title: Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells.
abstract: Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.
authors.affiliation: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea.
authors.forename: Minhwa
authors.identifier: 0000-0001-5732-6915
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea.
authors.forename: Yu-Hee
authors.identifier: 0000-0002-7804-9264
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea.
authors.forename: Jung-Hwa
authors.identifier: 0000-0003-1887-7823
authors.initials: JH
authors.lastname: Ryu
authors.affiliation: Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea.
authors.forename: So-Youn
authors.identifier: 0000-0001-6902-0315
authors.initials: SY
authors.lastname: Woo
authors.affiliation: Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea.
authors.forename: Kyung-Ha
authors.initials: KH
authors.lastname: Ryu