Soft tissue tumor pathology: New diagnostic immunohistochemical markers.
Recent insights into the pathogenesis of various soft tissue tumors, along with the identification of recurrent molecular alterations characteristic of specific tumor types, have resulted in the development of many diagnostically useful immunohistochemical markers. In some cases, expression of these markers is significantly associated with distinctive clinical and histologic features, which may impart prognostic or predictive information. This review outlines new diagnostic immunohistochemical markers in soft tissue tumor pathology, emphasizing their utility in clinical practice and potential pitfalls, molecular correlates and clinical associations.
Department of Pathology, Brigham and Women׳s Hospital and Harvard Medical School, 75 Francis St, Boston, Massachusetts. Electronic address: ladoyle@partners.org.
Leona A
LA
Doyle
D014408:Biomarkers, Tumor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D009363:Neoplasm Proteins / Q000032:analysis*; D011237:Predictive Value of Tests; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000737:chemistry* / Q000473:pathology
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins
Immunohistochemistry; Molecular genetics; Sarcoma; Soft tissue; Tumor