title: Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma.
abstract: BACKGROUND
  Glioma is the most devastating type of malignant brain tumors in adults. Genetic factors play important roles in the pathogenesis of glioma. In recent years, some studies found that there were significant association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma susceptibility, however, the results were controversial. The aim of this study was to obtain a more exact estimation of the association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma through a meta-analysis.
  
  
  METHODS
  The meta-analysis included 19 published case-control studies involving 8541 cases and 14226 controls. The included papers were searched from PubMed and Embase database. Odds ratio (OR) with 95% confidence interval (95% CI) were used to evaluate the association of regulator of telomere elongation helicase 1 rs6010620 polymorphism with glioma.
  
  
  RESULTS
  A significant association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma susceptibility was observed for GG vs. AA+AG (OR=1.28, 95% CI=1.14-1.43) and G vs. A (OR=1.07, 95% CI=1.03-1.10). Further subgroup analysis based on ethnicity showed similar results in Asians and Caucasians. In the subgroup analysis of source of control, a significant association between the G allele and glioma susceptibility were found in population-based group and hospital-based group.
  
  
  CONCLUSIONS
  The meta-analysis suggested that regulator of telomere elongation helicase 1 rs6010620 polymorphism was a risk factor for glioma. And this study also suggested that rs6010620 GG genotype and G allele may be indicators for the risk of glioma.
authors.affiliation: Department of Anesthesiology, Chinese PLA 251 Hospital Zhangjiakou, China ; Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
authors.forename: Shujun
authors.initials: S
authors.lastname: Pei
authors.affiliation: Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
authors.forename: Junle
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Chinese PLA General Hospital Beijing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of General Surgery, Chinese PLA 251 Hospital Zhangjiakou, China.
authors.forename: Peizhong
authors.initials: P
authors.lastname: Shang
keywords: Regulator of telomere elongation helicase 1; glioma; polymorphism; susceptibility