title: Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil.
abstract: Particle rearrangements, compaction under pressure and in vitro dissolution have been evaluated after melt dispersion of ibuprofen, Avicel and Aerosil. The Cooper-Eaton and Kuno equations were utilized for the determination of particle rearrangement and compression behavior from tap density and compact data. Particle rearrangement could be divided into two stages as primary and secondary rearrangement. Transitional tapping between the stages was found to be 20-25 taps in ibuprofen crystalline powder, which was increased up to 45 taps with all formulated powders. Compaction in the rearrangement stages was increased in all the formulations with respect to pure ibuprofen. Significantly increased compaction of ibuprofen under pressure can be achieved using Avicel by melt dispersion technique, which could be beneficial in ibuprofen tablet manufacturing by direct compression. SEM, FTIR and DSC have been utilized for physicochemical characterization of the melt dispersion powder materials. Dissolution of ibuprofen from compacted tablet of physical mixture and melt dispersion particles has also been improved greatly in the following order: Ibc<Ibsmd1<Ibsmd2<Ibsmp10<Ibsmd5<Ibsmd10.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
authors.forename: Subrata
authors.initials: S
authors.lastname: Mallick
authors.affiliation: Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur, Mohuda, Orissa, India.
authors.forename: Saroj
authors.initials: S
authors.lastname: Kumar Pradhan
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
authors.forename: Muronia
authors.initials: M
authors.lastname: Chandran
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
authors.forename: Manoj
authors.initials: M
authors.lastname: Acharya
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
authors.forename: Tanmayee
authors.initials: T
authors.lastname: Digdarsini
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Kalinganagar, Bhubaneswar 751003, Orissa, India.
authors.forename: Rajaram
authors.initials: R
authors.lastname: Mohapatra
keywords: Aerosil lubricated mcc; Compression behavior; Ibuprofen; In vitro dissolution; Melt dispersion; Particle rearrangement