Sensory TRP channels: the key transducers of nociception and pain.
Peripheral detection of nociceptive and painful stimuli by sensory neurons involves a complex repertoire of molecular detectors and/or transducers on distinct subsets of nerve fibers. The majority of such molecular detectors/transducers belong to the transient receptor potential (TRP) family of cation channels, which comprise both specific receptors for distinct nociceptive stimuli, as well as for multiple stimuli. This chapter discusses the classification, distribution, and functional properties of individual TRP channel types that have been implicated in various nociceptive and/or painful conditions.
Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Aaron D
AD
Mickle
Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrew J
AJ
Shepherd
Department of Pharmacology, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesia, The University of Iowa Roy J. and Lucile A. Carver College of Medicine, Iowa City, Iowa, USA; Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: mohapatrad@anest.wustl.edu.
Durga P
DP
Mohapatra
D000818:Animals; D006801:Humans; D008954:Models, Biological; D059225:Nociception; D010146:Pain / Q000378:metabolism*; D012679:Sense Organs / Q000378:metabolism*; D015398:Signal Transduction; D050051:Transient Receptor Potential Channels / Q000378:metabolism*
D050051:Transient Receptor Potential Channels
Nociception; Pain; TRP channel; TRPA1; TRPM3; TRPM8; TRPV1; TRPV2; TRPV3; TRPV4