title: A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences.
abstract: Nowadays, in many communities, there is a growing concern about possible adverse effects of pesticides on human health. Reports indicate that during environmental or occupational exposure, pesticides can exert some intense adverse effects on human health through transient or permanent alteration of the immune system. There is evidence on the relation between pesticide-induced immune alteration and prevalence of diseases associated with alterations of the immune response. In the present study, direct immunotoxicity, endocrine disruption and antigenicity have been introduced as the main mechanisms working with pesticides-induced immune dysregulation. Moreover, the evidence on the relationship between pesticide exposure, dysregulation of the immune system and predisposition to different types of psychiatric disorders, cancers, allergies, autoimmune and infectious diseases are criticized.
authors.affiliation: a Department of Immunology, Faculty of Medicine , Cellular and Molecular Research Center, Kurdistan University of Medical Sciences , Sanandaj , Iran and.
authors.forename: Aram
authors.initials: A
authors.lastname: Mokarizadeh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Faryabi
authors.forename: Mohammad Amin
authors.initials: MA
authors.lastname: Rezvanfar
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
mesh_terms: D000818:Animals; D052244:Endocrine Disruptors / Q000633:toxicity; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D016273:Occupational Exposure / Q000009:adverse effects; D010575:Pesticides / Q000633:toxicity*
chemical_list: D052244:Endocrine Disruptors; D010575:Pesticides
keywords: Allergy; autoimmune disease; cancer; immune alteration; infectious disease; pesticide; psychiatric disorder; review