Synthesis of 3-bromosubstituted pyrroles via palladium-catalyzed intermolecular oxidative cyclization of bromoalkynes with N-allylamines.
This paper describes a novel palladium-catalyzed oxidative cyclization of bromoalkynes with N-allylamines via cascade formation of C-N and C-C bonds. During this process, the bromine atom was retained to form 3-bromo-pyrroles, which can undergo the subsequent structural modifications.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. jianghf@scut.edu.cn.
Jia
J
Zheng
Liangbin
L
Huang
Zun
Z
Li
Wanqing
W
Wu
Jianxiao
J
Li
Huanfeng
H
Jiang
D000480:Alkynes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
D000480:Alkynes; D000498:Allyl Compounds; D000588:Amines; D011758:Pyrroles; D010165:Palladium; D001966:Bromine