title: Median effective effect-site concentration of sufentanil for wake-up test in adolescents undergoing surgery: a randomized trial.
abstract: BACKGROUND
  To determine the median effective concentration of sufentanil as an analgesic during wake-up tests after sevoflurane anesthesia during surgery for adolescent idiopathic scoliosis (AIS).
  
  
  METHODS
  This is a randomised controlled trial. Sixty patients aged 13-18 years scheduled for AIS surgery were randomized into six groups of 10 patients each to receive target effect-site concentrations of sufentanil of 0.19, 0.1809, 0.1723, 0.1641, 0.1563, and 0.1489 ng/ml (target concentration ratio, 1.05). Wake-up time was recorded. Median EC50 and 95% confidence interval (CI) for sufentanil target-controlled infusion (TCI) were determined using Kärber's method. The primary outcome was median EC50 for sufentanil TCI as an analgesic during the wake-up test after sevoflurane anesthesia during surgery for AIS.
  
  
  RESULTS
  The EC50 and 95% CI of sufentanil TCI were 0.1682 ng/ml and 0.1641 ~ 0.1724 ng/ml, respectively.
  
  
  CONCLUSIONS
  The EC50 of sufentanil TCI was 0.1682 ng/ml (95% CI: 0.1641 ~ 0.1724 ng/ml) during sevoflurane anesthesia in adolescents undergoing surgery for idiopathic scoliosis with intraoperative wake-up tests.
  
  
  BACKGROUND
  Clinicaltrials.gov identifier: ChiCTR-TTRCC-12002696.
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Cheng-Hua
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Wei-Qing
authors.initials: WQ
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Yun-Li
authors.initials: YL
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Fa-Tuan
authors.initials: FT
authors.lastname: Dong
authors.affiliation: Department of Anesthesiology, Kunming General Hospital of Chengdu Military Area, Kunming, 650032 China.
authors.forename: Zhang-Xiang
authors.initials: ZX
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology; D016343:Monitoring, Intraoperative; D012600:Scoliosis / Q000601:surgery; D000077149:Sevoflurane; D013119:Spinal Cord Injuries / Q000139:chemically induced / Q000517:prevention & control; D017409:Sufentanil / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D017409:Sufentanil
keywords: Idiopathic scoliosis; Intraoperative wake-up test; Sufentanil