title: A comparison study of immune-inflammatory response in electroacupuncture and transcutaneous electrical nerve stimulation for patients undergoing supratentorial craniotomy.
abstract: OBJECTIVE
  The effect of transcutaneous electrical nerve stimulation (TENS) on immuno-inflammatory response was tested and the differences between electroacupuncture (EA) and TENS in immuno-inflammatory response in patients undergoing supratentorial craniotomy were explored.
  
  
  METHODS
  51 patients received craniotomy were randomly divided into 3 groups: control (group C, n=18), EA (group A, n=19) and TENS (group T, n=14) groups. Blood samples were collected before anesthesia (T0) and 30 min (T1), 2 h (T2) and 4 h (T3) after induction of anesthesia to measure the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-8, IL-10, IgM, IgA and IgG.
  
  
  RESULTS
  No significant difference existed between group A and group T during craniotomy. IgM and IgA decreased significantly in group C compared with groups A and T at T2 and T3 time points. Compared with group C, there were significant differences in TNF-α, IgM and IgA levels at T0 in groups A and T; no significant difference was found in the levels of IgG, IL-10 and IL-8.
  
  
  CONCLUSIONS
  EA and TENS could reduce immunosuppression in patients undergoing supratentorial craniotomy and it has significance in choice of treatment in immunosuppressive therapy.
authors.affiliation: Department of Anesthesiology, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
authors.forename: Guoyan
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Beijing Tiantan Hospital Beijing, China.
authors.forename: Shuqin
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of General Surgery, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
authors.forename: Fangcai
authors.initials: F
authors.lastname: Lin
authors.affiliation: Department of Anesthesiology and Pain Management, Beijing Sanbo Brain Hospital Beijing, China.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Wang
keywords: Transcutaneous electrical nerve stimulation (TENS); electroacupuncture (EA); immuno-inflammatory; supratentorial craniotomy