A new indole-alkaloid and a new phenolic-glycoside with cytotoxic activity from Strychnos fendleri.
A new indole alkaloid strychnosinol (1) and a new phenolic-glycoside (2) were isolated from the bark and leaves of Strychnos fendleri Sprague & Sandwith, together with six known compounds reported for the first time in this species. The structures of these compounds were determined on the basis of spectroscopic data; mainly those obtained by using (1)H and (13)C NMR (1D and 2D) and mass spectrometry. Strychnosinol (1) and the phenolic glycoside (2) together with compounds 3-8 were evaluated for cytotoxicity against a panel of five tumour cell lines; IC50 values between 0.090 and 0.227 μM for the human tumour cell lines were observed for compound 2.
a Facultad de Farmacia, Universidad Central de Venezuela , Caracas , Venezuela.
Alírica I
AI
Suárez
a Facultad de Farmacia, Universidad Central de Venezuela , Caracas , Venezuela.
Monica
M
Mancebo
b Dipartimento di Chimica e Tecnologia delle Sostanze Biologicamente Attive , Università di Roma , Roma , Italy.
Franco
F
Delle Monache
c Facultad de Medicina, Universidad Central de Venezuela , Caracas , Venezuela.
María M
MM
Tirri
d IBE, Facultad de Ciencias, Universidad Central de Venezuela , Caracas , Venezuela.
Felipe
F
Sojo
d IBE, Facultad de Ciencias, Universidad Central de Venezuela , Caracas , Venezuela.
Francisco
F
Arvelo
a Facultad de Farmacia, Universidad Central de Venezuela , Caracas , Venezuela.
Stephen
S
Tillett
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D031451:Strychnos / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D007211:Indoles; D010636:Phenols; D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue
Strychnos fendleri; cytotoxicity; phenolic glycoside; strychnosinol