[Childhood obesity is associated to the interaction between firmicutes and high energy food consumption].
INTRODUCTIÓN: Obesity is a serious public health problem in Mexico, the National Health and Nutrition Survey (ENSANUT 2012) reported a 34.4% prevalence of overweight, and obesity in children aged 5-11. Recent research has suggested that the gut microbiota may be a risk factor of obesity through its influence on human metabolism.


OBJECTIVE
To evaluate association between the intestinal microbiota profile and obesity among children and whether this association is modified depending on the feeding pattern of a sample of schoolchildren from Mexico City. METODOLOGY AND RESULTS: Cross-sectional study on 1042 children aged 6-14 years; physical activity questionnaire, personal medical history and heredofamilial of obesity and type 2 diabetes were administered to all the children. Eating patterns was performed by principal component analysis (PCA). The association between intestinal microbiota and overweight / obesity depending on diet was assessed with logistic regression models.


CONCLUSIONS
Our results shows that the interaction between the intestinal microbiota and diet, particularly high in fats and simple carbohydrates increases the chance of developing obesity.
Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mor., México.. barbix_mx@yahoo.com.
Barbara Ixchel
BI
Estrada-Velasco
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, CMN Siglo XXI, Ciudad de México, México.. mcruzl@yahoo.com.
Miguel
M
Cruz
Departamento de Genetica y Biologia Molecular, Cinvestav-IPN, México, DF, Mexico.. jgmena@cinvestav.mx.
Jaime
J
Garcia-Mena
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, CMN Siglo XXI, Ciudad de México, México.. adanval@gmail.com.
Adan
A
Valladares Salgado
Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades, IMSS, CMN Siglo XXI, Ciudad de México, México.. drjperalta@hotmail.com.
Jesus
J
Peralta Romero
Servicio de Microbiología, Hospital General Universitario y Facultad de Medicina, Universidad de Valencia, Valencia, España. reme.guna@gmail.com.
Maria de Los Remedios
Mde L
Guna Serrano
Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mor., México.. vmarina@insp.mx.
Vicente
V
Madrid-Marina
Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mor., México.. jcitla_oro@hotmail.com.
Citlalli
C
Orbe Orihuela
Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mor., México.. jcitla_oro@hotmail.com.
Claudia
C
López Islas
Centro de investigación sobre enfermedades infecciosas, Instituto Nacional de Salud Pública, Cuernavaca, Mor., México.. aburguete@insp.mx.
Ana Isabel
AI
Burguete-García
D000293:Adolescent; D000886:Anthropometry; D015373:Bacterial Typing Techniques; D001439:Bacteroides / Q000302:isolation & purification / Q000502:physiology; D002648:Child; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D004032:Diet; D004040:Dietary Carbohydrates / Q000009:adverse effects; D004041:Dietary Fats / Q000009:adverse effects; D004435:Eating; D002149:Energy Intake; D005247:Feeding Behavior; D005260:Female; D006094:Gram-Positive Bacteria / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D008297:Male; D064307:Microbiota; D009043:Motor Activity; D009765:Obesity / Q000453:epidemiology / Q000209:etiology*; D012959:Socioeconomic Factors
D004040:Dietary Carbohydrates; D004041:Dietary Fats