T-helper cell-mediated factors in drug-induced liver injury.
Drug-induced liver injury (DILI) leads to a large burden on the healthcare system due to its potential morbidity and mortality. The key for predicting and preventing DILI is to understand the underlying mechanisms. Hepatic inflammation is one of the most common features of DILI. The inflammation can be attributed to the innate immune response. The adaptive immune system is also affected by the innate immune response resulting in liver damage. T-helper cells are important regulators of acquired immunity. T-helper cell-mediated immune responses play pivotal roles in the pathogenesis of a variety of liver disorders. This review summarizes recent advances in the T-helper cell-mediated factors in DILI and potential mechanisms, which may lead to a better understanding of DILI.
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, People's Republic of China.|Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, People's Republic of China.
Xinzhi
X
Wang
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, People's Republic of China.|Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, Nanjing, People's Republic of China.
Luyong
L
Zhang
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, People's Republic of China.|Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Nanjing, People's Republic of China.
Zhenzhou
Z
Jiang
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*
D016207:Cytokines; D007375:Interleukin-1
Cytokine; Drug-induced liver injury; Notch; SOCS; STAT; T-helper cells