Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen.
A 36-year-old Japanese woman took over-the-counter (OTC) medication for headaches for 20 days. Subsequently, five days after discontinuing the medication, a skin rash developed over the patient's upper and lower limbs and face, in addition to a fever, brown urine and serious liver dysfunction. Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made. The patient's symptoms and liver function tests returned to normal following treatment with systemic steroids.
Departments of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan.
Takao
T
Watanabe
Masanori
M
Abe
Fujimasa
F
Tada
Kanako
K
Aritomo
Hironori
H
Ochi
Yohei
Y
Koizumi
Yoshio
Y
Tokumoto
Masashi
M
Hirooka
Teru
T
Kumagi
Yoshio
Y
Ikeda
Bunzo
B
Matsuura
Yoichi
Y
Hiasa
D000328:Adult; D044466:Asian People; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects* / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
D013256:Steroids; D007052:Ibuprofen