Heterocyclic Scaffolds: Centrality in Anticancer Drug Development.
Cancer has been cursed for human beings for long time. Millions people lost their lives due to cancer. Despite of the several anticancer drugs available, cancer cannot be cured; especially at the late stages without showing any side effect. Heterocyclic compounds exhibit exciting medicinal properties including anticancer. Some market selling heterocyclic anticancer drugs include 5-flourouracil, methortrexate, doxorubicin, daunorubicin, etc. Besides, some natural products such as vinblastine and vincristine are also used as anticancer drugs. Overall, heterocyclic moeities have always been core parts in the expansion of anticancer drugs. This article describes the importance of heterocyclic nuclei in the development of anticancer drugs. Besides, the attempts have been made to discuss both naturally occurring and synthetic heterocyclic compounds as anticancer agents. In addition, some market selling anticancer heterocyclic compounds have been described. Moreover, the efforts have been made to discuss the mechanisms of actions and recent advances in heterocyclic compounds as anticancer agents. The current challenges and future prospectives of heterocyclic compounds have also been discussed. Finally, the suggestions for syntheses of effective, selective, fast and human friendly anticancer agents are discussed into the different sections.
Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi-110025, India. drimran.chiral@gmail.com.
Imran
I
Ali
Mohammad Nadeem
MN
Lone
Zeid A
ZA
Al-Othman
Abdulrahman
A
Al-Warthan
Mohd Marsin
MM
Sanagi
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D018736:DNA Adducts / Q000378:metabolism; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000145:classification / Q000494:pharmacology*; D006801:Humans
D000970:Antineoplastic Agents; D018736:DNA Adducts; D006571:Heterocyclic Compounds