title: Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin.
abstract: BACKGROUND
  Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal and obese patients is a pending issue.
  
  
  OBJECTIVE
  The aim of this study was to investigate GH after OG in relation with adiposity, insulin secretion and action, and ghrelin secretion in obese and healthy women, to further elucidate the mechanism of GH secretion after OG and the altered GH secretion in obesity.
  
  
  METHODS
  We included 64 healthy and obese women. After an overnight fast, 75 g of OG were administered; GH, glucose, insulin and ghrelin were obtained during 300 minutes. Insulin secretion and action indices and the area under the curve (AUC) were calculated for GH, glucose, insulin and ghrelin. Univariate and multivariate linear regression analyses were employed.
  
  
  RESULTS
  The AUC of GH (μg/L•min) was lower in obese (249.8±41.8) than in healthy women (490.4±74.6), P=0.001. The AUC of total ghrelin (pg/mL•min) was lower in obese (240995.5±11094.2) than in healthy women (340797.5±37757.5), P=0.042. There were significant correlations between GH secretion and the different adiposity, insulin secretion and action, and ghrelin secretion indices. After multivariate analysis only ghrelin AUC remained a significant predictor for fasting and peak GH.
authors.affiliation: Department of Medicine, Faculty of Health Sciences, University of A Coruña, A Coruña, Spain; Instituto de Investigación Biomedica (INIBIC), University Hospital A Coruña, A Coruña, Spain.
authors.forename: Lara
authors.initials: L
authors.lastname: Pena-Bello
authors.affiliation: Clinical Epidemiology and Biostatistics Unit, University Hospital A Coruña, A Coruña, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Pertega-Diaz
authors.affiliation: Department of Endocrinology, University Hospital A Coruña, A Coruña, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Outeiriño-Blanco
authors.affiliation: Instituto de Investigación Biomedica (INIBIC), University Hospital A Coruña, A Coruña, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Garcia-Buela
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain.
authors.forename: Sulay
authors.initials: S
authors.lastname: Tovar
authors.affiliation: Department of Medicine, Faculty of Health Sciences, University of A Coruña, A Coruña, Spain; Instituto de Investigación Biomedica (INIBIC), University Hospital A Coruña, A Coruña, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Sangiao-Alvarellos
authors.affiliation: Department of Physiology (CIMUS), School of Medicine-Instituto de Investigaciones Sanitarias (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Dieguez
authors.affiliation: Department of Medicine, Faculty of Health Sciences, University of A Coruña, A Coruña, Spain; Instituto de Investigación Biomedica (INIBIC), University Hospital A Coruña, A Coruña, Spain; Department of Endocrinology, University Hospital A Coruña, A Coruña, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Cordido
mesh_terms: D050154:Adiposity; D000328:Adult; D005260:Female; D054439:Ghrelin / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood*
chemical_list: D054439:Ghrelin; D019382:Human Growth Hormone; D005947:Glucose