title: One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol.
abstract: Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany. marcelo.calderon@fu-berlin.de.
authors.forename: Ana
authors.initials: A
authors.lastname: Sousa-Herves
authors.forename: Stefanie
authors.initials: S
authors.lastname: Wedepohl
authors.forename: Marcelo
authors.initials: M
authors.lastname: Calderón
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005990:Glycerol / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; C043941:polyglycerol; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine; D005990:Glycerol