title: Bazedoxifene/conjugated estrogens combination for the treatment of the vasomotor symptoms associated with menopause and for prevention of osteoporosis in postmenopausal women.
abstract: The decrease of estrogen in postmenopausal women has been associated with the presence of different symptoms such as vasomotor symptoms, vulvovaginal atrophy, bone loss, sleep disturbances, and mood and sexual activity alterations. Hormone replacement therapy with estrogen and progestins has been used to improve menopausal symptoms; however, there are still concerns regarding its safety and tolerability, as some progestins have been shown to increase breast cancer and cardiovascular risk. Bazedoxifene is a third-generation selective estrogen receptor modulator (SERM) used for osteoporosis management in postmenopausal women at fracture risk that has demonstrated a powerful antiestrogenic effect on the endometrium. Today we have a new alternative called the tissue-selective estrogen complex (TSEC), which combines bazedoxifene and conjugated estrogens and is designed not only to improve menopausal symptoms and vulvovaginal atrophy but also to prevent bone loss. Therefore, it maintains the benefits of estrogen therapy while antagonizing the stimulation effects on the endometrium and mammary gland without the effects associated with progestins.
authors.affiliation: Palacios Institute of Women's Health, Madrid, Spain. ipalacios@institutopalacios.com.
authors.forename: S
authors.initials: S
authors.lastname: Palacios
authors.affiliation: Palacios Institute of Women's Health, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Mejía Ríos
mesh_terms: D015519:Bone Density / Q000187:drug effects; D004359:Drug Therapy, Combination; D004966:Estrogens, Conjugated (USP) / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage*
chemical_list: D004966:Estrogens, Conjugated (USP); D007211:Indoles; D020845:Selective Estrogen Receptor Modulators; C447119:bazedoxifene
keywords: Bazedoxifene; Conjugate estrogens; Progestins; TSEC; Tissue-selective estrogen complex