Human T lymphotropic virus type-1-associated myelopathy manifesting shortly after living-donor renal transplantation.
A 38-year-old woman experienced numbness in both lower extremities and spastic paralysis a few months after undergoing living-donor renal transplantation. The patient was negative for human T lymphotropic virus type-1 (HTLV-1) antibodies prior to the procedure; however, she was diagnosed with HTLV-1-associated myelopathy (HAM) based on positive serum and cerebrospinal fluid antibody titers after the surgery. Because the donor was also positive for HTLV-1 antibodies, the infection likely originated from the transplanted kidney. Clinical and imaging improvements were noted following the administration of interferon-α. HAM has been reported to occur after living-donor renal transplantation; however, there are no previous reports of onset within such a short period.
Department of Neurology, Saitama Medical University International Medical Center, Japan.
Yuito
Y
Nagamine
Takeshi
T
Hayashi
Yuji
Y
Kato
Yohsuke
Y
Horiuchi
Norio
N
Tanahashi
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D015368:Human T-lymphotropic virus 1 / Q000472:pathogenicity*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D019520:Living Donors; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*; D016896:Treatment Outcome
D000998:Antiviral Agents; D016898:Interferon-alpha