title: A more flexible lipoprotein sorting pathway.
abstract: Lipoprotein biogenesis in Gram-negative bacteria occurs by a conserved pathway, each step of which is considered essential. In contrast to this model, LoVullo and colleagues demonstrate that the N-acyl transferase Lnt is not required in Francisella tularensis or Neisseria gonorrhoeae. This suggests the existence of a more flexible lipoprotein pathway, likely due to a modified Lol transporter complex, and raises the possibility that pathogens may regulate lipoprotein processing to modulate interactions with the host.
authors.affiliation: Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Chahales
authors.affiliation: Center for Infectious Diseases and Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA david.thanassi@stonybrook.edu.
authors.forename: David G
authors.initials: DG
authors.lastname: Thanassi
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D005604:Francisella tularensis / Q000201:enzymology* / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism*; D009344:Neisseria gonorrhoeae / Q000201:enzymology* / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D001426:Bacterial Proteins; D008074:Lipoproteins; D000217:Acyltransferases