Relationship between mean platelet volume and retinopathy of prematurity.
OBJECTIVE
We aimed to investigate the association between mean platelet volume (MPV) and the occurrence of type 1 retinopathy of prematurity (ROP).


METHODS
This was a retrospective case-control study. Cases with ROP required laser surgery; controls developed no ROP or stage 1 ROP. Most recent peripheral blood platelet indices before laser (case) and matched age (control) were abstracted. Student's t-test and multivariate logistic regression analysis were used.


RESULTS
A significant difference was found in MPV values between infants with ROP and control groups (10.76 ± 1.27 fl, 10.04 ± 0.91 fl, p = 0.0001). No significant differences were found in the mean platelet counts or MPV/Platelet counts between the two groups (p = 0.4151, p = 0.1460, respectively). There was a 1.94-fold increase in the risk of retinopathy of prematurity (OR:1.94; p = 0.005) as the MPV value increased.


CONCLUSIONS
Elevated MPV is associated with the occurrence of type 1 ROP. A hypothesis is presented concerning the role of platelets as sequester and deliverer angiogenesis regulators during the neovascularization phase of ROP.
Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China. taoyuanchn@163.com.
Yuan
Y
Tao
Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China. dongyu_jl@163.com.
Yu
Y
Dong
Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China.
Cheng-Wei
CW
Lu
Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China.
Wei
W
Yang
Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China.
Qian
Q
Li
D001724:Birth Weight; D001792:Blood Platelets / Q000502:physiology*; D016022:Case-Control Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D063847:Mean Platelet Volume; D010976:Platelet Count; D012178:Retinopathy of Prematurity / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors
Angiogenesis; Infant; Mean platelet volume; Retinopathy of prematurity