title: New antimicrobial bromotyrosine analogues from the sponge Pseudoceratina purpurea and its predator Tylodina corticalis.
abstract: Bioassay-guided fractionation of extracts from temperate Australian collections of the marine sponge Pseudoceratina purpurea resulted in the isolation and characterisation of two new and six known bromotyrosine-derived alkaloids with antibiotic activity. Surprisingly, a single specimen of the mollusc Tylodina corticalis, which was collected while feeding on P. purpurea, contained only a few of the compounds found in the sponge suggesting selective accumulation and chemical modification of sponge metabolites.
authors.affiliation: Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. michael.gotsbacher@sydney.edu.au.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Gotsbacher
authors.affiliation: Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. peter.karuso@mq.edu.au.
authors.forename: Peter
authors.initials: P
authors.lastname: Karuso
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D020387:Food Chain; D049851:Gastropoda / Q000378:metabolism; D011161:Porifera / Q000737:chemistry*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; C475724:bromotyrosine; D014443:Tyrosine