Chemopreventive effects of hydatid disease on experimental breast cancer.
Breast cancer is one of the most common and letal cancers in all over the world. Since there have been significant improvements in treatment of breast cancer, there is still a big need for alternative approaches. In this study, we aimed to investigate protective role of hydatid disease against breast cancer. Twenty Wistar rats were divided into two groups of 10 rats each Group I (control) and Group II. In Group II intraperitoneal hydatidosis was performed. Then DMBA was applied to mammary tissues of all rats. Immunohistochemistry studies for Ki-67 and S-100 in the tumoral tissue sections of DMBA induced mammary tumor in rats were performed. TUNEL Assay was used to detect apoptotic cells of tumoral tissue. In vivo anticancer activity testing was carried out by preventing the tumorigenesis by DMBA in mammary tissue of rats. The expressions of the Ki-67 and S-100 protein decreased in rats who had Hydatid Disease (HD) (Group II), compared with the control rats (Group I). TUNEL positive cells were higher in rats with HD (Group II), compared with the control rats (Group I). In vivo studies showed that HD prevented the tumorigenesis by DMBA in mammary tissue of rats with 50 percent.In the light of the evidence the present study showed that HD may have chemopreventive effects on DMBA induced breast cancer.
Department of Pharmacology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey E-mail : md.ahmetaltun@gmail.com.
Ahmet
A
Altun
Serpil Unver
SU
Saraydin
Sinan
S
Soylu
Deniz Sahin
DS
Inan
Cinar
C
Yasti
Yasar
Y
Ozdenkaya
Binnur
B
Koksal
Cevdet
C
Duger
Cemil
C
Isbir
Mustafa
M
Turan
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis; D002273:Carcinogens / Q000633:toxicity; D004443:Echinococcosis / Q000635:transmission*; D048209:Echinococcus granulosus / Q000502:physiology*; D005260:Female; D007124:Immunoenzyme Techniques; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene