H2S regulation of nitric oxide metabolism.
Nitric oxide (NO) and hydrogen sulfide (H2S) are two major gaseous signaling molecules that regulate diverse physiological functions. Recent publications indicate the regulatory role of H2S on NO metabolism. In this chapter, we discuss the latest findings on H2S-NO interactions through formation of novel chemical derivatives and experimental approaches to study these adducts. This chapter also addresses potential H2S interference on various NO detection techniques, along with precautions for analyzing biological samples from various sources. This information will facilitate critical evaluation and clearer insight into H2S regulation of NO signaling and its influence on various physiological functions.
Department of Pathology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. Electronic address: gkkolluru@gmail.com.
Gopi K
GK
Kolluru
Department of Pathology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
Shuai
S
Yuan
Department of Pathology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA.
Xinggui
X
Shen
Department of Pathology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. Electronic address: ckevil@LSUHSC.edu.
Christopher G
CG
Kevil
D000818:Animals; D015153:Blotting, Western; D002478:Cells, Cultured; D005456:Fluorescent Dyes / Q000737:chemistry; D015870:Gene Expression; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D008163:Luminescent Measurements / Q000592:standards; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D012015:Reference Standards; D015398:Signal Transduction
D005456:Fluorescent Dyes; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D006862:Hydrogen Sulfide
Biochemistry; Nitric oxide synthase; Nitrite; Oxidation; Peroxynitrite; Reduction; Sulfide