Takotsubo cardiomyopathy with involvement of delayed-onset rhabdomyolysis and acute kidney injury after rosuvastatin treatment.
Takotsubo cardiomyopathy is a disorder characterized by left ventricular apical ballooning with preceding emotional and/or physical stressors. This condition is also an important differential diagnosis of acute coronary syndrome. We herein describe a case of Takotsubo cardiomyopathy, a significant clinical phenomenon, triggered by delayed-onset rhabdomyolysis following the administration of long-term statin treatment, without any preceding stressors or changes in the patient's medical condition, in association with complaints of non-specific muscle-related symptoms. Although an electrocardiogram showed remarkable ST-segment elevation, a careful reading of the electrocardiogram findings revealed the features of Takotsubo cardiomyopathy. Withdrawing the statin therapy improved the patient's cardiac function.
Division of Cardiology, Fujita Health University Second Hospital, Japan.
Tomohito
T
Kamada
Mutsuharu
M
Hayashi
Hiroatsu
H
Yokoi
Wakaya
W
Fujiwara
Daiji
D
Yoshikawa
Daisuke
D
Mukaide
Yoshinori
Y
Sugishita
Masataka
M
Yoshinaga
Takehiro
T
Ito
Yukio
Y
Ozaki
Hideo
H
Izawa
D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000473:pathology; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005464:Fluorobenzenes / Q000009:adverse effects*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D011743:Pyrimidines / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000009:adverse effects*; D054549:Takotsubo Cardiomyopathy / Q000139:chemically induced* / Q000175:diagnosis; D016896:Treatment Outcome; D028761:Withholding Treatment
D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium