A study of the human skin-whitening effects of resveratryl triacetate.
Resveratrol has a variety of bioactivities that include its anti-melanogenic effects, but its use in cosmetics has been challenging partly because of its chemical instability. Resveratryl triacetate (RTA) is a prodrug that can enhance stability. The purpose of this study was to examine the skin safety and whitening effects of RTA in human subjects. The primary skin irritation potentials of RTA and resveratrol were tested at 0.1 and 0.5 % on human subjects. Resveratrol at a concentration of 0.5 % induced weak skin irritation, whereas RTA did not induce any skin responses. The skin-whitening efficacy of a cosmetic formulation containing 0.4 % RTA was evaluated in two different test models. In the artificial tanning model, the test product and the control product were applied twice daily to the skin of the forearms of 22 human subjects after pigmentation induction by ultraviolet irradiation. Applying the test and the control products to the artificial tanning model for 8 weeks increased the individual topology angles (ITA°) by 17.06 and 13.81 %, respectively, a difference that was statistically significant (p < 0.05). In the hyperpigmentation model, the test product and the control product were applied twice daily to the faces of 21 human subjects. The averaged intensity of the hyperpigmented spots decreased by 2.67 % in the test group and 1.46 % in the control group, a difference that was statistically significant (p < 0.05). Therefore, RTA incorporated into cosmetic formulations can whiten human skin without inducing skin irritation.
Dermapro Skin Research Center, Dermapro Ltd., Seoul, Republic of Korea.
Ja Hyun
JH
Ryu
Jin Kyung
JK
Seok
Sang Mi
SM
An
Ji Hwoon
JH
Baek
Jae Sook
JS
Koh
Yong Chool
YC
Boo
D000328:Adult; D003358:Cosmetics; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000188:drug therapy*; D008543:Melanins / Q000378:metabolism; D008875:Middle Aged; D010858:Pigmentation / Q000187:drug effects*; D011355:Prodrugs / Q000008:administration & dosage* / Q000009:adverse effects; D000077185:Resveratrol; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D062327:Skin Lightening Preparations / Q000008:administration & dosage* / Q000009:adverse effects; D013267:Stilbenes / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D055108:Sunbathing; D014466:Ultraviolet Rays
D003358:Cosmetics; D008543:Melanins; D011355:Prodrugs; D062327:Skin Lightening Preparations; D013267:Stilbenes; C000603669:resveratryl triacetate; D000077185:Resveratrol