title: Chronic urticaria due to autoreactivity to progesterone.
abstract: A 23-year-old, regularly menstruating woman presented with recurrent urticarial eruptions, which occurred premenstrually. A skin prick test was positive for progesterone, but the urticaria was unresponsive to standard treatments. The patient was treated with goserelin (Zoladex), which suppressed her menstrual cycle, leading to the resolution of her symptoms. Subsequent flares were controlled by further goserelin injections, and the urticaria is currently in remission. However, the risks of inducing menopause artificially are significant, and alternative long-term solutions may need to be considered in the event of a relapse.
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Wingate-Saul
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Rymer
authors.affiliation: Guy's and St Thomas' NHS Foundation Trust, London, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology*; D002908:Chronic Disease; D005260:Female; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D011374:Progesterone / Q000276:immunology*; D016896:Treatment Outcome; D014581:Urticaria / Q000209:etiology*; D055815:Young Adult
chemical_list: D017273:Goserelin; D011374:Progesterone