title: Effective components ofPanax quinquefoliusandCorydalis tuberprotect the myocardium by inhibiting platelet activation and improving the hypercoagulable state.
abstract: The aim of the present study was to investigate the effects of extract ofPanax quinquefoliusandCorydalis tuber(EPC) on platelet activation and the hypercoagulable state in rats with acute myocardial infarction (AMI). The MI model in Wistar rats was induced by coronary artery ligation. Sham surgery was performed as a control. The surviving rats that underwent MI surgery were divided into control (administered normal saline), metoprolol (9 mg/kg) and low-, moderate- and high-dose EPC groups (0.54, 1.08 g/kg and 2.16 g/kg, respectively). Saline, metoprolol and EPC were administered by gastrogavage for two consecutive weeks. The morphological changes of the myocardium were assessed by hematoxylin and eosin and nitroblue tetrazolium staining. Serum von Willebrand factor (vWF), D-dimer (DD), platelet membrane glycoproteins IIb-IIIa (GPIIb-IIIa) and CD62P levels were assessed using enzyme-linked immunosorbent assay. EPC attenuated the pathological changes of the myocardium. High-dose EPC decreased the serum concentration of vWF when compared with control group. Moderate and high doses of EPC decreased the DD and GPIIb-IIIa levels, and the CD62P level was gradually decreased with EPC dose escalation. The results therefore demonstrated that EPC protects the myocardium by inhibiting platelet activation and improving the hypercoagulable state in a rat model of AMI.
authors.affiliation: Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian, Beijing 100091, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.affiliation: Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, P.R. China.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Liu
authors.affiliation: Department of Geriatric Medicine, Peking University First Hospital, Beijing 100034, P.R. China.
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Zhu
authors.affiliation: Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian, Beijing 100091, P.R. China.
authors.forename: DA-Zhuo
authors.initials: DZ
authors.lastname: Shi
authors.affiliation: Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian, Beijing 100091, P.R. China.
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Yin
keywords: Corydalis tuber; Panax quinquefolius; acute myocardial infarction; hypercoagulable state; platelet activation