Animal models in HIV-1 protection and therapy.
OBJECTIVE
The purpose of this review is to highlight major advances in the development and use of animal models for HIV-1 research during the last year.


RESULTS
Animal model research during the last year has focused on the development and refinement of models; use of these models to explore key questions about HIV entry, immune control, and persistence; and key discoveries with these models testing therapeutic and vaccine concepts. Some of the greatest breakthroughs have been in understanding early events surrounding transmission, the effectiveness of broadly neutralizing human monoclonal antibodies as passive prophylaxis, and some new ideas in the area of eliminating the viral reservoir in established infection.


CONCLUSIONS
Despite the lack of a flawless HIV-1 infection and pathogenesis model, the field utilizes several models that have already made important contributions to our understanding of early events, immune control, and the potential for novel therapies.
Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Ann J
AJ
Hessell
Nancy L
NL
Haigwood
D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D015483:HIV Antibodies; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control; D015497:HIV-1; D006801:Humans; D008251:Macaca; D051379:Mice; D016097:Simian Acquired Immunodeficiency Syndrome; D015302:Simian Immunodeficiency Virus
D019380:Anti-HIV Agents; D015483:HIV Antibodies