title: A Clinical Trial with Brazilian Arnica (Solidago chilensis Meyen) Glycolic Extract in the Treatment of Tendonitis of Flexor and Extensor Tendons of Wrist and Hand.
abstract: One of the Brazilian arnicas, Solidago chilensis Meyen, is a species of the Asteraceae family. This plant is known by this common name because it shares remarkably similar organoleptic properties with the genus Arnica L., also within the family Asteraceae. We examined the effectiveness of the S. chilensis fluid extract used externally for treating tendinitis of flexor and extensor tendons of wrist and hand in placebo-controlled double-blind clinical pharmacological studies. This study was approved by the Ethical Committee for Scientific Research in Human Beings at University Vila Velha-UVV. Two daily skin applications on the arm skin of a gel cream containing a 5% glycolic plant extract were administered to eight volunteers for 21 days. Among the volunteers, one of their arms was used as the placebo group, and the other one was used as a test group. Statistical data analyses demonstrated a significant reduction in the perception of pain in the arms in the test group, when it was compared to those receiving only the placebo.
authors.affiliation: Laboratory of Functional Ecology, University of Vila Velha-UVV, Brazil.
authors.forename: Ary Gomes
authors.initials: AG
authors.lastname: da Silva
authors.affiliation: Department of Pharmacy, University of Vila Velha-UVV-ES, Brazil.
authors.forename: Elbe Rodrigues
authors.initials: ER
authors.lastname: Machado
authors.affiliation: Department of Pharmacy, University of Vila Velha-UVV-ES, Brazil.
authors.forename: Leonardo Mendes
authors.initials: LM
authors.lastname: de Almeida
authors.affiliation: Department of Pharmacy, University of Vila Velha-UVV-ES, Brazil.
authors.forename: Ricardo Marcelo Menezes
authors.initials: RM
authors.lastname: Nunes
authors.affiliation: Department of Physiotherapy, University of Vila Velha-UVV-ES, Brazil.
authors.forename: Patrícia Caldeira Pena
authors.initials: PC
authors.lastname: Giesbrecht
authors.affiliation: Doctoral Program in Biotechnology, Northeastern Web of Biotechnology-RENORBIO, Federal University of Espírito Santo-UFES, Brazil.
authors.forename: Regina Mamed
authors.initials: RM
authors.lastname: Costa
authors.affiliation: Petroleomic and Forensic Laboratory, Department of Chemistry, Federal University of Espírito Santo-UFES, Brazil.
authors.forename: Helber B
authors.initials: HB
authors.lastname: Costa
authors.affiliation: Petroleomic and Forensic Laboratory, Department of Chemistry, Federal University of Espírito Santo-UFES, Brazil.|Federal Institute of Espírito Santo, Vila Velha, IFES-ES, Brazil.
authors.forename: Wanderson
authors.initials: W
authors.lastname: Romão
authors.affiliation: Laboratory of Phytochemistry of Medicinal Plants, Institute of Natural Products Research, Federal University of Rio de Janeiro-IPPN-UFRJ, Brazil.
authors.forename: Ricardo Machado
authors.initials: RM
authors.lastname: Kuster
mesh_terms: D000279:Administration, Cutaneous; D001938:Brazil; D004311:Double-Blind Method; D005782:Gels; D006801:Humans; D010147:Pain Measurement; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D063465:Skin Cream; D036624:Solidago / Q000737:chemistry*; D052256:Tendinopathy / Q000188:drug therapy*; D013710:Tendons / Q000503:physiopathology; D014953:Wrist / Q000503:physiopathology
chemical_list: D005782:Gels; D010936:Plant Extracts
keywords: Asteraceae; antiinflammatory; antinociception activity; pain; phytotherapy; repetitive strain injury