Association of the apolipoprotein E 2 allele with concurrent occurrence of endometrial hyperplasia and endometrial carcinoma.
Genes encoding proteins with antioxidant properties may influence susceptibility to endometrial hyperplasia (EH) and endometrial carcinoma (ECa). Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n = 1110) were genotyped for five polymorphic variants in the genes involved in metabolism of lipoproteins (APOE Cys112Arg and Arg158Cys), iron (HFE Cys282Tyr and His63Asp), and catecholamines (COMT Val158Met). Patients and controls were matched by ethnicity (all Caucasians), age, body mass index (BMI), and incidence of hypertension and diabetes. The frequency of the APOE E 2 allele (158Cys) was higher in patients with EH + ECa than in controls (P = 0.0012, P(Bonferroni) = 0.018, OR = 2.58, 95% CI 1.49-4.45). The APOE E 4 allele (112Arg) was more frequently found in patients with EH than in controls and HFE minor allele G (63Asp) had a protective effect in the ECa group, though these results appeared to be nonsignificant after correction for multiple comparisons. The results of the study indicate that E 2 allele might be associated with concurrent occurrence of EH and ECa.
A. Cyb Scientific Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, 10 Zhukov Street, Obninsk, Kaluga Region 249036, Russia ; Federal State Budget Institution of Sciences Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilova Street, Moscow 119334, Russia.
Tatiana I
TI
Ivanova
A. Cyb Scientific Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, 10 Zhukov Street, Obninsk, Kaluga Region 249036, Russia.
Ludmila I
LI
Krikunova
A. Cyb Scientific Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, 10 Zhukov Street, Obninsk, Kaluga Region 249036, Russia.
Nikolay I
NI
Ryabchenko
A. Cyb Scientific Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, 10 Zhukov Street, Obninsk, Kaluga Region 249036, Russia.
Liana S
LS
Mkrtchyan
A. Cyb Scientific Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the Russian Federation, 10 Zhukov Street, Obninsk, Kaluga Region 249036, Russia.
Vera A
VA
Khorokhorina
Federal State Budget Institution of Sciences N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, 3 Gubkin Street, Moscow 117971, Russia ; Federal Research Center of Pediatric Hematology, Oncology and Immunology Named after Dmitry Rogachev, The Russian Ministry of Health and Social Development, 1 Samora Machel Street, Moscow 117198, Russia.
Lyubov E
LE
Salnikova
D000368:Aged; D000483:Alleles; D053329:Apolipoprotein E2 / Q000235:genetics*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D004714:Endometrial Hyperplasia / Q000235:genetics / Q000473:pathology; D016889:Endometrial Neoplasms / Q000235:genetics / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008565:Membrane Proteins / Q000235:genetics; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
D053329:Apolipoprotein E2; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins