title: Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives.
abstract: A new series of benzoxazine-6-sulfonamide derivatives were synthesized in excellent yields and the resulting compounds were evaluated for their antimicrobial activities. All the synthesized compounds were assessed for their antibacterial and antifungal activities. Among them 1a, 1b, 1c, 1e, 1h, 2c, 2d, 2e, 2g, 2h, 2i, 2j, 2k and 2l showed low inhibitory concentration (MIC of 31.25 and 62.5 μg/mL) against Gram-positive bacteria, Gram-negative bacteria and fungi, which are comparable to the inhibitory effect of standard drugs.
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
authors.forename: Saidulu
authors.initials: S
authors.lastname: Konda
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
authors.forename: Srujana
authors.initials: S
authors.lastname: Raparthi
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
authors.forename: K
authors.initials: K
authors.lastname: Bhaskar
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Munaganti
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
authors.forename: Vijayacharan
authors.initials: V
authors.lastname: Guguloth
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India. Electronic address: lnagarapuiict@yahoo.com.
authors.forename: Lingaiah
authors.initials: L
authors.lastname: Nagarapu
authors.affiliation: Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India. Electronic address: dattatray.akkewar@gmail.com.
authors.forename: Dattatray M
authors.initials: DM
authors.lastname: Akkewar
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D048588:Benzoxazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D048588:Benzoxazines; D013449:Sulfonamides
keywords: Antibacterial activity; Antifungal activity; Benzoxazine; Piperazine; Sulfonamide