title: Magnetic property, DFT calculation, and biological activity of bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] complex.
abstract: The dinuclear complex bis[(μ(2)-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.
authors.affiliation: School of Pharmacy, Lebanese American University, Byblos, Lebanon.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mroueh
authors.affiliation: School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
authors.forename: Costantine
authors.initials: C
authors.lastname: Daher
authors.affiliation: School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
authors.forename: Essa
authors.initials: E
authors.lastname: Hariri
authors.affiliation: School of Arts and Sciences, Lebanese American University, Byblos, Lebanon.
authors.forename: Sally
authors.initials: S
authors.lastname: Demirdjian
authors.affiliation: Department of Physics, American University of Beirut, 11-0236 Beirut, Lebanon.
authors.forename: Samih
authors.initials: S
authors.lastname: Isber
authors.affiliation: National High Magnetic Field Lab, Florida, Tallahassee, FL 32310-3706, USA.
authors.forename: Eun Sang
authors.initials: ES
authors.lastname: Choi
authors.affiliation: Department of Chemistry, Faculty of Science, University of Qom, PO Box 37185-359, Qom, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Mirtamizdoust
authors.affiliation: Chemistry Department, Faculty of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia. Electronic address: hhammoud@kfu.edu.sa.
authors.forename: Hassan H
authors.initials: HH
authors.lastname: Hammud
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D054879:Halogenation; D006801:Humans; D060328:Magnetic Phenomena; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D010618:Phenanthrolines; D003300:Copper; C025205:1,10-phenanthroline
keywords: Anticancer; Copper(II) phenanthroline; DFT; In vitro cytotoxicity; Magnetism; Thermal