Thyroxine-induced metamorphosis in the axolotl (Ambystoma mexicanum).
The axolotl (Ambystoma mexicanum) has remained an important model for regeneration and developmental biology for over a century. Although axolotls in captive-bred colonies usually exist in an aquatic form, they retain the ability to undergo metamorphosis following exposure to thyroid hormone. Here we present a robust method for inducing metamorphosis in adult axolotls that results in high survivability and produces terrestrial animals that can be maintained in long-term captivity.
Department of Biology, University of Kentucky, 101 T.H. Morgan Building, Lexington, KY, 40506-0225, USA.
Peggy S
PS
Coots
Ashley W
AW
Seifert
D000558:Ambystoma mexicanum / Q000254:growth & development*; D000818:Animals; D008675:Metamorphosis, Biological / Q000187:drug effects*; D016019:Survival Analysis; D013974:Thyroxine / Q000494:pharmacology*
D013974:Thyroxine