Elemental diet induces the proliferation of sialomucin goblet cells in the rat duodenum and jejunum.
We histologically examined the effects of elemental diet (ED) on the goblet cell profile in the rat small intestine. The sulfomucin goblet cells were predominant throughout the small intestine in the control group, while sialomucin goblet cells were manifest in the duodenum and jejunum in the ED group. Next, we investigated the possible relevance of luminal osmolality to the goblet cell profile. Gastric osmolality in the ED group was within the physiological range. Meanwhile, ingestion of high glucose diet elevated gastric osmolality and increased the number of sialomucin goblet cells in the duodenum and jejunum. Further, it turned out that the lower sulfur contents in ED was not related to the unique goblet cell profile by ED ingestion. It is inductively suggested that the influx of high concentrations of low molecular nutrients into the small intestine could be associated with the goblet cell alteration, but the alteration was not necessarily due to the changes in the gastric osmolality by ED ingestion.
a Department of Applied Biological Chemistry , Graduate School of Agriculture, Shizuoka University , Shizuoka , Japan.
Shingo
S
Hino
Ayano
A
Ito
Takashi
T
Kondo
Tatsuya
T
Morita
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004386:Duodenum / Q000166:cytology* / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005526:Food, Formulated / Q000009:adverse effects*; D020397:Goblet Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007583:Jejunum / Q000166:cytology* / Q000187:drug effects; D009994:Osmolar Concentration; D051381:Rats; D052116:Sialomucins / Q000378:metabolism*; D013455:Sulfur / Q000009:adverse effects / Q000032:analysis
D052116:Sialomucins; D013455:Sulfur
elemental diet; rat; sialomucin; sulfomucin