title: Inhibitors for cholesterol ester accumulation in macrophages from Chinese cabbage.
abstract: The cholesterol ester accumulates in macrophages in the early stage of atherosclerotic lesions, leading to the formation of foam cells. We examined the inhibitory effects of the crude extracts of 22 edible plants on foam cell formation and isolated nine chlorophyll derivatives as potent inhibitors from Chinese cabbage. The results of the present study suggest that the chlorophyll derivatives contained in edible plants may be useful for the prevention and treatment of atherosclerosis.
authors.affiliation: a Department of Natural Medicines, Graduate School of Pharmaceutical Sciences , Kumamoto University , Kumamoto , Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Takamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Eguchi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kawabata
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Motohiro
authors.initials: M
authors.lastname: Takeya
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
mesh_terms: D050197:Atherosclerosis / Q000178:diet therapy* / Q000473:pathology; D001937:Brassica / Q000737:chemistry*; D002460:Cell Line; D002734:Chlorophyll / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D002788:Cholesterol Esters / Q000037:antagonists & inhibitors*; D005487:Foam Cells / Q000187:drug effects; D006801:Humans; D008264:Macrophages / Q000187:drug effects
chemical_list: D002788:Cholesterol Esters; D002734:Chlorophyll
keywords: Chinese cabbage; anti-atherosclerotic; chlorophyll derivatives