The prevalence and implications of BK virus replication in non-renal solid organ transplant recipients: A systematic review.
The significance of BK viruria and viremia in non-renal solid organ transplants is poorly understood. A systematic review was performed reviewing the incidence and implications of BK virus replication in non-renal solid organ transplants. Ninety-seven studies were identified, of which 18 including lung, heart, liver and pancreas transplants were included. The overall incidence of BK viruria and viremia was 20% and 3% respectively and 17 cases of BK nephropathy were identified. Heart transplant recipients had a higher overall incidence of BK viremia than other non-renal organ types, and the majority of cases of BK virus-associated nephropathy were in heart transplant recipients. The incidence of BK viremia was significantly lower in non-renal solid organ transplants than that of renal transplant recipients and BK virus-associated nephropathy was rare. BK virus-associated nephropathy may be considered in heart transplant recipients who have unexplained and persistent renal dysfunction not attributable to other causes.
College of Pharmacy, California Northstate University, 9700 West Taron Drive, Elk Grove, CA 95757, USA. Electronic address: vviswesh@cnsu.edu.
Velliyur
V
Viswesh
Department of Pharmacy, The University of Arizona Medical Center, University Campus, 1501 N. Campbell Ave, Tucson, AZ 85724, USA.
Sarah E
SE
Yost
Division of Nephrology and Hypertension, Department of Internal Medicine, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Bruce
B
Kaplan
D001739:BK Virus / Q000302:isolation & purification*; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D008297:Male; D016377:Organ Transplantation / Q000009:adverse effects* / Q000379:methods; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D014766:Viremia / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D014779:Virus Replication