Metabolic syndrome: An independent risk factor for erectile dysfunction.
OBJECTIVE
The objective was to determine the role of various components of metabolic syndrome (MetS) as independent risk factor for erectile dysfunction (ED).


METHODS
A total of 113 subjects of MetS, as recommended by recent IDF and AHA/NHLBI joint interim statement were selected for study who presented for ED. After doing Anthropometric examination, fasting laboratory assay for fasting plasma glucose (FPG), fasting insulin, hemoglobin A1c, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and 2 h oral glucose tolerance test (OGTT) was done. Erectile function was assessed by completing questions one through five of the International Index of Erectile Function (IIEF-5). A multiple linear regression analysis was carried out on 66 subjects with IIEF-5 score as dependent variable and components of MetS FPG, 2 h OGTT, TG, HDL, and waist circumference as independent variables.


RESULTS
Using a multiple linear regression analysis, we observed that presence of the various components of MetS was associated with ED and a decrease IIEF-5 score and this effect was greater than the effect associated with any of the individual components. Of the individual components of the MetS, HDL (B = 0.136; P = 0.004) and FPG (B = -0.069; P = 0.007) conferred the strongest effect on IIEF-5 score. However, overall age had most significant effect on IIEF-5 score.


CONCLUSIONS
It is crucial to formulate strategies and implement them to prevent or control the epidemic of the MetS and its consequences. The early identification and treatment of risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions.
Department of Endocrinology, LLRM Medical College, Meerut, India.
Saran
S
Sanjay
Department of Biochemistry, Subharti Medical College, Meerut, India.
Gupta Sona
GS
Bharti
Department of Endocrinology, LLRM Medical College, Meerut, India.
Gutch
G
Manish
Department of Endocrinology, Pushpagiri Medical College Thiruvalla, Kerala.
Philip
P
Rajeev
Department of Endocrinology, Hormone Care and Research Centre, Ghaziabad, Uttar Pradesh, India.
Agrawal
A
Pankaj
Department of Ophthalmology, Subharti Medical College, Meerut, India.
Agroiya
A
Puspalata
Department of Endocrinology, LLRM Medical College, Meerut, India.
Gupta
G
Keshavkumar
Erectile dysfunction; international index of erectile function 5 score; metabolic syndrome