[Application of dexmedetomidine combined with propofol in patients undergoing painless colonoscopy for colonic polyps resection under Narcotrend monitoring].
OBJECTIVE
This clinical study was conducted to investigate the effects of dexmedetomidine (DEX) combined with propofol on vital signs and anaesthetic depth in patients.


METHODS
Ninety patients with ASA 1-2 requiring painless colonoscopy for colonic polyps resection were randomized to receive DEX 0.3 micro;g/kg (group D, n=45) followed by propofol 1 mg/kg or propofol 2 mg/kg (group C, n=45), and according to the body activity and operation time, additional doses of propofol (0.2-0.5 mg/kg) were given. The full recovery time, operation time, consumed dose of propofol, mean arterial pressure (MAP), heart rate (HR), hemoglobin oxygen saturation levels(SPO₂) and NTI were recorded.


RESULTS
The SPO₂recover time and the consumed dose of propofol in group D were decreased compared to those in group C (P<0.01). The rate of the body activity in group D was lower than that in group C (P<0.05). The NTI in group C was lower than that in group D (P<0.05). The HR and MAP were similar in both groups.


CONCLUSIONS
Under Narcotrend monitoring, the value of DEX combined with low dose of propofol in colonoscopy for colonic polyps resection is to reach more reasonable depth of anesthesia to reduce adverse responses and the dose of propofol.
Department of Anesthesiology, ZHOU Guobin,WANG zhipeng WANG Yan, Guangdong General Hospital , Guangzhou 510080, China.E-mail: 5413jjq@sina.com.
Jinquan
J
Ji
Gang
G
Wang
Ke
K
Sun
Guobin
G
Zhou
Zhipeng
Z
Wang
Yan
Y
Wang
D000758:Anesthesia / Q000379:methods*; D062186:Arterial Pressure; D003111:Colonic Polyps / Q000601:surgery*; D003113:Colonoscopy; D020927:Dexmedetomidine; D006339:Heart Rate; D006801:Humans; D015742:Propofol
D020927:Dexmedetomidine; D015742:Propofol