De novo Crohn's disease following orthotopic liver transplantation: a case report and literature review.
The development of de novo Crohn's disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.
Division of Gastroenterology, Tohoku University Graduate School of Medicine, Japan.
Takeo
T
Naito
Hisashi
H
Shiga
Katsuya
K
Endo
Masatake
M
Kuroha
Yoichi
Y
Kakuta
Yoshitaka
Y
Kinouchi
Tooru
T
Shimosegawa
D001656:Biliary Atresia / Q000601:surgery; D003082:Colectomy; D003424:Crohn Disease / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007564:Japan; D016031:Liver Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications / Q000601:surgery*; D055815:Young Adult