Cellular interactions in the pathogenesis of interstitial lung diseases.
Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis.
Unità Operativa di Reumatologia, Dipartimento di Medicina Clinica e Sperimentale, Azienda Ospedaliera Universitaria Gaetano Martino, Università degli studi di Messina, Messina, Italy gianbagnato@gmail.com.
Gianluca
G
Bagnato
Unità Operativa di Pneumologia e Terapia Semi-Intensiva Respiratoria - Servizio di Fisiopatologia Respiratoria ed Emodinamica Polmonare-Ospedale San Giuseppe MultiMedica, Milan, Italy.
Sergio
S
Harari
D000917:Antibody Formation; D017209:Apoptosis / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D042783:Endothelial Cells / Q000502:physiology; D066026:Endothelial Progenitor Cells / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology; D005347:Fibroblasts / Q000502:physiology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology / Q000473:pathology*; D008214:Lymphocytes / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D008648:Mesoderm / Q000166:cytology; D009000:Monocytes / Q000502:physiology; D058628:Myofibroblasts / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D020286:Pericytes / Q000502:physiology; D018418:Th2 Cells / Q000502:physiology