Frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del in healthy Polish individuals.
Polymorphisms within genes coding innate immune response proteins are involved in genetic susceptibility to various conditions. We investigated the frequency of P2RX7 A1513C and TLR2 -196 to -174 ins/del polymorphisms in healthy Polish population. Frequency of minor alleles was relatively similar to the pattern presented by Caucasian populations while it differed significantly when compared to non-European populations, which could be a result of variable selection pressure put upon studied alleles or hindered gene flow between populations.
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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M
Lewandowska
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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Garczyńska
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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Jędrychowska-Dańska
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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Kopczyńska
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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Masłowska
Department of Molecular Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University, Lodz, Poland.
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H
Witas
D000328:Adult; D000483:Alleles; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D064368:Healthy Volunteers; D006801:Humans; D054643:INDEL Mutation; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D044465:White People / Q000235:genetics*; D055815:Young Adult
D058486:Receptors, Purinergic P2X7; D051195:Toll-Like Receptor 2