Meta-analysis: is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?
OBJECTIVE
To access the efficacy of combination with amoxicillin and tetracycline for eradication of Helicobacter pylori (H. pylori), thus providing clinical practice guidelines.


METHODS
PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Science Citation Index, China National Knowledge Infrastructure, Wanfang, and Chinese Biomedical Literature databases and abstract books of major European, American, and Asian gastroenterological meetings were searched. All clinical trials that examined the efficacy of H. pylori eradication therapies and included both tetracycline and amoxicillin in one study arm were selected for this systematic review and meta-analysis. Statistical analysis was performed with Comprehensive Meta-Analysis Software (Version 2). Subgroup, meta-regression, and sensitivity analyses were also carried out.


RESULTS
Thirty-three studies met the inclusion criteria. The pooled odds ratio (OR) was 0.90 (95%CI: 0.42-1.78) for quadruple therapy with amoxicillin and tetracycline vs other quadruple regimens, and total eradication rates were 78.1% by intention-to-treat (ITT) and 84.5% by per-protocol (PP) analyses in the experimental groups. The pooled eradication rates of 14-d quadruple regimens with a combination of amoxicillin and tetracycline were 82.3% by ITT and 89.0% by PP, and those of 10-d regimens were 84.6% by ITT and 93.7% by PP. The OR by ITT were 1.21 (95%CI: 0.64-2.28) for triple regimens with amoxicillin and tetracycline vs other regimens and 1.81 (95%CI: 1.37-2.41) for sequential treatment with amoxicillin and tetracycline vs other regimens, respectively.


CONCLUSIONS
The effectiveness of regimens employing amoxicillin and tetracycline for H. pylori eradication may be not inferior to other regimens, but further study should be necessary.
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Zhi-Fa
ZF
Lv
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Fu-Cai
FC
Wang
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Hui-Lie
HL
Zheng
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Ben
B
Wang
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Yong
Y
Xie
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Xiao-Jiang
XJ
Zhou
Zhi-Fa Lv, Fu-Cai Wang, Ben Wang, Yong Xie, Xiao-Jiang Zhou, Nong-Hua Lv, Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Nong-Hua
NH
Lv
D000658:Amoxicillin / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D016017:Odds Ratio; D012074:Remission Induction; D012307:Risk Factors; D013752:Tetracycline / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D013752:Tetracycline
Amoxicillin; Helicobacter pylori; Meta-analysis; Systemic review; Tetracycline