title: The role of autophagy in Parkinson's disease.
abstract: Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
authors.affiliation: Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Yaru
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Xiaoheng
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Xu
keywords: Parkinson's disease; autophagy-lysosome pathway; pathogenesis; review