Enhancement of transdermal delivery of ibuprofen using microemulsion vehicle.
OBJECTIVE
The objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability.


METHODS
Microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. Pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. The effects of oleic acid and surfactant mixture on skin permeation of ibuprofen were evaluated with excised skins.


RESULTS
The optimum formulation F3 consisting of 6% oleic acid, 30% Cremophor RH40/Transcutol P (2:1, w/w) and 59% water phase, showed a high permeation rate of 42.98 µg/cm(2)/hr. The mean droplet size of microemulsion was about 43 nm and no skin irritation signs were observed on the skin of rabbits.


CONCLUSIONS
These results indicated that this novel microemulsion is a useful formulation for the transdermal delivery of ibuprofen.
College of Pharmaceutical Sciences, Hebei University, Baoding, China ; Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China.
Liandong
L
Hu
College of Pharmaceutical Sciences, Hebei University, Baoding, China ; NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People's Republic of China.
Qiaofeng
Q
Hu
College of Pharmaceutical Sciences, Hebei University, Baoding, China ; NBP Pharmaceutical Company Limited, CSPC Pharmaceutical Group Limited, Shijiazhuang 052165, People's Republic of China.
Jianxue
J
Yang
Ibuprofen; Microemulsion; Skin permeability; Transdermal