title: Na+ channel function, regulation, structure, trafficking and sequestration.
abstract: This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na(+) channel function and regulation, Na(+) channel structure and function, and Na(+) channel trafficking, sequestration and complexing.
authors.affiliation: Department of Pharmacology, University of California, Davis, USA; Department of Biomedical Engineering, University of California, Davis, USA; Department of Internal Medicine/Cardiology, University of California, Davis, USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Chen-Izu
authors.forename: Robin M
authors.initials: RM
authors.lastname: Shaw
authors.forename: Geoffrey S
authors.initials: GS
authors.lastname: Pitt
authors.forename: Vladimir
authors.initials: V
authors.lastname: Yarov-Yarovoy
authors.forename: Jon T
authors.initials: JT
authors.lastname: Sack
authors.forename: Hugues
authors.initials: H
authors.lastname: Abriel
authors.forename: Richard W
authors.initials: RW
authors.lastname: Aldrich
authors.forename: Luiz
authors.initials: L
authors.lastname: Belardinelli
authors.forename: Mark B
authors.initials: MB
authors.lastname: Cannell
authors.forename: William A
authors.initials: WA
authors.lastname: Catterall
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Chazin
authors.forename: Nipavan
authors.initials: N
authors.lastname: Chiamvimonvat
authors.forename: Isabelle
authors.initials: I
authors.lastname: Deschenes
authors.forename: Eleonora
authors.initials: E
authors.lastname: Grandi
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hund
authors.forename: Leighton T
authors.initials: LT
authors.lastname: Izu
authors.forename: Lars S
authors.initials: LS
authors.lastname: Maier
authors.forename: Victor A
authors.initials: VA
authors.lastname: Maltsev
authors.forename: Celine
authors.initials: C
authors.lastname: Marionneau
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mohler
authors.forename: Sridharan
authors.initials: S
authors.lastname: Rajamani
authors.forename: Randall L
authors.initials: RL
authors.lastname: Rasmusson
authors.forename: Eric A
authors.initials: EA
authors.lastname: Sobie
authors.forename: Colleen E
authors.initials: CE
authors.lastname: Clancy
authors.forename: Donald M
authors.initials: DM
authors.lastname: Bers
mesh_terms: D000200:Action Potentials; D000595:Amino Acid Sequence; D000818:Animals; D003226:Congresses as Topic; D006801:Humans; D008969:Molecular Sequence Data; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D021381:Protein Transport; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000737:chemistry / Q000378:metabolism*
chemical_list: D026941:Sodium Channel Blockers; D015222:Sodium Channels