[Short-term adjuvant hepatic arterial infusion chemotherapy after hepatic resection for hepatocellular carcinoma with macrovascular invasion].
BACKGROUND
Prognosis of patients with hepatocellular carcinoma (HCC) with macrovascular invasion is extremely poor even after hepatic resection. Herein, the efficacy of short-term adjuvant hepatic arterial infusion chemotherapy (HAI) for HCC with macrovascular invasion has been studied.


METHODS
From 1997 to 2013, 39 patients with HCC (BVp3, Vv3, or B3) undergoing hepatic resection were enrolled(group A: adjuvant HAI, n=21, group B: hepatectomy alone, n=18).


RESULTS
Clinical and demographic characteristics were similar in the 2 groups. Five-year disease-free survival (DFS) rates were 31.0% and 6.2% in group A and group B, respectively (p=0.008). In multivariate analysis for DFS, adjuvant HAI was the only independent prognostic factor (hazard ratio: 0.44, p=0.04). In group A, the intrahepatic recurrence rate was significantly lower (33% vs 72%, p=0.01) compared to group B, but rates of extrahepatic recurrence were similar in the 2 groups (19% vs 22%). The rate of overall survival was marginally higher in group A compared to group B (51% vs 19%, respectively, p= 0.06).


CONCLUSIONS
Short-term adjuvant HAI after hepatic resection may significantly improve DFS for HCC patients with macrovascular invasion.
Dept. of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University.
Hideaki
H
Takeyama
Hidetoshi
H
Nitta
Takaaki
T
Higashi
Keita
K
Sakamoto
Shigeki
S
Nakagawa
Mitsuhiro
M
Hayashi
Katsunori
K
Imai
Daisuke
D
Hashimoto
Akira
A
Chikamoto
Takatoshi
T
Ishiko
Toru
T
Beppu
Hideo
H
Baba
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness