Versicolols A and B, two new prenylated isocoumarins from endophytic fungus Aspergillus versicolor and their cytotoxic activity.
Versicolols A and B (1 and 2), two rare prenylated isocoumarin derivatives, along with five known isocoumarins (3-7) were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. The results showed that compounds 1 exhibited weak cytotoxicity against A549 and MCF7 cells with IC50values of 9.4 and 8.8 μm, and compound 2 exhibited weak cytotoxicity against SHSY5Y and MCF7 cells with IC50values of 8.2 and 6.8 μm, respectively.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Min
M
Zhou
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Jie
J
Lou
College of Resource and Environment, Yuxi Normal University, Yuxi, 653100, People's Republic of China.
Yin-Ke
YK
Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Yue-De
YD
Wang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Kun
K
Zhou
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Bing-Kun
BK
Ji
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Wei
W
Dong
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China.
Xue-Mei
XM
Gao
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China. dugang2006@163.com.
Gang
G
Du
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, People's Republic of China. huqiufena@163.com.
Qiu-Fen
QF
Hu
D000072283:A549 Cells; D001230:Aspergillus; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D060026:Endophytes; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D061986:MCF-7 Cells; D054876:Prenylation / Q000502:physiology*
D003603:Cytotoxins; D049934:Isocoumarins
Aspergillus versicolor; Cytotoxicity; Prenylated isocoumarins