Clinical proteomics and breast cancer.
BACKGROUND
Breast cancer is a heterogeneous disease. Yet, many molecular players and mechanisms behind the complexity of its clinical behaviour remain unknown, and advances in biomedical research are expected to unravel novel molecular discoveries in breast and other cancers. Clinical proteomics is currently experiencing rapid advances in technology that promise new means to improve breast cancer early diagnosis, stratification, and treatment response.


METHODS
We reviewed recent literature adopting clinical proteomics in breast cancer research.


RESULTS
This review highlights the principles, advantages, limitations, discoveries and future prospects of recent clinical proteomics discovery efforts in breast cancer research.


CONCLUSIONS
Numerous proteomic studies of breast cancer have been accomplished aiming to aid the development of personalised therapies, increase understanding of post treatment relapse, and help improve prediction of patient prognosis. This has led to the possible identification of profiles refining breast cancer subtypes and the discovery of novel biomarkers pointing towards diagnostic and prognostic potential.
Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Foundation Trust, Southampton, SO16 6YD, UK.
Bashar A
BA
Zeidan
Faculty Institute for Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Oxford Road, Manchester, M13 9WL, UK.
Paul A
PA
Townsend
Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Foundation Trust, Southampton, SO16 6YD, UK.
Spiros D
SD
Garbis
Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Foundation Trust, Southampton, SO16 6YD, UK.
Ellen
E
Copson
Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Foundation Trust, Southampton, SO16 6YD, UK. Electronic address: r.i.cutress@soton.ac.uk.
Ramsey I
RI
Cutress
D014408:Biomarkers, Tumor / Q000378:metabolism*; D035843:Biomedical Research / Q000379:methods*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D011379:Prognosis; D040901:Proteomics / Q000379:methods*
D014408:Biomarkers, Tumor
Biomarkers; Breast cancer; Mass spectrometry; Proteomics; Review