title: [Severe acute kidney injury in critically ill children: Epidemiology and prognostic factors].
abstract: BACKGROUND
  Acute kidney injury (AKI) is a severe complication in critically ill children. The aim of the study was to describe the characteristics of AKI, as well as to analyse the prognostic factors for mortality and renal replacement therapy (RRT) in children admitted to Paediatric Intensive Care Units (PICUs) in Spain.
  
  
  METHODS
  Prospective observational multicentre study including children from 7 days to 16 years old who were admitted to a PICU. A univariate and multivariate logistic regression analysis of the risk factors for mortality and renal replacement therapy at PICU discharge were performed.
  
  
  RESULTS
  A total of 139 cases of AKI were analysed. RRT was necessary in 60.1% of cases. Mortality rate was 32.6%. At PICU discharge RRT was necessary in 15% of survivors. Thrombopenia and low creatinine clearance values were prognostic markers of RRT at PICU discharge. High values of platelets, serum creatinine and weight were associated with higher survival.
  
  
  CONCLUSIONS
  Critically ill children with AKI had a high mortality and morbidity rate. Platelet values and creatinine clearance are markers of RRT at PICU discharge, whereas number of platelets, serum creatinine and weight were associated with mortality.
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Madrid Torrelodones, Torrelodones, Madrid, España. Electronic address: tousrula@yahoo.es.
authors.forename: P
authors.initials: P
authors.lastname: Touza Pol
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Central de Asturias, Oviedo, Asturias, España; Departamento de Medicina, Universidad de Oviedo, Oviedo, España.
authors.forename: C
authors.initials: C
authors.lastname: Rey Galán
authors.affiliation: Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Medina Villanueva
authors.affiliation: Oficina de Investigación Biosanitaria de Asturias (OIB) , Chile; Universidad Autónoma de Chile, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Martinez-Camblor
authors.affiliation: Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Red de Salud Maternoinfantil y del Desarrollo, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: López-Herce
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000453:epidemiology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011379:Prognosis; D011446:Prospective Studies; D017582:Renal Replacement Therapy; D013030:Spain
keywords: Acute kidney injury; Daño renal agudo; Depuración extrarrenal; Mortalidad; Mortality; Outcome; Paediatric Intensive Care Units; Pronóstico; Renal replacement therapy; Unidades de Cuidados Intensivos Pediátricos