title: Archaeosomes: an excellent carrier for drug and cell delivery.
abstract: Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Gurmeet
authors.initials: G
authors.lastname: Kaur
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D001105:Archaea / Q000737:chemistry*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D018014:Gene Transfer Techniques; D005995:Glyceryl Ethers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000276:Adjuvants, Immunologic; D004337:Drug Carriers; D005995:Glyceryl Ethers; D008081:Liposomes; D010455:Peptides; C094417:archaeol lipid; C094418:caldarchaeol
keywords: Archaeobacteria; archaeosomes; cell delivery; drug delivery; gene delivery