Biological organisation as closure of constraints.
We propose a conceptual and formal characterisation of biological organisation as a closure of constraints. We first establish a distinction between two causal regimes at work in biological systems: processes, which refer to the whole set of changes occurring in non-equilibrium open thermodynamic conditions; and constraints, those entities which, while acting upon the processes, exhibit some form of conservation (symmetry) at the relevant time scales. We then argue that, in biological systems, constraints realise closure, i.e. mutual dependence such that they both depend on and contribute to maintaining each other. With this characterisation in hand, we discuss how organisational closure can provide an operational tool for marking the boundaries between interacting biological systems. We conclude by focusing on the original conception of the relationship between stability and variation which emerges from this framework.
IHPST - UMR 8590 13, rue du Four 75006 Paris, France. Electronic address: mael.montevil@gmail.com.
Maël
M
Montévil
IHPST - UMR 8590 13, rue du Four 75006 Paris, France. Electronic address: matteo.mossio@univ-paris1.fr.
Matteo
M
Mossio
D000818:Animals; D003198:Computer Simulation; D004798:Enzymes / Q000502:physiology; D006801:Humans; D008168:Lung / Q000502:physiology; D008954:Models, Biological; D010100:Oxygen / Q000378:metabolism; D049490:Systems Biology; D013816:Thermodynamics; D013997:Time Factors
D004798:Enzymes; D010100:Oxygen
Biological organisation; Closure; Constraints; Symmetries; Time scales