title: Chemical composition and biological activities of the essential oil of Skimmia laureola leaves.
abstract: The composition of the essential oil from leaves of Skimmia laureola was determined by GC and GC-MS. Twenty-eight components were identified, accounting for 93.9% of the total oil. The oil is mainly composed of monoterpenes (93.5%), of which monoterpene hydrocarbons and oxygenated monoterpenes represent 11.0% and 82.5%, respectively. Sesquiterpenes constitute only 0.3% of the total oil. Linalyl acetate is the main component (50.5%), with linalool (13.1%), geranyl acetate (8.5%) and cis-p-menth-2-en-1-ol (6.2%) as other principal constituents. The essential oil showed a significant antispasmodic activity, in a dose range of 0.03-10 mg/mL. The essential oil also possesses antibacterial and antifungal activities against some pathogenic strains. The phytotoxic and cytotoxic activities were also assessed.
authors.affiliation: Department of Botany, University of Peshawar, Peshawar 25000, Pakistan. bu_barq@yahoo.com.
authors.lastname: Barkatullah
authors.affiliation: Department of Botany, University of Peshawar, Peshawar 25000, Pakistan. ibrarm200@yahoo.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ibrar
authors.affiliation: Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan. drnaveedrph@gmail.com.
authors.forename: Naveed
authors.initials: N
authors.lastname: Muhammad
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano 84084, Italy. defeo@unisa.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Feo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000737:chemistry* / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D010154:Pakistan; D010276:Parasympatholytics / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D011817:Rabbits; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D039821:Monoterpenes; D009822:Oils, Volatile; D010276:Parasympatholytics