title: Parkinson's disease and enhanced inflammatory response.
abstract: Parkinson's disease (PD) is the first and second most prevalent motor and neurodegenerative disease, respectively. The clinical symptoms of PD result from a loss of midbrain dopaminergic (DA) neurons. However, the molecular cause of DA neuron loss remains elusive. Mounting evidence implicates enhanced inflammatory response in the development and progression of PD pathology. This review examines current research connecting PD and inflammatory response.
authors.affiliation: Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA.
authors.forename: Iva
authors.initials: I
authors.lastname: Stojkovska
authors.affiliation: Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA.
authors.forename: Brandon M
authors.initials: BM
authors.lastname: Wagner
authors.affiliation: Department of Biological Sciences, Boise State University, Boise, ID 83725-1515, USA bradmorrison@boisestate.edu.
authors.forename: Brad E
authors.initials: BE
authors.lastname: Morrison
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000737:chemistry; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D059290:Dopaminergic Neurons / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008070:Lipopolysaccharides / Q000737:chemistry; D009474:Neurons / Q000378:metabolism; D018384:Oxidative Stress; D016627:Oxidopamine / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010269:Paraquat / Q000737:chemistry; D010300:Parkinson Disease / Q000276:immunology* / Q000503:physiopathology; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D008070:Lipopolysaccharides; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D010269:Paraquat; D010100:Oxygen; D004298:Dopamine
keywords: Parkinson’s disease; disease models; inflammation; neuroinflammation