title: Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible.
abstract: Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.
authors.affiliation: Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Republic of Korea.
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Hwang
authors.affiliation: Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Republic of Korea.
authors.forename: Sang-Sun
authors.initials: SS
authors.lastname: Han
authors.affiliation: Department of Dental Hygiene, Kyungpook National University, Sangju, Republic of Korea.
authors.forename: Ki-Rim
authors.initials: KR
authors.lastname: Kim
authors.affiliation: Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam, Republic of Korea.
authors.forename: Lee
authors.initials: L
authors.lastname: Ye-Jin
authors.affiliation: Oral Cancer Research Institute, Department of Oral Biology, and BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Lee
authors.initials: L
authors.lastname: Sun-Kyung
authors.affiliation: Oral Cancer Research Institute, Department of Oral Biology, and BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Park
authors.initials: P
authors.lastname: Kwang-Kyun
authors.affiliation: Oral Cancer Research Institute, Department of Oral Biology, and BK21 PLUS Project, Yonsei University College of Dentistry, Seoul, Republic of Korea.
authors.forename: Chung
authors.initials: C
authors.lastname: Won-Yoon
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000556:secondary*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007273:Injections, Intramuscular; D008156:Luciferases; D008163:Luminescent Measurements; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008807:Mice, Inbred BALB C; D015203:Reproducibility of Results; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D008156:Luciferases