Survivin small interfering RNA suppresses glioblastoma growth by inducing cellular apoptosis.
A survivin small interfering RNA sequence specific for a human and mouse homogenous sequence was constructed. Survivin small interfering RNA could significantly inhibit glioma cell proliferation and induce apoptosis when it was transfected into either a human glioma cell line U251 or rat glioma C6 cells in vitro. In addition, treatment of rat orthotopic glioma models with survivin small interfering demonstrated the inhibition of glioma growth in vivo. Our experimental findings suggest that the use of RNA interference techniques to target the survivin sequence may be useful in the treatment of glioma.
Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China.
Yanbo
Y
Liu
Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China.
Chunming
C
Miao
Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China.
Zhenjiang
Z
Wang
Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China.
Xin
X
He
Beihua University Faculty of Medicine, Jilin 132013, Jilin Province, China.
Weigao
W
Shen
RNA interference; apoptosis; glioblastoma; survivin