[The synergistic effect of local microwave hyperthermia and chemotherapy for advanced or recurrent breast cancer].
The purpose of our study was to test the efficacy and toxicity of hyperthermia in conjunction with chemotherapy for breast cancer. Between 2009 and 2014, 6 patients diagnosed with breast carcinoma were selected for this retrospective study. Patients received standard chemotherapy (AC followed by paclitaxel ) in combination with hyperthermia. The hyperthermia device employed microwave heating with water loaded and water-cooled waveguides. The temperature was monitored subcutaneously in the skin under the aperture of the waveguide. Following hyperthermia therapy, 4 patients had a partial response to treatment and the toxicity was mild, consisting of Grade 1 acute skin toxicity. Therefore, hyperthermia combined with chemotherapy for breast cancer seems to be effective and generally tolerable. A larger patient cohort is needed to confirm these results.
Dept. of Breast Surgery, Seiko Hospital.
Chizuko
C
Yamamoto
Daigo
D
Yamamoto
Yu
Y
Tsubota
Noriko
N
Sueoka
Katsuhiro
K
Kawakami
Mitsuo
M
Yamamoto
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008872:Microwaves; D008875:Middle Aged; D009367:Neoplasm Staging; D012008:Recurrence