Adiponectin may mediate the association between omentin, circulating lipids and insulin sensitivity: results from the KORA F4 study.
OBJECTIVE
Reduced circulating omentin levels have been reported in obesity and type 2 diabetes, but data were mostly derived from univariate analyses in small study samples. This study aimed to investigate the relationship between omentin, abnormal glucose tolerance and related metabolic factors in a large population-based cross-sectional study.


METHODS
Serum omentin was measured by ELISA in 1092 participants of the German KORA F4 survey (2006-2008). Associations between omentin serum levels, glucose tolerance (assessed with an oral glucose tolerance test) and diabetes-related factors were estimated using logistic and linear regression models respectively.


RESULTS
Serum levels of omentin were not related to categories of glucose tolerance. However, serum omentin was positively associated with whole-body insulin sensitivity index (ISI (composite)) and HDL cholesterol and showed inverse associations with 2-h post-load glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance, BMI and triglycerides (all P≤0.03 after adjustment for age, sex and lifestyle factors). Further adjustment for BMI and/or serum lipids attenuated the associations with parameters of glucose metabolism, whereas adjustment for serum adiponectin virtually abolished all aforementioned associations. In contrast, adjustment for omentin had no effect on the positive association between adiponectin levels and ISI (composite).


CONCLUSIONS
The data from this large population-based cohort show that circulating omentin levels are associated with insulin sensitivity. Our observations further suggest that omentin acts via upregulation of adiponectin, which in turn affects lipid metabolism and thereby also indirectly enhances insulin sensitivity, but mechanistic studies are required to corroborate this hypothesis.
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Christian
C
Herder
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
D Margriet
DM
Ouwens
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Maren
M
Carstensen
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Bernd
B
Kowall
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Cornelia
C
Huth
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Christa
C
Meisinger
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Wolfgang
W
Rathmann
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Michael
M
Roden
Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Neuherberg, Ingolstädter Landstraße 1, 85764 Neuherberg, GermanyDepartment of Endocrinology and DiabetologyUniversity Hospital Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany Institute for Clinical DiabetologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyGerman Center for Diabetes Research (DZD e.V.)Partner Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Clinical Biochemistry and PathobiochemistryGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyDepartment of EndocrinologyGhent University Hospital, De Pintelaan 185, 9000 Ghent, BelgiumInstitute of Biometrics and EpidemiologyGerman Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, GermanyInstitute of Epidemiology IIHelmholtz Z
Barbara
B
Thorand
D052242:Adiponectin / Q000097:blood / Q000502:physiology*; D000368:Aged; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D005858:Germany / Q000453:epidemiology; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology; D006801:Humans; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors
C499918:ADIPOQ protein, human; D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D008055:Lipids