title: The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis.
abstract: Eiger, the sole Drosophila TNF-alpha homolog, causes ectopic apoptosis through JNK pathway activation. Yet, its role in developmental apoptosis remains unclear. eiger mutant flies are viable and fertile but display compromised elimination of oncogenic cells and extracellular bacteria. Here we show that Eiger, specifically expressed in embryonic neurons and glia, is not involved in developmental neuronal apoptosis or in apoptotic cell clearance. Instead, we provide evidence that Eiger is required for damage-induced apoptosis in the embryonic CNS through regulation of the pro-apoptotic gene hid independently of the JNK pathway. Our study thus reveals a new requirement for Eiger in eliminating damaged cells during development.
authors.affiliation: Department of Genetics and Developmental Biology, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 31096, Israel.
authors.forename: Jeny
authors.initials: J
authors.lastname: Shklover
authors.affiliation: Department of Genetics and Developmental Biology, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 31096, Israel.
authors.forename: Flonia
authors.initials: F
authors.lastname: Levy-Adam
authors.affiliation: Department of Genetics and Developmental Biology, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 31096, Israel. Electronic address: kurante@tx.technion.ac.il.
authors.forename: Estee
authors.initials: E
authors.lastname: Kurant
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D001921:Brain / Q000166:cytology / Q000196:embryology; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism / Q000528:radiation effects; D047108:Embryonic Development / Q000528:radiation effects; D018507:Gene Expression Regulation, Developmental / Q000528:radiation effects; D008565:Membrane Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects; D009474:Neurons / Q000166:cytology* / Q000528:radiation effects; D009479:Neuropeptides / Q000378:metabolism; D014965:X-Rays / Q000009:adverse effects
chemical_list: D029721:Drosophila Proteins; C108880:HID protein, Drosophila; D008565:Membrane Proteins; D009479:Neuropeptides; C464573:egr protein, Drosophila
keywords: Apoptosis; CNS; Drosophila; Eiger; Embryo; hid