Explicit memory creation during sleep demonstrates a causal role of place cells in navigation.
Hippocampal place cells assemblies are believed to support the cognitive map, and their reactivations during sleep are thought to be involved in spatial memory consolidation. By triggering intracranial rewarding stimulations by place cell spikes during sleep, we induced an explicit memory trace, leading to a goal-directed behavior toward the place field. This demonstrates that place cells' activity during sleep still conveys relevant spatial information and that this activity is functionally significant for navigation.
1] Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France. [2] Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246; INSERM, UMR-S 1130; Sorbonne Universités, University Pierre and Marie Curie, Paris, France.
Gaetan
G
de Lavilléon
1] Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France. [2] Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246; INSERM, UMR-S 1130; Sorbonne Universités, University Pierre and Marie Curie, Paris, France.
Marie Masako
MM
Lacroix
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246; INSERM, UMR-S 1130; Sorbonne Universités, University Pierre and Marie Curie, Paris, France.
Laure
L
Rondi-Reig
1] Team Memory, Oscillations and Brain States (MOBs), Brain Plasticity Unit, CNRS UMR 8249, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris, Paris, France. [2] Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246; INSERM, UMR-S 1130; Sorbonne Universités, University Pierre and Marie Curie, Paris, France.
Karim
K
Benchenane
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D006040:Goals; D006801:Humans; D008297:Male; D008474:Medial Forebrain Bundle / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018408:Patch-Clamp Techniques; D012201:Reward; D012890:Sleep / Q000502:physiology*; D065852:Spatial Memory / Q000502:physiology*; D065854:Spatial Navigation / Q000502:physiology*