[Successful treatment of advanced gallbladder cancer involving the extrahepatic bile duct with neoadjuvant chemoradiation therapy - a case report].
A 57-year-old man with jaundice was diagnosed as having advanced gallbladder cancer involving the extrahepatic bile duct.We initiated neoadjuvant chemoradiation therapy with 3-dimensional conformal irradiation (2 Gy × 25 Fr/5 weeks)and gemcitabine (1,000 mg/m²) on days 1, 8, and 15, every 28 days for 3 courses. After percutaneous transhepatic portal vein embolization (PTPE), we performed right hepatectomy with extrahepatic bile duct resection. A follow-up examination 5 years after the operation showed no evidence of recurrence. Therefore, neoadjuvant chemoradiation therapy has the potential to improve the prognosis of patients with advanced gallbladder cancer involving the extrahepatic bile duct.
Dept. of Gastrointestinal Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease.
Kunihito
K
Gotoh
Shigeru
S
Marubashi
Shogo
S
Kobayashi
Hidenori
H
Takahashi
Hirofumi
H
Akita
Keijirou
K
Sugimura
Norikatsu
N
Miyoshi
Masaaki
M
Motoori
Kentaro
K
Kishi
Shingo
S
Noura
Yoshiyuki
Y
Fujiwara
Masayuki
M
Ohue
Yasuhiko
Y
Tomita
Masahiko
M
Yano
Osamu
O
Ishikawa
Masato
M
Sakon
D017734:Bile Ducts, Extrahepatic / Q000473:pathology / Q000601:surgery*; D059248:Chemoradiotherapy; D004621:Embolization, Therapeutic; D005706:Gallbladder Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007565:Jaundice / Q000209:etiology; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis