Related hematopoietic cell donor care: is there a role for unrelated donor registries?
In almost half of allogeneic hematopoietic progenitor cell (HPC) transplants, a related donor (RD) is used, yet a lack of standardized guidelines means that their care is heterogeneous. Changes to regulatory standards aim to improve uniformity, but adherence to these regulations can prove logistically difficult for the transplant centers (TCs) managing RDs. Discussion has ensued around possible alternative models of related donor care and a session at the European Society for Blood and Marrow Transplantation (EBMT) annual meeting in 2013 debated the question of whether a role exists for unrelated donor registries in the management of 'related' donors. In this overview, we discuss the issues raised at this debate and the pros and cons of donor registry involvement in various aspects of RD management. By examining existing models of related donor care that have been adopted by members of the World Marrow Donor Association (WMDA), we look for ways to enhance and homogenize RD care, while also enabling transplant centers to meet standards required for mandatory accreditation.
Anthony Nolan Research Institute, UCL Cancer Centre, London, UK.
C
C
Anthias
Europdonor Foundation, Leiden, The Netherlands.
S M
SM
van Walraven
Department of Clinical Immunology, Aarhus University Hospital, Skejby, Denmark.
B S
BS
Sørensen
Swiss Blood stem cells, Bern, Switzerland.
G N
GN
de Faveri
Europdonor Foundation, Leiden, The Netherlands.
M
M
Fechter
Department of Haematology, Bristol Royal Hospital for Children, Bristol, UK.
J
J
Cornish
Division of Hematology and Bone Marrow Transplantation, IRCCS San Martino, Genova, Italy.
A
A
Bacigalupo
1] Zentrales Knochenmarkspender-Register für Deutschland, Ulm, Germany [2] Deutsches Register für Stammzelltransplantationen (DRST), Ulm, Germany.
C
C
Müller
National Marrow Donor Program, Minneapolis, MN, USA.
M
M
Boo
1] Anthony Nolan Research Institute, UCL Cancer Centre, London, UK [2] Department of Haemato-oncology, The Royal Marsden Hospital Downs Rd, Sutton, UK.
B E
BE
Shaw
D003226:Congresses as Topic; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D012042:Registries; D061349:Unrelated Donors