Influence of inflammation on voriconazole metabolism.
Voriconazole pharmacokinetics shows a large inter- and intrapatient variability. Inflammation is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the influence of inflammation, marked by C-reactive protein (CRP) levels in blood, on the metabolism of voriconazole. Observational data showed an association between CRP level and the ratio of voriconazole N-oxide to voriconazole.
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands University of Groningen, Department of Pharmacy, Division of Pharmacokinetics, Toxicology and Targeting, Groningen, the Netherlands.
M A
MA
Encalada Ventura
University of Groningen, University Medical Center Groningen, Department of Hematology, Groningen, the Netherlands.
L F R
LF
Span
Eindhoven University of Technology, Department of Mathematics and Computer Science, Eindhoven, the Netherlands.
E R
ER
van den Heuvel
University of Groningen, Department of Pharmacy, Division of Pharmacokinetics, Toxicology and Targeting, Groningen, the Netherlands.
G M M
GM
Groothuis
University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, the Netherlands j.w.c.alffenaar@umcg.nl.
J-W C
JW
Alffenaar
D002097:C-Reactive Protein / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D065819:Voriconazole / Q000378:metabolism* / Q000493:pharmacokinetics
D002097:C-Reactive Protein; D065819:Voriconazole