title: Generalized Multinucleate Cell Angiohistiocytoma.
abstract: BACKGROUND
  There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation.
  
  
  OBJECTIVE
  To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA.
  
  
  METHODS
  The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis.
  
  
  CONCLUSIONS
  Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.
authors.affiliation: Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS jaedoane@dal.ca.
authors.forename: Jennifer A E
authors.initials: JA
authors.lastname: Doane
authors.affiliation: Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS.
authors.forename: Kerri
authors.initials: K
authors.lastname: Purdy
authors.affiliation: Departments of Medicine and Pathology, Capital District Health Authority and Dalhousie University, Halifax, NS.
authors.forename: Sylvia
authors.initials: S
authors.lastname: Pasternak
mesh_terms: D000328:Adult; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology