title: Treating cutaneous T-cell lymphoma with highly irregular surfaces with photon irradiation using rice as tissue compensator.
abstract: OBJECTIVE
  Cutaneous T-cell lymphoma (CTCL) is known to have an excellent response to radiotherapy, an important treatment modality for this disease. In patients with extremity and digit involvement, the irregular surface and depth variations create difficulty in delivering a homogenous dose using electrons. We sought to evaluate photon irradiation with rice packing as tissue equivalence and determine clinical tolerance and response.
  
  
  METHODS
  Three consecutive CTCL patients with extensive lower extremity involvement including the digits were treated using external beam photon therapy with rice packing for tissue compensation. The entire foot was treated to 30-40 Gy in 2-3 Gy per fraction using 6 MV photons prescribed to the mid-plane of an indexed box filled with rice in which the foot was placed. Treatment tolerance and response were monitored with clinical evaluation.
  
  
  RESULTS
  All patients tolerated the treatment without treatment breaks. Toxicities included grade 3 erythema and desquamation with resolution within 4 weeks. No late toxicities were observed. All patients had a partial response by 4 weeks after therapy with two patients achieving a complete response. Patients reported improved functionality after treatment. No local recurrence has been observed.
  
  
  CONCLUSIONS
  Tissue compensation with rice packing offers a convenient, inexpensive, and reproducible method for the treatment of CTCL with highly irregular surfaces.
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Lonika
authors.initials: L
authors.lastname: Majithia
authors.affiliation: Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center , Sacramento, CA , USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Rong
authors.affiliation: Department of Radiation Oncology, Henry Ford Health System , Detroit, MI , USA.
authors.forename: Farzan
authors.initials: F
authors.lastname: Siddiqui
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Todd
authors.initials: T
authors.lastname: Hattie
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Nilendu
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Weldon
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Arnab
authors.initials: A
authors.lastname: Chakravarti
authors.affiliation: Division of Dermatology, Department of Internal Medicine, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Henry K
authors.initials: HK
authors.lastname: Wong
authors.affiliation: Division of Hematology, Department of Internal Medicine, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Porcu
authors.affiliation: Department of Radiation Oncology, James Cancer Hospital, The Ohio State University , Columbus, OH , USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu-Welliver
keywords: cutaneous T-cell lymphoma; irregular surface; radiotherapy; tissue compensation