Quantitative EEG and medial temporal lobe atrophy in Alzheimer's dementia: Preliminary study.
BACKGROUND
The electroencephalogram (EEG) abnormalities in Alzheimer's disease (AD) have been widely reported, and medial temporal lobe atrophy (MTLA) is one of the hallmarks in early stage of AD. We aimed to assess the relationship between EEG abnormalities and MTLA and its clinical validity.


METHODS
A total of 18 patients with AD were recruited (the mean age: 77.83 years). Baseline EEGs were analyzed with quantitative spectral analysis. MTLA was assessed by a T1-axial visual rating scale (VRS).


RESULTS
In relative power spectrum analysis according to the right MTLA severity, the power of theta waves in C4, T4, F4, F8, and T5 increased significantly and the power of beta waves in T6, C4, T4, F8, T5, P3, T3, and F7 decreased significantly in severe atrophy group. In relative power spectrum analysis according to the left MTLA severity, the power of theta waves in T3 increased significantly and that of beta waves in P4, T6, C4, F4, F8, T5, P3, C3, T3, F3, and F7 decreased significantly in severe atrophy group.


CONCLUSIONS
The severe MTLA group, regardless of laterality, showed more severe quantitative EEG alterations. These results suggest that quantitative EEG abnormalities are correlated with the MTLA, which may play an important role in AD process.
Department of Neurology, Seoul Medical Center, Seoul, Korea.
Soo-Ji
SJ
Lee
Department of Neurology, Seoul Medical Center, Seoul, Korea.
Min-Ho
MH
Park
Department of Neurology, Seoul Medical Center, Seoul, Korea.
Sang-Soon
SS
Park
Department of Neurology, Seoul Medical Center, Seoul, Korea.
Jin-Young
JY
Ahn
Department of Neurology, Seoul Medical Center, Seoul, Korea.
Jae-Hyeok
JH
Heo
Alzheimer's disease; medial temporal lobe atrophy; quantitative EEG