Anti-tick-borne encephalitis (TBE) virus neutralizing antibodies dynamics in natural infections versus vaccination.
Tick-borne encephalitis (TBE) virus infection elicits a life-long lasting protection. However, little is known about the neutralizing antibodies titres following natural infection. In this study, subjects with past TBE disease (n = 62) were analysed for the presence and titre of anti-TBE neutralizing antibodies, and compared with a vaccinated cohort (n = 101). Neutralizing antibody titres were higher in individuals with past TBE and did not show an age-dependent decrease when compared with vaccinees.
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy mariaelena.remoli@iss.it.
Maria Elena
ME
Remoli
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Antonella
A
Marchi
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Claudia
C
Fortuna
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Eleonora
E
Benedetti
National Centre for Epidemiology, Surveillance and Health Promotion, Unit of Statistics, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Giada
G
Minelli
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Cristiano
C
Fiorentini
Department of Public Health, USLL Belluno, Italy.
Rosanna
R
Mel
Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Giulietta
G
Venturi
Department of Infectious, Parasitic and Immune-Mediated Diseases, Unit of Viral Diseases and Attenuated Vaccines, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.
Maria Grazia
MG
Ciufolini
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D055815:Young Adult
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014765:Viral Vaccines
TBEV; immunity; natural infection; plaque reduction neutralization test; vaccine