title: Bio-optics based sensation imaging for breast tumor detection using tissue characterization.
abstract: The tissue inclusion parameter estimation method is proposed to measure the stiffness as well as geometric parameters. The estimation is performed based on the tactile data obtained at the surface of the tissue using an optical tactile sensation imaging system (TSIS). A forward algorithm is designed to comprehensively predict the tactile data based on the mechanical properties of tissue inclusion using finite element modeling (FEM). This forward information is used to develop an inversion algorithm that will be used to extract the size, depth, and Young's modulus of a tissue inclusion from the tactile data. We utilize the artificial neural network (ANN) for the inversion algorithm. The proposed estimation method was validated by a realistic tissue phantom with stiff inclusions. The experimental results showed that the proposed estimation method can measure the size, depth, and Young's modulus of a tissue inclusion with 0.58%, 3.82%, and 2.51% relative errors, respectively. The obtained results prove that the proposed method has potential to become a useful screening and diagnostic method for breast cancer.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Keimyung University, 1095, Dalgubeol-daero, Daegu 704-701, Korea. segeberg@gmail.com.
authors.forename: Jong-Ha
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Dongsan Medical Center, Keimyung University, 1095, Dalgubeol-daero, Daegu 704-701, Korea. ynkim@dsmc.or.kr.
authors.forename: Yoon Nyun
authors.initials: YN
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Keimyung University, 1095, Dalgubeol-daero, Daegu 704-701, Korea. hjpark@kmu.ac.kr.
authors.forename: Hee-Jun
authors.initials: HJ
authors.lastname: Park
mesh_terms: D015374:Biosensing Techniques; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D016571:Neural Networks, Computer; D055095:Optics and Photonics