Ultrasonic delivery of silica-gold nanoshells for photothermolysis of sebaceous glands in humans: Nanotechnology from the bench to clinic.
Recent advances in nanotechnology have provided numerous opportunities to transform medical therapies for the treatment of diseases including cancer, atherosclerosis, and thrombosis. Here, we report, through in vitro studies and in vivo human pilot clinical studies, the use of inert, inorganic silica-gold nanoshells for the treatment of a widely prevalent and researched, yet poorly treated disease of acne. We use ~150nm silica-gold nanoshells, tuned to absorb near-IR light and near-IR laser irradiation to thermally disrupt overactive sebaceous glands in the skin which define the etiology of acne-related problems. Low-frequency ultrasound was used to facilitate deep glandular penetration of the nanoshells. Upon delivery of the nanoshells into the follicles and glands, followed by wiping of superficial nanoshells from skin surface and exposure of skin to near-infrared laser, nanoshells localized in the follicles absorb light, get heated, and induce focal thermolysis of sebaceous glands. Pilot human clinical studies confirmed the efficacy of ultrasonically-delivered silica-gold nanoshells in inducing photothermal disruption of sebaceous glands without damaging collateral skin.
Sebacia Inc., 2905 Premiere Parkway, Suite 150, Duluth, GA 30097, United States. Electronic address: dilip@sebacia.com.
Dilip
D
Paithankar
Department of Chemical Engineering, Center for Bionengineering, University of California, Santa Barbara, CA 93106, United States.
Byeong Hee
BH
Hwang
Dermatology, Laser, and Vein Specialists of the Carolinas, 1918 Randolph Rd, Ste 550, Charlotte, NC 28207, United States.
Girish
G
Munavalli
New York Laser & Skin Care, 1044 5th Avenue, New York, NY 10028, United States.
Arielle
A
Kauvar
Lloyd Dermatology & Laser Center, 8060 Market St, Youngstown, OH 44512, United States.
Jenifer
J
Lloyd
Sebacia Inc., 2905 Premiere Parkway, Suite 150, Duluth, GA 30097, United States.
Richard
R
Blomgren
Sebacia Inc., 2905 Premiere Parkway, Suite 150, Duluth, GA 30097, United States.
Linda
L
Faupel
Sebacia Inc., 2905 Premiere Parkway, Suite 150, Duluth, GA 30097, United States.
Todd
T
Meyer
Department of Chemical Engineering, Center for Bionengineering, University of California, Santa Barbara, CA 93106, United States. Electronic address: samir@engineering.ucsb.edu.
Samir
S
Mitragotri
D000152:Acne Vulgaris / Q000473:pathology / Q000628:therapy*; D000818:Animals; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D007259:Infrared Rays; D028022:Low-Level Light Therapy / Q000379:methods; D050997:Nanomedicine / Q000379:methods*; D057145:Nanoshells / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D036103:Nanotechnology / Q000379:methods; D012627:Sebaceous Glands / Q000473:pathology*; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D013552:Swine; D014465:Ultrasonics / Q000379:methods
D006046:Gold; D012822:Silicon Dioxide
Clinical; Follicle; Nanoparticle; Nanoshells; Photothermal; Translation