What really is a concentrated HIV epidemic and what does it mean for West and Central Africa? Insights from mathematical modeling.
BACKGROUND
HIV epidemics have traditionally been classified as "concentrated" among key populations if overall HIV prevalence was below 1% and as "generalized" otherwise. We aimed to objectively determine the utility of this classification by determining how high overall HIV prevalence can reach in epidemics driven by unprotected sex work (SW) and how estimates of the contribution of SW to HIV transmission changes over time in these epidemics.


METHODS
We developed a deterministic model of HIV transmission specific to West and Central Africa to simulate 1000 synthetic HIV epidemics, where SW is the sole behavioral driver that sustains HIV in the population (ie, truly concentrated epidemics), and it is based on a systematic extraction of model parameters specific to West and Central Africa. We determined the range of plausible HIV prevalence in the total population over time and calculated the population attributable fraction (PAF) of SW over different time periods.


RESULTS
In 1988 and 2008, HIV prevalence across the 1000 synthetic concentrated HIV epidemics ranged (5th-95th percentile) between 0.1%-4.2% and 0.1%-2.8%, respectively. The maximum HIV prevalence peaked at 12%. The PAF of SW measured from 2008 over 1 year was <5%-18% compared with 16%-59% over 20 years in these SW-driven epidemics.


CONCLUSIONS
Even high HIV-prevalence epidemics can be driven by unprotected SW and therefore concentrated. Overall, HIV prevalence and the short-term PAF are poor makers of underlying transmission dynamics and underestimate the role of SW in HIV epidemics and thus should not be used alone to inform HIV programs.
*Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom; †Centre de recherche du CHU de Québec, Département de médecine sociale et préventive, Université Laval, Laval, Quebec, Canada; ‡Center for Public Health and Human Rights, Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; §Centre for Global Public Health, Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; ‖School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; and ¶Division of Infectious Diseases, Department of Medicine, St. Michael's Hospital, Li Ka Shing Knowledge Institute, University of Toronto, Toronto, Ontario, Canada.
Marie-Claude
MC
Boily
Michael
M
Pickles
Michel
M
Alary
Stefan
S
Baral
James
J
Blanchard
Stephen
S
Moses
Peter
P
Vickerman
Sharmistha
S
Mishra
D000350:Africa, Central / Q000453:epidemiology; D000354:Africa, Western / Q000453:epidemiology; D017280:Condoms; D058872:Epidemics; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D008954:Models, Biological; D015995:Prevalence; D060386:Sex Workers; D012725:Sexual Behavior; D013997:Time Factors