Chitosan finishing nonwoven textiles loaded with silver and iodide for antibacterial wound dressing applications.
Polyethylene terephtalate (PET) and Polypropylene (PP) textiles are widely used in biomedical application such as wound dressings and implants. The aim of this work was to develop an antibacterial chitosan (CHT) coating activated by silver or by iodine. Chitosan was immobilized onto PET and PP supports using citric acid (CTR) as a crosslinking agent through a pad-dry-cure textile finishing process. Interestingly, depending on the CHT/CTR molar ratio, two different systems were obtained: rich in cationic ammonium groups when the CTR concentration was 1%w/v, and rich in anionic carboxylate groups when the CTR concentration was 10%w/v. As a consequence, such samples could be selectively loaded with iodine and silver nitrate, respectively.Both types of coatings were analyzed using SEM and FTIR, their sorption capacities were evaluated toward iodide/iodate anions (I(-)/IO3(-)) and the silver cations (Ag(+)) were evaluated using elemental analysis. Finally, in vitro evaluations were carried out to evaluate the cytocompatibility on the epithelial cell line. The silver loaded textile reported a stronger antibacterial effect against E.coli (5 log10 reduction) than toward S. aureus (3 log10) while the antibacterial effect of the iodide loaded textiles was limited to 1 log10 to 2 log10 on both strains.
INSERM U1008, Groupe de Recherche sur les Biomatériaux, Université Lille 2, F-59045 Lille, France.
François
F
Aubert-Viard
Adeline
A
Martin
Feng
F
Chai
Christel
C
Neut
Nicolas
N
Tabary
Bernard
B
Martel
Nicolas
N
Blanchemain
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival; D048271:Chitosan / Q000737:chemistry*; D019343:Citric Acid / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007454:Iodides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013784:Textiles; D014048:Tolonium Chloride / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D003432:Cross-Linking Reagents; D007454:Iodides; D011093:Polyethylene Terephthalates; D011126:Polypropylenes; D014048:Tolonium Chloride; D019343:Citric Acid; D012834:Silver; D048271:Chitosan