title: Uterine leiomyosarcoma with central nervous system metastases.
abstract: Leiomyosarcoma (LMS) is a rare tumour and comprises 2-3% of all malignant uterus neoplasms [1]. Leiomyosarcoma is characterised by aggressive behaviour, high recurrence rates, and poor overall survival, despite multimodal treatment [3]. Surgery is the main treatment and consists of total abdominal hysterectomy. A randomised trial consisting of 224 patients diagnosed with uterine sarcomas stage I and II showed that adjuvant radiotherapy improves locoregional control. The role of adjuvant chemotherapy is still unclear [1]. Unfortunately, roughly 50% of patients with organ-confined disease will usually develop distant metastasis to lung, peritoneum, liver, pelvic, and para-aortic lymph nodes. Brain metastases are extremely rare [5].
authors.affiliation: Centro Oncológico Antônio Ermírio de Moraes, Rua Maestro Cardim, 769, Bela Vista, São Paulo, Cep 01323-001, Brazil.
authors.forename: Carina Meira
authors.initials: CM
authors.lastname: Abrahão
authors.affiliation: Centro Oncológico Antônio Ermírio de Moraes, Rua Maestro Cardim, 769, Bela Vista, São Paulo, Cep 01323-001, Brazil.
authors.forename: Fernando Cotait
authors.initials: FC
authors.lastname: Maluf
keywords: central nervous system; leiomyosarcoma; metastasis