title: Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme.
abstract: PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20 protein families sharing a common α,β-barrel domain. Of these, six different groups bind heme inside the barrel's interior, using it alternately as a cofactor, substrate, or product. Focusing on these six, an integrated picture of structure, sequence, taxonomy, and mechanism is presented here, detailing how a single structural motif might be able to mediate such an array of functions with one of nature's most important small molecules.
authors.affiliation: Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States.
authors.forename: Arianna I
authors.initials: AI
authors.lastname: Celis
authors.affiliation: Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, United States. Electronic address: jdubois@chemistry.montana.edu.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: DuBois
mesh_terms: D001665:Binding Sites; D006418:Heme / Q000378:metabolism*; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D011506:Proteins; D006418:Heme
keywords: Aldoxime dehydratase; Chlorite dismutase; EfeB; Heme; Heme biosynthesis; Heme oxygenase; IsdG