title: Proteomics analysis of bodily fluids in pancreatic cancer.
abstract: Proteomics study of pancreatic cancer using bodily fluids emphasizes biomarker discovery and clinical application, presenting unique prospect and challenges. Depending on the physiological nature of the bodily fluid and its proximity to pancreatic cancer, the proteomes of bodily fluids, such as pancreatic juice, pancreatic cyst fluid, blood, bile, and urine, can be substantially different in terms of protein constitution and the dynamic range of protein concentration. Thus, a comprehensive discovery and specific detection of cancer-associated proteins within these varied fluids is a complex task, requiring rigorous experiment design and a concerted approach. While major challenges still remain, fluid proteomics studies in pancreatic cancer to date have provided a wealth of information in revealing proteome alterations associated with pancreatic cancer in various bodily fluids.
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Teresa A
authors.initials: TA
authors.lastname: Brentnall
authors.affiliation: Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Ru
authors.initials: R
authors.lastname: Chen
mesh_terms: D001646:Bile / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D020420:Cyst Fluid / Q000378:metabolism; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D010181:Pancreatic Cyst / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000097:blood / Q000378:metabolism* / Q000652:urine; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
chemical_list: D020543:Proteome
keywords: Biomedicine; Bodily fluids; Mass spectrometry; Pancreatic cancer; Pancreatic ductal adenocarcinoma; Proteomics