title: Solitary juvenile xanthogranuloma with tibial involvement: a case report.
abstract: Juvenile xanthogranuloma (JXG) is a rare disease that is part of a spectrum of histiocytic dendritic cell disorders. Most patients present with a solitary cutaneous lesion; however, others present with extracutaneous manifestations or even with systemic involvement. We present the first report of an 11-month-old girl in whom was diagnosed a unifocal extracutaneous JXG involving the tibia. Histological and immunohistochemical staining results are presented. A review of the literature on these unusual lesions is conducted, along with discussion of their differential diagnosis and key aspects of the patient's evaluation, management, and pathological diagnosis.
authors.affiliation: Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Yunlai
authors.initials: Y
authors.lastname: Zhi
authors.affiliation: Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Duan
authors.affiliation: Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yin
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Qu
authors.affiliation: Department of Organ Transplantation Center, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Guan
authors.affiliation: Digital Computer-aided Medicine and Surgery Key Laboratory, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Pediatric Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Dong
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D013977:Tibia / Q000473:pathology; D014972:Xanthogranuloma, Juvenile / Q000473:pathology*
keywords: Juvenile xanthogranuloma; Langerhans cell histiocytosis; tibia