title: Amphiphilic p-sulfonatocalix[4]arene as "drug chaperone" for escorting anticancer drugs.
abstract: Supramolecularly constructing multifunctional platform for drug delivery is a challenging task. In this work, we propose a novel supramolecular strategy "drug chaperone", in which macrocyclic amphiphiles directly coassemble with cationic drugs into a multifunctional platform and its surface is further decorated with targeting ligands through host-guest recognition. The coassembling and hierarchical decoration processes were monitored by optical transmittance measurements, and the size and morphology of amphiphilic coassemblies were identified by dynamic light scattering and high-resolution transmission electron microscopy. In cell experiments to validate the drug chaperone strategy, the anticancer activities of free drugs were pronouncedly improved by coassembling with amphiphilic chaperone and further functionalization with targeting ligand.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Wang
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Guo
authors.affiliation: College of Life Sciences, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.
authors.forename: Yong-Chao
authors.initials: YC
authors.lastname: Duan
authors.affiliation: College of Life Sciences, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, P. R. China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D047250:Calixarenes; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D006801:Humans; D010636:Phenols; D013501:Surface-Active Agents
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010636:Phenols; D013501:Surface-Active Agents; C511968:p-sulfonatocalix(4)arene; D047250:Calixarenes