Order from the order: how a spatiotemporal genetic program is encoded in a 2-D genetic map of the bacterial chromosome.
In this article, we sketch out a holistic methodology used for exploring how the genetic program is encoded in a 2-D genetic map of a bacterial chromosome. We argue that the major problem resides in the conceptual integration of the two logically distinct types of information encoded in the chiral double-helical DNA polymer. This integration is accomplished by mapping the genetic function on the genomic sequence organisation and therefore is potentially applicable to any chromosome. The vast generalisation achieved by this approach necessarily ignores exquisite details, yet it is fundamental in providing comprehensive methodology for exploring the role of the DNA sequence organisation in harnessing genetic information and sustaining biological order.
School of Engineering and Science, Jacobs University Bremen, Bremen, Germany.
Georgi
G
Muskhelishvili
Andrew
A
Travers
D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D002876:Chromosomes, Bacterial / Q000378:metabolism* / Q000648:ultrastructure*; D026942:DNA Topoisomerases / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism* / Q000648:ultrastructure; D004278:DNA, Superhelical / Q000378:metabolism / Q000648:ultrastructure; D046911:Macromolecular Substances / Q000378:metabolism* / Q000648:ultrastructure*; D062211:Spatio-Temporal Analysis
D004269:DNA, Bacterial; D004278:DNA, Superhelical; D046911:Macromolecular Substances; D026942:DNA Topoisomerases