[Regeneration and fibrosis of corneal tissues].
In this review, the features of the regeneration of corneal tissue and its disorders leading to the development of fibrosis are considered. The data on the presence of stem (clonogenic) cell pool in the corneal tissues (epithelium, endothelium, stroma) are given; these cells can serve as a source for regeneration of the tissues at injury or various diseases. The main steps of regeneration of corneal tissues and their disorders that lead to outstripping proliferation of myofibroblasts and secretion of extracellular matrix in the wound area and eventually cause the formation of connective tissue scar and corneal opacity are considered. Particular attention is given to the successes of translational medicine in the treatment of corneal tissue fibrosis. The methods of cell therapy aimed at the restoration of stem cell pool of corneal tissues are the most promising. Gene therapy provides more opportunities; one of its main objectives is the suppression of the myofibroblast proliferation responsible for the development of fibrosis.
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Simirskiĭ
D003315:Cornea / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D003316:Corneal Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019573:Epithelium, Corneal / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D005355:Fibrosis; D015316:Genetic Therapy; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D015398:Signal Transduction