Regioselective annulation of nitrosopyridine with alkynes: straightforward synthesis of N-oxide-imidazopyridines.
We have developed a novel method for the regioselective annulation of 2-nitrosopyridines with variably substituted alkynes under mild reaction conditions. This approach allows the annulation of alkynes with 2-nitrosopyridines under reagent- and catalyst-free reaction conditions. The developed method shows excellent functional group tolerance and provides easy access to N-oxide-imidazo[1,2-a]pyridines.
Max-Planck Institute of Molecular Physiology, Abteilung Chemische Biologie, Otto-Hahn Strasse 11, 44227, Dortmund, Germany. Andrey.Antonchick@mpi-dortmund.mpg.de.
Srimanta
S
Manna
Rishikesh
R
Narayan
Christopher
C
Golz
Carsten
C
Strohmann
Andrey P
AP
Antonchick
D000480:Alkynes / Q000737:chemistry*; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D009603:Nitroso Compounds; D011725:Pyridines