Hypertension in patients with cancer.
There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality.
Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Vinicius Barbosa de
VB
Souza
Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Eduardo Nani
EN
Silva
Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Mario Luiz
ML
Ribeiro
Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Wolney de Andrade
Wde A
Martins
D000959:Antihypertensive Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors
D000959:Antihypertensive Agents; D000970:Antineoplastic Agents