title: High Expression of Mannose-Binding Lectin and the Risk of Vascular Complications of Diabetes: Evidence from a Meta-Analysis.
abstract: BACKGROUND
  Vascular inflammation associated with mannose-binding lectin (MBL) may be implicated in the pathogenesis of vascular complications in diabetes. The purpose of this study is to evaluate the association of MBL expression with vascular complications in diabetes.
  
  
  METHODS
  Data from published case-control studies on MBL expression and vascular complications of diabetes were collected up to September 30, 2014. Medline, Embase, and Chinese National Knowledge Infrastructure (CNKI) were searched using the key words "MBL or mannose-binding lectin or mannan-binding lectin," "diabetes or diabetic," and "vascular complication, vascular disease or angiopathy" to identify the articles published in English or Chinese.
  
  
  RESULTS
  The combined odds ratio (OR) and 95% confidence interval (CI) for the cumulative rate of vascular complications in the cases of high-expression MBL versus that in cases of low-expression MBL were estimated using a fixed-effects model and a random-effects model. In total, 2,714 cases from 12 articles including 2,256 cases with high-expression MBL (≥ 400 μg/L) and 458 cases with low-expression MBL (< 400 μg/L) were reviewed. The cumulative vascular complication rates were 52.9% (1,194/2,256) in the cases with high expression and 38.4% (176/458) in those with low expression. The combined ORs were 1.6, with a 95% CI ranging from 1.24 to 2.08, in the fixed-effects model and 1.94, with a 95% CI from 1.00 to 3.76, in the random-effects model.
  
  
  CONCLUSIONS
  High expression of MBL may be correlated with a significantly increased risk of vascular complications in diabetes. Thus MBL detection in diabetes is an effective and feasible method to predict vascular complications.
authors.affiliation: 1 Microbiology and Immunology, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: 2 Epidemiology and Biostatistics Department, School of Public Health, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: WeiYan
authors.initials: W
authors.lastname: Lin
authors.affiliation: 3 Clinical Laboratory , Wanjiang Hospital of Dongguan, Dongguan, Guangdong, China .
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.affiliation: 4 Traditional Chinese Medicine and New Drug Research Institute, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: JianTao
authors.initials: J
authors.lastname: Lin
authors.affiliation: 5 Cancer Institute of Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: Sen
authors.initials: S
authors.lastname: Wang
authors.affiliation: 6 Pathology Departments, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.affiliation: 2 Epidemiology and Biostatistics Department, School of Public Health, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: JinDong
authors.initials: J
authors.lastname: Ni
authors.affiliation: 1 Microbiology and Immunology, Guangdong Medical College , Dongguan, Guangdong, China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D048909:Diabetes Complications / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000209:etiology*; D006801:Humans; D037601:Mannose-Binding Lectin / Q000378:metabolism*; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D037601:Mannose-Binding Lectin