title: Kidney dysfunction and left ventricular assist device support: a comprehensive perioperative review.
abstract: Left ventricular assist devices (LVADs) are used increasingly as a bridge to transplantation or as destination therapy in end-stage heart failure patients who do not respond to optimal medical therapy. Many of these patients have end-organ dysfunction, including advanced kidney dysfunction, before and after LVAD implantation. Kidney dysfunction is a marker of adverse outcomes, such as increased morbidity and mortality. This review discusses kidney dysfunction and associated management strategies during the dynamic perioperative time period of LVAD implantation. Furthermore, we suggest potential future research directions to better understand the complex relationship between renal pathophysiology and mechanical circulatory support.
authors.affiliation: Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Samuel T
authors.initials: ST
authors.lastname: Coffin
authors.affiliation: Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Dia R
authors.initials: DR
authors.lastname: Waguespack
authors.affiliation: Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Haglund
authors.affiliation: Division of Cardiovascular Surgery, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Maltais
authors.affiliation: Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Jamie P
authors.initials: JP
authors.lastname: Dwyer
authors.affiliation: Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tenn., USA.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Keebler
keywords: Heart failure; Kidney injury; Ventricular assist device