Rotavirus vaccine virus shedding, viremia and clearance in infants with severe combined immune deficiency.
We report for the first time Rotarix vaccine-acquired rotavirus infections with viremia in 2 infants vaccinated before being diagnosed with severe combined immune deficiency. Monitoring the first infant revealed that persistent rotavirus infection resolved after complete immune reconstitution was achieved by gene therapy.
From the *National Reference Centre for Enteric Viruses, University Hospital of Dijon, Dijon, France; †Paediatric Immunology, Haematology and Rheumatology Unit, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, and Faculté Paris Descartes, Paris, France; ‡Laboratory of Virology, Necker Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Jérôme
J
Kaplon
Guilhem
G
Cros
Katia
K
Ambert-Balay
Marianne
M
Leruez-Ville
Maryline
M
Chomton
Céline
C
Fremy
Pierre
P
Pothier
Stéphane
S
Blanche
D005260:Female; D015316:Genetic Therapy; D006801:Humans; D007223:Infant; D018655:Lymphocyte Count; D008297:Male; D012401:Rotavirus / Q000502:physiology*; D022243:Rotavirus Vaccines / Q000009:adverse effects*; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy / Q000821:virology*; D019562:Viral Load; D014766:Viremia; D017201:Virus Shedding
D022243:Rotavirus Vaccines