title: Assessment of the relationship between ACE I/D gene polymorphism and renal allograft survival.
abstract: OBJECTIVE
  The relationship between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and renal allograft survival after renal transplantation from the published reports are still debatable. This study was performed to evaluate the relationship between the ACE I/D gene polymorphism and renal allograft survival after renal transplantation using meta-analysis.
  
  
  METHODS
  Eligible studies were identified from PubMed and Cochrane Library on 1 November 2014, and eligible studies were recruited and synthesized using a meta-analysis methodology.
  
  
  RESULTS
  Twelve investigations were included in this meta-analysis for the assessment of the relationship between the ACE I/D gene polymorphism and renal allograft survival. In this meta-analysis, the ACE I/D gene polymorphism was not associated with renal allograft survival after renal transplantation for overall populations, Caucasians, Brazilians and Africans. Interestingly, the ACE D allele and DD genotype were associated with renal allograft survival after renal transplantation in the Asian population.
  
  
  CONCLUSIONS
  ACE D allele and DD genotype were associated with renal allograft survival after renal transplantation in the Asian population. However, more studies should be performed to confirm this association.
authors.affiliation: Department of Emergency, the First Affiliated Hospital, Sun Yatsen University, China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Military Command, Southern Medical University, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Critical Medicine, the First Affiliated Hospital, Sun Yatsen University, China.
authors.forename: Xue-Xia
authors.initials: XX
authors.lastname: Chen
authors.affiliation: Department of Critical Medicine, the First Affiliated Hospital, Sun Yatsen University, China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Xian
authors.affiliation: Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Military Command, Southern Medical University, China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Tu
authors.affiliation: Department of Nephrology, Huadu District People's Hospital, Southern Medical University, China hongyli@yeah.net.
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Li
mesh_terms: D064591:Allografts / Q000276:immunology*; D044466:Asian People / Q000235:genetics; D056726:Genetic Association Studies; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016030:Kidney Transplantation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme (ACE); gene polymorphism; insertion/deletion (I/D); meta-analysis; renal allograft survival; renal transplantation