Meta-Analysis of Association Between Interleukin-1β C-511T Polymorphism and Chronic Periodontitis Susceptibility.
BACKGROUND
Many studies have been conducted to explore the association between interleukin (IL)-1β C-511T polymorphism and risk of chronic periodontitis (CP) but with different or even contradictory results. A meta-analysis was performed to further explore their association.


METHODS
PubMed, Chinese National Knowledge Infrastructure, and EMBASE were searched up to September 30, 2014 for relevant case-control studies. Two authors (D-YL and L-YX) independently selected studies and extracted data from included studies. The meta-analysis was performed using comprehensive meta-analysis software.


RESULTS
Nineteen case-control studies involving 2,173 patients with CP and 3,900 healthy controls were included. Using a random-effects meta-analysis model, a non-significant association between IL-1β C-511T polymorphism and CP was identified (T versus C: odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.85 to 1.25; TT versus CC: OR = 1.03, 95% CI = 0.72 to 1.46; CT versus CC: OR = 0.96, 95% CI = 0.71 to 1.30; CT + TT versus CC: OR = 1.00, 95% CI = 0.74 to 1.34; TT versus CT + CC: OR = 1.05, 95% CI = 0.81 to 1.38), and sensitivity analysis indicated that the results were robust. Subgroup analyses also revealed a non-significant association. No publication bias was detected.


CONCLUSIONS
Based on currently available evidence, IL-1β C-511T polymorphism is not associated with the risk of developing CP. Additional research is warranted to further explore and confirm the association of genetic polymorphism and CP.
*Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University, Wuhan, China.
Xian-Tao
XT
Zeng
†Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Dong-Yan
DY
Liu
‡Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Joey S W
JS
Kwong
†Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Wei-Dong
WD
Leng
†Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Ling-Yun
LY
Xia
†Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Min
M
Mao
D000483:Alleles; D055113:Chronic Periodontitis / Q000235:genetics*; D003596:Cytosine; D005787:Gene Frequency / Q000235:genetics; D005799:Genes, Dominant; D005808:Genes, Recessive; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D013941:Thymine
D053583:Interleukin-1beta; D003596:Cytosine; D013941:Thymine
Chronic periodontitis; interleukin-1; meta-analysis; periodontal diseases; periodontitis; polymorphism, genetic