title: Histiocytoid giant cellulitis-like Sweet's syndrome: case report and review of the literature.
abstract: BACKGROUND
  Histiocytoid Sweet syndrome is an uncommon variant in which the dermal infiltrate is composed of mononuclear cells with a histiocytic appearance that represent immature myeloid cells. Giant cellulitis-like Sweet syndrome is a recently described variant characterized by relapsing widespread giant lesions.
  
  
  OBJECTIVE
  We report a unique patient with histiocytoid giant cellulitis-like Sweet syndrome and review the current literature on histiocytoid Sweet syndrome and giant cellulitis-like Sweet syndrome.
  
  
  METHODS
  We reviewed PubMed for the following terms and have reviewed the literature: histiocytoid, giant cellulitis-like, and Sweet syndrome.
  
  
  RESULTS
  Six individuals, including our patient, have been reported with giant cellulitis-like Sweet syndrome; four had obesity, two had a hematologic malignancy, and one had breast cancer. Histiocytoid Sweet syndrome has been reported in association with autoimmune diseases, infection or inflammation, inflammatory bowel disease, malignancies, medications, and other conditions.
  
  
  CONCLUSIONS
  Histiocytoid Sweet syndrome is a rare variant of Sweet syndrome, often associated with malignancy. Giant cellulitis-like Sweet syndrome has been reported in six individuals; four of the patients were obese and three of the patients had an associated cancer. Our patient had histiocytoid giant cellulitis-like Sweet syndrome-associated myelodysplastic syndrome/myeloproliferative disorder. The diagnosis of histiocytoid Sweet syndrome or giant cellulitis-like Sweet syndrome should prompt the clinician to consider additional evaluation for a Sweet syndrome-associated malignancy.
authors.forename: Jessica Kim
authors.initials: JK
authors.lastname: So
authors.forename: Casey A
authors.initials: CA
authors.lastname: Carlos
authors.forename: Corey S
authors.initials: CS
authors.lastname: Frucht
authors.affiliation: UC San Diego - Dermatology.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Cohen
mesh_terms: D000368:Aged; D002481:Cellulitis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D054437:Myelodysplastic-Myeloproliferative Diseases / Q000150:complications; D016463:Sweet Syndrome / Q000150:complications / Q000473:pathology*; D013848:Thigh / Q000473:pathology