[Evaluation of esophageal cancer treatment for patients aged over 80 years].
We examined the effectiveness of chemoradiotherapy for esophageal cancer patients aged 80 years or older, 9 of whom were treated after 2010. Treatment consisted of cisplatin 35 mg/m² (day 1 and 29) and 5-FU 350 mg/m² (days 1-4 and 29- 32) combined with 50.4 Gy radiotherapy (1.8 Gy/day, 5 days/week, days 1-42). We administered 50% of the normal dose of chemotherapy. Median survival was 387 days, and there were 6 PRs, 1 SD, and 2 PDs. The toxicities related to the chemoradiotherapy were manageable (7 patients had toxicities worse than Grade 2, of whom 6 died and 3 were alive at the time of reporting). This treatment may be effective and safe for elderly esophageal cancer patients.
Dept. of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center.
So
S
Katayanagi
Kenichi
K
Iwasaki
Tetsuo
T
Sumi
Shingo
S
Tachibana
Yoshiaki
Y
Oosaka
Motohide
M
Shimazu
Akihiko
A
Tsuchida
Shigeyuki
S
Kawachi
D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D002945:Cisplatin; D005472:Fluorouracil