title: Imported visceral leishmaniasis - unexpected bone marrow diagnosis in a patient with fever, pancytopenia, and splenomegaly.
abstract: Leishmaniasis is spreading from mediterranean countries to the north of Europe. The Alps are not an endemic region and there are only few reports of sporadic cases. We report the case of a 72 year old male who presented after a syncope with fever, cough and a sacral skin rash. Clinical examination revealed splenomegaly, elevated liver enzymes and pancytopenia; differential diagnosis included myeloproliferative or lymphoproliferative disorders, infections and auto-immune conditions that cause enlargement of the spleen and liver diseases, however, all tests were negative. In (18)FDG PET computerized tomography, pathological and diffuse uptake in the spleen was seen, with mild and homogeneous FDG uptake in the bone marrow and normal tracer uptake elsewhere in the body. Bone marrow aspiration revealed the presence of numerous intra- and extracellular Leishmania amastigotes. Travel history indicated that he had been in Sardinia for a 7-day vacation several months ago. The patient promptly responded to treatment with liposomal amphotericin B. Imported visceral leishmaniasis is likely to be seen more frequently in non-endemic regions and fever, pancytopenia and splenomegaly are diagnostic clues, whereas diagnostic confirmation may be done by detection of Leishmania spp. amastigotes in the bone marrow.
authors.affiliation: Department of Internal Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Gallina
authors.affiliation: Department of Infectious Disease, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Binazzi
authors.affiliation: Department of Nuclear Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.
authors.forename: Arber
authors.initials: A
authors.lastname: Golemi
authors.affiliation: Department of Nuclear Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Farsad
authors.affiliation: Department of Internal Medicine VI, Medical University of Innsbruck Innsbruck (Tyrol), Austria.
authors.forename: Günter
authors.initials: G
authors.lastname: Weiss
authors.affiliation: Department of Internal Medicine, Central Hospital of Bolzano/Bozen Bolzano/Bozen (BZ), Italy.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Wiedermann
keywords: Immunocompetent; hypersplenism; imaging; imported; visceral leishmaniasis