title: [The influence of uranyl in nanomolar concentrations on erythrocyte sensitivity (in vitro) to factors inducing acute oxidative stress].
abstract: The influence of nanomolar concentrations of UO2Cl2 on the erythrocyte sensitivity (in vitro) to the factors inducing acute oxidative stress was investigated. It was shown that even a short-run exposure of uranyl ions resulted in the changes of the physico-chemical properties of the membrane. It can affectnot only the survival of cells but significantly modify their reaction on the effect of damaging factors, particularly on the impact of oxidative stress inductors. The character of modification depends on a radical source and results from the mechanisms of their effects on the cell and the ability of uranyl to catalyze ROS-forming processes. The detailed investigation into the mechanisms of the effect of uranyl ions at low concentration on cells is required.
authors.forename: O G
authors.initials: OG
authors.lastname: Shevchenko
mesh_terms: D000578:Amidines / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D002712:Chlorides / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D006461:Hemolysis / Q000187:drug effects / Q000528:radiation effects; D006861:Hydrogen Peroxide / Q000494:pharmacology; D051379:Mice; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D014501:Uranium / Q000494:pharmacology*
chemical_list: D000578:Amidines; D002712:Chlorides; D016877:Oxidants; D014501:Uranium; C046728:2,2'-azobis(2-amidinopropane); D006861:Hydrogen Peroxide; C408075:uranyl chloride