[Perioperative primary thrombosis prophylaxis for colorectal cancer in an asymptomatic antiphospholipid antibody carrier -a case report and literature review-].
An 82-year-old woman presented with hematochezia and was diagnosed with resectable colon cancer. Laboratory analysis revealed prolonged activated partial thromboplastin time and false-positive reactions in serological tests for syphilis; results that were subsequently found to be caused by the presence of antiphospholipid antibody. Because she had no history of thrombotic events or pregnancy morbidity, she was considered to be an asymptomatic antiphospholipid antibody carrier (aaPL carrier). Throughout the perioperative period, anticoagulation was performed without complications, including thrombosis. aaPL carriers are not uncommon in clinical practice, and the attending gastroenterologist should assess the risk of future thrombotic events and the most effective means of preventing thrombosis. However, there are few evidence-based recommendations for primary thrombosis prevention in aaPL carriers over the long-term and in high-risk periods, such as the perioperative period. Here, we discuss aaPL carrier management with a focus on the perioperative period together with a review of the literature.
Department of Gastroenterology, Otaru General Hospital.
Takashi
T
Yabana
Akira
A
Goto
Motohisa
M
Yamamoto
Yu
Y
Ishimine
Hidenori
H
Yajima
Suguru
S
Nakagaki
Takeya
T
Adachi
Yoshihiro
Y
Kondo
D000230:Adenocarcinoma / Q000601:surgery*; D000368:Aged; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000276:immunology; D000925:Anticoagulants / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D059035:Perioperative Period; D011322:Primary Prevention; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery*; D013927:Thrombosis / Q000517:prevention & control*
D017152:Antibodies, Antiphospholipid; D000925:Anticoagulants