title: Medical, legal, and ethical challenges associated with pregnancy and catastrophic brain injury.
abstract: In late 2013, two women from North America gained attention after sustaining catastrophic brain injuries while pregnant. After Marlise Muñoz--who was at 14 weeks of pregnancy when she developed a pulmonary embolism--was pronounced brain dead, hospital officials initially refused to withdraw support, citing a Texas state law requiring them to maintain life-sustaining treatment for a pregnant patient to help to save the fetus. By contrast, when Robyn Benson was pronounced brain dead after a brain hemorrhage at 22 weeks of pregnancy, both her husband and the physicians agreed to continue support until a viable child could be delivered. The Muñoz and Benson cases offer an opportunity to explore the medical, legal, and ethical issues surrounding catastrophic brain injury in pregnant women. It is hoped that the present article will enable clinicians to better appreciate the history and present state of issues involving advance directives for pregnant women, maternal versus fetal interests, and the impact of fetal viability on medical decision making, as well as offer a practical assessment of the various US state laws concerning the rare, yet catastrophic event of brain injury in a pregnant woman.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. Electronic address: burkle.christopher@mayo.edu.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Burkle
authors.affiliation: Department of Obstetrics/Gynecology, North Memorial Medical Center, Robbinsdale, MN, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Tessmer-Tuck
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Eelco F
authors.initials: EF
authors.lastname: Wijdicks
mesh_terms: D000328:Adult; D016223:Advance Directives / Q000941:ethics / Q000331:legislation & jurisprudence; D001926:Brain Death; D001930:Brain Injuries / Q000209:etiology; D005260:Female; D005328:Fetal Viability; D005865:Gestational Age; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications; D008020:Life Support Care / Q000941:ethics / Q000331:legislation & jurisprudence*; D033261:Maternal-Fetal Relations; D026684:Personal Autonomy; D028723:Personhood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011655:Pulmonary Embolism / Q000150:complications; D028761:Withholding Treatment / Q000941:ethics / Q000331:legislation & jurisprudence*
keywords: Brain death; Brain injury; Ethics; Legal issues; Patient autonomy