title: Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.
abstract: The growing prevalence of Alzheimer's disease (AD) has warranted the development of effective therapeutic methods. Current available drugs for AD (i.e., acetylcholinesterase (AChE) inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists) have only offered brief symptomatic relief. Considering that the numbers affected by AD are projected to substantially rise, long-term strategies are urgently needed. The multiple series of small molecules to combat AD have been expanded, with current methods taking aim at factors, such as misfolded protein accumulation, metal ion dyshomeostasis, and oxidative stress. This concept article focuses on describing the design of compounds to target various components of AD and underlining recent advances that have been made.
authors.affiliation: Department of Chemistry, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Eonyan-eup, Ulju-gun, Ulsan (Korea).
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Derrick
authors.forename: Mi Hee
authors.initials: MH
authors.lastname: Lim
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry; D000818:Animals; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D054852:Small Molecule Libraries / Q000494:pharmacology* / Q000627:therapeutic use; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D054852:Small Molecule Libraries; D016875:tau Proteins
keywords: Alzheimer's disease; amyloid-beta peptides; drug design; multifunctional small molecules; tau protein