Aqueous microwave-assisted cross-coupling reactions applied to unprotected nucleosides.
Metal catalyzed cross-coupling reactions have been the preferred tools to access to modified nucleosides (on the C5-position of pyrimidines and on the C7- or C8-positions of purines). Our objective is to focus this mini-review on the Suzuki-Miyaura and on the Heck cross-couplings of nucleosides using microwave irradiations which is an alternative technology compatible with green chemistry and sustainable development.
Sorbonne Universités, Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, EA 4297 Transformations Intégrées de la Matière Renouvelable, Centre de Recherche Royallieu Compiégne, France.
Gwénaëlle
G
Hervé
Sorbonne Universités, Université de Technologie de Compiègne, Ecole Supérieure de Chimie Organique et Minérale, EA 4297 Transformations Intégrées de la Matière Renouvelable, Centre de Recherche Royallieu Compiégne, France ; Department of Chemistry, University of Hull Hull, England.
Christophe
C
Len
Heck; Suzuki-Miyaura; green chemistry; microwave; nucleoside; nucleotide; water