title: Electrolyte changes after bowel preparation for colonoscopy: A randomized controlled multicenter trial.
abstract: OBJECTIVE
  To investigate the electrolyte changes between 2-L polyethylene glycol with ascorbic acid 20 g (PEG-Asc) and 4-L PEG solutions.
  
  
  METHODS
  From August 2012 to February 2013, a total of 226 patients were enrolled at four tertiary hospitals. All patients were randomly allocated to a PEG-Asc group or a 4-L PEG. Before colonoscopy, patients completed a questionnaire to assess bowel preparation-related symptoms, satisfaction, and willingness. Endoscopists assessed the bowel preparation using the Boston Bowel Preparation Scale (BBPS). In addition, blood tests, including serum electrolytes, serum osmolarity, and urine osmolarity were evaluated both before and after the procedure.
  
  
  RESULTS
  A total of 226 patients were analyzed. BBPS scores were similar and the adequate bowel preparation rate (BBPS ≥ 6) was not different between the two groups (PEG-Asc vs 4-L PEG, 73.2% vs 76.3%, P = 0.760). Bowel preparation-related symptoms also were not different between the two groups. The taste of PEG-Asc was better (41.1% vs 16.7%, P < 0.001), and the willingness to undergo repeated bowel preparation was higher in the PEG-Asc group (73.2% vs 59.3%, P = 0.027) than in 4-L PEG. There were no significant changes in serum electrolytes in either group.
  
  
  CONCLUSIONS
  In this multicenter trial, bowel preparation with PEG-Asc was better than 4-L PEG in terms of patient satisfaction, with similar degrees of bowel preparation and electrolyte changes.
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Kyong Joo
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Hong Jun
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Hyun-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Baik
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Yeon Soo
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Sung Chul
authors.initials: SC
authors.lastname: Park
authors.affiliation: Kyong Joo Lee, Hong Jun Park, Hyun-Soo Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 220-701, South Korea.
authors.forename: Hyun Il
authors.initials: HI
authors.lastname: Seo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003113:Colonoscopy; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011237:Predictive Value of Tests; D056910:Republic of Korea; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D062606:Tertiary Care Centers; D007507:Therapeutic Irrigation / Q000009:adverse effects / Q000379:methods*
chemical_list: D015415:Biomarkers; D002400:Cathartics; D004573:Electrolytes; D011092:Polyethylene Glycols; D001205:Ascorbic Acid
keywords: Ascorbic acid; Bowel preparation; Colonoscopy; Electrolyte; Polyethylene glycol