A modified international prognostic index including pretreatment hemoglobin level for early stage extranodal natural killer/T cell lymphoma.
In this study, we investigated the prognostic role of pretreatment hemoglobin level in 321 patients with stage I/II extranodal natural killer (NK/T cell lymphoma (ENKTL). Patients with pretreatment hemoglobin level < 120 g/L had significantly inferior progression-free survival (PFS) and overall survival (OS) than those with hemoglobin level ≥ 120 g/L (p < 0.05). In a multivariate Cox regression model, age, Eastern Cooperative Oncology Group (performance status), lactate dehydrogenase level, Ann Arbor stage and pretreatment hemoglobin level were all independent prognostic factors for PFS and OS (p < 0.05). Using these five parameters, a modified international prognostic index (mIPI) model was constructed. This mIPI could categorize three groups with significantly different PFS and OS (both p < 0.0001) in both the training set and the validation set. In conclusion, this study confirmed the prognostic role of pretreatment hemoglobin level in ENKTL, and a newly modified IPI including pretreatment hemoglobin level could be used to further optimize treatments for patients with stage I/II ENKTL, especially in the era of asparaginase.
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|b Department of Hematologic Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Liang
L
Wang
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|b Department of Hematologic Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Zhong-jun
ZJ
Xia
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|b Department of Hematologic Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Yue
Y
Lu
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|c Department of Radiation Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Qiao-xuan
QX
Wang
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|d Department of Radiation Center , the first affiliated hospital of Sun Yat-sen University , Guangzhou , Guangdong , People's Republic of China.
Shao-qing
SQ
Niu
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|e Department of Medical Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Hui-qiang
HQ
Huang
a State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Guangzhou , Guangdong , People's Republic of China.|c Department of Radiation Oncology , Sun Yat-sen University Cancer Center , Guangzhou , Guangdong , People's Republic of China.
Yu-jing
YJ
Zhang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000209:etiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D002648:Child; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D006454:Hemoglobins
Anemia; extranodal NK/T cell lymphoma; hemoglobin; international prognostic index; prognosis