Novel stilbenes from Artocarpus nanchuanensis.
Four new stilbene derivatives, hypargystilbenes B-E (1-4), together with seven known compounds (5-11), were isolated from the stems of Artocarpus nanchuanensis S.S. Chang. Their structures were elucidated on the basis of spectral data. Hypargystilbene B, hypargystilbene D, and hypargystilbene E exhibited protein tyrosine phosphatase 1B inhibitory effects with corresponding IC50 values of 3.23, 37.31, and 2.53 nM.
a Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu 610041 , China.
Pu-Zhao
PZ
Zhang
Jian
J
Gu
Guo-Lin
GL
Zhang
D031622:Artocarpus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D013267:Stilbenes; C000598439:hypargystilbene B; C000598440:hypargystilbene D; C000598441:hypargystilbene E; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1
Artocarpus nanchuanensis; PTP1B; hypargystilbene; stilbene