title: Recurrence and metastasis of breast cancer is influenced by ovarian hormone's effect on breast cancer stem cells.
abstract: Cancer stem cells (CSCs) have recently attracted great interest because of their emerging role in initiation, progression and metastasis, combined with their intrinsic resistance to chemotherapy and radiation therapy. CSCs and its interaction with hormones in breast cancer are currently being investigated with the aim of uncovering the molecular mechanisms by which they evade conventional treatment regimens. In this review, we discuss recent experimental data and new perspectives in the area of steroid hormones and their cross-talk with breast CSCs. We have covered literature associated with biomarkers, hormone receptors and hormone responsive signaling pathways in breast CSC. In addition, we also discuss the role of miRNAs in hormone mediated regulation of breast CSCs.
authors.affiliation: Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, 5001 El Paso Drive, El Paso, TX 79905, USA.
authors.forename: Sushmita Bose
authors.initials: SB
authors.lastname: Nandy
authors.forename: Laxman
authors.initials: L
authors.lastname: Gangwani
authors.forename: Zeina
authors.initials: Z
authors.lastname: Nahleh
authors.forename: Ramadevi
authors.initials: R
authors.lastname: Subramani
authors.forename: Arunkumar
authors.initials: A
authors.lastname: Arumugam
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: de la Rosa
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Lakshmanaswamy
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers; D001943:Breast Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D010641:Phenotype; D011987:Receptors, Steroid / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D006728:Hormones; D035683:MicroRNAs; D011987:Receptors, Steroid
keywords: breast cancer; endocrine resistance; epithelial–mesenchymal transition; hormones; metastasis; miRNA; recurrence; stem cells