title: Local sustained-release delivery systems of the antibiofilm agent thiazolidinedione-8 for prevention of catheter-associated urinary tract infections.
abstract: Thiazolidinedione-8 (TZD-8) is an anti-quorum-sensing molecule that has the potential to effectively prevent catheter-associated urinary tract infections, a major healthcare challenge. Sustained-release drug-delivery systems can enhance drugs' therapeutic potential, by maintaining their therapeutic level and reducing their side effects. Varnishes for sustained release of TZD-8 based on ethylcellulose or ammonio methacrylate copolymer type A (Eudragit(®) RL) were developed. The main factors affecting release rate were found to be film thickness and presence of a hydrophilic or swellable polymer in the matrix. The release mechanism of ethylcellulose-based systems matched the Higuchi model. Selected varnishes were retained on catheters for at least 8 days. Sustained-release delivery systems of TZD-8 were active against Candida albicans biofilms. The present study demonstrates promising results en route to developing applications for the prevention of catheter-associated infections.
authors.affiliation: Department of Pharmaceutics, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel. Electronic address: julia.shenderovic@mail.huji.ac.il.
authors.forename: Julia
authors.initials: J
authors.lastname: Shenderovich
authors.affiliation: Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, P.O.B 12272, Jerusalem 91120, Israel.
authors.forename: Mark
authors.initials: M
authors.lastname: Feldman
authors.affiliation: Department of Pharmaceutics, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Kirmayer
authors.affiliation: Department of Pharmaceutics, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel; Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, P.O.B 12272, Jerusalem 91120, Israel.
authors.forename: Abed
authors.initials: A
authors.lastname: Al-Quntar
authors.affiliation: Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, P.O.B 12272, Jerusalem 91120, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Steinberg
authors.affiliation: Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O.B. 12, Rehovot 76100, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Lavy
authors.affiliation: Department of Pharmaceutics, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, P.O.B 12065, Jerusalem 91120, Israel.
authors.forename: Michael
authors.initials: M
authors.lastname: Friedman
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D055499:Catheter-Related Infections / Q000382:microbiology / Q000517:prevention & control*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007700:Kinetics; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D045162:Thiazolidinediones / Q000008:administration & dosage* / Q000737:chemistry; D014546:Urinary Catheterization / Q000009:adverse effects* / Q000295:instrumentation*; D062885:Urinary Catheters / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D045162:Thiazolidinediones; C000604031:thiazolidinedione-8; C058665:Eudragit RL; C013517:ethyl cellulose; D002482:Cellulose
keywords: Catheter-associated infections; Modeling; Quorum sensing; Sustained release; Thiazolidinedione-8; Varnish