title: Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 Educational Day.
abstract: Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor-bearing extracellular vesicles have been proposed as a possible explanation for the increased risk of VTE observed in some types of cancer. The International Society for Extracellular Vesicles (ISEV) and International Society on Thrombosis and Haemostasis (ISTH) held a joint Educational Day in April 2014 to discuss the latest developments in this field. This review discusses the themes of that event and the ISEV 2014 meeting that followed.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3 Women's Centre, John Radcliffe Hospital, Oxford, UK; chris.gardiner@obs-gyn.ox.ac.uk.
authors.forename: Chris
authors.initials: C
authors.lastname: Gardiner
authors.affiliation: School of Immunity and Infection, University of Birmingham Medical School, Birmingham, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Harrison
authors.affiliation: Department of Oncology and Pathology, Clinical Sciences, Skåne University Hospital, Lund, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Belting
authors.affiliation: Department of Clinical Chemistry, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Anita
authors.initials: A
authors.lastname: Böing
authors.affiliation: Department of Cardiologic, Thoracic and Vascular Sciences, University of Padua Medical School, Padua, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Campello
authors.affiliation: Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
authors.forename: Bob S
authors.initials: BS
authors.lastname: Carter
authors.affiliation: Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield General Hospital, Leicester, UK.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Collier
authors.affiliation: Department of Clinical Chemistry, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.|Department of Biomedical Engineering and Physics, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Frank
authors.initials: F
authors.lastname: Coumans
authors.affiliation: School of Biological, Biomedical and Environmental Sciences, The University of Hull, Hull, UK.
authors.forename: Camille
authors.initials: C
authors.lastname: Ettelaie
authors.affiliation: Department of Vascular Medicine, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Nick
authors.initials: N
authors.lastname: van Es
authors.affiliation: Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.|Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Fred H
authors.initials: FH
authors.lastname: Hochberg
authors.affiliation: Thrombosis and Hemostasis Program, Department of Medicine, UNC McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors.forename: Nigel
authors.initials: N
authors.lastname: Mackman
authors.affiliation: Division of Neurosurgery, University of California San Diego, La Jolla, CA, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rennert
authors.affiliation: Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Thaler
authors.affiliation: Department of Pediatrics, McGill University, Montreal Children's Hospital Research Institute MUHC, Montreal, QC, Canada.
authors.forename: Janusz
authors.initials: J
authors.lastname: Rak
authors.affiliation: Department of Clinical Chemistry, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Rienk
authors.initials: R
authors.lastname: Nieuwland
keywords: cancer; extracellular vesicles; thrombosis; tissue factor