title: A population study of binocular function.
abstract: As part of a genome-wide association study (GWAS) of perceptual traits in healthy adults, we measured stereo acuity, the duration of alternative percepts in binocular rivalry and the extent of dichoptic masking in 1060 participants. We present the distributions of the measures, the correlations between measures, and their relationships to other psychophysical traits. We report sex differences, and correlations with age, interpupillary distance, eye dominance, phorias, visual acuity and personality. The GWAS, using data from 988 participants, yielded one genetic association that passed a permutation test for significance: The variant rs1022907 in the gene VTI1A was associated with self-reported ability to see autostereograms. We list a number of other suggestive genetic associations (p<10(-5)).
authors.affiliation: Department of Psychology, University of Cambridge, UK; School of Psychology, University of Sussex, Brighton, UK. Electronic address: J.Bosten@sussex.ac.uk.
authors.forename: J M
authors.initials: JM
authors.lastname: Bosten
authors.affiliation: Department of Psychology, University of Cambridge, UK; School of Psychology, University of Sydney, Australia.
authors.forename: P T
authors.initials: PT
authors.lastname: Goodbourn
authors.affiliation: Department of Psychology, University of Cambridge, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lawrance-Owen
authors.affiliation: Department of Psychology, University of Cambridge, UK; Division of Optometry and Visual Science, City University, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Bargary
authors.affiliation: Department of Psychology, University of Cambridge, UK; Centre for Experimental Medicine, Queen's University Belfast, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Hogg
authors.affiliation: Department of Psychology, University of Cambridge, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Mollon
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015350:Contrast Sensitivity / Q000502:physiology; D023882:Dominance, Ocular / Q000502:physiology; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D010470:Perceptual Masking / Q000502:physiology; D011601:Psychophysics; D012684:Sensory Thresholds; D012737:Sex Factors; D015357:Vision Disparity / Q000502:physiology; D015348:Vision, Binocular / Q000235:genetics / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D014796:Visual Perception / Q000235:genetics / Q000502:physiology; D055815:Young Adult
keywords: Binocular rivalry; Dichoptic masking; GWAS; Individual differences; Stereo acuity; Stereopsis