Effects of low-dose cadmium exposure during gestation and lactation on development and reproduction in rats.
Cadmium (Cd) is an important toxic chemical due to its increasing levels in the environment and its resulting accumulation in humans and animals. The present study was performed to evaluate the long-term effects of low doses of Cd administered in offspring by oral route to rats during pregnancy and lactation. There were no adverse effects on the physical and sexual development in the pups, except to delay the development of offspring. The relative weights of livers and kidneys in the adult female offspring were significantly decreased after exposure to 10 ppm Cd. These results indicated that there were adverse effects on growth and development from exposure to 5 or 10 ppm Cd in utero and during lactation. The results also showed differential gender sensitivity effects on the organ weights.
Institute of Tropical Medicine, Third Military Medical University, Chongqing, 400038, People's Republic of China.
Xue
X
Luo
Lianbing
L
Li
Mingfu
M
Ma
Renyan
R
Li
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000254:growth & development; D007774:Lactation; D008099:Liver / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008431:Maternal-Fetal Exchange; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*; D012737:Sex Factors
D002104:Cadmium