MEG analysis of neural dynamics in attention-deficit/hyperactivity disorder with fuzzy entropy.
The aim of this study was to analyze the neural dynamics in attention-deficit/hyperactivity disorder (ADHD). For this purpose, magnetoencephalographic (MEG) background activity was analyzed using fuzzy entropy (FuzzyEn), an entropy measure that quantifies signal irregularity, in 13 ADHD patients and 14 control children. Additionally, relative power (RP) was computed in conventional frequency bands (delta, theta, alpha, beta and gamma). FuzzyEn results showed that MEG activity was more regular in ADHD patients than in controls. Moreover, we found an increase of power in delta band and a decrease in the remaining frequency bands. Statistically significant differences (p-values <0.05; nonparametric permutation test for multiple comparisons) were detected for FuzzyEn in the posterior and left temporal regions, and for RP in the posterior, anterior and left temporal regions. Our results support the hypothesis that ADHD involves widespread functional brain abnormalities, affecting more areas than fronto-striatal circuits, such as the left temporal and posterior regions.
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain.
Jesús
J
Monge
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain. Electronic address: carlos.gomez@tel.uva.es.
Carlos
C
Gómez
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain; IMUVA, Instituto de Investigación en Matemáticas, Universidad de Valladolid, Valladolid, Spain.
Jesús
J
Poza
Department of Psychiatry, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain; Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Universidad Complutense de Madrid, Madrid, Spain.
Alberto
A
Fernández
Department of Psychiatry, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain; Psychiatry Service, Hospital Infanta Leonor, Madrid, Spain.
Javier
J
Quintero
Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, Universidad de Valladolid, Campus Miguel Delibes, Paseo Belén 15, 47011 Valladolid, Spain; IMUVA, Instituto de Investigación en Matemáticas, Universidad de Valladolid, Valladolid, Spain.
Roberto
R
Hornero
D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves; D002648:Child; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D012815:Signal Processing, Computer-Assisted
Attention-deficit/hyperactivity disorder; Fuzzy entropy; Magnetoencephalography; Relative power