title: [Effect and mechanism of fluorofenidone on organ fibrosis].
abstract: Fibrosis can occur in different organs with high incidence rate and great danger. It still lacks effective drugs for prevention of fibrosis. Fluorofenidone is a newly developed drug with anti-fibrotic activity, which provides a new hope for treating the progressive fibrotic diseases. Recent studies have shown that fluorofenidone is a multifunctional small molecule with anti-inflammatory, antioxidative and anti-apoptotic eff ects. It can inhibit the activation and proliferation of myofibroblasts, promote the degradation of extracellular matrix and regulate the cellular signal transmission. Fluorofenidone can be applied to attenuate the progression of renal, hepatic and pulmonary fibrosis.
authors.affiliation: Department of Nephrology, Xiangya Hospital, Changsha 410008, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Zhangzhe
authors.initials: Z
authors.lastname: Peng
authors.forename: Gaoyun
authors.initials: G
authors.lastname: Hu
authors.forename: Lijian
authors.initials: L
authors.lastname: Tao
mesh_terms: D017209:Apoptosis; D005109:Extracellular Matrix; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008103:Liver Cirrhosis; D011658:Pulmonary Fibrosis; D011728:Pyridones / Q000494:pharmacology*; D015398:Signal Transduction
chemical_list: C511655:5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone; D011728:Pyridones