[A case of descending colon cancer with multiple liver metastases effectively treated with capecitabine/oxaliplatin (CapeOX) and bevacizumab].
A 57-year-old woman was referred to our hospital because of descending colon cancer with multiple liver metastases. Abdominal magneticresonanc e imaging (MRI) revealed 13 liver metastases across the lobes. We started combination che- motherapy with capecitabine/oxaliplatin (CapeOX) and bevacizumab. After 9 courses of the treatment, the number and size of the liver metastases were remarkably reduced on MRI. Left colectomy and partial hepatectomy were performed. Histopathological examination revealed no residual cancer cells in the colon but revealed a few cancer cells in 4 of 7 resected liver specimens. At 11 postoperative months, 1 liver metastasis reappeared, for which we performed laparoscopy-assisted partial hepatectomy. At 21 months after the second operation, the patient was well without any signs of recurrence. Thus, the combination chemotherapy with CapeOX and bevacizumab allowed for the successful resection of the tumor and metastasis in our patient who initially had unresectable colon cancer and multiple liver metastases.
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
Mae
M
Nakano
Hitoshi
H
Kameyama
Yoshifumi
Y
Shimada
Yoshifumi
Y
Hashimoto
Mana
M
Hosoi
Masato
M
Nakano
Hitoshi
H
Nogami
Takaaki
T
Hanyu
Kazuyasu
K
Takizawa
Takashi
T
Ishikawa
Jun
J
Sakata
Takashi
T
Kobayashi
Masahiro
M
Minagawa
Shinichi
S
Kosugi
Yu
Y
Koyama
Toshifumi
T
Wakai
D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D000068258:Bevacizumab; D000069287:Capecitabine; D044683:Colon, Descending / Q000473:pathology* / Q000601:surgery; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin
D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D003841:Deoxycytidine; D000068258:Bevacizumab; D000069287:Capecitabine; D005472:Fluorouracil