title: Protein design: Past, present, and future.
abstract: Building on the pioneering work of Ho and DeGrado (J Am Chem Soc 1987, 109, 6751-6758) in the late 1980s, protein design approaches have revealed many fundamental features of protein structure and stability. We are now in the era that the early work presaged - the design of new proteins with practical applications and uses. Here we briefly survey some past milestones in protein design, in addition to highlighting recent progress and future aspirations.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.|Department of Chemistry, Yale University, New Haven, CT.|Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT.
authors.forename: Lynne
authors.initials: L
authors.lastname: Regan
authors.affiliation: Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT.|Department of Physics, Yale University, New Haven, CT.
authors.forename: Diego
authors.initials: D
authors.lastname: Caballero
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Hinrichsen
authors.affiliation: Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT.|Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Virrueta
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Williams
authors.affiliation: Integrated Graduate Program in Physical and Engineering Biology, Yale University, New Haven, CT.|Department of Physics, Yale University, New Haven, CT.|Department of Mechanical Engineering and Materials Science, Yale University, New Haven, CT.|Department of Applied Physics, Yale University, New Haven, CT.
authors.forename: Corey S
authors.initials: CS
authors.lastname: O'Hern
mesh_terms: D000818:Animals; D006801:Humans; D015202:Protein Engineering / Q000379:methods* / Q000639:trends
keywords: computation; nanotechnology; protein design; review