Protective effects of remote ischemic preconditioning in rat hindlimb on ischemia- reperfusion injury.
Three cycles of remote ischemic pre-conditioning induced by temporarily occluding the bilateral femoral arteries (10 minutes) prior to 10 minutes of reperfusion were given once a day for 3 days before the animal received middle artery occlusion and reperfusion surgery. The results showed that brain infarct volume was significantly reduced after remote ischemic pre-conditioning. Scores in the forelimb placing test and the postural reflex test were significantly lower in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. Thus, neurological function was better in rats having undergone remote ischemic pre-conditioning compared with those who did not receive remote ischemic pre-conditioning. These results indicate that remote ischemic pre-conditioning in rat hindlimb exerts protective effects in ischemia-reperfusion injury.
Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China ; Department of Neurology, Xuanwu Hospital of Capital Medical University, Capital Medical University, Ministry of Education, Beijing 100053, China.
Ying
Y
Zhang
Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China ; Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China.
Xiangrong
X
Liu
Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China ; Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China.
Feng
F
Yan
Department of Neurology, Affiliated Hospital of Liaoning Medical University, Jinzhou 121000, Liaoning Province, China.
Lianqiu
L
Min
Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China ; Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China.
Xunming
X
Ji
Cerebrovascular Diseases Research Institute, Xuanwu Hospital, Capital Medical University, Ministry of Education, Beijing 100053, China ; Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education, Beijing 100053, China.
Yumin
Y
Luo
cerebral ischemia-reperfusion; neural regeneration; remote ischemic preconditioning; stroke