title: Our interface with the built environment: immunity and the indoor microbiota.
abstract: The rise of urbanization and an increasingly indoor lifestyle has affected human interactions with our microbiota in unprecedented ways. We discuss how this lifestyle may influence immune development and function, and argue that it is time that we examined ways to manipulate the indoor environment to increase our exposure to a wider phylogeny of microorganisms. An important step is to continue to engage citizen scientists in the efforts to characterize our interactions with the diverse microbial environments that we inhabit.
authors.affiliation: Institute for Genomic and Systems Biology, Biosciences Department, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Lax
authors.affiliation: Committee on Immunology, Department of Pathology, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
authors.forename: Cathryn R
authors.initials: CR
authors.lastname: Nagler
authors.affiliation: Institute for Genomic and Systems Biology, Biosciences Department, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA; Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA; Marine Biological Laboratory, 7 MBL Street, Woods Hole, MA 02543, USA; College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: gilbertjack@anl.gov.
authors.forename: Jack A
authors.initials: JA
authors.lastname: Gilbert
mesh_terms: D018504:Ecological Systems, Closed; D004777:Environment; D004779:Environment Design / Q000639:trends; D006801:Humans; D007109:Immunity; D033181:Information Dissemination; D054892:Metagenome / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D061108:Social Media; D013559:Symbiosis / Q000276:immunology*; D014507:Urbanization / Q000639:trends
keywords: built environment; microbiome