Extracellular vesicles in Alzheimer's disease: friends or foes? Focus on aβ-vesicle interaction.
The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing attention in Alzheimer's disease (AD). Among other transfer modes, Aβ and tau dissemination has been suggested to occur through release of Extracellular Vesicles (EVs), which may facilitate delivery of pathogenic proteins over large distances. Recent evidence indicates that EVs carry on their surface, specific molecules which bind to extracellular Aβ, opening the possibility that EVs may also influence Aβ assembly and synaptotoxicity. In this review we focus on studies which investigated the impact of EVs in Aβ-mediated neurodegeneration and showed either detrimental or protective role for EVs in the pathology.
CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milano, Italy. pooja.joshii87@gmail.com.
Pooja
P
Joshi
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. lbenussi@fatebenefratelli.it.
Luisa
L
Benussi
Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, via Olgettina 60, 20132 Milano, Italy. furlan.roberto@hsr.it.
Roberto
R
Furlan
Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy. rghidoni@fatebenefratelli.it.
Roberta
R
Ghidoni
CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milano, Italy. c.verderio@in.cnr.it.|IRCCS Humanitas, via Manzoni 56, 20089 Rozzano, Italy. c.verderio@in.cnr.it.
Claudia
C
Verderio
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism; D006801:Humans; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016875:tau Proteins