title: Single-Session CT-Guided Percutaneous Microwave Ablation of Bilateral Adrenal Gland Hyperplasia Due to Ectopic ACTH Syndrome.
abstract: Bilateral adrenalectomy is currently the only available treatment for adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome (ectopic ACTH syndrome) that is refractory to pharmacologic therapy. We describe two patients with refractory ectopic ACTH syndrome who were treated with CT-guided percutaneous microwave ablation of both hyperplastic adrenal glands in a single session: O ne was not a surgical candidate, and the other had undergone unsuccessful surgery. Following the procedure, both patients achieved substantial decreases in serum cortisol, symptomatic improvement, and decreased anti-hypertensive medication requirements.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. ashasarma@gmail.com.
authors.forename: Asha
authors.initials: A
authors.lastname: Sarma
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA. pshyn@partners.org.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Shyn
authors.affiliation: Department of Radiology, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, R3T 2N2, Canada.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Vivian
authors.affiliation: Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
authors.forename: Ju-Mei
authors.initials: JM
authors.lastname: Ng
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
authors.forename: Kemal
authors.initials: K
authors.lastname: Tuncali
authors.affiliation: Department of Medicine, Dana Farber Cancer Institute, 44 Binney St., Boston, MA, 02115, USA.
authors.forename: Jorchen H
authors.initials: JH
authors.lastname: Lorch
authors.affiliation: Department of Endocrinology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA.
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Zaheer
authors.affiliation: Department of Endocrinology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA, 02115, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Gordon
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, 02115, USA.
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Silverman
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000150:complications*; D055011:Ablation Techniques / Q000379:methods*; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D008297:Male; D008872:Microwaves; D015641:Radiography, Interventional; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Adrenal hyperplasia; Cushing’s syndrome; Ectopic ACTH syndrome; Image-guided intervention; Microwave ablation