title: Spontaneous regeneration capacity of controlled small bowel perforations: an experimental study in rats.
abstract: BACKGROUND
  Selective observation method has started to replace routine laparotomy application for abdominal penetrating trauma patients after Shaftan's selective observation method applied in the 1960s. In this respect, there is a possibility of bowel perforations healing without operations. An experimental model was established in this study in order to clarify this possibility.
  
  
  METHODS
  Fifty Wistar-Albino rats were divided into five groups, ten in each. While one group served as the control, distal part of the small bowel of the rats in the other four groups was perforated 1, 2, 3, and 4 mm in diameter with appropriate cutters. After a week of observation, test rats were sacrificed and relaparotomy was applied. The test material consisting of the perforated bowel, covering 1 cm of proximal and distal margins, and some peritoneal tissue was taken for histopathological examination.
  
  
  RESULTS
  Small bowel perforations with a diameter of 2 mm or below healed spontaneously without any operation. Peritonitis intensity increased in direct ratio with perforation diameters. Wall repair capacity of the bowel diminished with increasing perforation diameters.
  
  
  CONCLUSIONS
  It was observed that small perforations in the small bowel of rats could be limited by the organism itself without a necessity of any surgical intervention.
authors.affiliation: Department of General Surgery Unit, Sevket Yilmaz Training and Research Hospital, Bursa, Turkey. hamitsinanh@gmail.com.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Pekel
authors.affiliation: Department of General Surgery Unit, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Hatipoglu
authors.affiliation: Department of General Surgery Unit, Istanbul Cerrahi Hospital, Istanbul, Turkey.
authors.forename: Ahmet Nuray
authors.initials: AN
authors.lastname: Turhan
authors.affiliation: Department of Obstetrics and Gynecology Unit, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.
authors.forename: Filiz
authors.initials: F
authors.lastname: Hatipoglu
authors.affiliation: Department of Anesthesiology and Reanimation Unit, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.
authors.forename: Ruslan
authors.initials: R
authors.lastname: Abdullayev
authors.affiliation: Department of Pathology Unit, Acibadem (Maslak) Hospital, Istanbul, Turkey.
authors.forename: Süha
authors.initials: S
authors.lastname: Göksel
mesh_terms: D000007:Abdominal Injuries / Q000150:complications / Q000601:surgery*; D000818:Animals; D004195:Disease Models, Animal; D007416:Intestinal Perforation / Q000150:complications / Q000601:surgery*; D007421:Intestine, Small / Q000293:injuries / Q000601:surgery*; D007813:Laparotomy; D008297:Male; D010538:Peritonitis / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D014945:Wound Healing