Luteal phase defect is associated with impaired VEGF mRNA expression in the secretory phase endometrium.
Endometrial morphology and expression of vascular endothelial growth factor (VEGF) was examined in the endometria of women with history of recurrent miscarriage (RM group) and of fertile women without history of gynecological diseases (control group). Luteal phase defect (LPD) was diagnosed in 42% cases in the RM group vs. 13% in controls. Endometrial VEGF mRNA expression was lower in LPD endometria compared to mature endometria. In conclusion, LPD in non-pregnant endometrium is associated with angiogenic abnormalities and may cause pregnancy complications.
Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
Olga N
ON
Sadekova
Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia. Electronic address: lunikit@gmail.com.
Liudmila A
LA
Nikitina
V.F. Snegirev Obstetrics and Gynaecology Clinic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Timur N
TN
Rashidov
Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Irina N
IN
Voloschuk
Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
Larisa M
LM
Samokhodskaya
V.F. Snegirev Obstetrics and Gynaecology Clinic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Elena M
EM
Demidova
Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
Vsevolod A
VA
Tkachuk
D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008183:Luteal Phase / Q000502:physiology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
Angiogenesis; Endometrium; LPD; Recurrent miscarriage; VEGF