title: Electroacupuncture effects on cortical neurons, as well as Janus kinase 2-signal transducer and activator of transcription 3 signal transduction pathway, in a rat model of cerebral ischemia.
abstract: The present study established a model of focal cerebral ischemia through heat-coagulation induced occlusion of the middle cerebral artery. Following electroacupuncture at Baihui (GV20) and Dazhui (GV14), or intracerebroventricular infusion of AG490, a Janus kinase 2 phosphorylation inhibitor, the amount of necrotic or degenerated neurons in the ischemic cerebral cortex decreased, neuronal swelling was ameliorated, and expression of phosphorylated Janus kinase 2 and signal transducer and activator of transcription 3 decreased. Results confirmed that electroacupuncture promoted neuronal repair in the cerebral cortex by reducing expression of phosphorylated Janus kinase 2 and signal transducer and activator of transcription 3, as well as weakening the phosphorylated activation, thereby blocking abnormal activation of the Janus kinase 2- signal transducer and activator of transcription 3 signal transduction pathway.
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Nenggui
authors.initials: N
authors.lastname: Xu
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yi
authors.affiliation: Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China.
authors.forename: Kangbai
authors.initials: K
authors.lastname: Huang
keywords: AG490; JAK2-STAT3; cerebral ischemia; electroacupuncture; neurons