Synthesis, antioxidant and anti-microbial properties of two organoselenium compounds.
The aim of this study is synthesis of two different series of organoselenium compounds and available in vitro antioxidant and antimicrobial properties of these synthetic compounds. The synthetic compounds were identified by (1)H-NMR (300 MHz), (13)C-NMR (75.5 MHz), FT-IR spectroscopic techniques and micro analysis. Antioxidant properties of two synthetic organoselenium compounds were determined by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical method, reducing power assay and β-carotene bleaching method as in vitro. Antimicrobial effects of samples were assessed by the agar dilution procedure and using gram positive and gram-negative bacteria and yeast strains. Although 1,3-di-p-methoxybenzylpyrimidine-2-selenone showed better antiradical activity in DPPH test and higher protective activity on β-carotene, 1-isopropyl-3-methylbenzimidazole-2-selenone was found to be better in reducing power and antimicrobial activity.
Department of Biology, Faculty of Arts and Science, Nigde University, Nigde, Turkey.
Zeliha Selamoglu
ZS
Talas
Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey.
Yetkin
Y
Gok
Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey.
Ilknur
I
Ozdemir
Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey.
Burhan
B
Ates
Department of Microbiology, Faculty of Medicine, Inonu University, Malatya, Turkey.
Selami
S
Gunal
Department of Chemistry, Faculty of Arts and Sciences, Inonu University, Malatya, Turkey.
Ismet
I
Yilmaz
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000890:Anti-Infective Agents; D000975:Antioxidants; D016566:Organoselenium Compounds