title: Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study.
abstract: OBJECTIVE
  To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia.
  
  
  METHODS
  Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl).
  
  
  RESULTS
  Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status.
  
  
  CONCLUSIONS
  Prednisone can be used safely in symptomatic HF patients with hyperuricemia.
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Hong
authors.initials: H
authors.lastname: Meng
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Jianlong
authors.initials: J
authors.lastname: Zhai
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Zhen
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Qingzhen
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Mingqi
authors.initials: M
authors.lastname: Zheng
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Guoping
authors.initials: G
authors.lastname: Ma
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Lishuang
authors.initials: L
authors.lastname: Ji
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Linan
authors.initials: L
authors.lastname: Duan
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Lizhuo
authors.initials: L
authors.lastname: Li
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
authors.forename: Kunshen
authors.initials: K
authors.lastname: Liu
authors.affiliation: From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University. dr.liuchao@gmail.com ksliud@sohu.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006074:Gout Suppressants / Q000009:adverse effects / Q000627:therapeutic use*; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood
chemical_list: D006074:Gout Suppressants; D014527:Uric Acid; D003404:Creatinine; D011241:Prednisone
keywords: HEART FAILURE; HYPERURICEMIA; PREDNISONE; RENAL FUNCTION