Characterization of large structural genetic mosaicism in human autosomes.
Analyses of genome-wide association study (GWAS) data have revealed that detectable genetic mosaicism involving large (>2 Mb) structural autosomal alterations occurs in a fraction of individuals. We present results for a set of 24,849 genotyped individuals (total GWAS set II [TGSII]) in whom 341 large autosomal abnormalities were observed in 168 (0.68%) individuals. Merging data from the new TGSII set with data from two prior reports (the Gene-Environment Association Studies and the total GWAS set I) generated a large dataset of 127,179 individuals; we then conducted a meta-analysis to investigate the patterns of detectable autosomal mosaicism (n = 1,315 events in 925 [0.73%] individuals). Restricting to events >2 Mb in size, we observed an increase in event frequency as event size decreased. The combined results underscore that the rate of detectable mosaicism increases with age (p value = 5.5 × 10(-31)) and is higher in men (p value = 0.002) but lower in participants of African ancestry (p value = 0.003). In a subset of 47 individuals from whom serial samples were collected up to 6 years apart, complex changes were noted over time and showed an overall increase in the proportion of mosaic cells as age increased. Our large combined sample allowed for a unique ability to characterize detectable genetic mosaicism involving large structural events and strengthens the emerging evidence of non-random erosion of the genome in the aging population.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Mitchell J
MJ
Machiela
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Weiyin
W
Zhou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Joshua N
JN
Sampson
Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, MD 21702, USA.
Michael C
MC
Dean
Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA; BioInformed LLC, Gaithersburg, MD 20877, USA.
Kevin B
KB
Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Amanda
A
Black
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Louise A
LA
Brinton
National Institute of Cancer Research, National Health Research Institutes, Zhunan 35053, Taiwan, ROC.
I-Shou
IS
Chang
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Chu
C
Chen
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA.
Constance
C
Chen
Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300040, People's Republic of China.
Kexin
K
Chen
University of New Mexico, Albuquerque, NM 87131, USA.
Linda S
LS
Cook
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Marta
M
Crous Bou
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Immaculata
I
De Vivo
Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA.
Jennifer
J
Doherty
Department of Population Health Research, CancerControl Alberta, Alberta Health Services, Calgary, AB T2N 2T9, Canada.
Christine M
CM
Friedenreich
Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Mia M
MM
Gaudet
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Christopher A
CA
Haiman
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Susan E
SE
Hankinson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Patricia
P
Hartge
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Brian E
BE
Henderson
Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
Yun-Chul
YC
Hong
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
H Dean
HD
Hosgood
Institute of Population Health Sciences, National Health Research Institutes, Zhunan 35053, Taiwan, ROC.
Chao A
CA
Hsiung
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Wei
W
Hu
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
David J
DJ
Hunter
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Lea
L
Jessop
Center for Creative Biomedical Scientists, Chonnam National University, Gwangju 500-757, Republic of Korea.
Hee Nam
HN
Kim
Division of Oncology/Hematology, Department of Internal Medicine, College of Medicine, Korea University Anam Hospital, Seoul 151-742, Republic of Korea.
Yeul Hong
YH
Kim
Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, College of Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
Young Tae
YT
Kim
Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Robert
R
Klein
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA.
Peter
P
Kraft
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Qing
Q
Lan
Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China.
Dongxin
D
Lin
Department of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore; School of Life Sciences, Anhui Medical University, Hefei 230032, People's Republic of China.
Jianjun
J
Liu
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Loic
L
Le Marchand
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Xiaolin
X
Liang
Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw 02-781, Poland.
Jolanta
J
Lissowska
Yale School of Public Health, New Haven, CT 06510, USA.
Lingeng
L
Lu
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Anthony M
AM
Magliocco
Department of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 819-0395, Japan.
Keitaro
K
Matsuo
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Sara H
SH
Olson
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Irene
I
Orlow
Lung Cancer Center, Kyungpook National University Medical Center, Daegu 101, Republic of Korea.
Jae Yong
JY
Park
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.
Loreall
L
Pooler
Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jennifer
J
Prescott
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Radhai
R
Rastogi
Yale School of Public Health, New Haven, CT 06510, USA.
Harvey A
HA
Risch
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Fredrick
F
Schumacher
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore.
Adeline
A
Seow
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Veronica Wendy
VW
Setiawan
Jiangsu Key Laboratory of Cancer Biomarkers, Prevention, and Treatment, Nanjing Medical University, Nanjing 210029, People's Republic of China; Ministry of Education Key Laboratory of Modern Toxicology, Nanjing Medical University, Nanjing 210029, People's Republic of China.
