Infectious complications in bullous pemphigoid: an analysis of risk factors.
BACKGROUND
Infections are common in bullous pemphigoid and contribute to significant mortality.


OBJECTIVE
We sought to define the spectrum of infectious complications and to identify associated risk factors in a bullous pemphigoid cohort.


METHODS
A retrospective cohort study conducted at an academic medical center.


RESULTS
In all, 97 patients were included. Infectious complications occurred in 54 patients (56%) and the median duration from diagnosis to first episode of infection was 3 months. Bacteremia occurred in 14 patients (26%) and 26 of 30 deaths (87%) were attributable to infections. On univariate analysis, significant risk factors include low Karnofsky score (<60) (odds ratio [OR] 3.5, 95% confidence interval [CI] 1.5-8.3; P < .01), high Charlson comorbidity index score (≥6) (OR 2.4, 95% CI 1.1-5.5; P = .04), and dementia (OR 4.9, 95% CI 1.5-15.8; P = .01). On multivariate analysis, low Karnofsky score and dementia remained significant with an OR of 3.3 (95% CI 1.1-10.0; P = .03) and OR of 4.2 (95% CI 1.2-14.7; P = .03), respectively.


CONCLUSIONS
Limitations include potential selection bias as a result of study design and primary outcome measures focused on significant infections requiring hospitalizations. Minor infections were not included.


CONCLUSIONS
Identified risk factors for infectious complications include functional impairment and the presence of dementia, which may allow for better risk stratification and individualized treatment of bullous pemphigoid.
Department of Dermatology, Singapore General Hospital, Singapore.
Yee Wei
YW
Phoon
Health Services Research and Biostatistics, Division of Research, Singapore General Hospital, Singapore.
Stephanie M C
SM
Fook-Chong
Department of Dermatology, Singapore General Hospital, Singapore.
Hong Yi
HY
Koh
Department of Dermatology, Singapore General Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore.
Thamotharampillai
T
Thirumoorthy
Department of Dermatology, Singapore General Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore.
Shiu Ming
SM
Pang
Department of Dermatology, Singapore General Hospital, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore. Electronic address: lee.haur.yueh@sgh.com.sg.
Haur Yueh
HY
Lee
D000368:Aged; D016470:Bacteremia / Q000209:etiology; D015331:Cohort Studies; D003704:Dementia / Q000150:complications; D005260:Female; D006801:Humans; D007239:Infections / Q000209:etiology*; D017567:Karnofsky Performance Status; D008297:Male; D010391:Pemphigoid, Bullous / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors
bullous pemphigoid; dementia; infectious complications; low Karnofsky score; morbidity; mortality; risk factors