title: [Hyperviscosity syndrome].
abstract: Hyperviscosity syndrome is a life-threatening complication. Clinical manifestations include neurological impairment, visual disturbance and bleeding. Measurement of plasma or serum viscosity by a viscometer assesses the diagnosis. Funduscopic examination is a key exam because abnormalities are well-correlated with abnormal plasma viscosity. Etiologies are various but symptomatic hyperviscosity is more common in Waldenström's macroglobulinemia and multiple myeloma. Prompt treatment is needed: treatment of the underlying disease should be considered, but generally not sufficient. Symptomatic measures aim to not exacerbate blood viscosity while urgent plasmapheresis effectively reduces the paraprotein concentration and relieves symptoms.
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: dumas.guillaume1@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Dumas
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: sybille07@gmail.com.
authors.forename: S
authors.initials: S
authors.lastname: Merceron
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: larazafrani@hotmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Zafrani
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: emmanuel.canet@sls.aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Canet
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: virginie.lemiale@sls.aphp.fr.
authors.forename: V
authors.initials: V
authors.lastname: Lemiale
authors.affiliation: Service de réanimation médicale, CHU d'Angers, 4, rue Larrey, 49100 Angers, France. Electronic address: ackouatchet@chu-angers.fr.
authors.forename: A
authors.initials: A
authors.lastname: Kouatchet
authors.affiliation: Service de réanimation médicale, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: elie.azoulay@sls.aphp.fr.
authors.forename: E
authors.initials: E
authors.lastname: Azoulay
mesh_terms: D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D001780:Blood Coagulation Tests; D001809:Blood Viscosity; D005451:Fluorescein Angiography; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009887:Ophthalmoscopy; D013577:Syndrome; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis / Q000628:therapy
keywords: Gammapathie monoclonale; Hyperviscosity syndrome; Paraprotein; Plasmapheresis; Syndrome d’hyperviscosité; Échange plasmatique