title: Biomechanical evaluation of Ti-Nb-Sn alloy implants with a low Young's modulus.
abstract: Dental implants are widely used and are a predictable treatment in various edentulous cases. Occlusal overload may be causally related to implant bone loss and a loss of integration. Stress concentrations may be diminished using a mechanobiologically integrated implant with bone tissue. The purpose of this study was to investigate the biomechanical behavior, biocompatibility and bioactivity of a Ti-Nb-Sn alloy as a dental implant material. It was compared with cpTi. Cell proliferation and alkaline phosphatase (ALP) activity were quantified. To assess the degree of osseointegration, a push-in test was carried out. Cell proliferation and ALP activity in the cells grown on prepared surfaces were similar for the Ti-Nb-Sn alloy and for cpTi in all the experiments. A comparison between the Ti-Nb-Sn alloy implant and the cpTi implant revealed that no significant difference was apparent for the push-in test values. These results suggest that implants fabricated using Ti-Nb-Sn have a similar biological potential as cpTi and are capable of excellent osseointegration.
authors.affiliation: Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. kenta@dent.tohoku.ac.jp.
authors.forename: Kenta
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. nshiraishi@dent.tohoku.ac.jp.|Division of Community Oral Health Science, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8573, Japan. nshiraishi@dent.tohoku.ac.jp.
authors.forename: Naru
authors.initials: N
authors.lastname: Shiraishi
authors.affiliation: Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. uzuka@dent.tohoku.ac.jp.
authors.forename: Risa
authors.initials: R
authors.lastname: Ishiko-Uzuka
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. anada@m.tohoku.ac.jp.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Anada
authors.affiliation: Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. suzuki-o@m.tohoku.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Suzuki
authors.affiliation: Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Aramaki aza Aoba 6-3, Aoba-ku, Sendai 980-8578, Japan. hiromasu@fris.tohoku.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masumoto
authors.affiliation: Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8577, Japan. keii@dent.tohoku.ac.jp.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000497:Alloys / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D055119:Elastic Modulus; D057927:Hydrophobic and Hydrophilic Interactions; D008297:Male; D051379:Mice; D009556:Niobium / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D013499:Surface Properties; D014001:Tin / Q000737:chemistry; D014025:Titanium / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D009556:Niobium; D014001:Tin; D014025:Titanium