title: Enantioselective intramolecular hydroacylation of unactivated alkenes: an NHC-catalyzed robust and versatile formation of cyclic chiral ketones.
abstract: A highly enantioselective intramolecular N-heterocyclic carbene (NHC)-catalyzed hydroacylation reaction gives access to a range of cyclic ketones from unactivated olefin-substituted aldehydes (up to 99 % ee). Remarkably, aliphatic aldehydes were also transformed efficiently in an NHC-catalyzed hydroacylation reaction for the first time.
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
authors.forename: Daniel
authors.initials: D
authors.lastname: Janssen-Müller
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
authors.forename: Michael
authors.initials: M
authors.lastname: Schedler
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
authors.forename: Mirco
authors.initials: M
authors.lastname: Fleige
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/
authors.forename: Constantin G
authors.initials: CG
authors.lastname: Daniliuc
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/. glorius@uni-muenster.de.
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
keywords: N-heterocyclic carbenes; enantioselective catalysis; hydroacylation; organocatalysis