title: Morbidity and Mortality in Iranian Children with Juvenile Systemic Lupus erythematosus.
abstract: OBJECTIVE
  Juvenile systemic lupus erythematosus (JSLE) is a common rheumatologic disorder that involves multi organ systems. Prognosis of lupus in children may be poorer than in adults. In this study, we determined mortality and morbidity rates in the pediatric SLE in Iran.
  
  
  METHODS
  In a cross sectional study, we evaluated 120 children with SLE who had registered in our pediatric rheumatology database within 2004-2010. Data including sex, age, remission, age at the time of diagnosis, age at the time of study, various types of organ involvement, mortality and remission were extracted from this database. Findings : From 120 cases, 77% (92 cases) were females and 23% (28 cases) males (F:M=3.3). Mean follow up period was 56±32 months and mean age at the time of manifesting disease 10.34±2.9 years. Mortality rate was 10% (12 cases) in our investigation. Musculoskeletal involvement showed significant difference between various age groups (P<0.01), that was more frequent in group of 7 years and older. Frequency of oral ulcer and ophthalmic involvement in boys was significantly higher than in girls (P<0.05). Frequency of cardiovascular involvement (P<0.01) and renal involvement (P<0.01) was significantly higher in the patients who had no remission. There was a significant association between mortality rate and cardiac (P<0.02, OR=4.9), pulmonary (P<0.01, OR=10.167) and liver (P<0.05, OR=1.19) involvement.
  
  
  CONCLUSIONS
  In our investigation 1-year survival rate was 97% and 5-year survival rate 89%. Liver, cardiac and pulmonary involvements have an association with higher mortality in JSLE patients.
authors.affiliation: Growth and Development Research Center.
authors.forename: Fariba
authors.initials: F
authors.lastname: Tavangar-Rad
authors.affiliation: Pediatric Rheumatology Research Group, Rheumatology Research Center ; Department of Pediatrics, Tehran University of Medical Sciences ; Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Ziaee
authors.affiliation: Department of Pediatrics, Tehran University of Medical Sciences ; Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran.
authors.forename: Mohammad-Hassan
authors.initials: MH
authors.lastname: Moradinejad
authors.affiliation: Department of Pediatrics, Tehran University of Medical Sciences ; Children's Medical Center, Pediatrics Center of Excellence, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Tahghighi
keywords: Children; Iran; Juvenile; Morbidity; Mortality; Systemic Lupus Erythematosus