[Research progress in the correlation between insulin resistance and pulmonary arterial hypertension].
Pulmonary arterial hypertension (PAH) is a common clinical syndrome characterized by dysfunction of pulmonary arterioles leading to increased vascular resistance and elevated pulmonary artery pressure. Insulin resistance (IR) is recognized as a critical risk factor for cardiovascular disease, but recent evidence suggested an association between IR and PAH. The pathological consequences of IR, such as hyperinsulinemia, dyslipidemia, chronic inflammation, and oxidative stress can cause pulmonary vasoconstriction, endothelial dysfunction and vascular remodeling, which aggravate the progressive course of PAH. Therefore, addressing the molecular mechanisms by which IR promotes the development of pulmonary hypertension and searching for appropriate interventions are important in the management of PAH.
Respiratory Disease Research Center, Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710004, China.E-mail: ke19870912@163.com.
Rui
R
Ke
Yuanyuan
Y
Wu
Guizuo
G
Wang
Mangxiang
M
Li
D006801:Humans; D006973:Hypertension; D006976:Hypertension, Pulmonary; D007249:Inflammation; D007333:Insulin Resistance; D008168:Lung; D018384:Oxidative Stress; D014661:Vasoconstriction