[Large vessels vasculopathy in systemic sclerosis].
Vasculopathy in systemic sclerosis is a severe, in many cases irreversible, manifestation that can lead to amputation. While the classical clinical manifestations of the disease have to do with the involvement of microcirculation, proximal vessels of upper and lower limbs can also be affected. This involvement of large vessels may be related to systemic sclerosis, vasculitis or atherosclerotic, and the differential diagnosis is not easy. To conduct a proper and early diagnosis, it is essential to start prompt appropriate treatment. In this review, we examine the involvement of large vessels in scleroderma, an understudied manifestation with important prognostic and therapeutic implications.
Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España. Electronic address: btejerasegura@gmail.com.
Beatriz
B
Tejera Segura
Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
Iván
I
Ferraz-Amaro
D001161:Arteriosclerosis / Q000209:etiology; D001167:Arteritis / Q000209:etiology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology; D005121:Extremities / Q000098:blood supply; D005385:Fingers / Q000098:blood supply; D006229:Hand Dermatoses / Q000209:etiology; D006801:Humans; D008833:Microcirculation; D009389:Neovascularization, Pathologic / Q000209:etiology; D020286:Pericytes / Q000473:pathology; D011928:Raynaud Disease / Q000209:etiology; D012595:Scleroderma, Systemic / Q000150:complications*; D012883:Skin Ulcer / Q000209:etiology; D014652:Vascular Diseases / Q000209:etiology*
Esclerosis sistémica; Gran vaso; Large vessels; Systemic sclerosis; Vasculopathy; Vasculopatía