title: Biological therapies in osteoarthritis.
abstract: Given the paucity of effective therapies and the increasing prevalence of osteoarthritis (OA) with ageing and overweight populations, new therapies for this painful, life-impairing condition are desperately needed, for both symptom relief and structural modification. With a growing understanding that OA involves multiple tissue pathologies including inflammation, many more therapeutic targets have been identified. This review will provide a current overview on the role of biologics in OA, including anti-tumour necrosis factor agents, growth factors and interleukin-1 antagonists.
authors.forename: Claire Y J
authors.initials: CY
authors.lastname: Wenham
authors.forename: Michael
authors.initials: M
authors.lastname: McDermott
authors.affiliation: Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Chapeltown Rd, Leeds LS7 4SA, UK. p.conaghan@leeds.ac.uk.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Conaghan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D010003:Osteoarthritis / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D036341:Intercellular Signaling Peptides and Proteins; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha