title: Oral hybrid verrucous carcinoma: a clinical study.
abstract: Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p = 0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis.
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Gokavarapu
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: L M Chandrasekhara
authors.initials: LM
authors.lastname: Rao S
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: Uma Sankar
authors.initials: US
authors.lastname: Tantravahi
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: Sandhya Devi
authors.initials: SD
authors.lastname: Gundimeda
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: T Subramaneshwar
authors.initials: TS
authors.lastname: Rao
authors.affiliation: Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, Andhra Pradesh pin - 500034 India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Murthy
keywords: Hybrid verrucous carcinoma; Oral cancer; Verrucous carcinoma