Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn107Ile) with impulsivity and hyperactivity.
Administration of neuropeptide S (NPS) elicits anxiolysis, arousal and higher activity in rodents. In humans, the NPS receptor (NPSR1) gene rs324981 A/T (Asn(107)Ile) polymorphism is associated with fear responses and anxiety. We have recently revealed an association of NPSR1 with impulsivity-related traits and psychopathology. In the present study the association of the NPSR1 genotype with impulsivity and attention-deficit/hyperactivity disorder (ADHD)-related symptoms was re-examined in two independent non-clinical cohorts. We used self-reports of two population-derived samples of the Estonian Psychobiological Study of Traffic Behaviour (EPSTB): a community car driving sample (n=491, MAge=37) and a driving school student sample (n=773, MAge=24). Impulsivity was measured with the Adaptive and Maladaptive Impulsivity Scale (AMIS) in both samples, and with the Barratt Impulsivity Scale (BIS) in driving schools only. For the latter sample, also measurement of ADHD symptoms was carried out with the Adult ADHD Self-Report Scale (ASRS). NPSR1 T-allele carriers had higher scores of impulsivity, motor restlessness and total ADHD scores. The effect on impulsivity originated from male participants but for ADHD symptoms the association was independent of sex. Thus we have confirmed in two additional population-derived samples that the T-allele of the NPSR1 rs324981 polymorphism is associated with increased impulsivity and ADHD-related traits.
Division of Neuropsychopharmacology, University of Tartu, Tartu, Estonia.
Kariina
K
Laas
Department of Public Health, University of Tartu, Tartu, Estonia.
Diva
D
Eensoo
Division of Neuropsychopharmacology, University of Tartu, Tartu, Estonia.
Marika
M
Paaver
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany Department of Translational Neuroscience, Maastricht University, Maastricht, the Netherlands.
Klaus-Peter
KP
Lesch
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.
Andreas
A
Reif
Division of Neuropsychopharmacology, University of Tartu, Tartu, Estonia Jaanus.Harro@ut.ee.
Jaanus
J
Harro
D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D001334:Automobile Driving; D015331:Cohort Studies; D004957:Estonia; D005260:Female; D005838:Genotype; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics*; D007175:Impulsive Behavior / Q000502:physiology*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012737:Sex Factors; D055815:Young Adult
C484532:NPSR1 protein, human; D043562:Receptors, G-Protein-Coupled
Impulsivity; NPSR1; attention-deficit/hyperactivity disorder; hyperactivity; neuropeptide S; neuropeptide S receptor; personality