Pharmacotherapy for alcohol use disorder: current and emerging therapies.
Alcohol use disorder is a heterogeneous illness with a complex biology that is controlled by many genes and gene-by-environment interactions. Several efficacious, evidence-based treatments currently exist for treating and managing alcohol use disorder, including a number of pharmacotherapies that target specific aspects of biology that initiate and maintain dangerous alcohol misuse. This article reviews the neurobiological and neurobehavioral foundation of alcohol use disorder, the mechanisms of action and evidence for the efficacy of currently approved medications for treatment, and the literature on other emerging pharmacotherapies.
From the Department of Psychiatry and Human Behavior, Brown University Alpert School of Medicine (Dr. Swift); Center for Alcohol and Addiction Studies, Brown University School of Public Health (Drs. Swift and Aston); VA Medical Center, Providence, RI (Dr. Swift).
Robert M
RM
Swift
Elizabeth R
ER
Aston
D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000428:Alcohol Drinking; D002986:Clinical Trials as Topic; D005062:European Union; D006801:Humans; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D014481:United States
D000427:Alcohol Deterrents; D009292:Narcotic Antagonists