Heart failure in sinus rhythm: no routine antithrombotic therapy.
Several trials have compared aspirin or warfarin with either placebo or no antithrombotic drug therapy in a total of a few hundred patients with heart failure in sinus rhythm and no particular thrombotic risk.There is no evidence that antiplatelet or anticoagulant therapy reduces mortality or cardiovascular events, but antithrombotic drugs can provoke severe bleeding.
D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D061214:Patient Safety; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome; D019564:Unnecessary Procedures; D014859:Warfarin / Q000009:adverse effects / Q000627:therapeutic use*
D005343:Fibrinolytic Agents; D014859:Warfarin; D001241:Aspirin