Quantitative assessment of the diagnostic role of CDH13 promoter methylation in lung cancer.
In order to explore the association between cadherin 13 (CDH13) gene promoter methylation and lung carcinoma (LC) risk, we carried out a meta-analysis with searching of PubMed, Web of Science. Ultimately, 17 articles were identified and analysised by STATA 12.0 software. Overall, we found a significant relationship between CDH13 promoter methylation and LC risk (odds ratio=6.98, 95% confidence interval: 4.21-11.56, p<0.001). Subgroup analyses further revealed that LC risk was increased for individuals carrying the methylated CDH13 compared with those with unmethylated CDH13. Hence, our study identified a strong association between CDH13 gene promoter methylation and LC and highlighted a promising potential for CDH13 methylation in LC risk prediction.
Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong Campus, Kunming, Yunnan, PR China E-mail : lingxi1995@outlook.com.
Yun-Hua
YH
Zhong
Hao
H
Peng
Hong-Zhong
HZ
Cheng
Ping
P
Wang
D015820:Cadherins / Q000235:genetics*; D019175:DNA Methylation; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D015201:Meta-Analysis as Topic; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*
D015820:Cadherins; C099972:H-cadherin