title: Diffusion in the corpus callosum in patients with early schizophrenia.
abstract: Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia.
authors.affiliation: Research Institute of Urgent Pediatric Surgery and Traumatology, Moscow, Russian Federation.
authors.forename: M V
authors.initials: MV
authors.lastname: Ublinskii
authors.forename: N A
authors.initials: NA
authors.lastname: Semenova
authors.forename: O V
authors.initials: OV
authors.lastname: Lukovkina
authors.forename: S V
authors.initials: SV
authors.lastname: Sidorin
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.forename: T A
authors.initials: TA
authors.lastname: Akhadov
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D003337:Corpus Callosum / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D055815:Young Adult
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate