Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part I: physicochemical properties in patient and simulator studies.
The objective of Part I of this analysis was to identify the relevant physicochemical characteristics of wear particles from cobalt-chromium alloy (CoCr) metal-on-metal (MoM) hip implant patients and simulator systems. For well-functioning MoM hip implants, the volumetric wear rate is low (<1mm(3) per million cycles or per year) and the majority of the wear debris is composed of oxidized Cr nanoparticles (<100nm) with minimal or no Co content. For implants with surgical malpositioning, the volumetric wear rate is as high as 100mm(3) per million cycles or per year and the size distribution of wear debris can be skewed to larger sizes (up to 1000nm) and contain higher concentrations of Co. In order to obtain data suitable for a risk assessment of wear debris in MoM hip implant patients, future studies need to focus on particle characteristics relevant to those generated in patients or in properly conducted simulator studies.


BACKGROUND
Metallic implants are very common in the field of orthopedics. Nonetheless, concerns have been raised about the implications of nano-sized particles generated from the wear of these implants. In this two-part review, the authors first attempted to identify and critically evaluate the relevant physicochemical characteristics of CoCr wear particles from hip implant patients and simulator systems. Then they evaluated in vitro and animal toxicology studies with respect to the physicochemistry and dose-relevance to metal-on-metal implant patients.
Cardno ChemRisk, Aliso Viejo, CA, USA. Electronic address: amy.madl@cardno.com.
Amy K
AK
Madl
Cardno ChemRisk, San Francisco, CA, USA. Electronic address: monty.liong@cardno.com.
Monty
M
Liong
Cardno ChemRisk, Aliso Viejo, CA, USA. Electronic address: michael.kovochich@cardno.com.
Michael
M
Kovochich
Cardno ChemRisk, Brooklyn, NY, USA.
Brent L
BL
Finley
Cardno ChemRisk, San Francisco, CA, USA.
Dennis J
DJ
Paustenbach
University of Rochester, Department of Environmental Medicine, Rochester, NY, USA.
Günter
G
Oberdörster
D000818:Animals; D002858:Chromium Alloys / Q000737:chemistry / Q000633:toxicity*; D003035:Cobalt / Q000737:chemistry / Q000633:toxicity*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008422:Materials Testing; D010316:Particle Size; D011474:Prosthesis Design; D013499:Surface Properties
D002858:Chromium Alloys; D003035:Cobalt
Cobalt-chromium; Hip implant; Metal-on-metal; Wear debris