title: Congenital microtia in a neonate due to maternal isotretinoin exposure 1 month before pregnancy: Case Report.
abstract: Isotretinoin is a drug used for treating severe cystic/nodular acne. Severe malformations have been documented in neonates whose mothers had taken isotretinoin during pregnancy. Women who became pregnant one cycle after completing therapy are believed to be at teratogenic risk not higher than baseline. We describe the case of a newborn whose mother had taken the drug for 4 weeks. The woman then had contraception for 4 weeks (after the drug treatment had finished), and became pregnant after that period. The newborn had isolated bilateral microtia due to suspected isotretinoin exposure. His mother also had a history of urine tract infection in the second week of pregnancy that was treated with cephalexin. The parents were not from a consanguineous marriage and had no family history of congenital malformations. To reduce the risk, effective contraception should be continued in fertile women more than 1 month after completing therapy.
authors.affiliation: Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.|Breast Feeding Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Shirazi
authors.affiliation: Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Ezzat
authors.initials: E
authors.lastname: Abbariki
authors.affiliation: Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Reihaneh
authors.initials: R
authors.lastname: Pirjani
authors.affiliation: Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Setareh
authors.initials: S
authors.lastname: Akhavan
authors.affiliation: Breast Feeding Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Dastgerdy
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced*; D001034:Apgar Score; D065814:Cerebellar Vermis / Q000002:abnormalities / Q000187:drug effects; D002585:Cesarean Section; D002946:Cisterna Magna / Q000002:abnormalities / Q000187:drug effects; D065817:Congenital Microtia / Q000139:chemically induced*; D003879:Dermatologic Agents / Q000633:toxicity*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007492:Iran; D015474:Isotretinoin / Q000633:toxicity*; D008297:Male; D008431:Maternal-Fetal Exchange; D006831:Polyhydramnios / Q000139:chemically induced / Q000503:physiopathology / Q000601:surgery; D011247:Pregnancy; D013723:Teratogens / Q000633:toxicity*; D047929:Term Birth
chemical_list: D003879:Dermatologic Agents; D013723:Teratogens; D015474:Isotretinoin
keywords: Accutane; congenital malformation; isotretinoin; microtia; teratogen