title: Childhood cancer survivors: considerations for surgeons in the transition from pediatric to adult care.
abstract: There are over 380,000 childhood cancer survivors (CCS) alive in the US, and the population is growing. CCS face significant long-term morbidity and mortality as a consequence of their cancer treatment and thus require lifelong, risk-based health care focused on surveillance and early intervention to minimize the impact of late effects and second malignant neoplasms (SMN). Surgeons play a critical role in the treatment of childhood cancer and the subsequent management of long-term health complications. In this review, we provide an overview of late effects associated with cancer surgeries, potential late effects that may require surgery as an adult, and cancer therapies that may impact future safe surgery and anesthesia. We also describe the barriers to successful transition from pediatric to adult health care for CCS and the importance of treatment summaries, surveillance guidelines, and survivorship care plans for surgeons caring for CCS.
authors.affiliation: Department of Pediatrics, Section of Hematology, Oncology and Stem Cell Transplantation, Comer Children׳s Hospital, University of Chicago, 5841S. Maryland Ave. MC 4060, Chicago, Illinois 60637. Electronic address: thenderson@peds.bsd.uchicago.edu.
authors.forename: Tara O
authors.initials: TO
authors.lastname: Henderson
authors.affiliation: Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Nathan
mesh_terms: D000328:Adult; D002648:Child; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control / Q000601:surgery*; D017741:Survivors; D060305:Transition to Adult Care / Q000592:standards*
keywords: Cancer survivors; Late effects; Second malignant neoplasms; Surveillance; Survivorship care plans