Anti-N antibody reacting at 37°C: An unusual occurrence interfering with routine testing: Two interesting cases.
Most anti-N antibodies are naturally occurring, IgM antibodies, and not active above 25°C and are not clinically significant but IgG anti- N has also been described. Immune anti-N resulting from multiple transfusions does occur & has been implicated as the cause of hemolytic transfusion reactions and mild hemolytic disease of fetus and newborn. Anti- N reacting at room temperature can be a cause for ABO blood group discrepancy.
Department of Transfusion Medicine, Citizens Hospital, Nallagandla, Serilingampally, Hyderabad, India.
Vijay
V
Kumawat
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ashish
A
Jain
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Neelam
N
Marwaha
Department of Transfusion Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Ratti Ram
RR
Sharma
Anti-N antibody; naturally occurring anti-N; warm reacting antibody