title: Cascade couplings of N-alkyl-N-methacryloyl benzamides with ethers and benzenesulfonohydrazides to generate isoquinoline-1,3(2H,4H)-dione derivatives.
abstract: Two radical-mediated cascade couplings of N-alkyl-N-methacryloylbenzamides with different ethers and arylsulfonohydrazides to generate ether- and arylsulfonyl-substituted isoquinoline-1,3(2H,4H)-dione derivatives were developed. Both casccades proceeded via initially triggered functionalization of the alkene functions of the N-alkyl-N-methacryloylbenzamides, followed by ortho radical cyclizations onto the aromatic ring to give isoquinoline-1,3(2H,4H)-dione derivatives in good yields. These highly functionalized drug-like molecules will be valuable in drug discovery in the future.
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.affiliation: ‡Scientific Information Research Institute, Jiangsu University (Library), Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Wannian
authors.initials: W
authors.lastname: Zhao
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Ben
authors.initials: B
authors.lastname: Niu
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Zhaogang
authors.initials: Z
authors.lastname: Bian
authors.affiliation: §Department of Chemistry, Mississippi State University, Mississippi State, Mississippi 39762, United States.
authors.forename: Charles U
authors.initials: CU
authors.lastname: Pittman
authors.affiliation: †Pharmacy School, Jiangsu University, Xuefu Road 301, Zhenjiang City, Jiangsu, China 212013.
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhou
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D003500:Cyclization; D004987:Ethers / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C472069:1,3(2H,4H)-isoquinolinedione; D001549:Benzamides; D004987:Ethers; D007546:Isoquinolines; D008689:Methacrylates