title: Effect of alendronate sodium on tooth movement in ovariectomized rats.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the effect of two different dosages of alendronate on induced orthodontic movement in an experimental model involving rats with osteoporosis following ovariectomy.
  
  
  METHODS
  Female Wistar rats (Rattus norvegicus) eight weeks of age were divided into four groups (n=12/group): ovariectomized (OVX group); ovariectomized and treated with alendronate sodium at 1mg/kg (Group OVX+ALN1); ovariectomized and treated with alendronate sodium at 2mg/kg (Group OVX+ALN2); and sham operated (control). Three months after ovariectomy, the maxillary right first molar was submitted to movement for five and seven days. After the death of the animals, the maxilla were removed and processed for microscopic evaluation. The maxillary left first molar (without movement) was used for comparison purposes in all groups. The samples were processed for the quantification of alveolar bone and tooth movement.
  
  
  RESULTS
  Intragroup comparisons showed significant movement after five and seven days (p<0.05) for all groups. Comparison among groups revealed greater tooth movement in the OVX group (p<0.05), on day 7.
  
  
  CONCLUSIONS
  Both alendronate sodium doses similarly decreased tooth movement in ovariectomized rats (p>0.05). Movement in ovariectomized+alendronate groups were also smaller than non-ovariectomized rats, however without statistical difference.
authors.affiliation: Department of Odontology, Universidade Federal de Sergipe, Aracaju, Sergipe, Brazil. Electronic address: marciosalazar@hotmail.com.
authors.forename: Marcio
authors.initials: M
authors.lastname: Salazar
authors.affiliation: Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Luzmarina
authors.initials: L
authors.lastname: Hernandes
authors.affiliation: Department of Dentistry - Orthodontics, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
authors.forename: Adilson Luiz
authors.initials: AL
authors.lastname: Ramos
authors.affiliation: Department of Odontology, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Brunamélia de Oliveira
authors.initials: Bde O
authors.lastname: Salazar
authors.affiliation: Department of Odontology, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Kelly Regina
authors.initials: KR
authors.lastname: Micheletti
authors.affiliation: Department of Odontology, Universidade Federal de Sergipe, Lagarto, Sergipe, Brazil.
authors.forename: Luiz Renato
authors.initials: LR
authors.lastname: Paranhos
authors.affiliation: Department of Orthodontics, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Marcos Rogério
authors.initials: MR
authors.lastname: de Mendonça
authors.affiliation: Department of Orthodontics, Universidade Estadual Paulista, Araçatuba, São Paulo, Brazil.
authors.forename: Osmar Aparecido
authors.initials: OA
authors.lastname: Cuoghi
mesh_terms: D019386:Alendronate / Q000494:pharmacology*; D016301:Alveolar Bone Loss; D000818:Animals; D005260:Female; D010010:Osteoclasts / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D014087:Tooth Movement Techniques
chemical_list: D019386:Alendronate
keywords: Alendronate sodium; Osteoporosis; Ovariectomy; Tooth movement