title: Effect of the Mediterranean diet on the lipid-lipoprotein profile: is it influenced by the family history of dyslipidemia?
abstract: OBJECTIVE
  To examine whether a family history of dyslipidemia influences the lipid-lipoprotein response to the Mediterranean diet (MedDiet).
  
  
  METHODS
  We recruited 36 individuals with a positive family history of dyslipidemia (i.e. having at least one first-degree relative with a diagnosis of dyslipidemia) and 28 individuals with a negative family history of dyslipidemia, aged between 24 and 53 years, who had slightly elevated low-density lipoprotein cholesterol (LDL-C) concentrations (3.4-4.9 mmol/l) or a total cholesterol to high-density lipoprotein cholesterol (HDL-C) ratio≥5.0. Variables related to the lipid-lipoprotein profile were measured before and after a 4-week isocaloric MedDiet during which all foods and drinks were provided to participants.
  
  
  RESULTS
  A group by time interaction was noted for plasma total cholesterol concentrations (p=0.03), subjects with a negative family history of dyslipidemia having greater decreases than those with a positive family history of dyslipidemia (-11.3 vs. -5.1%, respectively). Decreases in LDL-C, HDL-C, total cholesterol to HDL-C ratio, LDL-C to HDL-C ratio, apo B, apo A-1, apo A-2 and apo B to apo A-1 ratio were noted, with no difference between groups (p for group by time interaction≥0.11).
  
  
  CONCLUSIONS
  Results highlight that inherited susceptibilities to dyslipidemia may explain at least in part the heterogeneity in the cholesterol-lowering effects of the MedDiet.
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, Qué., Canada.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bédard
authors.forename: Louise
authors.initials: L
authors.lastname: Corneau
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dodin
authors.forename: Simone
authors.initials: S
authors.lastname: Lemieux
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D038441:Diet, Mediterranean; D050171:Dyslipidemias / Q000097:blood / Q000178:diet therapy* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D054647:Nutrigenomics; D055815:Young Adult
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol