title: Use of polycaprolactone grafts for small-diameter blood vessels.
abstract: Current trends are toward actively developing approaches of tissue engineering, aimed at creating vascular grafts of small diameter. This is due to the existing in cardiovascular surgery demand for prostheses to be used in coronary artery bypass grafting. The present work was undertaken in order to assess possibilities of using smalldiameter vascular grafts made of biodegradable polymer polycaprolactone by means of electrospinning. The authors studied physico-mechanical properties and structure of polycaprolactone grafts, as well as their thromboresistance and patency after implantation into the vascular bed of rats. The obtained results demonstrated optimal physicomechanical properties of the vascular grafts, their biocompatibility, endothelialisation of the internal surface, and infiltration of the graft's wall by cells with the formation of new tissue, accompanied and followed by the development of an extensive intimal layer in the zones of the anastomoses. Hence, the study showed possibilities of using polycaprolactone grafts as vascular prostheses, however requiring their further modification which would promote and contribute to a decrease in hyperplasia of connective tissue in the graft's lumen.
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Sevost'ianova
authors.affiliation: Cleveland VA Medical Center, Department of Surgery, Cleveland, OH, USA.
authors.forename: Ia A
authors.initials: IaA
authors.lastname: Elgudin
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: T V
authors.initials: TV
authors.lastname: Glushkova
authors.affiliation: Case Western Reserve University, Department of Macromolecules Science and Engineering, Cleveland, OH, USA.
authors.forename: G
authors.initials: G
authors.lastname: Wnek
authors.affiliation: Case Western Reserve University, Department of Macromolecules Science and Engineering, Cleveland, OH, USA.
authors.forename: T
authors.initials: T
authors.lastname: Liubysheva
authors.affiliation: Cleveland VA Medical Center, Department of Surgery, Cleveland, OH, USA.
authors.forename: S
authors.initials: S
authors.lastname: Emancipator
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kudriavtseva
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Borisov
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: A S
authors.initials: AS
authors.lastname: Golovkin
authors.affiliation: Federal State Budgetary Facility "Scientific Research Institute for Complex Problems of Cardiovascular Diseases" under the Siberian Branch of the Russian Academy of Medical Sciences, Department of Experimental and Clinical Cardiology, Kemerovo, Russia.
authors.forename: L S
authors.initials: LS
authors.lastname: Barbarash
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D002417:Cattle; D001026:Coronary Artery Bypass / Q000295:instrumentation*; D003324:Coronary Artery Disease / Q000473:pathology / Q000601:surgery*; D023903:Coronary Restenosis / Q000517:prevention & control; D003331:Coronary Vessels / Q000601:surgery* / Q000648:ultrastructure; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D008297:Male; D008854:Microscopy, Electron; D011091:Polyesters; D011474:Prosthesis Design; D051381:Rats; D017208:Rats, Wistar; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D011091:Polyesters; C016240:polycaprolactone