Catechol-O-methyltransferase genotype and response to Compensatory Cognitive Training in outpatients with schizophrenia.
The catechol-O-methyltransferase (COMT) ValMet polymorphism is associated with cognitive functioning in schizophrenia and may predict cognitive training outcomes. This study aimed to explore the contribution of COMT genotype in predicting improvement following Compensatory Cognitive Training (CCT). We conducted mixed factorial analysis of variance to examine COMT genotype as a predictor of response to CCT (i.e. improved cognitive performance) in 41 participants with schizophrenia-spectrum disorders. We also explored the effect of CCT treatment and COMT genotype on psychiatric symptom severity, functional capacity, and subjective quality of life. Met carrier status did not predict CCT treatment outcomes. COMT genotype may exert only modest effects on cognitive training response. Further research with larger samples is needed to establish genetic predictors of response to cognitive training.
aSDSU/UCSD Joint Doctoral Program in Clinical Psychology, Department of Psychiatry, University of California San Diego, San Diego, California, USA bDepartment of Psychiatry, University of California San Diego, La Jolla, California, USA cPsychiatry Service, VA San Diego Healthcare System, San Diego, California, USA dCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, California, USA eSemel Institute for Neuroscience & Human Behavior, University of California, Los Angeles, California, USA.
Cynthia Z
CZ
Burton
Lea
L
Vella
John R
JR
Kelsoe
Robert M
RM
Bilder
Elizabeth W
EW
Twamley
D000328:Adult; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000628:therapy*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients / Q000523:psychology*; D020641:Polymorphism, Single Nucleotide; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000097:blood / Q000201:enzymology / Q000235:genetics* / Q000628:therapy*
D002394:Catechol O-Methyltransferase