Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury.
A model of cerebral ischemia and reperfusion was established in mice. Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion. Ketamine did not remarkably change infarct volume in mice immediately following ischemia, but injection immediately following ischemia/reperfusion significantly decreased infarct volume. Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus, but nuclear factor kappa B expression was unaltered. In addition, the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion. These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus.
Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China.
Feng
F
Xiao
Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Liangzhi
L
Xiong
Department of Anesthesiology, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, China.
Qingxiu
Q
Wang
Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China.
Long
L
Zhou
Department of Anesthesiology, People's Hospital Affiliated to Wuhan University Medical College, Wuhan 430070, Hubei Province, China.
Qingshan
Q
Zhou
c-Jun; infarct volume; ischemia/reperfusion; ketamine; nuclear factor kappa B