title: [Thought and method of reproductive toxicity research in traditional Chinese medicine].
abstract: Reproductive toxicity research takes an important place in traditional Chinese medicine pre-clinical safety evaluation. Modern reproductive toxicity experiment includes drug-related miscarriage, fetal death, teratism, and adverse effects on fertility, genital system, embryonic development and fetus, which is different from contraindicated in pregnancy in traditional Chinese medicine theory. Now the three-phases reproductive toxicity study is the method mainly applied in traditional Chinese medicine reproductive toxicity evaluation. Besides that, alternative methods of whole embryos culture and embryonic stem cell test are also used in traditional Chinese medicine embryo toxicity evaluation. This article reviews research progress and pre-clinical evaluation on reproductive toxicity of traditional Chinese medicine.
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Han
authors.forename: Yi
authors.initials: Y
authors.lastname: Yan
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Liang
authors.forename: Yu-shi
authors.initials: YS
authors.lastname: Zhang
authors.forename: Chun-ying
authors.initials: CY
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yu-ting
authors.initials: YT
authors.lastname: Lu
authors.forename: Hong-yu
authors.initials: HY
authors.lastname: Cui
authors.forename: Gui-qin
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D047108:Embryonic Development / Q000187:drug effects; D053595:Embryonic Stem Cells / Q000187:drug effects; D005260:Female; D006801:Humans; D008516:Medicine, Chinese Traditional; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D018675:Toxicity Tests
chemical_list: D004365:Drugs, Chinese Herbal