[A case of metastatic rectal cancer with fulminant hepatitis caused by XELOX therapy].
We report a case of fulminant hepatitis that was caused by XELOX therapy administered for metastatic rectal cancer. A 69- year-old man with metastatic rectal cancer received 4 courses XELOX therapy. He was subsequently admitted to our hospital with general fatigue. Shenzhen flapping and altered consciousness were noticed on the fifth day of hospitalization. A liver biopsy was subsequently performed. The patient was diagnosed with liver failure due to sinusoidal obstruction syndrome caused by oxaliplatin. This case provides valuable information as there are only a few reports of fulminant hepatitis caused by oxaliplatin.
Dept. of Gastroenterology, Saiseikai Yokohamashi Tobu Hospital.
Takeshi
T
Kemmochi
Yuta
Y
Suzuki
Masataka
M
Yoneda
Yasuhiro
Y
Ito
Yusuke
Y
Ohkubo
Tomohisa
T
Egawa
Atsushi
A
Nagashima
Reiko
R
Shimokawa
Hiroyuki
H
Makino
Wataru
W
Yamamuro
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives*; D006505:Hepatitis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010071:Oxaloacetates; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology
D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil