title: Comparison of renal function following donor nephrectomy versus radical nephrectomy for renal tumor.
abstract: In this study, we compared renal function in patients after donor nephrectomy (DN) and radical nephrectomy (RN). We retrospectively reviewed 68 patients (mean follow-up 15 months), including 30 patients who had undergone DN and 38 patients who had undergone RN. The study was performed between April 2006 and July 2010 at a single institute. Patients were matched for age and co-morbidities (hypertension and diabetes mellitus). We calculated the estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease study group equation. Parameters studied included GFR (≥60 to <60 mL/min/1.73 m 2 ), serum creatinine (>2.0 mg/dL), metabolic acidosis (serum bicarbonate <22 mmol/L) and proteinuria (>30 mg). There were no significant demographic differences between the two study groups. After a mean follow-up of 15 months, low eGFR (<60 mL/min/1.73 m 2 ) was seen in 28% and 6.7% of patients in the RN and DN groups, respectively (P = 0.03). Similarly, proteinuria was seen in 21% vs 0%, P = 0.007, and de novo elevated creatinine was seen in 13% vs 0%, respectively P = 0.04; thus the changes were greater in the RN group. Our study shows that undergoing RN had a significantly greater risk of developing renal insufficiency and proteinuria compared with age-and co-morbidity-matched patients undergoing DN. We concluded that patients undergoing RN show a significantly greater risk of developing renal insufficiency and proteinuria compared with the patients undergoing DN.
authors.affiliation: Jackson South Hospital, Miami, FL, USA.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Etafy
authors.forename: Fatma
authors.initials: F
authors.lastname: Saleh
authors.forename: M A
authors.initials: MA
authors.lastname: Abdel Aal
authors.forename: Maher
authors.initials: M
authors.lastname: Gawish
authors.forename: Gamal
authors.initials: G
authors.lastname: Morsy
mesh_terms: D000138:Acidosis / Q000209:etiology / Q000503:physiopathology; D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology* / Q000601:surgery*; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects / Q000379:methods*; D011507:Proteinuria / Q000209:etiology / Q000503:physiopathology; D020127:Recovery of Function; D051437:Renal Insufficiency / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003404:Creatinine