title: Antifouling coatings for dental implants: Polyethylene glycol-like coatings on titanium by plasma polymerization.
abstract: Titanium dental implants are commonly used for the replacement of lost teeth, but they present a considerable number of failures due to the infection on surrounding tissues. The aim of this paper is the development of a polyethylene glycol-like (PEG-like) coating on the titanium surface by plasma polymerization to obtain a novel improved surface with suitable low bacterial adhesion and adequate cell response. Surface analysis data of these coatings are presented, in particular, water contact angle, surface roughness, and film chemistry, demonstrating the presence of a PEG-like coating. Streptococcus sanguinis and Lactobacillus salivarius bacterial adhesion assays showed a decreased adhesion on the plasma polymerized samples, while cell adhesion of fibroblasts and osteoblasts on the treated surfaces was similar to control surfaces. Thus, the PEG-like antifouling coating obtained by plasma polymerization on Ti confers this biomaterial's highly suitable properties for dental applications, as they reduce the possibility of infection while allowing the tissue integration around the implant.
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, E. U. d'Enginyeria Tècnica Industrial de Barcelona, Technical University of Catalonia (UPC), C/ Comte d'Urgell 187, 08036 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Maria de Luna 11, Ed. CEEI, 50118 Zaragoza, Spain; and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Judit
authors.initials: J
authors.lastname: Buxadera-Palomero
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, E. T. S. d'Enginyeria Industrial de Barcelona, Technical University of Catalonia (UPC), Av. Diagonal 647, 08028 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Maria de Luna 11, Ed. CEEI, 50118 Zaragoza, Spain; and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Canal
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, E. T. S. d'Enginyeria Industrial de Barcelona, Technical University of Catalonia (UPC), Av. Diagonal 647, 08028 Barcelona, Spain and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Sergi
authors.initials: S
authors.lastname: Torrent-Camarero
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, E. T. S. d'Enginyeria Industrial de Barcelona, Technical University of Catalonia (UPC), Av. Diagonal 647, 08028 Barcelona, Spain and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Garrido
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, E. T. S. d'Enginyeria Industrial de Barcelona, Technical University of Catalonia (UPC), Av. Diagonal 647, 08028 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Maria de Luna 11, Ed. CEEI, 50118 Zaragoza, Spain; and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Javier Gil
authors.affiliation: Biomaterials, Biomechanics and Tissue Engineering Group, E. U. d'Enginyeria Tècnica Industrial de Barcelona, Technical University of Catalonia (UPC), C/ Comte d'Urgell 187, 08036 Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Maria de Luna 11, Ed. CEEI, 50118 Zaragoza, Spain; and Centre for Research in NanoEngineering (CRNE)-UPC, C/Pascual i Vila 15, 08028 Barcelona, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rodríguez
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D015921:Dental Implants / Q000382:microbiology*; D007778:Lactobacillus / Q000187:drug effects / Q000502:physiology; D058626:Plasma Gases; D011092:Polyethylene Glycols / Q000494:pharmacology*; D058105:Polymerization; D013291:Streptococcus / Q000187:drug effects / Q000502:physiology; D014025:Titanium
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D058626:Plasma Gases; D011092:Polyethylene Glycols; D014025:Titanium