Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis.
BACKGROUND
The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC).


METHODS
Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed.


RESULTS
Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor.


CONCLUSIONS
PS-PLA1 expression in CRC is associated with tumor invasion and metastasis.
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan yiida-tky@umin.ac.jp.
Yuuki
Y
Iida
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Eiji
E
Sunami
Department of Gastrointestinal Surgery, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Hiroharu
H
Yamashita
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Masaya
M
Hiyoshi
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Soichiro
S
Ishihara
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Hironori
H
Yamaguchi
Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Asuka
A
Inoue
Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Kumiko
K
Makide
Department of Transfusion Medicine, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Nelson H
NH
Tsuno
Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan.
Junken
J
Aoki
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Joji
J
Kitayama
Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Toshiaki
T
Watanabe
D000368:Aged; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating; D010718:Phosphatidylserines / Q000378:metabolism*; D054466:Phospholipases A1 / Q000032:analysis / Q000502:physiology*
D010718:Phosphatidylserines; D054466:Phospholipases A1
Colorectal cancer; immunohistochemistry; metastasis; phosphatidylserine-specific phospholipase A1; tumor invasion