Sequence variants on chromosome 9p21 are associated with ischemic stroke and the lipids level in Chinese Han population.
BACKGROUND
Several studies have demonstrated that variants on chromosome 9p21 confer susceptibility to ischemic stroke (IS) disease. But, the results of variants' roles in Chinese IS population are blank or inconsistent.


METHODS
We performed a case-control analysis in 116 patients with IS and 118 non-IS controls of Han background to determine whether 4 single nucleotide polymorphisms were associated with IS. DNA was extracted from saliva using a magnetic nanoparticles-based method.


RESULTS
After we adjusted for clinical parameters, we found that the rs10757278-GG genotype conveyed 1.88-fold (95% confidence interval [CI], 1.1-3.1; P = .015), the rs1537378-C allele conveyed 2.0-fold (95% CI, 1.2-3.5; P = .008), and the rs1333047-TT genotype conveyed 1.64-fold (95% CI, 1.02-2.6; P = .041) increased risk of IS, respectively. In addition, there is a significant difference of the lipids level between GG genotype compared with that of AA genotype in rs10757278 (P < .05).


CONCLUSIONS
This study is the first one to demonstrate that the rs10757278-GG genotype, the rs1537378-C allele, and rs1333047-TT genotype are associated with IS in Chinese Han populations. More importantly, the variant of rs10757278 may have different degrees of influence on lipids level.
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Jiajia
J
Bi
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Lin
L
Yang
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Dan
D
Liu
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Jun
J
Wu
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Xiaoxin
X
Tong
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Shuangshuang
S
Cen
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Da
D
Zhou
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Ting
T
Zhang
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China. Electronic address: yilitj@hotmail.com.
Li
L
Yi
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology / Q000208:ethnology; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012463:Saliva / Q000378:metabolism; D020521:Stroke / Q000208:ethnology / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*
Chromosome 9p21; genotype; liquid disturbances; saliva; sequence variation; stroke