Caffeine and headache: specific remarks.
Caffeine is the most widely used psychostimulant worldwide. Excessive caffeine consumption induces a series of both acute and chronic biological and physiological changes that may give rise to cognitive decline, depression, fatigue, insomnia, cardiovascular changes, and headache. Chronic consumption of caffeine promotes a pro-nociceptive state of cortical hyperexcitability that can intensify a primary headache or trigger a headache due to excessive analgesic use. This review offers an in-depth analysis of the physiological mechanisms of caffeine and its relationship with headache.
Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia. Electronic address: camilo_jovel@hotmail.com.
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Espinosa Jovel
Neurología, Facultad de Medicina, Universidad de la Sabana, Bogotá, Colombia; Departamento de Neurología, Hospital Occidente de Kennedy, Bogotá, Colombia.
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Sobrino Mejía
D002110:Caffeine / Q000009:adverse effects*; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D006261:Headache / Q000139:chemically induced*; D020773:Headache Disorders / Q000139:chemically induced / Q000150:complications; D006801:Humans
D000697:Central Nervous System Stimulants; D002110:Caffeine
Adenosina; Adenosine; Adultos; Adults; Analgesics; Analgésicos; Cafeína; Caffeine; Cefalea crónica diaria; Daily chronic headache; Migraine; Migraña