Attenuation of inflammatory responses by hydrogen sulfide (H₂S) in ischemia/reperfusion injury.
Cellular and tissue injury induced by ischemia is often exacerbated by restoring perfusion to the affected organ system. The injury, termed ischemia-reperfusion injury, is mediated in large part by the inflammatory response generated in the setting of reperfusion. Recent research has demonstrated that the administration of hydrogen sulfide as a therapeutic agent in the setting of ischemia-reperfusion can markedly attenuate the inflammatory response with subsequent mitigation of tissue injury and improved function. This beneficial anti-inflammatory effect has been observed in multiple organ systems, subject to ischemia-reperfusion injury, the details of which are the subject of this chapter.
Division of Cardiothoracic Surgery, Department of Surgery, Alpert Medical School of Brown University, Providence, Rhode Island.
Neel R
NR
Sodha
Division of Cardiothoracic Surgery, Department of Surgery, Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: fsellke@lifespan.org.
Frank W
FW
Sellke
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000096:biosynthesis; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051036:Large-Conductance Calcium-Activated Potassium Channels / Q000378:metabolism; D051379:Mice; D051381:Rats; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013552:Swine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D051036:Large-Conductance Calcium-Activated Potassium Channels; D006862:Hydrogen Sulfide
Hydrogen sulfide; Inflammation; Ischemia; Ischemia–reperfusion injury; Reperfusion