title: Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) results from reduced complement regulatory proteins on hematopoietic cells, predisposing patients to intravascular hemolysis, thrombophilia, and cytopenias. Women diagnosed in pregnancy can experience significant maternofetal complications. Trials of eculizumab in PNH excluded pregnant women. Here, we report the first Canadian patient taken through pregnancy on eculizumab.
authors.affiliation: Division of Hematology & Thromboembolism, Department of Medicine, Juravinski Hospital and Cancer Centre 711 Concession Street, Hamilton, Ontario, Canada, L8V1C3.
authors.forename: Christopher
authors.initials: C
authors.lastname: Patriquin
authors.affiliation: Division of Hematology & Thromboembolism, Department of Medicine, Juravinski Hospital and Cancer Centre 711 Concession Street, Hamilton, Ontario, Canada, L8V1C3.
authors.forename: Brian
authors.initials: B
authors.lastname: Leber
keywords: Aplastic anemia; PNH; eculizumab; hemolysis; pregnancy