NIA's Intervention Testing Program at 10 years of age.
The previous 20 years of basic research on aging has identified a large number of genes and gene products whose expression can be manipulated in a variety of ways to increase the healthy life span of animal models such as yeast, nematodes, fruit flies, and mice. In an overt attempt to capitalize on this information, the National Institute on Aging (NIA) began a program in 2003 to identify nutritional and pharmaceutical interventions that could be safely employed to extend the healthy life span of mice. This program is called the Intervention Testing Program (ITP), and this article briefly describes the development of this initiative and some of the early success achieved during its first 10 years (2004-2014) of operation.
College of Biological Sciences, University of Minnesota, St. Paul, MN, 55108, USA, warne033@centurylink.net.
Huber R
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Warner
D000818:Animals; D035843:Biomedical Research / Q000458:organization & administration*; D006801:Humans; D008136:Longevity / Q000187:drug effects; D051379:Mice; D008954:Models, Biological; D054561:National Institute on Aging (U.S.); D016730:Program Development; D012107:Research Design; D020123:Sirolimus / Q000494:pharmacology; D014481:United States
D020123:Sirolimus