[A case of AFP-producing esophagogastric junction cancer with liver metastases with a good response to chemotherapy].
A 62-year-old man was diagnosed with esophagogastric junction cancer following esophagogastroduodenoscopy in response to hematemesis. Although liver metastasis was detected during surgery, a total gastrectomy and lower esophagus resection for local control was performed. Alpha-fetoprotein(AFP)-producing tumor with hepatoid adenocarcinoma was diagnosed on the basis of the pathological examination. Serum AFP levels remained high postoperatively and multiple liver metastases were detected on computed tomography imaging. After 6 courses of chemotherapy with S-1 and cisplatin (CDDP), a significant reduction in the size of the liver metastases and a decrease of serum AFP levels were achieved. Postoperative 2-year tumor control using S-1 single agent chemotherapy was obtained. AFP-producing esophagogastric junction cancer has a poor prognosis. This case raises the possibility that long-term survival can be obtained by combining surgery for local control with systemic chemotherapy.
Dept. of Surgery, Hiroshima City Hiroshima Citizens Hospital.
Yasuo
Y
Nagai
Takuya
T
Kato
Masao
M
Harano
Daisuke
D
Satoh
Yasuhiro
Y
Choda
Noriaki
N
Tokumoto
Takashi
T
Kanazawa
Hiroyoshi
H
Matsukawa
Yasutomo
Y
Ojima
Hitoshi
H
Idani
Shigehiro
S
Shiozaki
Masazumi
M
Okajima
Motoki
M
Ninomiya
Satoshi
S
Ohno
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D004943:Esophagogastric Junction / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000096:biosynthesis
D004338:Drug Combinations; D000509:alpha-Fetoproteins; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin