title: Thyroid function is associated with insulin resistance markers in healthy adolescents with risk factors to develop diabetes.
abstract: BACKGROUND
  The prevalence of obesity and Type 2 diabetes mellitus (T2DM) among children and adolescents is rising. Thyroid function has been associated with insulin resistance. There is scarce information about how thyroid function could be related with cardiovascular risk or glucose homeostasis in adolescent.
  
  
  OBJECTIVE
  To analyze how thyroid function is associated with insulin resistance and another cardiovascular risk factors in healthy adolescents with risk factors to develop diabetes.
  
  
  METHODS
  A prospective cross-sectional analysis was carried out on euthyroid, adolescents. considered at high risk to develop Type 2 diabetes. Fasting blood samples were obtained. Thyroid function test and another cardiometabolic parameters were assessed. A 75 grams oral glucose tolerance test was performed to calculate insulin resistance.
  
  
  RESULTS
  One hundred adolescents were evaluated. The mean age was 15.9 ± 0.8 years, There is a negative correlation between Fasting insulin, post glucose load insulin and HOMA IR. There were no correlation with Matsuda index. We could not found any correlation with TSH values.
  
  
  CONCLUSIONS
  We found a correlation between fasting insulin, HOMA IR and serum thyroid hormones, we did not find any relation with serum TSH. In euthyroid adolescents with risk factors to develop diabetes.
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de Salud del Universitario, 50226 Toluca, State of Mexico Mexico ; Coordinación de Investigación en Salud, Delegación México Poniente de Instituto Mexicano del Seguro Social, 50226 Toluca, State of Mexico Mexico.
authors.forename: José de Jesús
authors.initials: Jde J
authors.lastname: Garduño-Garcia
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de Salud del Universitario, 50226 Toluca, State of Mexico Mexico.
authors.forename: Eneida
authors.initials: E
authors.lastname: Camarillo Romero
authors.affiliation: High school Licenciado Adolfo López Mateos, 50226 Toluca, State of Mexico Mexico.
authors.forename: Ana
authors.initials: A
authors.lastname: Loe Ochoa
authors.affiliation: Coordinación de Investigación en Salud, Delegación México Poniente de Instituto Mexicano del Seguro Social, 50226 Toluca, State of Mexico Mexico.
authors.forename: Socorro
authors.initials: S
authors.lastname: Romero-Figueroa
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de Salud del Universitario, 50226 Toluca, State of Mexico Mexico.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Huitron Bravo
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de Salud del Universitario, 50226 Toluca, State of Mexico Mexico.
authors.forename: Roció
authors.initials: R
authors.lastname: Torres García
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de Salud del Universitario, 50226 Toluca, State of Mexico Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Montenegro-Morales
authors.affiliation: Medical Sciences Research Center (CICMED) Cuerpo académico de biomedicina, 50226 Toluca, State of Mexico Mexico.
authors.forename: Hugo
authors.initials: H
authors.lastname: Mendieta-Zerón
keywords: Diabetes; Insulin resistance; Thyroid