[Glucose homeostasis and gut-brain connection].
Since the XIX(th) century, the brain has been known for its role in regulating food intake (via the control of hunger sensation) and glucose homeostasis. Further interest has come from the discovery of gut hormones, which established a clear link between the gut and the brain in regulating glucose and energy homeostasis. The brain has two particular structures, the hypothalamus and the brainstem, which are sensitive to information coming either from peripheral organs or from the gut (via circulating hormones or nutrients) about the nutritional status of the organism. However, the efforts for a better understanding of these mechanisms have allowed to unveil a new gut-brain neural axis as a key regulator of the metabolic status of the organism. Certain nutrients control the hypothalamic homeostatic function via this axis. In this review, we describe how the gut is connected to the brain via different neural pathways, and how the interplay between these two organs drives the energy balance.
Inserm U855, 7-11 rue Paradin, 69372 Lyon Cedex 08, France ; Université de Lyon, 69008 Lyon, France ; Université Lyon 1, 69622 Villeurbanne, France.
Filipe
F
De Vadder
Inserm U855, 7-11 rue Paradin, 69372 Lyon Cedex 08, France ; Université de Lyon, 69008 Lyon, France ; Université Lyon 1, 69622 Villeurbanne, France.
Gilles
G
Mithieux
D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D017776:Autonomic Pathways / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D005768:Gastrointestinal Hormones / Q000502:physiology; D005943:Gluconeogenesis / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D006815:Hunger / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology; D007422:Intestines / Q000294:innervation / Q000382:microbiology / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D064307:Microbiota; D012528:Satiety Response / Q000502:physiology
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D005947:Glucose