title: In Vitro Activity of Tigecycline and Colistin against clinical isolates of Acinetobacter baumannii in Hospitals in Tehran and Bandar-Abbas, Iran.
abstract: BACKGROUND
  The Acinetobacter species, particularly A. baumannii, has emerged as one of the main causes of nosocomial infections in recent years. The high prevalence of drug resistance in A. baumannii limits the therapeutic options for treating infections caused by these bacteria. The objective of this study was to determine the in vitro activity of Tigecycline and Colistin against clinical isolates of A. baumannii in Tehran and Bandar Abbas, Iran.
  
  
  METHODS
  This study was conducted from March 2009 to November 2010 at three hospitals in Tehran and Bandar Abbas, Iran, using 165 Acinetobacter species isolated from clinical specimens. All isolates were subjected to PCR to detect bla OXA-51-like genes that are unique to Acinetobacter baumannii. Isolates that gave a band for the bla OXA-51-like genes were identified as A. baumannii. Anti-microbial susceptibility tests were performed for Tigecycline, Colistin, and other antibiotics.
  
  
  RESULTS
  Sensitivity rates to Colistin and Polymyxin-B were 100%. Resistance rates for Tigecycline were 4.2% in Tehran and 8.8% in Bandar-Abbas according to Jones criteria, whereas, according to U.S. FDA criteria, the resistance rates were 20.8% and 17.6%, respectively.
  
  
  CONCLUSIONS
  New alternative drugs are needed for the treatment of drug resistant A. baumannii. Although Colistin appears to be a good choice, adverse reactions have limited its usage. Tigecycline is effective against A. baumannii isolates, and it shows promise for solving the problem.
authors.affiliation: Ph.D. in Medical Bacteriology, Associate Professor, Department of Bacteriology, Faculty of Medical sciences, University of Tarbiat Modares, Tehran, Iran.
authors.forename: Shahin Najar
authors.initials: SN
authors.lastname: Peerayeh
authors.affiliation: Ph.D. in Medical Bacteriology, Assistant Professor, Infectious & Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Karmostaji
authors.affiliation: M.Sc. of Bacteriology, Sirjan University of Medical Sciences, Sirjan, Iran.
authors.forename: Soraya Sharifi
authors.initials: SS
authors.lastname: Sarasiabi
authors.affiliation: Ph.D. in Medical Bacteriology, Associate Professor, Infectious & Tropical Diseases Research Center, Hormozgan university of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Javadpour
authors.affiliation: M.D. and Infectious Disease Specialist, Associate Professor, Infectious & Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Parivash
authors.initials: P
authors.lastname: Davoodian
authors.affiliation: M.Sc. of Bacteriology, Faculty of Medicine, Infectious & Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Moradi
keywords: Acinetobacter baumannii; Polymyxin-B, Colistin; Tigecycline