title: One-step synthesis of highly-biocompatible spherical gold nanoparticles using Artocarpus heterophyllus Lam. (jackfruit) fruit extract and its effect on pathogens.
abstract: BACKGROUND
  Novel approaches for the synthesis of gold nanoparticles (AuNPs) are of great importance due to its vast spectrum of applications in diverse fields, including medical diagnostics and therapeutics. Te presented study reports the successful AuNPs' synthesis using Artocarpus heterophyllus Lam. extract, and provides detailed characterization and evaluation of its antibacterial potential.
  
  
  OBJECTIVE
  The aim was to develop a cost-effective and environmentally friendly synthesis method of gold nanoparticles using aqueous fruit extract of Artocarpus heterophyllus Lam. as a reducing and capping agent, which has proven activity against human pathogens, such as microbial species E.coli and Streptobacillus sps.
  
  
  METHODS
  Characterizations were carried out using ultraviolet-visible (UV-Vis) spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray and Fourier-Transform infra-red spectroscopy (FT-IR).
  
  
  RESULTS
  SEM images showed the formation of gold nanoparticles with an average size of 20-25 nm. Spectra collected while infra-red analysis contained broad peaks in ranges from 4000-400 cm -1 .
  
  
  CONCLUSIONS
  It can be concluded that the fruit of Artocarpus heterophyllus Lam. can be good source for synthesis of gold nanoparticles which showed antimicrobial activity against investigated microbes, in particul E. coli, and Streptobacillus. An important outcome of this study will be the development of value-added products from the medicinal plant Artocarpus heterophyllus Lam. for the biomedical and nanotechnology-based industries.
authors.affiliation: Department of Biotechnology, Shridevi Institute of Engineering & Technology, Tumkur, Karnataka, India.
authors.forename: Nagaraj
authors.initials: N
authors.lastname: Basavegowda
authors.affiliation: Department of Biotechnology, Shridevi Institute of Engineering & Technology, Tumkur, Karnataka, India.
authors.forename: Gowri
authors.initials: G
authors.lastname: Dhanya Kumar
authors.affiliation: Department of Chemistry and Technology of Polymers, Cracow University of Technology, Cracow, Poland.
authors.forename: Bozena
authors.initials: B
authors.lastname: Tyliszczak
authors.affiliation: Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Wzorek
authors.affiliation: Institute of Inorganic Chemistry and Technology, Cracow University of Technology, Cracow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sobczak-Kupiec
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D001672:Biocompatible Materials / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D005638:Fruit / Q000737:chemistry; D006046:Gold / Q000494:pharmacology*; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry*; D013288:Streptobacillus / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D010936:Plant Extracts; D006046:Gold