Invasive, atypical and aggressive pituitary adenomas and carcinomas.
Aggressive pituitary adenomas have a high risk of recurrence, a lack of therapeutic response, and resistance to conventional treatment. So far, no satisfactory biomarkers are available for predicting their behavior. Some specific pituitary adenoma histotypes are more prone to follow an aggressive behavior. Pituitary carcinomas are rare and show cerebrospinal and/or systemic metastasis. They have worse prognosis than aggressive adenomas, and radiation is of limited use in their treatment.
Department of Pathology, Acibadem University, School of Medicine, Kerem Aydinlar Yerleskesi, Icerenkoy Mahallesi, Kayisdagi Caddesi, No: 32, Atasehir, Istanbul, Turkey. Electronic address: murataydinsav@gmail.com.
Aydin
A
Sav
Division of Pathology, Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Fabio
F
Rotondo
Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia.
Luis V
LV
Syro
Department of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Antonio
A
Di Ieva
Department of Neurosurgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Michael D
MD
Cusimano
Division of Pathology, Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Kalman
K
Kovacs
D000236:Adenoma / Q000145:classification*; D002277:Carcinoma / Q000145:classification*; D006801:Humans; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000145:classification*
Aggressive pituitary adenoma; Atypical adenoma; Diagnosis; Invasive adenoma; Noninvasive adenoma; Pituitary carcinoma