title: Muscle wasting in cancer: the role of mitochondria.
abstract: OBJECTIVE
  The aim of the present review is to examine the impact of mitochondrial dysfunction in cancer cachexia.
  
  
  RESULTS
  Oxidative pathways are altered in this tissue during muscle wasting and this seems to be a consequence of mitochondrial abnormalities that include altered morphology and function, decreased ATP synthesis and uncoupling.
  
  
  CONCLUSIONS
  An alteration of energy balance is the immediate cause of cachexia. Both alterations in energy intake and expenditure are responsible for the wasting syndrome associated with different types of pathological conditions, such as cancer. Different types of molecular mechanisms contribute to energy expenditure and, therefore, involuntary body weight loss, one of which is mitochondrial dysfunction.
authors.affiliation: aCancer Research Group, Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona bInstitut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain.
authors.forename: Josep M
authors.initials: JM
authors.lastname: Argilés
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Soriano
authors.forename: Silvia
authors.initials: S
authors.lastname: Busquets
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D004734:Energy Metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology*; D009133:Muscular Atrophy / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009369:Neoplasms / Q000150:complications*; D019282:Wasting Syndrome / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D015431:Weight Loss
chemical_list: D000255:Adenosine Triphosphate