title: Hypoxia as a cause of treatment failure in non-small cell carcinoma of the lung.
abstract: Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic factor in non-small cell lung cancer. The negative effect of low oxygenation on radiation therapy effect has been known for decades, but more recent research has emphasized that hypoxia also has a profound effect on a tumor's aggression and metastatic propensity. In this review, current knowledge on both these aspects of treatment failure in NSCLC due to hypoxia has been discussed, along with a presentation of modern methods for hypoxia measurement and current therapeutical interventions to circumvent the negative effect of hypoxia on treatment results.
authors.affiliation: Department of Oncology, Oslo University Hospital-The Norwegian Radium Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: otr@ous-hf.no.
authors.forename: Odd Terje
authors.initials: OT
authors.lastname: Brustugun
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D015687:Cell Hypoxia; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D017211:Treatment Failure