Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention.
Graft-versus-host disease (GVHD) is a known risk factor for invasive aspergillosis (IA), but remains poorly studied in relation to Clostridium difficile infection (CDI). We report a case of a 58-years-old patient who developed an IA within a protected room, CDI and GVHD after allogeneic allogeneic peripheral blood stem cell transplantation (PBSCT). Factors associated with this complex condition in patients receiving allogeneic PBSCT need to be identified.
Service d'Hygiène, Epidémiologie et Prévention, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France; Equipe Epidémiologie et Santé Publique, Université de Lyon, Université Lyon 1, France. Electronic address: naghamkhanafer@hotmail.com.
Nagham
N
Khanafer
Service d'Hygiène, Epidémiologie et Prévention, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France.
Antoine
A
Neuraz
Service d'Hygiène, Epidémiologie et Prévention, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France; Equipe Epidémiologie et Santé Publique, Université de Lyon, Université Lyon 1, France.
Thomas
T
Bénet
Service de Réanimation médicale, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France.
Martin
M
Cour
Service Paludisme, Parasites du sang et Mycologie médicale, Groupement hospitalier Nord, Hospices Civils de Lyon, France.
Florence
F
Persat
Service d'Hématologie, Groupement hospitalier Lyon Sud, Hospices Civils de Lyon, France.
Hélène
H
Labussière
Service de Réanimation médicale, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France.
Laurent
L
Argaud
Service d'Hématologie, Groupement hospitalier Lyon Sud, Hospices Civils de Lyon, France.
Mauricette
M
Michallet
Service d'Hygiène, Epidémiologie et Prévention, Groupement hospitalier Edouard Herriot, Hospices Civils de Lyon, France; Equipe Epidémiologie et Santé Publique, Université de Lyon, Université Lyon 1, France.
Philippe
P
Vanhems
D000890:Anti-Infective Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004761:Enterocolitis, Pseudomembranous / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous
D000890:Anti-Infective Agents
Bone marrow transplant; Clostridium difficile infection; Environmental transmission; Graft-versus-host disease; Invasive aspergillosis; Nosocomial