Epidemiology of invasive fungal diseases among patients with haematological disorders in the Asia-Pacific: a prospective observational study.
We conducted a 2-year multicentre prospective observational study to determine the epidemiology of and mortality associated with invasive fungal diseases (IFDs) among patients with haematological disorders in Asia. Eleven institutions from 8 countries/regions participated, with 412 subjects (28.2% possible, 38.3% probable and 33.5% proven IFDs) recruited. The epidemiology of IFDs in participating institutions was similar to Western centres, with Aspergillus spp. (65.9%) or Candida spp. (26.7%) causing the majority of probable and proven IFDs. The overall 30-day mortality was 22.1%. Progressive haematological disorder (odds ratio [OR] 5.192), invasive candidiasis (OR 3.679), and chronic renal disease (OR 6.677) were independently associated with mortality.
National University Hospital, National University Health System, Singapore. Electronic address: liyang_hsu@yahoo.com.
L Y
LY
Hsu
Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
D G
DG
Lee
China Medical University Hospital, Taiwan.
S P
SP
Yeh
Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
D
D
Bhurani
National Institute of Hematology and Blood Transfusion, Hanoi, Viet Nam.
B Q
BQ
Khanh
Singapore General Hospital, Singapore.
C Y
CY
Low
Maharaj Nakorn Chiang Mai Hospital, Thailand.
L
L
Norasetthada
Queen Mary Hospital, Hong Kong Special Administrative Region, China.
T
T
Chan
Queen Mary Hospital, Hong Kong Special Administrative Region, China.
Y L
YL
Kwong
Maedanta Medicity, Gurgaon, India.
A K
AK
Vaid
National Kidney and Transplant Institute, Quezon City, Philippines.
I
I
Alejandria
National Kidney and Transplant Institute, Quezon City, Philippines.
M
M
Mendoza
National Taiwan University Hospital, Taiwan.
C Y
CY
Chen
International Health Management Associates, Inc., Schaumburg, IL, USA.
A
A
Johnson
Changi General Hospital, Singapore.
T Y
TY
Tan
D000328:Adult; D001210:Asia, Southeastern / Q000453:epidemiology; D001230:Aspergillus / Q000302:isolation & purification; D002175:Candida / Q000302:isolation & purification; D005260:Female; D016469:Fungemia / Q000453:epidemiology* / Q000401:mortality; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010139:Pacific Islands / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D016019:Survival Analysis
Antifungal agents; Asia-Pacific; epidemiology; haematological diseases; invasive fungal disease