title: Intrauterine Growth Restricted Rats Exercised at Pregnancy: Maternal-Fetal Repercussions.
abstract: To evaluate the effect of swimming in pregnant rats born with intrauterine growth restriction (IUGR) and their offspring, IUGR rats were obtained using the streptozotocin-induced severe diabetic (SD) rats. In this study, the nondiabetic parental generation presented 10 rats and diabetic parental generation presented 116 rats. Of these, the mated nondiabetic female rats were 10 and the number of diabetic rats was 45. In relation to term pregnancy, there were 10 animals in the nondiabetic group and 15 rats in the diabetic group. In the offspring of SD rats (IUGR group), 43 females were classified as small for pregnancy age, 19 rats were classified as appropriate for pregnancy age, and 0 female was classified as large for pregnancy age. The nondiabetic and SD pregnant rats generated offspring with appropriate (control [C]) and small (IUGR) weight for pregnancy age, respectively. At adult life, the C group was maintained as nonexercised C group and IUGR rats were distributed into 2 subgroups, namely, nonexercised (IUGR) and exercised (IUGRex). The rate of mated rats in the IUGR group was reduced compared to the C group. During pregnancy, the IUGR rats presented hyperinsulinemia, impaired reproductive outcomes, decreased body weight, hypertriglyceridemia, and hyperlactacidemia. The IUGRex presented reduced insulin and triglyceride levels. Thus, swimming improved lipid metabolism and increased insulin sensitivity. However, the offspring showed retarded growth, reinforcing the need to stimulate the exercise practice in women under supervision with different professional expertise to promote appropriate gestational conditions and improve perinatal outcomes.
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: S B
authors.initials: SB
authors.lastname: Corvino
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: A O
authors.initials: AO
authors.lastname: Netto
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Y K
authors.initials: YK
authors.lastname: Sinzato
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil Institute of Biological and Health Sciences, University Center of Araguaia, Mato Grosso Federal University, Barra do Garças, Mato Grosso, Brazil.
authors.forename: K E
authors.initials: KE
authors.lastname: Campos
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: I M P
authors.initials: IM
authors.lastname: Calderon
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: M V C
authors.initials: MV
authors.lastname: Rudge
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil Institute of Biological and Health Sciences, University Center of Araguaia, Mato Grosso Federal University, Barra do Garças, Mato Grosso, Brazil.
authors.forename: G T
authors.initials: GT
authors.lastname: Volpato
authors.affiliation: Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador, Zubirán, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Zambrano
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics and Graduate Program on Gynecology, Obstetrics and Mastology, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil damascenofmb@gmail.com.
authors.forename: D C
authors.initials: DC
authors.lastname: Damasceno
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D005865:Gestational Age; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D015228:Hypertriglyceridemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D019344:Lactic Acid / Q000097:blood; D008297:Male; D005082:Physical Exertion; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017208:Rats, Wistar; D012098:Reproduction; D012720:Severity of Illness Index; D013550:Swimming; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D019344:Lactic Acid
keywords: IUGR; diabetes; exercise; pregnancy; rat