title: Suplatast tosilate for treating cutaneous mastocytosis.
abstract: Pediatric cutaneous mastocytosis is a rare disease caused by mast cell hyperplasia. We report the case of an infant diagnosed as cutaneous mastocytosis and seasonal allergies. The wheals, flushing, and pruritus of the mastocytosis were unresponsive to combination therapy with an antihistamine, a mast cell stabilizer (sodium cromoglycate), and a leukotriene antagonist. Addition of suplatast tosilate as a treatment for the seasonal allergy also dramatically improved his cutaneous symptoms and signs. Further trials of suplatast tosilate in selected cases of cutaneous mastocytosis are warranted.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Tokyo University, Tokyo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yasudo
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Tokyo University, Tokyo, Japan.|Laboratory for Allergic Disease, RIKEN Center for Integrative Medical Sciences, Yokohama City, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ando
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Tokyo University, Tokyo, Japan.
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Hiwatari
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Tokyo University, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
mesh_terms: D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D001190:Arylsulfonates / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D034701:Mastocytosis, Cutaneous / Q000188:drug therapy*; D013452:Sulfonium Compounds / Q000627:therapeutic use*
chemical_list: D018926:Anti-Allergic Agents; D001190:Arylsulfonates; D013452:Sulfonium Compounds; C073028:suplatast tosilate