Vessel network formation in response to intermittent hypoxia is frequency dependent.
A combined experimental and mathematical model of intermittent hypoxia (IH) conditioned engineered tissue was used to characterize the effects of IH on the formation of in vitro vascular networks. Results showed that the frequency of hypoxic oscillations has pronounced influence on the vascular response of endothelial cells and fibroblasts.
Chemical Engineering and Materials Science, University of California, 916 Engineering Tower, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2400 Engineering Hall, Irvine, CA 92697, USA.
Seema M
SM
Ehsan
Chemical Engineering and Materials Science, University of California, 916 Engineering Tower, Irvine, CA 92697, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, 2400 Engineering Hall, Irvine, CA 92697, USA; Biomedical Engineering, University of California, 3120 Natural Sciences II, Irvine, CA 92697, USA; Department of Medicine, University of California, 333 City Blvd. West, Suite 400, Orange, CA 92868, USA. Electronic address: scg@wustl.edu.
Steven C
SC
George
D001808:Blood Vessels / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005312:Fetal Blood / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D010100:Oxygen
3D culture; Endothelial cells; Intermittent hypoxia; Oxygen; Vascular endothelial growth factor; Vasculogenesis