Synthesis and characterization of nanocrystalline forsterite coated poly(L-lactide-co-β-malic acid) scaffolds for bone tissue engineering applications.
In this research, after synthesizing poly(L-lactide-co-β-malic acid) (PLMA) copolymer, hybrid particles of ice and nanocrystalline forsterite (NF) as coating carriers were used to prepare NF-coated PLMA scaffolds. The porous NF-coated scaffolds were directly fabricated by a combined technique using porogen leaching and freeze-drying methods. The obtained results indicate that the scaffolds were structurally porous with NF particles on their surfaces. When compared to the uncoated scaffolds, the NF coating improved both mechanical properties as well as enhanced bioactivity of the scaffolds. In addition, in vitro biological response of the rat bone marrow stromal cells indicated that NF significantly increased the biocompatibility of NF-coated scaffolds compared with PLMA.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran. Electronic address: mozafari.masoud@gmail.com.
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Mozafari
Biotechnology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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Gholipourmalekabadi
Department of Chemistry, Bhupal Nobles Post Graduate College, Udaipur 313001, Rajasthan, India.
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Chauhan
Biomaterial Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, P.O. Box: 15875-4413, Tehran, Iran.
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Jalali
Computational Physiology and Biology Laboratory, Department of Computer Engineering and Computer Science, California State University, Long Beach, CA 90840, USA.
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Asgari
Tribology, Powder Metallurgy and Processing of Solid Recycled Research Group, Universidad del Valle, Cali, Colombia.
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Caicedoa
Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, USA.
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Hamlekhan
Division of Digestive and Liver Diseases, Department of Medicine, Irving Cancer Research Center, Columbia University New York, NY 10032, USA.
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Urbanska
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D001842:Bone and Bones / Q000502:physiology*; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008293:Malates / Q000138:chemical synthesis* / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D017207:Rats, Sprague-Dawley; D017655:Silicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D017154:Stromal Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
D020099:Coated Materials, Biocompatible; D008293:Malates; D011091:Polyesters; D017655:Silicon Compounds; C503823:forsterite; C494686:poly(L-lactide-co-beta-malic acid)
Biocompatibility; Coating; Scaffold; Tissue engineering