[Basal cell carcinoma with matrical differentiation].
Basal cell carcinoma with matrical differentiation is a very rare variant of basal cell carcinoma. To our knowledge, less than 30 cases have been reported. This tumor is composed of basaloid lobules showing a differentiation toward the pilar matrix cells. Recently, it has been demonstrated that beta-catenin would interfer with physiopathogenesis of matrical tumors, in particular pilomatricomas, but also basal cell carcinomas with matrical differentiation. This is a new case, with immunohistochemical and molecular analysis of beta-catenin, in order to explain its histogenesis.
Laboratoire d'anatomie et cytologie pathologiques, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France. Electronic address: g.goldman@hotmail.fr.
Gabrielle
G
Goldman-Lévy
Laboratoire d'anatomie et cytologie pathologiques, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
Eric
E
Frouin
Département de pathologie, institut Bergonié, 229, cours de l'Argonne, 33076 Bordeaux, France.
Isabelle
I
Soubeyran
Service de dermatologie, hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
Géraldine
G
Maury
Service de dermatologie, hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
Bernard
B
Guillot
Laboratoire d'anatomie et cytologie pathologiques, hôpital Gui-de-Chauliac, 80, avenue Augustin-Fliche, 34295 Montpellier cedex, France.
Valérie
V
Costes
D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology*; D005260:Female; D006225:Hand; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology*
Basal cell carcinoma; Beta-catenin; Bêta-caténine; Carcinome basocellulaire à différenciation matricielle; Cellules fantômes; Matrical differentiation; Shadow cells