L1 gene sequence of a putative novel type human papillomavirus in an immunocompetent patient with glans lichen sclerosus.
The identification of a putative novel type human papillomaviruses (HPV) strain related to HPV-RTRX3 in a subject with penile skin warts and glans lichen sclerosus is reported. A beta-HPV-RTRX3-like strain was detected in a immunocompetent patient with glans lichen sclerosus. HPV screening was performed by PCR in L1 gene. The MY fragment showed 99% nt identity with HPV-RTRX3 and 64.5% nt identity with HPV-37. The remaining part of the L1 gene showed similarity with HPV 80, 15, 17, and 37. Based on the presence of penile lichen sclerosus and the HPV-RTRX3-like strain found in our patient, a potential correlation was hypothesized.
Molecular Virology Unit, Virology and Microbiology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Stefania
S
Paolucci
Loretta
L
Fiorina
Antonio
A
Piralla
Stefano
S
Novati
Nicola
N
Zerbinati
Fausto
F
Baldanti
D000328:Adult; D036022:Capsid Proteins / Q000235:genetics*; D006801:Humans; D007121:Immunocompetence; D018459:Lichen Sclerosus et Atrophicus / Q000276:immunology / Q000821:virology*; D008297:Male; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000276:immunology / Q000821:virology*; D010802:Phylogeny
D036022:Capsid Proteins; C114580:HPV L1 protein, Human papillomavirus; D009856:Oncogene Proteins, Viral