title: [Expression of PPAR-γ in patients with chronic rhinosinusitis without or with nasal polyps].
abstract: OBJECTIVE
  To investigate the expression of peroxisome proliferator-activated receptor γ (PPAR-γ) in the sinus mucosa of chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP).
  
  
  METHODS
  Using immunohistochemistry and RT-PCR, testing the content of PPAR-γ in sinus mucosa and nasal polyps of patients with chronic sinusitis without nasal polyps and normal inferior turbinate, and analyzing the differences.
  
  
  RESULTS
  The PPAR-γ was found both in sinus mucosa of CRSsNP, nasal polyps of CRSwNP and in normal inferior turbinate; (2) The expression of PPAR-γ in sinus mucosa of CRSsNP and nasal polyps of CRSwNP was lower than that in normal inferior turbinate tissue, and the differences was prominent in statistics; (3) No differences in the expression of PPAR-γ were obtained in sinus mucosa of CRSsNP and nasal polyps of CRSwNP.
  
  
  CONCLUSIONS
  The PPAR-γ expressed in human nasal mucosa, meanwhile it was descending in sinus mucosa of CRSsNP and nasal polyps of CRSwNP. The long-term inflammations resulted from CRSsNP and nasal polyps of CRSwNP might relate to PPAR-γ, it suggested that PPAR-γ agonists may offer a new therapy for the treatment of Chronic Rhinosinusitis.
authors.forename: Xianbing
authors.initials: X
authors.lastname: Peng
authors.forename: Weijia
authors.initials: W
authors.lastname: Kong
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D002908:Chronic Disease; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation; D009297:Nasal Mucosa; D009298:Nasal Polyps / Q000378:metabolism*; D047495:PPAR gamma / Q000096:biosynthesis*; D012220:Rhinitis / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism*; D014420:Turbinates
chemical_list: D047495:PPAR gamma