Effect of taurine on rat Achilles tendon healing.
Taurine has anti-inflammatory and antioxidant characteristics. We have introduced taurine into a tendon-healing model to evaluate its effects on tendon healing and adhesion formation. Two groups of 16 rats underwent diversion and repair of the Achilles tendon. One group received a taurine injection (200 mg/ml) at the repair site, while the other group received 1 ml of saline. Specimens were harvested at 6 weeks and underwent biomechanical and histological evaluation. No tendon ruptured. Average maximum load was significantly greater in the taurine-applied group compared with the control group (p < 0.05). Similarly, average energy uptake was significantly higher in the taurine-applied group compared with the control group (p < 0.05). We observed no significant differences in stiffness in both groups (p > 0.05). After histological assessment, we found that fibroblast proliferation, edema, and inflammation statistically decreased in the treatment group (p < 0.05). These findings could indicate greater tendon strength with less adhesion formation, and taurine may have an effect on adhesion formation.
Department of Plastic, Reconstructive, and Aesthetic Surgery, Kemerburgaz University , Istanbul , Turkey .
Ovunc
O
Akdemir
William C
WC
Lineaweaver
Turker
T
Cavusoglu
Erdal
E
Binboga
Yigit
Y
Uyanikgil
Feng
F
Zhang
Mahmut
M
Pekedis
Tugay
T
Yagci
D000125:Achilles Tendon / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*; D013708:Tendon Injuries / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D013654:Taurine
Antiadhesion; fibrosis; rats; taurine; tendon healing