Gastric inflammatory fibroid polyp morphologically changed by Helicobacter pylori eradication.
A 60-year-old male presented to our hospital for further investigation of abnormal findings on an upper gastrointestinal series. Esophagogastroduodenoscopy demonstrated atrophic gastritis and a submucosal tumor (SMT) at the anterior wall of the antrum. The patient was positive for serum anti-Helicobacter pylori (H. pylori) antibody and H. pylori eradication therapy was performed. Five months later, the SMT showed a remarkable morphological change in that an ulcer had developed on its apex, and partial gastrectomy was performed. Pathological examination suggested an inflammatory fibroid polyp (IFP), and genetic analysis revealed no mutation in the platelet-derived growth factor receptor alpha gene. This case suggests that H. pylori infection plays an important role in the etiology of IFPs.
Department of Gastroenterology, National Hospital Organization Kochi National Hospital, Kochi, Japan, ymitsui.med@gmail.com.
Yasuhiro
Y
Mitsui
Kaizo
K
Kagemoto
Tatsuzo
T
Itagaki
Shuji
S
Inoue
Keishi
K
Naruse
Naoki
N
Muguruma
Tetsuji
T
Takayama
D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use; D016145:Endoscopy, Digestive System; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000150:complications / Q000473:pathology* / Q000601:surgery; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D064750:Rabeprazole / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D064750:Rabeprazole; D000658:Amoxicillin; D017291:Clarithromycin