title: Increase in maternal death-related venous thromboembolism during pregnancy in Japan (2010-2013).
abstract: BACKGROUND
  The aim of the present work was to understand the current circumstances of maternal-death-related venous thromboembolism (MD-VTE) in Japan. We retrospectively investigated the characteristics of cases of MD-VTE, and compared past and present rates of occurrence.
  
  
  RESULTS
  We examined the Japanese data for MD-VTE in 2010-2013, and compared it with that from 1991-1992. MD-VTE occurred in 17 women in 1991-1992, and in 13 women in 2010-2013. The maternal mortality ratio of MD-VTE was 0.7 per 100,000 in 1991-1992 and 0.4 per 100,000 in 2010-2013. Both the maternal mortality ratio and rate of MD-VTE in 2010-2013 deceased significantly compared with 1991-1992 (P<0.05). However, the number of cases of MD-VTE during pregnancy was 6 among 13 women (41%) in 2010-2013, but 1 in 17 women (6%) in 1991-1992, showing an increase (P<0.05). In the present study, cesarean delivery was more frequently associated with MD-VTE.
  
  
  CONCLUSIONS
  MD-VTE overall has decreased within the past 20 years in Japan. But, MD-VTE during pregnancy in 2010-2013 increased relative to 1991-1992. Future guidelines for prevention of VTE may need to extend beyond the perioperative period to decrease the incidence of MD-VTE.
authors.affiliation: Department of Obstetrics and Gynecology, Mie University School of Medicine.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shinji
authors.initials: S
authors.lastname: Katsuragi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Osato
authors.forename: Junichi
authors.initials: J
authors.lastname: Hasegawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Nakata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Murakoshi
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshimatsu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Sekizawa
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
authors.forename: Isamu
authors.initials: I
authors.lastname: Ishiwata
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects; D002585:Cesarean Section; D003681:Dehydration / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007889:Leiomyoma / Q000453:epidemiology; D008423:Maternal Age; D008428:Maternal Mortality / Q000639:trends; D011183:Postoperative Complications / Q000401:mortality; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology / Q000401:mortality*; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology; D011644:Puerperal Disorders / Q000401:mortality; D011655:Pulmonary Embolism / Q000401:mortality*; D012189:Retrospective Studies; D053828:Stockings, Compression / Q000706:statistics & numerical data; D014594:Uterine Neoplasms / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000401:mortality*
chemical_list: D005343:Fibrinolytic Agents