title: Pathogenesis of innate immunity and adaptive immunity in the mouse model of experimental autoimmune uveitis.
abstract: Experimental autoimmune uveitis, a well-established model for human uveitis, is similar to human uveitis in many pathological features. Studies concerning the mechanisms of experimental autoimmune uveitis would cast a light on the pathogenesis of human uveitis as well as the search for more effective therapeutic agents. The cellular components of innate immunity include natural killer cells, gamma delta T lymphocytes, antigen-presenting dendritic cells, phagocytic macrophages, and granulocytes. It is believed that T cells are central in the generation of human uveitis. It has already become clear that CD4(+) effecter cells that predominantly produce interleukin-17 (the so-called Th17 cells) may play an important role in uveitis. In addition, the occurrence and recurrence of uveitis depends on a complex interplay between the elements of innate and adaptive immunity.
authors.affiliation: Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China; Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Bi
authors.affiliation: Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
authors.forename: Zheng-Feng
authors.initials: ZF
authors.lastname: Liu
authors.affiliation: Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China; Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China. Electronic address: cuiyan_1972@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000096:biosynthesis; D051379:Mice; D055611:Natural Killer T-Cells / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta; D014605:Uveitis / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: adaptive immunity; experimental autoimmune uveitis; innate immunity; pathogenesis; uveitis