title: Infarction of the corpus callosum: a retrospective clinical investigation.
abstract: OBJECTIVE
  The aim of this study was to investigate patients with ischemic infarctions in the territory of the corpus callosum to advance our understanding of this rare stroke subtype by providing comprehensive descriptive and epidemiological data.
  
  
  METHODS
  From January 1, 2010 to June 30, 2014, all cases of acute ischemic stroke diagnosed by clinical manifestation and diffusion weighted imaging in Dalian Municipal Central Hospital were investigated. The patients presenting with corpus callosum infarctions were selected and further allocated into genu and/or body and splenium infarction groups. Proportion, lesion patterns, clinical features, risk factors and etiology of corpus callosum infarction were analyzed.
  
  
  RESULTS
  Out of 1,629 cases, 59 patients (3.6%) with corpus callosum infarctions were identified by diffusion weighted imaging, including 7 patients who had ischemic lesions restricted to the corpus callosum territory. Thirty six patients had lesions in the splenium (61.0%). Corpus callosum infarction patients suffered from a broad spectrum of symptoms including weakness and/or numbness of the limbs, clumsy speech, and vertigo, which could not be explained by lesions in corpus callosum. A classical callosal disconnection syndrome was found in 2 out of all patients with corpus callosum infarctions. Statistical differences in the risk factor and infarct pattern between the genu and/or body group and splenium group were revealed.
  
  
  CONCLUSIONS
  Corpus callosum infarction and the callosal disconnection syndrome were generally rare. The most susceptible location of ischemic corpus callosum lesion was the splenium. Splenium infarctions were often associated with bilateral cerebral hemisphere involvement (46.2%). The genu and/or body infarctions were associated with atherosclerosis. The most common cause of corpus callosum infarction probably was embolism.
authors.affiliation: Neurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.affiliation: Neurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Sun
authors.affiliation: Neurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
authors.forename: Yu-meng
authors.initials: YM
authors.lastname: Bai
authors.affiliation: Pathology Department, the Second Hospital of Dalian Medical University, 116027 Dalian, China.
authors.forename: Hua-min
authors.initials: HM
authors.lastname: Qin
authors.affiliation: Department of Clinical Epidemiology and Center of Evidence Based Medicine, the First Hospital of China Medical University, 110001 Shenyang, China.
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Wu
authors.affiliation: Radiology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Neurology Department, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Jolkkonen
authors.affiliation: Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany; Translational Centre for Regenerative Medicine, 04103 Leipzig, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Boltze
authors.affiliation: Neurology Department, Dalian Municipal Central Hospital affiliated to Dalian Medical University, 116033 Dalian, China.
authors.forename: Su-ping
authors.initials: SP
authors.lastname: Wang
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D003337:Corpus Callosum / Q000473:pathology* / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors