title: [Mucocutaneous diseases and murine models with death of keratinocytes induced by lichenoid tissue reaction/interface dermatitis].
abstract: A set of histopathological elements with death of epidermal basal cell layer keratinocytes along with inflammatory cell infiltration distinguishes lichenoid tissue reaction (LTR)/interface dermatitis (IFD) from other inflammatory mucocutaneous diseases. The LTR/IFD can be seen in skin disorders like as lichen planus, acute graft-versus-host disease, lupus erythematosus, dermatomyositis, and toxic epidermal necrolysis/Stevesn-Johnson syndrome. Clinical and basic researches suggested that cytotoxic CD8 T cells producing interferon-γ and FasL are final effector cells to cause apoptosis of keratinocyte. Some murine models of LTR/IFD have been established, for example, LTR/IFD reactions of keratinocyte-specific ovalbumin (OVA)-transgenic mice after OVA-specific T-cell-receptor(+)CD8 T cells. By analysis of the murine model, a new class of immunosuppressant, a JAK inhibitor, has been suggested as a new candidate for treatment of LTR/IFD.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tsukuba.
authors.forename: Naoko
authors.initials: N
authors.lastname: Okiyama
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003872:Dermatitis / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D053222:Fas Ligand Protein; D006801:Humans; D007371:Interferon-gamma; D015603:Keratinocytes / Q000276:immunology* / Q000473:pathology*; D017512:Lichenoid Eruptions / Q000276:immunology* / Q000473:pathology*; D010047:Ovalbumin / Q000276:immunology
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D007371:Interferon-gamma; D010047:Ovalbumin