False-Positive PET/CT After Cyanoacrylate Sealing of a Pancreaticojejunostomy.
In 2013, a 68-year-old male had a pancreaticoduodenectomy for pancreatic cancer. The pancreaticojejunostomy was sealed with cyanoacrylate (Dermabond) to prevent postoperative pancreatic fistula. Local recurrence of malignancy at the anastomosis was suspected 18 months later in PET/CT. Surgical revision was performed and anastomosis resected. However, histology showed no tumor recurrence, but strong inflammation and foreign-body reaction towards Dermabond. The sealant caused false-positive PET/CT findings, so its use in oncologic surgery should be abandoned.
Department of Surgery, St. Josef Hospital, Ruhr University of Bochum, Gudrunstr. 56, 44791, Bochum, Germany, o.belyaev@klinikum-bochum.de.
Orlin
O
Belyaev
Johanna
J
Munding
Andrea
A
Tannapfel
Waldemar
W
Uhl
D000368:Aged; D003487:Cyanoacrylates / Q000008:administration & dosage*; D003951:Diagnostic Errors; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010185:Pancreatic Fistula / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects; D010193:Pancreaticojejunostomy / Q000379:methods*; D049268:Positron-Emission Tomography; D012086:Reoperation; D014014:Tissue Adhesives / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed
D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate