title: [Action of yttrium on calcium-dependent processes in myocardium of vertebrates].
abstract: This work deals with study, of effect of yttrium acetate (Y3+) on myocardium of the frog Rana redibunda and of its action on the ion transport across the inner membrane of the rat heart mitochondria. It was found that Y3+ decreased strength of heart contractions and facilitated transport of ions in rat heart mitochondria stimulated by 10 mM glutamate and 2 mM malate. In the presence of Y3+, the energy-dependent transport of Ca2+ in mitochondria was inhibited; this was manifested as a decrease of their swelling in the medium containing 125 mM NH4NO3 and Ca2+ or 25 mM potassium acetate, 100 mM sucrose and Ca2+. It is assumed that the Y(3+)-caused decrease of the heart muscle contractility is not only due to its direct blocking effect on the potential-operated Ca2+ channels of the pacemaker and contractile cardiomyocytes, but also due to its mediated action on active transport of Ca2+ in mitochondria. The data that Y3+ activates transport of K+ via the mitochondrial potassium uniporter and blocks Ca(2+)-channels of the inner mitochondrial membrane are important for better understanding of mechanisms of action Y3+ on cardiomyocytes of vertebrate animals and humans and the possible use of Y3+ in medicine.
authors.forename: I V
authors.initials: IV
authors.lastname: Shemarova
authors.forename: C V
authors.initials: CV
authors.lastname: Sobol
authors.forename: S M
authors.initials: SM
authors.lastname: Korotkov
authors.forename: V P
authors.initials: VP
authors.lastname: Nesterov
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D018698:Glutamic Acid / Q000494:pharmacology; D008293:Malates / Q000494:pharmacology; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D015221:Potassium Channels / Q000378:metabolism; D011898:Ranidae; D015019:Yttrium / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008293:Malates; D015221:Potassium Channels; D018698:Glutamic Acid; D015019:Yttrium; C030298:malic acid; D002118:Calcium