title: Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus.
abstract: In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.
authors.affiliation: Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Yaqiang
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Chengjun
authors.initials: C
authors.lastname: Song
authors.affiliation: Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Zhejun
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Human Anatomy, Chengde Medical College, Chengde 067000, Hebei Province, China.
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Xue
keywords: Akt signal transduction pathway; apoptosis; hippocampus; neural regeneration; sericin; type 2 diabetes mellitus