title: A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition.
abstract: A flow injection analysis-quartz crystal microbalance (FIA-QCM) biosensor was developed for probing the dynamic interactions during protease inhibition. Being sensitive to conformation features of different proteases, this continuous-flow sensor has potential for structural-functional analysis and inhibitor selection.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. zhaorui@iccas.ac.cn.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Huang
authors.forename: Qundan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guoquan
authors.initials: G
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D017022:Flow Injection Analysis; D007700:Kinetics; D008958:Models, Molecular; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism*; D011480:Protease Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases