A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer.
OBJECTIVE
A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) was recently described to promote the invasion-metastasis cascade in hepatocellular carcinoma. The aim of the present study was to clarify the clinicopathological role and prognostic relevance of lncRNA-ATB in colorectal cancer (CRC).


METHODS
lncRNA-ATB expression was evaluated by real-time reverse transcription polymerase chain reaction in 124 patients with CRC. Patients were divided into two groups based on the median lncRNA-ATB expression.


RESULTS
High lncRNA-ATB expression was significantly associated with greater tumor size, depth of tumor invasion, lymphatic invasion, vascular invasion, and lymph node metastasis. Patients of the high-lncRNA-ATB expression group had significantly poorer outcomes than those of the low-expression group. Additionally, levels of lncRNA-ATB expression were significantly higher in patients with hematogenous metastases.


CONCLUSIONS
lncRNA-ATB may be involved in the progression of CRC and be a novel indicator of poor prognosis in patients with CRC.
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Tomohiro
T
Iguchi
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Ryutaro
R
Uchi
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Sho
S
Nambara
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Tomoko
T
Saito
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Hisateru
H
Komatsu
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Hidenari
H
Hirata
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Masami
M
Ueda
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Shotaro
S
Sakimura
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Yuki
Y
Takano
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Jyunji
J
Kurashige
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Yoshiaki
Y
Shinden
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Hidetoshi
H
Eguchi
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
Keishi
K
Sugimachi
Department of Surgery and Science Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan.
Yoshihiko
Y
Maehara
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan kmimori@beppu.kyushu-u.ac.jp.
Koshi
K
Mimori
D015179:Colorectal Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D062085:RNA, Long Noncoding / Q000502:physiology*; D012189:Retrospective Studies
D062085:RNA, Long Noncoding
Long noncoding RNA; TGF-β; colorectal cancer; prognosis; progression