title: Total synthesis and structural revision of mycalol, an anticancer natural product from the marine source.
abstract: The total synthesis of an anticancer (anaplastic thyroid) natural lipid mycalol has been accomplished for the first time. Synthesis of originally proposed structure necessitated the revision of structure in which the position of acetate group moved from C20 to C19 and a change in stereochemistry of the glycerol unit.
authors.affiliation: †Division of Organic Chemistry and ‡Central NMR Facility, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: B
authors.initials: B
authors.lastname: Seetharamsingh
authors.affiliation: †Division of Organic Chemistry and ‡Central NMR Facility, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: P R
authors.initials: PR
authors.lastname: Rajamohanan
authors.affiliation: †Division of Organic Chemistry and ‡Central NMR Facility, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.
authors.forename: D Srinivasa
authors.initials: DS
authors.lastname: Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure; D013237:Stereoisomerism; D065646:Thyroid Carcinoma, Anaplastic / Q000737:chemistry* / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D005233:Fatty Alcohols; D008055:Lipids; C586897:mycalol; D005990:Glycerol