Synthesis, characterization, X-ray crystal structure, DFT calculation, DNA binding, and antimicrobial assays of two new mixed-ligand copper(II) complexes.
Two new Cu(II) complexes, [Cu(L)(phen)] (1), [Cu(L)(bipy)] (2), where L(2-)=(3-methoxy-2oxidobenzylidene)benzohydrazidato, phen=1,10 phenanthroline, and bipy=2,2' bipyridine, were prepared and fully characterized using elemental analyses, FT-IR, molar conductivity, and electronic spectra. The structures of both complexes were also determined by X-ray diffraction. It was found that, both complexes possessed square pyramidal coordination environment in which, Cu(II) ions were coordinated by donor atoms of HL and two nitrogens of heterocyclic bases. Computational studies were performed using DFT calculations at B3LYP/6-311+G(d,p) level of theory. DNA binding activities of these complexes were also investigated using electronic absorption, competitive fluorescence titration and cyclic voltammetry studies. The obtained results indicated that binding of the complexes to DNA was of intercalative mode. Furthermore, antimicrobial activities of these compounds were screened against microorganisms.
Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address: Ebrahimipour@uk.ac.ir.
S Yousef
SY
Ebrahimipour
Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.
Iran
I
Sheikhshoaie
Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran; Department of Chemistry, Payame Noor University (PNU), 19395-4697 Tehran, Iran.
Maryam
M
Mohamadi
Departamento de Química Inorgínica, Analítica y Química, Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
Sebastian
S
Suarez
Gerencia de Investigación y Aplicaciones, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Buenos Aires, Argentina.
Ricardo
R
Baggio
Department of Biology, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.
Moj
M
Khaleghi
Department of Biotechnology, Institute of Science, High Technology and Environmental Science, Graduate University of Advance Technology, Kerman, Iran.
Masoud
M
Torkzadeh-Mahani
Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran.
Ali
A
Mostafavi
D015082:2,2'-Dipyridyl / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology; D012474:Salmon
D000890:Anti-Infective Agents; D056831:Coordination Complexes; D007364:Intercalating Agents; D010618:Phenanthrolines; D015082:2,2'-Dipyridyl; D003300:Copper; D004247:DNA
Antimicrobial activity; Crystal structure; Cu(II) complex; DFT calculation; DNA binding; Hydrazone Schiff base