Myc mouse and anti-ageing therapy.
Reduction in the expression and activity of a well-known proto-oncogene, Myc, has a beneficial effect on mouse health and survival to old age, in part independently of cancer impact, a recent study reveals. Is this new anti-ageing intervention pointing a way towards new treatments for age-related diseases?
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Nazif
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Alic
Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany. Electronic address: l.partridge@ucl.ac.uk.
Linda
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Partridge
D000375:Aging; D000818:Animals; D002908:Chronic Disease / Q000517:prevention & control*; D015536:Down-Regulation; D006304:Health Status; D006801:Humans; D051379:Mice; D008954:Models, Biological; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*
C000715470:MAS1 protein, human; C489427:MYC protein, human; C489428:Myc protein, mouse; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc