title: Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.
abstract: BACKGROUND
  For the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.
  
  
  METHODS
  We genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.
  
  
  RESULTS
  No evidence of association was detected.
  
  
  CONCLUSIONS
  There are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Marcella
authors.initials: M
authors.lastname: Martinelli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Scapoli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy.
authors.forename: Angela Maria Grazia
authors.initials: AM
authors.lastname: Pacilli
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Carbonara
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Ambra
authors.initials: A
authors.lastname: Girardi
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Mattei
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Rodia
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Solmi
keywords: Idiopathic pulmonary fibrosis; multidrug resistance 1 gene; polymorphism