Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives.
Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies.
Cardiology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Spain.
Irene
I
Santos-Pardo
Cardiology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Spain.
Roger
R
Villuendas
Immunology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), FOCIS-CE, Spain.
Iñaki
I
Salvador-Corres
Rheumatology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Spain.
Melania
M
Martínez-Morillo
Rheumatology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Spain; Department of Medicine, Universitat Autònoma de Barcelona (UAB), Spain.
Alejandro
A
Olivé
Cardiology Service, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona (UAB), Spain; Department of Medicine, Universitat Autònoma de Barcelona (UAB), Spain.
Antoni
A
Bayes-Genis
D001145:Arrhythmias, Cardiac / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005544:Forecasting; D006801:Humans; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000097:blood*; D000099207:SS-A Antigen
D001323:Autoantibodies; D015415:Biomarkers; D012261:Ribonucleoproteins; D000099207:SS-A Antigen
Anti-Ro/SSA; Cardiac rhythm disturbances; Pathogenesis