title: Ipsilateral reduced olfactory bulb volume in patients with unilateral nasal obstruction.
abstract: OBJECTIVE
  To evaluate the effect of unilateral nasal obstruction (by nasal polyps of different histopathology) on olfactory bulb volume using MRI technique.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Tertiary university hospitals, Departments of Otolaryngology and Radiology.
  
  
  METHODS
  Eleven patients with a few months of complete unilateral nasal obstruction of different pathological etiologies were selected. MRI assessment of olfactory bulb volume was performed using planimetric manual contouring. The contralateral olfactory bulb was used as a comparative control for the same patient. Eleven healthy controls constituted the control group.
  
  
  RESULTS
  Mean olfactory bulb volume ± SD of obstructed side = 14.3 ± 3.7 mm(3), mean olfactory bulb volume ± SD of nonobstructed side = 43.49 ± 10.7 mm(3). The difference between the 2 sides was significant (P = .003). The difference in olfactory bulb volume between normal subjects and nonobstructed nasal side was statistically nonsignificant (t = .9118, P = .3727), while the difference between normal subjects' olfactory bulb volume and obstructed nasal side olfactory bulb volume in our patients was extremely statistically significant (t = 9.7320, P < .0001). A strong negative correlation was found between duration of obstruction and olfactory bulb volume (R = -0.9761).
  
  
  CONCLUSIONS
  This study shows that unilateral nasal obstruction may be associated with a lateralized ipsilateral difference of olfactory bulb volume.
authors.affiliation: Zagazig University, Zagazig, Egypt askr_sh@yahoo.com.
authors.forename: Sherif M
authors.initials: SM
authors.lastname: Askar
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Ismail S
authors.initials: IS
authors.lastname: Elnashar
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Mohammad W
authors.initials: MW
authors.lastname: El-Anwar
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Hazem S
authors.initials: HS
authors.lastname: Amer
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: El Shawadfy
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Sameh M
authors.initials: SM
authors.lastname: Hosny
authors.affiliation: Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Bazeed
authors.affiliation: Zagazig University, Zagazig, Egypt.
authors.forename: Ayman F
authors.initials: AF
authors.lastname: Ahmed
authors.affiliation: Mansoura University, Mansoura, Egypt.
authors.forename: Mona A
authors.initials: MA
authors.lastname: Ghanem
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000209:etiology / Q000473:pathology*; D009298:Nasal Polyps / Q000150:complications; D009830:Olfactory Bulb / Q000473:pathology*; D009929:Organ Size; D055815:Young Adult
keywords: olfaction; olfactory bulb; planimetric manual contouring; unilateral nasal obstruction