CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke.
The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene. The genotype and haplotype distributions were compared between the case and control groups. We found that the GG genotype of rs2108622 in the CYP4F2 gene was associated with risk of IS (P = 0.023). Haplotype analysis indicated that the GGGT haplotype comprising rs2108622-rs3093100-rs3093105-rs3093135 was associated with IS, which suggests that the GGGT haplotype may be a risk factor for IS (P = 0.012). CYP4F2 gene polymorphism might increase the risk of IS in the Chinese population.
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China yanhai_qing@yeah.net.
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Yan
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.
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Y
Yuan
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.
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P
Zhang
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.
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Z
Huang
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.
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Chang
Department of Neurosurgery, PuEr Municipal Hospital, PuEr, Yunnan Province, China.
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YK
Gui
D002545:Brain Ischemia / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000201:enzymology / Q000235:genetics*
D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human