title: CD5 helps aspiring regulatory T cells ward off unwelcome cytokine advances.
abstract: The role of co-receptor molecules in the generation of inducible regulatory T cells (iTregs) remains incompletely defined. In this issue of Immunity, Henderson et al. (2015) show that CD5 regulates iTreg cell induction by rendering emerging iTreg cells refractory to signals mediated by effector-differentiating cytokines.
authors.affiliation: Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Amy C
authors.initials: AC
authors.lastname: Palin
authors.affiliation: Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: lovep@mail.nih.gov.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Love
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D018956:CD5 Antigens / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism*
chemical_list: D001324:Autoantigens; D018956:CD5 Antigens; C526836:Cd5 protein, mouse