[Association of single nucleotide polymorphisms in the promoter of GABAA receptor β2 subunit gene with schizophrenia].
OBJECTIVE
To investigate the genetic association between schizophrenia and the polymorphism of GABA(A) receptor β2 subunit (GABRB2) gene.


METHODS
A population association analysis was performed of 5 single nucleotide polymorphisms (SNPs) in the proximal promoter of GABRB2 gene by PCR and sequencing of the genomic DNA in a cohort of 172 schizophrenics and 167 controls of Chinese Han nationality.


RESULTS
One out of the 5 SNPs, namely rs3811996, was found to be significantly associated with schizophrenia especially in the male cohorts, where the heterozygous genotypes (A/G) and minor allele G displayed lower frequencies in case group than in the controls.


CONCLUSIONS
We found a new risk, SNP rs3811996, for paranoia schizophrenia, which further supports the importance of genetic variations of GABRB2 in the etiology of schizophrenia.
Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.E-mail: zzzhou1219@163.com.
Lin
L
Zhou
Lu
L
Zong
Lulu
L
Zhang
Cong
C
Deng
Cunyou
C
Zhao
D000483:Alleles; D016022:Case-Control Studies; D005006:Ethnicity; D006579:Heterozygote; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C495710:GABRB2 protein, human; D011963:Receptors, GABA-A