title: Genome sequence of a clinical isolate of dermatophyte, Trichophyton rubrum from India.
abstract: Trichophyton rubrum is one of the major causative agents of dermatophytosis in humans worldwide. We report the draft genome sequence of T. rubrum var. raubitschekii from Delhi, India, isolated from a patient presenting symptoms of onychomycosis. The total estimated genome size of the clinical isolate is 25.2 MB containing 8265 predicted protein-coding sequences, 91 tRNA and 15 rRNA genes. Sequence analysis of the secreted subtilases, one of the major virulence factors in dermatophytes, clusters them into three subfamilies with distinct sequence features. The genome sequence is a step in understanding diversity of dermatophytes worldwide and will aid in identification of virulence factors and dissecting mechanisms of pathogenesis among them.
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India Academy of Scientific and Innovative Research, New Delhi 110025, India.
authors.forename: Chitra
authors.initials: C
authors.lastname: Latka
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India Academy of Scientific and Innovative Research, New Delhi 110025, India.
authors.forename: Sanchita Sanchaya
authors.initials: SS
authors.lastname: Dey
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India.
authors.forename: Siddharth
authors.initials: S
authors.lastname: Mahajan
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India.
authors.forename: Ramachandira
authors.initials: R
authors.lastname: Prabu
authors.affiliation: Microbial Biotechnology and Genomics Unit, CSIR-IGIB, New Delhi 110020, India.
authors.forename: Pramod Kumar
authors.initials: PK
authors.lastname: Jangir
authors.affiliation: Department of Microbiology, UCMS & GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Chhavi
authors.initials: C
authors.lastname: Gupta
authors.affiliation: Department of Microbiology, UCMS & GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Shukla
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Microbiology, UCMS & GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Vishnampettai Ganapathysubramanian
authors.initials: VG
authors.lastname: Ramachandran
authors.affiliation: Department of Dermatology, UCMS & GTB Hospital, Dilshad Garden, Delhi 110095, India.
authors.forename: Sambit Nath
authors.initials: SN
authors.lastname: Bhattacharya
authors.affiliation: CSIR Ayurgenomics Unit - TRISUTRA, CSIR-IGIB, New Delhi 110020, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Pandey
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi 110025, India Microbial Biotechnology and Genomics Unit, CSIR-IGIB, New Delhi 110020, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India Academy of Scientific and Innovative Research, New Delhi 110025, India.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Ramachandran
authors.affiliation: Genome Informatics and Structural Biology Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi 110020, India Academy of Scientific and Innovative Research, New Delhi 110025, India btaneja@igib.res.in.
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Taneja
mesh_terms: D003883:Arthrodermataceae / Q000235:genetics; D001483:Base Sequence; D016681:Genome, Fungal; D006801:Humans; D007194:India; D008969:Molecular Sequence Data; D014009:Onychomycosis / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D014249:Trichophyton / Q000235:genetics*
keywords: Trichophyton rubrum var. raubitschekii; dermatophytosis; filamentous fungi; next-generation sequencing; subtilisin proteases