title: Long-term outcomes of intravitreal injection of bevacizumab for choroidal neovascularization associated with choroidal osteoma.
abstract: OBJECTIVE
  To describe the outcomes of intravitreal injections of bevacizumab for choroidal neovascularization (CNV) associated with choroidal osteoma.
  
  
  METHODS
  Retrospective consecutive case series. Three eyes of three patients were studied. All patients were treated with intravitreal injections of bevacizumab for CNV associated with choroidal osteoma. Best-corrected visual acuity, central foveal thickness, tumor thickness on spectral domain optical coherence tomography, and subretinal pigmentation around the CNV were evaluated.
  
  
  RESULTS
  The mean number of intravitreal injections of bevacizumab was 2.0 (range 1-3). The mean follow-up time was 56.0 months (range 25-99 months). The mean LogMAR visual acuity worsened from 0.1 to 0.6. LogMAR visual acuity loss of 0.7 or worse occurred in two of three eyes. CNV was located in the subfoveal area in two eyes, and CNV was located in the juxtafoveal area in one eye. The mean central foveal thickness decreased from 407 μm to 251 μm. The mean tumor thickness decreased from 709 μm to 608 μm. All eyes had subretinal pigmentation around the CNV.
  
  
  CONCLUSIONS
  Intravitreal injections of bevacizumab for subfoveal CNV associated with decalcified choroidal osteoma resulted in poor visual acuity.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Yoshikawa
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Takahashi
keywords: Avastin; bevacizumab; choroidal neovascularization; choroidal osteoma; vascular endothelial growth factor