title: [Lifecycles of EBV and cancer].
abstract: Epstein-Barr virus (EBV) is a member of gamma-herpesvirus, which can cause various types of tumor. Coexisting with the host for a long period of time, it has evolved unique and sophisticated strategy for survival by taking complicated, tactical modes of infection. Such modes include latent and lytic infections, and latent state is further categorized into four types. Differences and transitions in such lifestyles are significantly associated not only with virus amplification, but also with pathology and advancement of the disorders. I here review oncogenesis and pathogenesis of EBV-related disorders, especially focusing on our recent results on the modes of EBV infection.
authors.affiliation: Division of Virology, Aichi Cancer Center Research Institute, Present affiliation：Department of Virology, Nagoya University Graduate School of Medicine.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murata
mesh_terms: D000818:Animals; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D006801:Humans; D008018:Life Cycle Stages; D008214:Lymphocytes / Q000473:pathology; D009369:Neoplasms / Q000473:pathology / Q000821:virology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D014775:Virus Activation / Q000235:genetics; D017735:Virus Latency / Q000235:genetics; D014779:Virus Replication
chemical_list: C063676:BZLF1 protein, Herpesvirus 4, Human; D015534:Trans-Activators