Cyclic sulfoxides-garlicnins K1, K2, and H1-extracted from Allium sativum.
Newly identified cyclic sulfoxides-garlicnins K1 (1), K2 (2), and H1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin H1 (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K1 and K2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.
Faculty of Pharmaceutical Sciences, Sojo University.
Toshihiro
T
Nohara
Yukio
Y
Fujiwara
Yusuke
Y
Komota
Yoshihiko
Y
Kondo
Taiki
T
Saku
Koki
K
Yamaguchi
Yoshihiro
Y
Komohara
Motohiro
M
Takeya
D015703:Antigens, CD / Q000032:analysis / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis / Q000378:metabolism; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D005737:Garlic / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000032:analysis / Q000378:metabolism; D013454:Sulfoxides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000098902:CD163 Antigen
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D010936:Plant Extracts; D011956:Receptors, Cell Surface; D013454:Sulfoxides; C000603223:garlicnin H1; C000603221:garlicnin K1; C000603222:garlicnin K2