title: Monocarboxylation and intramolecular coupling of butenylated arenes via palladium-catalyzed C-H activation process.
abstract: A novel and practical reaction for the direct intramolecular oxidative coupling of butenylated arenes is reported. With the catalysis of Pd(OAc)2, reactions of various butenylated arenes and carboxylic acids with Selectfluor reagent in CH3CN solution afforded the corresponding monocarboxylation/cyclization products in good yields under mild conditions. This research demonstrated an economic method with the synthesis of 2-tetralyl carboxylic esters, a valuable class of bioactive compounds.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Ze-Hai
authors.initials: ZH
authors.lastname: Lu
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Hu
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Li
authors.affiliation: ‡Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Xian-Jin
authors.initials: XJ
authors.lastname: Yang