title: lncRNA and gene looping: what's the connection?
abstract: Recent functional studies have unveiled the significant role chromatin topology plays in gene regulation. Several lines of evidence suggest genes access necessary factors for transcription by forming chromatin loops. A clearer picture of the players involved in chromatin organization, including lncRNA, is emerging.
authors.affiliation: a Gene Expression and Biophysics Group, Synthetic Biology Emerging Research Area, Biosciences Unit, Council for Scientific and Industrial Research; Pretoria, Gauteng, South Africa.
authors.forename: Youtaro
authors.initials: Y
authors.lastname: Shibayama
authors.forename: Stephanie
authors.initials: S
authors.lastname: Fanucchi
authors.forename: Loretta
authors.initials: L
authors.lastname: Magagula
authors.forename: Musa M
authors.initials: MM
authors.lastname: Mhlanga
mesh_terms: D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D062085:RNA, Long Noncoding / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism; D061785:Transcription Initiation, Genetic; D000097722:Cohesins
chemical_list: D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D062085:RNA, Long Noncoding; D012097:Repressor Proteins; D000097722:Cohesins; C000619697:CTCF protein, human
keywords: chromatin contact; chromatin loops; eRNA; enhancer; gene regulation; lncRNA; multigene complex; promoter; topologically associating domain; transcription