title: Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease.
abstract: BACKGROUND
  Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.
  
  
  METHODS
  Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population-based case-control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.
  
  
  RESULTS
  In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.
  
  
  CONCLUSIONS
  Electron transport chain (ETC) activity is not altered in PD in this well-characterized cohort when compared with community-matched controls but appears to be affected by environmental toxins, such as mitochondria-inhibiting pesticides.
authors.affiliation: Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.|Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.
authors.forename: Jeff M
authors.initials: JM
authors.lastname: Bronstein
authors.affiliation: Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Paul
authors.affiliation: Department of Neurology, David Geffen School of Medicine, Los Angeles, California, USA.|Greater Los Angeles Veterans Administration Medical Center, Los Angeles, California, USA.
authors.forename: Laurice
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
authors.forename: Richard H
authors.initials: RH
authors.lastname: Haas
authors.affiliation: Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Shults
authors.affiliation: Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
authors.forename: Thuy
authors.initials: T
authors.lastname: Le
authors.affiliation: Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
authors.forename: Beate
authors.initials: B
authors.lastname: Ritz
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D016022:Case-Control Studies; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism*; D042967:Electron Transport Complex I / Q000378:metabolism; D014450:Electron Transport Complex III / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D040362:Geographic Information Systems / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism*; D010575:Pesticides / Q000633:toxicity*; D012307:Risk Factors
chemical_list: D045222:Electron Transport Chain Complex Proteins; D010575:Pesticides; D009251:NADPH-Ferrihemoprotein Reductase; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III
keywords: complex I; electron transport chain