title: The relationship between structure and function as measured by OCT and Octopus perimetry.
abstract: OBJECTIVE
  To determine the structure-function relationship between equivalent visual field areas obtained with the Octopus perimeter (OP), and the peripapillary retinal nerve fibre layer (RNFL) thickness measured with spectral-domain optical coherence tomography (OCT) in healthy individuals and patients with glaucomatous optic neuropathy.
  
  
  METHODS
  Eighty-eight normal subjects and 150 patients with open-angle glaucoma were prospectively recruited. Eligible participants for the glaucoma group were required to have elevated intraocular pressure and glaucomatous optic nerve head morphology. All participants underwent reliable automated perimetry with OP, and optic nerve head imaging with the Cirrus OCT. Principal component analysis of the mean threshold values for the visual field test points were performed independently for each hemifield. Pearson correlations were calculated between visual field regions and RNFL thickness sectors.
  
  
  RESULTS
  Mild to moderate correlations were observed between the visual field regions and the peripapillary RNFL thicknesses. Each visual field region was significantly correlated with more than one RNFL sector, and vice versa. The strongest correlation was observed between the RNFL thickness at 5 and 7 clock-hour positions and the superonasal region of OP (r=0.63).
  
  
  CONCLUSIONS
  Retinal sensitivity evaluated with OP correlated moderately well with the RNFL thickness measured by OCT. There was an overlap of the visual field regions within the optic disc.
authors.affiliation: Hospital General Universitario Gregorio Marañón, Instituto Oftálmico de Madrid, Madrid, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Monsalve
authors.affiliation: Department of Ophthalmology, Miguel Servet University Hospital, Aragon Health Sciences Institute, Zaragoza, Spain Department of Ophthalmology, University of Zaragoza, Zaragoza, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Khawaja
authors.affiliation: Department of Ophthalmology, Miguel Servet University Hospital, Aragon Health Sciences Institute, Zaragoza, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Calvo
authors.affiliation: Department of Ophthalmology, Miguel Servet University Hospital, Aragon Health Sciences Institute, Zaragoza, Spain.
authors.forename: Mirian
authors.initials: M
authors.lastname: Ara
authors.affiliation: G.B. Bietti Foundation-IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Fogagnolo
authors.affiliation: University of Genoa, Genoa, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Iester
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005163:Factor Analysis, Statistical; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000503:physiopathology*; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology
keywords: Diagnostic tests/Investigation; Glaucoma; Imaging; Psychophysics