[Subarachnoid meloxicam does not inhibit the mechanical hypernociception on carrageenan test in rats].
OBJECTIVE
Evaluate the antinociceptive effects of subarachnoid meloxicam on the mechanical hypernociception induced by carrageenan in rats.


METHODS
Randomized controlled trial. Eighteen adult male Wistar rats underwent a cannula implantation into the subarachnoid space and were randomly divided into two groups: Group I (GI) received saline solution 5μL, while Group II (GII) received meloxicam 30mg. The mechanical hypernociception was induced by intraplantar injection of carrageenan and evaluated using a digital analgesymeter every 30minutes during a 4 hour period. The results were recorded as the Δ withdrawal threshold (in g), calculated by subtracting the measurement value after


RESULTS
The Δ withdrawal threshold mean values were lower in the group of patients treated with meloxicam over all time points between 45 and 165minutes, however, there was no statistical significance, (p=0.835) for this difference.


CONCLUSIONS
Subarachnoid meloxicam at a dose of 30μg.animal(-1) did not suppress the mechanical hypernociception in a model of inflammatory pain induced by intraplantar administration of carrageenan in rats. The data suggest that other dosages should be investigated the drug effect is discarded.
Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. Electronic address: lanucha_moura@terra.com.br.
Lanucha Fidelis da Luz
LF
Moura
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Silvana Bellini
SB
Vidor
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Anelise Bonilla
AB
Trindade
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Priscilla Domingues
PD
Mörschbächer
Universidade do Estado de Santa Catarina, Florianópolis, SC, Brasil.
Nilson
N
Oleskovicz
Faculdade de Veterinária da Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil.
Emerson Antonio
EA
Contesini
AINE; Carrageenan; Carragenina; Dor; Medula espinhal; NSAIDs; Pain; Spinal cord