Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems.
Among the materials for preparing the polymeric nanocarriers, poly(n-butylcyanoacrylate) (PBCA), a polymer with medium length alkyl side chain, is of lower toxicity and proper degradation time. Therefore, PBCA has recently been regarded as a kind of widely used, biocompatible, biodegradable, low-toxic drug carrier. This review highlights the use of PBCA-based nanocarriers (PBCA-NCs) as targeting drug delivery systems and presents the methods of preparation, the surface modification and the advantages and limitations of PBCA-NCs. The drugs loaded in PBCA-NCs are summarized according to the treatment of diseases, and the different therapeutic applications and the most recent developments of PBCA-NCs are also discussed, which provides useful guidance on the targeting research of PBCA-NCs.
Department of Pharmacy, State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing , People's Republic of China .
Shiya
S
Gao
Yurui
Y
Xu
Sajid
S
Asghar
Minglei
M
Chen
Lang
L
Zou
Sulieman
S
Eltayeb
Meirong
M
Huo
Qineng
Q
Ping
Yanyu
Y
Xiao
D055598:Chemical Phenomena; D004337:Drug Carriers / Q000008:administration & dosage* / Q000138:chemical synthesis; D065546:Drug Liberation; D004355:Drug Stability; D004659:Enbucrilate / Q000008:administration & dosage* / Q000138:chemical synthesis; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D013499:Surface Properties
D004337:Drug Carriers; D004659:Enbucrilate
Pharmaceutical applications; poly(butylcyanoacrylate); polymeric nanocarriers; targeted drug delivery