title: Implication of corticotropic hormone axis in eating behaviour pattern in obese and type 2 diabetic participants.
abstract: In Algeria, eating behaviour has been increasingly deviated from its traditional Mediterranean diet to modern fast food style. The present study examines the interactions between eating behaviour pattern (EBP), corticotropic hormone axis and the metabolic syndrome. Our Algerian population cohort comprised of 410 participants (130 obese, 170 type 2 diabetics and 110 healthy participants). The EBP was evaluated by the Three-Factor Eating Questionnaire test. The anthropometric and metabolic parameters (glucose, TAG, HDL, LDL and cholesterol) and the concentrations of hormones (insulin, adrenocorticotropin hormone (ACTH), cortisol and growth hormone) were determined by biometrics, spectrophotometry and RIA, respectively. Multivariate analyses showed a high correlation between the EBP and the metabolic syndrome, particularly between insulin-resistant state and hypertrophy of visceral adipose tissue. Compared with healthy participants, obese ones showed the hyperphagic type of EBP, i.e. disinhibition and hunger disorders. Conversely, the diabetics showed both the hypophagic and hyperphagic type of EBP. In diabetic and obese participants, cortisol and ACTH secretions were significantly altered, leading to metabolic disorders. The present study confirms the role of EBP in obesity and diabetes.
authors.affiliation: Laboratoire de Bioénergétique et Métabolisme Intermédiaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene,Alger,Algérie.
authors.forename: Hassiba
authors.initials: H
authors.lastname: Benbaibeche
authors.affiliation: Service de Médecine Nucléaire, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie.
authors.forename: El Mahdi
authors.initials: el M
authors.lastname: Haffaf
authors.affiliation: Laboratoire de Biochimie, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie.
authors.forename: Ghouti
authors.initials: G
authors.lastname: Kacimi
authors.affiliation: Service de Diabétologie, CHU-Hôpital Mohamed Seghir Nekache,Alger,Algérie.
authors.forename: Brahim
authors.initials: B
authors.lastname: Oudjit
authors.affiliation: Physiologie de la Nutrition & Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup,6 Boulevard Gabriel,Dijon21000,France.
authors.forename: Naim Akhtar
authors.initials: NA
authors.lastname: Khan
authors.affiliation: Laboratoire de Bioénergétique et Métabolisme Intermédiaire, Faculté des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene,Alger,Algérie.
authors.forename: Elhadj Ahmed
authors.initials: EA
authors.lastname: Koceïr
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000462:Algeria; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004032:Diet; D038441:Diet, Mediterranean; D005247:Feeding Behavior; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D011863:Radioimmunoassay; D011795:Surveys and Questionnaires
chemical_list: D000324:Adrenocorticotropic Hormone; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D013006:Growth Hormone; D006854:Hydrocortisone; D007328:Insulin; C517652:hemoglobin A1c protein, human
keywords: Obesity