title: Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia.
abstract: The present study established a rat model of global cerebral ischemia induced by chest compression for six minutes to dynamically observe expressional changes of three glutamate transporters in the cerebral cortex and hippocampus. After 24 hours of ischemia, expression of glutamate transporter-1 significantly decreased in the cerebral cortex and hippocampus, which was accompanied by neuronal necrosis. At 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal CA1 region and cortex, and was accompanied by apoptosis. Expression of glutamate-aspartate transporter remained unchanged at 6 hours-7 days after ischemia. These results suggested that glutamate transporter levels were altered at different periods of cerebral ischemia.
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Qinhua
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Lan
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Weiqiao
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Pin
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Liemei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Central Hospital of Fengxian District, Shanghai Neurological Research Institute of Anhui University of Science & Technology, Shanghai 201400, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
authors.forename: Yongming
authors.initials: Y
authors.lastname: Qiu
keywords: apoptosis; excitatory amino acid carrier 1; global cerebral ischemia; glutamate transporter; glutamate transporter-1; glutamateaspartate transporter; neuroprotection