title: Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer.
abstract: Long noncoding RNAs (lncRNAs) are longer than 200-nucleotide, noncoding transcripts in length, have a variety of biological functions, and are closely associated with tumor development. Ovarian cancer, as 1 of the 3 common gynecological malignancies, is the leading cause of death in women with gynecological malignant tumor. In this study, a review of the literature found that lncRNAs H19, LSINCT5, and XIST have a close relationship to the development of ovarian cancer occurrence, growth, invasion, and metastasis, and they can promote ovarian cancer cell proliferation. Hence, in this article, the progress of above-mentioned 3 kinds of lncRNAs in ovarian cancer was reviewed and designed to help in the diagnosis, treatment, and prognosis of ovarian cancer.
authors.affiliation: *Harbin Medical University, Harbin, China; †The First Affiliated Hospital of Harbin Medical University, Harbin, China; ‡The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China; and §Inner Mongolia Medical College, Hohhot, China.
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Ren
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Tianzhen
authors.initials: T
authors.lastname: Wang
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.forename: Ci
authors.initials: C
authors.lastname: Zhao
authors.forename: Tian
authors.initials: T
authors.lastname: Liang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhu
authors.forename: Minghui
authors.initials: M
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guang-mei
authors.initials: GM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding