title: [Changes of plasma cardiotrophin-1 levels in neonates with myocardial ischemic injury].
abstract: OBJECTIVE
  To study the changes and significance of plasma cardiotrophin-1 (CT-1) in neonates with hypoxic-ischemic encephalopathy (HIE) complicated by myocardial ischemic injury.
  
  
  METHODS
  Forty-five neonates with HIE (15 mild cases, 24 moderate cases and 6 severe cases) were enrolled and divided into two subgroups based on the presence of myocardial injury (n=19) and not (n=26). Twenty healthy neonates were used as the control group. Plasma CT-1 levels were measured using double-antibody sandwich enzyme immunoassay method. Serum creatinine kinase MB (CK-MB) and cardiac troponin I (CTnI ) levels were also measured.
  
  
  RESULTS
  Plasma CT-1 levels in the mild HIE (169±20 pg/mL) and moderate/severe HIE subgroups (287±44 pg/mL) were significantly higher than those in the control group (30±8 pg/mL), and plasma CT-1 levels were associated with the severity of HIE (P<0.01). Plasma CT-1 levels were positively correlated with serum CK-MB and CTnI levels in neonates with HIE in the acute phase (r=0.565 and 0.621 respectively; P<0.01). Plasma CT-1 levels in neonates with myocardial injury were significantly higher than those without myocardial injury (249 ±35 pg/mL vs 177±26 pg/mL; P<0.01). Plasma CT-1 levels were significantly reduced in neonates with myocardial injury in the convalescent phase (157±19 pg/mL) compared with those in the acute phase (249±35 pg/mL; P<0.01).
  
  
  CONCLUSIONS
  Detection of plasma CT-1 levels may be useful in the diagnosis of myocardial ischemic injury and the severity evaluation of HIE.
authors.affiliation: Department of Pediatrics, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China. jianglianerke@163.com.
authors.forename: Yu-Qiao
authors.initials: YQ
authors.lastname: Diao
authors.forename: Lian
authors.initials: L
authors.lastname: Jiang
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Qu
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.forename: Qin
authors.initials: Q
authors.lastname: Shao
mesh_terms: D052279:Creatine Kinase, MB Form / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood*; D019210:Troponin I / Q000097:blood
chemical_list: D016207:Cytokines; D019210:Troponin I; C092073:cardiotrophin 1; D052279:Creatine Kinase, MB Form