Role of MicroRNAs in Prostate Cancer Pathogenesis.
Prostate cancer (PCa) remains the most commonly diagnosed malignant tumor in men, and is the second highest cause of cancer mortality after lung tumors in the United States. Accumulating research indicates that microRNAs (miRNAs) are increasingly being implicated in PCa. miRNAs are conserved small noncoding RNAs that control gene expression posttranscriptionally. Recent profiling research suggests that miRNAs are aberrantly expressed in PCa, and these have been implicated in the regulation of apoptosis, cell cycle, epithelial to mesenchymal transition, PCa stem cells, and androgen receptor pathway. All of these might provide the basis for new approaches for PCa. Here, we review current findings regarding miRNA research in PCa to provide a strong basis for future study aimed at promising contributions of miRNA in PCa.
Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
You-Lin
YL
Wang
Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. Electronic address: wushuai_78@163.com.
Shuai
S
Wu
Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Bo
B
Jiang
Department of Obstetrics and Gynecology, Affiliate Hospital of Qingdao University, Qingdao, China.
Fu-Fen
FF
Yin
Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
Shuai-Shuai
SS
Zheng
Department of Urology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. Electronic address: housichuan@sina.cn.
Si-Chuan
SC
Hou
D000728:Androgens / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D001859:Bone Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D034622:RNA Interference; D015398:Signal Transduction
D000728:Androgens; D035683:MicroRNAs
Androgen; Apoptosis; Cancer stem cells; Epithelial to mesenchymal transition; Metastasis