title: Clinical variables associated with disability in leprosy cases in northeast Brazil.
abstract: BACKGROUND
  The clinical outcomes of leprosy include complications such as physical disabilities and deformities that vary according to the degree of impairment of nerve trunks. Knowledge of the factors that lead to the development of these complications is important for disability prevention programs. This study aimed to evaluate clinical factors associated with the occurrence of physical disability in leprosy cases.
  
  
  METHODS
  This was a retrospective study of 2,358 cases of leprosy in Aracaju, northeast Brazil, between 2001 and 2011. Analysis was done using the Chi-square test and logistic regression model.
  
  
  RESULTS
  Significant factors associated with disability were found to be male gender, having more than two affected nerves, multibacillary leprosy classification, leprosy reaction, and lepromatous leprosy. The multivariate analysis revealed that the associated factors included having more than two affected nerves, leprosy reaction (adjusted odds ratio [aOR]: 2.02, 95% confidence interval [CI]: 1.36 to 3.01), the multibacillary form (aOR: 2.74, 95% CI: 1.84 to 4.08), and lepromatous leprosy (aOR: 4.87, 95% CI: 2.86 to 16.08).
  
  
  CONCLUSIONS
  The number of affected nerves, leprosy reaction, operational classification, and clinical presentation were identified as the main factors associated with the development of disability in leprosy patients.
authors.affiliation: Postgraduate Program in Health Sciences, Federal University of Sergipe, Brazil. santosvictor19@gmail.com.
authors.forename: Victor Santana
authors.initials: VS
authors.lastname: Santos
authors.forename: Andressa Mayara Santos
authors.initials: AM
authors.lastname: de Matos
authors.forename: Lorena Sheila Alves
authors.initials: LS
authors.lastname: de Oliveira
authors.forename: Ligia Mara Dolce
authors.initials: LM
authors.lastname: de Lemos
authors.forename: Ricardo Queiroz
authors.initials: RQ
authors.lastname: Gurgel
authors.forename: Francisco Prado
authors.initials: FP
authors.lastname: Reis
authors.forename: Vanessa Tavares de Gois
authors.initials: VT
authors.lastname: Santos
authors.forename: Vera Lúcia Corrêa
authors.initials: VL
authors.lastname: Feitosa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D002648:Child; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult