title: Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model.
abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease. The current standard treatment with glucocorticoids (GCs) leads to many adverse effects, and its effectiveness is questionable. Thus, it is critical and urgent to find new drug(s) for treatment of IPF. Baicalin (BAI) is an attractive candidate for this purpose. Herein, utilizing shotgun lipidomics, we revealed that IPF could lead to a lipid disorder of the liver in an animal model induced by bleomycin and confirmed through histopathological studies of the lung. Lipidomics further demonstrated that this disorder could virtually be corrected after treatment with BAI, but not with dexamethasone (DEX) (a commonly used GC for treatment of IPF). In contrast, the treatment with DEX did not improve IPF but led to tremendous alterations in hepatic lipidomes and accumulation of fat in the liver, which was very different from the lipid disorder induced by IPF. The underpinning mechanisms of the IPF-resultant lipid disorder and DEX-induced lipotoxicity as revealed by shotgun lipidomics were extensively discussed. Taken together, the current study showed that IPF could lead to hepatic lipid disorder, which can be treated with BAI, and demonstrated that lipidomics could be a powerful tool for drug screening.
authors.affiliation: College of Basic Medical Sciences, Zhejiang Chinese Medical University, 548 Bingwen Road, Hangzhou, Zhejiang, 310053, China.
authors.forename: Changfeng
authors.initials: C
authors.lastname: Hu
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Fan
authors.forename: Haichang
authors.initials: H
authors.lastname: Li
authors.forename: Chunyan
authors.initials: C
authors.lastname: Wang
authors.forename: Jida
authors.initials: J
authors.lastname: Zhang
authors.forename: Shuijuan
authors.initials: S
authors.lastname: Zhang
authors.forename: Xianlin
authors.initials: X
authors.lastname: Han
authors.forename: Chengping
authors.initials: C
authors.lastname: Wen
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology / Q000633:toxicity; D005234:Fatty Liver / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005419:Flavonoids / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology / Q000633:toxicity; D054990:Idiopathic Pulmonary Fibrosis / Q000150:complications / Q000188:drug therapy*; D008055:Lipids / Q000737:chemistry; D008107:Liver Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D005419:Flavonoids; D005938:Glucocorticoids; D008055:Lipids; C038044:baicalin; D003907:Dexamethasone