title: Intralipid therapy for inadvertent peripheral nervous system blockade resulting from local anesthetic overdose.
abstract: Although local anesthetics have an acceptable safety profile, significant morbidity and mortality have been associated with their use. Inadvertent intravascular injection of local anesthetics and/or the use of excessive doses have been the most frequent causes of local anesthetic systemic toxicity (LAST). Furthermore, excessive doses of local anesthetics injected locally into the tissues may lead to inadvertent peripheral nerve infiltration and blockade. Successful treatment of LAST with intralipid has been reported. We describe a case of local anesthetic overdose that resulted in LAST and in unintentional blockade of peripheral nerves of the lower extremity; both effects completely resolved with administration of intralipid.
authors.affiliation: Temple University School of Medicine, 3401 N. Broad Street, 3rd Floor Outpatient Building, Zone B, Philadelphia, PA 19140, USA.
authors.forename: Ihab
authors.initials: I
authors.lastname: Kamel
authors.affiliation: Temple University School of Medicine, 3401 N. Broad Street, 3rd Floor Outpatient Building, Zone B, Philadelphia, PA 19140, USA.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Trehan
authors.affiliation: Temple University School of Medicine, 3401 N. Broad Street, 3rd Floor Outpatient Building, Zone B, Philadelphia, PA 19140, USA.
authors.forename: Rodger
authors.initials: R
authors.lastname: Barnette