title: Survival benefit for adjuvant radiation therapy in minor salivary gland cancers.
abstract: OBJECTIVE
  The goal of the current study is to investigate the role of adjuvant radiation therapy (adjuvant RT) in minor salivary gland tumors (mSGT) using an established national database.
  
  
  METHODS
  The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients treated with or without adjuvant RT for mSGT from 1988 to 2008. Regression analyses were performed to identify factors associated with improved overall survival (OS).
  
  
  RESULTS
  Most tumors were located within the oral cavity (75%) followed by nasal cavity/paranasal sinuses (15%). Multivariate Cox analysis showed that adjuvant RT was associated with better OS compared to surgery alone. Using logistic regression analysis, we provide a novel web based tool for predicting survival impact of adjuvant RT in patients with mSGT.
  
  
  CONCLUSIONS
  Adjuvant RT is associated with improved survival in patients with mSGT and adverse clinicopathologic factors such as advanced T/N category, adenoid cystic histology, high grade, and nasopharynx location.
authors.affiliation: Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, United States. Electronic address: zeidan@miami.edu.
authors.forename: Youssef H
authors.initials: YH
authors.lastname: Zeidan
authors.affiliation: Department of Statistics, Stanford University, Stanford, CA, United States.
authors.forename: Leonid
authors.initials: L
authors.lastname: Pekelis
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, United States.
authors.forename: Yi
authors.initials: Y
authors.lastname: An
authors.affiliation: Division of Head & Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine, Stanford, CA, United States.
authors.forename: Floyd Christopher
authors.initials: FC
authors.lastname: Holsinger
authors.affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.
authors.forename: Christina S
authors.initials: CS
authors.lastname: Kong
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States.
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Chang
authors.affiliation: Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States.
authors.forename: Quynh-Thu
authors.initials: QT
authors.lastname: Le
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012468:Salivary Gland Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D016019:Survival Analysis; D055815:Young Adult
keywords: Head and neck; Minor salivary gland; Postoperative; Radiotherapy; SEER; Survival