title: Lumazine peptides from the marine-derived fungus Aspergillus terreus.
abstract: Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of the marine-derived fungus Aspergillus terreus. From the results of combined spectroscopic and chemical analyses, the structures of these compounds were determined to be linear assemblies of 1-methyllumazine-6-carboxylic acid, an amino acid residue and anthranilic acid methyl ester connected by peptide bonds. These new compounds exhibited pharmacological activity by improving insulin sensitivity, which was evaluated in an adipogenesis model using human bone marrow mesenchymal stem cells. In addition, the compounds exhibited fluorescence changes upon binding to DNA, demonstrating their potential applications to DNA sequence recognition.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lovemin90@snu.ac.kr.
authors.forename: Minjung
authors.initials: M
authors.lastname: You
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. lxycxf@snu.ac.kr.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Liao
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. hong-soo-hyun@hanmail.net.
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Hong
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. adamas2001@hanmail.net.
authors.forename: Wanki
authors.initials: W
authors.lastname: Park
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. dahin@snu.ac.kr.
authors.forename: Dah In
authors.initials: DI
authors.lastname: Kwon
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. jyleeut@snu.ac.kr.
authors.forename: Jeeyeon
authors.initials: J
authors.lastname: Lee
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. minsoonoh@snu.ac.kr.
authors.forename: Minsoo
authors.initials: M
authors.lastname: Noh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. dongchanoh@snu.ac.kr.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.affiliation: Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea. ohkibong@snu.ac.kr.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea. shinj@snu.ac.kr.
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D050156:Adipogenesis / Q000187:drug effects; D001230:Aspergillus / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D005453:Fluorescence; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011621:Pteridines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D010455:Peptides; D011621:Pteridines; C008297:lumazine; D004247:DNA