title: Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin.
abstract: Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with a commercial antibiotic streptomycin. Phytol was a compound identified in all extracts by GC/MS, being majoritary component in Plectranthus barbatus and Rosmarinus officinalis. The Gram-positive bacteria were more sensitive to ethanol extracts, and Plectranthus barbatus and Rosmarinus officinalis were the most active extracts. Ethanol extracts exhibited a synergetic effect with streptomycin. These results encourage additional studies, in order to evaluate the possibilities of using ethanol extracts of Lamiaceae family as natural source for antibacterial activity.
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Sthéfane G
authors.initials: SG
authors.lastname: Araújo
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Lucas F
authors.initials: LF
authors.lastname: Alves
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Maria Eduarda A
authors.initials: ME
authors.lastname: Pinto
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Graziela T
authors.initials: GT
authors.lastname: Oliveira
authors.affiliation: Laboratório de Química de Produtos Naturais Centro de Pesquisas René Rachou Fiocruz, Belo HorizonteMG Brazil Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fiocruz, Belo Horizonte, MG, Brazil.
authors.forename: Ezequias P
authors.initials: EP
authors.lastname: Siqueira
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Rosy I M A
authors.initials: RI
authors.lastname: Ribeiro
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Jaqueline M S
authors.initials: JM
authors.lastname: Ferreira
authors.affiliation: Universidade Federal de São João del-Rei Campus Centro-Oeste Dona Lindu, DivinópolisMG Brazil Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.
authors.forename: Luciana A R S
authors.initials: LA
authors.lastname: Lima
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004357:Drug Synergism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D013307:Streptomycin / Q000494:pharmacology*; D055549:Volatile Organic Compounds / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D055549:Volatile Organic Compounds; D013307:Streptomycin
keywords: Lamiaceae; antibacterial; ethanol extracts; streptomycin; volatile compounds