title: Multipurpose prevention technologies: the future of HIV and STI protection.
abstract: Every day, more than 1 million people are newly infected with sexually transmitted infections (STIs) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (HIV) acquisition. Existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. This review summarizes important issues raised during a satellite session at the first HIV Research for Prevention (R4P) conference, held in Cape Town, on October 31, 2014. We explore key STIs that are challenging public health today, new biomedical prevention approaches including multipurpose prevention technologies (MPTs), and the scientific and regulatory hurdles that must be overcome to make combination prevention tools a reality.
authors.affiliation: Center for Biomedical Research, Population Council, New York, NY, United States.
authors.forename: José A
authors.initials: JA
authors.lastname: Fernández-Romero
authors.affiliation: National Institute of Allergy and Infectious Diseases, Bethesda MD, United States.
authors.forename: Carolyn
authors.initials: C
authors.lastname: Deal
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY, United States.
authors.forename: Betsy C
authors.initials: BC
authors.lastname: Herold
authors.affiliation: National Cancer Institute, Laboratory of Cellular Oncology, Bethesda, MD, United States.
authors.forename: John
authors.initials: J
authors.lastname: Schiller
authors.affiliation: University of Washington, Obstetrics & Gynecology, Seattle, WA, United States.
authors.forename: Dorothy
authors.initials: D
authors.lastname: Patton
authors.affiliation: Center for Biomedical Research, Population Council, New York, NY, United States.
authors.forename: Thomas
authors.initials: T
authors.lastname: Zydowsky
authors.affiliation: NWJ Group, LLC, United States.
authors.forename: Joe
authors.initials: J
authors.lastname: Romano
authors.affiliation: Albert Einstein College of Medicine, Bronx, NY, United States.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Petro
authors.affiliation: Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
authors.forename: Manjulaa
authors.initials: M
authors.lastname: Narasimhan
mesh_terms: D003267:Contraception; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D006558:Herpes Genitalis / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000517:prevention & control*; D049168:Pregnancy, Unplanned; D015995:Prevalence; D012749:Sexually Transmitted Diseases / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D013019:South Africa / Q000453:epidemiology; D014247:Trichomonas Vaginitis / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control
keywords: HIV; HPV; HSV-2; STI; Trichomonas vaginalis; multipurpose prevention technologies