Kinetics effects and modeling of mRNA turnover.
Broader comprehension of gene expression regulatory mechanisms can be gained from a global analysis of how transcription and degradation are coordinated to orchestrate complex cell responses. The role of messenger RNA (mRNA) turnover modulation in gene expression levels has become increasingly recognized. From such perspective, in this review we briefly illustrate how a simple but effective mathematical model of mRNA turnover and some experimental findings, may together shed light on the molecular mechanisms underpinning the major role of mRNA decay rates in shaping the kinetics of gene activation and repression.
Institute for Computing Applications "Mauro Picone", National Research Council, Rome, Italy.
Maria Concetta
MC
Palumbo
Lorenzo
L
Farina
Paola
P
Paci
D006207:Half-Life; D007700:Kinetics; D008957:Models, Genetic; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*
D012333:RNA, Messenger