title: The polymorphism (Gln261Arg) of 12-lipoxygenase and cancer risk: a meta-analysis.
abstract: BACKGROUND
  Many studies suggest that the Gln261Arg polymorphism in 12-lipoxygenase gene is assicated with cancer susceptibility, but the results are inconclusive. This meta-analysis aimed to investigate the overall association between the Gln261Arg polymorphism in 12-lipoxygenase gene and cancer risk.
  
  
  METHODS
  Literature search was performed in Pubmed, Embase and other databases for studies evaluating the association between the Gln261Arg polymorphism in 12-lipoxygenase gene and cancer risk. Data were extracted and statistical analysis was performed using STATA 12.0 software.
  
  
  RESULTS
  A total of eight publications involving 8,379 subjects were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and cancer susceptibility with an OR of 1.19 (95% CI: 1.09-1.31, P=0.000 for Gln/Gln vs. Arg/Gln + Arg/Arg). Subgroup analysis by ethnicity showed that the cancer risk associated with the Gln261Arg polymorphism in 12-lipoxygenase gene was significantly elevated among Asians (OR=1.21, 95% CI: 1.10-1.34, P=0.000 for Gln/Gln vs. Arg/Gln + Arg/Arg), but not among Caucasians. Subgroup analysis by cancer type suggested that the Gln261Arg polymorphism in 12-lipoxygenase gene is not a risk factor for colon cancer or rectal cancer.
  
  
  CONCLUSIONS
  This meta-analysis suggests that the Gln261Arg polymorphism in 12-lipoxygenase gene contributes to cancer susceptibility, specifically in Asian populations. More studies are needed to validate our findings.
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu 610041, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Shan
authors.affiliation: Radiation Physics Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University Chengdu 610041, Sichuan, China.
authors.forename: Konglong
authors.initials: K
authors.lastname: Shen
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Feng
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wan
authors.affiliation: Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Chengdu 610041, China.
authors.forename: Liangzhi
authors.initials: L
authors.lastname: Xu
keywords: 12-lipoxygenase; Cancer; meta-analysis; polymorphism