Application of response surface methodology in optimization of electrospinning process to fabricate (ferrofluid/polyvinyl alcohol) magnetic nanofibers.
Magnetic nanofibers are composed of good dispersion of magnetic nanoparticles along an organic material. Magnetic nanofibers are potentially useful for composite reinforcement, bio-medical and tissue engineering. Nanofibers with the thinner diameter have to result in higher rigidity and tensile strength due to better alignments of lamellae along the fiber axis. In this study, the performance of electrospinning process was explained using response surface methodology (RSM) during fabrication of magnetic nanofibers using polyvinyl alcohol (PVA) as a shelter for (γ-Fe2O3) nanoparticles where the parameters investigated were flow rate, applied voltage, distance between needle and collector and collector rotating speed. The response variable was diameter distribution. The two parameters flow rate and applied voltage in primary evaluation were distinguished as significant factors. Central composite design was applied to optimize the variable of diameter distribution. Quadratic estimated model developed for diameter distribution indicated the optimum conditions to be flow rate of 0.25 ml/h at voltage of 45 kV while the distance and rotating speed are at 8 cm and 1500 rps respectively. The obtained model was verified successfully by the confirmation experiments.
Department of Materials, Manufacturing & Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310, UTM, Johor Bahru, Johor, Malaysia.
Mohaddeseh
M
Ahmadipourroudposht
Department of Materials, Manufacturing & Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310, UTM, Johor Bahru, Johor, Malaysia. Electronic address: faehsan2@live.utm.my.
Ehsan
E
Fallahiarezoudar
Department of Materials, Manufacturing & Industrial Engineering, Faculty of Mechanical Engineering, Universiti Teknologi Malaysia, 81310, UTM, Johor Bahru, Johor, Malaysia.
Noordin Mohd
NM
Yusof
Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, 81310, UTM, Johor Bahru, Johor, Malaysia.
Ani
A
Idris
D000704:Analysis of Variance; D005290:Ferric Compounds / Q000737:chemistry*; D060328:Magnetic Phenomena; D008962:Models, Theoretical; D057139:Nanofibers / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011336:Probability; D023822:Tissue Engineering / Q000379:methods*
D005290:Ferric Compounds; C000499:ferric oxide; D011142:Polyvinyl Alcohol
Central composite design; Diameter distribution; Electrospinning; Magnetic nanofibers; Response surface methodology; Tissue engineering