Association Between PTPN22 Polymorphisms and IgE Responses to Staphylococcal Superantigens in Chronic Urticaria.
Protein tyrosine phosphatase-22 (PTPN22) gene encodes lymphoid-specific tyrosine phosphatase (Lyp), an inhibitor of T cell activation. A polymorphism of the PTPN22 gene has been found to be associated with chronic urticaria (CU). We investigated the associations between PTPN22 gene polymorphisms and CU characteristics, including serum specific IgE antibodies response to toxic shock syndrome toxin-1 (TSST-1) and staphylococcal enterotoxin A (SEA). CU patients (n=409) and normal healthy controls (n=388) were enrolled in the present study. Serum specific IgE to TSST-1 and SEA were measured by ImmunoCAP®. Five PTPN22 single nucleotide polymorphisms, -1123G>C, 1858C>T, 13145A>G, 14943C>T, and 20628A>G, were genotyped. There were no significant differences in genotype or haplotype frequencies of these polymorphisms between the 2 groups. CU patients carrying the GG genotype at 20628A>G (P=0.035) or haplotype 3 [GGG] (P=0.047) had a significantly higher prevalence of serum specific IgE to TSST-1 compared to non-carriers. Similarly, CT/TT genotype at 14943C>T had a significantly higher prevalence of serum specific IgE to SEA (P=0.045). The findings suggest that the PTPN22 gene polymorphisms at 20628A>G and 14943C>T may enhance serum specific IgE responses to TSST-1 and SEA, which may contribute to CU pathogenesis.
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Sailesh
S
Palikhe
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Seung Hyun
SH
Kim
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
Le Duy
le D
Pham
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.
Young Min
YM
Ye
Department of Biomedical Sciences, Ajou University School of Medicine, Suwon, Korea.; Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr.
Hae Sim
http://orcid.org/0000-0003-2614-0303
HS
Park
Chronic urticaria; PTPN225; polymorphisms; staphylococcal enterotoxin