title: Biocompatible hydrogel nanocomposite with covalently embedded silver nanoparticles.
abstract: Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silver nanoparticles (Ag NPs) as cocross-linkers for the preparation of a bionanocomposite gelatin based hydrogel. Diels-Alder cycloaddition of benzotriazole maleimide (BTM) functionalized Ag NPs and furan containing gelatin in combination with additional amide coupling resulted in stable and biocompatible hybrid nanocomposite. The storage moduli values for the hydrogel are nearly three times higher than that of control hydrogel without NPs indicating a stabilizing role of the covalently bound NPs. Finally, the swelling and drug release properties of the materials as well as the biocompatibility and toxicity tests indicate the biomedical potential of this type of material.
authors.affiliation: †Materials + Technologies Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 San Sebastián, Spain.
authors.forename: Clara
authors.initials: C
authors.lastname: García-Astrain
authors.affiliation: ‡DGF-Centre for Functional Nanostructures, Karlsruhe Institute of Technology (KIT), Wofgang Gaede Str. 1a, 76131 Karlsruhe, Germany.
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: §Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940 Leioa, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Burón
authors.affiliation: §Faculty of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, 48940 Leioa, Spain.
authors.forename: Teodoro
authors.initials: T
authors.lastname: Palomares
authors.affiliation: †Materials + Technologies Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 San Sebastián, Spain.
authors.forename: Arantxa
authors.initials: A
authors.lastname: Eceiza
authors.affiliation: ‡DGF-Centre for Functional Nanostructures, Karlsruhe Institute of Technology (KIT), Wofgang Gaede Str. 1a, 76131 Karlsruhe, Germany.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Fruk
authors.affiliation: †Materials + Technologies Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 San Sebastián, Spain.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Corcuera
authors.affiliation: †Materials + Technologies Group, Department of Chemical and Environmental Engineering, Polytechnic School, University of the Basque Country, Plaza Europa 1, 20018 San Sebastián, Spain.
authors.forename: Nagore
authors.initials: N
authors.lastname: Gabilondo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002460:Cell Line; D005347:Fibroblasts / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D008301:Maleimides / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D012834:Silver / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels; D008301:Maleimides; D012834:Silver; D005780:Gelatin