title: Effect on Liver Enzymes of Biliopancreatic Diversion: 4 Years of Follow-Up.
abstract: BACKGROUND
  Elevated serum aminotransferase levels are commonly associated with obesity and with a progression to chronic liver disease. Bariatric surgery is the most effective strategy to achieve weight loss.
  
  
  METHODS
  We conducted the present study with the aim of evaluating the influence of biliopancreatic diversion (BPD) on liver enzymes levels during 4 years in morbid obese patients with normal aminotransferase (n = 65) and in morbid obese patients with high aminotransferase basal levels (n = 50).
  
  
  RESULTS
  A decrease in alanine aminotransferase and aspartate aminotransferase activities was significant after biliopancreatic diversion. The basal percentage of high aminotransferase levels and percentage of ratio ALT/AST <1 also decreased significantly at 1-, 2-, 3- and 4-years of follow-up in both groups. ALT (52 to 20%), AST (42 to 10%) and ALT/AST (80 to 22%) in patients with normal aminotransferase. ALT (82 to 20%), AST (70 to 6%) and ALT/AST (90 to 20%) in patients with elevated transaminase basal levels. Bariatric surgery was associated with a significant and sustained decrease in body weight in both groups. Serum trasnaminases level changes were positively correlated to body weight changes during follow-up.
  
  
  CONCLUSIONS
  BPD is an effective method of achieving sustainable weight loss and reduced aminotransferase levels and enzyme ratios of liver damage.
authors.forename: Rocio
authors.initials: R
authors.lastname: Aller
authors.forename: David
authors.initials: D
authors.lastname: Pacheco
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.forename: David
authors.initials: D
authors.lastname: Primo
authors.forename: Daniel A
authors.initials: DA
authors.lastname: de Luis
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D015904:Biliopancreatic Diversion; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000201:enzymology / Q000517:prevention & control; D009767:Obesity, Morbid / Q000201:enzymology / Q000601:surgery*; D015431:Weight Loss
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase