Tilt after-effect from high spatial-frequency patterns in the amblyopic eye of adults with anisometropic amblyopia.
With abnormal visual cortical development, amblyopia is generally associated with high spatial frequency deficits in spatial vision. In this study, we aim to answer a critical question: How much high spatial frequency information is available to the amblyopic visual system? We measured the tilt after-effect following adaption to perceptually resolvable and unresolvable sinewave gratings, and showed that gratings with spatial frequency up to 1.5 times the cutoff frequency in grating orientation identification can still produce significant tilt after-effects in adults with amblyopia. Our results suggest that neural connections in the amblyopic visual cortex, at least in V1, may have profoundly developed to represent high spatial frequency information. The demonstration of extant neural connections for high spatial frequencies may have important implications for the development of training protocols for amblyopia treatment. Our paradigm may also serve as a non-invasive probe to diagnose the status of neural connections in other visual deficits.
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang Dist., Beijing, 100101, China.
Jiawei
J
Zhou
CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, 230027, Hefei.
Lin
L
Li
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang Dist., Beijing, 100101, China.
Pan
P
Zhang
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang Dist., Beijing, 100101, China.
Jie
J
Xi
CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, 230027, Hefei.
Yifeng
Y
Zhou
Laboratory of Brain Processes (LOBES), Center for Cognitive and Brain Sciences, Departments of Psychology, The Ohio State University, Columbus, OH, 43210, United States of America.
Zhong-Lin
ZL
Lu
Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang Dist., Beijing, 100101, China.
Chang-Bing
CB
Huang
D000293:Adolescent; D000550:Amblyopia / Q000503:physiopathology*; D015350:Contrast Sensitivity / Q000502:physiology; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009949:Orientation / Q000502:physiology*; D010775:Photic Stimulation; D010865:Pilot Projects; D014792:Visual Acuity / Q000502:physiology*; D014793:Visual Cortex / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult