Macular thickness assessed with spectral domain OCT in a population-based study of children: normative data, repeatability and reproducibility and comparison with time domain OCT.
OBJECTIVE
To collect data on macular thickness assessed with Cirrus OCT in healthy children in a population-based study, to examine the repeatability and reproducibility, and to compare the values with Stratus OCT.


METHODS
Fifty-eight 6- to 15-year-old children, born at term, were examined. Best-corrected visual acuity and refraction were assessed. One examiner performed three OCT assessments, and the repeatability was calculated. Thereafter, a second examiner repeated the examinations to calculate the reproducibility. One eye was randomized to be included in the normal material. Finally, the second examiner assessed the macular thickness with the Stratus OCT.


RESULTS
The mean value (±SD) of central macular thickness was 255 ± 17 μm, and the total macular volume was 10.3 ± 0.5 mm(3) . No correlations were found between macular thickness and age, gender or refraction. The coefficients of variance (CoVs) for both repeatability and reproducibility were <1.21%, and the intraclass correlations (ICCs) were over 0.86. The Cirrus OCT showed a 29% thicker central macular thickness than the Stratus OCT.


CONCLUSIONS
Normal values for macular thickness assessed with Cirrus OCT in healthy full-term children in a population-based study were reported. The assessments showed high repeatability and reproducibility. The values of Cirrus and Stratus OCT differed and the techniques were not interchangeable.
Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
Anna
A
Molnar
Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
Gerd
G
Holmström
Department of Neuroscience/Ophthalmology, Uppsala University, Uppsala, Sweden.
Eva
E
Larsson
D000293:Adolescent; D000465:Algorithms; D001724:Birth Weight; D002648:Child; D005260:Female; D005865:Gestational Age; D006801:Humans; D008266:Macula Lutea / Q000033:anatomy & histology*; D008297:Male; D015588:Observer Variation; D009929:Organ Size; D012016:Reference Values; D012029:Refraction, Ocular / Q000502:physiology; D015203:Reproducibility of Results; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology
children; normal values; optical coherence tomography; repeatability; reproducibility