title: Efficacy of musical interventions in dementia: methodological requirements of nonpharmacological trials.
abstract: The management of patients with Alzheimer's disease is a significant public health problem given the limited effectiveness of pharmacological therapies combined with iatrogenic effects of drug treatments in dementia. Consequently, the development of nondrug care, such as musical interventions, has become a necessity. The experimental rigor of studies in this area, however, is often lacking. It is therefore difficult to determine the impact of musical interventions on patients with dementia. As part of a series of studies, we carried out randomized controlled trials to compare the effectiveness of musical activities to other pleasant activities on various functions in patients with severe Alzheimer's disease. The data obtained in these trials are discussed in light of the methodological constraints and requirements specific to these clinical studies. Although the results demonstrate the power of music on the emotional and behavioral status of patients, they also suggest that other pleasant activities (e.g., cooking) are also effective, leaving open the question about the specific benefits of music in patients with dementia. All these findings highlight the promising potential for nonpharmacological treatments to improve the well-being of patients living in residential care and to reduce caregiver burden.
authors.affiliation: Equipe Neuropsychologie: Audition, Cognition et Action (EA 4072), UFR de psychologie, Université Lille-Nord de France, Villeneuve d'Ascq, France; Unité d'épilepsie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Séverine
authors.initials: S
authors.lastname: Samson
authors.forename: Sylvain
authors.initials: S
authors.lastname: Clément
authors.forename: Pauline
authors.initials: P
authors.lastname: Narme
authors.forename: Loris
authors.initials: L
authors.lastname: Schiaratura
authors.forename: Nathalie
authors.initials: N
authors.lastname: Ehrlé
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology / Q000628:therapy*; D001519:Behavior; D017028:Caregivers; D003071:Cognition; D003704:Dementia / Q000503:physiopathology / Q000628:therapy*; D004644:Emotions; D006801:Humans; D009146:Music; D009147:Music Therapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results; D012107:Research Design; D016896:Treatment Outcome
keywords: Alzheimer's disease; emotion; music; nonpharmacological treatment; randomized controlled trial