Acute vision loss after ocriplasmin use.
OBJECTIVE
There have been reports in the literature of transient vision loss after ocriplasmin injection and ellipsoid layer disruption on spectral domain optical coherence tomography. The authors report a patient with transient vision loss and more prolonged ellipsoid layer dysfunction.


METHODS
The authors present a 55-year-old woman with vitreomacular traction and a small foveal schisis who received ocriplasmin injection and experienced sudden transient vision loss. Spectral domain optical coherence tomography imaging revealed significantly increased schisis, new subretinal cavity, and prolonged ellipsoid layer disruption at 9 months.


CONCLUSIONS
Previous reports suggested that acute vision loss after ocriplasmin injection may be due to ellipsoid layer disruption. This case showed vision loss, which may due to increased foveal schisis and a new subretinal cavity on spectral domain optical coherence tomography imaging. There was little correlation between ellipsoid layer loss and visual function.
Department of Ophthalmology, The George Washington University, Washington, D.C.
Benjamin
B
Reiss
Lindsay
L
Smithen
Sam
S
Mansour
D001766:Blindness / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D004596:Electroretinography; D005260:Female; D005341:Fibrinolysin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D058449:Intravitreal Injections; D008875:Middle Aged; D010446:Peptide Fragments / Q000008:administration & dosage / Q000009:adverse effects*; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin