title: Single nucleotide polymorphisms in type 2 diabetes among Hispanic adults.
abstract: In this pilot study, we explore the genetic variation that may relate to type 2 diabetes (T2D) among Hispanic adults. The genotypes of 36 Hispanic adults were analyzed by using the Cardio-Metabochip. The goal is to identify single nucleotide polymorphisms (SNPs) associated to T2D among Hispanic adults. A total of 26 SNPs were identified to be associated with T2D among Hispanic adults. None of these SNPs have been reported for T2D. By using the principle components analysis to analyze the genotype of 26 SNPs in 36 samples, the samples obtained from diabetic patients could be distinguished from the control samples. The findings support genetic involvement in T2D among Hispanic adults.
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Watson
authors.affiliation: School of Nursing, University of North Carolina at Greensboro, Greensboro, NC 27402, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC 27412, USA; Department of Nanoscience, Joint School of Nanoscience and Nanoengineering, Greensboro, NC 27401, USA. Electronic address: prof.chiu@gmail.com.
authors.forename: Norman H L
authors.initials: NH
authors.lastname: Chiu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006630:Hispanic or Latino / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D010865:Pilot Projects; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
keywords: Hispanic adults; Single nucleotide polymorphism