Comparison of 131I-MIBG, 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT scans in a patient with extra adrenal paraganglioma associated with SDH-B gene mutation.
Paragangliomas (PGLs) due to succinate dehydrogenase subunit B (SDH-B) mutation can be aggressive. A 40-year-old woman with normetanephrine-secreting, extra-adrenal, abdominal PGL due to SDH-B genetic mutation underwent surgical excision of primary, followed by whole-body I-MIBG scan after 6 months, which showed no abnormality. However, Ga-DOTANOC and F-FDG PET/CT scans showed primary site recurrence, hepatic and skeletal metastasis, with latter scan revealing more lesions. We suggest that F-FDG PET should be done in all patients with PGL due to SDH-B mutations, as it may show additional unsuspected lesions that may be missed by other tracers.
From the Department of Endocrinology, Seth G S Medical College, Parel, Mumbai, India; †Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, Annexe, Parel, Mumbai.
Rajeev
R
Kasaliwal
Gaurav
G
Malhotra
Anurag
A
Lila
Tushar
T
Bandgar
Nalini S
NS
Shah
D019797:3-Iodobenzylguanidine; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging; D009154:Mutation; D009942:Organometallic Compounds; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000235:genetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013385:Succinate Dehydrogenase / Q000235:genetics; D014057:Tomography, X-Ray Computed
C504894:68Ga-DOTANOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019797:3-Iodobenzylguanidine; C108095:SDHB protein, human; D013385:Succinate Dehydrogenase