Cadherin-13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorder.
Several efforts have been made to find new genetic risk variants which explain the high heritability of ADHD. At the genome level, genes involved in neurodevelopmental pathways were pointed as candidates. CDH13 and CTNNA2 genes are within GWAS top hits in ADHD and there are emerging notions about their contribution to ADHD pathophysiology. The main goal of this study is to test the association between SNPs in CDH13 and CTNNA2 genes and ADHD across the life cycle in subjects with ADHD. This study included 1,136 unrelated ADHD cases and 946 individuals without ADHD. No significant association between CDH13 and CTNNA2 was observed between cases and controls across different samples (P ≥ 0.096 for all comparisons). No allele was significantly more transmitted than expected from parents to ADHD probands. The CDH13 rs11150556 CC genotype was associated with more hyperactive/impulsive symptoms in youths with ADHD (children/adolescents clinical sample: F = 7.666, P = 0.006, FDR P-value = 0.032; Pelotas Birth Cohort sample: F = 6.711, P = 0.011, FDR P-value = 0.032). Although there are many open questions regarding the role of neurodevelopmental genes in ADHD symptoms, the present study suggests that CDH13 is associated with hyperactive/impulsive symptoms in youths with ADHD.
Department of Genetics, Universidade Federal do Rio Grande do Sul, RS, Brazil.
Angélica
A
Salatino-Oliveira
Julia Pasqualini
JP
Genro
Guilherme
G
Polanczyk
Cristian
C
Zeni
Marcelo
M
Schmitz
Christian
C
Kieling
Luciana
L
Anselmi
Ana Maria Baptista
AM
Menezes
Fernando Cde
FC
Barros
Evelise Regina
ER
Polina
Nina R
NR
Mota
Eugênio Horácio
EH
Grevet
Claiton Henrique Dotto
CH
Bau
Luis Augusto
LA
Rohde
Mara Helena
MH
Hutz
D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology*; D015820:Cadherins / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics* / Q000523:psychology*; D007175:Impulsive Behavior; D008019:Life Style; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D051178:alpha Catenin / Q000235:genetics
C079671:CTNNA2 protein, human; D015820:Cadherins; C099972:H-cadherin; D051178:alpha Catenin
ADHD; CDH13; CTNNA2; cadherins; neurodevelopment