Cuprizone does not induce CNS demyelination in nonhuman primates.
Cognitive decline is a common symptom in multiple sclerosis patients, with profound effects on the quality of life. A nonhuman primate model of multiple sclerosis would be best suited to test the effects of demyelination on complex cognitive functions such as learning and reasoning. Cuprizone has been shown to reliably induce brain demyelination in mice. To establish a nonhuman primate model of multiple sclerosis, young adult cynomolgus monkeys were administered cuprizone per os as a dietary supplement. The subjects received increasing cuprizone doses (0.3-3% of diet) for up to 18 weeks. Magnetic resonance imaging and immunohistological analyses did not reveal demyelination in these monkeys.
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Zhihong
Z
Chen
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Jacqueline T
JT
Chen
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Matthew
M
Johnson
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Zachary C
ZC
Gossman
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Megan
M
Hendrickson
Neurological Institute, Cleveland Clinic Cleveland, Ohio.
Ken
K
Sakaie
Department of Neurosurgery, Massachusetts General Hospital Boston, Massachusetts.
Clarissa
C
Martinez-Rubio
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio ; Center for Neurological Restoration, Neurological Institute, Cleveland Clinic Cleveland, Ohio.
John T
JT
Gale
Department of Neurosciences, Cleveland Clinic Cleveland, Ohio.
Bruce D
BD
Trapp