MWNT-hybrided supramolecular hydrogel for hydrophobic camptothecin delivery.
To encapsulate the hydrophobic camptothecin (CPT) into hydrogel matrix with a high loading amount, a supramolecular hydrogel hybrided with multi-walled carbon nanotubes (MWNTs) was developed by the host-guest interactions and used for loading and delivering CPT. Firstly, carboxylated MWNTs were modified by polyethylene glycol monomethyl ether (MPEG), which resulted in the water-dispersed MPEG-MWNTs. Then α-cyclodextrin (α-CD) was mixed with MPEG-MWNTs and the hybrid supramolecular hydrogel was fabricated by the inclusion interactions between α-CD and MPEG. The used MPEG not only dispersed MWNTs in aqueous solution, but also functioned as hydrogel matrix by interacting with α-CD. The gelation time for the sol-gel transition and rheological properties of the resultant hydrogels were studied. Due to the excellent application of MWNTs in drug delivery, hydrophobic CPT could be loaded into the hydrogel matrix by a higher amount compared with micelles. By in vitro release and cell viability tests, it was found that the encapsulated CPT could exhibit a controlled and sustained release behavior as well as sustained antitumor efficacy.
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
Shansong
S
Mu
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China; College of chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
Yuanyuan
Y
Liang
Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Shuaijun
S
Chen
Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: ceszhlm@mail.sysu.edu.cn.
Liming
L
Zhang
Department of Otolaryngology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Electronic address: liutao_smu@163.com.
Tao
T
Liu
D002166:Camptothecin / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D055119:Elastic Modulus / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013997:Time Factors; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry
D037742:Nanotubes, Carbon; D047391:alpha-Cyclodextrins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol; D002166:Camptothecin; C032613:alpha-cyclodextrin
Camptothecin; Carbon nanotube; High loading; Supramolecular hydrogel; Sustained release