Seminal Levels of Pro-inflammatory (CXCL1, CXCL9, CXCL10) and Homeostatic (CXCL12) Chemokines in Men With Asymptomatic Chlamydia trachomatis Infection.
BACKGROUND
Chemokines play important roles in immune system activation against microbial infections.


OBJECTIVE
The current study aimed to evaluate seminal levels of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in Chlamydia trachomatis infected patients.


METHODS
The C. trachomatis infection was determined employing Polymerase Chain Reaction (PCR)-based methods. Seminal concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured by Enzyme-Linked Immunosorbent Assay (ELISA).


RESULTS
The current study results demonstrated that the semen levels of CXCL1 and CXCL9, but not CXCL10 and CXCL12, significantly increased in C. trachomatis infected patients compared to the healthy controls.


CONCLUSIONS
Based on the current study results, it may be concluded that both CXCL1 and CXCL9 play more important roles than CXCL10 and CXCL12 in induction of immune responses against C. trachomatis and could possibly be considered as future targets for immunotherapy of C. trachomatis infection.
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Hamid
H
Hakimi
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Nahid
N
Zainodini
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Hossein
H
Khorramdelazad
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Mohammad
M
Kazemi Arababadi
Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
Gholamhossein
G
Hassanshahi
Chemokine, CXCL1, CXCL9, CXCL10 and CXCL12; Chlamydia trachomatis