title: Increased cause-specific mortality in patients with mild and severe psoriasis: a population-based Swedish register study.
abstract: Several studies have shown excess risk for a number of comorbidities in patients with psoriasis compared with the general population, but data on cause-specific mortality in this patient population are limited. The aim of this study was to estimate the associations of psoriasis and 12 specific causes of death and all-cause mortality in patients with mild and severe psoriasis. The study was based on data from Swedish administrative registers and compared the risk of death in 39,074 patients with psoriasis with 154,775 sex-, age- and residency-matched referents using Cox proportional hazards models. In patients with mild and severe psoriasis, the strongest associations were observed for deaths due to kidney disease (hazard ratio [HR]=2.20, p < 0.01) and liver disease (HR = 4.26, p < 0.001), respectively. Whilst cardiovascular disease was the main driver of excess mortality in absolute terms, the risks for other causes of death were also substantially elevated in patients with psoriasis compared with matched referents.
authors.affiliation: Unit of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, SE-17177 Stockholm, Sweden. axel.svedbom@ki.se.
authors.forename: Axel
authors.initials: A
authors.lastname: Svedbom
authors.forename: Johan
authors.initials: J
authors.lastname: Dalén
authors.forename: Carla
authors.initials: C
authors.lastname: Mamolo
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Cappelleri
authors.forename: Lotus
authors.initials: L
authors.lastname: Mallbris
authors.forename: Ingemar F
authors.initials: IF
authors.lastname: Petersson
authors.forename: Mona
authors.initials: M
authors.lastname: Ståhle
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011565:Psoriasis / Q000175:diagnosis / Q000401:mortality*; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors