[Microbiota and autoimmunity].
The microbiota plays a fundamental role in the development and the maintenance of the host immune system. Since microbiota is important in the induction and the expansion of Th17 cells and regulatory T cells, growing evidence supports that microbiome affect the induction and the disease course of autoimmune disorders. In this review, we describe the recent studies on the involvement of microbes in animal models of autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) using germ-free conditions, antibiotics treatment and gnotobiotic mice. Furthermore, we introduce the studies on analysis of microbiota in human autoimmune diseases including RA and MS.
Department of Immunology, Juntendo University School of Medicine.
Sachiko
S
Miyake
D000818:Animals; D000900:Anti-Bacterial Agents; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D004195:Disease Models, Animal; D005856:Germ-Free Life; D006801:Humans; D007422:Intestines / Q000382:microbiology; D051379:Mice; D064307:Microbiota / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
D000900:Anti-Bacterial Agents