Sickle cell in Latin America and the United States [corrected].
Latin Americans are an underappreciated population affected by sickle cell disease (SCD). Sickle trait and SCD exist throughout Latin America and U.S. Latino communities. We describe the epidemiology and genetic heterogeneity of SCD among Latin Americans, and fetal hemoglobin expression. National population-based newborn screening for SCD is limited to Brazil, Costa Rica, and the U.S. Available and extrapolated data suggest that over 6,000 annual births and 100,000-150,000 Latin Americans are affected by SCD. This comprehensive review highlights the substantial numbers and population distribution of SCD and sickle trait in Latin America, and where national newborn screening programs for SCD exist.
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, New York.
Alexandra
A
Huttle
Department of Psychiatry and Neurosciences, Cardiovascular Institute, Institute for Biological Research, University of Zulia, Maracaibo Venezuela, and G.H. Sergievsky Center, Columbia University Medical Center, New York, New York.
Gladys E
GE
Maestre
Department of Medicine, Columbia University Medical Center, New York, New York.
Rafael
R
Lantigua
Division of Pediatric Hematology, Oncology, Stem Cell Transplantation, Department of Pediatrics, Columbia University Medical Center, New York, New York.
Nancy S
NS
Green
D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000503:physiopathology; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D012805:Sickle Cell Trait; D014481:United States / Q000453:epidemiology
Latin America; hemoglobinopathies; sickle cell; sickle trait