title: [Effects of guizhi fuling capsule on sex hormone levels and breast issue morphology of mammary gland hyperplasia model rats].
abstract: OBJECTIVE
  To research the effects of Guizhi Fuling capsule on sex hormones levels in blood serum and breast issue morphology of hyperplasia of mammary glands model rats.
  
  
  METHODS
  The unpregnancy SD rat models of hyperplasia of mammary glands were established by injecting 0.5 mg x kg(-1) benzoate estradiol. After five weeks doses,the effects of Guizhi Fuling capsule 2.0, 1.0, 0.5 g x kg(-1) and Rupixiao tablet 0.5 g x kg(-1) on the changes of papilla diameter, height and breast issue morphology of the naimal models were explored, and sex hormones levels in blood serum were measured.
  
  
  RESULTS
  Guizhi Fuling capsule can inhibitnipple swell, improve breast tissue morphology pathological profiles of the animal models, and decrease oestradiol (E2) level and increase progesterone (P) level in blood serum.
  
  
  CONCLUSIONS
  These results suggested that Guizhi Fuling capsule could, improve mammary gland pathological profiles. Regulating sex hormone levels may be its important mechanism for treatment of hyperplasia of mammary glands.
authors.forename: Xiu-juan
authors.initials: XJ
authors.lastname: Chang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Chun-miao
authors.initials: CM
authors.lastname: Chen
authors.forename: Zhen-zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology*; D051381:Rats
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D012739:Gonadal Steroid Hormones; C525079:guizhi-fuling