title: 5-Methyl-tetrahydrofolate in prevention of recurrent preeclampsia.
abstract: OBJECTIVE
  To evaluate the efficacy of 5-methyl-tetrahydrofolate (5-MTHF) supplementation in prevention of recurrent preeclampsia.
  
  
  METHODS
  Retrospective cohort of women who received daily oral 5-MTHF 15 mg supplementation as prophylactic treatment since first trimester for recurrent preeclampsia were compared with women who did not. All asymptomatic singleton gestations with prior preeclampsia (in the previous pregnancy) were included. Women with chronic hypertension were excluded. The primary outcome was the incidence of preeclampsia.
  
  
  RESULTS
  Three hundred and three singleton gestation met the inclusion criteria: 157 received 5-MTHF, while 146 did not (control group). Women who received 5-MTHF had a significantly lower incidence of recurrent overall preeclampsia (21.7% versus 39.7%; odds ratio (OR) 0.57, 95% confidence interval (CI) 0.25, 0.69), severe preeclampsia (3.2% versus 8.9%; OR 0.44, 95% CI 0.12-0.97) and early-onset preeclampsia (1.9% versus 7.5%; OR 0.34, 95% CI 0.07-0.87) compared to control. The intervention group delivered about 10 d after the control and had higher birth weight.
  
  
  CONCLUSIONS
  This retrospective study showed that women with prior preeclampsia who received daily oral 5-MTHF 15 mg supplementation had a significantly lower incidence of overall preeclampsia, severe preeclampsia and early-onset preeclampsia. Randomized controlled trials are needed to confirm our findings.
authors.affiliation: a Department of Neuroscience , Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II , Naples , Italy and.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Saccone
authors.affiliation: a Department of Neuroscience , Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II , Naples , Italy and.
authors.forename: Laura
authors.initials: L
authors.lastname: Sarno
authors.affiliation: b Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology , Sidney Kimmel Medical College of Thomas Jefferson University , Philadelphia , PA , USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Roman
authors.affiliation: a Department of Neuroscience , Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II , Naples , Italy and.
authors.forename: Vera
authors.initials: V
authors.lastname: Donadono
authors.affiliation: a Department of Neuroscience , Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II , Naples , Italy and.
authors.forename: Giuseppe Maria
authors.initials: GM
authors.lastname: Maruotti
authors.affiliation: a Department of Neuroscience , Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II , Naples , Italy and.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Martinelli
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies; D013763:Tetrahydrofolates / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D013763:Tetrahydrofolates; C005984:5-methyltetrahydrofolate
keywords: Folic acid; hypertension; prevention; recurrent; supplementation