title: Dithiol-based modification of poly(dopamine): enabling protein resistance via short-chain ethylene oxide oligomers.
abstract: We present a facile strategy to modify poly(dopamine) (PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer. Surprisingly, dithiol-terminated OEG molecules demonstrated significantly greater coverage on PDA surfaces than analogous monothiol molecules. Successful RPA is only achieved with dithiol-terminated OEGs.
authors.affiliation: National Institute of Standards and Technology (NIST) Center for Neutron Research, Gaithersburg, Maryland 20899-8313, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Vaish
authors.forename: David J
authors.initials: DJ
authors.lastname: Vanderah
authors.forename: Lee J
authors.initials: LJ
authors.lastname: Richter
authors.forename: Michael
authors.initials: M
authors.lastname: Dimitriou
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Steffens
authors.forename: Marlon L
authors.initials: ML
authors.lastname: Walker
mesh_terms: D000327:Adsorption; D007211:Indoles / Q000737:chemistry*; D008958:Models, Molecular; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D007211:Indoles; D011108:Polymers; D011506:Proteins; C568283:polydopamine; D014050:Toluene; D011092:Polyethylene Glycols; C004848:dithiol