title: MicroRNA Regulating Glutathione S-Transferase P1 in Prostate Cancer.
abstract: Glutathione S-transferase P1 (GSTP1), an enzyme involved in detoxification process, is frequently inactivated in prostate cancer due to epigenetic modifications. Throughin silicoanalysis we identified a subset of miRNAs that are putative targets in regulating GSTP1. miRNAs are small endogenous non-coding RNA that are critical regulators of various physiologic and pathologic processes and their level of expression may play a precise role in early diagnosis and prognosis of cancer. These small molecules have been detected in a wide variety of human biological specimens including blood, serum, urine, ejaculate and tissues, which could be utilized as clinically useful biomarker in early detection and prognosis of prostate cancer. The chapter summarizes the current knowledge about miRNA involved in GSTP1 regulation in prostate cancer and their potential as useful biomarkers of disease for early detection and prognosis, along with challenges and limitations in this development.
authors.affiliation: Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, Ohio, USA ; Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
authors.forename: Savita
authors.initials: S
authors.lastname: Singh
authors.affiliation: Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, Ohio, USA ; Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA.
authors.forename: Girish C
authors.initials: GC
authors.lastname: Shukla
authors.affiliation: Department of Urology, Case Western Reserve University & University Hospitals Case Medical Center, Cleveland, Ohio, USA ; Division of General Medical Sciences, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gupta
keywords: GSTP1; epigenetics; miRNA; oxidative DNA damage; prostate cancer