Solution combustion synthesis of calcium phosphate particles for controlled release of bovine serum albumin.
Four different phase compositions of calcium phosphate (CaP) particles were prepared via a solution combustion method. X-ray diffraction (XRD) and Rietveld analysis results revealed that the variations in the nominal Ca/P (molar) ratios were found to provide a favorable control in the different proportions of CaP materials. Bovine serum albumin (BSA) was used as a model protein to study the loading and release behavior. The release profile indicated that the BSA release rates depended on the phase compositions of the CaP particles, and showed an order of TCP-BSA>BCP-1-BSA>BCP-2-BSA>HA-BSA. The results suggested that the BSA protein release rate can be controlled by varying the phase compositions of CaP carriers. Moreover, the release process involved two stages: firstly surface diffusion via ion exchange and secondly intraparticle diffusion.
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China; Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu, PR China. Electronic address: daidai02304@163.com.
Junfeng
J
Zhao
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Junjie
J
Zhao
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Yu
Y
Qian
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Xiali
X
Zhang
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Feifei
F
Zhou
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Hong
H
Zhang
National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences, Nanjing University, Nanjing, PR China.
Hongbin
H
Lu
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China; Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu, PR China.
JianHua
J
Chen
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China; Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu, PR China.
XuHong
X
Wang
School of Chemistry and Materials Engineering, Changshu Institute of Technology, Changshu, PR China.
Wencong
W
Yu
D000327:Adsorption; D000818:Animals; D002130:Calcium Phosphates / Q000138:chemical synthesis*; D002417:Cattle; D003692:Delayed-Action Preparations; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D012996:Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D012996:Solutions; D012710:Serum Albumin, Bovine; C020243:calcium phosphate
BSA; Calcium phosphate (CaP); Controlled release; Phase transformation; Thermal analysis