Plasma osteoprotegerin concentrations in type 1 diabetic patients with albuminuria.
BACKGROUND
Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicate that OPG is also associated with endothelial dysfunction in diabetes.


OBJECTIVE
To investigate the relationship between plasma OPG levels and urinary albumin excretion (UAE) in type 1 diabetes.


METHODS
A total of 80 type 1 diabetic subjects and 40 control subjects were enrolled. Diabetic subjects were divided into a normoalbuminuric group and a microalbuminuric group according to urinary albumin excretion rate (UAER). Plasma OPG level was measured by enzyme-linked immunoassay.


RESULTS
The plasma OPG levels were significantly elevated in patients with microalbuminuria (176.39±25.05pg/ml) compared with patients with normoalbuminuria (154.73±16.66pg/ml) and control subjects (44.76±8.7pg/ml). The plasma OPG level had a positive correlation with patients' age, duration of disease, HbA1C and UAER.


CONCLUSIONS
Plasma OPG levels are significantly associated with UAE in patients with type 1 diabetes. These findings may support the concept that elevated plasma OPG may be associated with diabetic angiopathy.
Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt.
Mona Hussein
MH
Elsamahy
Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt. Electronic address: dr_yasmi@yahoo.com.
Yasmine Ibrahim
YI
Elhenawy
Division of Pediatric Diabetes, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Egypt.
Marwa Magdy
MM
Nawar
D000293:Adolescent; D000419:Albuminuria / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications* / Q000652:urine; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D053244:Osteoprotegerin / Q000097:blood*; D012720:Severity of Illness Index
D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human
Angiopathy; Diabetic nephropathy; Osteoprotegerin; Type 1 Diabetes; Urinary albumin excretion