title: Fluorescent sensing of monofunctional platinum species.
abstract: We report here FDCPt1, a novel selective fluorescent sensor for monofunctional platinum species. In the presence of such species, FDCPt1 exhibits a 70-fold increase in fluorescence emission, and can be used to monitor the metabolism of Pt(II)-based complexes in colorectal cancer cells. This probe is therefore expected to be valuable in studying changes in Pt coordination and distribution during chemotherapy.
authors.affiliation: School of Chemistry, The University of Sydney, Building F11, NSW 2006, Australia. elizabeth.new@sydney.edu.au.
authors.forename: Clara
authors.initials: C
authors.lastname: Shen
authors.forename: Benjamin D W
authors.initials: BD
authors.lastname: Harris
authors.forename: Lucy J
authors.initials: LJ
authors.lastname: Dawson
authors.forename: Kellie A
authors.initials: KA
authors.lastname: Charles
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Hambley
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: New
mesh_terms: D018938:Caco-2 Cells; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D019793:Fluorescein / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D009944:Organoplatinum Compounds / Q000032:analysis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009944:Organoplatinum Compounds; D019793:Fluorescein