The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher.
In June 2014 Dr. Joseph D. Fenstermacher celebrated his 80th birthday, which was honored by the symposium held in New London, NH, USA. This review discusses Fenstermacher's contribution to the field of fluids and barriers of the CNS. Specifically, his fundamental work on diffusion of molecules within the brain extracellular space and the research on properties of the blood-brain barrier in health and disease are described. Fenstermacher's early research on cerebrospinal fluid dynamics and the regulation of cerebral blood flow is also reviewed, followed by the discussion of his more recent work involving the use of magnetic resonance imaging.
Department of Emergency Medicine, Neurotrauma and Brain Barriers Research Laboratory, The Warren Alpert Medical School of Brown University, Coro Center West, Room 112, 1 Hoppin Street, Providence, RI 02903 USA.
Adam
A
Chodobski
Blood-Brain Interface Group, Oncoflam Team and BIP Platform INSERM U 1028, CNRS UMR5292 Lyon Neuroscience Research Center, Faculté de Médecine RTH Laennec, Rue Guillaume Paradin, Cedex 08, 69372 Lyon, France.
Jean-François
JF
Ghersi-Egea
Department of Neuroscience and Physiology, NYU School of Medicine, MSB 460, 550 First Avenue, New York, NY 10016 USA.
Charles
C
Nicholson
Department of Anesthesiology, Henry Ford Hospital, 2799 West Grand Blvd., Detroit, MI 48202-2689 USA.
Tavarekere N
TN
Nagaraja
Department of Emergency Medicine, Neurotrauma and Brain Barriers Research Laboratory, The Warren Alpert Medical School of Brown University, Coro Center West, Room 112, 1 Hoppin Street, Providence, RI 02903 USA.
Joanna
J
Szmydynger-Chodobska
Brain extracellular space; Cerebral blood flow; Cerebrospinal fluid; Diffusion; MRI contrast agent; Radiolabelled tracers; Tumour therapy; Ventriculocisternal perfusion