title: Potential Benefits of Edible Berries in the Management of Aerodigestive and Gastrointestinal Tract Cancers: Preclinical and Clinical Evidence.
abstract: Epidemiological reports as well as experimental studies have demonstrated the significant health benefits provided by regular berry consumption. Berries possess both prophylactic and therapeutic potential against several chronic illnesses, such as cardiovascular, neurodegenerative, and neoplastic diseases. Berries owe their health benefits to phytoconstituents, such as polyphenolic anthocyanins, ellagic acid, and a diverse array of phytochemicals bestowed with potent antioxidant and anti-inflammatory effects as well as the ability to engage a multitude of signaling pathways. This review highlights the principal chemical constituents present in berries and their primary molecular targets. The article presents and critically analyzes the chemopreventive and therapeutic potential of berry extracts, fractions, and bioactive components on various cancers of the gastrointestinal tract (GIT), including esophageal, stomach, intestinal, and colorectal cancers as well as cancers of the upper aerodigestive tract, such as oral cancer. The current status of clinical studies evaluating berry products in several aforementioned cancers is presented. Various emerging issues including dose-ranging and dosage forms, the role of synergy and the usage of combination therapy as well as other relevant areas essential for the development of berry phytoconstituents as mainstream chemopreventive and therapeutic agents against aerodigestive and GIT cancers are critically discussed.
authors.affiliation: a Department of Pharmaceutical Sciences , College of Pharmacy, Larkin Health Sciences Institute , Miami , Florida USA.
authors.forename: Anupam
authors.initials: A
authors.lastname: Bishayee
authors.affiliation: b Department of Pharmaceutical Sciences , College of Pharmacy, Northeast Ohio Medical University , Rootstown , Ohio USA.
authors.forename: Yennie
authors.initials: Y
authors.lastname: Haskell
authors.affiliation: b Department of Pharmaceutical Sciences , College of Pharmacy, Northeast Ohio Medical University , Rootstown , Ohio USA.
authors.forename: Chau
authors.initials: C
authors.lastname: Do
authors.affiliation: c Department of Pharmacology , Yong Loo Lin School of Medicine, National University of Singapore , Singapore.
authors.forename: Kodappully Sivaraman
authors.initials: KS
authors.lastname: Siveen
authors.affiliation: d School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Western Australia , Australia.
authors.forename: Nima
authors.initials: N
authors.lastname: Mohandas
authors.affiliation: c Department of Pharmacology , Yong Loo Lin School of Medicine, National University of Singapore , Singapore.|d School of Biomedical Sciences, Curtin Health Innovation Research Institute, Biosciences Research Precinct, Curtin University , Western Australia , Australia.
authors.forename: Gautam
authors.initials: G
authors.lastname: Sethi
authors.affiliation: e Division of Hematology and Oncology , Department of Medicine, Medical College of Wisconsin , Milwaukee , Wisconsin USA.
authors.forename: Gary D
authors.initials: GD
authors.lastname: Stoner
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000032:analysis / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000032:analysis* / Q000494:pharmacology; D002986:Clinical Trials as Topic; D004063:Digestion / Q000187:drug effects; D004195:Disease Models, Animal; D004610:Ellagic Acid / Q000032:analysis / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry*; D005770:Gastrointestinal Neoplasms / Q000517:prevention & control*; D006801:Humans; D064209:Phytochemicals / Q000032:analysis / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis* / Q000494:pharmacology; D059808:Polyphenols / Q000032:analysis / Q000494:pharmacology
chemical_list: D000872:Anthocyanins; D016588:Anticarcinogenic Agents; D064209:Phytochemicals; D010936:Plant Extracts; D059808:Polyphenols; D004610:Ellagic Acid
keywords: Berry; aerodigestive and gastrointestinal tract; cancer; chemoprevention; treatment