Coupled Simulation of Hemodynamics and Vascular Growth and Remodeling in a Subject-Specific Geometry.
A computational framework to couple vascular growth and remodeling (G&R) with blood flow simulation in a 3D patient-specific geometry is presented. Hyperelastic and anisotropic properties are considered for the vessel wall material and a constrained mixture model is used to represent multiple constituents in the vessel wall, which was modeled as a membrane. The coupled simulation is divided into two time scales-a longer time scale for G&R and a shorter time scale for fluid dynamics simulation. G&R is simulated to evolve the boundary of the fluid domain, and fluid simulation is in turn used to generate wall shear stress and transmural pressure data that regulates G&R. To minimize required computation cost, the fluid dynamics are only simulated when G&R causes significant vascular geometric change. For demonstration, this coupled model was used to study the influence of stress-mediated growth parameters, and blood flow mechanics, on the behavior of the vascular tissue growth in a model of the infrarenal aorta derived from medical image data.
Mechanical Engineering, University of California, 5126 Etcheverry Hall, Berkeley, CA, 94720-1740, USA.
Jiacheng
J
Wu
Shawn C
SC
Shadden
D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology; D003094:Collagen / Q000502:physiology; D003198:Computer Simulation; D004549:Elastin / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D018919:Neovascularization, Physiologic; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D066253:Vascular Remodeling
D003094:Collagen; D004549:Elastin