A meta-analysis of resected metachronous second non-small cell lung cancer.
This meta-analysis was designed to determine the effect of surgical treatment on overall survival of patients treated surgically for a second non-small cell lung cancer (NSCLC) that occurred after resection of an initial NSCLC. PubMed and Scopus databases were queried. Nine studies were identified. Meta-analyses revealed pooled operative mortality of 7% for the second resection, pooled 5-year overall survival of 46% after resection of the second NSCLC, and 79% after resection of the first NSCLC. These results suggest that surgical resection can be considered for patients who have a second primary NSCLC after resection of an initial lung cancer.
Department of Thoracic Surgery, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto, Japan. Electronic address: mhamaji@kuhp.kyoto-u.ac.jp.
Masatsugu
M
Hamaji
Division of Cardiothoracic Surgery, Altru Hospital, Grand Forks, North Dakota.
Syed Osman
SO
Ali
Division of Thoracic Surgery, Department of Surgery, Baylor College of Medicine, Houston, Texas.
Bryan M
BM
Burt
D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D011013:Pneumonectomy / Q000379:methods; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome