Theoretical treatment of helix-coil transition of complexes DNA with two different ligands having different binding parameters.
The melting transition of DNA-ligand complexes, allowing for two binding mechanisms to different DNA conformations is treated theoretically. The obtained results express the behavior of the experimentally measurable quantities, degree of denaturation, and concentrations of bound ligands on the temperature. The range of binding parameters is obtained, where denaturation curves become multiphasic. The possible application to the nanocomposites crystallization is discussed.
a Department of Physics and Electric Engineering , Yerevan State University of Architecture and Construction , Yerevan 0009 , Armenia.
Armen T
AT
Karapetian
b Departament of Electronics , Goris State University , Avangard 2, Goris, 3201 , Armenia.
Zareh A
ZA
Grigoryan
c Department of Molecular Physics , Yerevan State University , Aleq Manukyan 1, Yerevan 0025 , Armenia.
Yevgeni Sh
YSh
Mamasakhlisov
d Department of Biophysics , Yerevan State University , Aleq Manukyan 1, Yerevan 0025 , Armenia.
Mikayel V
MV
Minasyants
d Department of Biophysics , Yerevan State University , Aleq Manukyan 1, Yerevan 0025 , Armenia.
Poghos O
PO
Vardevanyan
D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D008024:Ligands; D053761:Nanocomposites / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D013696:Temperature
D008024:Ligands; D004247:DNA
DNA; DNA–ligand complexes; binding parameters; degree of denaturation; helix–coil transition