title: Relationship between 11β-HSD2 mRNA and insulin sensitivity in term small-for-gestational age neonates after birth.
abstract: The aim of this study was to investigate the relationship between serum 11β-HSD2 mRNA level and insulin sensitivity in term small-for-gestational age (SGA) neonates after birth. The 38 infants were divided into two groups, the SGA group and the appropriate-for-gestational age (AGA) group. The placental 11β-HSD2 mRNA abundance and concentration of cortisol, fasting glucose, fasting insulin, adiponectin, visfatin and insulin-like growth factor-I (IGF-1) in the umbilical vein plasma were measured. The results showed that in the SGA group, neonates had lower levels of placental 11β-HSD2 mRNA and serum cortisol, and higher fasting insulin and HOMA-IR compared to AGA group. For some insulin sensitivity relative factor, levels of serum adiponectin and IGF-1 were lower while visfatin was higher in the SGA group than AGA group. Correlation analyses revealed that 11β-HSD2 mRNA level had a negative correlation with fasting insulin, HOMA-IR and visfatin.
authors.affiliation: Department of Endocrinology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Vice-Chief Physician 72 Guangzhou Road, Nanjing 210008, Jiangsu Province.
authors.forename: Ziyang
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Vice-Chief Physician 72 Guangzhou Road, Nanjing 210008, Jiangsu Province.
authors.forename: Qianqi
authors.initials: Q
authors.lastname: Liu
mesh_terms: D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2 / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D052242:Adiponectin; D012333:RNA, Messenger; D043209:11-beta-Hydroxysteroid Dehydrogenase Type 2; C468387:HSD11B2 protein, human; D054409:Nicotinamide Phosphoribosyltransferase
keywords: 11β-HSD2; SGA; insulin sensitivity; neonates; term