title: Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Newton
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
authors.forename: Santiago
authors.initials: S
authors.lastname: Lima
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Maceyka
authors.affiliation: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine and the Massey Cancer Center, Richmond, Virginia 23298, USA. Electronic address: sspiegel@vcu.edu.
authors.forename: Sarah
authors.initials: S
authors.lastname: Spiegel
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002518:Ceramides / Q000502:physiology; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D049312:Receptors, Lysophospholipid / Q000378:metabolism; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology; D000099157:Sphingosine Kinase
chemical_list: D000970:Antineoplastic Agents; D002518:Ceramides; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D049312:Receptors, Lysophospholipid; D013110:Sphingosine; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate
keywords: Ceramide; Sphingolipid rheostat; Sphingosine kinase; Sphingosine-1-phosphate