title: Spontaneous isolated superior mesenteric artery dissection: genetic heterogeneity of chromosome locus 5q13-14 in 2 male familial cases.
abstract: Spontaneous isolated superior mesenteric artery dissection (SISMAD) is a rare disease that occurs sporadically. In this report, we describe 2 cases of SISMAD involving an uncle and his nephew. Genetic studies revealed the presence of heterogeneity of a chromosome locus at 5q13-14 in 3 family members (the 2 patients and the nephew's mother), an area previously found to be linked to familial ascending aortic aneurysms and dissections.
authors.affiliation: Department of Interventional Radiography, The Second Hospital of Chanzhou Affiliated to Nanjing Medical University, Chang Zhou, Jiangsu Province, China.
authors.forename: Zhongzhi
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Department of Interventional Radiology, Shanghai 10th People's Hospital, Nanjing Medical University, Shanghai, China; Institute of Medical Intervention Engineering, Tongji University, Shanghai, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Mayo Clinic, Jacksonville, FL.
authors.forename: Weiping
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Interventional Radiography, The Second Hospital of Chanzhou Affiliated to Nanjing Medical University, Chang Zhou, Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.affiliation: Department of Interventional Radiography, The Second Hospital of Chanzhou Affiliated to Nanjing Medical University, Chang Zhou, Jiangsu Province, China. Electronic address: 747094035@qq.com.
authors.forename: Guomin
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Department of Interventional Radiology, Shanghai 10th People's Hospital, Nanjing Medical University, Shanghai, China; Institute of Medical Intervention Engineering, Tongji University, Shanghai, China.
authors.forename: Maoquan
authors.initials: M
authors.lastname: Li
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D000792:Angiography; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D057510:Endovascular Procedures / Q000379:methods*; D018740:Genetic Heterogeneity; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D017538:Mesenteric Artery, Superior; D008875:Middle Aged; D010375:Pedigree; D014057:Tomography, X-Ray Computed