title: Effects of electrode position on spatiotemporal auditory nerve fiber responses: a 3D computational model study.
abstract: A cochlear implant (CI) is an auditory prosthesis that enables hearing by providing electrical stimuli through an electrode array. It has been previously established that the electrode position can influence CI performance. Thus, electrode position should be considered in order to achieve better CI results. This paper describes how the electrode position influences the auditory nerve fiber (ANF) response to either a single pulse or low- (250 pulses/s) and high-rate (5,000 pulses/s) pulse-trains using a computational model. The field potential in the cochlea was calculated using a three-dimensional finite-element model, and the ANF response was simulated using a biophysical ANF model. The effects were evaluated in terms of the dynamic range, stochasticity, and spike excitation pattern. The relative spread, threshold, jitter, and initiated node were analyzed for single-pulse response; and the dynamic range, threshold, initiated node, and interspike interval were analyzed for pulse-train stimuli responses. Electrode position was found to significantly affect the spatiotemporal pattern of the ANF response, and this effect was significantly dependent on the stimulus rate. We believe that these modeling results can provide guidance regarding perimodiolar and lateral insertion of CIs in clinical settings and help understand CI performance.
authors.affiliation: School of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Soojin
authors.identifier: 0000-0002-5100-1957
authors.initials: S
authors.lastname: Kang
authors.affiliation: School of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Tanmoy
authors.identifier: 0000-0002-3421-2410
authors.initials: T
authors.lastname: Chwodhury
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 330-714, Republic of Korea.
authors.forename: Il Joon
authors.identifier: 0000-0002-3613-0734
authors.initials: IJ
authors.lastname: Moon
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University, Seoul 330-714, Republic of Korea.
authors.forename: Sung Hwa
authors.identifier: 0000-0003-0862-3483
authors.initials: SH
authors.lastname: Hong
authors.affiliation: School of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Hyejin
authors.identifier: 0000-0002-5635-7266
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Audiology and Speech Pathology, University of Tennessee Health Science Center, Knoxville, TN 37996, USA.
authors.forename: Jong Ho
authors.identifier: 0000-0001-6176-1442
authors.initials: JH
authors.lastname: Won
authors.affiliation: School of Electrical Engineering, Biomedical Engineering, University of Ulsan, Ulsan 680-749, Republic of Korea.
authors.forename: Jihwan
authors.identifier: 0000-0003-2227-5948
authors.initials: J
authors.lastname: Woo
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000465:Algorithms; D003051:Cochlea / Q000502:physiology; D003054:Cochlear Implants; D003056:Cochlear Nerve / Q000473:pathology*; D003198:Computer Simulation; D004558:Electric Stimulation; D004566:Electrodes; D020342:Finite Element Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008564:Membrane Potentials; D015233:Models, Statistical; D009412:Nerve Fibers; D013269:Stochastic Processes