Metabolic switches linked to pluripotency and embryonic stem cell differentiation.
Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.
Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
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Shyh-Chang
Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address: george.daley@childrens.harvard.edu.
George Q
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Daley
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D053595:Embryonic Stem Cells / Q000378:metabolism* / Q000502:physiology*; D006019:Glycolysis / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans
D006657:Histones; D000105:Acetyl Coenzyme A