title: Effects of VEGF and MSCs on vascular regeneration in a trauma model in rats.
abstract: In the human body, vascular injuries that are caused by trauma, vessel lumen stenosis, and occlusions are often irreversible and can lead to sequelae formation as the vessels cannot reproduce fast enough. To solve this problem, the blood flow must be returned to the region as fast as possible. The adipose tissue contains progenitor cells with angiogenic potential and can be used to resolve the issue. In the present study, mesenchymal stem cells (MSCs) derived from rat adipose tissue, vascular endothelial growth factor (VEGF), and their mixture were applied on the dorsum of a rat, which was traumatized and its contribution to vascular regeneration was reviewed. No application was made to the control group. The results showed that the percentage of necrotic area was significantly lower in the MSC group than that of all the other groups. When the VEGF group was compared to the VEGF + MSCs, the percentage of necrotic area was observed to be similiar. However, VEGF showed effects only when a large quantites of VEGF was applied to the flap area. VEGF could not fully respond to the needs, whereas MSCs can produce VEGF according to the needs of tissue. This makes them superior to stem cells.
authors.affiliation: Department of Cardiovascular Surgery, Muş State Hospital, Muş, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Niyaz
authors.affiliation: Faculty of Science, Department of Biology, Hacettepe University, Ankara, Turkey.
authors.forename: Özer Aylin
authors.initials: ÖA
authors.lastname: Gürpınar
authors.affiliation: Faculty of Medicine, Department of Cardiovascular Surgery, Gazi University, Ankara, Turkey.
authors.forename: Gürsel Levent
authors.initials: GL
authors.lastname: Oktar
authors.affiliation: Department of Cardiovascular Surgery, Medline Eskişehir Hospital, Eskişehir, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Günaydın
authors.affiliation: Faculty of Science, Department of Biology, Hacettepe University, Ankara, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Onur
authors.affiliation: Department of Cardiovascular Surgery, Bursa Training and Reseach Hospital, Bursa, Turkey.
authors.forename: Kadir Kaan
authors.initials: KK
authors.lastname: Özsin
authors.affiliation: Faculty of Medicine, Department of Cardiovascular Surgery, Gazi University, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yener
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D008297:Male; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology*; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology*
chemical_list: D042461:Vascular Endothelial Growth Factor A