Hongbing
H
Shen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.
Xin
X
Sheng
Department of Preventive Medicine, Chonnam National University Medical School, Gwanju 501-746, Republic of Korea.
Min-Ho
MH
Shin
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Xiao-Ou
XO
Shu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
David
D
VanDen Berg
Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China.
Jiu-Cun
JC
Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nicolas
N
Wentzensen
Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, People's Republic of China.
Maria Pik
MP
Wong
Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, People's Republic of China.
Chen
C
Wu
Institute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan 430400, People's Republic of China.
Tangchun
T
Wu
Guangdong Lung Cancer Institute, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou 515200, People's Republic of China.
Yi-Long
YL
Wu
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.
Lucy
L
Xia
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Hannah P
HP
Yang
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei 10617, Taiwan, ROC.
Pan-Chyr
PC
Yang
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Wei
W
Zheng
Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, People's Republic of China.
Baosen
B
Zhou
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Christian C
CC
Abnet
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Demetrius
D
Albanes
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Thoracic Surgery, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Melinda C
MC
Aldrich
Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Christopher
C
Amos
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Laufey T
LT
Amundadottir
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sonja I
SI
Berndt
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; International Epidemiology Institute, Rockville, MD 20850, USA.
William J
WJ
Blot
Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Cathryn H
CH
Bock
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA.
Paige M
PM
Bracci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Laurie
L
Burdett
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Julie E
JE
Buring
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
Mary A
MA
Butler
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
Tania
T
Carreón
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nilanjan
N
Chatterjee
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Charles C
CC
Chung
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Michael B
MB
Cook
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Michael
M
Cullen
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Faith G
FG
Davis
Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People's Republic of China.
Ti
T
Ding
Unit of Nutrition, Environment, and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute,, Barcelona 08908, Spain.
Eric J
EJ
Duell
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Caroline G
CG
Epstein
Shanghai Cancer Institute, Shanghai 200032, People's Republic of China.
Jin-Hu
JH
Fan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Jonine D
JD
Figueroa
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Joseph F
JF
Fraumeni
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Neal D
ND
Freedman
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Charles S
CS
Fuchs
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotaong University Shanghai 200032, People's Republic of China.
Yu-Tang
YT
Gao
Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Susan M
SM
Gapstur
Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona 31080, Spain.
Ana
A
Patiño-Garcia
Division of Genetics and Epidemiology and Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, Surrey SM2 5NG, UK.
Montserrat
M
Garcia-Closas
Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Massachusetts Veterans Epidemiology Research and Information Center and Cooperative Studies Programs, Veterans Affairs Boston Healthcare System, Boston, MA 02130, USA.
J Michael
JM
Gaziano
Cancer Epidemiology Centre, Cancer Council Victoria and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Graham G
GG
Giles
Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Elizabeth M
EM
Gillanders
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Edward L
EL
Giovannucci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Lynn
L
Goldin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Alisa M
AM
Goldstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Mark H
MH
Greene
Nutritional Research Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå 901 87, Sweden.
Goran
G
Hallmans
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Curtis C
CC
Harris
Department of Oncology, Department of Radiation Sciences, Umeå University, Umeå 901 87, Sweden.
Roger
R
Henriksson
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA.
Elizabeth A
EA
Holly
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Robert N
RN
Hoover
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nan
N
Hu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Amy
A
Hutchinson
International Agency for Research on Cancer, Lyon 69372, France.
Mazda
M
Jenab
Department of Oncology, Finsen Centre, Rigshospitalet, Copenhagen 2100, Denmark; Unit of Survivorship Research, Danish Cancer Society Research Centre, Copenhagen 2100, Denmark.
Christoffer
C
Johansen
School of Clinical Medicine, University of Cambridge, Cambridge CB2 1TN, UK.
Kay-Tee
KT
Khaw
Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore; Duke-NUS Graduate Medical School, Singapore 169857, Singapore.
Woon-Puay
WP
Koh
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Laurence N
LN
Kolonel
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Charles
C
Kooperberg
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy.
Vittorio
V
Krogh
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Robert C
RC
Kurtz
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Andrea
A
LaCroix
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Annelie
A
Landgren
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Maria Teresa
MT
Landi
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Donghui
D
Li
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Linda M
LM
Liao
Spanish National Cancer Research Centre, Madrid 28029, Spain.
