[Effects of amyloid-β peptide Aβ(25-35) on glycolytic and antioxidant enzymes of different ages].
Amyloid-β peptide Aβ(25-35) was shown to cause lysis of rat erythrocytes of different ages. The toxicity of Aβ(25-35) positively correlated with both the erythrocyte age andthe peptide concentration. The activity of glycolytic, antioxidant, and Na+/K(+)-ATPase enzymes decreased with erythrocyte aging in vivo. In vitro Aβ(25-35) reduced the activity of hexokinase, phosphofructokinase, pyruvate kinase, glutathione peroxidase, and glutathione transferase and increased Na+/K(+)-ATPase activity in aged erythrocytes to a greater degree than in young cells.
L A
LA
Tikhonova
Iu G
IuG
Kaminskiĭ
E A
EA
Kosenko
D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage*; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis*
D016229:Amyloid beta-Peptides; D000254:Sodium-Potassium-Exchanging ATPase