title: [Is paraoxonase 1 a marker of cardiovascular risk in youth with type 1 diabetes? (Study about 109 cases)].
abstract: OBJECTIVE
  We purpose to verify if paraoxonase 1 (PON1) activity may be a marker of cardiovascular risk in a young Tunisian population with type 1 diabetes (T1D).
  
  
  METHODS
  PON1 activity was measured by a kinetic method using paraoxon as substrate. The other parameters were determined by automated methods.
  
  
  RESULTS
  One hundred and nine children and adolescents with T1D and 97 healthy subjects were involved in this study. PON1 activity and PON1/HDL-cholesterol ratio were significantly decreased in diabetics (303 ± 174 vs. 372 ± 180 U/L and 221 ± 139 vs. 298 ± 20 1U/mmol, P=0.006, P=0.002, respectively) compared to controls. A significant increase in total cholesterol, LDL-c and microalbuminuria was observed in diabetics compared to controls. PON1 activity was decreased by 9.5% in patients with diabetes duration ≥ 6 years, by 28.4% for those with fasting glycemia ≥ 7 mmol/L (P<0.001), by 14% in those with HbA1c ≥ 8% and by 12.3% for diabetics with dyslipidemia. PON1 activity is reduced when the number of cardiovascular risk factors increases (P<0.001).
  
  
  CONCLUSIONS
  PON1 seems to be associated to cardiovascular risk markers in T1D. This result remains to be seen. Nevertheless, improving PON1 activity could be a significant target for reducing cardiovascular risk.
authors.affiliation: Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie; Hôpital Universitaire Fattouma Bourguiba, laboratoire de recherche « biologie moléculaire appliquée aux maladies cardiovasculaires, aux néphropathies et à la pharmacogénomique » LR12SP11, 5000 Monastir, Tunisie. Electronic address: onsfekihsallem@gmail.com.
authors.forename: Ons
authors.initials: O
authors.lastname: Fekih
authors.affiliation: Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie; Hôpital Universitaire Fattouma Bourguiba, laboratoire de recherche « biologie moléculaire appliquée aux maladies cardiovasculaires, aux néphropathies et à la pharmacogénomique » LR12SP11, 5000 Monastir, Tunisie.
authors.forename: Sonia
authors.initials: S
authors.lastname: Triki
authors.affiliation: Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie.
authors.forename: Ilhem
authors.initials: I
authors.lastname: Hellara
authors.affiliation: Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie; Hôpital Universitaire Fattouma Bourguiba, laboratoire de recherche « biologie moléculaire appliquée aux maladies cardiovasculaires, aux néphropathies et à la pharmacogénomique » LR12SP11, 5000 Monastir, Tunisie.
authors.forename: Fadoua
authors.initials: F
authors.lastname: Neffati
authors.affiliation: Hôpital universitaire Fattouma Bourguiba, département de pédiatrie, 5000 Monastir, Tunisie.
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Chouchane
authors.affiliation: Hôpital universitaire Fattouma Bourguiba, département de pédiatrie, 5000 Monastir, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Neji Gueddiche
authors.affiliation: Hôpital Universitaire Fattouma Bourguiba, laboratoire de biochimie-toxicologie, 5000 Monastir, Tunisie.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Fadhel Najjar
mesh_terms: D000293:Adolescent; D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D043303:Aryldialkylphosphatase; D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human; C468406:PON1 protein, human