title: Zebrafish mutants of the neuromuscular junction: swimming in the gene pool.
abstract: This review provides an overview of zebrafish mutants with dysfunctional acetylcholine receptors or related proteins at the neuromuscular junction (NMJ). The NMJ, which has served as the classical model of the chemical synapse, uses acetylcholine as the neurotransmitter, and mutations of proteins involved in the signaling cascade lead to a variety of behavioral phenotypes. Mutants isolated after random chemical mutagenesis screening are summarized, and advances in the field resulting from these mutants are discussed.
authors.affiliation: Department of Physiology, Osaka Medical College, Takatsuki, 569-8686, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Daikoku
authors.forename: Masahisa
authors.initials: M
authors.lastname: Saito
authors.forename: Fumihito
authors.initials: F
authors.lastname: Ono
mesh_terms: D000818:Animals; D009124:Muscle Proteins / Q000502:physiology; D009154:Mutation; D009469:Neuromuscular Junction / Q000235:genetics* / Q000502:physiology; D010641:Phenotype; D011950:Receptors, Cholinergic / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D013550:Swimming / Q000502:physiology; D015027:Zebrafish / Q000235:genetics* / Q000502:physiology; D029961:Zebrafish Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D009124:Muscle Proteins; D011950:Receptors, Cholinergic; D029961:Zebrafish Proteins; C051609:peripheral membrane protein 43K