[Clinical significance of miRNA-204 in nasopharyngeal carcinoma].
OBJECTIVE
To investigate the expression of miRNA-204 in patients with NPC and to analyze the as- sociation of the expression with the cIinicopathologicaI features and prognosis.


METHODS
The expression levels of miRNA-204 in 50 patients with NPC and 40 patients with nasopharyngeal chronic inflammation were detected by using stem-loop real-time reverse transcription-polymerase chain reaction RT-PCR. Analysis of the relationship between microRNA and prognosis by Kaplan-Meier method.


RESULTS
Expression levels of miRNA-204 were down- regulated in patients with NPC as compared with patients with nasopharyngeal chronic inflammation (P < 0.05). The expression of miRNA-204 was associated with EBV infection, differentiation, lymphatic metastasis and TNM stages (P < 0.05). Low miRNA-204 expression was significantly correlated with shorter overall survival (P < 0.05) of NPC.


CONCLUSIONS
The downregulation of miRNA-204 expression has related with disease progression and miRNA-204 can serve as a potential therapeutic target for NPC.
Tao
T
Peng
Xuhong
X
Zhou
Min
M
Hu
Tingting
T
Wu
D002277:Carcinoma; D018450:Disease Progression; D015536:Down-Regulation; D006801:Humans; D008207:Lymphatic Metastasis; D035683:MicroRNAs / Q000378:metabolism*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D009305:Nasopharynx; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction
C549404:MIRN204 microRNA, human; D035683:MicroRNAs