The Number of Cysteine Residues per Mole in Apolipoprotein E Is Associated With the Severity of PTSD Re-Experiencing Symptoms.
Apolipoprotien E (ApoE) is involved in critical neural functions and is associated with various neuropsychiatric disorders. ApoE exists in three isoforms that differ in the number of cysteine residues per mole (CysR/mole). This study evaluated associations between this informative ordinal biochemical scale (CysR/mole) and symptom severity in veterans with posttraumatic stress disorder (PTSD) or subthreshold PTSD. Results demonstrated a significant negative relationship between the CysR/mole and severity of PTSD re-experiencing symptoms, adjusted for trauma. The findings suggest a genetic influence on PTSD symptomatology and dovetail with recent advances regarding the molecular mechanisms underlying the differential effects of ApoE in the brain.
From the Brain Sciences Center, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN.
Carly K
CK
Peterson
Lisa M
LM
James
Samantha L
SL
Anders
Brian E
BE
Engdahl
Apostolos P
AP
Georgopoulos
D000328:Adult; D000368:Aged; D001057:Apolipoproteins E / Q000737:chemistry / Q000235:genetics*; D003545:Cysteine / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012333:RNA, Messenger; D012720:Severity of Illness Index; D013313:Stress Disorders, Post-Traumatic / Q000235:genetics*; D014728:Veterans
D001057:Apolipoproteins E; D012333:RNA, Messenger; D003545:Cysteine