title: [Combination of Excessive Weight Gain and Interleukin-8: A Possible Predictor of Necrotising Enterocolitis in Neonates?].
abstract: BACKGROUND
  Weight gain before the clinical diagnosis of necrotising enterocolitis (NEC) is described as a predictive factor.
  
  
  OBJECTIVE
  Weight gain of more than 5% one day prior to clinical suspicion plus increase of plasma Iinterleukin-8 (IL-8) are predictive for NEC.
  
  
  METHODS
  48 infants with diagnosis of NEC stage II and III were enrolled in a case-control study. Oral and parenteral nutrition, diuresis and kinetics of weight and of IL-8 were documented.
  
  
  RESULTS
  31 infants with NEC-II and 17 infants with NEC-III were enrolled. Weight gain>5% occurred in 35.3% of NEC-III, in 0% of NEC-II and in 4.2% of the control group. IL-8 increased significantly [NEC-III (6 561.4 pg/mL) vs. NEC-II: (326.7 pg/mL) vs. control group (38.9 pg/mL); p<0.05]. Sensitivity of IL-8 in NEC-II was 87.10% (70.15-96.25) and in NEC-III 100.00% (80.33-100.00). Sensitivity of weight gain was 0.00% (0.00-11.32) in NEC-II and 35.29% (14.30-61.65) in NEC-III.
  
  
  CONCLUSIONS
  Weight gain>5% was found in only 35.3% of the cases with NEC-III. Combination of weight gain and IL-8 did not improve the diagnosis of NEC.
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung II: Kardiologie, Intensivmedizin, Pulmologie.
authors.forename: F
authors.initials: F
authors.lastname: Neunhoeffer
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung IV: Neonatologie.
authors.forename: H
authors.initials: H
authors.lastname: Jansen
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung IV: Neonatologie.
authors.forename: R
authors.initials: R
authors.lastname: Goelz
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung II: Kardiologie, Intensivmedizin, Pulmologie.
authors.forename: H
authors.initials: H
authors.lastname: Renk
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung IV: Neonatologie.
authors.forename: C
authors.initials: C
authors.lastname: Poets
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung V: Kinderchirurgie, Kinderurologie.
authors.forename: G
authors.initials: G
authors.lastname: Seitz
authors.affiliation: Universitätsklinik für Kinder- und Jugendmedizin Tübingen Abteilung IV: Neonatologie.
authors.forename: A
authors.initials: A
authors.lastname: Wacker
authors.affiliation: Uniklinik RWTH Aachen Klinik für Kinder- und Jugendmedizin Sektion Neonatologie.
authors.forename: T
authors.initials: T
authors.lastname: Orlikowsky
mesh_terms: D015415:Biomarkers / Q000097:blood; D020345:Enterocolitis, Necrotizing / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015430:Weight Gain
chemical_list: D015415:Biomarkers; C508606:CXCL8 protein, human; D016209:Interleukin-8