title: Copolymer Networks From Oligo(ε-caprolactone) and n-Butyl Acrylate Enable a Reversible Bidirectional Shape-Memory Effect at Human Body Temperature.
abstract: Exploiting the tremendous potential of the recently discovered reversible bidirectional shape-memory effect (rbSME) for biomedical applications requires switching temperatures in the physiological range. The recent strategy is based on the reduction of the melting temperature range (ΔT m ) of the actuating oligo(ε-caprolactone) (OCL) domains in copolymer networks from OCL and n-butyl acrylate (BA), where the reversible effect can be adjusted to the human body temperature. In addition, it is investigated whether an rbSME in the temperature range close or even above Tm,offset (end of the melting transition) can be obtained. Two series of networks having mixtures of OCLs reveal broad ΔTm s from 2 °C to 50 °C and from -10 °C to 37 °C, respectively. In cyclic, thermomechanical experiments the rbSME can be tailored to display pronounced actuation in a temperature interval between 20 °C and 37 °C. In this way, the application spectrum of the rbSME can be extended to biomedical applications.
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany.|Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476, Potsdam, Germany.|Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Kantstraße 55, 14513, Teltow, Germany.
authors.forename: Mersa
authors.initials: M
authors.lastname: Saatchi
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany.|Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Kantstraße 55, 14513, Teltow, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Behl
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Nöchel
authors.affiliation: Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany.|Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476, Potsdam, Germany.|Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Kantstraße 55, 14513, Teltow, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001831:Body Temperature; D002208:Caproates / Q000737:chemistry*; D018594:Human Body; D006801:Humans; D007783:Lactones / Q000737:chemistry*; D008422:Materials Testing; D044367:Phase Transition; D018583:Pliability
chemical_list: D000179:Acrylates; D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; C121056:caprolactone; C032490:n-butyl acrylate
keywords: body temperature; broad melting temperature range; copolymer networks; orientational memory; reversible bidirectional shape-memory polymer