Epigenetic signatures of obesity.
A study in drosophila shows that the progeny of male flies briefly fed a diet with abnormally high or low sugar levels are more susceptible to obesity. The data suggest that epigenetic susceptibility factors are at play not only in flies but in humans and mice as well.
Susan E
SE
Ozanne
D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D002241:Carbohydrates / Q000008:administration & dosage; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D004032:Diet; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D008745:Methylation; D009765:Obesity / Q000235:genetics; D013094:Spermatozoa / Q000378:metabolism; D014158:Transcription, Genetic; D014280:Triglycerides / Q000032:analysis
D002241:Carbohydrates; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D014280:Triglycerides