Fibulins and their role in cardiovascular biology and disease.
Fibulins are a group of extracellular matrix proteins of which many are present in high amounts in the cardiovascular system. They share common biochemical properties and are often found in relation to basement membranes or elastic fibers. Observations in humans with specific mutations in fibulin genes, together with results from genetically engineered mice and data from human cardiovascular tissue suggest that the fibulin family of proteins play important functional roles in the cardiovascular system. Moreover, fibulin-1 circulates in high concentrations in plasma and may function as a cardiovascular disease marker.
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Claudia
C
Cangemi
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Maria Lyck
ML
Hansen
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
William Scott
WS
Argraves
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark. Electronic address: lars.melholt.rasmussen@rsyd.dk.
Lars Melholt
LM
Rasmussen
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006487:Hemostasis; D006801:Humans; D018345:Mice, Knockout
D015415:Biomarkers; D002135:Calcium-Binding Proteins; C403672:EFEMP2 protein, human; D016326:Extracellular Matrix Proteins; C060820:fibulin; C084612:fibulin 2
Arteries; Biomarkers; Cardiovascular diseases; Extracellular matrix; Glycoproteins