title: Production of No-Carrier Added Lutetium-177 by Irradiation of Enriched Ytterbium-176.
abstract: Two methods of Lu-177 production are reviewed: irradiation of isotopically enriched Lu- 176 (direct way) and irradiation of ytterbium enriched with Yb-176 (indirect way). Based on neutronphysical calculations Lu-177 yield and specific activity were estimated for both methods. Lu-177 specific activity strongly depends on neutron flux density in the direct way, that is 75,000 Ci/g for 10- days irradiation in a neutron flux of 2.10(15) cm(-2) s(-1), and only 13,000 Ci/g after 30 days irradiation at neutron flux 1.10(14) cm(-2) s(-1). Irradiation of Yb-176 provides Lu-177 specific activity close to theoretical value (110,000 Ci/g). Neutron flux density effect Lu-177 yield, that is 530 Ci/g for 2.1015 cm(-2) s(-1) neutron flux density after 30 days irradiation. A procedure of isolation and purification of Lu-177 from irradiated targets is described based on combination of galvanostatic extraction of ytterbium followed by cation-exchange chromatography from alfa-hydroxyisobutirate solutions on BioRad AG(®)50W-X8 resin.
authors.affiliation: Joint Stock Company "State Scientific Center - Research Institute of Atomic Reactors", Dimitrovgrad, Ul'yanovsk region, Russia, 433510. orip@niiar.ru.
authors.forename: Valery A
authors.initials: VA
authors.lastname: Tarasov
authors.forename: Oleg I
authors.initials: OI
authors.lastname: Andreev
authors.forename: Evgeny G
authors.initials: EG
authors.lastname: Romanov
authors.forename: Rostislav A
authors.initials: RA
authors.lastname: Kuznetsov
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Kupriyanov
authors.forename: Ivan V
authors.initials: IV
authors.lastname: Tselishchev
mesh_terms: D002852:Chromatography, Ion Exchange / Q000379:methods; D007554:Isotopes / Q000737:chemistry; D008187:Lutetium / Q000737:chemistry*; D009502:Neutrons; D011868:Radioisotopes / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D007554:Isotopes; D011868:Radioisotopes; D008187:Lutetium; D015018:Ytterbium