title: Effect of intrauterine infusion of an organic-certified product on uterine health, survival, and fertility of dairy cows with toxic puerperal metritis.
abstract: The objective was to evaluate the effect of intrauterine infusion of an organic certified product (Optimum UterFlush, Van Beek Natural Science, Orange City, IA) on uterine health, survival, and fertility of cows affected with toxic puerperal metritis (TPM) in an organic dairy farm. Cows with TPM were defined as having an abnormally enlarged uterus and a fetid watery red-brown vaginal discharge, associated with systemic illness and fever (rectal temperature ≥39.5°C), within 12 d postpartum. Cows diagnosed with TPM (n=220; study d 0) were blocked by parity (1 and ≥2) and randomly assigned into 1 of 2 intrauterine treatments applied every other day for a total of 3 applications: (1) control (CON)=200mL of povidone iodine diluted in 2L of distilled water (n=113); (2) Optimum UterFlush (UF)=3.75mL diluted in 117mL of distilled water (n=107). All enrolled cows received hypertonic saline solution (500mL 7.2% i.v.), dextrose (500mL 50% i.v.), and oral aspirin (5 boluses/d). Outcome variables for treatment efficacy included fever and presence of fetid vaginal discharge at study d 6 and 14, survival at study d 6 and 14 and at 30 and 100 DIM, and reproductive performance. Control variables were parity, BCS at enrollment, calving season, and milk yield. Occurrence of fever at d 6 and 14 was not different between the 2 treatment groups. Presence of fetid vaginal discharge at d 6 and 14 was lower in cows treated with UF compared with cows in the CON group (10.7 vs. 28% and 1.1 vs. 9.1%). The odds (95% confidence interval) for survival and remaining in the farm at study d 6 and 14 and at 30 and 100 DIM for cows in the UF treatment were 4.67 (1.38-15.8), 2.77 (1.25-6.10), 3.13 (1.22-8.02), and 2.82 (1.38-5.71) times the odds of cows in the CON group, respectively. The odds of AI until 150 DIM and the interval from calving to first AI were not different between the 2 treatments. However, pregnancy was affected by treatment; the odds (95% confidence interval) of pregnancy at the first AI, 150 DIM, and 300 DIM for cows treated with UF were 2.15 (1.05-4.40), 1.81 (1.04-3.15), and 1.92 (1.09-3.38) times the odds of cows in the CON group, respectively. Days to pregnancy were similar in both treatment groups, but the number of artificial inseminations per pregnancy were different (2.69 vs. 2.02 for cows in the CON and UF treatments). Results indicate that cows with TPM administered intrauterine infusion of Optimum UterFlush had higher odds of recovering and improved reproductive performance compared with cows treated with povidone iodine.
authors.affiliation: Texas A&M AgriLife Research & Extension Center, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University System, Amarillo 79106. Electronic address: ppinedo@ag.tamu.edu.
authors.forename: P J
authors.initials: PJ
authors.lastname: Pinedo
authors.affiliation: Aurora Organic Dairy, Platteville, CO 80651-9008.
authors.forename: J S
authors.initials: JS
authors.lastname: Velez
authors.affiliation: Aurora Organic Dairy, Platteville, CO 80651-9008.
authors.forename: H
authors.initials: H
authors.lastname: Bothe
authors.affiliation: Aurora Organic Dairy, Platteville, CO 80651-9008.
authors.forename: D
authors.initials: D
authors.lastname: Merchan
authors.affiliation: Aurora Organic Dairy, Platteville, CO 80651-9008.
authors.forename: J M
authors.initials: JM
authors.lastname: Piñeiro
authors.affiliation: College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
authors.forename: C A
authors.initials: CA
authors.lastname: Risco
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000401:mortality; D000081007:Cymenes; D003612:Dairying / Q000379:methods*; D004716:Endometritis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007315:Insemination, Artificial / Q000662:veterinary; D007774:Lactation; D039821:Monoterpenes / Q000008:administration & dosage*; D058871:Organic Agriculture; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy / Q000662:veterinary*; D012098:Reproduction / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D015996:Survival Rate; D014564:Urogenital Abnormalities; D014591:Uterine Diseases / Q000662:veterinary; D014599:Uterus / Q000002:abnormalities / Q000187:drug effects*; D019522:Vaginal Discharge
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000081007:Cymenes; D039821:Monoterpenes; D012462:Saline Solution, Hypertonic; C073316:carvacrol
keywords: Optimum UterFlush; organic; puerperal metritis