Broad spectrum anti-microbial compounds producing bacteria from coast of Qingdao bays.
Anti-microbial resistance burden and hazard associated with chemical treatment of infections demanded for new anti-microbial natural products. Marine associated microorganisms are the enormous source of bioactive compounds. In this study we have isolated 272 marine bacteria among them 136 (50%) were antagonistic to at least one of the four pathogenic strains Listeria monocytogenes, Vibrio cholerae, E. coli and S. aureus. Only two strains exhibited antibacterial activity against all four test strains, which were identified by 16S rDNA sequencing as Bacillus sp. DK1-SA11 and Vibrio sp. DK6-SH8. Marine isolate DK1-SA11 has potential to resist boiling temperature and pH 2-12. Furthermore cell free extract (CFE) inhibited all test organisms including superbug MRSA and pathogenic yeast Candida albicans. Marine isolate Bacillus sp. DK1-SA11 could be a potential combatant for the battle of drugs and bugs.
Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, PR China / Microbiological Analytical Centre, FMRRC, PCSIR Labs. Complex Karachi, Pakistan.
Muhammad Naseem
MN
Khan
Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, PR China.
Meng
M
Li
Microbiological Analytical Centre, FMRRC, PCSIR Labs. Complex Karachi, Pakistan.
Zulfiqar Ali
ZA
Mirani
Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, PR China.
Jingxue
J
Wang
Food Safety Laboratory, College of Food Science and Engineering, Ocean University of China, Qingdao, PR China.
Hong
H
Lin
Faculty of Marine Sciences, Lasbela University of Agriculture, Water and Marine Sciences, Uthal, Pakistan.
Muhammad Aslam
MA
Buzdar
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000302:isolation & purification* / Q000378:metabolism; D014871:Water Microbiology
D000900:Anti-Bacterial Agents