What Can Proteomics Tell Us about Tuberculosis?
Tuberculosis (TB) is an infectious disease transmitted by aerosol droplets and characterized by forming granulomatous lesions. Although the number of people infected in the population is high, the vast majority does not exhibit symptoms of active disease and only 5-10% develop the disease after a latent period that can vary from weeks to years. The bases of the immune response for this resistance are unknown, but it depends on a complex interaction between the environment, the agent, and the host. The analysis of cellular components of M. tuberculosis shows important host-pathogen interactions, metabolic pathways, virulence mechanisms, and mechanisms of adaptation to the environment. However, the M. tuberculosis proteome still remains largely uncharacterized in terms of virulence and pathogenesis. Here, we summarize some of the major proteomic studies performed to scrutinize all the mycobacterial components.
INIFAP, Centro Nacional de Investigación Disciplinaria en Fisiología y Mejoramiento Animal, Colón, Qro, México.
Susana
S
Flores-Villalva
INIFAP, Centro Nacional de Investigación Disciplinaria en Fisiología y Mejoramiento Animal, Colón, Qro, México.
Elba
E
Rogríguez-Hernández
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Qro, México.
Yesenia
Y
Rubio-Venegas
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Qro, México.
Jorge Germinal
JG
Cantó-Alarcón
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Querétaro, Qro, México.
Feliciano
F
Milián-Suazo
D001426:Bacterial Proteins / Q000032:analysis*; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000502:physiology*; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*; D014376:Tuberculosis / Q000382:microbiology*
D001426:Bacterial Proteins; D020543:Proteome
M. bovis; M. tuberculosis; cellular components; culture filtrate; proteome