Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.
Bioassay guided fractionation of Hypericum riparium leaves extract has resulted in the isolation and characterization of three new compounds namely chipericumin E (1), hyperenone C (3), and hyperixanthone (5), together with twenty known compounds. Their structures were elucidated based on comprehensive interpretation of spectroscopic and spectrometric data. Compounds 1-4, and 6-8 displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxic effects on the human gastric cell line BGC-823 with IC50 values ranging from 6.54 to 18.50μM.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address: ftalamichel@gmail.com.
Michel Feussi
MF
Tala
Institute of Environmental Research (INFU) of the Faculty of Chemistry, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Ferdinand Mouafo
FM
Talontsi
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Guang-Zhi
GZ
Zeng
Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Hippolyte Kamdem
HK
Wabo
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China. Electronic address: nhtan@mail.kib.ac.cn.
Ning-Hua
NH
Tan
Institute of Environmental Research (INFU) of the Faculty of Chemistry, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Michael
M
Spiteller
Department of Chemistry, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Pierre
P
Tane
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts; D013141:Spiro Compounds; D044004:Xanthones; C000598390:chipericumin E; C000598391:hyperenone C; C000598392:hyperixanthone
Antimicrobial; Butenolide; Cytotoxicity; Hypericum riparium; Phloroglucinols; Xanthones