Regulation of cell adhesion and cell sorting at embryonic boundaries.
Embryonic boundaries are sharp delimitations that prevent intermingling between different cell populations. They are essential for the development of well-organized structures and ultimately a functional organism. It has been long believed that this process was driven by global differences in cell adhesion strength, or expression of different types of adhesion molecules. The actual picture turns out to be quite different: Boundaries should be viewed as abrupt discontinuities, where cortical contractility is acutely upregulated in response to specific cell surface contact receptors which act as repulsive cues. Cell adhesion is also modulated along the interface, in different ways depending on the type of boundary, but in all cases the process is subordinated to the function of the cortical actomyosin cytoskeleton.
Department of Biology, McGill University, Montréal, Québec, Canada. Electronic address: francois.fagotto@mcgill.ca.
François
F
Fagotto
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002454:Cell Differentiation; D004622:Embryo, Mammalian / Q000166:cytology* / Q000378:metabolism; D047108:Embryonic Development; D006801:Humans; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*
D015815:Cell Adhesion Molecules
CAMs; Cadherins; Contact inhibition; Differential adhesion; Eph receptors; Ephrins; Gastrulation; Morphogenesis; Protocadherins