title: [Liver and spleen biometrics in childhood-onset systemic lupus erythematosus patients].
abstract: OBJECTIVE
  To evaluate liver and spleen dimensions in childhood-onset systemic lupus erythematosus (c-SLE) patients and healthy controls.
  
  
  METHODS
  30 c-SLE patients and 30 healthy control volunteers underwent abdominal ultrasound. The following two liver measurements were performed in left hepatic lobe: craniocaudal and anteroposterior and three in right hepatic lobe (RHL): posterior craniocaudal (PCC-RHL), anterior craniocaudal and anteroposterior. Three spleen dimension measurements were also evaluated: longitudinal, transverse and anteroposterior. Demographic, clinical and laboratorial data, SLEDAI-2K, ECLAM, SLAM and treatment were assessed.
  
  
  RESULTS
  Mean current age was similar in c-SLE and controls (170.31 ± 27.81 vs. 164.15 ± 39.25 months; p = 0.486). The mean of PCC-RHL dimension was significantly higher in c-SLE compared to controls (13.30 ± 1.85 vs. 12.52 ± 0.93, p = 0.044). There were no differences between the other hepatic biometrics and splenic parameters (p > 0.05). Further analysis in c-SLE patients according to PCC-RHL dimension ≥ 13.3cm versus < 13.3 cm showed that the median of SLEDAI-2K [8(0-18) vs. 2(0-8), p=0.004], ECLAM [4(0-9) vs. 2(0-5), p = 0.019] and SLAM [5(1-13) vs. 2(0-14), p = 0.016] were significantly higher in patients with higher PCC-RHL dimension, likewise the frequencie of nephritis (77% vs. 29%, p = 0.010). Liver enzymes were similar in both groups (p > 0.05). Positive correlation was observed between SLEDAI-2K and PCC-RHL (p = 0.001, r = +0.595). Negative correlation was evidenced between disease duration and longitudinal dimension of spleen (p = 0.031, r = -0.394).
  
  
  CONCLUSIONS
  Our data raises the possibility that disease activity could lead to a subclinical and localized hepatomegaly during the disease course. Long disease duration resulted to spleen atrophy in c-SLE patients.
authors.affiliation: Unidade de Reumatologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil; Unidade de Reumatologia Pediátrica, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brasil.
authors.forename: Andressa
authors.initials: A
authors.lastname: Guariento
authors.affiliation: Unidade de Reumatologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marco Felipe C
authors.initials: MF
authors.lastname: Silva
authors.affiliation: Unidade de Reumatologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Priscilla S F
authors.initials: PS
authors.lastname: Tassetano
authors.affiliation: Unidade de Radiologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Sílvia Maria S
authors.initials: SM
authors.lastname: Rocha
authors.affiliation: Unidade de Reumatologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Lúcia M A
authors.initials: LM
authors.lastname: Campos
authors.affiliation: Unidade de Radiologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Valente
authors.affiliation: Unidade de Reumatologia Pediátrica, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil; Departamento de Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. Electronic address: clovisaasilva@gmail.com.
authors.forename: Clovis A
authors.initials: CA
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D001699:Biometry; D003430:Cross-Sectional Studies; D005260:Female; D006529:Hepatomegaly / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D013154:Spleen / Q000000981:diagnostic imaging*; D013163:Splenomegaly / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography
keywords: Atrofia do baço; Biometria; Biometry; Hepatomegalia; Hepatomegaly; Lúpus eritematoso sistêmico; Pediatric rheumatology; Reumatologia pediátrica; Spleen atrophy; Systemic lupus erythematosus; Ultrasound; Ultrassonografia