title: Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells.
abstract: In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.
authors.affiliation: a Department of Nutritional Science and Food Management , Ewha Womans University , Seoul , Korea.
authors.forename: Mak-Soon
authors.initials: MS
authors.lastname: Lee
authors.forename: Chong-Tai
authors.initials: CT
authors.lastname: Kim
authors.forename: In-Hwan
authors.initials: IH
authors.lastname: Kim
authors.forename: Yangha
authors.initials: Y
authors.lastname: Kim
mesh_terms: D002784:Cholesterol / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D056945:Hep G2 Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D064429:Fatty Acid Synthases
keywords: 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase; HepG2 cells; Korean red ginseng water extract (KRGE); fatty acid synthase (FAS); hepatic lipid accumulation