Adrenergic receptor β2 activation by stress promotes breast cancer progression through macrophages M2 polarization in tumor microenvironment.
Stress and its related hormones epinephrine (E) and norepinephrine (NE) play a crucial role in tumor progression. Macrophages in the tumor microenvironment (TME) polarized to M2 is also a vital pathway for tumor deterioration. Here, we explore the underlying role of macrophages in the effect of stress and E promoting breast cancer growth. It was found that the weight and volume of tumor in tumor bearing mice were increased, and dramatically accompanied with the rising E level after chronic stress using social isolation. What is most noteworthy, the number of M2 macrophages inside tumor was up-regulated with it. The effects of E treatment appear to be directly related to the change of M2 phenotype is reproduced in vitro. Moreover, E receptor ADRβ2 involved in E promoting M2 polarization was comprehended simultaneously. Our results imply psychological stress is influential on specific immune system, more essential for the comprehensive treatment against tumors.
School of Medicine, Nankai University; State Key Laboratory of Medical Chemical Biology, Nankai University, Tianjin 300071, PR China.
Jun-fang
JF
Qin
School of Medicine, Nankai University, Tianjin 300071, PR China.
Feng-jiao
FJ
Jin
School of Medicine, Nankai University, Tianjin 300071, PR China.
Ning
N
Li
School of Medicine, Nankai University; State Key Laboratory of Medical Chemical Biology, Nankai University, Tianjin 300071, PR China.
Hai-tao
HT
Guan
Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300071, PR China.
Lan
L
Lan
School of Medicine, Nankai University; State Key Laboratory of Medical Chemical Biology, Nankai University, Tianjin 300071, PR China.
Hong
H
Ni
School of Medicine, Nankai University, Tianjin 300071, PR China.
Yue
Y
Wang
D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018343:Receptors, Adrenergic, beta-2 / Q000378:metabolism*; D012934:Social Isolation; D013315:Stress, Psychological; D059016:Tumor Microenvironment; D014945:Wound Healing
D018343:Receptors, Adrenergic, beta-2