Comparison of anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis.
BACKGROUND
The purpose of this prospective, randomized, double-blind, placebo-controlled study was to compare the anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve (IAN) blocks in patients with symptomatic irreversible pulpitis.


METHODS
One hundred patients with symptomatic irreversible pulpitis of mandibular posterior teeth were selected for the study. The patients received 1 mL magnesium sulfate USP 50% or distilled water (placebo) 1 hour before administration of conventional IAN block. Endodontic access cavity preparation was initiated 15 minutes after the IAN block injection. Lip numbness was recorded for all the patients. Success of IAN block was defined as no or mild pain on the visual analogue scale during access cavity preparation and initial instrumentation.


RESULTS
The success rate for the IAN block was 58% for magnesium sulfate group and 32% for the placebo group, with statistically significant difference between the 2 groups (P = .016).


CONCLUSIONS
In mandibular posterior teeth diagnosed with symptomatic irreversible pulpitis, preoperative administration of 1 mL magnesium sulfate USP 50% resulted in statistically significant increase in success of IAN block compared with placebo.
Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Karnataka, India. Electronic address: kprasad11@yahoo.com.
Krishna Prasad
KP
Shetty
Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Karnataka, India.
Sarvepalli Venkata
SV
Satish
Department of Restorative Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Krishna Rao
KR
Kilaru
Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Karnataka, India.
Poonam
P
Sardar
College of Dentistry, Ajman University of Science and Technology, Ajman, United Arab Emirates.
Alexander M
AM
Luke
D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008340:Mandibular Nerve; D009407:Nerve Block / Q000379:methods*; D011446:Prospective Studies; D011671:Pulpitis / Q000628:therapy*
D000779:Anesthetics, Local; D008278:Magnesium Sulfate; D008012:Lidocaine
Inferior alveolar nerve block; irreversible pulpitis; local anesthesia; magnesium sulfate