title: Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases.
abstract: Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main source of lipids in the MD, is rich in minor phenolic components, particularly hydroxytyrosol (HT). HT potent antioxidant and anti-inflammatory actions have attracted researchers' attention and may contribute to neuroprotective effects credited to MD. In this review HT bioavailability and pharmacokinetics are presented prior to discussing health beneficial effects. In vitro and in vivo neuroprotective effects together with its multiple mechanisms of action are reviewed. Other microconstituents of olive oil are also considered due to their potential neuroprotective effects (oleocanthal, triterpenic acids). Finally, we discuss the potential role of HT as a therapeutic tool in the prevention of neurodegenerative diseases.
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, Barcelona 08003, Spain. mfito@imim.es.|Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, Barcelona 08003, Spain. mfito@imim.es.|CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), Santiago de Compostela 15706, Spain. mfito@imim.es.
authors.forename: Jose
authors.initials: J
authors.lastname: Rodríguez-Morató
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, Barcelona 08003, Spain. mara.dierssen@crg.eu.|Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, Barcelona 08003, Spain. mara.dierssen@crg.eu.|Cellular & Systems Neurobiology Research Group, Center of Genomic Regulation, Dr. Aiguader 88, Barcelona 08003, Spain. mara.dierssen@crg.eu.
authors.forename: Laura
authors.initials: L
authors.lastname: Xicota
authors.affiliation: CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), Santiago de Compostela 15706, Spain. mfito@imim.es.|Cardiovascular Risk and Nutrition Research Group, Epidemiology Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, Barcelona 08003, Spain. mfito@imim.es.
authors.forename: Montse
authors.initials: M
authors.lastname: Fitó
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, Barcelona 08003, Spain. mfarre@imim.es.|Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Barcelona 08193, Spain. mfarre@imim.es.
authors.forename: Magí
authors.initials: M
authors.lastname: Farré
authors.affiliation: Cellular & Systems Neurobiology Research Group, Center of Genomic Regulation, Dr. Aiguader 88, Barcelona 08003, Spain. mara.dierssen@crg.eu.|CIBER de Enfermedades Raras (CIBERER), Barcelona 08003, Spain. mara.dierssen@crg.eu.
authors.forename: Mara
authors.initials: M
authors.lastname: Dierssen
authors.affiliation: Human Pharmacology and Clinical Neurosciences Research Group, Neurosciences Research Program, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Dr. Aiguader 88, Barcelona 08003, Spain. rtorre@imim.es.|Department of Experimental and Health Sciences, Universitat Pompeu Fabra (CEXS-UPF), Dr. Aiguader 80, Barcelona 08003, Spain. rtorre@imim.es.|CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN, CB06/03/028), Santiago de Compostela 15706, Spain. rtorre@imim.es.
authors.forename: Rafael
authors.initials: R
authors.lastname: de la Torre
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001682:Biological Availability; D038441:Diet, Mediterranean; D006801:Humans; D066298:In Vitro Techniques; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D000069463:Olive Oil / Q000737:chemistry*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000069463:Olive Oil; C005975:3,4-dihydroxyphenylethanol; D010626:Phenylethyl Alcohol