MR-based computational fluid dynamics with patient-specific boundary conditions for the initiation of a sidewall aneurysm of a basilar artery.
We performed 3-dimensional cine phase-contrast magnetic resonance-based computational fluid dynamics for a basilar artery that developed a sidewall aneurysm over a 25-month period. There was an area with high gradient oscillatory number in the location of the future aneurysm ostium and an area with high wall shear stress (WSS) and high spatial WSS gradient at the distal edge of the future aneurysm. These could be biomarkers for development of intracranial aneurysms.
Brain & Mind Research Center, Nagoya University, Higashi-ku, Nagoya, Aichi, Japan; Department of Brain & Mind Sciences, Nagoya University Graduate School of Medicine.  isoda@met.nagoya-u.ac.jp
Haruo
H
Isoda
Yasuo
Y
Takehara
Takashi
T
Kosugi
Masaki
M
Terada
Takehiro
T
Naito
Yuki
Y
Onishi
Chiharu
C
Tanoi
Kenji
K
Amaya
Harumi
H
Sakahara
D000369:Aged, 80 and over; D001488:Basilar Artery / Q000473:pathology*; D001696:Biomechanical Phenomena; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D018056:Hemorheology; D006801:Humans; D057446:Hydrodynamics; D021621:Imaging, Three-Dimensional / Q000379:methods*; D002532:Intracranial Aneurysm / Q000175:diagnosis*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D013314:Stress, Mechanical