Early surgical intervention and optimal medical treatment for Candida parapsilosis endocarditis.
We herein report the case of a 72-year-old man with endocarditis of the aortic valve who underwent urgent aortic valve replacement 36 hours after admission due to an aggravation of aortic valve regurgitation. Postoperative cultures of the blood and site of valve vegetation identified Candida parapsilosis as a pathogen. Antifungal therapy with amphotericin B and fluconazole was initiated after surgical treatment. Thereafter, the patient displayed a favorable clinical course. Candida parapsilosis endocarditis involving the native valves is extremely rare and associated with a very high mortality rate. Prompt surgical treatment and the aggressive use of antifungal agents are required to save the patient's life.
Department of Cardiovascular Medicine, Dokkyo Medical University, Japan.
Shigeru
S
Toyoda
Emi
E
Tajima
Reiko
R
Fukuda
Taito
T
Masawa
Shu
S
Inami
Hirohisa
H
Amano
Takuo
T
Arikawa
Atsushi
A
Yoshida
Akira
A
Hishinuma
Teruo
T
Inoue
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001021:Aortic Valve / Q000382:microbiology / Q000601:surgery; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000382:microbiology / Q000628:therapy*; D004696:Endocarditis / Q000382:microbiology* / Q000628:therapy*; D015725:Fluconazole / Q000627:therapeutic use; D006349:Heart Valve Diseases / Q000382:microbiology* / Q000628:therapy*; D006350:Heart Valve Prosthesis / Q000382:microbiology; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole