Bioinspired therapeutic dendrimers as efficient peptide drugs based on supramolecular interactions for tumor inhibition.
Bioinspired tryptophan-rich peptide dendrimers (TRPDs) are designed as a new type of dendritic peptide drugs for efficient tumor therapy. The TRPDs feature a precise molecular structure and excellent water solubility and are obtained in a facile process. Based on the unique features of peptide dendrimers, including highly branched structures, abundant terminal groups, and globular-protein-like architectures, the therapeutic dendrimers show significant supramolecular interactions with DNA through the tryptophan residues (indole rings and amino groups). Further experimental results indicate that TRPDs are efficient antitumor agents both in vitro and in vivo.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064 (P.R. China).
Xiao
X
Zhang
Zhijun
Z
Zhang
Xianghui
X
Xu
Yunkun
Y
Li
Yachao
Y
Li
Yeting
Y
Jian
Zhongwei
Z
Gu
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D050091:Dendrimers / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000188:drug therapy*; D010455:Peptides / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D050091:Dendrimers; D010455:Peptides
antitumor agents; dendrimers; peptide drugs; supramolecular chemistry; tryptophan