title: Aminobenzoic acid incorporated octapeptides for cation transport.
abstract: Robust oligopeptides that mimic natural ion channels are attractive for use as molecular switches or model systems to study ion transport. Herein, we report octapeptides derived from aminobenzoic acid and l/d amino acids. Two of the alanine containing peptides were found to be most active and the peptide containing p-aminobenzoic acid was found to be most active (2.4 times its m-analog). Experimental studies indicate the peptides do not transport halides and transport alkali metal ions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
authors.forename: Bahiru P
authors.initials: BP
authors.lastname: Benke
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address: nanditam@iitm.ac.in.
authors.forename: Nandita
authors.initials: N
authors.lastname: Madhavan
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry* / Q000378:metabolism*; D002412:Cations; D017136:Ion Transport / Q000502:physiology; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D002412:Cations; D009842:Oligopeptides; D010129:4-Aminobenzoic Acid
keywords: Carriers; Channel; Ion transporters; Peptides; Pores