Correlation between the serum luteinizing hormone to folliclestimulating hormone ratio and the anti-Müllerian hormone levels in normo-ovulatory women.
Serum anti-Müllerian hormone (AMH) levels are regarded as an age-specific marker for predicting the ovarian reserve in women of reproductive age. Some studies have shown that the luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio can be used as a predictor of ovarian reserve. The purpose of this study was to assess the variation of LH/FSH ratio with aging and to evaluate the correlation between serum LH/FSH ratio and AMH levels as a predictor of the ovarian reserve in normo-ovulatory women. We retrospectively analyzed the day 3 serum hormone levels in 1,251 patients (age range: 20-50 yr) between January 2010 and January 2011. We divided the patients into 6 groups according to their age. Relation between serum AMH level and LH/FSH ratio was analyzed statistically. The serum AMH level was inversely correlated with age (r = -0.400, P < 0.001). A significant negative correlation was found between serum LH/FSH ratio and age (r = -0.213, P < 0.001). There was a significant partial correlation between serum LH/FSH ratio and AMH level when adjusted by age (r = 0.348, P < 0.001). The LH/FSH ratio could be considered as a useful marker for the ovarian reserve and could be applied to the clinical evaluation with AMH.
Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea.
Jong Eun
0000-0002-2933-9265
JE
Lee
Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea.
Sang Ho
0000-0003-1754-2212
SH
Yoon
Department of Obstetrics and Gynecology, Kwandong University, Cheil General Hospital, Seoul, Korea.
Hye Ok
0000-0002-3899-7710
HO
Kim
Department of Obstetrics and Gynecology, Kwandong University, Cheil General Hospital, Seoul, Korea.
Eung Gi
0000-0003-1701-4997
EG
Min
D000328:Adult; D000375:Aging / Q000097:blood; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008598:Menstruation / Q000097:blood / Q000502:physiology; D008875:Middle Aged; D065851:Ovarian Reserve / Q000502:physiology*; D010060:Ovulation / Q000097:blood* / Q000502:physiology; D012189:Retrospective Studies; D055815:Young Adult
D054304:Anti-Mullerian Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Anti-Müllerian Hormone; LH/FSH Ratio; Ovarian Reserve; Regular Menstruation