title: New frontiers for platelet CD154.
abstract: The role of platelets extends beyond hemostasis. The pivotal role of platelets in inflammation has shed new light on the natural history of conditions associated with acute or chronic inflammation. Beyond the preservation of vascular integrity, platelets are essential to tissue homeostasis and platelet-derived products are already used in the clinics. Unanticipated was the role of platelets in the adaptative immune response, allowing a renewed conceptual approach of auto-immune diseases. Platelets are also important players in cancer growth and dissemination. Platelets fulfill most of their functions through the expression of still incompletely characterized membrane-bound or soluble mediators. Among them, CD154 holds a peculiar position, as platelets represent a major source of CD154 and as CD154 contributes to most of these new platelet attributes. Here, we provide an overview of some of the new frontiers that the study of platelet CD154 is opening, in inflammation, tissue homeostasis, immune response, hematopoiesis and cancer.
authors.affiliation: INSERM U1026, and Université de Bordeaux, F-33000 Bordeaux, France ; Service d'Anesthésie-Réanimation II, CHU de Bordeaux, F-33600 Pessac, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Dewitte
authors.affiliation: INSERM U1026, and Université de Bordeaux, F-33000 Bordeaux, France.
authors.forename: Annabelle
authors.initials: A
authors.lastname: Tanga
authors.affiliation: Cell and Developmental Biology Programme, Centre for Genomic Regulation, 08003 Barcelona, Spain ; Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720-3200 USA.
authors.forename: Julien
authors.initials: J
authors.lastname: Villeneuve
authors.affiliation: INSERM U1026, and Université de Bordeaux, F-33000 Bordeaux, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lepreux
authors.affiliation: Service d'Anesthésie-Réanimation II, CHU de Bordeaux, F-33600 Pessac, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Ouattara
authors.affiliation: EA 6309, University of Limoges, F-87025 Limoges, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Desmoulière
authors.affiliation: INSERM U1026, and Université de Bordeaux, F-33000 Bordeaux, France ; Service de Néphrologie Transplantation Dialyse, CHU de Bordeaux, F-33076 Bordeaux, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Combe
authors.affiliation: INSERM U1026, and Université de Bordeaux, F-33000 Bordeaux, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Ripoche
keywords: CD154; Platelets