Sarcopenia and fragility fractures: molecular and clinical evidence of the bone-muscle interaction.
➤ Bone and muscle tissues are in close relationship, and the aging process is a factor involved in the loss of the functionality of both bones and muscles.➤ Sarcopenia and osteoporosis are linked from a biological and functional perspective and are related to an increased fracture risk in the elderly.➤ The increased fracture risk in sarcopenic and osteoporotic subjects is due to the decline of muscle mass and strength, the decrease in bone mineral density, and limited mobility.
Department of Orthopaedics and Traumatology, University Hospital Foundation, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. E-mail address for U. Tarantino: umberto.tarantino@uniroma2.it.
Umberto
U
Tarantino
Department of Orthopaedics and Traumatology, University Hospital Foundation, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. E-mail address for U. Tarantino: umberto.tarantino@uniroma2.it.
Eleonora
E
Piccirilli
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome Italy.
Massimo
M
Fantini
Department of Orthopaedics and Traumatology, University Hospital Foundation, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. E-mail address for U. Tarantino: umberto.tarantino@uniroma2.it.
Jacopo
J
Baldi
Department of Orthopaedics and Traumatology, University Hospital Foundation, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy. E-mail address for U. Tarantino: umberto.tarantino@uniroma2.it.
Elena
E
Gasbarra
Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata," Via Montpellier 1, 00133 Rome Italy.
Roberto
R
Bei
D015502:Absorptiometry, Photon; D000058:Accidental Falls / Q000706:statistics & numerical data; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000473:pathology; D010024:Osteoporosis / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology*; D015995:Prevalence; D055948:Sarcopenia / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology*