title: Influence of leptomeningeal collateral pattern on the prognostic value of mismatch in acute anterior circulation stroke.
abstract: OBJECTIVE
  This study aimed to investigate whether and to what degree leptomeningeal collateral flow as detected on angiography influences the prognostic value of computed tomography perfusion-estimated mismatch in interventional treatment of acute anterior circulation stroke.
  
  
  METHODS
  Thirty-eight consecutive patients with acute anterior circulation stroke who received interventional neuroradiologic treatment were assigned one of 2 groups depending on the patient's degree of collateral flow (18 patients with poor collaterals, 20 patients with high degree collaterals) according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology grading system. In a multiregression model, we investigated a possible interaction between 2 independent variables mismatch ratio and degree of collateral flow using a "centered" variable approach.
  
  
  RESULTS
  The mismatch ratio per se showed a significant correlation with final clinical outcome (β coefficient, -0.79; P = 0.02); whereas, there was no interaction shown between mismatch degree of collateral flow (β coefficient, 0.54; P = 0.1).
  
  
  CONCLUSIONS
  This study suggests that the predictive value of computed tomography perfusion-estimated mismatch is not influenced by the degree of leptomeningeal collateral flow.
authors.affiliation: From the Institute of Neuroradiology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Alexander
authors.initials: A
authors.lastname: Spiessberger
authors.forename: Christian
authors.initials: C
authors.lastname: Federau
authors.forename: Roman
authors.initials: R
authors.lastname: Guggenberger
authors.forename: Spyros
authors.initials: S
authors.lastname: Kollias
mesh_terms: D000368:Aged; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D008578:Meninges / Q000098:blood supply*; D011379:Prognosis; D012189:Retrospective Studies; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D017131:Thrombectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome