title: A potential peptide pathway from viruses to oral lichen planus.
abstract: Oral lichen planus is an idiopathic inflammatory disease of oral mucous membranes, characterized by an autoimmune epidermis attack by T cells. It remains unknown, however, how such aggressive T cells are activated in vivo to cause epidermal damage. This study analyzes the relationship at the peptide level between viruses and oral lichen planus disease. Four potentially immunogenic peptides (SSSSSSS, QEQLEKA, LLLLLLA, and MLSGNAG) are found to be shared between HCV, EBV, HHV-7, HSV-1, and CMV and three human proteins (namely pinin, desmoglein-3, and plectin). The described peptide sharing might be of help in deciphering the still unexplained immunopathogenic pathway that leads to oral lichen planus.
authors.affiliation: Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Second University of Naples (SUN), Napoli, Italy.
authors.forename: Alberta
authors.initials: A
authors.lastname: Lucchese
mesh_terms: D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000276:immunology; D003587:Cytomegalovirus / Q000737:chemistry; D051184:Desmoglein 3 / Q000737:chemistry / Q000276:immunology; D016174:Hepacivirus / Q000737:chemistry*; D006564:Herpesviridae / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000737:chemistry; D004854:Herpesvirus 4, Human / Q000737:chemistry; D016199:Herpesvirus 7, Human / Q000737:chemistry; D006801:Humans; D017676:Lichen Planus, Oral / Q000209:etiology* / Q000276:immunology; D009687:Nuclear Proteins / Q000737:chemistry / Q000276:immunology; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D051190:Plectin / Q000737:chemistry / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology*
chemical_list: D015815:Cell Adhesion Molecules; C071894:DSG3 protein, human; D051184:Desmoglein 3; D009687:Nuclear Proteins; C102646:PNN protein, human; D019151:Peptide Library; D010455:Peptides; D051190:Plectin; D014764:Viral Proteins
keywords: epitope; oral lichen planus; peptide; virus