title: Regulating chemicals: law, science, and the unbearable burdens of regulation.
abstract: The challenges of regulating industrial chemicals remain unresolved in the United States. The Toxic Substances Control Act (TSCA) of 1976 was the first legislation to extend coverage to the regulation of industrial chemicals, both existing and newly registered. However, decisions related to both law and science that were made in passing this law inevitably rendered it ineffectual. Attempts to fix these shortcomings have not been successful. In light of the European Union's passage of innovative principles and requirements for chemical regulation, it is no longer possible to deny the opportunity and need for reform in US law and practice.
authors.affiliation: Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205; email: esilber2@jhu.edu , dmandri1@jhu.edu.
authors.forename: Ellen K
authors.initials: EK
authors.lastname: Silbergeld
authors.forename: Daniele
authors.initials: D
authors.lastname: Mandrioli
authors.forename: Carl F
authors.initials: CF
authors.lastname: Cranor
mesh_terms: D004787:Environmental Pollution / Q000331:legislation & jurisprudence / Q000517:prevention & control; D033161:Government Regulation / Q000266:history; D015386:Hazardous Substances / Q000266:history / Q000633:toxicity*; D049673:History, 20th Century; D006801:Humans; D007878:Legislation as Topic / Q000266:history; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D015386:Hazardous Substances
keywords: REACH; TTIP; Toxic Substances Control Act; burden of proof; toxicology