title: [Evolution of mechanisms of Ca(2+)-signaling. Role of Ca2+ in regulation of specialized functions of cardiomyocytes in chronic heart diseases].
abstract: The review considers role of Ca2+ ions in regulation of specialized functions of cardiomyocytes (CM) in disturbances of heart activity. Problems of Ca(2+)-dependent signaling mechanisms leading to pathological hypertrophy, arrythmogenesis, and heart failure are elucidated. A particular attention is paid to analysis of Ca(2+)-dependent molecular mechanisms leading to remodeling of contractile proteins, apoptosis, or pathological growth of CM.
authors.forename: I V
authors.initials: IV
authors.lastname: Shemarova
authors.forename: V P
authors.initials: VP
authors.lastname: Nesterov
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D003285:Contractile Proteins / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000502:physiology
chemical_list: D003285:Contractile Proteins