title: Correlation of manganese with thyroid function in females having hypo- and hyperthyroid disorders.
abstract: The aim of present study was to compare the level of manganese (Mn) with thyroid functions, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxin (FT4) of females having hyper- (HPRT) and hypothyroid (HPOT) disorder. For comparative study, females of the same age group (16-30 years) having no thyroid disorders were selected as referents. The serum samples were acid digested prior to analysis by electrothermal atomic absorption spectrometry. The validity and accuracy of the methodology was checked by a certified sample. The resulted data indicated that the mean values of Mn in serum samples of females have hyperthyroidism was significantly higher than referent subjects (p < 0.01), while lower values of Mn was observed in serum samples of hypothyroid patients. The mean values of FT3 and FT4 were found to be lower while TSH higher is in HPRT patients than age-matched healthy control females (p = <0.01). The reverse resulted data of these thyroid hormones was observed in HPOT patients (0.003).
authors.affiliation: National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan, nusrat.memon138@gmail.com.
authors.forename: Nusrat Shahab
authors.initials: NS
authors.lastname: Memon
authors.forename: Tasneem Gul
authors.initials: TG
authors.lastname: Kazi
authors.forename: Hassan Imran
authors.initials: HI
authors.lastname: Afridi
authors.forename: Jameel Ahmed
authors.initials: JA
authors.lastname: Baig
authors.forename: Oan Muhammad
authors.initials: OM
authors.lastname: Sahito
authors.forename: Shahnawaz
authors.initials: S
authors.lastname: Baloch
authors.forename: Muhammad
authors.initials: M
authors.lastname: Waris
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D008345:Manganese / Q000097:blood*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D013963:Thyroid Hormones; D008345:Manganese