title: [Personalized treatment of tumor-bearings after prediction of radio and chemoradio-therapy efficacy by means of blood DNA radiosensitivity].
abstract: Ongoing studies on the tumor and non-tumor samples carried out worldwide give evidence that some apoptotic indexes, DNA-based microarray molecular profiling analysis as well as determination of single nucleotide polymorphisms in the genome of a patient's tumor can serve perspective markers of radiosensitivity for the response prediction in individual patients to intendedradiation therapy. Over the last years there has been an increasing interest in radiogenomic and characterization of DNA array molecular profiles that can predict the response to irradiation in tumor and non-tumor tissues. Now a technology of the short-term and inexpensive determination of indices aimed at an objectively based use of radiation therapy in experiment or clinic after evaluation of blood DNA radiosensitivity has been developed.
authors.forename: S D
authors.initials: SD
authors.lastname: Ivanov
authors.forename: L I
authors.initials: LI
authors.lastname: Korytova
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D014408:Biomarkers, Tumor; D059248:Chemoradiotherapy; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D057285:Precision Medicine; D011836:Radiation Tolerance / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004247:DNA