Somatic mutations of cell-free circulating DNA detected by next-generation sequencing reflect the genetic changes in both germinal center B-cell-like and activated B-cell-like diffuse large B-cell lymphomas at the time of diagnosis.
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Elodie
E
Bohers
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Pierre Julien
PJ
Viailly
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Sydney
S
Dubois
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Philippe
P
Bertrand
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Catherine
C
Maingonnat
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Sylvain
S
Mareschal
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Philippe
P
Ruminy
Department of Pathology, Centre Henri Becquerel, Rouen, France.
Jean-Michel
JM
Picquenot
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France.
Christian
C
Bastard
UMR INSERM U917, CHU Pontchaillou, Rennes, France.
Fabienne
F
Desmots
UMR INSERM U917, CHU Pontchaillou, Rennes, France.
Thierry
T
Fest
INSERM U955, Henri Mondor Hospital, Creteil, France.
Karen
K
Leroy
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France.
Hervé
H
Tilly
INSERM U918, Centre Henri Becquerel, Université de Rouen, IRIB, France Department of Clinical Hematology, Centre Henri Becquerel, Rouen, France fabrice.jardin@chb.unicancer.fr.
Fabrice
F
Jardin
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018858:Germinal Center / Q000378:metabolism / Q000473:pathology; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008213:Lymphocyte Activation; D008223:Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins
NGS; diffuse large B-cell lymphoma; liquid biopsy; mutations