title: [Intratumoral heterogeneity in renal cell carcinoma. Molecular basis and translational implications].
abstract: Advanced clear cell renal cell carcinoma is characterized by extensive intratumoral genomic heterogeneity and branched as well as convergent evolutionary traits with genomically different subclones evolving in parallel in the same tumor. Distinct driver mutations can be found in spatially separated subclones, which may hinder the development of novel targeted therapies. However, truncal mutations of the VHL tumor suppressor gene and chromosome 3p loss were ubiquitously detected and will hence continue to be a focus of future drug development. Nevertheless, genomic instability, enhanced tumor genome plasticity and intratumoral heterogeneity are likely to represent major challenges towards biomarker development and personalized patient care.
authors.affiliation: Sektion Molekulare Uroonkologie, Urologische Universitätsklinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 517, 69120, Heidelberg, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Höfflin
authors.forename: W
authors.initials: W
authors.lastname: Roth
authors.forename: H
authors.initials: H
authors.lastname: Sültmann
authors.forename: C
authors.initials: C
authors.lastname: Grüllich
authors.forename: G
authors.initials: G
authors.lastname: Hatiboglu
authors.forename: J
authors.initials: J
authors.lastname: Nyarangi-Dix
authors.forename: G
authors.initials: G
authors.lastname: Schönberg
authors.forename: D
authors.initials: D
authors.lastname: Teber
authors.forename: B
authors.initials: B
authors.lastname: Hadaschik
authors.forename: S
authors.initials: S
authors.lastname: Pahernik
authors.forename: M
authors.initials: M
authors.lastname: Hohenfellner
authors.forename: S
authors.initials: S
authors.lastname: Duensing
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000628:therapy; D000066670:Cell Plasticity / Q000235:genetics*; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease / Q000235:genetics; D015316:Genetic Therapy / Q000639:trends; D042822:Genomic Instability; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000628:therapy; D058990:Molecular Targeted Therapy / Q000639:trends; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D057170:Translational Research, Biomedical / Q000639:trends*
chemical_list: D009363:Neoplasm Proteins