Altered serous levels of monoamine neurotransmitter metabolites in patients with refractory and non-refractory depression.
The study examined plasma metabolite changes of monoamine neurotransmitters in patients with treatment-resistant depression (TRD) and non-TRD before and after therapy. All 30 TRD and 30 non-TRD patients met the diagnostic criteria for a depressive episode in accordance with the International Classification of Diseases, Tenth Revision. Before treatment, and at 4, 6, and 8 weeks after treatment, the plasma metabolite products of monoamine neurotransmitters in TRD group, including 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl ethylene glycol and homovanillic acid, were significantly lower than those in the non-TRD group. After two types of anti-depressive therapy with 5-serotonin and norepinephrine reuptake inhibitor, combined with psychotherapy, the Hamilton Depression Rating Scale scores were significantly reduced in both groups of patients, and the serous levels of 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenyl ethylene glycol were significantly increased. In contrast, the homovanillic acid level exhibited no significant change. The levels of plasma metabolite products of peripheral monoamine neurotransmitters in depressive patients may predict the degree of depression and the therapeutic effects of treatment.
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Guiqing
G
Zhang
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Yanxia
Y
Zhang
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Jianxia
J
Yang
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Min
M
Hu
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Yueqi
Y
Zhang
Department of Rehabilitation and Psychology, the First Affiliated Hospital of Shihezi University Medical College, Shihezi 832008, Xinjiang Uygur Autonomous Region, China.
Xia
X
Liang
3-methoxy-4-hydroxyphenyl ethylene glycol; 5-hydroxyindoleacetic acid; homovanillic acid; monoamine neurotransmitter; treatment-resistant depression