Enantioselective ruthenium-catalyzed carbonyl allylation via alkyne-alcohol C-C bond-forming transfer hydrogenation: allene hydrometalation vs oxidative coupling.
Chiral ruthenium(II) complexes modified by Josiphos ligands catalyze the reaction of alkynes with primary alcohols to form homoallylic alcohols with excellent control of regio-, diastereo-, and enantioselectivity. These processes represent the first examples of enantioselective carbonyl allylation using alkynes as allylmetal equivalents.
Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Tao
T
Liang
Khoa D
KD
Nguyen
Wandi
W
Zhang
Michael J
MJ
Krische
D000438:Alcohols / Q000737:chemistry*; D000466:Alkadienes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D000466:Alkadienes; D000480:Alkynes; D000498:Allyl Compounds; C025947:propadiene; D012428:Ruthenium