Performance Analysis of Network Model to Identify Healthy and Cancerous Colon Genes.
Modeling of cancerous and healthy Homo Sapiens colon gene using electrical network is proposed to study their behavior. In this paper, the individual amino acid models are designed using hydropathy index of amino acid side chain. The phase and magnitude responses of genes are examined to screen out cancer from healthy genes. The performance of proposed modeling technique is judged using various performance measurement metrics such as accuracy, sensitivity, specificity, etc. The network model performance is increased with frequency, which is analyzed using the receiver operating characteristic curve. The accuracy of the model is tested on colon genes and achieved maximum 97% at 10-MHz frequency.
Tanusree
T
Roy
Soma
S
Barman
D000596:Amino Acids / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics*; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry; D030541:Databases, Genetic; D004553:Electric Conductivity; D023281:Genomics / Q000379:methods*; D006801:Humans; D008957:Models, Genetic; D012372:ROC Curve
D000596:Amino Acids; D014408:Biomarkers, Tumor; D004247:DNA