Short circuiting the circadian system with a new generation of precision tools.
Circadian behavior in mammals is coordinated by neurons within the suprachiasmatic nucleus (SCN). In this issue, Lee et al. (2015) and Mieda et al. (2015) applied state-of-the-art genetic tools to dissect the microcircuits within the SCN generating circadian rhythmic behavior.
Laboratory of Circadian and Sleep Medicine, Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Dawn H
DH
Loh
Laboratory of Circadian and Sleep Medicine, Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Takashi
T
Kudo
Laboratory of Circadian and Sleep Medicine, Department of Psychiatry, Semel Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Electronic address: ccolwell@mednet.ucla.edu.
Christopher S
CS
Colwell
D056930:ARNTL Transcription Factors / Q000172:deficiency*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D057906:Circadian Clocks / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000096:biosynthesis*; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
D056930:ARNTL Transcription Factors; C538961:Bmal1 protein, mouse; D009479:Neuropeptides; C497950:neuromedin S; D001127:Arginine Vasopressin