title: Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model.
abstract: A rat model of Parkinson's disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson's disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson's disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China ; Shenzhen Institute of Gerontology, Second Clinical Medical College, Jinan University, Shenzhen 518020, Guangdong Province, China.
authors.forename: Zhengzhi
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Gao
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.
authors.forename: Anmin
authors.initials: A
authors.lastname: Wu
authors.affiliation: Larry Hillblom Islet Research Center, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA.
authors.forename: Andrew C J
authors.initials: AC
authors.lastname: Huang
keywords: Anchanling; Parkinson's disease; cell apoptosis; tyrosine hydroxylase; ubiquitin-proteasome system; α-synuclein