A case-control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD).
Neurological diseases are common in inflammatory bowel disease (IBD) patients, but their exact prevalence is unknown. Method We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD) and 70 with ulcerative colitis (UC)] and 50 controls (gastritis and dyspepsia) over 3 years. Results Our standard neurological evaluation (that included electrodiagnostic testing) revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045), 7.1 times more likely to develop any type of neuromuscular condition (p = 0.001) and 5.1 times more likely to develop autonomic complaints (p = 0.027). UC patients were 5 times more likely to develop large-fiber neuropathy (p = 0.027) and 3.1 times more likely to develop any type of neuromuscular condition (p = 0.015). Conclusion In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases than patients with gastritis and dyspepsia.
Departamento de Medicina Clínica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Francisco de Assis Aquino
Fde A
Gondim
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Gisele Ramos de
GR
Oliveira
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Benedito Cadorno V
BC
Teles
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Marcellus H L P
MH
Souza
Departamento de Medicina Clínica, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Lucia L B C
LL
Braga
Psychiatry Research Institute, University of Arkansas, Little Rock, AR, USA.
Erick L
EL
Messias
D000328:Adult; D000704:Analysis of Variance; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D004415:Dyspepsia / Q000150:complications; D005260:Female; D005756:Gastritis / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric