title: Laparoscopic excision of ovarian endometrioma does not exert a qualitative effect on ovarian function: insights from in vitro fertilization and single embryo transfer cycles.
abstract: OBJECTIVE
  To evaluate whether laparoscopic excision of endometrioma exerts a qualitative effect on ovarian function.
  
  
  METHODS
  A retrospective analysis of oocytes retrieved in 25 cycles of 21 patients undergoing IVF treatment with controlled ovarian stimulation. The number of oocytes recovered from ovaries with a history of excision of endometrioma (E-Ov) were compared to those from contra-lateral healthy ovaries (H-Ov) as for the analysis of a quantitative effect of surgery. As for the analysis of a qualitative effect, 55 oocytes from E-Ov were compared to 128 oocytes from H-Ov in terms of normal fertilization rate and the rate of top-quality embryos per normally fertilized eggs. Furthermore, 10 embryos derived from oocytes recovered from E-Ov were compared to 24 embryos derived from oocytes from H-Ov in terms of clinical and on-going pregnancy rates per embryos in 34 single embryo transfer cycles.
  
  
  RESULTS
  Mean number of oocytes recovered from E-Ov was significantly smaller than that from H-Ov (2.2 ± 2.0 vs. 5.1 ± 3.3, P = 0.009). There was no difference between oocytes from E-Ov and H-Ov as for normal fertilization rate (63.6% vs. 69.5%, P = 0.43) and the rate of top-quality embryos (40.0% vs. 49.0%, P = 0.34). Clinical and on-going pregnancy rates per embryos were also similar in embryos derived from oocytes recovered from E-Ov and H-Ov (40.0% vs. 25.0%, P = 0.39 and 20.0% vs. 20.8%, P = 0.96).
  
  
  CONCLUSIONS
  The quality of oocytes recovered from the ovary with a history of laparoscopic excision of endometrioma is not inferior to the quality of oocytes from contra-lateral healthy ovary.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo, Tokyo, 113-8655, Japan, haradam-tky@umin.ac.jp.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Harada
authors.forename: Nozomi
authors.initials: N
authors.lastname: Takahashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hirata
authors.forename: Kaori
authors.initials: K
authors.lastname: Koga
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Fujii
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Osuga
mesh_terms: D000328:Adult; D004622:Embryo, Mammalian / Q000166:cytology*; D004715:Endometriosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D010535:Laparoscopy; D009865:Oocytes / Q000166:cytology; D010053:Ovary / Q000503:physiopathology / Q000601:surgery*; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011786:Quality Control; D012189:Retrospective Studies; D056826:Single Embryo Transfer