title: Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expression.
abstract: The molecular mechanism for chromatin remodeling and chromosomal interactions at the Th2 cytokine locus is not fully understood. Recently, we showed that transcription factor YY1 is critically involved in these events. This article discusses the possible roles of YY1 in these processes with particular emphasis on long-range chromosomal interactions.
authors.affiliation: a Department of Life Science; Sogang University; Seoul, Korea.
authors.forename: Gap Ryol
authors.initials: GR
authors.lastname: Lee
mesh_terms: D000818:Animals; D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D015530:Nuclear Matrix / Q000378:metabolism; D063146:Polycomb-Group Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D018418:Th2 Cells; D015533:Transcriptional Activation; D050986:YY1 Transcription Factor / Q000378:metabolism*; D000097722:Cohesins
chemical_list: D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D016207:Cytokines; D063146:Polycomb-Group Proteins; D012097:Repressor Proteins; D050986:YY1 Transcription Factor; D000097722:Cohesins; C000619697:CTCF protein, human; C494698:YY1 protein, human
keywords: Th2 cytokine locus; Th2 differentiation; YY1; chromatin remodeling; chromosomal interaction; transcription factor