HIV-1 Nef drives macrophages into hiding.
In this issue of Blood, Vérollet et al show that expression of the HIV-1–derived protein Nef alters the migratory mode adopted by macrophages, enhancing macrophage tissue infiltration and explaining the observed accumulation of tissue-resident macrophages in some HIV-infected patients.
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE.
Sharon Celeste
SC
Morley
D000818:Animals; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D008264:Macrophages / Q000502:physiology* / Q000821:virology*; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000502:physiology*
D054311:nef Gene Products, Human Immunodeficiency Virus