Icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels in the hippocampus of the senescence- accelerated mouse.
At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.
Department of Neurosurgery, First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410007, Hunan Province, China.
Zhanwei
Z
Zhang
Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Ting
T
Zhang
Department of Traditional Chinese Medicine, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Keli
K
Dong
Alzheimer's disease; hippocampus; icariin; neural regeneration; phosphorylated cyclic adenosine monophosphate response element binding protein