Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome.
BACKGROUND
Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies.


OBJECTIVE
This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS).


METHODS
A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m(2) (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m(2) (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment.


RESULTS
No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively; P = 0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P > 0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P = 0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P = 0.016, r = -0.229; and P = 0.006, r = -0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations.


CONCLUSIONS
Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Bercem Aycicek
BA
Dogan
National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes-Endocrine and Obesity Branch, National Institutes of Health, Bethesda, Maryland, USA.
Ayse
A
Arduc
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Mazhar Muslum
MM
Tuna
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Ersen
E
Karakılıc
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Iffet
I
Dagdelen
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Yasemin
Y
Tutuncu
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Dilek
D
Berker
Ankara Numune Training and Research Hospital, Endocrinology and Metabolism Disease, Ankara, Turkey.
Serdar
S
Guler
Androgen Hormones; Mean Platelet Volume; Polycystic Ovary Syndrome