Higher levels of reactive oxygen species are associated with anergy in chronic lymphocytic leukemia.
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK a.j.linley@soton.ac.uk.
Adam
A
Linley
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK.
Beatriz
B
Valle-Argos
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK.
Andrew J
AJ
Steele
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK.
Freda K
FK
Stevenson
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK Department of Haematology, University Hospital Southampton, UK.
Francesco
F
Forconi
Cancer Research UK Centre, Cancer Sciences Unit, University of Southampton Faculty of Medicine, Southampton General Hospital, University Hospital Southampton, UK.
Graham
G
Packham
D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D017635:Clonal Anergy; D005452:Fluoresceins; D005456:Fluorescent Dyes; D015870:Gene Expression; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D017382:Reactive Oxygen Species / Q000276:immunology*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000276:immunology; D016019:Survival Analysis; D061665:Time-to-Treatment
C109098:2,7-dihydrodichlorofluorescein diacetate; D000970:Antineoplastic Agents; C527276:CXCR4 protein, human; D005452:Fluoresceins; D005456:Fluorescent Dyes; D017382:Reactive Oxygen Species; D019718:Receptors, CXCR4
ROS; anergy; chronic lymphocytic leukemia; reactive oxygen species