title: Practical molecular pathologic diagnosis of infiltrating gliomas.
abstract: Recent advances in molecular diagnostics have led to better understanding of glioma tumorigenesis and biology. Numerous glioma biomarkers with diagnostic, prognostic, and predictive value have been identified. Although some of these markers are already part of the routine clinical management of glioma patients, data regarding others are limited and difficult to apply routinely. In addition, multiple methods for molecular subclassification have been proposed either together with or as an alternative to the current morphologic classification and grading scheme. This article reviews the literature regarding glioma biomarkers and offers a few practical suggestions.
authors.affiliation: Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Avenue, #M551, Box 0102, San Francisco, CA 94143, USA.
authors.forename: Melike
authors.initials: M
authors.lastname: Pekmezci
authors.affiliation: Division of Neuropathology, Department of Pathology, University of California, San Francisco, 505 Parnassus Avenue, #M551, Box 0102, San Francisco, CA 94143, USA; Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: Arie.Perry@ucsf.edu.
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
mesh_terms: D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology*; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D004268:DNA-Binding Proteins / Q000235:genetics; D066246:ErbB Receptors / Q000235:genetics; D019942:Genes, p16; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006657:Histones / Q000235:genetics; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D009154:Mutation; D051059:PTEN Phosphohydrolase / Q000235:genetics; D019098:Telomerase / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D006657:Histones; C114495:TP53TG1 protein, human; D007521:Isocitrate Dehydrogenase; D066246:ErbB Receptors; D019098:Telomerase; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: Alternative lengthening of telomeres; Epidermal growth factor receptor; Epigenetic; Genetic; Glioma; Infiltrating glioma; Isocitrate dehydrogenase; Molecular