Strategically designed biomodel: engineering C3-C4 cleavage of D-fructose.
Amongst a library of aldolase inspired, rationally designed compounds, the acridine derivative carrying a (S)-Tyr-Gly-(S)-Lys tripeptide selectively effected C3-C4 scissoring of D-fructose and produced D-glyceraldehyde and dihydroxyacetone.
UGC Sponsored Centre for Advanced Studies, Department of Chemistry, Guru Nanak Dev University, Amritsar 143005, India. palwinder_singh_2000@yahoo.com.
Palwinder
P
Singh
Arun
A
Kumar
Sukhmeet
S
Kaur
Amrinder
A
Singh
D000166:Acridines / Q000737:chemistry; D004098:Dihydroxyacetone / Q000737:chemistry; D015195:Drug Design; D005632:Fructose / Q000737:chemistry*; D005985:Glyceraldehyde / Q000737:chemistry
D000166:Acridines; D005632:Fructose; D005985:Glyceraldehyde; D004098:Dihydroxyacetone