Pathologic correlates of late gadolinium enhancement cardiovascular magnetic resonance in a heart transplant patient.
We report the histopathologic correlates of late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) in a patient with heart transplant who died for graft failure a few months after the scan. Extensive late enhancement was present at CMR, and it correlated with extensive fibrosis at histology. To our knowledge, this is the first time the findings on contrast enhancement CMR are compared to the histology of the whole heart in a heart transplantation patient, and the correspondence between LGE and fibrosis, demonstrated in other cardiac pathologies, is confirmed also in this particular setting.
Department of Cardiology, Cardiovascular Magnetic Resonance Unit, Niguarda Cà Granda Hospital, Milano, Italy. Electronic address: patrizia.pedrotti@ospedaleniguarda.it.
Patrizia
P
Pedrotti
Pathology Laboratories, Niguarda Cà Granda Hospital, Milano, Italy.
Edgardo
E
Bonacina
Department of Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Claudia
C
Vittori
Department of Cardiology, Heart Transplant Unit, Niguarda Cà Granda Hospital, Milan, Italy.
Maria
M
Frigerio
Department of Cardiology, Cardiovascular Magnetic Resonance Unit, Niguarda Cà Granda Hospital, Milano, Italy.
Alberto
A
Roghi
D000328:Adult; D001344:Autopsy; D002423:Cause of Death; D003287:Contrast Media; D017809:Fatal Outcome; D005355:Fibrosis; D019786:Gadolinium DTPA; D006084:Graft Rejection / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006323:Heart Arrest / Q000209:etiology / Q000473:pathology; D006331:Heart Diseases / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D006333:Heart Failure / Q000209:etiology / Q000473:pathology; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D003287:Contrast Media; D019786:Gadolinium DTPA
Cardiac magnetic resonance; Fibrosis; Heart transplant; Late enhancement