title: 7, 8-dihydroxycoumarin improves neurological function in a mouse model of sciatic nerve injury.
abstract: In the present study, a mouse model of sciatic nerve injury was treated with intraperitoneal injection of 7, 8-dihydroxycoumarin (10, 5, or 2.5 mg/kg per day). Western blot and real-time PCR results showed that growth associated protein 43 expression was significantly increased in the L4-6 segments of the spinal cord. The amplitude and velocity of motor nerve conduction in the sciatic nerve were significantly increased in model mice. In addition, the appearance of the myelin sheath in the injured sciatic nerve was regular, with an even thickness and clear outline, and the surrounding fibroplasia was not obvious. Our results indicate that 7, 8-dihydroxycoumarin can promote the repair of injured nerve by upregulating growth associated protein 43 expression in the corresponding spinal cord segments of mice with sciatic nerve injury.
authors.affiliation: Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Jianshi
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Yingli
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130033, Jilin Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
keywords: 7; 8-dihydroxycoumarin; growth associated protein 43; neural regeneration; peripheral nerve injury; sciatic nerve