title: Dynamic contrast-enhanced magnetic resonance imaging in Head and Neck Cancer: differentiation of new H&N cancer, recurrent disease, and benign post-treatment changes.
abstract: OBJECTIVE
  To determine if dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) parameters such as permeability surface area (PS) and blood volume (BV) allow differentiating between new head and neck (HN) cancer, recurrent HN cancer, and post-treatment benign changes.
  
  
  METHODS
  A total of 35 patients with newly diagnosed, recurrent, and benign post-treatment benign changes underwent DCE-MRI. PS and BV were calculated.
  
  
  RESULTS
  PS values of the lesion were 2.3×10(4)±5.8×10(4) for the newly diagnosed cancer group, 3.3×10(4)±1.7×10(4) for the recurrent cancer group, and 4.8×10(4)±8.1×10(4) for the post-treatment benign change group (P=.031).
  
  
  CONCLUSIONS
  Post-treatment benign changes in the HN region had significantly high permeability property than newly diagnosed or previously treated recurrent tumor.
authors.affiliation: Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195.
authors.forename: Mitsutomi
authors.initials: M
authors.lastname: Ishiyama
authors.affiliation: Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195.
authors.forename: Todd
authors.initials: T
authors.lastname: Richards
authors.affiliation: Department of Radiation Oncology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195.
authors.forename: Upendra
authors.initials: U
authors.lastname: Parvathaneni
authors.affiliation: Department of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195. Electronic address: anzai@uw.edu.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Anzai
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D003287:Contrast Media
keywords: Dynamic contrast-enhanced MRI; Head and neck cancer; Permeability surface area product