Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms.
Bariatric surgery is the most effective treatment for severe obesity, producing marked sustained weight loss with associated reduced morbidity and mortality. Roux-en-Y gastric bypass surgery (RYGBP), the most commonly performed procedure, was initially viewed as a hybrid restrictive-malabsorptive procedure. However, over the last decade, it has become apparent that alternative physiologic mechanisms underlie its beneficial effects. RYGBP-induced altered feeding behavior, including reduced appetite and changes in taste/food preferences, is now recognized as a key driver of the sustained postoperative weight loss. The brain ultimately determines feeding behavior, and here we review the mechanisms by which RYGBP may affect central appetite-regulating pathways.
Sean
S
Manning
Andrea
A
Pucci
Rachel L
RL
Batterham
D000713:Anastomosis, Roux-en-Y; D000818:Animals; D001069:Appetite Regulation; D005247:Feeding Behavior; D015390:Gastric Bypass; D006801:Humans; D009765:Obesity / Q000503:physiopathology / Q000601:surgery*; D064887:Observational Studies as Topic; D044105:Receptor, Melanocortin, Type 4 / Q000378:metabolism
D044105:Receptor, Melanocortin, Type 4