title: The role of asymmetric and symmetric dimethylarginine in acute deep vein thrombosis.
abstract: BACKGROUND
  In this study, we aimed to determine the importance of asymmetric dimethylarginine (ADMA), symmetric dimethyl arginine (SDMA), and l-arginine levels which are influenced by the endothelial dysfunction in acute deep vein thrombosis (DVT), and compare their pretreatment and post-treatment levels.
  
  
  METHODS
  A total of 34 cases (19 men and 15 women, age range 42 ± 14 years) diagnosed with acute DVT and 34 control subjects (22 men and 12 women, age range 45 ± 11 years) without any vascular disorders were included in the study. The patients were administered low-molecular-weight heparin subcutaneously. Blood samples were obtained to measure ADMA, SDMA, and arginine levels before treatment and during the treatment (on 10th day). ADMA, SDMA, and l-arginine levels were measured using high performance liquid chromatography method.
  
  
  RESULTS
  The ADMA and SDMA levels were significantly higher in acute DVT patients when compared with the controls (P = 0.001). Post-treatment decrease of ADMA and SDMA levels when compared with the pretreatment levels were found as statistically significant (P = 0.001). Increase in l-arginine levels were not found significant when compared with the control group (P = 0.12) or post-treatment levels (P = 0.16).
  
  
  CONCLUSIONS
  We concluded that ADMA and SDMA levels can be used as parameters in clinical follow-up for determining the efficacy of treatment in acute DVT patients, and further studies are needed to further clarify the subject.
authors.affiliation: Department of Cardiovascular Surgery, Education and Research Hospital, Elazıg, Turkey. Electronic address: ssenol2014@gmail.com.
authors.forename: Sefa
authors.initials: S
authors.lastname: Senol
authors.affiliation: Faculty of Medicine, Department of Cardiovascular Surgery, Bezmialem Vakif University, Istanbul, Turkey.
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Tekumit
authors.affiliation: Faculty of Medicine, Department of Cardiovascular Surgery, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Akar
authors.affiliation: Faculty of Medicine, Department of Cardiovascular Surgery, Gaziosmanpasa University, Tokat, Turkey.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ince
mesh_terms: D000208:Acute Disease; D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000628:therapy
chemical_list: D015415:Biomarkers; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine