title: Association of PTPN22 polymorphsims and ankylosing spondylitis susceptibility.
abstract: BACKGROUND
  As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility.
  
  
  METHODS
  We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 AS patients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method.
  
  
  RESULTS
  The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011).
  
  
  CONCLUSIONS
  Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Qingxi
authors.initials: Q
authors.lastname: Meng
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Wang
authors.affiliation: The First Veteran Institute of Jinan Military Region Jinan, Shandong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yu
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Qunqun
authors.initials: Q
authors.lastname: Shan
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Zhaohu
authors.initials: Z
authors.lastname: Mao
authors.affiliation: Department of Spinal Cord Injury, Institute of Orthopedics and Traumatology of Chinese PLA, General Hospital of Jinan Military Area Command Jinan, Shandong, China.
authors.forename: Tingbao
authors.initials: T
authors.lastname: Zhao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics*; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000235:genetics*
chemical_list: C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22
keywords: AS; PTPN22; polymorphism; susceptibility