Mucormycosis in a Non-Hodgkin Lymphoma Patient Caused by Syncephalastrum racemosum: Case Report and Review of Literature.
Mucormycosis is a rare opportunistic fungal infection caused by saprophytic zygomycetes. These fungal infections are caused by members of the mucorales. The clinical importance of zygomycosis, an emerging and frequently fatal mycotic disease, has increased during recent years, due to several risk factors such as (a) the use of broad-spectrum antibiotic, (b) use of empirical antifungal treatment (mainly triazoles), and (c) aggressive chemotherapy and sustained leucopenia (i.e., peripheral stem cell transplantation). An almost fulminant pneumonia caused by Syncephalastrum racemosum in an immunocompromised patient with an aggressive non-Hodgkin lymphoma (NHL) is described. Despite treatment with amphotericin B, deoxycholate, caspofungin, and surgical resection of fungal bodies from both lungs, and survival of 10 months without relapsing from fungal infection, the patient died due to hematological complications from an unresponsive disease. Herein is the description of the first case of pulmonary infection caused by Syncephalastrum racemosum.
Servicio de Dermatología, Hospital General Dr. Manuel Gea González, 14080, Tlalpan, Mexico, Mexico.
Georgina
G
Rodríguez-Gutiérrez
Erika M
EM
Carrillo-Casas
Roberto
R
Arenas
Jorge O
JO
García-Méndez
Sonia
S
Toussaint
Mónica E
ME
Moreno-Morales
Adrián A
AA
Schcolnik-Cabrera
Juan
J
Xicohtencatl-Cortes
Rigoberto
R
Hernández-Castro
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D003646:Debridement; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008853:Microscopy; D009090:Mucorales / Q000302:isolation & purification*; D009091:Mucormycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology* / Q000628:therapy
D000935:Antifungal Agents