Optimization of a planar all-polymer transistor for characterization of barrier tissue.
The organic electrochemical transistor (OECT) is a unique device that shows great promise for sensing in biomedical applications such as monitoring of the integrity of epithelial tissue. It is a label-free sensor that is amenable to low-cost production by roll-to-roll or other printing technologies. Herein, the optimization of a planar OECT for the characterization of barrier tissue is presented. Evaluation of surface coating, gate biocompatibility and performance, and optimization of the geometry of the transistor are highlighted. The conducting polymer poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate), which is used as the active material in the transistor, has the added advantage of allowing significant light transmission compared to traditional electrode materials and thus permits high-quality optical microscopy. The combination of optical and electronic monitoring of cells shown herein provides the opportunity to couple two very complementary techniques to yield a low-cost method for in vitro cell sensing.
Department of Bioelectronics, Ecole Nationale Supérieure des Mines CMP-EMSE, 880 route de Mimet, 13541 Gardanne (France). ramuz@emse.fr.
Marc
M
Ramuz
Kaleigh
K
Margita
Adel
A
Hama
Pierre
P
Leleux
Jonathan
J
Rivnay
Ingrid
I
Bazin
Róisín M
RM
Owens
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000378:metabolism; D004285:Dogs; D055664:Electrochemical Techniques; D004566:Electrodes; D004847:Epithelial Cells / Q000737:chemistry* / Q000378:metabolism; D061985:Madin Darby Canine Kidney Cells; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011137:Polystyrenes / Q000737:chemistry* / Q000378:metabolism
D019086:Bridged Bicyclo Compounds, Heterocyclic; D011108:Polymers; D011137:Polystyrenes; C121383:poly(3,4-ethylene dioxythiophene); C003321:polystyrene sulfonic acid
barrier tissue; conducting polymers; electrochemistry; organic electrochemical transistors; sensors