Oxcarbazepine induced maculopapular rash - a case report.
Unlike carbamazepine, newer anti epileptic drug like oxcarbazepine, reports fewer side effects. In this report we describe a case of oxcarbazepine induced maculopapular rash probably happened because of a drug interaction with isoniazid, and a brief review of the existing literature is presented herewith. A 40-year-old male patient received oxcarbazepine 300mg twice daily along with other anti-tubercular drugs including isoniazid (300mg) once daily since two days. Extensive cutaneous rash with intense itching developed which subsided on discontinuation of oxcarbazepine. This case highlights the fact that there is a potential possibility of drug-drug interaction between oxcarbazepine and isoniazid and concomitant use of these two drugs should better be avoided during clinical practice.
Post Doctoral Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine , 108, C.R. Avenue, Kolkata, India .
Arunava
A
Biswas
Assistant Professor, Department of Pulmonary Medicine, Institute of Post Graduate Medical Education & Research , Circus Ave, Bhawanipur, Kolkata, India .
Ritabrata
R
Mitra
Post Doctoral Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine , 108, C.R. Avenue, Kolkata, India .
Sukanta
S
Sen
Post Graduate Trainee, Department of Clinical & Experimental Pharmacology, Calcutta School of Tropical Medicine , 108, C.R. Avenue, Kolkata, India .
Agnik
A
Pal
Professor and HOD, Department of Clinical & Experimental, Pharmacology, Calcutta School of Tropical Medicine , 108, C.R. Avenue, Kolkata, India .
Santanu Kumar
SK
Tripathi
Isoniazid; Maculopapular rash; Oxcarbazepine