Voriconazole-responsive disseminated nodular lesions on spinal MRI.
A 74-year-old woman was hospitalized due to dysuria, weakness and dysesthesia of the lower extremities. She was in an immunosuppressed state following the administration of methylprednisolone therapy for idiopathic interstitial pneumonia. Cerebrospinal fluid and blood cultures were negative, and no infectious biomarkers were found. A gadolinium (Gd)-enhanced T1-weighted image of magnetic resonance imaging (MRI) revealed disseminated nodular lesions along the spinal cord. We suspected a diagnosis of seronegative deep mycosis and initiated anti-fungal therapy with voriconazole, which subsequently alleviated all of the patient's symptoms and MRI findings. Therefore, the presence of Gd-enhanced disseminated nodules on spinal MRI may be a good marker of deep meningeal mycosis.
Department of Neurology, Fujita Health University School of Medicine, Japan.
Seiko
S
Hirota
Shinji
S
Ito
Takao
T
Fukui
Kenichiro
K
Murate
Sayuri
S
Shima
Madoka
M
Kizawa
Akihiro
A
Ueda
Kunihiko
K
Asakura
Tatsuro
T
Mutoh
D000368:Aged; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D016921:Meningitis, Fungal / Q000175:diagnosis* / Q000188:drug therapy*; D008775:Methylprednisolone / Q000008:administration & dosage; D013116:Spinal Cord / Q000473:pathology*; D065819:Voriconazole / Q000627:therapeutic use*
D065819:Voriconazole; D019786:Gadolinium DTPA; D008775:Methylprednisolone