Revisiting hippocampal sclerosis in mesial temporal lobe epilepsy according to the "two-hit" hypothesis.
Hippocampal sclerosis (HS) is the most common neuropathological pattern observed in pharmacoresistant epilepsy and represents a critical feature in mesial temporal lobe epilepsy syndrome. However, its pathophysiological mechanisms and neuropathological consequences on seizures remain mostly unresolved. The new international classification of hippocampal sclerosis aims at standardizing its description to allow comparisons between different clinical studies. However, several aspects are not considered in this classification (granule cell dispersion, sprouting, glial modifications…). In this chapter, we discuss these different features associated with hippocampal sclerosis in perspective with the "two-hit" hypothesis and propose mechanisms that could be involved in the modulation of some specific neuropathological aspects like early life stress, hyperthermic seizures, brain lesions or hormonal modifications.
Inserm, U836, université Joseph-Fourier, dite Santé, bâtiment Edmond-J.-Safra, chemin Fortuné-Ferrini, 38706 La Tronche cedex, France; University Grenoble-Alpes, Grenoble institut des neurosciences, chemin Fortuné-Ferrini, 38700 La Tronche, France; Hôpital Pierre-Oudot, 30, avenue du Médipôle, BP 40348, 38302 Bourgoin-Jallieu cedex, France. Electronic address: sophie.hamelin@ujf-grenoble.fr.
S
S
Hamelin
Inserm, U836, université Joseph-Fourier, dite Santé, bâtiment Edmond-J.-Safra, chemin Fortuné-Ferrini, 38706 La Tronche cedex, France; University Grenoble-Alpes, Grenoble institut des neurosciences, chemin Fortuné-Ferrini, 38700 La Tronche, France; CHU de Grenoble, avenue Maquis-du-Grésivaudan, 38700 La Tronche, France.
A
A
Depaulis
D004833:Epilepsy, Temporal Lobe / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D019599:Mossy Fibers, Hippocampal / Q000473:pathology; D017966:Pyramidal Cells / Q000473:pathology; D012598:Sclerosis
Bourgeonnement des fibres moussues; Crises fébriles; Dispersion des cellules granulaires; Epileptogenesis; Febrile seizures; Granular cell dispersion; Hippocampal sclerosis; Hippocampus; Hypothèse du « double choc »; Mesial temporal lobe epilepsy; Mossy fiber sprouting; Sclérose de l’hippocampe; Two-hit hypothesis; Épilepsie mésio-temporale; Épileptogenèse