Two new compounds from cultures of the basidiomycete Antrodiella albocinnamomea.
A new linear triterpene (1), and a new sesquiterpene (2), together with a known compound methyl indole-3-carboxylate (3) were isolated from the crude extract of Antrodiella albocinnamomea. The structures of the new compounds 1-2 were determined by comprehensive spectroscopic analysis. Compound 1 exhibited signiﬁcant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 1.0 μg/mL.
a School of Chemistry and Chemical Engineering, Lingnan Normal University , Zhanjiang 524048 , P.R. China.
Zi-Ming
ZM
Chen
Shun-Lin
SL
Wang
D001487:Basidiomycota / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D014315:Triterpenes; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
Antrodiella albocinnamomea; linear triterpene; protein tyrosine phosphatase 1B; sesquiterpene