Pharmacokinetic/pharmacodynamic evaluation of eslicarbazepine for the treatment of epilepsy.
BACKGROUND
Eslicarbazepine acetate (ESL) is a novel antiepileptic drug registered as the adjunctive treatment of partial-onset seizures in adults. As a third-generation medication, ESL is believed to have favorable efficacy/safety profile and pharmacokinetic properties in comparison with related drugs (carbamazepine and oxcarbazepine).


METHODS
The aim of the paper was to evaluate pharmacodynamic and pharmacokinetic properties of ESL with aspect to epilepsy treatment. The review of the scientific literature was based on the PubMed database, Clinical Trials, FDA and European Medicines Agency websites to elicit current information on drug metabolism, mechanism of action and efficacy/safety profile.


CONCLUSIONS
Results of clinical trials indicate that ESL possessed a favorable profile of anticonvulsant efficacy and tolerability as an add-on therapy in adult patients at daily doses of 800 and 1200 mg. Pediatric trials are in progress and their results will allow to characterize a role of ESL in the treatment of epilepsy in children.
Medical University of Lublin, Department of Pathophysiology , Jaczewskiego 8, PL-20-090 Lublin , Poland +48 81 718 7365 ; +48 81 718 7364 ; czuczwarsj@yahoo.com.
Monika
M
Banach
Kinga K
KK
Borowicz
Stanisław J
SJ
Czuczwar
D000328:Adult; D000367:Age Factors; D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000627:therapeutic use; D002648:Child; D003984:Dibenzazepines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D000078330:Oxcarbazepine
D000927:Anticonvulsants; D003984:Dibenzazepines; D002220:Carbamazepine; C416835:eslicarbazepine acetate; D000078330:Oxcarbazepine
epilepsy; eslicarbazepine; eslicarbazepine acetate; partial seizures