Delivery of oligonucleotides with lipid nanoparticles.
Since their inception in the 1980s, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of novel ON-based therapeutics. Difficulties in the delivery of this class of therapeutics hinder their in vivo applications, which forces drug delivery systems to be a prerequisite for clinical translation. This review discusses the strategy of using lipid nanoparticles as carriers to deliver therapeutic ONs to target cells in vitro and in vivo. A discourse on how chemical and physical properties of the lipid materials could be utilized during formulation and the resulting effects on delivery efficiency constitutes the major part of this review.
Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: alwang@email.unc.edu.
Yuhua
Y
Wang
Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lei
L
Miao
Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Andrew
A
Satterlee
Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Leaf
L
Huang
D000818:Animals; D001692:Biological Transport; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes; D008107:Liver Diseases / Q000188:drug therapy / Q000378:metabolism; D008171:Lung Diseases / Q000188:drug therapy / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D013499:Surface Properties
D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D009841:Oligonucleotides
Lipid nanoparticles; Lipoplexes; Liposome; Oligonucleotides; Systemic delivery