Suicidal behavior in the context of disrupted rhythmicity in bipolar disorder--data from an association study of suicide attempts with clock genes.
Suicidal behavior exhibits both circadian and annual rhythms. We were seeking an association between selected candidate clock genes and suicidal behavior in bipolar patients. The study included 441 bipolar patients and 422 controls and we genotyped 41 SNPs of the CLOCK, ARNTL, TIMELESS, PER3 genes. The main positive findings built up associations between selected polymorphisms and.
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland. Electronic address: joanna.pawlak@gmail.com.
Joanna
J
Pawlak
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland.
Monika
M
Dmitrzak-Weglarz
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland; Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Malgorzata
M
Maciukiewicz
Department of Individual Differences, Institute of Psychology, University of Bydgoszcz, Poland.
Monika
M
Wilkosc
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland.
Anna
A
Leszczynska-Rodziewicz
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland.
Dorota
D
Zaremba
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poland.
Pawel
P
Kapelski
Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poland.
Joanna
J
Hauser
D056930:ARNTL Transcription Factors / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D056926:CLOCK Proteins / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D030541:Databases, Genetic; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology; D055815:Young Adult
D056930:ARNTL Transcription Factors; D056926:CLOCK Proteins
Circadian rhythm; Clock genes; Suicide