Alterations in cognitive flexibility in a rat model of post-traumatic stress disorder.
Exposure to stressful or traumatic events is associated with increased vulnerability to post-traumatic stress disorder (PTSD). This vulnerability may be partly mediated by effects of stress on the prefrontal cortex (PFC) and associated circuitry. The PFC mediates critical cognitive functions, including cognitive flexibility, which reflects an organism's ability to adaptively alter behavior in light of changing contingencies. Prior work suggests that chronic or acute stress exerts complex effects on different forms of cognitive flexibility, via actions on the PFC. Similarly, PFC dysfunction is reported in PTSD, as are executive function deficits. Animal models that permit study of the effects of stress/trauma on cognitive flexibility may be useful in illuminating ways in which stress-linked cognitive changes contribute to PTSD. Here, we examined the behavioral effects of a rodent model of PTSD - single prolonged stress (SPS) - on performance of two forms of cognitive flexibility: reversal learning and strategy set-shifting. SPS did not impair acquisition of either a response or visual-cue discrimination but did cause slight impairments in the retrieval of the visual-cue rule. During response discrimination reversal, SPS rats made more perseverative errors. In comparison, during set-shifting from the visual-cue to response discrimination, SPS rats did not show enhanced perseveration, but did display increased never-reinforced errors, indicative of impairment in selecting a novel strategy. These data demonstrate that SPS leads to a complex and intriguing pattern of deficits in flexible responding and suggest that impairments in executive functioning associated with PTSD could, in part, be a neuro-cognitive consequence of trauma exposure.
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA; Ann Arbor Veterans Affairs Hospital, 2215 Fuller Road, Ann Arbor, MI, 49105, USA. Electronic address: alicegeo@med.umich.edu.
Sophie A
SA
George
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA. Electronic address: mari.rodriguez221@gmail.com.
Mariana
M
Rodriguez-Santiago
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA. Electronic address: jpriley@umich.edu.
John
J
Riley
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA. Electronic address: jabelson@med.umich.edu.
James L
JL
Abelson
Department of Psychology, University of British Columbia, Vancouver, BC, Canada. Electronic address: floresco@psych.ubc.ca.
Stan B
SB
Floresco
Department of Psychiatry, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI, 48109, USA; Ann Arbor Veterans Affairs Hospital, 2215 Fuller Road, Ann Arbor, MI, 49105, USA. Electronic address: liberzon@med.umich.edu.
Israel
I
Liberzon
D000818:Animals; D003216:Conditioning, Operant; D003463:Cues; D004192:Discrimination, Psychological; D004195:Disease Models, Animal; D056344:Executive Function; D008297:Male; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D017207:Rats, Sprague-Dawley; D012193:Reversal Learning; D013313:Stress Disorders, Post-Traumatic / Q000523:psychology*; D014796:Visual Perception
Animal model; Executive function; PTSD; Reversal; Set-shifting; Single prolonged stress