title: Heterogeneously catalyzed direct C-H thiolation of heteroarenes.
abstract: The first general methodology for the direct thiolation of electron-rich heteroarenes was developed by employing Pd/Al2 O3 , a recoverable and commercially available heterogeneous catalyst, and CuCl2 . This method represents an operationally simple approach for the synthesis of these valuable compounds. Preliminary mechanistic studies indicate a heterogeneous catalytic system, in which both metals play a complementary role in the formation of the thiolated products.
authors.affiliation: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstraße 40, 48149 Münster (Germany).
authors.forename: Suhelen
authors.initials: S
authors.lastname: Vásquez-Céspedes
authors.forename: Angélique
authors.initials: A
authors.lastname: Ferry
authors.forename: Lisa
authors.initials: L
authors.lastname: Candish
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D006571:Heterocyclic Compounds; D013438:Sulfhydryl Compounds; D010165:Palladium; D003300:Copper; D000537:Aluminum Oxide; C029892:cupric chloride
keywords: CH functionalization; disulfides; heteroarenes; heterogeneous catalysis; thiolation