title: The role of high-density lipoproteins in the regulation of angiogenesis.
abstract: Angiogenesis is important for postnatal physiological processes including tissue neovascularization in response to an ischaemic injury. Conversely, uncontrolled inflammatory-driven angiogenesis can accelerate atherosclerotic plaque and tumour growth. Angiogenesis-associated diseases are highly prevalent globally, with cardiovascular-related disorders and cancer being the leading causes of mortality worldwide. A vast amount of research has been conducted on the vasculoprotective effects of high-density lipoproteins (HDLs) and while current HDL-raising therapies to date have not yielded the desired benefits clinically, its role in angiogenesis is yet to be fully elucidated. Epidemiological studies report positive correlations between elevated HDL levels and improved prognosis in both ischaemia- and inflammatory-driven pathologies, in which angiogenesis plays a key role. This review focuses on current evidence from epidemiological and prospective studies, coupled with animal models and mechanistic studies that highlight the ability of HDL to conditionally regulate angiogenesis.
authors.affiliation: The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia Sydney Medical School, University of Sydney, Sydney, Australia.
authors.forename: Joanne T M
authors.initials: JT
authors.lastname: Tan
authors.affiliation: The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia Sydney Medical School, University of Sydney, Sydney, Australia Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
authors.forename: Martin K C
authors.initials: MK
authors.lastname: Ng
authors.affiliation: The Heart Research Institute, 7 Eliza Street, Newtown, Sydney, New South Wales 2042, Australia Sydney Medical School, University of Sydney, Sydney, Australia bursillc@hri.org.au.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Bursill
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D043925:Angiogenesis Inducing Agents; D008075:Lipoproteins, HDL
keywords: Angiogenesis; High-density lipoprotein; Inflammation; Ischaemia