title: Meta-analysis of studies on breast cancer risk and diet in Chinese women.
abstract: OBJECTIVE
  A meta-analysis was carried out to summarize published data on the relationship between breast cancer and dietary factors.
  
  
  METHODS
  Databases in Chinese (China National Knowledge Infrastructure [CNKI], China Biology Medicine [CBM], WanFang, VIP) and in English (PubMed and Web of Science) were searched for articles analyzing vegetable, fruit, soy food and fat consumption and breast cancer risk published through June 30, 2013. Random effects models were used to estimate summary odds ratios (OR) based on high versus low intake, and subgroup analysis was conducted according to region, study design, paper quality and adjustment for confounding factors to detect the potential source of heterogeneity. Every study was screened according to the inclusion criteria and exclusion criteria, evaluated in accordance with the Newcastle-Ottawa Scale. RevMan 5.2 software was used for analysis.
  
  
  RESULTS
  Of 785 studies retrieved, 22 met inclusion criteria (13 in Chinese and 9 in English), representing 23,201 patients: 10,566 in the experimental group and 12,635 in the control group. Thirteen included studies showed vegetables consumption to be a relevant factor in breast cancer risk, OR = 0.77 (95% CI [confidence interval] 0.62-0.96). Eleven studies showed fruits consumption to be relevant, OR = 0.68 (95% CI 0.49-0.93). Significant differences were also found between those who consumed soy foods, OR = 0.68 (95% CI 0.50-0.93) and those who ate a high-fat diet, OR = 1.15 (95% CI 1.01-1.30).
  
  
  CONCLUSIONS
  This analysis confirms the association between intake of vegetables, fruits, soy foods and fat and the risk of breast cancer from published sources. It's suggested that high consumption of vegetables, fruits and soy foods may reduce the risk of breast cancer, while increasing fat consumption may increase the risk.
authors.affiliation: Chinese General Hospital of The Air Force Beijing 100142, China ; Anhui Medical University Hefei 230001, Anhui, China.
authors.forename: Ying-Chao
authors.initials: YC
authors.lastname: Wu
authors.affiliation: Anhui Medical University Hefei 230001, Anhui, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Chinese General Hospital of The Air Force Beijing 100142, China.
authors.forename: Jin-Jie
authors.initials: JJ
authors.lastname: Sun
authors.affiliation: Chinese General Hospital of The Air Force Beijing 100142, China.
authors.forename: Zhi-Kang
authors.initials: ZK
authors.lastname: Zou
authors.affiliation: Chinese General Hospital of The Air Force Beijing 100142, China.
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Ma
keywords: Breast cancer; dietary factor; meta-analysis