Chromatin methylation and cardiovascular aging.
DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
Institute of Molecular Biology and Pathology, National Research Council (IBPM-CNR), Rome, Italy.
Barbara
B
Illi
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Rome, Italy.
Roberta
R
Ciarapica
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), Rome, Italy. Electronic address: capogrossi@idi.it.
Maurizio C
MC
Capogrossi
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006333:Heart Failure / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D063146:Polycomb-Group Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D002843:Chromatin; D006657:Histones; D063146:Polycomb-Group Proteins
Aging; Cardiovascular disease; DNA methylation; Histone methylation