title: [Research progress on processed Chinese medicine in vivo].
abstract: Processed Chinese medicine is the core of traditional Chinese medicine (TCM) industry chain,which directly affects the clinical efficacy and. safety of Chinese patent medicine and clinical formula Decoction pieces. Studied the variation of effective substance in vivo Chinese medicine processing before and after processed, clarifying the effective substance and processing principle is a top priority of the development of Chinese medicine processing. The traditional research method chiefly focus on the variation about chemicals in vitro of processed Chinese medicine, it cannot reveal that the integrity and complexity of processed Chinese medicine efficacy changes, so the change process is the focus of future research in vivo on the base of effective substance of TCM This paper described the research on the base of effective substance of TCM and Processed Chinese medicine research status in vitro, discussed the analytical methods (plasma chemistry, pharmacokinetics, metabonomics) of the dynamic process in vivo about processed Chinese medicine, and pointed out development and related problems in process in vivo on the base of effective substance of TCM, which could provided research ideas and methods for in-depth interpretation of Chinese medicine processing mechanism.
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Yao
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Yin-lian
authors.initials: YL
authors.lastname: Ma
authors.forename: Xue-zhu
authors.initials: XZ
authors.lastname: Gu
authors.forename: Cun
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008516:Medicine, Chinese Traditional
chemical_list: D004365:Drugs, Chinese Herbal