[Improvement of the viscosity and the intrahepatic distribution of miriplatin-lipiodol suspension].
The effects of warming or emulsification with the water-soluble contrast medium, Iomeron (IOM), on reducing the viscosity of miriplatin-lipiodol (MPT-LPD) suspension were studied. Reduction in the viscosity of MPT-LPD suspension was ob- served upon increasing the temperature. Although the O/W MPT-LPD emulsion with a low ratio of MPT-LPD to IOM reduced the viscosity, the effect was lesser than that achieved with the warming treatment. Radiographic images of the liver obtained after administration of the emulsion into the rat portal vein showed that warming resulted in improved intrahepatic distribution of the formulation, which was dependent on the reduction of viscosity. Emulsification also led to better intrahepatic distribution, but this distribution did not depend on the viscosity of the formulation. The MPT-LPD emulsion showed different distribution properties from the MPT-LPD suspension, and it was difficult to estimate the intrahepatic distribution property from the viscosity of the emulsion. Thus, we suggest that emulsification and warming of MPT-LPD are effective methods for improving the intrahepatic distribution of the MPT formulation.
Faculty of Pharmaceutical Sciences, Kobe Gakuin University.
Shuichi
S
Kishimoto
Shingo
S
Adachi
Aya
A
Masui
Ryosuke
R
Suzuki
Shoji
S
Fukushima
D000818:Animals; D004655:Emulsions; D004998:Ethiodized Oil / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism*; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013535:Suspensions; D014783:Viscosity
D004655:Emulsions; D009944:Organoplatinum Compounds; D013535:Suspensions; C406530:miriplatin; D004998:Ethiodized Oil