title: The hippocampus: A central node in a large-scale brain network for memory.
abstract: The medial temporal lobe is a key region in the formation and consolidation of conscious or declarative memories. In this review, we will first consider the role of the hippocampus and its surrounding medial temporal lobe structures in recognition memory from a historical perspective. According to the dual process model of recognition memory, recognition judgments can be based on the recollection of details about previous presented stimuli or on the feeling of familiarity. Studies in humans, primates and rodents suggest that the hippocampus, the parahippocampal cortex and the perirhinal cortex play different roles in recollection and familiarity. Then, we will describe the role of the hippocampus and neocortex in memory consolidation: a process in which novel memories become integrated into long-term memory. After presenting possible mechanisms underlying sleep-dependent declarative memory consolidation, we will discuss the phenomenon of accelerated long-term forgetting. This type of memory deficit is often observed in epileptic patients with a hippocampal lesion, and provides a novel opportunity to investigate post-encoding and memory consolidation processes.
authors.affiliation: EA 4072, laboratoire PSITEC, équipe « Neuropsychologie: Audition, Cognition, Action », université de Lille, rue Émile-Laine, 59037 Lille, France; Centre de neuro-imagerie de recherche (CENIR), groupe hospitalier de la Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France; Centre de recherche de l'institut du cerveau et de la moelle épinière (CRICM), UPMC-UMR 7225 CNRS - UMRS 975 Inserm, 47, boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Huijgen
authors.affiliation: EA 4072, laboratoire PSITEC, équipe « Neuropsychologie: Audition, Cognition, Action », université de Lille, rue Émile-Laine, 59037 Lille, France; Unité d'épilepsie, groupe hospitalier de la Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: severine.samson@univ-lille3.fr.
authors.forename: S
authors.initials: S
authors.lastname: Samson
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D019579:Neocortex / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D021641:Recognition, Psychology; D013702:Temporal Lobe / Q000502:physiology
keywords: Accelerated long-term forgetting; Consolidation; Familiarity; Familiarité; Gyrus parahippocampique; Hippocampe; Hippocampus; Long-term memory; Mémoire à long terme; Oublie à long terme accéléré; Parahippocampal gyrus; Recognition; Reconnaissance