Antibacterial alkaloids from Artabotrys crassifolius Hook.f. & Thomson.
Chloroform extract of bark of Artabotrys crassifolius Hook.f. & Thomson exhibited antibacterial activities against both American Type Culture Collection and clinical bacterial strains in vitro with zones of inhibition ranging from 7 to 14 mm. Further analysis of this extract yielded artabotrine, liridine, lysicamine and atherospermidine. Artabotrine displayed a broad array of antibacterial activity mostly against Gram-positive bacteria with minimum inhibitory concentration (MIC) values ranging from 1.25 μg/mL to 5 μg/mL. Of note, artabotrine, liridine and lysicamine are bactericidal against Gram-negative extended-spectrum beta-lactamase-producing Klebsiella with MIC values equal 2.5, 2.5 and 10 μg/mL, respectively, and minimum bactericidal concentrations values equal to 2.5, 5 and 20 μg/mL.
a School of Pharmacy, Faculty of Sciences, University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor Darul Ehsan , Malaysia.
Kok Kwan
KK
Tan
a School of Pharmacy, Faculty of Sciences, University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor Darul Ehsan , Malaysia.
Teng Jing
TJ
Khoo
b School of Pharmacy, Faculty of Pharmaceutical Sciences, UCSI University Kuala Lumpur Campus (South Wing) , No 1 Jln Menara Gading, UCSI Heights, Cheras 56000 Kuala Lumpur , Malaysia.
Mogana
M
Rajagopal
a School of Pharmacy, Faculty of Sciences, University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor Darul Ehsan , Malaysia.
Christophe
C
Wiart
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D029061:Annonaceae / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D001060:Aporphines; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001060:Aporphines; D010936:Plant Extracts; C000604055:artabotrine; C000604056:liridine; C069090:lysicamine; C064684:atherospermidine
Artabotrys crassifolius Hook.f; Klebsiella; alkaloids; antibacterial