title: Comparative Susceptibility of Aedes albopictus and Aedes aegypti to Dengue Virus Infection After Feeding on Blood of Viremic Humans: Implications for Public Health.
abstract: Aedes albopictus is secondary to Aedes aegypti as a vector of dengue viruses (DENVs) in settings of endemicity, but it plays an important role in areas of dengue emergence. This study compared the susceptibility of these 2 species to DENV infection by performing 232 direct blood-feeding experiments on 118 viremic patients with dengue in Vietnam. Field-derived A. albopictus acquired DENV infections as readily as A. aegypti after blood feeding. Once infected, A. albopictus permitted higher concentrations of DENV RNA to accumulate in abdominal tissues, compared with A. aegypti. However, the odds of A. albopictus having infectious saliva were lower than the odds observed for A. aegypti (odds ratio, 0.70; 95% confidence interval, .52-.93). These results quantitate the susceptibility of A. albopictus to DENV infection and will assist parameterization of models for predicting disease risk in settings where A. albopictus is present.
authors.affiliation: London School of Hygiene and Tropical Medicine Oxford University Clinical Research Unit.
authors.forename: James
authors.initials: J
authors.lastname: Whitehorn
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Duong Thi Hue
authors.initials: DT
authors.lastname: Kien
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Nguyet Minh
authors.initials: NM
authors.lastname: Nguyen
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Hoa L
authors.initials: HL
authors.lastname: Nguyen
authors.affiliation: University of Melbourne, Australia.
authors.forename: Peter P
authors.initials: PP
authors.lastname: Kyrylos
authors.affiliation: Oxford University Clinical Research Unit University of Melbourne, Australia.
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Carrington
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Chau Nguyen Bich
authors.initials: CN
authors.lastname: Tran
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Nguyen Thanh Ha
authors.initials: NT
authors.lastname: Quyen
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Long Vo
authors.initials: LV
authors.lastname: Thi
authors.affiliation: Oxford University Clinical Research Unit.
authors.forename: Dui
authors.initials: D
authors.lastname: Le Thi
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Nguyen Thanh
authors.initials: NT
authors.lastname: Truong
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Tai Thi Hue
authors.initials: TT
authors.lastname: Luong
authors.affiliation: Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Chau Van Vinh
authors.initials: CV
authors.lastname: Nguyen
authors.affiliation: Oxford University, United Kingdom Oxford University Clinical Research Unit.
authors.forename: Bridget
authors.initials: B
authors.lastname: Wills
authors.affiliation: Oxford University, United Kingdom Oxford University Clinical Research Unit.
authors.forename: Marcel
authors.initials: M
authors.lastname: Wolbers
authors.affiliation: Oxford University, United Kingdom Oxford University Clinical Research Unit University of Melbourne, Australia.
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
mesh_terms: D000328:Adult; D000330:Aedes / Q000821:virology*; D000818:Animals; D003715:Dengue / Q000635:transmission* / Q000821:virology; D003716:Dengue Virus / Q000502:physiology*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000821:virology*; D008297:Male; D011634:Public Health; D014744:Vietnam; D014766:Viremia / Q000821:virology; D055815:Young Adult
keywords: Aedes aegypti; Aedes albopictus; Dengue; susceptibility; transmission