Increased audiovisual integration in cochlear-implanted deaf patients: independent components analysis of longitudinal positron emission tomography data.
It has been demonstrated in earlier studies that patients with a cochlear implant have increased abilities for audio-visual integration because the crude information transmitted by the cochlear implant requires the persistent use of the complementary speech information from the visual channel. The brain network for these abilities needs to be clarified. We used an independent components analysis (ICA) of the activation (H2(15)O) positron emission tomography data to explore occipito-temporal brain activity in post-lingually deaf patients with unilaterally implanted cochlear implants at several months post-implantation (T1), shortly after implantation (T0) and in normal hearing controls. In between-group analysis, patients at T1 had greater blood flow in the left middle temporal cortex as compared with T0 and normal hearing controls. In within-group analysis, patients at T0 had a task-related ICA component in the visual cortex, and patients at T1 had one task-related ICA component in the left middle temporal cortex and the other in the visual cortex. The time courses of temporal and visual activities during the positron emission tomography examination at T1 were highly correlated, meaning that synchronized integrative activity occurred. The greater involvement of the visual cortex and its close coupling with the temporal cortex at T1 confirm the importance of audio-visual integration in more experienced cochlear implant subjects at the cortical level.
Université Toulouse, CerCo, Université Paul Sabatier, Toulouse, France; Cerveau & Cognition, CNRS UMR 5549, Faculté de Médecine de Purpan, Pavillon Baudot, CHU Purpan, BP 25202, 31052, Toulouse, France; Service d'Oto-Rhino-Laryngologie et Oto-Neurologie, Hopital Purpan, Toulouse, France.
K
K
Strelnikov
J
J
Rouger
S
S
Lagleyre
B
B
Fraysse
J-F
JF
Démonet
O
O
Déguine
P
P
Barone
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001307:Auditory Perception; D016022:Case-Control Studies; D003054:Cochlear Implants; D003638:Deafness / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D013702:Temporal Lobe / Q000000981:diagnostic imaging*; D014793:Visual Cortex / Q000000981:diagnostic imaging*; D014796:Visual Perception
audio-visual; cochlear implantation; multisensory; neuroimaging; positron emission tomography; speech