title: [Benign course of diffuse cutaneous mastocytosis with massive blisters].
abstract: BACKGROUND
  Diffuse cutaneous mastocytosis is a rare disease with increased numbers of mast cells and development of blisters, which can be easily overlooked.
  
  
  METHODS
  A 6-month-old girl was presented by her parents with acute onset of numerous, disseminated bullae on her body. Histology revealed numerous mast cells in a skin sample and highly elevated serum tryptase levels were detected. The diagnosis of diffuse cutaneous mastocytosis was made. The patient was medically treated with glucocorticoids and antibiotics. Within a few years of time a complete remission of developing bullae, a major clinical improvement as well as a continuous decrease of basal tryptase was seen. Today, the girl is 14 years old and without any apparent limitation due to the disease and in fact she is very successful in competitive sports.
  
  
  CONCLUSIONS
  Despite often severe symptoms at first manifestation, this clinical development showing a benign course is typical in children.
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Zink
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Grosber
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Schuch
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Biedermann
authors.affiliation: Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Klinikum rechts der Isar, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland. knut.brockow@lrz.tu-muenchen.de.
authors.forename: K
authors.initials: K
authors.lastname: Brockow
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001768:Blister / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D034701:Mastocytosis, Cutaneous / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids
keywords: Blister formation; Bullous mastocytosis; Mast cells; Tryptase; Urticaria pigmentosa