High-grade astrocytoma (Glioblastoma Multiforme) in an Atlantic spotted dolphin (Stenella frontalis).
This report describes the gross, microscopical and immunohistochemical features of a high-grade astrocytoma (glioblastoma multiforme) in an adult male Atlantic spotted dolphin (Stenella frontalis). On necropsy examination, a 5 × 2.5 × 2 cm, poorly demarcated, red, friable and locally expansile mass effaced the thalamus and the left periventricular region and extended to the left lateral ventricle of the brain. Microscopically, the mass consisted of haphazardly arranged bundles and rows of interweaving polygonal to spindle-shaped cells. These often palisaded along serpentine foci of necrosis and were surrounded by prominent vessels. Immunohistochemically, the neoplastic cells expressed glial fibrillary acidic protein, but not vimentin, S100 protein, neuron-specific enolase or neurofilament protein. A diagnosis of high-grade astrocytoma was made and this represents the first description of a glioma in a cetacean species.
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain. Electronic address: josue.diaz101@estudiantes.ulpgc.es.
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Díaz-Delgado
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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Sacchini
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
A
A
Suárez-Bonnet
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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E
Sierra
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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Arbelo
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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A
Espinosa
Division of Oncology and Comparative Surgery, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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E
Rodríguez-Grau Bassas
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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B
Mompeo
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
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L
Pérez
Division of Histology and Animal Pathology, Department of Morphology, Institute for Animal Health, University of Las Palmas de Gran Canaria, Canary Islands, Spain.
A
A
Fernández
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology / Q000662:veterinary*; D005909:Glioblastoma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D008297:Male; D060787:Neoplasm Grading; D050706:Stenella
D014408:Biomarkers, Tumor
Atlantic spotted dolphin; astrocytoma; brain; immunohistochemistry