title: MutY-glycosylase: an overview on mutagenesis and activities beyond the GO system.
abstract: MutY is a glycosylase known for its role in DNA base excision repair (BER). It is critically important in the prevention of DNA mutations derived from 7,8-dihydro-8-oxoguanine (8-oxoG), which are the major lesions resulting from guanine oxidation. MutY has been described as a DNA repair enzyme in the GO system responsible for removing adenine residues misincorporated in 8-oxoG:A mispairs, avoiding G:C to T:A mutations. Further studies have shown that this enzyme binds to other mispairs, interacts with several enzymes, avoids different transversions/transitions in DNA, and is involved in different repair pathways. Additional activities have been reported for MutY, such as the repair of replication errors in newly synthesized DNA strands through its glycosylase activity. Moreover, MutY is a highly conserved enzyme present in several prokaryotic and eukaryotic organisms. MutY defects are associated with a hereditary colorectal cancer syndrome termed MUTYH-associated polyposis (MAP). Here, we have reviewed the roles of MutY in the repair of mispaired bases in DNA as well as its activities beyond the GO system.
authors.affiliation: Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil; Departamento de Biofísica e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Ana Helena Sales
authors.initials: AH
authors.lastname: de Oliveira
authors.affiliation: Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Acarízia Eduardo
authors.initials: AE
authors.lastname: da Silva
authors.affiliation: Departamento de Biofísica e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Iuri Marques
authors.initials: IM
authors.lastname: de Oliveira
authors.affiliation: Departamento de Biofísica e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Instituto de Biotecnologia, Departamento de Ciências Biomédicas, Universidade de Caxias do Sul (UCS), Caxias do Sul, RS, Brazil.
authors.forename: João Antônio Pegas
authors.initials: JA
authors.lastname: Henriques
authors.affiliation: Departamento de Biologia Celular e Genética, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. Electronic address: lfagnez@ufrnet.br.
authors.forename: Lucymara Fassarella
authors.initials: LF
authors.lastname: Agnez-Lima
mesh_terms: D000818:Animals; D045647:DNA Glycosylases / Q000502:physiology*; D004260:DNA Repair / Q000235:genetics; D006151:Guanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*
chemical_list: D006151:Guanosine; C046215:8-hydroxyguanosine; D045647:DNA Glycosylases; C061738:mutY adenine glycosylase
keywords: DNA damage; DNA repair; GO system; MutY-glycosylase; Mutagenesis; Oxidative stress