title: Assessment of sleep disturbances in patients with cancer: Cross-sectional study in a radiotherapy department.
abstract: OBJECTIVE
  To explore sleep-related problems reported by patients with cancer prior to undergoing radiotherapy, and to analyse the effect of cancer severity, history of treatment and psychosomatic symptomatology on these problems.
  
  
  METHODS
  A descriptive cross-sectional study was conducted. One hundred and five patients with cancer were evaluated prior to radiotherapy. The primary endpoint was the sleep problem score measured by a self-rated version of the Oviedo Sleep Questionnaire. Secondary variables were impact of pain on sleep, anxiety and asthenia.
  
  
  RESULTS
  Patients reported important levels of insomnia and hypersomnia. Insomnia-related problems were significantly higher in patients with more-severe disease (P < 0.05), and led to higher levels of hypnotic drug intake. Prior chemotherapy was significantly associated with hypersomnia-related problems (P < 0.05). Anxiety was significantly associated with both sleep-related problems.
  
  
  CONCLUSIONS
  Sleep problems are significant among patients with cancer prior to undergoing radiotherapy, and were found to be associated with progression of cancer, prior treatments and other psychosomatic symptoms (e.g. anxiety). Sleep problems within this context must be explored to provide adequate guidelines to palliate their effects on quality of life.
authors.affiliation: Radiotherapy and Oncology Department, ONCOSUR, Granada, Spain.
authors.forename: Escarlata
authors.initials: E
authors.lastname: López
authors.affiliation: Research Institute of Health Sciences, University of Balearic Islands, Palma de Mallorca, Spain. Electronic address: a.delatorre@uib.es.
authors.forename: Alejandro
authors.initials: A
authors.lastname: de la Torre-Luque
authors.affiliation: Radiotherapy and Oncology Department, ONCOSUR, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Lazo
authors.affiliation: Radiotherapy and Oncology Nursery Department, ONCOSUR, Granada, Spain.
authors.forename: Julia
authors.initials: J
authors.lastname: Álvarez
authors.affiliation: Psychophysiology Laboratory, Mind, Brain and Behaviour Research Centre, CIMCYC, Granada, Spain.
authors.forename: Gualberto
authors.initials: G
authors.lastname: Buela-Casal
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001007:Anxiety / Q000209:etiology*; D003430:Cross-Sectional Studies; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000523:psychology / Q000532:radiotherapy*; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000209:etiology*; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents; D006993:Hypnotics and Sedatives
keywords: Anxiety; Cancer; Hypnotics; Radiotherapy; Sleep problems