In vivo study of novelly formulated porcine-derived fibrinogen as an efficient sealant.
Fibrinogen has been used as surgical sealant in the clinical setting for decades. The application of human plasma-derived fibrinogen is limited due to high cost and the risk of prion and virus infection. We developed a novel arginine-formulated fibrinogen from cryoprecipitates of porcine plasma. This porcine-derived fibrinogen exhibited excellent stability during sterilization and better hemostatic efficacy than a leading commercial hemostatic product in a nonlethal hemorrhage model. Therefore, it has the potential to be more economical and readily available while having a decreased risk of human blood-borne pathogen transmission.
School of Materials Science and Engineering, Shanghai JiaoTong University, Shanghai, China.
Zhang
Z
Liu
Lidong
L
Guan
Kang
K
Sun
Xujun
X
Wu
Ling
L
Su
Jifeng
J
Hou
Miao
M
Ye
Weihong
W
Huang
Hongbing
H
He
D000818:Animals; D002942:Circular Dichroism; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005340:Fibrinogen / Q000737:chemistry*; D008297:Male; D011817:Rabbits; D013552:Swine; D014014:Tissue Adhesives
D014014:Tissue Adhesives; D005340:Fibrinogen