Disseminated emm Type 12 Group A Streptococcus and Review of Invasive Disease.
The authors present a case of invasive group A Streptococcus (GAS) in a previously healthy 63-year-old male complicated by trans-esophageal echocardiogram negative endocarditis, septic arthritis, and multiple cerebral septic emboli. Despite antibiotics and drainage of his largest brain abscess, the patient expired. This case highlights the potential mortality from invasive GAS disease. Included is a review of current literature regarding invasive GAS that addresses its presentation, prevalence, virulence and treatment.
Department of Medicine (ALH, JMP), Emory University School of Medicine, Atlanta, Georgia; Division of Infectious Diseases (HMB, DSW, EKS, SWS, JLS), Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; and Atlanta Veterans Administration Medical Center (SWS), Decatur, Georgia.
Arielle L
AL
Heeke
Henry M
HM
Blumberg
Jason M
JM
Perry
David S
DS
Weiss
Emily K
EK
Crispell
Sarah W
SW
Satola
Jorge L
JL
Salinas
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000209:etiology; D001922:Brain Abscess / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D004322:Drainage / Q000379:methods; D004452:Echocardiography / Q000379:methods; D004696:Endocarditis / Q000000981:diagnostic imaging / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D010400:Penicillin G / Q000008:administration & dosage*; D013290:Streptococcal Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D013297:Streptococcus pyogenes / Q000302:isolation & purification / Q000472:pathogenicity; D013582:Synovial Fluid / Q000382:microbiology; D014057:Tomography, X-Ray Computed / Q000379:methods
D000900:Anti-Bacterial Agents; D010400:Penicillin G