title: Sensory gating in adult with attention-deficit/hyperactivity disorder: Event-evoked potential and perceptual experience reports comparisons with schizophrenia.
abstract: BACKGROUND
  In daily life, adults with attention-deficit/hyperactivity disorder (ADHD) report abnormal perceptual experiences that can be related to sensory gating deficit. This study investigated and compared P50 suppression (a neurophysiological measure of sensory gating) and perceptual abnormalities related to sensory gating deficit in ADHD and schizophrenias patients.
  
  
  METHODS
  Three groups were compared: 24 adults with ADHD, 24 patients with schizophrenia and 24 healthy subjects. The Sensory Gating Inventory (SGI), a validated self-report questionnaire, was used to measure perceptual abnormalities related to sensory gating deficit. P50 suppression was measured by P50 amplitude changes in a dual-click conditioning-testing auditory event-related potential procedure.
  
  
  RESULTS
  Adults with ADHD had significantly higher scores on the SGI and significantly lower P50 suppression than healthy subjects. These deficits were similar to those found in patients with schizophrenia. A correlation was found between both the SGI and P50 suppression data in adults with ADHD and patients with schizophrenia.
  
  
  CONCLUSIONS
  The findings confirm previous results found in patients with schizophrenia. Moreover, adults with ADHD, similar to patients with schizophrenia, had abnormal P50 suppression and reported being flooded with sensory stimuli. Abnormal neurophysiologic responses to repetitive stimuli gave rise to clinically abnormal perceptions.
authors.affiliation: Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Services d'explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France. Electronic address: jarthur.micoulaud@gmail.com.
authors.forename: Jean-Arthur
authors.initials: JA
authors.lastname: Micoulaud-Franchi
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Vaillant
authors.affiliation: Service de Neurologie, Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac Montpellier, Montpellier, France; Inserm U1061, Montpellier F-34000 France.
authors.forename: Régis
authors.initials: R
authors.lastname: Lopez
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Pauline
authors.initials: P
authors.lastname: Peri
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Baillif
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France.
authors.forename: Laura
authors.initials: L
authors.lastname: Brandejsky
authors.affiliation: Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.
authors.forename: Marie Laure
authors.initials: ML
authors.lastname: Steffen
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Université de la Méditerranée-EA 3279-Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Université de la Méditerranée-EA 3279-Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Raphaëlle
authors.initials: R
authors.lastname: Richieri
authors.affiliation: Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Cermolacce
authors.affiliation: USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France; Pôle Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Bordeaux, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bioulac
authors.affiliation: Laboratoire de Mécanique et d'Acoustique, LMA, CNRS, UPR 7051, Aix-Marseille Univ, Centrale Marseille, F-13402 Marseille Cedex 20, France.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Aramaki
authors.affiliation: Services d'explorations fonctionnelles du système nerveux, Clinique du sommeil, CHU de Bordeaux, Place Amélie Raba-Leon, 33076 Bordeaux, France; USR CNRS 3413 SANPSY, CHU Pellegrin, Université de Bordeaux, Talence, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Philip
authors.affiliation: Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Université de la Méditerranée-EA 3279-Faculté de Médecine, 27 bd Jean Moulin, 13385 Marseille Cedex 05, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Lancon
authors.affiliation: Unité de Neurophysiologie et Psychophysiologie, Pôle de Psychiatrie Universitaire, CHU Sainte-Marguerite, 270 Bd Sainte-Marguerite, 13009 Marseille, France; Pôle de Psychiatrie "Solaris", Centre Hospitalier Universitaire de Sainte-Marguerite, 270 Bd de Sainte-Marguerite, 13009 Marseille, France; Laboratoire de Neurosciences Cognitives (LNC), UMR CNRS 7291, 31 Aix-Marseille Université, Site St Charles, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Vion-Dury
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001303:Auditory Cortex / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000503:physiopathology*; D057566:Self Report; D055139:Sensory Gating / Q000502:physiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: ADHD; Adult; P50 suppression; Perceptual anomalies; Self-report; Sensory gating