title: The network of antigen-antibody reactions in adult women with breast cancer or benign breast pathology or without breast pathology.
abstract: The Immunoglobulin G (IgG) antibody response to different protein antigens of the mammary ductal carcinoma by adult women affected by Breast Cancer (BC) distinguishes at least 103 proteins that differ in their molecular weights (MW). The IgG producing cell clones (nodes) coexist with each other in each individual organism and share energy resources among themselves, as well as factors that control the level of expression and Specificity of their IgG antibodies. So, it can be proposed that among them there is a Network of interconnections (links) unveiled by the antigens, which specifically react with the IgG antibodies produced by the clones. This Network possibly regulates IgG antibodies' activity and effectiveness. We describe the Network of nodes and links that exists between the different antigens and their respective IgG producing cell clones against the extracted protein antigens from the cells of the T47D Cell-Line, in 50 women with BC, 50 women with Benign Breast Pathology (BBP) and 50 women without breast pathology (H). We have found that women with BBP have the highest number of Links, followed by the H group and, lastly, the women with BC, a finding which suggests that cancer interferes with the Connectivity between the IgG producing cell clones and blocks the expression of 322 links in women with BBP and 32 links in women with H. It is also plausible that the largest number of links in the women with BBP indicates the Network's state of arousal that provides protection against BC. On the other hand, there were many missing links in the BC group of women; the clone which lost more links in the BC group was the hub 24, which point to some of the antigens of T47D as potentially useful as vaccines, as the immune system of women with BBP is well aware of them.
authors.affiliation: Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, México.
authors.forename: Tania
authors.initials: T
authors.lastname: Romo-González
authors.affiliation: Programa de Investigación de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Distrito Federal, México.
authors.forename: Marcela
authors.initials: M
authors.lastname: Esquivel-Velázquez
authors.affiliation: Programa de Investigación de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Distrito Federal, México.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ostoa-Saloma
authors.affiliation: Hospital General de México, Secretaría de Salubridad y Asistencia, Distrito Federal, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Lara
authors.affiliation: Programa de Investigación de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Distrito Federal, México.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Zentella
authors.affiliation: Instituto de Investigaciones Biológicas, Universidad Veracruzana, Xalapa, Veracruz, México.
authors.forename: Rosalba
authors.initials: R
authors.lastname: León-Díaz
authors.affiliation: Programa de Investigación de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Distrito Federal, México.
authors.forename: Edmundo
authors.initials: E
authors.lastname: Lamoyi
authors.affiliation: Programa de Investigación de Cáncer de Mama, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Distrito Federal, México.
authors.forename: Carlos
authors.initials: C
authors.lastname: Larralde
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000937:Antigen-Antibody Reactions / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast / Q000276:immunology* / Q000473:pathology; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000276:immunology / Q000473:pathology; D018275:Carcinoma, Lobular / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D053263:Gene Regulatory Networks; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D055815:Young Adult
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D007075:Immunoglobulin M