title: Synchronous of gastric adenocarcinoma and schwannoma: report of a case and review of literatures.
abstract: We presented a case of 80-year-old male with long term stomachache, marasmus and anaemia. Endoscopic evaluation suggested the malignant ulcerative tumor on the Gastric antrum, and biopsy confirmed the diagnosis of gastric adenocarcinoma. Surprisingly, in resected specimen the pathologist found a nodule just below the ulcer with clear boundary and gray-yellow section. Histologically, the whole lesion was composed with adenocarcinoma area and spindle tumor cells area. In the spindle tumor cells area, the cells with round or oval nuclei, eosinophilic cytoplasm, and these cells showed bundle or fence-like arrangement. Immunohistochemistry study presented positive expression of vimentin, S-100 and GFAP, negative expression of SMA, desmin, CD34, CD117 and Dog-1, which suggested the diagnosis of co-occurrence of gastric adenocarcinoma and schwannoma. To our knowledge, it is an extremely rare case that only two cases have been reported.
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Lian-He
authors.initials: LH
authors.lastname: Yang
authors.affiliation: Department of Pathology, Shengjing Hospital of China Medical University China.
authors.forename: Jin-Ou
authors.initials: JO
authors.lastname: Wang
authors.affiliation: Department of Neurology, Shengjing Hospital of China Medical University China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, China Medical University China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Ultrasound, Shengjing Hospital of China Medical University China.
authors.forename: Jia-Xing
authors.initials: JX
authors.lastname: Sun
authors.affiliation: Department of Radiotherapy, First Affiliated Hospital, China Medical University China.
authors.forename: Si-Lu
authors.initials: SL
authors.lastname: Ding
authors.affiliation: Department of Radiotherapy, First Affiliated Hospital, China Medical University China.
authors.forename: Guang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Xu
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Sun-Dong
authors.initials: SD
authors.lastname: Dai
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Miao
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Gui-Yang
authors.initials: GY
authors.lastname: Jiang
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: Chui-Feng
authors.initials: CF
authors.lastname: Fan
authors.affiliation: Department of Pathology, First Affiliated Hospital and College of Basic Medicine Sciences, China Medical University China.
authors.forename: En-Hua
authors.initials: EH
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Gastric; adenocarcinoma; histological; pathology; schwannoma