title: Redox signaling in acute pancreatitis.
abstract: Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On the other hand, the release of extracellular hemoglobin into the circulation from the ascitic fluid in severe necrotizing pancreatitis enhances lipid peroxidation in plasma and the inflammatory infiltrate into the lung and up-regulates the HIF-VEGF pathway, contributing to the systemic inflammatory response. Therefore, redox signaling and oxidative stress contribute to the local and systemic inflammatory response during acute pancreatitis.
authors.affiliation: Department of Physiology, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Pérez
authors.affiliation: Department of Physiology, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Pereda
authors.affiliation: Department of Surgery, University of Valencia, Universitary Clinic Hospital, Av. Blasco Ibáñez 17, 46010 Valencia, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Sabater
authors.affiliation: Department of Physiology, University of Valencia, Avda. Vicente Andrés Estellés s/n, 46100 Burjassot, Spain. Electronic address: juan.sastre@uv.es.
authors.forename: Juan
authors.initials: J
authors.lastname: Sastre
mesh_terms: D000208:Acute Disease; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010195:Pancreatitis / Q000378:metabolism / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016328:NF-kappa B; D017382:Reactive Oxygen Species; D002118:Calcium
keywords: Acute inflammation; Acute pancreatitis; Glutathione; Oxidative stress