Intranasal dexmedetomidine for sedation for pediatric computed tomography imaging.
This prospective observational pilot study evaluated the aerosolized intranasal route for dexmedetomidine as a safe, effective, and efficient option for infant and pediatric sedation for computed tomography imaging. The mean time to sedation was 13.4 minutes, with excellent image quality, no failed sedations, or significant adverse events.


BACKGROUND
Registered with ClinicalTrials.gov: NCT01900405.
Pediatric Emergency Department, University Hospital, University of Sao Paulo and Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Eduardo
E
Mekitarian Filho
DM-Stat, Inc, Malden, MA.
Fay
F
Robinson
Department of Pediatrics, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Werther Brunow
WB
de Carvalho
Pediatric Emergency Department, University Hospital, University of Sao Paulo, Sao Paulo, Brazil.
Alfredo Elias
AE
Gilio
Department of Anesthesia, Harvard Medical School, Children's Hospital Boston, Boston, MA. Electronic address: keira.mason@childrens.harvard.edu.
Keira P
KP
Mason
D000281:Administration, Intranasal; D000336:Aerosols; D002675:Child, Preschool; D016292:Procedural Sedation / Q000379:methods*; D020927:Dexmedetomidine / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D007223:Infant; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed
D000336:Aerosols; D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine