title: Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
abstract: Autosomal-dominant polycystic kidney disease (ADPKD) affects up to 12 million individuals and is the fourth most common cause for renal replacement therapy worldwide. There have been many recent advances in the understanding of its molecular genetics and biology, and in the diagnosis and management of its manifestations. Yet, diagnosis, evaluation, prevention, and treatment vary widely and there are no broadly accepted practice guidelines. Barriers to translation of basic science breakthroughs to clinical care exist, with considerable heterogeneity across countries. The Kidney Disease: Improving Global Outcomes Controversies Conference on ADPKD brought together a panel of multidisciplinary clinical expertise and engaged patients to identify areas of consensus, gaps in knowledge, and research and health-care priorities related to diagnosis; monitoring of kidney disease progression; management of hypertension, renal function decline and complications; end-stage renal disease; extrarenal complications; and practical integrated patient support. These are summarized in this review.
authors.affiliation: Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Arlene B
authors.initials: AB
authors.lastname: Chapman
authors.affiliation: Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Devuyst
authors.affiliation: University of Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Kai-Uwe
authors.initials: KU
authors.lastname: Eckardt
authors.affiliation: University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Ron T
authors.initials: RT
authors.lastname: Gansevoort
authors.affiliation: PKD International, Geneva, Switzerland.
authors.forename: Tess
authors.initials: T
authors.lastname: Harris
authors.affiliation: Juntendo University Graduate School of Medicine, Bunkyou, Tokyo, Japan.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horie
authors.affiliation: Hennepin County Medical Center, Minneapolis, Minnesota, USA.
authors.forename: Bertram L
authors.initials: BL
authors.lastname: Kasiske
authors.affiliation: PKD Foundation, Kansas City, Missouri, USA.
authors.forename: Dwight
authors.initials: D
authors.lastname: Odland
authors.affiliation: University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: York
authors.initials: Y
authors.lastname: Pei
authors.affiliation: Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA.
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Perrone
authors.affiliation: Université Catholique de Louvain, Brussels, Belgium.
authors.forename: Yves
authors.initials: Y
authors.lastname: Pirson
authors.affiliation: University of Colorado, Denver, Colorado, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Schrier
authors.affiliation: Fundació Puigvert, REDinREN, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: Torra
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Vicente E
authors.initials: VE
authors.lastname: Torres
authors.affiliation: University of Maryland School of Medicine, Baltimore, Maryland, USA.
authors.forename: Terry
authors.initials: T
authors.lastname: Watnick
authors.affiliation: University College London, London, UK.
authors.forename: David C
authors.initials: DC
authors.lastname: Wheeler
mesh_terms: D032921:Consensus; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*