title: [Peculiar features of forming radiation effects in inbred populations of Drosophila melanogaster differing in cytotype].
abstract: A comparative evaluation of the sensitivity of inbred wild-type flies differing in the cytotype to the action of low-intensity radiation of different duration was conducted taking into account the integral parameters of survival. The strong dependence of the frequency of radiation-induced DNA damage (in the neutralpH version) to the cells of individuals on the dose of low-intensity radiation and stages of spermatogenesis was established. The hyper-radiosensitivity was found in the individuals of Charolles (R-cytotype), Harwich (P-cytotype), and Oregon-R (H-cytotype) strains irradiated during the early stages of spermatogenesis (spermatogonia-spermatocytes) and containing in their genotype transposons Bari 1, P and hobo, respectively. While drosophila line Canton-S exhibited dysgenetic properties against the background of several cytotypes (E, I and M), the effect of hormesis was identified under the same experimental conditions. With the increase in the dose of low-intensity irradiation, the frequency of the DNA damage either increased (for Canton-S) or reduced (for Harwich and Charolles). At that, the profile of fertility and. survival of wild-type stocks studied was maintained at a significantly high level. The important role of the cytotype and mobile genetic elements responsible for its formation in the modification of the effects of low-intensity γ-radiation is shown.
authors.forename: E A
authors.initials: EA
authors.lastname: Iushkova
authors.forename: V G
authors.initials: VG
authors.lastname: Zaĭnullin
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects*; D004251:DNA Transposable Elements / Q000528:radiation effects; D004331:Drosophila melanogaster; D005298:Fertility / Q000528:radiation effects; D005720:Gamma Rays; D007178:Inbreeding; D008297:Male; D011836:Radiation Tolerance; D013090:Spermatocytes / Q000528:radiation effects*; D013091:Spermatogenesis / Q000528:radiation effects*
chemical_list: D004251:DNA Transposable Elements; D004247:DNA