title: FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.
abstract: Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle-stimulating hormone (FSH), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle-stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo. The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as a result, Ca(2+) influx is stimulated, cAMP-response-element-binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of FSH receptor-mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.
authors.affiliation: International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, Zhejiang, China; Shanghai Jiao Tong University - The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases, Shanghai, China.
authors.forename: Xin-Mei
authors.initials: XM
authors.lastname: Liu
authors.forename: Hsiao Chang
authors.initials: HC
authors.lastname: Chan
authors.forename: Guo-Lian
authors.initials: GL
authors.lastname: Ding
authors.forename: Jie
authors.initials: J
authors.lastname: Cai
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Mei Kuen
authors.initials: MK
authors.lastname: Yu
authors.forename: Yan-Ting
authors.initials: YT
authors.lastname: Wu
authors.forename: Fan
authors.initials: F
authors.lastname: Qu
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Yong-Chao
authors.initials: YC
authors.lastname: Lu
authors.forename: Eli Y
authors.initials: EY
authors.lastname: Adashi
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Sheng
authors.forename: He-Feng
authors.initials: HF
authors.lastname: Huang
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000368:Aged; D000375:Aging / Q000502:physiology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010766:Phosphorylation; D011962:Receptors, FSH / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D002118:Calcium
keywords: ageing; ca2+; endocrinology; mouse models; signal transduction; signalling