Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats.
Depression is a predictor of poor prognosis in patients with heart failure. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) may improve these outcomes. Left ventricular volume overload induced hypertrophy that is associated with aortic regurgitation (AR) leads to ventricular dysfunction and heart failure. The aim of this study was to verify the effects of the SSRI paroxetine on cardiac function, as well as on fluid intake and excretion, in subchronic AR. Male Wistar rats (260 to 280g) received sham (SH) surgery or AR induced by retrograde puncture of the aortic valve leaflets. The presence of AR was confirmed by echocardiography (ECHO) exams. Four weeks after AR surgery, subcutaneous injections of paroxetine (PAR: 10mg/kg 3 times in a week) or saline were administered. The rats were randomly divided into the following 4 groups and treated for 4 weeks: AR-PAR, ARsaline, SH-PAR and SH-saline. At the end of the treatment period, fractional shortening was preserved in AR-PAR, compared to AR-saline (46.6±2.7% vs 38.3±2.2%, respectively). Daily 0.3 M NaCl intake was reduced in PAR-treated rats. Natriuresis was increased in weeks 2-3 after PAR treatment. Our results suggest that augmentation of central 5-HT neurotransmission has a beneficial effect on cardiovascular remodeling following volume overload. The mechanisms underlying this effect are unknown.
Department of Physiology, Institute of Bioscience, UNESP-Botucatu, Brazil. Electronic address: jdegobbi@ibb.unesp.br.
Juliana Irani Fratucci
JI
De Gobbi
Department of Physiology, Institute of Bioscience, UNESP-Botucatu, Brazil.
Ana Carolina Mieko
AC
Omoto
Department of Physiology, Institute of Bioscience, UNESP-Botucatu, Brazil.
Tamires Ferreira
TF
Siqueira
Department of Internal Medicine, Botucatu Medical School, UNESP, Brazil.
Luiz Shigueto
LS
Matsubara
Department of Internal Medicine, Botucatu Medical School, UNESP, Brazil.
Meliza Goi
MG
Roscani
Department of Internal Medicine, Botucatu Medical School, UNESP, Brazil.
Beatriz Bojikian
BB
Matsubara
D000704:Analysis of Variance; D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D003863:Depression / Q000188:drug therapy* / Q000209:etiology*; D004195:Disease Models, Animal; D004326:Drinking / Q000502:physiology; D004452:Echocardiography; D006339:Heart Rate / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D017374:Paroxetine / Q000627:therapeutic use*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000378:metabolism*; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine; D012965:Sodium Chloride; D011188:Potassium
Antidepressants; Aortic regurgitation; Serotonin; Sodium intake; Systolic function; Volume overload