title: Evaluation of fibrogenic potential of industrial multi-walled carbon nanotubes in acute aspiration experiment.
abstract: Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.
authors.affiliation: Kazan State Medical University, Kazan, Russia.
authors.forename: T O
authors.initials: TO
authors.lastname: Khaliullin
authors.forename: A A
authors.initials: AA
authors.lastname: Shvedova
authors.forename: E R
authors.initials: ER
authors.lastname: Kisin
authors.forename: R R
authors.initials: RR
authors.lastname: Zalyalov
authors.forename: L M
authors.initials: LM
authors.lastname: Fatkhutdinova
mesh_terms: D000818:Animals; D018893:Bronchoalveolar Lavage; D005355:Fibrosis / Q000139:chemically induced / Q000276:immunology*; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D037742:Nanotubes, Carbon / Q000009:adverse effects*; D053495:Osteopontin / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D037742:Nanotubes, Carbon; D053773:Transforming Growth Factor beta1; D053495:Osteopontin