EBV, HSV, CMV and HPV in laryngeal and oropharyngeal carcinoma in Polish patients.
The role of viruses in the etiology of oral cancer has been proposed in many studies. The aim of the present study was to analyze the prevalence of Epstein-Barr virus, Human Herpes virus type 1, Cytomegalovirus and Human Papilloma virus among patients with oral squamous cell carcinoma in a Polish population. We investigated fresh-frozen tumor tissue fragments obtained from 80 patients with OSCC using the polymerase chain reaction assay. HPV was detected in 32.5% (22.5% were HPV 16), more often in laryngeal (36%) than in oropharyngeal carcinoma (26.6%). EBV was identified in 57.5%, HHV-1 in 7.5%, and CMV in 10% of patients. Co-infection with one or more viruses was detected in 30% of cases and most frequently it was co-infection with EBV and HPV (15%). Further studies are necessary to determine the potential role of EBV and the possible importance of HHV-1 as an infection co-factor in oropharyngeal cancer.
Department of Virology, Medical University of Lublin, Lublin, Poland dorota.polz@umlub.pl.
Dorota
D
Polz-Gruszka
Department of Virology, Medical University of Lublin, Lublin, Poland.
Agnieszka
A
Stec
Department of Virology, Medical University of Lublin, Lublin, Poland.
Jakub
J
Dworzański
Department of Virology, Medical University of Lublin, Lublin, Poland.
Małgorzata
M
Polz-Dacewicz
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D003587:Cytomegalovirus / Q000302:isolation & purification*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000821:virology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D018139:Simplexvirus / Q000302:isolation & purification*
CMV; EBV; Epstein-Barr virus; HHV-1; HPV; OSCC; Oral squamous cell carcinoma; cytomegalovirus; human herpes virus-1; human papilloma virus; larynx; oropharynx