Development of a novel fluorapatite-forming calcium phosphate cement with calcium silicate: in vitro and in vivo characteristics.
Aim of this study was to develop a novel fluorapatite-forming calcium phosphate cement (FA-CPC) with tricalcium silicate (TCS) for endodontic applications and to examine its in vitro and in vivo characteristics. The FA-CPC powder consisted of 62.8% CaHPO4, 30.8% CaCO3, and 6.4% NaF. One part of TCS was combined with 9 parts of FA-CPC powder (FA-CPC with TCS). A 1.5 M phosphate solution was used as cement liquid. Setting time (ST), diametral tensile strength (DTS), phase composition by X-ray diffraction (XRD), and cement alkalinity were analyzed. Cement biocompatibility was assessed using rat subcutaneous model. Cement ST was 10.3±0.6 min and DTS was 3.89±0.76 MPa. XRD patterns showed that highly crystalline apatitic material was the only significant phase present and pH value was approximate 11.0. FA-CPC with TCS demonstrated similar biocompatibility as that of mineral trioxide aggregate control. These results suggest that FA-CPC with TCS may be useful for endodontic applications.
Department of Endodontics, Nihon University School of Dentistry.
Yusuke
Y
Suzuki
Makoto
M
Hayashi
Takuya
T
Yasukawa
Hiroshi
H
Kobayashi
Kosuke
K
Makino
Yoriyuki
Y
Hirano
Shozo
S
Takagi
Laurence C
LC
Chow
Bunnai
B
Ogiso
D000818:Animals; D001031:Apatites / Q000737:chemistry*; D001843:Bone Cements / Q000737:chemistry*; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D003738:Dental Cements; D008422:Materials Testing; D051381:Rats; D017640:Silicates / Q000737:chemistry*; D013718:Tensile Strength; D014961:X-Ray Diffraction
D001031:Apatites; D001843:Bone Cements; D017610:Calcium Compounds; D002130:Calcium Phosphates; D003738:Dental Cements; D017640:Silicates; C506393:tricalcium silicate; C020243:calcium phosphate; C025105:fluorapatite; C031293:calcium silicate