title: A comparative and evaluative study of two cytological grading systems in breast carcinoma with histological grading: an important prognostic factor.
abstract: OBJECTIVE
  Cytonuclear gradings in the breast carcinoma raise the level of FNA reportage and improves patient management. Our aim was to evaluate and compare two cytological grading methods (Robinson's and Mouriquand's) in breast carcinoma and correlate it with Nottingham modification of Scarff-Bloom-Richardson (SBR) histological grading.
  
  
  METHODS
  30 cytologically proven cases of infiltrating ductal carcinoma were graded cytologically and histologically. Cytograding was done by Robinson's and Mouriquand's methods (grades I to III) followed by comparison of the two methods. Cytogradings were correlated with SBR grading method. Sensitivity, specificity, diagnostic accuracy, and concordance and discordance rates were evaluated.
  
  
  RESULTS
  An overall concordance of 76.66% between cytogradings, of 83.33% between Robinson's method and SBR, and of 66.66% between Mouriquand's method and SBR was seen. Robinson's method correlated best with SBR in all the three nuclear grades. Robinson's method showed a diagnostic accuracy of 90% with 91.30% sensitivity while Mouriquand's method had an accuracy of 76.66% with 95.65% sensitivity. The specificity by Mouriquand's method was quite low (14.28%) as compared to Robinson's method (85.71%).
  
  
  CONCLUSIONS
  Comprehensive cytological grading of breast cancer by Robinson's method seems better because of more objective set of criteria, easy reproducibility, and specificity.
authors.affiliation: Department of Pathology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India.
authors.forename: Pinki
authors.identifier: 0000-0002-8521-7588
authors.initials: P
authors.lastname: Pandey
authors.affiliation: Department of Pharmacology, U. P. Rural Institute of Medical Sciences & Research, Saifai, Etawah 206301, India.
authors.forename: Alok
authors.initials: A
authors.lastname: Dixit
authors.affiliation: Department of Pathology, RML Institute of Medical Sciences, Lucknow, India.
authors.forename: Subrat
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Department of Pathology, BPS Medical College, Khanpur, Sonepat, Haryana, India.
authors.forename: Swarn
authors.initials: S
authors.lastname: Kaur
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D060787:Neoplasm Grading / Q000379:methods*; D011379:Prognosis; D011446:Prospective Studies