title: The efficacy of minocycline in inflammatory dermatoses: a case of prurigo pigmentosa of prepubescent onset in Western world.
abstract: We present a 21-year-old Italian girl with an 8-year history of missed diagnosed prurigo pigmentosa (PP) successfully treated with short monotherapy with minocycline. PP is an inflammatory disease characterized by recurrent pruritic erythematous papules followed by reticular hyperpigmentation usually located on the trunk. About 300 cases of PP have been described mainly in Japan, whereas only few cases have been reported in Italy. This report shows that minocycline is rapidly effective probably through its ability to scavenge reactive oxygen species and to inhibit the chemotaxis and neutrophil function. Other than its ethnic rarity, this case is very interesting because it is the third case of PP in Caucasian patient with prepubescent onset.
authors.affiliation: Dermatology Clinic, Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Amedeo Avogadro, Novara, Italy.
authors.forename: Laura Cristina
authors.initials: LC
authors.lastname: Gironi
authors.affiliation: Dermatology Clinic, Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Amedeo Avogadro, Novara, Italy.
authors.forename: Pamela
authors.initials: P
authors.lastname: Farinelli
authors.affiliation: Pathology Unit, Department of Health Sciences, University of Piemonte Orientale, Amedeo Avogadro, Novara, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Giacalone
authors.affiliation: Dermatology Clinic, Department of Clinical and Experimental Medicine, University of Piemonte Orientale, Amedeo Avogadro, Novara, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Colombo
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000175:diagnosis / Q000188:drug therapy*; D007558:Italy; D008911:Minocycline / Q000627:therapeutic use*; D011536:Prurigo / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline
keywords: inflammatory disorders; minocycline; prurigo pigmentosa; reticulate hyperpigmentation