title: α2-Adrenoceptors in the treatment of major neuropsychiatric disorders.
abstract: Presynaptic autoreceptors mediate a retrograde transfer of information by a negative feedback mechanism mediated by the transmitter of the neuron, and fulfill an autoregulatory function in neurotransmission in the peripheral and central nervous system (CNS). Starting with norepinephrine (NE), it was later reported that an autoreceptor-mediated negative feedback mechanism exists for other neurotransmitters, including dopamine (DA), serotonin, acetylcholine, histamine, GABA, and glutamate. This feedback mechanism regulates calcium-dependent transmitter release and synthesis through terminal presynaptic autoreceptors, while the firing rate of the neuron is regulated through somatodendritic autoreceptors.
authors.affiliation: Synaptic Pharma Ltd, 8 Herzel Rosenblum St Apt 4650, Tel Aviv 69379, Israel. Electronic address: langer.salomon@gmail.com.
authors.forename: Salomon Z
authors.initials: SZ
authors.lastname: Langer
mesh_terms: D000818:Animals; D017660:Autoreceptors / Q000037:antagonists & inhibitors / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D017660:Autoreceptors; D001688:Biological Products; D018341:Receptors, Adrenergic, alpha-2; D004298:Dopamine; D009638:Norepinephrine
keywords: ADHD; Alzheimer's disease; bipolar disorder; depression; presynaptic autoreceptors; presynaptic heteroreceptors; schizophrenia