Charting a map through the cellular reprogramming landscape.
Analysis of the molecular mechanisms underlying somatic cell reprogramming into iPSCs is hampered by low efficiency of conversion and resulting cellular heterogeneity. In this issue of Cell Stem Cell, Zunder et al. (2015) utilize mass cytometry to perform high-throughput, single-cell analyses and provide a detailed molecular roadmap of the reprogramming process.
Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: wenlu.wl@gmail.com.
Lu
L
Wen
Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: tangfuchou@pku.edu.cn.
Fuchou
F
Tang
D000818:Animals; D000943:Antigens, Differentiation; D000067470:Cellular Reprogramming Techniques; D006801:Humans; D019044:Image Cytometry / Q000379:methods*; D057026:Induced Pluripotent Stem Cells; D014157:Transcription Factors
D000943:Antigens, Differentiation; D014157:Transcription Factors