title: Cutaneous metastases from esophageal adenocarcinoma.
abstract: The aim of this study is to present 2 rare cases of cutaneous metastases originated from adenocarcinoma of the gastro-esophageal junction, thus, underline the need for early diagnosis and possible treatment of suspicious skin lesions among patients with esophageal malignancy. Metastatic cancer to the skin originated from internal malignancies, mostly lung cancer, breast cancer, and colorectal cancer, constitute 0.5 to 9% of all metastatic cancers. (5, 8, 15) Skin metastases, mainly from squamous cell carcinomas of the esophagus, are rarely reported. Cutaneous metastasis is a finding indicating progressiveness of the disease. (17) More precisely, median survival is estimated approximately 4.7 months. (2, 14) This study is a retrospective review of 2 cases of patients with adenocarcinoma of the esophagus and a review of the literature. Two patients aged 60 and 32 years old, respectively, underwent esophagectomy. Both pathologic reports disclosed adenocarcinoma of the gastro-esophageal junction staged T3 N2 M0 (stage IIIB). During follow-up time, the 2 patients were diagnosed with cutaneous metastases originated from the primary esophageal tumor 11 and 4 months after surgery, respectively. The first patient is alive 37 months after diagnosis, while the second one died 16 months after surgery. Cutaneous metastasis caused by esophageal adenocarcinoma is possible. Therefore, follow-up of patients who were diagnosed with esophageal malignancy and underwent esophagectomy is mandatory in order to reveal early surgical stages.
authors.affiliation: 1 First Propaedeutic Department of Surgery, Hippocration Hospital, University of Athens, Athens, Greece.
authors.forename: Stamatina
authors.initials: S
authors.lastname: Triantafyllou
authors.forename: Doulami
authors.initials: D
authors.lastname: Georgia
authors.forename: Vrakopoulou
authors.initials: V
authors.lastname: Gavriella-Zoi
authors.forename: Mpistarakis
authors.initials: M
authors.lastname: Dimitrios
authors.forename: Katsaragakis
authors.initials: K
authors.lastname: Stulianos
authors.forename: Liakakos
authors.initials: L
authors.lastname: Theodoros
authors.forename: Zografos
authors.initials: Z
authors.lastname: Georgios
authors.forename: Theodorou
authors.initials: T
authors.lastname: Dimitrios
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000556:secondary*; D000328:Adult; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary*
keywords: Adenocarcinoma; Classification description: general surgery; Cutaneous; Esophagus; Metastasis; Oncologic surgery; Upper gastrointestinal surgery