Combined medico-surgical strategy for invasive sino-orbito-cerebral breakthrough fungal infection with Hormographiella aspergillata in an acute leukaemia patient.
Hormographiella aspergillata is a rare causative agent of invasive filamentous breakthrough infection, mostly arising after echinocandin exposure. We report a neutropenic patient who developed a severe sino-orbito-cerebral H. aspergillata infection while receiving empirical caspofungin, successfully controlled by an aggressive strategy associating surgical debridement and combined high-dose regimen of antifungal drugs.
Service d'Hématologie 1G, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France.
M
M
Heiblig
V
V
Bozzoli
J
J
Saison
X
X
Thomas
D
D
De Croze
A
A
Traverse-Glehen
A
A
Cosmidis
C
C
Chidiac
T
T
Ferry
A
A
Alanio
A L
AL
Bienvenu
D
D
Dupont
S
S
Ducastelle-Lepretre
M
M
Michallet
F
F
Ader
D000363:Agaricales / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D000077336:Caspofungin; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D003131:Combined Modality Therapy; D003646:Debridement; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D055666:Lipopeptides; D008297:Male; D008969:Molecular Sequence Data; D009503:Neutropenia / Q000150:complications*; D055815:Young Adult
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
Hormographiella aspergillata; acute myeloid leukaemia; allogeneic haematopoietic stem cell transplantation; basidiomycosis