Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke.
We examined the relationship between the liver X receptor a gene (LXRα) rsl2221497 polymorphism and the susceptibility to ischemic stroke in a Chinese population. The polymerase chain reaction-restriction fragment length polymorphism technique was used to detect the genotype of rsl2221497 in the LXRαgene of 300 stroke patients and 300 healthy control subjects. The chi-square test was used to analyze the genotype distribution between the 2 groups. We found that the risk of stroke in carriers with the AA + GA genotype was 2.12-fold higher than that in GG genotype carriers (odds ratio = 2.12, 95% confidence interval: 1.58-2.99, P < 0.05). The risk of stroke in carriers of the A allele increased by 1.03-fold compared to that in G allele carriers (odds ratio = 2.03, 95% confidence interval: 1.44-3.01, P < 0.01). After adjusting for other confounding factors such smoking, hypertension, and diabetes, the A allele was found to be an independent risk factor for stroke. Therefore, the rsl2221497 polymorphism in the LXRαgene was associated with the susceptibility to stroke in a Chinese population.
Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin, China wanghx_008@yeah.net.
H X
HX
Wang
Department of Neurology, Binzhou Medical University Hospital, Shandong, China.
K
K
Zhang
Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin, China.
L
L
Zhao
Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin, China.
J W
JW
Tang
Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin, China.
L Y
LY
Gao
Department of Neurology, The Affiliated Fourth Centre Hospital of Tianjin Medical University, Tianjin, China.
Z P
ZP
Wei
D000483:Alleles; D002545:Brain Ischemia / Q000150:complications* / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D000071518:Liver X Receptors; D016015:Logistic Models; D008875:Middle Aged; D057093:Orphan Nuclear Receptors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000235:genetics*
D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors