Descending projections from the nucleus accumbens shell excite activity of taste-responsive neurons in the nucleus of the solitary tract in the hamster.
The nucleus of the solitary tract (NST) and the parabrachial nuclei (PbN) are the first and second relays in the rodent central taste pathway. A series of electrophysiological experiments revealed that spontaneous and taste-evoked activities of brain stem gustatory neurons are altered by descending input from multiple forebrain nuclei in the central taste pathway. The nucleus accumbens shell (NAcSh) is a key neural substrate of reward circuitry, but it has not been verified as a classical gustatory nucleus. A recent in vivo electrophysiological study demonstrated that the NAcSh modulates the spontaneous and gustatory activities of hamster pontine taste neurons. In the present study, we investigated whether activation of the NAcSh modulates gustatory responses of the NST neurons. Extracellular single-unit activity was recorded from medullary neurons in urethane-anesthetized hamsters. After taste response was confirmed by delivery of sucrose, NaCl, citric acid, and quinine hydrochloride to the anterior tongue, the NAcSh was stimulated bilaterally with concentric bipolar stimulating electrodes. Stimulation of the ipsilateral and contralateral NAcSh induced firings from 54 and 37 of 90 medullary taste neurons, respectively. Thirty cells were affected bilaterally. No inhibitory responses or antidromic invasion was observed after NAcSh activation. In the subset of taste cells tested, high-frequency electrical stimulation of the NAcSh during taste delivery enhanced taste-evoked neuronal firing. These results demonstrate that two-thirds of the medullary gustatory neurons are under excitatory descending influence from the NAcSh, which is a strong indication of communication between the gustatory pathway and the mesolimbic reward pathway.
Department of Anatomy, School of Medicine, Southern Illinois University, Carbondale, Illinois; Jiamusi Stomatological Hospital, School of Stomatology, Jiamusi University, Heilongjiang, People's Republic of China;
Cheng-Shu
CS
Li
Laboratory of Oral Cell Biology, Department of Emergency, Beijing Stomatological Hospital, Capital Medical University School of Stomatology, Beijing, People's Republic of China; and.
Da-Peng
DP
Lu
Department of Physiology and Neuroscience, College of Dentistry, and Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung, Gangwon, Korea ykcho@gwnu.ac.kr.
Young K
YK
Cho
D000200:Action Potentials / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D006224:Cricetinae; D004558:Electric Stimulation; D007839:Functional Laterality; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009714:Nucleus Accumbens / Q000166:cytology*; D018408:Patch-Clamp Techniques; D066250:Pretectal Region / Q000166:cytology*; D013649:Taste / Q000502:physiology*
gustatory neuron; in vivo electrophysiology; medullary neuron; modulation; reward