title: The role of vitamin D in the control of Leishmania infection.
abstract: Vitamin D has been described as an essential element for maintaining the homeostasis of mineral content in the body and bone architecture. However, our view of the physiological functions of this micronutrient has radically changed, owing to the vast number of properties, not calcium-related, mediated by its nuclear receptor. This receptor has been found in a variety of cells, including the immune cells, where many of the functions performed by vitamin D are related to inflammation. Although the effect of vitamin D has been widely studied in many diseases caused by viruses or bacteria, very little is known about its role in parasitic diseases, such as leishmaniasis, which is a vector-borne disease caused by different species of the intracellular parasite Leishmania spp. This disease occurs as a spectrum of different clinical syndromes, all of them characterized by a large amount of tissue damage, sometimes leading to necrosis. Owing to the involvement of vitamin D in inflammation and wound healing, its role in leishmaniasis must be relevant, and could be used as an adjuvant for the control of this parasitic disease, opening a possibility for a therapeutic application.
authors.affiliation: Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Dr. Balmis 148, Colonia Doctores, Cuauhtemoc, México D.F. 06720, México.
authors.forename: Espiridión
authors.initials: E
authors.lastname: Ramos-Martínez
authors.forename: Laila
authors.initials: L
authors.lastname: Gutierrez-Kobeh
authors.forename: Mónica Irais
authors.initials: MI
authors.lastname: Villaseñor-Cardoso
mesh_terms: D000818:Animals; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy* / Q000453:epidemiology* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D
keywords: 1,25(OH)2D3; cicatrisation; cytokines; immunoregulation; immunorégulation; inflammation; leishmaniasis; leishmaniose; wound healing