Diagnostic value of contrast-enhanced ultrasound in thyroid nodules with calcification.
The aim of this study was to investigate the diagnostic values of conventional ultrasound and contrast-enhanced ultrasound (CEUS) in benign and malignant thyroid nodules with calcification. Conventional ultrasound and CEUS were performed in 122 patients with thyroid nodules with calcification. The thyroid nodules were characterized as benign or malignant by pathological diagnosis. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accordance rate of the two imaging methods were determined. The area under the receiver operating characteristics curve (AUC) was used to assess the diagnostic values of the two imaging methods. In 122 cases of thyroid nodules with calcification, 73 benign nodules and 49 malignant nodules were verified by pathological diagnosis. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accordance rate of conventional ultrasound were 50%, 77%, 59%, 69%, and 66%, respectively, and those of CEUS were 90%, 92%, 88%, 93%, and 91%, respectively. There were significant differences between the two imaging methods. AUCs of conventional ultrasound and CEUS were 0.628 ± 0.052 and 0.908 ± 0.031, suggesting low and high diagnostic values, respectively. CEUS has high diagnostic values, being significantly greater than those of conventional ultrasound, in differential diagnosis of benign and malignant thyroid nodules with calcification.
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China.
Jue
J
Jiang
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China.
Xu
X
Shang
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China.
Hua
H
Wang
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China.
Yong-Bo
YB
Xu
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China. Electronic address: yagaocn@126.com.
Ya
Y
Gao
Department of Medical Ultrasound, The 2nd Affiliated Hospital, Xi'an JiaoTong University School of Medicine, Xi'an, Shanxi Province, China. Electronic address: qizhoucn@163.com.
Qi
Q
Zhou
D000236:Adenoma / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006044:Goiter, Nodular / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D012372:ROC Curve; D013459:Sulfur Hexafluoride; D016606:Thyroid Nodule / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
Calcification; Contrast-enhanced ultrasound; ROC curve; Thyroid nodules