Mesial temporal lobe and memory function in autism spectrum disorder: an exploration of volumetric findings.
Studies have shown that individuals with autism spectrum disorder (ASD) tend to perform significantly below typical developing individuals on standardized measures of memory, even when not significantly different on measures of IQ. The current study sought to examine within ASD whether anatomical correlates of memory performance differed between those with average-to-above-average IQ (AIQ group) and those with low-average to borderline ability (LIQ group) as well as in relations to typically developing comparisons (TDC). Using automated volumetric analyses, we examined regional volume of classic memory areas including the hippocampus, parahippocampal gyrus, entorhinal cortex, and amygdala in an all-male sample AIQ (n = 38) and LIQ (n = 18) individuals with ASD along with 30 typically developing comparisons (TDC). Memory performance was assessed using the Test of Memory and Learning (TOMAL) compared among the groups and then correlated with regional brain volumes. Analyses revealed group differences on almost all facets of memory and learning as assessed by the various subtests of the TOMAL. The three groups did not differ on any region of interest (ROI) memory-related brain volumes. However, significant size-memory function interactions were observed. Negative correlations were found between the volume of the amygdala and composite, verbal, and delayed memory indices for the LIQ ASD group, indicating larger volume related to poorer performance. Implications for general memory functioning and dysfunctional neural connectivity in ASD are discussed.
a Department of Psychology , Brigham Young University , Provo , UT , USA.
Haley G
HG
Trontel
Tyler C
TC
Duffield
Erin D
ED
Bigler
Tracy J
TJ
Abildskov
Alyson
A
Froehlich
Molly B D
MB
Prigge
Brittany G
BG
Travers
Jeffrey S
JS
Anderson
Brandon A
BA
Zielinski
Andrew L
AL
Alexander
Nicholas
N
Lange
Janet E
JE
Lainhart
D000293:Adolescent; D000704:Analysis of Variance; D000067877:Autism Spectrum Disorder / Q000150:complications* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007360:Intelligence; D007858:Learning; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D011939:Mental Recall; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic; D013702:Temporal Lobe / Q000254:growth & development / Q000473:pathology*; D055815:Young Adult
Autism spectrum disorders; Magnetic resonance imaging; Memory; Neurodevelopmental disorders