Methods for biomimetic remineralization of human dentine: a systematic review.
This study aimed to review the laboratory methods on biomimetic remineralization of demineralized human dentine. A systematic search of the publications in the PubMed, TRIP, and Web of Science databases was performed. Titles and abstracts of initially identified publications were screened. Clinical trials, reviews, non-English articles, resin-dentine interface studies, hybrid layer studies, hybrid scaffolds studies, and irrelevant studies were excluded. The remaining papers were retrieved with full texts. Manual screening was conducted on the bibliographies of remaining papers to identify relevant articles. A total of 716 studies were found, and 690 were excluded after initial screening. Two articles were identified from the bibliographies of the remaining papers. After retrieving the full text, 23 were included in this systematic review. Sixteen studies used analogues to mimic the functions of non-collagenous proteins in biomineralization of dentine, and four studies used bioactive materials to induce apatite formation on demineralized dentine surface. One study used zinc as a bioactive element, one study used polydopamine, and another study constructed an agarose hydrogel system for biomimetic mineralization of dentine. Many studies reported success in biomimetic mineralization of dentine, including the use of non-collagenous protein analogues, bioactive materials, or elements and agarose hydrogel system.
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. ql-li@126.com.|Key Laboratory of Oral Diseases Research of Anhui Province, Stomatological Hospital & College, Anhui Medical University, Hefei 230032, China. ql-li@126.com.
Chris Ying
CY
Cao
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. modelbaby1981@gmail.com.
May Lei
ML
Mei
Key Laboratory of Oral Diseases Research of Anhui Province, Stomatological Hospital & College, Anhui Medical University, Hefei 230032, China. ql-li@126.com.
Quan-Li
QL
Li
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. hrdplcm@hku.hk.
Edward Chin Man
EC
Lo
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China. chchu@hku.hk.
Chun Hung
CH
Chu
D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D032701:Biomimetics / Q000379:methods*; D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology; D003738:Dental Cements / Q000737:chemistry / Q000494:pharmacology; D003804:Dentin / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D014089:Tooth Remineralization / Q000379:methods*
D000180:Acrylic Resins; D001672:Biocompatible Materials; D002130:Calcium Phosphates; D003738:Dental Cements; C006903:carbopol 940; C020243:calcium phosphate