Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates.
Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E(∗), ΔH(∗), ΔS(∗) and ΔG(∗) were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi.
Department of Chemistry, Faculty of Science, Taif University, Al-Hawiah, Taif, P.O. Box 888, 21974, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt. Electronic address: msrefat@yahoo.com.
Moamen S
MS
Refat
Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
Fathi M
FM
Al-Azab
Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
Hussein M A
HM
Al-Maydama
Faculty of Dentistry, Nahda University, Egypt.
Ragab R
RR
Amin
Department of Chemistry, Faculty of Science, Sana'a University, Yemen.
Yasmin M S
YM
Jamil
Department of Chemistry, Faculty of Science, Taif University, Al-Hawiah, Taif, P.O. Box 888, 21974, Saudi Arabia; Faculty of Agriculture, Biochemistry Department, Cairo University, Giza, Egypt.
Mohamed I
MI
Kobeasy
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000494:pharmacology; D008687:Metformin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D000890:Anti-Infective Agents; D002614:Chelating Agents; D056831:Coordination Complexes; D028581:Lanthanoid Series Elements; D008687:Metformin
Antibacterial; Florescence; Metformin; Spectroscopic; Thermal