title: [Gastrointestinal stromal tumours (GIST)--development in pathology, surgery and medical therapy. Developed during the 10th German GIST-meeting, Göttingen].
abstract: The first description of ligand-independent activating mutations in the KIT gene, which encodes the tyrosine-kinase KIT, greatly improved our understanding of gastrointestinal stromal tumour (GIST) biology. The therapeutic success in GIST has made tyrosine kinase inhibitors a "paradigm of targeted therapy". Deciphering resistance mechanisms in GIST has had implications for many other kinase-driven cancers. To exchange current knowledge within the field of GIST, the German GIST Meeting has taken place for now 10 years, traditionally in Göttingen. Subjects discussed include clinical diagnostics, pathology, surgery, and medical therapy. The following presentation gives an overview of the last meeting held in December 2013, including distinctive features in GIST and current data on the different topics.
authors.affiliation: Pathologie, Universität Erlangen.
authors.forename: A
authors.initials: A
authors.lastname: Agaimy
authors.affiliation: Innere Klinik (Tumorforschung), Universitätsklinik Essen.
authors.forename: S
authors.initials: S
authors.lastname: Bauer
authors.affiliation: Allgemein-Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen.
authors.forename: A
authors.initials: A
authors.lastname: Beham
authors.affiliation: Institut für Pathologie, Hamburg.
authors.forename: J
authors.initials: J
authors.lastname: Bertolini
authors.affiliation: Pathologie, Universität Erlangen.
authors.forename: F
authors.initials: F
authors.lastname: Haller
authors.affiliation: Medizinische Klinik IV, Universität Heidelberg.
authors.forename: R
authors.initials: R
authors.lastname: Koschny
authors.affiliation: Hämatologie und Hämostaseologie, Universität Leipzig.
authors.forename: J
authors.initials: J
authors.lastname: Maier
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, London.
authors.forename: M
authors.initials: M
authors.lastname: Montemurro
authors.affiliation: Allgemein-Viszeral- und Thoraxchirurgie, Universität Hamburg.
authors.forename: D
authors.initials: D
authors.lastname: Perez
authors.affiliation: Pathology, Brigham and Women's Hospital, Boston, MA.
authors.forename: I-M
authors.initials: IM
authors.lastname: Schaefer
authors.affiliation: Pathologie, Universitätsmedizin Göttingen.
authors.forename: H-U
authors.initials: HU
authors.lastname: Schildhaus
authors.affiliation: Allgemein- und Viszeralchirurgie, Universitätsklinikum Jena.
authors.forename: C
authors.initials: C
authors.lastname: Wurst
authors.affiliation: Gastroenterologie und Endokrinologie, Universitätsmedizin Göttingen.
authors.forename: S
authors.initials: S
authors.lastname: Cameron
mesh_terms: D013505:Digestive System Surgical Procedures / Q000379:methods*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000628:therapy*; D005858:Germany; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D012955:Societies, Medical