title: [Oxidative stress in pathogenesis of bronchial asthma: a method of correction by inhalation of phospholipid nanoparticles].
abstract: The authors present the results of a prospective simple blind randomized placebo-controlled study for the evaluation of dynamics of biomarkers of oxidative stress (total concentration of nitrate- and nitrite-anions in condensed exhaled breath and plasma, pH of exhaled breath, total antioxidative activity of plasma in patients with bronchial asthma inhaling phospholipid nanoparticles. The results suggest significant positive effect of proposed therapy on dynamics of the main parameters of oxidative stress including reduced concentration of nitric oxide metabolites and increased total antioxidative activity of plasma. No clinically significant reactions were documented.
authors.forename: A V
authors.initials: AV
authors.lastname: Lisitsa
authors.forename: S K
authors.initials: SK
authors.lastname: Soodaeva
authors.forename: I A
authors.initials: IA
authors.lastname: Klimanov
authors.forename: A V
authors.initials: AV
authors.lastname: Aver'ianov
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests / Q000379:methods; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles; D009566:Nitrates / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D010743:Phospholipids / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D010743:Phospholipids; D009569:Nitric Oxide