Nine new diterpenes from the leaves of plantation-grown Cunninghamia lanceolata.
Nine new diterpenes named lanceolatanol hydroperoxide (1), epilanceolatanol hydroperoxide (2), lanceolatanoic acid hydroperoxide (3), epilanceolatanoic acid hydroperoxide (4), lanceolatanol (5), lanceolatanoic acid (6), 11-acetoxylanceolatanoic acid (7), 11-acetoxylanceolatanoic acid methyl ester (8) and epoxyhinokiol (13) were characterized from the leaves of plantation-grown Cunninghamia lanceolata along with twelve known compounds. The compounds were evaluated for their growth inhibitory activities against the human prostate cell line (PC-3).
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Shuangshuang
S
Zhao
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Junhong
J
Ling
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhanlin
Z
Li
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China; Huitong Experimental Station of Forest Ecology, Chinese Academy of Sciences, Huitong 418307, China.
Silong
S
Wang
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.
Jiangchun
J
Hu
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address: wangn@iae.ac.cn.
Nan
N
Wang
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D032486:Cunninghamia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D013329:Structure-Activity Relationship
D004224:Diterpenes
Abietane; Cunninghamia lanceolata; Diterpenoid; Hydroperoxide; Labdane