title: Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression.
abstract: The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.
authors.affiliation: Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Fan
authors.affiliation: Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Yan
keywords: Xingnao Jieyu capsule; hippocampus; neural regeneration; neuron; poststroke depression; traditional Chinese medicine