title: Meeting current musculoskeletal health demand through deeper insights into tissue homeostasis and regeneration.
abstract: The burden of chronic musculoskeletal disorders is challenging and prompts therapeutic advancements. The notion that chronic conditions such as osteoarthritis and tendinopathy are linked to deficient healing by failure of one or several of the cellular/molecular processes involved is gaining ground. Alterations underpinning disruption of healing mechanisms that contribute to the development of chronic musculoskeletal pathologies include unresolved inflammation, abnormal angiogenic status, alterations in paracrine communication, decline in stem cell functioning and inability to maintain homeostasis in the extracellular matrix compartment. The complexity of failed healing may be challenged with interventions that target multiple biological processes such as cell therapies and/or platelet-rich plasma.
authors.affiliation: BioCruces Health Research Institute/Cruces University Hospital, Regenerative Medicine , Pza Cruces, Barakaldo 48903 , Spain iandia2010@hotmail.com.
authors.forename: Isabel
authors.initials: I
authors.lastname: Andia
authors.forename: Nicola
authors.initials: N
authors.lastname: Maffulli
mesh_terms: D048091:Guided Tissue Regeneration / Q000639:trends; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D009140:Musculoskeletal Diseases / Q000503:physiopathology* / Q000628:therapy*; D010003:Osteoarthritis / Q000503:physiopathology / Q000628:therapy; D053657:Platelet-Rich Plasma / Q000502:physiology; D012038:Regeneration / Q000502:physiology*; D052256:Tendinopathy / Q000503:physiopathology / Q000628:therapy; D014945:Wound Healing / Q000502:physiology
keywords: cell therapies; osteoarthritis; platelet-rich plasma; tendinopathy; tissue healing