title: Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature.
abstract: Spindle cell oncocytoma (SCO) of the adenohypophysis is a rare tumor in the sellar region. Due to its rarity, little information is available regarding SCO. It is often misdiagnosed as another type of sellar tumor. In the present study, two cases of SCO were reported. One patient was a 35-year-old female presenting with decreased visual acuity, amenorrhea and lactation. The other patient was a 62-year-old female with no clear symptoms or signs. Cranial magnetic resonance imaging (MRI) revealed a suprasellar mass with marked homogeneous enhancement in the two cases. A craniotomy was performed to completely resect the tumors. The tumors were immunopositive for vimentin, epithelial membrane antigen (EMA), S-100 and thyroid transcription factor-1 (TTF-1). The tumors were pathologically diagnosed as SCO. No recurrence occurred during the follow-up period of 15-21 months. In the present study, the literature was reviewed and the clinical data, imaging features, intraoperative findings and recurrence of 24 cases were analyzed in the literature as well as the present two cases. The average age of the SCO patients was 58.5 years and no gender preference was observed for the disease. The tumor exhibited homogeneous enhancement on the MRI. The intraoperative assessment revealed that the tumor had a rich blood supply and the SCO tumors were immunopositive for vimentin, S-100, EMA and TTF-1. These findings provided valuable clinical data for the preoperative diagnosis and surgical removal of SCO tumors.
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Mu
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Jinlu
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Pathology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Limei
authors.initials: L
authors.lastname: Qu
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Xitong
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Haijun
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zheng
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Yuxue
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
mesh_terms: D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018331:Nevus, Spindle Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010903:Pituitary Gland, Anterior / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011859:Radiography