title: [The expression of interleukin-25 in blood and nasal tissue of patients with chronic rhinosinusitis with nasal polyps].
abstract: OBJECTIVE
  To explore the expression of interleukin-25 (IL-25) in chronic rhinosinusitis with nasal polyps (CRSwNP) and its potential significance in pathogenesis.
  
  
  METHODS
  IL-25 expression in blood was detected by enzyme-linked immunosorbent assay (ELISA). IL-25 expression in tissue was detected by immunohistochemistry (LSAB method) from polyps (68 CRSwNP patients) and 55 inferior turbinate mucosa from patients with deviation of nasal septum served as control. Complete blood count and HE staining of blood and tissue eosinophil infiltration degree.
  
  
  RESULTS
  IL-25 expression in CRSwNP group were significantly higher than the control group, the difference was statistically significant (P < 0.01). IL-25 expression in local organizations was positively correlated with the number of eosinophil infiltration in CRSwNP group (r = 0.679, P < 0.01).
  
  
  CONCLUSIONS
  The expression of IL-25 in CRSwNP patients mutually reinforcing and might increase eosinophil infiltration and play an important role in the development of CRSwNP.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Gao
authors.forename: Jianting
authors.initials: J
authors.lastname: Wang
authors.forename: Hongying
authors.initials: H
authors.lastname: Zhao
authors.forename: Suliang
authors.initials: S
authors.lastname: Guo
authors.forename: Xiuxia
authors.initials: X
authors.lastname: Huang
mesh_terms: D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D009298:Nasal Polyps / Q000097:blood*; D009300:Nasal Septum; D012220:Rhinitis / Q000097:blood*; D012852:Sinusitis / Q000097:blood*; D014420:Turbinates
chemical_list: C486701:IL25 protein, human; D020381:Interleukin-17