title: United Kingdom immune thrombocytopenia registry: retrospective evaluation of bone marrow fibrosis in adult patients with primary immune thrombocytopenia and correlation with clinical findings.
abstract: Fibrosis has been reported in some patients with immune thrombocytopenia (ITP) treated with thrombopoietin receptor agonists (TPO-RA). However, fibrosis has also been reported in patients with various stages of ITP, who were TPO-RA treatment-naïve. In our study, we looked for fibrosis in bone marrow trephine biopsies taken at initial diagnosis from 32 adult patients with ITP. Ten of the 32 evaluated samples (31·25%) showed increased reticulin (Grade 1-2 on Bauermeister scale and Grade 0-1 on the European Consensus scale), which showed a positive correlation with ethnicity (0·3%) but did not correlate with disease severity, any clinical features or co-morbidities.
authors.affiliation: Department of Pathology, Barts Health NHS Trust, London, UK; Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.
authors.forename: Hasan
authors.initials: H
authors.lastname: Rizvi
authors.forename: Tom
authors.initials: T
authors.lastname: Butler
authors.forename: Mariarita
authors.initials: M
authors.lastname: Calaminici
authors.forename: Indraraj U
authors.initials: IU
authors.lastname: Doobaree
authors.forename: Raghava C
authors.initials: RC
authors.lastname: Nandigam
authors.forename: Dimitri
authors.initials: D
authors.lastname: Bennett
authors.forename: Drew
authors.initials: D
authors.lastname: Provan
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Newland
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D053628:Receptors, Thrombopoietin / Q000819:agonists; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D006113:United Kingdom
chemical_list: D053628:Receptors, Thrombopoietin; C082218:MPL protein, human
keywords: bone marrow fibrosis; co-morbidities; collagen fibrosis; primary immune thrombocytopenia; reticulin fibrosis