The therapeutic effects of bone marrow mesenchymal stem cells after optic nerve damage in the adult rat.
Optic nerve trauma is a common occurrence that results in irreversible blindness. Currently, no effective strategies are known to prevent optic nerve degeneration. We assessed the therapeutic effects of bone marrow mesenchymal stem cells (BMSCs) after optic nerve crush in the adult rat. Our results showed that BMSCs significantly promoted the regeneration of injured axons compared with phosphate buffered saline alone. Therefore, BMSC transplantation may be effective for the treatment of central nervous system disorders.
Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
HaiBo
H
Tan
Department of Clinical Pharmacology, Changhai Hospital Affiliated Second Military Medical University, Shanghai, People's Republic of China.
Xin
X
Kang
Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
ShiHeng
S
Lu
Department of Ophthalmology, RenJi Hospital, The School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China.
Lin
L
Liu
D000818:Animals; D001369:Axons / Q000502:physiology; D015153:Blotting, Western; D019922:GAP-43 Protein / Q000096:biosynthesis; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D009416:Nerve Regeneration; D020221:Optic Nerve Injuries / Q000628:therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D019922:GAP-43 Protein
axonal regeneration; bone marrow mesenchymal stem cell; nervous system disorders; rat optic nerve crush