title: An unusual cause of generalised seizure following cardiac surgery: with bolus cefazolin administration.
abstract: Although some of the aetiological factors of seizure, such as cerebral microemboli, cerebral oedema, hypoperfusion, cerebral hypoxia and metabolic encephalopathy cannot be completely controlled during cardiac surgery, cautious management of all steps in the procedure may prevent the administrative causes of seizure. Cefazolin, which is known to be a proconvulsant agent, may be a suspected agent of seizure complications in patients with renal insufficiency. Surprisingly, intravenous bolus administration of cefazolin may also trigger seizure in patients with normal renal function. In this case report, a complication of generalised seizure after cardiac surgery with intravenous bolus administration of cefazolin is described, along with a brief review of the literature.
authors.affiliation: Department of Cardiovascular Surgery, Süleyman Demirel University, Isparta, Turkey. drkadirce@yahoo.com.
authors.forename: K
authors.initials: K
authors.lastname: Ceviker
authors.affiliation: Department of Neurology, Harran University, Sanliurfa, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Kocaturk
authors.affiliation: Cardiovascular Surgery, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Demir
mesh_terms: D061605:Administration, Intravenous; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000927:Anticonvulsants / Q000627:therapeutic use; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D002437:Cefazolin