Anti-CCP antibody levels are not associated with MS: results from a case-control study.
Citrullinated proteins have been suggested to play a critical role in the pathogenesis of multiple sclerosis (MS). Anticyclic citrullinated peptide (anti-CCP) antibody is used in the early diagnosis of rheumatoid arthritis (RA). The objective of this study was to investigate the presence of anti-CCP antibody in patients with MS compared to RA patients and healthy controls. Fifty patients with MS (38 females, 12 males; mean age 36.72 ± 8.82 years), 52 patients with RA (40 females, 12 males; mean age 40.87 ± 10.17 years), and 50 healthy controls (32 females, 18 males; mean age 38.22 ± 11.59 years) were included in this study. The levels of serum anti-CCP antibody were measured using an enzyme-linked immunosorbent assay (ELISA). The results of the study showed that anti-CCP antibody levels were significantly higher in RA patients versus MS or healthy controls (P < 0.001). Moreover, anti-CCP antibody was positive in 43 (83%) patients with RA, while it was negative in all MS patients as well as in all healthy controls. Also, no significant correlation was found between the anti-CCP levels and EDSS scores (r = -0.250). In conclusion, the results of this study did not support a positive association between serum anti-CCP antibody and MS.
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Mahmut
M
Alpayci
Department of Neurology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Aysel
A
Milanlioglu
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Veysel
V
Delen
Department of Neurology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Mehmet Nuri
MN
Aydin
Department of Medical Microbiology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Huseyin
H
Guducuoglu
Department of Medical Microbiology, Faculty of Medicine, Yuzuncu Yil University, 65100 Van, Turkey.
Yasemin
Y
Bayram
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology / Q000473:pathology; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D002956:Citrulline / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology / Q000473:pathology; D004676:Myelin Basic Protein / Q000378:metabolism; D010455:Peptides / Q000097:blood* / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D004676:Myelin Basic Protein; D010455:Peptides; D002956:Citrulline