title: Vitamin D receptor FokI, BsmI, TaqI, ApaI, and EcoRV polymorphisms and susceptibility to melanoma: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to examine whether vitamin D receptor (lVDR) polymorphisms are associated with susceptibility to melanoma.
  
  
  METHODS
  A meta-analysis was carried out to investigate the association between the VDR FokI, BsmI, TaqI, ApaI, and EcoRV polymorphisms and susceptibility to melanoma.
  
  
  RESULTS
  A total of 11 studies were evaluated, which included 4,413 patients and 4,072 controls (all European). The meta-analysis revealed no association between melanoma and the BsmI B allele (odds ratio/OR=0.901, 95% confidence interval/CI=0.783-1.036, p=0.144). However, an association was shown between melanoma and the Bb+bb genotype (OR=0.868, 95% CI=0.767-0.982, p=0.025). No association was noticed between melanoma and FokI polymorphism (OR for the F allele=1.016, 95% CI=0.869-1.189, p=0.839). Moreover, melanoma risk was not associated with the TaqI, ApaI, and EcoRV polymorphisms (OR for the T allele=0.986, 95% CI=0.842-1.156, p=0.864; OR for the A allele=0.949, 95% CI=0.842-1.069, p=0.388; OR for the E allele=0.993, 95% CI=0.875-1.126, p=0.911, respectively).
  
  
  CONCLUSIONS
  This meta-analysis demonstrated that the VDR BsmI polymorphism is associated with susceptibility to melanoma in Europeans, suggesting that carrying the VDR BsmI B allele may be a protective factor against melanoma development.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Korea University Medical Center, Seoul, Korea.
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Gwan
authors.initials: G
authors.lastname: Gyu Song
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008545:Melanoma / Q000208:ethnology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D065840:Protective Factors; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D044465:White People / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D018167:Receptors, Calcitriol; C579457:VDR protein, human