title: Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats.
abstract: Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Gong
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Pan
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Sai
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Luyan
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Junbin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Qinyin
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Guoyin
authors.initials: G
authors.lastname: Xiong
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Institute of Brain Research, Medical College of Jinan University, Guangzhou 510632, Guangdong Province, China ; Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong, Guangzhou 510632, Guangdong Province, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
keywords: caspase-3; curcumin; gp120 V3 loop; hippocampal neurons; human immunodeficiency virus-associated neurocognitive function; mitochondrial membrane potential; neural regeneration