title: Ni-catalyzed highly chemo-, regio-, and enantioselective decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids.
abstract: A novel Ni-catalyzed decarboxylative aldol reaction of β,γ-unsaturated α-ketoesters with β-ketoacids is reported. The reaction proceeds smoothly with high chemo-, regio-, and enantioselectivity. This protocol provides a convenient approach to access enantioenriched chiral tertiary alcohols.
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China.
authors.forename: Ai-Jia
authors.initials: AJ
authors.lastname: Wei
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Chemistry, Key Laboratory of Systems Bioengineering (The Ministry of Education), Tianjin University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. of China.
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007651:Keto Acids / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D007651:Keto Acids; D009532:Nickel