title: [Epidemiological and basic research activity targeting polyomaviruses].
abstract: Recently, the family Polyomaviridae was classified as 3 genera, such as Orthopolyomavirus, Wukipolyomavirus which contain mammalian polyomaviruses and Avipolyomavirus which only contain avian polyomaviruses. We have recently isolated novel polyomaviruses, including Mastomys Polyoamvirus (MasPyV) and Vervet monkey Polyoamvirus-1 (VmPyV-1) by epidemiological activities and examined functions of their encoding proteins. In addition, we have been investigating the mechanisms of replication of human polyomavirus, JC polyomavirus (JCPyV). We recently obtained the results of function of JCVPyV-encoding proteins, including early protein (Large T antigen) and late proteins (VP1 and Agno). In this review, we summarized the data of our basic research activities.
authors.affiliation: Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Sawa
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tadaki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Orba
mesh_terms: D000818:Animals; D000957:Antigens, Viral, Tumor / Q000502:physiology; D002110:Caffeine / Q000494:pharmacology; D002453:Cell Cycle / Q000235:genetics; D004261:DNA Replication; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D011120:Polyomavirus / Q000145:classification / Q000235:genetics / Q000502:physiology; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000821:virology; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000821:virology; D014771:Virion / Q000502:physiology; D014779:Virus Replication / Q000235:genetics
chemical_list: D000957:Antigens, Viral, Tumor; D004279:DNA, Viral; D002110:Caffeine