Feeding cancer's sweet tooth: specialized tumour vasculature shuttles glucose in pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal neoplasm characterized by a 'fortress' of thick collagen fibres, abundant myofibroblasts, and paradoxically reduced vascularization compared to normal pancreas. Despite these features, PDAC shows no reduction in the uptake of glucose that fuels tumour cell survival. In new work published in The Journal of Pathology, Saiyin and colleagues have identified a novel adaptation of PDAC tumour endothelium; namely, 'hairy-like' basal microvilli that increase the total vascular surface area and correlate with regions of highest glucose uptake. Since basal microvilli are not present on normal pancreatic blood vessels, their presence may add diagnostic value and blocking their function is a potential new treatment strategy for PDAC. This novel finding of basal microvilli on PDAC endothelium is a striking example of how phenotypic plasticity in tumour blood vessels contributes to tumour growth and progression, independent of conventional modes of angiogenesis.
Department of Cell Biology & Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.|Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.|McAllister Heart Institute, Chapel Hill, NC, USA.
Andrew C
AC
Dudley
Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.|McAllister Heart Institute, Chapel Hill, NC, USA.|Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Victoria L
VL
Bautch
D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000098:blood supply*
endothelial heterogeneity; endothelial plasticity; pancreatic cancer; tumour angiogenesis; tumour endothelial cells; tumour microenvironment