Genetic associations in PLEKHA7 and COL11A1 with primary angle closure glaucoma: a meta-analysis.
BACKGROUND
Single nucleotide polymorphisms (SNPs) rs11024102 in PLEKHA7 and rs3753841 in COL11A1 were identified to be associated with primary angle closure glaucoma (PACG) by a recent large genome-wide association study. This present study is to evaluate the association of PLEKHA7 rs11024102 and COL11A1 rs3753841 with PACG.


METHODS
A systematic review and meta-analysis.


METHODS
A total of 25 271 subjects (4895 PACG patients and 20 376 controls) in different ethnicities were tested for PLEKHA7 rs11024102 and COL11A1 rs3753841.


METHODS
A comprehensive literature search was conducted on studies published up to July 2014. Summary odds ratios (ORs) and 95% confidence intervals were analysed. Publication bias of the included articles was evaluated using funnel plots and Egger's test.


METHODS
OR for the effects of PLEKHA7 rs11024102 and COL11A1 rs3753841 on PACG risk.


RESULTS
Four eligible articles were included in this study for meta-analysis. The overall result showed that SNPs rs11024102 and rs3753841 were statistically associated with PACG (P < 0.001) in fixed-effects model. Stratified analyses showed that the association of PLEKHA7 rs11024102 and COL11A1 rs3753841 with PACG was statistically significant in Asian population (including South Indian cohort) (P < 0.001). In Caucasian population, significant association of COL11A1 rs3753841 with PACG was detected (P = 0.004), but PLEKHA7 rs11024102 did not show any association with PACG (P = 0.140).


CONCLUSIONS
This meta-analysis suggests that PLEKHA7 rs11024102 is associated with PACG in Asian population and COL11A1 rs3753841 has a genetic association with the development of PACG both in Caucasian and Asian populations.
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Ping
P
Shuai
School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.|Department of Ophthalmology, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Man
M
Yu
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Xiulan
X
Li
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yu
Y
Zhou
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Xiaoqi
X
Liu
Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Yuping
Y
Liu
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
DingDing
D
Zhang
Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.|School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Bo
B
Gong
D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D024161:Collagen Type XI / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015812:Glaucoma, Angle-Closure / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics*
C574182:COL11A1 protein, human; D002352:Carrier Proteins; D024161:Collagen Type XI; C533786:PLEKHA7 protein, human
COL11A1; PACG; PLEKHA7; SNP; meta-analysis