Does treatment of Helicobacter pylori infection reduce gastric precancerous lesions?
BACKGROUND
Treatment of Helicobacter pylori (H. pylori) decreases the prevalence of gastric cancer, and may inhibit gastric precancerous lesions progression into gastric cancer. The aim of this study was to determine the effect of treatment on subsequent gastric precancerous lesion development.


METHODS
We prospectively studied 27 patients who had low grade dysplasia at the time of enrollment, in addition to dysplasia atrophic gastritis and intestinal metaplasia observed in all patients. All were prescribed quadruple therapy to treat H. Pylori infection for 10 days. Patients underwent endoscopy with biopsy at enrollment and then at follow up two years later. Biopsy samples included five biopsies from the antrum of lesser curvature, antrum of greater curvature, angularis, body of stomach and fundus. RESULTS of these biopsies were compared before and after treatment.


RESULTS
Overall, the successful eradication rate after two years was 15/27 (55.6%). After antibiotic therapy, the number of patients with low grade dysplasia decreased significantly (p=0.03), also with reduction of the atrophic lesions (p=0.01), but not metaplasia.


CONCLUSIONS
Treatment of H. pylori likely is an effective therapy in preventing the development of subsequent gastric premalignant lesions.
Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran E-mail : ghanaie@yahoo.com, ghanaei@gums.ac.ir.
Fariborz
F
Mansour-Ghanaei
Farahnaz
F
Joukar
Kourosh
K
Mojtahedi
Homayoon
H
Sokhanvar
Kourosh
K
Askari
Ahmad
A
Shafaeizadeh
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005757:Gastritis, Atrophic / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008679:Metaplasia / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*
D000900:Anti-Bacterial Agents