Genetic variability and phylogenetic analysis of Han population from Guanzhong region of China based on 21 non-CODIS STR loci.
In the present study, we presented the population genetic data and their forensic parameters of 21 non-CODIS autosomal STR loci in Chinese Guanzhong Han population. A total of 166 alleles were observed with corresponding allelic frequencies ranging from 0.0018 to 0.5564. No STR locus was observed to deviate from the Hardy-Weinberg equilibrium and linkage disequilibriums after applying Bonferroni correction. The cumulative power of discrimination and probability of exclusion of all the 21 STR loci were 0.99999999999999999993814 and 0.999998184, respectively. The results of genetic distances, phylogenetic trees and principal component analysis revealed that the Guanzhong Han population had a closer relationship with Ningxia Han, Tujia and Bai groups than other populations tested. In summary, these 21 STR loci showed a high level of genetic polymorphisms for the Guanzhong Han population and could be used for forensic applications and the studies of population genetics.
1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.
Yu-Dang
YD
Zhang
Department of Biochemistry, Medical college of Nanchang University, Nanchang. 330001, P. R. China.
Xiao-Li
XL
Tang
1] Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China [2] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.
Hao-Tian
HT
Meng
Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, P. R. China.
Hong-Dan
HD
Wang
1] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China [2] Department of Radiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an. 710004, P. R. China.
Rui
R
Jin
1] Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China [2] People's hospital of Arong Banner, Hulun Buir City. 162750, P. R. China.
Chun-Hua
CH
Yang
Key Laboratory of Genome Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, P. R. China.
Jiang-Wei
JW
Yan
Department of Pathology and Laboratory Medicine Loma Linda University Medical Center, California. 92354, USA.
Guang
G
Yang
Xi'an Jiaotong University Health Science Center, Xi'an 710061, P. R. China.
Wen-Juan
WJ
Liu
College of Life Sciences, Shaanxi Normal University, Xi'an. 710062, P. R. China.
Chun-Mei
CM
Shen
Research Center of Stomatology, Stomatological Hospital, Xi'an Jiaotong University, Xi'an, 710004, P. R. China.
Bo-Feng
BF
Zhu
D002681:China / Q000453:epidemiology / Q000208:ethnology; D002874:Chromosome Mapping / Q000379:methods*; D030541:Databases, Genetic; D005787:Gene Frequency / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D010802:Phylogeny; D040641:Quantitative Trait Loci / Q000235:genetics*