[Test scores as indicators of treatment efficacy in dementia caused by Alzheimer's disease in clinical practice].
OBJECTIVE
To analyze the possibility of using MMSE and CGIS as well as the Clock drawing test for the objectification of treatment efficacy in Alzheimer's disease (AD).


METHODS
Authors examined 765 patients with mild and moderate dementia treated with donepezil during 3 months. The efficacy was assessed using the MMSE and CGIS.


CONCLUSIONS
The methods demonstrated the reproducibility compared to those used in earlier clinical trials and efficacy of donepezile in the treatment of mild and moderate AD, the Clock drawing test can be recommended as an additional technique for assessment of treatment efficacy in relation to opticospatial function.
Otdel geriatricheskoĭ psikhiatrii, otdelenie bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
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Gavrilova
Otdel geriatricheskoĭ psikhiatrii, otdelenie bolezni Al'tsgeĭmera i assotsiirovannykh s neĭ rasstroĭstv FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
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Kolykhalov
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010880:Piperidines / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil