Suppression of antibiotic resistance acquisition by combined use of antibiotics.
We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance.
Laboratory for Multiscale Biosystem Dynamics, Quantitative Biology Center (QBiC), RIKEN, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.
Shingo
S
Suzuki
Laboratory for Multiscale Biosystem Dynamics, Quantitative Biology Center (QBiC), RIKEN, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan.
Takaaki
T
Horinouchi
Laboratory for Multiscale Biosystem Dynamics, Quantitative Biology Center (QBiC), RIKEN, 6-2-3 Furuedai, Suita, Osaka 565-0874, Japan. Electronic address: Chikara.furusawa@riken.jp.
Chikara
C
Furusawa
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D005075:Biological Evolution; D019020:Directed Molecular Evolution; D004352:Drug Resistance, Microbial / Q000187:drug effects*; D004359:Drug Therapy, Combination; D004926:Escherichia coli / Q000187:drug effects* / Q000378:metabolism*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents
Antibiotics; Escherichia coli; Experimental evolution; Resistance; Trade-off