title: [Recognition mechanism of hepatitis C viral infection].
abstract: In the viral reproduction, hepatitis C virus(HCV) produces double-stranded RNA (dsRNA) as a replication intermediate. RIG-I(retinoic acid inducible protein I) recognizes the intracellular HCV dsRNA as a "non self" molecule, and triggers the induction of interferon (IFN)-β and then numerous IFN-stimulated genes(ISGs). On the other hand, one of toll-like receptors, TLR3 also recognizes the extracellular HCV dsRNA, and subsequently triggers the induction of IFN-β and ISGs. We recently reported class A scavenger receptor (MSR1) was required for TLR3-mediated recognition of the extracellular HCV dsRNA. In this review, we summarize current knowledge about RIG-I- and TLR3/MSR1-mediated recognition mechanisms of HCV infection.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Dansako
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kato
mesh_terms: D000818:Animals; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics / Q000502:physiology*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D012330:RNA, Double-Stranded / Q000502:physiology; D012367:RNA, Viral / Q000648:ultrastructure; D014779:Virus Replication / Q000502:physiology
chemical_list: D012330:RNA, Double-Stranded; D012367:RNA, Viral