Association of PTPN22 gene polymorphism with type 1 diabetes mellitus in Chinese children and adolescents.
Previous studies have indicated that the protein tyrosine phosphatase nonreceptor type 22 gene (PTPN22) is associated with type 1 diabetes (T1DM) in the Caucasian population. In the present study, we investigated the relationship between PTPN22 genetic polymorphisms and T1DM in Chinese children. A total of 202 children and adolescents with T1DM and 240 healthy control subjects of Chinese Han origin were included in our analysis. Polymerase chain reaction-restriction fragment length polymorphism was used to determine the presence of the C1858T polymorphism in the PTPN22 gene. We found that the TT +TC genotype and the T allele of C1858T were more frequent in T1DM patients (19.40 and 10.0%, respectively) than in healthy subjects (7.51 and 4.0%, respectively), and the difference was significant (both P < 0.001). After adjusting for confounding variables such as gender, age, and family history of T1DM, the difference remained significant (P = 0.007, odds ratio = 2.88, 95% confidence interval 1.76-4.32). Our results indicate that genetic polymorphisms in the PTPN22 gene may increase the risk of T1DM in Chinese children and adolescents.
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China liuhuawei1900@yeah.net.
H W
HW
Liu
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
R Y
RY
Xu
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
R P
RP
Sun
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, China.
Q
Q
Wang
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
J L
JL
Liu
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
W
W
Ge
Department of Pediatrics, Qilu Hospital of Shandong University, Jinan, China.
Z
Z
Yu
D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*
C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22