Glucose- and pH-responsive nanogated ensemble based on polymeric network capped mesoporous silica.
In this paper, a glucose and pH-responsive release system based on polymeric network capped mesoporous silica nanoparticles (MSN) has been presented. The poly(acrylic acid) (PAA) brush on MSN was obtained through the surface-initiated atom transfer radical polymerization (SI-ATRP) of t-butyl acrylate and the subsequent hydrolysis of the ester bond. Then the PAA was glycosylated with glucosamine to obtain P(AA-AGA). To block the pore of silica, the P(AA-AGA) chains were cross-linked through the formation of boronate esters between 4,4-(ethylenedicarbamoyl)phenylboronic acid (EPBA) and the hydroxyl groups of P(AA-AGA). The boronate esters disassociated in the presence of glucose or in acidic conditions, which lead to opening of the mesoporous channels and the release of loaded guest molecules. The rate of release could be tuned by varying the pH or the concentration of glucose in the environment. The combination of two stimuli exhibited an obvious enhanced release capacity in mild acidic conditions (pH 6.0).
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Lei
L
Tan
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Mei-Yan
MY
Yang
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.|‡College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang 471022, People's Republic of China.
Hai-Xia
HX
Wu
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Zhao-Wen
ZW
Tang
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Jian-Yun
JY
Xiao
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Chuan-Jun
CJ
Liu
†Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, People's Republic of China.
Ren-Xi
RX
Zhuo
D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004058:Diffusion; D005947:Glucose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
D003692:Delayed-Action Preparations; D053769:Nanocapsules; D011108:Polymers; D012822:Silicon Dioxide; D005947:Glucose
controlled drug release; core−shell nanoparticles; glucose response; glycosylated polymer; mesoporous silica nanoparticles; pH response