title: Transplanted human umbilical cord mesenchymal stem cells facilitate lesion repair in B6.Fas mice.
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies. No effective treatment for SLE currently exists.
  
  
  METHODS
  We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.
  
  
  RESULTS
  After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls. The percentage of CD4(+)CD25(+)Foxp3(+) T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.
  
  
  CONCLUSIONS
  The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Guang-ping
authors.initials: GP
authors.lastname: Ruan
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Yao
authors.affiliation: Kunming Biological Diversity Regional Center of Large Apparatus and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
authors.forename: Shuang-juan
authors.initials: SJ
authors.lastname: Yang
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Jin-xiang
authors.initials: JX
authors.lastname: Wang
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Shu
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Zi-an
authors.initials: ZA
authors.lastname: Li
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Ju-fen
authors.initials: JF
authors.lastname: Liu
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Rong-qing
authors.initials: RQ
authors.lastname: Pang
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China.
authors.forename: Xing-hua
authors.initials: XH
authors.lastname: Pan
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood; D015704:CD4 Antigens / Q000378:metabolism; D004247:DNA / Q000276:immunology; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006657:Histones / Q000276:immunology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D018655:Lymphocyte Count; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014183:Transplantation, Heterologous; D014470:Umbilical Cord / Q000166:cytology*
chemical_list: D000974:Antibodies, Antinuclear; D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D006657:Histones; D053645:Interleukin-2 Receptor alpha Subunit; D004247:DNA