title: Lung transplantation with donation after circulatory determination of death donors and the impact of ex vivo lung perfusion.
abstract: The growing demand for suitable lungs for transplantation drives the quest for alternative strategies to expand the donor pool. The aim of this study is to evaluate the outcomes of lung transplantation (LTx) with donation after circulatory determination of death (DCDD) and the impact of selective ex vivo lung perfusion (EVLP). From 2007 to 2013, 673 LTx were performed, with 62 (9.2%) of them using DCDDs (seven bridged cases). Cases bridged with mechanical ventilation/extracorporeal life support were excluded. From 55 DCDDs, 28 (51%) underwent EVLP. Outcomes for LTx using DCDDs and donation after neurological determination of death (DNDD) donors were similar, with 1 and 5-year survivals of 85% and 54% versus 86% and 62%, respectively (p = 0.43). Although comparison of survival curves between DCDD + EVLP versus DCDD-no EVLP showed no significant difference, DCDD + EVLP cases presented shorter hospital stay (median 18 vs. 23 days, p = 0.047) and a trend toward shorter length of mechanical ventilation (2 vs. 3 days, p = 0.059). DCDDs represent a valuable source of lungs for transplantation, providing similar results to DNDDs. EVLP seems an important technique in the armamentarium to safely increase lung utilization from DCDDs; however, further studies are necessary to better define the role of EVLP in this context.
authors.affiliation: Toronto Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada.
authors.forename: T N
authors.initials: TN
authors.lastname: Machuca
authors.forename: O
authors.initials: O
authors.lastname: Mercier
authors.forename: S
authors.initials: S
authors.lastname: Collaud
authors.forename: J
authors.initials: J
authors.lastname: Tikkanen
authors.forename: T
authors.initials: T
authors.lastname: Krueger
authors.forename: J C
authors.initials: JC
authors.lastname: Yeung
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Azad
authors.forename: L
authors.initials: L
authors.lastname: Singer
authors.forename: K
authors.initials: K
authors.lastname: Yasufuku
authors.forename: M
authors.initials: M
authors.lastname: de Perrot
authors.forename: A
authors.initials: A
authors.lastname: Pierre
authors.forename: T K
authors.initials: TK
authors.lastname: Waddell
authors.forename: S
authors.initials: S
authors.lastname: Keshavjee
authors.forename: M
authors.initials: M
authors.lastname: Cypel
mesh_terms: D000328:Adult; D001775:Blood Circulation; D005260:Female; D006801:Humans; D008168:Lung; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D011379:Prognosis; D012189:Retrospective Studies; D014019:Tissue Donors
keywords: clinical research / practice; donors and donation: donation after circulatory death (DCD); donors and donation: donor evaluation; lung transplantation / pulmonology; organ perfusion and preservation; organ procurement and allocation