Impacts of early viability selection on management of inbreeding and genetic diversity in conservation.
Maintaining genetic diversity is a crucial goal of intensive management of threatened species, particularly for those populations that act as sources for translocation or re-introduction programmes. Most captive genetic management is based on pedigrees and a neutral theory of inheritance, an assumption that may be violated by selective forces operating in captivity. Here, we explore the conservation consequences of early viability selection: differential offspring survival that occurs prior to management or research observations, such as embryo deaths in utero. If early viability selection produces genotypic deviations from Mendelian predictions, it may undermine management strategies intended to minimize inbreeding and maintain genetic diversity. We use empirical examples to demonstrate that straightforward approaches, such as comparing litter sizes of inbred vs. noninbred breeding pairs, can be used to test whether early viability selection likely impacts estimates of inbreeding depression. We also show that comparing multilocus genotype data to pedigree predictions can reveal whether early viability selection drives systematic biases in genetic diversity, patterns that would not be detected using pedigree-based statistics alone. More sophisticated analysis combining genomewide molecular data with pedigree information will enable conservation scientists to test whether early viability selection drives deviations from neutrality across wide stretches of the genome, revealing whether this form of selection biases the pedigree-based statistics and inference upon which intensive management is based.
Faculty of Veterinary Science, University of Sydney, Sydney, NSW, 2006, Australia; San Diego Zoo Global, PO Box 120551, San Diego, CA, 92112, USA.
Catherine E
CE
Grueber
Carolyn J
CJ
Hogg
Jamie A
JA
Ivy
Katherine
K
Belov
D000818:Animals; D003247:Conservation of Natural Resources / Q000379:methods*; D056727:Endangered Species; D056084:Genetic Fitness; D014644:Genetic Variation; D005828:Genetics, Population; D007178:Inbreeding; D008098:Litter Size; D008957:Models, Genetic; D010375:Pedigree; D012641:Selection, Genetic
adaptation; captive breeding; embryo losses; ex situ management; heterozygosity; pedigrees