Low level of the X-linked ribosomal protein S4 in human urothelial carcinomas is associated with a poor prognosis.
OBJECTIVE
We determined whether the Y-box binding protein-1 (YB-1) and its binding partner, the X-linked ribosomal protein S4 (RPS4X), are associated with clinical outcome in bladder cancer.


METHODS
A population of 167 patients with muscle-invasive bladder tumor without evidence of metastasis at time of cystectomy was analyzed retrospectively. YB-1 and RPS4X expressions were evaluated immunohistochemically in tumors and analyzed for association with clinical variables and survival.


RESULTS
Kaplan-Meier and multivariate Cox regression analyses indicated that low expression of RPS4X was associated with a higher risk of death or disease recurrence. In contrast, YB-1 was not significantly associated with either recurrence-free or overall survival.


CONCLUSIONS
Low RPS4X expression is associated with poor disease-specific and recurrence-free survival in bladder cancer.
Centre de Recherche sur le Cancer de l'Université Laval, 9 McMahon Street, Québec City, Québec, Canada.
Éric R
ÉR
Paquet
Hélène
H
Hovington
Hervé
H
Brisson
Cédric
C
Lacombe
Hélène
H
Larue
Bernard
B
Têtu
Louis
L
Lacombe
Yves
Y
Fradet
Michel
M
Lebel
D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D012269:Ribosomal Proteins / Q000378:metabolism*; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D019459:Urothelium; D051840:Y-Box-Binding Protein 1 / Q000378:metabolism
D012269:Ribosomal Proteins; D051840:Y-Box-Binding Protein 1; C031798:ribosomal protein S4
RPS4X; YB-1; bladder cancer; disease outcome; immunohistochemistry; prognostic biomarker