title: Mucositis: pathobiology and management.
abstract: OBJECTIVE
  Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis.
  
  
  RESULTS
  Prevalence and incidence data for mucositis are inconsistent and often underreported. The pathogenesis of mucositis encompasses a sequence of biological events possibly influenced by the oral microbiome and environment. Despite its frequency and severity, there is currently no effective treatment available for the majority of patients at risk. However, with the better understanding of the pathogenesis of mucositis a number of new drugs and biological agents are under investigation. Genome-wide risk prediction tools will allow the identification of patients at risk of developing mucositis.
  
  
  CONCLUSIONS
  Oral mucositis is a common complication of cancer treatment that may negatively impact the patient's cancer treatment outcome. Despite its frequency and consequences, the lack of effective interventions has frustrated patients and caregivers. Fortunately, a broad range of mechanistically targeted compounds are being developed.
authors.affiliation: Division of Oral Medicine and Dentistry, Brigham and Women's Hospital Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Villa
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Sonis
mesh_terms: D004999:Amifostine / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D051523:Fibroblast Growth Factor 7 / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D056990:Post-Exposure Prophylaxis; D011788:Quality of Life; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects*; D012307:Risk Factors; D013280:Stomatitis / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D011837:Radiation-Protective Agents; D051523:Fibroblast Growth Factor 7; D004999:Amifostine