title: Alveolar bone loss induced by chronic ethanol consumption from adolescence to adulthood in Wistar rats.
abstract: Though there are literature indicating the bone loss due to alcohol consumption, studies on the association between ethanol consumption and periodontal breakdown in animals are either scarce or have provided conflicting results. Here, we investigated the effects of chronic alcohol exposure from adolescence to adulthood on the alveolar bone in rats. Wistar rats were exposed to ethanol (6.5 g/kg/day) in a solution of 22.5% (w/v) or distilled water (control) by gavage from 35 days of age (adolescent) until 90 days (adulthood). Evaluation of the bone loss was performed using scanning electronic microscopy, in which the distances between the cement-enamel junction and the alveolar bone crest from the palatal side of the first molar mandibular were measured. The measurements obtained were tabulated and analyzed using Student's t-test. Alcohol-treated group revealed greater bone loss in comparison to the control group. These findings indicate that heavy chronic alcohol exposure from adolescent to adulthood can induce alveolar bone loss in rats associated to absence of periodontitis.
authors.forename: Ster Vogel
authors.initials: SV
authors.lastname: Bannach
authors.forename: Francisco Bruno
authors.initials: FB
authors.lastname: Teixeira
authors.forename: Luanna Melo Pereira
authors.initials: LM
authors.lastname: Fernandes
authors.forename: Railson Oliveira
authors.initials: RO
authors.lastname: Ferreira
authors.forename: Luana Nazaré da Silva
authors.initials: LN
authors.lastname: Santana
authors.forename: Enéas Andrade
authors.initials: EA
authors.lastname: Fontes-Júnior
authors.forename: Gedeão Batista
authors.initials: GB
authors.lastname: Oliveira
authors.forename: Rui Daniel
authors.initials: RD
authors.lastname: Prediger
mesh_terms: D000367:Age Factors; D016301:Alveolar Bone Loss / Q000139:chemically induced* / Q000175:diagnosis; D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000633:toxicity; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008336:Mandibular Diseases / Q000139:chemically induced* / Q000175:diagnosis; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol