title: PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.
abstract: Platelet activating factor (PAF), a potent pro-inflammatory phospholipid, has been found to trigger tumor growth and angiogenesis through its G-protein coupled receptor (PAFR). This study was aimed to investigate the potential role of PAF in azoxymethane (AOM)/dextran sulfate sodium (DSS) induced colitis-associated cancer (CAC), using PAFR antagonist Ginkgolide B (GKB). We found GKB up-regulated serum level of PAF-AH activity. As assessed by disease activity index (DAI), histological injury scores, leukocytes infiltration, and expression of pro-inflammatory cytokines, GKB ameliorated colonic inflammation and decreased tumor number and load in mice. GKB also decreased expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in tumor. These results suggest that PAFR antagonist might be a potential therapeutic strategy for CAC.
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Jia
authors.initials: J
authors.lastname: Ke
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Senmao
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Xianrui
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Lian
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Jiancong
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zou
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Colorectal Surgery, Sixth Affiliated Hospital, Sun Yat-Sen University Guangzhou City, Guangdong Province, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Lan
mesh_terms: D000818:Animals; D001397:Azoxymethane; D063646:Carcinogenesis / Q000187:drug effects* / Q000473:pathology; D003092:Colitis / Q000139:chemically induced / Q000473:pathology*; D016264:Dextran Sulfate; D005260:Female; D046934:Ginkgolides / Q000494:pharmacology / Q000627:therapeutic use*; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*
chemical_list: D046934:Ginkgolides; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D016264:Dextran Sulfate; C045856:ginkgolide B; D001397:Azoxymethane
keywords: Ginkgolide B; PAF; VEGF; angiogenesis; colitis-associated cancer