Circadian biology: rhythms leave their imprint.
A recent study has revealed that loss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome results in selective neuronal loss of robust circadian oscillations, with a resulting behavioural phenotype, and adipose tissue accumulation.
Faculty of Medical and Health Sciences, University of Manchester, Manchester, UK. Electronic address: david.w.ray@manchester.ac.uk.
David W
DW
Ray
D017204:Angelman Syndrome / Q000503:physiopathology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D044767:Ubiquitin-Protein Ligases