title: Scaffolds from surgically removed kidneys as a potential source of organ transplantation.
abstract: End stage renal disease (ESRD) is a common disease, which relates to nearly 600 million people in the total population. What is more, it seems to be a crucial problem from the epidemiological point of view. These facts lead to a further necessity of renal replacement therapy development connected with rising expenditures for the health care system. The aim of kidney tissue engineering is to develop and innovate methods of obtaining renal extracellular matrix (ECM) scaffolds derived from kidney decellularization. Recently, progress has been made towards developing a functional kidney graft in vitro on demand. In fact, decellularized tissues constitute ideal natural scaffolds, due to the preservation of native ECM architecture, as well as of cell-ECM binding domains critical in promoting cell attachment, migration, and proliferation. One of the potential sources of the natural scaffolds is the kidney, which cannot be transplanted immediately after excision.
authors.affiliation: Department of Transplantology, General, Vascular and Plastic Surgery, Clinical Hospital of Poznan University of Medical Sciences, 60-780 Poznan, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Karczewski
authors.affiliation: Clinical Hospital of Poznan University of Medical Sciences, 60-780 Poznan, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Malkiewicz
mesh_terms: D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000502:physiology / Q000601:surgery; D016030:Kidney Transplantation; D023822:Tissue Engineering; D054457:Tissue Scaffolds