title: Dynamic oxygenation measurements using a phosphorescent coating within a mammary window chamber mouse model.
abstract: Phosphorescent lifetime imaging was employed to measure the spatial and temporal distribution of oxygen partial pressure in tissue under the coverslip of a mammary window chamber breast cancer mouse model. A thin platinum-porphyrin coating, whose phosphorescent lifetime varies monotonically with oxygen partial pressure, was applied to the coverslip surface. Dynamic temporal responses to induced modulations in oxygenation levels were measured using this approach.
authors.affiliation: Department of Biomedical Engineering, University of Arizona, 1657 E. Helen St., Tucson, AZ 85721, USA ; Department of Medical Imaging, University of Arizona, 1609 N Warren Ave, Tucson, AZ 85724, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Schafer
authors.affiliation: Department of Biomedical Engineering, University of Arizona, 1657 E. Helen St., Tucson, AZ 85721, USA ; College of Optical Sciences, University of Arizona, 1630 E. University Blvd, Tucson, AZ 85721, USA ; Department of Medical Imaging, University of Arizona, 1609 N Warren Ave, Tucson, AZ 85724, USA.
authors.forename: Arthur F
authors.initials: AF
authors.lastname: Gmitro
keywords: (170.1470) Blood or tissue constituent monitoring; (170.3650) Lifetime-based sensing