title: Role of genetics in lung transplant complications.
abstract: There is increasing knowledge that patients can be predisposed to a certain disease by genetic variations in their DNA. Extensive genetic variation has been described in molecules involved in short- and long-term complications after lung transplantation (LTx), such as primary graft dysfunction (PGD), acute rejection, respiratory infection, chronic lung allograft dysfunction (CLAD), and mortality. Several of these studies could not be confirmed or were not reproduced in other cohorts. However, large multicenter prospective studies need to be performed to define the real clinical consequence and significance of genotyping the donor and receptor of a LTx. The current review presents an overview of genetic polymorphisms (SNP) investigating an association with different complications after LTx. Finally, the major drawbacks, clinical relevance, and future perspectives will be discussed.
authors.affiliation: KU Leuven, and UZ Leuven, Department of Clinical and Experimental Medicine, Laboratory of Pneumology, Lung Transplant Unit , Leuven , Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Ruttens
authors.forename: E
authors.initials: E
authors.lastname: Vandermeulen
authors.forename: S E
authors.initials: SE
authors.lastname: Verleden
authors.forename: H
authors.initials: H
authors.lastname: Bellon
authors.forename: R
authors.initials: R
authors.lastname: Vos
authors.forename: D E
authors.initials: DE
authors.lastname: Van Raemdonck
authors.forename: L J
authors.initials: LJ
authors.lastname: Dupont
authors.forename: B M
authors.initials: BM
authors.lastname: Vanaudenaerde
authors.forename: G M
authors.initials: GM
authors.lastname: Verleden
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D008171:Lung Diseases / Q000235:genetics* / Q000601:surgery*; D016040:Lung Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055031:Primary Graft Dysfunction / Q000235:genetics*; D014019:Tissue Donors; D014184:Transplantation, Homologous
keywords: Acute rejection; chronic lung allograft dysfunction; chronic rejection; lung transplantation; mortality; outcome; primary graft dysfunction; single nucleotide polymorphisms