Microneedle biosensor for real-time electrical detection of nitric oxide for in situ cancer diagnosis during endomicroscopy.
A dual-diagnostic system of endom-icroscope and microneedle sensor is developed to demonstrate high-resolution imaging combined with electrical real-time detection of NO released from cancer tissues. The dual-diagnostic system can be a new platform for facile, precise, rapid, and accurate detection of cancers in various biomedical applications.
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Do Hee
DH
Keum
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Ho Sang
HS
Jung
Department of Integrative Biosciences and Biotechnology, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Taejun
T
Wang
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Myeong Hwan
MH
Shin
Department of Integrative Biosciences and Biotechnology, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Young-Eun
YE
Kim
Department of Integrative Biosciences and Biotechnology, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Ki Hean
KH
Kim
Department of Integrative Biosciences and Biotechnology, POSTECH, 77 Cheongam-ro, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
G-One
GO
Ahn
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, 790-784, Korea.
Sei Kwang
SK
Hahn
D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D003952:Diagnostic Imaging; D004195:Disease Models, Animal; D007091:Image Processing, Computer-Assisted; D008545:Melanoma / Q000175:diagnosis*; D051379:Mice; D009339:Needles; D009569:Nitric Oxide / Q000032:analysis*; D000067996:RAW 264.7 Cells
D009569:Nitric Oxide
PEDOT; biosensors; cancer diagnosis; microneedles; nitric oxide