Metabolic remodeling: a pyruvate transport affair.
Metabolic remodeling is a major determinant for many cell fate decisions, and a switch from respiration to aerobic glycolysis is generally considered as a hallmark of cancer cell transformation. Pyruvate is a key metabolite at the major junction of carbohydrate metabolism between cytosolic glycolysis and the mitochondrial Krebs cycle. In this issue of The EMBO Journal, Bender et al show that yeast cells regulate pyruvate uptake into mitochondria, and thus its metabolic fate, by expressing alternative pyruvate carrier complexes with different activities.
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany.
Heike
H
Rampelt
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Freiburg, Germany BIOSS Centre for Biological Signalling Studies, Universität Freiburg, Freiburg, Germany.
Martin
M
van der Laan
D027321:Anion Transport Proteins / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000096:biosynthesis*; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000096:biosynthesis*; D019289:Pyruvic Acid / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis*
D027321:Anion Transport Proteins; C573717:FMP43 protein, S cerevisiae; C573716:MPC2 protein, S cerevisiae; D008565:Membrane Proteins; D033681:Mitochondrial Membrane Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D019289:Pyruvic Acid; C413542:GPI13 protein, S cerevisiae; D017853:Phosphotransferases (Alcohol Group Acceptor)