title: Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome.
abstract: BACKGROUND
  Polycystic ovarian syndrome (PCOS) is characterized by irregular menses, elevated androgens, and insulin resistance. Little information is published about the treatment of adolescent PCOS.
  
  
  OBJECTIVE
  The aim of this study was to evaluate metformin versus oral contraceptive pills (OCP) in treating adolescent PCOS. Twenty-two girls were randomized to either treatment for 6 months. The outcomes variables included body mass index (BMI) and free testosterone (FT).
  
  
  RESULTS
  BMI decreased in all patients (metformin p=0.004, OCP p=0.045). FT decreased significantly only with OCP. Insulin resistance measures decreased in all patients but did not reach significance. The only significant difference in any of the variables between the two groups was number of menses. BMI and FT remained less than baseline for 3 months off treatment.
  
  
  CONCLUSIONS
  Metformin and OCP have a positive effect on BMI, which persists after treatment is discontinued. FT decreased with both treatments, but only reached significance with OCP.
authors.forename: Hiba
authors.initials: H
authors.lastname: Al-Zubeidi
authors.forename: Karen O
authors.initials: KO
authors.lastname: Klein
mesh_terms: D000293:Adolescent; D000728:Androgens / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002853:Chromatography, Liquid; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D008599:Menstruation Disturbances / Q000503:physiopathology*; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D053719:Tandem Mass Spectrometry; D013739:Testosterone / Q000097:blood
chemical_list: D000728:Androgens; D003277:Contraceptives, Oral, Combined; D007004:Hypoglycemic Agents; D013739:Testosterone; D008687:Metformin