title: Fermented green tea extract alleviates obesity and related complications and alters gut microbiota composition in diet-induced obese mice.
abstract: Obesity is caused by an imbalance between caloric intake and energy expenditure and accumulation of excess lipids in adipose tissues. Recent studies have demonstrated that green tea and its processed products (e.g., oolong and black tea) are introduced to exert beneficial effects on lipid metabolism. Here, we propose that fermented green tea (FGT) extract, as a novel processed green tea, exhibits antiobesity effects. FGT reduced body weight gain and fat mass without modifying food intake. mRNA expression levels of lipogenic and inflammatory genes were downregulated in white adipose tissue of FGT-administered mice. FGT treatment alleviated glucose intolerance and fatty liver symptoms, common complications of obesity. Notably, FGT restored the changes in gut microbiota composition (e.g., the Firmicutes/Bacteroidetes and Bacteroides/Prevotella ratios), which is reported to be closely related with the development of obesity and insulin resistance, induced by high-fat diets. Collectively, FGT improves obesity and its associated symptoms and modulates composition of gut microbiota; thus, it could be used as a novel dietary component to control obesity and related symptoms.
authors.affiliation: 1 Department of Food Bioscience & Technology, College of Life Sciences & Biotechnology, Korea University , Seoul, Korea.
authors.forename: Dae-Bang
authors.initials: DB
authors.lastname: Seo
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Jeong
authors.forename: Donghyun
authors.initials: D
authors.lastname: Cho
authors.forename: Bum Jin
authors.initials: BJ
authors.lastname: Lee
authors.forename: Ji Hae
authors.initials: JH
authors.lastname: Lee
authors.forename: Jae Young
authors.initials: JY
authors.lastname: Choi
authors.forename: Il-Hong
authors.initials: IH
authors.lastname: Bae
authors.forename: Sung-Joon
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D028241:Camellia sinensis / Q000737:chemistry*; D059305:Diet, High-Fat / Q000009:adverse effects; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts
keywords: fatty liver; green tea; health functional food; insulin resistance; obesity