title: A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug.
abstract: Due to their high NIR-optical absorption and high specific surface area, graphene oxide and graphene oxide-based nanocomposites have great potential in both drug delivery and photothermal therapy. In the work reported herein we successfully integrate a Pt(IV) complex (c,c,t-[Pt(NH3)2Cl2(OH)2]), PEGylated nano-graphene oxide (PEG-NGO), and a cell apoptosis sensor into a single platform to generate a multifunctional nanocomposite (PEG-NGO-Pt) which shows potential for targeted drug delivery and combined photothermal-chemotherapy under near infrared laser irradiation (NIR), and real-time monitoring of its therapeutic efficacy. Non-invasive imaging using a fluorescent probe immobilized on the GO shows an enhanced therapeutic effect of PEG-NGO-Pt in cancer treatment via apoptosis and cell death. Due to the enhanced cytotoxicity of cisplatin and the highly specific tumor targeting of PEG-NGO-Pt at elevated temperatures, this nanocomposite displays a synergistic effect in improving the therapeutic efficacy of the Pt drug with complete destruction of tumors, no tumor recurrence and minimal systemic toxicity in comparison with chemotherapy or photothermal treatment alone, highlighting the advantageous effects of integrating Pt(IV) with GO for anticancer treatment.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Lyv
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Liu
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Jinkui
authors.initials: J
authors.lastname: Wang
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhan
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. Electronic address: chenh@suda.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China. Electronic address: chenhb@suda.edu.cn.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China. Electronic address: xinmingli@suda.edu.cn.
authors.forename: Xinming
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D016923:Cell Death; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004357:Drug Synergism; D005260:Female; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry; D009928:Organ Specificity / Q000187:drug effects; D010087:Oxides / Q000737:chemistry*; D010789:Phototherapy; D010984:Platinum / Q000494:pharmacology / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011355:Prodrugs / Q000494:pharmacology / Q000627:therapeutic use*; D013050:Spectrometry, Fluorescence; D000068936:Theranostic Nanomedicine; D023041:Xenograft Model Antitumor Assays
chemical_list: D010087:Oxides; D011355:Prodrugs; D011092:Polyethylene Glycols; D010984:Platinum; D006108:Graphite
keywords: Graphene oxide; Photothermal; Pt(IV); Synergistic; Theranostic