title: A high performance nonenzymatic electrochemical glucose sensor based on polyvinylpyrrolidone-graphene nanosheets-nickel nanoparticles-chitosan nanocomposite.
abstract: In this report, a new nanocomposite was successfully synthesized by chemical deposition of nickel nanoparticles (NiNPs) on polyvinylpyrrolidone (PVP) stabilized graphene nanosheets (GNs) with chitosan (CS) as the protective coating. The as obtained nanocomposite (PVP-GNs-NiNPs-CS) was characterized by X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Benefiting from the synergistic effect of GNs (large surface area and high conductivity), NiNPs (high electrocatalytic activity towards the glucose oxidation) and CS (good film-forming and antifouling ability), a nonenzymatic electrochemical glucose sensor was established. The nanocomposite displays greatly enhanced electrocatalytic activity towards the glucose oxidation in NaOH solution. The PVP-GNs-NiNPs-CS based electrochemical glucose sensor demonstrates good sensitivity, wide linear range (0.1 μM-0.5 mM), outstanding detection limit (30 nM), attractive selectivity, good reproducibility, high stability as well as prominent feasibility for the real sample analysis. The proposed experiment might open up a new possibility for widespread use of non-enzymatic sensors for monitoring blood glucose owing to its advantages of low cost, simple preparation and excellent properties for glucose detection.
authors.affiliation: Institute of Environmental Science, Shanxi University, Taiyuan 030006, China.
authors.forename: Zhiguang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Institute of Environmental Science, Shanxi University, Taiyuan 030006, China. Electronic address: guoyj@sxu.edu.cn.
authors.forename: Yujing
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Institute of Environmental Science, Shanxi University, Taiyuan 030006, China. Electronic address: dc@sxu.edu.cn.
authors.forename: Chuan
authors.initials: C
authors.lastname: Dong
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004563:Electrochemistry / Q000191:economics / Q000295:instrumentation*; D004566:Electrodes; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D015203:Reproducibility of Results
chemical_list: D006108:Graphite; D009532:Nickel; D048271:Chitosan; D011205:Povidone; D005947:Glucose
keywords: Chitosan; Graphene nanosheets; Nickel nanoparticles; Nonenzymatic electrochemical glucose sensor; Polyvinylpyrrolidone