MicroRNA-503 promotes tumor progression and acts as a novel biomarker for prognosis in oesophageal cancer.
OBJECTIVE
This study investigated microRNA (miR)-503 expression levels and evaluated its clinical significance in patients with oesophageal cancer (EC).


METHODS
miR-503 expression was quantified by quantitative reverse transcription-polymerase chain reaction in 49 EC tissue samples and 12 adjacent normal tissues from 49 patients with EC. The association between miR-503 expression and clinicopathological factors, including prognostic outcomes, were assessed.


RESULTS
miR-503 was found up-regulated in EC tissues compared to adjacent normal tissues. High miR-503 expression was significantly associated with large tumor size. Kaplan-Meier analysis showed that patients with high miR-503 expression had significantly poorer disease-free and overall survival than those with lower expression levels. High miR-503 expression was identified as an independent prognostic predictor in patients with EC according to multivariate analysis.


CONCLUSIONS
miR-503 expression affects tumor cell proliferation in EC. Evaluation of miR-503 expression might thus help identify patients with EC with poor prognosis and higher risk of early recurrence.
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Shozo
S
Ide
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan ytoi0725@clin.medic.mie-u.ac.jp.
Yuji
Y
Toiyama
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Tadanobu
T
Shimura
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Mikio
M
Kawamura
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Hiromi
H
Yasuda
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Susumu
S
Saigusa
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Masaki
M
Ohi
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Koji
K
Tanaka
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Yasuhiko
Y
Mohri
Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
Masato
M
Kusunoki
D014408:Biomarkers, Tumor / Q000032:analysis / Q000502:physiology*; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000032:analysis / Q000502:physiology*; D009364:Neoplasm Recurrence, Local / Q000209:etiology
D014408:Biomarkers, Tumor; C545473:MIRN503 microRNA, human; D035683:MicroRNAs
biomarker; miR-503; oesophageal cancer; prognosis