Influence of interleukin-1β and interleukin-6 gene polymorphisms on the development of acute pancreatitis.
We investigated the association between 3 main proinflammatory cytokines [interleukin (IL)-1β and IL-6] and the risk of acute pancreatitis. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796). The genotype distributions of IL-1β+3954 C/T (rs1143634) and IL-1β-511 C/T (rs16944) and IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796) were in Hardy-Weinberg equilibrium for the control group. Multivariate regression analyses showed that subjects carrying the rs1143634 TT genotype had a significantly increased risk of acute pancreatitis, with an adjusted odds ratio (95% confidence interval) of 2.11 (1.03-4.51). Subjects carrying the IL-1β rs1143634 TT genotype had a significantly increased risk of acute pancreatitis in our Chinese population.
Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
D Z
DZ
Chi
Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
J
J
Chen
Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China chidazhi282@163.com.
D P
DP
Huang
D000483:Alleles; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D053583:Interleukin-1beta; D015850:Interleukin-6