title: Alterations of host cell ubiquitination machinery by pathogenic bacteria.
abstract: Response of immune and non-immune cells to pathogens infections is a very dynamic process. It involves the activation/modulation of many pathways leading to actin remodeling, membrane engulfing, phagocytosis, vesicle trafficking, phagolysosome formation, aiming at the destruction of the intruder. These sophisticated and rapid mechanisms rely on post-translational modifications (PTMs) of key host cells' factors, and bacteria have developed various strategies to manipulate them to favor their survival. Among these important PTMs, ubiquitination has emerged as a major mediator/modulator/regulator of host cells response to infections that pathogens have also learned to use for their own benefit. In this mini-review, we summarize our current knowledge about the normal functions of ubiquitination during host cell infection, and we detail its hijacking by model pathogens to escape clearance and to proliferate.
authors.affiliation: Cellular Stress, Centre de Recherche en Carcérologie de Marseille, INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes Marseille, France ; Infections, Gender and Pregnancy Laboratory, URMITE-IRD198, INSERM U1095, CNRS UMR7278, Aix-Marseille University Marseille, France.
authors.forename: Jaafar
authors.initials: J
authors.lastname: Alomairi
authors.affiliation: Cellular Stress, Centre de Recherche en Carcérologie de Marseille, INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes Marseille, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bonacci
authors.affiliation: Infections, Gender and Pregnancy Laboratory, URMITE-IRD198, INSERM U1095, CNRS UMR7278, Aix-Marseille University Marseille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Ghigo
authors.affiliation: Cellular Stress, Centre de Recherche en Carcérologie de Marseille, INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes Marseille, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Soubeyran
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D001424:Bacterial Infections / Q000378:metabolism* / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D054875:Ubiquitination
chemical_list: D001426:Bacterial Proteins
keywords: cell signaling; immunological response; intracellular bacterial pathogens; phagocytosis; post-translational modifications; ubiquitin; xenophagy