title: miR-495 mediates metabolic shift in glioma cells via targeting Glut1.
abstract: Cancer cell metabolism is often characterized by a shift from an oxidative to a glycolytic bioenergetics pathway, a phenomenon known as the Warburg effect. Whether the deregulation of microRNAs contributes to the Warburg effect remains largely unknown. Here, we show that miR-495 expression is decreased and thus induces a metabolic shift in glioma cells. miR-495 performs this function by increasing the expression of Glut1, leading to the increase of glucose uptake and lactate production. The altered metabolism induced by miR-495 results in the rapid growth of cancer cells. These results identify miR-495 as a molecular switch involved in the orchestration of the Warburg effect in glioma cells via targeting the expression of Glut1.
authors.affiliation: From the First Hospital, Ning Bo, Zhejiang Province, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Nie
authors.forename: Keqin
authors.initials: K
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Qinle
authors.initials: Q
authors.lastname: Hu
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Sun
authors.initials: S
authors.lastname: Jie
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000235:genetics / Q000378:metabolism*; D006019:Glycolysis / Q000235:genetics; D057809:HEK293 Cells; D006801:Humans; D019344:Lactic Acid / Q000096:biosynthesis; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D051272:Glucose Transporter Type 1; C577768:MIRN495 microRNA, human; D035683:MicroRNAs; C495677:SLC2A1 protein, human; D019344:Lactic Acid; D005947:Glucose