title: Risk of hip fractures in men with alpha-blockers: a nationwide study base on claim registry.
abstract: BACKGROUND
  Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database.
  
  
  METHODS
  We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR).
  
  
  RESULTS
  Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker.
  
  
  CONCLUSIONS
  Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
authors.affiliation: Health Insurance Review and Assessment Service, Seoul, Korea.
authors.forename: Gi-Hyeon
authors.initials: GH
authors.lastname: Seo
authors.affiliation: Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Young-Kyun
authors.initials: YK
authors.lastname: Lee
authors.affiliation: Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Yong-Chan
authors.initials: YC
authors.lastname: Ha
keywords: Alpha-blocker; Hip fracture; Registries