title: Carcinoma ex-pleomorphic adenoma of the parotid gland consisting of high-grade salivary duct carcinoma and keratinizing squamous cell carcinoma.
abstract: Carcinoma ex-pleomorphic adenoma (CXPA) is a rare salivary gland malignancy that presents diagnostic difficulties partly because of its wide range of histologic presentations. We report a case of a 77-year-old man, who presented with a 6-year history of a parotid mass that had undergone rapid growth within weeks. Magnetic resonance imaging revealed an infiltrative mass in the parotid gland, and the fine-needle aspiration (FNA) biopsy result was highly suspicious for carcinoma. Subsequent excision of the tumor demonstrated a poorly differentiated epithelial neoplasm consisting of keratinizing squamous cell carcinoma (SCC) and adenocarcinoma with regions of both ductal carcinoma in situ and invasive salivary duct carcinoma (SDC). Only focal areas exhibited a benign pleomorphic adenoma component. To our knowledge, this is the first case of a CXPA that consists of both a high-grade SDC and a keratinizing SCC in the parotid gland.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA 90095, USA.
authors.forename: Shino D
authors.initials: SD
authors.lastname: Magaki
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA 90095, USA.
authors.forename: Sunita
authors.initials: S
authors.lastname: Bhuta
authors.affiliation: Division of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA 90095, USA.
authors.forename: Elliot
authors.initials: E
authors.lastname: Abemayor
authors.affiliation: Division of Head and Neck Surgery, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA 90095, USA.
authors.forename: Vishad
authors.initials: V
authors.lastname: Nabili
authors.affiliation: Department of Radiological Sciences, University of California, Los Angeles (UCLA) Medical Center, Los Angeles, CA 90095, USA.
authors.forename: Ali R
authors.initials: AR
authors.lastname: Sepahdari
authors.affiliation: Department of Pathology and Laboratory Medicine, Division of Anatomical Pathology, The Ottawa Hospital, Ottawa, Ontario K1H 8L6, Canada. Electronic address: Chilai@toh.on.ca.
authors.forename: Chi K
authors.initials: CK
authors.lastname: Lai
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010307:Parotid Neoplasms / Q000473:pathology*; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor