[Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma].
OBJECTIVE
To study the expression of DNA-dependent protein kinase (DNA-PK) in human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa (NLM), and to analysize the relationship between the expression and the clinicopathologic parameters of LSCC.


METHODS
Immunohistochemical technique (Envision) was used to detect the expression of DNA-PK in 64 cases of LSCC and 15 cases of NLM. To investigate an investigation was conducted on the relationship between the expression and clinico-pathological features of LSCC.


RESULTS
DNA-PK was lowly expressed in NLM and highly expressed in LSCC,the positive rate of DNA-PK expression was 26.67% (4/15), 78.13% (50/64), respectively, and there was significant different difference between the two groups (P < 0.05). Its expression was correlated with the level of histodifferentiation (P < 0.05), but not with TNM stages and neck lymph node metastasis (P > 0.05).


CONCLUSIONS
DNA-PK may be involved in disease development of LSCC.
Jiansong
J
Sun
Xiuhai
X
Yang
Hongpei
H
Ji
Rui
R
Zhao
Yubing
Y
Dai
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D051747:DNA-Activated Protein Kinase / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D007820:Laryngeal Mucosa / Q000201:enzymology; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000473:pathology; D007830:Larynx / Q000201:enzymology*; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D000077195:Squamous Cell Carcinoma of Head and Neck
D051747:DNA-Activated Protein Kinase