Chemotherapy-induced peripheral neuropathy.
Chemotherapy-induced peripheral neuropathy (CIPN) is common in patients receiving anticancer treatment and can affect survivability and long-term quality of life of the patient following treatment. The symptoms of CIPN primarily include abnormal sensory discrimination of touch, vibration, thermal information, and pain. There is currently a paucity of pharmacological agents to prevent or treat CIPN. The lack of efficacious therapeutics is due, at least in part, to an incomplete understanding of the mechanisms by which chemotherapies alter the sensitivity of sensory neurons. Although the clinical presentation of CIPN can be similar with the various classes of chemotherapeutic agents, there are subtle differences, suggesting that each class of drugs might induce neuropathy via different mechanisms. Multiple mechanisms have been proposed to underlie the development and maintenance of neuropathy; however, most pharmacological agents generated from preclinical experiments have failed to alleviate the symptoms of CIPN in the clinic. Further research is necessary to identify the specific mechanisms by which each class of chemotherapeutics induces neuropathy.
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA; Department of Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: jfehrenb@iu.edu.
Jill C
JC
Fehrenbacher
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D035843:Biomedical Research; D004195:Disease Models, Animal; D004358:Drug Therapy; D006801:Humans; D008959:Models, Neurological; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*
D000970:Antineoplastic Agents
Bortezomib; Chemotherapy; Cisplatin; Mechanisms; Neuropathy; Oxaliplatin; Paclitaxel; Pain; Peripheral sensory neuron; Vinca alkaloids