Rh(III)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates.
Here we report a new and mild Rh(III)-catalyzed and alcohol-involved carbenoid C-H insertion into N-phenoxyacetamides using α-diazomalonates. This reaction provided a straightforward way for installing both an α-quaternary carbon center and a free-OH moiety into the phenyl ring, thus giving access to useful 2-(2-hydroxyphenyl)-2-alkoxymalonates with good substrate/functional group tolerance.
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China.
Jie
J
Zhou
Jingjing
J
Shi
Xuelei
X
Liu
Jinlong
J
Jia
Huacan
H
Song
H Eric
HE
Xu
Wei
W
Yi
D001391:Azo Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D008314:Malonates / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D010642:Phenoxyacetates / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D001391:Azo Compounds; D008314:Malonates; D010642:Phenoxyacetates; D002244:Carbon; D012238:Rhodium; D000432:Methanol