[Two cases of neuroendocrine tumors of the pancreas with multiple liver metastases treated by use of degradable starch microspheres and octreotide].
The first case involved a 38-year-old man who received a pancreaticoduodenectomy and hepatectomy for a pancreatic neuroendocrine tumor (pNET) with multiple liver metastases. A recurrent tumor was detected in his liver 3 months after surgery. The second case involved a 61-year-old woman who received a distal pancreatectomy for a pNET. Multiple liver metastases were detected 29 months later. Both patients received a combined therapy consisting of trans-catheter arterial chemoembolization (TACE) with degradable starch microspheres (DSM) and octreotide. The combined therapy prolonged progression-free survival in both cases. Although only 2 cases were evaluated in this study, multimodal treatment consisting of TACE with DSM and octreotide effectively controlled liver metastasis of pNET in both cases.
Dept. of Hepato-Biliary-Pancreatic Surgery and Gastroenterological Surgery, Osaka City General Hospital.
Wataru
W
Goto
Sadatoshi
S
Shimizu
Masaya
M
Kotsuka
Masayuki
M
Sakae
Akishige
A
Kanazawa
Tadashi
T
Tsukamoto
Yoshito
Y
Yamashita
Yukio
Y
Nishiguchi
D000328:Adult; D016461:Chemoembolization, Therapeutic; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000556:secondary / Q000628:therapy*; D015282:Octreotide / Q000008:administration & dosage*; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D013213:Starch / Q000008:administration & dosage*
C083286:degradable starch microspheres; D013213:Starch; D015282:Octreotide