title: Vincristine-induced neuropathy: Atypical electrophysiological patterns in children.
abstract: BACKGROUND
  Vincristine is an antimitotic agent used for treatment of leukemia, lymphomas, and cancers. Its main side effect is a dose-related, length-dependent (LD) axonal neuropathy.
  
  
  METHODS
  We performed electrodiagnostic (EDx) examinations in 17 children who had been treated with vincristine and who presented with the clinical picture of a peripheral neuropathy.
  
  
  RESULTS
  The mean dose of vincristine was 8.5 ± 4.0 mg/m(2) . Clinical motor symptoms were more frequent and more severe than sensory ones. Thirteen children presented with a motor deficit, 4 of whom could no longer walk. EDx examination showed an axonal neuropathy with a non-length-dependent (NLD) pattern in 9 children and an LD pattern in 8. A major motor predominance was encountered in 12 patients.
  
  
  CONCLUSIONS
  The electrophysiological and clinical motor predominance described differs from the mainly sensory neuropathy reported in adults. Incomplete myelination due to young age may have resulted in greater sensitivity of some nerves to neurotoxic agents.
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Courtemanche
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.|Centre de Référence Maladies Neuromusculaires Nantes Angers, CHU de Nantes, Nantes, France.
authors.forename: Armelle
authors.initials: A
authors.lastname: Magot
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.
authors.forename: Yolaine
authors.initials: Y
authors.lastname: Ollivier
authors.affiliation: Service d'Oncologie Pédiatrique, Hôpital Mère-Enfant, CHU de Nantes, Nantes, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Rialland
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.
authors.forename: Laurène
authors.initials: L
authors.lastname: Leclair-Visonneau
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.
authors.forename: Guillemette
authors.initials: G
authors.lastname: Fayet
authors.affiliation: Service de Neurologie, CHU de Saint-Etienne, Saint-Etienne, France.
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Camdessanché
authors.affiliation: Laboratoire d'Explorations Fonctionnelles, Hôtel-Dieu, CHU de Nantes, 44093, Nantes, France.|Centre de Référence Maladies Neuromusculaires Nantes Angers, CHU de Nantes, Nantes, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Péréon
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D012189:Retrospective Studies; D014750:Vincristine / Q000009:adverse effects*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine
keywords: mononeuritis multiplex; motor neuropathy; neurotoxicity; pediatric cancers; toxic neuropathy; vincristine