title: Pharyngocutaneous fistula after salvage laryngectomy.
abstract: CONCLUSIONS
  Preoperative chemoradiotherapy (CRT) was associated with a significantly higher rate of pharyngocutaneous fistula (PCF).
  
  
  OBJECTIVE
  PCF is the most frequent complication following total laryngectomy. Although organ-preserving radiotherapy (RT) or CRT offer good locoregional control, many patients still require salvage laryngectomy. The aim of this study was to evaluate the factors that predispose patients to PCF, with a focus on preoperative RT, induction chemotherapy (ICT), and CRT.
  
  
  METHODS
  This was a retrospective case series; 151 patients who underwent TL were reviewed. Preoperative RT, ICT, CRT, and some surgical parameters were analyzed as potential risk factors.
  
  
  RESULTS
  The overall PCF rate was 13%. CRT was the only preoperative treatment that had a significant effect on PCF (35.3%, p = 0.004, odds ratio (OR) = 10.75). Surgery extended to the pharynx (p = 0.005, OR = 8.34) and vacuum drain duration (p = 0.012, OR = 5.16) were observed to be associated with PCF.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery.
authors.forename: Nilda
authors.initials: N
authors.lastname: Süslü
authors.forename: Rezarta Taga
authors.initials: RT
authors.lastname: Senirli
authors.forename: R Önder
authors.initials: RÖ
authors.lastname: Günaydın
authors.forename: Serdar
authors.initials: S
authors.lastname: Özer
authors.forename: Jale
authors.initials: J
authors.lastname: Karakaya
authors.forename: A Şefik
authors.initials: AŞ
authors.lastname: Hoşal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy / Q000009:adverse effects; D017577:Cutaneous Fistula / Q000209:etiology*; D016154:Digestive System Fistula / Q000209:etiology*; D005260:Female; D006801:Humans; D007825:Laryngectomy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010608:Pharyngeal Diseases / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D016879:Salvage Therapy
keywords: Total laryngectomy; chemoradiotherapy; radiotherapy