Neurofilament proteins in axonal regeneration and neurodegenerative diseases.
Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is mediated by neurofilament-related proteins. Neurofilament protein regulates enzyme function and the structure of linker proteins. In addition, neurofilament gene expression plays an important role in nervous system development. Previous studies have shown that neurofilament gene transcriptional regulation is crucial for neurofilament protein expression, especially in axonal regeneration and degenerative diseases. Post-transcriptional regulation increased neurofilament protein gene transcription during axonal regeneration, ultimately resulting in a pattern of neurofilament protein expression. An expression imbalance of post-transcriptional regulatory proteins and other disorders could lead to amyotrophic lateral sclerosis or other neurodegenerative diseases. These findings indicated that after transcription, neurofilament protein regulated expression of related proteins and promoted regeneration of damaged axons, suggesting that regulation disorders could lead to neurodegenerative diseases.
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Haitao
H
Wang
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Minfei
M
Wu
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Chuanjun
C
Zhan
Department of Orthopedic Surgery, Beihua University Affiliated Hospital, Jilin 132000, Jilin Province, China.
Enyuan
E
Ma
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Maoguang
M
Yang
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Xiaoyu
X
Yang
Department of Spine Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Yingpu
Y
Li
axonal regeneration; nerve injury; neurodegenerative diseases; neurofilament protein; post-transcriptional regulation; reviews