[EEG-correlates of frontal dysfunction as predictors of relative pharmacoresistance in treatment of endogenous affective disorders].
OBJECTIVE
To analyze background EEG parameters correlated with frontal lobe dysfunction, that might be considered, prospectively, as individual predictors of relative pharmacoresistance (or relatively lower treatment efficacy) in different forms of endogenous affective disorders.


METHODS
An analysis of a set of several EEG parameters and quantitative clinical assessments has been carried out during the treatment in patients with endogenous depression (group 1), depressive-delusional conditions in the frames of attack-like schizophrenia (group 2), and manic-delusional conditions in the frames of attack-like schizophrenia (group 3).


CONCLUSIONS
Statistically significant correlations have been revealed between initial (before treatment course) values of narrow-band EEG spectral power (mainly of beta activity reflected the frontal lobe dysfunction and hyper-activation of brain stem structures) and quantitative clinical assessments of patient's conditions at remission stage. The data obtained allow to justify the basic considerations on the brain mechanisms of different affective disorders, and to reveal possible neurophysiologic predictors of relative pharmacoresistance (or relatively lower treatment efficacy) in patients with endogenous affective disorders.
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
A F
AF
Iznak
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
E V
EV
Iznak
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
I V
IV
Oleĭchik
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
L I
LI
Abramova
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
S A
SA
Sorokin
FGBU 'Nauchnyĭ tsentr psikhicheskogo zdorov'ia' RAMN, Moskva.
S A
SA
Stoliarov
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D004351:Drug Resistance; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012720:Severity of Illness Index; D055815:Young Adult