Interrupting synoviolin play at the ER: a plausible action to elevate mitochondrial energetics and silence obesity.
Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis,non-alcoholic fatty liver, and cancer. In this issue of The EMBO Journal,Fujita et al (2015) describe the role of an endoplasmic reticulum (ER)-resident E3ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC-1b, a transcriptional modulator of mitochondrial oxidative metabolism.
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Meghan S
MS
Soustek
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Pere
P
Puigserver
D000818:Animals; D001835:Body Weight / Q000235:genetics*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*
D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases