Role of COX-2/mPGES-1/prostaglandin E2 cascade in kidney injury.
COX-2/mPGES-1/PGE2 cascade plays critical roles in modulating many physiological and pathological actions in different organs. In the kidney, this cascade is of high importance in regulating fluid metabolism, blood pressure, and renal hemodynamics. Under some disease conditions, this cascade displays various actions in response to the different pathological insults. In the present review, the roles of this cascade in the pathogenesis of kidney injuries including diabetic and nondiabetic kidney diseases and acute kidney injuries were introduced and discussed. The new insights from this review not only increase the understanding of the pathological role of the COX-2/mPGES-1/PGE2 pathway in kidney injuries, but also shed new light on the innovation of the strategies for the treatment of kidney diseases.
Nanjing Key Laboratory of Pediatrics, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China ; Department of Nephrology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Zhanjun
Z
Jia
Nanjing Key Laboratory of Pediatrics, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China ; Department of Nephrology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Yue
Y
Zhang
Nanjing Key Laboratory of Pediatrics, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China ; Department of Nephrology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Guixia
G
Ding
Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Kristina Marie
KM
Heiney
Nanjing Key Laboratory of Pediatrics, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China ; Department of Nephrology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Songming
S
Huang
Nanjing Key Laboratory of Pediatrics, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China ; Department of Nephrology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.
Aihua
A
Zhang
D000818:Animals; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D015232:Dinoprostone / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D000071876:Prostaglandin-E Synthases
D051546:Cyclooxygenase 2; D019746:Intramolecular Oxidoreductases; C000605862:PTGES protein, human; D000071876:Prostaglandin-E Synthases; D015232:Dinoprostone