[Ectopic Adrenocorticotropic Hormone-producing Pulmonary Carcinoid Tumor Presenting as Cushing Syndrome].
The patient was a 57-year-old female who felt muscle weakness and visited a physician. Hypokalemia was pointed out, and she was referred to our hospital for detailed examination and treatment. Hormone-related tests and imaging were performed, and the patient was diagnosed as Cushing syndrome. Moreover, an ectopic adrenocorticotropic hormone (ACTH)-producing tumor was suspected. The whole body was examined to find a tumor, but no apparent lesion was found, except for a small nodule of 5-mm in size was present in the right middle pulmonary lobe on chest computed tomography (CT). It was decided to perform surgical resection for both diagnosis and treatment. Pathological diagnosis was a typical carcinoid. On immunostaining, ACTH-positive cells were detected, and the lesion was definitely diagnosed as an ectopic ACTH-producing tumor. Since the ACTH level after surgery returned to normal, the lesion was concluded to be completely excised.
Department of Thoracic Surgery, Ehime Prefectural Central Hospital, Matsuyama, Japan.
Daisuke
D
Taniguchi
Takahiro
T
Sawada
Osamu
O
Ebisui
Katsumi
K
Kito
Takeshi
T
Nagayasu
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis*; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D003480:Cushing Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D008875:Middle Aged; D011013:Pneumonectomy; D014057:Tomography, X-Ray Computed
D000324:Adrenocorticotropic Hormone