A protease inhibition strategy based on acceleration of autolysis.
We report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. We show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. This new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
Laboratory of Biomedical Materials Engineering, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, P. R. China. maxj@dicp.ac.cn lgj1802@dicp.ac.cn.
Yan
Y
Lv
Jianbin
J
Zhang
Hao
H
Wu
Shan
S
Zhao
Yizhe
Y
Song
Shujun
S
Wang
Bing
B
Wang
Guojun
G
Lv
Xiaojun
X
Ma
D000180:Acrylic Resins / Q000737:chemistry; D000464:Alginates / Q000737:chemistry; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002417:Cattle; D016264:Dextran Sulfate / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006207:Half-Life; D006493:Heparin / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007700:Kinetics; D010179:Pancreas / Q000737:chemistry / Q000201:enzymology; D011480:Protease Inhibitors / Q000737:chemistry*; D059748:Proteolysis; D012996:Solutions; D014357:Trypsin / Q000737:chemistry* / Q000302:isolation & purification
D000180:Acrylic Resins; D000464:Alginates; D006603:Hexuronic Acids; D011480:Protease Inhibitors; D012996:Solutions; C006903:carbopol 940; D020723:Glucuronic Acid; D006493:Heparin; D016264:Dextran Sulfate; D014357:Trypsin; D002266:Carboxymethylcellulose Sodium