Improvement of interaction between PVA and chitosan via magnetite nanoparticles for drug delivery application.
Magnetite nanoparticles were synthesized by coprecipitation under ultrasonication followed by coating with chitosan. Polyvinyl alcohol (PVA) is then combined with the chitosan that coated the magnetite nanoparticles. The combination occurs by hydrogen binding and ionic cross-linking of the amino and hydroxyl groups of chitosan and PVA respectively. The magnetite nanoparticles have an average size of 10.62 nm that was confirmed by TEM. The VSM measurements showed that nanoparticles were superparamagnetic. The coatings on the core nanoparticles were estimated by AAS and the attachments of coating to the nanoparticles were confirmed by FT-IR analysis. Physicochemical properties of nanoparticles were measured by DLS and zeta potential. Naked magnetite, chitosan and PVA coating have zeta potential of +36.4, +48.1 and -12.5 mV respectively. The unspecific adsorption and interaction between nanoparticles and bovine serum albumin (BSA) were investigated systematically by UV-vis spectroscopy method. The nanoparticles that were modified by PVA present low protein adsorption, which makes them a practical choice for preventing opsonization in clinical application and drug delivery.
Institute of Nanoscience and Nanotechnology, University of Kashan, Kashan, Islamic Republic of Iran.
Hamidreza
H
Shagholani
Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Islamic Republic of Iran. Electronic address: s.m.ghoreishi@kashanu.ac.ir.
Sayed Mehdi
SM
Ghoreishi
Polymer Chemistry Department, School of Science, University of Tehran, Tehran, Islamic Republic of Iran.
Mohammad
M
Mousazadeh
D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry*; D016503:Drug Delivery Systems; D006860:Hydrogen Bonding; D007477:Ions; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012710:Serum Albumin, Bovine; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D007477:Ions; D058185:Magnetite Nanoparticles; D012710:Serum Albumin, Bovine; D011142:Polyvinyl Alcohol; D048271:Chitosan
Bovine serum albumin; Chitosan; Drug delivery; Magnetite nanoparticles; Polyvinyl alcohol