Head and neck solitary infantile myofibroma: Clinicopathological and immunohistochemical features of a case series.
Infantile myofibroma is a rare mesenchymal benign tumor mostly found in the head and neck region. The aim of this study was to describe a small case series of head and neck solitary infantile myofibroma, emphasizing the importance of the histopathological and immunohistochemical features, and the potential diagnostic challenges. For the study, clinical and imaging data were obtained from the medical records. All cases were histologically reviewed, and immunohistochemical analyses were performed to confirm the diagnosis. Four cases of head and neck solitary infantile myofibroma were identified. All patients were females and presented a mean age of 3 years old (ranging from 2 to 6 years). The site of the tumors were the mandible, right cheek, subcutaneous tissue adjacent to basal cortical of the mandible and upper anterior gingiva. No symptoms, such as pain or paresthesia, were reported. Computerized tomography revealed well-delimited tumors. All tumors were positive for vimentin and alpha-smooth muscle actin. All patients underwent surgical excision and no signs of recurrence were observed after long-term follow-up. In summary, head and neck solitary infantile myofibromas are rare and present excellent prognosis. The correlation between clinical, histopathological and immunohistochemical features are essential for a correct diagnosis.
Department of Stomatology, A. C. Camargo Cancer Center, São Paulo, São Paulo, Brazil.
Rodrigo Nascimento
RN
Lopes
Department of Stomatology, A. C. Camargo Cancer Center, São Paulo, São Paulo, Brazil.
Fábio de Abreu
Fde A
Alves
Department of Stomatology, A. C. Camargo Cancer Center, São Paulo, São Paulo, Brazil.
André Caroli
AC
Rocha
Department of Oral and Maxillofacial Surgery, Hospital Geral de Areias, Recife, Pernambuco, Brazil.
Thales M
TM
Suassuna
Department of Head and Neck Surgery and Otorhinolaryngology, A. C. Camargo Cancer Center, São Paulo, São Paulo, Brazil.
Luiz Paulo
LP
Kowalski
School of Dentistry, Oral Pathology Section, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Jurema Freire Lisboa
JF
de Castro
School of Dentistry, Oral Pathology Section, Federal University of Pernambuco, Recife, Pernambuco, Brazil. Electronic address: danyel.perez@ufpe.br.
Danyel Elias da Cruz
DE
Perez
D000199:Actins / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D047708:Myofibroma / Q000000981:diagnostic imaging / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000096:biosynthesis*
D000199:Actins; D009363:Neoplasm Proteins; D014746:Vimentin
Differential diagnosis; Head and neck; Immunohistochemistry; Infantile myofibroma; Mandible