A hypoxia efficient imidazole-based Ru(II) arene anticancer agent resistant to deactivation by glutathione.
A slow hydrolyzing imidazole-based Ru(II)-arene complex [(L)Ru(II)(η(6)-p-cym)(Cl)](PF6) (1) with excellent stability in the extracellular chloride concentration shows better activity under hypoxia and strong resistance to glutathione (GSH) in vitro under hypoxic conditions. 1 arrests the cell cycle in sub G1 and G2/M phases and leads to apoptosis.
Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur campus, Mohanpur-741246, India. a.mukherjee@iiserkol.ac.in.
Kallol
K
Purkait
Subhendu
S
Karmakar
Sudipta
S
Bhattacharyya
Saptarshi
S
Chatterjee
Suman Kr
SK
Dey
Arindam
A
Mukherjee
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D015687:Cell Hypoxia; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007093:Imidazoles; C029899:imidazole; D012428:Ruthenium; D005978:Glutathione