title: Magnesium with micro-arc oxidation coating and polymeric membrane: an in vitro study on microenvironment.
abstract: Numerous modification methods have been reported to enhance the corrosion resistance of magnesium with positive results. However, little attention has been paid on their impact on micro-environment, particularly the ion concentration and local pH value. In this study, two different coatings were prepared on magnesium, one with porous micro-arc oxidation (MAO) coating alone, and the other with additional polymer polyhydroxybutyrate (PHB) membrane using spinning technique. Their in vitro corrosional and biological behaviors were investigated and compared. Both coatings were found to reduce the degradation rate of magnesium, but an additionally deposited PHB membrane was superior to MAO-coated magnesium since it could produce a micro-environment with preferable local pH value and ion concentration for osteoblast proliferation. Our study suggests that micro-environment should be another critical issue in evaluation of a modification method for orthopaedic implants.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
authors.forename: Honglong
authors.initials: H
authors.lastname: Li
authors.forename: Haobo
authors.initials: H
authors.lastname: Pan
authors.forename: Chengyun
authors.initials: C
authors.lastname: Ning
authors.forename: Guoxin
authors.initials: G
authors.lastname: Tan
authors.forename: Jingwen
authors.initials: J
authors.lastname: Liao
authors.forename: Guoxin
authors.initials: G
authors.lastname: Ni
mesh_terms: D016475:3T3 Cells; D000818:Animals; D020099:Coated Materials, Biocompatible; D066298:In Vitro Techniques; D008274:Magnesium / Q000737:chemistry*; D008567:Membranes, Artificial; D051379:Mice; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011108:Polymers; D008274:Magnesium