title: Collision cross section measurements for biomolecules within a high-resolution FT-ICR cell: theory.
abstract: In this study, an energetic hard-sphere ion-neutral collision model was proposed to bridge-link ion collision cross section (CCS) with the image current collected from a high-resolution Fourier transform ion cyclotron resonance (FT-ICR) cell. By investigating the nonlinear effects induced by high-order electric fields and image charge forces, the energetic hard-sphere collision model was validated through experiments. Suitable application regions for the energetic hard-sphere collision model, as well as for the conventional Langevin and hard-sphere collision models, were also discussed. The energetic hard-sphere collision model was applied in the extraction of ion CCSs from high-resolution FT-ICR mass spectra. Discussions in the present study also apply to FT-Orbitraps and FT-quadrupole ion traps.
authors.affiliation: School of Life Science, Beijing Institute of Technology, Beijing 100081, China. weixu@bit.edu.cn.
authors.forename: Dan
authors.initials: D
authors.lastname: Guo
authors.forename: Yi
authors.initials: Y
authors.lastname: Xin
authors.forename: Dayu
authors.initials: D
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
mesh_terms: D017357:Cyclotrons; D006801:Humans; D007477:Ions / Q000032:analysis*; D008958:Models, Molecular; D008962:Models, Theoretical; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D025801:Ubiquitin / Q000032:analysis*; D014732:Vibration
chemical_list: D007477:Ions; D025801:Ubiquitin