Impact of gelation period on modified locust bean-alginate interpenetrating beads for oral glipizide delivery.
In this work, the effect of hydrogelation period in the design of glipizide-loaded biopolymer-based interpenetrating network (IPN) beads was investigated. Carboxymethyl locust bean gum and sodium alginate IPN beads were prepared by ionic crosslinking method using aqueous aluminium chloride salt solution as gelation medium. The longer exposure of the IPN beads in the gelation medium caused a considerable loss of the drug (∼ 8%), and also affected their surface morphology and drug release performance. Spherical shape of the IPN beads was observed under scanning electron microscope (SEM). The diameter of IPN beads increased with increasing gelation time. The IPNs cured for 0.5h exhibited slower drug release kinetics in HCl (pH 1.2) and phosphate buffer (pH 7.4) solution than those incubated for 1-2h. The drug release occurred at a faster rate in phosphate buffer solution and continued for a minimum period of 8h. The IPNs cured for the lowest period obeyed polymer chain-relaxation phenomenon as dominating mechanism for drug release. However, all the IPNs followed anomalous mechanism of drug transport. The drug release corroborated well with pH-dependent swelling behaviors of the IPNs. Thus, IPN beads cured for 0.5h were found most suitable for controlled delivery of BCS class II anti-diabetic drug glipizide.
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: paramita.dey6@gmail.com.
Paramita
P
Dey
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Biswanath
B
Sa
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol 713301, West Bengal, India.
Sabyasachi
S
Maiti
D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005913:Glipizide / Q000008:administration & dosage* / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006110:Grasshoppers / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry; D008863:Microspheres; D011108:Polymers / Q000737:chemistry
D000464:Alginates; D004337:Drug Carriers; D006603:Hexuronic Acids; D011108:Polymers; D020723:Glucuronic Acid; D005913:Glipizide
Carboxymethyl locust bean gum; Drug release kinetics; Hydrogelation; Interpenetrating network; Ionic crosslinking method; Sodium alginate