title: [Effectiveness of pharmacotherapy of irritated bowel syndrome from the standpoint of evidence based medicine].
abstract: Evaluation of the action of various medicines used to treat irritated bowel syndrome from the standpoint of evidence based medicine indicates that most of them (spasmolytics, probiotics, loperamide, aperients) show but low effectiveness. The use of more efficacious preparations (alosterone, cisapride, tegacerode) is associated with serious adverse reactions whereas prucalopride is applied for unregistered indications. It necessitates the development of new drugs with enhanced effectiveness and tolerability.
authors.forename: A A
authors.initials: AA
authors.lastname: Sheptulin
authors.forename: M A
authors.initials: MA
authors.lastname: Vize-Khripunova
mesh_terms: D002986:Clinical Trials as Topic; D003248:Constipation / Q000188:drug therapy* / Q000209:etiology; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D019317:Evidence-Based Medicine; D005765:Gastrointestinal Agents / Q000145:classification / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D015201:Meta-Analysis as Topic; D017063:Outcome Assessment, Health Care
chemical_list: D005765:Gastrointestinal Agents