title: Zincation of 4,4-dimethyloxazoline using TMPZnCl·LiCl. A new preparation of 2-aryloxazolines.
abstract: The metalation of 4,4-dimethyloxazoline using TMPZnCl·LiCl provides a stable 2-zincated oxazolinyl reagent which readily undergoes palladium-catalyzed Negishi cross-couplings allowing a new access to 2-aryloxazolines. Cu-mediated acylation and allylation reactions also proceed in good yields.
authors.affiliation: Ludwig Maximilians-University Munich, Department of Chemistry, Butenandtstrasse 5-13, 81377 München, Germany. paul.knochel@cup.uni-muenchen.de.
authors.forename: Diana
authors.initials: D
authors.lastname: Haas
authors.forename: Maximilian S
authors.initials: MS
authors.lastname: Hofmayer
authors.forename: Tomke
authors.initials: T
authors.lastname: Bresser
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D010080:Oxazoles; D010880:Piperidines; C057549:4,4-dimethyloxazoline; C032727:piperidine; D015032:Zinc