title: The n-Butanol Fraction and Rutin from Tartary Buckwheat Improve Cognition and Memory in an In Vivo Model of Amyloid-β-Induced Alzheimer's Disease.
abstract: This study examined the beneficial effects of the n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning and memory deficits in a mouse model of amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning and memory were assessed using the T-maze, object recognition, and Morris water maze tests. Animals administered Aβ showed impaired cognition and memory, which were alleviated by oral administration of an n-butanol fraction and rutin extracted from TB. Similarly, Aβ-induced increases in nitric oxide formation and lipid peroxidation in the brain, liver, and kidneys were attenuated by treatment with n-butanol fraction and rutin from TB in addition to antioxidant effects observed in control (nonAβ-treated) animals. The results of the present study suggest that the n-butanol fraction and rutin extracted from TB are protective against and have possible therapeutic applications for the treatment of AD.
authors.affiliation: 1Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Choi
authors.affiliation: 2Department of Integrative Plant Science, Chung-Ang University, Anseong, Korea.|3Department of Functional Crops, National Institute of Crop Science, Rural Development Administration, Miryang, Korea.
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: 2Department of Integrative Plant Science, Chung-Ang University, Anseong, Korea.
authors.forename: Dong Gu
authors.initials: DG
authors.lastname: Lee
authors.affiliation: 2Department of Integrative Plant Science, Chung-Ang University, Anseong, Korea.
authors.forename: Sunghun
authors.initials: S
authors.lastname: Cho
authors.affiliation: 3Department of Functional Crops, National Institute of Crop Science, Rural Development Administration, Miryang, Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Yoon
authors.affiliation: 1Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University, Busan, Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Cho
authors.affiliation: 2Department of Integrative Plant Science, Chung-Ang University, Anseong, Korea.
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D019612:Fagopyrum / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000378:metabolism; D008813:Mice, Inbred ICR; D009569:Nitric Oxide / Q000096:biosynthesis; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D012431:Rutin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D010936:Plant Extracts; D009569:Nitric Oxide; D012431:Rutin
keywords: Alzheimer's disease; amyloid β; memory; oxidative stress; rutin; tartary buckwheat