The role of Ca(2+) activated Cl(-) channels in blood pressure control.
Ca(2+)-activated Cl(-) channels (CaCCs) have numerous functions in the body and are potential players in the control of blood pressure. The CaCCs represent a heterologous group including at least two protein families; TMEM16 and bestrophins. CaCCs expression has been shown in the kidney, the heart and blood vessels. Agonist-stimulated Ca(2+)-activated Cl(-) current is important for secretion in kidney epithelia, generation of a repolarizing current in the heart and amplification of excitation-contraction coupling in vascular smooth muscle cells. Changes in CaCC expression are shown in association with hypertension, kidney cysts, sudden cardiac death and arrhythmias. This review discusses recent advances in studies concerning the role of CaCC for blood pressure control with focus on the kidney, the heart and blood vessels.
Department of Biomedicine, Aarhus University, Ole Worms Allé bygn. 4, 1160 Aarhus C 8000 Denmark.
Vladimir V
VV
Matchkov
Department of Biomedicine, Aarhus University, Ole Worms Allé bygn. 4, 1160 Aarhus C 8000 Denmark.
Donna M
DM
Boedtkjer
Department of Biomedicine, Aarhus University, Ole Worms Allé bygn. 4, 1160 Aarhus C 8000 Denmark. Electronic address: ca@biomed.au.dk.
Christian
C
Aalkjaer
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001808:Blood Vessels / Q000502:physiology; D002118:Calcium / Q000502:physiology*; D018118:Chloride Channels / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology
D018118:Chloride Channels; D002118:Calcium