Transition-metal-free direct anti-carboboration of alkynes with boronic acids to produce alkenylheteroarenes.
The transition-metal-free intermolecular direct 1,2-carboboration reaction of heteroarylacetylenes using boronic acids as reagents is achieved by utilizing tartaric acid as promoter. The reaction proceeds with excellent regioselectivity and anti stereoselectivity to afford boroxole frameworks. The resulting compounds are of use for the stereoselective preparation of polysubstituted alkenylheteroarenes.
Instituto Pluridisciplinar, Universidad Complutense de Madrid, Campus de Excelencia Internactional Moncloa, Paseo de Juan XXIII, 1, 28040 Madrid, Spain.
Silvia
S
Roscales
Instituto Pluridisciplinar, Universidad Complutense de Madrid, Campus de Excelencia Internactional Moncloa, Paseo de Juan XXIII, 1, 28040 Madrid, Spain.
Aurelio G
AG
Csákÿ