Innate memory T cells.
Memory T cells are usually considered to be a feature of a successful immune response against a foreign antigen, and such cells can mediate potent immunity. However, in mice, alternative pathways have been described, through which naïve T cells can acquire the characteristics and functions of memory T cells without encountering specific foreign antigen or the typical signals required for conventional T cell differentiation. Such cells reflect a response to the internal rather the external environment, and hence such cells are called innate memory T cells. In this review, we describe how innate memory subsets were identified, the signals that induce their generation and their functional properties and potential role in the normal immune response. The existence of innate memory T cells in mice raises questions about whether parallel populations exist in humans, and we discuss the evidence for such populations during human T cell development and differentiation.
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: james024@umn.edu.
Stephen C
SC
Jameson
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
You Jeong
YJ
Lee
Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA. Electronic address: hogqu001@umn.edu.
Kristin A
KA
Hogquist
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D016207:Cytokines / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000276:immunology; D008231:Lymphopenia / Q000276:immunology; D051379:Mice; D055611:Natural Killer T-Cells / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines
CD8 T cells; Cytokines; Homeostasis; Immune memory; NKT cells