[Stage IV small cell esophageal carcinoma that responded to various chemotherapeutic regimens with relative longevity - a case report].
Small cell carcinoma of the esophagus is reported to be both rare and aggressive, and is commonly associated with a short post-diagnosis survival period. We report a case of Stage IV small cell carcinoma of the esophagus involving a relatively long survival period of 2 years. The patient was a 70-year-old man with a chief complaint of epigastric discomfort. Upper gastrointestinal endoscopy by a local physician showed a protruding tumor at the mid-thoracic esophagus. Tumor biopsy revealed small cell carcinoma. Chest-abdominal computed tomography revealed multiple liver metastases, and swelling of a number of regional lymph nodes. The diagnosis was cT3N4M1, cStage IVb esophageal small cell carcinoma. According to the regimen used for lung small cell carcinoma, we administered CDDP/CPT-11. After administration of four courses, the primary lesion, liver metastases, and lymph node metastases significantly reduced, indicating a partial response. However, after completion of eight courses, liver metastasis and lymph node swelling recurred. The patient subsequently received other therapeutic regimens such as CBDCA/VP-16, AMR, NGT, and CDGP/5-FU. However, the tumor gradually progressed, and the patient died approximately 2 years after the first treatment.
Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.
Yoshihito
Y
Yamakoshi
Naoshi
N
Kubo
Masaichi
M
Ohira
Katsunobu
K
Sakurai
Takahiro
T
Toyokawa
Masatsune
M
Shibutani
Sadaaki
S
Yamazoe
Hisashi
H
Nagahara
Kenjiro
K
Kimura
Ryosuke
R
Amano
Hiroaki
H
Tanaka
Kazuya
K
Muguruma
Hiroshi
H
Ohtani
Masakazu
M
Yashiro
Kiyoshi
K
Maeda
Kosei
K
Hirakawa
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed