title: Nerve guidance conduits from aligned nanofibers: improvement of nerve regeneration through longitudinal nanogrooves on a fiber surface.
abstract: A novel fibrous conduit consisting of well-aligned nanofibers with longitudinal nanogrooves on the fiber surface was prepared by electrospinning and was subjected to an in vivo nerve regeneration study on rats using a sciatic nerve injury model. For comparison, a fibrous conduit having a similar fiber alignment structure without surface groove and an autograft were also conducted in the same test. The electrophysiological, walking track, gastrocnemius muscle, triple-immunofluorescence, and immunohistological analyses indicated that grooved fibers effectively improved sciatic nerve regeneration. This is mainly attributed to the highly ordered secondary structure formed by surface grooves and an increase in the specific surface area. Fibrous conduits made of longitudinally aligned nanofibers with longitudinal nanogrooves on the fiber surface may offer a new nerve guidance conduit for peripheral nerve repair and regeneration.
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.|‡Department of Orthopaedic Surgery, the Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Ouyang
authors.affiliation: §Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Haitao
authors.initials: H
authors.lastname: Niu
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Nanfei
authors.initials: N
authors.lastname: He
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Qinfei
authors.initials: Q
authors.lastname: Ke
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Jin
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Fang
authors.affiliation: †Key Laboratory of Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
authors.forename: Wanjun
authors.initials: W
authors.lastname: Liu
authors.affiliation: ‡Department of Orthopaedic Surgery, the Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China.
authors.forename: Cunyi
authors.initials: C
authors.lastname: Fan
authors.affiliation: §Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
authors.forename: Tong
authors.initials: T
authors.lastname: Lin
mesh_terms: D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D048091:Guided Tissue Regeneration / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008422:Materials Testing; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure*; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020426:Sciatic Neuropathy / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D013499:Surface Properties; D054457:Tissue Scaffolds; D016896:Treatment Outcome
keywords: electrospinning; groove; nanofibers; nerve guidance conduit; nerve regeneration; tissue engineering