title: Malignant peripheral nerve sheath tumour (MPNST) of mandible: solving the perplexity.
abstract: We present an extremely rare case of malignant peripheral nerve sheath tumour (MPNST) in a 30-year-old woman without associated neurofibromatosis 1. The patient presented with an 8 cm×4 cm lesion extending from 46 to the retro molar region involving the ramus of the right mandible associated with regional paraesthesia. Incisional biopsy revealed spindle cells with vesicular nuclei arranged in fascicles leading to a diagnosis of spindle cell lesion. Posterior segmental mandibulectomy was performed under general anaesthesia. On excisional biopsy, a definitive diagnosis of low-grade MPNST was established on the basis of immunohistochemistry. The patient was then lost to follow-up.
authors.affiliation: Department of Oral Pathology, MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Oral Pathology, MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.
authors.forename: Jigna
authors.initials: J
authors.lastname: Pathak
authors.affiliation: MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.
authors.forename: Kamlesh
authors.initials: K
authors.lastname: Dekate
authors.affiliation: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Neeta
authors.initials: N
authors.lastname: Mohanty
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D059012:Lost to Follow-Up; D008334:Mandible / Q000473:pathology* / Q000601:surgery; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor