title: Levocarnitine normalizes elevated blood level of soluble Fas mRNA in patients with acute myocardial infarction.
abstract: Fas-induced apoptosis plays an important role in the mechanisms of tissue injury in myocardial infarction. The level of membrane Fas mRNA was elevated during the postinfarction period in the blood of patients and did not change in response to levocarnitine. The mRNA level of soluble Fas, inhibiting Fas-dependent apoptosis, remained normal during the first 7 days, but increased 14 days after myocardial infarction, which corresponded to previously detected increase of serum level of soluble Fas molecules. Addition of levocarnitine, inhibiting Fas-dependent apoptosis, to therapy caused no changes in the level of soluble Fas mRNA, presumably because of similar effects of soluble Fas and levocarnitine on the apoptotic processes in myocardial infarction.
authors.affiliation: N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia.
authors.forename: D V
authors.initials: DV
authors.lastname: Novikov
authors.forename: S S
authors.initials: SS
authors.lastname: Belousov
authors.forename: A V
authors.initials: AV
authors.lastname: Karaulov
authors.forename: N V
authors.initials: NV
authors.lastname: Eroshevskaya
authors.forename: S V
authors.initials: SV
authors.lastname: Shumilova
authors.forename: E S
authors.initials: ES
authors.lastname: Kasatova
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Kazatskaya
authors.forename: V V
authors.initials: VV
authors.lastname: Novikov
mesh_terms: D002331:Carnitine / Q000627:therapeutic use*; D053222:Fas Ligand Protein / Q000378:metabolism; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy*; D012333:RNA, Messenger / Q000097:blood*; D060888:Real-Time Polymerase Chain Reaction; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
chemical_list: D053222:Fas Ligand Protein; D012333:RNA, Messenger; D019014:fas Receptor; D002331:Carnitine