Efficient asymmetric transfer hydrogenation of ketones in ethanol with chiral iridium complexes of spiroPAP ligands as catalysts.
Highly efficient iridium catalyzed asymmetric transfer hydrogenation of simple ketones with ethanol as a hydrogen donor has been developed. By using chiral spiro iridium catalysts (S)- a series of alkyl aryl ketones were hydrogenated to chiral alcohols with up to 98% ee.
State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China. jhxie@nankai.edu.cn qlzhou@nankai.edu.cn.
Wei-Peng
WP
Liu
Ming-Lei
ML
Yuan
Xiao-Hui
XH
Yang
Ke
K
Li
Jian-Hua
JH
Xie
Qi-Lin
QL
Zhou
D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*
D000438:Alcohols; D007659:Ketones; D008024:Ligands; D009942:Organometallic Compounds; D013141:Spiro Compounds; D007495:Iridium