Primary gastrointestinal stromal tumor of the liver treated with sequential therapy.
A 67-year-old female presented with a primary hepatic gastrointestinal stromal tumor that was detected by computed tomography and diagnosed based on histopathological and genetic analyses. The tumor was microscopically composed of spindle cells and epithelioid cells, and immunohistochemistry results showed positive staining for CD117 and CD34 expression. A genetic analysis revealed a heterozygous point mutation and deletion in exon 11 of c-KIT. After an R0 resection, imatinib mesylate was administered for 1 year until its use was discontinued due to severe side effects. Two years after the original operation, the tumor recurred in the residual liver and was completely resected again. Imatinib mesylate was administered for 2 years until it was replaced by sunitinib malate because of disease progression. The patient has survived for 53 mo after undergoing a sequential therapy consisting of surgical excision, imatinib and sunitinib.
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Xian-Ke
XK
Lin
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Qing
Q
Zhang
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Wei-Li
WL
Yang
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Chun-Hui
CH
Shou
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Xiao-Sun
XS
Liu
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Jian-Yi
JY
Sun
Xian-Ke Lin, Qing Zhang, Wei-Li Yang, Chun-Hui Shou, Xiao-Sun Liu, Jian-Yi Sun, Ji-Ren Yu, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Ji-Ren
JR
Yu
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001549:Benzamides / Q000008:administration & dosage* / Q000009:adverse effects; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D004252:DNA Mutational Analysis; D057915:Drug Substitution; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D007211:Indoles / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D009154:Mutation; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects; D011758:Pyrroles / Q000008:administration & dosage*; D000077210:Sunitinib; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D014408:Biomarkers, Tumor; D007211:Indoles; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D000068877:Imatinib Mesylate; D000077210:Sunitinib
Diagnosis and treatment; Gastrointestinal stromal tumor; Liver; Sequential therapy; Tyrosine kinase inhibitor