title: Morphometry of the amygdala in schizophrenia and psychotic bipolar disorder.
abstract: Volumetric studies suggest smaller amygdalae in subjects with schizophrenia (SZ) than with bipolar disorder (BP). We use morphometry to identify subregions of amygdala differentially affected in SZ and psychotic BP. Based on template centered population analysis, the shape of the amygdala in psychotic BP differs from SZ (pleft=0.044, pright=0.042). Using a high-field 7 T atlas, the bilateral basolateral, basomedial and centromedial subregions and the right lateral subregion were significantly atrophied in SZ compared to psychotic BP (p<0.02). These results suggest that change in shape of amygdala may represent a morphologic feature distinguishing SZ from psychotic BP.
authors.affiliation: Mood Disorders Center, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. Electronic address: pbelmon2@jhmi.edu.
authors.forename: Pamela B
authors.initials: PB
authors.lastname: Mahon
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Lee
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Huong
authors.initials: H
authors.lastname: Trinh
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Tward
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Michael I
authors.initials: MI
authors.lastname: Miller
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Laurent
authors.initials: L
authors.lastname: Younes
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Barta
authors.affiliation: Center for Imaging Science, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: J Tilak
authors.initials: JT
authors.lastname: Ratnanather
mesh_terms: D000328:Adult; D000368:Aged; D000679:Amygdala / Q000473:pathology*; D001714:Bipolar Disorder / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*
keywords: Amygdala; Morphometry; Psychotic bipolar disorder; Schizophrenia