title: Effectiveness of dietary allergen exclusion therapy on eosinophilic colitis in Chinese infants and young children ≤ 3 years of age.
abstract: Eosinophilic colitis is a well recognized clinical entity mainly associated with food allergies. Empiric treatment options include dietary allergen exclusion (extensively hydrolyzed protein formula and elimination diet), anti-allergy medications (antihistamines and leukotriene receptor antagonists) and corticosteroids. We evaluated the effectiveness of dietary antigen exclusion on clinical remission of eosinophilic colitis in infants and young children. We retrospectively reviewed charts of all infants and children ≤3 years of age who were diagnosed with eosinophilic colitis (defined as mucosal eosinophilia ≥20 hpf-1) from 1 January 2011 to 31 December 2013 at a tertiary children's hospital in China. Forty-nine children were identified with eosinophilic colitis. Elemental formula, simple elimination diet or combination therapy resulted in clinical improvement in 75%, 88.2% and 80% of patients, respectively. In conclusion, eosinophilic colitis in infants and children ≤3 years of age responded well to dietary allergen exclusion.
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. 273459720@qq.com.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. genglan_2001@hotmail.com.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Geng
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. chenpei.y@163.com.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Pathology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. wangfhua@163.com.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. xuer_hui@126.com.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. 172262276@qq.com.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. Lookfory@hotmail.com.
authors.forename: Huiwen
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. fangtf@126.com.
authors.forename: Tiefu
authors.initials: T
authors.lastname: Fang
authors.affiliation: Division of Gastroenterology, Children's Mercy Hospitals and Clinics, Kansas City 64108, MO, USA. cfriesen@cmh.edu.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Friesen
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. sitangg@126.com.
authors.forename: Sitang
authors.initials: S
authors.lastname: Gong
authors.affiliation: Division of Gastroenterology, Children's Mercy Hospitals and Clinics, Kansas City 64108, MO, USA. dyli@cmh.edu.
authors.forename: Dingyou
authors.initials: D
authors.lastname: Li
mesh_terms: D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D002675:Child, Preschool; D002681:China; D003092:Colitis / Q000178:diet therapy* / Q000209:etiology / Q000276:immunology; D003106:Colon / Q000276:immunology / Q000473:pathology*; D004802:Eosinophilia / Q000178:diet therapy* / Q000209:etiology; D057765:Eosinophilic Esophagitis; D004804:Eosinophils / Q000378:metabolism*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications / Q000178:diet therapy / Q000378:metabolism; D012189:Retrospective Studies
chemical_list: D000485:Allergens