Genetic susceptibility to prosthetic joint infection following total joint arthroplasty: A systematic review.
BACKGROUND
Prosthetic joint infection (PJI) is the most common cause of total joint arthroplasty failure and revision surgery. Genetic polymorphisms could be determinant factors for PJI.


METHODS
We performed a systematic research of Medline, Pubmed, Embase, Cochrane Library, and Google Scholar, and identified 11 studies with 34 kinds of gene polymorphisms, were included in the synthesis.


RESULTS
Our data suggest that the C allele and genotype C/C for MBL-550 SNP, genotype A/A for MBL-54 SNP and G allele for MBL-221 SNP increase the risk of PJI, while G allele and genotype G/G for MBL-550 SNP decrease the risk of PJI in Caucasian populations. Several other genes reported by single-center studies also contribute to the genetic susceptibility to septic PJI. No definitive conclusions could be achieved due to the small amount of data in the included studies.


CONCLUSIONS
Several genes contribute to the genetic susceptibility to PJI following total joint arthroplasty. Further studies will enhance the understanding of PJI, and may inform and direct early interventions.
Department of Orthopedics Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
Xindie
X
Zhou
Department of Orthopedics Surgery, Zhongshan Hospital, Fudan University, Shanghai 200000, China.
Mumingjiang
M
Yishake
Department of Orthopedics Surgery, The Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310000, China.
Jin
J
Li
Department of Orthopedics Surgery, The Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310000, China.
Lifeng
L
Jiang
Department of Orthopedics Surgery, The Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310000, China.
Lidong
L
Wu
Department of Orthopedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China. Electronic address: lrp216@sina.com.
Ruiping
R
Liu
Department of Orthopedics Surgery, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China. Electronic address: xunanwei@sina.com.
Nanwei
N
Xu
D001178:Arthroplasty / Q000009:adverse effects*; D016207:Cytokines / Q000235:genetics; D004798:Enzymes / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000235:genetics*; D044465:White People / Q000235:genetics
D016207:Cytokines; D004798:Enzymes; D037601:Mannose-Binding Lectin
Polymorphism; Prosthetic joint infection; SNP; Systematic review; Total joint arthroplasty