title: Role for radiation therapy in melanoma.
abstract: Although melanoma is generally considered a relative radioresistant tumor, radiation therapy (RT) remains a valid and effective treatment option in definitive, adjuvant, and palliative settings. Definitive RT is generally only used in inoperable patients. Despite a high-quality clinical trial showing adjuvant RT following lymphadenectomy in node-positive melanoma patients prevents local and regional recurrence, the role of adjuvant RT in the treatment of melanoma remains controversial and is underused. RT is highly effective in providing symptom palliation for metastatic melanoma. RT combined with new systemic options, such as immunotherapy, holds promise and is being actively evaluated.
authors.affiliation: Department of Radiation Oncology, Thomas Jefferson University, 111 South 11th Street, Suite G301, Philadelphia, PA 19107, USA. Electronic address: Wenyin.shi@jefferson.edu.
authors.forename: Wenyin
authors.initials: W
authors.lastname: Shi
mesh_terms: D006801:Humans; D007167:Immunotherapy; D008197:Lymph Node Excision; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary; D010166:Palliative Care; D016634:Radiosurgery; D011878:Radiotherapy / Q000379:methods; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary
keywords: Melanoma; Radiation treatment; Stereotactic body radiation treatment (SBRT); Stereotactic radiosurgery (SRS)