Interleukin-10 gene promoter polymorphism and risk of liver cirrhosis.
We conducted a hospital-based case-control study to assess the association between IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G polymorphisms and the risk of liver cirrhosis in a Chinese population. This 1:1-matched case-control study included 192 patients from the Chinese PLA General Hospital. Genotypes of IL-10-592 A/C, IL-10-819 C/T, and IL-10-1082 A/G were detected by polymerase chain reaction amplification-restriction fragment length polymorphism analysis. Conditional regression analysis showed that individuals carrying the IL-10-1082 G allele had an only slightly increased risk of liver cirrhosis, with an adjusted odds ratio (95% confidence interval) of 2.14 (0.97-1.68). However, we did not identify a significant association between polymorphisms in IL-10-592 A/C and IL-10-819 C/T and the risk of liver cirrhosis. These findings may provide important clues for future studies of early detection screening of liver cirrhosis.
Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
Y
Y
Liu
Department of Hepatobiliary Surgery, Zhangqiu People's Hospital, Affiliated Hospital of Jining Medical University, Jinan, China.
M C
MC
Yu
Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
A Q
AQ
Zhang
Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
Y B
YB
Wang
Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China.
K
K
Jiang
Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing, China zhaop92622@163.com.
J H
JH
Dong
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006760:Hospitalization; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008103:Liver Cirrhosis / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D017422:Sequence Analysis, DNA
C508609:IL10 protein, human; D016753:Interleukin-10