Biodegradation-tunable mesoporous silica nanorods for controlled drug delivery.
Mesoporous silica in the forms of micro- or nanoparticles showed great potentials in the field of controlled drug delivery. However, for precision control of drug release from mesoporous silica-based delivery systems, it is critical to control the rate of biodegradation. Thus, in this study, we demonstrate a simple and robust method to fabricate "biodegradation-tunable" mesoporous silica nanorods based on capillary wetting of anodic aluminum oxide (AAO) template with an aqueous alkoxide precursor solution. The porosity and nanostructure of silica nanorods were conveniently controlled by adjusting the water/alkoxide molar ratio of precursor solutions, heat-treatment temperature, and Na addition. The porosity and biodegradation kinetics of the fabricated mesoporous nanorods were analyzed using N2 adsorption/desorption isotherm, TGA, DTA, and XRD. Finally, the performance of the mesoporous silica nanorods as drug delivery carrier was demonstrated with initial burst and subsequent "zero-order" release of anti-cancer drug, doxorubicin.
School of Advanced Materials & System Engineering, Kumoh National Institute of Technology, 1 Yangho-dong, Gumi, Gyeongbuk 730-701, Republic of Korea.
Sung Bum
SB
Park
School of Advanced Materials & System Engineering, Kumoh National Institute of Technology, 1 Yangho-dong, Gumi, Gyeongbuk 730-701, Republic of Korea.
Young-Ho
YH
Joo
School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Hyunryung
H
Kim
School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea. Electronic address: whryu@yonsei.ac.kr.
WonHyoung
W
Ryu
School of Advanced Materials & System Engineering, Kumoh National Institute of Technology, 1 Yangho-dong, Gumi, Gyeongbuk 730-701, Republic of Korea. Electronic address: yipark@kumoh.ac.kr.
Yong-il
YI
Park
D000327:Adsorption; D000537:Aluminum Oxide / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D004566:Electrodes; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D014867:Water; D012822:Silicon Dioxide; D004317:Doxorubicin; D012964:Sodium; D000537:Aluminum Oxide; D009584:Nitrogen
Anodic aluminum oxide; Biodegradation; Drug delivery; Mesoporous; Silica nanorods