title: Increased level of red cell distribution width is associated with poor coronary collateral circulation in patients with stable coronary artery disease.
abstract: OBJECTIVE
  Previous studies have shown the association between various hematological parameters and cardiovascular diseases, and their prognostic value. In this study, we compared red cell distribution width (RDW), neutrophil lymphocyte ratio (NLR) and mean platelet volume (MPV) measurements among patients with poor coronary collateral circulation (CCC) and well-developed CCC.
  
  
  METHODS
  326 patients with stable coronary artery disease (CAD) were evaluated retrospectively. CCC was graded by using the Rentrop classification. The poor CCC group included patients with Rentrop 0-1 CCC, and the good CCC group included Rentrop 2-3 CCC.
  
  
  RESULTS
  There were 171 subjects (84% male; mean age 56.6±10.4 years) in the poor CCC group, and 155 subjects (89% male; mean age 57.6±9.7 years) in the good CCC group. The total number of vessels with >95% stenosis (1.1±0.5 vs. 1.0±0.4; p=0.64) and Gensini scores (84.4±38.8 vs. 83.3±37.4; p=0.83) was not higher in the poor CCC group compared to the good CCC group. RDW was significantly higher in the poor CCC group compared to the good CCC group (14.19±1.36% vs. 13.89±1.19%; p=0.04). In multivariate logistic regression analysis, elevated levels of RDW and LDL were found to be independent predictors of poor CCC (OR 1.73, 95% CI: 1.30-2.29, p=0.01 and OR 1.01 95% CI 1.002-1.02; p=0.02, respectively).
  
  
  CONCLUSIONS
  In the present study, poor CCC was found to be independently correlated with RDW, but not with any other hematological parameters in patients with stable CAD.
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey. medirfansahin@gmail.com.
authors.forename: İrfan
authors.initials: İ
authors.lastname: Şahin
authors.affiliation: Department of Cardiology, İstanbul Medicine Hospital, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karabulut
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbul, Turkey.
authors.forename: Adnan
authors.initials: A
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbul, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Güngör
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: İlhan İlker
authors.initials: İİ
authors.lastname: Avcı
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Okuyan
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbul, Turkey.
authors.forename: Mehmet Mustafa
authors.initials: MM
authors.lastname: Can
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Serhat
authors.initials: S
authors.lastname: Sığırcı
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Ayça
authors.affiliation: Department of Cardiology, Bagcilar Training and Research Hospital, İstanbul, Turkey.
authors.forename: Mustafa Hakan
authors.initials: MH
authors.lastname: Dinçkal
mesh_terms: D000368:Aged; D003097:Collateral Circulation / Q000502:physiology*; D003324:Coronary Artery Disease / Q000097:blood* / Q000503:physiopathology*; D004909:Erythrocyte Indices / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies