The impact of thyroid hormone replacement therapy on left ventricular diastolic function in patients with subclinical hypothyroidism.
OBJECTIVE
Subclinical hypothyroidism (SH) is associated with a moderately elevated risk of heart failure events among older adults. The objective of our prospective study was to assess the impact of thyroid hormone replacement therapy (HRT) with low doses of L-thyroxine (6.25-25 µg/day) on left ventricular diastolic function in patients with SH.


METHODS
33 patients with SH and 25 healthy controls were involved. All participants underwent standard echocardiography and Doppler imaging at baseline and, the patient group, also after a course of HRT.


RESULTS
At baseline, patients with SH showed significantly lower E (0.79 ± 0.22 vs. 0.93 ± 0.19, p < 0.001), E/A ratio (1.19 ± 0.29 vs. 1.31 ± 0.25, p < 0.003), and higher intraventricular septum thickness (IVST) (0.99 ± 0.14 vs. 0.89 ± 0.18, p < 0.001) in comparison with healthy controls. After 6 months of therapy, the E/A ratio underwent significant increase (1.28 ± 0.21 vs. 1.19 ± 0.29, p < 0.001), while the IVS displayed a robust reduction (0.92 ± 0.16 vs. 0.99 ± 0.14, p < 0.001).


CONCLUSIONS
HRT with low-dosed L-thyroxine may improve left ventricular diastolic function in patients with SH.
Lviv National Medical University, Lviv, Ukraine.
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Shatynska-Mytsyk
Central University Hospital of Asturias (HUCA), Oviedo, Asturias, Spain.
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Rodrigo
Clinica Medica I, Fondazione IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Pavia, Italy.
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Cioccocioppo
Institute of Histology and Embryology, University of Ljubljana, Ljubljana, Slovenia.
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Petrovic
Department of Cardiology, Hospital for Medical Rehabilitation, Krapinske Toplice, Croatia.|Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia.
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Lakusic
Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
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Compostella
International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic.
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Novak
International Clinical Research Center, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic. peter.kruzliak@savba.sk.
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Kruzliak
D000328:Adult; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013974:Thyroxine / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*; D016277:Ventricular Function, Left / Q000187:drug effects
D013974:Thyroxine
Echocardiography; Heart failure; Left ventricular diastolic function; Subclinical hypothyroidism