Advances in asthma pathophysiology: stepping forward from the Maurizio Vignola experience.
Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe asthma. His observations contributed to define the biology of asthma as we know it today, and opened the way to the personalised treatment of asthma. His group has successfully continued to investigate the biology and clinical aspects of bronchial asthma, with major interest in the clinical use of biomarkers to monitor disease activity, and in the development of new therapeutic perspectives. This review summarises the latest work on these topics proudly conducted by Maurizio's closest collaborators. The results indicate significant progress in our understanding of asthma in the last 10 years, in particular increased knowledge of the complex interaction between inflammatory and remodelling pathways, improved recognition of biological and clinical asthma phenotypes, and development of new treatment strategies, especially for patients with severe corticosteroid-resistant asthma.
Biomedical Dept of Internal and Specialistic Medicine (DiBiMIS), Pneumology, University of Palermo, Palermo, Italy Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy marisa@ibim.cnr.it.
Maria R
MR
Bonsignore
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Mirella
M
Profita
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Rosalia
R
Gagliardo
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Loredana
L
Riccobono
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Giuseppina
G
Chiappara
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Elisabetta
E
Pace
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council (CNR), Palermo, Italy.
Mark
M
Gjomarkaj
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D056151:Airway Remodeling / Q000502:physiology; D001249:Asthma / Q000503:physiopathology* / Q000628:therapy; D015415:Biomarkers / Q000032:analysis; D004351:Drug Resistance; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000503:physiopathology
D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D005938:Glucocorticoids