title: Antagomir-1290 suppresses CD133⁺ cells in non-small cell lung cancer by targeting fyn-related Src family tyrosine kinase.
abstract: Cancer stem-like cells (CSLCs) are involved in cancer initiation, development, and metastasis, and microRNAs (miRNAs) play pivotal roles in regulating CSLCs. miRNA-based therapeutic strategy associated with CSLCs might promise potential new therapeutic approaches. In the present study, we found that miR-1290 was increased in CD133(+) cells. Antagomir-1290 significantly suppressed tumor volume and weight initiated by CD133(+) cells in vivo. Furthermore, antagomir-1290 significantly inhibited the proliferation, clonogenicity, invasion, and migration of CD133(+) cells by targeting fyn-related Src family tyrosine kinase. These findings provide insights into the clinical prospect of miR-1290-based therapies for non-small cell lung cancer.
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 5 Dongdansantiao, Beijing, 100005, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.forename: Huifeng
authors.initials: H
authors.lastname: Zhang
authors.forename: Chunying
authors.initials: C
authors.lastname: Hou
authors.forename: Chao
authors.initials: C
authors.lastname: Ji
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Liu
authors.forename: Pingping
authors.initials: P
authors.lastname: Zuo
mesh_terms: D000071916:AC133 Antigen; D015703:Antigens, CD / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D009361:Neoplasm Invasiveness / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000473:pathology; D010455:Peptides / Q000235:genetics*; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D006023:Glycoproteins; C574604:MIRN1290 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; C000606023:PROM1 protein, human; D010455:Peptides; D011505:Protein-Tyrosine Kinases; C092830:FRK protein, human