VHL: Cullin-g the hypoxic response.
Hypoxia inducible factor (HIF)-mediated response to hypoxic conditions is turned off by VHL-mediated ubiquitination of HIFα. To achieve this, VHL binds HIFα and recruits it to a specific E3 ubiquitin ligase complex, a Cullin-RING-ligase. In this issue of Structure, Nguyen et al. provide a structural view of how VHL engages the ligase in order to inhibit the hypoxic response.
The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia.
Nadia J
NJ
Kershaw
The Walter and Eliza Hall Institute of Medical Research and Department of Medical Biology, University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: babon@wehi.edu.au.
Jeffrey J
JJ
Babon
D006801:Humans; D014157:Transcription Factors / Q000737:chemistry*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000737:chemistry*
D014157:Transcription Factors; D051794:Von Hippel-Lindau Tumor Suppressor Protein