Towards a complex system understanding of bipolar disorder: A map based model of a complex winnerless competition.
Bipolar disorder is characterized by repeated erratic episodes of mania and depression, which can be understood as pathological complex system behavior involving cognitive, affective and psychomotor disturbance. In order to illuminate dynamical aspects of the longitudinal course of the illness, we propose here a novel complex model based on the notion of competition between recurrent maps, which mathematically represent the dynamics of activation in excitatory (Glutamatergic) and inhibitory (GABAergic) pathways. We assume that manic and depressive states can be considered stable sub attractors of a dynamical system through which the mood trajectory moves. The model provides a theoretical framework which can account for a number of complex phenomena of bipolar disorder, including intermittent transition between the two poles of the disorder, rapid and ultra-rapid cycling of episodes and manicogenic effects of antidepressants.
Complex Systems and Cybernetics Control Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran.
Fatemeh
F
Hadaeghi
Complex Systems and Cybernetics Control Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology, Tehran, Iran. Electronic address: mrhashemigolpayegani@aut.ac.ir.
Mohammad Reza
MR
Hashemi Golpayegani
Faculty of Health, Arts and Design, Swinburne University of Technology, Hawthorn, VIC, Australia.
Greg
G
Murray
D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009435:Synaptic Transmission
D000928:Antidepressive Agents
Bipolar disorder; Chaotic intermittency; Recurrent map; Winnerless competition