Formulation and in vivo evaluation of diclofenac sodium sustained release matrix tablet: effect of compression force.
In the present study, Diclofenac Sodium (DS) matrix tablets were prepared by direct compression method under different compression forces (5, 10, 15 and 20 KN), using ethylcellulose as matrix forming material. The produced tablets were characterized on the foundation of satisfactory tablet properties such as hardness, friability, drug content, weight variations and in vitro drug release rate. Differential scanning calorimetry (DSC), Fourier Transform Infrared (FT-IR) spectroscopy and X-ray diffraction have been used to investigate any incompatibilities of the tablet's ingredients. Additionally, in vivo bioavailability has been investigated on beagle dogs. Data obtained revealed that, upon increasing compression force the in vitro drug release was sustained and the T(max) value was four hours (for formulations compressed at 15 and 20 kN) compared to the conventional voltarine(®) 50 tablets (T(max) value of 2 hours).
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ehab Ibrahim
EI
Taha
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Gamal Abdel-Ghany
GA
Shazly
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Kayali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University, Saudi Arabia.
Gamaleldin Ibrahim
GI
Harisa
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Nahla Sedik
NS
Barakat
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Fouza Kayem
FK
Al-Enazi
Department of Pharmaceutics, College of Pharmacy, Al-Jouf University, Al-Jouf, Sakaka, Saudi Arabia.
Ibrahim Mostafa
IM
Elbagory
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004285:Dogs; D008297:Male; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D004008:Diclofenac