Development and leading-edge application of innovative photoaffinity labeling.
Photoaffinity labeling has become increasingly important with the development of powerful specific probes that are synthesized by installing a photo-activatable functional group (photophore) on the framework of biological ligands. The present review summarizes the development of diazirine-based photoaffinity labeling by focusing on its application to the structural elucidation of ligand-accepting sites within proteins.
University of Toyama.
Yasumaru
Y
Hatanaka
D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D003978:Diazomethane / Q000737:chemistry; D008024:Ligands; D008027:Light; D062105:Molecular Docking Simulation; D019920:Photoaffinity Labels / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D019920:Photoaffinity Labels; D011506:Proteins; D003978:Diazomethane; D001710:Biotin