title: Semi-stochastic cell-level computational modelling of cellular forces: application to contractures in burns and cyclic loading.
abstract: A phenomenological model is formulated to model cellular forces on extracellular material. The model is capable of modelling both expansion and contractile forces. This work is based on the assumption of linear elasticity, which allows a superposition argument to arrive at fundamental expressions for cellular forces. It is also shown how the cellular forces can be implemented using different strategies, as well as an extension to cellular point sources. Illustrations are given for modelling a (permanent) contraction (e.g. a contracture) of burns and for cyclic loading by the cells.
authors.affiliation: Delft Institute of Applied Mathematics, Delft University of Technology, Delft, The Netherlands. F.J.Vermolen@tudelft.nl.
authors.forename: F J
authors.initials: FJ
authors.lastname: Vermolen
authors.affiliation: Department of Biomedical Engineering, Tel Aviv University, 69978, Tel Aviv, Israel. gefen@eng.tau.ac.il.
authors.forename: A
authors.initials: A
authors.lastname: Gefen
mesh_terms: D002056:Burns / Q000473:pathology / Q000503:physiopathology*; D019245:Compressive Strength; D003198:Computer Simulation; D055119:Elastic Modulus; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D015233:Models, Statistical; D012867:Skin / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology; D013269:Stochastic Processes; D013314:Stress, Mechanical; D013718:Tensile Strength; D014945:Wound Healing / Q000502:physiology*
keywords: Burns; Cell-level modeling; Cellular forces; Contractors; Semi-stochastic model