title: AD8 Informant Questionnaire for Cognitive Impairment: Pragmatic Diagnostic Test Accuracy Study.
abstract: The diagnostic accuracy of the AD8 informant questionnaire for cognitive impairment was assessed in patients referred to a dedicated memory clinic. This pragmatic prospective study of consecutive referrals attending with an informant who completed AD8 (n = 212) lasted 12 months. Diagnosis used standard clinical diagnostic criteria for dementia and mild cognitive impairment as reference standard (prevalence of cognitive impairment = 0.62). The AD8 proved acceptable to informants, was quick, and easy to use. Using the cutoff of ≥2/8, AD8 was highly sensitive (0.97) for diagnosis of cognitive impairment but specificity was poor (0.17). Combining AD8 with either the Mini-Mental State Examination or the Six-Item Cognitive Impairment Test showed little additional diagnostic benefit. In conclusion, AD8 is very sensitive for cognitive impairment in a memory clinic but specificity may be inadequate.
authors.affiliation: Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, United Kingdom a.larner@thewaltoncentre.nhs.uk.
authors.forename: A J
authors.initials: AJ
authors.lastname: Larner
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D060825:Cognitive Dysfunction / Q000175:diagnosis; D003704:Dementia / Q000523:psychology; D003955:Diagnostic Tests, Routine; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008609:Mental Status Schedule / Q000592:standards; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires
keywords: 6CIT; AD8; MMSE; dementia; diagnosis; memory clinic