus de l’immunodéficience acquise