Gold nanoparticle/polymer nanocomposite for highly sensitive drug-DNA interaction.
The interaction of the anticancer drug mitomycin C (MC) and DNA immobilized on gold a nanoparticle/polyvinylferrocenium (AuNP/PVF(+)) coated electrode is presented. This is the first attempt to prepare a biocompatible nanoparticle/redox polymer composite in a one-step and easy electropolymerization procedure and then use the coated electrode for MC-DNA interaction. The prepared electrode exhibits high sensitivity for the investigation of drug-DNA interaction.
Department of Chemistry, Faculty of Arts and Sciences, Ordu University, 52200 Ordu, Turkey.
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Kuralay
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Erdem
D000225:Adenine / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods*; D005296:Ferrous Compounds / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D016685:Mitomycin / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010084:Oxidation-Reduction; D058105:Polymerization; D011145:Polyvinyls / Q000737:chemistry*
D005296:Ferrous Compounds; D011145:Polyvinyls; C451099:polyvinylferrocenium; D016685:Mitomycin; D006147:Guanine; D006046:Gold; D004247:DNA; D000225:Adenine