The contributions of breast density and common genetic variation to breast cancer risk.
We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. We incorporated the PRS odds ratio (OR) into the Breast Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable risk and compared five-year absolute risk predictions between models using area under the curve (AUC) statistics. All statistical tests were two-sided. BI-RADS density and PRS were independent risk factors across all three studies (P interaction = .23). Relative to those with scattered fibroglandular densities and average PRS (2(nd) quartile), women with extreme density and highest quartile PRS had 2.7-fold (95% confidence interval [CI] = 1.74 to 4.12) increased risk, while those with low density and PRS had reduced risk (OR = 0.30, 95% CI = 0.18 to 0.51). PRS added independent information (P < .001) to the BCSC model and improved discriminatory accuracy from AUC = 0.66 to AUC = 0.69. Although the BCSC-PRS model was well calibrated in case-control data, independent cohort data are needed to test calibration in the general population.
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF). vachon.celine@mayo.edu.
Celine M
CM
Vachon
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
V Shane
VS
Pankratz
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Christopher G
CG
Scott
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Lothar
L
Haeberle
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Elad
E
Ziv
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Matthew R
MR
Jensen
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Kathleen R
KR
Brandt
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Dana H
DH
Whaley
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Janet E
JE
Olson
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Katharina
K
Heusinger
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Carolin C
CC
Hack
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Sebastian M
SM
Jud
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Matthias W
MW
Beckmann
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Ruediger
R
Schulz-Wendtland
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Jeffrey A
JA
Tice
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Aaron D
AD
Norman
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Julie M
JM
Cunningham
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Kristen S
KS
Purrington
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Douglas F
DF
Easton
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Thomas A
TA
Sellers
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Karla
K
Kerlikowske
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Peter A
PA
Fasching
Affiliations of authors: Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic (CMV, VSP, CGS, MRJ, JEO, ADN, FJC); Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany (LH, KH, CCH, SMJ, MWB, PAF); Department of Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA (EZ); Departments of Medicine and Epidemiology and Biostatistics and General Internal Medicine Section, Department of Veterans Affairs and Division of General Internal Medicine (EZ, JAT, KK); Division of Breast Imaging, Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN (KRB, DHW); Institute of Diagnostic Radiology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany (RS-W); Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN (JMC, FJC); Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI (KSP); University of Cambridge, Centre for Cancer Genetic Epidemiology, Cambridge, UK (DFE); Moffitt Cancer Center, Tampa, Florida (TAS); University of California at Los Angeles, Department of Medicine, Division Hematology/Oncology, David Geffen School of Medicine, Los Angeles, CA (PAF).
Fergus J
FJ
Couch
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001940:Breast / Q000473:pathology*; D000071060:Breast Density; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D042361:Mammary Glands, Human / Q000002:abnormalities; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011859:Radiography; D018570:Risk Assessment; D012307:Risk Factors; D014481:United States / Q000453:epidemiology