Epithelioid angiomatous nodule of the nasal cavity: Report of 2 cases.
Epithelioid angiomatous nodule (EAN) is a novel clinicopathological entity characterized by a benign proliferation of endothelial cells with prominent epithelioid features. It can arise from any region of the body although it is increasingly being recognized in the head and neck. This paper presents two cases of EAN arising in the nasal cavity where the clinical presentations were recurrent unilateral epistaxis. In both cases, the lesions were excised endoscopically. Histopathologic analysis showed well-circumscribed proliferation of solid sheets of epithelioid endothelial cells and vascular channels in a background of mild chronic inflammatory infiltrate. Cytologic atypia was absent with rare mitotic figures seen. Immunohistochemical studies with CD31 and CD34 were strongly positive, thus confirming a vascular origin. Postoperative recovery was uneventful and no recurrence was seen in the follow-up period. EAN can be differentiated from other lesions demonstrating epithelioid vascular proliferation by means of clinical and histopathological characteristics. The present series seeks to inform that EAN should be regarded as a possible, albeit rare, cause of recurrent unilateral epistaxis. We advocate for endoscopic excision of EAN of the nasal cavity for diagnostic and therapeutic purposes.
Department of Otolaryngology, Head and Neck Surgery, Auckland City Hospital, 2 Park Road, Grafton, 1142 Auckland, New Zealand; Department of Otolaryngology, Head and Neck Surgery, North Shore Hospital, 124 Shakespeare Road, Westlake, 0622 Auckland, New Zealand. Electronic address: drwaikeatwong@hotmail.com.
Wai Keat
WK
Wong
Department of Surgery, Auckland City Hospital, 2 Park Road, Grafton, 1142 Auckland, New Zealand.
David H
DH
Lim
Department of Surgery, Auckland City Hospital, 2 Park Road, Grafton, 1142 Auckland, New Zealand.
Ching Wern
CW
Ong
D000293:Adolescent; D005260:Female; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology*; D009383:Neoplasms, Vascular Tissue / Q000000981:diagnostic imaging / Q000473:pathology*; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
Endoscopic sinus surgery; Epistaxis; Epithelioid; Nasal cavity; Vascular tumor