Genetic association between the HLA-G 14-bp insertion/deletion polymorphism and the recurrent spontaneous abortions in Saudi Arabian women.
The non-classical class I human leukocyte antigen (HLA)-G molecule was found to be predominately expressed in the extravillous cytotrophoblasts at the fetal-maternal interface during pregnancy. This molecule is critically important for successful implantation during human pregnancy. The polymorphic insertion-deletion (indel) 14-base pair (bp) site localized at the 3' untranslated region was associated with HLA-G mRNA stability and isoform alternative splicing patterns, and thus may influence HLA-G function during pregnancy. We studied the association between the 14-bp indel polymorphism (rs16375) at the 3' untranslated region with recurrent spontaneous abortions in a Saudi population living in Riyadh. A group of 64 women with 2-11 successive abortions were included in this study. The control group included 62 women without reported abortions and at least 2 pregnancies, all visiting the King Khaled Hospital in Riyadh. The 14-bp indel was genotyped in the case and control groups. The frequency of the genotype +14/+14 was slightly higher in women with recurrent spontaneous abortions, but no significant differences were observed in the distribution of alleles and genotypes.
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
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Al Omar
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia lamjed.mansour@gmail.com.
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Mansour
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
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Alkhuriji
Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
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Alwasel
Depatment of Physiology, College of Medicine, Jazan University, Saudi Arabia.
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Al-Qahtani
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000483:Alleles; D020029:Base Pairing / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059951:HLA-G Antigens / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy
D059951:HLA-G Antigens