title: PLEKHA5: A Key to Unlock the Blood-Brain Barrier?
abstract: Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
authors.affiliation: Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Sylvia C
authors.initials: SC
authors.lastname: Eisele
authors.affiliation: Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Corey M
authors.initials: CM
authors.lastname: Gill
authors.affiliation: Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Shankar
authors.affiliation: Division of Neuro-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. pbrastianos@mgh.harvard.edu.
authors.forename: Priscilla K
authors.initials: PK
authors.lastname: Brastianos
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000556:secondary*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000556:secondary*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins