title: Increasing body mass index identifies Chinese patients with type 2 diabetes mellitus at risk of poor outcomes.
abstract: OBJECTIVE
  Association between body mass index (BMI) and glycemic control, comorbidities/complications, and health-related quality of life (HRQoL) was assessed in Chinese patients with type 2 diabetes mellitus (T2DM) enrolled in the Diabetes Disease Specific Programme.
  
  
  METHODS
  Surveys of 200 physicians and 2052 patients with T2DM captured demographic, clinical, and HRQoL information. Adjusted and unadjusted analyses were conducted across 3 BMI groups; normal (18.5-<24.0, n=998), overweight (24.0-<28.0, n=822), and obese (≥28.0, n=212).
  
  
  RESULTS
  There were no between group differences in the achievement of glycated hemoglobin (HbA1c) <7.0% (48mmol/mol); however, compared with the normal BMI group, more obese patients had an HbA1c >9.0% (75mmol/mol; 4.3% vs 10.2%, P=0.002). More obese patients compared with normal BMI patients had hypertension (48.6% vs 35.3%, P<0.001), dyslipidemia (35.4% vs 18.8%, P<0.001), or both hypertension and dyslipidemia (24.1% vs 13.9%, P<0.001). Patients in the obese group reported worse HRQoL and greater effects of diabetes on their daily living.
  
  
  CONCLUSIONS
  Obesity in Chinese patients with T2DM results in poor glycemic control, more comorbidities, and worse HRQoL. Management of these patients should include efforts to reduce weight. Selection of weight-neutral or weight-reducing anti-diabetic medications maybe useful in these patients.
authors.affiliation: Department of Endocrinology and Metabolism, Peking University People's Hospital, Beijing, China.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
authors.affiliation: Endocrinology Department, Affiliated Changhai Hospital to the 2nd Military Medical University, Shanghai, China.
authors.forename: Dajin
authors.initials: D
authors.lastname: Zou
authors.affiliation: Medical Division, Lilly Suzhou Pharmaceutical Co., Ltd, Shanghai, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Medical Division, Lilly Suzhou Pharmaceutical Co., Ltd, Shanghai, China. Electronic address: qian_lei_sh@lilly.com.
authors.forename: Lei
authors.initials: L
authors.lastname: Qian
authors.affiliation: Eli Lilly and Co., Real World Analytics, Vienna, Austria.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Kadziola
authors.affiliation: Eli Lilly and Co., Indianapolis, IN, USA.
authors.forename: Steven
authors.initials: S
authors.lastname: Babineaux
authors.affiliation: Medical Division, Lilly Suzhou Pharmaceutical Co., Ltd, Shanghai, China.
authors.forename: He Na
authors.initials: HN
authors.lastname: Zhang
authors.affiliation: Adelphi Real World, Bollington, Cheshire, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Wood
mesh_terms: D000203:Activities of Daily Living; D044466:Asian People / Q000706:statistics & numerical data; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D048909:Diabetes Complications / Q000175:diagnosis* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose
keywords: Body mass index; China; Diabetes mellitus; Obesity; Quality of life