A comprehensive review of glycosylated bacterial natural products.
A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is presented. This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Sherif I
SI
Elshahawi
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Khaled A
KA
Shaaban
School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA.
Madan K
MK
Kharel
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Jon S
JS
Thorson
D000617:Aminoglycosides / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry* / Q000378:metabolism; D001688:Biological Products / Q000737:chemistry*; D006031:Glycosylation; D018942:Macrolides / Q000737:chemistry; D015394:Molecular Structure
D000617:Aminoglycosides; D001688:Biological Products; D018942:Macrolides; C003169:pluramycin