ALT telomeres get together with nuclear receptors.
Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI).
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
Eric
E
Aeby
Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: joachim.lingner@epfl.ch.
Joachim
J
Lingner
D042822:Genomic Instability; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*
D016194:Receptors, N-Methyl-D-Aspartate