title: Hepatosplanchnic circulation in cirrhosis and sepsis.
abstract: Hepatosplanchnic circulation receives almost half of cardiac output and is essential to physiologic homeostasis. Liver cirrhosis is estimated to affect up to 1% of populations worldwide, including 1.5% to 3.3% of intensive care unit patients. Cirrhosis leads to hepatosplanchnic circulatory abnormalities and end-organ damage. Sepsis and cirrhosis result in similar circulatory changes and resultant multi-organ dysfunction. This review provides an overview of the hepatosplanchnic circulation in the healthy state and in cirrhosis, examines the signaling pathways that may play a role in the physiology of cirrhosis, discusses the physiology common to cirrhosis and sepsis, and reviews important issues in management.
authors.affiliation: Meghan Prin, Gebhard Wagener, Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, United States.
authors.forename: Meghan
authors.initials: M
authors.lastname: Prin
authors.affiliation: Meghan Prin, Gebhard Wagener, Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, United States.
authors.forename: Jan
authors.initials: J
authors.lastname: Bakker
authors.affiliation: Meghan Prin, Gebhard Wagener, Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, NY 10032, United States.
authors.forename: Gebhard
authors.initials: G
authors.lastname: Wagener
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D011169:Portal Vein / Q000503:physiopathology*; D011379:Prognosis; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D013152:Splanchnic Circulation
keywords: Hepatic artery buffer response; Hepatic circulation; Liver cirrhosis; Sepsis; Splanchnic circulation