title: Synthesis, characterization, and biological evaluation of Schiff base-platinum(II) complexes.
abstract: The platinum complexes of Schiff base ligands derived from 4-aminoantipyrine and a few substituted aldehydes were synthesized and characterized by elemental analysis, mass, (1)H NMR, IR, electronic spectra, molar conductance, and powder XRD. The structure of one of the ligands L5 was confirmed by a single crystal XRD analysis. The Schiff base ligand crystallized in the triclinic, space group P-1 with a=7.032(2)Ǻ, b=9.479(3)Ǻ, c=12.425(4)Ǻ, α=101.636(3)°, β=99.633(3)°, γ=94.040(3)°, V=795.0(4)Ǻ(3), Z=2, F(000)=352, Dc=1.405 mg/m(3), μ=0.099 mm(-1), R=0.0378, and wR=0.0967. The spectral results show that the Schiff base ligand acts as a bidentate donor coordinating through the azomethine nitrogen and the carbonyl oxygen atoms. The geometrical structures of these complexes are found to be square planar. Antimicrobial studies indicate that these complexes exhibit better activity than the ligand. The anticancer activities of the complexes have also been studied towards human cervical cancer cell line (HeLa), Colon Cancer Cells (HCT116) and Epidermoid Carcinoma Cells (A431) and it was found that the [Pt(L3)Cl2] complex is more active.
authors.affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli 627 012, TN, India.
authors.forename: C
authors.initials: C
authors.lastname: Shiju
authors.affiliation: Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli 627 012, TN, India.
authors.forename: D
authors.initials: D
authors.lastname: Arish
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77842, USA.
authors.forename: N
authors.initials: N
authors.lastname: Bhuvanesh
authors.affiliation: Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli 627 012, TN, India. Electronic address: skumarmsu@yahoo.com.
authors.forename: S
authors.initials: S
authors.lastname: Kumaresan
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010984:Platinum / Q000494:pharmacology*; D011208:Powders; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D056831:Coordination Complexes; D008024:Ligands; D011208:Powders; D012545:Schiff Bases; D010984:Platinum
keywords: Anticancer; Antimicrobial; Antitubercular; Platinum complexes; Schiff base