title: Vasopressin V1a and V1b receptor modulators: a patent review (2012 - 2014).
abstract: BACKGROUND
  The vasopressin V1a and V1b receptors are involved in many crucial physiological, reproductive, behavioral and social functions. Consequently, they are also involved in several pathological conditions, thus the ligands capable of selective stimulation/inhibition of these receptors may present therapeutic benefit in a variety of diseases.
  
  
  METHODS
  In this review, the author focuses on the vasopressin V1a and V1b receptors, their biological functions and agonists and antagonists patented in the years 2012 - 2014. This paper is divided according to both the target receptor and the applicant and describes the compounds from the patents along with their biological activity.
  
  
  CONCLUSIONS
  In the recent years, pharmaceutical companies have discovered and patented new compounds which act through vasopressin V1a and/or V1b receptors, both peptide and non-peptide. Among the V1bR antagonists published in the last years, the oxindole derivatives appear to be the most promising drug candidates.
authors.affiliation: University of Gdańsk, Faculty of Chemistry , Wita Stwosza 63, 80-308 Gdańsk , Poland magdalena.slusarz@ug.edu.pl.
authors.forename: Magdalena J
authors.initials: MJ
authors.lastname: Ślusarz
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology*; D001127:Arginine Vasopressin / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D000078183:Oxindoles; D010330:Patents as Topic; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D017483:Receptors, Vasopressin / Q000187:drug effects* / Q000378:metabolism
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D007211:Indoles; D008024:Ligands; D000078183:Oxindoles; D010455:Peptides; D017483:Receptors, Vasopressin; C022960:2-oxindole; D001127:Arginine Vasopressin
keywords: agonist; antagonist; vasopressin; vasopressin receptor