title: Calcium homeostasis in cancer: A focus on senescence.
abstract: Senescence is one of the primary responses to the activation of oncoproteins or down-regulation of tumor suppressors in normal cells and is therefore considered as being anti-tumorigenic but the mechanisms controlling this process are still much unknown. Calcium (Ca²⁺) plays a major role in many cellular processes and calcium channels control many of the "hallmarks of cancer" but their involvement in tumor initiation is poorly understood and remains unclear. Therefore, in this article we review some striking senescence-associated characteristics and their potential regulation by Ca²⁺. The main aim is to produce plausible hypothesis on how calcium homeostasis may participate in cancer-related senescence. This article is part of a Special Issue entitled: 13th European Symposium on Calcium.
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq, 59656, France.
authors.forename: Valerio
authors.initials: V
authors.lastname: Farfariello
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq, 59656, France.
authors.forename: Oksana
authors.initials: O
authors.lastname: Iamshanova
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq, 59656, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Germain
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq, 59656, France.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Fliniaux
authors.affiliation: Inserm U1003, Laboratory of Excellence, Ion Channels Science and Therapeutics, Equipe Labellisée par la Ligue Nationale Contre le Cancer, SIRIC ONCOLille, Université de Lille 1-Sciences et Technologies, Villeneuve d'Ascq, 59656, France.
authors.forename: Natalia
authors.initials: N
authors.lastname: Prevarskaya
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D016922:Cellular Senescence; D006706:Homeostasis; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
keywords: Calcium channels; Calcium homeostasis; Cancer; Senescence