title: Linifanib--a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator.
abstract: In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications.
authors.affiliation: School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. maria.marlow@nottingham.ac.uk.
authors.forename: Maria
authors.initials: M
authors.lastname: Marlow
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Ameedee
authors.forename: Thomas
authors.initials: T
authors.lastname: Smith
authors.forename: Simon
authors.initials: S
authors.lastname: Wheeler
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Stocks
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D007191:Indazoles / Q000737:chemistry* / Q000494:pharmacology*; D055595:Mechanical Phenomena; D008970:Molecular Weight; D010671:Phenylurea Compounds / Q000737:chemistry* / Q000494:pharmacology*; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D012997:Solvents / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D020100:Hydrogels; D007191:Indazoles; D010671:Phenylurea Compounds; D047428:Protein Kinase Inhibitors; D012997:Solvents; D014508:Urea; C513486:linifanib; D020794:Receptor Protein-Tyrosine Kinases