title: Organic anxiety in a woman with breast cancer receiving denosumab.
abstract: Hypocalcemia can induce heterogeneous psychiatric manifestations, and its etiology can be multifactorial. Herein, we describe a patient who had previously undergone resection of parathyroid glands, who presented with extreme anxiety and hypocalcemia after denosumab treatment for cancer-related bone metastasis. The anxiety subsided soon after correction of her serum calcium level. When denosumab is prescribed for patients with predisposing factors of hypocalcemia, such as hypoparathyroidism, clinicians should be aware of symptomatic hypocalcemia.
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Douliu City, Yunlin County, Taiwan.
authors.forename: Kuan-Fu
authors.initials: KF
authors.lastname: Lin
authors.affiliation: Department of Oncology, National Taiwan University Hospital, Yun-Lin Branch, Douliu City, Yunlin County, Taiwan.
authors.forename: Kuo-Hsing
authors.initials: KH
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, National Taiwan University Hospital, Yun-Lin Branch, Douliu City, Yunlin County, Taiwan; Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei City, Taiwan. Electronic address: weiliehhuang@gmail.com.
authors.forename: Wei-Lieh
authors.initials: WL
authors.lastname: Huang
mesh_terms: D001008:Anxiety Disorders / Q000139:chemically induced*; D050071:Bone Density Conservation Agents / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D000069448:Denosumab / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000139:chemically induced / Q000150:complications* / Q000209:etiology; D007011:Hypoparathyroidism / Q000150:complications; D008875:Middle Aged
chemical_list: D050071:Bone Density Conservation Agents; D000069448:Denosumab
keywords: Denosumab; Hypocalcemia; Hypoparathyroidism; Organic anxiety