[Effects of sleep deprivation in hippocampal neurogenesis].
Adult neurogenesis in the dentate gyrus (DG) in the hippocampus is a process that involves proliferation, differentiation, maturation, migration, and integration of young neurons in the granular layer of DG. These newborn neurons mature in three to four weeks and incorporate into neural circuits in the hippocampus. There, these new neurons play a role in cognitive functions, such as acquisition and retention of memory, which are consolidated during sleep period. In this review, we describe recent findings that associate sleep deprivation with changes in hippocampal neurogenesis and cognitive processes. In addition, we describe possible mechanisms implicated in this deterioration such as circadian rhythm, melatonin receptors, and growth factors.
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima, Col.
Verónica
V
López-Virgen
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima, Col.
David
D
Zárate-López
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima, Col.
Fabián L
FL
Adirsch
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima, Col.
Jorge
J
Collas-Aguilar
Laboratorio de Neurociencias, Facultad de Psicología, Universidad de Colima, Col.
Óscar
Ó
González-Pérez
D000328:Adult; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology; D003071:Cognition / Q000502:physiology; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012892:Sleep Deprivation / Q000503:physiopathology*