Value of 18-F-FDG PET/CT and CT in the Diagnosis of Indeterminate Adrenal Masses.
The purpose of this paper was to study the value of 18-FDG PET/CT and reassess the value of CT for the characterization of indeterminate adrenal masses. 66 patients with 67 indeterminate adrenal masses were included in our study. CT/MRI images and 18F-FDG PET/CT data were evaluated blindly for tumor morphology, enhancement features, apparent diffusion coefficient values, maximum standardized uptake values, and adrenal-to-liver maxSUV ratio. The study population comprised pathologically confirmed 16 adenomas, 19 metastases, and 32 adrenocortical carcinomas. Macroscopic fat was observed in 62.5% of the atypical adenomas at CT but not in malignant masses. On 18F-FDG PET/CT, SUVmax and adrenal-to-liver maxSUV ratio were significantly lower in adenomas than in malignant tumors. An SUVmax value of less than 3.7 or an adrenal-to-liver maxSUV ratio of less than 1.29 is highly predictive of benignity.
Department of Radiology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France ; Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France.
Nathalie
N
Launay
Department of Radiology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Stéphane
S
Silvera
Department of Nuclear Medicine, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Florence
F
Tenenbaum
Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France ; Department of Endocrinology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Lionel
L
Groussin
Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France ; Department of Anatomopathology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Frédérique
F
Tissier
Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France ; Department of Epidemiology and Biostatistics, Hôtel Dieu University Hospital, 1 Parvis Notre Dame-place Jean Paul II, 75004 Paris, France.
Etienne
E
Audureau
Department of Radiology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France ; Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France.
Olivier
O
Vignaux
Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France ; Department of Digestive and Endocrine Surgery, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Bertrand
B
Dousset
Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France ; Department of Endocrinology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France.
Xavier
X
Bertagna
Department of Radiology, Cochin University Hospital, 27 rue du Faubourg St. Jacques, 75014 Paris, France ; Sorbonne Paris Cité, Université Paris Descartes, 12 rue de l'École de Medicine, 75006 Paris, France.
Paul
P
Legmann