Placental expression of adenosine A(2A) receptor and hypoxia inducible factor-1 alpha in early pregnancy, term and pre-eclamptic pregnancies: interactions with placental renin-angiotensin system.
Hypoxia-inducible factors (HIFs), adenosine and tissue renin-angiotensin-system (RAS) promote angiogenesis and vascularisation. We investigated the temporal expression placental adenosine A2AR receptor and HIF-1α in early pregnancy and at delivery in normotensive (NT) and pre-eclamptic (PE) women. Results were compared to our previously reported angiotensin receptor data. Expression of A2AR and HIF-1α was highest at ≤10 weeks, positively correlated through pregnancy and was higher in PE than NT at delivery. The A2AR associated with the AT4R only in early pregnancy. We suggest adenosine and RAS may interact to promote placentation with a potential adaptation to poor placental perfusion in PE.
Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, NG5 1PB, UK. Electronic address: Lesia.kurlak@nottingham.ac.uk.
L O
LO
Kurlak
School of Veterinary Medicine & Science, Faculty of Medicine and Health Science, University of Nottingham, LE12 5RD, UK.
P J
PJ
Williams
Institute of Cellular Medicine, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
J N
JN
Bulmer
Department of Obstetrics & Gynaecology, School of Medicine, University of Nottingham, NG5 1PB, UK.
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Broughton Pipkin
Division of Hypertension, Department of Nephrology, Hypertension and Clinical Pharmacology, University of Bern, Berne CH-3010, Switzerland.
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HD
Mistry
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism*; D043705:Receptor, Adenosine A2A / Q000378:metabolism*; D011945:Receptors, Angiotensin / Q000378:metabolism; D012084:Renin-Angiotensin System
C090830:AT4 receptor; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D043705:Receptor, Adenosine A2A; D011945:Receptors, Angiotensin
Early pregnancy; HIF-1α: angiotensin receptors; Placental A2AR; Pre-eclampsia