title: Downregulation of ring-finger protein 43 in glioma associates with poor prognosis.
abstract: Ring-finger protein 43 (RNF43) has been identified as a RING-type E3 ubiquitin ligase. The overexpression of RNF43 results in a significant enhancement of cell growth, and knockdown of the expression of RNF43 by siRNAs exerts a growth-suppressing effect. RNF43 has been proposed as a tumor suppressor in colorectal cancers. However, its expression significance in glioma has not been well studied. In the present study, we found that the decreased expression of RNF43 was associated with poor prognosis by the Kaplan-Meier survival analysis (P < 0.001). Importantly, multivariate analysis suggested RN43 as an independent predictor of overall survival ([hazard ratio (HR) 0.547, 95% confidence interval (95% CI) 0.382-0.784, P = 0.001]). Collectively, our study demonstrated that RNF43 could be served as a potential prognostic marker for patients with this deadly disease.
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Xi
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Xinke
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pediatric Surgery, The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China.
authors.forename: Huadong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Pediatric Surgery, The First Affiliated Hospital, Sun Yat-sen University Guangzhou, China.
authors.forename: Zhihai
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Wanming
authors.initials: W
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Qiuliang
authors.initials: Q
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center Guangzhou, China ; Department of Pathology, Sun Yat-Sen University Cancer Center Guangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zeng
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D015996:Survival Rate; D044767:Ubiquitin-Protein Ligases
chemical_list: D004268:DNA-Binding Proteins; D015513:Oncogene Proteins; C496945:RNF43 protein, human; D044767:Ubiquitin-Protein Ligases
keywords: Ring-finger protein 43 (RNF43); glioma; prognostic marker; survival