title: Effect of intravariceal sclerotherapy combined with esophageal mucosal sclerotherapy using small-volume sclerosant for cirrhotic patients with high variceal pressure.
abstract: OBJECTIVE
  To explore the effect of intravariceal-mucosal sclerotherapy using small dose of sclerosant on the recurrence of esophageal varices.
  
  
  METHODS
  We randomly assigned 38 cirrhotic patients with previous variceal bleeding and high variceal pressure (> 15.2 mmHg) to receive endoscopic variceal ligation (EVL) and combined intravariceal and esophageal mucosal sclerotherapy (combined group) using small-volume sclerosant. The end-points of the study were rebleeding and recurrence of esophageal varices.
  
  
  RESULTS
  During a median follow-up period of 16 mo, varices recurred in 1 patient in the combined group as compared with 7 patients in the EVL group (P = 0.045). Rebleeding occurred in 3 patients in the EVL group as compared with 1 patient in the combined group (P = 0.687). No patient died in the two groups. No significant differences were observed between the two groups with respect to serious adverse events.
  
  
  CONCLUSIONS
  Intravariceal-mucosal sclerotherapy using small dose of sclerosant is more effective than EVL in decreasing the incidence of variceal recurrence for cirrhotic patients.
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: De-Run
authors.initials: DR
authors.lastname: Kong
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Jin-Guang
authors.initials: JG
authors.lastname: Wang
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yu
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: De-Run Kong, Jin-Guang Wang, Chen Chen, Fang-Fang Yu, Qiong Wu, Jian-Ming Xu, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D004945:Esophagoscopy / Q000009:adverse effects; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D011312:Pressure; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012597:Sclerosing Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D015911:Sclerotherapy / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012597:Sclerosing Solutions; D011092:Polyethylene Glycols
keywords: Endoscopic injection sclerotherapy; Endoscopic variceal ligation; Variceal bleeding; Variceal pressure