title: Unusual soft tissue infiltrates with 18F-FDG uptake in a patient with hairy cell leukemia.
abstract: Hairy cell leukemia (HCL) is an uncommon B-cell lymphoproliferative disorder, representing approximately 2% of leukemias. Diagnostic features include pancytopenia, splenomegaly, bone marrow reticulin fibrosis, and circulating hairy cells. Less commonly, there may be involvement of the liver and lymph nodes. We present a case of a 53-year-old man with HCL who was found to have soft tissue masses within the mediastinum and neck during pretreatment workup. An F-FDG PET/CT scan was requested to assess these lesions before treatment. These extensive infiltrates were FDG avid, and core biopsy of the mediastinal tissue was undertaken. Results were consistent with HCL.
authors.affiliation: From the *Specialised PET Services Queensland, Royal Brisbane and Women's Hospital, Brisbane; †Pathology Queensland, Sunshine Coast; ‡Department of Nuclear Medicine, Royal Brisbane and Women's Hospital; and §Faculty of Medicine and Biomedical Science, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Glenna
authors.initials: G
authors.lastname: Gibson
authors.forename: Jerome
authors.initials: J
authors.lastname: Lai
authors.forename: Paul
authors.initials: P
authors.lastname: Thomas
mesh_terms: D019788:Fluorodeoxyglucose F18; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D017254:Leukemic Infiltration; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18