Functional capacity, physical activity, and quality of life in hypoxemic patients with chronic obstructive pulmonary disease.
BACKGROUND
The risk of hypoxemia increases with the progression of chronic obstructive pulmonary disease (COPD) and the deterioration of pulmonary function. The aim of this study was to compare functional capacity, physical activity, and quality of life in hypoxemic and non-hypoxemic patients with COPD.


METHODS
Thirty-nine COPD patients (mean age: 62.0±7.03 years) were included in this study. Arterial blood gas tensions were measured, and patients were divided into two groups according to oxygen partial pressure (PaO2), the hypoxemic COPD (PaO2 <60 mmHg) (n=18), and the control (PaO2 ≥60 mmHg) (n=21) groups. Functional exercise capacity was evaluated using the 6-minute walk test (6MWT). Oxygen saturation, dyspnea, and fatigue perception were measured before and after the 6MWT. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) and an accelerometer. Quality of life was assessed using the St George's Respiratory Questionnaire (SGRQ).


RESULTS
The number of emergency visits and hospitalizations were higher in hypoxemic patients (P<0.05). Lung function parameters, 6MWT distance, exercise oxygen saturation, IPAQ total score, and energy expenditure during daily life were significantly lower, but percentage of maximum heart rate reached during the 6MWT was significantly higher, in hypoxemic COPD patients than in controls (P<0.05).


CONCLUSIONS
Hypoxemia has a profound effect on functional capacity and physical activity in patients with COPD.
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Melda
M
Saglam
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Naciye
N
Vardar-Yagli
School of Physiotherapy and Rehabilitation, Dokuz Eylul University, Izmir, Turkey.
Sema
S
Savci
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Deniz
D
Inal-Ince
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Ebru
E
Calik-Kutukcu
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
Hülya
H
Arikan
Department of Chest Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Lutfi
L
Coplu
D000328:Adult; D000368:Aged; D017281:Cost of Illness; D003430:Cross-Sectional Studies; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D005541:Forced Expiratory Volume; D006304:Health Status; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D011237:Predictive Value of Tests; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D011788:Quality of Life; D011795:Surveys and Questionnaires
6-minute walk test; COPD; hypoxemia