The genome of Shigella dysenteriae strain Sd1617 comparison to representative strains in evaluating pathogenesis.
We sequenced and analyzed Shigella dysenteriae strain Sd1617 serotype 1 that is widely used as model strain for vaccine design, trials and research. A combination of next-generation sequencing platforms and assembly yielded two contigs representing a chromosome size of 4.34 Mb and the large virulence plasmid of 177 kb. This genome sequence is compared with other Shigella genomes in order to understand gene complexity and pathogenic factors.
Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand ajcharataa@gmail.com carl.mason@afrims.org vinayak@igenbio.com.
Ajchara A
AA
Vongsawan
Igenbio Inc., Chicago, IL 60607, USA.
Vinayak
V
Kapatral
Igenbio Inc., Chicago, IL 60607, USA.
Benjamin
B
Vaisvil
Igenbio Inc., Chicago, IL 60607, USA.
Henry
H
Burd
Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.
Oralak
O
Serichantalergs
Walter Reed Army Institute of Research, Division of Bacterial and Rickettsial Diseases, Silver Spring, MD 20910, USA.
Malabi M
MM
Venkatesan
Department of Enteric Diseases, Armed Forces Research Institute of Medical Sciences, Bangkok 10400, Thailand.
Carl J
CJ
Mason
D001483:Base Sequence; D002874:Chromosome Mapping; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D010957:Plasmids; D012760:Shigella / Q000235:genetics; D012762:Shigella dysenteriae / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics*
Shigella dysenteriae; comparison; genome