[Oncology-related issues of angiotensin-receptor blockers].
Recently controversial data emerged regarding the cancer inducing activity of angiotensin-receptor blockers. There may be several reasons which may explain the controversial data published in the scientific literature including wrong trial design or misinterpretation of data. Considering the large number of patients receiving treatment for hypertension, it is essential to have a clear view of the cancer-related safety of these drugs. This paper tries to give an overview on this issue based on data available in the literature. According to our present knowledge, angiotensin-receptor blockers exert more likely anticancer activity rather than carcinogenesis inducing effect. In fact, some oncologic trials point to this direction, because angiotensin-receptor blockers are suggested as co-treatment to chemotherapy in cases of pancreatic, oesophageal and gastric cancers.
Bajcsy-Zsilinszky Kórház Onkológiai Osztály Budapest Maglódi út 89-91. 1106.
András
A
Telekes
Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika, Geriátriai Tanszéki Csoport Budapest Szent Imre Egyetemi Oktatókórház Nephrologia-Hypertonia Profil és Aktív Geriátriai Részleg Budapest B. Braun Avitum Zrt. Dialízis Hálózat 1. Sz. Dialízisközpont Budapest.
István
I
Kiss
D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002273:Carcinogens / Q000494:pharmacology*; D003928:Diabetic Nephropathies / Q000188:drug therapy; D017277:Drug Approval; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D009203:Myocardial Infarction / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D012084:Renin-Angiotensin System / Q000187:drug effects; D020521:Stroke / Q000517:prevention & control
D047228:Angiotensin II Type 1 Receptor Blockers; D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D002273:Carcinogens
angiotensin-receptor blockers; angiotenzinreceptor-blokkolók; anticancer activity; carcinogenesis; rákkeltő hatás; tumorellenes hatás