[Successful treatment with azacitidine for myelodysplastic syndrome with large vessel vasculitis].
Paraneoplastic inflammation of the large vessels is a rare complication of myelodysplastic syndrome (MDS), and patients with MDS and systemic vasculitis have a poor prognosis. We present a 66-year-old male with MDS and large vessel vasculitis treated with azacitidine. Azacitidine administration improved his clinical symptoms, high fever and thickening of the arterial wall, and he achieved a complete bone marrow remission. However, 1 year later he showed progression of MDS. For MDS with vasculitis, intensive therapy, the same as that given to the high-risk group, should be considered and azacitidine administration may represent an efficacious treatment.
Department of Internal Medicine, Suita Municipal Hospital.
Mai
M
Mishima
Masanori
M
Makita
Yasuhisa
Y
Sando
Yoshikazu
Y
Yamamoto
Yasuhiro
Y
Shiote
Yoshitaka
Y
Hara
Kazuhiko
K
Yamamoto
Kenji
K
Imajo
D000368:Aged; D001374:Azacitidine / Q000008:administration & dosage / Q000627:therapeutic use*; D001853:Bone Marrow / Q000601:surgery; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D004791:Enzyme Inhibitors; D001374:Azacitidine