Automated radiosynthesis of [(18)F]ciprofloxacin.
We transferred the previously published manual synthesis of [(18)F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab(TM) FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [(18)F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% (n=23) with a specific activity at EOS of 1.4±0.5GBq/µmol in a synthesis time of 160min.
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
Johann
J
Stanek
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
Severin
S
Mairinger
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
Thomas
T
Wanek
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria.
Claudia
C
Kuntner
Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria.
Markus
M
Müller
Health and Environment Department, AIT Austrian Institute of Technology GmbH, A-2444 Seibersdorf, Austria; Department of Clinical Pharmacology, Medical University of Vienna, Währiger-Gürtel 18-20, A-1090 Vienna, Austria. Electronic address: oliver.langer@ait.ac.at.
Oliver
O
Langer
D002939:Ciprofloxacin / Q000737:chemistry* / Q000302:isolation & purification; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005462:Fluorine Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification; D012371:Robotics / Q000295:instrumentation* / Q000379:methods
D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D002939:Ciprofloxacin
(18)F/(19)F exchange; Automated synthesis; Radiochemical yield; Reactor type; TRACERlab(TM) FX(FDG); [(18)F]ciprofloxacin