title: Subcutaneous and total fat at L4-L5 and subcutaneous, visceral and total fat at L3-L4 are important contributors of fasting and postprandial adiponectin levels.
abstract: OBJECTIVE
  Insulin resistance and central obesity have been implicated in the pathogenesis of hypoadiponectinemia in obesity. The aim of this study is to evaluate circulating post-prandial adiponectin in relation to glucose and insulin metabolism, indexes of insulin resistance and sensitivity and, indexes of body fat accumulation and distribution in obese men.
  
  
  METHODS
  Twenty-eight non-diabetic men underwent an OGTT followed by an oral fat load and were studied at baseline and for 5 h post-prandially for serum adiponectin, glucose and insulin. Insulin resistance was estimated by Homeostasis model assessment (HOMA) and insulin sensitivity by Matsuda index. Body fat accumulation and distribution were evaluated by anthropometric indexes and multiple slices MRI of the abdomen and hip.
  
  
  RESULTS
  Adiponectin was negatively correlated to insulin levels. Fasting and area under the curve (AUC) adiponectin levels were negatively correlated to HOMA (both p < 0.01) and positively to Matsuda index (both p < 0.05). Negative correlations between fasting adiponectin and total fat (r = -0.408, p < 0.05), AUC adiponectin and subcutaneous, visceral and total fat (r = -0.375, -0.413 and -0.475 respectively, all p < 0.05) at L3-L4 were found, and negative correlations between fasting adiponectin and subcutaneous (r = -0.402, p < 0.05) and total fat (r = -0.491, p < 0.05) and between AUC adiponectin and subcutaneous and total fat (r = -0.506 and -0.547, respectively, both p < 0.01) were present at L4-L5.
  
  
  CONCLUSIONS
  Circulating adiponectin is inversely correlated to both visceral and subcutaneous fat in non-diabetic men, implying that both compartments are important for adiponectin levels. The best correlation is found at measurement site L4-L5.
authors.affiliation: Division of Endocrinology .
authors.forename: Simoni A
authors.initials: SA
authors.lastname: Katergari
authors.forename: Ploumis
authors.initials: P
authors.lastname: Passadakis
authors.forename: Athanasios
authors.initials: A
authors.lastname: Milousis
authors.forename: Theoktisti
authors.initials: T
authors.lastname: Passadaki
authors.forename: Byron
authors.initials: B
authors.lastname: Asimakopoulos
authors.forename: Michael
authors.initials: M
authors.lastname: Mantatzis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Prassopoulos
authors.forename: Grigorios
authors.initials: G
authors.lastname: Tripsianis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Nikolettos
authors.forename: Dimitrios N
authors.initials: DN
authors.lastname: Papachristou
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000502:physiology*; D000368:Aged; D001786:Blood Glucose; D005215:Fasting / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D050151:Subcutaneous Fat / Q000033:anatomy & histology*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin
keywords: Body fat distribution; diabetes mellitus type 2; insulin resistance; obesity; post-prandial