Serum expression of S100A6 is a potential detection marker in patients with urothelial carcinoma in the urinary bladder.
To investigate the level of serum S100A6 in patients with bladder cancer and in healthy controls and compare these levels with clinicopathologic findings, we evaluated the level of serum S100A6 in 30 healthy controls and 50 patients with bladder cancer diagnosed via transurethral resection of bladder tumor and/or radical cystectomy. S100A6 in sera was detected by employing automatic dot blot systems, and the micro Dot Blot array with a 256-solid pin configuration. The normalized signal of serum S100A6 expression in bladder cancer patients was significantly higher than that of healthy controls (P = 0.001). Serum S100A6 expression of non-muscle-invasive cancer (NMIC) was significantly higher than that of healthy controls (P = 0.04). Furthermore, the S100A6 serum level in patients with muscle-invasive bladder cancer was significantly higher than that in patient with NMIC (P = 0.004). The sensitivity and specificity were 48.0% (95% CI: 0.337-0.626) and 93.3% (95% CI: 0.779-0.992), respectively. The area under the curve was 0.727. Serum S100A6 expression is a potentially effective detection marker for bladder cancer. Applying this serum marker to clinical practice would require less-invasive examinations of patients and would help to detect life-threatening cancerous lesions earlier than current modalities.
Departments of Urology, Kitasato University School of Medicine.
Morihiro
M
Nishi
Kazumasa
K
Matsumoto
Makoto
M
Kobayashi
Kengo
K
Yanagita
Toshihide
T
Matsumoto
Ryo
R
Nagashio
Daisuke
D
Ishii
Tetsuo
T
Fujita
Yuichi
Y
Sato
Masatsugu
M
Iwamura
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D018797:Cell Cycle Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000097:blood*
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D000075383:S100 Calcium Binding Protein A6; D009418:S100 Proteins; C055351:S100A6 protein, human