title: Waist-to-Height Ratio and Triglycerides/High-Density Lipoprotein Cholesterol Were the Optimal Predictors of Metabolic Syndrome in Uighur Men and Women in Xinjiang, China.
abstract: OBJECTIVE
  This study aimed to identify the best single predictor of metabolic syndrome by comparing the predictive ability of various anthropometric and atherogenic parameters among a Uighur population in Xinjiang, northwest China.
  
  
  METHODS
  A total of 4767 Uighur participants were selected from the Cardiovascular Risk Survey (CRS), which was carried out from October, 2007, to March, 2010. Anthropometric data, blood pressure, serum concentration of serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and fasting glucose were documented. Prevalence of metabolic syndrome and its individual components were confirmed according to International Diabetes Federation (IDF) criteria. Area under the receiver operating characteristic curve (AUC) of each variable for the presence of metabolic syndrome was compared. The sensitivity (Sen), specificity (Spe), distance in the receiver operating characteristic (ROC) curve, and cutoffs of each variable for the presence of metabolic syndrome were calculated.
  
  
  RESULTS
  In all, 23.7% of men had the metabolic syndrome, whereas 40.1% of women had the metabolic syndrome in a Uighur population in Xinjiang; the prevalence of metabolic syndrome in women was significantly higher than that in men (P<0.001). In men, the waist-to-height ratio (WHtR) had the highest AUC value (AUC=0.838); it was followed by TGs/HDL-C (AUC=0.826), body mass index (BMI) (AUC=0.812), waist-to-hip ratio (WHR) (AUC=0.781), and body adiposity index (BAI) (AUC=0.709). In women, the TGs/HDL-C had the highest AUC value (AUC=0.815); it was followed by WHtR (AUC=0.780), WHR (AUC=0.730), BMI (AUC=0.719), and BAI (AUC=0.699). Similarly, among all five anthropometric and atherogenic parameters, the WHtR had the shortest ROC distance of 0.32 (Sen=85.40%, Spe=71.6%), and the optimal cutoff for WHtR was 0.55 in men. In women, TGs/HDL-C had the shortest ROC distance of 0.35 (Sen=75.29%, Spe=75.18%), and the optimal cutoff of TGs/HDL-C was 1.22.
  
  
  CONCLUSIONS
  WHtR was the best predictor of metabolic syndrome in Uighur men, whereas TGs/HDL-C was the best predictor of metabolic syndrome in Uighur women in Xinjiang.
authors.affiliation: 1 Xinjiang Key Laboratory of Cardiovascular Disease, Clinical Medical Research Institute of First Affiliated Hospital of Xinjiang Medical University , Urumqi, People's Republic of China .
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Shuo
authors.initials: S
authors.lastname: Pan
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: He
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002681:China / Q000208:ethnology; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D008875:Middle Aged; D012372:ROC Curve; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference; D065927:Waist-Height Ratio
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides