Copper-catalyzed oxidative C(sp(3))-H/N-H coupling of sulfoximines and amides with simple alkanes via a radical process.
A copper-catalyzed oxidative C(sp(3))-H/N-H coupling of sulfoximines with simple alkanes was developed. This protocol involved C(sp(3))-N bond formation via a radical pathway and tolerated a series of functional groups, such as chloro, methyl and aryl, on the phenyl rings. Apart from sulfoximines, amides, saccharin and aniline also worked well to give the corresponding N-alkylated products.
School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn jiangcheng@cczu.edu.cn.
Fan
F
Teng
Song
S
Sun
Yan
Y
Jiang
Jin-Tao
JT
Yu
Jiang
J
Cheng