title: IGF-Binding Protein 2 - Oncogene or Tumor Suppressor?
abstract: The role of insulin-like growth factor binding protein 2 (IGFBP2) in cancer is unclear. In general, IGFBP2 is considered to be oncogenic and its expression is often observed to be elevated in cancer. However, there are a number of conflicting reports in vitro and in vivo where IGFBP2 acts in a tumor suppressor manner. In this mini-review, we discuss the factors influencing the variation in IGFBP2 expression in cancer and our interpretation of these findings.
authors.affiliation: Centre for Cancer Research and Cell Biology, Queen's University , Belfast , UK.
authors.forename: Adam
authors.initials: A
authors.lastname: Pickard
authors.affiliation: Centre for Cancer Research and Cell Biology, Queen's University , Belfast , UK.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: McCance
keywords: IGF-II; IGF1; IGF2; IGFBP2; IGFBPs; IGFI; oncogenes; tumour suppressor