title: Prevalence of hypertension after living-donor liver transplantation: a prospective study.
abstract: BACKGROUND
  Hypertension is common among patients who have undergone liver transplantation and is a major contributor to cardiovascular events. Few studies have studied the risk factors associated with post-liver transplantation (LT) hypertension. This prospective study assessed the prevalence of post-LT hypertension and associated preoperative risk factors.
  
  
  METHODS
  From May 2008 to December 2009, 79 normotensive adult patients (≥ 18 years old) who underwent living-donor LT with a median follow up of 4.79 ± 0.88 years were enrolled. Patients' pre-LT demographics, clinical data, pre-LT diabetes, and immunosuppressive agents used after LT were studied for their association with post-LT hypertension.
  
  
  RESULTS
  The prevalence of post-LT hypertension was 49.4%. The independent risk factors for post-living-donor LT hypertension were pre-LT systolic blood pressure (SBP; odds ratio [OR], 1.04; 95% confidence interval [CI], 1.00-1.09; P = .039) and post-LT administration of mammalian target of rapamycin (mTOR) inhibitors (OR, 4.08; 95% CI, 1.40-11.94; P = .010). Pre-LT diabetes had a negative predictive value (OR, 0.15; 95% CI, 0.03-0.74; P = .019). Neither age, male sex, smoking, pre-LT serum cholesterol and triglyceride levels, tacrolimus, nor glucocorticoid was associated with post-LT hypertension.
  
  
  CONCLUSIONS
  The prevalence of hypertension is high after LT. Higher pre-LT SBP and post-LT mTOR inhibitor administration predispose patients to post-LT hypertension.
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
authors.forename: M-S
authors.initials: MS
authors.lastname: Tong
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
authors.forename: H-T
authors.initials: HT
authors.lastname: Chai
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
authors.forename: W-H
authors.initials: WH
authors.lastname: Liu
authors.affiliation: Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
authors.forename: C-L
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
authors.forename: M
authors.initials: M
authors.lastname: Fu
authors.affiliation: Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
authors.forename: Y-H
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China; Liver Transplantation Program, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China.
authors.forename: C-C
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China. Electronic address: syming99@gmail.com.
authors.forename: S-M
authors.initials: SM
authors.lastname: Chen
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan, Republic of China; Chang Gung University College of Medicine, Kaohsiung City, Taiwan, Republic of China.
authors.forename: C-L
authors.initials: CL
authors.lastname: Hang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011183:Postoperative Complications / Q000453:epidemiology; D057234:Preoperative Period; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult