Lack of association between IL-6 -174G>C polymorphism and lung cancer: a meta-analysis.
The results of previous case-control studies examining the relationship between the interleukin (IL)-6 gene -174G>C polymorphism and lung cancer are controversial. In this study, we evaluated the relationship between the IL-6 gene -174G>C polymorphism and lung cancer. We selected 5 case-control studies related to the IL-6 gene -174G>C polymorphism and lung cancer by searching the PubMed, EMBase, Chinese Biomedical Literature Database, and Wanfang database. We utilized the Q-test and I2 test to determine heterogeneity between each study. To merge the odds ratios (OR) and 95% confidence intervals (CI), we utilized the fixed effects model and random effect model for analyses. The present study included 2801 patients with lung cancer and 3234 cancer-free control subjects. The meta-analysis revealed no association between the IL-6 gene -174G>C polymorphism and lung cancer in either genotype or allele distribution [CC+GC vs GG: OR = 1.04, 95%CI (0.86-1.26), P = 0.70; GG+GC vs CC: OR = 0.93, 95%CI (0.82-1.05), P = 0. 23; CC vs GG: OR = 1.08, 95%CI (0.95-1.23), P = 0.23; C allele vs D allele: OR = 1.03, 95%CI (0.96-1.11), P = 0.44]. We concluded that the IL-6 gene -174G>C polymorphism was not associated with lung cancer.
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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Y
Liu
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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XL
Song
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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GL
Zhang
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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AM
Peng
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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PF
Fu
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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P
Li
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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M
Tan
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
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X
Li
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China.
M
M
Li
Department of Respiratory Medicine, Shanghai Tenth People's Hospital of Tongi University, Zhabei, Shanghai, China liuyang8631@163.com.
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Wang
D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
D015850:Interleukin-6