Abeliaside, a new phenolic glucoside from Abelia triflora.
A new phenolic glucoside, abeliaside, along with four known compounds, 5,6,7,4'-tetrahydroxy flavones, caffeic acid, 4-O-caffeoylquinic acid and caffeic acid glucoside, was isolated from the leaves of Abelia triflora R. Br. (Caprifoliaceae). The structure of the new compound was elucidated by different spectroscopic techniques. Compounds 1-5 were assayed for their anticancer activities against two cancerous human cell lines, MCF-7 and PC-3 cells, and normal Vero cell line using the crystal violet staining method. From the results it could be seen that caffeic acid possessed the highest anticancer effect against MCF-7 (IC50: 17 μg/mL) and PC-3 (IC50: 20.1 μg/mL) compared to vinblastine sulphate as reference drug (IC50: 4.6, 2.8 μg/mL). The other compounds showed weak anticancer activity on both cell lines.
a Department of Pharmacognosy , College of Pharmacy, King Saud University, Riyadh , PO Box 2457, Riyadh 11451 , Saudi Arabia.
Areej Mohammad
AM
Al-Taweel
Shagufta
S
Perveen
Ghada Ahmed
GA
Fawzy
Afsar
A
Khan
Rashad
R
Mehmood
Abdul
A
Malik
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification; D027922:Caprifoliaceae / Q000737:chemistry*; D002522:Chlorocebus aethiops; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification; D018515:Plant Leaves / Q000737:chemistry; D014709:Vero Cells
D000972:Antineoplastic Agents, Phytogenic; D002109:Caffeic Acids; D005960:Glucosides; D010636:Phenols; C000603257:abeliaside; C040048:caffeic acid
Abelia triflora; Caprifoliaceae; MCF-7 cells; PC-3 cells; phenolic glucosides