title: Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway.
abstract: Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood. We investigated the prevalence, phenotype and trafficking property of Th17 cells in patients with cervical cancer. Our results showed that Th17 cells highly aggregated within tumor tissues in an activated phenotype with markedly increased expression of CCR6. Correspondingly, level of CCL20 in the tumor tissues was significantly higher than that in non-tumor and normal control tissues, and strongly positively associated with Th17 cells. Further, in vitro migration assay showed CCL20 had effective chemotaxis to circulating Th17 cells. In conclusion, Th17 cells are recruited into tumor tissues preferentially through CCR6-CCL20 pathway, which can serve as a novel therapeutic target for cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Hangzhou Obstetrics and Gynecology Hospital, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yu
authors.affiliation: Department of Obstetrics and Gynecology, Hangzhou Obstetrics and Gynecology Hospital, Hangzhou First People's Hospital, Hangzhou, China.
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Lou
authors.affiliation: Department of Pathology, Yiwu Maternity and Child Care Hospital, Yiwu, Zhejiang Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
mesh_terms: D054418:Chemokine CCL20 / Q000378:metabolism*; D002633:Chemotaxis; D005260:Female; D006801:Humans; D010641:Phenotype; D054399:Receptors, CCR6 / Q000378:metabolism*; D058504:Th17 Cells / Q000166:cytology* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000378:metabolism*
chemical_list: C108355:CCL20 protein, human; D054418:Chemokine CCL20; D054399:Receptors, CCR6