TNF-αG-308A polymorphism is associated with insulin resistance: a meta-analysis.
Tumor necrosis factor-α (TNF-α) promoter polymorphisms has been reported to be associated with obesity and insulin resistance and gained widespread attention. However, results obtained so far are quite conf‍‍licting. We therefore performed a meta-analysis to address this issue, basing on 17 studies from electronic databases (MEDLINE and EMBASE). No evidence of significant effect of TNF-αG-308A polymorphism on body mass index (BMI) or obesity risk was detected (BMI: WMDRE = 0.05, 95%CI: -0.62 to 0.73; risk of obesity: ORFE = 1.09, 95%CI: 0.87 to 1.35). G-308A variant was significantly associated with increased insulin levels in the overall (SMDFE = 0.12, 95%CI: 0.03 to 0.20) and obese subgroup analysis (SMDFE = 0.16, 95%CI: 0.03 to 0.29). In total, no significant result was observed for the association between TNF-α G-308A variant and HOMA-IR index. Nevertheless, subgroup analysis showed G-308A polymorphism was significantly associated with increased HOMA-IR in Caucasians (WMDFE = 0.49, 95%CI: 0.03 to 0.94). Our results indicate that TNF-αG-308A polymorphism has a significant effect on insulin resistance. However, it is unlikely that G-308A variant contributes to obesity.
Institute of Immunopharmacology and Immunotherapy, School of Pharmacy, Shandong University, Jinan, China.
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HG
Wang
Department of Pediatric, Qilu Hospital, Shandong University, Jinan, China.
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J
Yang
Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
H
H
Han
Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
F
F
Xu
Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
Y
Y
Bian
Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
H
H
Zhang
Department of Emergency, Qilu Hospital, Shandong University, Jinan, China wangjiali_2000@126.com.
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JL
Wang
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
D007328:Insulin; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha