Proteomics in transplantation.
Proteomics and biochemical profiling have emerged as exciting and powerful tools in clinical biomarker research. In the field of transplantation, proteomics aims not only at developing noninvasive means for immune monitoring but also to gain mechanistic insights into the pathophysiology of the alloimmune response and hence defining new therapeutic targets. This chapter provides an overview of proteomic biomarker-driven approaches and its underlying concepts and discusses the advantages, clinical implications, challenges, and limitations of this novel modality as it relates to solid organ transplantation.
Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
Katrin
K
Kienzl-Wagner
Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: brandacher@jhmi.edu.
Gerald
G
Brandacher
D015415:Biomarkers / Q000032:analysis* / Q000378:metabolism; D006084:Graft Rejection / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D016030:Kidney Transplantation; D013058:Mass Spectrometry / Q000379:methods*; D016377:Organ Transplantation / Q000379:methods*; D011506:Proteins / Q000032:analysis / Q000302:isolation & purification; D040901:Proteomics / Q000379:methods*
D015415:Biomarkers; D011506:Proteins
Biomarker; Diagnosis; Immunosuppression; Proteomics; Rejection; Transplantation