title: Quantum dot display enhances activity of a phosphotriesterase trimer.
abstract: Phosphotriesterase was engineered into a spontaneously forming trimer by appending it to a synthetic collagen-like triple-helix motif. Enzymatic hydrolysis of the insecticide and organophosphate nerve agent simulant paraoxon was then examined. Assembling the phosphotriesterase trimer onto semiconductor quantum dots increased the enzyme's catalytic rate and efficiency.
authors.affiliation: Center for Bio/Molecular Science and Engineering, Code 6900, U. S. Naval Research Laboratory, Washington, DC 20375, USA. igor.medintz@nrl.navy.mil.
authors.forename: Joyce C
authors.initials: JC
authors.lastname: Breger
authors.forename: Scott A
authors.initials: SA
authors.lastname: Walper
authors.forename: Eunkeu
authors.initials: E
authors.lastname: Oh
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Susumu
authors.forename: Michael H
authors.initials: MH
authors.lastname: Stewart
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Deschamps
authors.forename: Igor L
authors.initials: IL
authors.lastname: Medintz
mesh_terms: D055162:Biocatalysis; D042063:Caulobacteraceae / Q000201:enzymology; D006868:Hydrolysis; D007700:Kinetics; D008958:Models, Molecular; D044345:Phosphoric Triester Hydrolases / Q000737:chemistry* / Q000378:metabolism*; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D044345:Phosphoric Triester Hydrolases