title: DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster.
abstract: Disconnected Interacting Protein 1 (DIP1) is a dsRNA-binding protein that participates in a wide range of cellular processes. Whether DIP1 is involved in innate immunity remains unclear. Here, DIP1 was found to play an antiviral role in S2 cells. Its antiviral action is specific for DCV infection and not for DXV infection. dip1 mutant flies are hypersensitive to DCV infection. The increased mortality in dip1 mutant flies is associated with the accumulation of DCV positive-stranded RNAs in vivo. This study demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo.
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Xinlei
authors.initials: X
authors.lastname: Gao
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Shuishui
authors.initials: S
authors.lastname: Qi
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Chang
authors.affiliation: School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China; The CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: wuqf@ustc.edu.cn.
authors.forename: Qingfa
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D029721:Drosophila Proteins / Q000502:physiology*; D004331:Drosophila melanogaster; D007304:Insect Viruses / Q000472:pathogenicity*; D014157:Transcription Factors / Q000502:physiology*; D014777:Virus Diseases / Q000503:physiopathology / Q000517:prevention & control
chemical_list: C410062:DISCO Interacting Protein 1, Drosophila; D017931:DNA Primers; D029721:Drosophila Proteins; D014157:Transcription Factors
keywords: Antiviral gene; DCV; DIP1; dsRNA binding domain