[Prognostic factors of early breast cancer].
Decision about the administration of adjuvant therapy for early breast cancer depends on the evaluation of prognostic factors. Lymph node status, tumor size and grade of differentiation are classical variables in this regard, and can be complemented by hormonal receptor status and HER2 expression. These factors can be combined into prognostic indexes to better estimate the risk of relapse or death. Other factors are less important. Gene profiles have emerged in recent years to identify low-risk patients who can forgo adjuvant chemotherapy. A number of profiles are available and can be used in selected cases. In the future, gene profiling will be used to select patients for treatment with new targeted therapies.
Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
Elena
E
Almagro
Servicio de Oncología Médica, Hospital Universitario Virgen de las Nieves, Granada, España.
Cynthia S
CS
González
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, España. Electronic address: eespinosa00@hotmail.com.
Enrique
E
Espinosa
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D000066491:Clinical Decision-Making / Q000379:methods*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D011379:Prognosis
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
Breast cancer; Cáncer de mama; Factores pronósticos; Gene profiling; Perfil génico; Prognostic factors; Prognostic index; Índice pronóstico