title: Effect of gentiopicroside on experimental acute pancreatitis induced by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats.
abstract: Gentiopicroside (otherwise known as Gentiopicrin), one of the main active ingredients from the traditional Chinese herb medicine Gentiana manshurica Kitag, presents the effect of attenuating acute pancreatitis in rats. The experimental acute pancreatitis was made by retrograde injection of sodium taurocholate into the biliopancreatic duct in rats. Gentiopicroside was given orally and it markedly reduced the pancreatitis-evoked increase of serum amylase and lipase activity, decreased the pancreas mass/body mass index, tissue water content, TNF-α and IL-1β concentrations, and attenuated the histopathological changes and NF-κB p65 protein expression in pancreatic tissue. The results indicate that the function of gentiopicroside on acute pancreatitis may be related to inhibiting the release of inflammatory mediators and NF-κB p65 protein expression.
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lv
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China. Electronic address: gwl22@163.com.
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Gu
authors.affiliation: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China.
authors.forename: Chang-Xun
authors.initials: CX
authors.lastname: Chen
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D004195:Disease Models, Animal; D053583:Interleukin-1beta / Q000378:metabolism; D057888:Iridoid Glucosides / Q000494:pharmacology*; D008049:Lipase / Q000097:blood; D008297:Male; D010179:Pancreas / Q000187:drug effects*; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013656:Taurocholic Acid / Q000009:adverse effects; D051996:Transcription Factor RelA / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D057888:Iridoid Glucosides; C498145:Rela protein, rat; D051996:Transcription Factor RelA; D014409:Tumor Necrosis Factor-alpha; C012997:gentiopicroside; D013656:Taurocholic Acid; D008049:Lipase; D000681:Amylases
keywords: Acute pancreatitis; Gentiopicroside; Gentiopicroside (PubChem CID 88708); Inflammation; NF-κB p65; Sodium taurocholate; Sodium taurocholate (PubChem CID: 23666345)