title: Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents.
abstract: Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune - 411041, Maharashtra, India. d_pras_anna@rediffmail.com.
authors.forename: Prasanna A
authors.initials: PA
authors.lastname: Datar
authors.forename: Saleel A
authors.initials: SA
authors.lastname: Limaye
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage; D000700:Analgesics / Q000008:administration & dosage / Q000138:chemical synthesis*; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000737:chemistry*; D004008:Diclofenac / Q000008:administration & dosage* / Q000737:chemistry; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced / Q000517:prevention & control*; D007249:Inflammation / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008352:Mannich Bases / Q000138:chemical synthesis*; D051379:Mice; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D001562:Benzimidazoles; D008352:Mannich Bases; D004008:Diclofenac; C031000:benzimidazole; D019342:Acetic Acid