title: Synthesis and crystal structure of new heterocyles derived from saccharin and uracil carrying 1,2,4-oxadiazolylmethyl group.
abstract: Saccharin, uracil, and 1,2,4-oxadiazole heterocyles are important in terms of exhibiting various biological acitivities. In this work, four series of 1,2,4-oxadiazolylmethyl-substituted saccharin, and uracil derivatives are synthesized and their structures are identified by means of spectral/physical characteristics. The first series are oxadiazolylmethyl-substituted saccharins. The second one is oxadiazole-substituted uracils which are obtained as a separable mixture of both mono- and bis-substituted end products. Third series is obtained from 5-amino uracil and chloromethyl oxadiazoles. The fourth group is oxadiazolyl methyl-substituted imino uracils. The structures of some title compounds are also confirmed by X-ray diffraction data.
authors.affiliation: Department of Chemistry, Abant İzzet Baysal University, 14280, Bolu, Turkey, yasardurust@ibu.edu.tr.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Dürüst
authors.forename: Besra
authors.initials: B
authors.lastname: Özer
authors.forename: Benson M
authors.initials: BM
authors.lastname: Kariuki
authors.forename: Benson M
authors.initials: BM
authors.lastname: Cariuki
mesh_terms: D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D012439:Saccharin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D014498:Uracil; D012439:Saccharin