Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites.
Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Mostafa E
ME
Rateb
Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Dong
D
Yang
Biotechnology and Bioengineering Center and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Sanja
S
Vodanovic-Jankovic
Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.
Zhiguo
Z
Yu
Biotechnology and Bioengineering Center and Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
Michael A
MA
Kron
Department of Chemistry, The Scripps Research Institute, Jupiter, FL, USA.|Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, USA.|Natural Products Library Initiative, The Scripps Research Institute, Jupiter, FL, USA.
Ben
B
Shen
D000818:Animals; D001226:Aspartate-tRNA Ligase / Q000037:antagonists & inhibitors*; D017178:Brugia malayi / Q000187:drug effects* / Q000201:enzymology*; D005369:Filaricides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012346:RNA, Transfer, Amino Acyl / Q000037:antagonists & inhibitors*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D016019:Survival Analysis
D005369:Filaricides; D012346:RNA, Transfer, Amino Acyl; D012118:Resorcinols; D001226:Aspartate-tRNA Ligase; C029194:asparaginyl-tRNA synthetase