title: Comparison of benazepril and losartan on endothelial function and vascular stiffness in patients with Type 2 diabetes mellitus and hypertension: A randomized controlled trial.
abstract: BACKGROUND
  The purpose of this study was to compare the effects of benazepril and losartan on endothelial function and vascular stiffness, in patients with diabetes mellitus and hypertension.
  
  
  METHODS
  We included hypertensive diabetic patients with an office systolic blood pressure (BP) ⩾ 130 mmHg and/or diastolic BP ⩾ 80 mmHg. Patients were rolled over to amlodipine for 6 weeks, then we performed C-reactive protein assays, BP measurement and vascular tests; next, patients were randomized to benazepril or losartan. The tests were repeated after 12 weeks.
  
  
  RESULTS
  We randomized 14 patients to benazepril and 16 to losartan. There were no differences in systolic (139 versus 134 mmHg, p = 0.618) and diastolic (82 versus 80 mmHg, p = 0.950) BP at the end of the study. C-reactive protein values were lower in the benazepril group (0.38 versus 0.42 mg/dl, p = 0.020). There was a slightly higher flow-mediated vasodilation (FMD) response in the benazepril group (45% increase, p = 0.057) than in the losartan group (19% increase, p = 0.132). Both central systolic BP (129 versus 123 mmHg, p = 0.934) and carotid-femoral pulse wave velocity (cfPWV) (8.5 versus 8.5 m/s, p = 0.280) were the same between groups.
  
  
  CONCLUSIONS
  Hypertensive diabetic patients using benazepril had a greater reduction in C-reactive protein, and a slight improvement in FMD, than those taking losartan.
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil ronaldogismondi@gmail.com.
authors.forename: Ronaldo A O C
authors.initials: RA
authors.lastname: Gismondi
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Wille
authors.initials: W
authors.lastname: Oigman
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Bedirian
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Cesar R
authors.initials: CR
authors.lastname: Pozzobon
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Marcia C Boaventura
authors.initials: MC
authors.lastname: Ladeira
authors.affiliation: Department of Clinical Medicine, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: Mario F
authors.initials: MF
authors.lastname: Neves
mesh_terms: D001011:Aorta / Q000187:drug effects / Q000503:physiopathology; D001552:Benzazepines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002097:C-Reactive Protein; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D019808:Losartan / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000187:drug effects*
chemical_list: D001552:Benzazepines; D002097:C-Reactive Protein; D019808:Losartan; C044946:benazepril
keywords: Benazepril; C-reactive protein; blood pressure; comparison study; diabetes mellitus; endothelium; hypertension; losartan; renin-angiotensin system; vascular stiffness; vasodilation