[Primary infection and pulmonary tuberculosis].
Tuberculosis is a major public health problem worldwide. Indeed, a third of the world population is infected with Mycobacterium tuberculosis and more than 8 million new cases of tuberculosis each year. Pulmonary tuberculosis is the most common location. Its diagnosis is difficult and often established with a delay causing a spread of infection. The diagnosis of tuberculosis infection is mainly based on immunological tests represented by the tuberculin skin test and detection of gamma interferon, while the diagnosis of pulmonary tuberculosis is suspected on epidemiological context, lasting general and respiratory symptoms, contrasting usually with normal lung examination, and a chest radiography showing suggestive lesions. The radioclinical feature may be atypical in patients with extreme ages and in case of immunodeficiency. Confirmation of tuberculosis is bacteriological. Conventional bacteriological methods remain the reference. Innovative tests using the technique of molecular biology have improved the diagnosis of tuberculosis in terms of sensitivity and especially speed. However, those techniques are of limited use.
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
S
S
Toujani
Service de pneumologie-allergologie, CHU Mongi-Slim (faculté de médecine de Tunis, université de Tunis-El-Manar), 2070 Sidi Daoud, La Marsa, Tunisie.
N
N
Ben Salah
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
J
J
Cherif
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
M
M
Mjid
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
Y
Y
Ouahchy
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
H
H
Zakhama
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
J
J
Daghfous
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
M
M
Beji
Unité de recherche 12SP06, service de pneumologie-allergologie, CHU La-Rabta (faculté de médecine de Tunis, université de Tunis El Manar), 1007 Tunis, Tunisie.
N
N
Mehiri-Ben Rhouma
Service de pneumologie-allergologie, CHU Mongi-Slim (faculté de médecine de Tunis, université de Tunis-El-Manar), 2070 Sidi Daoud, La Marsa, Tunisie. Electronic address: bechir.louzir@gmail.com.
B
B
Louzir
D000995:Antitubercular Agents / Q000627:therapeutic use; D057210:Delayed Diagnosis; D014943:Global Health; D006801:Humans; D015994:Incidence; D059425:Interferon-gamma Release Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014374:Tuberculin Test / Q000379:methods; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology
D000995:Antitubercular Agents
Diagnosis; Diagnostic; Interferon gamma; Interféron gamma; Mycobacterium tuberculosis; Primary infection; Primoinfection; Test cutané tuberculinique; Tuberculin skin test; Tuberculose; Tuberculosis