Influence of Hepatic Inflammation on FibroScan Findings in Diagnosing Fibrosis in Patients with Chronic Hepatitis B.
Hepatic inflammation may affect the performance of FibroScan. This prospective study investigated the influence of hepatic inflammation on liver stiffness measurement (LSM) values by assessing FibroScan and liver biopsy findings in 325 patients with chronic hepatitis B. Liver fibrosis and inflammation were classified into five stages (S0-S4) and grades (G0-G4) according to the Scheuer scoring system. LSM values were correlated with fibrosis stage and inflammation grade (r = 0.479, p < 0.001, and r = 0.522, p < 0.001, respectively). Although LSM values increased in parallel with inflammation grade, no significant differences were found between patients with significant fibrosis (S2-S4) (p > 0.05). For inflammation grades G0, G1, G2 and G3, areas under receiver operating characteristic curves of FibroScan for significant fibrosis were 0.8267 (p < 0.001), 0.6956 (p < 0.001), 0.709 (p = 0.0012) and 0.6947 (p = 0.137), respectively. Inflammation has a significant influence on LSM values in patients with chronic hepatitis B with mild fibrosis, but not in those with significant fibrosis.
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Xianghua
X
Zeng
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Cheng
C
Xu
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China; Liver Diagnosis and Treatment Center, 88th Hospital of Chinese People's Liberation Army, Tai'an, Shandong Province, China.
Dengming
D
He
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Huiyan
H
Zhang
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Jie
J
Xia
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Dairong
D
Shi
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Lingjun
L
Kong
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China.
Xiaoqin
X
He
Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China; Chongqing Key Laboratory for Research on Infectious Diseases, Chongqing, China. Electronic address: Wym417@163.com.
Yuming
Y
Wang
D000328:Adult; D054459:Elasticity Imaging Techniques / Q000295:instrumentation / Q000379:methods; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging; D008103:Liver Cirrhosis / Q000150:complications* / Q000000981:diagnostic imaging*; D008297:Male; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results
Chronic hepatitis B; FibroScan; Inflammation; Liver stiffness measurement; Significant liver fibrosis