Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy.
Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.
Program in Systems Biology, Program in Molecular Medicine, and Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: michael.lee@umassmed.edu.
Michael J
MJ
Lee
D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D016899:Interferon-beta / Q000494:pharmacology*; D020935:MAP Kinase Signaling System / Q000187:drug effects*
D016898:Interferon-alpha; D016899:Interferon-beta