Computational prediction of riboswitches.
Riboswitches present a ubiquitous genetic regulatory mechanism for prokaryotes and have been found in HIV1, fungi, plants, and even H. sapiens. We present an overview of approaches to predict riboswitch aptamers and, more generally, RNA conformational switches.
Biology Department, Boston College, Boston, Massachusetts, USA. Electronic address: clote@bc.edu.
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D000465:Algorithms; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D000069550:Machine Learning; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D022661:RNA, Untranslated / Q000737:chemistry; D058928:Riboswitch; D012984:Software; D013211:Staphylococcus aureus / Q000235:genetics; D013816:Thermodynamics
D022661:RNA, Untranslated; D058928:Riboswitch
Conformational switch; Machine learning; Noncoding RNA; Riboswitch; Thermodynamics-based algorithm