Corneal biomechanical properties in floppy eyelid syndrome.
OBJECTIVE
To determine corneal biomechanical properties in patients with floppy eyelid syndrome (FES) and to compare them with eyes of controls.


METHODS
This case-control study included 208 eyes (72 eyes with FES and 136 without FES) of 107 patients (37 patients with FES and 70 without FES). Patients underwent a complete clinical eye examination that included corneal biomechanical evaluation carried out with the Reichert Ocular Response Analyzer.


RESULTS
Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc) were evaluated. Mean CH was significantly lower in patients with FES than in those without FES (9.51 ± 1.56 vs. 11.66 ± 9.11; P < 0.001). These results remained statistically significant after adjusting for age and apnea-hypoapnea index (AHI) (P = 0.028). Mean CRF was 10.02 ± 2.08 in the group of patients with FES and 11.21 ± 5.36 in the group of patients without FES (P = 0.001). Mean IOPcc was 17.7 ± 4.8 in patients with FES and 16.3 ± 4.4 in those without FES (P = 0.036). After adjusting for age and AHI, these differences in CRF and IOPcc were not statistically significant (P = 0.26 and P = 0.87, respectively). No statistically significant difference was found between patients with and without FES for Goldmann-correlated intraocular pressure or CCT.


CONCLUSIONS
Patients with FES had statistically lower CH values. Our findings suggest that corneal biomechanical properties could be changed in patients with FES, reflecting additional structural changes in FES.
MaJesús
M
Muniesa
*Ophthalmology Department, Arnau de Vilanova Universitary Hospital, IRB Lleida, Lleida, Catalonia, Spain; †Respiratory Department, Arnau de Vilanova-Santa María Universitary Hospital, IRB Lleida, Lleida, Catalonia, Spain; and ‡Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Madrid, Spain.
MaJesús
M
Muniesa Royo
Ana
A
March
Ana
A
March de Ribot
Manuel
M
Sánchez-de-la-Torre
Valetín
V
Huerva
Valetín
V
Huerva Escanilla
Carmen
C
Jurjo
Carmen
C
Jurjo Campo
Ferran
F
Barbé
Ferran
F
Barbé Illa
D000368:Aged; D001696:Biomechanical Phenomena; D016022:Case-Control Studies; D003315:Cornea / Q000502:physiology*; D004548:Elasticity / Q000502:physiology*; D005141:Eyelid Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000503:physiopathology*; D014065:Tonometry, Ocular