Langerhans cell histiocytosis or tuberculosis on a medieval child (Oppidum de la Granède, Millau, France - 10th-11th centuries AD).
In 2008, a skeleton of a 1 - 2.5-year-old child radiocarbon dated from the 10th - 11th century AD was discovered on the oppidum of La Granède (Millau, France). It presents multiple cranial osteolytic lesions having punched-out or geographical map-like aspects associated with sequestrum and costal osteitis. A multi 3D digital approach (CT, μCT and virtual reconstruction) enabled us to refine the description and identify the diploic origin of the lytic process. Furthermore, precise observation of the extent of the lesions and associated reorganization of the skeletal micro-structure were possible. From these convergent pieces of evidence, the differential diagnosis led to three possibilities: Langerhans cell histiocytosis, tuberculosis, or Langerhans cell histiocytosis and tuberculosis.
UMR 5199 PACEA, Univ. Bordeaux, Bâtiment B8, Allée Geoffroy Saint-Hilaire, CS 50023, F-33615 Pessac Cedex, France. Electronic address: a.colombo@pacea.u-bordeaux1.fr.
Antony
A
Colombo
Service Archéologique Départemental d'Aveyron, 12 Boulevard des Balquières, F-12850 Onet-le-Château, France. Electronic address: christophe.saintpierre@cg12.fr.
Christophe
C
Saint-Pierre
UMR 5199 PACEA, Univ. Bordeaux, Bâtiment B8, Allée Geoffroy Saint-Hilaire, CS 50023, F-33615 Pessac Cedex, France. Electronic address: stephan_naji@hotmail.com.
Stephan
S
Naji
Department of Medical Imaging, University Hospital of Marseille, Chemin de Bourrelys, F-13915 Marseille Cedex 20, France. Electronic address: Michel.PANUEL@ap-hm.fr.
Michel
M
Panuel
UMR 5199 PACEA, Univ. Bordeaux, Bâtiment B8, Allée Geoffroy Saint-Hilaire, CS 50023, F-33615 Pessac Cedex, France; Max Planck Institute, Department of Human Evolution, Deutscher Platz 6, 04103 Leipzig, Germany. Electronic address: h.coqueugniot@pacea.u-bordeaux1.fr.
Hélène
H
Coqueugniot
UMR 5199 PACEA, Univ. Bordeaux, Bâtiment B8, Allée Geoffroy Saint-Hilaire, CS 50023, F-33615 Pessac Cedex, France; Laboratoire d'Anthropologie Biologique Paul Broca, Ecole Pratique des Hautes Etudes, Univ. Bordeaux, Bâtiment B8, Avenue des Facultés, F-33400 Talence, France; Department of Anthropology, University of Western Ontario, Canada. Electronic address: olivier.dutour@ephe.sorbonne.fr.
Olivier
O
Dutour
D002675:Child, Preschool; D003937:Diagnosis, Differential; D005602:France; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology*; D049691:History, Medieval; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D010164:Paleopathology; D014394:Tuberculosis, Osteoarticular / Q000473:pathology*
3D reconstruction; Langerhans cell histiocytosis; Medical imaging; Medieval period; Tuberculosis