Effects of Selenium Presence in Mycelia of Ganoderma species (Higher Basidiomycetes) on Their Medicinal Properties.
This study aimed to research the antifungal, antioxidant, and cytotoxic potential of Ganoderma applanatum and Ganoderma lucidum mycelial extracts as well as the possible effect of Se enrichment on these activities. Both Se-enriched and nonenriched extracts of G. applanatum and G. lucidum showed fungi static activity, while a fungicidal effect was not noted. The extracts exhibited significant 1,1-diphenyl-2-picryl-hydrazil radical scavenging capacity, while the effect of Se on this potential was stimulatory in G. applanatum (1.3%-33.9% without Se and 3.1%-67.1% in Se enrichment) and inhibitory in G. lucidum (1.4%-71.6% and 1.3%-48.6% without and with Se, respectively). Only phenols in G. applanatum and phenols and flavonoids in G. lucidum were holders of antioxidant activity. Cytotoxic activity against both HeLa and LS174 cell lines was very low in comparison with cis-diamminedichloroplatinum.
University of Belgrade Faculty of Biology, Belgrade, Serbia.
Ivan
I
Milovanović
Institute of Botany, Faculty of Biology, University of Belgrade, Serbia.
Mirjana
M
Stajić
Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.
Tatjana
T
Stanojković
University of Belgrade Faculty of Biology, Belgrade, Serbia.
Aleksandar
A
Knežević
Institute of Botany, Faculty of Biology, University of Belgrade, Takovska 43, 11000 Belgrade, Serbia.
Jelena
J
Vukojević
D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology; D032902:Ganoderma / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D025282:Mycelium / Q000737:chemistry* / Q000378:metabolism; D010636:Phenols / Q000032:analysis / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D012643:Selenium / Q000032:analysis* / Q000494:pharmacology
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D012643:Selenium