title: Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients.
abstract: We investigated kidney function outcome in 24 chronic hepatitis C genotype 1 patients coinfected with HIV receiving telaprevir in a single tertiary care hospital in Spain. A statistically significant median (interquartile range) decrease in estimated glomerular filtration rate (eGFR, ml/min/1.73 m) relative to baseline [93.6 (73.0-109.0)] was seen at weeks 4 [86.5 (34.0-112.0), P = 0.014], 8 [90.0 (49.0-111.0), P = 0.026] and 12 [89.5 (54.0-113.0), P = 0.017]. These changes reversed after telaprevir discontinuation. Patients presenting an eGFR decrease had a higher risk of haematological toxicity.
authors.affiliation: HIV Unit, Infectious Diseases Service, Hospital Universitari de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Van den Eynde
authors.forename: Jordi
authors.initials: J
authors.lastname: Curto
authors.forename: Elena
authors.initials: E
authors.lastname: Ferrer
authors.forename: Arkaitz
authors.initials: A
authors.lastname: Imaz
authors.forename: Maria
authors.initials: M
authors.lastname: Saumoy
authors.forename: Silvana
authors.initials: S
authors.lastname: Di Yacovo
authors.forename: Antonia
authors.initials: A
authors.lastname: Vila
authors.forename: Daniel
authors.initials: D
authors.lastname: Podzamczer
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D060085:Coinfection / Q000188:drug therapy*; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy*; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000009:adverse effects* / Q000627:therapeutic use*; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use; D013030:Spain; D062606:Tertiary Care Centers
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D009842:Oligopeptides; D012254:Ribavirin; C486464:telaprevir; D003404:Creatinine