Anti-mutagenic activity of Salvia merjamie extract against gemcitabine.
Gemcitabine is an anti-cancer drug with clinically uses in the treatment of various neoplasms, including breast, ovarian, non-small cell lung, pancreaticand cervical cancers, T-cell malignancies, germ cell tumours, and hepatocellular carcinomas. However, it has also been reported to have many adverse effects. Naturally occurring anti-mutagenic effects, especially those of plant origin, have recently become a subject of intensive research. The present study was therefore designed to investigate the anti-mutagenic effects of Salvia merjamie (Family: Lamiaceae) plant extracts against the mutagenic effects of gemcitabine. The anti-mutagenic properties of Salvia merjamie were tested in Inbred SWR/J male and female mice bone marrow cells. The mice were treated in four groups; a control group treated with 30 mg/kg body weight gemcitabine and three treatment groups, each with 30 mg/kg body weight gemcitabine together with, respectively, 50, 100 and 150 mg/kg body weight Salvia merjamie extract. Chromosomal aberration and mitotic index assays were performed with the results demonstrating that Salvia merjamie extract protects bone marrow cells in mice against gemcitabine induced mutagenicity. This information can be used for the development of a potential therapeutic anti-mutagenic agents.
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia E-mail : kalanzi@ksu.edu.sa, mrkhaledonly@yahoo.com.
Khalid Mashay
KM
Alanazi
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001892:Camphanes; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D008940:Mitotic Index; D053723:Panax notoginseng; D027561:Salvia miltiorrhiza; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D016587:Antimutagenic Agents; D001892:Camphanes; D004365:Drugs, Chinese Herbal; C000604051:danshen dripping pill; D003841:Deoxycytidine; D000093542:Gemcitabine