Texture analysis as a tool to study the kinetics of wet agglomeration processes.
In this work wet granulation experiments were carried out in a planetary mixer with the aim to develop a novel analytical tool based on surface texture analysis. The evolution of a simple formulation (300g of microcrystalline cellulose with a solid binders pre-dispersed in water) was monitored from the very beginning up to the end point and information on the kinetics of granulation as well as on the effect of liquid binder amount were collected. Agreement between texture analysis and granules particle size distribution obtained by sieving analysis was always found. The method proved to be robust enough to easily monitor the process and its use for more refined analyses on the different rate processes occurring during granulation is also suggested.
APTLab - Advanced Particle Technology Laboratory, University of Padova, Department of Industrial Engineering, via Marzolo 9, 35131 Padova, Italy.
Silvia
S
Nalesso
PharmaTeG - Pharmaceutical Technology Group, University of Padova, Department of Pharmaceutical and Pharmacological Sciences, via Marzolo 5, 35131 Padova, Italy.
Carlo
C
Codemo
PharmaTeG - Pharmaceutical Technology Group, University of Padova, Department of Pharmaceutical and Pharmacological Sciences, via Marzolo 5, 35131 Padova, Italy.
Erica
E
Franceschinis
PharmaTeG - Pharmaceutical Technology Group, University of Padova, Department of Pharmaceutical and Pharmacological Sciences, via Marzolo 5, 35131 Padova, Italy.
Nicola
N
Realdon
LUNAM Université, IFSTTAR, site de Nantes, MAST/GPEM, Route de Bouaye CS4, 44344 Bouguenais, France.
Riccardo
R
Artoni
APTLab - Advanced Particle Technology Laboratory, University of Padova, Department of Industrial Engineering, via Marzolo 9, 35131 Padova, Italy. Electronic address: andrea.santomaso@unipd.it.
Andrea C
AC
Santomaso
D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004867:Equipment Design; D007700:Kinetics; D015233:Models, Statistical; D010316:Particle Size; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D011208:Powders; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D014783:Viscosity; D014867:Water / Q000737:chemistry*
D011135:Polysaccharides, Bacterial; D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose; C002563:xanthan gum
Granulation kinetics; Planetary mixer; Texture analysis; Wet granulation