Molecular and phenotypic characterization of methicillin-resistant Staphylococcus aureus isolates causing bacteremia at a major hospital in southern Mississippi.
Staphylococcus aureus is the predominant cause of bacteremia worldwide. We assessed the molecular epidemiology and antibiotic resistance of methicillin-resistant S aureus isolates causing bacteremia in southern Mississippi. Diverse genetic backgrounds in terms of staphylococcal cassette chromosome mec, pulsed-field gel electrophoresis, and multilocus sequence typing types of methicillin-resistant S aureus were identified as causing bacteremia in Mississippi. A strong association of Panton-Valentine leukocidin genes with elevated vancomycin minimum inhibitory concentration is one of the important findings of our study.
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS.
Dhritiman
D
Samanta
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS.
Justin L
JL
Batte
Department of Infectious Diseases, Forrest General Hospital, Hattiesburg, MS.
Stephanie N
SN
Brown
Molecular Diagnostics, Mississippi State Department of Health Laboratory, Jackson, MS.
Angela G
AG
Crosby
Department of Infectious Diseases, Forrest General Hospital, Hattiesburg, MS.
Luis A
LA
Marcos
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS. Electronic address: mohamed.elasri@usm.edu.
Mohamed O
MO
Elasri
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology*; D001427:Bacterial Toxins / Q000235:genetics; D004361:Drug Tolerance; D016521:Electrophoresis, Gel, Pulsed-Field; D005098:Exotoxins / Q000235:genetics; D014644:Genetic Variation; D006761:Hospitals; D006801:Humans; D007956:Leukocidins / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D008922:Mississippi / Q000453:epidemiology; D017720:Molecular Epidemiology; D058885:Multilocus Sequence Typing; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D014640:Vancomycin / Q000494:pharmacology; D037521:Virulence Factors / Q000235:genetics
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors; D014640:Vancomycin
Epidemiology; PVL; Vancomycin