[Calcium channel blockers pharmacology and their use as tocolytics].
Nifedipine and nicardipine are both calcium channel inhibitors, used off-label as tocolytics in preterm labour. Their use is related to their relaxing effects on uterin muscle by L-type voltage dependent calcium channels blockade. This article describes pharmacological effects, pharmacokinetics properties and tolerance of these drugs. It also discusses serious adverse effects, such as pulmonary edema, reported with both nifedipine and nicardipine in preterm labour.
Service de pharmacologie clinique, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France; Université François-Rabelais, 37032 Tours, France. Electronic address: theodora.angoulvant@univ-tours.fr.
T
T
Bejan-Angoulvant
Service de pharmacologie clinique, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.
J
J
Crochet
Service de pharmacologie clinique, hôpital Bretonneau, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France.
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AP
Jonville-Bera
D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D006801:Humans; D009529:Nicardipine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D015149:Tocolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology
D002121:Calcium Channel Blockers; D015149:Tocolytic Agents; D009529:Nicardipine; D009543:Nifedipine
Adverse reactions; Calcium channel blockers; Effets indésirables; Inhibiteurs des canaux calciques; Nicardipine; Nifédipine; Pharmacocinétique; Pharmacokinetics; Pulmonary edema; Tocolyse; Tocolysis; Œdème pulmonaire