title: Disrupted thalamic resting-state functional networks in schizophrenia.
abstract: The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seed-based whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the "disconnectivity model" of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.
authors.affiliation: Department of Special Education, National Taiwan Normal University Taipei, Taiwan.
authors.forename: Hsiao-Lan Sharon
authors.initials: HL
authors.lastname: Wang
authors.affiliation: Department of Physical Medicine and Rehabilitation, Shuang-Ho Hospital, Taipei Medical University Taipei, Taiwan.
authors.forename: Chi-Lun
authors.initials: CL
authors.lastname: Rau
authors.affiliation: Department of Special Education, National Taiwan Normal University Taipei, Taiwan.
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Li
authors.affiliation: Department of Physical Medicine and Rehabilitation, Shuang-Ho Hospital, Taipei Medical University Taipei, Taiwan.
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Psychology, National University of Singapore Singapore, Singapore ; Center for Life Sciences, Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore Singapore, Singapore.
authors.forename: Rongjun
authors.initials: R
authors.lastname: Yu
keywords: fMRI; functional connectivity; resting-state; schizophrenia; thalamus