Left-right asymmetry: cilia and calcium revisited.
Leftward flow generated by motile cilia is known to underlie left-right asymmetry in vertebrate embryos. A new study now links intraciliary calcium oscillations to cilia motility and the downstream nodal signaling cascade that drives left-sided development.
University of Hohenheim, Institute of Zoology, Garbenstrasse 30, 70593 Stuttgart, Germany. Electronic address: martin.blum@uni-hohenheim.de.
Martin
M
Blum
University of Hohenheim, Institute of Zoology, Garbenstrasse 30, 70593 Stuttgart, Germany.
Philipp
P
Vick
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D002923:Cilia / Q000378:metabolism*; D059446:Heterotaxy Syndrome / Q000196:embryology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D015027:Zebrafish / Q000196:embryology*