The processing of chitosan and its derivatives and their application for postoperative anti-adhesion.
The formation of peritoneal adhesions represents one of the most common complications after abdominal surgery, and it increases the difficulty of re-operation. Thus, preventing postoperative adhesions is a major problem in the field of surgical medicine. Due to a lack of good predictive animal models and the complexity of adhesion pathogenesis, attempts to prevent or reduce peritoneal adhesions have been largely unsuccessful. As a result, the study of anti-adhesion drugs and materials has become a hot topic for experts and scholars. The processing and development of chitosan and its derivatives as new anti-adhesion materials is highly valued because chitosan is inexpensive, highly biocompatible, and not cytotoxic, making it a promising anti-adhesion material. Here, we review the sources and preparation of chitosan and the progress made toward producing different types of chitosan and its derivatives for preventing adhesion.
Lin
L
Zhu
Lin
L
Peng
Silk Biotechnology Laboratory, School of Basic Medical and Biological Sciences, Soochow University; No. 199, 702-2303 Room, Renai Road, Dushuhu Higher Edu. Town, Suzhou 215123, P.R China. sericult@suda.edu.cn.
Yu-Qing
YQ
Zhang
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D004339:Drug Compounding; D011183:Postoperative Complications / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control
D001672:Biocompatible Materials; D048271:Chitosan