title: Distinctive features of NREM parasomnia behaviors in parkinson's disease and multiple system atrophy.
abstract: OBJECTIVE
  To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson's Disease (PD) and Multiple System Atrophy (MSA).
  
  
  METHODS
  From 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.
  
  
  RESULTS
  19 NPBs were identified, 12 of which consisting of 'elementary' NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).
  
  
  CONCLUSIONS
  Many PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.
  
  
  CONCLUSIONS
  This study help bring to attention an overlooked phenomenon in neurodegenerative diseases.
authors.affiliation: Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France; UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France; Sleep and Epilepsy center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.
authors.forename: Pietro-Luca
authors.initials: PL
authors.lastname: Ratti
authors.affiliation: Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Sierra-Peña
authors.affiliation: Sleep Medicine and Epilepsy unit, C. Mondino National Neurological Institute, Pavia, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Manni
authors.affiliation: UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France; Department of Neurology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Simonetta-Moreau
authors.affiliation: Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France; Joseph Fourier University, Grenoble, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Bastin
authors.affiliation: Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France.
authors.forename: Harrison
authors.initials: H
authors.lastname: Mace
authors.affiliation: Department of Clinical Pharmacology, Toulouse University Hospital and Paul Sabatier University, Toulouse, France; UMR 825 Brain imaging and neurological dysfunctions, INSERM, Toulouse, France; Reference Centre for Multiple System Atrophy, Toulouse University Hospital, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Rascol
authors.affiliation: Brain Function & Neuromodulation, Grenoble Institute of Neuroscience, Grenoble, France; Joseph Fourier University, Grenoble, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: David
mesh_terms: D000368:Aged; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D017286:Polysomnography; D020923:REM Sleep Parasomnias / Q000503:physiopathology*