Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia.
BACKGROUND
Higher 1st trimester maternal serum levels of interferon-induced protein 10 (IP-10) and interferon inducible T-cell alpha chemoattractant (ITAC) are reported in gestations complicated with preeclampsia. However, parallel results in the fetal circulation are lacking.


OBJECTIVE
To compare IP-10 and ITAC levels in neonatal cord blood from gestations complicated by severe preeclampsia vs. gestational age-matched controls.


METHODS
Umbilical cord vessels were sampled following delivery of women with severe preeclampsia (n=30) ≥36 weeks to measure plasma IP-10 and ITAC levels and compared to corresponding controls matched for parity as well as maternal and gestational age. Chemokines were measured by specific ELISAs and expressed as pg/mL. Rho Spearman's coefficients were calculated to establish correlations between chemokine values and various numeric variables.


RESULTS
Preeclamptic cases displayed significantly lower median plasma umbilical artery and vein levels of both chemokines when compared to controls (IP-10: 23.4 vs. 31.4 and 2.0 vs. 24.6 pg/mL, P<0.05; and ITAC: 2.0 vs. 13.9 and 11.9 vs. 31.6 pg/mL, P<0.05, in artery and vein, respectively). There was a significant correlation between levels of both chemokines (r2=0.616, P=0.0001), but not with other variables.


CONCLUSIONS
In contrast to elevated 1st trimester levels of IP-10 previously found in the maternal serum of women who later developed preeclampsia, this study found lower umbilical cord IP-10 and ITAC plasma levels in near-term gestations with established severe preeclampsia.
Peter
P
Chedraui
Emilio J
EJ
Solís
Faustino R
FR
Pérez-López
Fred
F
Schatz
Umit
U
Kayisli
Gustavo S
GS
Escobar
Rita
R
Loja-Chango
Luis
L
Hidalgo
Charles J
CJ
Lockwood
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D054357:Chemokine CXCL10 / Q000097:blood*; D054371:Chemokine CXCL11 / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology*; D011247:Pregnancy; D055815:Young Adult
D015415:Biomarkers; C114753:CXCL10 protein, human; C515202:CXCL11 protein, human; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11