Bionanotechnology and the future of glioma.
Designer nanoscaled materials have the potential to revolutionize diagnosis and treatment for glioma. This review summarizes current progress in nanoparticle-based therapies for glioma treatment including targeting, drug delivery, gene delivery, and direct tumor ablation. Preclinical and current human clinical trials are discussed. Although progress in the field has been significant over the past decade, many successful strategies demonstrated in the laboratory have yet to be implemented in human clinical trials. Looking forward, we provide examples of combined treatment strategies, which harness the potential for nanoparticles to interact with their biochemical environment, and simultaneously with externally applied photons or magnetic fields. We present our notion of the "ideal" nanoparticle for glioma, a concept that may soon be realized.
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
Peter A
PA
Chiarelli
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
Forrest M
FM
Kievit
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA ; Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, USA.
Miqin
M
Zhang
Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.
Richard G
RG
Ellenbogen
Drug delivery; glioblastoma multiforme; nanomedicine; nanoparticle; nanotechnology; theranostic