Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.
Chemoenzymatic dynamic kinetic resolution (DKR) constitutes a convenient and efficient method to access enantiomerically pure alcohol and amine derivatives. This Perspective highlights the work carried out within this field during the past two decades and pinpoints important avenues for future research. First, the Perspective will summarize the more developed area of alcohol DKR, by delineating the way from the earliest proof-of-concept protocols to the current state-of-the-art systems that allows for the highly efficient and selective preparation of a wide range of enantiomerically pure alcohol derivatives. Thereafter, the Perspective will focus on the more challenging DKR of amines, by presenting the currently available homogeneous and heterogeneous methods and their respective limitations. In these two parts, significant attention will be dedicated to the design of efficient racemization methods as an important means of developing milder DKR protocols. In the final part of the Perspective, a brief overview of the research that has been devoted toward improving enzymes as biocatalysts is presented.
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden.
Oscar
O
Verho
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden.
Jan-E
JE
Bäckvall
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D001419:Bacteria / Q000201:enzymology*; D055162:Biocatalysis; D002384:Catalysis; D005658:Fungi / Q000201:enzymology*; D007218:Industrial Microbiology; D007700:Kinetics; D008049:Lipase / Q000378:metabolism; D008670:Metals / Q000737:chemistry; D008958:Models, Molecular; D013237:Stereoisomerism
D000438:Alcohols; D000588:Amines; D008670:Metals; D008049:Lipase