title: Effect of borneol, moschus, storax, and acorus tatarinowii on expression levels of four amino acid neurotransmitters in the rat corpus striatum.
abstract: The present study collected cerebrospinal fluid samples from the corpus striatum in rats treated with borneol, moschus, storax, and acorus tatarinowii using brain microdialysis technology. Levels of excitatory neurotransmitters aspartic acid and glutamate, as well as inhibitory neurotransmitters glycine and γ-aminobutyric acid, were measured in samples using reversed-phase high-performance liquid chromatography, phosphate gradient elution, and fluorescence detection. Results showed that concentrations of all four amino acid neurotransmitters significantly increased in the corpus striatum following treatment with borneol or moschus, but effects due to borneol were more significant than moschus. Acorus tatarinowii treatment increased γ-aminobutyric acid expression, but decreased glutamate concentrations. Storax increased aspartic acid concentrations and decreased glycine expression. Results demonstrated that borneol and moschus exhibited significant effects on con amino acid neurotransmitter expression; storax exhibited excitatory effects, and acorus tatarinowii resulted in inhibitory effects.
authors.affiliation: Pharmacy of Traditional Chinese Medicine, Drugs Supply Centre of PLA General Hospital, Beijing 100853, China ; Department of Pharmacy, Shijiazhuang Fourth Hospital, Shijiazhuang 050011, Hebei Province, China.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Pharmacy of Traditional Chinese Medicine, Drugs Supply Centre of PLA General Hospital, Beijing 100853, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Pharmacy of Traditional Chinese Medicine, Drugs Supply Centre of PLA General Hospital, Beijing 100853, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: He
keywords: acorus tatarinowii; amino acid; borneol; high-performance liquid chromatography; microdialysis; moschus; neurotransmitter; resuscitation drugs; storax