The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications.
Pinocembrin is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown anti-inflammatory and neuroprotective effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitochondrial function, and regulate apoptosis. Considering these pharmaceutical characteristics, pinocembrin has potential as a drug to treat ischemic stroke and other clinical conditions. In this review, we summarize its pharmacologic characteristics and discuss its mechanisms of action and potential therapeutic applications.
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370B, Baltimore, MD, 21205, USA.
Xi
X
Lan
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370B, Baltimore, MD, 21205, USA.
Wenzhu
W
Wang
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370B, Baltimore, MD, 21205, USA.
Qiang
Q
Li
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Bldg 370B, Baltimore, MD, 21205, USA. jwang79@jhmi.edu.
Jian
J
Wang
D000818:Animals; D044950:Flavanones / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005419:Flavonoids / Q000096:biosynthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008954:Models, Biological; D018696:Neuroprotective Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*
D044950:Flavanones; D005419:Flavonoids; D018696:Neuroprotective Agents; C016063:pinocembrin
Neuroinflammation; Neuroprotection; Pinocembrin; Stroke