title: Method for 3D airway topology extraction.
abstract: In lungs the number of conducting airway generations as well as bifurcation patterns varies across species and shows specific characteristics relating to illnesses or gene variations. A method to characterize the topology of the mouse airway tree using scanning laser optical tomography (SLOT) tomograms is presented in this paper. It is used to test discrimination between two types of mice based on detected differences in their conducting airway pattern. Based on segmentations of the airways in these tomograms, the main spanning tree of the volume skeleton is computed. The resulting graph structure is used to distinguish between wild type and surfactant protein (SP-D) deficient knock-out mice.
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany ; REBIRTH Cluster of Excellence, Hannover, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Grothausmann
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany ; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
authors.forename: Manuela
authors.initials: M
authors.lastname: Kellner
authors.affiliation: Biomedical Optics Department, Laser Zentrum Hannover e.V., Hannover, Germany.
authors.forename: Marko
authors.initials: M
authors.lastname: Heidrich
authors.affiliation: Biomedical Optics Department, Laser Zentrum Hannover e.V., Hannover, Germany.
authors.forename: Raoul-Amadeus
authors.initials: RA
authors.lastname: Lorbeer
authors.affiliation: Biomedical Optics Department, Laser Zentrum Hannover e.V., Hannover, Germany.
authors.forename: Tammo
authors.initials: T
authors.lastname: Ripken
authors.affiliation: Biomedical Optics Department, Laser Zentrum Hannover e.V., Hannover, Germany ; Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School, Hannover, Germany.
authors.forename: Heiko
authors.initials: H
authors.lastname: Meyer
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany ; REBIRTH Cluster of Excellence, Hannover, Germany ; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
authors.forename: Mark P
authors.initials: MP
authors.lastname: Kuehnel
authors.affiliation: Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany ; REBIRTH Cluster of Excellence, Hannover, Germany ; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ochs
authors.affiliation: REBIRTH Cluster of Excellence, Hannover, Germany ; Institut für Informationsverarbeitung, Leibniz University Hannover, Hannover, Germany.
authors.forename: Bodo
authors.initials: B
authors.lastname: Rosenhahn
mesh_terms: D000465:Algorithms; D000818:Animals; D001980:Bronchi / Q000502:physiology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008953:Models, Anatomic; D064847:Multimodal Imaging / Q000379:methods*; D055095:Optics and Photonics; D037663:Pulmonary Surfactant-Associated Protein D / Q000737:chemistry*; D014057:Tomography, X-Ray Computed / Q000379:methods; D014132:Trachea / Q000502:physiology
chemical_list: D037663:Pulmonary Surfactant-Associated Protein D