title: Improvement of fatigue in multiple sclerosis by physical exercise is associated to modulation of systemic interferon response.
abstract: Mechanisms underlying multiple sclerosis (MS) fatigue and the causes of the beneficial effect of exercise on this symptom are not clarified. Our aim was to evaluate gene expression profiles in MS patients who improved their fatigue status after an exercise program and to compare them with healthy controls (HC). Gene expression in whole blood was profiled at baseline in 7 HC and also in 7 fatigued-MS patients. Patients underwent an exercise program for 6 months, and their fatigue status and gene expression profiles were again analyzed. MS patients showed a significant activation of genes participating in the systemic interferon response in comparison with HC that disappeared at the end of the program. Our results provide a biological basis for the observed benefit of exercise in MS.
authors.affiliation: Servicio de Neurología, Hospital Clínico de Valladolid, Spain. Electronic address: pamuca84@hotmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Mulero
authors.affiliation: Unidad de Apoyo a la Investigación, Hospital Clínico de Valladolid, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Almansa
authors.affiliation: Servicio de Neurología, Hospital Clínico de Valladolid, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Neri
authors.affiliation: Unidad de Apoyo a la Investigación, Hospital Clínico de Valladolid, Spain.
authors.forename: Jesús Francisco
authors.initials: JF
authors.lastname: Bermejo-Martin
authors.affiliation: Servicio de Medicina Física y Rehabilitación, Hospital Clínico de Valladolid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Archanco
authors.affiliation: Servicio de Neurología, Hospital Clínico de Valladolid, Spain.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Arenillas
authors.affiliation: Servicio de Neurología, Hospital Clínico de Valladolid, Spain.
authors.forename: Nieves
authors.initials: N
authors.lastname: Téllez
mesh_terms: D000328:Adult; D015444:Exercise; D005221:Fatigue / Q000209:etiology* / Q000534:rehabilitation*; D005260:Female; D020869:Gene Expression Profiling; D006304:Health Status; D006801:Humans; D007372:Interferons / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D020411:Oligonucleotide Array Sequence Analysis; D025341:Principal Component Analysis; D016896:Treatment Outcome
chemical_list: D007372:Interferons
keywords: Fatigue; Interferon; Multiple sclerosis; Physical activity