title: Changing epidemiology of hepatitis C virus genotypes in the central region of Argentina.
abstract: The aim of this study was to analyze the prevalence of hepatitis C virus (HCV) genotypes in Córdoba province, Argentina, over a 12-year period and to study the changes at the molecular level. The HCV genotype was determined in 357 HCV-infected patients, and the phylogeny and demographic reconstruction for HCV-1 was assessed. A significant reduction in HCV-2 prevalence with respect to HCV-1 in Córdoba after 2003 was observed. These findings are consistent with the epidemiological changes observed in South America. Nevertheless, the consequences of these changes remain to be elucidated.
authors.affiliation: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Federico Alejandro
authors.initials: FA
authors.lastname: Di Lello
authors.forename: Adrián Alejandro
authors.initials: AA
authors.lastname: Farias
authors.forename: Andrés Carlos Alberto
authors.initials: AC
authors.lastname: Culasso
authors.forename: Paula Soledad
authors.initials: PS
authors.lastname: Pérez
authors.forename: María Belén
authors.initials: MB
authors.lastname: Pisano
authors.forename: Marta Silvia
authors.initials: MS
authors.lastname: Contigiani
authors.forename: Rodolfo Héctor
authors.initials: RH
authors.lastname: Campos
authors.forename: Viviana Elizabeth
authors.initials: VE
authors.lastname: Ré
mesh_terms: D001118:Argentina / Q000453:epidemiology; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D010802:Phylogeny; D013020:South America / Q000453:epidemiology