Multifaceted Modulation of SIRT1 in Cancer and Inflammation.
SIRT1 is a highly conserved NAD+-dependent protein deacetylase that is involved in diverse cellular processes. SIRT1 can deacetylate not only histones, but also a growing number of nonhistone substrates involved in multiple signaling pathways. Accumulating evidence has indicated that SIRT1 is a key regulator of life span extension, DNA damage, metabolism stress, inflammation, and cancer. In inflammation, SIRT1 deacetylates several transcription factors and regulates the immune cell responses. In cancer, recent discoveries revealed opposite effects of SIRT1 as an oncoprotein or a tumor suppressor under different conditions. In the tumor microenvironment, both infiltrated immune cells and cancer cells can be affected by SIRT1. Understanding the proper cancer-related functions of SIRT1 in both systems may provide potential evidence for SIRT1-based therapies. Here, we discuss the current understanding of SIRT1 in regulating immune responses and tumorigenesis.
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Hui
H
Yang
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China.
Yujing
Y
Bi
Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing China.
Lixiang
L
Xue
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Jian
J
Wang
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Yun
Y
Lu
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Zhengguo
Z
Zhang
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Xi
X
Chen
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Yiwei
Y
Chu
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing China.
Ruifu
R
Yang
Center for Childhood Cancer & Blood Diseases, The Research Institute at Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA.
Ruoning
R
Wang
Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai China; Biotherapy Research Center, Institute of Immunobiology, Fudan University.
Guangwei
G
Liu
D000818:Animals; D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D055633:Immune System Phenomena / Q000235:genetics; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D015398:Signal Transduction / Q000235:genetics; D056564:Sirtuin 1 / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000502:physiology
D056564:Sirtuin 1