title: Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer.
abstract: OBJECTIVE
  Metastasis-associated in colon cancer-1 (MACC1), a new gene associated with primary and metastatic colon cancer, promotes tumor cell growth as well as the development of distant metastasis. The aim of this study is to investigate the expression of MACC1 protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis.
  
  
  METHODS
  Expression of MACC1 protein was detected immunohistochemically in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between MACC1 protein expression and clinicopathological parameters, postoperative liver metastasis were analyzed.
  
  
  RESULTS
  Immunohistochemistry examination showed that MACC1 protein expression was significantly more abundant in colon cancer tissues than in normal colon tissues (P = 0.038), Positive rate of MACC1 expression in colon cancer tissues was increased significantly in patients with lymph node metastases (P = 0.001) and higher T stages (P = 0.006). Postoperative live metastasis-free survival period was significantly longer in negative MACC1 expression group than that of positive MACC1 expression group (36.4 ± 2.85 vs. 28.6 ± 2.02 months, P = 0.014). Multivariate analysis showed that MACC1 expression level is an independent prognostic factor for postoperative live metastasis-free survival (95% confidence interval [CI] =1.32-3.38, P = 0.006).
  
  
  CONCLUSIONS
  Our results suggest that MACC1 expression level might play an important role in colon cancer invasion and MACC1 expression level is an independent biomarker for postoperative liver metastasis in patients with colon cancer.
authors.affiliation: Department of General Surgery, Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Ge
authors.affiliation: Department of General Surgery, Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Meng
authors.affiliation: Department of General Surgery, Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Jianliang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Second Hospital of Shandong University Jinan 250033, China.
authors.forename: Yinlu
authors.initials: Y
authors.lastname: Ding
keywords: Colon neoplasm; liver metastasis; metastasis-associated in colon cancer 1