title: The next steps in cervical screening.
abstract: Cervical cancer is fourth most common cancer among women with four-fifths of the global burden in low- and middle-income countries (LMICs). Persistent infection with one of the high-risk types of human papillomaviruses (HPV), particularly HPV 16/18, is the central cause of cervical neoplasia. Progress in developing feasible, alternative screening methods in LMICs and HPV vaccines have further improved cervical cancer prevention prospects. While existing screening programs in high-income countries should be re-organized, in view of the downstream effects of national HPV vaccination programs, LMICs should introduce national programs to vaccinate single year cohorts of girls aged 9-13 years with two or three doses and screen 30-35-year-old women with HPV testing to pragmatically decrease their high disease burden.
authors.affiliation: Section of Early Detection & Prevention, International Agency for Research on Cancer, Lyon, France.
authors.forename: Rengaswamy
authors.initials: R
authors.lastname: Sankaranarayanan
authors.forename: You-lin
authors.initials: YL
authors.lastname: Qiao
authors.forename: Namory
authors.initials: N
authors.lastname: Keita
mesh_terms: D003906:Developing Countries; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D014943:Global Health; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000821:virology*; D016387:Women's Health
chemical_list: D053918:Papillomavirus Vaccines
keywords: HPV testing; HPV vaccination; VIA; cancer; cervix; cytology; natural history; precancerous lesions; prevention; screening