title: 0.9% saline induced hyperchloremic acidosis.
abstract: In the acute care setting, the type and amount of fluid administered has a significant impact on patient outcomes. In particular, 0.9% saline infusions are known to cause or exacerbate hyperchloremia. The studies presented evaluate possible complications from 0.9% saline infusions. These studies compared administration of 0.9% saline with lactated ringer or plasmalyte in the acute care setting. In each trial, the patients who were randomized to receive 0.9% saline infusions had a more severe acidosis from increased serum chloride levels. From the available data, chloride-restrictive intravenous fluid such as plasmalyte appears to reduce acid-base disturbances and improve patient outcomes.
authors.affiliation: Penn Presbyterian Medical Center, Philadelphia, PA.
authors.forename: Megan E
authors.initials: ME
authors.lastname: Barker
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000517:prevention & control; D003422:Critical Care / Q000379:methods*; D004573:Electrolytes / Q000008:administration & dosage; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015994:Incidence; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D011322:Primary Prevention / Q000379:methods; D016032:Randomized Controlled Trials as Topic; D012151:Resuscitation / Q000379:methods; D000077325:Ringer's Lactate; D018570:Risk Assessment; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000009:adverse effects*; D012965:Sodium Chloride / Q000097:blood*; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000628:therapy
chemical_list: D004573:Electrolytes; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; C048013:Plasmalyte A