title: Dienogest. A possible conservative approach in bladder endometriosis. Results of a pilot study.
abstract: Deep endometriosis involvement of the bladder is uncommon but it is symptomatic in most of the cases. Although laparoscopic excision is very effective, some patients with no pregnancy desire require a medical approach. We performed a pilot study on the effect of a new progestin dienogest on bladder endometriosis. Six patients were treated for 12 months with dienogest 2 mg/daily. Pain, urinary symptoms, quality of life, nodule volume and side effects were recorded. During treatment, symptoms improved very quickly and the nodules exhibit a remarkable reduction in size. Dienogest may be an alternative approach to bladder endometriosis.
authors.affiliation: Division of Gynecology and Obstetrics, Department of Surgical Sciences, University of Cagliari , Monserrato , Italy .
authors.forename: Stefano
authors.initials: S
authors.lastname: Angioni
authors.forename: Luigi
authors.initials: L
authors.lastname: Nappi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pontis
authors.forename: Federica
authors.initials: F
authors.lastname: Sedda
authors.forename: Stefano
authors.initials: S
authors.lastname: Luisi
authors.forename: Valerio
authors.initials: V
authors.lastname: Mais
authors.forename: Gian Benedetto
authors.initials: GB
authors.lastname: Melis
mesh_terms: D000328:Adult; D015331:Cohort Studies; D053159:Dysuria; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006417:Hematuria; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010865:Pilot Projects; D011788:Quality of Life; D016896:Treatment Outcome; D014463:Ultrasonography; D001745:Urinary Bladder Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D006727:Hormone Antagonists; C023635:dienogest; D009277:Nandrolone
keywords: Deep endometriosis; dienogest; dysuria; pelvic pain