Cabergoline use for pituitary tumors and valvular disorders.
Cabergoline (CAB) is widely used for the medical treatment of pituitary tumors, particularly those associated with hormone hypersecretion. Whether treatment with CAB is associated with an increased risk of clinically relevant cardiac valve disease in patients with pituitary tumors is still debated. In most studies, CAB has been found not associated with an increased risk of significant valvulopathy, and no correlation has been shown between valvular abnormalities and CAB duration or cumulative dose. This review provides an overview of the studies reporting on the outcome of CAB in terms of cardiac valve disease in patients with pituitary tumors.
Ios-Coleman Medicina Futura Medical Center, Centro Direzionale, Naples 80143, Italy.
Renata S
RS
Auriemma
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University "Federico II", via Sergio Pansini 5, Naples 80131, Italy.
Rosario
R
Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University "Federico II", via Sergio Pansini 5, Naples 80131, Italy.
Lucia
L
Ferreri
Ios-Coleman Medicina Futura Medical Center, Centro Direzionale, Naples 80143, Italy.
Prisco
P
Priscitelli
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University "Federico II", via Sergio Pansini 5, Naples 80131, Italy. Electronic address: colao@unina.it.
Annamaria
A
Colao
D000172:Acromegaly / Q000188:drug therapy*; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D004873:Ergolines / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D006349:Heart Valve Diseases / Q000139:chemically induced*; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy*; D015175:Prolactinoma / Q000188:drug therapy*
D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline
Acromegaly; Cabergoline; Cardiac valve disease; Cushing’s disease; Dopamine-agonists; Pituitary adenoma; Prolactinoma