Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population.
The ZNF217 gene, a potential oncogene amplified and overexpressed in several cancers including colorectal cancer (CRC), acts as a transcription factor that activates or represses target genes. The polymorphisms rs16998248 (T>A) and rs35720349 (C>T) in coronary artery disease have been associated with reduced expression of ZNF217. In this study, we analyzed the 2 polymorphisms in Mexican patients with CRC. Genotyping of rs16998248 and rs35720349 sites was performed by polymerase chain reaction-restriction fragment length polymorphism in 203 Mexican Mestizos, 101 CRC patients, and 102 healthy blood donors. Although no statistical differences regarding genotype and allele frequencies of ZNF217 polymorphisms were observed (P > 0.05), linkage disequilibrium was significant in CRC patients (r(2) = 0.39, P < 0.0001), as a result of reduced AC haplotype frequency. Thus, the AC haplotype may protect against CRC.
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
R
R
Ramírez-Ramírez
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
M
M
Gutiérrez-Angulo
División de Genética, CIBO, IMSS, Guadalajara, Jalisco, México.
M T
MT
Magaña
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
J M
JM
Moreno-Ortiz
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
M
M
Partida-Pérez
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
R
R
Muñiz-Mendoza
Laboratorio de Inmunobiología, CUCBA, Universidad de Guadalajara, Zapopan, Jalisco, México.
J
J
Peregrina-Sandoval
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México.
A S
AS
Suárez-Villanueva
Servicio de Colon y Recto, "Juan I. Menchaca" Hospital Civil, Guadalajara, Jalisco, México.
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M
Centeno-Flores
Servicio de Colon y Recto, "Juan I. Menchaca" Hospital Civil, Guadalajara, Jalisco, México.
V M
VM
Maciel-Gutiérrez
Servicio de Oncología "Fray Antonio Alcalde" Hospital Civil, Guadalajara, Jalisco, México.
E
E
Cabrales-Vazquez
Instituto de Genética Humana and Doctorado en Genética Humana, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, México ayama1624@yahoo.com.mx.
M L
ML
Ayala-Madrigal
D063646:Carcinogenesis / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008800:Mexico; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*
D015534:Trans-Activators; C113698:ZNF217 protein, human