The association of plasma vitamin A and E levels with coronary collateral circulation.
OBJECTIVE
To investigate if plasma levels of vitamin A and E have an association with coronary collateral development.


METHODS
A total of 189 patients who underwent coronary angiography and had total occlusion in at least one major epicardial coronary artery were enrolled in the study. To classify coronary collateral circulation (CCC), the Rentrop scoring system was used. Patients were classified as having poor CCC (Rentrop grades 0-1) or good CCC (Rentrop grades 2-3), and all patients were also screened for hypertension, hypercholesterolemia, diabetes, and smoking history.


RESULTS
There were no differences in plasma vitamin A and E levels between the two groups (vitamin A: 2.37 ± 0.65 vs. 2.35 ± 0.78, p = 0.253; vitamin E: 47.1 ± 12.8 vs. 44.6 ± 15.1, p = 0.082), and plasma vitamin A and E levels were not associated with CCC. Serum high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher in patients with poor CCC (4.68 ± 2.52 vs. 3.89 ± 1.78, p = 0.001). The higher frequency of diabetes and higher serum hs-CRP levels were found to be an independent predictor for poor CCC (odds ratio = 2.44, p = 0.006; odds ratio = 1.24, p = 0.007, respectively). And a higher frequency of total occluded RCA was found to be a positive predictor for good CCC (odds ratio = 2.36, p = 0.06) in a multivariate logistic regression analysis.


CONCLUSIONS
We found that serum hs-CRP levels, presence of diabetes, and total occlusion of RCA have an effect on coronary collateral development. We found no correlation between plasma vitamin A and E levels and CCC.
Izmir Kâtip Çelebi University, Faculty of Medicine, Department of Biochemistry, Izmir, Turkey. Electronic address: erkanchems@yahoo.com.
Erkan
E
Söğüt
Gaziosmanpaşa University, Faculty of Medicine, Department of Cardiology, Tokat, Turkey.
Hasan
H
Kadı
Gaziosmanpaşa University, Faculty of Medicine, Department of Cardiology, Tokat, Turkey.
Metin
M
Karayakalı
Gaziosmanpaşa University, Faculty of Medicine, Department of Biochemistry, Tokat, Turkey.
Cuma
C
Mertoğlu
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016009:Chi-Square Distribution; D003097:Collateral Circulation; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003326:Coronary Circulation; D054059:Coronary Occlusion / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012307:Risk Factors; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D015415:Biomarkers; D014801:Vitamin A; D014810:Vitamin E; D002097:C-Reactive Protein
Coronary collateral circulation; Vitamin A; Vitamin E