title: Impact of microalbuminuria on incident coronary heart disease, cardiovascular and all-cause mortality: a meta-analysis of prospective studies.
abstract: This study is to investigate the magnitude of relationship between microalbuminuria and incident coronary heart disease (CHD) and mortality in the general population by conducting a meta-analysis. A comprehensive literature search in Pubmed and Embase database was performed prior to March 2014. Only prospective studies investigating the presence of microalbuminuria and incident CHD, cardiovascular disease (CVD), and mortality and were selected. Pooled risk ratio (RR) and 95% confidence interval (CI) were calculated by the presence of microalbuminuria versus without microalbuminuria. Finally, we identified 8 prospective studies involving 114,105 individuals. Participants with microalbuminuria were associated with 69% greater risk of CVD (RR=1.69; 95% CI 1.41-2.02) and 41% greater risk of CHD (RR=1.41; 95% CI 1.17-1.69). Participants with microalbuminuria were also associated with 57% greater risk of cardiovascular mortality (RR=1.57; 95% CI 1.20-2.06) and 65% greater risk of all-cause mortality (RR=1.65; 95% CI 1.45-1.88). Microalbuminuria is an independent predictor for CHD, CVD, and all-cause mortality in the general population. Early detection of microalbuminuria in the general population is likely to identify patients at increased risk of CVD and mortality.
authors.affiliation: Department of Cardiology, Dahua Hospital Xuhui District, Shanghai 200237, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xia
authors.affiliation: Department of Interventional Radiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092, China.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Dahua Hospital Xuhui District, Shanghai 200237, China.
authors.forename: Yifu
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Dahua Hospital Xuhui District, Shanghai 200237, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
keywords: Microalbuminuria; cardiovascular disease; coronary heart disease; meta-analysis; mortality