title: Acute effects of an arginine-based supplement on neuromuscular, ventilatory, and metabolic fatigue thresholds during cycle ergometry.
abstract: The purpose of the present study was to examine the effects of an acute dose of an arginine-based supplement on the physical working capacity at the fatigue threshold (PWCFT), lactate threshold (LT), ventilatory threshold (VT), and peak oxygen uptake during incremental cycle ergometry. This study used a double-blinded, placebo-controlled, within-subjects crossover design. Nineteen untrained men (mean age ± SD = 22.0 ± 1.7 years) were randomly assigned to ingest either the supplement (3.0 g of arginine, 300 mg of grape seed extract, and 300 mg of polyethylene glycol) or placebo (microcrystalline cellulose) and performed an incremental test on a cycle ergometer for determination of PWCFT, LT, VT, and peak oxygen uptake. Following a 1-week period, the subjects returned to the laboratory and ingested the opposite substance (either supplement or placebo) prior to completing another incremental test to be reassessed for PWCFT, LT, VT, and peak oxygen uptake. The paired-samples t tests indicated there were significant (P < 0.05) mean differences between the arginine and placebo conditions for the PWCFT (192 ± 42 vs. 168 ± 53 W, respectively) and VT (2546 ± 313 vs. 2452 ± 342 mL·min(-1)), but not the LT (135 ± 26 vs. 138 ± 22 W), absolute peak oxygen uptake (3663 ± 445 vs. 3645 ± 438 mL·min(-1)), or relative peak oxygen uptake (46.5 ± 6.0 vs. 46.2 ± 5.0 mL·kg(-1)·min(-1)). These findings suggested that the arginine-based supplement may be used on an acute basis for delaying the onset of neuromuscular fatigue (i.e., PWCFT) and improving the VT in untrained individuals.
authors.affiliation: Department of Kinesiology, Mississippi State University, Mississippi State, MS 39762, USA.
authors.forename: Roksana B
authors.initials: RB
authors.lastname: Zak
authors.forename: Clayton L
authors.initials: CL
authors.lastname: Camic
authors.forename: Ethan C
authors.initials: EC
authors.lastname: Hill
authors.forename: Molly M
authors.initials: MM
authors.lastname: Monaghan
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Kovacs
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Wright
mesh_terms: D001120:Arginine / Q000008:administration & dosage*; D015992:Body Mass Index; D002482:Cellulose / Q000008:administration & dosage; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004576:Electromyography; D005080:Exercise Test; D005221:Fatigue / Q000188:drug therapy*; D056604:Grape Seed Extract / Q000008:administration & dosage; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption; D011092:Polyethylene Glycols / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D056604:Grape Seed Extract; D019344:Lactic Acid; D011092:Polyethylene Glycols; D002482:Cellulose; D001120:Arginine; C109691:microcrystalline cellulose
keywords: EMG; PWCFT; extrait de pépin de raisin; grape seed extract; nitric oxide; oxyde nitrique; polyethylene glycol; polyéthylèneglycol; supplements; suppléments