title: Structure and Dynamics of the Native HIV-1 Env Trimer.
abstract: HIV-1/AIDS remains one of the worst pandemics in human history. Despite tremendous efforts, no effective vaccine has been found. Recent reports give new insights into the structure and dynamics of the HIV-1 Env trimer and renew hopes that a better understanding of Env will translate into new vaccine candidates and more-effective antiretroviral therapies.
authors.affiliation: Department of Molecular Biology & Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA James.Munro@tufts.edu walther.mothes@yale.edu.
authors.forename: James B
authors.initials: JB
authors.lastname: Munro
authors.affiliation: Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA James.Munro@tufts.edu walther.mothes@yale.edu.
authors.forename: Walther
authors.initials: W
authors.lastname: Mothes
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology / Q000302:isolation & purification; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D015700:HIV Envelope Protein gp41 / Q000737:chemistry* / Q000276:immunology / Q000378:metabolism; D015497:HIV-1 / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D055503:Protein Multimerization
chemical_list: D016915:AIDS Vaccines; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; C514793:gp120 protein, Human immunodeficiency virus 1; C514787:gp41 protein, Human immunodeficiency virus 1