Methyl 3,4-dihydroxybenzoate promotes neurite outgrowth of cortical neurons cultured in vitro.
Cerebral cortical neurons from neonatal rats were cultured in the presence of methyl 3,4-dihydroxybenzoate (MDHB; 2, 4, and 8 μM). Results showed that MDHB significantly promoted neurite outgrowth and microtubule-associated protein 2 mRNA expression, and increased neuronal survival in a dose-dependent manner. Moreover, MDHB induced brain-derived neurotrophic factor expression. These findings suggest that MDHB has a neurotrophic effect, which may be due to its ability to increase brain-derived neurotrophic factor expression.
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Zheng
Z
Zhang
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Xing
X
Zhou
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Xiaowen
X
Zhou
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Xiao
X
Xu
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Minjing
M
Liao
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Li
L
Yan
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China.
Ruohua
R
Lv
Department of Pharmacology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Science, Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health, Jinan University and the University of Hong Kong, Jinan University, Guangzhou 510632, Guangdong Province, China.
Huanmin
H
Luo
brain-derived neurotrophic factor; methyl 3,4-dihydroxybenzoate; neural regeneration; neurite outgrowth; neurodegenerative diseases