Synthesis and antibacterial activities of Yanglingmycin analogues.
The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 µg/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.
College of Sciences, Northwest A & F University; Yangling, Shaanxi Province 712100, P. R. China; Shaanxi Province Key Laboratory of Research and Development of Botanic Pesticide, Yangling, Shaanxi Province, China.
Long-Bo
LB
Li
Wen-Jia
WJ
Dan
Fang-Fang
FF
Tan
Li-Hui
LH
Cui
Zhi-Peng
ZP
Yuan
Wen-Jun
WJ
Wu
Ji-Wen
JW
Zhang
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D044224:Pseudomonas syringae / Q000187:drug effects; D043368:Ralstonia solanacearum / Q000187:drug effects; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D010080:Oxazoles; C000602973:yanglingmycin