Synthetic biodegradable functional polymers for tissue engineering: a brief review.
Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological concerns associated with naturally derived polymers are widely used in tissue engineering. The synthetic biodegradable polymers that are widely used in tissue engineering, including polyesters, polyanhydrides, polyphosphazenes, polyurethane, and poly (glycerol sebacate) are summarized in this article. New developments in conducting polymers, photoresponsive polymers, amino-acid-based polymers, enzymatically degradable polymers, and peptide-activated polymers are also discussed. In addition to chemical functionalization, the scaffold designs that mimic the nano and micro features of the extracellular matrix (ECM) are presented as well, and composite and nanocomposite scaffolds are also reviewed.
Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Guo
G
BaoLin
Center for Biomedical Engineering and Regenerative Medicine, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA ; Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA ; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Peter X
PX
Ma
functional polymers; scaffolds; synthetic biodegradable polymers; tissue engineering