A case of endobronchial NUT midline carcinoma with intraluminal growth.
BACKGROUND
NUT midline carcinoma (NMC) is a rare, lethal form of differentiated squamous cell carcinoma characterized by chromosomal rearrangement of the NUT gene. Its highly aggressive nature commonly leads to unresectable and metastatic lesions.


METHODS
We report on a case of endobronchial NMC in a middle-aged man who was treated by bronchoscopic electrocautery followed by Ewing sarcoma-based chemotherapy with concurrent chemoradiotherapy. The patient's disease continued to be stable 31 months after diagnosis.


METHODS
NMC is a challenging disease entity, which is difficult to diagnose and treat, and has a dismal overall survival. Most cases of NMC are widely metastatic or unresectable when diagnosed.


CONCLUSIONS
This is the first reported case that involves intraluminal tumour growth of NMC and demonstrates the effectiveness of early intensive local therapy aided by bronchoscopic techniques.
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan sh.watanabe02@gmail.com.
Sho
S
Watanabe
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Satoshi
S
Hirano
Department of Pathology, National Center for Global Health and Medicine, Tokyo, Japan.
Sohtaro
S
Mine
Department of Pathology, National Cancer Center Hospital, Tokyo, Japan.
Akihiko
A
Yoshida
Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Toru
T
Motoi
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Satoshi
S
Ishii
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Go
G
Naka
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Yuichiro
Y
Takeda
Department of Pathology, National Center for Global Health and Medicine, Tokyo, Japan.
Toru
T
Igari
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Haruhito
H
Sugiyama
Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan.
Nobuyuki
N
Kobayashi
D001984:Bronchial Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D014057:Tomography, X-Ray Computed
C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins
Ewing sarcoma; NUT midline carcinoma; Nuclear protein in testis; electrocautery; endobronchial tumour