Dextrin-based nanomagnetogel: in vivo biodistribution and stability.
The biodistribution profile of a new dextrin nanomagnetogel, which consists of γ-Fe2O3 superparamagnetic nanoparticles loaded within a polymeric matrix of modified dextrin, was studied in mice. The nanomagnetogel bear a monomodal size distribution profile (average diameter 110 nm) close to neutral surface charge and higher relaxivity (r2 = 215-248 mM(-1) s(-1) and r2/r1 = 13-11) than those of commercial formulations (r2 = 160-177 mM(-1) s(-1) and r2/r1 = 4-7). Also, the observed blood half-life-approximately 4 h-is superior to that of similar commercially available formulations, which remain for a few minutes in circulation. PEGylation resulted in 1.7- and 1.2-fold lower accumulation in the liver and spleen, respectively, within the first 24 h. Noteworthy, a good correlation was obtained between the amount of polymer (quantified by scintigraphy) in the spleen, 48 h after administration, and the amount of iron physically loaded through hydrophobic interactions (quantified by ICP) indicating the absence of iron leakage from the polymeric matrix. This study provides evidence of the in vivo stability of a self-assembled nanomagnetogel, a relevant feature which is seldom reported in the literature.
C
C
Gonçalves
J P
JP
Silva
‡Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
I F
IF
Antunes
M F M
MF
Ferreira
J A
JA
Martins
⊥Chemistry Department, Faculty of Science and Technology, and Coimbra Chemistry Center, University of Coimbra, 3001-401 Coimbra, Portugal.
C F G C
CF
Geraldes
§CSPBAT Laboratory, UMR 7244 CNRS, Université Paris 13, Sorbonne Paris Cité, 93017 Bobigny, France.
Y
Y
Lalatonne
§CSPBAT Laboratory, UMR 7244 CNRS, Université Paris 13, Sorbonne Paris Cité, 93017 Bobigny, France.
L
L
Motte
‡Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
E F J
EF
de Vries
F M
FM
Gama
D000818:Animals; D003912:Dextrins / Q000737:chemistry / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004355:Drug Stability; D005290:Ferric Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D005782:Gels; D006207:Half-Life; D057927:Hydrophobic and Hydrophilic Interactions; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D011092:Polyethylene Glycols / Q000737:chemistry; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D055672:Static Electricity; D013499:Surface Properties; D015899:Tomography, Emission-Computed, Single-Photon
D003912:Dextrins; D004337:Drug Carriers; D005290:Ferric Compounds; D005782:Gels; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D011092:Polyethylene Glycols