title: Emerging roles for scavenger receptor SREC-I in immunity.
abstract: SREC-I is a class F scavenger receptor with key role in the immune response, particularly in antigen presenting cell (APC) such as macrophages and dendritic cells (DC). This receptor is able to mediate engulfment of dead cells as well as endocytosis of heat shock protein (HSP)-antigen complexes. SREC-I could thus potentially mediate the tolerizing influence of apoptotic cells or the immunostimulatory effects of HSP-peptide complexes, depending on context. This receptor was able to mediate presentation of external antigens, bound to HSPs through both the class II pathway as well as cross presentation via MHC class I complexes. In addition to its recently established role in adaptive immunity, emerging studies are indicating a broad role in innate immunity and regulation of cell signaling through Toll Like Receptors (TLR). SREC-I may thus play a key role in APC function by coordinating immune responses to internal and external antigens in APC.
authors.affiliation: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Murshid
authors.affiliation: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States; School of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
authors.forename: Thiago J
authors.initials: TJ
authors.lastname: Borges
authors.affiliation: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, United States. Electronic address: scalderw@bidmc.harvard.edu.
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Calderwood
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D017209:Apoptosis / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D004705:Endocytosis / Q000276:immunology; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D051128:Scavenger Receptors, Class F / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D018840:HSP70 Heat-Shock Proteins; C495126:SCARF1 protein, human; D051128:Scavenger Receptors, Class F; D051193:Toll-Like Receptors
keywords: Antigen cross presentation; Immunity; SREC-I; Scavenger receptor