[Thalidomide-associated hypothyroidism in a patient with multiple myeloma].
Thalidomide is highly effective against multiple myeloma, but some patients must discontinue this medication due to adverse effects. We present herein an instructive case report on thalidomide-associated hypothyroidism in a patient with multiple myeloma. Thyroid hormone replacement therapy allowed us to restart administration of thalidomide, a potentially life-saving therapy. Known adverse effects of thalidomide, such as lethargy, constipation, and bradycardia, are potential symptoms of hypothyroidism, but we tend to overlook drug-associated hypothyroidism. Our case highlights the importance of routinely testing thyroid function in patients receiving thalidomide therapy.
Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center.
Ikue
I
Okamura
Takashi
T
Ikeda
Ken
K
Sato
Fumihiko
F
Kimura
D000368:Aged; D003248:Constipation / Q000139:chemically induced; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis; D000077269:Lenalidomide; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use; D013960:Thyroid Function Tests / Q000379:methods
D013792:Thalidomide; D000077269:Lenalidomide