title: Association of mean platelet volume level with in-hospital major adverse events in infective endocarditis.
abstract: We hypothesised that increased on-admission and follow-up mean platelet volume (MPV) levels would correlate with adverse outcomes in patients with infective endocarditis (IE). A total of 108 consecutive patients were grouped into two according to median MPV level (≤ 8.6 and > 8.6 fL). Patients with MPV level of > 8.6 fL had a significantly higher rate of end-stage renal disease, Staphylococcus aureus infection, higher CRP levels, embolic events and in-hospital mortality compared to patients with MPV levels ≤ 8.6 fL. In multivariable Cox regression analysis, previous history of IE, S. aureus infection, end-stage renal disease, depressed LVEF, early surgical intervention, vegetation size ≥ 10 mm, presence of perivalvular abscess, higher on-admission platelet count, CRP and MPV levels emerged as independent predictors of in-hospital unfavourable outcomes. Patients with embolic events and in-hospital mortality revealed an incremental trend for MPV levels compared to patients without any adverse events. Our study results suggest that both on-admission and follow-up MPV levels may be a simple and available biomarker for risk stratification of IE patients.
authors.affiliation: Department of Infectious Diseases, Turkish Armed Forces Health Command Health and Veterinary Services, Ankara, Turkey.
authors.forename: Duran
authors.initials: D
authors.lastname: Tok
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.forename: Derya
authors.initials: D
authors.lastname: Tok
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.forename: Ahmet
authors.initials: A
authors.lastname: İşleyen
authors.forename: Fatih
authors.initials: F
authors.lastname: Öksüz
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Mendi
authors.forename: Kumral
authors.initials: K
authors.lastname: Çağlı
authors.forename: Fatma Nurcan
authors.initials: FN
authors.lastname: Başar
authors.forename: Zehra
authors.initials: Z
authors.lastname: Gölbaşı
mesh_terms: D004617:Embolism / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D004697:Endocarditis, Bacterial / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008297:Male; D063847:Mean Platelet Volume / Q000706:statistics & numerical data*; D008875:Middle Aged; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D013223:Statistics as Topic; D015996:Survival Rate; D014421:Turkey / Q000453:epidemiology