title: Animal models of gastrointestinal and liver diseases. Animal models of visceral pain: pathophysiology, translational relevance, and challenges.
abstract: Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In contrast to somatic pain, visceral pain is generally vague, poorly localized, and characterized by hypersensitivity to a stimulus such as organ distension. Animal models have played a pivotal role in our understanding of the mechanisms underlying the pathophysiology of visceral pain. This review focuses on animal models of visceral pain and their translational relevance. In addition, the challenges of using animal models to develop novel therapeutic approaches to treat visceral pain will be discussed.
authors.affiliation: Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma beverley-greenwood@ouhsc.edu.
authors.forename: Beverley
authors.initials: B
authors.lastname: Greenwood-Van Meerveld
authors.affiliation: Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Dawn K
authors.initials: DK
authors.lastname: Prusator
authors.affiliation: Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Johnson
mesh_terms: D000818:Animals; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000378:metabolism / Q000503:physiopathology; D023421:Models, Animal; D059225:Nociception / Q000187:drug effects / Q000502:physiology; D035703:Therapies, Investigational / Q000379:methods; D057170:Translational Research, Biomedical; D059265:Visceral Pain / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology / Q000628:therapy
keywords: IBS; gastrointestinal; models; pain; rodent