title: Neurobiological and clinical variables associated with alcohol abuse in bulimia nervosa.
abstract: The study was aimed at analysing the reciprocal relationships of several clinical and neurobiological items in order to predict alcohol misuse in patients with bulimia nervosa (BN). Seventy BN patients and 70 healthy controls were assessed for depression, impulsivity, borderline personality traits and self-defeating behaviours using specific scales; serum cortisol and 24-hour urinary excretion of serotonin and 5-hydroxiindolacetic acid were also assessed. The study confirmed the implications of these clinical factors for alcohol misuse in BN patients, but the results suggested that depressive symptoms and hypercortisolism could lie behind these relationships.
authors.affiliation: Faculty of Medicine, University of Extremadura, Badajoz, Spain; Mental Health and Eating Disorders Unit (University Hospital Network), Badajoz, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Vaz-Leal
authors.forename: María I
authors.initials: MI
authors.lastname: Ramos-Fuentes
authors.forename: Laura
authors.initials: L
authors.lastname: Rodríguez-Santos
authors.forename: Isabel S
authors.initials: IS
authors.lastname: Flores-Mateos
authors.forename: Andrés
authors.initials: A
authors.lastname: Franco-Zambrano
authors.forename: Luis
authors.initials: L
authors.lastname: Rojo-Moreno
authors.forename: Luis
authors.initials: L
authors.lastname: Beato-Fernández
mesh_terms: D019342:Acetic Acid / Q000652:urine; D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000523:psychology; D001883:Borderline Personality Disorder; D052018:Bulimia Nervosa / Q000150:complications* / Q000523:psychology*; D003863:Depression / Q000150:complications / Q000523:psychology; D003866:Depressive Disorder / Q000150:complications / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007175:Impulsive Behavior; D007211:Indoles / Q000652:urine; D008297:Male; D008960:Models, Psychological; D009446:Neurobiology; D012701:Serotonin / Q000378:metabolism / Q000652:urine*; D055815:Young Adult
chemical_list: D007211:Indoles; C026785:5-hydroxyindole; D012701:Serotonin; D019342:Acetic Acid; D006854:Hydrocortisone
keywords: alcohol; bulimia nervosa; cortisol; hypothalamic-pituitary-adrenal (HPA) axis; serotonin