Moderate weight loss in obese and overweight men preserves bone quality.
BACKGROUND
Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women.


OBJECTIVE
In this prospective controlled trial, we examined variables of bone quality and endocrine changes after intentional WL in men.


METHODS
Thirty-eight overweight and obese [mean ± SD body mass index (in kg/m²): 31.9 ± 4.4; age: 58 ± 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo.


RESULTS
There was a -7.9 ± 4.4% and +0.2 ± 1.6% change in body weight in the WL and WM groups, respectively. There was a greater increase in femoral neck and total body BMD and bone mineral content (BMC) in the WM group than in the WL group (P-interaction effect < 0.05). In contrast, there was a trend for the tibia cortical thickness and area to decrease more in the WM group than in the WL group (P ≤ 0.08). There was a decrease in the periosteal circumference in both groups over time (P < 0.01) and no statistically significant changes in trabecular bone. Circulating total, free, and bioavailable estradiol decreased in the WL group compared with the WM group, and changes were different between groups (P < 0.05). Serum total and bioavailable testosterone increased in both groups (P < 0.01). Serum 25-hydroxyvitamin D increased to a similar extent in both groups (P < 0.05).


CONCLUSIONS
Moderate WL in overweight and obese men did not decrease BMD at any anatomical site or alter cortical and trabecular bone and geometry. Also, despite increased BMD at some sites when maintaining excess body weight, cortical bone showed a trend in the opposite direction.
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
L Claudia
LC
Pop
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Deeptha
D
Sukumar
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Katherine
K
Tomaino
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Yvette
Y
Schlussel
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Stephen H
SH
Schneider
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Chris L
CL
Gordon
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Xiangbing
X
Wang
From the Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ (LCP, DS, KT, YS, and SAS); the Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ (SHS and XW); and the Department of Radiology, McMaster University, Hamilton, Ontario, Canada (CLG).
Sue A
SA
Shapses
D015502:Absorptiometry, Photon; D000368:Aged; D001521:Behavior Therapy; D015992:Body Mass Index; D015519:Bone Density; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D031204:Caloric Restriction / Q000009:adverse effects; D003131:Combined Modality Therapy / Q000009:adverse effects; D004038:Diet, Reducing / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009515:New Jersey / Q000453:epidemiology; D052756:Nutritional Sciences / Q000193:education; D009765:Obesity / Q000178:diet therapy* / Q000503:physiopathology / Q000628:therapy; D050177:Overweight / Q000178:diet therapy* / Q000503:physiopathology / Q000628:therapy; D010353:Patient Education as Topic; D012306:Risk; D013977:Tibia / Q000000981:diagnostic imaging; D015431:Weight Loss
bone; caloric restriction; men; obesity; sex steroids