title: Association of vitamin D3 with alveolar bone regeneration in dogs.
abstract: Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D3 and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption (VRR), bone density (density), new bone formation (NBF) and implant stability quotient (ISQ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF/Density/VRR and the Alloplast subgroup on items NBF/Density/ISQ/VRR. Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF/Density/ISQ (P < 0.001) and a lower VRR value (P = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF (P = 0.349), density (P = 0.796), ISQ (P = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non-Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF/Density/ISQ (P = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D3 treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D3 treatment displayed a superior stimulating effect than local vitamin D3 application did.
authors.affiliation: Department of Periodontics, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan.|School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Hsiang-Hsi
authors.initials: HH
authors.lastname: Hong
authors.affiliation: Department of Nephrology and Division of Clinical Toxicology, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan.
authors.forename: Tzung-Hai
authors.initials: TH
authors.lastname: Yen
authors.affiliation: Department of Integrative Biology, University of California, Berkeley, CA, USA.
authors.forename: Adrienne
authors.initials: A
authors.lastname: Hong
authors.affiliation: Department of Periodontics, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan.|School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ting-An
authors.initials: TA
authors.lastname: Chou
mesh_terms: D000539:Alveolar Process / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002762:Cholecalciferol / Q000494:pharmacology*; D004285:Dogs; D010012:Osteogenesis / Q000187:drug effects; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
chemical_list: D050071:Bone Density Conservation Agents; D002762:Cholecalciferol; D002117:Calcitriol; D002118:Calcium
keywords: alloplast; bone regeneration; calcitriol; cholecalciferol; ridge preservation; vitamin D3