title: Clinical and in vitro evidence for the antimicrobial therapy in Burkholderia cepacia complex infections.
abstract: Treatment of infections caused by Burkholderia cepacia complex (Bcc) in cystic fibrosis (CF) patients poses a complex problem. Bcc is multidrug-resistant due to innate and acquired mechanisms of resistance. As CF patients receive multiple courses of antibiotics, susceptibility patterns of strains from CF patients may differ from those noted in strains from non-CF patients. Thus, there was a need for assessing in vitro and clinical data to guide antimicrobial therapy in these patients. A systematic search of literature, followed by extraction and analysis of available information from human and in vitro studies was done. The results of the analysis are used to address various aspects like use of antimicrobials for pulmonary and non-pulmonary infections, use of combination versus monotherapy, early eradication, duration of therapy, route of administration, management of biofilms, development of resistance during therapy, pharmacokinetics-pharmacodynamics correlations, therapy in post-transplant patients and newer drugs in Bcc-infected CF patients.
authors.affiliation: Deparatment of Medical Microbiology, PGIMER, Chandigarh 160022, India.
authors.forename: Vikas
authors.initials: V
authors.lastname: Gautam
authors.forename: Nusrat
authors.initials: N
authors.lastname: Shafiq
authors.forename: Meenu
authors.initials: M
authors.lastname: Singh
authors.forename: Pallab
authors.initials: P
authors.lastname: Ray
authors.forename: Lipika
authors.initials: L
authors.lastname: Singhal
authors.forename: Nishant P
authors.initials: NP
authors.lastname: Jaiswal
authors.forename: Amber
authors.initials: A
authors.lastname: Prasad
authors.forename: Shaunik
authors.initials: S
authors.lastname: Singh
authors.forename: Amit
authors.initials: A
authors.lastname: Agarwal
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use*; D019121:Burkholderia Infections / Q000188:drug therapy*; D042602:Burkholderia cepacia complex / Q000472:pathogenicity*; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans
chemical_list: D000890:Anti-Infective Agents
keywords: Burkholderia cepacia; cystic fibrosis; eradication; review; therapy