title: Molecular characterization of group A rotavirus strains detected in children with diarrhea admitted to Nigerian hospitals in 2013.
abstract: Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in children worldwide and cause up to 455,000 deaths annually, mostly in developing countries. During 2013, 66 RVAs from children with AGE admitted to four Nigerian hospitals were investigated. The G3P[6], G1P[8] and G2P[4] genotypes predominated. The VP7 and/or VP4 genes of 18 G3P[6]/[8]/[4], six G2P[4], three G12P[8]/[4], and two G1P[8] RVA strains were sequenced. The G3P[6] strains belonged to lineage G3-III and were different from G3 strains widespread in Asia. Phylogenetic analysis revealed substantial sequence conservation, suggesting continuing evolution and genomic reassortment but no zoonotic RVA transmission from animals.
authors.affiliation: Istituto Superiore di Sanità, V.le Regina Elena, 299, 00161, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ianiro
authors.forename: Roberto
authors.initials: R
authors.lastname: Delogu
authors.forename: Marycelin
authors.initials: M
authors.lastname: Baba
authors.forename: Bamidele S
authors.initials: BS
authors.lastname: Oderinde
authors.forename: Joshua
authors.initials: J
authors.lastname: Dawurung
authors.forename: Franco Maria
authors.initials: FM
authors.lastname: Ruggeri
authors.forename: Lucia
authors.initials: L
authors.lastname: Fiore
mesh_terms: D000956:Antigens, Viral / Q000235:genetics; D001483:Base Sequence; D036022:Capsid Proteins / Q000235:genetics; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D009549:Nigeria / Q000453:epidemiology; D010802:Phylogeny; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus