title: Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study.
abstract: OBJECTIVE
  We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients.
  
  
  METHODS
  aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549).
  
  
  RESULTS
  Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P < 0.0001). At multivariate analysis, aCT (P = 0.011), β-2 microglobulin (P = 0.019), and CD38 expression (P = 0.047) correlated with TTFT. Following IWCLL 2008 criteria, 112 (61.9%) cases remained at Rai 0, while 69 (38.1%) satisfied the criteria of clinical monoclonal B-cell lymphocytosis (cMBL). Reclassified Rai 0 patients with an abnormal aCT showed a significantly shorter TTFT than those with a normal aCT (P < 0.0001). At multivariate analysis, only aCT (P = 0.011) correlated with TTFT. Eleven cMBL cases (15.9%) showed an abnormal aCT and were reclassified as small lymphocytic lymphomas (SLL); nonetheless, TTFT was similar for cMBLs and SLLs.
  
  
  CONCLUSIONS
  Our results confirm the ability of the abnormal aCT to predict progression in early stage cases.
authors.affiliation: Hematology Unit, Department of Onco-Hematology, A.O. of Cosenza, Cosenza, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Gentile
authors.affiliation: SS Molecular Diagnostics IRCCS S. Martino-IST, Genova, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Cutrona
authors.affiliation: Department of Oncology and Haematology, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Molica
authors.affiliation: Division of Haematology, A.O. S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Ilariucci
authors.affiliation: Divisione di Ematologia, Università La Sapienza, Rome, Italy.
authors.forename: Francesca R
authors.initials: FR
authors.lastname: Mauro
authors.affiliation: Hematology Unit, Ospedale Vito Fazzi, Lecce, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Renzo
authors.affiliation: Division of Haematology, Department of Biomedical Sciences, University of Catania and Ferrarotto Hospital, Catania, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Raimondo
authors.affiliation: Hematology Unit, A.O. of Reggio Calabria, Reggio, Italy.
authors.forename: Iolanda
authors.initials: I
authors.lastname: Vincelli
authors.affiliation: Laboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy.
authors.forename: Katia
authors.initials: K
authors.lastname: Todoerti
authors.affiliation: Direzione Scientifica IRCCS, San Martino IST, Genova, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Matis
authors.affiliation: Division of Haematology, University of Messina, Messina, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Musolino
authors.affiliation: Department of Clinical Sciences and Community Health, University of Milano and Hematology CTMO, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Sonia
authors.initials: S
authors.lastname: Fabris
authors.affiliation: Department of Clinical Sciences and Community Health, University of Milano and Hematology CTMO, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Lionetti
authors.affiliation: Department of Oncology and Haematology, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Levato
authors.affiliation: SS Molecular Diagnostics IRCCS S. Martino-IST, Genova, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Zupo
authors.affiliation: Department of Hematology, Ospedale Santo Spirito, Pescara, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Angrilli
authors.affiliation: U.O.S. di Emato-Oncologia, Ospedale Garibaldi-Nesima, Catania, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Consoli
authors.affiliation: Centro di Riferimento Ematologico-Seconda Medicina, Azienda Ospedaliero-Universitaria, Ospedali Riuniti, Trieste, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Festini
authors.affiliation: Unità di Ematologia, Ospedale San Vincenzo, Taormina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Longo
authors.affiliation: Laboratory of Preclinical and Translational Research, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy.
authors.forename: Agostino
authors.initials: A
authors.lastname: Cortelezzi
authors.affiliation: Scientific Direction, IRCCS, Referral Cancer Center of Basilicata, Rionero in Vulture (Pz), Italy.
authors.forename: Pellegrino
authors.initials: P
authors.lastname: Musto
authors.affiliation: Department of Onco-hematology, Università di Modena Centro Oncologico Modenese, Policlinico Modena, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
authors.affiliation: Department of Clinical Sciences and Community Health, University of Milano and Hematology CTMO, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Neri
authors.affiliation: Direzione Scientifica IRCCS, San Martino IST, Genova, Italy.
authors.forename: Manlio
authors.initials: M
authors.lastname: Ferrarini
authors.affiliation: Hematology Unit, Department of Onco-Hematology, A.O. of Cosenza, Cosenza, Italy.
authors.forename: Fortunato
authors.initials: F
authors.lastname: Morabito
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000097:blood; D000005:Abdomen; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D001613:beta 2-Microglobulin; D051997:ADP-ribosyl Cyclase 1
keywords: abdominal CT scan; chronic lymphocytic leukemia; clinical monoclonal B-cell lymphocytosis; early stage; prognosis