title: MicroRNA responses to environmental liver carcinogens: Biological and clinical significance.
abstract: A large number of biological, chemical, and dietary factors have been implicated in the development of liver cancer. These involve complex and protracted interactions between genetic, epigenetic, and environmental factors. The survival rate for patients diagnosed with late-stage liver cancer is currently low due to the aggressive nature of the disease and resistance to therapy. An increasing body of evidence has offered support for the crucial role of non-coding microRNA (miRNA) in directing hepatic responses to environmental risk factors for liver cancer. In this review we focus on miRNA responses to environmental liver cancer risk factors and their potential biological and clinical significance.
authors.affiliation: Department of Life and Health Sciences, University of Nicosia, Cyprus; Center for the study of Haematological Malignancies, Nicosia, Cyprus.
authors.forename: Vicky
authors.initials: V
authors.lastname: Nicolaidou
authors.affiliation: Department of Cytogenetics and Genomic, Cyprus Institute of Neurology and Genetics, Cyprus. Electronic address: costask@cing.ac.cy.
authors.forename: Costas
authors.initials: C
authors.lastname: Koufaris
mesh_terms: D000348:Aflatoxins / Q000633:toxicity; D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism; D005234:Fatty Liver / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012307:Risk Factors; D012377:Rodentia
chemical_list: D000348:Aflatoxins; D002274:Carcinogens, Environmental; D035683:MicroRNAs; D011084:Polycyclic Aromatic Hydrocarbons; D015254:DNA Modification Methylases
keywords: Aflatoxin; Alcohol; Carcinogen; Circulating; Hepatitis; Obesity