title: [The effect and the analysis of the influence factors of sublingual immunotherapy on patients with pharyngitis and allergy to house dust mite].
abstract: OBJECTIVE
  To evaluate the effect of sublingual specific immunotherapy (SLIT) on patients with pharyngitis and allergy to house dust mite and to discuss the influence of different treatments, single and multiple allergen sensitization and genders on SLIT.
  
  
  METHODS
  We recorded the total medicine score (TMS) and self evaluation of 53 patients with pharyngitis and allergy to house dust mite before and 6 months after the treatment. Control group included 25 patients only treated with anti-allergic drugs. Treatment group included 28 patients accept SLIT. Based on different dosage regimens, treated patients were divided into SLIT group and comprehensive group; Based on the results of skin prick, treated patients were divided into dust mite group and multiple group; Based genders, treated patients were divided into male and female group. We compared the effective rate (ER)and decreasing percent of TMS (Dp-TMS) between control and treatment group, and also different groups in treatment group.
  
  
  RESULTS
  The ER and Dp-TMS of treatment group is significantly higher than control group, (P < 0.01). The ER of SLIT and comprehensive group respectively is 72.73% and 76.47%without significant difference (P > 0.05). The ER and Dp-TMS of dust mite group and multiple group respectively is 61. 54%, 94. 46%,66. 67%, 71.25% without significant difference (P > 0.05). The ER and Dp-TMS of male and female respectively are 58.33%, 66.67%, 83.33%, 97.04% with significant difference (P > 0.05), while the Dp-TMS is not (P > 0.05).
  
  
  CONCLUSIONS
  The SLIT is effective to patients with pharyngitis and allergy to house dust mite; The therapeutic schedule, single and multiple allergen sensitization have no effects on SLIT in patients with pharyngitis and allergy to house dust mite. However, genders have influence on it.
mesh_terms: D000286:Administration, Sublingual; D000485:Allergens; D000818:Animals; D018926:Anti-Allergic Agents; D039741:Antigens, Dermatophagoides; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000628:therapy*; D008297:Male; D010612:Pharyngitis / Q000209:etiology / Q000628:therapy*; D039981:Pyroglyphidae; D012647:Self-Assessment; D063729:Sublingual Immunotherapy
chemical_list: D000485:Allergens; D018926:Anti-Allergic Agents; D039741:Antigens, Dermatophagoides