Exogenous natural glycoprotein multiple mechanisms of anti-tumor activity.
Natural glycoproteins can induce apoptosis of tumor cells and exert anti-tumor activity by immunomodulatory functions, cytotoxic and anti-inflammation effects, and inhibition of endothelial growth factor. Given their prospects as novel agents, sources of natural antitumor glycoproteins have attracted attention and new research directions in glycoprotein biology are gradually shifting to the direction of cancer treatment and prevention of neoplastic disease. In this review, we summarize the latest findings with regard to the tumor suppressor signature of glycoproteins and underlying regulatory mechanisms.
Harbin Commercial University Life Science and Environmental Science Research Center, Harbin, China E-mail : myths110@163.com.
Hong-Liang
HL
Yuan
Xiao-Lei
XL
Liu
Qi-Chang
QC
Dai
Hui
H
Song
D000818:Animals; D016147:Genes, Tumor Suppressor; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000517:prevention & control*
D006023:Glycoproteins