Differences in functional brain connectivity alterations associated with cerebral amyloid deposition in amnestic mild cognitive impairment.
Despite potential implications for the early detection of impending Alzheimer's disease (AD), very little is known about the differences of large-scale brain networks between amnestic mild cognitive impairment (aMCI) with high cerebral amyloid-beta protein (Aβ) deposition (i.e., aMCI+) and aMCI with no or very little Aβ deposition (i.e., aMCI-). We first aimed to extend the current literature on altering intrinsic functional connectivity (FC) of the default mode network (DMN) and salience network (SN) from cognitively normal (CN) to AD dementia. Second, we further examined the differences of the DMN and the SN between aMCI-, aMCI+, and CN. Forty-three older adult (12 CN, 10 aMCI+, 10 aMCI-, and 11 AD dementia) subjects were included. All participants received comprehensive clinical and neuropsychological assessment, resting-state functional magnetic resonance imaging, structural MRI, and Pittsburgh compound-B-PET scans. FC data were preprocessed using multivariate exploratory linear optimized decomposition into independent components of FMRIB's Software Library. Group comparisons were carried out using the "dual-regression" approach. In addition, to verify presence of gray matter volume changes with intrinsic functional network alterations, voxel-based morphometry was performed on the acquired T1-weighted data. As expected, AD dementia participants exhibited decreased FC in the DMN compared to CN (particularly in the precuneus and cingulate gyrus). The degree of alteration in the DMN in aMCI+ compared to CN was intermediate to that of AD. In contrast, aMCI- exhibited increased FC in the DMN compared to CN (primarily in the precuneus) as well as aMCI+. In terms of the SN, aMCI- exhibited decreased FC compared to both CN and aMCI+ particularly in the inferior frontal gyrus. FC within the SN in aMCI+ and AD did not differ from CN. Compared to CN, aMCI- showed atrophy in bilateral superior temporal gyri whereas aMCI+ showed atrophy in right precuneus. The results indicate that despite the similarity in cross-sectional cognitive features, aMCI- has quite different functional brain connectivity compared to aMCI+.
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Dahyun
D
Yi
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Young Min
YM
Choe
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Min Soo
MS
Byun
Department of Neuropsychiatry, Seoul Metropolitan Boramae Medical Center , Seoul , South Korea.
Bo Kyung
BK
Sohn
Division of Natural Medical Sciences, College of Health Science, Chosun University , Gwangju , South Korea.
Eun Hyun
EH
Seo
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Jiyoung
J
Han
Department of Biomedical Engineering, Hanyang University , Seoul , South Korea.
Jinsick
J
Park
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Jong Inn
JI
Woo
Department of Neuropsychiatry, Clinical Research Institute, Seoul National University Hospital , Seoul , South Korea.
Dong Young
DY
Lee
amnestic mild cognitive impairment; amyloid-beta deposition; brain functional connectivity; default mode network; salience network