Recent advances in proteomic studies of adipose tissues and adipocytes.
Obesity is a chronic disease that is associated with significantly increased levels of risk of a number of metabolic disorders. Despite these enhanced health risks, the worldwide prevalence of obesity has increased dramatically over the past few decades. Obesity is caused by the accumulation of an abnormal amount of body fat in adipose tissue, which is composed mostly of adipocytes. Thus, a deeper understanding of the regulation mechanism of adipose tissue and/or adipocytes can provide a clue for overcoming obesity-related metabolic diseases. In this review, we describe recent advances in the study of adipose tissue and/or adipocytes, focusing on proteomic approaches. In addition, we suggest future research directions for proteomic studies which may lead to novel treatments of obesity and obesity-related diseases.
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. issuekey@kribb.re.kr.
Eun Young
EY
Kim
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. wkkim@kribb.re.kr.|Department of Functional Genomics, University of Science and Technology of Korea, Daejeon 305-806, Korea. wkkim@kribb.re.kr.
Won Kon
WK
Kim
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. kjoh80@kribb.re.kr.
Kyoung-Jin
KJ
Oh
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. bshan@kribb.re.kr.|Department of Functional Genomics, University of Science and Technology of Korea, Daejeon 305-806, Korea. bshan@kribb.re.kr.
Baek Soo
BS
Han
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. lesach@kribb.re.kr.|Department of Functional Genomics, University of Science and Technology of Korea, Daejeon 305-806, Korea. lesach@kribb.re.kr.
Sang Chul
SC
Lee
Functional Genomics Research Center, KRIBB, Daejeon 305-806, Korea. khbae@kribb.re.kr.|Department of Functional Genomics, University of Science and Technology of Korea, Daejeon 305-806, Korea. khbae@kribb.re.kr.
Kwang-Hee
KH
Bae
D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D009765:Obesity / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
D020033:Protein Isoforms; D020543:Proteome