Historical exposure to persistent organic pollutants and risk of incident hypertension.
The aim of this study was to assess the influence of adipose tissue concentrations of a group of persistent organic pollutants (POPs) on the risk of hypertension in an adult cohort of residents of Granada (Southern Spain) over a 10-year follow-up. No chemical was significantly associated with the risk of hypertension in the overall population or when models were stratified by sex or median age. However, we found positive associations between log-transformed POP concentrations and hypertension risk in participants with body mass index (BMI) above the median value of 26.3kg/m(2), which were statistically significant for hexachlorobenzene (HR=1.26, 95% CI=1.03-1.56), β-hexachlorocyclohexane (HR=1.25, 95% CI=1.03-1.51), and polychlorinated biphenyl congeners -138 (HR=1.32, 95% CI=1.04-1.69) and -153 (HR=1.36, 95% CI=1.00-1.84). Inverse associations were observed in the subgroup with BMI≤26.3kg/m(2), but none was statistically significant. More research and a longer follow-up period are warranted to verify these associations and elucidate the role of obesity as a potential effect modifier. Given the elevated worldwide frequency of POP exposure and hypertension, the public health impact of this relationship may be substantial.
Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain; Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
Juan P
JP
Arrebola
Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Spain.
Mariana F
MF
Fernández
Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.Granada, Granada, Spain.
Piedad
P
Martin-Olmedo
Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, University of Copenhagen, Denmark.
Jens Peter
JP
Bonde
Department of Radiology, San Cecilio University Hospital, Granada, Spain.
José L
JL
Martín-Rodriguez
Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain.
José
J
Expósito
Gran Capitán Center for Primary Care, Virgen de las Nieves University Hospital, Granada, Spain.
Antonio
A
Rubio-Domínguez
Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain; Instituto de Investigación Biosanitaria ibs.Granada, University of Granada, San Cecilio University Hospital, Granada, Spain.
Nicolás
N
Olea
D000273:Adipose Tissue / Q000737:chemistry; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D015992:Body Mass Index; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced / Q000453:epidemiology*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D011078:Polychlorinated Biphenyls
Adipose tissue; Hypertension; Obesity; Organochlorine pesticides; Persistent organic pollutants; Polychlorinated biphenyls; Prospective study