title: Drimane sesquiterpenoids from the Aspergillus oryzae QXPC-4.
abstract: Three new drimane sesquiterpenoids, astellolides C-E (1-3, resp.), four new drimane sesquiterpenoid p-hydroxybenzoates, astellolides F-I (4-7, resp.), together with two known compounds astellolides A and B (8 and 9, resp.), have been isolated from the liquid culture of Aspergillus oryzae (strain No. QXPC-4). Their structures were established by comprehensive analysis of spectroscopic data. The relative and absolute configurations were determined on the basis of NOESY and CD data, together with single-crystal X-ray diffraction analyses of compounds 1-3. The metabolites were evaluated for their cytotoxic activities, however, no compounds showed a significant cytotoxicity against the tested cell lines at a concentration of 20 μM.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P. R. China, (phone/fax: +86-25-83593201).
authors.forename: Ren
authors.initials: R
authors.lastname: Ren
authors.forename: Chao-Jun
authors.initials: CJ
authors.lastname: Chen
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Hu
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Wen-Yong
authors.initials: WY
authors.lastname: Zhu
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Jiao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001236:Aspergillus oryzae / Q000737:chemistry*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane
keywords: Aspergillus oryzae; Astellolides C - I; Drimane sesquiterpenoids; Sesquiterpenoids