Impact of insulin-like growth factor 1 and insulin-like growth factor binding proteins on outcomes in acute myeloid leukemia.
Our objective was to explore associations of circulating factors implicated in insulin-like growth factor- 1 receptor (IGF-1R) signaling with clinical outcomes of patients with acute myeloid leukemia (AML). Pretreatment blood samples from patients with non-M3 AML (n = 30) were collected prospectively and levels of IGF binding proteins (IGFBPs) 1-7 and IGF-1 (free and total) were established at diagnosis and statistically evaluated. Baseline levels of IGFBP-1 and -6 below respective thresholds of 8.8 ng/mL and 237 ng/mL were associated (p = 0.0347 and 0.0099, respectively) with superior progression-free survival, whereas baseline levels of IGFBP -1, -2, -6 and -7 below the respective thresholds of 8.8, 28.8, 237 and 119 ng/mL were strongly associated (p = 0.0004, 0.0085, 0.0031, 2.46 × 10(- 7), respectively) with improved overall survival. These findings provide promising evidence that IGFBP signatures could be used as predictive tools in AML, with applications in remission surveillance and the development of IGFBP-directed biologic therapy.
a Section of Hematology Division of Hematology/Oncology/Cell Therapy , Chicago , IL , USA.
Reem
R
Karmali
a Section of Hematology Division of Hematology/Oncology/Cell Therapy , Chicago , IL , USA.
Melissa L
ML
Larson
a Section of Hematology Division of Hematology/Oncology/Cell Therapy , Chicago , IL , USA.
Jamile M
JM
Shammo
b Section of Preventative Medicine , Chicago , IL , USA.
Sanjib
S
Basu
a Section of Hematology Division of Hematology/Oncology/Cell Therapy , Chicago , IL , USA.
Kent
K
Christopherson
c Division of Pathology , Chicago , IL , USA.|d Division of Biochemistry, Rush University Cancer Center , Chicago , IL , USA.
Jeffrey A
JA
Borgia
a Section of Hematology Division of Hematology/Oncology/Cell Therapy , Chicago , IL , USA.
Parameswaran
P
Venugopal
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
D015415:Biomarkers; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I
AML; IGF-1; IGFBPs; Luminex; clinical outcome