[Development of eosinophilic pneumonia in a patient with latent tuberculosis infection resulting from isoniazid].
We report a 37-year-old patient with latent tuberculosis infection who received isoniazid (INH) antituberculosis chemoprophylaxis. However, he developed fever and productive cough 3 weeks after treatment. Chest radiography and computed tomography showed bilateral infiltrative shadows in upper fields. Bronchoalveolar lavage fluid revealed a high proportion of eosinophils, and histological examination of biopsied lung tissue showed interstitial thickening with eosinocyte infiltration. Based on these findings, the patient was diagnosed with drug-induced eosinophilic pneumonia. His febrile condition and dry cough resolved after discontinuation of INH. Chest X-rays showed improvement of infiltrative shadows. This case report highlights the potential for INH-induced pneumonitis during the course of antituberculosis chemoprophylaxis.
Nobuaki
N
Umeda
Yuya
Y
Inada
Takashi
T
Mamoto
D000328:Adult; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000188:drug therapy*; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000995:Antitubercular Agents; D007538:Isoniazid