Connectivity and functional profiling of abnormal brain structures in pedophilia.
Despite its 0.5-1% lifetime prevalence in men and its general societal relevance, neuroimaging investigations in pedophilia are scarce. Preliminary findings indicate abnormal brain structure and function. However, no study has yet linked structural alterations in pedophiles to both connectional and functional properties of the aberrant hotspots. The relationship between morphological alterations and brain function in pedophilia as well as their contribution to its psychopathology thus remain unclear. First, we assessed bimodal connectivity of structurally altered candidate regions using meta-analytic connectivity modeling (MACM) and resting-state correlations employing openly accessible data. We compared the ensuing connectivity maps to the activation likelihood estimation (ALE) maps of a recent quantitative meta-analysis of brain activity during processing of sexual stimuli. Second, we functionally characterized the structurally altered regions employing meta-data of a large-scale neuroimaging database. Candidate regions were functionally connected to key areas for processing of sexual stimuli. Moreover, we found that the functional role of structurally altered brain regions in pedophilia relates to nonsexual emotional as well as neurocognitive and executive functions, previously reported to be impaired in pedophiles. Our results suggest that structural brain alterations affect neural networks for sexual processing by way of disrupted functional connectivity, which may entail abnormal sexual arousal patterns. The findings moreover indicate that structural alterations account for common affective and neurocognitive impairments in pedophilia. The present multimodal integration of brain structure and function analyses links sexual and nonsexual psychopathology in pedophilia.
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Timm B
TB
Poeppl
Simon B
SB
Eickhoff
Peter T
PT
Fox
Angela R
AR
Laird
Rainer
R
Rupprecht
Berthold
B
Langguth
Danilo
D
Bzdok
D000328:Adult; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D016208:Databases, Factual; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging; D008297:Male; D015201:Meta-Analysis as Topic; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D010378:Pedophilia / Q000473:pathology* / Q000503:physiopathology*; D012146:Rest; D012725:Sexual Behavior / Q000502:physiology
functional connectivity; functional magnetic resonance imaging (fMRI); meta-analytic connectivity modeling (MACM); neuroimaging; pedophilia; resting state