title: Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis.
abstract: OBJECTIVE
  Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis).
  
  
  METHODS
  Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer.
  
  
  RESULTS
  Among the fractions POR showed better activity. POR and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test POR significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method POR showed better analgesic activity than PE. POR showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE.
  
  
  CONCLUSIONS
  The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.
authors.affiliation: PDM College of Pharmacy, Bahadurgah, Haryana, India.
authors.forename: Saurabh
authors.initials: S
authors.lastname: Bhatia
authors.affiliation: Deptt. of Pharmaceutical Sciences, Jamia Hamdard, New Delhi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Sharma
authors.affiliation: Seoul National University, Republic of Korea, Korea.
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Division of Pharmaceutics, Faculty of Medical Sciences, Lovely Professional University, Phagwara, Punjab India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Nagpal
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
authors.forename: Tanmoy
authors.initials: T
authors.lastname: Bera
keywords: Analgesia; Carrageenan; Porphyra; Porphyran; Ulcer