title: Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles.
abstract: We describe for the first time a therapeutic strategy to target stem-like cancer cells via STAT-3 modulation using a nanomedicine approach. Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. Niclocelles were found to selectively reduce the CD44+ stem cell population in C32 cells via STAT-3 modulation.
authors.affiliation: Department of Bioengineering, Materials Science and Engineering and Beckman Institute, University of Illinois at Urbana-Champaign and Carle Cancer Center, 502 N. Busey, Urbana, IL 61801, USA. dipanjan@illinois.edu.
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Misra
authors.forename: Tor W
authors.initials: TW
authors.lastname: Jensen
authors.forename: Dipanjan
authors.initials: D
authors.lastname: Pan
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D061986:MCF-7 Cells; D008823:Micelles; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009534:Niclosamide / Q000737:chemistry* / Q000633:toxicity; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D018960:Hyaluronan Receptors; D008823:Micelles; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D009534:Niclosamide