For longevity, perception is everything.
Aging is a risk factor for chronic diseases, and identifying targets for intervention is a goal of the aging field. Burkewitz et al. now describe a mechanism that mediates the specific role for AMPK in longevity, whereby its activity in neurons modulates metabolism and mitochondrial integrity in peripheral tissues.
Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA.
Vanisha
V
Lakhina
Department of Molecular Biology and LSI Genomics, Princeton University, Princeton NJ 08544, USA. Electronic address: ctmurphy@princeton.edu.
Coleen T
CT
Murphy
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism*
C556192:CRTC-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D002395:Catecholamines; D015534:Trans-Activators