title: Clinicopathologic features of renal epithelioid angiomyolipoma: report of one case and review of literatures.
abstract: Epithelioid angiomyolipoma (EAML) is a rare renal mesenchymal tumor with malignant potential and is frequently associated with tuberous sclerosis complex (TSC). As metastasis of the tumor cells occur early, EAML is considered a potentially malignant tumor type and intrigues further research on it. Under the microscope, we could find the tumor was composed of atypical polygonal cells sheet mixed with classic angiomyolipoma (AML) components such as blood vessels with notable thick vascular walls, smooth muscle-like cells and adipocytes. Immunohistochemical studies showed that epithelioid cells were focally positive for vimentin, melanocytic markers (HMB-45), myoid markers (α-smooth muscle actin), CD34 and CD68; negative for cytokeratin, epithelial membrane antigen, CD10, and S-100. And the Ki67 index showed approximately 3%. Here, we report the morphological and immunohistochemical features of clinically or histologically malignant renal EAML and discuss its diagnosis, differential diagnosis and the prognosis.
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Guobin
authors.initials: G
authors.lastname: Tan
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Mingning
authors.initials: M
authors.lastname: Qiu
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Lieqian
authors.initials: L
authors.lastname: Chen
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.affiliation: Laboratory of Urologic Surgery, Affiliated Hospital of Guangdong Medical College Zhanjiang 524001, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Liu
mesh_terms: D018207:Angiomyolipoma / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D015622:Epithelioid Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor
keywords: Epithelioid; angiomyolipoma; diagnosis; immunohistochemistry