title: Myopathy and eosinophilic pneumonia coincidentally induced by treatment with daptomycin.
abstract: A 34-year-old man with 22q11.2 deletion syndrome (DiGeorge syndrome) concurrently suffered from myopathy and eosinophilic pneumonia shortly after receiving daptomycin (DAP) for right-sided infective endocarditis. The simultaneous occurrence of these phenomena in relation to DAP therapy has not been previously well described. An allergic reaction was suspected as a possible etiology of these DAP-related complications. This case highlights the need for close observation in order to detect both musculoskeletal and respiratory disorders from the start of DAP therapy. Physicians should pay more attention to this new drug, which is expected to be frequently used in various clinical settings.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Hideharu
authors.initials: H
authors.lastname: Hagiya
authors.forename: Kou
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Kikuko
authors.initials: K
authors.lastname: Asano
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Terasaka
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kimura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nada
authors.forename: Eri
authors.initials: E
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Waseda
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hanayama
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D017576:Daptomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D004062:DiGeorge Syndrome; D004697:Endocarditis, Bacterial / Q000188:drug therapy; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin