title: The new deal: a potential role for secreted vesicles in innate immunity and tumor progression.
abstract: Tumors must evade the immune system to survive and metastasize, although the mechanisms that lead to tumor immunoediting and their evasion of immune surveillance are far from clear. The first line of defense against metastatic invasion is the innate immune system that provides immediate defense through humoral immunity and cell-mediated components, mast cells, neutrophils, macrophages, and other myeloid-derived cells that protect the organism against foreign invaders. Therefore, tumors must employ different strategies to evade such immune responses or to modulate their environment, and they must do so prior metastasizing. Exosomes and other secreted vesicles can be used for cell-cell communication during tumor progression by promoting the horizontal transfer of information. In this review, we will analyze the role of such extracellular vesicles during tumor progression, summarizing the role of secreted vesicles in the crosstalk between the tumor and the innate immune system.
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Department of Pediatrics, Weill Cornell Medical College , New York, NY , USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Benito-Martin
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Department of Pediatrics, Weill Cornell Medical College , New York, NY , USA.
authors.forename: Angela
authors.initials: A
authors.lastname: Di Giannatale
authors.affiliation: Department of Oncology and Pathology, Karolinska Institutet , Stockholm , Sweden.
authors.forename: Sophia
authors.initials: S
authors.lastname: Ceder
authors.affiliation: Children's Cancer and Blood Foundation Laboratories, Department of Pediatrics, Weill Cornell Medical College , New York, NY , USA ; Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Centre (CNIO) , Madrid , Spain.
authors.forename: Héctor
authors.initials: H
authors.lastname: Peinado
keywords: exosomes; innate immunity; tumor progression; tumor surveillance