An integrated biopsychosocial model of childhood maltreatment and psychosis.
There is now a well-established link between childhood maltreatment and psychosis. It is, however, unclear what the mechanisms are by which this occurs. Here, we propose a pathway linking the experience of childhood maltreatment with biological changes in the brain and suggest a psychological intervention to ameliorate its effects.
Victoria Barker, PhD, MRCPsych, MAcadMEd, AFHEA, Division of Psychiatry, Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh; Andrew Gumley, MAppSci, PhD, CPsychol, AFBPsS, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow; Matthias Schwannauer, MA, MSc, DPsych, PhD, CPsychol, AFBPS, Stephen M. Lawrie, MRCPsych, MPhil, MD (Hons), FRCPsych, Hon FRCP (Edin), Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Victoria
V
Barker
Victoria Barker, PhD, MRCPsych, MAcadMEd, AFHEA, Division of Psychiatry, Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh; Andrew Gumley, MAppSci, PhD, CPsychol, AFBPsS, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow; Matthias Schwannauer, MA, MSc, DPsych, PhD, CPsychol, AFBPS, Stephen M. Lawrie, MRCPsych, MPhil, MD (Hons), FRCPsych, Hon FRCP (Edin), Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Andrew
A
Gumley
Victoria Barker, PhD, MRCPsych, MAcadMEd, AFHEA, Division of Psychiatry, Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh; Andrew Gumley, MAppSci, PhD, CPsychol, AFBPsS, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow; Matthias Schwannauer, MA, MSc, DPsych, PhD, CPsychol, AFBPS, Stephen M. Lawrie, MRCPsych, MPhil, MD (Hons), FRCPsych, Hon FRCP (Edin), Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Matthias
M
Schwannauer
Victoria Barker, PhD, MRCPsych, MAcadMEd, AFHEA, Division of Psychiatry, Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh; Andrew Gumley, MAppSci, PhD, CPsychol, AFBPsS, Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow; Matthias Schwannauer, MA, MSc, DPsych, PhD, CPsychol, AFBPS, Stephen M. Lawrie, MRCPsych, MPhil, MD (Hons), FRCPsych, Hon FRCP (Edin), Centre for Brain Sciences, School of Clinical Sciences, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.
Stephen M
SM
Lawrie
D054523:Adult Survivors of Child Abuse / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D057890:Epigenomics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008960:Models, Psychological; D010121:Oxytocin / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011613:Psychotherapy; D011618:Psychotic Disorders / Q000503:physiopathology* / Q000523:psychology* / Q000628:therapy
D019208:Brain-Derived Neurotrophic Factor; D010121:Oxytocin