title: Trigger chemistries for better industrial formulations.
abstract: In recent years, innovations and consumer demands have led to increasingly complex liquid formulations. These growing complexities have provided industrial players and their customers access to new markets through product differentiation, improved performance, and compatibility/stability with other products. One strategy for enabling more complex formulations is the use of active encapsulation. When encapsulation is employed, strategies are required to effect the release of the active at the desired location and time of action. One particular route that has received significant academic research effort is the employment of triggers to induce active release upon a specific stimulus, though little has translated for industrial use to date. To address emerging industrial formulation needs, in this review, we discuss areas of trigger release chemistries and their applications specifically as relevant to industrial use. We focus the discussion on the use of heat, light, shear, and pH triggers as applied in several model polymeric systems for inducing active release. The goal is that through this review trends will emerge for how technologies can be better developed to maximize their value through industrial adaptation.
authors.affiliation: †Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors.forename: Hsuan-Chin
authors.initials: HC
authors.lastname: Wang
authors.affiliation: ‡Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: †Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Possanza
authors.affiliation: †Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors.forename: Steven C
authors.initials: SC
authors.lastname: Zimmerman
authors.affiliation: ‡Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Cheng
authors.affiliation: †Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.|§Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, United States.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Moore
authors.affiliation: ∥Formulation Science, Corporate Research and Development, The Dow Chemical Company, Midland, Michigan 48667, United States.
authors.forename: Keith
authors.initials: K
authors.lastname: Harris
authors.affiliation: ⊥Formulation Science, Corporate Research and Development, The Dow Chemical Company, Collegeville, Pennsylvania 19426, United States.
authors.forename: Joshua S
authors.initials: JS
authors.lastname: Katz
mesh_terms: D002214:Capsules / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
chemical_list: D002214:Capsules; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: UV-induced; capsule; depolymerization; polymersome; self-assembly; triggered release