Feeding the human brain model.
The goal of the Human Brain Project is to develop, during the next decade, an infrastructure capable of simulating a draft human brain model based on available experimental data. One of the key issues is therefore to integrate and make accessible the experimental data necessary to constrain and fully specify this model. The required data covers many different spatial scales, ranging from the molecular scale to the whole brain and these data are obtained using a variety of techniques whose measurements may not be directly comparable. Furthermore, these data are incomplete, and will remain so at least for the coming decade. Here we review new neuroinformatics techniques that need to be developed and applied to address these issues.
Donders Institute, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. Electronic address: p.tiesinga@science.ru.nl.
Paul
P
Tiesinga
Donders Institute, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands; Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6), Jülich Research Centre and JARA, 52425 Jülich, Germany.
Rembrandt
R
Bakker
Blue Brain Project, Campus Biotech, Bâtiment B1, Ch. Des Mines 9, Geneva CH-1202, Switzerland.
Sean
S
Hill
Institute of Basic Medical Sciences, University of Oslo, PO Box 1105, Blindern, N-0317 Oslo, Norway.
Jan G
JG
Bjaalie
D064229:Biological Ontologies / Q000458:organization & administration*; D001921:Brain / Q000502:physiology*; D019295:Computational Biology / Q000458:organization & administration*; D006801:Humans; D008962:Models, Theoretical; D009488:Neurosciences / Q000458:organization & administration*