title: Comparison of intraplatelet reactive oxygen species, mitochondrial damage, and platelet apoptosis after implantation of three continuous flow left ventricular assist devices: HeartMate II, Jarvik 2000, and HeartWare.
abstract: Differences in device design may have an effect on platelet damage and associated clinical complications. We aimed to compare device-specific platelet functionality in 26 heart failure patients supported with three continuous-flow left ventricular assist devices: HeartMate II (n = 8), Jarvik 2000 (n = 9), and HeartWare (n = 9). Intraplatelet reactive oxygen species (ROS) generation, mitochondrial damage, and platelet apoptosis were compared between device types before and after the implantation at every week up to 1 month. Overall, the baseline characteristics, demographics, routine laboratory values were comparable between the three device groups. Intraplatelet ROS, mitochondrial damage, and platelet apoptosis significantly elevated in the HeartWare group in comparison with the other two device groups after implantation. The major bleeding, infections, systemic inflammatory response syndrome, and right ventricular failure were found to be more common among the HeartWare group than others. Intraplatelet ROS and platelet damage levels were returned to baseline in both the HeartMate II and the Jarvik groups, whereas in HeartWare group they remained elevated. The patients with the Jarvik and the HeartMate II experienced less clinical complications and the platelet functionality is not compromised by these devices. Data from this study suggests that the continuous-flow left ventricular assist devices design may exert different effects on platelet function.
authors.affiliation: From the *Department of Surgery, Artificial Organs Laboratory, University of Maryland School of Medicine, Baltimore, Maryland; †Department of Clinical Engineering, University of Maryland Medical Center, Baltimore, Maryland; and ‡Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Nandan K
authors.initials: NK
authors.lastname: Mondal
authors.forename: Erik N
authors.initials: EN
authors.lastname: Sorensen
authors.forename: Erika D
authors.initials: ED
authors.lastname: Feller
authors.forename: Si M
authors.initials: SM
authors.lastname: Pham
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.forename: Zhongjun J
authors.initials: ZJ
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis; D001792:Blood Platelets / Q000473:pathology*; D005260:Female; D005434:Flow Cytometry; D006333:Heart Failure / Q000601:surgery; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D008928:Mitochondria / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017382:Reactive Oxygen Species