Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.
A survivin siRNA expression vector was transfected into glioma U-87MG cells and these cells were then treated with paclitaxel. The results showed that survivin-specific siRNA combined with paclitaxel treatment synergistically inhibited glioma U-87MG cell proliferation and promoted apoptosis. This treatment also inhibited the expression of the cell cycle regulatory proteins, survivin, cyclinD1, c-Myc and CDK4 and enhanced the sensitivity of U-87MG cells to paclitaxel.
Department of Neurology, First Clinical Hospital of Bethune Medical College of Jilin University, Changchun 130001, Jilin Province, China ; Department of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.
Yunliang
Y
Xie
Department of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.
Yanbo
Y
Liu
Department of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.
Weigao
W
Shen
Department of Anatomy, Basic Medical College, Beihua University, Jilin 132013, Jilin Province, China.
Bo
B
Zhang
Department of Neurology, First Clinical Hospital of Bethune Medical College of Jilin University, Changchun 130001, Jilin Province, China.
Qun
Q
Liu
RNA interference; glioma; neural regeneration; paclitaxel; survivin