[The effects of dexamethasone and hypoxia on the content of active caspase-3 in the cerebellum and the behavior of neonatal rats].
Synthetic glucocorticoid dexamethasone decreased locomotor activity of neonatal rats 120 h after administration. Behavioral changes were associated with an increase in the content of active caspase-3 in the cerebellum. We found that expression of this apoptotic protease was similar to the control value when dexamethasone action was combined to hypoxic treatment to rats; however, the locomotor activity decreased to the hormone action did not recovered. We found that proapoptotic action of dexamethasone was blocked by hypoxic treatment; however, it was not sufficient for prevention of the effect of hormone on behavior.
V V
VV
Bulygina
P N
PN
Men'shanov
D A
DA
Lanshakov
N N
NN
Dygalo
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001835:Body Weight / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism*; D002531:Cerebellum / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D000860:Hypoxia / Q000201:enzymology / Q000503:physiopathology*; D007150:Immunohistochemistry; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D017208:Rats, Wistar
D005938:Glucocorticoids; D003907:Dexamethasone; C505410:Casp3 protein, rat; D053148:Caspase 3