Anti-tumor activity of a polysaccharide from blueberry.
Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg-1·d-1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. sun_xiyun@163.com.
Xiyun
X
Sun
College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, China. lnbrisk@163.com.
Ning
N
Liu
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. wuzxsau@163.com.
Zhaoxia
Z
Wu
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. fywjg@sina.com.
Ying
Y
Feng
College of Food, Shenyang Agricultural University, 120 Dongling Rd, Shenyang 110866, China. mengxjsy@126.com.
Xianjun
X
Meng
D000818:Animals; D000970:Antineoplastic Agents / Q000276:immunology / Q000494:pharmacology*; D001685:Biological Factors / Q000276:immunology / Q000494:pharmacology*; D029798:Blueberry Plants / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D007155:Immunologic Factors / Q000276:immunology / Q000494:pharmacology; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000276:immunology / Q000494:pharmacology; D011134:Polysaccharides / Q000276:immunology / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000970:Antineoplastic Agents; D001685:Biological Factors; D007155:Immunologic Factors; D007376:Interleukin-2; D010936:Plant Extracts; D011134:Polysaccharides; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma