[Human dendritic cells in allergic asthma and rhinitis].
The role of dendritic cells (DC) in the pathogenesis of allergic asthma and rhinitis has been highlighted for 15 years. In this review, we summarize key findings concerning DC function in airway allergy and focus on studies performed in human. DC coming from allergic patients have specific characteristics, including significant expression of high affinity receptor for IgE as well as a propensity for Th2 responses induction following priming with allergen and/or epithelial cytokines. Mechanistic data concerning this DC dysfunction in asthma also provide perspectives for innovating therapies.
Institut de recherche expérimentale et clinique, Université catholique de Louvain, Walloon institute for excellence in lifesciences and biotechnology (WELBIO), avenue Hippocrate 54, boîte 1.54.04, 1200 Bruxelles, Belgique.
Antoine
A
Froidure
Institut de recherche expérimentale et clinique, Université catholique de Louvain, Walloon institute for excellence in lifesciences and biotechnology (WELBIO), avenue Hippocrate 54, boîte 1.54.04, 1200 Bruxelles, Belgique - Cliniques universitaires Saint-Luc, service de pneumologie, Bruxelles, Belgique.
Charles
C
Pilette
D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use; D000485:Allergens / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017951:Antigen Presentation; D001249:Asthma / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D001980:Bronchi / Q000276:immunology / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication; D060833:Cellular Microenvironment; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology*; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D051379:Mice; D018448:Models, Immunological; D058990:Molecular Targeted Therapy; D017455:Receptors, IgE / Q000276:immunology; D065631:Rhinitis, Allergic / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000305:Adrenal Cortex Hormones; D000485:Allergens; D018926:Anti-Allergic Agents; D015815:Cell Adhesion Molecules; D016207:Cytokines; D017455:Receptors, IgE