title: New anti-angiogenic leading structure discovered in the fruit of Cimicifuga yunnanensis.
abstract: Cimyunnins A-C (1-3), characterized with an unusual fused cyclopentenone ring G, together with cimyunnin D (4), possessing a highly rearranged γ-lactone ring F, were characterized from the fruit of Cimicifuga yunnanensis. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and density functional theory calculations. In addition, cimyunnin A exhibited comparable anti-angiogenic activities to those of sunitinib, a clinically-used first-line angiogenesis inhibitor, in the in vitro and ex vivo studies.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Nian
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Laboratory of Molecular Genetics of Aging &Tumor, Faculty of Medicine, Kunming University of Science &Technology, Kunming. 650500, P. R. China.
authors.forename: Tong-Yang
authors.initials: TY
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Genetics of Aging &Tumor, Faculty of Medicine, Kunming University of Science &Technology, Kunming. 650500, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Laboratory of Molecular Genetics of Aging &Tumor, Faculty of Medicine, Kunming University of Science &Technology, Kunming. 650500, P. R. China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D031885:Cimicifuga / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D040301:Vascular Endothelial Growth Factor Receptor-2