title: Cytological scoring and prognosis of poorly differentiated endometrioid adenocarcinoma.
abstract: OBJECTIVE
  Histopathological variation has been demonstrated in grade 3 endometrioid adenocarcinomas. We attempted to evaluate the clinicopathological features of grade 3 tumors by endometrial cytological features using a scoring system.
  
  
  METHODS
  Twenty-one endometrial cytological samples were evaluated using 5 cytological features: rates of cluster formation in tumor cells; nuclear pleomorphism; nuclear dimension; size of nucleoli, and chromatin structure and distribution. The relationships between cytological scores and clinicopathological factors or prognosis were investigated.
  
  
  RESULTS
  The median cytological score was 6 (range 4-14); therefore, samples with scores of 4-5 were defined as having low scores, while those with scores of 6-14 were defined as high scores. The accuracy of the cytological diagnosis for grade 3 tumors in the high score group (8/10 patients, 80.0%) was significantly higher than that of the low score group (2/11 patients, 18.2%; p=0.009). Significant relationships between cytological scores and lymph node metastases or positive peritoneal cytology were observed (p=0.03 and 0.035, respectively). The overall survival rate was significantly worse in the high score group (30.0%) than the low score group (88.9%; p=0.02).
  
  
  CONCLUSIONS
  Grade 3 endometrioid adenocarcinomas varied in cytological features; according to the scoring system used, high scores were associated with worse clinicopathological factors and poorer prognosis than low scores.
authors.forename: Rina
authors.initials: R
authors.lastname: Kato
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Torii
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Udagawa
authors.forename: Ichio
authors.initials: I
authors.lastname: Fukasawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D002454:Cell Differentiation; D002467:Cell Nucleus / Q000473:pathology; D002843:Chromatin / Q000473:pathology; D016889:Endometrial Neoplasms / Q000473:pathology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D002843:Chromatin