title: Sentinel node mapping in Marjolin's ulcers: is it feasible?
abstract: BACKGROUND
  This study evaluated the feasibility of sentinel node biopsy in Marjolin's ulcers using peritumoral injection of the radiotracer and blue dye.
  
  
  METHODS
  Ten patients with Marjolin's ulcers (5 male and 5 females) ranging in age from 39-65 years, and who were candidates for surgical removal of their tumors, were included in this study. The patients received 2 mCi technetium 99m (99mTc) antimony sulfide colloid in 2 divided doses subcutaneously in the peritumoral region. Immediately after anesthesia induction, 1 cc patent blue V in 2 divided doses was also injected in the same fashion as the radiotracer. Lymphatic mapping and sentinel node biopsy was performed using a gamma probe. Any hot and/or blue lymph nodes were harvested as a sentinel node. Primary lesions were then excised and wounds grafted with a splitthickness skin graft.
  
  
  RESULTS
  A sentinel node could be identified on the lymphoscintigraphy images in only 2 patients. Sentinel node mapping was successful during surgery in these 2 patients. None of the harvested sentinel nodes were blue.
  
  
  CONCLUSIONS
  Lymphatic mapping and sentinel node biopsy do not seem feasible in Marjolin's ulcers located in areas of extensive burn scarring due to a low detection rate. Larger studies are needed to validate the results of this study.
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Motamedolshariati
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ezatollah
authors.initials: E
authors.lastname: Rezaei
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Beiraghi-Toosi
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Jahani
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Tayyebi Meibodi
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Asiehsadat
authors.initials: A
authors.lastname: Fattahi
authors.affiliation: Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Sadeghi
mesh_terms: D000328:Adult; D000368:Aged; D002056:Burns / Q000150:complications / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011446:Prospective Studies; D018570:Risk Assessment; D012394:Rosaniline Dyes; D012494:Sampling Studies; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D012883:Skin Ulcer / Q000209:etiology / Q000473:pathology*
chemical_list: D012394:Rosaniline Dyes; C008769:sulfan blue