title: microRNA-200b as a Switch for Inducible Adult Angiogenesis.
abstract: CONCLUSIONS
  Angiogenesis is the process by which new blood vessels develop from a pre-existing vascular system. It is required for physiological processes such as developmental biology and wound healing. Angiogenesis also plays a crucial role in pathological conditions such as tumor progression. The underlying importance of angiogenesis necessitates a highly regulated process.
  
  
  BACKGROUND
  Recent works have demonstrated that the process of angiogenesis is regulated by small noncoding RNA molecules called microRNAs (miRs). These miRs, collectively referred to as angiomiRs, have been reported to have a profound effect on the process of angiogenesis by acting as either pro-angiogenic or anti-angiogenic regulators.
  
  
  RESULTS
  In this review, we will discuss the role of miR-200b as a regulator of angiogenesis. Once the process of angiogenesis is complete, anti-angiogenic miR-200b has been reported to provide necessary braking. Downregulation of miR-200b has been reported across various tumor types, as deregulated angiogenesis is necessary for tumor development. Transient downregulation of miR-200b in wounds drives wound angiogenesis.
  
  
  CONCLUSIONS
  New insights and understanding of the molecular mechanism of regulation of angiogenesis by miR-200b has opened new avenues of possible therapeutic interventions to treat angiogenesis-related patho-physiological conditions. Antioxid. Redox Signal. 22, 1257-1272.
authors.affiliation: Center for Regenerative Medicine and Cell Based Therapies, Davis Heart and Lung Research Institute, Ohio State University , Columbus, Ohio.
authors.forename: Mithun
authors.initials: M
authors.lastname: Sinha
authors.forename: Subhadip
authors.initials: S
authors.lastname: Ghatak
authors.forename: Sashwati
authors.initials: S
authors.lastname: Roy
authors.forename: Chandan K
authors.initials: CK
authors.lastname: Sen
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic
chemical_list: D043925:Angiogenesis Inducing Agents; C533896:MIRN200 microRNA, human; C555600:MIRN200 microRNA, rat; D035683:MicroRNAs