title: Infantile colic associated with childhood migraine: A prospective cohort study.
abstract: OBJECTIVE
  To explore the association between infantile colic and adolescent migraine.
  
  
  METHODS
  In a randomized general population sample, families expecting their first child were prospectively followed for infantile colic and adolescent migraine.
  
  
  RESULTS
  Colic was diagnosed in 160 (13%) of 1267 infants until the age of 3 months. Migraine was ascertained in 129 (16%) of 787 adolescents at age 18 years. History of infantile colic was identified in 96 (12%) of 787 adolescents and no such history in 658 (88%) of 787 adolescents. Migraine was present in 22 (23%)/96 adolescents who had a history of infantile colic, but in only 74 (11%)/658 ones who had no such history. Of the 22 adolescents, 14 (64%) had migraine without aura and eight (36%) had migraine with aura. Infants with colic had an almost three-fold risk (risk ratio 2.8, 95% confidence interval 1.2-6.5) for adolescent migraine without aura, but no increased risk for migraine with aura (0.8, 0.3-2.2).
  
  
  CONCLUSIONS
  Infantile colic seems to be associated with an increased risk for migraine without aura, but not for migraine with aura. Whether infantile colic per se is a type of infantile migraine or an antecedent of future migraine remains to be answered by further research.
authors.affiliation: Department of Public Health, University of Turku, Finland Department of Child Neurology, University of Turku, Finland matti.sillanpaa@utu.fi.
authors.forename: Matti
authors.initials: M
authors.lastname: Sillanpää
authors.affiliation: Department of Public Health, University of Turku, Finland Department of Child Neurology, University of Turku, Finland.
authors.forename: Maiju
authors.initials: M
authors.lastname: Saarinen
mesh_terms: D000293:Adolescent; D015331:Cohort Studies; D003085:Colic / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology; D020325:Migraine with Aura / Q000175:diagnosis* / Q000453:epidemiology*; D020326:Migraine without Aura / Q000175:diagnosis* / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
keywords: Adolescent; headache; infantile colic; migraine