title: Physicochemical and tablet properties of Cyperus alulatus rhizomes starch granules.
abstract: The starch extracted from rhizomes of Cyperus alulatus (CA) was characterized for its physicochemical, morphological and tableting properties. Rhizomes of CA yield a significant quantity of starch granules (CASG) i.e., 11.93%. CASG was characterized in terms of moisture, ash and amylose contents, solubility and swelling power, paste clarity and water retention capacity. The swelling power was found to be significantly improved with the increase in temperature. Scanning electron micrographs revealed that the granule's surface was smooth, the granules were spherical, mostly round, disc like, and the size range was 6.65-12.13 μm. Finger print region in FTIR spectra confirmed its carbohydrate nature. The evaluated micromeritic properties of extracted granule's bulk density, tapped density, Carr's index, Hausner ratio, true density and porosity render unique practicability of CASG being used as an adjuvant in pharmaceutical solid dosage forms. Tablets prepared by using CASG showed higher mechanical strength and more disintegration time, which depicted the characteristic binding nature of the starch granules. As CASG is imparting better binding properties in less concentration and also it can be used in combination with the established starches to get the synergistic effect; this starch can be used commercially in the tablet preparation.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.
authors.forename: N
authors.initials: N
authors.lastname: Paramakrishnan
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.
authors.forename: S
authors.initials: S
authors.lastname: Jha
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India. Electronic address: jayarampharm@gmail.com.
authors.forename: K Jayaram
authors.initials: KJ
authors.lastname: Kumar
mesh_terms: D002626:Chemistry, Pharmaceutical; D029786:Cyperus / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016062:Porosity; D027343:Rhizome / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry* / Q000648:ultrastructure; D013607:Tablets / Q000737:chemistry*; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D013607:Tablets; D014867:Water; D013213:Starch
keywords: Cyperus alulatus; Rhizome; Starch; Tablet properties