Hostile takeover: glioma stem cells recruit TAMs to support tumor progression.
The dynamic interaction between cancer cells and immune cells is a critical concern for developing effective tumor immunotherapies. In a recent issue of Nature Cell Biology, Zhou et al. (2015) report that glioma stem cells secrete Periostin (POSTN), which recruits tumor-associated macrophages (TAMs) and supports the tumor-promoting M2 subtype.
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China.
Yu
Y
Shi
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China.
Yi-fang
YF
Ping
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China.
Xia
X
Zhang
Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology of Ministry of Education of China, Third Military Medical University, Chongqing 400038, China. Electronic address: bianxiuwu@263.net.
Xiu-wu
XW
Bian
D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008264:Macrophages / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*
D015815:Cell Adhesion Molecules