Solving a cold case of haemolysis: back to the basics.
Membrane disorders comprise an important group of inherited haemolytic anaemias. Diagnostic work-up starts with examination of the blood smear, followed by osmotic gradient ektacytometry. In special cases DNA analysis is performed to confirm the diagnosis. For this purpose a next-generation sequencing-based method has been developed. The combination of these techniques established the correct diagnosis in a case of haemolytic anaemia of unknown cause.
Department of Internal Medicine, Deventer Hospital, Deventer, the Netherlands.
R
R
Bijleveld
J
J
de Kok
B
B
van der Zwaag
R
R
van Wijk
T
T
Diekman
D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006801:Humans; D017422:Sequence Analysis, DNA / Q000379:methods*; D055815:Young Adult