title: Structure-function relationships of glycoprotein hormones and their subunits' ancestors.
abstract: Glycoprotein hormones (GPHs) are the most complex molecules with hormonal activity. They exist only in vertebrates but the genes encoding their subunits' ancestors are found in most vertebrate and invertebrate species although their roles are still unknown. In the present report, we review the available structural and functional data concerning GPHs and their subunits' ancestors.
authors.affiliation: Physiologie de la Reproduction et des Comportements (PRC), Centre National de la Recherche Scientifique, INRA , Nouzilly , France.
authors.forename: Claire
authors.initials: C
authors.lastname: Cahoreau
authors.affiliation: Physiologie de la Reproduction et des Comportements (PRC), Centre National de la Recherche Scientifique, INRA , Nouzilly , France.
authors.forename: Danièle
authors.initials: D
authors.lastname: Klett
authors.affiliation: Physiologie de la Reproduction et des Comportements (PRC), Centre National de la Recherche Scientifique, INRA , Nouzilly , France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Combarnous
keywords: evolution; follicle-stimulating hormone; glycoprotein hormones; luteinizing hormone; molecular; structure–activity relationship; thyroid-stimulating hormone