title: Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows.
abstract: Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased.
authors.affiliation: Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.
authors.forename: Bhuminad
authors.initials: B
authors.lastname: Devkota
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Saori
authors.initials: S
authors.lastname: Sato
authors.forename: Kouya
authors.initials: K
authors.lastname: Sasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ueki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Osawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Norio
authors.initials: N
authors.lastname: Yamagishi
mesh_terms: D000135:Acid Phosphatase / Q000097:blood* / Q000502:physiology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001862:Bone Resorption / Q000097:blood / Q000503:physiopathology / Q000662:veterinary; D002118:Calcium / Q000097:blood; D002417:Cattle / Q000097:blood* / Q000502:physiology; D024042:Collagen Type I / Q000097:blood* / Q000502:physiology; D004958:Estradiol / Q000097:blood* / Q000502:physiology; D005260:Female; D006909:Hydroxyproline / Q000097:blood; D007527:Isoenzymes / Q000097:blood* / Q000502:physiology; D010281:Parathyroid Hormone / Q000097:blood; D036801:Parturition / Q000097:blood* / Q000502:physiology; D010455:Peptides / Q000097:blood* / Q000502:physiology; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D007527:Isoenzymes; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D004958:Estradiol; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase; D006909:Hydroxyproline; D002118:Calcium