The ezrin-radixin-moesin family of proteins in the regulation of B-cell immune response.
Dynamic reorganization of the cortical cytoskeleton is essential for numerous cellular processes, including B- and T-cell activation and migration. The ezrin-radixin-moesin (ERM) family of proteins plays structural and regulatory roles in the rearrangement of plasma membrane flexibility and protrusions through its members' reversible interaction with cortical actin filaments and the plasma membrane. Recent studies demonstrated that ERM proteins not only are involved in cytoskeletal organization but also offer a platform for the transmission of signals in response to a variety of extracellular stimuli through their ability to cross-link transmembrane receptors with downstream signaling components. In this review, we summarize present knowledge relating to ERMs and recent progress made toward elucidating a novel role for them in the regulation of B-cell function in health and disease.
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Debasis
D
Pore
Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Neetu
N
Gupta
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002465:Cell Movement; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral; D056747:Immunomodulation; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000378:metabolism*; D008840:Microfilament Proteins / Q000378:metabolism*; D020239:Receptor Cross-Talk; D015398:Signal Transduction; D000099149:Ezrin
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D000099149:Ezrin; C071058:moesin; C071776:radixin