title: Accumulation of lipid in rat liver was induced by vitamin B₆ deficiency and was ameliorated by supplemental phosphatidylcholine in the diet.
abstract: We investigated the efficacy of supplementing the diet with pteroylmonoglutamic acid (PGA), choline, or phosphatidylcholine (PC) in ameliorating the lipid accumulation in rat liver that is induced by vitamin B6 (B6) deficiency. In Experiment 1, male Wistar rats were fed a control, B6-deficient, or PGA-, choline-, or PC-supplemented (10 mg, 4 g, and 6.3 g/kg of diet, respectively) B6-deficient diet containing l-methionine at 9 g/kg of diet for 35 days. In Experiment 2, rats were fed a control, B6-deficient, or PC-supplemented (at 3.15, 6.3, or 12.6 g PC/kg of diet) B6-deficient diet for 35 days. Choline or PC supplementation ameliorated liver lipid deposition and returned plasma lipids to normal. Judging from these results, it appeared that B6 deficiency decreased the synthesis of PC in the liver, thereby decreasing the secretion of very low-density lipoproteins, and in consequence producing lipid accumulation in the liver and reductions of plasma lipids.
authors.affiliation: a The United Graduate School of Agricultural Science , Gifu University , Gifu , Japan.
authors.forename: Erina
authors.initials: E
authors.lastname: Kitagawa
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D000818:Animals; D019587:Dietary Supplements; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D051381:Rats; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000378:metabolism; D026681:Vitamin B 6 Deficiency / Q000178:diet therapy
chemical_list: D008079:Lipoproteins, VLDL; D010713:Phosphatidylcholines; D025101:Vitamin B 6
keywords: liver lipids; methionine metabolism; phosphatidylcholine; very low-density lipoprotein (VLDL); vitamin B6 deficiency