Immune reactions and nerve repair in mice with sciatic nerve injury 14 days after intraperitoneal injection of Brazil.
BALB/c mice were intraperitoneally injected with 10, 5 or 2.5 mg/kg Brazil for 14 days after sciatic nerve injury. Results demonstrate that the spleen T/B lymphocyte stimulation index and serum circulating immune complex concentration were significantly reduced, and the morphology of the soleus muscle was restored in mice with sciatic nerve injury. These effects of Brazil were dose-dependent. Our experimental findings indicate that Brazil can regulate immune responses after nerve injury and promote sciatic nerve repair.
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China.
Jian
J
Cao
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China.
Zhongping
Z
Niu
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China.
Yongan
Y
Wang
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China.
Yiwen
Y
Jiang
Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Haoyu
H
Liu
Second Department of Orthopedics, Chifeng Municipal Hospital, Chifeng 024000, Inner Mongolia Autonomous Region, China.
Binfeng
B
Wang
Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Weitian
W
Yin
Department of Hand Surgery, China-Japanese Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Lisen
L
Li
Brazil; immune; neural regeneration; peripheral nerve injury; repair