title: [The relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia].
abstract: The study was designed to analyse the relationship between EGFR mutation and clinico-pathological features of lung adenocarcinoma in residents of southern Russia taking account oftheir age and sex, localization of the primary tumour, its cell differentiation, regional metastases, stage of disease and smoking status of the patients with mutant and wild-type EGFR genes. The frequency analysis included 29 somatic mutations in EGFR exones 18-21. The study revealed statistically significant associations of EGFR gene mutations with gender, smoking and stage of disease.
authors.forename: D I
authors.initials: DI
authors.lastname: Vodolazhskiĭ
authors.forename: O I
authors.initials: OI
authors.lastname: Kit
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Maksimov
authors.forename: A V
authors.initials: AV
authors.lastname: Antonets
authors.forename: K V
authors.initials: KV
authors.lastname: Dvadnenko
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Vladimirova
authors.forename: I A
authors.initials: IA
authors.lastname: Leĭman
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Lazutin
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013223:Statistics as Topic
chemical_list: D066246:ErbB Receptors