I₂-TBHP-catalyzed oxidative cross-coupling of N-sulfonyl hydrazones and isocyanides to 5-aminopyrazoles.
I2-TBHP-catalyzed oxidative cross coupling of N-sulfonyl hydrazones with isocyanides has been realized for the synthesis of 5-aminopyrazoles through formal [4 + 1] annulation via in situ azoalkene formation. Notable features are the metal/alkyne-free strategy, C-C and C-N bond formation, atom economy, catalytic I2, broad functional group tolerance, good reaction yields, shorter time, and also applicability to one-pot methodology.
†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Gopal Chandru
GC
Senadi
‡Department of Biotechnology, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Wan-Ping
WP
Hu
†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Ting-Yi
TY
Lu
†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Amol Milind
AM
Garkhedkar
†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Jaya Kishore
JK
Vandavasi
†Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, No. 100, Shih-Chuan First Rd, Sanmin District, Kaohsiung City, 807, Taiwan.
Jeh-Jeng
JJ
Wang