[Evaluation of the pharmaceutical stability of polaprezinc/sodium alginate gargle solution containing lidocaine].
OBJECTIVE
A gargle solution(L-P/AG)for the treatment of painful stomatitis was prepared by adding lidocaine to a polaprezinc/sodium alginate gargle solution(P/AG), and its pharmaceutical stability was evaluated.


METHODS
L-P/AG was stored at 5, 25, and 40°C. The strengths of polaprezinc and lidocaine were determined. The viscosity and pH of L-P/AG were also determined, and its appearance was evaluated.


RESULTS
When stored at 5 or 25°C in a dark place, L-P/AG showed neither reduction in the strength of either drug nor did it show a change in the viscosity, pH, or appearance. When stored exposed to light at 40°C, L-P/AG showed reductions in the strength of both drugs, as well as in viscosity and pH; furthermore, a change in appearance was noted.


CONCLUSIONS
L-P/AG prepared for the treatment of painful stomatitis remains pharmaceutically stable for 28 days when stored at 25°C in a dark place.
Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University.
Michiaki
M
Myotoku
Tatsuto
T
Matsuyama
Ryosuke
R
Umetani
Sayaka
S
Nakamura
Takashi
T
Oka
Naoko
N
Kitade
Yoko
Y
Urashima
Yoshihiko
Y
Hirotani
D000464:Alginates / Q000737:chemistry*; D002336:Carnosine / Q000031:analogs & derivatives* / Q000737:chemistry; D004355:Drug Stability; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008012:Lidocaine / Q000737:chemistry*; D009910:Oral Hygiene; D009942:Organometallic Compounds / Q000737:chemistry*; D019999:Pharmaceutical Solutions / Q000737:chemistry; D013696:Temperature; D014783:Viscosity; D017967:Zinc Compounds / Q000737:chemistry
D000464:Alginates; D006603:Hexuronic Acids; D009942:Organometallic Compounds; D019999:Pharmaceutical Solutions; D017967:Zinc Compounds; C061957:polaprezinc; D020723:Glucuronic Acid; D002336:Carnosine; D008012:Lidocaine