Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy.
Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.
From the *Cardiology Unit, and †Nuclear Medicine Unit, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Bologna; and ‡Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.
Simone
S
Longhi
Rachele
R
Bonfiglioli
Laura
L
Obici
Christian
C
Gagliardi
Agnese
A
Milandri
Massimiliano
M
Lorenzini
Pier Luigi
PL
Guidalotti
Giampaolo
G
Merlini
Claudio
C
Rapezzi
D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000209:etiology; D004164:Diphosphonates; D006801:Humans; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals
D004164:Diphosphonates; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid