An efficient synthesis of 3,4-Dihydropyrimidin-2(1H)-ones and thiones catalyzed by a novel Brønsted acidic ionic liquid under solvent-free conditions.
We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst.
Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China. zhzhzyh@126.com.|Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. zhzhzyh@126.com.
Yonghong
Y
Zhang
Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China. wangbin.yang@163.com.
Bin
B
Wang
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China. xmzhang@cioc.ac.cn.
Xiaomei
X
Zhang
Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China. jbhuang@pku.edu.cn.
Jianbin
J
Huang
Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China. pxylcj@126.com.|Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China. pxylcj@126.com.
Chenjiang
C
Liu
D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D052578:Ionic Liquids / Q000494:pharmacology*; D011744:Pyrimidinones / Q000138:chemical synthesis*; D012997:Solvents; D013871:Thiones / Q000138:chemical synthesis*; D013890:Thiourea / Q000737:chemistry*
D000447:Aldehydes; D052578:Ionic Liquids; D011744:Pyrimidinones; D012997:Solvents; D013871:Thiones; D013890:Thiourea