The Expression and Significance of CXCR5 and MMP-13 in Colorectal Cancer.
The objective of the study is to investigate the CXCR5 and MMP-13 expression in colorectal cancer and explore its correlation between the clinicopathological characteristics and prognosis. The expressions of CXCR5 and MMP-13 proteins in 236 paired specimens of colorectal cancer and incisal edge normal tissues as well as 62 samples of colorectal adenoma tissues were analyzed by immunohistochemistry. The CXCR5 and MMP-13 positive expression rate in colorectal cancer tissues was 43.6 and 80.5 %, respectively. Both rates were higher than those in the incisal edge healthy intestinal mucosal tissues (4.2 and 13.1 %) and colorectal adenoma tissues (24.2 and 64.5 %), P < 0. 05 in both cases. The expressions of the CXCR5 and MMP-13 proteins were positively related to the lymph node and distal metastasis, tumor stage and relapse, P < 0. 05. The expression of the CXCR5 protein was positively related to MMP-13, P < 0. 05. The median and overall survival in the patients with positive CXCR5 and MMP-13 expression were significantly shorter than those with negative expression: median survival, 20.5 months (CXCR5 +) versus 30.8 months (CXCR5 -), 20.3 months (MMP-13 +) versus 24.6 months; overall survival, 26.5 months (CXCR5 +) versus 47.5 months (CXCR5 -), 22.7 months (MMP-13 +) versus 29.3 months. The expression of CXCR5 and MMP-13 could promote the pathogenesis, development, metastasis, and relapse of colorectal cancer. It could also serve as a valuable indicator for the prediction of metastasis and relapse of colorectal cancer.
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Qin
Q
Yan
Wuxi Oncology Institute, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Yin
Y
Yuan
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Liu
L
Yankui
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Feng
F
Jingjie
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Jin
J
Linfang
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China.
Pu
P
Yong
Department of Oncology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China. 597559460@qq.com.
Hua
H
Dong
Department of Pathology, The Affiliated Hospital of Jiangnan University, Wu Xi NO 4 Hospital, Wuxi, 214062, China. qixiaowei97@163.com.
Qi
Q
Xiaowei
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D054380:Receptors, CXCR5 / Q000235:genetics / Q000378:metabolism*
D014408:Biomarkers, Tumor; C095085:CXCR5 protein, human; D054380:Receptors, CXCR5; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13
CXCR5; Colorectal cancer; Matrix metalloproteinase-13; Metastasis; Prognosis