i-Motifs are more stable than G-quadruplexes in a hydrated ionic liquid.
Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution.
Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamachi, Kobe 650-0047, Japan.
Hisae
H
Tateishi-Karimata
Miki
M
Nakano
Smritimoy
S
Pramanik
Shigenori
S
Tanaka
Naoki
N
Sugimoto
D054856:G-Quadruplexes / Q000187:drug effects*; D052578:Ionic Liquids / Q000737:chemistry* / Q000494:pharmacology*; D056004:Molecular Dynamics Simulation; D059372:Nucleotide Motifs / Q000187:drug effects*; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
D052578:Ionic Liquids; D014867:Water