title: Physical mechanisms behind the large scale features of chromatin organization.
abstract: We review the picture emerging from recently published models of classical polymer physics of the general features of chromatin large scale spatial organization, as revealed by microscopy and Hi-C data.
authors.affiliation: a Berlin Institute for Medical Systems Biology; Max Delbrück Center for Molecular Medicine; Berlin-Buch, Germany.
authors.forename: Ana
authors.initials: A
authors.lastname: Pombo
authors.forename: Mario
authors.initials: M
authors.lastname: Nicodemi
mesh_terms: D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008958:Models, Molecular
chemical_list: D002843:Chromatin
keywords: computer simulations; contact matrices; genome organization; long-range chromatin interactions; polymer physics