[Advantages and special features of hospital preparations of parenteral nutrition in neonatalogy].
BACKGROUND
The care of premature infants requires specific, suitable parenteral nutrition, in which the dosage must be frequently adjusted.


METHODS
A comparative analysis of four industrial standard parenteral nutrition formulations NP 100®, Pediaven AP-HP Nouveau-né 1®, Pediaven AP-HP Nouveau-né 2® and Numetah G13% E® and of two hospital preparations made specifically in hospital pharmacies produced by two separate university hospitals (Nutrine® HCL and Formule standardisée début de nutrition) was conducted. The comparison between the formulations focused on electrolytic compositions and protein/energy ratio.


RESULTS
Formule standardisée début de nutrition and Pediaven AP-HP Nouveau-né 1® are free from (i) sodium and potassium, (ii) potassium respectively. Almost equivalent sodium concentration (19-27 mM) and more variable potassium concentration (∼9-26 mM) characterize the other formulations. Protein/energy ratio of Numetah G13% E®, Nutrine® HCL and Formule standardisée début de nutrition is 58% higher than that of NP 100®, Pediaven AP-HP Nouveau-né 1® and Pediaven AP-HP Nouveau-né 2®.


CONCLUSIONS
Formule standardisée début de nutrition and Pediaven AP-HP Nouveau-né 1® are in accordance with the recommendations about hydro-electrolytic supplies during transition phase. Nutrine® HCL complies best to the recommendations about hydro-electrolytic account during stabilization phase.


CONCLUSIONS
Hydro-electrolytic composition and protein/energy ratio of standard hospital parenteral nutrition formulations comply best to nutritional needs of premature infants.
Service pharmaceutique, plateforme FRIPHARM, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
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Baudouin
Service pharmaceutique, plateforme FRIPHARM, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
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Diouf
Service pharmaceutique, plateforme FRIPHARM, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
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Tall
Service pharmaceutique, hôpital Clocheville, centre hospitalier régional universitaire de Tours, 49, boulevard Béranger, 37044 Tours cedex 9, France.
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Duval
Service pharmaceutique, hôpital Clocheville, centre hospitalier régional universitaire de Tours, 49, boulevard Béranger, 37044 Tours cedex 9, France.
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Provôt
Service néonatalogie et réanimation néonatale, groupement hospitalier Nord, hospices civils de Lyon, 103, Grande-Rue-de-la-Croix-Rousse, 69004 Lyon, France.
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Picaud
Service réanimation néonatale, hôpital Femme-Mère-Enfant, groupement hospitalier Est, hospices civils de Lyon, 59, boulevard Pinel, 69500 Bron, France.
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Claris
Service pharmaceutique, plateforme FRIPHARM, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
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Pivot
Service pharmaceutique, plateforme FRIPHARM, groupement hospitalier Édouard-Herriot, hospices civils de Lyon, 5, place d'Arsonval, 69437 Lyon cedex 03, France; EA 4169 « Fonctions normales et pathologiques de la barrière cutanée », laboratoire de pharmacie galénique industrielle, plateforme FRIPHARM, faculté de Pharmacie, 8, avenue Rockefeller, 69373 Lyon cedex 08, France. Electronic address: fabrice.pirot@univ-lyon1.fr.
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Pirot
D004339:Drug Compounding; D005526:Food, Formulated / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D009359:Neonatology / Q000379:methods*; D010288:Parenteral Nutrition / Q000379:methods*
Apports énergétiques; Energy supply; Faible poids de naissance; Low birth weight; Neonatalogy; Nutrition parentérale; Néonatalogie; Parenteral nutrition; Premature infant; Prématurés