title: [Clinical study on 137 cases of unrelated single unit umbilical cord blood hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To evaluate relevant prognostic factors of unrelated single unit umbilical cord blood hematopoietic stem cell transplantation (sUCBT), and to explore the correlation between cryopreservation time of cord blood and cell viability and outcome of sUCBT.
  
  
  METHODS
  Retrospective analysis of 137 patients undergoing sUCBT with cord blood provided by Shanghai Cord Blood Bank from Mar. 15, 2007 to Dec. 26, 2013 were performed in this study. The mean cryopreservation time of 137 units cord blood was 698(96-1968) days, with mean cell viability of 87.4% after thawing.
  
  
  RESULTS
  No statistical difference on cell viability, hematopoietic reconstitution, graft failure, acute graft versus host disease (GVHD) and overall survival (OS) was found between patients transfused with cord blood preserved below and above 2 years. The 5-year OS of patients transfused with cord blood preserved below and above 2 years were 55.6% and 67.9%, respectively (P=0.124). OS of the UCBT at 2011 and before, and after 2011 was 48.7% and 79.6%, respectively (P=0.001). Age above 16-year-old (RR=2.830, P=0.027) and UCBT at 2011 and before (RR=0.203, P<0.001) were two risk factors of treatment related mortality.
  
  
  CONCLUSIONS
  Outcome of sUCBT in China had significant improvement in recent 2 years. Cryopreservation time of cord blood had no statistical correlation to cell viability after thawing and clinical outcome.
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Huanying
authors.initials: H
authors.lastname: Jin
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Yinting
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Xiayan
authors.initials: X
authors.lastname: Shao
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Jingsi
authors.initials: J
authors.lastname: Kong
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Wenhao
authors.initials: W
authors.lastname: Huang
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hong
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Li
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Shanghai Cord Blood Bank, Shanghai Stem Cell Technology Co., LTD., Shanghai 200051, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
mesh_terms: D002470:Cell Survival; D002681:China; D036101:Cord Blood Stem Cell Transplantation; D005312:Fetal Blood; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D012189:Retrospective Studies