Radio frequency responsive nano-biomaterials for cancer therapy.
Radiofrequency (RF)-assisted cancer therapy is well-known in the medical field as it is non-hazardous and can penetrate tissues, enabling a deeply rooted cancer treatment. However, the current treatment regimen is non-specific and invasive, making it difficult for patients to undergo the RF ablation procedure. Recently, there has been tremendous attention given on replacing RF probes (through which the RF current passes into the tumors) with metallic nanoparticles (NPs) such as gold and iron oxide. These metallic NPs can be combined with stimuli responsive polymers to have a simultaneous drug delivery to tumors and better thermal ablation. This review will give a brief overview on the various nanobiomaterials based on metals and polymers and their composites in RF-assisted cancer therapy. Special attention has been given on RF responsive composite nanomaterials. Besides these, the importance of RF-assisted drug delivery using the nanobiomaterials for cancer therapy, as well as the advantages and future perspectives of these materials are discussed in detail.
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
N Sanoj
NS
Rejinold
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India.
R
R
Jayakumar
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. Electronic address: dohnanyi@kaist.ac.kr.
Yeu-Chun
YC
Kim
D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000737:chemistry; D017209:Apoptosis; D017115:Catheter Ablation / Q000379:methods*; D005290:Ferric Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage* / Q000737:chemistry; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D058726:Nanoconjugates / Q000008:administration & dosage* / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D045663:Quantum Dots / Q000737:chemistry
D000911:Antibodies, Monoclonal; D005290:Ferric Compounds; D018796:Immunoconjugates; D058726:Nanoconjugates; D037742:Nanotubes, Carbon; C000499:ferric oxide; D006046:Gold
Applications; Future directions; Limitations; RF responsive nano-biomaterials