title: Brain morphometry and electrophysiological recordings in relation to illness duration in schizophrenia.
abstract: Schizophrenia has been recently increasingly linked with a number of structural brain morphological changes which can be associated with functional deficiencies. The aim of this study is to relate electrophysiological changes with structural changes of Heschl's gyrus (HG) volume in schizophrenia. Fifteen schizophrenia patients were compared with control group by magnetic resonance imaging (MRI) volumetry and auditory evoked potentials. A significantly lower bilateral HG volumes and a significantly lower global field power value of the N1P2 component were detected in the schizophrenia group. The auditory evoked potentials have been used as a functional correlate that displayed a significant amplitude reduction that matched the reduction in the HG volume with the chronicity of the disease. This trend may be utilized as a vehicle to assess follow-up of the disorder by means of MRI and electrophysiology.
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Radiology, Izmir, Turkey; Dokuz Eylul University, Faculty of Medicine, Department of Biophysics, Izmir, Turkey. Electronic address: nurikarabay@gmail.com.
authors.forename: Nuri
authors.initials: N
authors.lastname: Karabay
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Biophysics, Izmir, Turkey. Electronic address: adile.oniz@gmail.com.
authors.forename: Adile
authors.initials: A
authors.lastname: Öniz
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Biophysics, Izmir, Turkey. Electronic address: serhat.taslica@gmail.com.
authors.forename: Serhat
authors.initials: S
authors.lastname: Taşlıca
authors.affiliation: Dokuz Eylul University, Faculty of Medicine Department of Psychiatry, Izmir, Turkey. Electronic address: koksal.alptekin@deu.edu.tr.
authors.forename: Köksal
authors.initials: K
authors.lastname: Alptekin
authors.affiliation: Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; NORMENT Center of Excellence, University of Bergen, Norway. Electronic address: Hugdahl@psybp.uib.no.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hugdahl
authors.affiliation: Dokuz Eylul University, Faculty of Medicine, Department of Biophysics, Izmir, Turkey. Electronic address: murat.ozgoren@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Özgören
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D018450:Disease Progression; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D055815:Young Adult
keywords: Auditory evoked potentials; Global field power; Heschl’s gyrus; Magnetic resonance volumetry