Four new cytotoxic xanthones from Garcinia nujiangensis.
Bioassay-guided fractionation of the acetone extract of the twigs of Garcinia nujiangensis resulted in the isolation of four new prenylated xanthones, nujiangexanthones C-F (1-4), and ten known related analogues. The structures of compounds 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxic effects against three cancer cell lines, the test substances demonstrated selectivity toward the cancer cells.
Minhang Medical First-aid Center of Shanghai, Shanghai 201100, China.
Zhong-Yan
ZY
Tang
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. Electronic address: xiazhengx@sioc.ac.cn.
Zheng-Xiang
ZX
Xia
Minhang Medical First-aid Center of Shanghai, Shanghai 201100, China.
Shi-Ping
SP
Qiao
Minhang Medical First-aid Center of Shanghai, Shanghai 201100, China.
Chao
C
Jiang
Minhang Medical First-aid Center of Shanghai, Shanghai 201100, China.
Guo-Rong
GR
Shen
Minhang Medical First-aid Center of Shanghai, Shanghai 201100, China. Electronic address: 18017108200@163.com.
Mei-Xiang
MX
Cai
Dehong Vocational and Technical College, Dehong 678400, Yunnan, China. Electronic address: ndtangxiaoyan@126.com.
Xiao-Yan
XY
Tang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones
Cudratricusxanthone E (Pubchem CID: 49799569); Cytotoxic; Etoposide I (Pubchem CID: 36462); Garcihombronone B (Pubchem CID: 44559190); Garcinia nujiangensis; Guttiferone F (Pubchem CID: 5352099); Jacareubin (Pubchem CID: 5281644); Nujiangefolin A (Pubchem CID: 66553664); Nujiangefolin B (Pubchem CID: 66553665); Nujiangexanthone A (Pubchem CID: 66553581); Nujiangexanthone B (Pubchem CID: 66553663); Stachyline C (Pubchem CID: 50993978); Xanthone