A lack of experience-dependent plasticity after more than a decade of recovered sight.
In 2000, monocular vision was restored to M. M., who had been blind between the ages of 3 and 46 years. Tests carried out over 2 years following the surgery revealed impairments of 3-D form, object, and face processing and an absence of object- and face-selective blood-oxygen-level-dependent responses in ventral visual cortex. In the present research, we reexamined M. M. to test for experience-dependent recovery of visual function. Behaviorally, M. M. remains impaired in 3-D form, object, and face processing. Accordingly, we found little to no evidence of the category-selective organization within ventral visual cortex typically associated with face, body, scene, or object processing. We did observe remarkably normal object selectivity within lateral occipital cortex, consistent with M. M.'s previously reported shape-discrimination performance. Together, these findings provide little evidence for recovery of high-level visual function after more than a decade of visual experience in adulthood.
Department of Psychology, University of Washington.
Elizabeth
E
Huber
Department of Psychology, University of Washington jwebst@uw.edu.
Jason M
JM
Webster
Department of Cognitive Sciences, University of California, Irvine.
Alyssa A
AA
Brewer
Department of Psychology, University of California, San Diego.
Donald I A
DI
MacLeod
Department of Psychology, Stanford University.
Brian A
BA
Wandell
Department of Psychology, University of Washington.
Geoffrey M
GM
Boynton
Department of Psychology, University of York.
Alex R
AR
Wade
Department of Psychology, University of Washington.
Ione
I
Fine
D000328:Adult; D001766:Blindness / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology; D015349:Vision, Monocular / Q000502:physiology*; D014793:Visual Cortex / Q000503:physiopathology*
face perception; neuroimaging; object recognition; temporal lobe; vision