Serum osteopontin concentrations in relation to coronary artery disease.
OBJECTIVE
Coronary artery disease (CAD) is a common form of vascular disease and is associated with high mortality and morbidity globally. It has been suggested that serum osteopontin (OPN) may be a useful biomarker of atherosclerosis and vascular calcification. The aim of this study was to assess the association between serum OPN levels and severity of CAD.


METHODS
Three hundred and four subjects were studied, 111 with clinically significant angiographically defined CAD (CAD+) (>50% stenosis), 96 with negative angiography (CAD-) (<50% stenosis) and 97 healthy controls. Fasting blood samples were collected from all patients before coronary angiography and serum OPN levels were determined using ELISA.


RESULTS
Serum concentrations of OPN were significantly higher in both CAD+ (72.99 [51.05-103.64]) and CAD- (11.11 [8.11-18.23]) (p = 0.001) groups compared with the control group (5.99 [4.26-7.91]) (p = 0.001). CAD+ subjects also had higher serum OPN levels compared with CAD-subjects (p = 0.001). However, OPN levels were comparable between subgroups of CAD+ subjects stratified according to the number of narrowed vessels in angiography.


CONCLUSIONS
The present results suggest a positive association between circulating OPN concentrations and the presence but not the extent of CAD.
Department of Clinical Pharmacy, Pharmaceutical Research Center & School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir Hooshang
AH
Mohamadpour
Department of Clinical Pharmacy, Pharmaceutical Research Center & School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Leila
L
Abdolrahmani
Departments of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamed
H
Mirzaei
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirhosein
A
Sahebkar
Departments of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen
M
Moohebati
Departments of Pharmacology and Toxicology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Maryam
M
Ghorbani
Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
Gordon A
GA
Ferns
Biochemistry of Nutrition Research Center, Cardiovascular Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
Majid
M
Ghayour-Mobarhan
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood*; D012307:Risk Factors; D061205:Vascular Calcification / Q000097:blood*
D015415:Biomarkers; D053495:Osteopontin
Atherosclerosis; Coronary artery disease; Osteopontin