title: Concurrent primary peritoneal low-grade serous carcinoma and endometrial high-grade serous carcinoma.
abstract: A 64-yr-old postmenopausal woman with high-grade squamous intraepithelial lesion and atypical glandular cell of undetermined significance on her Pap test was found to have endometrial serous carcinoma (high grade) involving a polyp in a subsequent endometrial biopsy. She underwent hysterectomy and bilateral salpingo-oophorectomy with multiple biopsies of the peritoneum. Microscopic examination of the entirely submitted uterus showed no residual serous carcinoma. Multiple foci of low-grade serous tumor with extensive calcifications and psammoma bodies were identified on the surfaces of the left fallopian tube, ovaries, and biopsies of the peritoneum, consistent with peritoneal primary low-grade serous carcinoma. To our knowledge, this is the first reported case of low-grade serous carcinoma of the peritoneum with a concurrent (high-grade) serous carcinoma of the endometrium arising from an endometrial polyp.
authors.affiliation: Department of Pathology (M.G.L, N.Z.-K.), Baylor College of Medicine, One Baylor Plaza Department of Pathology (M.T.D.), MD Anderson Cancer Center, Houston, Texas.
authors.forename: Megan G
authors.initials: MG
authors.lastname: Lockyer
authors.forename: Michael T
authors.initials: MT
authors.lastname: Deavers
authors.forename: Neda
authors.initials: N
authors.lastname: Zarrin-Khameh
mesh_terms: D018284:Cystadenocarcinoma, Serous / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005185:Fallopian Tube Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D060787:Neoplasm Grading; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000473:pathology*; D011127:Polyps / Q000473:pathology*