Measurement of internal diameter changes and pulse wave velocity in fetal descending aorta using the ultrasonic phased-tracking method in normal and growth-restricted fetuses.
Phased tracking (PT) is an ultrasound-based technique that enables precise measurement of a target velocity. The aims of this study were to use PT to evaluate arterial pulse waveform, pulse wave velocity and fetal pulse pressure in normal and growth-restricted fetuses. One hundred fetuses with normal development and 15 fetuses with growth restriction were analyzed. Ultrasonic raw radiofrequency signals were captured from a direction perpendicular to the vascular axis at the fetal diaphragmatic level for the difference in internal dimensions (DID), or simultaneously from different directions for the pulse wave velocity. Pulsatile movement of the proximal and distal intima of the vessels was analyzed using PT. The fetal DID exhibited no significant changes in growth-restricted fetuses. Pulse wave velocity (3.8 ± 0.32 m/s vs. 2.2 ± 0.069 m/s, p < 0.001) and estimated pulse pressure (6.9 ± 0.90 kPa vs. 2.5 ± 0.18 kPa, p < 0.001) were significantly elevated in growth-restricted fetuses. Assessment of DID and pulse wave velocity of the descending aorta using PT is a feasible, non-invasive approach to evaluation of fetal hemodynamics.
Department of Advanced Fetal and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Maternal and Fetal Medicine, Miyagi Children's Hospital, Sendai, Miyagi, Japan. Electronic address: ssmu.miyashita@nifty.ne.jp.
Susumu
S
Miyashita
Department of Advanced Fetal and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Maternal and Fetal Medicine, Miyagi Children's Hospital, Sendai, Miyagi, Japan.
Jun
J
Murotsuki
Department of Advanced Fetal and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Maternal and Fetal Medicine, Miyagi Children's Hospital, Sendai, Miyagi, Japan.
Jin
J
Muromoto
Department of Advanced Fetal and Developmental Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; Department of Maternal and Fetal Medicine, Miyagi Children's Hospital, Sendai, Miyagi, Japan.
Katsusuke
K
Ozawa
Department of Obstetrics and Gynecology, Tohoku University, Sendai, Miyagi, Japan.
Nobuo
N
Yaegashi
Department of Electronic Engineering, Tohoku University Graduate School of Engineering, Sendai, Miyagi, Japan.
Hideyuki
H
Hasegawa
Department of Electronic Engineering, Tohoku University Graduate School of Engineering, Sendai, Miyagi, Japan.
Hiroshi
H
Kanai
D001011:Aorta / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D063177:Pulse Wave Analysis / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal / Q000379:methods*
Fetal growth restriction; Fetal pulse pressure; Phased-tracking method; Pulse wave velocity