The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.
A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6h a day. Parameters of the morphological and functional states of the organs studied were measured and biochemical and enzyme-immunoassays were carried out on the first and second days. This study reveals that the main mechanism by which the L17 compound mediates of its anti-stress was by activation of macrophages on the second day of the experiments and the inhibition of apoptosis in the thymus. The results enable us to suggest that the compound L17 does not improve resistance to stress; however, it does lower the reaction to stress.
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia.
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Sarapultsev
The IJ Postovsky Institute of Organic Synthesis of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia.
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Chupakhin
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia.
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Medvedeva
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia.
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Mukhlynina
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia.
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Brilliant
Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia.
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Sidorova
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia.
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Danilova
Institute of Immunology and Physiology of the Ural Branch of the RAS, Russia; Federal State Autonomous Educational Institution of Higher Professional Education, Ural Federal University named after the first President of Russia B. N. Yeltsin, Russia. Electronic address: a.sarapultsev@gmail.com.
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Sarapultsev
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D051381:Rats; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013312:Stress, Physiological / Q000187:drug effects / Q000276:immunology*; D013829:Thiadiazines / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology
D001786:Blood Glucose; D007155:Immunologic Factors; D013829:Thiadiazines; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003345:Corticosterone
6H-1,3,4-Thiadiazine; Anti-stress agents; L-17 compound; Stress; Thiadiazines