JCV-specific T-cells producing IFN-gamma are differently associated with PmL occurrence in HIV patients and liver transplant recipients.
Aim of this work was to investigate a possible correlation between the frequency of JCV-specific T-cells and PML occurrence in HIV-infected subjects and in liver transplant recipients. A significant decrease of JCV-specific T-cells was observed in HIV-PML subjects, highlighting a close relation between JCV-specific T-cell immune impairment and PML occurrence in HIV-subjects. Interestingly, liver-transplant recipients (LTR) showed a low frequency of JCV-specific T-cells, similar to HIV-PML subjects. Nevertheless, none of the enrolled LTR developed PML, suggesting the existence of different immunological mechanisms involved in the maintenance of a protective immune response in LTR.
Cellular Immunology Laboratory, INMI L. Spallanzani, Rome, Italy.
Chiara
C
Agrati
Luciano
L
Izzo
Giulia
G
Berno
Eleonora
E
Cimini
Veronica
V
Bordoni
Maria L
ML
Giancola
Francesco
F
Baldini
Marco
M
Colasanti
Giuseppe M
GM
Ettorre
Paolo
P
Izzo
Federico
F
Pugliese
Marco
M
Angrisani
Pierfrancesco
P
Di Cello
Maria R
MR
Capobianchi
Antonio
A
Bolognese
D000328:Adult; D000368:Aged; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000601:surgery / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology*; D007577:JC Virus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology / Q000276:immunology* / Q000821:virology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D066027:Transplant Recipients
D007371:Interferon-gamma