Comparison between bacteremia caused by Acinetobacter pittii and Acinetobacter nosocomialis.
OBJECTIVE
Patients with Acinetobacter pittii and Acinetobacter nosocomialis bacteremia have lower mortality rates than those with Acinetobacter baumannii bacteremia. However, it is unknown whether these organisms differ in outcomes of bacteremic patients. We conducted this study to answer this question.


METHODS
In this retrospective study conducted at a teaching hospital in Taiwan, we enrolled all 86 patients who had developed A. pittii bacteremia and those with A. nosocomialis bacteremia from 2000 to 2008 while matching for age, sex, Acute Physiology and Chronic Health Evaluation II score, and appropriate antimicrobial therapy. After adjustment, we accessed the clinical characteristics and 14- and 28-day mortalities.


RESULTS
We found that the patients with A. pittii bacteremia had multiple comorbidities less often and received invasive procedures less frequently. The 14-day mortality rate of patients with A. pittii or A. nosocomialis bacteremia was 14% and 7%, respectively, whereas their 28-day mortality rate was 17% and 9%, respectively. Using the mortality rate in patients with A. nosocomialis bacteremia as a reference, the odds ratios for the 14- and 28-day crude morality in those with A. pittii were 2.16 [95% confidence interval (CI), 0.77-6.05] and 2.06 (95% CI, 0.82-5.15), respectively, whereas the adjusted odds ratios for 14- and 28-day mortality were 1.89 (95% CI, 0.56-6.14) and 1.67 (95% CI, 0.59-4.78) respectively.


CONCLUSIONS
Our 8-year study showed that the mortality rate of A. pittii bacteremia was higher but the difference was not statistically significant.
Division of Infectious Diseases, Changhua Christian Hospital, Changhua, Taiwan.
Yuag-Meng
YM
Liu
Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Tzu
YT
Lee
Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan; Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei, Taiwan.
Shu-Chen
SC
Kuo
Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Division of Infectious Diseases, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Infectious Diseases, Cheng Hsin General Hospital, Taipei, Taiwan.
Te-Li
TL
Chen
Division of Infectious Diseases, Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. Electronic address: joeliu5929@hotmail.com.tw.
Chang-Pan
CP
Liu
Division of Infectious Diseases, Changhua Christian Hospital, Changhua, Taiwan. Electronic address: 63557@cch.org.tw.
Chun-Eng
CE
Liu
D000150:Acinetobacter / Q000145:classification / Q000302:isolation & purification / Q000472:pathogenicity*; D000151:Acinetobacter Infections / Q000382:microbiology* / Q000401:mortality*; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality*; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan
Acinetobacter calcoaceticus–baumannii complex; Acinetobacter nosocomialis; Acinetobacter pittii; Bacteremia; Mortality