title: The RNA polymerase II preinitiation complex. Through what pathway is the complex assembled?
abstract: The general transcription factors required for the assembly of the RNA polymerase II preinitiation complex at TATA-dependent promoters are well known. However, recent studies point to two quite distinct pathways for assembly of these components into functional transcription complexes. In this review, the two pathways are compared and potential implications for gene regulatory mechanisms are discussed.
authors.affiliation: a Department of Molecular Genetics; Lerner Research Institute; Cleveland Clinic; Cleveland, OH USA.
authors.forename: Donal S
authors.initials: DS
authors.lastname: Luse
mesh_terms: D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic / Q000502:physiology; D012319:RNA Polymerase II / Q000737:chemistry / Q000502:physiology*; D016385:TATA Box; D035165:Transcription Factors, General / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D061785:Transcription Initiation, Genetic; D015003:Yeasts / Q000235:genetics
chemical_list: D035165:Transcription Factors, General; D012319:RNA Polymerase II
keywords: RNA polymerase II; TBP; TFIIB; TFIIE; TFIIF; TFIIH; general transcription factors; preinitiation complex