title: Reviewing the recommendations for lupus in children.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder with severe morbidity and mortality and diverse systemic involvement. Disease onset occurs during childhood in approximately 15 % of patients with SLE. It is important to treat the attacks adequately and prevent further flares for favorable long-term outcomes. The aim of effective disease management with early immunosuppression is to achieve symptomatic resolution and improvement in the quality of life by maintaining sustained remission and thereby preventing tissue damage. Adult literature on SLE management has evolved considerably over the past few decades based on observations from clinical studies investigating different immunosuppressive agents. We lack well-designed randomized controlled trials in children with SLE, thus we mainly depend on adult literature. Here, we review the literature for the current management of SLE in children and we present the recommendations and suggestions with the level of evidence.
authors.affiliation: Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, 06100, Turkey.
authors.forename: Zehra Serap
authors.initials: ZS
authors.lastname: Arıcı
authors.forename: Ezgi Deniz
authors.initials: ED
authors.lastname: Batu
authors.forename: Seza
authors.initials: S
authors.lastname: Ozen
mesh_terms: D002648:Child; D019468:Disease Management; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D011788:Quality of Life
chemical_list: D007166:Immunosuppressive Agents