title: Risk factors for progression in ADPKD.
abstract: OBJECTIVE
  Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. This article will describe the factors associated with both functional and structural evidence of disease progression. It will also review the results of recent clinical trials that have shown an impact on markers of disease progression.
  
  
  RESULTS
  A variety of prognostic factors have been described that relate to a decline in glomerular filtration rate or an increase in total cyst or kidney volumes. We now have clinical trials that show that glomerular filtration rate decline and kidney volume growth can be slowed in those with ADPKD.
  
  
  CONCLUSIONS
  With the emergence of potential disease-modifying therapies, factors that can accurately identify those who are most at risk for renal progression or ADPKD-related complications need to be identified and validated.
authors.affiliation: McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Ahsan
authors.initials: A
authors.lastname: Alam
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D018450:Disease Progression; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis* / Q000188:drug therapy*; D012307:Risk Factors
chemical_list: D015415:Biomarkers