Buccal mucosa repair with electrospun silk fibroin matrix in a rat model.
BACKGROUND
Biomimic electrospun matrix derived from silk fibroin nanofiber solution was recently prepared in our group. The feasibility of the matrix as mucosa repair scaffold was evaluated in a rat model in the present study.


METHODS
Full thickness wound was established on the buccal mucosa of male Wister rats via microscopic oral surgery. 80 rats were randomly assigned into 4 groups: (1) silk fibroin matrix, (2) commercial cowhide acellular dermal matrix (Heal-All), (3) commercial acellular dermal matrix of human skin (RENOV), and (4) vaseline gauze, respectively.


RESULTS
The silk fibroin matrix showed similar repair performance compared to the commercial acellular dermal matrices, implying promising applications in mucosa regeneration. More importantly, the silk fibroin matrix showed better wound healing ability, improved wound shrinkage inhibition, and reduced local immunological incompatibility.


CONCLUSIONS
The silk fibroin scaffold performed satisfied in scar tissue inhibition and epidermis regeneration. Taking into account its improved mechanical properties, the biomimic electrospun silk matrix could become a promising substitute of acellular dermal matrix in clinical applications.
1 Department of Stomatology, The First Affiliated Hospital of Soochow University, Suzhou - China.
Jing
J
Tang
Yongjie
Y
Han
Feng
F
Zhang
Zili
Z
Ge
Xi
X
Liu
Qiang
Q
Lu
D062088:Acellular Dermis; D000818:Animals; D040761:Biomimetic Materials; D002417:Cattle; D049109:Cell Proliferation; D005240:Feasibility Studies; D005349:Fibroins; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology / Q000601:surgery*; D057139:Nanofibers; D017208:Rats, Wistar; D013997:Time Factors; D054457:Tissue Scaffolds; D014945:Wound Healing
D005349:Fibroins