A Review and Proposed Approach to the Neutrophilic Dermatoses of Childhood.
Neutrophilic dermatoses (NDs) are inflammatory skin conditions that are not associated with infection. The classification and clinical approach to these conditions in children is poorly described. This review classifies these conditions into five nosological subtypes: Sweet's syndrome, pyoderma gangrenosum, aseptic pustules, neutrophilic urticarial dermatoses, and Marshall's syndrome. In addition, we review the various secondary diseases that need to be excluded in the clinical management of the NDs of childhood, with a focus on the autoinflammatory conditions that the reader may not be familiar with. We propose a practical clinical approach to these disorders.
Department of Rheumatology, University of Cape Town, Cape Town, South Africa.|Department of Dermatology, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
Kate
K
Webb
Department of Rheumatology, University of Cape Town, Cape Town, South Africa.|Department of Dermatology, School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa.
Carol
C
Hlela
Division of Dermatology, Department of Medicine, Faculty of Medicine and Health Sciences, University of Stellenbosch, Stellenbosch, South Africa.
H Francois
HF
Jordaan
South African TB Vaccine Initiative, University of Cape Town, Cape Town, South Africa.
Sara
S
Suliman
South African TB Vaccine Initiative, University of Cape Town, Cape Town, South Africa.
Thomas
T
Scriba
Faculté de Médecine, Université de Strasbourg and Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Dan
D
Lipsker
Department of Rheumatology, University of Cape Town, Cape Town, South Africa.
Chris
C
Scott
D000038:Abscess / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D002386:Cataract / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D024161:Collagen Type XI / Q000145:classification / Q000172:deficiency; D019465:Craniofacial Abnormalities / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D006319:Hearing Loss, Sensorineural / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D020556:Neutrophil Infiltration; D010009:Osteochondrodysplasias / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D017511:Pyoderma Gangrenosum / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D012871:Skin Diseases / Q000145:classification* / Q000175:diagnosis / Q000188:drug therapy; D016463:Sweet Syndrome / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy; D014581:Urticaria / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy
D024161:Collagen Type XI