title: Highly efficient antibacterial surface grafted with a triclosan-decorated poly(N-hydroxyethylacrylamide) brush.
abstract: This work presented a highly efficient antibacterial Ti-surface which was grafted with poly(N-hydroxyethylacrylamide) (PHEAA) brush and further decorated with triclosan (TCS). The modified surfaces were characterized using contact angle measurements, X-ray photoelectron spectroscopy, and attenuated total reflectance Fourier transform infrared. The antibacterial performance of the modified surfaces was evaluated using the Streptococcus mutans and Actinomyces naeslundii attachment test. The Ti surface with PHEAA brush (Ti-PHEAA) was able to resist the adhesion of the bacteria, while the TCS-decorated Ti surface (Ti-TCS) showed the capability of killing the bacteria adhered on the surface. As we coupled the TCS to the PHEAA brush, the surface showed highly efficient antibacterial performance due to the combination of the resistance to the bacteria adhesion and its activity of killing bacteria.
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.|‡College of Chemistry and Chemical Engineering, Luoyang Normal University, Luoyang, Henan 471022, P. R. China.
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Wu
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tan
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Zhao-Wen
authors.initials: ZW
authors.lastname: Tang
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Mei-Yan
authors.initials: MY
authors.lastname: Yang
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Jian-Yun
authors.initials: JY
authors.lastname: Xiao
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Liu
authors.affiliation: †Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, Hubei 430072, P. R. China.
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry* / Q000494:pharmacology; D000190:Actinomyces / Q000187:drug effects / Q000502:physiology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects / Q000502:physiology; D013499:Surface Properties; D014260:Triclosan / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; C074962:poly-N-(2-hydroxyethyl)acrylamide; D014260:Triclosan
keywords: antibacterial surface; poly(N-hydroxyethylacrylamide); polymer brush; resistance to bacterial adhesion; surface grafting; triclosan