Reduced serum levels of adiponectin in tension-type headache.
OBJECTIVE
Inflammatory mediators have been studied in tension type headache (TTH) pathophysiology; however, their role is not yet well established. The aim of the present study was to investigate adiponectin (ADP) and its association with clinical parameters and psychiatric comorbidities in TTH patients.


METHODS
This was a cross sectional study including TTH patients and controls. Beck Depression (BDI) and Anxiety (BAI) Inventories, and Headache Impact Test (HIT-6) were recorded. Serum levels of ADP were measured by ELISA.


RESULTS
Forty-eight TTH patients and forty-eight controls without headache were enrolled in the study. ADP levels were significantly lower among patients with TTH [31.1 (20.4-69.20) versus 37.8 (24.9-71.4) ng/mL (P=0.008)]. ADP levels were not influenced by BDI and BAI scores, body mass index (BMI), or HIT-6.


CONCLUSIONS
ADP levels were reduced in TTH, independently of psychiatric comorbidities, BMI, and headache impact.
Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil. Electronic address: contato@renandomingues.med.br.
Renan B
RB
Domingues
Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Halina
H
Duarte
Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Natália P
NP
Rocha
Neurosciences Postgraduation Program, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; Interdisciplinary Laboratory of Medical Investigation, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Antonio L
AL
Teixeira
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001007:Anxiety / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018781:Tension-Type Headache / Q000097:blood* / Q000523:psychology*
C499918:ADIPOQ protein, human; D052242:Adiponectin
Adiponectin (ADP); Anxiety; Chronic TTH; Depression; Tension-type headache (TTH)