CFH Y402H polymorphism and response to intravitreal ranibizumab in Brazilian patients with neovascular age-related macular degeneration.
OBJECTIVE
To investigate the association between CFH gene polymorphism and response to ranibizumab in Brazilian patients with neovascular age-related macular degeneration (AMD).


METHODS
95 patients were genotyped for the CFH rs1061170 (Y402H) single nucleotide polymorphism. Patients with neovascular AMD initially received intravitreal ranibizumab injections for three months and were retreated as needed. Visual acuity (VA) and central retinal thickness (CRT) were measured before treatment and at 1, 3, 6, and 12 months post-treatment.


RESULTS
For patients with the TT and TC genotypes, paired comparisons of VA showed a statistically significant improvement when the data obtained at all visits were compared with baseline. Patients homozygous for the risk genotype (CC) did not show a statistically significant improvement when VA obtained at visits 1, 3, 6 and 12 were compared with baseline. For all genotypes, paired comparisons of CRT showed a statistically significant improvement when the data obtained at visits 1, 3, 6 and 12 were compared with baseline.


CONCLUSIONS
Patients with the CC genotype showed poorer long-term functional response to intravitreal ranibizumab.
Department of Ophthalmology, Federal University of Minas Gerais, Brazil.
Carlos Eduardo
CE
Veloso
Department of Ophthalmology, Federal University of Minas Gerais, Brazil.
Luciana Negrão Frota de
LN
Almeida
Department of Ophthalmology, Federal University of Minas Gerais, Brazil.
Márcio Bittar
MB
Nehemy
D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D001938:Brazil; D017242:Complement Factor H / Q000235:genetics*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000069579:Ranibizumab / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome; D057135:Wet Macular Degeneration / Q000188:drug therapy* / Q000235:genetics*
D020533:Angiogenesis Inhibitors; D017242:Complement Factor H; D000069579:Ranibizumab