Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases.
Kinesin superfamily proteins (KIFs) largely serve as molecular motors on the microtubule system and transport various cellular proteins, macromolecules, and organelles. These transports are fundamental to cellular logistics, and at times, they directly modulate signal transduction by altering the semantics of informational molecules. In this review, we will summarize recent approaches to the regulation of the transport destinations and to the physiological relevance of the role of these proteins in neuroscience, ciliary functions, and metabolic diseases. Understanding these burning questions will be essential in establishing a new paradigm of cellular functions and disease pathogenesis.
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence in Genome Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: hirokawa@m.u-tokyo.ac.jp.
Nobutaka
N
Hirokawa
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yosuke
Y
Tanaka
D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*; D008659:Metabolic Diseases / Q000378:metabolism*
D016547:Kinesins
Brain development; Cilia; Embryonic development; Intracellular transport; KIFs; Kinesin; Learning and memory; Metabolic diseases; Molecular motor