title: Use of Dual-Source Computed Tomography to Evaluate Renal Cortical Perfusion in Patients With Essential Hypertension Without Diabetes: Preliminary Results.
abstract: OBJECTIVE
  To assess renal cortical perfusion parameter changes using computed tomography (CT) renal perfusion examination in patients with essential hypertension (EH), especially those with EH-related target organ damage (TOD), and to correlate renal perfusion parameters with clinical and laboratory data.
  
  
  METHODS
  Consecutive patients with EH (without exclusion criteria) and healthy controls underwent 128-slice dual-source CT perfusion imaging. Quantitative perfusion analysis of renal cortex parameters [blood flow (BF), blood volume, time to peak, and mean transit time] was performed.
  
  
  RESULTS
  Ninety-one participants (60 patients with EH, 31 healthy controls) underwent renal perfusion CT imaging, and 84 participants (92.3%) were eligible for perfusion analysis. The BF values were lower in patients with EH than that in controls. Blood flow was correlated with age (P < 0.01), duration of hypertension (P < 0.01), estimated glomerular filtration rate (eGFR; P < 0.01), pulse pressure (P < 0.05), and body mass index (BMI; P < 0.05). Duration of hypertension, eGFR, and BMI were independently associated with BF. No parameter differed between control subjects and those with EH but not. Blood flow was lower in patients with TOD than in control subjects (P < 0.01), but no other parameter differed. Blood flow was lower (P < 0.01) and mean transit time and time to peak were higher (P < 0.05) in the TOD than that in the non-TOD group.
  
  
  CONCLUSIONS
  Essential hypertension, especially EH-related TOD, alters renal cortical perfusion parameters, especially BF. Four-dimensional spiral CT renal perfusion examination showed that duration of hypertension, eGFR, and BMI were independently associated with decreased BF.
authors.affiliation: From the Departments of *Cardiovascular Radiology and †Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Chong-fu
authors.initials: CF
authors.lastname: Jia
authors.forename: Zhao-qian
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Xi-xia
authors.initials: XX
authors.lastname: Sun
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Yang
authors.forename: Yun-peng
authors.initials: YP
authors.lastname: Cheng
authors.forename: Yi-nong
authors.initials: YN
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015897:Comorbidity; D003287:Contrast Media; D003920:Diabetes Mellitus / Q000453:epidemiology; D000075222:Essential Hypertension; D005260:Female; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D007472:Iohexol / Q000031:analogs & derivatives; D007672:Kidney Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D055815:Young Adult
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide