title: Prenatal diagnosis of trisomy 6q25.3-qter and monosomy 10q26.12-qter by array CGH in a fetus with an apparently normal karyotype.
abstract: We present the prenatal case of a 12.5-Mb duplication involving 6q25-qter and a 12.2-Mb deletion encompassing 10q26-qter diagnosed by aCGH, while conventional karyotype showed normal results. The genotype-phenotype correlation between individual microarray and clinical findings adds to the emerging atlas of chromosomal abnormalities associated with specific prenatal ultrasound abnormalities.
authors.affiliation: Department of Obstetrics and Gynecology, University of Virginia Health System Charlottesville, Virginia.
authors.forename: Ponnila S
authors.initials: PS
authors.lastname: Marinescu
authors.affiliation: Division of Medical Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of University of Pittsburgh Medical Center Pittsburgh, Pennsylvania.
authors.forename: Devereux N
authors.initials: DN
authors.lastname: Saller
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
authors.forename: W Tony
authors.initials: WT
authors.lastname: Parks
authors.affiliation: Division of Medical Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of University of Pittsburgh Medical Center Pittsburgh, Pennsylvania ; Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Yatsenko
authors.affiliation: Division of Medical Genetics, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Hospital of University of Pittsburgh Medical Center Pittsburgh, Pennsylvania ; Department of Pathology, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania ; Department of Human Genetics, University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Rajkovic
keywords: Array CGH; deletion 10q; duplication 6q; fetal ultrasound; prenatal diagnosis; unbalanced translocation