title: IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis.
abstract: The interferon-inducible transmembrane protein 3 (IFITM3), as one of the key genes involved in the interferon pathway, is critical for defending the host against influenza virus, and the rs12252 T>C variant in IFITM3 might be associated with susceptibility to severe influenza. Owing to contradictory and inconclusive results, we performed a meta-analysis to assess the association between rs12252 T>C polymorphism and severe influenza risk. A comprehensive literature search up to 1 August 2014 was conducted in EMBASE, Pubmed, Web of Science, VIP, Wanfang and CNKI databases. Four eligible studies with a total of 445 influenza patients and 3396 controls were included in this meta-analysis. Overall, our results demonstrated a significant association between the IFITM3 rs12252 T>C polymorphism and influenza risk [C vs. T: odds ratio (OR) 1·68, 95% confidence interval (CI) 1·32-2·13; CC vs. CT+TT: OR 2·38, 95% CI 1·52-3·73; CC+CT vs. TT: OR 1·62, 95% CI 1·18-2·22]. Stratification by ethnicity indicated that the variant C allele was associated with an 88% increased risk of influenza in Asians (C vs. T: OR 1·88, 95% CI 1·34-2·62). Moreover, subjects carrying the variant C allele had an increased risk of developing severe illness upon influenza infection (C vs. T: OR 2·70, 95% CI 1·86-3·94). However, no significant association was observed in patients with mild infection (C vs. T: OR 1·26, 95% CI 0·93-1·71). Our meta-analysis suggests that IFITM3 rs12252 T>C polymorphism is significantly associated with increased risk of severe influenza but not with the chance of initial virus infection.
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xuan
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: L N
authors.initials: LN
authors.lastname: Wang
authors.affiliation: Department of Infectious Disease Prevention and School Health,Nanjing Municipal Center for Disease Control and Prevention,Jiangsu,China.
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: H R
authors.initials: HR
authors.lastname: Zi
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Yan
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: X B
authors.initials: XB
authors.lastname: Chen
authors.affiliation: Key Laboratory of Environmental Medicine Engineering,Ministry of Education,Department of Epidemiology & Biostatistics,School of Public Health,Southeast University,Nanjing,China.
authors.forename: P M
authors.initials: PM
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007251:Influenza, Human / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D016601:RNA-Binding Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: C080082:IFITM3 protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
keywords: IFITM3; influenza; meta-analysis; polymorphism