Percutaneous mitral valve repair using the MitraClip system in patients with anemia.
BACKGROUND
Patients with anemia show a negative outcome in percutaneous coronary intervention, transcatheter aortic valve replacement and cardiac surgery. The impact of anemia on periprocedural major adverse cardiac and cerebrovascular events (MACCE) and mortality in patients undergoing treatment of severe mitral regurgitation (MR) with percutaneous mitral valve repair using the MitraClip system is not known.


OBJECTIVE
To assess whether percutaneous mitral valve repair with the MitraClip system is safe and effective in patients with anemia.


RESULTS
80 patients with severe and moderate-to-severe MR were included in this open-label observational single-center study. Anemia was prevalent in 51.3% of patients (n=41). MitraClip devices were successfully implanted in 97.6% (n=40) of patients with anemia and in 97.4% (n=38) of patients without anemia (p=0.971). Periprocedural MACCE occurred in 4.9% (n=2) of patients with anemia and 5.1% (n=2) of patients without anemia (p=0.959). Thirty-day mortality was 2.4% (n=1) in patients with anemia and 5.1% (n=2) in patients without anemia (p=0.611). Follow up of up to 12 months showed a significant improvement of NYHA class and quality of life evaluated by the Minnesota Living with Heart Failure Questionnaire in both groups. One-year survival was 80.5% in patients with anemia and 84.6% in patients without anemia (p=0.634).


CONCLUSIONS
Mitral valve repair with the MitraClip system can be performed safely and efficiently in patients with anemia. Anemia does not affect clinical outcome and quality of life in patients undergoing mitral valve repair.
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Katharina
K
Hellhammer
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Jan
J
Balzer
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Tobias
T
Zeus
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Christos
C
Rammos
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Svenja
S
Niebel
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Laura
L
Kubatz
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Rabea
R
Wagstaff
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany.
Malte
M
Kelm
University Hospital Düsseldorf, Medical Faculty, Dept. of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstraße 5, 40225 Düsseldorf, Germany. Electronic address: Tienush.Rassaf@med.uni-duesseldorf.de.
Tienush
T
Rassaf
D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications*; D006328:Cardiac Catheterization / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000503:physiopathology / Q000601:surgery; D058386:Mitral Valve Annuloplasty / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology / Q000523:psychology; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
Anemia; Mitral regurgitation; Percutaneous mitral valve repair