title: An antioxidant-like action for non-peroxidisable phospholipids using ferrous iron as a peroxidation initiator.
abstract: The degradation of phospholipids containing polyunsaturated fatty acids, termed peroxidation, poses a constant challenge to membranes lipid composition and function. Phospholipids with saturated (e.g. PC 16:0/16:0) and monounsaturated fatty acids (e.g. PC 16:0/18:1) are some of the most common phospholipids found in membranes and are generally not peroxidisable. The present experiments show that these non-peroxidisable phospholipids, when present in liposomes with peroxidisable phospholipids (i.e. those containing polyunsaturated fatty acids) such as PC 16:0/18:2 and Soy PC, produce an inhibitory effect on rates of peroxidation induced by ferrous-iron. This inhibitory effect acts to extend the duration of the lag phase by several-fold. If present in natural systems, this action could enhance the capacity of conventional antioxidant mechanisms in membranes. The results of this preliminary work suggest that non-peroxidisable phospholipids may exert an antioxidant-like action in membranes.
authors.affiliation: School of Medicine (IHMRI), University of Wollongong, 2522, Australia. Electronic address: chc159@uowmail.edu.au.
authors.forename: Colin H
authors.initials: CH
authors.lastname: Cortie
authors.affiliation: School of Medicine (IHMRI), University of Wollongong, 2522, Australia.
authors.forename: Paul L
authors.initials: PL
authors.lastname: Else
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000737:chemistry; D010743:Phospholipids / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry
chemical_list: D000975:Antioxidants; D010713:Phosphatidylcholines; D010743:Phospholipids; D007501:Iron
keywords: Fatty acids; Ferrous iron; Liposomes; Membrane; Peroxidation