title: Peptide-DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun.
abstract: We describe a ds-oligonucleotide-peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.
authors.affiliation: Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, C/Jenaro de la Fuente s/n, Campus Vida, 15782 Santiago de Compostela, Spain. joseluis.mascarenas@usc.es.
authors.forename: Elena
authors.initials: E
authors.lastname: Pazos
authors.forename: Cecilia
authors.initials: C
authors.lastname: Portela
authors.forename: Cristina
authors.initials: C
authors.lastname: Penas
authors.forename: M Eugenio
authors.initials: ME
authors.lastname: Vázquez
authors.forename: José L
authors.initials: JL
authors.lastname: Mascareñas
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D024202:Electrophoretic Mobility Shift Assay; D005454:Fluorescence Polarization; D008969:Molecular Sequence Data; D009841:Oligonucleotides; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D016755:Proto-Oncogene Proteins c-jun / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009841:Oligonucleotides; D010455:Peptides; D016755:Proto-Oncogene Proteins c-jun; D004247:DNA