Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair.
Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by (60)Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation.
China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Qing
Q
Wang
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Xiaolei
X
Yang
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Ming
M
Ren
Department of Liver, Gall and Pancreas, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Yulin
Y
Hu
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Qiang
Q
Chen
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Lei
L
Xing
Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, Jilin Province, China.
Chunyang
C
Meng
China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
Tiemei
T
Liu
biocompatibility; biomaterials; chitosan; collagen I; gelatin; nerve repair; neural regeneration