[A case of methotrexate-associated lymphoproliferative disorder diagnosed by liver biopsy].
In 1998, a 68-year-old woman was diagnosed with rheumatoid arthritis. She was treated with prednisolone, nonsteroidal anti-inflammatory drugs, methotrexate (MTX), and biological drugs. Retroperitoneal lymph node swelling and hepatosplenomegaly appeared but spontaneously disappeared after drug withdrawal. Anorexia and general fatigue occurred in March 2012. She was admitted to our hospital with retroperitoneal, periaortic, and mediastinal lymph node swelling and was found to have multiple liver tumors. Based on the results of aspiration biopsy of a liver tumor, she was diagnosed with malignant lymphoma (Hodgkin lymphoma). She died from liver failure and disseminated intravascular coagulation before chemotherapy. We present this case of MTX-associated lymphoproliferative disorder, which caused formation of a liver tumor.
Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine.
Mika
M
Takasumi
Ken
K
Okai
Tomoyuki
T
Asano
Yukiko
Y
Kanno
Kazumichi
K
Abe
Atsushi
A
Takahashi
Hiroko
H
Kobayashi
Yuko
Y
Hashimoto
Hiroshi
H
Watanabe
Hiromasa
H
Ohira
D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced* / Q000473:pathology*; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use
D018501:Antirheumatic Agents; D008727:Methotrexate