title: Correlation between relaxometry and diffusion tensor imaging in the globus pallidus of Huntington's disease patients.
abstract: Huntington's disease (HD) is an inherited neurodegenerative disorder with progressive impairment of motor, behavioral and cognitive functions. The clinical features of HD are closely related to the degeneration of the basal ganglia, predominantly the striatum. The main striatal output structure, the globus pallidus, strongly accumulates metalloprotein-bound iron, which was recently shown to influence the diffusion tensor scalar values. To test the hypothesis that this effect dominates in the iron-rich basal ganglia of HD patients, we examined the globus pallidus using DTI and T2 relaxometry sequences. Quantitative magnetic resonance (MR), clinical and genetic data (number of CAG repeats) were obtained from 14 HD patients. MR parameters such as the T2 relaxation rate (RR), fractional anisotropy (FA) and mean diffusivity (MD) were analysed. A positive correlation was found between RR and FA (R2=0.84), between CAG and RR (R2=0.59) and between CAG and FA (R2=0.44). A negative correlation was observed between RR and MD (R2=0.66). A trend towards correlation between CAG and MD was noted. No correlation between MR and clinical parameters was found. Our results indicate that especially magnetic resonance FA measurements in the globus pallidus of HD patients may be strongly affected by metalloprotein-bound iron accumulation.
authors.affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; International Clinical Research Center, St. Anne´s University Hospital, Brno, Czech Republic; Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.
authors.forename: Michael
authors.initials: M
authors.lastname: Syka
authors.affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; Department of Neurology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Keller
authors.affiliation: Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine and General University Hospital in Prague, Charles University in Prague, Prague, Czech Republic; Institute of Anatomy, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Klempíř
authors.affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic; Department of Radiology, 1st Faculty of Medicine and General University Hospital in Prague, Charles University in Prague, Prague, Czech Republic.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Rulseh
authors.affiliation: Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine and General University Hospital in Prague, Charles University in Prague, Prague, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Roth
authors.affiliation: Department of Neurology and Center of Clinical Neuroscience, 1st Faculty of Medicine and General University Hospital in Prague, Charles University in Prague, Prague, Czech Republic.
authors.forename: Robert
authors.initials: R
authors.lastname: Jech
authors.affiliation: Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic.
authors.forename: Ivan
authors.initials: I
authors.lastname: Vorisek
authors.affiliation: Department of Radiology, Na Homolce Hospital, Prague, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Vymazal
mesh_terms: D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D042622:DNA Repeat Expansion; D056324:Diffusion Tensor Imaging; D005260:Female; D005917:Globus Pallidus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000473:pathology*; D007501:Iron / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
chemical_list: D007501:Iron