p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis.
BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell-extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy.
Maria del Pilar
Mdel P
Camacho Leal
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy.
Marianna
M
Sciortino
European Cancer Stem Cell Research Institute and Cardiff School of Biosciences, Cardiff University, Cardiff, UK.
Giusy
G
Tornillo
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy.
Shana
S
Colombo
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy.
Paola
P
Defilippi
Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy. Electronic address: sara.cabodi@unito.it.
Sara
S
Cabodi
D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D050719:Crk-Associated Substrate Protein / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D005109:Extracellular Matrix; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D040542:Mechanotransduction, Cellular; D051379:Mice; D009024:Morphogenesis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009928:Organ Specificity; D010766:Phosphorylation; D017434:Protein Structure, Tertiary
C493841:BCAR1 protein, human; D050719:Crk-Associated Substrate Protein
Adaptor protein; Cancer; Cell motility; Development; Intracellular signaling pathways; p130Cas/BCAR1