title: [Fluorescence in-situ hybridization as a diagnostic tool for cutaneous melanoma].
abstract: OBJECTIVE
  To explore the utility of fluorescence in situ hybridization as a diagnostic tool for cutaneous melanoma.
  
  
  METHODS
  Twenty cutaneous melanomas and 20 cutaneous nevi from pathology files were selected and analyzed by Vysis melanoma FISH probe kit targeting 3 loci on chromosome 6 (MYB, CEP6 and RREB1) and 1 locus on 11q (CCND1) and data were interpreted based on the Abbott criteria provided by the kit.
  
  
  RESULTS
  Informative FISH results were obtained in 16 melanomas and 18 nevi. Chromosomal aberrations were detected in 12 of the 16 melanomas and only 1 of 18 nevi.
  
  
  CONCLUSIONS
  FISH is a useful diagnostic tool and able to distinguish cutaneous nevus from melanoma with good sensitivity and specificity.
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China. E-mail: liujianying@bjmu.edu.cn.
authors.forename: Jianying
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Jiangfeng
authors.initials: J
authors.lastname: You
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University,Beijing 100191, China.
authors.forename: Songlin
authors.initials: S
authors.lastname: Liao
mesh_terms: D002869:Chromosome Aberrations; D019938:Cyclin D1 / Q000235:genetics; D003937:Diagnosis, Differential; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008545:Melanoma / Q000175:diagnosis* / Q000235:genetics; D009506:Nevus / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics; D000096142:Cutaneous Malignant Melanoma
chemical_list: D019938:Cyclin D1