Arginine adjunctive therapy in active tuberculosis.
Background. Dietary supplementation has been used as a mechanism to augment the immune system. Adjunctive therapy with L-arginine has the potential to improve outcomes in active tuberculosis. Methods. In a randomized clinical trial 63 participants with smear-positive pulmonary tuberculosis in Markazi Province of Iran were given arginine or placebo for 4 weeks in addition to conventional chemotherapy. The final treatment success, sputum conversion, weight gain, and clinical symptoms after one and two months were considered as primary outcomes and secondary outcomes were ESR, CRP, and Hg. Data were collected and analyzed with SPSS software (ver. 18). Results. Arginine supplementation reduced constitutional symptoms (P = 0.032) in patients with smear-positive TB at the end of the first month of treatment. Arginine treated patients had significantly increased BMI at the end of the first and second months of treatment (P = 0.032 and P = 0.04) and a reduced CRP at the end of the first month of treatment (P = 0.03) versus placebo group. Conclusion. Arginine is useful as an adjunctive therapy in patients with active tuberculosis, in which the effects are more likely mediated by the increased production of nitric oxide and improved constitutional symptoms and weight gain. This trial is registered with Clinical Trials Registry of Iran: IRCT201211179855N2.
Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak 38159 34798, Iran ; Tuberculosis and Pediatric Infectious Diseases Research Center, Arak University of Medical Sciences, Arak 38159 34798, Iran.
Aliasghar
0000-0002-9593-6391
A
Farazi
School of Medicine, Arak University of Medical Sciences, Arak 38159 34798, Iran.
Omid
O
Shafaat
Department of Infectious Disease, School of Medicine, Arak University of Medical Sciences, Arak 38159 34798, Iran ; Tuberculosis and Pediatric Infectious Diseases Research Center, Arak University of Medical Sciences, Arak 38159 34798, Iran.
Masoomeh
M
Sofian
Tuberculosis and Pediatric Infectious Diseases Research Center, Arak University of Medical Sciences, Arak 38159 34798, Iran.
Manijeh
M
Kahbazi