title: Poly(ADP-ribose)--a unique natural polymer structural features, biological role and approaches to the chemical synthesis.
abstract: Poly(ADP-ribose) (PAR) is a natural polymer, taking part in numerous important cellular processes. Several enzymes are involved in biosynthesis and degradation of PAR. One of them, poly(ADP-ribose)polymerase-1 (PARP-1) is considered to be a perspective target for the design of new drugs, affecting PAR metabolism. The structure of PAR was established by enzymatic hydrolysis and further analysis of the products, but total chemical synthesis of PAR hasn't been described yet. Several approaches have been developed on the way to chemical synthesis of this unique biopolymer.
authors.affiliation: a Engelhardt Institute of Molecular Biology, Russian Academy of Sciences , Moscow , Russian Federation.
authors.forename: Mikhail S
authors.initials: MS
authors.lastname: Drenichev
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Mikhailov
mesh_terms: D001665:Binding Sites; D001688:Biological Products; D001704:Biopolymers; D053898:Biosynthetic Pathways; D002986:Clinical Trials as Topic; D006801:Humans; D015394:Molecular Structure; D011064:Poly Adenosine Diphosphate Ribose / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D055672:Static Electricity
chemical_list: D001688:Biological Products; D001704:Biopolymers; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases
keywords: DNA alkylation; bioconjugates; enzyme inhibition; modified nucleosides; nucleic acid biosynthesis; nucleotide excision and repair