title: Distribution, industrial applications, and enzymatic synthesis of D-amino acids.
abstract: D-Amino acids exist widely in microbes, plants, animals, and food and can be applied in pharmaceutical, food, and cosmetics. Because of their widespread applications in industry, D-amino acids have recently received more and more attention. Enzymes including D-hydantoinase, N-acyl-D-amino acid amidohydrolase, D-amino acid amidase, D-aminopeptidase, D-peptidase, L-amino acid oxidase, D-amino acid aminotransferase, and D-amino acid dehydrogenase can be used for D-amino acids synthesis by kinetic resolution or asymmetric amination. In this review, the distribution, industrial applications, and enzymatic synthesis methods are summarized. And, among all the current enzymatic methods, D-amino acid dehydrogenase method not only produces D-amino acid by a one-step reaction but also takes environment and atom economics into consideration; therefore, it is deserved to be paid more attention.
authors.affiliation: School of Life Science, Shandong University of Technology, Zibo, 255049, China, gaoxz@sdut.edu.cn.
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Gao
authors.forename: Qinyuan
authors.initials: Q
authors.lastname: Ma
authors.forename: Hailiang
authors.initials: H
authors.lastname: Zhu
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods*; D003605:D-Amino-Acid Oxidase / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D003605:D-Amino-Acid Oxidase