Live birth and cumulative live birth rates in expected poor ovarian responders defined by the Bologna criteria following IVF/ICSI treatment.
OBJECTIVE
To determine the live birth and cumulative live birth rates of expected poor ovarian responders according to the Bologna criteria and to compare their outcomes with those of expected normal responders.


METHODS
Retrospective analysis.


METHODS
University infertility clinic.


METHODS
A total of 1,152 subfertile women undergoing their first in vitro fertilization (IVF) cycle.


METHODS
Women were classified into 4 groups according to the Bologna criteria for comparison.


METHODS
Live birth and cumulative live birth rates.


RESULTS
Women with expected poor response (POR) had the lowest live birth rate than the other 3 groups (23.8%, p = 0.031). Cumulative live birth rates were significantly lower in those with expected POR than those with expected normal ovarian response (NOR) (35.8% vs 62.8%, p<0.0001). In the subgroup analysis, the cumulative live birth rates in expected PORs were significantly lower in those who had ≤3 oocytes retrieved (18.6% for ≤3 oocytes vs 44.0% for >3 oocytes, p = 0.006) whereas the live birth rates in fresh cycle did not differ (17.8% vs 30.9%, p = 0.108).


CONCLUSIONS
Women who were expected POR according to the Bologna criteria had lower live birth and cumulative live birth than expected NOR but they still can achieve reasonable treatment outcomes and IVF treatment should not be precluded.
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Joyce
J
Chai
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Vivian Chi-Yan
VC
Lee
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Tracy Wing-Yee
TW
Yeung
Hang Wun Raymond
HW
Li
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Raymond Wun-Hang
RW
Li
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Pak-Chung
PC
Ho
Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region, China.
Ernest Hung-Yu
EH
Ng
D000328:Adult; D001723:Birth Rate; D005260:Female; D005307:Fertilization in Vitro; D006723:Hong Kong; D006801:Humans; D050498:Live Birth; D011247:Pregnancy