Surgical management of pancreatic cancer--pancreaticoduodenectomy.
Pancreaticoduodenectomy, the Whipple resection, is a complex operation that is commonly performed for patients with pancreatic ductal adenocarcinoma and other malignant or benign lesions in the head of the pancreas. It can be done with low morbidity and mortality rates, particularly when performed at high-volume hospitals and by high-volume surgeons. While it has been conventionally reserved for patients with early-stage malignant disease, it is being used increasingly for patients with locally extensive tumors who have undergone neoadjuvant therapy and downstaging. This article summarizes the role of pancreaticoduodenectomy for the treatment of patients with pancreatic cancer. It highlights the surgical staging of disease, the technical aspects of the operation and perioperative care, and the oncologic outcome.
Departments of Surgery, Division of General Surgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA. Electronic address: tdonahue@mednet.ucla.edu.
Timothy R
TR
Donahue
Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA.
Howard A
HA
Reber
D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D019468:Disease Management; D006801:Humans; D009367:Neoplasm Staging; D010179:Pancreas / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D016896:Treatment Outcome