Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.
Laboratory of Experimental Pulmonology and Inflammation Research, Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, University Hospital Southampton, Southampton, UK GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands m.de.vries04@umcg.nl.
Maaike
M
de Vries
Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
Natalie P
NP
Smithers
National Institute for Health Research Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK.
Peter H
PH
Howarth
Laboratory of Experimental Pulmonology and Inflammation Research, Dept of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Martijn C
MC
Nawijn
Brooke Laboratory, Academic Unit of Clinical and Experimental Sciences, University of Southampton, Faculty of Medicine, University Hospital Southampton, Southampton, UK National Institute for Health Research Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, UK.
Donna E
DE
Davies
D017209:Apoptosis / Q000187:drug effects*; D001980:Bronchi / Q000166:cytology; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000187:drug effects / Q000235:genetics; D054357:Chemokine CXCL10 / Q000187:drug effects / Q000235:genetics; D004847:Epithelial Cells / Q000187:drug effects* / Q000821:virology; D006801:Humans; D066298:In Vitro Techniques; D016899:Interferon-beta / Q000187:drug effects / Q000235:genetics; D007372:Interferons; D007378:Interleukins / Q000235:genetics; D051573:Proto-Oncogene Proteins c-pim-1 / Q000037:antagonists & inhibitors*; D012333:RNA, Messenger / Q000187:drug effects* / Q000378:metabolism; D012367:RNA, Viral / Q000032:analysis*; D012229:Rhinovirus / Q000187:drug effects*; D019562:Viral Load / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects*; D000095022:Interferon Lambda
D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D016899:Interferon-beta; D007372:Interferons; D007378:Interleukins; D051573:Proto-Oncogene Proteins c-pim-1; D012333:RNA, Messenger; D012367:RNA, Viral; C483024:CCL5 protein, human; C114753:CXCL10 protein, human; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C496634:PIM1 protein, human