title: Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa.
abstract: Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showed good cytotoxicity against KB cell with IC50 values of 7.97 and 9.10μM, respectively. On the other hand, compound 15 showed good cytotoxicity against HeLa cell with IC50 value of 9.34μM.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Sutin
authors.initials: S
authors.lastname: Kaennakam
authors.affiliation: Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siripong
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address: Santi.Ti@chula.ac.th.
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-Pyang
mesh_terms: D002460:Cell Line; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010936:Plant Extracts; D044004:Xanthones; C000598396:kaennacowanol A; C000598397:kaennacowanol B; C000598398:kaennacowanol C
keywords: Clusiaceae; Cytotoxicity; Garcinia cowa; Kaennacowanols A–C; Xanthone