title: [Brain structure analysis for patients with antisocial personality disorder by MRI].
abstract: OBJECTIVE
  To investigate the structural abnormalities of brain in patients with antisocial personality disorder (ASPD) but without alcoholism and drug abuse.
  
  
  METHODS
  Volunteers from Hunan Reformatory (n=36) and the matched healthy subjects (n=26) were examined by high-spatial resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Voxel-based morphometry and fractional anisotropy (FA) maps were generated for each subject to reveal structural abnormalities in patients with ASPD.
  
  
  RESULTS
  Compared with the healthy controls, ASPD patients showed significantly higher gray matter volumes in the inferior parietal lobule (P≤0.001, uncorrected), white matter volumes in the precuneus (P≤0.001, uncorrected), FA in the left lingual gyrus, bilateral precuneus, right superior frontal gyrus and right middle temporal gyrus (P≤0.01, uncorrected).
  
  
  CONCLUSIONS
  Our results revealed the abnormal neuroanatomical features in ASPD patients, which might be related to the external behavioral traits in ASPD patients.
authors.affiliation: Department of Radiology, Th ird Xiangya Hospital, Central South University, Changsha 410013; Department of Information Science and Engineering, Hunan First Normal University, Changsha 410205, China.
authors.forename: Weixiong
authors.initials: W
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Liao
authors.forename: Huasheng
authors.initials: H
authors.lastname: Liu
authors.forename: Renzhi
authors.initials: R
authors.lastname: Huang
authors.forename: Yongfan
authors.initials: Y
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D016880:Anisotropy; D000987:Antisocial Personality Disorder / Q000175:diagnosis*; D001921:Brain / Q000033:anatomy & histology*; D016022:Case-Control Studies; D056324:Diffusion Tensor Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging