Human herpes simplex virus: life cycle and development of inhibitors.
WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. kukhan86@hotmail.com.
M K
MK
Kukhanova
A N
AN
Korovina
S N
SN
Kochetkov
D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D016679:Genome, Viral; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014771:Virion / Q000648:ultrastructure; D014779:Virus Replication
D000998:Antiviral Agents