title: Universality in the morphology and mechanics of coarsening amyloid fibril networks.
abstract: Peptide hydrogels have important applications as biomaterials and in nanotechnology, but utilization often depends on their mechanical properties for which we currently have no predictive capability. Here we use a peptide model to simulate the formation of percolating amyloid fibril networks and couple these to the elastic network theory to determine their mechanical properties. We find that the time variation of network length scales can be collapsed onto master curves by using a time scaling function that depends on the peptide interaction anisotropy. The same scaling applies to network mechanics, revealing a nonmonotonic dependence of the shear modulus with time. Our structure-function relationship between the peptide building blocks, network morphology, and network mechanical properties can aid in the design of amyloid fibril networks with tailored mechanical properties.
authors.affiliation: School of Chemistry, University of Leeds, LS2 9JT Leeds, United Kingdom.
authors.forename: L G
authors.initials: LG
authors.lastname: Rizzi
authors.affiliation: School of Computing, University of Leeds, LS2 9JT Leeds, United Kingdom.
authors.forename: D A
authors.initials: DA
authors.lastname: Head
authors.affiliation: School of Chemistry, University of Leeds, LS2 9JT Leeds, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Auer