title: Growth and Tolerance of Term Infants Fed Formula With Probiotic Lactobacillus reuteri.
abstract: BACKGROUND
  Lactobacillus reuteri has been studied for its safety and beneficial effects in infants. This study assessed growth of infants fed a partially hydrolyzed whey formula with L reuteri.
  
  
  METHODS
  Healthy term infants were randomized to 1 of 2 formulas (partially hydrolyzed whey formula with (PRO) or without (CON) L reuteri from 14 to 112 days of age. Anthropometric measures were assessed at 14, 28, 56, 84, and 112 days of age. Tolerance records were completed 2 days prior to each visit.
  
  
  RESULTS
  A total of 122 subjects completed study per protocol (60 PRO, 62 CON). No differences were seen in daily weight gain, length, or head circumference. Overall, between groups, there were no significant differences in formula intake, stool frequency, color, consistency, flatulence, frequency of spit-up/vomiting, mood, sleep, or incidence of adverse events.
  
  
  CONCLUSIONS
  Infants fed probiotic formula had similar growth to infants fed control formula. Both formulas were well tolerated.
authors.affiliation: Nestlé Nutrition, Florham Park, NJ, USA.
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Cekola
authors.affiliation: Nestlé Nutrition, Florham Park, NJ, USA.
authors.forename: Laura A
authors.initials: LA
authors.lastname: Czerkies
authors.affiliation: Nestlé Nutrition, Florham Park, NJ, USA.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Storm
authors.affiliation: Statistical Consulting, LLC, Portage, MI, USA.
authors.forename: Mei H
authors.initials: MH
authors.lastname: Wang
authors.affiliation: Medical University of South Carolina, Charleston, SC, USA.
authors.forename: James
authors.initials: J
authors.lastname: Roberts
authors.affiliation: Nestlé Nutrition, Vevey, Switzerland jose.saavedra@nestle.com.
authors.forename: José M
authors.initials: JM
authors.lastname: Saavedra
mesh_terms: D000886:Anthropometry; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn / Q000254:growth & development; D052200:Limosilactobacillus reuteri; D019936:Probiotics / Q000494:pharmacology*; D015430:Weight Gain; D000067796:Whey
keywords: Lactobacillus reuteri; infant formula; infant growth; lactose; probiotic