Fe-Au and Fe-Ag composites as candidates for biodegradable stent materials.
In this study, Fe-Ag and Fe-Au composites were fabricated by powder metallurgy using spark plasma sintering. Their microstructures, mechanical properties, and biocorrosion behavior were investigated by using optical microscopy, X-ray diffraction, environment scanning electronic microscopy, compressive test, electrochemical measurements, and immersion tests. Microstructure characterization indicated that the as-sintered iron-based materials obtained much finer grains than that of as-cast pure iron. Phase analysis showed that the Fe-Ag composites were composed of α-Fe and pure Ag phases, and Fe-Au composites consisted of α-Fe and Au phases. Compressive test showed that the improved mechanical strengths were obtained in as-sintered iron-based materials, among which the Fe-5 wt %Ag exhibited the best mechanical properties. The electrochemical and immersion tests revealed that the addition of Ag and Au could increase the corrosion rate of the iron matrix and change the corrosion mode into more uniform one. Based on the results of cytotoxicity evaluation, it was found that all the experimental material extracts performed no significant toxicity on the L-929 cells and EA. hy-926 cells, whereas a considerable inhibition on the proliferation of vascular smooth muscle cells was observed. The hemocompatibility tests showed that the hemolysis of all the experimental materials was within the range of 5%, which is the criteria value of biomaterials with good hemocomaptibility. The amount of platelet adhered on the surface of as-sintered iron-based materials was lower than that of as-cast pure iron, and the morphology of platelets kept smoothly spherical on the surface of all the experimental materials.
Department of Materials Science and Engineering, State Key Laboratory for Turbulence and Complex System, College of Engineering, Peking University, Beijing, 100871, China.
Tao
T
Huang
Department of Advanced Materials and Nanotechnology, Center for Biomedical Materials and Tissue Engineering, College of Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Jian
J
Cheng
Department of Materials Science and Engineering, State Key Laboratory for Turbulence and Complex System, College of Engineering, Peking University, Beijing, 100871, China.
Dong
D
Bian
Department of Materials Science and Engineering, State Key Laboratory for Turbulence and Complex System, College of Engineering, Peking University, Beijing, 100871, China.|Department of Advanced Materials and Nanotechnology, Center for Biomedical Materials and Tissue Engineering, College of Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Yufeng
Y
Zheng
D020341:Absorbable Implants; D000818:Animals; D002460:Cell Line; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing / Q000379:methods; D051379:Mice; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D015607:Stents
D012834:Silver; D006046:Gold; D007501:Iron
Fe-Ag composite; Fe-Au composite; biocompatibility; biodegradable metal; corrosion; in vitro