Antiproliferative effect of valproic acid and 5,7-dimethoxycoumarin against A2058 human melanoma cells.
Melanoma is one of the most malignant tumors of a dangerous high incidence and high metastatic potential. It grows quickly and in an advanced stage is resistant to radio-, chemo- and immunotherapy, which makes it difficult to cure. Therefore, research efforts are focused on the development of new therapeutics or chemopreventive strategies. The aim of the study was to investigate whether the valproic acid and 5,7-dimethoxycoumarin have an antiproliferative activity against A2058 human melanoma cell line. Investigated compounds inhibited the proliferation of cells, however, no synergistic effect of their co-administration was observed.
Daniel
D
Wolny
Ewa
E
Chodurek
Zofia
Z
Dzierzewicz
D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D015394:Molecular Structure; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D003374:Coumarins; D014635:Valproic Acid; C037446:5,7-dimethoxycoumarin