title: Extract of Rhus verniciflua stokes protects the diet-induced hyperlipidemia in mice.
abstract: Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXRα. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.
authors.affiliation: Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Se-Jin
authors.initials: SJ
authors.lastname: Jeong
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA.
authors.forename: Jong-Gil
authors.initials: JG
authors.lastname: Park
authors.affiliation: Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Sinai
authors.initials: S
authors.lastname: Kim
authors.affiliation: Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Hyae Yon
authors.initials: HY
authors.lastname: Kweon
authors.affiliation: Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Seungwoon
authors.initials: S
authors.lastname: Seo
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
authors.forename: Dae-Seung
authors.initials: DS
authors.lastname: Na
authors.affiliation: College of Life Sciences and Biotechnology, Korea University, Seoul, 136-713, Republic of Korea.
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.affiliation: Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd, Gyeonggi-Do, Republic of Korea.
authors.forename: Cheol Yi
authors.initials: CY
authors.lastname: Hong
authors.affiliation: Lifetree Biotechnology Institute, Lifetree Biotech Co. Ltd, Gyeonggi-Do, Republic of Korea.
authors.forename: Chun-Soo
authors.initials: CS
authors.lastname: Na
authors.affiliation: School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Dong
authors.affiliation: Immune and Vascular Cell Network Research Center, National Creative Initiatives, Department of Life Sciences and GT5 Program, Ewha Womans University, Seoul, Republic of Korea. gootaeg@ewha.ac.kr.
authors.forename: Goo Taeg
authors.initials: GT
authors.lastname: Oh
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002784:Cholesterol / Q000096:biosynthesis; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D066273:Diet, Western / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000517:prevention & control*; D008055:Lipids / Q000096:biosynthesis; D000071518:Liver X Receptors; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D057093:Orphan Nuclear Receptors / Q000235:genetics; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D029045:Rhus / Q000737:chemistry*
chemical_list: D001647:Bile Acids and Salts; D008055:Lipids; D000071518:Liver X Receptors; C000605214:Nr1h3 protein, mouse; D057093:Orphan Nuclear Receptors; D010936:Plant Extracts; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase; C502772:Cyp7a1 protein, mouse
keywords: Bile acid biosynthesis; Cyp7a1; Hyperlipidemia; Liver X receptor α (LXRα); Rhus verniciflua stokes (RVS)