Epigenetic Mechanisms of Serotonin Signaling.
Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes. Serotonin is a monoamine that regulates numerous physiological responses including those in the central nervous system. The cardinal signal transduction mechanisms via serotonin and its receptors are well established, but fundamental questions regarding complex interactions between the serotonin system and heritable epigenetic modifications that exert control on gene function remain a topic of intense research and debate. This review focuses on recent advances and contributions to our understanding of epigenetic mechanisms of serotonin receptor-dependent signaling, with focus on psychiatric disorders such as schizophrenia and depression.
†Department of Psychiatry, ‡Department of Neurology, and §Friedman Brain Institute, Icahn School of Medicine at Mount Sinai New York, New York 10029, United States.
Terrell
T
Holloway
†Department of Psychiatry, ‡Department of Neurology, and §Friedman Brain Institute, Icahn School of Medicine at Mount Sinai New York, New York 10029, United States.
Javier
J
González-Maeso
D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D011985:Receptors, Serotonin / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D011985:Receptors, Serotonin; D012701:Serotonin
G protein-coupled receptors (GPCRs); Schizophrenia; antipsychotics; epigenetics; hallucinogens; histone deacetylases (HDACs); lysergic acid diethylamide (LSD); psychosis; serotonin 5-HT2A receptor