Neonatal late-onset sepsis following peripherally inserted central catheter removal: association with antibiotic use and adverse line events.
The objective of the study was to evaluate incidence of and risk factors for sepsis following peripherally inserted central catheter (PICC) removal. The retrospective cohort study looked at neonatal intensive care unit patients with PICC placement between February 2003 and June 2010 at a single medical center in the United States. Results showed that 14/216 patients (6.5%) had sepsis within 5 days of PICC removal. PICC removal because of adverse events was significantly associated with sepsis (P = .017). Antibiotic use before PICC removal did not have a significant impact on sepsis. The conclusions of the study are that removal of PICCs because of adverse events is significantly associated with late-onset neonatal sepsis and that antibiotic use at the time of PICC removal is not associated with a decline in sepsis rate.
Golisano Children's Hospital, Fort Meyers, Florida (Dr Hoffman); University of Nebraska Medical Center, Omaha, Nebraska (Drs Snowden, Simonsen, and Anderson-Berry and Ms Lyden); and Methodist Health Clinics, Omaha, Nebraska (Dr Nenninger). Michelle A. Hoffman, MD, is a physician in the Pediatric Infectious Disease Department of Golisano Children's Hospital of Southwest Florida in Fort Meyers, Florida. Jessica N. Snowden, MD, is an assistant professor of pediatric infectious disease in the Departments of Pediatrics and Pathology and Microbiology at the University of Nebraska Medical Center in Omaha, Nebraska. Kari A. Simonsen, MD, is an associate professor of pediatric infectious disease and division chief of pediatric infectious disease at the University of Nebraska Medical Center in Omaha, Nebraska. Tabitha M. Nenninger, MD, is a pediatric physician in internal medicine at Methodist Health Clinics in Omaha, Nebraska. Elizabeth R. Lyden, MS, works in the Department of Biostatistics at the University of Nebraska Medical Center in Omaha, Nebraska. Ann L. Anderson-Berry, MD, is an associate professor of neonatology in the Department of Pediatrics at the University of Nebraska Medical Center in Omaha, Nebraska.
Michelle A
MA
Hoffman
Jessica N
JN
Snowden
Kari A
KA
Simonsen
Tabitha M
TM
Nenninger
Elizabeth R
ER
Lyden
Ann L
AL
Anderson-Berry
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology*
D000900:Anti-Bacterial Agents