title: Characterization of metastatic angiomatoid fibrous histiocytoma.
abstract: Angiomatoid fibrous histiocytoma (AFH) is a soft-tissue tumor of low-grade malignancy and uncommon metastatic behavior. In this study, we describe the clinical findings of a metastatic case of AFH in the pelvis. In addition, we characterize 16 patients in the literature with AFH who metastasized over the last 4 decades. The time of appearance of metastases varied substantially and was reported 5 months to 16 years after primary tumor resection. Nine patients metastasized to lymph nodes. Excision of metastatic lymph nodes was usually curative. Pulmonary metastases were associated with fatal outcome. Long-term monitoring should be considered in patients with AFH.
authors.affiliation: Departments of *Pediatrics ‡Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX †Department of Pediatrics, National Cancer Institute, Cairo University, Cairo, Egypt.
authors.forename: Ossama M
authors.initials: OM
authors.lastname: Maher
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.forename: John
authors.initials: J
authors.lastname: Stewart
authors.forename: Cynthia E
authors.initials: CE
authors.lastname: Herzog
mesh_terms: D002648:Child; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology*; D006801:Humans; D009362:Neoplasm Metastasis