title: Pharmacological classes that extend lifespan of Caenorhabditis elegans.
abstract: Recent progress in the field of aging has resulted in ever increasing numbers of compounds that extend lifespan in Caenorhabditis elegans. Lifespan extending compounds include metabolites and synthetic compounds, as well as natural products. For many of these compounds, mammalian pharmacology is known, and for some the actual targets have been experimentally identified. In this review, we explore the data available in C. elegans to provide an overview of which pharmacological classes have potential for identification of further compounds that extend lifespan.
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Experimental Medicine, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Cellular Neuroscience, The Scripps Research Institute , La Jolla, CA, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Carretero
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Experimental Medicine, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Cellular Neuroscience, The Scripps Research Institute , La Jolla, CA, USA.
authors.forename: Rafael L
authors.initials: RL
authors.lastname: Gomez-Amaro
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Experimental Medicine, The Scripps Research Institute , La Jolla, CA, USA ; Department of Molecular and Cellular Neuroscience, The Scripps Research Institute , La Jolla, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Petrascheck
keywords: Caenorhabditis elegans; GPCR; aging; dietary restriction mimetics; drug discovery; lifespan; pharmacology