Late hepatic metastasis from a duodenal gastrointestinal stromal tumor (29 years after surgery): report of a case and review of the literature.
Gastrointestinal stromal tumor (GIST) metastases are found most commonly in the liver, on average 16 to 38 months after resection of the primary tumor, even if some delayed hepatic metastases from GISTs have been described. We report a case of a man with a giant liver mass at computed tomography scan. In September 1984, the patient had undergone resection of a duodenal tumor, diagnosed as schwannoma. A liver biopsy revealed a neoplasm composed of epithelioid and spindled cells, immunohistochemically positive to c-kit and Dog-1. Reexamining the duodenal tumor resected in 1984, it was reclassified as GIST. Sequencing revealed the same mutation of the c-kit gene in both duodenal and hepatic lesions. To the best of our knowledge, this case represents the longest disease-free interval between a primary GIST and its metastasis. A brief review of the literature and an analysis of the potential prognostic role of particular c-kit mutations are also provided.
University of Siena, Siena, Italy ginori@student.unisi.it.
Alessandro
A
Ginori
University of Siena, Siena, Italy.
Francesco
F
Scaramuzzino
Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Stefania
S
Marsili
Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Sergio
S
Tripodi
D000328:Adult; D017668:Age of Onset; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D004252:DNA Mutational Analysis; D004379:Duodenal Neoplasms / Q000235:genetics / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000235:genetics / Q000556:secondary*; D008297:Male; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit
c-kit gene; gastrointestinal stromal tumors; imatinib; late hepatic metastasis; risk assessment