title: MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer.
abstract: MicroRNAs (miRNAs) are aberrantly expressed in cervical cancer. miR-7 has been demonstrated to function as both an oncogene and a tumor suppressor in some types of human cancers. In the present study, miR-7 was significantly downregulated in cervical cancer, especially metastatic tumors. Ectopic expression of miR-7 significantly inhibited metastasis and invasion in Hela and C33A cells. Upregulated miR-7 significantly suppressed focal adhesion kinase (FAK) at transcriptional and translational levels. Furthermore, the level of FAK was negatively correlated with miR-7 in cervical cancer tissues. In conclusion, miR-7 inhibited the metastasis and invasion of cervical cancer at least partially through targeting FAK. The findings of this study provide novel insight with potential therapeutic applications for the treatment of metastatic cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Taixing People's Hospital Affiliated to Yangzhou University Taizhou 225004, Jiangshu, China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Hao
authors.affiliation: Department of Obstetrics and Gynecology, Taixing People's Hospital Affiliated to Yangzhou University Taizhou 225004, Jiangshu, China.
authors.forename: Jishi
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pathology, Medical College of Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Chenghai
authors.initials: C
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Intergrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Intergrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of Intergrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Obstetrics and Gynecology, Taixing People's Hospital Affiliated to Yangzhou University Taizhou 225004, Jiangshu, China.
authors.forename: Liulin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics and Gynecology, Taixing People's Hospital Affiliated to Yangzhou University Taizhou 225004, Jiangshu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, Medical College of Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Jiangsu Key Laboratory of Intergrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University Yangzhou 225001, Jiangshu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qian
keywords: cervical cancer; focal adhesion kinase; invasion; metastasis; miR-7; microRNA