Adenoid cystic carcinoma of the larynx: a report of six cases with review of the literature.
CONCLUSIONS
Adenoid cystic carcinoma (ACC) in the larynx is an extremely rare entity. Although the 5-year disease-specific survival rates for laryngeal ACC are high, distant metastasis might occur up to more than 5 years post treatment. Therefore patients with ACC require long-term follow-up.


OBJECTIVE
To summarize the characteristics of laryngeal ACC by analyzing six cases in a single center.


METHODS
This was a retrospective analysis of six patients with laryngeal ACC who were treated in Beijing Tongren Hospital between 1998 and 2013.


RESULTS
The mean age at diagnosis was 44 years, ranging from 15 to 61 years. Dyspnea was the most common complaint. All patients underwent combined-modality treatment with surgical resection and external beam radiation. The range of follow-up time varied from 1 to 7 years (median 5 years). Follow-up inspections indicated that none of them had local or regional recurrence. Distant metastasis occurred in 33.7% (2/6) of the patients, with one lung metastasis 5 years after operation and one liver metastasis 4 years after operation.
Department of Otolaryngology, Beijing Children's Hospital, Capital Medical University, Beijing Pediatric Research Institute, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery.
Wei
W
Liu
Xiaohong
X
Chen
D000293:Adolescent; D000328:Adult; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy / Q000401:mortality; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
Treatment; dyspnea; follow-up; laryngeal carcinoma