title: Genomic characterization of endometrial stromal sarcomas with array comparative genomic hybridization.
abstract: BACKGROUND
  The endometrial stromal sarcoma (ESS) is a very rare uterine sarcoma, counting for 1-3% of all gynecologic malignancies. ESS represents 0.2-8% of all uterine malignant tumors and accounts for about 10% of all uterine sarcomas. With regard to chromosomal aberrations, very little is known about benign and malignant endometrial stromal tumors.
  
  
  METHODS
  30 tumors, consisting of 4 cases of benign endometrial stromal nodule (ESN), 22 cases of low-grade ESS and 4 cases of undifferentiated endometrial sarcoma (UES), were analyzed by array-comparative genomic hybridization (aCGH).
  
  
  RESULTS
  ESN did not show many copy number changes (CNCs) by aCGH. Frequent losses could be identified on chromosomes 7p and 19, and gains on chromosomes 1q, 6p and 8q. Low-grade ESS presented as a very heterogeneous group. 90% (20/22) of cases displayed aberrations. Most frequent changes were losses on chromosomes 7 and 22, and gains on chromosome 1q or 11. UES showed a high number of chromosomal aberrations and on every chromosome CNCs were detected. Most frequent changes were losses on chromosomes 1q, 2q (3/4, 75%) and 13, and gains on chromosomes 1q and 17p.
  
  
  CONCLUSIONS
  Our data shows an increasing number of CNCs from ESN to low-grade ESS and to UES. However, the chromosomal aberrations differ considerably between the investigated ESN-, low-grade ESS- and UES cases and thus, a linear tumor progression seems to be unlikely.
authors.affiliation: Institute of Human Genetics, Medical University of Graz, Harrachgasse 21/8, A-8010 Graz, Austria.
authors.forename: Karin
authors.initials: K
authors.lastname: Flicker
authors.affiliation: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. Electronic address: elisabeth.smolle@stud.medunigraz.at.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Smolle
authors.affiliation: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. Electronic address: johannes.haybaeck@medunigraz.at.
authors.forename: Johannes
authors.initials: J
authors.lastname: Haybaeck
authors.affiliation: Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria; Institute of Pathology, Hospital of the Sisters of Charity Linz, Linz, Austria.
authors.forename: Farid
authors.initials: F
authors.lastname: Moinfar
mesh_terms: D002875:Chromosomes / Q000235:genetics; D055028:Comparative Genomic Hybridization; D056915:DNA Copy Number Variations; D036821:Endometrial Stromal Tumors / Q000235:genetics* / Q000473:pathology; D005260:Female; D015894:Genome, Human; D006801:Humans; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology
keywords: Array CGH; Endometrial stromal nodule; Endometrial stromal sarcoma