title: Anti-Allergic Effect of Ulmus davidiana Cortex on Contact Dermatitis Induced by Dinitrofluoro- Benzene in Mice.
abstract: OBJECTIVE
  The root bark of Ulmus davidiana var. Japonica (Ulmi Radicis cortex, URC) is a medicinal herb used for promoting diuresis and treating dampness. In Korea, URC has long been used as an efficacious therapy for inflammation, burns, frostbite and skin diseases such as eczema and psoriasis.
  
  
  METHODS
  In the present study, we used 1-fluoro-2,4- dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mouse model to investigate the antiallergic and the anti-inflammatory effects of URC on skin lesion, histopathological changes and specific antibody production.
  
  
  RESULTS
  URC treatment, 10 mg/mL, effectively inhibited skin lesions induced by repeated paintings with DNFB. In the histopathological observation, topical application of URC inhibited spongiosis. In addition, URC lowered the production levels of total immunoglobulin and IgG2a in serum.
  
  
  CONCLUSIONS
  These data indicate that URC has an anti-inflammatory effect that produces an improvement of skin lesions in CD mice.
authors.affiliation: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Korea.
authors.forename: Jeonghyeon
authors.initials: J
authors.lastname: Lyu
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Korea.
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Korea.
authors.forename: Hyungwoo
authors.initials: H
authors.lastname: Kim
keywords: Ulmus davidiana; allergy; dermatitis; inflammation; skin