Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism.
Neonatal immune hyperthyroidism is a rare but potentially fatal condition. It occurs in 1-5% of infants born to women with Graves' disease (GD). In most of the cases it is due to maternal antibodies transferred from the mother into the fetal compartment, stimulating the fetal thyroid by binding thyrotropin (thyroid-stimulating hormone, TSH) receptor. We present a case of neonatal thyrotoxicosis due to maternal GD detected at 25 days of age and discuss the potential pitfalls in the diagnosis.
Departamento de Pediatria Médica, Hospital Dona Estefânia, Lisboa, Portugal.
Miguel Fragata
MF
Correia
Departamento da Mulher e da Criança, HPP Hospital de Cascais Dr José de Almeida, Alcabideche, Portugal.
Ana Teresa
AT
Maria
Departamento da Mulher e da Criança, HPP Hospital de Cascais Dr José de Almeida, Alcabideche, Portugal.
Sara
S
Prado
Unidade de Endocrinologia, Hospital Dona Estefânia, Lisboa, Portugal.
Catarina
C
Limbert
D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D007454:Iodides / Q000627:therapeutic use; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D011433:Propranolol / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*
D013956:Antithyroid Agents; D007454:Iodides; D008713:Methimazole; D011433:Propranolol; C010389:Lugol's solution