title: Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration.
abstract: Wound healing is a complex biological process that depends on the wound condition, the patient's health, and the physicochemical support given through external materials. The development of bioactive molecules and engineered tissue substitutes to provide physiochemical support to enhance the wound healing process plays a key role in advancing wound-care management. Thus, identification of ideal molecules in wound treatment is still in progress. The discovery of natural products that contain ideal molecules for skin tissue regeneration has been greatly advanced by exploration of the marine bioenvironment. Consequently, tremendously diverse marine organisms have become a great source of numerous biological macromolecules that can be used to develop tissue-engineered substitutes with wound healing properties. This review summarizes the wound healing process, the properties of macromolecules from marine organisms, and the involvement of these molecules in skin tissue regeneration applications.
authors.affiliation: Department of Biomedical Engineering, and Centre for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Pathum
authors.initials: P
authors.lastname: Chandika
authors.affiliation: Institute of Marine Biotechnology, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Seok-Chun
authors.initials: SC
authors.lastname: Ko
authors.affiliation: Department of Biomedical Engineering, and Centre for Marine-Integrated Biomedical Technology (BK21 Plus) Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: wkjung@pknu.ac.kr.
authors.forename: Won-Kyo
authors.initials: WK
authors.lastname: Jung
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects*; D012867:Skin / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001672:Biocompatible Materials; D046911:Macromolecular Substances
keywords: Biological macromolecules; Marine organisms; Skin tissue engineering; Wound healing