title: Synthesis of oxazolidine-2,4-diones by a tandem phosphorus-mediated carboxylative condensation-cyclization reaction using atmospheric carbon dioxide.
abstract: The oxazolidine-2,4-dione motif is found frequently in biologically important compounds. A tandem phosphorus-mediated carboxylative condensation of primary amines and α-ketoesters/base-catalyzed cyclization reaction have been developed. These processes provide a novel and convenient access to various oxazolidine-2,4-diones in a one-pot fashion using atmospheric carbon dioxide and readily available substrates under very mild and transition-metal-free conditions.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, 116012, P. R. China. zhangwz@dlut.edu.cn.
authors.forename: Wen-Zhen
authors.initials: WZ
authors.lastname: Zhang
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
authors.forename: Xu-Tong
authors.initials: XT
authors.lastname: Yang
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Lu
mesh_terms: D000588:Amines / Q000737:chemistry; D001272:Atmosphere / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry*
chemical_list: D000588:Amines; D004952:Esters; D023303:Oxazolidinones; D002245:Carbon Dioxide; D010758:Phosphorus; D000432:Methanol