title: Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus.
abstract: Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. To our knowledge, this is the first report of signet-ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet-ring cell changes in primary cutaneous tumors.
authors.affiliation: Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
authors.forename: Emilie
authors.initials: E
authors.lastname: Dore
authors.affiliation: Department of Dermatology, University of Iowa, Iowa City, IA, USA.
authors.forename: Megan H
authors.initials: MH
authors.lastname: Noe
authors.affiliation: Department of Dermatology, University of Iowa, Iowa City, IA, USA.|Department of Pathology, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, IA, USA.
authors.forename: Brian L
authors.initials: BL
authors.lastname: Swick
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D003537:Cystadenoma / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D018294:Neoplasms, Adnexal and Skin Appendage / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D054000:Nevus, Sebaceous of Jadassohn / Q000473:pathology*; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000473:pathology*
keywords: adnexal neoplasm; cutaneous adnexal neoplasms; cutaneous neoplasm; nevus sebaceus; skin tumors