title: Mobilisation of haematopoietic stem cells in paediatric patients, prior to autologous transplantation following administration of plerixafor and G-CSF.
abstract: Previous chemotherapy and radiation exposure can make adequate stem cell mobilisation prior to autologous transplant extremely difficult in paediatrics. Plerixafor, a selective reversible CXCR4 antagonist interferes with CXCR4 interaction with Stromal cell-derived factor 1 alpha (SDF-1). Combination with granulocyte-colony stimulating factor (G-CSF) amplifies G-CSF affects in mobilising haematopoietic stem cells. Whilst licensed for use with G-CSF for enhancement of mobilisation of haematopoietic stem cells in adults, paediatric data for use of plerixafor remain limited. We present a retrospective review of outcomes seen with plerixafor and G-CSF to mobilise stem cells heavily pre-treated paediatric patients with cancer.
authors.affiliation: The Harley Street Clinic, London, United Kingdom.
authors.forename: Bhumik
authors.initials: B
authors.lastname: Patel
authors.affiliation: The Harley Street Clinic, London, United Kingdom.|The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom.
authors.forename: Helen
authors.initials: H
authors.lastname: Pearson
authors.affiliation: The Harley Street Clinic, London, United Kingdom.|The Royal Marsden NHS Foundation Trust, Surrey, United Kingdom.
authors.forename: Stergios
authors.initials: S
authors.lastname: Zacharoulis
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D018952:Antigens, CD34 / Q000378:metabolism; D001596:Benzylamines; D054377:Chemokine CXCL12 / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D000080027:Cyclams; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000628:therapy; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D018952:Antigens, CD34; D001596:Benzylamines; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D000080027:Cyclams; D006571:Heterocyclic Compounds; D019718:Receptors, CXCR4; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: CD34 positive stem cell; children; oncology; plerixafor; stem cell mobilisation