β-cyclodextrin in personal care formulations: role on the complexation of malodours causing molecules.
OBJECTIVE
The aim of this study was to prove the capability of β-cyclodextrin (β-CD) to interact with some representative molecules responsible to cause body malodour, such as carboxylic acids, thiols and steroids, present in sweat and body secretions.


METHODS
The association constants in guest-CD were determined by (1) H-NMR spectroscopy for thiols and steroids such as 3-mercapto-1-hexanol, androstenone, androstenol and androsterone, and pH-potentiometric titration for acetic acid, l(+) lactic acid, isobutyric acid, isovaleric acid and 3-hydroxy-3-methyl-hexanoic acid.


RESULTS
All considered systems are able to interact with relatively weak association constants with β-cyclodextrin, in a 1 : 1 host-guest ratio.


CONCLUSIONS
From these findings, it is possible to conclude that β-CD is capable to interact with different components present in the sweat and body secretion, forming inclusion complexes. For this reason, β-CD could be a component of body care formulations, such as deodorants.
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 4 Orabona Street, 70125, Bari, Italy.
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A
Lopedota
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 4 Orabona Street, 70125, Bari, Italy.
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A
Cutrignelli
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 4 Orabona Street, 70125, Bari, Italy.
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Laquintana
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 4 Orabona Street, 70125, Bari, Italy.
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Franco
ACRAF Angelini Research Center, Piazzale della Stazione, 00040, Santa Palomba, Roma, Italy.
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Donelli
ACRAF Angelini Research Center, Piazzale della Stazione, 00040, Santa Palomba, Roma, Italy.
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Ragni
ACRAF Angelini Research Center, Piazzale della Stazione, 00040, Santa Palomba, Roma, Italy.
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Tongiani
Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 4 Orabona Street, 70125, Bari, Italy.
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N
Denora
D003836:Deodorants / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009812:Odorants; D047392:beta-Cyclodextrins / Q000032:analysis* / Q000737:chemistry
D003836:Deodorants; D047392:beta-Cyclodextrins; C031215:betadex
NMR spectroscopy; association constant; body malodour; complexation; pH-potentiometry; β-cyclodextrin