title: Dynamics of behavioral disorders in transgenic mice with modeled Alzheimer's disease.
abstract: Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer's disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict situation with water deprivation, behavioral despair, and arecoline tremor. The main behavioral disorder in transgenic mice at all observation terms was memory impairment in conditioning with positive (but not negative) reinforcement. At the age of 7.5 and 10 months, transgenic mice also showed signs of nonspecific excitement and anxiety, depression-like state, and symptoms of cholinergic deficit. Our results suggest that appropriate age for behavioral tests in studies of effects of potential anti-Alzheimer drugs in transgenic V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) mice is 7.5-10 months.
authors.affiliation: Kazan State Medical University, Kazan, Russia, seminai@mail.ru.
authors.forename: I I
authors.initials: II
authors.lastname: Semina
authors.forename: A Z
authors.initials: AZ
authors.lastname: Baichurina
authors.forename: E A
authors.initials: EA
authors.lastname: Makarova
authors.forename: A V
authors.initials: AV
authors.lastname: Leushina
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Kazakevich
authors.forename: M R
authors.initials: MR
authors.lastname: Gabdrakhmanova
authors.forename: M A
authors.initials: MA
authors.lastname: Mukhamed'yarov
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000627:therapeutic use
chemical_list: D016564:Amyloid beta-Protein Precursor; D018696:Neuroprotective Agents