title: Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration.
abstract: In order to understand the pathophysiology of temporal lobe epilepsy (TLE), and thus to develop new pharmacological treatments, in vivo animal models that present features similar to those seen in TLE patients have been developed during the last four decades. Some of these models are based on the systemic administration of chemoconvulsants to induce an initial precipitating injury (status epilepticus) that is followed by the appearance of recurrent seizures originating from limbic structures. In this paper we will review two chemically-induced TLE models, namely the kainic acid and pilocarpine models, which have been widely employed in basic epilepsy research. Specifically, we will take into consideration their behavioral, electroencephalographic and neuropathologic features. We will also evaluate the response of these models to anti-epileptic drugs and the impact they might have in developing new treatments for TLE.
authors.affiliation: Montreal Neurological Institute and Department of Neurology & Neurosurgery, McGill University, Montréal, QC, Canada H3A 2B4.
authors.forename: Maxime
authors.initials: M
authors.lastname: Lévesque
authors.affiliation: Montreal Neurological Institute and Department of Neurology & Neurosurgery, McGill University, Montréal, QC, Canada H3A 2B4; Montreal Neurological Institute and Department of Physiology, McGill University, Montréal, QC, Canada H3A 2B4; Department of Experimental Medicine, Faculty of Medicine & Odontoiatry, Sapienza University of Rome, Rome, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Avoli
authors.affiliation: Aix Marseille Université, Inserm, INS UMR_S 1106, 13005, Marseille, France. Electronic address: christophe.bernard@univ-amu.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bernard
mesh_terms: D000818:Animals; D003292:Convulsants; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000187:drug effects; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced* / Q000503:physiopathology*; D007608:Kainic Acid; D009415:Nerve Net / Q000187:drug effects / Q000503:physiopathology*; D010862:Pilocarpine; D013702:Temporal Lobe / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D003292:Convulsants; D010862:Pilocarpine; D007608:Kainic Acid
keywords: Animal models; Kainic acid; Pilocarpine; Temporal lobe epilepsy