Clinical features of psoriatic uveitis in Japanese patients.
OBJECTIVE
To investigate the clinical features of psoriatic uveitis in Japanese patients.


METHODS
Clinical features of 13 consecutive patients with psoriatic uveitis treated at our facility were retrospectively examined using medical records. In this study, we collected data about psoriasis type, uveitis laterality, onset type, HLA types, visual acuity, ocular inflammation localization, anterior segment findings, funduscopy findings, complications, recurrence, and medical treatments for uveitis and skin diseases.


RESULTS
The cohort comprised ten males and three females (43.6 ± 7.1 years old), and types of psoriasis included psoriasis vulgaris (seven cases), psoriatic arthritis (four cases), pustular psoriasis (three cases) and psoriatic erythroderma (one case). Two cases represented complicated cases of pustular psoriasis and psoriatic arthritis. Seven cases were unilateral, and six cases were bilateral. All cases had acute non-granulomatous anterior uveitis, whereas panuveitis occurred in one case. Furthermore, macular edema and vascular leakage on fluorescein angiography occurred in four cases, and hyperemic disc occurred in two cases. Recurrence occurred in nine cases. In addition to topical corticosteroid treatment, eight cases underwent oral immunosuppressive treatment or biologics. All six cases undergoing HLA typing were HLA-A2 positive.


CONCLUSIONS
Cases of psoriatic uveitis in Japan appear to present with acute non-granulomatous uveitis; other symptoms may include macular edema, retinal vasculitis, or hyperemic disc.
Department of Ophthalmology, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan, rtanaka-ymn@umin.ac.jp.
Rie
R
Tanaka
Mitsuko
M
Takamoto
Keiko
K
Komae
Kazuyoshi
K
Ohtomo
Yujiro
Y
Fujino
Toshikatsu
T
Kaburaki
D000328:Adult; D017668:Age of Onset; D044466:Asian People / Q000208:ethnology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D015789:HLA-A2 Antigen / Q000032:analysis; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000208:ethnology; D012189:Retrospective Studies; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000188:drug therapy / Q000208:ethnology
D005938:Glucocorticoids; D015789:HLA-A2 Antigen; D007166:Immunosuppressive Agents