Recent advances in neuroimaging to model eating disorder neurobiology.
The eating disorders (EDs) anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED) are severe psychiatric disorders with high mortality. There are many symptoms, such as food restriction, episodic binge eating, purging, or excessive exercise that are either overlapping or lie on opposite ends of a scale or spectrum across those disorders. Identifying how specific ED behaviors are linked to particular neurobiological mechanisms could help better categorize ED subgroups and develop specific treatments. This review provides support from recent brain imaging research that brain structure and function measures can be linked to disorder-specific biological or behavioral variables, which may help distinguish ED subgroups, or find commonalities between them. Brain structure and function may therefore be suitable research targets to further study the relationship between dimensions of behavior and brain function relevant to EDs and beyond the categorical AN, BN, and BED distinctions.
Departments of Psychiatry and Neuroscience, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Gary Pavilion A036/B-130, 13123 East 16th Avenue, Aurora, CO, 80045, USA, Guido.Frank@ucdenver.edu.
Guido K W
GK
Frank
D000856:Anorexia Nervosa / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D056912:Binge-Eating Disorder / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002032:Bulimia / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D052018:Bulimia Nervosa / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001068:Feeding and Eating Disorders; D006801:Humans; D009446:Neurobiology; D059906:Neuroimaging