title: CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?
abstract: CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens, while only a small number of circulating leukocytes express this molecule. In this review we will discuss the role of CD69 in mucosal tissue and consider CD69 as a potential target for the development of novel treatments of intestinal inflammation.
authors.affiliation: U1019, Team 7, Institut National de la Santé et de la Recherche Médicale (INSERM), 1 rue du Professeur Calmette, 59019 Lille, France ; Center for Infection and Immunity of Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, France.
authors.forename: Katarina
authors.identifier: 0000-0003-1003-2500
authors.initials: K
authors.lastname: Radulovic
authors.affiliation: Department of Visceral Surgery and Medicine, Inselspital, Freiburgstraße, 3010 Bern, Switzerland.
authors.forename: Jan Hendrik
authors.identifier: 0000-0003-2342-2276
authors.initials: JH
authors.lastname: Niess
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015415:Biomarkers; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D004751:Enteritis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000069196:Gastrointestinal Microbiome / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics; D056747:Immunomodulation; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D037181:Lectins, C-Type / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D058990:Molecular Targeted Therapy; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D037181:Lectins, C-Type; D000099192:CD69 Antigens