Spontaneous and post-treatment HCV clearance: relationships with health-related quality of life in HIV infection (ANRS-VESPA2 study).
BACKGROUND
Post-treatment clearance of HCV is associated with improved health-related quality of life (HRQL) in HIV-HCV co-infection. However, the potential differences in HRQL between post-treatment and spontaneous clearers remain poorly documented.


METHODS
Linear regression models were used to assess the relationships between HCV status and HRQL (PROQOL-HIV scale) in 411 co-infected adults followed-up in French hospitals in 2011 (ANRS-VESPA2 survey).


RESULTS
After adjustment for socio-economic and clinical factors, patients previously exposed to HCV treatment showed better physical HRQL and better experience of HIV treatment than treatment-naive HCV-chronic patients. Post-treatment clearers showed better mental HRQL. Spontaneous clearers showed better experience of HIV treatment.


CONCLUSIONS
Spontaneous and post-treatment HCV clearance may influence different dimensions of HRQL of HIV-HCV co-infected patients. Further studies in real-life settings are needed to document patient-reported outcomes in the era of direct-acting antiviral agents for HCV treatment.
INSERM, UMR912 (SESSTIM), 13006, Marseille, France.
Fabienne
F
Marcellin
Baptiste
B
Demoulin
Bruno
B
Spire
Marie
M
Suzan-Monti
Perrine
P
Roux
Camelia
C
Protopopescu
Luis
L
Sagaon-Teyssier
Martin
M
Duracinsky
Rosemary
R
Dray-Spira
Maria Patrizia
MP
Carrieri
D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy* / Q000523:psychology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000523:psychology; D006306:Health Surveys; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012075:Remission, Spontaneous; D016896:Treatment Outcome
D000998:Antiviral Agents
HCV; HCV treatment; HIV; PROQOL-HIV; co-infection; health-related quality of life; spontaneous clearance