Assessment of an innovative antimicrobial surface disinfectant in the operating room environment using adenosine triphosphate bioluminescence assay.
Terminal cleaning in the operating room is a critical step in preventing the transmission of health care-associated pathogens. The persistent disinfectant activity of a novel isopropyl alcohol/organofunctional silane solution (ISO) was evaluated in 4 operating rooms after terminal cleaning. Adenosine triphosphate bioluminescence documented a significant difference (P < .048) in surface bioburden on IOS-treated surfaces versus controls. RODAC plate cultures revealed a significant (P < .001) reduction in microbial contamination on IOS-treated surfaces compared with controls. Further studies are warranted to validate the persistent disinfectant activity of ISO within selective health care settings.
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Brian D
BD
Lewis
Infection Prevention Consultants, Boston, MA.
Maureen
M
Spencer
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Peter J
PJ
Rossi
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Cheong J
CJ
Lee
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Kellie R
KR
Brown
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Michael
M
Malinowski
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI.
Gary R
GR
Seabrook
Department of Surgery (Division of Vascular Surgery), Medical College of Wisconsin, Milwaukee, WI; Surgical Microbiology Research Laboratory, Medical College of Wisconsin, Milwaukee, WI. Electronic address: edmiston@mcw.edu.
Charles E
CE
Edmiston
D019840:2-Propanol / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000032:analysis; D004202:Disinfectants / Q000494:pharmacology*; D004783:Environmental Microbiology; D006302:Health Services Research; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008163:Luminescent Measurements / Q000379:methods; D009873:Operating Rooms; D012821:Silanes / Q000494:pharmacology
D004202:Disinfectants; D012821:Silanes; D000255:Adenosine Triphosphate; D019840:2-Propanol
Adenosine triphosphate bioluminescence assay; Isopropyl alcohol/organofunctional silane solution; Operating room; RODAC plate counts; Terminal cleaning