title: Detection rate of (99m) Tc-MIBI single photon emission computed tomography (SPECT)/CT in preoperative planning for patients with primary hyperparathyroidism: A meta-analysis.
abstract: Parathyroid scintigraphy using (99m) Tc-MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). The purpose of this review was to meta-analyze published data on the detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT.
  
  
  
  A comprehensive literature search of studies published through June 2014 was performed. The pooled detection rate of this scintigraphic method including 95% confidence intervals (95% CIs) was calculated on a per patient-based and on a per lesion-based analysis by using a random effects model.
  
  
  
  Twenty-three articles including 1236 patients with PHPT were selected. The pooled detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT was 88% (95% CI = 84% to 92%) and 88% (95% CI = 82% to 92%) on a per patient-based and per lesion-based analysis, respectively.
  
  
  
  The (99m) Tc-MIBI SPECT/CT has high detection rate for hyperfunctioning parathyroid glands in patients with PHPT. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2159-E2172, 2016.
authors.affiliation: Department of Nuclear Medicine, PET/CT and Thyroid Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Treglia
authors.affiliation: Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
authors.affiliation: Division of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Camilla
authors.initials: C
authors.lastname: Schalin-Jäntti
authors.affiliation: Institute of Nuclear Medicine, Catholic University, Rome, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Caldarella
authors.affiliation: Department of Nuclear Medicine, PET/CT and Thyroid Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
authors.forename: Luca
authors.initials: L
authors.lastname: Ceriani
authors.affiliation: Department of Nuclear Medicine, PET/CT and Thyroid Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
authors.forename: Luca
authors.initials: L
authors.lastname: Giovanella
authors.forename: David W
authors.initials: DW
authors.lastname: Eisele
mesh_terms: D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000000981:diagnostic imaging*; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D011300:Preoperative Care; D000072098:Single Photon Emission Computed Tomography Computed Tomography; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi
keywords: SPECT, SPECT/CT; hyperparathyroidism; parathyroid; scintigraphy; single photon emission computed tomography