title: Age, gender, and topography influence the clinical and dermoscopic appearance of lentigo maligna.
abstract: BACKGROUND
  Little is known about the frequency of clinical and dermoscopic patterns of lentigo maligna (LM) in relation to specific anatomic subsites and patients characteristics.
  
  
  OBJECTIVE
  We sought to assess the frequency of clinical and dermoscopic features of LM and to correlate them to specific anatomic subsites, and patients' age and gender.
  
  
  METHODS
  This was a retrospective analysis of clinical and dermoscopic images of a series of consecutive, histopathologically diagnosed, facial and extrafacial LM.
  
  
  RESULTS
  A total of 201 cases from 200 patients (mean age 69.51 ± 12.26 years) including 120 women were collected. Most cases were located on the face (n = 192, 95.5%). In 102 cases, LM presented as clinically solitary facial macule (s/LM), whereas it was associated with multiple surrounding freckles in the remaining cases. s/LM were significantly smaller (<10 vs >10 mm; P = .020) and associated with younger age compared with LM associated with multiple surrounding freckles (mean age 67.73 ± 12.68 years vs 71.34 ± 11.59 years, respectively; P = .036). Dermoscopically, gray color irrespective of a specific pattern was the most prevalent finding seen in 178 (88.6%) cases.
  
  
  CONCLUSIONS
  This was a retrospective study.
  
  
  CONCLUSIONS
  The knowledge about patient age, patient gender, and site-related clinical features of LM associated with gray color upon dermoscopy may enhance the clinical recognition of LM.
authors.affiliation: Clinic of Dermatovenereology, Clinical Center of Nis Medical Faculty, University of Nis, Nis, Serbia.
authors.forename: Danica
authors.initials: D
authors.lastname: Tiodorovic-Zivkovic
authors.affiliation: Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Reggio Emilia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.affiliation: Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Reggio Emilia, Italy.
authors.forename: Aimilios
authors.initials: A
authors.lastname: Lallas
authors.affiliation: Lyon 1 University, Dermatology Department, Centre Hospitalier Lyon Sud, Lyon, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Thomas
authors.affiliation: Department of Medical Statistics, Faculty of Medicine, University of Nis, Nis, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Ignjatovic
authors.affiliation: Skin and Cancer Associates, Plantation, Florida.
authors.forename: Harold
authors.initials: H
authors.lastname: Rabinovitz
authors.affiliation: Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Reggio Emilia, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Moscarella
authors.affiliation: Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Reggio Emilia, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
authors.affiliation: Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
authors.forename: Rainer
authors.initials: R
authors.lastname: Hofmann-Wellenhof
authors.affiliation: Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria. Electronic address: iris.zalaudek@gmail.com.
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
mesh_terms: D000367:Age Factors; D000368:Aged; D046169:Dermoscopy; D005153:Facial Neoplasms / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D012737:Sex Factors; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*
keywords: dermoscopy; lentigo maligna