Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats: A biochemical and histological study.
5-Fluorouracil is one of the most commonly used anticancer drugs for the treatment of various types of cancer but has potential adverse effects such as intestinal mucositis, renal, hepatic, and reproductive organ toxicity. Attention has been given to approaches to reduce the side effects and improve the therapeutic effectiveness of chemotherapeutic drugs. In this study, we have investigated the protective effect of taurine (Tau) on 5-fluorouracil (5-FU) induced adverse effects in Wistar rats. Animals were divided into four groups with six animals (n = 6) in each group. Group I received vehicle only and served as control group. Groups II, III, and IV animals were given oral gavage of 5-FU at 50 mg/kg body weight for 4 days. Tau was given to the animals of groups III and IV 30 min prior to 5-FU administration. We observed marked elevation in the myeloperoxidase (MPO) activity after 5-FU administration, which was reversed by Tau pretreatment. Histological observation of liver, kidney, intestine, testis, and prostate revealed that 5-FU administration resulted in anomalies like distortion of normal cellular architecture, infiltration of inflammatory cells, and loss of cellular integrity. These histopathological changes were markedly suppressed by Tau treatment. In conclusion, biochemical and histological findings of this study suggest that Tau has strong preventive potential against complications of anticancer drug 5-FU and hence Tau may play an important role in combinational chemotherapy to enhance the therapeutic efficacy of anticancer drugs.
Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia abdulrahman.alasmari@gmail.com.
A K
AK
Al-Asmari
Department of Oncology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
A M
AM
Al-Zahrani
Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
A Q
AQ
Khan
Department of Ophthalmology, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
H M
HM
Al-Shahrani
Research Center, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
M
M
Ali Al Amri
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000633:toxicity*; D007410:Intestinal Diseases / Q000139:chemically induced*; D007422:Intestines / Q000166:cytology / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008407:Mast Cells; D052016:Mucositis / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*; D013733:Testicular Diseases / Q000139:chemically induced*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D013654:Taurine; D005472:Fluorouracil
5-fluorouracil; Cancer; histology; inflammation; taurine