Multimodal treatment and management strategies for intracranial hemangiopericytoma.
Intracranial hemangiopericytoma (HPC) is a rare malignant meningothelial tumor. The authors retrospectively reviewed the long-term clinical outcomes of patients with HPC with regard to treatment modalities and histopathological grades. Eighteen women and 20 men (mean age 38.5 years, range, 18-62 years) were observed over an average follow-up period of 61 months (range, 15-133 months) between 2003 and 2013. The initial treatment modalities included total tumor resection followed by conventional radiotherapy (RT) (n=27), and subtotal tumor resection followed by stereotactic radiosurgery (n=11). One patient (3%) had permanent neurological deficits, and six patients (16%) died. Thirteen patients (34%) suffered recurrence. One year, 5 year, and 10 year recurrence-free survival rates were 100%, 70%, and 39%, respectively. Five patients (13%) developed metastasis. One year, 5 year, and 10 year metastasis-free survival rates were 100%, 89%, 74%, respectively. Low grade tumors were associated with longer overall survival, recurrence-free interval and metastasis-free interval (log-rank, p<0.05). Radical resection with RT was associated with longer overall survival and recurrence-free interval (log-rank, p<0.05), but had no effect on the metastasis-free interval (log-rank, p=0.245). Thus, radical surgery followed by adjuvant RT is the primary treatment of HPC, but recurrence and metastasis remain a common treatment outcome regardless of initial strategy. It is necessary to maintain long-term follow-up and serial imaging for all patients with intracranial HPC after treatment, regardless of extent of resection.
Department of Neurosurgery, The Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Li-feng
LF
Chen
Department of Geriatric Neurology, The Chinese PLA General Hospital, Haidian District, Beijing, China.
Yang
Y
Yang
Department of Neurosurgery, The Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. Electronic address: javelins@126.com.
Xin-guang
XG
Yu
Department of Pathology,The Chinese PLA General Hospital, Haidian District, Beijing, China.
Qiu-ping
QP
Gui
Department of Neurosurgery, The Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Bai-nan
BN
Xu
Department of Neurosurgery, The Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Ding-biao
DB
Zhou
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D005260:Female; D006393:Hemangiopericytoma / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
Hemangiopericytoma; Radiotherapy; Recurrence; Surgery; Survival