title: Balancing cell behavior at boundaries.
abstract: The restriction of cell intermingling across boundaries is essential for the establishment of discrete tissues. Eph receptor signaling prevents intermingling at many boundaries. In this issue, Luu et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201409026) report a parallel pathway, mediated by Wnt signaling, Snail1, and paraxial protocadherin (PAPC). This pathway establishes a distinctive organization of cell adhesion and intercellular gaps at the interface between tissues.
authors.affiliation: Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK dwilkin@nimr.mrc.ac.uk.
authors.forename: David G
authors.initials: DG
authors.lastname: Wilkinson
mesh_terms: D000818:Animals; D015820:Cadherins / Q000502:physiology*; D000091363:Protocadherins; D029867:Xenopus Proteins / Q000502:physiology*
chemical_list: D015820:Cadherins; C117635:Pcdh8 protein, Xenopus; D000091363:Protocadherins; D029867:Xenopus Proteins