title: Association between the interleukin-6 gene polymorphisms and renal cancer risk.
abstract: BACKGROUND
  Interleukin-6 (IL-6), a central proinflammatory cytokine, may be involved in the host response to cancer. We therefore aimed to evaluate the association of the IL-6 gene polymorphisms at positions -174 and -572 with predisposition to renal cancer.
  
  
  METHODS
  We conducted a hospital-based case-control study. A total of 432 subjects, including 216 pathologically-proven renal cancer cases and 216 age- and gender-matched healthy controls, were recruited in this study. Polymorphism for the IL-6 gene was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Patients with renal cancer had a significantly higher frequency of IL-6 -174 CC genotype [odds ratio (OR)=2.08, 95% confidence interval (CI)=1.05, 4.13; P=0.04] than healthy controls. When stratifying by the grade, patients with higher grade (grade 3 or 4) renal cancer had a significantly higher frequency of IL-6 -174 CC genotype (OR=2.33, 95% CI=1.04, 5.23; P=0.04).
  
  
  CONCLUSIONS
  This study is, to our knowledge, the first to examine prospectively an increased risk role of IL-6 -174 CC genotype in renal cancer susceptibility.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: ZhiHong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: ZhiHong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Urology, The Second People's Hospital of Sichuan, Chengdu 610041, China.
authors.forename: YingMing
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: You
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: ypinglu@hotmail.com.
authors.forename: YiPing
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D015850:Interleukin-6
keywords: Gene polymorphism; Interleukin-6; Renal cancer