title: Antitumoral materials with regenerative function obtained using a layer-by-layer technique.
abstract: A layer-by layer technique was successfully used to obtain collagen/hydroxyapatite-magnetite-cisplatin (COLL/HAn-Fe3O4-CisPt, n=1-7) composite materials with a variable content of hydroxyapatite intended for use in the treatment of bone cancer. The main advantages of this system are the possibility of controlling the rate of delivery of cytostatic agents, the presence of collagen and hydroxyapatite to ensure more rapid healing of the injured bone tissue, and the potential for magnetite to be a passive antitumoral component that can be activated when an appropriate external electromagnetic field is applied. In vitro cytotoxicity assays performed on the COLL/HAn-Fe3O4-CisPt materials obtained using a layer-by layer method confirmed their antitumoral activity. Samples with a higher content of hydroxyapatite had more antitumoral activity because of their better absorption of cisplatin and consequently a higher amount of cisplatin being present in the matrices.
authors.affiliation: Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania.
authors.forename: Denisa
authors.initials: D
authors.lastname: Ficai
authors.affiliation: Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania ; Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, Bucharest, Romania.
authors.forename: Maria
authors.initials: M
authors.lastname: Sonmez
authors.affiliation: Leather and Footwear Research Institute, National Research and Development Institute for Textiles and Leather, Bucharest, Romania.
authors.forename: Madalina Georgiana
authors.initials: MG
authors.lastname: Albu
authors.affiliation: Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania.
authors.forename: Dan Eduard
authors.initials: DE
authors.lastname: Mihaiescu
authors.affiliation: Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, Bucharest, Romania.
authors.forename: Anton
authors.initials: A
authors.lastname: Ficai
authors.affiliation: Stefan S Nicolau Institute of Virology, Romanian Academy, Bucharest, Romania.
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D003094:Collagen / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D017886:Durapatite / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D013329:Structure-Activity Relationship; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D003094:Collagen; D017886:Durapatite; D002945:Cisplatin; D052203:Ferrosoferric Oxide
keywords: antitumoral activity; bone grafts; multifunctional materials; scaffold