title: Portable hemoglobinometer is a reliable technology for the follow-up of venesections tolerance in hemochromatosis.
abstract: BACKGROUND
  The treatment of HFE-related hemochromatosis, one of the most common genetic diseases, is based on phlebotomies whose tolerance is evaluated by regular monitoring of hemoglobin. Using a portable hemoglobinometer (PH) could provide an easy and fast determination of hemoglobin. Therefore, the aim of the present study was to compare, in hemochromatosis patients treated by bloodletting, the hemoglobin concentrations as assayed, on capillary blood, by a PH device and, on venous blood, by a cell counter (CC) device.
  
  
  METHODS
  For a total period of 12 weeks duration, all patients undergoing phlebotomies in the same hospital outpatient unit had hemoglobin determinations both by the HemoCue and by the laboratory's DxH 800 Coulter. To evaluate the sensitivity and specificity of the HemoCue, patients were classified as presenting or not anemia as defined by hemoglobin level below 11 g/dl.
  
  
  RESULTS
  Measurements of hemoglobin were performed in 122 patients. The sensitivity and specificity of PH compared to CC were 100 and 98.1%, respectively. Capillary hemoglobin by PH slightly underestimated venous hemoglobin by CC. The Pearson's correlation coefficient between PH and CC was 0.80 (P<0.0001).
  
  
  CONCLUSIONS
  PH is a reliable, quick and easy technology, which can be proposed to follow-up the tolerance of venesections in hemochromatosis patients.
authors.affiliation: Laboratory of Biochemistry, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Pawlowski
authors.affiliation: Laboratory of Biochemistry, University Hospital Pontchaillou, 35033 Rennes, France. Electronic address: fanny.latute@hotmail.fr.
authors.forename: Fanny
authors.initials: F
authors.lastname: Latute
authors.affiliation: Inserm UMR991, University of Rennes 1, 35033 Rennes France; Liver Disease Department, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Bardou-Jacquet
authors.affiliation: Liver Disease Department, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Latournerie
authors.affiliation: Liver Disease Department, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Selim
authors.initials: S
authors.lastname: Zerrouki
authors.affiliation: Laboratory of Biochemistry, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Bendavid
authors.affiliation: Inserm UMR991, University of Rennes 1, 35033 Rennes France; Liver Disease Department, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
authors.affiliation: Laboratory of Biochemistry, University Hospital Pontchaillou, 35033 Rennes, France; Liver Disease Department, University Hospital Pontchaillou, 35033 Rennes, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Ropert
mesh_terms: D000740:Anemia / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006432:Hemochromatosis / Q000628:therapy*; D006452:Hemoglobinometry / Q000295:instrumentation* / Q000379:methods; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010045:Outpatients; D018962:Phlebotomy / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014680:Veins
chemical_list: D006454:Hemoglobins