title: Antihyperlipidemic Activity of the Ethyl-acetate Fraction of Stereospermum Suaveolens in Streptozotocin-induced Diabetic Rats.
abstract: OBJECTIVE
  Dyslipidemia in diabetes mellitus is a significant risk factor for the development of cardiovascular complications. The aim of this study was to evaluate the effect of the ethyl-acetate fraction of an ethanolic extract from Streospermum suaveolens on lipid metabolism in streptozotocin (STZ)-induced diabetic rats.
  
  
  METHODS
  Diabetes was induced by intraperitonial injection of STZ (50 mg/kg). Diabetic rats were treated with an ethyl-acetate fraction orally at doses of 200 and 400 mg/kg daily for 14 days. On the 15(th) day, serum lipid profiles, such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were estimated in experimental rats. The atherogenic (AI) and the coronary risk (CRI) indices were also evaluated.
  
  
  RESULTS
  The ethyl-acetate fraction at doses of 200 and 400 mg/kg significantly (P< 0.001) and dose-dependently reduced serum cholesterol, triglycerides and LDL, but increased HDL towards near normal levels as compared to diabetic control rats. The fraction also significantly (P< 0.001) lowered the atherogenic index (AI) and coronary risk index (CAI) in a dose-dependent manner.
  
  
  CONCLUSIONS
  The present study demonstrated that the ethyl-acetate fraction of Stereospermum suaveolens exhibits a potent antihyperlipidemic activity in hyperglycemic rats and suggests that the plant may have therapeutic value in treating the diabetic complication of hyperlipidemia.
authors.affiliation: Department of Pharmacology, Al Shifa College of Pharmacy, Kerala, India.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Thirumalaisamy
authors.affiliation: Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathinagara, Karnataka, India.
authors.forename: Senthilkumar Gnanavadevel
authors.initials: SG
authors.lastname: Prabhakaran
authors.affiliation: Department of Pharmacology, Al Shifa College of Pharmacy, Kerala, India.
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Marimuthu
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Chatterjee
keywords: STZ-diabetic rats; Stereospermum suaveolens; antihyperlipidemic; atherogenic index; coronary risk index; ethyl acetate fraction