Minimal inhibitory concentration drift of glycopeptides and linezolid against S. Aureus at a Chinese children's center, 2009-2013.
We analyzed the drift in the minimum inhibitory concentration (MIC) of glycopeptides and linezolid against 793 methicillin-resistant Staphylococcus aureus (MRSA) and 4696 methicillin-susceptible S. aureus (MSSA) isolates from Chinese children. For vancomycin and teicoplanin, no significant change occurred in different years for MIC values ≥ 2 μg/mL, either in MRSA or MSSA. For linezolid, there was an MIC drift in MRSA and in MSSA.
From the *Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; †Key Laboratory of Pediatrics in Chongqing; and ‡Chonging International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
Chun-Mei
CM
Jing
Wei
W
Xie
Yuan
Y
Chen
Cai
C
Wang
D000081:Acetamides / Q000494:pharmacology*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002681:China; D024881:Drug Resistance, Bacterial; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D014640:Vancomycin; D000069349:Linezolid