Gargantulide A, a complex 52-membered macrolactone showing antibacterial activity from Streptomyces sp.
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.
†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, United States.
Jung-Rae
JR
Rho
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
Gurusamy
G
Subramaniam
§Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States.
Hyukjae
H
Choi
∥Division of Magnetic Resonance, Korea Basic Science Institute, Ochang, Chungbuk 363-883, Korea.
Eun-Hee
EH
Kim
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
Sok Peng
SP
Ng
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
K
K
Yoganathan
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
Siewbee
S
Ng
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
Antony D
AD
Buss
‡MerLion Pharmaceuticals, 41 Science Park Road, #04-03B the Gemini, Singapore Science Park II, Singapore 117610, Singapore.
Mark S
MS
Butler
†Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California, United States.|§Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States.
William H
WH
Gerwick
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003013:Clostridium / Q000187:drug effects; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D018942:Macrolides; C000600283:gargantulide A; D014640:Vancomycin