title: Controlled release of retinyl acetate from β-cyclodextrin functionalized poly(vinyl alcohol) electrospun nanofibers.
abstract: Retinyl acetate (RA) was effectively incorporated into electrospun nanofibers of poly(vinyl alcohol) (PVA) containing β-cyclodextrin (β-CD) in order to form inclusion complexes for encapsulation to prolong shelf life and thermal stability. The physical and thermal properties of encapsulated RA were determined by scanning electron microscopy (SEM), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). The nanofibers of PVA/RA and PVA/RA/β-CD exhibited bead free average fiber diameters of 264 ± 61 and 223 ± 49 nm, respectively. The surface chemistry of the functional nanofibers was investigated by X-ray photoelectron spectroscopy (XPS). Thermogravimetric analysis (TGA) demonstrated different thermal stabilities between the bioactive and the polymer, with and without β-CD. Square-wave voltammogram peak current changes were used to follow the release kinetics of RA from the nanofibers. Results indicate that RA coated inside PVA/β-CD nanofibers was protected against oxidation much better than RA in PVA nanofibers and should extend the shelf life. In addition, RA encapsulated in the PVA/β-CD had better thermal stability than PVA nanofibers.
authors.affiliation: †Faculty of Science and Technology, Free University of Bolzano, Piazza Università 5, 39100 Bolzano, Italy.|‡Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.|∥Industrial Research Institute Swinburne (IRIS), Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: Solomon M
authors.initials: SM
authors.lastname: Lemma
authors.affiliation: †Faculty of Science and Technology, Free University of Bolzano, Piazza Università 5, 39100 Bolzano, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Scampicchio
authors.affiliation: ‡Department of Chemistry and Biotechnology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mahon
authors.affiliation: §Department of Mechanical and Product Design Engineering, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: Igor
authors.initials: I
authors.lastname: Sbarski
authors.affiliation: §Department of Mechanical and Product Design Engineering, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.|∥Industrial Research Institute Swinburne (IRIS), Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Wang
authors.affiliation: †Faculty of Science and Technology, Free University of Bolzano, Piazza Università 5, 39100 Bolzano, Italy.|§Department of Mechanical and Product Design Engineering, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Kingshott
mesh_terms: D002152:Calorimetry, Differential Scanning; D002214:Capsules / Q000138:chemical synthesis; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004224:Diterpenes; D004355:Drug Stability; D055664:Electrochemical Techniques; D006358:Hot Temperature; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000737:chemistry; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004224:Diterpenes; D000084562:Retinyl Esters; D047392:beta-Cyclodextrins; D014801:Vitamin A; C009166:retinol acetate; D011142:Polyvinyl Alcohol; C031215:betadex
keywords: X-ray photoelectron spectroscopy (XPS); cyclodextrin; electrospinning; nanofiber; poly(vinyl alcohol) (PVA); retinyl acetate