title: Evaluation of intra-aneurysmal hemodynamics after flow diverter placement in a patient-specific aneurysm model.
abstract: BACKGROUND
  The growth and rupture of cerebral aneurysms is intrinsically related to the hemodynamics prevailing in the diseased area. Therefore, a better understanding of intra-aneurysmal hemodynamics is essential for developing effective treatment methods.
  
  
  OBJECTIVE
  The intention of this study was to evaluate the intra-aneurysmal flow and flow reduction induced by flow diverters in a true-to-scale elastic aneurysm model, obtained from real patient data.
  
  
  METHODS
  Based on the computed tomography angiography (CTA) data of a fusiform aneurysm of a 34 year old patient, an elastic silicon rubber model of the aneurysm was produced. A physiologic pulsatile flow was created with a circulatory experimental set-up, and a non-Newtonian perfusion fluid was used as a substitute for human blood. Hemodynamics were measured by LDA before and after flow diverter implantation.
  
  
  RESULTS
  Implantation of a flow diverter device resulted in a reduction of intra-aneurysmal maximum flow velocities of 97.8% at the inflow zone, 89.1% in the dome and 89.3% at the outflow zone, when compared to the native model. A significant reduction of 94% in the mean intra-aneurysmal velocity was found.
  
  
  CONCLUSIONS
  This promising methodology can optimize patient treatment and will correlate with computational simulations to evaluate their reliability.
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Balasso
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Bauer
authors.affiliation: Department of Neuroradiology, Uniklinik Köln, Köln, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Liebig
authors.affiliation: Department of Neuroradiology, Uniklinik Köln, Köln, Germany.
authors.forename: Franziska
authors.initials: F
authors.lastname: Dorn
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Zimmer
authors.affiliation: Munich University of Applied Sciences, Munich, Germany.
authors.forename: Dieter
authors.initials: D
authors.lastname: Liepsch
authors.affiliation: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Sascha
authors.initials: S
authors.lastname: Prothmann
mesh_terms: D001783:Blood Flow Velocity; D002533:Cerebral Angiography; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008955:Models, Cardiovascular; D015607:Stents; D014057:Tomography, X-Ray Computed
keywords: Stent; endovascular; flow diversion; laser Doppler anemometry; non-Newtonian fluid