Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm. Lamins bind to a growing number of nuclear protein complexes and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, gene regulation, genome stability, differentiation, and tissue-specific functions. The lamin-based complexes and their specific functions also provide insights into possible disease mechanisms for human laminopathies, ranging from muscular dystrophy to accelerated aging, as observed in Hutchinson-Gilford progeria and atypical Werner syndromes.
Department of Genetics, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel; email: gru@vms.huji.ac.il.
Yosef
Y
Gruenbaum
Roland
R
Foisner
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D034882:Lamins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011371:Progeria / Q000473:pathology
D002843:Chromatin; D034882:Lamins
chromatin; intermediate filament; laminopathies; lamins; nuclear envelope; nuclear mechanics; nuclear organization