title: Setting limits: maintaining order in a large gene family.
abstract: Odorant receptor (OR) gene choice is a paradigmatic example of stochastic regulation in which olfactory neurons choose one OR from > 1,000 possibilities. Recent biochemical, mathematical, and in vivo findings have revealed key players, introduced new axes of control, and brought the core mechanisms of the process into sharper focus.
authors.affiliation: a Weill Cornell Medical College in Qatar; Qatar Foundation-Education City; Doha, Qatar.
authors.forename: Ishmail
authors.initials: I
authors.lastname: Abdus-Saboor
authors.forename: Alexander
authors.initials: A
authors.lastname: Fleischmann
authors.forename: Benjamin
authors.initials: B
authors.lastname: Shykind
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D005810:Multigene Family; D018035:Receptors, Odorant / Q000378:metabolism*
chemical_list: D018035:Receptors, Odorant
keywords: Eukaryotic transcription; chromatin and transcription