title: Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.
abstract: BACKGROUND
  Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM.
  
  
  OBJECTIVE
  This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL.
  
  
  METHODS
  A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed.
  
  
  RESULTS
  The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions.
  
  
  CONCLUSIONS
  The application of ADSC-CM is a potential treatment option for FPHL.
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, South Korea.
authors.forename: Hyoseung
authors.initials: H
authors.lastname: Shin
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Hyeong Ho
authors.initials: HH
authors.lastname: Ryu
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Ohsang
authors.initials: O
authors.lastname: Kwon
authors.affiliation: Cellpark Clinic, Seoul, South Korea.
authors.forename: Byung-Soon
authors.initials: BS
authors.lastname: Park
authors.affiliation: Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, South Korea.
authors.forename: Seong Jin
authors.initials: SJ
authors.lastname: Jo
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D000368:Aged; D000505:Alopecia / Q000601:surgery*; D017077:Culture Media, Conditioned; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D055815:Young Adult
chemical_list: D017077:Culture Media, Conditioned