title: [The assessment of C4d urinary excretion in early and late post kidney transplant periods].
abstract: BACKGROUND
  Recent data describes the involvement of compliment elements in humoral kidney graft rejection. The C4d deposits in peritubular capilars are the marker of compliment activity and the element of humoral acute graft rejection. The aim of the study was the assessment of C4d urinary excretion in early and late post-kidney transplant periods.
  
  
  METHODS
  The study comprised 185 patients who underwent kidney allograft transplantation (KTx). The urinary specimens taken from the morning urine portion was assessed by ELISA test for C4d excretion. To increase the objectivity of the assessment all measurements were divided by urinary creatinine excretion. The study population was grouped according the post-transplant time i.e. <1 and >1 year after KTx.
  
  
  RESULTS
  In the study the C4d urinary excretion in patients <1 year and >1 year post kidney transplantation were 4.6 ± 7.5 and 5.3 ± 7.9 ng/mgCr, respectively. The mean C4d excretion was 4.8 ± 7.6 ng/mgCr. The values did not differ significantly. The direct assessment of C4d excretion (not divided per creatinuria) were also comparable in the study groups (207.2 ± 261.8 ng/ml and 212.9 ± 249.3 ng/ml, respectively).
  
  
  CONCLUSIONS
  C4d urinary excretion did not depend on post-transplant time.
authors.forename: Rafał
authors.initials: R
authors.lastname: Zwiech
mesh_terms: D000328:Adult; D064591:Allografts / Q000276:immunology; D015415:Biomarkers / Q000652:urine; D015935:Complement C4b / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000652:urine*; D011044:Poland; D011379:Prognosis; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d