title: Characterisation of Elastic and Acoustic Properties of an Agar-Based Tissue Mimicking Material.
abstract: As a first step towards an acoustic localisation device for coronary stenosis to provide a non-invasive means of diagnosing arterial disease, measurements are reported for an agar-based tissue mimicking material (TMM) of the shear wave propagation velocity, attenuation and viscoelastic constants, together with one dimensional quasi-static elastic moduli and Poisson's ratio. Phase velocity and attenuation coefficients, determined by generating and detecting shear waves piezo-electrically in the range 300 Hz-2 kHz, were 3.2-7.5 ms(-1) and 320 dBm(-1). Quasi-static Young's modulus, shear modulus and Poisson's ratio, obtained by compressive or shear loading of cylindrical specimens were 150-160 kPa; 54-56 kPa and 0.37-0.44. The dynamic Young's and shear moduli, derived from fitting viscoelastic internal variables by an iterative statistical inverse solver to freely oscillating specimens were 230 and 33 kPa and the corresponding relaxation times, 0.046 and 0.036 s. The results were self-consistent, repeatable and provide baseline data required for the computational modelling of wave propagation in a phantom.
authors.affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. mark.brewin@salisbury.nhs.uk.
authors.forename: M P
authors.initials: MP
authors.lastname: Brewin
authors.affiliation: Clinical Physics, Barts Health NHS Trust, 56-76 Ashfield Street, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Birch
authors.affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Mehta
authors.affiliation: Clinical Physics, Barts Health NHS Trust, 56-76 Ashfield Street, London, UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Reeves
authors.affiliation: BICOM (Brunel Institute of Computational Mathematics) and Mathematics, Brunel University, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.affiliation: BICOM (Brunel Institute of Computational Mathematics) and Mathematics, Brunel University, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Kruse
authors.affiliation: BICOM (Brunel Institute of Computational Mathematics) and Mathematics, Brunel University, London, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Whiteman
authors.affiliation: Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.affiliation: Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC, USA.
authors.forename: Z R
authors.initials: ZR
authors.lastname: Kenz
authors.affiliation: Center for Research in Scientific Computation, North Carolina State University, Raleigh, NC, USA.
authors.forename: H T
authors.initials: HT
authors.lastname: Banks
authors.affiliation: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. s.e.greenwald@qmul.ac.uk.
authors.forename: S E
authors.initials: SE
authors.lastname: Greenwald
mesh_terms: D000362:Agar / Q000737:chemistry*; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D055119:Elastic Modulus; D006801:Humans; D019047:Phantoms, Imaging; D014463:Ultrasonography
chemical_list: D000362:Agar
keywords: Acoustic localisation; Acoustic properties; Coronary artery; Elastic moduli; Poisson’s ratio; Shear modulus; Shear wave; Stenosis; Tissue mimicking material; Viscoelasticity