Hemoglobin Degrading Proteases of Plasmodium falciparum as Antimalarial Drug Targets.
Plasmepsins, falcipains and aminopeptidases are Plasmodium falciparum proteases involved in human host hemoglobin degradation and other processes like erythrocyte invasion and rupture. Antimalarial drug resistance and natural selection in parasite are important reasons that create the urgent need of novel targets and lead compounds to overcome the burden of malaria. This report explored progress of the study covering proteases and their inhibitors specific to hemoglobin degradation. Additionally, in silico predicted antimalarial targets, balancing selection and drug-protein interaction are included.
Department of Biotechnology, RBS, Engineering Technical campus, Agra, India-283105. tabish.iet@gmail.com.
Tabish
T
Qidwai
D000626:Aminopeptidases / Q000037:antagonists & inhibitors; D000962:Antimalarials / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D001665:Binding Sites; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance / Q000235:genetics; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology / Q000473:pathology; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000188:drug therapy* / Q000235:genetics / Q000469:parasitology; D062105:Molecular Docking Simulation; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011485:Protein Binding
D000962:Antimalarials; D015853:Cysteine Proteinase Inhibitors; D006454:Hemoglobins; D000626:Aminopeptidases; D003546:Cysteine Endopeptidases; D016282:Aspartic Acid Endopeptidases; C089643:plasmepsin