title: The effects of ankaferd blood stopper on the recovery process in an experimental oesophageal perforation model.
abstract: BACKGROUND
  Oesophageal perforation is a life-threatening pathology that is generally treated conservatively; however, surgical procedures are frequently performed. A topical haemostatic agent, Ankaferd Blood Stopper (ABS), also has beneficial wound-healing effects.
  
  
  OBJECTIVE
  This study aimed to determine the effects of ABS following experimental oesophageal perforations.
  
  
  METHODS
  Animal experiment.
  
  
  METHODS
  The experimental rats were classified into 6 groups (with 7 rats in each group). Pairs of groups (primary repair alone and primary repair + ABS) were terminated in the 1(st), 2(nd), and 3(rd) weeks following injury. The oesophageal perforations, which were 8-10 mm in length, were created using a nasogastric tube. The perforation sites were repaired with a 6-0 polyglactine thread in the primary repair groups. Additionally, ABS was sprayed over the perforation site in the treatment groups. Each oesophagus was evaluated histopathologically.
  
  
  RESULTS
  There were fewer microabscesses and areas of necrosis in the ABS groups compared with the primary repair groups. The histopathological evaluation revealed that the ABS groups had less inflammation and more re-epithelisation compared to the primary repair groups (p=0.002 and p=0.003, respectively). Fibrosis in the ABS groups was moderate in the 2(nd) week and mild in the 3(rd) week. Comparing the groups with respect to the time intervals, only the 1(st) week groups showed a significant difference in terms of re-epithelialisation (p=0.044).
  
  
  CONCLUSIONS
  Topical ABS application on the repaired experimental oesophageal perforation regions led to positive wound-healing effects compared with the rats that were administered the primary repair alone.
authors.affiliation: Department of Pediatric Surgery, Derince Training and Research Hospital, Kocaeli, Turkey.
authors.forename: Necla Gürbüz
authors.initials: NG
authors.lastname: Sarıkaş
authors.affiliation: Department of Emergency Medicine, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
authors.forename: Tanzer
authors.initials: T
authors.lastname: Korkmaz
authors.affiliation: Department of General Surgery, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Kahramansoy
authors.affiliation: Department of Thoracic Surgery, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Kılıçgün
authors.affiliation: Department of Pathology, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
authors.forename: Çetin
authors.initials: Ç
authors.lastname: Boran
authors.affiliation: Province Health Office, Bolu, Turkey.
authors.forename: Güledal
authors.initials: G
authors.lastname: Boztaş
keywords: Ankaferd Blood Stopper; experimental; oesophageal perforation