title: Expression of vascular endothelial growth factor (VEGF-A) in rat mandibular salivary gland during paraneoplastic process and treatment with cyclophosphamide and melatonin.
abstract: Expression of VEGF-A in Walker 256 carcinosarcoma and mandibular salivary gland of rats during paraneoplastic process and various regimens of chemotherapy with melatonin and cyclophosphamide were studied by immunohistochemical methods. VEGF-A expression increased in the tumor node and salivary gland after monotherapy with melatonin and cyclophosphamide during progression of tumor growth and paraneoplastic syndrome. A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and, especially, after combined treatment, which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action. Overexpression of VEGF-A in the mandibular salivary gland can have diagnostic and predictive value in early diagnostics of neoplasms.
authors.affiliation: Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia, pathol@inbox.ru.
authors.forename: E V
authors.initials: EV
authors.lastname: Ovsyanko
authors.forename: A O
authors.initials: AO
authors.lastname: Kulishenko
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: A S
authors.initials: AS
authors.lastname: Vinogradov
authors.forename: I P
authors.initials: IP
authors.lastname: Zhurakovskii
authors.forename: M G
authors.initials: MG
authors.lastname: Pustovetova
authors.forename: Ya U
authors.initials: YU
authors.lastname: Ovsyanko
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000378:metabolism*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D007150:Immunohistochemistry; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D042461:Vascular Endothelial Growth Factor A; D003520:Cyclophosphamide; D008550:Melatonin