title: Pathology of melanoma.
abstract: The pathology of melanoma is discussed in relation to surgical diagnosis and management. Pitfalls that may result in problems of clinicopathologic communication are emphasized. A compelling vision for the future is that all tumors will be characterized by their driving oncogenes, suppressor genes, and other genomic factors. The success of targeted therapy directed against individual oncogenes, despite its limitations, suggests that a repertoire of targeted agents will be developed that can be used against a variety of different tumors, depending on the results of genetic testing. Nevertheless, histopathologic diagnosis and surgical therapy will remain mainstays of management for melanoma.
authors.affiliation: Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: David.Elder@uphs.upenn.edu.
authors.forename: David E
authors.initials: DE
authors.lastname: Elder
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D008545:Melanoma / Q000145:classification / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Classification; Diagnosis; Histopathology; Melanoma; Prognosis