Pd-catalyzed difluoromethylation of vinyl bromides, triflates, tosylates, and nonaflates.
Pd-catalyzed difluoromethylation of di-, tri- or tetra-substituted vinyl bromides, triflates, tosylates and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China).
Dalu
D
Chang
Yang
Y
Gu
Qilong
Q
Shen
D001557:Benzenesulfonates / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D008698:Mesylates / Q000737:chemistry*; D008745:Methylation; D010165:Palladium / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
C573194:4-methylbenzenesulfonic acid; D001557:Benzenesulfonates; D008698:Mesylates; D014753:Vinyl Compounds; D010165:Palladium; C003763:vinyl bromide; C012077:trifluoromethanesulfonic acid
alkenes; cross-coupling; fluorine; fluoroalkylation; palladium