Concepts in solid tumor evolution.
Evolutionary mechanisms in cancer progression give tumors their individuality. Cancer evolution is different from organismal evolution, however, and we discuss where concepts from evolutionary genetics are useful or limited in facilitating an understanding of cancer. Based on these concepts we construct and apply the simplest plausible model of tumor growth and progression. Simulations using this simple model illustrate the importance of stochastic events early in tumorigenesis, highlight the dominance of exponential growth over linear growth and differentiation, and explain the clonal substructure of tumors.
Departments of Pathology and of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: arend@stanford.edu.
Arend
A
Sidow
Departments of Pathology and of Genetics, Stanford University, Stanford, CA 94305, USA.
Noah
N
Spies
D000818:Animals; D002454:Cell Differentiation; D018450:Disease Progression; D018740:Genetic Heterogeneity; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology*