Design and optimization of self-nanoemulsifying formulations for lipophilic drugs.
The purpose of the current study was to develop and optimize novel self-nanoemulsifying drug delivery systems (SNEDDS) with a high proportion of essential oil as carriers for lipophilic drugs. Solubility and droplet size as a function of the composition were investigated, and a ternary phase diagram was constructed in order to identify the self-emulsification regions. The optimized SNEDDS formulation consisted of lemon essential oil (oil), Cremophor RH40 (surfactant) and Transcutol HP (co-surfactant) in the ratio 50:30:20 (v/v). Ibuprofen was chosen as the model drug. The droplet size, ζ-potential and stability of the drug-loaded optimized formulations were determined. The stability of SNEDDS was proved after triple freezing/thawing cycles and storage at 4 °C and 25 °C for 3 months. In vitro drug release studies of optimized SNEDDS revealed a significant increase of the drug release and release rate in comparison to the Ibuprofen suspension (80% versus approximately 40% in 2 h). The results indicated that these SNEDDS formulations could be used to improve the bioavailability of lipophilic drugs.
Department of Industrial Engineering and Biotech Research Centre, University of Trento, Italy.
Tianjing
T
Zhao
Devid
D
Maniglio
Jie
J
Chen
Bin
B
Chen
Antonella
A
Motta
Claudio
C
Migliaresi
D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000379:methods*; D065546:Drug Liberation; D004655:Emulsions / Q000737:chemistry*; D005026:Ethylene Glycols / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry*; D049329:Nanostructures / Q000627:therapeutic use*; D009822:Oils, Volatile / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
D004655:Emulsions; D005026:Ethylene Glycols; D009822:Oils, Volatile; C022131:cremophor; D011092:Polyethylene Glycols; C010111:carbitol; D007052:Ibuprofen