Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Kyriaki
K
Michailidou
Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jonathan
J
Beesley
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA.
Sara
S
Lindstrom
Division of Molecular Carcinogenesis, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Sander
S
Canisius
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joe
J
Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Michael J
MJ
Lush
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mel J
MJ
Maranian
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Manjeet K
MK
Bolla
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Qin
Q
Wang
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mitul
M
Shah
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Barbara J
BJ
Perkins
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kamila
K
Czene
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael
M
Eriksson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hatef
H
Darabi
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Judith S
JS
Brand
1] Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [3] Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Stig E
SE
Bojesen
1] Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [3] Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Børge G
BG
Nordestgaard
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Henrik
H
Flyger
1] Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark. [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark.
Sune F
SF
Nielsen
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Nazneen
N
Rahman
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Clare
C
Turnbull
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Olivia
O
Fletcher
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Julian
J
Peto
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Lorna
L
Gibson
Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Isabel
I
dos-Santos-Silva
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny
J
Chang-Claude
1] Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany. [2] Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Dieter
D
Flesch-Janys
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja
A
Rudolph
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ursula
U
Eilber
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sabine
S
Behrens
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli
H
Nevanlinna
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Taru A
TA
Muranen
Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland.
Kristiina
K
Aittomäki
Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Carl
C
Blomqvist
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Sofia
S
Khan
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Kirsimari
K
Aaltonen
1] Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA. [2] Department of Health Studies, University of Chicago, Chicago, Illinois, USA. [3] Department of Medicine, University of Chicago, Chicago, Illinois, USA. [4] Department of Human Genetics, University of Chicago, Chicago, Illinois, USA. [5] Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA.
Habibul
H
Ahsan
1] Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA. [2] Department of Health Studies, University of Chicago, Chicago, Illinois, USA.
Muhammad G
MG
Kibriya
1] Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
Alice S
AS
Whittemore
1] Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. [2] Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA. [3] Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
Esther M
EM
John
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Kathleen E
KE
Malone
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Marilie D
MD
Gammon
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York, USA.
Regina M
RM
Santella
Cancer Registry of Norway, Oslo, Norway.
Giske
G
Ursin
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Victoria, Australia.
Enes
E
Makalic
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, Melbourne, Victoria, Australia.
Daniel F
DF
Schmidt
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Graham
G
Casey
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA.
David J
DJ
Hunter
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
Susan M
SM
Gapstur
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
Mia M
MM
Gaudet
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
W Ryan
WR
Diver
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Christopher A
CA
Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Fredrick
F
Schumacher
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Brian E
BE
Henderson
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
Loic
L
Le Marchand
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Christine D
CD
Berg
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Stephen J
SJ
Chanock
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Jonine
J
Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Robert N
RN
Hoover
1] Vesalius Research Center, VIB, Leuven, Belgium. [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Diether
D
Lambrechts
Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium.
Patrick
P
Neven
Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium.
Hans
H
Wildiers
Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, Belgium.
Erik
E
van Limbergen
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Marjanka K
MK
Schmidt
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Annegien
A
Broeks
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Senno
S
Verhoef
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Sten
S
Cornelissen
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Fergus J
FJ
Couch
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Janet E
JE
Olson
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Emily
E
Hallberg
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Celine
C
Vachon
Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, the Netherlands.
Quinten
Q
Waisfisz
Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, the Netherlands.
Hanne
H
Meijers-Heijboer
Department of Clinical Genetics, Section Oncogenetics, VU University Medical Center, Amsterdam, the Netherlands.
Muriel A
MA
Adank
Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Rob B
RB
van der Luijt
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jingmei
J
Li
Human Genetics Division, Genome Institute of Singapore, Singapore.
Jianjun
J
Liu
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Keith
K
Humphreys
1] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. [3] Cancer Research Institute, Seoul National University, Seoul, Korea.
Daehee
D
Kang
1] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. [2] Cancer Research Institute, Seoul National University, Seoul, Korea.
Ji-Yeob
JY
Choi
1] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea. [3] Cancer Research Institute, Seoul National University, Seoul, Korea.
Sue K
SK
Park
Seoul National University College of Medicine, Seoul, Korea.
Keun-Young
KY
Yoo
Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan.
Keitaro
K
Matsuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Hidemi
H
Ito
Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
Hiroji
H
Iwata
Epidemiology Center for Disease Control and Prevention, Mie University Hospital, Tsu, Japan.
Kazuo
K
Tajima
1] INSERM), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France. [2] University Paris-Sud, UMRS 1018, Villejuif, France.
Pascal
P
Guénel
1] INSERM), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France. [2] University Paris-Sud, UMRS 1018, Villejuif, France.
Thérèse
T
Truong
Université Paris Sorbonne Cité, UMRS 775, INSERM, Paris, France.
