title: The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis.
abstract: BACKGROUND
  The role of human papillomavirus (HPV) in the development of esophageal cancer remains controversial. Our study aims to test the association between HPV 16 infection and esophageal cancer in China, providing useful information on this unclear association in Chinese population.
  
  
  METHODS
  Studies on HPV infection and esophageal cancer were identified. A random-effects model was used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) comparing cases with controls.
  
  
  RESULTS
  A total of 1442 esophageal cancer cases and 1602 controls from 10 included studies were evaluated to estimate the association between HPV 16 infection and esophageal cancer risk. The ORs for each case-control studies ranged from 3.65 (95% CI: 2.17, 6.13) to 15.44 (95% CI: 3.42, 69.70). The pooled estimates for OR was 6.36 (95% CI: 4.46, 9.07). In sensitivity analysis, the estimates for OR ranged from 5.92 (95% CI: 4.08, 8.60) to 6.97 (95% CI: 4.89, 9.93).
  
  
  CONCLUSIONS
  This study indicates that HPV-16 infection may be a risk factor for esophageal cancer among Chinese population, supporting an etiological role of HPV16 in this malignancy. Results in this study may have important implications for esophageal cancer prevention and treatment in China.
authors.affiliation: Department of Cancer Epidemiology, Henan Cancer Hospital, Henan Office for Cancer Control and Research, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China, shaokaizhang@126.com.
authors.forename: Shao-Kai
authors.initials: SK
authors.lastname: Zhang
authors.forename: Lan-Wei
authors.initials: LW
authors.lastname: Guo
authors.forename: Qiong
authors.initials: Q
authors.lastname: Chen
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Liu
authors.forename: Pei-Liang
authors.initials: PL
authors.lastname: Quan
authors.forename: Jian-Bang
authors.initials: JB
authors.lastname: Lu
authors.forename: Xi-Bin
authors.initials: XB
authors.lastname: Sun
mesh_terms: D044466:Asian People / Q000208:ethnology; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000821:virology*; D005260:Female; D005838:Genotype; D052162:Human papillomavirus 16 / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D030361:Papillomavirus Infections / Q000208:ethnology / Q000821:virology*