The (phospho) needle in the (MELT) Haystack.
The spindle assembly checkpoint promotes chromosome bi-orientation and halts mitotic progression in the presence of improper kinetochore-microtubule attachments. Knl1, a kinetochore protein, acts as a scaffold for SAC signaling. A new study unveils remarkable complexity in the interplay of Knl1 phosphorylation and SAC function (Vleugel et al., 2015).
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany.
Alex C
AC
Faesen
Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Universitätsstrasse, 45141 Essen, Germany. Electronic address: andrea.musacchio@mpi-dortmund.mpg.de.
Andrea
A
Musacchio
D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008938:Mitosis; D000075223:Poly-ADP-Ribose Binding Proteins; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
C489444:BUB3 protein, human; D018797:Cell Cycle Proteins; C472643:Knl1 protein, human; D008869:Microtubule-Associated Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; C584277:BUB1 protein, human; D017346:Protein Serine-Threonine Kinases