Different outcomes after intracytoplasmic sperm injection without oocyte activation in two patients with different types of globozoospermia.
Different outcomes after intracytoplasmic sperm injection (ICSI) without oocyte activation in two patients with different types of round-headed spermatozoa (globozoospermia) are reported. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were underwent ICSI without oocyte activation and a 33.33% (4/12) fertilisation rate was obtained in the first case, whereas an abnormal fertilisation was achieved in the second case. The transfer of two grade II embryos in the first couple resulted in clinical pregnancy with a healthy livebirth. It was concluded that the main problem of cases with globozoospermia was a low fertilisation rate or failure fertilisation, and even though ICSI and artificial oocyte activation have been employed to increase this rate, it is not necessarily needed to achieve a pregnancy.
Department of Human Assisted Reproductive, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, China.
Z-Q
ZQ
Zhang
Department of Gynecological Oncology, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, China.
S-G
SG
Long
Department of Human Assisted Reproductive, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, China.
Z-H
ZH
Huang
Department of Human Assisted Reproductive, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, China.
C-L
CL
Xin
Department of Human Assisted Reproductive, Jiangxi Maternity and Child Healthcare Hospital, Nanchang City, Jiangxi, China.
Q-F
QF
Wu
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D013094:Spermatozoa / Q000002:abnormalities*
Acrosome; assisted oocyte activation; globozoospermia; human assisted reproductive technology; intracytoplasmic sperm injection