Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated.
Emerging studies link vascular risk factors and cerebrovascular health to the prevalence and rates of progression in Alzheimer's disease (AD). The brain's ability to maintain constant blood flow across a range of cerebral perfusion pressures, or autoregulation, may both promote and result from small vessel cerebrovascular disease and AD-related amyloid pathology. Here, we examined the relationship among cerebral autoregulation, small vessel cerebrovascular disease, and amyloid deposition in 14 non-demented older adults. Reduced cerebral autoregulation, was associated with increased amyloid deposition and increased white matter hyperintensity volume, which, in turn were positively associated with each other. For the first time in humans, we demonstrate an interrelationship among AD pathology, small vessel cerebrovascular disease, and cerebral autoregulation. Vascular factors and AD pathology are not independent but rather appear to interact.
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA. Electronic address: amb2139@columbia.edu.
Adam M
AM
Brickman
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA.
Vanessa A
VA
Guzman
Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Miguel
M
Gonzalez-Castellon
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Qolamreza
Q
Razlighi
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Yian
Y
Gu
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA.
Atul
A
Narkhede
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Sarah
S
Janicki
Department of Radiology, College of Physicians and Surgeons, Columbia University, USA.
Masanori
M
Ichise
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Yaakov
Y
Stern
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Jennifer J
JJ
Manly
Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, USA; G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, USA.
Nicole
N
Schupf
Department of Neurology, College of Physicians and Surgeons, Columbia University, USA.
Randolph S
RS
Marshall
D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D066127:White Matter / Q000473:pathology*
D000682:Amyloid
Alzheimer; Amyloid; Cerebral autoregulation; White matter hyperintensities; ’s disease