title: A two layers monodomain model of cardiac electrophysiology of the atria.
abstract: Numerical simulations of the cardiac electrophysiology in the atria are often based on the standard bidomain or monodomain equations stated on a two-dimensional manifold. These simulations take advantage of the thinness of the atrial tissue, and their computational cost is reduced, as compared to three-dimensional simulations. However, these models do not take into account the heterogeneities located in the thickness of the tissue, like discontinuities of the fiber direction, although they can be a substrate for atrial arrhythmia (Hocini et al., Circulation 105(20):2442-2448, 2002; Ho et al., Cardiovasc Res 54(2):325-336, 2002; Nattel, Nature 415(6868):219-226, 2002). We investigate a two-dimensional model with two coupled, superimposed layers that allows to introduce three-dimensional heterogeneities, but retains a reasonable computational cost. We introduce the mathematical derivation of this model and error estimates with respect to the three-dimensional model. We give some numerical illustrations of its interest: we numerically show its convergence for vanishing thickness, introduce an optimization process of the coupling coefficient and assess its validity on physiologically relevant geometries. Our model would be an efficient tool to test the influence of three-dimensional fiber direction heterogeneities in reentries or atrial arrhythmia without using three-dimensional models.
authors.affiliation: Université Bordeaux 1 & Inria Carmen & IHU Liryc, 200 avenue de la Vieille Tour, 33 405, Talence Cedex, France. yves.coudiere@inria.fr.
authors.forename: Yves
authors.initials: Y
authors.lastname: Coudière
authors.affiliation: Université Bordeaux 1 & Inria Carmen & IHU Liryc, 200 avenue de la Vieille Tour, 33 405, Talence Cedex, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Henry
authors.affiliation: Université Bordeaux Segalen & Inria Carmen & IHU Liryc, 200 avenue de la Vieille Tour, 33 405, Talence Cedex, France. simon.labarthe@u-bordeaux2.fr.
authors.forename: Simon
authors.initials: S
authors.lastname: Labarthe
mesh_terms: D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D016275:Atrial Function; D003198:Computer Simulation; D055724:Electrophysiological Phenomena; D006801:Humans; D021621:Imaging, Three-Dimensional; D055641:Mathematical Concepts; D008955:Models, Cardiovascular
keywords: Asymptotic analysis; Atrial model; Cardiac modeling; Surface model