title: Effect of weight reduction on the severity of lower urinary tract symptoms in obese male patients with benign prostatic hyperplasia: a randomized controlled trial.
abstract: OBJECTIVE
  We assessed whether weight reduction is an effective intervention for the management of lower urinary tract symptoms (LUTS) and investigated the relationship between obesity and LUTS.
  
  
  METHODS
  This was a prospective randomized controlled trial that enrolled obese men older than 50 years with LUTS. The study period was 52 weeks. All patients received standardized alpha-adrenergic blocker therapy for the treatment of benign prostatic hyperplasia (BPH) during the run-in period. Patients were randomized to receive either a standardized prerecorded video program on the general principle of weight reduction or a comprehensive weight reduction program. Patients were assessed at different time points with symptom assessment, uroflowmetry, transrectal ultrasound, and metabolic assessment.
  
  
  RESULTS
  Sixty-five patients were allocated to each study arm. After the study period, no significant difference in weight reduction was found between the two arms. When the pre- and postintervention parameters were compared, none were statistically different between the 2 arms, namely nocturia, International Prostate Symptom Score, quality of life assessment, and uroflowmetry parameters. When the whole study population was taken as a single cohort, these parameters were also not significantly different between the group with a body mass index of 25 to <30 kg/m(2) and the group with a BMI of 30 to 35 kg/m(2).
  
  
  CONCLUSIONS
  We found no association between obesity and LUTS. This could have been due to the less marked weight difference in our cohort. Whereas weight reduction may be an effective measure to improve LUTS, the implementation of a successful program remains a challenge.
authors.affiliation: Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. ; Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Chi-Hang
authors.initials: CH
authors.lastname: Yee
authors.affiliation: Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Wing-Yee
authors.initials: WY
authors.lastname: So
authors.affiliation: Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Sidney K H
authors.initials: SK
authors.lastname: Yip
authors.affiliation: Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Edwin
authors.initials: E
authors.lastname: Wu
authors.affiliation: Department of Surgery, Prince of Wales Hospital, Hong Kong, China.
authors.forename: Phyllis
authors.initials: P
authors.lastname: Yau
authors.affiliation: Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Chi-Fai
authors.initials: CF
authors.lastname: Ng
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000368:Aged; D015992:Body Mass Index; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000175:diagnosis / Q000188:drug therapy*; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D000317:Adrenergic alpha-Antagonists
keywords: Exercise; Lower urinary tract symptoms; Obesity