Prevalence of penicillin-non-susceptible Streptococcus pneumoniae in children in day-care centres subjected to an intervention to prevent dispersion.
BACKGROUND
The aim of this study was to evaluate the day-care interventions implemented in southern Sweden to restrict the dispersion of penicillin-non-susceptible pneumococci with a minimum inhibitory concentration of penicillin G of at least 0.5 mg/l (PNSP0.5).


METHODS
A retrospective epidemiological study was performed and data from 109 day-care centre interventions from 2000 to 2010 were analysed, including screening results from 7157 individuals.


RESULTS
It was found that 42% of the children were carriers of pneumococci and 5% of the screened children were PNSP0.5 carriers. Very few personnel were PNSP0.5 carriers and they were carriers for only a short time. Significantly more contact cases with the same serogroup as the index case were found in the first screening and in the same department as the index case, but a substantial number of contact cases were found in adjacent departments.


CONCLUSIONS
Screening of personnel is not worth the effort. Based on our results, procedures to restrict dispersion of PNSP0.5 in day-care centres could be improved. To find the majority of contact cases with PNSP0.5 an early screening including adjacent departments seems to be the best approach.
From the Infectious Disease Unit, Department of Clinical Sciences, Lund University , Malmö , Sweden.
Jonas
J
Ahl
Eva
E
Melander
Inga
I
Odenholt
Lisa
L
Tvetman
Tora
T
Thörnblad
Kristian
K
Riesbeck
Håkan
H
Ringberg
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002353:Carrier State; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology; D010400:Penicillin G / Q000494:pharmacology; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D015995:Prevalence; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000302:isolation & purification; D013548:Sweden / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D010400:Penicillin G
Communicable disease control intervention; Streptococcus pneumoniae; day-care centre; penicillin non-susceptible pneumococci; pneumococcal carriage