CC16 gene A38G polymorphism and susceptibility to asthma: an updated meta-analysis.
OBJECTIVE
To comprehensively evaluate the association between the CC16 gene A38G polymorphism and the risk of asthma.


METHODS
Studies were retrieved from databases including PubMed, EMBASE, Web of Science and the Chinese Biomedical Literature Database according to the inclusive and exclusive criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associations.


METHODS
Fifteen case-control studies with 1,623 cases and 3,294 controls were recruited for the analysis of the association between the CC16 gene A38G polymorphism and the risk of asthma.


RESULTS
The overall ORs showed no significant associations between the CC16 gene A38G polymorphism and the risk of asthma (AA vs. GG: OR=1.04, 95%CI=0.86-1.25; AG vs. GG: OR=1.08, 95%CI=0.94-1.24; AA + AG vs. GG: OR=1.07, 95%CI=0.94-1.22; AA vs. AG + GG: OR=1.01, 95%CI=0.85-1.19; A vs. G: OR=1.04, 95%CI=0.95-1.14). Moreover, similar results were obtained in the subgroup analysis stratified by ethnicity (Asian: AG vs. GG: OR=1.02, 95%CI=0.87-1.21; Caucasian: AG vs. GG: OR=1.22, 95%CI=0.94-1.57) and age (Child: AG vs. GG: OR=1.21, 95%CI=0.84-1.74; Adult: AG vs. GG: OR=1.06, 95%CI=0.91-1.23).


CONCLUSIONS
CC16 gene A38G polymorphism is not associated with the risk of asthma.
Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory of Respiratory Diseases, Ministry of Health, China.
Dan
D
Cheng
Honghong
H
Di
Zheng
Z
Xue
Guohua
G
Zhen
D000328:Adult; D000367:Age Factors; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014598:Uteroglobin / Q000235:genetics*; D044465:White People / Q000235:genetics
C556389:SCGB1A1 protein, human; D014598:Uteroglobin