[Microtubular disrupter nocodazole and vesicular transport inhibitor brefeldin A attenuate the glutoxim effect on Na+ transport in frog skin].
Using the voltage-clamp technique, a possible role of microtubules and vesicular transport in the effect of pharmacological analogue of oxidized glutathione, drug glutoxim, on Na+ transport in the frog Rana temporaria skin was investigated. It was shown for the first time that the disrupter of microtubules nocodazole or inhibitor of vesicular transport brefeldin A similarly modulate (completely inhibit) the stimulatory effect of glutoxim on Na+ transport. The data suggest the involvement of reorganization of microtubules and vesicular transport in the regulatory effect of glutoxim on Na+ transport. .
A V
AV
Mel'nitskaia
Z I
ZI
Krutetskaia
S N
SN
Butov
N I
NI
Kutetskaia
V G
VG
Antonov
D000818:Animals; D020126:Brefeldin A / Q000494:pharmacology*; D017136:Ion Transport / Q000187:drug effects; D015739:Nocodazole / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011896:Rana temporaria; D012867:Skin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D050257:Tubulin Modulators / Q000494:pharmacology*
D009842:Oligopeptides; D011500:Protein Synthesis Inhibitors; D050257:Tubulin Modulators; C462699:glutoxim; D020126:Brefeldin A; D012964:Sodium; D015739:Nocodazole