Magnetic nanoparticles: Applications in gene delivery and gene therapy.
Gene therapy is defined as the direct transfer of genetic material to tissues or cells for the treatment of inherited disorders and acquired diseases. For gene delivery, magnetic nanoparticles (MNPs) are typically combined with a delivery platform to encapsulate the gene, and promote cell uptake. Delivery technologies that have been used with MNPs contain polymeric, viral, as well as non-viral platforms. In this review, we focus on targeted gene delivery using MNPs.
b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|c Higher Academic Education Institute of Rabe Rashid , Tabriz , Iran.
Sima
S
Majidi
b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|c Higher Academic Education Institute of Rabe Rashid , Tabriz , Iran.
Fatemeh
F
Zeinali Sehrig
b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|e Department of Endodontics , Faculty of Dentistry, Tabriz University of Medical Sciences , Tabriz , Iran.
Mohammad
M
Samiei
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Morteza
M
Milani
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Elham
E
Abbasi
d Department of Laboratory Sciences , Marand Branch, Islamic Azad University , Marand , Iran.
Kianoosh
K
Dadashzadeh
a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Abolfazl
A
Akbarzadeh
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D060526:Magnetic Fields; D053758:Nanoparticles / Q000737:chemistry*
cell uptake; gene therapy; magnetic nanoparticles; non-viral platforms