title: Full genome analysis of a European-type genotype 3 hepatitis E virus variant obtained from a Japanese patient with autochthonous acute hepatitis E.
abstract: A unique European-type HEV strain (HE-JA12-0725) classifiable into subgenotype 3f was recovered from a 66-year-old Japanese female with autochthonous acute hepatitis E, and its entire genomic sequence was determined and characterized. The HE-JA12-0725 strain shared the highest identity of 92.7% with a Spanish swine isolate (EU723514) over the entire genome and possessed a long hypervariable region sequence of 111 amino acids, identical to the 3f strains of European origin. The patient had consumed pork liver obtained via home delivery in Japan approximately two months before the disease onset. These results suggest the circulation of rare 3f HEV strains in Japan.
authors.affiliation: Department of Gastroenterology, Isesaki Municipal Hospital, Isesaki, Gunma-Ken, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.forename: Daichi
authors.initials: D
authors.lastname: Takizawa
authors.forename: Masanobu
authors.initials: M
authors.lastname: Yamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okamoto
mesh_terms: D000820:Animal Diseases / Q000821:virology; D000818:Animals; D005060:Europe; D005814:Genes, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D005838:Genotype; D016751:Hepatitis E / Q000175:diagnosis / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics*; D006801:Humans; D007564:Japan; D010802:Phylogeny
keywords: autoimmune hepatitis; genotype; hepatitis viruses; hypervariable region; phylogenetic tree