title: Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo.
abstract: Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.
authors.affiliation: Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China.|Department of Neurosurgery, The Xijing Hospital of The Fourth Miltary Medical University, Xi'an, China.
authors.forename: Niu
authors.initials: N
authors.lastname: Zhanfeng
authors.affiliation: Graduate School of Ningxia Medical University, Yinchuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yanhui
authors.affiliation: Department of Neurosurgery, The Xijing Hospital of The Fourth Miltary Medical University, Xi'an, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Shaocai
authors.affiliation: Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Guangxing
authors.affiliation: Department of Neurosurgery, The General Hospital of Ningxia Medical University, Yinchuan, China.|Incubation Base of National Key Laboratory for Cerebrocranial Diseases, Ningxia Medical University, Yinchuan, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Hechun
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D002940:Circadian Rhythm / Q000235:genetics*; D005910:Glioma / Q000235:genetics* / Q000378:metabolism / Q000469:parasitology / Q000532:radiotherapy; D008297:Male; D056950:Period Circadian Proteins / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011836:Radiation Tolerance / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: C539024:Per1 protein, rat; C513311:Per2 protein, rat; D056950:Period Circadian Proteins; D012333:RNA, Messenger
keywords: Per1; Per2; glioma; radiotherapeutic sensitivity