title: Contrast-enhanced ultrasonography in differential diagnosis of benign and malignant ovarian tumors.
abstract: OBJECTIVE
  To evaluate the accuracy of contrast-enhanced ultrasonography (CEUS) in differential diagnosis of benign and malignant ovarian tumors.
  
  
  METHODS
  The scientific literature databases PubMed, Cochrane Library and CNKI were comprehensively searched for studies relevant to the use of CEUS technique for differential diagnosis of benign and malignant ovarian cancer. Pooled summary statistics for specificity (Spe), sensitivity (Sen), positive and negative likelihood ratios (LR+/LR-), and diagnostic odds ratio (DOR) and their 95%CIs were calculated. Software for statistical analysis included STATA version 12.0 (Stata Corp, College Station, TX, USA) and Meta-Disc version 1.4 (Universidad Complutense, Madrid, Spain).
  
  
  RESULTS
  Following a stringent selection process, seven high quality clinical trials were found suitable for inclusion in the present meta-analysis. The 7 studies contained a combined total of 375 ovarian cancer patients (198 malignant and 177 benign). Statistical analysis revealed that CEUS was associated with the following performance measures in differential diagnosis of ovarian tumors: pooled Sen was 0.96 (95%CI = 0.92∼0.98); the summary Spe was 0.91 (95%CI = 0.86∼0.94); the pooled LR+ was 10.63 (95%CI = 6.59∼17.17); the pooled LR- was 0.04 (95%CI = 0.02∼0.09); and the pooled DOR was 241.04 (95% CI = 92.61∼627.37). The area under the SROC curve was 0.98 (95% CI = 0.20∼1.00). Lastly, publication bias was not detected (t = -0.52, P = 0.626) in the meta-analysis.
  
  
  CONCLUSIONS
  Our results revealed the high clinical value of CEUS in differential diagnosis of benign and malignant ovarian tumors. Further, CEUS may also prove to be useful in differential diagnosis at early stages of this disease.
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Qiao
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Yu
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Song
authors.affiliation: The Second Department of Oncology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, P.R. China.
authors.forename: Man
authors.initials: M
authors.lastname: Li
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000175:diagnosis*; D014463:Ultrasonography / Q000379:methods*
chemical_list: D003287:Contrast Media