title: Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor.
abstract: A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Mairead
authors.initials: M
authors.lastname: Reidy
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Ciaran
authors.initials: C
authors.lastname: O'Reilly
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Dilip V
authors.initials: DV
authors.lastname: Jarikote
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Arvind
authors.initials: A
authors.lastname: Negi
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Afshin
authors.initials: A
authors.lastname: Samali
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Eva
authors.initials: E
authors.lastname: Szegezdi
authors.affiliation: †School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Paul V
authors.initials: PV
authors.lastname: Murphy