title: Interferon-γ-inducible chemokines in systemic lupus erythematosus.
abstract: Some studies reported that chemokine interferon-γ-inducible protein 10 (IP-10) and its receptor chemokine (C-X-C motif) receptor (CXCR) 3, which is exhibited by T cells, are expressed in several types of cutaneous damages associated with Systemic Lupus Erythematosus (SLE), and that the CXCR3-activating chemokines are produced locally, suggesting their significant role in the recruitment of T cells in these inflammatory lesions. The involvement of IP-10 and CXCR3 has been shown also in several other types of tissue damages associated with SLE, such as glomerulonephritis or central nervous system lupus. Urinary IP-10 is a sensitive and non-invasive diagnostic tool for monitoring lupus nephritis patients, and the response to treatments. Serum levels of IP-10 are increased in SLE patients, showing a strong correlation with disease activity. Levels of IP-10 are also increased in the cerebrospinal fluid samples from neuropsychiatric SLE patients. These data provide increasing evidence that IP-10 may participate in the pathogenesis of a variety of the manifestations of SLE, even if the exact role of IP-10 in the pathogenesis of SLE remains to be clarified.
authors.affiliation: Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Elia
mesh_terms: D002555:Cerebrospinal Fluid / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism*; D019744:Chemokines, C; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D020945:Lupus Vasculitis, Central Nervous System / Q000503:physiopathology; D008297:Male; D054367:Receptors, CXCR3 / Q000378:metabolism*
chemical_list: C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D019744:Chemokines, C; D054367:Receptors, CXCR3
keywords: CXCR3; IP-10; Systemic Lupus Erythematosus