Iodoarene-catalyzed cyclizations of unsaturated amides.
The cyclization of N-alkenylamides catalyzed by iodoarenes under oxidative conditions is presented. Five-, six-, and seven-membered rings with a range of substitutions can be prepared by this route. Preliminary data from the use of chiral iodoarenes as precatalysts show that enantiocontrol is feasible.
Department of Chemistry, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.
Ali
A
Alhalib
Department of Chemistry, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.
Somaia
S
Kamouka
Department of Chemistry, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K.
Wesley J
WJ
Moran