title: Synthesis and evaluation of single-wall carbon nanotube-paclitaxel-folic acid conjugate as an anti-cancer targeting agent.
abstract: Single-wall carbon nanotubes (SWCNT) represent a novel nanomaterial applied in various nanotechnology fields because of their surface chemistry properties and high drug cargo capacity. In this study, SWCNT are pre-functionalized covalently with paclitaxel (PTX) - an anticancer drug, and folic acid (FA), as a targeting agent for many tumors. The samples are investigated and evaluated by different analyses such as Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), thermal gravimetric analysis (TGA), absorption spectroscopic measurements (UV-Visible), elemental analysis, and cell analyses with cancer cell line cultures. The results show good conjugation of the targeting molecule and the anticancer drug on the surface of the carbon nanotubes (CNT). This work demonstrates that the SWCNT-PTX-FA system is a potentially useful system for the targeted delivery of anticancer drugs.
authors.affiliation: a Department of Chemistry , Science and Research Branch, Islamic Azad University , Yazd , Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Tavakolifard
authors.affiliation: b Department of Biomaterials Engineering , Tonekabon Branch, Islamic Azad University , Tonekabon , Iran.
authors.forename: Esmaeil
authors.initials: E
authors.lastname: Biazar
authors.affiliation: c Department of Chemistry , Tonekabon Branch, Islamic Azad University , Tonekabon , Iran.
authors.forename: Khalil
authors.initials: K
authors.lastname: Pourshamsian
authors.affiliation: a Department of Chemistry , Science and Research Branch, Islamic Azad University , Yazd , Iran.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Moslemin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D061986:MCF-7 Cells; D037742:Nanotubes, Carbon / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D037742:Nanotubes, Carbon; D005492:Folic Acid; D017239:Paclitaxel
keywords: cell analyses; folic acid; functionalization; paclitaxel; single-wall carbon nanotubes