Glioma-derived thrombospondin-1 modulates cd14+ cell tolerogenic properties.
Thrombospondin-1 (TSP1) plays a role in the immune tolerance, and is involved in the pathogenesis of glioma. This study aims to investigate the role of the glioma-derived TSP1 in the induction of the tumor immune tolerance. The results showed that the primary human glioma cells expressed high levels of TSP1. Glioma cells enhanced the expression of transforming growth factor (TGF)-β in CD4⁺ CD16⁻ naïve monocytes (Mos). The TGF-β⁺ Mos showed inhibitory effect on CD8⁺ T cell proliferation. We conclude that glioma cell-derived TSP1 facilitates the induction of TGF-β in Mos. The TSP1 may be a potential therapeutic target of glioma.
Graduate Management Team, Third Military Medical University , Chongqing , China 1.
Yuan
Y
Ma
Bo
B
Qu
Xun
X
Xia
Libin
L
Yang
Yongqin
Y
Kuang
Tao
T
Yang
Jingmin
J
Cheng
Haodong
H
Sun
Kexia
K
Fan
Jianwen
J
Gu
D000328:Adult; D005260:Female; D005910:Glioma / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D018950:Lipopolysaccharide Receptors / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D019700:Thrombospondin 1 / Q000032:analysis / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000032:analysis
D018950:Lipopolysaccharide Receptors; D019700:Thrombospondin 1; D016212:Transforming Growth Factor beta
Glioma; Immune tolerance; Monocytes; Thrombospondin-1; Transforming growth factor-β