title: Nordihydroguiaretic acid attenuates skin tumorigenesis in Swiss albino mice with the condition of topical co-administration of an immunosuppressant.
abstract: Drug and chemically-induced immunosuppression has been implicated as a confounding factor for cancer development. Management of cancer in such situation is often a challenging task. We tested the efficacy of nordihydroguiaretic acid (NDGA) against immunosuppressant tacrolimus-induced augmentation of mouse skin tumorigenesis. It was observed that topical administration of tacrolimus significantly accelerated the tumor promotion events in dimethylbenz(a)anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted two-stage mouse skin carcinogenesis, which were accompanied by reduced CD4(+)/CD8(+) ratio of lymph nodes and serum IL-2 level. NDGA pre-treatment before each TPA application reduced the tumor incidence, its multiplicity and volume together with improvement in histopathological alterations and decrease in proliferating cell nuclear antigen (PCNA) labeling index (LI). However, NDGA had no significant influence on the immunosuppressive effect of tacrolimus. The present study demonstrates chemopreventive effect of NDGA in normal as well as in the condition of immunosuppression. Thus, NDGA has the potential to inhibit or delay the onset of tumor development during immunosuppressive regimen.
authors.affiliation: Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.
authors.forename: Shakilur
authors.initials: S
authors.lastname: Rahman
authors.affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 054, India.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Farooque
authors.affiliation: Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.
authors.forename: Sameya
authors.initials: S
authors.lastname: Anjum
authors.affiliation: Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.
authors.forename: Rizwan Ahmad
authors.initials: RA
authors.lastname: Ansari
authors.affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 054, India.
authors.forename: Jawahar S
authors.initials: JS
authors.lastname: Adhikari
authors.affiliation: Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Delhi 110 054, India.
authors.forename: Bilikere S
authors.initials: BS
authors.lastname: Dwarakanath
authors.affiliation: Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India. Electronic address: sraisuddin@jamiahamdard.ac.in.
authors.forename: Sheikh
authors.initials: S
authors.lastname: Raisuddin
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D063646:Carcinogenesis / Q000139:chemically induced / Q000187:drug effects / Q000473:pathology; D005260:Female; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D009637:Masoprocol / Q000627:therapeutic use*; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D016588:Anticarcinogenic Agents; D007166:Immunosuppressive Agents; D009637:Masoprocol; D016559:Tacrolimus
keywords: Chemoprevention; Immunosuppression; Nordihydroguaiaretic acid; Skin cancer; Tacrolimus