title: Serine protease HtrA1 as an inhibitor on proliferation invasion and migration of gastric cancer.
abstract: HtrA1, as serine protease lower expressed in various human solid tumors, can down-regulate cell growth and proliferation. In this study, we focus on whether overexpressed HtrA1 can inhibit the growth of gastric cancer in vitro. This study found the HtrA1 is lower expressed in gastric cancer tissue than in normal gastric tissue. When HtrA1 is highly expressing with recombinant plasmid in gastric cancer cell lines SGC-7901 and AGS, it weakened cell proliferation, invasion, and migration in vitro. These data suggested that HtrA1 as an inhibitor in gastric cancer cells resulted in anti-proliferation, reduced invasion, decreased migration, and suppressed growth and may be an effective molecular targets on gastric cancer treatment.
authors.affiliation: The First Affiliated Hospital of Henan University of Science and Technology, Xinxuefu Street, Luoyang, 471000, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhao
authors.forename: Huifang
authors.initials: H
authors.lastname: Li
authors.forename: Chuanyi
authors.initials: C
authors.lastname: Wang
authors.forename: Wanfang
authors.initials: W
authors.lastname: Xu
authors.forename: Junfeng
authors.initials: J
authors.lastname: Sun
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Zhao
mesh_terms: D017209:Apoptosis; D015153:Blotting, Western; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D049452:Green Fluorescent Proteins; D000074289:High-Temperature Requirement A Serine Peptidase 1; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D013270:Stomach / Q000201:enzymology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured
chemical_list: D012333:RNA, Messenger; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D000074289:High-Temperature Requirement A Serine Peptidase 1; C474012:HTRA1 protein, human; D012697:Serine Endopeptidases