title: Association between the oxytocin receptor gene polymorphism (rs53576) and bulimia nervosa.
abstract: OBJECTIVE
  Oxytocin circuits are implicated in the regulation of appetite and weight. Variants in the oxytocin receptor (OXTR) gene have been associated with bulimic behaviour. This study aimed to investigate the association between the OXTR gene and eating disorders.
  
  
  METHODS
  We genotyped six single nucleotide polymorphisms, rs53576, rs237879, rs2228485, rs13316193, rs2254298 and rs1042778, located within the OXTR gene in Korean patients with eating disorders using the single-base extension method. We studied a total of 262 women, including 69 patients with anorexia nervosa, 90 patients with bulimia nervosa (BN), and 103 healthy women.
  
  
  RESULTS
  We found a positive association between the G allele of OXTR rs53576 and BN. In the BN group, the G carriers showed a high score on the behavioural inhibition system.
  
  
  CONCLUSIONS
  These findings suggest the involvement of the oxytocinergic system in the mechanism that underlies BN.
authors.affiliation: Department of Neuropsychiatry, Seoul Paik Hospital, Inje University College of Medicine, Seoul, South Korea; Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea.
authors.forename: Youl-Ri
authors.initials: YR
authors.lastname: Kim
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Chan-Hyung
authors.initials: CH
authors.lastname: Kim
authors.forename: Jae Gook
authors.initials: JG
authors.lastname: Shin
authors.forename: Janet
authors.initials: J
authors.lastname: Treasure
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics*; D001835:Body Weight; D052018:Bulimia Nervosa / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010121:Oxytocin / Q000502:physiology; D020641:Polymorphism, Single Nucleotide; D018045:Receptors, Oxytocin / Q000235:genetics*; D055815:Young Adult
chemical_list: D018045:Receptors, Oxytocin; D010121:Oxytocin
keywords: OXTR; allele; anorexia nervosa; behavioural activation system; behavioural inhibition system; bulimia nervosa; eating disorders; genotype; oxytocin; rs1042778; rs13316193; rs2228485; rs2254298; rs237879; rs53576