Regulation of gene expression and pain states by epigenetic mechanisms.
The induction of inflammatory or neuropathic pain states is known to involve molecular activity in the spinal superficial dorsal horn and dorsal root ganglia, including intracellular signaling events which lead to changes in gene expression. These changes ultimately cause alterations in macromolecular synthesis, synaptic transmission, and structural architecture which support central sensitization, a process required for the establishment of long-term pain states. Epigenetic mechanisms are essential for long-term synaptic plasticity and modulation of gene expression. This is because epigenetic modifications are known to regulate gene transcription by aiding the physical relaxation or condensation of chromatin. These processes are therefore potential regulators of the molecular changes underlying permanent pain states. A handful of studies have emerged in the field of pain epigenetics; however, the field is still very much in its infancy. This chapter draws upon other specialities which have extensively investigated epigenetic mechanisms, such as learning and memory and oncology. After defining epigenetics as well as the recent field of "neuroepigenetics" and the main molecular mechanisms involved, this chapter describes the role of these mechanisms in the synaptic plasticity seen in learning and memory, and address those epigenetic mechanisms that have been linked with the development of acute and prolonged pain states. Finally, the idea that long-lasting epigenetic modifications could contribute to the transition from acute to chronic pain states by supporting maladaptive molecular changes is discussed.
Department of Cell and Developmental Biology, University College London, London, United Kingdom. Electronic address: ucgasmg@ucl.ac.uk.
Sandrine M
SM
Géranton
Department of Cell and Developmental Biology, University College London, London, United Kingdom.
Keri K
KK
Tochiki
D000818:Animals; D044127:Epigenesis, Genetic; D006801:Humans; D008568:Memory / Q000502:physiology; D008957:Models, Genetic; D009473:Neuronal Plasticity / Q000235:genetics; D010146:Pain / Q000235:genetics*
Central sensitization; Chromatin; DNA methylation; Epigenetic; Histone modification; Synaptic plasticity