Exosomal communication goes viral.
Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA david.meckes@med.fsu.edu.
David G
DG
Meckes
D002450:Cell Communication / Q000502:physiology*; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D055354:Exosomes / Q000502:physiology* / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D008954:Models, Biological; D014763:Viral Matrix Proteins / Q000502:physiology
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins