title: Cerebral Venous Sinus Thrombosis: Clinical Characteristics and Factors Influencing Clinical Outcome.
abstract: The frequency of patients diagnosed with cerebral venous sinus thrombosis (CVST) has increased due to the expanded use of noninvasive brain imaging methods. The aim of this study was to assess the correlations between the location and extent of venous sinus impairment, clinical presentation during the acute phase, recanalization, the presence of parenchymal lesions, and clinical outcome after 3 to 4 months in patients with CVST. In a retrospective study, clinical and magnetic resonance imaging data from a cohort of 51 consecutive patients with CVST (mean age 33.1 ± 15.4 years) were collected and analyzed. Good clinical outcome after 3 to 4 months, which was assessed using the modified Rankin scale, significantly negatively correlated with a thrombosis location in the left transverse, left sigmoid, or superior sagittal sinus (P = .022, P = .045, and P = .046, respectively) and positively correlated with recanalization (P = .048). The clinical outcome was significantly more favorable in the females with gender-specific risk factors than in the males (P = .029). In conclusion, successful recanalization substantially helps to achieve good clinical outcome in patients with CVST.
authors.affiliation: Department of Neurology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic.
authors.forename: Dagmar
authors.initials: D
authors.lastname: Krajíčková
authors.affiliation: Department of Radiology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic.
authors.forename: Ludovít
authors.initials: L
authors.lastname: Klzo
authors.affiliation: Department of Radiology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic.
authors.forename: Antonín
authors.initials: A
authors.lastname: Krajina
authors.affiliation: Department of Neurology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic.
authors.forename: Oldřich
authors.initials: O
authors.lastname: Vyšata
authors.affiliation: Department of Neurology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Herzig
authors.affiliation: Department of Neurology, Comprehensive Stroke Center, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital in Hradec Králové, Czech Republic valismar@seznam.cz.
authors.forename: Martin
authors.initials: M
authors.lastname: Vališ
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis; D016896:Treatment Outcome
keywords: cerebral venous sinus thrombosis; clinical outcome; gender-specific risk factors; parenchymal lesion; recanalization