Comparative analyses of lysophosphatidic acid receptor-mediated signaling.
Lysophosphatidic acid (LPA) is a bioactive lipid mediator that activates G protein-coupled LPA receptors to exert fundamental cellular functions. Six LPA receptor genes have been identified in vertebrates and are classified into two subfamilies, the endothelial differentiation genes (edg) and the non-edg family. Studies using genetically engineered mice, frogs, and zebrafish have demonstrated that LPA receptor-mediated signaling has biological, developmental, and pathophysiological functions. Computational analyses have also identified several amino acids (aa) critical for LPA recognition by human LPA receptors. This review focuses on the evolutionary aspects of LPA receptor-mediated signaling by comparing the aa sequences of vertebrate LPA receptors and LPA-producing enzymes; it also summarizes the LPA receptor-dependent effects commonly observed in mouse, frog, and fish.
Division of Molecular Neurobiology, Department of Life Science, Kinki University, Higashiosaka, 577-8502, Japan, nfukushima@life.kindai.ac.jp.
Nobuyuki
N
Fukushima
Shoichi
S
Ishii
Toshifumi
T
Tsujiuchi
Nao
N
Kagawa
Kazutaka
K
Katoh
D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D049368:Receptors, Lysophosphatidic Acid / Q000145:classification / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D008246:Lysophospholipids; D049368:Receptors, Lysophosphatidic Acid; C032881:lysophosphatidic acid