Association between the PPARGC1A polymorphism and aerobic capacity in Japanese middle-aged men.
OBJECTIVE
A lower frequency for the peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A) Ser482 allele has been reported in elite-level endurance athletes among Caucasians, although this gene polymorphism has not been found to be associated with aerobic capacity in German, Dutch or Chinese populations. The purpose of the current study was to examine the associations between the Gly482Ser polymorphism and aerobic fitness in 112 Japanese middle-aged men.


METHODS
The PPARGC1A Gly482Ser polymorphism was identified according to a TaqMan(®) SNP genotyping assay. Habitual physical activity was objectively measured using an accelerometer. The lactate threshold (LT), an index of aerobic fitness, was measured based on a submaximal graded exercise test performed on an electric cycle ergometer. The association between the LT and the Gly482Ser polymorphism was assessed according to a multiple regression analysis and analysis of covariance, with adjustment for potential confounders (age, body mass index, cigarette smoking, physical activity level and regular exercise).


RESULTS
A significant association was observed between the PPARGC1A Gly482Ser polymorphism and LT, as carriers of the Ser482 had higher LT values than the Gly482 carriers.


CONCLUSIONS
The current results suggest that the PPARGC1A Ser482 allele is associated with a higher aerobic capacity in Japanese middle-aged men.
Department of Preventive Medicine, Faculty of Medicine, Saga University, Japan.
Yuichiro
Y
Nishida
Minako
M
Iyadomi
Yasuki
Y
Higaki
Hiroaki
H
Tanaka
Yoshiaki
Y
Kondo
Hiromi
H
Otsubo
Mikako
M
Horita
Megumi
M
Hara
Keitaro
K
Tanaka
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D017079:Exercise Tolerance / Q000235:genetics*; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000235:genetics*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010809:Physical Fitness / Q000502:physiology; D011110:Polymorphism, Genetic; D014157:Transcription Factors / Q000235:genetics*
D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors