title: Radiation therapy for nasal vestibule squamous cell carcinoma: a 40-year experience.
abstract: We evaluated the treatment of squamous cell carcinoma (SCC) of the nasal vestibule. Eighty-six patients were treated with radiotherapy (RT) and 13 patients received surgery and RT. The mean follow-up was: 9.7 years (range 4 months-35.9 years). The 5- and 10-year outcomes were: local control (LC), 88 and 82 %; local-regional control (LRC), 78 and 73 %; freedom from distant metastases (FFDM), 96 and 96 %; cause-specific survival (CSS), 91 and 86 %; and overall survival, 75 and 51 %. The 5- and 10-year LC rates for patients treated with RT were 94 and 89 % overall. A multivariate analysis was performed. Tumor size predicted LC, LRC, OS, and CSS. Overall stage predicted LRC. RT cures most patients with T1-T2 and favorable T4 SCCs with acceptable toxicity. RT and surgery result in improved likelihood of cure for patients with advanced T4 lesions.
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL, 32610-0385, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Wray
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL, 32610-0385, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Morris
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL, 32610-0385, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Kirwan
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL, 32610-0385, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Amdur
authors.affiliation: Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: John W
authors.initials: JW
authors.lastname: Werning
authors.affiliation: Department of Otolaryngology, College of Medicine, University of Florida, Gainesville, FL, USA.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Dziegielewski
authors.affiliation: Department of Radiation Oncology, College of Medicine, University of Florida, 2000 SW Archer Rd., PO Box 100385, Gainesville, FL, 32610-0385, USA. mendwm@shands.ufl.edu.
authors.forename: William M
authors.initials: WM
authors.lastname: Mendenhall
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology*; D059747:Nasal Surgical Procedures / Q000379:methods*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000473:pathology / Q000532:radiotherapy; D011878:Radiotherapy / Q000379:methods*; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Head and neck cancer; Nasal vestibule; Neck dissection; Outcomes; Radiotherapy