Is There Consistency between the Binding Affinity and Inhibitory Potential of Natural Polyphenols as α-amylase Inhibitors?
The inhibitory potential of natural polyphenols for α-amylases has attracted great interests among researchers. The structure-affinity properties of natural polyphenols binding to α-amylase and the structure-activity relationship of dietary polyphenols inhibiting α-amylase were deeply investigated. There is a lack of consistency between the structure-affinity relationship and the structure-activity relationship of natural polyphenols as α-amylase inhibitors. Is it consistent between the binding affinity and inhibitory potential of natural polyphenols as with α-amylase inhibitors? It was found that the consistency between the binding affinity and inhibitory potential of natural polyphenols as with α-amylase inhibitors is not equivocal. For example, there is no consistency between the binding affinity and the inhibitory potential of quercetin and its glycosides as α-amylase inhibitors. However, catechins with higher α-amylase inhibitory potential exhibited higher affinity with α-amylase.
a Yancheng Institute of Technology , Yancheng , China.
Wei
W
Xu
a Yancheng Institute of Technology , Yancheng , China.
Rong
R
Shao
b Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg , Am Hubland , Würzburg , Germany.|c Institute of Chinese Medical Sciences , State Key Laboratory of Quality Research in Chinese Medicine, University of Macau , Taipa , Macau , China.
Jianbo
J
Xiao
D000872:Anthocyanins / Q000737:chemistry; D002392:Catechin / Q000737:chemistry; D003373:Coumaric Acids / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D062385:Hydroxybenzoates / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry*; D044945:Proanthocyanidins / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry; D013329:Structure-Activity Relationship; D013634:Tannins / Q000737:chemistry; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000737:chemistry
D000872:Anthocyanins; D003373:Coumaric Acids; D005419:Flavonoids; D062385:Hydroxybenzoates; D059808:Polyphenols; D044945:Proanthocyanidins; D013267:Stilbenes; D013634:Tannins; D002392:Catechin; D000516:alpha-Amylases; C017616:phenolic acid
Structure–affinity relationship; polyphenols; structure–activity relationship; α-amylase