title: n-3 Polyunsaturated fatty acids and mast cell activation.
abstract: Mast cells are known to play a vital role in the development of inflammation in allergic responses. Recent studies have indicated that mast cell activation could be modulated by n-3 PUFAs, which have a wide range of well-documented health benefits. In our review, we summarize the recent findings and potential mechanisms of the effect of n-3 PUFAs on mast cell activation. This knowledge could provide new strategies for the development of therapeutic interventions for diseases mediated by mast cells.
authors.affiliation: *Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada; and National Research Council Canada, National Institute for Nanotechnology, Edmonton, Alberta, Canada.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Wang
authors.affiliation: *Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada; and Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada; and National Research Council Canada, National Institute for Nanotechnology, Edmonton, Alberta, Canada marianna.kulka@nrc-cnrc.gc.ca.
authors.forename: Marianna
authors.initials: M
authors.lastname: Kulka
keywords: DHA; EPA; FcεRI; eicosanoid; lipid rafts