A twin study of the trough plasma steady-state concentration of metformin.
OBJECTIVE
The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs.


METHODS
We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose.


RESULTS
There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs.


CONCLUSIONS
The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.
aClinical Pharmacology, Department of Public Health, University of Southern Denmark bEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark cDepartment of Clinical Chemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Tore B
TB
Stage
Per
P
Damkier
Rasmus S
RS
Pedersen
Mette M H
MM
Christensen
Lene
L
Christiansen
Kaare
K
Christensen
Kim
K
Brosen
D000293:Adolescent; D000328:Adult; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008687:Metformin / Q000097:blood* / Q000493:pharmacokinetics; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D008687:Metformin