title: Association between cardiovascular risk factors and carotid intima-media thickness in prepubertal Brazilian children.
abstract: BACKGROUND
  Early exposure to cardiovascular risk factors creates a chronic inflammatory state that could damage the endothelium followed by thickening of the carotid intima-media.
  
  
  OBJECTIVE
  To investigate the association of cardiovascular risk factors and thickening of the carotid intima.
  
  
  METHODS
  Media in prepubertal children. In this cross-sectional study, carotid intima-media thickness (cIMT) and cardiovascular risk factors were assessed in 129 prepubertal children aged from 5 to 10 year. Association was assessed by simple and multivariate logistic regression analyses.
  
  
  RESULTS
  In simple logistic regression analyses, body mass index (BMI) z-score, waist circumference, and systolic blood pressure (SBP) were positively associated with increased left, right, and average cIMT, whereas diastolic blood pressure was positively associated only with increased left and average cIMT (p<0.05). In multivariate logistic regression analyses increased left cIMT was positively associated to BMI z-score and SBP, and increased average cIMT was only positively associated to SBP (p<0.05).
  
  
  CONCLUSIONS
  BMI z-score and SBP were the strongest risk factors for increased cIMT.
authors.forename: Fernanda Mussi
authors.initials: FM
authors.lastname: Gazolla
authors.forename: Maria Alice
authors.initials: MA
authors.lastname: Neves Bordallo
authors.forename: Isabel Rey
authors.initials: IR
authors.lastname: Madeira
authors.forename: Cecilia Noronha
authors.initials: CN
authors.lastname: de Miranda Carvalho
authors.forename: Alexandra Maria
authors.initials: AM
authors.lastname: Vieira Monteiro
authors.forename: Nádia Cristina
authors.initials: NC
authors.lastname: Pinheiro Rodrigues
authors.forename: Marcos Antonio
authors.initials: MA
authors.lastname: Borges
authors.forename: Paulo Ferrez
authors.initials: PF
authors.lastname: Collett-Solberg
authors.forename: Bruna Moreira
authors.initials: BM
authors.lastname: Muniz
authors.forename: Cecilia Lacroix
authors.initials: CL
authors.lastname: de Oliveira
authors.forename: Suellen Martins
authors.initials: SM
authors.lastname: Pinheiro
authors.forename: Rebeca Mathias
authors.initials: RM
authors.lastname: de Queiroz Ribeiro
mesh_terms: D001794:Blood Pressure; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002339:Carotid Arteries / Q000033:anatomy & histology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D011627:Puberty; D012307:Risk Factors; D017539:Tunica Intima / Q000033:anatomy & histology*; D055105:Waist Circumference