Hemichorea in a diabetes mellitus patient following acute ischemic stroke with changes in regional cerebral blood flow.
It is not unusual to observe hemichorea in patients with diabetes mellitus, with origins attributable to recent ischemia. Our patient was a 66-year-old female with diabetes mellitus who suddenly developed right hemichorea, mild muscle weakness of the right upper extremity, ideational apraxia, and acalculia. Her blood glucose was 600 mg/dL, and HbA1c was 13.3%. After the patient underwent head magnetic resonance imaging (MRI), a new cerebral infarction was observed in the left frontal lobe, and treatment was started with edaravone and cilostazol. At the same time, insulin treatment was also started for hyperglycemia. The acalculia and ideational apraxia improved approximately 1 week after treatment initiated, and the hemichorea also decreased. ECD-SPECT was performed on admission, and it was observed that blood flow was decreased in the left frontal lobe and striatum, but increased in the thalamus; two weeks later on follow-up ECD-SPECT, blood flow had increased slightly in the left forebrain and striatum, while it had decreased slightly in the thalamus. This suggests that the cause of hemichorea was related to ischemia. When the activity of the pallidum is impaired, it is presumed that the inhibitory activity towards the thalamus weakens and the thalamic cells become over-excited, causing chorea.
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan. Electronic address: suzuki.yutaka@nihon-u.ac.jp.
Yutaka
Y
Suzuki
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Minoru
M
Oishi
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Akira
A
Kanno
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Katsuhiko
K
Ogawa
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Mariko
M
Fujisawa
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Satoshi
S
Kamei
D000368:Aged; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D002819:Chorea / Q000000981:diagnostic imaging / Q000209:etiology*; D048909:Diabetes Complications / Q000209:etiology*; D005260:Female; D006801:Humans; D020521:Stroke / Q000150:complications* / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon
ECD-SPECT; cerebral infarction; diabetes mellitus; hemichorea; regional cerebral blood flow