title: 3D time-resolved vessel-selective angiography based on pseudo-continuous arterial spin labeling.
abstract: Angiographic imaging is an important diagnostic tool for the assessment of the intracranial arterial status. Using arterial spin labeling (ASL) techniques, it is possible to visualize the arteries without the administration of exogenous contrast agents. Moreover, modifications of the labeling method allow for the visualization of single arterial trees. In this study, an approach is presented for time-resolved MR angiography based on superselective ASL and keyhole accelerated image acquisition in order to selectively visualize individual cerebral arteries in a clinically acceptable scan time. Keyhole percentage as well as the flip angle of the acquisition sequence was optimized in numerical simulations. Subsequently, the method was validated in healthy volunteers. As a result, image acquisition in 5 minutes with a temporal resolution of 100 ms and spatial resolution below 1 mm was achieved.
authors.affiliation: Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, Kiel, Germany. Electronic address: Thomas.Lindner@uksh.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Lindner
authors.affiliation: Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, Kiel, Germany.
authors.forename: Ulf
authors.initials: U
authors.lastname: Jensen-Kondering
authors.affiliation: C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: Matthias J P
authors.initials: MJ
authors.lastname: van Osch
authors.affiliation: Clinic for Radiology and Neuroradiology, UKSH Campus Kiel, Kiel, Germany.
authors.forename: Olav
authors.initials: O
authors.lastname: Jansen
authors.affiliation: Philips GmbH Innovative Technologies, Research Laboratories, Hamburg, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Helle
mesh_terms: D000328:Adult; D002536:Cerebral Arteries / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D012016:Reference Values; D013113:Spin Labels
chemical_list: D013113:Spin Labels
keywords: Angiography; Arterial spin labeling; Intracranial; Keyhole; Non contrast enhanced; Selective