title: Importance of early absolute lymphocyte count after allogeneic stem cell transplantation: a retrospective study.
abstract: BACKGROUND
  Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells.
  
  
  METHODS
  We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection.
  
  
  RESULTS
  Patients presenting with lymphocyte counts of <300 × 103/μL on D+30 have a 3.76 times greater risk of death in <100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups.
  
  
  CONCLUSIONS
  In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT.
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Rigoni
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Scroferneker
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: B S
authors.initials: BS
authors.lastname: Pitombeira
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Ottoni
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Paz
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Fischer
authors.affiliation: Pediatric Oncology, Hospital Santo Antônio, Porto Alegre, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Michalowski
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Pezzi
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Amorin
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Valim
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Baggio
authors.affiliation: Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: Á
authors.initials: Á
authors.lastname: Laureano
authors.affiliation: Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: da Silva
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil. Electronic address: lsilla@hcpa.ufrgs.br.
authors.forename: L
authors.initials: L
authors.lastname: Silla
authors.affiliation: Hematology and Bone Marrow Transplantation, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Daudt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood* / Q000401:mortality / Q000628:therapy*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult