title: N-Aryl-5-aminopyrazole: a versatile architecture in medicinal chemistry.
abstract: N-Aryl-5-aminopyrazole represents a key structural motif in a plethora of biologically active molecules endowed with a wide spectrum of pharmacological properties. Accordingly, this scaffold can be certainly included in the category of a privileged structure. As an example, N-aryl-5- aminopyrazole along with its 5-ureido derivatives are recurrent scaffolds in the field of inhibition of the different members of mitogen-activated protein kinases (MAPKs). Over the past recent years a large number of papers highlighting the design, synthesis and biological evaluation of different classes of N-aryl-5-aminopyrazole-containing compounds have been reported in the literature, but a review on this topic is still missing. With the aim to fill this gap, the present review article focuses on the recent developments (1995-mid2014) on the application of the N-aryl-5-aminopyrazole-based compounds in different therapeutic fields, with a particular attention to the design and structure-activity relationships (SAR) aspects of each class of compounds.
authors.forename: Maura
authors.initials: M
authors.lastname: Marinozzi
authors.forename: Gloria
authors.initials: G
authors.lastname: Marcelli
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Perugia, Via del Liceo, 1-06123 Perugia, Italy. maura.marinozzi@unipg.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Carotti
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006801:Humans; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011720:Pyrazoles