title: The association between thoracic periaortic fat and major adverse cardiovascular events.
abstract: OBJECTIVE
  The study aimed to examine the association between thoracic periaortic fat tissue volume and the long-term incidence of major adverse cardiovascular events.
  
  
  METHODS
  This retrospective cohort study included 433 consecutive patients (372 male and 61 female). Periaortic fat tissue volume was measured via electrocardiogram-gated 64-multidetector computed tomography. The patients were evaluated on an average 3 years of follow-up for major adverse cardiovascular events. The patients were divided into groups according to the presence of major adverse cardiovascular events.
  
  
  RESULTS
  Major adverse cardiovascular events were noted in 44 (10.2 %) patients during follow-up. Periaortic fat tissue volume was significantly higher in the major adverse cardiovascular events (+) group (35.4 ± 26.1 cm(3) vs. 24.1 ± 14.9 cm(3), P = 0.001). The logistic regression model showed that periaortic fat tissue volume (hazard ratio: 1.03; 95 % CI: 1.01-1.05; P = 0.001), the glomerular filtration rate (hazard ratio: 0.98; 95 % CI: 0.96-0.99; P = 0.03), and male gender (hazard ratio: 4.76; 95 % CI: 1.08-20.90; P = 0.04) were independent predictors of major adverse cardiovascular events.
  
  
  CONCLUSIONS
  Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.
authors.affiliation: Department of Cardiology, Mevlana University, Yeni İstanbul Cad. No: 235, 42003, Selçuklu, Konya, Turkey, zeynettinkaya@yahoo.com.
authors.forename: Zeynettin
authors.initials: Z
authors.lastname: Kaya
authors.forename: Seref
authors.initials: S
authors.lastname: Ulucan
authors.lastname: MehmetKayrak
authors.forename: Omer
authors.initials: O
authors.lastname: Akyurek
authors.forename: Huseyin
authors.initials: H
authors.lastname: Katlandur
authors.forename: Ahmet
authors.initials: A
authors.lastname: Keser
authors.forename: Duran
authors.initials: D
authors.lastname: Efe
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ozdil
authors.forename: Mehmet S
authors.initials: MS
authors.lastname: Ulgen
mesh_terms: D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000401:mortality*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology