title: Binge eating disorder and medical comorbidities in bariatric surgery candidates.
abstract: OBJECTIVE
  To determine whether binge eating disorder (BED) status is associated with medical comorbidities in obese adults scheduled for bariatric surgery.
  
  
  METHODS
  The study utilized Longitudinal Assessment of Bariatric Surgery-2 data obtained from six clinical centers around the United States. This is a well-phenotyped cohort of individuals who were evaluated within 30 days before their scheduled surgery using standardized protocols. In the cohort, 350 participants were classified as having BED and 1,875 as not having BED (non-BED). Multivariable logistic regression was used to determine whether BED status was independently related to medical comorbidities. As an exploratory analysis, significance was based on nominal p-values (p < .05). Holm's-adjusted p-values were also reported.
  
  
  RESULTS
  After adjusting for age, sex, education, and body mass index, BED status was found to be independently associated with four of the 15 comorbidities (i.e., impaired glucose levels (odds ratio [OR] = 1.45 (95% confidence interval [CI]: 1.12-1.87)), high triglycerides (OR = 1.28 (95% CI: 1.002-1.63)), and urinary incontinence (OR = 1.30 (95% CI: 1.02-1.66)), all being more common among the BED sample, and severe walking limitations being less common in the BED sample (OR = 0.53 (95% CI: 0.29-0.96)). With further adjustment for psychiatric/emotional health indicators, BED status was independently associated with three comorbidities (impaired glucose levels (OR = 1.36 (95% CI: 1.04-1.79)), cardiovascular disease (OR = 0.50 (95% CI: 0.30-0.86)), and severe walking limitations (OR = 0.38 (95% CI: 0.19-0.77)). However, Holm's-adjusted p-values for all variables were greater than .05.
  
  
  CONCLUSIONS
  The results suggest the possibility of a contribution of BED to risk of specific medical comorbidities in severely obese adults.
authors.affiliation: Neuropsychiatric Research Institute, Fargo, North Dakota.
authors.forename: James E
authors.initials: JE
authors.lastname: Mitchell
authors.affiliation: Data Coordinating Center, Graduate School of Public Health at the University of Pittsburgh, Pittsburgh, Pennsylvania.
authors.forename: Wendy C
authors.initials: WC
authors.lastname: King
authors.affiliation: Department of Surgery, East Carolina Medical Center, Greenville, North Carolina.
authors.forename: Walter
authors.initials: W
authors.lastname: Pories
authors.affiliation: Department of Surgery, Oregon Health and Science University, Portland, Oregon.
authors.forename: Bruce
authors.initials: B
authors.lastname: Wolfe
authors.affiliation: Department of Surgery, University of Washington, Seattle, Washington.
authors.forename: David R
authors.initials: DR
authors.lastname: Flum
authors.affiliation: Department of Surgery, East Carolina Medical Center, Greenville, North Carolina.
authors.forename: Konstatinos
authors.initials: K
authors.lastname: Spaniolas
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York City, New York.
authors.forename: Mark
authors.initials: M
authors.lastname: Bessler
authors.affiliation: Department of Psychiatry, Columbia University Medical Center, New York City, New York.
authors.forename: Michael
authors.initials: M
authors.lastname: Devlin
authors.affiliation: Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
authors.forename: Marsha D
authors.initials: MD
authors.lastname: Marcus
authors.affiliation: College of Nursing, Dusquesne University, Pittsburgh, Pennsylvania.
authors.forename: Melissa
authors.initials: M
authors.lastname: Kalarchian
authors.affiliation: Neuropsychiatric Research Institute, Fargo, North Dakota.
authors.forename: Scott
authors.initials: S
authors.lastname: Engel
authors.affiliation: Department of Surgery, University of Washington, Seattle, Washington.
authors.forename: Saurobh
authors.initials: S
authors.lastname: Khandelwal
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
authors.forename: Susan
authors.initials: S
authors.lastname: Yanovski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050110:Bariatric Surgery / Q000523:psychology*; D056912:Binge-Eating Disorder / Q000150:complications* / Q000523:psychology; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000523:psychology; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000523:psychology / Q000601:surgery; D055815:Young Adult
keywords: binge eating disorder; medical comorbidities; metabolic syndrome