[Two cases of radiotherapy-induced sarcoma after breast cancer surgery].
We report 2 cases of radiotherapy-induced sarcoma of the residual breast after breast cancer surgery. In 1 case, the patient was a 64-year-old woman. She underwent breast-conserving surgery and axillary lymph node dissection followed by irradiation to the residual breast in July 2001. A 1.1 × 1.0-cm tumor was noted in the residual breast 7 years 5 months after radiotherapy. An excisional biopsy was performed, and a histological diagnosis of angiosarcoma was made. She died of lung and peritoneal metastases 3 years 2 months after the diagnosis. In the other case, the patient was also 64 years old. She underwent breast-conserving surgery and sentinel lymph node biopsy followed by irradiation to the residual breast in October 2006. A 5.7 × 3.9-cm induration was noted in the residual breast 3 years 5 months after radiotherapy. A core needle biopsy was performed, and a histological diagnosis of sarcoma was made. Mastectomy was performed, and the histological diagnosis was malignant fibrous histiocytoma. She died of chest wall and intrapleural tumor recurrence 3 months after the mastectomy. Although radiotherapy-induced sarcoma is rare, early detection of the tumor in the irradiation area is important, as radiotherapy is often performed for breast cancer patients.
Dept. of Surgery, Osaka Saiseikai Senri Hospital.
Shigeyuki
S
Hojo
Setsuko
S
Yoshioka
Yasuhiro
Y
Toyoda
Fumiyoshi
F
Kojima
Toshiki
T
Noma
Hiromichi
H
Miyagaki
Hiroki
H
Matsunaga
Hisashi
H
Nishida
Tatsushi
T
Shingai
Hiroki
H
Fukunaga
Takayuki
T
Fukuzaki
Hiroaki
H
Ohigashi
Yoshiichi
Y
Maeura
D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis*; D011878:Radiotherapy / Q000009:adverse effects; D012509:Sarcoma / Q000175:diagnosis*