title: Association of ABCB1 polymorphisms and ulcerative colitis susceptibility.
abstract: OBJECTIVE
  Multi-drug resistance gene 1 (ABCB1) is closely related to bowel diseases. Therefore, our study was aimed to evaluate the correlation between ABCB1 polymorphisms (C1236T and C3435T) and ulcerative colitis (UC) susceptibility.
  
  
  METHODS
  A total of 61 UC patients and 64 healthy people participated in the study. Genotyping was conducted with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). χ(2) test was used to evaluate the association of ABCB1 gene polymorphisms (C1236T and C3435T) and UC susceptibility.
  
  
  RESULTS
  For ABCB1 C1236T polymorphism, the frequencies of CC genotype and C allele were found higher in the cases than those in the controls (CC: 36.1% vs. 20.3%; C: 58.2% vs. 41.4%), which indicated that the CC genotype and C allele might increase the risk for UC (OR = 3.39, 95% CI = 1.28-8.97; OR = 1.97, 95% CI = 1.19-3.26). However, there were no statistical differences in the genotype or allele distribution of ABCB1 C3435T between the case and control group.
  
  
  CONCLUSIONS
  The CC genotype and C allele of ABCB1 C1236T polymorphisms are significantly associated with UC susceptibility, so we conclude that ABCB1 C1236T polymorphisms might serve as genetic-susceptibility factors for UC. While, no remarkable relationship is observed between ABCB1 C3435T polymorphisms and UC.
authors.affiliation: Department of Gastroenterology, 306 Hospital of PLA Beijing, China.
authors.forename: Yanju
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Gastroenterology, 306 Hospital of PLA Beijing, China.
authors.forename: Changmin
authors.initials: C
authors.lastname: Qu
authors.affiliation: Department of Gastroenterology, 306 Hospital of PLA Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, 306 Hospital of PLA Beijing, China.
authors.forename: Lianyong
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, 306 Hospital of PLA Beijing, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wang
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000328:Adult; D003093:Colitis, Ulcerative / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: ABCB1; polymorphisms; risk; ulcerative colitis