One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles.
This paper described a decarboxylative deaminative dual-coupling reaction of amino acids with indoles to afford BIM scaffolds and its further application to the one-pot total synthesis of natural products. This method featured a stimulating example of activating amino acids in one pot as multi-carbon building blocks for transformation into final targets which are equipped with amino acid side chain backbones.
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education; College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chwuax@mail.ccnu.edu.cn.
Jiachen
J
Xiang
Jungang
J
Wang
Miao
M
Wang
Xianggao
X
Meng
Anxin
A
Wu
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*
D000085:Acetates; D000596:Amino Acids; D001688:Biological Products; D002087:Butyrates; D007211:Indoles