Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries.
Dental caries is the most widespread disease and an economic burden. Nanotechnology is promising to inhibit caries by controlling biofilm acids and enhancing remineralization. Nanoparticles of silver were incorporated into composites/adhesives, along with quaternary ammonium methacrylates (QAMs), to combat biofilms. Nanoparticles of amorphous calcium phosphate (NACP) released calcium/phosphate ions, remineralized tooth-lesions and neutralized acids. By combining nanoparticles of silver/QAM/NACP, a new class of composites and adhesives with antibacterial and remineralization double benefits was developed. Various other nanoparticles including metal and oxide nanoparticles such as ZnO and TiO2, as well as polyethylenimine nanoparticles and their antibacterial capabilities in dental resins were also reviewed. These nanoparticles are promising for incorporation into dental composites/cements/sealants/bases/liners/adhesives. Therefore, nanotechnology has potential to significantly improve restorative and preventive dentistry.
Department of Endodontics, Prosthodontics and Operative Dentistry, Biomaterials & Tissue Engineering Division, University of Maryland Dental School, Baltimore, MD 21201, USA.
Lei
L
Cheng
Ke
K
Zhang
Michael D
MD
Weir
Mary Anne S
MA
Melo
Xuedong
X
Zhou
Hockin H K
HH
Xu
D000269:Adhesives / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D003731:Dental Caries / Q000188:drug therapy* / Q000517:prevention & control; D003764:Dental Materials / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D050997:Nanomedicine / Q000379:methods; D012834:Silver / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D000269:Adhesives; D000900:Anti-Bacterial Agents; D003764:Dental Materials; D012834:Silver
amorphous calcium phosphate nanoparticles; dental caries; oral biofilms; quaternary ammonium methacrylate; silver nanoparticles; tooth lesion remineralization