A new approach to oxidative stress and inflammatory signaling during labour in healthy mothers and neonates.
The objective of the current study was to investigate for the first time and simultaneously the oxidative stress and inflammatory signaling induced during the delivery in healthy mothers and their neonates. 56 mothers with normal gestational course and spontaneous delivery were selected. Blood samples were taken from mother (before and after delivery) both from vein and artery of umbilical cord. Lower antioxidant enzymes activities were observed in neonates compared with their mothers and lower oxidative stress in umbilical cord artery with respect to vein. There was an overexpression of inflammatory cytokines in the mother, such as IL-6 and TNF-α, and, in addition, PGE2 was also increased. Neonates showed lower levels of IL-6 and TNF-α and higher values of sTNF-RII and PGE2 in comparison with their mothers. Parturition increases oxidative damage in the mother, although the indicators of oxidative damage were lower in umbilical cord artery with respect to umbilical vein. The overexpression of inflammatory cytokines reveals that fetus suffers its own inflammatory process during parturition.
Department of Physiology, University of Granada, 18071 Granada, Spain ; Institute of Nutrition and Food Technology "José Mataix", University of Granada, 18071 Granada, Spain.
Javier
J
Díaz-Castro
Department Obtetrics and Gynecology, School of Medicine, University of Granada, 18071 Granada, Spain ; Service of Obstetrics and Gynecology, University Hospital San Cecilio, 18071 Granada, Spain.
Jesus
J
Florido
Department of Physiology, University of Granada, 18071 Granada, Spain ; Institute of Nutrition and Food Technology "José Mataix", University of Granada, 18071 Granada, Spain.
Naroa
0000-0002-2364-1359
N
Kajarabille
Department Obtetrics and Gynecology, School of Medicine, University of Granada, 18071 Granada, Spain ; Service of Obstetrics and Gynecology, University Hospital San Cecilio, 18071 Granada, Spain.
Sonia
S
Prados
Department Obtetrics and Gynecology, School of Medicine, University of Granada, 18071 Granada, Spain ; Service of Obstetrics and Gynecology, University Hospital San Cecilio, 18071 Granada, Spain.
Catalina
C
de Paco
Department Obtetrics and Gynecology, School of Medicine, University of Granada, 18071 Granada, Spain ; Service of Obstetrics and Gynecology, University Hospital San Cecilio, 18071 Granada, Spain.
Olga
O
Ocon
Department of Physiology, University of Granada, 18071 Granada, Spain ; Institute of Nutrition and Food Technology "José Mataix", University of Granada, 18071 Granada, Spain.
Mario
M
Pulido-Moran
Department of Physiology, University of Granada, 18071 Granada, Spain ; Institute of Nutrition and Food Technology "José Mataix", University of Granada, 18071 Granada, Spain.
Julio J
JJ
Ochoa
D000328:Adult; D002374:Catalase / Q000378:metabolism; D015232:Dinoprostone / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005865:Gestational Age; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000378:metabolism*; D007743:Labor, Obstetric; D009035:Mothers; D018384:Oxidative Stress; D011247:Pregnancy; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D015232:Dinoprostone