title: Two new phenolic glucosides from Lagerstroemia speciosa.
abstract: Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC50 values of 69.5-83.3 μM.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea. dashutiao@naver.com.
authors.forename: Janggyoo
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea. jaecho@skku.edu.
authors.forename: Jae Youl
authors.initials: JY
authors.lastname: Cho
authors.affiliation: College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. wjd6694@naver.com.
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. tkghs35@naver.com.
authors.forename: Heejin
authors.initials: H
authors.lastname: Jeon
authors.affiliation: Department of Life Science, Hallym University, Chuncheon 200-702, Korea. ydkim@hallym.ac.kr.
authors.forename: Young Dong
authors.initials: YD
authors.lastname: Kim
authors.affiliation: Popa mountain park, Forest Department, Kyaukpadaung Township, Mandalay Division, Myanmar. khinmyohtwe007@gmail.com.
authors.forename: Khin Myo
authors.initials: KM
authors.lastname: Htwe
authors.affiliation: College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsan dong-gu, Goyang 410-820, Korea. f2744@dongguk.edu.
authors.forename: Young Won
authors.initials: YW
authors.lastname: Chin
authors.affiliation: Department of Forest Sciences, Seoul National University, Seoul 151-921, Korea. krane@snu.ac.kr.
authors.forename: Woo Shin
authors.initials: WS
authors.lastname: Lee
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea. dashutiao@naver.com.
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
authors.affiliation: College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea. kdyoon@catholic.ac.kr.
authors.forename: Kee Dong
authors.initials: KD
authors.lastname: Yoon
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D031563:Lagerstroemia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C000603052:1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-beta-D-glucopyranoside; C000603051:1-O-benzyl-6-O-E-caffeoyl-beta-D-glucopyranoside; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide