A convenient method for palladium-catalyzed reductive deuteration of organic substrates using deuterated hypophosphite in D2O.
A convenient method for the deuteration of organic substrates using deuterated hypophosphite as the deuterium source was investigated. Transfer deuteration of organic substrates, such as aromatic halides, alkenes, alkynes, epoxides, and O-benzyl derivatives, in the presence of palladium on carbon in deuterium oxide proceeded efficiently to give the corresponding deuterated products in excellent yields with high deuterium contents.
Tokai University, Liberal Arts Education Center, Shimizu Campus, 3-20-1 Orido, Shimizu-ku, Shizuoka, 424-8610, Japan.
Makoto
M
Oba
D002384:Catalysis; D017666:Deuterium Oxide / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010721:Phosphinic Acids / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
D009930:Organic Chemicals; D010721:Phosphinic Acids; D019275:Radiopharmaceuticals; D010165:Palladium; D017666:Deuterium Oxide
deuterated hypophosphite; deuterium oxide; palladium catalyst; transfer deuteration