title: Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling.
abstract: Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.
authors.affiliation: Institute of Genetics, National Yang-Ming University, Taipei; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China; Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan, Republic of China.
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Tsai
authors.affiliation: Theodor-Boveri-Institut, Biozentrum, Lehrstuhl für Genetik und Neurobiologie, Universität Würzburg, Am Hubland, Würzburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Grimm
authors.affiliation: Institute of Genetics, National Yang-Ming University, Taipei; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: Ju-Lan
authors.initials: JL
authors.lastname: Chao
authors.affiliation: Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan, Republic of China.
authors.forename: Shih-Chin
authors.initials: SC
authors.lastname: Wang
authors.affiliation: Theodor-Boveri-Institut, Biozentrum, Lehrstuhl für Genetik und Neurobiologie, Universität Würzburg, Am Hubland, Würzburg, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Hofmeyer
authors.affiliation: Institut für Genetik, Universität Mainz, Mainz, Germany; Department of Entomology, China Agricultural University, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.affiliation: Institut für Genetik, Universität Mainz, Mainz, Germany.
authors.forename: Fred
authors.initials: F
authors.lastname: Eichinger
authors.affiliation: Institut für Genetik, Universität Mainz, Mainz, Germany.
authors.forename: Theoni
authors.initials: T
authors.lastname: Michalopoulou
authors.affiliation: Institute of Genetics, National Yang-Ming University, Taipei; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: Chi-Kuang
authors.initials: CK
authors.lastname: Yao
authors.affiliation: Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan, Republic of China.
authors.forename: Chih-Hsuan
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Department of Life Science and Life Science Center, Tunghai University, Taichung, Taiwan, Republic of China.
authors.forename: Shih-Han
authors.initials: SH
authors.lastname: Lin
authors.affiliation: Institute of Genetics, National Yang-Ming University, Taipei; Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.
authors.forename: Y Henry
authors.initials: YH
authors.lastname: Sun
authors.affiliation: Theodor-Boveri-Institut, Biozentrum, Lehrstuhl für Genetik und Neurobiologie, Universität Würzburg, Am Hubland, Würzburg, Germany; Institut für Genetik, Universität Mainz, Mainz, Germany.
authors.forename: Gert O
authors.initials: GO
authors.lastname: Pflugfelder
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D005123:Eye / Q000166:cytology / Q000196:embryology*; D053612:Janus Kinases / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D050791:STAT Transcription Factors; D020825:T-Box Domain Proteins; D014157:Transcription Factors; C072962:bi protein, Drosophila; D053612:Janus Kinases; C085845:hop protein, Drosophila