Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma.
Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma.
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Jun
J
Osugi
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuka
Y
Kimura
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuki
Y
Owada
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takuya
T
Inoue
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuzuru
Y
Watanabe
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takumi
T
Yamaura
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsuro
M
Fukuhara
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Satoshi
S
Muto
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Naoyuki
N
Okabe
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yuki
Y
Matsumura
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Takeo
T
Hasegawa
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Athushi
A
Yonechi
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mika
M
Hoshino
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsunori
M
Higuchi
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yutaka
Y
Shio
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Hiroyuki
H
Suzuki
Department of Regenerative Surgery, School of Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Mitsukazu
M
Gotoh