Claire
C
Mulot
1] INSERM), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France. [2] University Paris-Sud, UMRS 1018, Villejuif, France.
Marie
M
Sanchez
1] Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany. [2] Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara
B
Burwinkel
1] Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany. [2] National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Frederik
F
Marme
1] Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany. [2] Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Harald
H
Surowy
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Christof
C
Sohn
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Anna H
AH
Wu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Chiu-chen
CC
Tseng
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
David
D
Van Den Berg
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Daniel O
DO
Stram
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Anna
A
González-Neira
1] Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [2] Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Javier
J
Benitez
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
M Pilar
MP
Zamora
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
Jose Ignacio Arias
JI
Perez
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Xiao-Ou
XO
Shu
Shanghai Center for Disease Control and Prevention, Changning, China.
Wei
W
Lu
Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Yu-Tang
YT
Gao
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Hui
H
Cai
1] Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK. [2] Department of Oncology, University of Sheffield, Sheffield, UK.
Angela
A
Cox
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Simon S
SS
Cross
1] Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK. [2] Department of Oncology, University of Sheffield, Sheffield, UK.
Malcolm W R
MW
Reed
1] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Irene L
IL
Andrulis
1] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. [2] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Julia A
JA
Knight
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Gord
G
Glendon
1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
Anna Marie
AM
Mulligan
Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, London, UK.
Elinor J
EJ
Sawyer
1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. [2] Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Ian
I
Tomlinson
Department of Surgery, School of Medicine, National University of Ireland, Galway, Ireland.
Michael J
MJ
Kerin
Department of Surgery, School of Medicine, National University of Ireland, Galway, Ireland.
Nicola
N
Miller
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Annika
A
Lindblom
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Sara
S
Margolin
1] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. [2] Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
Soo Hwang
SH
Teo
Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
Cheng Har
CH
Yip
Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
Nur Aishah Mohd
NA
Taib
Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre (UMMC), Kuala Lumpur, Malaysia.
Gie-Hooi
GH
Tan
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Maartje J
MJ
Hooning
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Antoinette
A
Hollestelle
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
John W M
JW
Martens
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
J Margriet
JM
Collée
1] Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. [2] International Epidemiology Institute, Rockville, Maryland, USA.
William
W
Blot
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Lisa B
LB
Signorello
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Qiuyin
Q
Cai
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
John L
JL
Hopper
Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Melissa C
MC
Southey
Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Helen
H
Tsimiklis
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Carmel
C
Apicella
1] Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. [2] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. [3] School of Public Health, China Medical University, Taichung, Taiwan.
Chen-Yang
CY
Shen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chia-Ni
CN
Hsiung
1] Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. [2] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Pei-Ei
PE
Wu
1] Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan. [2] Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.
Ming-Feng
MF
Hou
1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway. [2] Institute of Clinical Medicine, University of Oslo, Oslo, Norway. [3] Department of Clinical Molecular Biology (EpiGen), University of Oslo, Oslo, Norway.
Vessela N
VN
Kristensen
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Silje
S
Nord
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Grethe I Grenaker
GI
Alnaes
1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. [2] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Graham G
GG
Giles
1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia. [2] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Roger L
RL
Milne
Department of Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia.
Catriona
C
McLean
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Federico
F
Canzian
1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens, Greece.
Dimitrios
D
Trichopoulos
1] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands. [2] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Petra
P
Peeters
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway.
Eiliv
E
Lund
Department of Surgical and Perioperative Sciences, Umea University, Umea, Sweden.
Malin
M
Sund
School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK.
Kay-Tee
KT
Khaw
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Marc J
MJ
Gunter
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence, Italy.
Domenico
D
Palli
Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Lotte Maxild
LM
Mortensen
1] INSERM Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] Université Paris-Sud, Villejuif, France.
Laure
L
Dossus
Department of Epidemiology, Consejería de Sanidad y Política Social, CIBER de Epidemiología y Salud Pública, Murcia, Spain.
Jose-Maria
JM
Huerta
Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Alfons
A
Meindl
1] Center for Hereditary Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany. [2] Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany.
Rita K
RK
Schmutzler
Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Christian
C
Sutter
1] Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany. [2] Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rongxi
R
Yang
1] Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK. [2] Institute of Population Health, University of Manchester, Manchester, UK.
Kenneth
K
Muir
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.
Artitaya
A
Lophatananon
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.
Sarah
S
Stewart-Brown
Ministry of Public Health, Nonthaburi, Thailand.
Pornthep
P
Siriwanarangsan
1] Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. [2] Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Mikael
M
Hartman
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Hui
H
Miao
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Kee Seng
KS
Chia
Division of General Surgery, National University Health System, Singapore.
Ching Wan
CW
Chan
1] Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center of the Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany. [2] Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Peter A
PA
Fasching
Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center of the Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany.
Alexander
A
Hein
Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center of the Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany.
