title: Approaches to reducing radiation dose from radionuclide myocardial perfusion imaging.
abstract: Radionuclide myocardial perfusion imaging (MPI) plays a vital role in the evaluation and management of patients with coronary artery disease. However, because of a steep growth in MPI in the mid 2000s, concerns about inappropriate use of MPI and imaging-related radiation exposure increased. In response, the professional societies developed appropriate-use criteria for MPI. Simultaneously, novel technology, image-reconstruction software for traditional scanners, and dedicated cardiac scanners emerged and facilitated the performance of MPI with low-dose and ultra-low-dose radiotracers. This paper provides a practical approach to performing low-radiation-dose MPI using traditional and novel technologies.
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts sdorbala@partners.org.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Dorbala
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Ron
authors.initials: R
authors.lastname: Blankstein
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Hicham
authors.initials: H
authors.lastname: Skali
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Mi-Ae
authors.initials: MA
authors.lastname: Park
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Jolene
authors.initials: J
authors.lastname: Fantony
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Charles
authors.initials: C
authors.lastname: Mauceri
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: James
authors.initials: J
authors.lastname: Semer
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Moore
authors.affiliation: Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, the Noninvasive Cardiovascular Imaging Program, Departments of Medicine (Cardiology) and Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Di Carli
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D018579:Patient Selection; D011786:Quality Control; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods; D011868:Radioisotopes; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D011868:Radioisotopes
keywords: PET; SPECT; low dose; myocardial perfusion imaging; quality assurance; radiation dose