title: Evolution of aortic wall thickness and stiffness with atherosclerosis: long-term follow up from the multi-ethnic study of atherosclerosis.
abstract: The study was performed to determine age, sex, and time-dependent changes in aortic wall thickness (AWT) and to evaluate cross-sectional associations between AWT and arterial stiffness in older adults. Three hundred seventy-one longitudinal and 426 cross-sectional measurements of AWT from cardiovascular magnetic resonance imaging studies conducted within the Multi-Ethnic Study of Atherosclerosis were analyzed at 2 points in time, in 2000 to 2002 and then again from follow-up examinations in 2010 to 2012. Aortic wall thickness was determined from a double inversion recovery black-blood fast spin-echo sequence, and aortic stiffness was measured from a phase-contrast cine gradient echo sequence. The thickness of the midthoracic descending aortic wall was measured and correlated to distensibility of the ascending aorta and aortic pulse wave velocity. The average rate of AWT change was 0.032 mm/y. The increase in AWT was greater for those aged 45 to 54 years relative to individuals older than 55 years (P trend<0.001). Ascending aortic distensibility was lower (P<0.001) and pulse wave velocity was higher (P=0.012) for hypertensive subjects. After adjustment for traditional risk factors, distensibility of the ascending aorta was significantly related to AWT in participants without hypertension. Hypertension was associated with increased aortic stiffness independent of aortic wall thickness.
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Liu
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Doris
authors.initials: D
authors.lastname: Chen
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: David A
authors.initials: DA
authors.lastname: Bluemke
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Colin O
authors.initials: CO
authors.lastname: Wu
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Gisela
authors.initials: G
authors.lastname: Teixido-Tura
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Atul
authors.initials: A
authors.lastname: Chugh
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: Sujethra
authors.initials: S
authors.lastname: Vasu
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.).
authors.forename: João A C
authors.initials: JA
authors.lastname: Lima
authors.affiliation: From the Department of Radiology and Imaging Sciences, National Institutes of Health (NIH), Bethesda, MD (C.-Y.L., D.A.B.); Department of Radiology, Johns Hopkins Hospital, Baltimore, MD (D.C., D.A.B., J.A.C.L.); Office of Biostatistics Research, National Heart, Lung, and Blood Institutes (NHLBI), Bethesda, MD (C.O.W.); Department of Cardiology, Hospital General Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (G.T.-T.); Division of Cardiovascular Medicine, University of Louisville School of Medicine, KY (A.C.); and Division of Cardiovascular Medicine, Department of Internal Medicine, Wake Forest University, Winston-Salem, NC (S.V., W.G.H.). ghundley@wakehealth.edu.
authors.forename: W Gregory
authors.initials: WG
authors.lastname: Hundley
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001013:Aorta, Thoracic / Q000473:pathology / Q000503:physiopathology*; D001018:Aortic Diseases / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D050197:Atherosclerosis / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D063177:Pulse Wave Analysis; D012189:Retrospective Studies; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D059289:Vascular Stiffness / Q000502:physiology*
keywords: hypertension; magnetic resonance imaging; vascular stiffness