title: Non-canonical manifestations of familial Mediterranean fever: a changing paradigm.
abstract: Paroxysmal crises of fever and systemic inflammation herald familial Mediterranean fever (FMF), considered as the archetype of all inherited systemic autoinflammatory diseases. Inflammatory bouts are characterized by short-term and self-limited abdominal, thoracic, and/or articular symptoms which subside spontaneously. Erysipelas-like findings, orchitis, and different patterns of myalgia may appear in a minority of patients. In recent years, many non-classical manifestations have been reported in the clinical context of FMF, such as vasculitides and thrombotic manifestations, neurologic and sensory organ abnormalities, gastrointestinal diseases, and even macrophage activation syndrome. As FMF left unrecognized and untreated is ominously complicated by the occurrence of AA-amyloidosis, it is highly desirable that diagnosis of this autoinflammatory disorder with its multiple clinical faces can be contemplated at whatever age and brought forward.
authors.affiliation: Institute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lopalco
authors.forename: Giusyda
authors.initials: G
authors.lastname: Tarantino
authors.forename: Adele
authors.initials: A
authors.lastname: Compagnone
authors.forename: Michele
authors.initials: M
authors.lastname: Fastiggi
authors.forename: Luca
authors.initials: L
authors.lastname: Cantarini
mesh_terms: D000686:Amyloidosis / Q000150:complications*; D003078:Colchicine / Q000627:therapeutic use*; D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D014657:Vasculitis / Q000150:complications*
chemical_list: D003078:Colchicine