title: The importance of hematologic indices in the risk stratification of patients with acute decompensated systolic heart failure.
abstract: OBJECTIVE
  In patients with heart failure, a variety of hemogram parameters are known to be of prognostic significance. This study aimed to investigate which of these parameters is/are useful in predicting one-year all-cause mortality in patients with acute decompensated heart failure (ADHF).
  
  
  METHODS
  Patients who were hospitalized between September 2012-March 2013 in our hospital with systolic-ADHF with ejection fraction ≤40%, symptoms, and findings of congestion were enrolled retrospectively in the study. The study population was divided into two groups based on one-year-mortality.
  
  
  RESULTS
  119 patients with ADHF (mean-age 67±14 years; 55% male) were enrolled in the study. One-year-mortality occurred in 29% of patients. Hemoglobin levels, platelet, basophil and lymphocyte counts were significantly lower, while red-cell distribution width (RDW) was found to be significantly higher in the one-year-mortality group. Neutrophil, monocyte, and eosinophil counts were similar in the two groups. Furthermore, lower estimated glomerular-filtration-rate (eGFR) and unused angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB) were associated with mortality. Age, presence of hypertension, right-ventricular diameter, eGFR, ACE/ARB treatment, hemoglobin levels, RDW and platelet, leukocyte, lymphocyte, basophil, neutrophil, monocyte, and eosinophil-counts were found to have prognostic significance in univariate analysis. In multivariate analysis, decreased platelet, lymphocyte-counts and hemoglobin level on admission and unused ACE/ARB treatment at discharge (p<0.05) were found to be independent factors predicting one-year-mortality.
  
  
  CONCLUSIONS
  Among hematological indices; hemoglobin level, platelet and lymphocyte counts are readily available, useful and inexpensive markers for the prediction of one-year all-cause mortality in ADHF patients.
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey. mrpolatn@gmail.com.
authors.forename: Nihat
authors.initials: N
authors.lastname: Polat
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yıldız
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mehmet Zihni
authors.initials: MZ
authors.lastname: Bilik
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Aydın
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Acet
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Demir
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Işık
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Alan
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Nizamettin
authors.initials: N
authors.lastname: Toprak
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000503:physiopathology; D001772:Blood Cell Count; D005260:Female; D054143:Heart Failure, Systolic / Q000097:blood* / Q000503:physiopathology; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D006454:Hemoglobins