Myeloperoxidase is associated with insulin resistance and inflammation in overweight subjects with first-degree relatives with type 2 diabetes mellitus.
BACKGROUND
Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM.


METHODS
Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase.


RESULTS
MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879).


CONCLUSIONS
MPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.
Biomedical Research Center of Michoacán, Mexican Institute of Social Security, Morelia, Mexico.
Anel
A
Gómez García
Family Medicine Unit N° 80, Mexican Institute of Social Security, Morelia, Mexico.
Mireya
M
Rivera Rodríguez
Biomedical Research Center of Michoacán, Mexican Institute of Social Security, Morelia, Mexico.
Carlos
C
Gómez Alonso
School of Chemical Pharmacobiology, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico.
Daysi Yazmin
DY
Rodríguez Ochoa
Biomedical Research Center of Michoacán, Mexican Institute of Social Security, Morelia, Mexico.
Cleto
C
Alvarez Aguilar
First-degree relatives of type 2 diabetes mellitus; Insulin resistance; Myeloperoxidase