title: Comparison of Strut Coverage at 6 Months by Optical Coherence Tomography With Everolimus-Eluting Stenting of Bare-Metal Stent Restenosis Versus Stenosis of Nonstented Atherosclerotic Narrowing (from the DESERT Study).
abstract: Incomplete struts coverage is a predictor of late stent thrombosis after implantation of the drug-eluting stents (DES) in atherosclerotic lesions. The process of struts coverage in DES implanted for bare-metal stent (BMS) restenosis has never been described. Thirty-two patients with stable coronary artery disease were consecutively selected, 11 with BMS restenosis (group A) and 21 with de novo atherosclerotic lesions (group B). All patients underwent everolimus-eluting stent implantation; coronary angiography and optical coherence tomography were performed at 6 months follow-up. Percentage difference in struts coverage between the 2 groups was the primary end point. A total of 85,773 struts (17,891 in group A and 67,882 in group B) were analyzed: compared with group B, the percentage of uncovered stent struts was significantly lower in group A (2.6% vs 4.8%; p <0.0001). In group A, DES struts protruding out of BMS were more uncovered (5.0% vs 1.9%; p <0.0001) and malapposed (4.1% vs 2.1%; p <0.0001) compared with overlapping struts. In conclusion, when DES are implanted to treat BMS restenosis, struts coverage at 6 months follow-up is more complete compared with DES implanted in atherosclerotic lesions.
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy. Electronic address: andre.picchi@gmail.com.
authors.forename: Andrea
authors.initials: A
authors.lastname: Picchi
authors.affiliation: Cardiovascular Department, AO Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumeci
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabria
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cresti
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rescigno
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Aruffo
authors.affiliation: Cardiology, San Giovanni- Hospital, CLI foundation, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Prati
authors.affiliation: Cardiology Department, Misericordia Hospital, Grosseto, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Limbruno
mesh_terms: D000970:Antineoplastic Agents; D050197:Atherosclerosis / Q000175:diagnosis* / Q000601:surgery; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000175:diagnosis / Q000601:surgery; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000601:surgery; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery; D054855:Drug-Eluting Stents; D004562:Electrocardiography; D000068338:Everolimus; D005500:Follow-Up Studies; D007166:Immunosuppressive Agents / Q000494:pharmacology; D011474:Prosthesis Design; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016037:Single-Blind Method; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus