Remote ischemic conditioning: a novel way to treat ischemia-related injury of limbs.
Remote ischemic conditioning (RIC) including remote ischemic preconditioning (RIPC) and remote ischemic postconditioning (RIPostC) is widely reported to be able to prevent many organs, such as heart, brain, and skeletal muscle from ischemia-related injury. However, the clinical application of RIC is confined to treating myocardial infarction and stroke. Since RIC could prevent skeletal muscle from ischemia-related injury, and was effective in heart and brain treatments, we hypothesized RIC could treat ischemia-related injury of limbs, such as diabetic foot, Buerger's disease, plantation of severed limb, and crush injury. As we know, many researches not only proved the promising clinical applications of RIC, but also researched the mechanisms in animal models. Our hypothesis could be confirmed by these researches.
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Li
L
Tengfei
Department of Orthopedics, Beijing Shijitan Hospital, Capital Medical University, The 9th Clinical College, PKU, Beijing, China. Electronic address: wangjiangning1234@163.com.
Wang
W
Jiangning
D005121:Extremities / Q000503:physiopathology*; D006801:Humans; D057775:Ischemic Postconditioning / Q000379:methods*; D008954:Models, Biological; D015428:Myocardial Reperfusion Injury / Q000628:therapy*