title: Vaccination coverage of children with inflammatory bowel disease after an awareness campaign on the risk of infection.
abstract: BACKGROUND
  Children with inflammatory bowel disease are at risk of vaccine-preventable diseases mostly due to immunosuppressive drugs.
  
  
  OBJECTIVE
  To evaluate coverage after an awareness campaign informing patients, their parents and general practitioner about the vaccination schedule.
  
  
  METHODS
  Vaccination coverage was firstly evaluated and followed by an awareness campaign on the risk of infection via postal mail. The trial is a case-control study on the same patients before and after the awareness campaign. Overall, 92 children were included. A questionnaire was then completed during a routine appointment to collect data including age at diagnosis, age at data collection, treatment history, and vaccination status.
  
  
  RESULTS
  Vaccination rates significantly increased for vaccines against diphtheria-tetanus-poliomyelitis (92% vs. 100%), Haemophilus influenzae (88% vs. 98%), hepatitis B (52% vs. 71%), pneumococcus (36% vs. 57%), and meningococcus C (17% vs. 41%) (p<0.05). Children who were older at diagnosis were 1.26 times more likely to be up-to-date with a minimum vaccination schedule (diphtheria-tetanus-poliomyelitis, pertussis, H. influenzae, measles-mumps-rubella, tuberculosis) (p=0.002).
  
  
  CONCLUSIONS
  Informing inflammatory bowel disease patients, their parents and general practitioner about the vaccination schedule via postal mail is easy, inexpensive, reproducible, and increases vaccination coverage. This method reinforces information on the risk of infection during routine visits.
authors.affiliation: CHU Rennes, Paediatric Centre, Hôpital Sud, Rennes Cedex, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Fleurier
authors.affiliation: CH Le Mans, Paediatric Department, Le Mans, France.
authors.forename: Cecile
authors.initials: C
authors.lastname: Pelatan
authors.affiliation: CHU Tours, Paediatric Department, CH Clocheville, Tours Cedex, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Willot
authors.affiliation: CHU Angers, Paediatric Department, Angers Cedex 01, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Ginies
authors.affiliation: CH Saint Brieuc, Hôpital Y. Le Foll, Paediatric Department, Saint Brieuc, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Breton
authors.affiliation: CHU Rennes, Paediatric Centre, Hôpital Sud, Rennes Cedex, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Bridoux
authors.affiliation: CHU Brest, CH Morvan, Paediatric Department, Brest, France.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Segura
authors.affiliation: CHU Angers, Paediatric Department, Angers Cedex 01, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Chaillou
authors.affiliation: CH Saint Nazaire, Paediatric Department, Boulevard de l'hôpital, Saint Nazaire, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Jobert
authors.affiliation: CHU Angers, Paediatric Department, Angers Cedex 01, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Darviot
authors.affiliation: CH Auray-Vannes, Hôpital Bretagne Atlantique, Paediatric Department, Boulevard du Général Guillaudot, Vannes Cedex, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Cagnard
authors.affiliation: CHU Brest, CH Morvan, Paediatric Department, Brest, France.
authors.forename: Nadege
authors.initials: N
authors.lastname: Delaperriere
authors.affiliation: CH Cholet, Paediatric Department, Cholet Cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Grimal
authors.affiliation: CHU Rennes, Paediatric Centre, Hôpital Sud, Rennes Cedex, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Carre
authors.affiliation: CH Saint Nazaire, Paediatric Department, Boulevard de l'hôpital, Saint Nazaire, France.
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Wagner
authors.affiliation: CHU Rennes, Public Health Department, Rennes, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Sylvestre
authors.affiliation: CHU Rennes, Paediatric Centre, Hôpital Sud, Rennes Cedex, France. Electronic address: Alain.dabadie@chu-rennes.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Dabadie
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D007115:Immunization Schedule; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000517:prevention & control*; D017063:Outcome Assessment, Health Care; D010353:Patient Education as Topic / Q000379:methods*; D011446:Prospective Studies; D014611:Vaccination / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Awareness-raising; Children; IBD; Opportunistic infections; Vaccination