Serine proteases of parasitic helminths.
Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development, and fertilization. A number of serine proteases have been identified in parasitic helminths that have putative roles in parasite development and nutrition, host tissues and cell invasion, anticoagulation, and immune evasion. In this review, we described the serine proteases that have been identified in parasitic helminths, including nematodes (Trichinella spiralis, T. pseudospiralis, Trichuris muris, Anisakis simplex, Ascaris suum, Onchocerca volvulus, O. lienalis, Brugia malayi, Ancylostoma caninum, and Steinernema carpocapsae), cestodes (Spirometra mansoni, Echinococcus granulosus, and Schistocephalus solidus), and trematodes (Fasciola hepatica, F. gigantica, and Schistosoma mansoni). Moreover, the possible biological functions of these serine proteases in the endogenous biological phenomena of these parasites and in the host-parasite interaction were also discussed.
State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China ; ANSES, ENVA, UPVM, PRES Paris Est, JRU BIPAR, Animal Health Laboratory, Maisons-Alfort, France.
Yong
Y
Yang
State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.
Yun jun
Yj
Wen
College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Ya Nan
YN
Cai
ANSES, ENVA, UPVM, PRES Paris Est, JRU BIPAR, Animal Health Laboratory, Maisons-Alfort, France.
Isabelle
I
Vallée
ANSES, ENVA, UPVM, PRES Paris Est, JRU BIPAR, Animal Health Laboratory, Maisons-Alfort, France.
Pascal
P
Boireau
Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, Jilin University, Changchun, China ; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.
Ming Yuan
MY
Liu
State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China.
Shi Peng
SP
Cheng
D000818:Animals; D002589:Cestoda / Q000145:classification / Q000201:enzymology* / Q000254:growth & development / Q000502:physiology; D006790:Host-Parasite Interactions; D008018:Life Cycle Stages; D009348:Nematoda / Q000145:classification / Q000201:enzymology* / Q000254:growth & development / Q000502:physiology; D057057:Serine Proteases / Q000235:genetics / Q000378:metabolism*; D014200:Trematoda / Q000145:classification / Q000201:enzymology* / Q000254:growth & development / Q000502:physiology
D057057:Serine Proteases
Serine protease; biological function; cestode; nematode; parasitic helminth; trematode