Soluble urokinase plasminogen activator receptor and hypertension among black South Africans after 5 years.
Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that links inflammation with cardiovascular risk. However, studies linking suPAR and hypertension are scant. First, we determined whether baseline suPAR is elevated in normotensive black South Africans who developed hypertension over 5 years, compared with those who remained normotensive; and second, whether hypertension is associated with suPAR. This substudy is embedded in the South African leg of the Prospective Urban and Rural Epidemiology study, performed in the North West Province. We investigated 429 normotensive individuals, of which 191 developed hypertension and 238 remained normotensive over 5 years. We determined suPAR from plasma (ethylenediaminetetraacetic acid) samples with the suPARnostic ELISA Kit and blood pressure with an OMRON HEM-757 device. Despite similar mean baseline suPAR levels (P=0.43), suPAR increased more in the group that developed hypertension compared with those who remained normotensive (14.2% vs. 6.94%; P=0.007). Five-year percentage change in systolic blood pressure correlated positively (r=0.23; P=0.002) and associated independently with baseline suPAR (β=0.14; P=0.043), only in participants who developed hypertension. Participants were 1.41 times more likely (P=0.015) to develop hypertension with 1 s.d. increase in percentage change in suPAR levels over 5 years. Change in systolic blood pressure was associated with baseline suPAR in hypertensive participants and change in suPAR with hypertensive status. This study highlights the need for more research on the role of suPAR in hypertension and cardiovascular disease development in black South Africans.
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Shani
S
Botha
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Carla Mt
CM
Fourie
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Rudolph
R
Schutte
Clinical Research Centre 136, Copenhagen University Hospital, Hvidovre, Denmark.
Jesper
J
Eugen-Olsen
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.
Aletta E
AE
Schutte
D015415:Biomarkers / Q000097:blood; D044383:Black People; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D011446:Prospective Studies; D055293:Receptors, Urokinase Plasminogen Activator / Q000097:blood*; D013019:South Africa / Q000453:epidemiology
D015415:Biomarkers; D055293:Receptors, Urokinase Plasminogen Activator