Nuria
N
Malats
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Katherine A
KA
McGlynn
Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Lorna H
LH
McNeill
Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Robert R
RR
McWilliams
Department of Oncology, Department of Radiation Sciences, Umeå University, Umeå 901 87, Sweden.
Beatrice S
BS
Melin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Lisa
L
Mirabello
Nofer Institute of Occupational Medicine, Lodz 91-348, Poland.
Beata
B
Peplonska
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ulrike
U
Peters
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Gloria M
GM
Petersen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Ludmila
L
Prokunina-Olsson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Mark
M
Purdue
Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100730, People's Republic of China.
You-Lin
YL
Qiao
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Kari G
KG
Rabe
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Preetha
P
Rajaraman
Spanish National Cancer Research Centre, Madrid 28029, Spain; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain.
Francisco X
FX
Real
Division of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Elio
E
Riboli
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona 08003, Spain; Quantitative Genomic Medicine Laboratory, qGenomics, Barcelona 08003, Spain.
Benjamín
B
Rodríguez-Santiago
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nathaniel
N
Rothman
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
Avima M
AM
Ruder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sharon A
SA
Savage
Karmanos Cancer Institute and Department of Oncology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Ann G
AG
Schwartz
Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Kendra L
KL
Schwartz
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Howard D
HD
Sesso
Cancer Epidemiology Centre, Cancer Council Victoria and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia; Human Genetics Foundation, Torino 10126, Italy.
Gianluca
G
Severi
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Debra T
DT
Silverman
Baylor College of Medicine, Houston, TX 77030, USA.
Margaret R
MR
Spitz
Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Victoria L
VL
Stevens
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Rachael
R
Stolzenberg-Solomon
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Daniel
D
Stram
Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, People's Republic of China.
Ze-Zhong
ZZ
Tang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Philip R
PR
Taylor
Epidemiology Research Program, American Cancer Society, Atlanta, GA 30303, USA.
Lauren R
LR
Teras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Geoffrey S
GS
Tobias
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA.
Kala
K
Viswanathan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Sholom
S
Wacholder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Zhaoming
Z
Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Stephanie J
SJ
Weinstein
Information Management Services Inc., Calverton, MD 20904, USA.
William
W
Wheeler
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Emily
E
White
University of California, San Francisco, San Francisco, CA 94143, USA.
John K
JK
Wiencke
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Brian M
BM
Wolpin
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xifeng
X
Wu
Division of Urologic Surgery, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Jay S
JS
Wunder
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Kai
K
Yu
Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Krista A
KA
Zanetti
Department of Population Health, School of Medicine, New York University, New York, NY 10016, USA; Perlmutter Cancer Institute, New York University, New York, NY 10016, USA.
Anne
A
Zeleniuch-Jacquotte
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Regina G
RG
Ziegler
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Mariza
M
de Andrade
School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Kathleen C
KC
Barnes
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218, USA.
Terri H
TH
Beaty
Department of Psychiatry, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
Laura J
LJ
Bierut
Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI 48109, USA.
Karl C
KC
Desch
Center for Inherited Disease Research, Institute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA.
Kimberly F
KF
Doheny
Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
Bjarke
B
Feenstra
Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
David
D
Ginsburg
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
John A
JA
Heit
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Jae H
JH
Kang
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cecilia A
CA
Laurie
Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Jun Z
JZ
Li
Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA.
William L
WL
Lowe
Center for Craniofacial and Dental Genetics, Department of Oral Biology School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Mary L
ML
Marazita
Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Mads
M
Melbye
Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Daniel B
DB
Mirel
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
Jeffrey C
JC
Murray
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Sarah C
SC
Nelson
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA 02114, USA.
Louis R
LR
Pasquale
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Kenneth
K
Rice
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA 02114, USA.
Janey L
JL
Wiggs
Office of Population Genomics, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Anastasia
A
Wise
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Margaret
M
Tucker
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras, Barcelona 08003, Spain; Hospital del Mar Research Institute, Barcelona 08003, Spain.
Luis A
LA
Pérez-Jurado
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Cathy C
CC
Laurie
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Neil E
NE
Caporaso
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Leidos Biomedical Research Inc., Bethesda, MD 20892, USA.
Meredith
M
Yeager
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: chanocks@mail.nih.gov.
Stephen J
SJ
Chanock
D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D009369:Neoplasms / Q000235:genetics