[Haplotype analysis of XRCC3 gene and laryngeal].
OBJECTIVE
To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal.


METHODS
We selected 4 tag SNPs (rs12432907, rs861536, rs861537, rs861531, rs861531) for the present study. 310 laryngeal patients and 310 healthy control subject were genotyping. The distribution of genotypes and haplotypes in these two group was compared.


RESULTS
The distributions of rs12432907 was significantly different between these two groups. The CCAG haplotype frequency was higher in laryngeal group than that in control group. But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject.


CONCLUSIONS
XRCC3 gene polymorphism was associated with the risk of laryngeal patients.
Xu
X
Zhou
Ying
Y
Qi
D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3