Acute myocardial infarction: 'telomerasing' for cardioprotection.
Reactivating the telomerase gene through gene therapy after acute myocardial infarction (AMI) has been recently reported to improve survival in mice. Given that regular physical exercise also activates this gene, therapeutic and lifestyle interventions targeting telomerase need to be explored as possible additions to the current armamentarium for myocardial regeneration.
Research Institute, Hospital 12 de Octubre ('i+12'), Avda de Córdoba s/n, 28041 Madrid, Spain. Electronic address: Fabian.sanchis@uv.es.
Fabian
F
Sanchis-Gomar
Research Institute, Hospital 12 de Octubre ('i+12'), Avda de Córdoba s/n, 28041 Madrid, Spain; Universidad Europea and Research Institute, Hospital 12 de Octubre ('i+12'), 28670 Villaviciosa de Odón, Madrid, Spain.
Alejandro
A
Lucia
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods; D051379:Mice; D009043:Motor Activity; D009203:Myocardial Infarction / Q000628:therapy*; D019098:Telomerase / Q000235:genetics* / Q000378:metabolism
D019098:Telomerase
cardiac regeneration; cardioprotection; myocardial infarction; telomerase