title: A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis.
abstract: This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log10 copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence on the viral clearance was observed.
authors.affiliation: Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control (CDC), Beijing, China. panyang10@gmail.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Pan
authors.forename: Weixian
authors.initials: W
authors.lastname: Shi
authors.forename: Peng
authors.initials: P
authors.lastname: Yang
authors.forename: Shuangsheng
authors.initials: S
authors.lastname: Wu
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Peng
authors.forename: Shujuan
authors.initials: S
authors.lastname: Cui
authors.forename: Daitao
authors.initials: D
authors.lastname: Zhang
authors.forename: Guilan
authors.initials: G
authors.lastname: Lu
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zhao
authors.forename: Yimeng
authors.initials: Y
authors.lastname: Liu
authors.forename: Quanyi
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use; D002681:China; D024882:Drug Resistance, Viral; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis* / Q000628:therapy / Q000821:virology*; D008875:Middle Aged; D020125:Mutation, Missense; D013995:Time; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents