title: Study of the effect of altitude on the measurement of glycated haemoglobin using point-of-care instruments.
abstract: We measured the glycated haemoglobin (HbA1c) levels of a total of 24 non-diabetic volunteers and diabetic patients using a point-of-care (POC) analyser in three Cameroonian cities at different altitudes. Although 12 to 25% of duplicates had more than 0.5% (8 mmol/mol) difference across the sites, HbA1c values correlated significantly (r = 0.89-0.96). Further calibration studies against gold-standard measures are warranted.
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Sandra W
authors.initials: SW
authors.lastname: Veigne
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Molecular Medicine and Metabolism Laboratories, Bio-technology Center, University of Yaoundé 1, Yaoundé, Cameroon. sobngwieugene@yahoo.fr.
authors.forename: Eugene
authors.initials: E
authors.lastname: Sobngwi
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Department of Medicine, McGill University, Montreal, Quebec, Canada.
authors.forename: Brice E
authors.initials: BE
authors.lastname: Nouthe
authors.affiliation: Centre of Higher Education in Health Sciences, Catholic University of Central Africa, Yaoundé, Cameroon.
authors.forename: Joelle
authors.initials: J
authors.lastname: Sobngwi-Tambekou
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University-VUB, Brussels, Belgium.
authors.forename: Eric V
authors.initials: EV
authors.lastname: Balti
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Serge
authors.initials: S
authors.lastname: Limen
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Mesmin Y
authors.initials: MY
authors.lastname: Dehayem
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Vicky
authors.initials: V
authors.lastname: Ama
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
authors.forename: Jean- Louis
authors.initials: J
authors.lastname: Nguewa
authors.affiliation: Cheick Anta Diop University, Dakar, Senegal.
authors.forename: Maimouna
authors.initials: M
authors.lastname: Ndour-Mbaye
authors.affiliation: University Teaching Hospital of Donka, Conakry, Guinea.
authors.forename: Alioune
authors.initials: A
authors.lastname: Camara
authors.affiliation: University Teaching Hospital of Donka, Conakry, Guinea.
authors.forename: Naby M
authors.initials: NM
authors.lastname: Balde
authors.affiliation: National Obesity Center, Yaoundé Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Molecular Medicine and Metabolism Laboratories, Bio-technology Center, University of Yaoundé 1, Yaoundé, Cameroon; University of Technology, Kingston, Jamaica.
authors.forename: Jean- Claude
authors.initials: J
authors.lastname: Mbanya
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D015415:Biomarkers / Q000097:blood; D002163:Cameroon; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D004867:Equipment Design; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019095:Point-of-Care Systems / Q000592:standards; D000067716:Point-of-Care Testing / Q000592:standards; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human