Epicardial adipose tissue is related to coronary collateral vessel formation in patients with acute coronary syndrome.
OBJECTIVE
Epicardial adipose tissue (EAT) is the ectopic fat surrounding the heart, and it may contribute to coronary collateral vessel (CCV) formation. We aimed to evaluate the association of EAT with the presence of CCV in patients with acute coronary syndrome (ACS).


METHODS
A total of 230 patients with ACS were included. The CCVs were graded according to the Rentrop scoring system, and a Rentrop grade 0-1 was accepted as low-grade CCV group, Rentrop grade 2-3 was accepted as high-grade CCV group.


RESULTS
According to angiography, 70 (30%) patients constituted the high-grade CCV group and 160 (70%) constituted the low-grade CCV group. The high-grade CCV group had thicker EAT than the low-grade CCV group (6.1 ± 1.4 vs. 5.3 ± 1.4 mm; p = 0.001). Multivariate logistic regression analysis showed that presence of CCV was independently associated with EAT thickness, ejection fraction, presenting with ST-segment elevation myocardial infarction, and presence of angina on admission. EAT thickness of > 5.7 mm can independently predict high-grade CCV with 73% sensitivity and 69% specificity (area under the curve or AUC: 0.65; 95% confidence interval or CI: 0.57-0.72).


CONCLUSIONS
EAT thickness on admission was associated with the presence of CCVs in patients with ACS.
Cardiology clinic, Turkey Yuksek Ihtisas Education and Research Hospital , Sihhiye, Ankara , Turkey.
Fatih
F
Sen
Samet
S
Yilmaz
Ömer
Ö
Sen
Kevser Gülcihan
KG
Balc
İlker
İ
Duman
Serkan
S
Topaloglu
Ahmet
A
Temizhan
Dursun
D
Aras
D054058:Acute Coronary Syndrome / Q000473:pathology / Q000503:physiopathology; D000273:Adipose Tissue / Q000473:pathology*; D000368:Aged; D003097:Collateral Circulation; D017023:Coronary Angiography / Q000379:methods; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology; D004452:Echocardiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010496:Pericardium / Q000473:pathology*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
acute coronary syndrome; coronary collateral vessel; epicardial adipose tissue thickness