Veno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model.
BACKGROUND
Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ventilation at lower tidal volume enhances pulmonary hypertension and might induce right ventricular (RV) failure. We investigated if extracorporeal veno-venous CO2 removal therapy could have beneficial effects on pulmonary circulation and RV function.


METHODS
This study was performed on an experimental model of ARDS obtained in eight anaesthetized pigs connected to a volume-cycled ventilator. A micromanometer-tipped catheter was inserted into the main pulmonary artery and an admittance micromanometer-tipped catheter was inserted into the right ventricle. RV-arterial coupling was derived from RV pressure-volume loops. ARDS was obtained by repeated bronchoalveolar lavage. Protective ventilation was then achieved, and the pigs were connected to a pump-driven extracorporeal membrane oxygenator (PALP, Maquet, Germany) in order to achieve CO2 removal.


RESULTS
ARDS induced severe hypercapnic acidosis. Systolic pulmonary artery pressure significantly increased from 29.6±1.8 to 43.9±2.0 mmHg (P<0.001). After the PALP was started, acidosis was corrected and normocarbia was maintained despite protective ventilation. Pulmonary artery pressure significantly decreased to 31.6±3.2 mmHg (P<0.001) and RV-arterial coupling significantly improved (RV-arterial coupling index=1.03±0.33 vs. 0.55±0.41, P<0.05).


CONCLUSIONS
Veno-venous CO2 removal therapy enabled protective ventilation while maintaining normocarbia during ARDS. CO2 removal decreased pulmonary hypertension and improved RV function. This technique may be an effective lung- and RV-protective adjunct to mechanical ventilation.
Medical Intensive Care Unit, University Hospital of Liege, Liege, Belgium; GIGA-Research, Cardiovascular Sciences, University of Liege, Liege, Belgium.
P
P
Morimont
J
J
Guiot
T
T
Desaive
V
V
Tchana-Sato
N
N
Janssen
A
A
Cagnina
D
D
Hella
F
F
Blaffart
J-O
JO
Defraigne
B
B
Lambermont
D000138:Acidosis / Q000209:etiology; D000758:Anesthesia; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D002245:Carbon Dioxide / Q000097:blood*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D011652:Pulmonary Circulation; D011669:Pulmonary Wedge Pressure; D012121:Respiration, Artificial / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy*; D013552:Swine; D014655:Vascular Resistance
D002245:Carbon Dioxide