title: Long noncoding RNAs: novel players in colorectal cancer.
abstract: Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These lncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment.
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China; Heilongjiang Medical Science Academy, Harbin, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.affiliation: Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China. Electronic address: gaoxu_671227@163.com.
authors.forename: Xu
authors.initials: X
authors.lastname: Gao
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding
keywords: Colorectal cancer (CRC); Long noncoding RNAs; Therapeutic targets; Tumorigenesis