New insights into the molecular profile of lung adenocarcinoma and implications for therapy.
Lung cancer is a molecularly heterogeneous disease. The advent of next-generation sequencing techniques has significantly advanced our understanding of the complex molecular underpinnings of lung cancer. Furthermore, the development of targeted therapies has significantly altered the landscape of lung cancer therapy over the past decade. There is hence an increasing interest in developing a classification system that guides clinical management and also incorporates relevant genomic information. Here, we highlight the molecular features of lung adenocarcinoma as highlighted by several independent groups, and more recently The Cancer Genome Atlas and discuss their potential clinical significance.
1 Division of Medical Oncology, Washington University School of Medicine in St. Louis, 660 S. Euclid, Box 8056, St. Louis, MO 63021, USA.
Bharath
B
Ganesh
Siddhartha
S
Devarakonda
Ramaswamy
R
Govindan
D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D000077192:Adenocarcinoma of Lung; D015894:Genome, Human; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D058990:Molecular Targeted Therapy
NSCLC; adenocarcinoma; genome sequencing; lung cancer; molecular classification