FFAR out new targets for diabetes.
Dyslipidemia has long been associated with β cell dysfunction in the development of diabetes. Tang et al. (2015) have now revealed that β cell short-chain fatty acid receptors FFA2 and FFA3 are activated in an autocrine fashion and reduce insulin secretion in type 2 diabetes models.
Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Kacey J
KJ
Prentice
Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: michael.wheeler@utoronto.ca.
Michael B
MB
Wheeler
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D043562:Receptors, G-Protein-Coupled