Wendan decoction improves learning and memory deficits in a rat model of schizophrenia.
An experimental model of schizophrenia was established using dizocilpine (MK-801). Rats were intragastrically administered with Wendan decoction or clozapine for 21 days prior to establishing the model. The results revealed that the latency of schizophrenia model rats to escape from the hidden platform in the Morris water maze was significantly shortened after administration of Wendan decoction or clozapine. In addition, the treated rats crossed the platform significantly more times than the untreated model rats. Moreover, the rate of successful long-term potentiation induction in the Wendan decoction group and clozapine group were also obviously increased compared with the model group, and the population spike peak latency was significantly shortened. These experimental findings suggest that Wendan decoction can improve the learning and memory ability of schizophrenic rats to the same extent as clozapine treatment.
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Cuiping
C
Yang
Affiliated Hospital of Jiujiang University of Jiangxi Province, Jiujiang 332000, Jiangxi Province, China.
Changchun
C
Cai
Grade 2010 Postgraduate, Medical School of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Xiaojin
X
Yang
Grade 2010 Postgraduate, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China.
Yanping
Y
Yang
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Zhigang
Z
Zhou
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Jianhua
J
Liu
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Heping
H
Ye
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Hongjiao
H
Wan
Morris water maze; Wendan decoction; hippocampus; learning and memory; long-term potentiation; neural regeneration; schizophrenia; traditional Chinese medicine