[Acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA].
OBJECTIVE
We report the first case of acute encephalopathy induced by vaccination in an infant with methylmalonic aciduria cblA in China.


METHODS
The clinical presentation, blood acylcarnitines analysis, urine organic acids analysis and gene studies of the patient were summarized.


RESULTS
The proband, a boy, was admitted at the age of 15 months because of recurrent vomiting, acidosis and development delay for 8 months. The previously healthy boy presented vomiting and coma just one hour after hepatitis B vaccination at the age of seven months. Moderate dehydration, electrolyte disturbance and metabolic acidosis had been found. Although his acute metabolic crisis had been corrected soon after intravenous transfusion, psychomotor retardation and recurrent vomiting had been observed. When he was 15 months old, vomiting and lethargy occurred again 3 hours after DTaP vaccination. He was weakened as the illness became worse and got coma with dyspnea 7 days later. He was hospitalized with the suspected diagnosis of viral encephalitis. Blood acylcarnitines analysis, urine organic acids analysis and gene study had been performed for the etiologic investigation.His blood propionylcarnitine (16.3 µmol/L vs. normal range 1.0-5.0 µmol/L) and propionylcarnitine/free carnitine ratio (0.27 vs. normal range 0.03 to 0.25) increased. Markedly elevated urinary methylmalonic acid (388.21 mmol/mol creatinine vs. normal range 0.2 to 3.6 mmol/mol creatinine) and normal plasma total homocysteine supported the diagnosis of isolated methylmalonic aciduria. Two mutations, c.650 T>A (p.L217X) and c.742 C>T (p.Q248X), were identified in his MMAA gene, confirmed the diagnosis of cblA. Each parent carried one of the two mutations. Progressive clinical and biochemical improvement has been observed after hydroxylcobalamin injection, protein-restricted diet with the supplements of special formula and L-carnitine. He is currently 2 years and 7 months old with normal development and general condition.


CONCLUSIONS
A boy with cblA was firstly detected after the acute encephalopathy induced by vaccination in China. It is important to pay more attention to the patients with metabolic crisis or organ damage after vaccination. Metabolic studies are keys to the diagnosis of potential diseases and improve the outcome.
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Yupeng
Y
Liu
Tongfei
T
Wu
Haijun
H
Wang
Yuan
Y
Ding
Jinqing
J
Song
Xiyuan
X
Li
Yao
Y
Zhang
Qiao
Q
Wang
Email: organic.acid@126.com.
Yanling
Y
Yang
D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications*; D001927:Brain Diseases / Q000139:chemically induced*; D002331:Carnitine / Q000031:analogs & derivatives; D018753:Diet, Protein-Restricted; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D008297:Male; D008764:Methylmalonic Acid / Q000652:urine; D009154:Mutation; D014611:Vaccination / Q000009:adverse effects*; D014803:Vitamin B Complex; D014839:Vomiting
D017325:Hepatitis B Vaccines; C116917:acylcarnitine; D014803:Vitamin B Complex; C003223:propionylcarnitine; D008764:Methylmalonic Acid; D002331:Carnitine