title: Adiponectin as a Target in Obesity-related Inflammatory State.
abstract: Accumulating evidence indicates that low grade inflammation is closely associated with obesity-related disorders including type 2 diabetes, hypertension and atherosclerosis. Adiponectin is a fat-derived plasma protein with anti-inflammatory functions. Circulating levels of adiponectin are decreased in obese states, and these conditions are broadly associated with various obesity-related diseases. Furthermore, adiponectin has direct protective functions against cardiovascular disease, cerebrovascular disease, non-alcoholic steatohepatitis (NASH) and chronic kidney disease (CKD). In this review, we will focus on the protective functions of adiponectin against these obesity-related diseases from the view point of its anti-inflammatory properties.
authors.forename: Koji
authors.initials: K
authors.lastname: Ohashi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yuasa
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
authors.affiliation: Molecular Cardiovascular Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-Ku, Nagoya, Japan. nouchi@med.nagoya-u.ac.jp.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
mesh_terms: D052242:Adiponectin / Q000378:metabolism* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism* / Q000517:prevention & control; D007333:Insulin Resistance; D058990:Molecular Targeted Therapy; D065626:Non-alcoholic Fatty Liver Disease / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism*; D065840:Protective Factors; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D052242:Adiponectin; D000893:Anti-Inflammatory Agents