Invasive recordings in the human auditory cortex.
This chapter provides an overview of current invasive recording methodology and experimental paradigms used in the studies of human auditory cortex. Invasive recordings can be obtained from neurosurgical patients undergoing clinical electrophysiologic evaluation for medically refractory epilepsy or brain tumors. This provides a unique research opportunity to study the human auditory cortex with high resolution both in time (milliseconds) and space (millimeters) and to generate valuable information about its organization and function. A historic overview presents the development of the experimental approaches from the pioneering works of Wilder Penfield to modern day. Practical issues regarding research subject population, stimulus presentation, data collection, and analysis are discussed for acute (intraoperative) and chronic experiments. Illustrative examples are provided from experimental paradigms, including studies of spectrotemporal processing, functional connectivity, and functional lesioning in human auditory cortex.
Department of Neurosurgery, University of Iowa, Iowa City, IA, USA. Electronic address: kirill-nourski@uiowa.edu.
Kirill V
KV
Nourski
Department of Neurosurgery, University of Iowa, Iowa City, IA, USA.
Matthew A
MA
Howard
D000161:Acoustic Stimulation; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception; D001931:Brain Mapping; D004594:Electrophysiology; D006801:Humans
averaged evoked potential; brain mapping; electrocorticography; epilepsy; functional connectivity; high gamma activity; intracranial electrophysiology