Cerium fluoride nanoparticles protect cells against oxidative stress.
A novel facile method of non-doped and fluorescent terbium-doped cerium fluoride stable aqueous sols synthesis is proposed. Intense green luminescence of CeF3:Tb nanoparticles can be used to visualize these nanoparticles' accumulation in cells using confocal laser scanning microscopy. Cerium fluoride nanoparticles are shown for the first time to protect both organic molecules and living cells from the oxidative action of hydrogen peroxide. Both non-doped and terbium-doped CeF3 nanoparticles are shown to provide noteworthy protection to cells against the vesicular stomatitis virus.
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
Alexander B
AB
Shcherbakov
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv D0368, Ukraine.
Nadezhda M
NM
Zholobak
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia.
Alexander E
AE
Baranchikov
Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow 115409, Russia.
Anastasia V
AV
Ryabova
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119991, Russia; National Research Tomsk State University, Tomsk 634050, Russia. Electronic address: van@igic.ras.ru.
Vladimir K
VK
Ivanov
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002563:Cerium / Q000494:pharmacology* / Q000633:toxicity; D004396:Coloring Agents / Q000737:chemistry; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects*; D005459:Fluorides / Q000494:pharmacology* / Q000633:toxicity; D006861:Hydrogen Peroxide / Q000378:metabolism; D007700:Kinetics; D049449:Luminescence; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010316:Particle Size; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D034421:Sus scrofa; D013725:Terbium / Q000737:chemistry; D018116:Vesiculovirus / Q000187:drug effects
D000998:Antiviral Agents; D004396:Coloring Agents; D013725:Terbium; C058441:cerium fluoride; D002563:Cerium; D006861:Hydrogen Peroxide; D005459:Fluorides
Cerium fluoride nanoparticles; Living cells; Luminescence; Oxidative stress; Terbium doped CeF(3); Toxicity; Virus