A case of solitary fibrous tumor arising from the palatine tonsil.
Solitary fibrous tumor (SFT) is a distinctive, relatively uncommon soft-tissue neoplasm that usually arises from the pleura. It occurs at various sites; head and neck lesions are very rare. While most of these tumors have a benign course, a small number have malignant potential. We describe a rare case of SFT arising from the left palatine tonsil in a 66-year-old Japanese woman. The mass was completely resected. Immunohistochemical studies were strongly positive for CD34 and bcl-2, mildly positive for phosphorylated protein kinase B and phosphorylated extracellular signal-regulated kinase 1/2, and negative for platelet-derived growth factor receptor alpha and p53. These findings suggested that this tumor was benign. The patient showed no evidence of recurrence during 2 years of follow-up. We believe that the candidate prognostic marker should be checked to distinguish malignant from benign SFTs.
Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University, Saitama Medical Center, 857-1 Amanuma, Omiya, Saitama City, Saitama, 330-8503 Japan. kanatake@omiya.jichi.ac.jp.
Takeharu
T
Kanazawa
Kozue
K
Kodama
Mitsuhiro
M
Nokubi
Kazuo
K
Gotsu
Akihiro
A
Shinnabe
Masayo
M
Hasegawa
Gen
G
Kusaka
Yukiko
Y
Iino
D018952:Antigens, CD34 / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D014066:Palatine Tonsil / Q000473:pathology* / Q000601:surgery; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D054364:Solitary Fibrous Tumors / Q000473:pathology* / Q000601:surgery; D014067:Tonsillar Neoplasms / Q000473:pathology* / Q000601:surgery
D018952:Antigens, CD34; C481505:BCL2L15 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2