Role of salvage stereotactic body radiation therapy in post-surgical loco-regional recurrence in a selected population of non-small cell lung cancer patients.
OBJECTIVE
This is a retrospective analysis of a selected series of high-risk non-small cell lung cancer (NSCLC) patients with post-surgical loco-regional relapse treated with salvage stereotactic body radiotherapy (SBRT). Outcome and toxicity profiles were assessed.


METHODS
Twenty-eight patients (unfit for surgery or systemic therapy) with 30 lesions underwent salvage SBRT as an alternative therapy because of advanced age, co-morbid conditions or no response obtained from other treatments.


RESULTS
Complete and partial responses were 16% and 70%, respectively. Local progression was observed in 3 patients. Regional relapse occurred in 5 patients. Distant progression occurred in 10 patients. The 2-year overall survival (OS) and disease-free survival (DFS) were 57.5% and 36.6%, respectively. Radiation acute pneumonitis occurred as follows: three patients developed grade 1, two patients experienced grade 2 and one patient experienced grade 3 toxicity.


CONCLUSIONS
Stereotactic body radiotherapy could have an alternative role in isolated loco-regional relapse in patients unfit or resistant to other therapies.
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy linda.agolli@gmail.com.
Linda
L
Agolli
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Maurizio
M
Valeriani
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Alessia
A
Carnevale
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Teresa
T
Falco
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Stefano
S
Bracci
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Vitaliana
V
De Sanctis
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli (IS), Italy.
Giuseppe
G
Minniti
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Riccardo Maurizi
RM
Enrici
Institute of Radiation Oncology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Mattia Falchetto
MF
Osti
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects; D016879:Salvage Therapy
Salvage stereotactic radiotherapy; local control; non-small cell lung cancer; post-surgical recurrence