[Radiosensitizing effect of 5-aminolevulinic acid (5-ALA ) in Colon cancer].
5-aminolevulinic acid (5-ALA) is widely used in clinical practice because it shows tumor-selective accumulation of protoporphyrin IX, a fluorescent substance and a metabolite of 5-ALA. In addition, some studies have reported that 5-ALA increases the radiation sensitivity of glioma and melanoma. In this study, we investigated the radiosensitization effect of 5-ALA on colon cancer. Mice implanted with the human colon cancer cell line HT29 were administered 5-ALA and subsequently X-ray irradiated. These mice were compared with those not administered 5-ALA. Following multiple irradiations, the tumor volume of the 5-ALA group was significantly lower than that of the non-5-ALA group (day 5: p value=0.0489, day 8: p value= 0.0318, day 12: p value=0.0394). Tumor growth was inhibited by multiple irradiations in the 5-ALA group compared with the non-5-ALA group. These results suggest that 5-ALA also exhibits a radiosensitization effect on colon cancer.
Dept. of Surgery, Division of Digestive Surgery, Kyoto Prefectural University of Medicine.
Yosuke
Y
Kamada
Yasutoshi
Y
Murayama
Kyoichi
K
Harada
Masumi
M
Nishimura
Yutaka
Y
Kondo
Hirotaka
H
Konishi
Ryo
R
Morimura
Shuhei
S
Komatsu
Atsushi
A
Shiozaki
Yoshiaki
Y
Kuriu
Hisashi
H
Ikoma
Masayoshi
M
Nakanishi
Daisuke
D
Ichikawa
Hitoshi
H
Fujiwara
Kazuma
K
Okamoto
Chouhei
C
Sakakura
Eigo
E
Otsuji
D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D000818:Animals; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D023041:Xenograft Model Antitumor Assays
D011838:Radiation-Sensitizing Agents; D000622:Aminolevulinic Acid