Physical Activity is Associated with Better Neurocognitive and Everyday Functioning Among Older Adults with HIV Disease.
We examined the association between physical activity (PA), neurocognitive impairment (NCI), and instrumental activities of daily living (IADLs) among older HIV+ persons. One hundred older HIV+ adults completed the International Physical Activity Questionnaire, a neurocognitive battery, and IADL scale. Higher levels of moderate PA were associated with lower odds of NCI (p = 0.01), even when covariates were modeled. The association between moderate PA and NCI was driven by executive function (p = 0.04). Higher levels of moderate PA were also associated with lower odds of IADL Dependence (p = 0.03), although this fell to a trend (p = 0.08) when including covariates. Follow-up analysis showed those with both NCI and IADL Dependence had lower moderate PA than those with neither (p = 0.03). While these cross-sectional findings suggest PA is associated with better neurocognitive and everyday functioning in older HIV+ adults, longitudinal studies utilizing objective PA methods are needed to evaluate directionality and mechanisms.
Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Pariya L
PL
Fazeli
Maria J
MJ
Marquine
Catherine
C
Dufour
Brook L
BL
Henry
Jessica
J
Montoya
Ben
B
Gouaux
Raeanne C
RC
Moore
Scott L
SL
Letendre
Steven Paul
SP
Woods
Igor
I
Grant
Dilip V
DV
Jeste
David J
DJ
Moore
D000203:Activities of Daily Living; D000368:Aged; D000375:Aging / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000523:psychology / Q000628:therapy*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D009483:Neuropsychological Tests; D011795:Surveys and Questionnaires