Somatostatin cells regulate sensory response fidelity via subtractive inhibition in olfactory cortex.
Diverse types of local GABAergic interneurons shape the cortical representation of sensory information. Here we show how somatostatin-expressing interneurons (SOM cells) contribute to odor coding in mouse olfactory cortex. We find that odor-tuned SOM cells regulate principal cells through a purely subtractive operation that is independent of odor identity or intensity. This operation enhances the salience of odor-evoked activity without changing cortical odor tuning. SOM cells inhibit both principal cells and fast-spiking interneurons, indicating that subtractive inhibition reflects the interplay of multiple classes of interneurons.
Center for Neural Circuits and Behavior, Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, California, USA.
James F
JF
Sturgill
Center for Neural Circuits and Behavior, Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, California, USA.
Jeffry S
JS
Isaacson
D000818:Animals; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D009433:Neural Inhibition / Q000502:physiology*; D009812:Odorants; D055696:Olfactory Perception / Q000502:physiology*; D062308:Optogenetics; D018408:Patch-Clamp Techniques; D066195:Piriform Cortex / Q000502:physiology*; D019864:Somatostatin-Secreting Cells / Q000502:physiology*