Fe₃O₄@ZnO core-shell nanocomposites for efficient and repetitive removal of low density lipoprotein in plasma and on blood vessel.
Low density lipoprotein (LDL)-apheresis therapy, which directly removes LDL from plasma by LDL-adsorbents in vitro is found to be clinically effective and safe to lower the LDL content in blood to prevent cardiovascular disease. Thus, developing excellent LDL adsorbents are becoming more and more attractive. Herein, functional Fe3O4@ZnO core-shell nanocomposites have been synthesized by a facile and eco-friendly two-step method. Not only do they possess high LDL adsorption (in PBS/plasma as well as on blood vessels) and favorable magnetic targeting ability but they can also be reused conveniently, which offer the Fe3O4@ZnO core-shell nanocomposites significant potential in the removal of LDL in vitro and in vivo.
Key Laboratory for Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, People's Republic of China. College of Materials and Chemical Engineering, Tongren University, Tongren 554300, People's Republic of China.
Xiao
X
Huang
Juan
J
Lu
Danyang
D
Yue
Yijuan
Y
Fan
Caixia
C
Yi
Xiaoying
X
Wang
Mengxue
M
Zhang
Jun
J
Pan
D001781:Blood Component Removal / Q000295:instrumentation* / Q000379:methods*; D001808:Blood Vessels / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry*; D060328:Magnetic Phenomena; D053761:Nanocomposites / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry* / Q000627:therapeutic use*
D008077:Lipoproteins, LDL