Guillain-Barré syndrome variant with facial diplegia and paresthesias associated with IgM anti-GalNAc-GD1a antibodies.
We herein report the case of a 19-year-old woman with facial diplegia and paresthesias (FDP) preceded by flu-like symptoms. We diagnosed the patient with a regional variant of Guillain-Barré syndrome due to decreased tendon reflexes, albuminocytological dissociation in the cerebrospinal fluid and demyelinating features on nerve conduction studies. The patient also had IgM anti-GalNAc-GD1a antibodies, and treatment with glucocorticoids was effective for treating the facial diplegia, but not paresthesia. Therefore, facial palsy may have a different pathophysiology from paresthesia or other symptoms of FDP, which responds to glucocorticoid therapy.
Department of Neurology, Yokohama Municipal Citizen's Hospital, Japan.
Ryuichiro
R
Hayashi
Shigeki
S
Yamaguchi
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage; D001323:Autoantibodies / Q000097:blood*; D005158:Facial Paralysis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D005938:Glucocorticoids / Q000008:administration & dosage; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008775:Methylprednisolone / Q000008:administration & dosage; D010292:Paresthesia / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D020127:Recovery of Function; D016896:Treatment Outcome; D000077483:Valacyclovir; D014633:Valine / Q000008:administration & dosage / Q000031:analogs & derivatives
D000998:Antiviral Agents; D001323:Autoantibodies; D005732:Gangliosides; D005938:Glucocorticoids; D007075:Immunoglobulin M; C055253:IV(4)-galactosyl-N-acetylganglioside GD1a; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir; D008775:Methylprednisolone