title: Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology--discrimination of normal human prostate tissues ex vivo.
abstract: Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p < 0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer.
authors.affiliation: Department of Engineering Sciences and Mathematics, Luleå University of Technology , Luleå , Sweden .
authors.forename: M
authors.initials: M
authors.lastname: Nyberg
authors.forename: V
authors.initials: V
authors.lastname: Jalkanen
authors.forename: K
authors.initials: K
authors.lastname: Ramser
authors.forename: B
authors.initials: B
authors.lastname: Ljungberg
authors.forename: A
authors.initials: A
authors.lastname: Bergh
authors.forename: O A
authors.initials: OA
authors.lastname: Lindahl
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013059:Spectrum Analysis, Raman / Q000295:instrumentation* / Q000379:methods
keywords: Prostate cancer; radical prostatectomy; raman spectroscopy; tactile resonance technology; tissue autofluorescence