Spatial and temporal dynamics of the cardiac mitochondrial proteome.
Mitochondrial proteins alter in their composition and quantity drastically through time and space in correspondence to changing energy demands and cellular signaling events. The integrity and permutations of this dynamism are increasingly recognized to impact the functions of the cardiac proteome in health and disease. This article provides an overview on recent advances in defining the spatial and temporal dynamics of mitochondrial proteins in the heart. Proteomics techniques to characterize dynamics on a proteome scale are reviewed and the physiological consequences of altered mitochondrial protein dynamics are discussed. Lastly, we offer our perspectives on the unmet challenges in translating mitochondrial dynamics markers into the clinic.
Department of Physiology, The NHLBI Proteomics Center at UCLA, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Edward
E
Lau
Derrick
D
Huang
Quan
Q
Cao
T Umut
TU
Dincer
Caitie M
CM
Black
Amanda J
AJ
Lin
Jessica M
JM
Lee
Ding
D
Wang
David A
DA
Liem
Maggie P Y
MP
Lam
Peipei
P
Ping
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
D015415:Biomarkers; D024101:Mitochondrial Proteins; D020543:Proteome
cardiovascular disease; mitochondria; protein dynamics; spatial dynamics; temporal dynamics