Pd-catalyzed asymmetric allylic amination using easily accessible metallocenyl P,N-ligands.
Compared to their C1-symmetric counterparts, planar chiral C2-symmetric metallocenyl P,N-ligands are efficient chiral ligands for Pd-catalyzed asymmetric allylic aminations, providing a number of amination products with high enantioselectivities. A non-C2-symmetric ferrocenyl P,N-ligand (a by-product obtained during the synthesis of the above C2-symmetric species) was also found to be an efficient ligand for asymmetric allylic aminations. A mixed ligand system consisting of both C2- and non-C2-symmetric ferrocene complexes was examined and showed high catalytic activity with the amination products being obtained with excellent enantioselectivities.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
Hongwei
H
Wu
Fang
F
Xie
Yanlan
Y
Wang
Xiaohu
X
Zhao
Delong
D
Liu
Wanbin
W
Zhang
D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D000586:Amination; D002384:Catalysis; D005296:Ferrous Compounds / Q000737:chemistry; D008024:Ligands; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D013237:Stereoisomerism
D000475:Alkenes; D005296:Ferrous Compounds; D008024:Ligands; D000075163:Metallocenes; D009942:Organometallic Compounds; D010720:Phosphines; D010165:Palladium; C004998:ferrocene