Matthias W
MW
Beckmann
Department of Gynecology and Obstetrics, University Breast Center Franconia, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center of the Erlangen-Nuremberg Metropolitan Region, Erlangen, Germany.
Lothar
L
Haeberle
1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium (DKTK), Heidelberg, Germany.
Hermann
H
Brenner
1] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] German Cancer Consortium (DKTK), Heidelberg, Germany.
Aida Karina
AK
Dieffenbach
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Volker
V
Arndt
Saarland Cancer Registry, Saarbrücken, Germany.
Christa
C
Stegmaier
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Alan
A
Ashworth
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Nick
N
Orr
Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
Minouk J
MJ
Schoemaker
1] Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. [2] Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Anthony J
AJ
Swerdlow
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Louise
L
Brinton
1] Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. [2] Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Montserrat
M
Garcia-Closas
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Wei
W
Zheng
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Sandra L
SL
Halverson
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Martha
M
Shrubsole
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jirong
J
Long
1] Department of Medicine, McGill University, Montreal, Quebec, Canada. [2] Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
Mark S
MS
Goldberg
1] Département de Santé Environnementale et Santé au Travail, Ecole de Santé Publique, Université de Montréal, Montreal, Quebec, Canada. [2] Département de Médecine Sociale et Préventive, Ecole de Santé Publique, Université de Montréal, Montreal, Quebec, Canada.
France
F
Labrèche
1] Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada. [2] Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.
Martine
M
Dumont
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland.
Robert
R
Winqvist
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland.
Katri
K
Pylkäs
Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Arja
A
Jukkola-Vuorinen
Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mervi
M
Grip
1] German Cancer Consortium (DKTK), Heidelberg, Germany. [2] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany. [3] University of Tübingen, Tübingen, Germany. [4] German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hiltrud
H
Brauch
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute
U
Hamann
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
Thomas
T
Brüning
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
Paolo
P
Radice
Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy.
Paolo
P
Peterlongo
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
Siranoush
S
Manoukian
1] Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy. [2] Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Loris
L
Bernard
Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Natalia V
NV
Bogdanova
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Thilo
T
Dörk
1] School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. [2] Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland. [3] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Arto
A
Mannermaa
1] Cancer Center, Kuopio University Hospital, Kuopio, Finland. [2] Central Finland Hospital District, Jyväskylä Central Hospital, Jyväskylä, Finland.
Vesa
V
Kataja
1] School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. [2] Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland. [3] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Veli-Matti
VM
Kosma
1] School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland. [2] Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland. [3] Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Jaana M
JM
Hartikainen
1] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. [2] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Peter
P
Devilee
Department of Surgical Oncology, Leiden University Medical Center, Leiden, the Netherlands.
Robert A E M
RA
Tollenaar
Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Caroline
C
Seynaeve
Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Christi J
CJ
Van Asperen
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna
K
Jaworska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Tomasz
T
Huzarski
National Cancer Institute of Thailand, Bangkok, Thailand.
Suleeporn
S
Sangrajrang
International Agency for Research on Cancer, Lyon, France.
Valerie
V
Gaborieau
International Agency for Research on Cancer, Lyon, France.
Paul
P
Brennan
International Agency for Research on Cancer, Lyon, France.
James
J
McKay
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Susan
S
Slager
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA.
Amanda E
AE
Toland
Roswell Park Cancer Institute, Buffalo, New York, USA.
Christine B
CB
Ambrosone
Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
Drakoulis
D
Yannoukakos
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Maria
M
Kabisch
1] Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Institute of Human Genetics, Pontificia Universidad Javeriana, Bogotá, Colombia.
Diana
D
Torres
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
Susan L
SL
Neuhausen
Department of Epidemiology, University of California-Irvine, Irvine, California, USA.
Hoda
H
Anton-Culver
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Craig
C
Luccarini
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Caroline
C
Baynes
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Shahana
S
Ahmed
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Catherine S
CS
Healey
McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.
Daniel C
DC
Tessier
McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.
Daniel
D
Vincent
McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.
Francois
F
Bacot
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Guillermo
G
Pita
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
M Rosario
MR
Alonso
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Nuria
N
Álvarez
Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniel
D
Herrero
1] Centre Hospitalier Universitaire de Québec Research Center, Quebec City, Quebec, Canada. [2] Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.
Jacques
J
Simard
1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Paul P D P
PP
Pharoah
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts, USA.
Peter
P
Kraft
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Alison M
AM
Dunning
Department of Genetics, QIMR (Queensland Institute for Medical Research) Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Georgia
G
Chenevix-Trench
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Per
P
Hall
1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Douglas F
DF
Easton
D005260:Female; D006801:Humans; D001943:Breast Neoplasms / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D046228:Microarray Analysis; D020641:Polymorphism, Single Nucleotide