High doses of onabotulinumtoxinA in post-stroke spasticity: a retrospective analysis.
We retrospectively evaluated the efficacy and safety of high doses of onabotulinumtoxinA (from 600 to 800 units) in 26 patients affected by upper and/or lower limb post-stroke spasticity. They were assessed before, 30 and 90 days after treatment. We observed a significant muscle tone reduction and a significant functional improvement (assessed with the Disability Assessment Scale). No adverse events were reported. In our retrospective analysis the treatment with high doses of onabotulinumtoxinA showed to be effective and safe.
Physical and Rehabilitative Medicine - University Hospital "Maggiore della Carità", Novara, Italy, alessio.baricich@maggioreosp.novara.it.
Alessio
A
Baricich
Elisa
E
Grana
Stefano
S
Carda
Andrea
A
Santamato
Carlo
C
Cisari
Marco
M
Invernizzi
D001132:Arm / Q000503:physiopathology; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007866:Leg / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D012189:Retrospective Studies; D020521:Stroke / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors; D016896:Treatment Outcome
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A