title: Enhanced oral bioavailability of paclitaxel by solid dispersion granulation.
abstract: The main objective of this study was to develop novel orally administrable tablets containing solid dispersion granules (SDG) of amorphous paclitaxel (PTX) prepared by fluid bed technology, and to evaluate its in vitro dissolution and in vivo pharmacokinetics (PK) in beagle dogs. The SDG were prepared using optimized composition by fluid bed technology, and characterized for solid-state properties. The release study of SDG tablet (SDG-T) in simulated gastric fluid showed a rapid release of PTX, reaching maximum dissolution within 20 min. Finally, the PK profile of SDG-T and a reference formulation Oraxol™ (oral solution formulation used in Phase I clinical study) at a dose of 60 mg orally with co-administration of P-gp inhibitor HM38101, and Taxol® at a dose of 10 mg intravenously (i.v.) was investigated in beagle dogs. The mean absolute BA% of PTX following SDG-T and Oraxol™ solution was 8.23 and 6.22% in comparison to i.v. administration of Taxol®. The relative BA% of PTX from SDG-T in comparison to Oraxol™ solution was 132.25% at a dose of 60 mg following oral administration. In conclusion, we have successfully prepared PTX tablets with solid dispersion granules (SDG) of amorphous PTX using fluid bed technology that could provide plasma PTX concentration in the range of 10-150 ng/mL for a period of 24 h following oral administration in dogs with a P-gp inhibitor. Hence, this could be a promising formulation for PTX oral delivery and could be used in our intended clinical studies following pre-clinical efficacy studies.
authors.affiliation: a Pharm. R&D Institute, Hanmi Pharm. Co., Ltd. , Hwasung , Gyeonggi , Korea .
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Shanmugam
authors.affiliation: a Pharm. R&D Institute, Hanmi Pharm. Co., Ltd. , Hwasung , Gyeonggi , Korea .|b School of Pharmacy, Sungkyunkwan University , Suwon , Korea , and.
authors.forename: Ho Taek
authors.initials: HT
authors.lastname: Im
authors.affiliation: c College of Pharmacy, Duksung Women's University , Seoul , Korea.
authors.forename: Young Taek
authors.initials: YT
authors.lastname: Sohn
authors.affiliation: a Pharm. R&D Institute, Hanmi Pharm. Co., Ltd. , Hwasung , Gyeonggi , Korea .
authors.forename: Yong-Il
authors.initials: YI
authors.lastname: Kim
authors.affiliation: a Pharm. R&D Institute, Hanmi Pharm. Co., Ltd. , Hwasung , Gyeonggi , Korea .
authors.forename: Jae-Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: b School of Pharmacy, Sungkyunkwan University , Suwon , Korea , and.
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
authors.affiliation: a Pharm. R&D Institute, Hanmi Pharm. Co., Ltd. , Hwasung , Gyeonggi , Korea .
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001578:Benzopyrans / Q000494:pharmacology; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004285:Dogs; D065546:Drug Liberation; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013777:Tetrazoles / Q000494:pharmacology
chemical_list: C521083:4-oxo-4H-chromene-2-carboxylic acid (2-(2-(4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl)-2H-tetrazol-5-yl)-4,5-dimethoxyphenyl)amide; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D007546:Isoquinolines; D013607:Tablets; D013777:Tetrazoles; D017239:Paclitaxel
keywords: Dissolution; HM38101; fluid bed; oral bioavailability; paclitaxel; solid dispersion granules; spray drying