title: Pregnancy outcomes in autosomal dominant polycystic kidney disease: a case-control study.
abstract: OBJECTIVE
  To determine whether autosomal dominant polycystic kidney disease (ADPKD) is associated with adverse fetal outcomes and maternal complications.
  
  
  METHODS
  We identified a cohort of 146 patients seen for pregnancy and cystic kidney disease at Mayo Clinic from 1975 to 2010. From this cohort, 54 patients met the ultrasound diagnostic criteria for ADPKD (ADPKD group), while the other 92 patients were diagnosed as "Simple Cyst" (control group). We compared the fetal and maternal outcomes of pregnancy and long-term maternal prognoses between these two groups.
  
  
  RESULTS
  Overall, the fetal complication rates were similar between the ADPKD and control groups. Rates of spontaneous abortion (15.1% versus 14%, p = 0.77) and premature birth (11.1% versus 6.8%, p = 0.44) were comparable between groups, while the rate of fetal distress (3.4% versus 0.7%, p < 0.01) was increased in the ADPKD group. The rate of preeclampsia in the patients with simple cysts (2%) was similar to that of the general population. In contrast, the pregnant ADPKD patients had higher risks for hypertension, proteinuria, edema, urinary tract infection, renal dysfunction and preeclampsia during their pregnancies.
  
  
  CONCLUSIONS
  ADPKD is associated with increased maternal complications during pregnancy, but only has a slight potential of increased rates of fetal complications.
authors.affiliation: a Department of Cardiovascular Diseases , Guang`anmen Hospital, China Academy of Chinese Medical Sciences , Beijing , People's Republic of China .
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.affiliation: b Division of Nephrology and Hypertension .
authors.forename: Diping
authors.initials: D
authors.lastname: Wang
authors.affiliation: b Division of Nephrology and Hypertension .
authors.forename: Ladan
authors.initials: L
authors.lastname: Zand
authors.affiliation: b Division of Nephrology and Hypertension .
authors.forename: Peter C
authors.initials: PC
authors.lastname: Harris
authors.affiliation: c Department of Obstetrics and Gynecology , and.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: White
authors.affiliation: b Division of Nephrology and Hypertension .
authors.forename: Vesna D
authors.initials: VD
authors.lastname: Garovic
authors.affiliation: d Division of Preventive Medicine , Mayo Clinic , Rochester , MN , USA.
authors.forename: Cindy A
authors.initials: CA
authors.lastname: Kermott
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D007231:Infant, Newborn; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000453:epidemiology*; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011507:Proteinuria / Q000453:epidemiology / Q000209:etiology; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000209:etiology; D055815:Young Adult
keywords: ADPKD; fetal outcomes; maternal complications; simple cyst disease