Nickel-catalyzed asymmetric transfer hydrogenation of hydrazones and other ketimines.
We report the use of nickel catalysts for the catalytic transfer hydrogenation of hydrazones and other ketimines with formic acid. Strongly donating bisphosphines must be used to support the catalysts. As in enzymatic catalysis, attractive weak interactions may be important for stereochemical control by the nickel/binapine catalyst.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371 (Singapore).
Haiyan
H
Xu
Peng
P
Yang
Pratanphorn
P
Chuanprasit
Hajime
H
Hirao
Jianrong Steve
JS
Zhou
D002384:Catalysis; D018360:Crystallography, X-Ray; D005561:Formates / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry; D013237:Stereoisomerism
D005561:Formates; D006835:Hydrazones; D007097:Imines; D009570:Nitriles; D010720:Phosphines; C542835:ketimine; C030544:formic acid; D009532:Nickel
asymmetric catalysis; hydrazones; hydride insertion; nickel; transfer hydrogenation