Seborrheic keratosis with bowenoid transformation: the immunohistochemical features and its association with human papillomavirus infection.
The bowenoid transformation of seborrheic keratosis (SK) has rarely been reported. The purpose of this study is to identify their diagnostic immunohistochemical features and association with human papillomavirus (HPV) infection. Skin biopsy specimens of the phenomenon were retrieved from 2001 to 2010. Benign SK, Bowen disease, bowenoid papulosis, and squamous cell carcinoma were included as controls. All specimens were stained for hematoxylin and eosin, Ki-67, p21, p16, p53, and cyclin D1. Polymerase chain reaction-amplified HPV DNA was analyzed. Seventeen cases of SK with bowenoid transformation were identified. The immunohistochemical pattern of bowenoid transformation was similar to that of Bowen disease and bowenoid papulosis. The malignant cells exhibited increased expressions of p16, p21, and ki-67 and a decreased expression of cyclin D1 (P < 0.01). HPV DNA was detected in 5 cases of bowenoid transformation. In conclusion, a portion of the cases of SK with bowenoid transformation were associated with HPV infection. Selective immunohistochemical stains were helpful in the diagnosis of malignant change in these cases.
*Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; †Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan; ‡Department of Cosmetic Applications and Management, Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan; and §Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan.
Yu-Hung
YH
Wu
Pa-Fan
PF
Hsiao
Chi-Kuan
CK
Chen
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001913:Bowen's Disease / Q000473:pathology* / Q000821:virology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017492:Keratosis, Seborrheic / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications; D012878:Skin Neoplasms / Q000473:pathology* / Q000821:virology
D014408:Biomarkers, Tumor