title: The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice.
abstract: Portulaca oleracea L. (PO) is known as "a vegetable for long life" due to its antioxidant, anti-inflammatory, and other pharmacological activities. However, the protective activity of the ethanol extract of PO (EEPO) against hypoxia-induced pulmonary edema has not been fully investigated. In this study, we exposed mice to a simulated altitude of 7000 meters for 0, 3, 6, 9, and 12 h to observe changes in the water content and transvascular leakage of the mouse lung. It was found that transvascular leakage increased to the maximum in the mouse lung after 6 h exposure to hypobaric hypoxia. Prophylactic administration of EEPO before hypoxic exposure markedly reduced the transvascular leakage and oxidative stress, and inhibited the upregulation of NF-kB in the mouse lung, as compared with the control group. In addition, EEPO significantly reduced the levels of proinflammatory cytokines and cell adhesion molecules in the lungs of mice, as compared with the hypoxia group. Our results show that EEPO can reduce initial transvascular leakage and pulmonary edema under hypobaric hypoxia conditions.
authors.affiliation: 1 Department of Military Hygiene, Faculty of Naval Medicine, Second Military Medical University , Shanghai, PR China .
authors.forename: Tan
authors.initials: T
authors.lastname: Yue
authors.forename: Wen
authors.initials: W
authors.lastname: Xiaosa
authors.forename: Qi
authors.initials: Q
authors.lastname: Ruirui
authors.forename: Shi
authors.initials: S
authors.lastname: Wencai
authors.forename: Xin
authors.initials: X
authors.lastname: Hailiang
authors.forename: Li
authors.initials: L
authors.lastname: Min
mesh_terms: D000532:Altitude Sickness / Q000150:complications / Q000378:metabolism*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000187:drug effects; D016207:Cytokines / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D031822:Portulaca / Q000737:chemistry*; D011654:Pulmonary Edema / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013997:Time Factors
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D016328:NF-kappa B; D010936:Plant Extracts
keywords: Portulaca oleracea; hypoxia; nuclear factor kappa B; oxidative stress; pulmonary edema