A water-soluble carboxylic-functionalized chemosensor for detecting Al(3+) in aqueous media and living cells: Experimental and theoretical studies.
A new water-soluble carboxylic-functionalized chemosensor 1 was designed and synthesized. 1 exhibited the selective fluorescence enhancement toward aluminum ions with a 1:1 complexation stoichiometry in aqueous solution. The detection limit (24nM) of 1 for Al(3+) is about two order lower than the WHO guideline (7.41μM) for the drinking water. 1 was successfully applied to living cells and real samples for detecting Al(3+). Moreover, the sensing mechanism originated from the inhibited excited-state intramolecular proton transfer (ESIPT) process and the chelation-enhanced fluorescence (CHEF) effect, as supported by theoretical calculations.
Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea.
Jae
J
Jun Lee
Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea.
Gyeong
G
Jin Park
Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea.
Yong
Y
Sung Kim
Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea.
Sun
S
Young Lee
Department of Chemical and Biomolecular Engineering, and Convergence Program of Biomedical Engineering and Biomaterials, Seoul National University of Science & Technology, Seoul 139-743, Korea.
Hyun
H
Ji Lee
Department of Chemical and Biomolecular Engineering, and Convergence Program of Biomedical Engineering and Biomaterials, Seoul National University of Science & Technology, Seoul 139-743, Korea.
Insup
I
Noh
Department of Fine Chemistry and Department of Interdisciplinary Bio IT Materials, Seoul National University of Science and Technology, Seoul 139-743, Korea. Electronic address: chealkim@seoultech.ac.kr.
Cheal
C
Kim
D000535:Aluminum / Q000032:analysis*; D002264:Carboxylic Acids / Q000737:chemistry; D002478:Cells, Cultured; D003198:Computer Simulation; D017076:Computer-Aided Design; D060766:Drinking Water / Q000032:analysis* / Q000737:chemistry; D004784:Environmental Monitoring / Q000295:instrumentation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005347:Fibroblasts / Q000737:chemistry*; D005470:Fluorometry / Q000295:instrumentation*; D006801:Humans; D008956:Models, Chemical; D012995:Solubility; D014867:Water / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*
D002264:Carboxylic Acids; D060766:Drinking Water; D014874:Water Pollutants, Chemical; D014867:Water; D000535:Aluminum
Aluminum; Bio-imaging; Carboxylic-functionalized; Theoretical calculations; Water-soluble