title: A reusable microRNA sensor based on the electrocatalytic property of heteroduplex-templated copper nanoclusters.
abstract: DNA-RNA heteroduplexes have been used as templates for copper nanocluster (CuNC) formation for the first time. Taking advantage of the electrocatalysis of CuNCs, quantitation of miRNA can thus be accomplished. More importantly, by simply operating several rounds of CuNC formation, repeated detection of miRNA has further been realized, which is rare in miRNA biosensors.
authors.affiliation: Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials and Jiangsu key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, P. R. China. daizhihuii@ninu.edu.cn.
authors.forename: Zhaoyin
authors.initials: Z
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Si
authors.forename: Jianchun
authors.initials: J
authors.lastname: Bao
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Dai
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D004563:Electrochemistry; D017743:Equipment Reuse; D053768:Metal Nanoparticles / Q000737:chemistry*; D035683:MicroRNAs / Q000032:analysis* / Q000737:chemistry; D008958:Models, Molecular; D009690:Nucleic Acid Conformation
chemical_list: D035683:MicroRNAs; D003300:Copper; D004247:DNA