title: Cellular responses evoked by different surface characteristics of intraosseous titanium implants.
abstract: The properties of biomaterials, including their surface microstructural topography and their surface chemistry or surface energy/wettability, affect cellular responses such as cell adhesion, proliferation, and migration. The nanotopography of moderately rough implant surfaces enhances the production of biological mediators in the peri-implant microenvironment with consequent recruitment of differentiating osteogenic cells to the implant surface and stimulates osteogenic maturation. Implant surfaces with moderately rough topography and with high surface energy promote osteogenesis, increase the ratio of bone-to-implant contact, and increase the bonding strength of the bone to the implant at the interface. Certain features of implant surface chemistry are also important in enhancing peri-implant bone wound healing. It is the purpose of this paper to review some of the more important features of titanium implant surfaces which have an impact on osseointegration.
authors.affiliation: Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
authors.forename: Liviu
authors.initials: L
authors.lastname: Feller
authors.affiliation: Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Jadwat
authors.affiliation: Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
authors.forename: Razia A G
authors.initials: RA
authors.lastname: Khammissa
authors.affiliation: Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
authors.forename: Robin
authors.initials: R
authors.lastname: Meyerov
authors.affiliation: Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, 32000 Haifa, Israel.
authors.forename: Israel
authors.identifier: 0000-0003-1058-7135
authors.initials: I
authors.lastname: Schechter
authors.affiliation: Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
authors.forename: Johan
authors.initials: J
authors.lastname: Lemmer
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects*; D019736:Prostheses and Implants; D013499:Surface Properties; D014025:Titanium / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D014025:Titanium