The value of the urinary protein:creatinine ratio for the detection of significant proteinuria in women with suspected preeclampsia.
To explore the correlation between urinary protein:creatinine ratio and 24-h excretion of protein, we studied 149 women referred to a day assessment unit for investigations for suspected preeclampsia. Paired samples were obtained for measurement of urinary protein:creatinine ratio and 24-h protein excretion. Collection of a 24-h urine sample was validated by the daily creatinine excretion. The outcome measure was proteinuria of 300 mg/day or more. Inaccurate 24-h collection was observed in 17% of women. All women (n = 56) with a protein:creatinine ratio >60 mg/mM had significant proteinuria. No woman with protein:creatinine ratio <18 mg/mM (n = 20) had significant proteinuria. We recommend that a dual cut-off should be used for excluding and "ruling in" the diagnosis of significant proteinuria. A 24-h urine collection should be used only for urinary protein:creatinine ratio values between 18 and 60 mg/mM in the detection of significant proteinuria.
Fetal Assessment Unit, St George's Hospital, London, UK.
Amar
A
Bhide
Ritu
R
Rana
Mrugaya
M
Dhavilkar
Montserrat
M
Amodio-Hernandez
Deepika
D
Deshpande
Vedrana
V
Caric
D000328:Adult; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000209:etiology / Q000652:urine*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011507:Proteinuria / Q000150:complications / Q000175:diagnosis* / Q000652:urine*; D012372:ROC Curve; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult
D003404:Creatinine
Creatinine; hypertensive disorders; preeclampsia; protein-creatinine ratio; proteinuria