Contribution of fatty acid transporter (CD36) genetic variant rs1761667 to body mass index, the TAMRISK study.
BACKGROUND
Human fatty acid transporter CD36 gene variations have previously been associated with fat preferences and obesity. These variations could thus cause overweight and hypothetically lead to hypertension. The association of CD36 SNP rs1761667 with body mass index (BMI) and hypertension was therefore studied in a Finnish cohort of adults.


METHODS
The data were collected from the Tampere adult population cardiovascular risk study (TAMRISK). A total of 314 cases with diagnosed hypertension, and 422 non-hypertensive healthy controls were selected from a Finnish periodic 50-year-old health examination cohort. Most subjects had prior health examination data also from their 40- and 45-year examinations. DNA was extracted from buccal swabs and the human CD36 genetic variant was analyzed using KASP genotyping.


RESULTS
The CD36 SNP rs1761667 variant AA was significantly associated with lower BMI, as compared to variants AG and GG at the ages of 40-, 45-, and 50 years (p < 0.001, p = 0.005 and p = 0.013, respectively). No association of this CD36 variation with hypertension was found.


CONCLUSIONS
CD36 rs1761667 was associated with BMI in the TAMRISK study. Considering the multitude of roles of CD36 in processes related to fatty acid metabolism and sensing in the body, it is plausible that genetic variation in human fatty acid transporter CD36 can have effects on regulation of energy homeostasis.
Department of Medical Biochemistry, University of Tampere Medical School and Fimlab Laboratories , Tampere , Finland.
Tiina
T
Solakivi
Tarja
T
Kunnas
Seppo T
ST
Nikkari
D015992:Body Mass Index; D018955:CD36 Antigens / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000235:genetics*; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D018955:CD36 Antigens
CD36 fatty acid transporter; health surveys; hypertension; obesity; single nucleotide polymorphism