title: Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study.
abstract: BACKGROUND
  Alopecia areata (AA) is an immune-mediated disease that targets anagen hair follicles. Despite various therapeutic options, there is no cure for AA. Prostaglandin analogues have been recognized as being capable of inducing hypertrichosis.
  
  
  OBJECTIVE
  To compare the efficacy and safety of bimatoprost to those of corticosteroid in the treatment of scalp AA.
  
  
  METHODS
  Thirty adult patients with patchy AA (S1) were included. Two AA patches were randomly assigned to treatment either by mometasone furoate 0.1% cream once daily (area A) or bimatoprost 0.03% solution twice daily (area B) for 3 months. Patients were assessed using the Severity of Alopecia Tool (SALT) scoring system for hair re-growth.
  
  
  RESULTS
  All responding AA patches showed significant reduction in their SALT score after therapy. Area B demonstrated significantly better results regarding rapidity of response in weeks, percentage of hair re-growth and side effects compared to area A.
  
  
  CONCLUSIONS
  Bimatoprost solution represents a therapeutic option for scalp AA.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors.forename: Hesham
authors.initials: H
authors.lastname: Zaher
authors.forename: Heba I
authors.initials: HI
authors.lastname: Gawdat
authors.forename: Rehab A
authors.initials: RA
authors.lastname: Hegazy
authors.forename: Marwa
authors.initials: M
authors.lastname: Hassan
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy*; D000069580:Bimatoprost / Q000009:adverse effects / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006197:Hair / Q000254:growth & development; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068656:Mometasone Furoate / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D011446:Prospective Studies; D012535:Scalp; D012720:Severity of Illness Index; D016037:Single-Blind Method; D063465:Skin Cream / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D000068656:Mometasone Furoate; D000069580:Bimatoprost