title: [The influence of combined therapy with calcium antagonist and angiotensin-converting enzyme inhibitor on the circadian profile of arterial pressure in patients with arterial hypertension in the Far North].
abstract: OBJECTIVE
  To study effect of combined therapy with amlodipine with ramipril on the circadian profile of arterial pressure in patients with arterial hypertension in the Far North depending on the shiftwork regime.
  
  
  METHODS
  130 patients with grade 2-3 AH were divided into 2 groups depending on the work-time schedule. Group 1 included 67 daywork patients group 2 consisted of 63 patients working in the alternating daywork and nightwork regime. 24 hr AH monitoring was performed before, 4 weeks and 6 months after the onset of the study.
  
  
  RESULTS
  Six months after the onset of therapy practically all patients reached the target AD level (94.4% in group 1 and 94.7% in group). The patients fairly well tolerated therapy AD circadian profile was normalized 1.9 times in group 1 and 3.2 times in group 2. Recovered AP variability in group 1 resulted in a decreased frequency of target organ affection. In group 2, the initially higher variability accounted for the normalization of only diastolic AP variability after 6 month therapy. It suggests the necessity of prescription of a third anti-AH preparation to these patients. Morning AP dynamics improved in both groups.
authors.forename: I L
authors.initials: IL
authors.lastname: Zapesochnaia
authors.forename: A G
authors.initials: AG
authors.lastname: Avtandilov
mesh_terms: D000328:Adult; D017311:Amlodipine / Q000008:administration & dosage*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage; D057906:Circadian Clocks / Q000187:drug effects*; D003081:Cold Climate; D016903:Drug Monitoring / Q000379:methods; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017257:Ramipril / Q000008:administration & dosage*; D012720:Severity of Illness Index; D012800:Siberia; D016896:Treatment Outcome
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers; D017311:Amlodipine; D017257:Ramipril