Pulmonary artery intimal sarcoma diagnosed using endobronchial ultrasound-guided transbronchial needle aspiration.
Intimal sarcoma of the pulmonary artery is a rare intraluminal malignant neoplasm that has an aggressive biological behavior, and early diagnosis may improve patient outcome. We describe a case of pulmonary artery intimal sarcoma diagnosed on cytologic material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) biopsy with rapid on-site evaluation (ROSE). The aspirate showed loosely cohesive clusters of pleomorphic malignant spindled and epithelioid cells. An immunostain panel did not demonstrate any definitive mesenchymal or epithelial differentiation. The tumor's intraluminal origin was supported by radiographic imaging studies. Subsequently, the patient received preoperative chemotherapy and underwent tumor resection with reconstruction. This report describes the cytomorphologic features of this rare intravascular tumor and demonstrates how EBUS-TBNA with ROSE was instrumental in obtaining optimal cytologic sampling for ancillary studies, thus expediting the management.
Address: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Nancy P
NP
Caraway
Department of Pathology, University of British Columbia, Royal Jubilee Hospital, Victoria, BC V8R 1J8, Canada.
Davide
D
Salina
Department of Pathology and Immunology, The Houston Methodist Hospital, Weill Cornell Medical College, Houston, Texas 77030, USA.
Michael T
MT
Deavers
Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Rodolfo
R
Morice
Address: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Gene
G
Landon
Cytology; endobronchial ultrasound-guided transbronchial needle aspiration; fine-needle aspiration; intimal sarcoma; pulmonary artery sarcoma