[Preparation of solid dispersion of triterpenoid acids from Eriobotrya japonica leaf and study on their dissolution in vitro].
To prepare the solid dispersion of Eriobotrya japonica leaf triterpenoid acids(EJA) in order to enhance their dissolution characteristics in vitro.


METHODS
Taking ursolic acid and oleanolic acid in vitro dissolution as an indicator, the influence of factors including different water-soluble carriers (PEG 6000, PVPk30 and P188) and the drug/carrier weight ratio for the preparation of solid dispersion were examined using single factor experiment. Differential scanning calorimetry (DSC) and X-ray diffraction (X-RD) were used to describe the characterization of solid dispersion.


RESULTS
P188 was used as appropriate carrier for the preparation of solid dispersion and the drug/carrier weight ratio was 1:5. The X-RD and DSC showed EJA existed in the solid dispersion as the way of amorphous. The dissolution rate of EJA solid dispersion was significantly higher than physical mixture and EJA.


CONCLUSIONS
The solid dispersion prepared with P188 can significantly increase the solubility and dissolution of EJA in vitro. This study provides the scientific evidence for further preparation of solid dispersion tablet.
Hui-Hui
HH
Shi
Xue-Ping
XP
Cai
Jian-Ming
JM
Ju
Zhen-Hai
ZH
Zhang
Jun-Lei
JL
Hua
Han
H
Lv
Wei-Lin
WL
Li
D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D031983:Eriobotrya / Q000737:chemistry*; D066298:In Vitro Techniques; D011092:Polyethylene Glycols; D012995:Solubility; D014315:Triterpenes / Q000302:isolation & purification*; D014867:Water; D014961:X-Ray Diffraction
D004337:Drug Carriers; D014315:Triterpenes; D014867:Water; D011092:Polyethylene Glycols