Lipid Signaling in Tumorigenesis.
Lipids are important cellular building blocks and components of signaling cascades. Deregulation of lipid metabolism or signaling is frequently linked to a variety of human diseases such as diabetes, cardiovascular diseases, and cancer. It is widely believed that lipid molecules or their metabolic products are involved in tumorigenic inflammation and thus, lipids are implicated as significant contributors or even primary triggers of tumorigenesis. Lipids are believed to directly or indirectly activate growth promoting signals such as those involving LPA, insulin, IGF-1 and EGF to promote cancer cell growth. Cellular levels of certain lipids, including sphingosine-1-phosphate and ceramide, maintain a delicate balance between cell death and survival and alterations in their levels lead to unfavorable consequences including tumorigenesis. This article provides an overview of current knowledge that implicates lipids in tumorigenesis and explores the potential mechanisms that support a positive link between obesity and cancer.
Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York.
Renyan
R
Liu
Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York.
Ying
Y
Huang
Cancer; Ceramide; Lipid metabolism; Monoglyceride lipase; Obesity; Sphingosine-1-phosphate