Validation of noninvasive hemoglobin measurement by pulse co-oximeter in newborn infants.
OBJECTIVE
To describe the accuracy of noninvasive hemoglobin (Hb) obtained with pulse co-oximeter (SpHb) compared with total Hb (tHb) from laboratory co-oximeter in neonates.


METHODS
Neonates with birth weight (BW) <3000 g admitted to LAC+USC Medical Center neonatal intensive care unit were included. SpHb was recorded using Masimo Radical-7 and compared with tHb. A total of three data sets were obtained for each patient. Regression analysis and Bland-Altman analysis were performed.


RESULTS
Sixty-one patients (mean±s.d., BW 1177±610 g and gestational age 28.7±3.9 weeks) were enrolled. The mean tHb value was 13.9±2.0 g dl(-1) and the mean SpHb was 14.0±2.0 g dl(-1). There was a moderately positive correlation between SpHb and tHb (r=0.66, P<0.001) with a bias and precision of -0.09±1.67 g dl(-1). Data from a subgroup of infants with gestational age ⩽32 weeks (52/61 patients) were analyzed, and the correlation coefficient was moderately positive (r=0.69, P<0.001) with a bias and precision of -0.23±1.60 g dl(-1).


CONCLUSIONS
Our results suggest that noninvasive SpHb may be considered as an adjunct to invasive tHb measurements in newborn infants <3000 g especially in preterm infants ⩽32 weeks of gestation.
1] Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA [2] Division of Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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Nicholas
Division of Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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George
Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA.
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Sardesai
Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA.
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Durand
1] Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA [2] Division of Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
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Ramanathan
Division of Neonatal Medicine, Department of Pediatrics, LAC+USC Medical Center, University of Southern California, Los Angeles, CA, USA.
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Cayabyab
D015982:Bias; D005260:Female; D006452:Hemoglobinometry / Q000295:instrumentation*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007223:Infant; D062071:Infant, Extremely Premature / Q000097:blood*; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D008297:Male; D010092:Oximetry / Q000379:methods*; D011446:Prospective Studies; D012044:Regression Analysis
D006454:Hemoglobins