title: Triple combination treatment with fractional CO2 laser plus topical betamethasone solution and narrowband ultraviolet B for refractory vitiligo: a prospective, randomized half-body, comparative study.
abstract: Vitiligo on extremities and/or bony prominences is very resistant to treatment. Twenty-five patients with symmetrical and stable vitiligo on extremities and/or bony prominences were enrolled. The treatment side received fractional carbon dioxide laser followed by topical compound betamethasone solution and narrowband ultraviolet B phototherapy. The control side received laser treatment plus phototherapy. The result of treatment side showed that 44% patients achieved over 50% re-pigmentation and patient satisfaction score was 5.12 ± 3.23, higher than those of control (p < 0.05). Adverse events were slight and tolerable. The triple combination treatment could be used as an alternative modality for refractory vitiligo.
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Gao
authors.affiliation: Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Hong-Duo
authors.initials: HD
authors.lastname: Chen
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001623:Betamethasone / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D019999:Pharmaceutical Solutions; D011446:Prospective Studies; D012880:Skin Pigmentation / Q000187:drug effects* / Q000528:radiation effects*; D013997:Time Factors; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000009:adverse effects; D014820:Vitiligo / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D019999:Pharmaceutical Solutions; D001623:Betamethasone
keywords: laser; therapy-topical; vitiligo