title: Seasonal distribution of pharmaceuticals in marine water and sediment from a Mediterranean coastal lagoon (SE Spain).
abstract: The seasonal variations in the occurrence and distribution of pharmaceuticals were evaluated in seawater and sediment of Mar Menor lagoon from spring 2010 to winter 2011. A total of 20 pharmaceuticals in seawater and 14 in sediments were found at concentrations from low ngL(-)(1) up to 168ngL(-)(1) (azithromycin) in seawater and from low ngg(-1) up to 50.3ngg(-1) (xylazine) in sediments. Azithromycin, xylazine and metoprolol were the most ubiquitous compounds in seawater since they were found in all seawater samples collected. Seven compounds were quantified in both matrices: clarithromycin, erythromycin, hydrochlorothiazide, irbesartan, losartan, salicylic acid and valsartan. Seasonal distribution profiles revealed different sources of pollutants associated to both, El Albujón watercourse (which receives the input of a WWTP) and other non-controlled discharges, into the lagoon. In summer the highest concentrations in seawater for most of the pharmaceuticals were detected close to main touristic nuclei, probably as consequence of sources such as the excretion from bathers and/or other non-controlled discharges, these being significantly higher than in autumn and winter for antibiotics. On the contrary, the mean concentration of lorazepam was significantly higher in colder seasons than in warmer ones. Sulfamethoxazole, erythromycin and especially clarithromycin showed hazard quotients higher than 1 in seawater at some areas of this lagoon indicating a potential risk to aquatic organisms in such specific areas.
authors.affiliation: Instituto Español de Oceanografía, Centro Oceanográfico de Murcia, Apdo. 22, C/ Varadero 1, 30740 San Pedro del Pinatar, Murcia, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Moreno-González
authors.affiliation: Catalan Institute for Water Research (ICRA)-Parc Científic i Tecnològic de la Universitat de Girona, Edifici H(2)O, Emili Grahit,101, 17003 Girona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Rodriguez-Mozaz
authors.affiliation: Catalan Institute for Water Research (ICRA)-Parc Científic i Tecnològic de la Universitat de Girona, Edifici H(2)O, Emili Grahit,101, 17003 Girona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gros
authors.affiliation: Catalan Institute for Water Research (ICRA)-Parc Científic i Tecnològic de la Universitat de Girona, Edifici H(2)O, Emili Grahit,101, 17003 Girona, Spain.; Department of Environmental Chemistry, IDAEA-CSIC, C/Jordi Girona 18-26, 08034 Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Barceló
authors.affiliation: Instituto Español de Oceanografía, Centro Oceanográfico de Murcia, Apdo. 22, C/ Varadero 1, 30740 San Pedro del Pinatar, Murcia, Spain.. Electronic address: victor.leon@mu.ieo.es.
authors.forename: V M
authors.initials: VM
authors.lastname: León
mesh_terms: D004784:Environmental Monitoring; D019015:Geologic Sediments / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012621:Seasons; D012623:Seawater / Q000737:chemistry*; D013030:Spain; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations; D014874:Water Pollutants, Chemical
keywords: Coastal lagoon; Distribution; Environmental risk; Pharmaceuticals; Seasonality; Seawater; Sediment