title: Polarization Effects in Optical Coherence Tomography of Various Biological Tissues.
abstract: Polarization sensitive optical coherence tomography (PS-OCT) was used to obtain spatially resolvedex vivoimages of polarization changes in skeletal muscle, bone, skin and brain. Through coherent detection of two orthogonal polarization states of the signal formed by interference of light reflected from the biological sample and a mirror in the reference arm of a Michelson interferometer, the depth resolved change in polarization was measured. Inasmuch as any fibrous structure will influence the polarization of light, PS-OCT is a potentially powerful technique investigating tissue structural properties. In addition, the effects of single polarization state detection on OCT image formation is demonstrated.
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: Johannes F
authors.initials: JF
authors.lastname: de Boer
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: Shyam M
authors.initials: SM
authors.lastname: Srinivas
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: B Hyle
authors.initials: BH
authors.lastname: Park
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: Tuan H
authors.initials: TH
authors.lastname: Pham
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Biomedical Engineering Program, University of Texas at Austin, Austin, TX 78712 USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Milner
authors.affiliation: Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92612 USA.
authors.forename: J Stuart
authors.initials: JS
authors.lastname: Nelson
keywords: Biological tissues; biomedical imaging; birefringence; optical tomography; polarization