title: [Epigenetic dysregulation in myelodysplastic syndrome].
abstract: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease characterized by impaired hematopoiesis and an increased risk of transformation to acute myeloid leukemia. Various epigenetic regulators are mutated in MDS patients, indicating that accumulation of epigenetic alterations together with genetic alterations plays a crucial role in the development of MDS.
authors.affiliation: Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University.
authors.forename: Goro
authors.initials: G
authors.lastname: Sashida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iwama
mesh_terms: D044127:Epigenesis, Genetic / Q000235:genetics*; D057890:Epigenomics; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics*