pH-responsive release behavior and anti-bacterial activity of bacterial cellulose-silver nanocomposites.
Bacterial cellulose (BC) has been extensively explored as some of the most promising biomaterials for biomedical applications due to their unique properties, such as high crystallinity, high mechanical strength, ultrafine fiber network structure, good water holding capacity and biocompatibility. However, BC is lack of anti-bacterial activity which is the main issue to be solved. In the study, BC-Ag nanocomposites were prepared in situ by introducing silver nanoparticles (AgNPs) into BC acting as the templates. The BC and as-prepared BC-Ag nanocomposites were characterized by several techniques including scanning electron microscope, Fourier transform infrared spectra, ultraviolet-visible absorption spectra, X-ray diffraction and thermogravimetric analyses. These results indicate AgNPs successfully impregnated into BC. The releases of Ag(+) at different pH values were studied, which showed pH-responsive release behaviors of BC-Ag nanocomposites. The anti-bacterial performances of BC-Ag nanocomposites were evaluated with Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 9372 and Candida albicans CMCC(F) 98001, which frequently causes medical associated infections. The experimental results showed BC-Ag nanocomposites have excellent anti-bacterial activities, thus confirming its utility as potential wound dressings.
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: w.shao@njfu.edu.cn.
Wei
W
Shao
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Hui
H
Liu
College of Life Science, Nanjing University, Nanjing 210093, PR China.
Xiufeng
X
Liu
Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing 210037, PR China.
Haijun
H
Sun
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China.
Shuxia
S
Wang
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: zhangrui@njfu.edu.cn.
Rui
R
Zhang
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D001419:Bacteria / Q000378:metabolism*; D002482:Cellulose / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000648:ultrastructure; D006863:Hydrogen-Ion Concentration; D053761:Nanocomposites / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D012834:Silver; D002482:Cellulose
Anti-bacterial activity; Bacterial cellulose; Silver nanoparticles; pH sensitive release