Silk fibroin-based nanoparticles for drug delivery.
Silk fibroin (SF) is a protein-based biomacromolecule with excellent biocompatibility, biodegradability and low immunogenicity. The development of SF-based nanoparticles for drug delivery have received considerable attention due to high binding capacity for various drugs, controlled drug release properties and mild preparation conditions. By adjusting the particle size, the chemical structure and properties, the modified or recombinant SF-based nanoparticles can be designed to improve the therapeutic efficiency of drugs encapsulated into these nanoparticles. Therefore, they can be used to deliver small molecule drugs (e.g., anti-cancer drugs), protein and growth factor drugs, gene drugs, etc. This paper reviews recent progress on SF-based nanoparticles, including chemical structure, properties, and preparation methods. In addition, the applications of SF-based nanoparticles as carriers for therapeutic drugs are also reviewed.
State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China. maobin.xie@connect.polyu.hk.|Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hong Kong 999077, China. maobin.xie@connect.polyu.hk.|Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China. maobin.xie@connect.polyu.hk.
Zheng
Z
Zhao
Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hong Kong 999077, China. tcliyi@polyu.edu.hk.
Yi
Y
Li
Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hong Kong 999077, China. maobin.xie@connect.polyu.hk.
Mao-Bin
MB
Xie
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D005349:Fibroins / Q000737:chemistry* / Q000302:isolation & purification; D018014:Gene Transfer Techniques; D006801:Humans; D055767:Immobilized Proteins / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D047011:Silk / Q000737:chemistry
D000970:Antineoplastic Agents; D004337:Drug Carriers; D055767:Immobilized Proteins; D047011:Silk; D005349:Fibroins