A mitochondrially encoded hormone ameliorates obesity and insulin resistance.
MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.
Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland.
Kim
K
Zarse
Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH), 8603 Zurich, Switzerland. Electronic address: michael-ristow@ethz.ch.
Michael
M
Ristow
D000818:Animals; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*
D010455:Peptides