CD95 rs1800682A/G variant and tumor risk in Asians: evidence from a meta-analysis of 36 case-control studies containing 22,438 samples.
BACKGROUND
The CD95 gene plays a key role in regulating cell growth and tumor genesis. To date, several publications have focused on the CD95 rs1800682A/G site polymorphism and various types of tumors in Asians; however, this association is still controversial and obscure. Therefore, a meta-analysis combined with all publications to clarify this association is necessary.


METHODS
A search in the PubMed and SinoMed databases was performed to detect all relevant included publications. Odds ratio (OR) and 95% confidence intervals (CI) revealed association strengths.


RESULTS
Overall, 36 case-control studies were chosen based on the search criteria. There was no association of the CD95 rs1800682A/G site polymorphism with tumor risk in total and ethnicity subgroup analysis. However, further stratified analysis in the cancer subgroup revealed weakly significant associations in hepatocellular carcinoma (AA+AG vs. GG: OR=0.93, 95% CI=0.87-0.99, P=0.035; AG vs. GG: OR=0.89, 95% CI=0.80-0.99, P=0.036).


CONCLUSIONS
The CD95 rs1800682A/G site polymorphism may be associated with hepatocellular carcinoma susceptibility. Further large-scale and well-designed studies regarding tumor types and ethnicities are still required to confirm our results.
Department of Hepatobiliary Pancreatic Center, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Cheng
C
Jin
Department of Oncology, Wuxi No. 4 People's Hospital, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China (mainland).
Xiaomin
X
Wu
Department of Hepatobiliary Pancreatic Center, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Yuanlong
Y
Gu
Department of Hepatobiliary Pancreatic Center, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Fenglai
F
Yuan
Liver Cancer Institute and Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China (mainland).
Qinghai
Q
Ye
Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Feng
F
Dai
Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Lijie
L
Zhu
Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi, Jiangsu, China (mainland).
Yuanyuan
Y
Mi
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors; D019014:fas Receptor / Q000235:genetics*
C491901:FAS protein, human; D019014:fas Receptor