title: The evolving classification of renal cell neoplasia.
abstract: The classification of renal cell neoplasia is morphologically based; however, this has evolved over the last 35 years with the incorporation of genetic characteristics into the diagnostic features of some tumors. The 2013 Vancouver classification recognized 17 morphotypes of renal parenchymal malignancy and two benign tumors. This classification included the newly established entities tubulocystic renal cell carcinoma (RCC)), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, microphthalmia transcription factor family translocation RCC and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition to these newly described forms of RCC there are a number of novel tumors that are currently recognized as emerging entities. These are likely to be incorporated into subsequent classifications and include thyroid-like follicular RCC, succinate dehydrogenase B mutation-associated RCC, ALK translocation RCC, tuberous sclerosis complex-associated RCC, and RCC with (angio) leiomyomatous stroma.
authors.affiliation: Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago Wellington, PO Box 7343, Wellington, New Zealand. Electronic address: bd@wnmeds.ac.nz.
authors.forename: Brett
authors.initials: B
authors.lastname: Delahunt
authors.affiliation: Department of Pathology and Molecular Medicine, McMaster University, Toronto, Canada.
authors.forename: John R
authors.initials: JR
authors.lastname: Srigley
mesh_terms: D002292:Carcinoma, Renal Cell / Q000145:classification* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000145:classification* / Q000235:genetics / Q000473:pathology*
keywords: Renal cell carcinoma; Rochester/Heidelberg; Vancouver; classification; morphology; renal adenoma