The JAK-STAT signaling pathway is differentially activated in CALR-positive compared with JAK2V617F-positive ET patients.
Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Winnie W Y
http://orcid.org/0000-0003-1209-1854
WW
Lau
Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge United Kingdom.
Rebecca
R
Hannah
Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom Department of Haematology, Addenbrooke's Hospital, Cambridge, United Kingdom.
Anthony R
AR
Green
Cambridge Institute for Medical Research and Wellcome Trust/Medical Research Council, Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Bertie
http://orcid.org/0000-0001-6302-5705
B
Göttgens
D019943:Amino Acid Substitution; D037282:Calreticulin / Q000235:genetics*; D063990:Gene Ontology; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics* / Q000378:metabolism*; D008533:Megakaryocytes / Q000378:metabolism; D050505:Mutant Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D050791:STAT Transcription Factors / Q000378:metabolism*; D015398:Signal Transduction; D013920:Thrombocythemia, Essential / Q000235:genetics* / Q000378:metabolism*
C576483:CALR protein, human; D037282:Calreticulin; D050505:Mutant Proteins; D050791:STAT Transcription Factors; C507924:JAK2 protein, human; D053614:Janus Kinase 2