Nasobiliary drainage after endoscopic papillary balloon dilatation may prevent postoperative pancreatitis.
OBJECTIVE
To evaluate the necessity of endoscopic nasobiliary drainage (ENBD) catheter placement after clearance of common bile duct (CBD) stones.


METHODS
Patients enrolled in this study were randomly divided into two groups, according to whether or not they received ENBD after the removal of CBD stones. Group 1 (ENBD group) was then subdivided into three groups: G1a patients received an endoscopic papillary balloon dilatation (EPBD), G1b patients received an endoscopic sphincterotomy (EST), and G1c patients received neither. Group 2 (non-ENBD group) patients were also subdivided into three groups (G2a, G2b, and G2c), similar to Group 1. The maximum CBD diameter, the time for C-reactive protein (CRP) to normalize, levels of serum amylase, total serum bilirubin (TB) and alanine aminotransferase (ALT), and postoperative hospitalization duration (PHD) were measured.


RESULTS
A total of 218 patients (139 males, 79 females), with an average age of 60.1±10.8 years, were enrolled in this study. One hundred and thirteen patients who received ENBD were included in Group 1, and 105 patients who did not receive ENBD were included in Group 2. The baseline clinical characteristics were similar in both groups. There were no significant differences in post-endoscopic retrograde cholangiopancreatography (ERCP)-related complications when Groups 1 and 2 were compared. Seventy-seven patients underwent EPBD, and 41 received an ENBD tube (G1a) and 36 did not (G2a). Seventy-three patients underwent EST, and 34 patients received an ENBD tube (G1b) and 39 did not (G2b). The remaining 68 patients underwent neither EPBD nor EST; of these patients, 38 received an ENBD tube (G1c) and 30 did not (G2c). For each of the three pairs of subgroups (G1a vs G2a, G1b vs G2b, G1c vs G2c), there were no significant differences detected in the PHD or the time to normalization of CRP, TB and ALT. In the EPBD group, the incidence of post-ERCP pancreatitis, hyperamylasemia and overall patient complications was significantly higher for G2a (post-ERCP pancreatitis: 6/36 vs 0/41, P=0.0217; hyperamylasemia: 11/36 vs 4/41, P=0.0215; overall patient complications: 18/36 vs 7/41, P=0.0029).


CONCLUSIONS
After successful CBD stone clearance, ENBD is only beneficial when an EPBD procedure has been performed.
Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 215500, Jiangsu Province, China.
Xiao-Dan
XD
Xu
Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 215500, Jiangsu Province, China.
Jian-Jun
JJ
Dai
Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 215500, Jiangsu Province, China.
Jian-Qing
JQ
Qian
Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 215500, Jiangsu Province, China.
Wei-Jun
WJ
Wang
D000368:Aged; D015415:Biomarkers / Q000097:blood; D057785:Catheters; D002681:China; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects / Q000379:methods*; D042883:Choledocholithiasis / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D004106:Dilatation; D004322:Drainage / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D018579:Patient Selection; D011446:Prospective Studies; D012307:Risk Factors; D016717:Sphincterotomy, Endoscopic; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers
Endoscopic nasobiliary drainage; Endoscopic papillary balloon dilatation; Hyperamylasemia; Post-endoscopic retrograde cholangiopancreatography pancreatitis