title: Drug design for neglected disease in Brazil.
abstract: Neglected tropical diseases (NTD) are a group of 17 diseases transmitted by virus, protozoa, helminthes and bacteria. These illnesses are responsible for millions of deaths per year, affecting mainly the poorest populations in the world. The therapeutic drugs available are obsolete, toxic, have questionable efficacy and there are reports of resistance. Therefore, the discovery of new, safe, effective and affordable active molecules is urgently needed. Considering that, the main purpose of this mini-review is to show the current scenario concerning drug design for neglected disease in Brazil. NTD are a very broad topic. Thus, we selected four infections for discussion: Chagas disease, leishmaniasis, malaria and tuberculosis. According to CNPq (National Counsel of Technological and Scientific Development) directories, there are many Brazilian groups studying these respective diseases. The papers published possess high quality and some of them, the most recent, are briefly discussed here. Medicinal chemistry approaches such as synthesis of novel series of molecules and biological activity evaluation, studies of structure-activity relationships (qualitative and quantitative), molecular modeling calculations and electrochemistry are some of the tools applied in the design of the compounds.
authors.forename: Jeanine
authors.initials: J
authors.lastname: Giarolla
authors.affiliation: Av. Prof. Lineu Prestes, 580 - Bloco 13 sup., Cidade Universitaria, Sao Paulo, SP 05508-900, Brasil. elizabeth.igne@gmail.com.
authors.forename: Elizabeth Igne
authors.initials: EI
authors.lastname: Ferreira
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001938:Brazil; D014355:Chagas Disease / Q000188:drug therapy; D002599:Chalcone / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy; D008288:Malaria / Q000188:drug therapy; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D058069:Neglected Diseases / Q000188:drug therapy*; D010271:Parasites / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000981:Antiprotozoal Agents; D000995:Antitubercular Agents; D002599:Chalcone