Efficacy of random-start controlled ovarian stimulation in cancer patients.
This study aimed to evaluate the efficacy of random-start controlled ovarian stimulation (COS) in cancer patients for emergency fertility preservation. In this retrospective comparative study, 22 patients diagnosed with cancer and 44 infertile women undergoing conventional in vitro fertilization (IVF) were included. In cancer patients, ovarian stimulation was started on the day of referral, irrespective of their menstrual cycle date. The control group was selected by age matching among women undergoing conventional IVF. COS outcomes were compared between groups. The number of total and mature oocytes retrieved and the oocyte maturity rate were higher in the random-start group than in the conventional-start group. However, duration of ovarian stimulation was longer in the random-start group (11.4 vs. 10.3 days, P = 0.004). The addition of letrozole to lower the estradiol level during COS did not adversely affect total oocytes retrieved. However, oocyte maturity rate was lower in cycles with letrozole than in cycles without letrozole (71.6% vs. 58.2%, P = 0.019). Our study confirms the feasibility and effectiveness of random-start COS in cancer patients.
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
Jee Hyun
0000-0003-1336-3620
JH
Kim
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Seul Ki
0000-0002-1647-6711
SK
Kim
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Hee Jun
0000-0002-3478-7046
HJ
Lee
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Jung Ryeol
0000-0003-3743-2934
JR
Lee
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Byung Chul
0000-0003-2289-6090
BC
Jee
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Chang Suk
0000-0003-1835-7350
CS
Suh
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Seok Hyun
0000-0003-0649-3224
SH
Kim
D015925:Cryopreservation; D004958:Estradiol / Q000097:blood; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000601:surgery; D000077289:Letrozole; D009369:Neoplasms; D009570:Nitriles / Q000627:therapeutic use; D054315:Oocyte Retrieval / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D012189:Retrospective Studies; D014230:Triazoles / Q000627:therapeutic use
D009570:Nitriles; D014230:Triazoles; D004958:Estradiol; D000077289:Letrozole
Cancer; Controlled Ovarian Stimulation; Emergency; Fertility Preservation; In Vitro Fertilization Outcomes; Random-start