title: Outcome of acute myeloid leukemia patients with pulmonary nodules of uncertain etiology receiving allogeneic hematopoietic progenitor cell transplant.
abstract: Pulmonary nodules (PNs) develop frequently in patients with acute myeloid leukemia (AML). They are of infectious or inflammatory origin. They pose potential challenges to successful hematopoietic progenitor cell (HPC) transplant as they may be niches for infection reactivation or sites susceptible to subsequent infections. We retrospectively analyzed the outcome of 20 AML patients with multiple PNs who underwent allogeneic HPC transplants (12 related, 8 unrelated). There were 13 males and seven females (median age 52 yrs). Nine patients were in CR1, seven in CR2, and four with residual disease. The median times from appearance of PNs and from last positive CT scans to transplant were three and two months, respectively. The median time from pretransplant CT scans to transplant was one month. Multiple PNs were still reported in 5/20 of the pretransplant scans. The PNs in all five patients did not worsen after transplant. Four patients (one with positive pretransplant CT scan) died within the first 100 d after transplant, but none from primary pulmonary pathology. The median survival of this group of patients was 350 d. Our results, therefore, suggest that multiple PNs of uncertain etiology in patients with AML do not impact adversely on the outcome of allogeneic HPC transplant.
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Sara J
authors.initials: SJ
authors.lastname: Lim
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Lim
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Anastasios
authors.initials: A
authors.lastname: Raptis
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Jing-Zhou
authors.initials: JZ
authors.lastname: Hou
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Rafic
authors.initials: R
authors.lastname: Farah
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Stanley
authors.initials: S
authors.lastname: Marks
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Annie
authors.initials: A
authors.lastname: Im
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Dorritie
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Sehgal
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Mounzer
authors.initials: M
authors.lastname: Agha
authors.affiliation: Adult Hematopoietic Stem Cell Transplant Program, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Seah H
authors.initials: SH
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000401:mortality / Q000473:pathology / Q000628:therapy; D015996:Survival Rate
keywords: acute myeloid leukemia; pulmonary nodules; transplant outcome