title: Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening.
abstract: OBJECTIVE
  To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.
  
  
  METHODS
  We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer. All patients were divided into two groups: a magnifying narrow band imaging group, and a lugol chromoendoscopy group, for comparison of adverse symptoms. Esophageal cancer screening was performed on withdrawal of the endoscope. The primary endpoint was a score on a visual analogue scale for heartburn after the examination. The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations, change in vital signs, total procedure time, and esophageal observation time.
  
  
  RESULTS
  The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group (P = 0.004, 0.024, respectively, ANOVA for repeated measures). The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group. There was no significant difference between the two groups with respect to other vital sign. The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group (450 ± 116 vs 565 ± 174, P = 0.004, 44 ± 26 vs 151 ± 72, P < 0.001, respectively).
  
  
  CONCLUSIONS
  Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy. Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically.
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Ryuta
authors.initials: R
authors.lastname: Takenaka
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hori
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Takemoto
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Kawahara
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Shigeatsu
authors.initials: S
authors.lastname: Fujiki
authors.affiliation: Yasushi Yamasaki, Ryuta Takenaka, Koji Takemoto, Shigeatsu Fujiki, Department of Gastroenterology, Tsuyama Chuo Hospital, Tsuyama, Okayama 708-0841, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001706:Biopsy; D002637:Chest Pain / Q000209:etiology; D004396:Coloring Agents / Q000009:adverse effects; D055088:Early Detection of Cancer / Q000009:adverse effects / Q000379:methods*; D004938:Esophageal Neoplasms / Q000473:pathology*; D004945:Esophagoscopy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006356:Heartburn / Q000209:etiology; D006801:Humans; D007454:Iodides / Q000009:adverse effects; D007564:Japan; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000009:adverse effects; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D004396:Coloring Agents; D007454:Iodides; C010389:Lugol's solution
keywords: Adverse symptoms; Lugol; Narrow band imaging; Tolerability; Visual analogue scale score