title: Thrombocytosis of Liver Metastasis from Colorectal Cancer as Predictive Factor.
abstract: There is increasing evidence that thrombocytosis is associated with tumor invasion and metastasis formation. It was shown in several solid tumor types that thrombocytosis prognosticates cancer progression. The aim of this study was to evaluate preoperative thrombocytosis as a potential prognostic biomarker in isolated metastases, in patients with liver metastasis of colorectal cancer (mCRC). Clinicopathological data of 166 patients with mCRC who had surgical resection between 2001 and 2011 were collected retrospectively. All primary tumors have been already resected. The platelet count was evaluated based on the standard preoperative blood profile. The patients were followed-up on average for 28 months. Overall survival (OS) of patients with thrombocytosis was significantly worse both in univariate (HR = 3.00, p = 0.03) and in multivariate analysis (HR = 4.68, p = 0.056) when adjusted for gender, age, tumor size and surgical margin. Thrombocytosis was also a good prognosticator of disease-free survival (DFS) with HR = 2.7, p = 0.018 and nearly significant in multivariate setting (HR = 2.26, p = 0.073). The platelet count is a valuable prognostic marker for the survival in patients with mCRC.
authors.affiliation: Tumorgenetika Human Biospecimen Collection and Research, 1147, Budapest, Kerékgyártó u. 36., Hungary.
authors.forename: Valéria
authors.initials: V
authors.lastname: Jósa
authors.forename: Marcin
authors.initials: M
authors.lastname: Krzystanek
authors.forename: Tamás
authors.initials: T
authors.lastname: Vass
authors.forename: Tamás
authors.initials: T
authors.lastname: Lang
authors.forename: Viktória
authors.initials: V
authors.lastname: Juhász
authors.forename: Kamilla
authors.initials: K
authors.lastname: Szilágyi
authors.forename: Balázs
authors.initials: B
authors.lastname: Tihanyi
authors.forename: László
authors.initials: L
authors.lastname: Harsányi
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szállási
authors.forename: Ferenc
authors.initials: F
authors.lastname: Salamon
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Baranyai
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013922:Thrombocytosis / Q000175:diagnosis / Q000209:etiology*