The role of stem cells and tissue engineering in orthopaedic sports medicine: current evidence and future directions.
The use of stem cell therapies for the treatment of orthopaedic injuries continues to advance. The purpose of this review was to provide an update of the current role and future directions of stem cell strategies in sports medicine. The application of cell-based treatments in the sports medicine arena has expanded in recent years. Promising preclinical results have led to translation of these novel therapies into the clinical setting. Early well-designed comparative clinical studies have also shown positive outcomes. Despite significant advances in this arena, there remains a need for additional high-powered and well-designed clinical trials to confirm the safety and efficacy of treatment.
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
MaCalus V
MV
Hogan
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Garth N
GN
Walker
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Liang Richard
LR
Cui
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, U.S.A.
Freddie H
FH
Fu
Stem Cell Research Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.. Electronic address: jhuard@pitt.edu.
Johnny
J
Huard
D001265:Athletic Injuries / Q000628:therapy*; D002358:Cartilage, Articular / Q000293:injuries; D006801:Humans; D007718:Knee Injuries / Q000628:therapy; D008023:Ligaments, Articular / Q000293:injuries; D009985:Orthopedics; D013178:Sports Medicine; D033581:Stem Cell Transplantation; D013708:Tendon Injuries / Q000628:therapy; D023822:Tissue Engineering