title: Expanding the scope of strained-alkyne chemistry: a protection-deprotection strategy via the formation of a dicobalt-hexacarbonyl complex.
abstract: A protection-deprotection strategy for strained alkynes used for bioorthogonal chemistry is reported. A strained alkyne can be protected with dicobalt-octacarbonyl and we demonstrate for the first time that a strained alkyne can be re-formed and isolated under mild reaction conditions for further bioorthogonal reactivity. The protection-deprotection strategy herein reported will expand the versatility of strained alkynes for the preparation of substrates in chemical biology and materials applications.
authors.affiliation: Department of Chemistry and the Centre for Materials and Biomaterials Research (CAMBR), The University of Western Ontario, 1151 Richmond St., London, Ontario N6A 5B7, Canada. mworkent@uwo.ca joe.gilroy@uwo.ca.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Gobbo
authors.forename: Tommaso
authors.initials: T
authors.lastname: Romagnoli
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Barbon
authors.forename: Jacquelyn T
authors.initials: JT
authors.lastname: Price
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keir
authors.forename: Joe B
authors.initials: JB
authors.lastname: Gilroy
authors.forename: Mark S
authors.initials: MS
authors.lastname: Workentin