title: Risperidone long-acting injection and 1-year rehospitalization rate of schizophrenia patients: A retrospective cohort study.
abstract: OBJECTIVE
  We wanted to present a picture of patients with schizophrenia receiving risperidone long-acting injection (RLAI) treatment in a real-world setting.
  
  
  METHODS
  This was a retrospective cohort study; 379 patients with schizophrenia were enrolled and treated with different kinds of antipsychotic agents at E-Da Hospital, and received a 12-month follow up. The patients were distributed into three groups: the all-oral antipsychotic, oral risperidone and RLAI groups. The antipsychotic agents and dosages they used were recorded. The rate of rehospitalization, length of hospital stay, emergency room visits and medical expenditures were assessed.
  
  
  RESULTS
  The RLAI group had a significantly higher rate of hospitalization before enrolment (the all-oral antipsychotic group was 32.1%, the oral risperidone group, 35.9%, and the RLAI group, 88.4%, P < 0.0001). After a 1-year follow up, all three groups were similar in rehospitalization rates (the all-oral antipsychotic group was 28.9%, the oral risperidone group, 30.1%, and the RLAI group, 30.2%, P > 0.999), length of hospital stay and number of emergency room visits during follow up. The most commonly used oral antipsychotics were risperidone (0.5-7 mg/day), quetiapine (65-1200 mg/day), and olanzapine (2-25 mg/day).
  
  
  CONCLUSIONS
  Using RLAI reduces the severity of disease in more difficult patients.
authors.affiliation: Department of Psychiatry, E-Da Hospital, Kaohsiung, Taiwan.|Graduate Institute of Health Care Administration, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Hsue-Wei
authors.initials: HW
authors.lastname: Chan
authors.affiliation: Department of Psychiatry, E-Da Hospital, Kaohsiung, Taiwan.
authors.forename: Chin-Yu
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Department of Quality and Safety, E-Da Hospital, Kaohsiung, Taiwan.|Department of Business Administration, National Sun Yat-Sen University, Kaohsiung, Taiwan.
authors.forename: Wen-Jui
authors.initials: WJ
authors.lastname: Feng
authors.affiliation: Department of Psychiatry, E-Da Hospital, Kaohsiung, Taiwan.|School of Medicine, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Yung-Chieh
authors.initials: YC
authors.lastname: Yen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D010359:Patient Readmission / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D018967:Risperidone / Q000008:administration & dosage / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D013624:Taiwan; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D018967:Risperidone
keywords: antipsychotic agents; hospital emergency service; patient readmission; risperidone; schizophrenia