Using regional homogeneity to reveal altered spontaneous activity in patients with mild cognitive impairment.
Most patients with mild cognitive impairment (MCI) are thought to be in an early stage of Alzheimer's disease (AD). Resting-state functional magnetic resonance imaging reflects spontaneous brain activity and/or the endogenous/background neurophysiological process of the human brain. Regional homogeneity (ReHo) rapidly maps regional brain activity across the whole brain. In the present study, we used the ReHo index to explore whole brain spontaneous activity pattern in MCI. Our results showed that MCI subjects displayed an increased ReHo index in the paracentral lobe, precuneus, and postcentral and a decreased ReHo index in the medial temporal gyrus and hippocampus. Impairments in the medial temporal gyrus and hippocampus may serve as important markers distinguishing MCI from healthy aging. Moreover, the increased ReHo index observed in the postcentral and paracentral lobes might indicate compensation for the cognitive function losses in individuals with MCI.
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Yumei
Y
Wang
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Xiaochuan
X
Zhao
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Shunjiang
S
Xu
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Lulu
L
Yu
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Lan
L
Wang
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Mei
M
Song
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Linlin
L
Yang
Department of Psychiatry, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China ; Institute of Mental Health, Hebei Medical University, Shijiazhuang 050031, China.
Xueyi
X
Wang
D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male