title: Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling.
abstract: We assessed phytochemical components of anthocyanins from purple sweet potato (PSP) and purple potato (PP) with UPLC-MS/MS, and investigated their inhibitory effect on inflammatory response in alcoholic liver disease (ALD). Results showed that serum AST and ALT levels in PP anthocyanins (PPAs) and PSP anthocyanins (PSPAs) treatments were lower than those of alcohol-treated group. PPAs and PSPAs could inhibit mRNA expressions of inflammatory factors (TNF-α, VCAM-1, IFN-γ and CXCL-1). The mRNA levels of NF-κB, STAT, and TLR in PPAs and PSPAs treatment groups were lower than in alcohol treatment group. Our results indicate that PP and PSP are good source of anti-inflammatory anthocyanins to prevent ALD.
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi 712100 , P.R. China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: b School of Biological Science and Engineering, Shaanxi University of Technology , Hanzhong , Shaanxi 723001 , P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi 712100 , P.R. China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Xie
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi 712100 , P.R. China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: b School of Biological Science and Engineering, Shaanxi University of Technology , Hanzhong , Shaanxi 723001 , P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: a College of Veterinary Medicine, Northwest A&F University , Yangling , Shaanxi 712100 , P.R. China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D054360:Chemokine CXCL1 / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005960:Glucosides / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy*; D007371:Interferon-gamma / Q000378:metabolism; D027723:Ipomoea batatas / Q000737:chemistry*; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D050796:STAT3 Transcription Factor / Q000378:metabolism; D053719:Tandem Mass Spectrometry; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D000872:Anthocyanins; D000893:Anti-Inflammatory Agents; D054360:Chemokine CXCL1; C475895:Cxcl1 protein, mouse; D005960:Glucosides; D016328:NF-kappa B; D010936:Plant Extracts; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; C493487:Tlr4 protein, mouse; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; C462279:cyanidin-3-O-beta-glucopyranoside; C000611354:petunidin 3-coumaroyl-rutinoside-5-glucoside; D000431:Ethanol; D007371:Interferon-gamma
keywords: alcoholic liver disease; anthocyanin; inflammation; purple potato; purple sweet potato