Global scientific vision with local vigilance: renal transplantation in developing countries.
BACKGROUND
Renal Transplantation is the most effective treatment for patients with end-stage renal disease, which is fortunately available in the developing countries, even for poor people. Nonetheless, the way forward should be the implementation of advanced science of transplantation, allograft monitoring abilities, knowledge about the epidemiology of renal disease in any specific region, awareness about the influence of ethenic and genetic factors immunosuppressant bioavailability, and post-transplant complications all strongly affecting the patients and allograft survival.


METHODS
In this process we searched mainly in PubMed, Web of Science and Google Scholar data bases for key words of renal allograft monitoring, post-transplant infections, renal/kidney transplantation and Iran. We followed the cross articles to follow our main idea to find a connection between modern advancement in renal allograft monitoring and our practice in developing countries. Another focus was on the special infectious and non-infection complication that do exist in specific region and need specific considerations.


RESULTS
Implementation of modern techniques of immune monitoring, allograft function, awareness about the specific infectious and non-infectious disease in each region improves the quality of renal transplantation.


CONCLUSIONS
We need to combine the advance scientific vision with local vigilance to achieve the best outcome in renal allograft recipients.
Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran.
Mohammad Reza
MR
Ardalan
Antibodies; MicroRNAs; Tissue Donors; Transplantation