The biology of IQGAP proteins: beyond the cytoskeleton.
IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and intercellular interactions. Fungal and mammalian IQGAPs are implicated in cytokinesis. IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung. The functions of IQGAPs can be corrupted during oncogenesis and are usurped by microbial pathogens. Therefore, IQGAPs represent intriguing candidates for novel therapeutic agents. While modulation of the cytoskeletal architecture was initially thought to be the primary function of IQGAPs, it is now clear that they have roles beyond the cytoskeleton. This review describes contributions of IQGAPs to physiology at the organism level.
Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA.
Andrew C
AC
Hedman
Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA.
Jessica M
JM
Smith
Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA sacksdb@mail.nih.gov.
David B
DB
Sacks
D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000378:metabolism; D001921:Brain / Q000166:cytology / Q000378:metabolism; D003141:Communicable Diseases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D048749:Cytokinesis / Q000235:genetics; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008168:Lung / Q000166:cytology / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*
D020690:GTPase-Activating Proteins; C101203:IQ motif containing GTPase activating protein 1; C101002:IQGAP2 protein, human; C000594387:IQGAP3 protein, human; D020703:ras GTPase-Activating Proteins
IQGAP1; IQGAP2; IQGAP3; biology; therapeutics