Methylmercury in the breast milk of Japanese mothers and lactational exposure of their infants.
The human fetus is known to be exposed to methylmercury (MeHg), but little is known about the risk of infant exposure via breast milk. To evaluate the lactational exposure to MeHg via breast milk in Japanese infants, the levels of total mercury (THg) and MeHg were determined in breast milk and maternal blood using samples from a birth cohort study at the Tohoku Study of Child Development. Maternal blood and breast milk were collected one day postpartum and one month after delivery, respectively. The median THg (and MeHg) concentrations in maternal RBCs, plasma and breast milk were 17.8 ng g(-1) (17.8 ng g(-1)), 1.51 ng g(-1) (1.33 ng g(-1)) and 0.81 ng g(-1) (0.45 ng g(-1)), respectively (n=27). The median percentage of MeHg in THg was 54% in breast milk. Breast milk contained substantial amounts of MeHg, which was strongly associated with the internal accumulation of MeHg and the lipid content of the milk (r=0.684). The range of lipid contents in milk varied widely from 0.50 to 6.60 g/100 g of milk, with a median of 3.60 g/100 g. The median (range) weekly average intake of MeHg via breast milk was estimated to be 0.63 μg kg(-1) (0.08-1.68 μg kg(-1)) BW/week. Because the MeHg and lipid contents in milk substantially fluctuate, an investigation of the variations of MeHg and lipid content in breast milk may be required for a more precise risk assessment.
Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Research Fellow of the Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan. Electronic address: miyuki@m.tohoku.ac.jp.
Miyuki
M
Iwai-Shimada
Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Hiroshi
H
Satoh
Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Kunihiko
K
Nakai
Department of Development and Environmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Nozomi
N
Tatsuta
Environmental Health Sciences, Akita University Graduate School of Medicine, Akita, Japan.
Katsuyuki
K
Murata
International Mercury Laboratory Inc., Minamata, Kumamoto, Japan.
Hirokatsu
H
Akagi
D015331:Cohort Studies; D004784:Environmental Monitoring / Q000379:methods / Q000706:statistics & numerical data*; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D006801:Humans; D007564:Japan; D018811:Maternal Exposure / Q000706:statistics & numerical data*; D008767:Methylmercury Compounds / Q000032:analysis* / Q000097:blood; D008895:Milk, Human / Q000737:chemistry*; D018570:Risk Assessment / Q000379:methods
D008767:Methylmercury Compounds
Inorganic mercury; Lactational exposure; Mercury; Methylmercury; Milk