Introducing a new radical trifluoromethylation reagent.
Perfluoro-3-ethyl-2,4-dimethyl-3-pentyl radical (PPFR) is a persistent radical stable at room temperature, but easily decomposes at 90 °C to produce a CF3 radical which is able to react with a variety of aromatic compounds to afford the corresponding trifluoromethyl derivatives, usually as mixtures of regioisomers in good to excellent overall yields.
Department of Chemistry, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, 162-8666 Tokyo, Japan.
Azusa
A
Sato
Jianlin
J
Han
Taizo
T
Ono
Alicja
A
Wzorek
José Luis
JL
Aceña
Vadim A
VA
Soloshonok
D002384:Catalysis; D005609:Free Radicals / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents