title: Malignant adenomyoepithelioma of the breast: a review.
abstract: Malignant adenomyoepithelioma (MAME) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46-year-old woman diagnosed by fine-needle aspiration with extensive review of the literature. Classification, clinical presentation, cyto-pathologic, and immunohistochemical features are described. This lesion showed both malignant components of epithelial and myoepithelial cells in cytology and histology. The malignancy was convincingly supported by high mitotic figures, pleomorphism, and invasion in tissue sections. This review of MAMEs showed that cyto-histologic diagnosis is difficult and should be supported by immunohistochemical study.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Ahmadi
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Negahban
authors.forename: Azita
authors.initials: A
authors.lastname: Aledavood
authors.forename: Khosrow
authors.initials: K
authors.lastname: Daneshbod
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
mesh_terms: D055331:Adenomyoepithelioma / Q000473:pathology*; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
keywords: cytology; fine-needle aspiration; histopathology; immunohistochemistry; literature review; malignant adenomyoepithelioma