H₂S and substance P in inflammation.
Hydrogen sulfide (H2S) and substance P play a key role in inflammation. Using animal models of inflammation of different etiologies such as acute pancreatitis, sepsis, burns, and joint inflammation, studies have recently shown an important role of the proinflammatory action of H2S and substance P. Also, H2S contributes to inflammation in different conditions via substance P. This chapter reviews methods and key data that have led to our current understanding of the role of H2S and substance P in inflammation.
Department of Pathology, University of Otago, Christchurch, New Zealand. Electronic address: madhav.bhatia@otago.ac.nz.
Madhav
M
Bhatia
D000208:Acute Disease; D000818:Animals; D002056:Burns / Q000378:metabolism / Q000473:pathology*; D002351:Carrageenan; D002108:Ceruletide; D004195:Disease Models, Animal; D004357:Drug Synergism; D004487:Edema / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D019446:Endotoxemia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D006862:Hydrogen Sulfide / Q000009:adverse effects* / Q000378:metabolism; D008070:Lipopolysaccharides; D055370:Lung Injury / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D010195:Pancreatitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D013373:Substance P / Q000009:adverse effects* / Q000096:biosynthesis
D008070:Lipopolysaccharides; D013373:Substance P; D002108:Ceruletide; D002351:Carrageenan; D006862:Hydrogen Sulfide
Acute pancreatitis; Burn injuries; Hydrogen sulfide; Inflammation; Joint inflammation; Sepsis; Substance P