HIV-associated primary effusion lymphoma presenting as a paracardial mass.
Primary effusion lymphoma (PEL), a rare type of non-Hodgkin's lymphoma, is an AIDS-defining illness and always associated with human herpesvirus 8 (HHV-8). Classic presentations involve the pleural, pericardial or peritoneal cavities. Infrequently, extracavitary solid tumours develop. Treatment of PEL requires chemotherapy and highly active antiretroviral therapy (HAART). We report a case of a 46-year-old man, who presented with right-sided chest pain, dyspnoea and night sweats. Evaluation revealed decreased breath sounds and dullness to percussion on the right side of the chest. Imaging demonstrated a 6.1 cm×6.3 cm right paracardial mass and right-sided pleural effusion. Pleural fluid was HHV-8 positive. The patient was diagnosed with PEL with extracavitary involvement and treated with chemotherapy and concurrent HAART. This case is the first reported case of extracavitary paracardial involvement and adds new insight to the accepted treatment for PEL with extracavitary lesions.
Department of Internal Medicine, Broward Health Medical Center, Fort Lauderdale, Florida, USA.
Heather
H
Katz
Department of Internal Medicine, Broward Health Medical Center, Fort Lauderdale, Florida, USA.
Cielo
C
Rose
Department of Internal Medicine, Broward Health Medical Center, Fort Lauderdale, Florida, USA.
Nina Thakker
NT
Rivera
Department of Internal Medicine, Broward Health Medical Center, Fort Lauderdale, Florida, USA.
Natasha
N
Bray
D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D003287:Contrast Media; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D054685:Lymphoma, Primary Effusion / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D013899:Thoracic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D003287:Contrast Media