Unique case of sporadic multiple gastro intestinal stromal tumour.
BACKGROUND
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and they derived from transformed neoplastic precursors of Cajal's interstitial cell (ICC).


METHODS
We are presenting a sporadic and exemplary case of 42 multiple GISTs in a young female patient. Our patient showed anemia for the gastric GIST bleeding and only after other tumors were instrumentally and intra-surgery discovered. The patient showed genetic mutation V559A/1676 T>C of the juxtamembrane domain of the exon 11 causing the replacement of Valine with Alanine in the 559 codon.


CONCLUSIONS
GISTS estimated annual incidence is 12-14 per million. Multiple GISTs associated with familiarity or hereditary syndromes are described only in few case reports and sporadic mGISTs have not been studied yet. Literature review has been done.


CONCLUSIONS
We are presenting a sporadic and exemplary case of 42 multiple GISTs in a young female patient localized trough out all the gastrointestinal tract. This is the only case of sporadic multiple GISTs reported in literature.
General and Emergency Surgery, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy. Electronic address: luiginagraziosi@yahoo.it.
Luigina
L
Graziosi
General and Emergency Surgery, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy.
Elisabetta
E
Marino
Clinical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy.
Vienna
V
Ludovini
Radiology Unit, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy.
Alberto
A
Rebonato
Clinical Oncology, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy.
Verena De
VD
Angelis
General and Emergency Surgery, Santa Maria della Misericordia Hospital, University of Perugia, Via dottori, 06134 Perugia, Italy.
Annibale
A
Donini
Gastrointestinal stromal tumour; Multiple gist; V559A/1676 T>C