title: Wolf's Isotopic Response: Varicella Within a Prior Immunization Reaction Site.
abstract: Wolf's isotopic response describes the occurrence of a dermatologic condition at the site of a prior healed unrelated condition. Our report details a case of varicella occurring as a secondary condition at the site of a prior immunization reaction; herpesvirus infection has not been reported as a secondary condition in cases of Wolf's isotopic response before. Current hypotheses favor the involvement of neurohormonal modulation of local immunity in response to various forms of injury as a model for explaining these phenomena.
authors.affiliation: School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Sam
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Diana B
authors.initials: DB
authors.lastname: McShane
authors.affiliation: Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Craig N
authors.initials: CN
authors.lastname: Burkhart
authors.affiliation: Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
authors.forename: Dean S
authors.initials: DS
authors.lastname: Morrell
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002644:Chickenpox / Q000175:diagnosis* / Q000188:drug therapy; D003875:Drug Eruptions / Q000276:immunology*; D006801:Humans; D007114:Immunization / Q000009:adverse effects*; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D012871:Skin Diseases / Q000276:immunology*; D013848:Thigh
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir