A mouse model of skin aging: fragmentation of dermal collagen fibrils and reduced fibroblast spreading due to expression of human matrix metalloproteinase-1.
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Wei
W
Xia
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Taihao
T
Quan
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Craig
C
Hammerberg
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
John J
JJ
Voorhees
Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: gjfisher@med.umich.edu.
Gary J
GJ
Fisher
D000367:Age Factors; D000818:Animals; D048430:Cell Shape; D024022:Fibrillar Collagens / Q000378:metabolism*; D005347:Fibroblasts / Q000201:enzymology* / Q000473:pathology; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D008822:Mice, Transgenic; D023421:Models, Animal; D012867:Skin / Q000201:enzymology* / Q000473:pathology; D015595:Skin Aging
D024022:Fibrillar Collagens; C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1
Aging; Collagen; Fibroblast; MMP-1; Skin; Transgenic mice