title: [Prevalence of gastrointestinal disorders in adults with common variable immunodeficiency at Specialty Hospital Dr. Bernardo Sepulveda].
abstract: BACKGROUND
  The common variable immunodeficiency (CVID) shows a variable incidence, from 1:15,000 to 1:117,000, without gender predominance. The incidence of gastrointestinal manifestations in these patients ranges from 20-60%, and these may be the first and only clinical manifestation of CVID, while other patients develop gastrointestinal complications during the course of it. In Mexico there is little information regarding the type and frequency of gastrointestinal disorders presented by adult patients with CVID.
  
  
  OBJECTIVE
  To determine the prevalence of gastrointestinal manifestations in adult patients with CVID.
  
  
  METHODS
  A descriptive, cross-sectional and observational study was made including patients with CVID attending Primary Immunodeficiency Clinic of Allergy and Clinical Immunology Department, Specialties Hospital, National Medical Center SXXI, Mexico City. All patients underwent gastrointestinal symptoms questionnaire, laboratory, cabinet, endoscopy and breath test for bacterial overgrowth.
  
  
  RESULTS
  We evaluated 17 patients, 8 men and 9 women with an average age of 36 years with a definitive diagnosis of CVID according to international criteria; 59% had abdominal pain, 53% abdominal distension; only 3 patients (17.6%) reported constipation; 47% had chronic diarrhea, of which only 2 (11.8%) had rectal pushing. The diagnoses of gastrointestinal manifestations of this population were: 18% chronic diarrhea, celiac disease and bacterial overgrowth, 24% gastrointestinal functional disorder, 12% constipation and 6% dyspepsia. One patient (6%) had no gastrointestinal symptoms.
  
  
  CONCLUSIONS
  Prevalence of gastrointestinal diseases in adult patients with common variable immunodeficiency was 94%. There was no gender predominance. It is therefore important that patients with CVID will conduct a study protocol that includes a complete medical history considering gastrointestinal symptoms and signs, in order to determine timely diagnosis and therapeutic approach.
authors.affiliation: Departamento de Gastroenterología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. aeri_05@hotmail.com.
authors.forename: Elda Victoria
authors.initials: EV
authors.lastname: Rodríguez-Negrete
authors.forename: Arturo
authors.initials: A
authors.lastname: Mayoral-Zavala
authors.forename: Karen Alicia
authors.initials: KA
authors.lastname: Rodríguez-Mireles
authors.forename: Oscar Edmundo
authors.initials: OE
authors.lastname: Díaz de León-Salazar
authors.forename: Oscar
authors.initials: O
authors.lastname: Hernández-Mondragón
authors.forename: Luz María
authors.initials: LM
authors.lastname: Gómez-Jiménez
authors.forename: R
authors.initials: R
authors.lastname: Moreno-Alcántar
authors.forename: Baldomero
authors.initials: B
authors.lastname: González-Virla
keywords: Common variable immunodeficiency; Gastrointestinal disorders