Role of dendritic cell subsets in immunity and their contribution to noninfectious uveitis.
Dendritic cells (DCs) are a heterogeneous population. Murine DCs consist of conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In humans, the analogous populations are myeloid DCs (mDCs) and pDCs. Though distinct in phenotypes and functions, studies have shown that these DC subsets may interact or "crosstalk" during immune responses. For example, cDCs may facilitate pDC maturation, and pDCs may enhance antigen presentation of cDCs in certain pathogenic conditions or even take on a cDC phenotype themselves. The role of DCs in noninfectious uveitis has been studied primarily in the experimental autoimmune uveitis mouse model and to a more limited extent in patients. Recent evidence shows that the number, phenotype, and function of DC subsets are altered in this disease. We provide an overview of selected recent developments of pDCs and cDCs/mDCs, with special attention to their interaction and the dual roles of DC subsets in noninfectious uveitis.
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ping
P
Chen
Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Alastair K
AK
Denniston
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sima
S
Hirani
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Susan
S
Hannes
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: nussenblattr@nei.nih.gov.
Robert B
RB
Nussenblatt
D000818:Animals; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014605:Uveitis / Q000276:immunology*
conventional dendritic cells; experimental autoimmune uveitis; myeloid dendritic cells; noninfectious uveitis; plasmacytoid dendritic cells