The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.
This review covers the initial discovery of the marine actinomycete genus Salinispora through its development as a model for natural product research. A focus is placed on the novel chemical structures reported with reference to their biological activities and the synthetic and biosynthetic studies they have inspired. The time line of discoveries progresses from more traditional bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target the products of specific biosynthetic gene clusters. This overview exemplifies the extraordinary biosynthetic diversity that can emanate from a narrowly defined genus and supports future efforts to explore marine taxa in the search for novel natural products.
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, USA. pjensen@ucsd.edu.
Paul R
PR
Jensen
Bradley S
BS
Moore
William
W
Fenical
D039903:Actinobacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008386:Marine Biology; D008954:Models, Biological; D015394:Molecular Structure; D005810:Multigene Family
D001688:Biological Products