title: Relation of vitamin D deficiency and new-onset atrial fibrillation among hypertensive patients.
abstract: Vitamin D deficiency is associated with various cardiovascular disorders including hypertension, coronary artery disease, and heart failure. The renin-angiotensin-aldosterone system (RAS) axis is activated in vitamin D deficiency. The RAS axis also plays a role in the pathophysiology of atrial fibrillation (AF). We aimed to investigate whether vitamin D deficiency is a risk factor for the development of new-onset AF in hypertension. A total of 227 hypertensive patients were enrolled, of whom 137 had new-onset AF; 90 patients without AF were included in the control group. The age of the patient, left atrial diameter, and vitamin D deficiency increased the probability of new-onset AF independent from confounding factors (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.01-1.08; P = .03 for age; OR, 1.88; 95% CI, 1.15-3.45; P = .03 for left atrial diameter; OR, 1.68; 95% CI, 1.18-2.64; P = .03 for vitamin D deficiency). Vitamin D deficiency is associated with new-onset AF in hypertension.
authors.affiliation: Cardiology Department, Ankara University, Ankara, Turkey. Electronic address: ozgurulasozcan@yahoo.com.tr.
authors.forename: Ozgur Ulas
authors.initials: OU
authors.lastname: Ozcan
authors.affiliation: Cardiology Department, Ankara University, Ankara, Turkey.
authors.forename: Adalet
authors.initials: A
authors.lastname: Gurlek
authors.affiliation: Cardiology Department, Ankara University, Ankara, Turkey.
authors.forename: Eren
authors.initials: E
authors.lastname: Gursoy
authors.affiliation: Cardiology Department, Ankara University, Ankara, Turkey.
authors.forename: Demet Menekse
authors.initials: DM
authors.lastname: Gerede
authors.affiliation: Cardiology Department, Ankara University, Ankara, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Erol
mesh_terms: D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000150:complications*; D016022:Case-Control Studies; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014808:Vitamin D Deficiency / Q000150:complications*
keywords: Arrhythmia; case-control study; nutrition; renin-angiotensin-aldosterone system