title: Distinct malignant behaviors of mouse myogenic tumors induced by different oncogenetic lesions.
abstract: Rhabdomyosarcomas (RMS) are heterogeneous cancers with myogenic differentiation features. The cytogenetic and mutational aberrations in RMS are diverse. This study examined differences in the malignant behavior of two genetically distinct and disease-relevant mouse myogenic tumor models. Kras; p1619(null) myogenic tumors, initiated by expression of oncogenic Kras in p16p19(null) mouse satellite cells, were metastatic to the lungs of the majority of tumor-bearing animals and repopulated tumors in seven of nine secondary recipients. In contrast, SmoM2 tumors, initiated by ubiquitous expression of a mutant Smoothened allele, did not metastasize and repopulated tumors in 2 of 18 recipients only. In summary, genetically distinct myogenic tumors in mice exhibit marked differences in malignant behavior.
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg , Freiburg , Germany ; Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.
authors.forename: Simone
authors.initials: S
authors.lastname: Hettmer
authors.affiliation: Department of Biomedical Sciences, Tufts University Veterinary School , North Grafton, MA , USA.
authors.forename: Roderick T
authors.initials: RT
authors.lastname: Bronson
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University , Boston, MA , USA ; Howard Hughes Medical Institute , Chevy Chase, MD , USA ; Joslin Diabetes Center , Boston, MA , USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Wagers
keywords: metastasis; myogenic differentiation; rhabdomyosarcoma; transplantation