title: The interaction of anticancer therapies with tumor-associated macrophages.
abstract: Macrophages are essential components of the inflammatory microenvironment of tumors. Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs, antiangiogenic agents, and immunotherapy, including checkpoint blockade, all profoundly influence or depend on the function of tumor-associated macrophages (TAMs). Chemotherapy and radiotherapy can have dual influences on TAMs in that a misdirected macrophage-orchestrated tissue repair response can result in chemoresistance, but in other circumstances, TAMs are essential for effective therapy. A better understanding of the interaction of anticancer therapies with innate immunity, and TAMs in particular, may pave the way to better patient selection and innovative combinations of conventional approaches with immunotherapy.
authors.affiliation: A. Mantovani and P. Allavena are at the IRCCS Humanitas Clinical and Research Center and Humanitas University, 20089 Rozzano, Milano, Italy alberto.mantovani@humanitasresearch.it paola.allavena@humanitasresearch.it.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.affiliation: A. Mantovani and P. Allavena are at the IRCCS Humanitas Clinical and Research Center and Humanitas University, 20089 Rozzano, Milano, Italy alberto.mantovani@humanitasresearch.it paola.allavena@humanitasresearch.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D059016:Tumor Microenvironment / Q000276:immunology*