title: Cyclic comonomers for the synthesis of carboxylic acid and amine functionalized poly(L-lactic acid).
abstract: Degradable aliphatic polyesters such as poly(lactic acid) are widely used in biomedical applications, however, they lack functional moieties along the polymer backbone that are amenable for functionalization reactions or could be the basis for interactions with biological systems. Here we present a straightforward route for the synthesis of functional α-ω epoxyesters as comonomers for lactide polymerization. Salient features of these highly functionalized epoxides are versatility in functionality and a short synthetic route of less than four steps. The α-ω epoxyesters presented serve as a means to introduce carboxylic acid and amine functional groups into poly(lactic acid) polymers via ring-opening copolymerization.
authors.affiliation: Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier Str. 31, Freiburg 79104, Germany. markus.heiny@makro.uni-freiburg.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Heiny
authors.affiliation: Institute for Macromolecular Chemistry, University of Freiburg, Stefan-Meier Str. 31, Freiburg 79104, Germany. prasad.shastri@gmail.com.|BIOSS Centre for Biological Signalling Studies, University of Freiburg, Schänzlestr. 18, Freiburg 79104, Germany. prasad.shastri@gmail.com.
authors.forename: V Prasad
authors.initials: VP
authors.lastname: Shastri
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D001672:Biocompatible Materials / Q000737:chemistry; D001673:Biodegradation, Environmental; D002264:Carboxylic Acids / Q000138:chemical synthesis*; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D019344:Lactic Acid / Q000737:chemistry*; D015394:Molecular Structure; D011091:Polyesters; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*
chemical_list: D000588:Amines; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D004852:Epoxy Compounds; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)