Telomerase expression in the glial scar of rats with spinal cord injury.
A rat model of spinal cord injury was established using the weight drop method. A cavity formed 14 days following spinal cord injury, and compact scar tissue formed by 56 days. Enzyme-linked immunosorbent assay and polymerase chain reaction enzyme-linked immunosorbent assay results demonstrated that glial fibrillary acidic protein and telomerase expression increased gradually after injury, peaked at 28 days, and then gradually decreased. Spearman rank correlation showed a positive correlation between glial fibrillary acidic protein expression and telomerase expression in the glial scar. These results suggest that telomerase promotes glial scar formation.
Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Mingkun
M
Yang
Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Weibin
W
Sheng
Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Tao
T
Xu
Department of Spinal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Kai
K
Huang
Department of Molecular Biology, Basic Medical College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China.
Yanjiao
Y
Wang
astrocytes; glial fibrillary acidic protein; glial scar; spinal cord injury; telomerase