[Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy].
OBJECTIVE
Interleukin-6 (IL-6) is a predictor of trauma severity. The purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma IL-6 after hysterectomy.


METHODS
A prospective, randomized, comparative, double-blind study with 40 patients, aged 18-60 years. G1 received lidocaine (2mg.kg(-1).h(-1)) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24hours), first analgesic request, and dose of morphine in 24hours were evaluated. IL-6 was measured before starting surgery (T0), five hours after the start (T5), and 24hours after the end of surgery (T24).


RESULTS
There was no difference in pain severity between groups. There was a decrease in pain severity between T0 and other measurement times in G1. Time to first supplementation was greater in G2 (76.0±104.4min) than in G1 (26.7±23.3min). There was no difference in supplemental dose of morphine between G1 (23.5±12.6mg) and G2 (18.7±11.3mg). There were increased concentrations of IL-6 in both groups from T0 to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5±364.1 ng.mL(-1) in T5 and 30.1±14.2 ng.mL(-1) in T24.


CONCLUSIONS
Intravenous lidocaine (2mg.kg(-1).h(-1)) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy.
Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil; Serviço de Dor do Hospital São Domingos (HSD), São Luís, MA, Brasil; Sociedade de Anestesiologia do Estado do Maranhão (Saem), São Luís, MA, Brasil.
Caio Marcio Barros de
CM
Oliveira
Setor de Dor do Departamento de Anestesiologia, Dor e Terapia Intensiva da Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil. Electronic address: riokoks.dcir@epm.br.
Rioko Kimiko
RK
Sakata
Departamento de Anestesiologia, Associação Paulista de Medicina, São Paulo, SP, Brasil.
Alexandre
A
Slullitel
Departamento de Infectologia, Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
Reinaldo
R
Salomão
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brasil.
Vera Lucia
VL
Lanchote
Setor de Dor do Departamento de Anestesiologia, Dor e Terapia Intensiva da Universidade Federal de São Paulo (Unifesp), São Paulo, SP, Brasil.
Adriana Machado
AM
Issy
Dor pós‐operatória; Histerectomia; Hysterectomy; Interleucina‐6; Interleukin‐6; Intravenously; Lidocaine; Lidocaína; Postoperative pain; Via venosa