Comparison of a three-in-one total nutrient mixture with conventional peripheral parenteral nutrition in children.
BACKGROUND
The aim of this study was to compare clinical aspects of the application of three-in-one total nutrient mixture (TNA) for peripheral parenteral nutrition (PPN) with those of the conventional PPN (cPPN) method of providing short-term parenteral nutrition for pediatric inpatients.


METHODS
We conducted a retrospective study in children from 2 to 18 years old who were hospitalized and underwent PPN administration. We compared clinical aspects of two methods of PPN, cPPN (n=39) and TNA (n=57).


RESULTS
The mean age was 6.5±3.1 years in the cPPN group and 8.2±3.4years in the TNA group (p=0.015). In the TNA group, there was a significantly shorter period between the day of admission and the first day of PPN or oral feeding (p<0.0001 & p<0.0001, respectively).The TNA group also fasted for a shorter period before PN after admission, and the total duration of fasting was also shorter (p<0.0001 & p<0.0001, respectively). The TNA group showed a lower glucose infusion rate and fewer daily administered total calories per weight (p<0.0001 & p=0.001, respectively). However, there was no significant difference in the amount of administered amino acids and lipids (p=0.584 & p=0.650, respectively) and PPN-related complications.


CONCLUSIONS
When providing nutrients to hospitalized children who cannot take in enough nutrients via the enteral route, TNA formula may be an easier and faster method than cPPN.
Department of Pediatrics, Chung-Ang University Hospital, Seoul, Korea.
Dae Yong
DY
Yi
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Seoul National University Bundang Hospital, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Republic of Korea. Email: hryang@snubh.org.|3Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
Hye Ran
HR
Yang
D000293:Adolescent; D000596:Amino Acids / Q000008:administration & dosage; D002648:Child; D002673:Child, Hospitalized; D002675:Child, Preschool; D002149:Energy Intake; D005215:Fasting; D005260:Female; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D008297:Male; D009753:Nutritive Value; D010288:Parenteral Nutrition / Q000379:methods*; D057947:Parenteral Nutrition Solutions; D012189:Retrospective Studies
D000596:Amino Acids; D008055:Lipids; D057947:Parenteral Nutrition Solutions