Red wine consumption is associated with fecal microbiota and malondialdehyde in a human population.
OBJECTIVE
Red wine intake has been associated with a lower risk of cardiovascular disease; its polyphenol content is the primary cause of antioxidant and anti-inflammatory properties attributed to this beverage. However, the way in which these activities are exerted is not yet clear, although some authors have proposed that intestinal microbiota could be implicated.


METHODS
The association between red wine intake, inflammation, and oxidative stress parameters and fecal microbial populations has been explored in 38 adult volunteers. Food intake was recorded by means of an annual food frequency questionnaire (FFQ). Energy, cholesterol, and ethanol intake were analyzed using the nutrient Food Composition Tables developed by Centro de Enseñanza Superior de Nutrición y Dietética (CESNID) and polyphenol intake was obtained from the Phenol-Explorer Database. Fecal levels of Akkermansia, Bacteroides, Bifidobacterium, Blautia coccoides group, Clostridium leptum group, Lactobacillus group, and Faecalibacterium prausnitzii were determined by quantitative polymerase chain reaction. Serum concentrations of C-reactive protein (CRP), malondialdehyde (MDA), total antioxidant capacity (TAC), cholesterol, triglycerides and glucose were analyzed by standard methods.


RESULTS
Subjects with regular consumption of red wine (mean = 100 ml/day) had lower serum concentrations of MDA and lower fecal levels of B. coccoides, C. leptum, Bifidobacterium, and Lactobacillus. A positive association between MDA levels and B. coccoides and Lactobacillus was also found.


CONCLUSIONS
Regular consumption of red wine appears to be associated with a reduced serum lipoperoxidation in which the intestinal microbiota may be involved.
a Department of Functional Biology , University of Oviedo, Facultad de Medicina , Oviedo , Asturias , SPAIN.
Adriana
A
Cuervo
Clara G de Los
CG
Reyes-Gavilán
Patricia
P
Ruas-Madiedo
Patricia
P
Lopez
Ana
A
Suarez
Miguel
M
Gueimonde
Sonia
S
González
D000368:Aged; D000428:Alcohol Drinking / Q000378:metabolism*; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004435:Eating; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D064307:Microbiota; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014920:Wine
D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides; D008315:Malondialdehyde; D002097:C-Reactive Protein; D002784:Cholesterol
antioxidants; fecal microbiota; oxidative stress; red wine