Standardizing Predicted Body Weight Equations for Mechanical Ventilation Tidal Volume Settings.
BACKGROUND
Recent recommendations for lung protective mechanical ventilation include a tidal volume target of 6 mL/kg predicted body weight (PBW). Different PBW equations might introduce important differences in tidal volumes delivered to research subjects and patients.


METHODS
PBW equations use height, age, and sex as input variables. We compared National Institutes of Health (NIH) ARDS Network (ARDSNet), actuarial table (ACTUARIAL), and Stewart (STEWART) PBW equations used in clinical trials, across physiologic ranges for age and height. We used three-dimensional and two-dimensional surface analysis to compare these PBW equations. We then used age and height from actual clinical trial subjects to quantify PBW equation differences.


RESULTS
Significant potential differences existed between these PBW predictions. The ACTUARIAL and ARDSNet surfaces for women were the only surfaces that intersected and produced both positive and negative differences. Mathematical differences between PBW equations at limits of height and age exceeded 30% in women and 24% in men for ACTUARIAL vs ARDSNet and about 25% for women and 15% for men for STEWART vs ARDSNet. The largest mathematical differences were present in older, shorter subjects, especially women. Actual differences for clinical trial subjects were as high as 15% for men and 24% for women.


CONCLUSIONS
Significant differences between PBW equations for both men and women could be important sources of interstudy variation. Studies should adopt a standard PBW equation. We recommend using the NIH National Heart, Lung, and Blood Institute ARDS Network PBW equation because it is associated with the clinical trial that identified 6 mL/kg PBW as an appropriate target.
Pulmonary and Critical Care Division, Department of Medicine, Intermountain Medical Center, Salt Lake City, UT. Electronic address: Olinto.linares@imail.org.
Olinto
O
Linares-Perdomo
LCF Research, New Mexico Health Information Collaborative, Albuquerque, NM; LCF Research, New Mexico Health Information Collaborative, Albuquerque, NM.
Thomas D
TD
East
Pulmonary and Critical Care Medicine (Dr Brower), Johns Hopkins University School of Medicine, Baltimore, MD.
Roy
R
Brower
Pulmonary and Critical Care Division, Department of Medicine, Intermountain Medical Center, Salt Lake City, UT; University of Utah School of Medicine, Salt Lake City, UT.
Alan H
AH
Morris
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001827:Body Height; D001835:Body Weight; D005260:Female; D006801:Humans; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D011237:Predictive Value of Tests; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000503:physiopathology / Q000628:therapy*; D012737:Sex Factors; D013990:Tidal Volume; D014481:United States; D055815:Young Adult