title: Effect of the cumin cyminum L. Intake on Weight Loss, Metabolic Profiles and Biomarkers of Oxidative Stress in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
abstract: BACKGROUND
  The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects.
  
  
  METHODS
  This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention.
  
  
  RESULTS
  Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m(2), respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02).
  
  
  CONCLUSIONS
  Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Taghizadeh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Memarzadeh
authors.forename: Zatollah
authors.initials: Z
authors.lastname: Asemi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Esmaillzadeh
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D028527:Cuminum; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007492:Iran; D007783:Lactones / Q000008:administration & dosage; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D000077403:Orlistat; D050177:Overweight / Q000188:drug therapy*; D018384:Oxidative Stress; D008517:Phytotherapy; D010919:Placebos; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D007328:Insulin; D007783:Lactones; D010919:Placebos; D000077403:Orlistat; D005978:Glutathione