title: Atrial fibrillation and gastroesophageal reflux disease: From the cardiologist perspective.
abstract: We have read with interest the paper by Roman C. and colleagues discussing the relationship between gastroesophageal reflux disease and atrial fibrillation. The review is presenting the available evidence for the common pathogenic mechanisms. However, from a cardiologist perspective, some available data were not highlighted in the review, cardiovascular involvement in gastroesophageal reflux is less assessed. Hypertension, obesity or diabetes mellitus are substrate for left atrial remodeling that initiate and sustained atrial fibrillation development. One of the pathophysiologic mechanisms in atrial fibrillation is the presence of a trigger. Gastroesophageal reflux could be only a trigger for this arrhythmia. We believe that atrial fibrillation should be considered as possible extraesophageal syndrome in the gastroesophageal reflux classification.
authors.affiliation: Mariana Floria, Gr. T. Popa University of Medicine and Pharmacy, 700111 Iasi, Romania.
authors.forename: Mariana
authors.initials: M
authors.lastname: Floria
authors.affiliation: Mariana Floria, Gr. T. Popa University of Medicine and Pharmacy, 700111 Iasi, Romania.
authors.forename: Vasile Liviu
authors.initials: VL
authors.lastname: Drug
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology*; D005764:Gastroesophageal Reflux / Q000453:epidemiology*; D006801:Humans
keywords: Atrial fibrillation; Gastroesophageal reflux disease; Substrate; Trigger; Vagal stimulation