Synthesis, structural and antioxidant studies of some novel N-ethyl phthalimide esters.
A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.
X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia; Department of Chemistry, Alva's Institute of Engineering & Technology, Mijar, Karnataka, India.
C S
CS
Chidan Kumar
X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia.
Wan-Sin
WS
Loh
Department of Sugar Technology & Chemistry, University of Mysore, Sir M.V. PG Center, Tubinakere, Karnataka, India.
Siddegowda
S
Chandraju
Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, Perak, Malaysia.
Yip-Foo
YF
Win
Klinik Kesihatan Batu Kawa, Jalan Stapok Utara/ Utara, Kuching, Sarawak, Malaysia.
Weng Kang
WK
Tan
X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia.
Ching Kheng
CK
Quah
X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Hoong-Kun
HK
Fun
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
D000975:Antioxidants; D004952:Esters; D016166:Free Radical Scavengers; D010797:Phthalimides