Expression of glypican-3 is highly associated with pediatric hepatoblastoma: a systemic analysis.
OBJECTIVE
Glypican-3 (GPC3) is reported to be an oncofetal protein that is a useful diagnostic immunomarker for hepatoblastoma. However, the results are not inclusive. This study systemically investigated the association between expression of GPC3 and pediatric hepatoblastoma.


METHODS
Clinical studies evaluating the association were identified using a predefined search strategy. GPC3 immunohistochemistry was applied in the pathological diagnosis of hepatoblastoma using the monoclonal antibodies with formalin-fixed and paraffin-embedded specimens. Positive predictive rates for the association between expression of GPC3 and pediatric hepatoblastoma were calculated.


RESULTS
Specimens from four clinical studies which including 134 patients with pediatric hepatoblastoma tested by GPC3 immunohistochemistry were considered eligible for inclusion. Systemic analysis showed that, in all patients, pooled positive predictive rate of the association between expression of GPC3 and pediatric hepatoblastoma was 95.5% (128/134).


CONCLUSIONS
This systemic analysis suggests that the expression of glypican-3 is highly associated with the diagnosis of pediatric hepatoblastoma.
Dept. of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China E-mail : zhwa0675@aliyun.com.
Xiao-Li
XL
Xiong
Huan
H
Qin
Su-Qi
SQ
Yan
Li-Shan
LS
Zhou
Peng
P
Chen
Dong- Chi
D
Zhao
D000911:Antibodies, Monoclonal / Q000276:immunology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002648:Child; D005500:Follow-Up Studies; D053673:Glypicans / Q000276:immunology / Q000378:metabolism*; D018197:Hepatoblastoma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; C105937:GPC3 protein, human; D053673:Glypicans