title: Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers.
abstract: Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Leslie
authors.initials: L
authors.lastname: Boudesocque-Delaye
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Agostinho
authors.affiliation: ‡Laboratoire Inflammation, Tissus Epithéliaux et Cytokines EA4331, Université de Poitiers, 86022 Poitiers, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Bodet
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Thery-Kone
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Hassan
authors.initials: H
authors.lastname: Allouchi
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Gueiffier
authors.affiliation: §Institut de Chimie Moléculaire de Reims UMR CNRS 7312, Université Reims Champagne-Ardenne, 51100 Reims, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nuzillard
authors.affiliation: †Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Enguehard-Gueiffier
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004642:Emodin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D016480:Helicobacter pylori / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009073:Mozambique; D019906:Nuclear Magnetic Resonance, Biomolecular; D035281:Plant Tubers / Q000737:chemistry; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D003374:Coumarins; D061065:Polyketides; C008905:physcione; D004642:Emodin