The molecular basis of rectal cancer.
The majority of rectal carcinomas are sporadic in nature, and relevant testing for driver mutations to guide therapy is important. A thorough family history is necessary and helpful in elucidating a potential hereditary predilection for a patient's carcinoma. The adequate diagnosis of a heritable tendency toward colorectal carcinoma alters the management of a patient disease and permits the implementation of various surveillance algorithms as preventive measures.
Department of Pathology, Baylor University Medical Center at Dallas, Dallas, Texas.
Michelle
M
Shiller
Department of Surgery, Baylor University Medical Center at Dallas, Dallas, Texas.
Sarah
S
Boostrom
adenoma-carcinoma sequence; colorectal cancer; hereditary cancer; molecular testing