title: Ionotropic Cross-linked Carbo-protein Micro Matrix System: An Approach for Improvement of Drug Release, Compaction and Tableting behavior of Losartan Potassium.
abstract: The aim of the present research work is to develop carbo-protein polymeric complex based sustain release microspheres of losartan potassium and investigate the ability of this dosage form to improve the flowability, compressibility and tableting properties of losartan potassium. The influence of silk sericin, alginate and its blend on various physicochemical parameters and in vitro drug release pattern were studied to optimize the concentration of polymeric blend required for 12 h. sustain release. Optimized batch was subjected to different flowability, compressibility and tableting properties studies to observe the effects of carbo-protein microspheres on flow properties. Results indicated that the concentration of sericin was found to be the main influential factor for prolonged drug release. Different micromeritic studies revealed that the poor flowability and compressibility properties of pure losartan potassium were significantly improved by this algino-sericin microspheric dosage form. Research findings also revealed that plasticity, die filling behavior and tableting properties of the pure drug were significantly improved by this microsphere formulation. So these prospective results concluded that carbo-protein polymeric microspheres helps to sustain the drug release for prolong hours as well as improve the flowability, compressibility and tableting properties of losartan potassium.
authors.affiliation: P.G. Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur-760002, Odisha, India. madhusmruti_K@rediffmail.com.
authors.forename: Madhusmruti
authors.initials: M
authors.lastname: Khandai
authors.forename: Santanu
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Ashoke Kumar
authors.initials: AK
authors.lastname: Ghosh
mesh_terms: D000464:Alginates / Q000737:chemistry*; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D019808:Losartan / Q000008:administration & dosage* / Q000032:analysis / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D047030:Sericins / Q000737:chemistry*; D013499:Surface Properties; D013607:Tablets; D013997:Time Factors
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D047030:Sericins; D013607:Tablets; D020723:Glucuronic Acid; D019808:Losartan