Impaired increase of plasma abscisic Acid in response to oral glucose load in type 2 diabetes and in gestational diabetes.
The plant hormone abscisic acid (ABA) is present and active in humans, regulating glucose homeostasis. In normal glucose tolerant (NGT) human subjects, plasma ABA (ABAp) increases 5-fold after an oral glucose load. The aim of this study was to assess the effect of an oral glucose load on ABAp in type 2 diabetes (T2D) subjects. We chose two sub-groups of patients who underwent an oral glucose load for diagnostic purposes: i) 9 treatment-naive T2D subjects, and ii) 9 pregnant women with gestational diabetes (GDM), who underwent the glucose load before and 8-12 weeks after childbirth. Each group was compared with matched NGT controls. The increase of ABAp in response to glucose was found to be abrogated in T2D patients compared to NGT controls. A similar result was observed in the women with GDM compared to pregnant NGT controls; 8-12 weeks after childbirth, however, fasting ABAp and ABAp response to glucose were restored to normal in the GDM subjects, along with glucose tolerance. We also retrospectively compared fasting ABAp before and after bilio-pancreatic diversion (BPD) in obese, but not diabetic subjects, and in obese T2D patients, in which BPD resulted in the resolution of diabetes. Compared to pre-BPD values, basal ABAp significantly increased 1 month after BPD in T2D as well as in NGT subjects, in parallel with a reduction of fasting plasma glucose. These results indicate an impaired hyperglycemia-induced ABAp increase in T2D and in GDM and suggest a beneficial effect of elevated ABAp on glycemic control.
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Pietro
P
Ameri
Department of Experimental Medicine, Section of Biochemistry and CEBR, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.
Santina
S
Bruzzone
Department of Experimental Medicine, Section of Biochemistry and CEBR, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.
Elena
E
Mannino
Department of Experimental Medicine, Section of Biochemistry and CEBR, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.
Giovanna
G
Sociali
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Gabriella
G
Andraghetti
Department of Experimental Medicine, Section of Biochemistry and CEBR, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.
Annalisa
A
Salis
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Monica Laura
ML
Ponta
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Lucia
L
Briatore
Department of surgical sciences and integrated diagnostic, University of Genova, Largo R. Benzi 8, 16132 Genova, Italy.
Giovanni F
GF
Adami
IRCSS San Martino IST, Largo R. Benzi 10, 16132 Genova, Italy.
Antonella
A
Ferraiolo
IRCSS San Martino IST, Largo R. Benzi 10, 16132 Genova, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Mother and Child Sciences, University of Genova, Largo P. Daneo, 3, 16132 Genova, Italy.
Pier Luigi
PL
Venturini
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Davide
D
Maggi
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Renzo
R
Cordera
Department of Internal Medicine, University of Genova, Viale Benedetto XV/6, 16132 Genova, Italy.
Giovanni
G
Murialdo
Department of Experimental Medicine, Section of Biochemistry and CEBR, University of Genova, Viale Benedetto XV/1, 16132 Genova, Italy.
Elena
E
Zocchi
D000040:Abscisic Acid / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D008875:Middle Aged; D011247:Pregnancy; D055815:Young Adult
D001786:Blood Glucose; D000040:Abscisic Acid