A highly porous medical metal-organic framework constructed from bioactive curcumin.
A highly porous bio-MOF, medi-MOF-1, constructed from Zn and the pharmaceutical ingredient curcumin has been successfully synthesized. It can display permanent porosity with a surface area as high as ca. 3002 m(2) g(-1), which exhibits great potential in bioapplications. Its ibuprofen delivery ability, biodegradation and cytotoxicity were also studied.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China. zhugs@jlu.edu.cn.
Hongmin
H
Su
Fuxing
F
Sun
Jiangtao
J
Jia
Hongming
H
He
Aifei
A
Wang
Guangshan
G
Zhu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016503:Drug Delivery Systems; D006801:Humans; D007052:Ibuprofen / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D010316:Particle Size; D016062:Porosity; D013329:Structure-Activity Relationship; D013499:Surface Properties
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D009942:Organometallic Compounds; D003474:Curcumin; D007052:Ibuprofen