title: Genetic predisposition of stroke: understanding the evolving landscape through meta-analysis.
abstract: Stroke, either ischemic or hemorrhagic, is the leading cause of death and morbidity worldwide. Identifying the risk factors is a prerequisite step for stroke prevention and treatment. It is believed that a major portion of the currently unidentified risk factors is of genetic origin. Consistent with this idea, numerous potential risk alleles for stroke have been reported, however, the genetic evidence so far is not conclusive. The major goal of this review is to update the current knowledge about the genetic predisposition to the common multifactorial stroke, and to provide a bird's-eye view of this fast moving field. We selectively review and meta-analyze the related English literatures in public domain (PubMed) from 2000 onward, including the original reports and meta-analyses, to evaluate the genetic risk factors of common multifactorial stroke. The results indicated that we reviewed and meta-analyzed original reports and existing meta-analyses that studied the genetic predisposition to the common multifactorial stroke. Some original reports and meta-analyses were specific for ischemic stroke and others were for hemorrhagic stroke only. We also evaluated the major evolving issues in this field and discussed the future directions. In conclusion, strong evidences suggest that genetic risk factors contribute to common multifactorial stroke, and many genetic risk genes have been implicated in the literatures. However, not a single risk allele has been conclusively approved.
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Hai-Dong
authors.initials: HD
authors.lastname: Huang
authors.affiliation: Department of Medical Imaging, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Chun-Min
authors.initials: CM
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Shu
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Yong-Qin
authors.initials: YQ
authors.lastname: Kuang
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Wei-Qi
authors.initials: WQ
authors.lastname: He
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Cheng
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, General Hospital of The People's Liberation Army Chengdu Military Region Sichuan 610083, China.
authors.forename: Jian-Wen
authors.initials: JW
authors.lastname: Gu
keywords: Genetic predisposition/risk; hemorrhagic stroke; ischemic stroke