title: Toward multifunctional "clickable" diamond nanoparticles.
abstract: Nanodiamonds (NDs) are among the most promising new carbon based materials for biomedical applications, and the simultaneous integration of various functions onto NDs is an urgent necessity. A multifunctional nanodiamond based formulation is proposed here. Our strategy relies on orthogonal surface modification using different dopamine anchors. NDs simultaneously functionalized with triethylene glycol (EG) and azide (-N3) functions were fabricated through a stoichiometrically controlled integration of the dopamine ligands onto the surface of hydroxylated NDs. The presence of EG functionalities rendered NDs soluble in water and biological media, while the -N3 group allowed postsynthetic modification of the NDs using "click" chemistry. As a proof of principle, alkynyl terminated di(amido amine) ligands were linked to these ND particles.
authors.affiliation: †Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.
authors.forename: Manakamana
authors.initials: M
authors.lastname: Khanal
authors.affiliation: †Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.|‡Taras Shevchenko University, 60 Vladimirskaya str., Kiev, Ukraine.|§Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A) (FRE 3517-CNRS), Université de Picardie Jules Verne, 33 Rue St Leu, 80039 Amiens, France.
authors.forename: Volodymyr
authors.initials: V
authors.lastname: Turcheniuk
authors.affiliation: †Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Barras
authors.affiliation: §Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A) (FRE 3517-CNRS), Université de Picardie Jules Verne, 33 Rue St Leu, 80039 Amiens, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Rosay
authors.affiliation: §Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A) (FRE 3517-CNRS), Université de Picardie Jules Verne, 33 Rue St Leu, 80039 Amiens, France.
authors.forename: Omprakash
authors.initials: O
authors.lastname: Bande
authors.affiliation: §Laboratoire de Glycochimie des Antimicrobiens et des Agroressources (LG2A) (FRE 3517-CNRS), Université de Picardie Jules Verne, 33 Rue St Leu, 80039 Amiens, France.
authors.forename: Aloysius
authors.initials: A
authors.lastname: Siriwardena
authors.affiliation: ‡Taras Shevchenko University, 60 Vladimirskaya str., Kiev, Ukraine.|∥Chemistry Department, Pontifical Catholic University of Rio de Janeiro, Rua Marques de Sao Vicente, 225-Gavea, Rio de Janeiro, 22451-900, Brazil.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zaitsev
authors.affiliation: ⊥State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, 3888 Dong Nanhu Road, Changchun 130033, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Pan
authors.affiliation: †Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.
authors.forename: Rabah
authors.initials: R
authors.lastname: Boukherroub
authors.affiliation: †Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR-CNRS 8520, Université Lille 1, Cité Scientifique, 59655 Villeneuve d'Ascq, France.
authors.forename: Sabine
authors.initials: S
authors.lastname: Szunerits
mesh_terms: D001386:Azides / Q000737:chemistry; D058612:Nanodiamonds / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D013499:Surface Properties
chemical_list: D001386:Azides; D058612:Nanodiamonds; C028914:triethylene glycol; D011092:Polyethylene Glycols