From respiratory sensitization to food allergy: Anaphylactic reaction after ingestion of mushrooms (Agaricus bisporus).
We report a case of a 38-year-old mold-allergic patient who developed episodes of generalized urticaria and systemic anaphylactic shock immediately after ingesting button mushrooms. A manganese-dependent superoxide dismutase (MnSOD) and a NADP-dependent mannitol dehydrogenase (MtDH) from Agaricus bisporus mushroom were identified as patient-specific IgE-binding proteins. Cross-reactivity between A. bisporus MnSOD and mold aeroallergens was confirmed. We conclude that prior sensitization to mold aeroallergens might explain severe food reactions to cross-reacting homologs mushroom proteins.
Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, Laboratory of Parasitology and Immunoallergy, Center for Research Laskaray, University of the Basque Country, Paseo Universidad, 6, 01006 Vitoria, Álava, Spain.
Marta F
MF
Gabriel
Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain.
Purificación
P
González-Delgado
Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, Laboratory of Parasitology and Immunoallergy, Center for Research Laskaray, University of the Basque Country, Paseo Universidad, 6, 01006 Vitoria, Álava, Spain.
Idoia
I
Postigo
Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain ; Department of Medicine, Faculty of Medicine, University Miguel Hernández, Alicante-Valencia Road, 03550 San Joan, Alicante, Spain.
Javier
J
Fernández
Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain.
Victor
V
Soriano
Allergy Section, University General Hospital of Alicante, Calle Pintor Baeza s/n, 03010 Alicante, Spain.
Begoña
B
Cueva
Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, Laboratory of Parasitology and Immunoallergy, Center for Research Laskaray, University of the Basque Country, Paseo Universidad, 6, 01006 Vitoria, Álava, Spain.
Jorge
J
Martínez
Agaricus bisporus; Anaphylaxis; Cross-reactivity; Food allergy; Mold allergy