title: [Differential diagnosis of brain gliomas by positron emission tomography using various radiopharmaceuticals].
abstract: OBJECTIVE
  To comparatively study the diagnostic capabilities of positron emission tomography (PET) with various tumorotropic radiopharmaceuticals (TRPs) in detecting malignant brain gliomas (BG) and estimating their degree.
  
  
  METHODS
  One hundred and fourteen patients, including 47 with histologically verified glioblastoma multiforme (GBM), 27 with anaplastic astrocytoma (AA), 23 with benign astrocytoma (BA), and 17 with postoperative cysts, were examined. PET was performed using TRPs: 18F-fluorodesoxyglucose (18F-FDG), 11C-sodium butyrate (11C-SB), 11C-L-methionine (11C-MET), and 11C-choline (11C-COL).
  
  
  RESULTS
  Malignant gliomas (GBM and AA) were clearly visualized by PET using 11C-MET, 11C-CHOL, and 11C-SB. 18F-FDG PET visualization of tumors was difficult because of increased RP accumulation in the cerebral cortex. WHO grades II-III gliomas were completely visualized by 11C-MET PET. Only some tumors were clearly displayed by PET with 11C-CHOL and 11C-SB. The accumulation indices (AI) obtained by 11C-CHOL PET in patients with malignant gliomas were, on average, 4.0- and 5.5-fold higher than those by 11C-MET and 11C-SB PET, respectively. Significant differences (p < 0.001) in AI obtained by "C-CHOL ("C-CHOL-AI) PET were first established between the patients with GBM (WHO grade IV) and those with AA (WHO grade III).
  
  
  CONCLUSIONS
  11C-CHOL PET is the most sensitive method to identify gliomas and estimate their grade. The advantage of 11C-MET PET is the possible imaging of the entire volume of viable tumor tissue.
authors.forename: N A
authors.initials: NA
authors.lastname: Kostenikov
authors.forename: L A
authors.initials: LA
authors.lastname: Tiutin
authors.forename: N P
authors.initials: NP
authors.lastname: Fadeev
authors.forename: A F
authors.initials: AF
authors.lastname: Panfilenko
authors.forename: E M
authors.initials: EM
authors.lastname: Zykov
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Iliushchenko
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Makeeva
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D011379:Prognosis; D019275:Radiopharmaceuticals / Q000145:classification / Q000494:pharmacology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012426:Russia; D012680:Sensitivity and Specificity
chemical_list: D019275:Radiopharmaceuticals