title: Regioselective access to CF₃S-substituted dihydrofurans from homopropargylic alcohols with trifluoromethanesulfenamide.
abstract: A facile access to 4-((trifluoromethyl)thio)-2,3-dihydrofurans from unprotected homopropargylic alcohols in high regioselectivity is reported. This method is the first example of using a free hydroxy group as a nucleophile to complete a trifluoromethylthiolation/cyclization protocol with an alkyne in moderate to excellent yields.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China. liuxuey@lzu.edu.cn.
authors.forename: Dao-Qian
authors.initials: DQ
authors.lastname: Chen
authors.forename: Pin
authors.initials: P
authors.lastname: Gao
authors.forename: Ping-Xin
authors.initials: PX
authors.lastname: Zhou
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Qiu
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000577:Amides; D000814:Aniline Compounds; D005663:Furans; D020005:Propanols; D013440:Sulfides; C028255:propargyl alcohol