Electrospun polyurethane-dextran nanofiber mats loaded with Estradiol for post-menopausal wound dressing.
Post-menopausal wound care management is a substantial burden on health services, since there are an increased number of elderly populations linked with age-related delayed wound healing. The controlled estrogen replacement can accelerate healing of acute cutaneous wounds, linked to its potent anti-inflammatory activity. The electrospinning technique can be used to introduce the desired therapeutic agents to the nanofiber matrix. So here we introduce a new material for wound tissue dressing, in which a polyurethane-dextran composite nanofibrous wound dressing material loaded with β-estradiol was obtained through electrospinning. Dextran can promote neovascularization and skin regeneration in chronic wounds. This study involves the characterization of these nanofibers and analysis of cell growth and proliferation to determine the efficiency of tissue regeneration on these biocomposite polymer nanofibrous scaffolds and to study the possibility of using it as a potential wound dressing material in the in vivo models.
Bionanosystem Engineering Department, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: afeesh@jbnu.ac.kr.
Afeesh Rajan
AR
Unnithan
Bionanosystem Engineering Department, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Arathyram Ramachandra Kurup
AR
Sasikala
Department of BIN Fusion Technology, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Priya
P
Murugesan
Department of BIN Fusion Technology, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Malarvizhi
M
Gurusamy
Department of BIN Fusion Technology, Chonbuk National University, Jeonju 561-756, Republic of Korea.
Dongmei
D
Wu
Division of Mechanical Design Engineering, College of Engineering, Jeonju 561-756, Republic of Korea. Electronic address: biochan@jbnu.ac.kr.
Chan Hee
CH
Park
Bionanosystem Engineering Department, Graduate School, Chonbuk National University, Jeonju 561-756, Republic of Korea; Division of Mechanical Design Engineering, College of Engineering, Jeonju 561-756, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
Cheol Sang
CS
Kim
D041721:3T3-L1 Cells; D000818:Animals; D001458:Bandages; D001777:Blood Coagulation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003911:Dextrans / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D065546:Drug Liberation; D004560:Electricity; D004958:Estradiol / Q000737:chemistry / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D017698:Postmenopause; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D003911:Dextrans; D004337:Drug Carriers; D011140:Polyurethanes; D004958:Estradiol
Dextran; Estradiol; Wound dressing