title: Vitamin D analog EB1089 could repair the defective bone marrow-derived mesenchymal stromal cells in patients with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) involves multiple factors, which result in the breakdown of self-tolerance and development of autoimmunity with organ damage. Bone marrow mesenchymal stem cells (BMMSCs) from the patients with SLE showed an impaired proliferative capacity compared with that from normal controls. In this study, we isolated BMMSCs from the patients with SLE and found that Vitamin D analog EB1089 could induce BMMSCs proliferation and mineralization deposition. Furthermore, we found that the expression of p-Smad 1/5/8 was promoted in BMMSCs with EB1089 treatment. In conclusion, our results support the notion that EB1089 promoted proliferation and osteogenic differentiation of BMMSCs by Smad 1/5/8 signaling pathway.
authors.affiliation: Department of Rheumatology, Shengjing Hospital of China Medical University Sanhao Street 36, Heping District, Shenyang City 110004, Liaoning Province, P. R. China.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, First Hospital of China Medical University Nanjing North Street 155, Heping District, Shenyang City 110001, Liaoning Province, P. R. China.
authors.forename: Yan-Bin
authors.initials: YB
authors.lastname: Sun
authors.affiliation: Department of Rheumatology, Shengjing Hospital of China Medical University Sanhao Street 36, Heping District, Shenyang City 110004, Liaoning Province, P. R. China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology, Shengjing Hospital of China Medical University Sanhao Street 36, Heping District, Shenyang City 110004, Liaoning Province, P. R. China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Wang
keywords: EB1089; Smad signaling pathway; Systemic lupus erythematosus; bone marrow mesenchymal stem cells; proliferation