title: Impact of 10-valent pneumococcal conjugate vaccine on pneumococcal meningitis in children up to two years of age in Brazil.
abstract: The objective of this study was to analyze the impact of vaccination against Streptococcus pneumoniae on the morbidity and mortality from pneumococcal meningitis in children ≤ 2 years in Brazil, from 2007 to 2012. This is a descriptive study and ecological analysis using data from the Information System on Notifiable Diseases. Pre-vaccination (2007-2009) and post-vaccination (2011-2012) periods were defined to compare incidence rates and mortality. A total of 1,311 cases and 430 deaths were reported during the study period. Incidence decreased from 3.70/100,000 in 2007 to 1.84/100,000 in 2012, and mortality decreased from 1.30/100,000 to 0.40/100,000, or 50% and 69% respectively, with the greatest impact in the 6-11 month age group. This decrease in Pneumococcal meningitis morbidity and mortality rates two years after introduction of the 10-valent pneumococcal conjugate vaccine suggests its effectiveness.
authors.forename: Indianara Maria
authors.initials: IM
authors.lastname: Grando
authors.forename: Camile de
authors.initials: Cd
authors.lastname: Moraes
authors.forename: Brendan
authors.initials: B
authors.lastname: Flannery
authors.forename: Walter Massa
authors.initials: WM
authors.lastname: Ramalho
authors.forename: Marco Aurélio P
authors.initials: MA
authors.lastname: Horta
authors.forename: Diana Lucia Moura
authors.initials: DL
authors.lastname: Pinho
authors.forename: Gilmara Lima
authors.initials: GL
authors.lastname: Nascimento
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008586:Meningitis, Pneumococcal / Q000453:epidemiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination
chemical_list: C586648:10-valent pneumococcal conjugate vaccine; D022242:Pneumococcal Vaccines