Tumor biology: with a little help from my dying friends.
Apoptosis is an essential form of cell death underlying daily tissue regeneration. In tumor biology, apoptosis resistance is a well-established hallmark of cancer that is targeted by therapeutic approaches. A new study assigns a hitherto-underestimated function to this 'deadly friend': apoptotic cells promote tumor growth, accumulation of tumor-associated macrophages, and angiogenesis.
Clinic for Radiotherapy and Radiation Oncology, Ludwig-Maximilians-University Munich, Germany. Electronic address: kirsten.lauber@med.uni-muenchen.de.
Kirsten
K
Lauber
Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.
Martin
M
Herrmann
D017209:Apoptosis / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000503:physiopathology*; D010586:Phagocytes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D059016:Tumor Microenvironment / Q000502:physiology*