title: Successful bone marrow transplantation of an adolescent young adult female with pregnancy-associated aplastic anemia.
abstract: Cases of pregnancy-associated severe aplastic anemia (SAA) have been reported in the literature with historically high rates of mortality. We report the case of a 17-year-old female diagnosed with SAA at 26 weeks of gestation. She experienced intrauterine fetal demise and did not achieve hematologic remission after delivery. She received a histocompatible sibling donor bone marrow transplant 7 weeks after her diagnosis and remains in remission, at 1-year posttransplant. We review available literature and suggest that when a histocompatible sibling donor is available, bone marrow transplantation should be considered as a first-line therapy for patients with pregnancy-associated SAA.
authors.affiliation: *Blood and Marrow Transplantation, Children's Hospital Los Angeles †Pediatric Hematology Oncology, Department of Pediatrics, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA ‡Pediatric Blood and Marrow Transplantation, Department of Pediatrics, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: Hisham
authors.initials: H
authors.lastname: Abdel-Azim
authors.forename: Baro
authors.initials: B
authors.lastname: Jovi-Usude
authors.forename: Chelsea
authors.initials: C
authors.lastname: Balian
authors.forename: Ami J
authors.initials: AJ
authors.lastname: Shah
authors.forename: Shinyi
authors.initials: S
authors.lastname: Tang
authors.forename: Arpan
authors.initials: A
authors.lastname: Sinha
authors.forename: Neena
authors.initials: N
authors.lastname: Kapoor
authors.forename: Kris M
authors.initials: KM
authors.lastname: Mahadeo
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*
chemical_list: D007166:Immunosuppressive Agents