title: Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury: Effect of the competitive antagonist 1-aminoindan-1, 5-dicarboxylic acid.
abstract: The diffuse brain injury model was conducted in Sprague-Dawley rats, according to Marmarou's free-fall attack. The water content in brain tissue, expression of metabotropic glutamate receptor 1α mRNA and protein were significantly increased after injury, reached a peak at 24 hours, and then gradually decreased. After treatment with the competitive antagonist of metabotropic glutamate receptor 1α, (RS)-1-aminoindan-1, 5-dicarboxylic acid, the water content of brain tissues decreased between 12-72 hours after injury, and neurological behaviors improved at 2 weeks. These experimental findings suggest that the 1-aminoindan-1, 5-dicarboxylic acid may result in marked neuroprotection against diffuse brain injury.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Mantao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China ; Institute of Brain Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Xiujue
authors.initials: X
authors.lastname: Zheng
keywords: 1-aminoindan-1, 5-dicarboxylic acid; animal model; diffuse brain injury; in vivo; metabotropic glutamate receptor 1 alpha