title: Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Guidelines from the American Society for Blood and Marrow Transplantation.
abstract: Therapeutic strategies for multiple myeloma (MM) have changed dramatically over the past decade. Thus, the role of hematopoietic stem cell transplantation (HCT) must be considered in the context of this evolution. In this evidence-based review, we have critically analyzed the data from the most recent clinical trials to better understand how to incorporate HCT and when HCT is indicated. We have provided our recommendations based on strength of evidence with the knowledge that ongoing clinical trials make this a dynamic field. Within this document, we discuss the decision to proceed with autologous HCT, factors to consider before proceeding to HCT, the role of tandem autologous HCT, post-HCT maintenance therapy, and the role of allogeneic HCT for patients with MM.
authors.affiliation: MD Anderson Cancer Center, Houston, Texas. Electronic address: nshah@mdanderson.org.
authors.forename: Nina
authors.initials: N
authors.lastname: Shah
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
authors.forename: Natalie
authors.initials: N
authors.lastname: Callander
authors.affiliation: University of Kansas Medical Center, Kansas City, Kansas.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: University of Kentucky, Lexington, Kentucky.
authors.forename: Zartash
authors.initials: Z
authors.lastname: Gul
authors.affiliation: Center for International Blood and Marrow Transplant Research and Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hamadani
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Luciano
authors.initials: L
authors.lastname: Costa
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennesee.
authors.forename: Salyka
authors.initials: S
authors.lastname: Sengsayadeth
authors.affiliation: Spectrum Health, Grand Rapids, Michigan.
authors.forename: Muneer
authors.initials: M
authors.lastname: Abidi
authors.affiliation: Center for International Blood and Marrow Transplant Research and Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Parameswaran
authors.initials: P
authors.lastname: Hari
authors.affiliation: Hopital Saint-Antoine, APHP, Paris, France; Université Pierre & Marie Curie, Paris, France, INSERM, UMRs 938, Paris, France.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.affiliation: Massachusetts General Hospital Cancer Center, Boston, Massachusetts.
authors.forename: Yi-Bin
authors.initials: YB
authors.lastname: Chen
authors.affiliation: Dana-Farber Cancer Institute, Boston, Massachusetts.
authors.forename: John
authors.initials: J
authors.lastname: Koreth
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Heather
authors.initials: H
authors.lastname: Landau
authors.affiliation: Case Western Reserve University, Cleveland, Ohio.
authors.forename: Hillard
authors.initials: H
authors.lastname: Lazarus
authors.affiliation: HLL Communications, Gainesville, Florida.
authors.forename: Helen
authors.initials: H
authors.lastname: Leather
authors.affiliation: Cleveland Clinic, Cleveland, Ohio.
authors.forename: Navneet
authors.initials: N
authors.lastname: Majhail
authors.affiliation: University of Massachusetts, Worcester, Massachusetts.
authors.forename: Rajneesh
authors.initials: R
authors.lastname: Nath
authors.affiliation: Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Keren
authors.initials: K
authors.lastname: Osman
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Miguel-Angel
authors.initials: MA
authors.lastname: Perales
authors.affiliation: Cancer Transplant Institute at Scottsdale Healthcare, Scottsdale, Arizona.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Schriber
authors.affiliation: Texas Transplant Institute, San Antonio, Texas.
authors.forename: Paul
authors.initials: P
authors.lastname: Shaughnessy
authors.affiliation: John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey.
authors.forename: David
authors.initials: D
authors.lastname: Vesole
authors.affiliation: Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Ravi
authors.initials: R
authors.lastname: Vij
authors.affiliation: University of Florida College of Medicine, Gainesville, Florida.
authors.forename: John
authors.initials: J
authors.lastname: Wingard
authors.affiliation: Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennesee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
mesh_terms: D000367:Age Factors; D002869:Chromosome Aberrations; D019468:Disease Management; D019317:Evidence-Based Medicine; D005720:Gamma Rays / Q000627:therapeutic use*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D019653:Myeloablative Agonists
keywords: Guidelines; Multiple myeloma; Recommendations; Transplantation