title: Peritoneal carcinomatosis: intraoperative parameters in open (coliseum) versus closed abdomen HIPEC.
abstract: BACKGROUND
  Peritoneal carcinomatosis (PC) is associated with a poor prognosis. Cytoreductive surgery (CRS) and HIPEC play an important role in well-selected patients with PC. The aim of the study is to present the differences in the intraoperative parameters in patients who received HIPEC in two different manners, open versus closed abdomen.
  
  
  METHODS
  The population includes 105 patients with peritoneal carcinomatosis from colorectal, gastric, and ovarian cancer, sarcoma, mesothelioma, and pseudomyxoma peritonei. Group A (n = 60) received HIPEC using the open technique and Group B (n = 45) received HIPEC with the closed technique. The main end points were morbidity, mortality, and overall hospital stay.
  
  
  RESULTS
  There were two postoperative deaths (3.3%) in the open group versus no deaths in the closed group. Twenty-two patients in the open group (55%) had grade III-IV complications versus 18 patients in the closed group (40%). There are more stable intraoperative conditions in the closed abdomen HIPEC in CVP, pulse rate, and systolic pressure parameters.
  
  
  CONCLUSIONS
  Both methods are equal in the HIPEC procedures. Perhaps the closed method is the method of choice for frail patients due to more stable hemodynamic parameters.
authors.affiliation: 1st Department of Surgical Oncology, Metaxa Cancer Hospital, 18537 Piraeus, Greece ; Peritoneal Surface Malignancy Unit, IASO General Hospital, 15562 Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Halkia
authors.affiliation: 1st Department of Surgical Oncology, Metaxa Cancer Hospital, 18537 Piraeus, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Tsochrinis
authors.affiliation: 1st Department of Surgical Oncology, Metaxa Cancer Hospital, 18537 Piraeus, Greece.
authors.forename: D T
authors.initials: DT
authors.lastname: Vassiliadou
authors.affiliation: Department of Anesthesiology, Metaxa Cancer Hospital, 18537 Piraeus, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Pavlakou
authors.affiliation: Department of Anesthesiology, Gennimatas General Hospital, 54635 Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Vaxevanidou
authors.affiliation: Department of Surgery, General Hospital of Messolonghi, 30200 Messolonghi, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Datsis
authors.affiliation: 1st Department of Surgical Oncology, Metaxa Cancer Hospital, 18537 Piraeus, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Efstathiou
authors.affiliation: 1st Department of Surgical Oncology, Metaxa Cancer Hospital, 18537 Piraeus, Greece.
authors.forename: J
authors.initials: J
authors.lastname: Spiliotis
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D003131:Combined Modality Therapy; D065426:Cytoreduction Surgical Procedures; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents