title: Bioactive diphenyl ether derivatives from a gorgonian-derived fungus Talaromyces sp.
abstract: Three new diphenyl ether derivatives, talaromycins A-C (1-3, resp.), together with six known analogs, 4-9, were isolated from a gorgonian-derived fungus, Talaromyces sp. The structures of the new compounds were determined by analysis of extensive NMR spectroscopic data. All of the isolated metabolites, 1-9, were evaluated for their cytotoxic and antifouling activities. Compound 4 exhibited pronounced cytotoxicity against the tested human cell lines with the IC50 values ranging from 4.3 to 9.8 μM. Compounds 3, 5, 8, and 9 showed potent antifouling activities against the larval settlement of the barnacle Balanus amphitrite with the EC50 values ranging from 2.2 to 4.8 μg/ml.
authors.affiliation: Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China, (phone/fax: +86-532-82031536).
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.forename: Chang-Lun
authors.initials: CL
authors.lastname: Shao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: She
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects; D057219:Biofouling; D045744:Cell Line, Tumor; D006801:Humans; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032901:Talaromyces / Q000737:chemistry*; D001468:Thoracica / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D010647:Phenyl Ethers; D011090:Polyenes; D012459:Salicylates; D013141:Spiro Compounds; C416203:talaromycin B; C000603311:talaromycin C; C000603312:tenellic acid A methyl ester; C031538:phenyl ether
keywords: Antifouling activity; Cytotoxic activity; Diphenyl ether derivatives; Fungi; Talaromyces; Talaromycins A - C