Asymmetric Suzuki-Miyaura cross-coupling for the synthesis of chiral biaryl compounds as potential monophosphine ligands.
Efficient asymmetric Suzuki-Miyaura coupling reactions have been employed for the first time to synthesize chiral biaryl compounds with phosphinate groups as chiral auxiliaries. A series of functionalized chiral biaryls are thereby synthesized in excellent yields and good diastereoselectivities (up to >95:5 d.r.) and axially chiral monophosphorus ligands are obtained through further functionalizations.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 73000 (P.R. China).
Yan-Na
YN
Ma
Shang-Dong
SD
Yang
asymmetric synthesis; biaryl compounds; cross-coupling; ligand design; phosphanes