Acaricidal effects of fluazuron (2.5 mg/kg) and a combination of fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), administered at different routes, against Rhipicephalus (Boophilus) microplus parasitizing cattle.
The present study aimed to evaluate the acaricidal efficacy of fluazuron (2.5 mg/kg), administered as a pour-on, in comparison to an injectable formulation containing fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), against Rhipicephalus (Boophilus) microplus in naturally and experimentally infested cattle. Two studies were conducted with different tick strains, one with artificial infestations (Stall Test, using leight animals per group) and one with natural infestations (utilizing ten animals per group). In both studies, the animals were randomized, according to average tick counts performed on days -3, -2 and -1, into four groups: T01, negative control (saline solution); T02, pour-on fluazuron (2.5 mg/kg); T03: subcutaneous fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg); and T04 subcutaneous ivermectin (0.63 mg/kg). Based on obtained results, and considering the utilized tick strains, it was possible to conclude that the pour-on fluazuron (2.5 mg/kg) formulation demonstrated high acaricidal efficacy, with protection periods ranging from 49 to 77 days against Rhipicephalus (Boophilus) microplus. On the other hand, for the injectable fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg) formulation, it was not possible to observe elevated anti-R. (B.) microplus effect on both artificial and experimental infestation studies. Results observed for this combination were similar or inferior to those obtained by subcutaneous ivermectin (0.63 mg/kg). Future studies with this formulation containing fluazuron (1.6 mg/kg) + ivermectin (0.63 mg/kg), regarding pharmacokinetic and/or bioavailability profiles, or even studies analyzing both this active principles separately, are needed, seeking to better understand the effects of such combination against Rhipicephalus (Boophilus) microplus parasitizing cattle.
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Lucas Vinicius Costa
LV
Gomes
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil; Universidade Federal de Goiás (UFG), Regional de Jataí, BR-364 Km 192, Parque Industrial, Jataí, GO 75801-615, Brasil. Electronic address: wdzlopes@hotmail.com.
Welber Daniel Zanetti
WD
Lopes
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Breno Cayeiro
BC
Cruz
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Weslen Fabricio
WF
Teixeira
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Gustavo
G
Felippelli
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Willian G
WG
Maciel
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Murilo Abud
MA
Bichuette
Universidade Estadual de Maringá (UEM), Campus Regional de Umuarama, Rodov. PR 489, n° 1.400.
Maycon A
MA
Ruivo
Universidade Estadual de Maringá (UEM), Campus Regional de Umuarama, Rodov. PR 489, n° 1.400.
Marcos Henrique
MH
Alcantara Colli
Universidade Estadual de Maringá (UEM), Campus Regional de Umuarama, Rodov. PR 489, n° 1.400.
Rafael Silveira
RS
Carvalho
Universidade Estadual de Maringá (UEM), Campus Regional de Umuarama, Rodov. PR 489, n° 1.400.
Antonio Campanha
AC
Martinez
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil; Universidade Camilo Castelo Branco (Unicastelo), Av. Hilário da Silva Passo 950, Descalvado, SP 13690-970, Brasil.
Vando Edésio
VE
Soares
Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani, s/n CEP:14884-900, Jaboticabal, São Paulo-Brazil.
Alvimar José
AJ
da Costa
D056810:Acaricides / Q000008:administration & dosage*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D004333:Drug Administration Routes / Q000662:veterinary*; D004358:Drug Therapy / Q000379:methods*; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage*; D008297:Male; D010671:Phenylurea Compounds / Q000008:administration & dosage*; D048494:Rhipicephalus / Q000187:drug effects* / Q000502:physiology; D013984:Tick Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
D056810:Acaricides; D010671:Phenylurea Compounds; D007559:Ivermectin; C104929:fluazuron
Engorged females; Fluazuron; Injectable route; Ivermectin; Rhipicephalus (Boophilus) microplus