title: Spectral-domain Optical Coherence Tomography Patterns in Intraocular Lymphoma.
abstract: OBJECTIVE
  To examine spectral-domain optical coherence tomography (SD-OCT) patterns in intraocular lymphoma (IOL).
  
  
  METHODS
  Records of 13 patients (21 eyes) with IOL were retrospectively reviewed. SD-OCT was evaluated at initial visit and during follow-up.
  
  
  RESULTS
  SD-OCT images at initial visit demonstrated disruption of the ellipsoid zone (8 eyes, 38.1%) and hyperreflective nodules at the retinal pigment epithelium (RPE) level (5 eyes, 23.8%). During follow-up, disruption of the ellipsoid zone (10 eyes, 47.6%) and hyperreflective nodules at the RPE level (7 eyes, 33.3%) were noted. In 5 eyes showing hyperreflective nodules at the RPE level, the hyperreflective nodules were reduced after treatment with intravitreal methotrexate.
  
  
  CONCLUSIONS
  Hyperreflective nodules in the outer retina and disruption of the ellipsoid zone were observed in nearly one-half of patients with IOL over time. SD-OCT may allow for early detection of small macular abnormalities and aid in monitoring of treatment efficacy in this disease.
authors.affiliation: a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Keino
authors.affiliation: a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .
authors.forename: Annabelle A
authors.initials: AA
authors.lastname: Okada
authors.affiliation: a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .
authors.forename: Takayo
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: b Department of Ophthalmology , St. Lukes International Hospital , Tokyo , Japan .
authors.forename: Nariaki
authors.initials: N
authors.lastname: Echizen
authors.affiliation: a Department of Ophthalmology , Kyorin University School of Medicine , Tokyo , Japan .
authors.forename: Makoto
authors.initials: M
authors.lastname: Inoue
authors.affiliation: c Second Department of Internal Medicine , Kyorin University School of Medicine , Tokyo , Japan , and.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takayama
authors.affiliation: d Department of Neurosurgery , Kyorin University School of Medicine , Tokyo , Japan.
authors.forename: Motoo
authors.initials: M
authors.lastname: Nagane
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D001706:Biopsy; D005134:Eye Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D005451:Fluorescein Angiography; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D058449:Intravitreal Injections; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D055213:Retinal Pigment Epithelium / Q000000981:diagnostic imaging* / Q000378:metabolism; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014822:Vitreous Body / Q000000981:diagnostic imaging* / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D014408:Biomarkers, Tumor; C508609:IL10 protein, human; C508600:IL6 protein, human; D007143:Immunoglobulin Heavy Chains; D015850:Interleukin-6; D016753:Interleukin-10; D008727:Methotrexate
keywords: Intraocular lymphoma; spectral domain optical coherence tomography