The human placental methylome.
This review provides an overview of the unique features of DNA methylation in the human placenta. We discuss the importance of understanding placental development, structure, and function in the interpretation of DNA methylation data. Examples are given of how DNA methylation is important in regulating placental-specific gene expression, including monoallelic expression and X-chromosome inactivation in the placenta. We also discuss studies of global DNA methylation changes in the context of placental pathology and environmental exposures.
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada Child & Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.
Wendy P
WP
Robinson
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada Child & Family Research Institute, Vancouver, British Columbia V5Z 4H4, Canada.
E Magda
EM
Price
D019175:DNA Methylation; D004781:Environmental Exposure; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D010920:Placenta / Q000033:anatomy & histology / Q000502:physiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics*