title: Scleromyxedema with histology resembling granuloma annulare.
abstract: Scleromyxedema is a generalized and progressive fibromucinous disorder associated with substantial cutaneous and systemic morbidity. The diagnosis is often challenging, as is management. We present here a patient with scleromyxedema with atypical, granuloma annulare-like histology, which contributed to delayed diagnosis and management, including a delayed workup for multiple myeloma. Ultimately, the patient did well with appropriate therapy, but his presentation illustrates the importance of more widespread familiarity among dermatologists and dermatopathologists with this variant of scleromyxedema.
authors.forename: Samyukta
authors.initials: S
authors.lastname: Mullangi
authors.forename: Scott R
authors.initials: SR
authors.lastname: Granter
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Laubach
authors.affiliation: Brigham and Women's Hospital.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Lipworth
mesh_terms: D003937:Diagnosis, Differential; D016460:Granuloma Annulare / Q000175:diagnosis*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D053718:Scleromyxedema / Q000150:complications / Q000473:pathology* / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors