Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome.
In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus.
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Liping
L
Peng
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Jinghua
J
Wang
Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China.
Lihong
L
Zhang
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Pan
P
Liu
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Min
M
Wang
Department of Physiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China.
Min
M
Huang
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Shengnan
S
Liu
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Pingping
P
He
Department of Neurology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Li
L
Cui
Department of Pneumology, First Affiliated Hospital of Jilin University, Changchun 130021, Jilin Province, China.
Mingxian
M
Li
Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China.
Shao
S
Wang
5-hydroxytryptamine; Purkinje cells; cerebellum; habenular nucleus; insular cortex; obstructive; sleep apnea