title: Primary cerebral lymphomatoid granulomatosis progressing to methotrexate-associated lymphoproliferative disease under immunosuppressive therapy.
abstract: Lymphomatoid granulomatosis (LYG) is an angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites. Although LYG cerebral lesions are usually located adjacent to LYG pulmonary lesions, few reports have described the occurrence of primary cerebral LYG. We herein discuss a case of a 40-year-old Japanese woman with primary cerebral LYG that caused various neurological symptoms for more than five years and progressed to methotrexate-associated lymphoproliferative disease under treatment with immunosuppressive therapy. This case suggests that primary cerebral LYG should be considered a lymphoid neoplasm manifesting as a primary brain tumor and a component of the differential diagnosis of chronic neuroinflammatory disorders.
authors.affiliation: Department of Hematology, Oami Municipal Hospital, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shogo
authors.initials: S
authors.lastname: Furukawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeda
authors.forename: Naomi
authors.initials: N
authors.lastname: Shimizu
authors.forename: Takeharu
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Chika
authors.initials: C
authors.lastname: Kawajiri
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takagi
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ota
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008230:Lymphomatoid Granulomatosis / Q000188:drug therapy*; D008232:Lymphoproliferative Disorders / Q000139:chemically induced*; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate