Beyond stenosis detection: computed tomography approaches for determining the functional relevance of coronary artery disease.
Coronary computed tomography angiography (CCTA) is an established imaging technique for the noninvasive assessment of coronary arteries. However, CCTA remains a morphologic technique with the same limitations as invasive coronary angiography in evaluating the hemodynamic significance of coronary stenosis. Different computed tomography (CT) techniques for the functional analysis of coronary lesions have recently emerged, including static and dynamic CT myocardial perfusion imaging and CT-based fractional flow reserve and transluminal attenuation gradient methods. These techniques hold promise for achieving a comprehensive appraisal of anatomic and functional aspects of coronary heart disease with a single modality.
Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA; Department of Radiological Sciences, Oncology and Pathology, University of Rome "Sapienza" - Polo Pontino, Via Franco Faggiana 34, Latina 04100, Italy. Electronic address: dececco@musc.edu.
Carlo Nicola
CN
De Cecco
Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA.
Akos
A
Varga-Szemes
Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA; Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital, Marchioninistraße 15, Munich 81377, Germany.
Felix G
FG
Meinel
Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA; Department of Cardiology, Kerckhoff Heart and Thorax Center, Benekestraße 2-8, Bad Nauheim 61231, Germany.
Matthias
M
Renker
Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA; Division of Cardiology, Department of Medicine, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA.
U Joseph
UJ
Schoepf
D000368:Aged; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D055414:Myocardial Perfusion Imaging; D014057:Tomography, X-Ray Computed / Q000379:methods*
Coronary CT angiography; Coronary artery disease; Dual-energy CT; Fractional flow reserve; Myocardial perfusion imaging; Transluminal attenuation gradient