[Development of injection containers for patient and medical staff].
Recently, there has been a transition from glass to plastic injection containers in Japan. In our previous study, we suggested that plastic containers had less impurity contamination than glass containers. However, the use of some plasticizers has been limited because of their endocrine disrupting effects. Therefore, contamination has been a concern due to chemicals in injection solution packed with plastic containers. Indeed, in our recent study, photoinitiators were detected in an injection solution coming from plastic containers. Photoinitiators mainly exist in ink. We therefore speculated that ink originating from a photoinitiator directly printing on plastic containers had migrated into the injection solutions. In a clinical setting, plastic containers are very tractable because they are lightweight and less breakable. On the other hand, from a safety view point, these containers may be hazardous because of permeation by steam, ambient air or photoinitiators. In the present symposium, we will discuss the risk of photoinitiators leaking into injection solution packed with plastic containers, and countermeasures to avoid this risk.
Department of Pharmacy, Okayama University Hospital.
Yoichi
Y
Kawasaki
Toshiaki
T
Sendo
D002470:Cell Survival / Q000187:drug effects; D004340:Drug Contamination; D004349:Drug Packaging / Q000295:instrumentation; D052244:Endocrine Disruptors / Q000032:analysis; D006801:Humans; D019999:Pharmaceutical Solutions / Q000032:analysis; D055668:Photochemical Processes; D010969:Plastics
D052244:Endocrine Disruptors; D019999:Pharmaceutical Solutions; D010969:Plastics