Regulation of tissue morphodynamics: an important role for actomyosin contractility.
Forces arising from contractile actomyosin filaments help shape tissue form during morphogenesis. Developmental events that result from actomyosin contractility include tissue elongation, bending, budding, and collective migration. Here, we highlight recent insights into these morphogenetic processes from the perspective of actomyosin contractility as a key regulator. Emphasis is placed on a range of results obtained through live imaging, culture, and computational methods. Combining these approaches in the future has the potential to generate a robust, quantitative understanding of tissue morphodynamics.
Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Michael J
MJ
Siedlik
Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, United States; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, United States. Electronic address: celesten@princeton.edu.
Celeste M
CM
Nelson
D000205:Actomyosin / Q000502:physiology*; D001696:Biomechanical Phenomena; D002465:Cell Movement / Q000502:physiology; D019295:Computational Biology / Q000379:methods*; D015509:Developmental Biology / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods*; D009024:Morphogenesis / Q000502:physiology*
D000205:Actomyosin