Gastrodin blocks neural stem cell differentiation into glial cells mediated by kainic acid.
Kainic acid can simulate excitatory amino acids in vitro. Neural stem cells, isolated from newborn Wistar rats, were cultured in vitro and exposed to 100-4 000 μM kainic acid for 7 days to induce neuronal cell differentiation, causing the number of astrocytes to be significantly increased. Treatment with a combination of 0.5 mg/L gastrodin and kainic acid also caused the number of differentiated neurons to be significantly increased compared with treatment with kainic acid alone. Experimental findings suggest that gastrodin reduces the excitability of kainic acid and induces neural stem cell differentiation into neurons.
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Guifang
G
Sun
Department of Urology, the Third People's Hospital of Zhengzhou, Zhengzhou 450051, Henan Province, China.
Zhihao
Z
Yuan
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Boai
B
Zhang
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yanjie
Y
Jia
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yangfei
Y
Ji
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Xingrong
X
Ma
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yu
Y
Liu
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yanru
Y
Liu
Department of Neurology, the Central Hospital of Nanyang, Nanyang 473009, Henan Province, China.
Quanqing
Q
Wen
Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Yanling
Y
Zhao
differentiation; gastrodin; kainic acid; neural stem cells