title: The influence of spray cryotherapy on wound healing following endoscopic sinus surgery in chronic rhinosinusitis.
abstract: OBJECTIVE
  The aim of this study was to assess the influence of spray cryotherapy on wound healing following endoscopic sinus surgery (ESS).
  
  
  METHODS
  A prospective, randomized, double-blinded, controlled trial.
  
  
  METHODS
  The study included 22 consecutive adult patients with chronic rhinosinusitis with and without polyps scheduled for bilateral ESS. At the end of the surgical procedure, patients were randomized to the distribution of spray cryotherapy in one middle meatus and saline contralaterally. Outcomes were only measured for endoscopy scores. Thus, postoperative healing and the amount of edema, crusting, secretions, and scarring were assessed using the validated Lund-Kennedy and Perioperative Sinus Endoscopy (POSE) scores.
  
  
  RESULTS
  There were no baseline differences concerning POSE and Lund-Kennedy scores between the two groups. Nevertheless, a significant difference was recorded at one, 2, 4, 8, and 12 weeks in both POSE (P = .001, P = .012, P = .02, P = .006, P = .001) and Lund-Kennedy (P = .002, P = .005, P = .02, P = .02, P = .03) scores.
  
  
  CONCLUSIONS
  These preliminary results reveal an improvement in postoperative scores, demonstrating enhanced healing following spray cryotherapy. However, without patient subjective outcomes, the study is limited. Additional studies with longer follow-up and larger samples are needed to describe the effects of cryotherapy on wound healing.
authors.affiliation: IInd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Silviu
authors.initials: S
authors.lastname: Albu
authors.affiliation: IInd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Veronica
authors.initials: V
authors.lastname: Trombitas
authors.affiliation: IInd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
authors.forename: Diana
authors.initials: D
authors.lastname: Vlad
authors.affiliation: Department of Otorhinolaryngology and Otologic Surgery, Azienda Ospedaliera, Policlinico of Padua, University of Padua, Padua, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Emanuelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D017679:Cryotherapy / Q000379:methods*; D004311:Double-Blind Method; D004724:Endoscopy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D012220:Rhinitis / Q000628:therapy*; D012852:Sinusitis / Q000628:therapy*; D012965:Sodium Chloride / Q000008:administration & dosage*; D007507:Therapeutic Irrigation; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
chemical_list: D012965:Sodium Chloride
keywords: Wound healing; cryotherapy; endoscopic sinus surgery