Evaluation of regional cerebral blood flow in patient with atypical senile dementia with asymmetrical calcification.
We report an 83-year-old woman with atypical senile dementia with Fahr-type calcification. Brain computed tomography demonstrated asymmetrical calcification predominant in the basal ganglia on the right side and pronounced diffuse cortical atrophy in the frontotemporal areas. The patient was clinically diagnosed with diffuse neurofibrillary tangles with calcification. Brain single photon emission computed tomography findings revealed that cerebral blood flow was reduced on the right side, as compared with the left side, in widespread areas. Hemispheric asymmetry in both calcification and cerebral blood flow suggests a relationship between calcification and vascular changes.
Mihara Hospital, Sakai, Japan.|Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
Masaru
M
Shoyama
Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
Satoshi
S
Ukai
Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan.
Kazuhiro
K
Shinosaki
D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000175:diagnosis*; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology*; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D016874:Neurofibrillary Tangles / Q000000981:diagnostic imaging / Q000473:pathology*; D015898:Tomography Scanners, X-Ray Computed; D015899:Tomography, Emission-Computed, Single-Photon
asymmetrical calcification; cerebral blood flow; diffuse neurofibrillary tangles with calcification