title: Effects of different classes of antihypertensive agents on the outcome of acute ischemic stroke.
abstract: It is unclear whether antihypertensive treatment before stroke affects acute ischemic stroke severity and outcome. To evaluate this association, the authors studied 482 consecutive patients (age 78.8±6.7 years) admitted with acute ischemic stroke. Stroke severity was assessed at admission with the National Institutes of Health Stroke Scale (NIHSS). The outcome was assessed with rates of adverse outcome (modified Rankin scale at discharge ≥2). Independent predictors of severe stroke (NIHSS ≥16) were female sex and atrial fibrillation. Treatment with diuretics before stroke was associated with nonsevere stroke. At discharge, patients with adverse outcome were less likely to be treated before stroke with β-blockers or with diuretics. Independent predictors of adverse outcome were older age, higher NIHSS at admission, and history of ischemic stroke. Treatment with diuretics before stroke appears to be associated with less severe neurologic deficit in patients with acute ischemic stroke.
authors.affiliation: First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Tziomalos
authors.forename: Vasilios
authors.initials: V
authors.lastname: Giampatzis
authors.forename: Stella D
authors.initials: SD
authors.lastname: Bouziana
authors.forename: Marianna
authors.initials: M
authors.lastname: Spanou
authors.forename: Maria
authors.initials: M
authors.lastname: Papadopoulou
authors.forename: Pavlina
authors.initials: P
authors.lastname: Kazantzidou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Kostaki
authors.forename: Antonios
authors.initials: A
authors.lastname: Kouparanis
authors.forename: Christos
authors.initials: C
authors.lastname: Savopoulos
authors.forename: Apostolos I
authors.initials: AI
authors.lastname: Hatzitolios
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index; D020521:Stroke / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents