title: Impact of repetitive transcranial magnetic stimulation on post-stroke dysmnesia and the role of BDNF Val66Met SNP.
abstract: BACKGROUND
  Little is known about the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on dysmnesia and the impact of brain nucleotide neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphism (SNP). This study investigated the impact of low-frequency rTMS on post-stroke dysmnesia and the impact of BDNF Val66Met SNP.
  
  
  METHODS
  Forty patients with post-stroke dysmnesia were prospectively randomized into the rTMS and sham groups. BDNF Val66Met SNP was determined using restriction fragment length polymorphism. Montreal Cognitive Assessment (MoCA), Loewenstein Occupational Therapy of Cognitive Assessment (LOTCA), and Rivermead Behavior Memory Test (RBMT) scores, as well as plasma BDNF concentrations, were measured at baseline and at 3 days and 2 months post-treatment.
  
  
  RESULTS
  MoCA, LOTCA, and RBMT scores were higher after rTMS. Three days after treatment, BDNF decreased in the rTMS group but it increased in the sham group (P<0.05). Two months after treatment, RMBT scores in the rTMS group were higher than in the sham group, but not MoCA and LOTCA scores.
  
  
  CONCLUSIONS
  Low-frequency rTMS may improve after-stoke memory through various pathways, which may involve polymorphisms and several neural genes, but not through an increase in BDNF levels.
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center, Beijing, China (mainland).
authors.forename: Haitao
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Neurorehabilitation, Capital Medical University School of Rehabilitation Medicine, China Rehabilitation Research Center, Beijing, China (mainland).
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Neurorehabilitation, Institute of Rehabilitation Medicine of China, China Rehabilitation Research Center, Beijing, China (mainland).
authors.forename: Mei
authors.initials: M
authors.lastname: Wen
authors.affiliation: Department of Neurology, China Rehabilitation Research Center, Beijing, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008568:Memory; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020521:Stroke / Q000097:blood / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation / Q000009:adverse effects
chemical_list: D019208:Brain-Derived Neurotrophic Factor