Analytic morphomics identifies predictors of new-onset diabetes after liver transplantation.
Among liver transplant recipients, development of post-transplant complications such as new-onset diabetes after transplantation (NODAT) is common and highly morbid. Current methods of predicting patient risk are inaccurate in the pre-transplant period, making implementation of targeted therapies difficult. We sought to determine whether analytic morphomics (using computed tomography scans) could be used to predict the incidence of NODAT. We analyzed peri-transplant scans from 216 patients with varying indications for liver transplantation, among whom 61 (28%) developed NODAT. Combinations of visceral fat, subcutaneous fat, and psoas area were considered in addition to traditional risk factors. On multivariate analysis adjusting for usual risk factors such as type of immunosuppression, subcutaneous fat thickness remained significantly associated with NODAT (OR = 1.43, 95% CI 1.00-1.88, p = 0.047). Subgroup analysis showed that patients with later-onset of NODAT had higher visceral fat, whereas subcutaneous fat thickness was more correlated with earlier-onset of NODAT (using 10 months post-transplant as the cut-off).


CONCLUSIONS
Analytic morphomics may be used to help assess NODAT risk in patients undergoing liver transplantation.
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Valerie M
VM
Vaughn
David C
DC
Cron
Michael N
MN
Terjimanian
Zachary S
ZS
Gala
Stewart C
SC
Wang
Grace L
GL
Su
Michael L
ML
Volk
D017668:Age of Onset; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D050152:Intra-Abdominal Fat / Q000473:pathology*; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D050151:Subcutaneous Fat / Q000473:pathology*; D014057:Tomography, X-Ray Computed
analytic morphomics; body composition; cirrhosis; liver disease; metabolic syndrome; new-onset diabetes after transplantation