title: Transcription gets to the checkpoint.
abstract: The rapid cell proliferation characteristic of early animal embryos is accomplished with an abbreviated cell cycle and no DNA replication checkpoint. Blythe and Wieschaus provide evidence that nascent zygotic transcription precedes—and may trigger—this checkpoint at the midblastula transition.
authors.affiliation: Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S1A8, Canada.
authors.forename: John D
authors.initials: JD
authors.lastname: Laver
authors.affiliation: Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S1A8, Canada. Electronic address: howard.lipshitz@utoronto.ca.
authors.forename: Howard D
authors.initials: HD
authors.lastname: Lipshitz
mesh_terms: D000818:Animals; D004261:DNA Replication; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics*; D005260:Female; D008297:Male; D015053:Zygote / Q000378:metabolism*