WU and KI polyomaviruses in respiratory, blood and urine samples from renal transplant patients.
BACKGROUND
It is suggested that immunosuppression due to transplantation might be a risk for human polyomavirus KI (KIPyV) and WU (WUPyV) infection. Most of the publications report data about stem cell transplant patients, little is known about these virus infections in renal transplant patients.


OBJECTIVE
To study the presence of KIPyV and WUPyV in upper respiratory, plasma and urine samples from renal transplant patients. To analyse clinical and personal data.


METHODS
532 respiratory, 503 plasma and 464 urine samples were collected from 77 renal transplant patients. KIPyV and WUPyV were detected by nested and quantitative real-time PCR. Patient and clinical data from medical records were analyzed.


RESULTS
KIPyV was detected in respiratory, plasma and urine samples from 14.3%, 3.9% and 4.1% of renal transplant patients. WUPyV was found in respiratory and plasma specimens from 9.1% and 5.3% of the patients. Significant association was revealed between the detection of KIPyV and WUPyV and the time of samples collection and the age of the patients. KIPyV was presented in respiratory and plasma sample at the same time. KIPyV was detected in plasma samples from two patients and in urine samples of three other patients providing also KIPyV positive respiratory samples at the same time. No clinical consequences of KIPyV or WUPyV infection were found.


CONCLUSIONS
Although no clinical consequences of KIPyV and WUPyV infections were found in renal transplant patients, it is suggested that renal transplantation might result in higher susceptibility or reactivation of these infection.
Department of Medical Microbiology, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary. Electronic address: csomae@freemail.hu.
Eszter
E
Csoma
Department of Medical Microbiology, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary.
Beáta
B
Mészáros
First Department of Surgery, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary.
László
L
Asztalos
Department of Medical Microbiology, University of Debrecen, Nagyerdei krt. 98., H-4032 Debrecen, Hungary.
Lajos
L
Gergely
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000821:virology*; D060888:Real-Time Polymerase Chain Reaction; D012137:Respiratory System / Q000821:virology*; D012141:Respiratory Tract Infections / Q000821:virology*; D066027:Transplant Recipients; D019562:Viral Load; D014766:Viremia; D055815:Young Adult
Human polyomaviruses; Immunocompromised patients; KIPyV; Renal transplanta; WUPyV