title: [Pulmonary embolism in patients with cancer: foundations of the EPIPHANY study].
abstract: Pulmonary thromboembolism (PE) is a common cause of morbidity and mortality in patients with cancer. Having cancer is an independent risk factor for death in the general series of patients with PE and is included as a variable in the prognostic scales of acute symptomatic PE. This fact limits the discriminatory power of these general scales for patients with cancer and has prompted the development of specific prognostic tools: POMPE-C and a scale derived from the RIETE registry. Whether the increased risk of death by PE in patients with cancer is due to complications related to the neoplasm or to a greater severity of the thromboembolic episode in this population has not been well studied. Moreover, the introduction of computed multidetector tomography in recent years has led to a growing diagnosis of incidental PE, which currently represents up to half of pulmonary embolisms in patients with cancer. The EPIPHANY study attempts to further the understanding of the characteristics of pulmonary embolisms in patients with cancer by including incidental and symptomatic events. Its primary objectives are a) to understand the clinical and epidemiological patterns of pulmonary embolism associated with cancer and b) to develop and validate a specific prognosis model for PE in this population. The registry includes variables of interest to oncology (cancer type and extent, oncospecific treatments, patient's functional condition, cancer progression), radiological variables (thrombotic burden, signs of ventricular overload and other findings), location of treatment (hospital or outpatient), acute complications and causes of death in patients with PE associated with cancer.
authors.affiliation: Departamento de Oncología Médica, Hospital Clínic, Barcelona, España. Electronic address: CFONT@clinic.ub.es.
authors.forename: Carme
authors.initials: C
authors.lastname: Font
authors.affiliation: Departamento de Oncología Médica, Hospital Universitario Morales Meseguer, Murcia, España.
authors.forename: Alberto
authors.initials: A
authors.lastname: Carmona-Bayonas
authors.affiliation: Departamento de Radiodiagnóstico, Hospital Universitario Morales Meseguer, Murcia, España.
authors.forename: Juana M
authors.initials: JM
authors.lastname: Plasencia
authors.affiliation: Departamento de Radiodiagnóstico, Hospital Universitario Central de Asturias, Oviedo, España.
authors.forename: David
authors.initials: D
authors.lastname: Calvo-Temprano
authors.affiliation: Departamento de Radiodiagnóstico, Hospital Clínic, Barcelona, España.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Sánchez
authors.affiliation: Departamento de Oncología Médica, Hospital Universitario Central de Asturias, Oviedo, España.
authors.forename: Paula
authors.initials: P
authors.lastname: Jiménez-Fonseca
authors.affiliation: Departamento de Oncología Médica, Hospital Nisa Sevilla Aljarafe, Sevilla, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Beato
authors.affiliation: Departamento de Oncología Médica, Hospital Universitari Vall d'Hebron, Barcelona, España.
authors.forename: Mercè
authors.initials: M
authors.lastname: Biosca
authors.affiliation: Departamento de Oncología Médica, Hospital Universitario Morales Meseguer, Murcia, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Vicente
authors.affiliation: Departamento de Neumología, Hospital Universitario Virgen del Rocío (HUVR-IBiS), CIBERES, Sevilla, España.
authors.forename: Remedios
authors.initials: R
authors.lastname: Otero
mesh_terms: D002985:Clinical Protocols; D003661:Decision Support Techniques; D006801:Humans; D033162:Incidental Findings; D009369:Neoplasms / Q000150:complications*; D011379:Prognosis; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D012042:Registries; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain
keywords: Embolia incidental; Escalas pronosticas; Incidental pulmonary embolism; Prognostic scales; Pulmonary thromboembolism; Tromboembolia pulmonar