Neuronal prediction of opponent's behavior during cooperative social interchange in primates.
A cornerstone of successful social interchange is the ability to anticipate each other's intentions or actions. While generating these internal predictions is essential for constructive social behavior, their single neuronal basis and causal underpinnings are unknown. Here, we discover specific neurons in the primate dorsal anterior cingulate that selectively predict an opponent's yet unknown decision to invest in their common good or defect and distinct neurons that encode the monkey's own current decision based on prior outcomes. Mixed population predictions of the other was remarkably near optimal compared to behavioral decoders. Moreover, disrupting cingulate activity selectively biased mutually beneficial interactions between the monkeys but, surprisingly, had no influence on their decisions when no net-positive outcome was possible. These findings identify a group of other-predictive neurons in the primate anterior cingulate essential for enacting cooperative interactions and may pave a way toward the targeted treatment of social behavioral disorders.
Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02114, USA; Department of Neurosurgery, MGH-HMS Center for Nervous System Repair, Harvard Medical School, Boston, MA 02114, USA. Electronic address: haroush.keren@mgh.harvard.edu.
Keren
K
Haroush
Harvard-MIT Health Sciences and Technology, Harvard Medical School, Boston, MA 02114, USA; Department of Neurosurgery, MGH-HMS Center for Nervous System Repair, Harvard Medical School, Boston, MA 02114, USA. Electronic address: zwilliams@mgh.harvard.edu.
Ziv M
ZM
Williams
D000818:Animals; D003299:Cooperative Behavior; D003657:Decision Making; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology / Q000523:psychology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D011581:Psychological Tests; D012201:Reward; D012919:Social Behavior