An update on the association of vitamin D deficiency with common infectious diseases.
Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.
Department of Internal Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Division of Infectious Diseases, Akron General Medical Center, Akron, OH 44302, USA.
Richard R
RR
Watkins
Tracy L
TL
Lemonovich
Robert A
RA
Salata
D056704:Adaptive Immunity / Q000276:immunology; D000818:Animals; D003141:Communicable Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D014807:Vitamin D / Q000276:immunology* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*
D014807:Vitamin D
HIV; MRSA; SARM; VIH; immunity; immunité; pneumonia; pneumonie; sepsis; septicémie; therapy; traitement; vitamin D; vitamine D