title: CREB1 gene polymorphisms combined with environmental risk factors increase susceptibility to major depressive disorder (MDD).
abstract: Major depressive disorder (MDD) is one of the most severe psychiatric disorders. The objective of this study was to explore the effects of CREB1 gene polymorphisms on risk of developing MDD and the joint effects of gene-environment interactions. Genotyping was performed by Taqman allelic discrimination assay among 586 patients and 586 healthy controls. A significant impact on rs6740584 genotype distribution was found for childhood trauma (P = 0.015). We did not find an association of CREB1 polymorphisms with MDD susceptibility. However, we found a significantly increased risk associated with the interactions of CREB1 polymorphisms and drinking (OR = 11.67, 95% CI = 2.52-54.18; OR = 11.52, 95% CI = 2.55-51.95 for rs11904814; OR = 4.18, 95% CI = 1.87-9.38; OR = 5.02, 95% CI = 2.27-11.14 for rs6740584; OR = 7.58, 95% CI = 2.05-27.98; OR = 7.59, 95% CI = 2.12-27.14 for rs2553206; OR = 8.37, 95% CI = 3.02-23.23; OR = 7.84, 95% CI = 2.93-20.98 for rs2551941). We also noted that CREB polymorphisms combined with family harmony and childhood trauma conferred increased susceptibility for MDD. In conclusion, polymorphisms in the CREB gene may not be independently associated with MDD risk, but they are likely to confer increased susceptibility by interacting with environmental risk factors in the Chinese population.
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Xiuxian
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Zhengxue
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Medical Psychological Institute, Second Xiangya Hospital, Central South University Changsha, Hunan, China.
authors.forename: Xiongzhao
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Sui
authors.affiliation: Department of Psychology, Public Health Institute, Harbin Medical University 157 Baojian Road, Nangang, Harbin 150081, China.
authors.forename: Jingsong
authors.initials: J
authors.lastname: Ma
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics / Q000523:psychology; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013315:Stress, Psychological / Q000150:complications
chemical_list: C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein
keywords: CREB1; MDD; Polymorphism; environmental risk factors; susceptibility