title: Spinal pleomorphic xanthoastrocytoma companied with periventricular tumor.
abstract: Pleomorphic xanthoastrocytoma (PXA) is a low grade tumor that occurs in supratentorial area of children and young adult. In the previous reports, PXA of spinal cord or multicentre was extremely rare. A 60-year-old patient of spinal PXA and periventricular tumor presented with waist pain and weakness of double legs for one month. Neuroimaging showed that a lesion at the level of L2-L3 and periventricular tumor. Postoperative microscopy indicated that WHO grade II PXA. Photomicrograph of the lesion showed spindle cells, marked nuclear and cytoplasmic pleomorphism, with foamy cytoplasm. Immunohistochemical staining showed that GFAP and S-100 were positive. This is a rare case of synchronous multicentric PXA. Physicians should be realized multicentric dissemination by meninges or cerebrospinal fluid in PXA patients. It is important to describe the particular case in order to better understanding of clinical features.
authors.affiliation: Department of Neurosurgery, Yijishan Hospital, Wannan Medical College Wuhu, Anhui Province, P.R. China.
authors.forename: Xintong
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Yijishan Hospital, Wannan Medical College Wuhu, Anhui Province, P.R. China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Yijishan Hospital, Wannan Medical College Wuhu, Anhui Province, P.R. China.
authors.forename: Xiangming
authors.initials: X
authors.lastname: Wang
mesh_terms: D001254:Astrocytoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008161:Lumbosacral Region; D013120:Spinal Cord Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: Pleomorphic xanthoastrocytoma; multicentric tumor; spinal tumor