title: Regulation of nicotinic acetylcholine receptors in Alzheimer׳s disease: a possible role of chaperones.
abstract: Nicotinic acetylcholine receptors (nAChRs) seem to play an integral role in the progress and/or prevention of Alzheimer׳s diseases (AD). Functional abnormalities and problems in biogenesis and trafficking of nAChRs are two major culprits in AD; on the other hand, chaperones modulate post-translational changes in nAChRs. Moreover, they indirectly regulate nAChRs by controlling AD-related proteins such as tau and amyloid beta (Aβ). In this review, we go through recent studies which are showing that chaperones modulate the expression of nAChRs in a subtype-specific manner and explain how AD progress is affected by nAChRs chaperoning.
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756 Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Sadigh-Eteghad
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756 Tabriz, Iran. Electronic address: alimaj1992@yahoo.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Majdi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756 Tabriz, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Talebi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756 Tabriz, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Mahmoudi
authors.affiliation: Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, P.O. Box: 5166614756 Tabriz, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Babri
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D018832:Molecular Chaperones; D011978:Receptors, Nicotinic
keywords: Alzheimer; Chaperone; Nicotinic acetylcholine receptors; Regulation