Cobalt-catalyzed C-H arylations with weakly-coordinating amides and tetrazoles: expedient route to angiotensin-II-receptor blockers.
Cobalt-catalyzed C-H arylations enabled the synthesis of biaryl tetrazoles, which are key structural motifs in antihypertensive angiotensin-II-receptor blockers. Thus, weakly-coordinating benzamides were employed for step-economical C-H arylations with ample scope. Further, a low-valent NHC complex enabled first cobalt-catalyzed C-H functionalization by tetrazole assistance.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
Jie
J
Li
Lutz
L
Ackermann
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D057911:Angiotensin Receptor Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D001549:Benzamides / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D057911:Angiotensin Receptor Antagonists; D001549:Benzamides; D013777:Tetrazoles; C045574:1H-tetrazole; D003035:Cobalt; C037689:benzamide
CH activation; amides; arylation; cobalt; tetrazoles