The impact of the CB2-63 polymorphism on the histological presentation of chronic hepatitis B.
The impact of the cannabinoid receptor 2 (CB2) rs35761398 polymorphism on chronic hepatitis B (CHB) was evaluated in 106 consecutive biopsy-proven CHB patients naive for antiviral therapy. A histological activity index (HAI) > 8 (Ishak scoring) was more frequent in patients with CB2-63 RR than in those with CB2-63 QR or QQ (37% vs. 16.7%, p < 0.05). The logistic regression analysis identified CB2-63 RR (p < 0.05) and a fibrosis score >3 (p < 0.005) as independently associated with an HAI >8. The observation that the CB2-63 RR variant is an independent predictor of extensive necroinflammation opens up new prospects in the study of CHB.
Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy. Electronic address: nicola.coppola@unina2.it.
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N
Coppola
Internal Medicine and Hepatology, Second University of Naples, Naples, Italy.
R
R
Zampino
Department of Experimental Medicine, Second University of Naples, Naples, Italy.
G
G
Bellini
Department of Clinical and Experimental Medicine and Surgery, Second University of Naples, Naples, Italy.
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M
Stanzione
Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy.
N
N
Capoluongo
Internal Medicine and Hepatology, Second University of Naples, Naples, Italy.
A
A
Marrone
Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy.
M
M
Macera
Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy.
G
G
Pasquale
Internal Medicine and Hepatology, Second University of Naples, Naples, Italy.
A
A
Boemio
Department of Experimental Medicine, Second University of Naples, Naples, Italy.
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S
Maione
Internal Medicine and Hepatology, Second University of Naples, Naples, Italy.
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LE
Adinolfi
Department of Woman, Child and of General and Specialized Surgery, Second University of Naples, Naples, Italy.
E Miraglia
EM
Del Giudice
Department of Mental Health and Public Medicine, Second University of Naples, Naples, Italy.
E
E
Sagnelli
Department of Woman, Child and of General and Specialized Surgery, Second University of Naples, Naples, Italy.
F
F
Rossi
D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D043885:Receptor, Cannabinoid, CB2 / Q000235:genetics*; D012720:Severity of Illness Index; D055815:Young Adult
C588309:CNR2 protein, human; D043885:Receptor, Cannabinoid, CB2
Cannabinoid receptor 2; HBV infection; cannabinoid system; chronic hepatitis B; liver disease