Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity.
Ten members of the mezzettiaside family of natural products were synthesized and evaluated for anticancer and antibacterial activity. Complete anticancer (H460) and antibacterial (B. subtilis) activities for the ten natural products and four new analogues were found. Comparison to the cleistrioside and cleistetroside classes of natural products were made.
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Sumit O
SO
Bajaj
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Pei
P
Shi
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
Penny J
PJ
Beuning
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115.
George A
GA
O'Doherty