Clinical effect of postconditioning in ST-elevation myocardial infarction patients treated with primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials.
OBJECTIVE
To evaluate the clinical effect of postconditioning on patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).


METHODS
Randomized controlled trials were identified by searching relevant databases published up to April 2nd, 2014. A meta-analysis of eligible studies was performed by Stata 12.0 and Review Manager 5.2 with a fixed-effect model.


RESULTS
Ten studies providing adverse cardiac events in a total of 1346 STEMI patients treated with primary PCI were identified. The occurrence of heart failure was significantly reduced in patients treated with postconditioning compared with usual care (risk ratio (RR) 0.533; 95% confidence intervals (CI) 0.368-0.770), whereas non-fatal reinfarction slightly increased in the postconditioning group (RR 2.746; 95% CI 1.007-7.488). No significant difference in total major adverse cardiac events (MACEs) was observed between the two groups (RR 0.876; 95% CI 0.671-1.144).


CONCLUSIONS
Postconditioning in STEMI patients undergoing primary PCI significantly reduces the risk of heart failure, but fails to decrease the incidence of total MACEs and the risk of non-fatal reinfarction.
Department of Cardiovascular Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China; Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, China.
Xian-qing
XQ
Hu
Jian
J
Cheng
Biao
B
Tang
Zhong-heng
ZH
Zhang
Ke
K
Huang
Yi-ping
YP
Yang
Yan-yan
YY
Mao
Ming
M
Zhong
Shen-wen
SW
Fu
D003326:Coronary Circulation; D005260:Female; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D057775:Ischemic Postconditioning; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy*; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
Coronary intervention; Myocardial infarction; Postconditioning