Dynamic nano-interfaces enable harvesting of functional 3D-engineered tissues.
Functional 3D-engineered tissues are successfully harvested from a substrate using stimuli-responsive hydrogel films with dynamic nano-interface. The dynamic wettability control at the interfaces allows cellular detachment, leading to tissue harvesting without serious damage and remaining polymers. This method can be applied to various types of organs and used for tissue transplantation in regenerative medicine.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Akihiro
A
Nishiguchi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Michiya
M
Matsusaki
Department of Surgery, Division of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0087, Japan.
Shigeru
S
Miyagawa
Department of Surgery, Division of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka, 565-0087, Japan.
Yoshiki
Y
Sawa
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Mitsuru
M
Akashi
D002448:Cell Adhesion; D002470:Cell Survival / Q000187:drug effects; D006331:Heart Diseases / Q000628:therapy; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D057026:Induced Pluripotent Stem Cells / Q000166:cytology / Q000378:metabolism; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*
D011108:Polymers; D011099:Polyglutamic Acid; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
cell adhesion; dynamic interfaces; gels; thin films; tissue engineering