title: Relationship of fibroblast growth factor 23 and fetuin--A to coronary atherosclerosis.
abstract: BACKGROUND
  Serum fibroblast growth factor 23 (FGF-23) and fetuin-A are established predictors of morbidity and mortality due to cardiovascular disease. The objective of the present study is to evaluate the relationship between coronary artery disease (CAD) and serum concentrations of FGF-23 and fetuin-A.
  
  
  METHODS
  A total of 383 subjects who underwent coronary computed tomography angiography (CCTA) were included in the study. CCTA detected CAD in 208 patients; the rest of the patients had no detectable CAD.
  
  
  RESULTS
  Serum FGF-23 and fetuin-A levels were significantly increased in CAD patients compared to non-CAD patients (26.6±21.1pg/mL vs. 17.9±16.1pg/mL, p=0.001 and 826±350mg/L vs. 595±300mg/L, p<0.001, respectively). Serum FGF-23, fetuin-A, low-density lipoprotein (LDL)-cholesterol, and uric acid values were elevated in non-diabetic patients with CAD when compared to those without CAD. FGF-23, and fetuin-A were not significantly different in diabetic patients with CAD when compared to those without CAD. Using multivariate logistic regression analysis, we found that age, hypertension, LDL-Cholesterol, high-density lipoprotein (HDL)-Cholesterol, hs-CRP, uric acid, FGF-23 and fetuin-A levels were independently associated with the presence of CAD.
  
  
  CONCLUSIONS
  FGF-23 and fetuin-A were positively correlated with coronary atherosclerosis Similar trends were seen among diabetic patients, but this did not reach statistical significance. FGF-23 and fetuin-A could be used as novel risk markers of cardiovascular disease.
authors.affiliation: Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey. Electronic address: faith._akin@hotmail.com.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Celik
authors.affiliation: Department of Cardiology, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Altun
authors.affiliation: Department of Cardiology, Bağcılar Education and Research Hospital, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Ayca
authors.affiliation: Department of Biochemistry, Mehmet Akif Ersoy Chest and Cardiovascular Surgery Education and Research Hospital, Istanbul, Turkey.
authors.forename: Vesile Ornek
authors.initials: VO
authors.lastname: Diker
authors.affiliation: Department of Cardiology, Acıbadem University, Istanbul, Turkey.
authors.forename: Seckin
authors.initials: S
authors.lastname: Satılmıs
authors.affiliation: Department of Internal Medicine, Muğla Sıtkı Kocman University School of Medicine, Muğla, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Sahin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000097:blood / Q000453:epidemiology; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; C000717427:FGF23 protein, human; D008075:Lipoproteins, HDL; D060749:alpha-2-HS-Glycoprotein; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002097:C-Reactive Protein
keywords: Coronary atherosclerosis; Coronary computed tomography angiography; Diabetes mellitus; Fetuin-A; Fibroblast growth factor 23