Low-intensity late gadolinium enhancement predominates in hypertrophic cardiomyopathy.
OBJECTIVE
Assess the extent of low- versus high-intensity late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM).


METHODS
Low- versus high-intensity LGE indexed volumes in 19 HCM patients were compared to 23 myocardial infarction (MI) patients.


RESULTS
Total, low-, and high-intensity LGE volumes in HCM vs. MI were 7.6ml/m(2), 4.7, and 2.4 vs. 11.2, 2.5, and 7.1, respectively. Total LGE volume did not differ (P=.13), though low- and high-intensity did (P=.05, .004). 67% versus 26% of all LGE was low-intensity in HCM versus MI (P<.001).


CONCLUSIONS
LGE in HCM is predominantly low-intensity, so a low threshold may be the most appropriate.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628. Electronic address: david.naeger@ucsf.edu.
David M
DM
Naeger
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
Charles
C
Higgins
Department of Medicine, Division of Cardiology, University of California, San Francisco, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
Teresa
T
De Marco
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
Stefano
S
Muzzarelli
Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave., M-391, San Francisco, CA 94143-0628.
Karen G
KG
Ordovas
D000293:Adolescent; D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D012307:Risk Factors; D055815:Young Adult
D003287:Contrast Media; D005682:Gadolinium
DCE; HCM; Hypertrophic cardiomyopathy; LGE; Late gadolinium enhancement