title: In vivo imaging of human photoreceptor mosaic with wavefront sensorless adaptive optics optical coherence tomography.
abstract: Wavefront sensorless adaptive optics optical coherence tomography (WSAO-OCT) is a novel imaging technique for in vivo high-resolution depth-resolved imaging that mitigates some of the challenges encountered with the use of sensor-based adaptive optics designs. This technique replaces the Hartmann Shack wavefront sensor used to measure aberrations with a depth-resolved image-driven optimization algorithm, with the metric based on the OCT volumes acquired in real-time. The custom-built ultrahigh-speed GPU processing platform and fast modal optimization algorithm presented in this paper was essential in enabling real-time, in vivo imaging of human retinas with wavefront sensorless AO correction. WSAO-OCT is especially advantageous for developing a clinical high-resolution retinal imaging system as it enables the use of a compact, low-cost and robust lens-based adaptive optics design. In this report, we describe our WSAO-OCT system for imaging the human photoreceptor mosaic in vivo. We validated our system performance by imaging the retina at several eccentricities, and demonstrated the improvement in photoreceptor visibility with WSAO compensation.
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada ; These authors contributed equally to this work.
authors.forename: Kevin S K
authors.initials: KS
authors.lastname: Wong
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada ; These authors contributed equally to this work.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Jian
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Cua
authors.affiliation: CNR-Institute of Photonics and Nanotechnology, via Trasea 7, 35131, Padova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
authors.affiliation: UC Davis RISE Small Animal Ocular Imaging Facility, Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616 USA ; Vision Science and Advanced Retinal Imaging laboratory (VSRI), Department of Ophthalmology & Vision Science, University of California Davis, Sacramento, CA 95817 USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6 Canada.
authors.forename: Marinko V
authors.initials: MV
authors.lastname: Sarunic
keywords: (010.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (120.3890) Medical optics instrumentation; (170.0110) Imaging systems; (170.4470) Ophthalmology; (220.1000) Aberration compensation