NOTCH3 gene polymorphism is associated with the prognosis of gliomas in Chinese patients.
Recent studies show that NOTCH3 is involved in the glioma development and it is also a prognostic factor for glioma patients. However, the gene polymorphism of NOTCH3 in gliomas prognosis remains unknown.A total of 266 patients were enrolled into this study. The NOTCH3 gene polymorphism at 3 loci, including C>T polymorphism at nucleotide 381, C>A polymorphism at 474 and G>A polymorphism at 684 were determined. All patients received the surgical treatment and/or chemotherapy and/or radiotherapy.We found that the 684G>A polymorphism affects the tumor NOTCH3 expression level and is closely associated with a higher tumor grade, poorer tumor differentiation, and karnofsky performance score in these glioma patients. More importantly, the 684G>A polymorphism is significantly associated with the prognosis of these patients regardless of their treatment manner.Our study indicates that the NOTCH3 gene 684G>A polymorphism may be used as a prognosis marker for gliomas.
From the Department of Neurosurgery, Children's Hospital, Zhejiang University School of Medicine, 57 Zhugan Lane, Hangzhou 310003, P.R. China (ZS); Hangzhou people hospital, Huansha Road 261, Hangzhou 310006, P.R.China (XH); Department of Rehabilitation, Hangzhou Hospital of Zhejiang Corps, Chinese People's Armed Police Forces, 86 Jiangnan Avenue, Hangzhou 310051, P.R. China (BC); Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, P.R. China (PC); Department of Cardiology, Children's Hospital; Zhejiang University School of Medicine, 57 Zhugan Lane, Hangzhou 310003, P.R. China (QZ).
Zhipeng
Z
Shen
Xuwei
X
Hou
Bo
B
Chen
Peng
P
Chen
Qing
Q
Zhang
D044466:Asian People / Q000235:genetics*; D015415:Biomarkers; D002681:China; D003131:Combined Modality Therapy; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D006801:Humans; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D011379:Prognosis; D000071656:Receptor, Notch3; D051880:Receptors, Notch / Q000235:genetics*
D015415:Biomarkers; C499374:NOTCH3 protein, human; D000071656:Receptor, Notch3; D051880:Receptors, Notch