Image monitoring of pharmaceutical blending processes and the determination of an end point by using a portable near-infrared imaging device based on a polychromator-type near-infrared spectrometer with a high-speed and high-resolution photo diode array detector.
In the present study we have developed a new version (ND-NIRs) of a polychromator-type near-infrared (NIR) spectrometer with a high-resolution photo diode array detector, which we built before (D-NIRs). The new version has four 5 W halogen lamps compared with the three lamps for the older version. The new version also has a condenser lens with a shorter focal point length. The increase in the number of the lamps and the shortening of the focal point of the condenser lens realize high signal-to-noise ratio and high-speed NIR imaging measurement. By using the ND-NIRs we carried out the in-line monitoring of pharmaceutical blending and determined an end point of the blending process. Moreover, to determinate a more accurate end point, a NIR image of the blending sample was acquired by means of a portable NIR imaging device based on ND-NIRs. The imaging result has demonstrated that the mixing time of 8 min is enough for homogeneous mixing. In this way the present study has demonstrated that ND-NIRs and the imaging system based on a ND-NIRs hold considerable promise for process analysis.
Innovation Headquarters, Yokogawa Electric Corporation, 2-9-32 Nakacho, Musashino, Tokyo 180-8750, Japan. Koudai.Murayama@jp.yokogawa.com.
Kodai
K
Murayama
Graduate School of Agricultural Science, Tohoku University, 1-1 Amamiya, Tsutsumidori, Aobaku, Sendai 981-8555, Japan. daitaroishikawa@m.tohoku.ac.jp.|School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. daitaroishikawa@m.tohoku.ac.jp.
Daitaro
D
Ishikawa
School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. genkawa.takuma.fm@u.tsukuba.ac.jp.|Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan. genkawa.takuma.fm@u.tsukuba.ac.jp.
Takuma
T
Genkawa
Innovation Headquarters, Yokogawa Electric Corporation, 2-9-32 Nakacho, Musashino, Tokyo 180-8750, Japan. H.Sugino@jp.yokogawa.com.
Hiroyuki
H
Sugino
Innovation Headquarters, Yokogawa Electric Corporation, 2-9-32 Nakacho, Musashino, Tokyo 180-8750, Japan. Makoto.Komiyama@jp.yokogawa.com.
Makoto
M
Komiyama
School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. ozaki@kwansei.ac.jp.
Yukihiro
Y
Ozaki
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006219:Halogens / Q000737:chemistry; D059629:Signal-To-Noise Ratio; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods*
D006219:Halogens