title: Application of a method used to deconstruct a single dose pharmacokinetic profile from multiple dose data.
abstract: With traditional non-compartmental methods, it is challenging to deconstruct plasma concentration versus time curves to assess the influence of individual doses. This study describes the application of a mathematical approach used to deconstruct a single dose curve using data derived from the second, third, fourth or nth dosing interval. Using data from a prospective clinical trial it is demonstrated that this approach reliably estimates pharmacokinetic parameters measured following two doses of zolpidem tartrate. Additionally, the study demonstrates the application of this approach using previously published data from a single- and multiple-dose pharmacokinetic study of the antibiotic gatifloxacin. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.|Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Stockmann
authors.affiliation: Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.|Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Spigarelli
authors.affiliation: James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.|Shriners Hospitals for Children, Cincinnati, Ohio, USA.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Healy
authors.affiliation: Shriners Hospitals for Children, Cincinnati, Ohio, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Gottschlich
authors.affiliation: Shriners Hospitals for Children, Cincinnati, Ohio, USA.|Department of Surgery, University of Cincinnati, Cincinnati, Ohio, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kagan
authors.affiliation: Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.|Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
authors.forename: Alfred H
authors.initials: AH
authors.lastname: Balch
authors.affiliation: Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.|Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sherwin
keywords: curve stripping; exponential; parameter estimation; pharmacokinetics