Formulation and optimization of efavirenz nanosuspensions using the precipitation-ultrasonication technique for solubility enhancement.
Efavirenz is a non-nucleoside reverse transcriptase inhibitor, and is classiﬁed as BCS Class II API. Its erratic oral absorption and poor bioavailability make it a potential candidate for being formulated as a nanosuspension. The objective of this study was to formulate efavirenz nanosuspensions employing the antisolvent precipitation-ultrasonication method, and to enhance its solubility by reducing particle size to the nanometer range. The effects of different process parameters were studied and optimized with respect to particle size and poly dispersity index (PDI). The optimized formulation was also subjected to lyophilization, to further increase the solubility and stability, and the technology is potentially suited to a range of poorly water-soluble compounds.
a Department of Quality Assurance , ISF College of Pharmacy , Moga , Punjab , India.
Sakshi
S
Taneja
b Department of Pharmaceutics , Ravishankar College of Pharmacy , Bhopal , Madhya Pradesh , India.
Satish
S
Shilpi
b Department of Pharmaceutics , Ravishankar College of Pharmacy , Bhopal , Madhya Pradesh , India.
Kapil
K
Khatri
D000480:Alkynes; D048588:Benzoxazines / Q000737:chemistry* / Q000493:pharmacokinetics*; D003521:Cyclopropanes; D053758:Nanoparticles / Q000737:chemistry*; D012995:Solubility; D013535:Suspensions; D000069453:Ultrasonic Waves
D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D013535:Suspensions; C098320:efavirenz
bioavailability; drug delivery; nanotechnology; solubility enhancement; solvent-antisolvent