Potential cognitive decline linked to angiotensin-converting enzyme gene but not hypertension: Evidence from cognitive event-related potentials.
OBJECTIVE
The aims of the present study were to investigate the effect of hypertension and angiotensin-converting enzyme (ACE) genotypes on cognitive event-related potentials (ERPs), and whether the impact of ACE genotypes on P300 is related to the influence of hypertension.


METHODS
Using the Cognitive Abilities Screening Instrument (CASI), we recruited 97 mentally healthy middle-aged and older adults. Medical histories were collected, and blood pressure, ACE insertion/deletion polymorphisms and ERPs in an auditory oddball task were measured for all participants.


RESULTS
When the participants were stratified according to the presence or absence of hypertension, there were no differences in CASI score, percentage of ACE genotypes and ERPs. The subjects with the D/D homozygote displayed lower amplitude and longer latency of P300, although there were no differences in CASI score and the percentage of hypertension.


CONCLUSIONS
The subjects with the D/D genotype tended to have decreased amplitude and prolonged latency of P300 ERPs which reflected subtle cognitive impairment. There were no associations between hypertension, CASI score and P300 measurements.


CONCLUSIONS
Using ERPs, potential cognitive decline was linked to ACE genotypes, independently of the effect of hypertension.
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Taiwan.
Li-Min
LM
Liou
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Taiwan.
Yuan-Han
YH
Yang
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Taiwan.
Shiang-Ru
SR
Lu
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Taiwan.
Chung-Yao
CY
Hsu
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Taiwan.
Ching-Kuan
CK
Liu
Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Taiwan. Electronic address: cllai@kmu.edu.tw.
Chiou-Lian
CL
Lai
D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D018913:Event-Related Potentials, P300 / Q000235:genetics*; D019317:Evidence-Based Medicine / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
Angiotensin-converting enzyme gene; Cognitive event-related potentials; Hypertension; P300