Trends in management and outcomes of ST-elevation myocardial infarction in patients with end-stage renal disease in the United States.
Acute myocardial infarction in patients with end-stage renal disease (ESRD) is associated with increased risk of morbidity and mortality. Limited data are available on the contemporary trends in management and outcomes of ST-elevation myocardial infarction (STEMI) in patients with ESRD. We analyzed the 2003 to 2011 Nationwide Inpatient Sample databases to examine the temporal trends in STEMI, use of mechanical revascularization for STEMI, and in-hospital outcomes in patients with ESRD aged ≥18 years in the United States. From 2003 to 2011, whereas the number of patients with ESRD admitted with the primary diagnosis of acute myocardial infarction increased from 13,322 to 20,552, there was a decrease in the number of STEMI hospitalizations from 3,169 to 2,558 (ptrend <0.001). The overall incidence rate of cardiogenic shock in patients with ESRD and STEMI increased from 6.6% to 18.3% (ptrend <0.001). The use of percutaneous coronary intervention for STEMI increased from 18.6% to 37.8% (ptrend <0.001), whereas there was no significant change in the use of coronary artery bypass grafting (ptrend = 0.32). During the study period, in-hospital mortality increased from 22.3% to 25.3% (adjusted odds ratio [per year] 1.09; 95% confidence interval 1.08 to 1.11; ptrend <0.001). The average hospital charges increased from $60,410 to $97,794 (ptrend <0.001), whereas the average length of stay decreased from 8.2 to 6.5 days (ptrend <0.001). In conclusion, although there have been favorable trends in the utilization of percutaneous coronary intervention and length of stay in patients with ESRD and STEMI, the incidence of cardiogenic shock has increased threefold, with an increase in risk-adjusted in-hospital mortality, likely because of the presence of greater co-morbidities.
Department of Medicine, New York Medical College, Valhalla, New York.
Tanush
T
Gupta
Department of Medicine, New York Medical College, Valhalla, New York.
Prakash
P
Harikrishnan
Department of Medicine, New York Medical College, Valhalla, New York.
Dhaval
D
Kolte
Division of Cardiology, New York Medical College, Valhalla, New York.
Sahil
S
Khera
Division of Cardiology, New York Medical College, Valhalla, New York.
Kathir S
KS
Subramanian
Department of Medicine, New York Medical College, Valhalla, New York.
Marjan
M
Mujib
Division of Cardiology, New York Medical College, Valhalla, New York.
Ali
A
Masud
Department of Medicine, Mount Sinai Medical Center, New York, New York.
Chandrasekar
C
Palaniswamy
Department of Medicine, New York Medical College, Valhalla, New York.
Sachin
S
Sule
Division of Cardiology, New York Medical College, Valhalla, New York.
Diwakar
D
Jain
Department of Medicine, Veterans Affairs Medical Center, Washington, District of Columbia.
Ali
A
Ahmed
Division of Cardiology, New York Medical College, Valhalla, New York.
Gregg M
GM
Lanier
Division of Cardiology, New York Medical College, Valhalla, New York.
Howard A
HA
Cooper
Division of Cardiology, New York Medical College, Valhalla, New York.
William H
WH
Frishman
Heart and Vascular Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Deepak L
DL
Bhatt
David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California.
Gregg C
GC
Fonarow
Division of Cardiology, New York Medical College, Valhalla, New York.
Julio A
JA
Panza
Division of Cardiology, New York Medical College, Valhalla, New York. Electronic address: wsaronow@aol.com.
Wilbert S
WS
Aronow
D000368:Aged; D015897:Comorbidity; D019468:Disease Management; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D017721:Hospital Costs / Q000639:trends; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000191:economics / Q000453:epidemiology*; D007902:Length of Stay / Q000639:trends; D008297:Male; D009203:Myocardial Infarction / Q000191:economics / Q000453:epidemiology* / Q000601:surgery; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology