Magnesium intake and depression in adults.
BACKGROUND
Depression is a common and often disabling disorder. Magnesium supplementation has been linked to improvement in depressive symptoms, but consensus on the relationship between magnesium and depression has not been reached.


METHODS
The purpose of this study was to test the existence of an association between dietary magnesium intake and depression in the adult US population. A cross-sectional, population-based data set (National Health and Nutrition Examination Survey) was used to explore the relationship of magnesium intake and depression in 8894 US adults (mean age, 46.1 years; 47.4% men) from 2007 to 2010. Using logistic regression to model the relationship between the presence of depression (Patient Health Questionnaire score ≥5) and low magnesium intake (<184 mg/day), we examined the risk ratio (RR) of magnesium intake and its 95% confidence interval.


RESULTS
After adjusting for all potential confounders, the strength of the association of very low magnesium intake with depression was statistically significant (RR = 1.16; 95% CI, 1.06-1.30). Adjusting for all other covariates, low magnesium intake was associated with depression in subjects younger than age 65 (RR, 1.22; 95% CI, 1.06-1.40; P = .007) but seemed to be protective in seniors (RR, 0.75; 95% CI, 0.56-0.98; P = .032).


CONCLUSIONS
We found a significant association between very low magnesium intake and depression, especially in younger adults. The finding of the potential protective effect of low magnesium intake in older adults is surprising and warrants further investigation.
From the Center for Clinical and Translational Science, University of Vermont, Burlington. emily.tarleton@uvm.edu.
Emily K
EK
Tarleton
From the Center for Clinical and Translational Science, University of Vermont, Burlington.
Benjamin
B
Littenberg
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003863:Depression / Q000178:diet therapy / Q000453:epidemiology*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015994:Incidence; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D014707:Vermont / Q000453:epidemiology
D008274:Magnesium
Depression; Dietary Supplements; Nutritional Sciences