Studying NF-κB signaling with mathematical models.
Mathematical modeling of NF-κB signaling can be employed to understand how the network of molecular interactions leads to signaling phenomena observed experimentally. Model construction is a challenging process; however, existing models can be utilized and can provide a great deal of insight quickly and inexpensively. The simulation of various inputs and the identification of potential therapeutic targets using the mathematical model are detailed here.
Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, 90025, USA.
Simon
S
Mitchell
Rachel
R
Tsui
Alexander
A
Hoffmann
D003198:Computer Simulation; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction
D016328:NF-kappa B