Site-specific chemical modification of peptide and protein by thiazolidinediones.
A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change.
Peng
P
Wang
Shumei
S
Zhang
Qiuyue
Q
Meng
Ying
Y
Liu
Luqing
L
Shang
Zheng
Z
Yin
D000447:Aldehydes / Q000737:chemistry; D000595:Amino Acid Sequence; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D045162:Thiazolidinediones / Q000737:chemistry*
D000447:Aldehydes; D010455:Peptides; D011506:Proteins; D045162:Thiazolidinediones; C116609:3-hydroxybutanal