Analysis of a mathematical model for tumor therapy with a fusogenic oncolytic virus.
Oncolytic virotherapy is a tumor treatment which uses viruses to selectively target and destroy cancer cells. Fusogenic viruses, capable of causing cell-to-cell fusion upon infection of a tumor cell, have shown promise in experimental studies. Fusion causes the formation of large, multinucleated syncytia which eventually leads to cell death. We formulate a partial differential equations model with a moving boundary to describe the treatment of a spherical tumor with a fusogenic oncolytic virus. Fusion, lysis, and budding are incorporated as mechanisms of viral spread, resulting in nonlocal integral terms. A proof is presented for existence and uniqueness of global solutions to the nonlinear hyperbolic-parabolic system. Numerical simulations demonstrate convergence to spatially homogeneous solutions and exponential growth or decay of the tumor radius depending on viral burst size and rate of fusion. Long-term tumor radius is shown to decrease with increasing values of viral burst size while the effect of the rate of fusion on tumor growth is demonstrated to be nonmonotonic.
Department of Mathematics, University of Florida, Gainesville, FL 32611, USA. Electronic address: jacobsen.50@mbi.osu.edu.
Karly
K
Jacobsen
Department of Mathematics, University of Florida, Gainesville, FL 32611, USA. Electronic address: pilyugin@ufl.edu.
Sergei S
SS
Pilyugin
D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000628:therapy*; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses
Free boundary problem; Hyperbolic–parabolic system; Oncolytic virus; Syncytia; Tumor