title: Meta-analysis of methylenetetrahydrofolate reductase polymorphism and lung cancer risk in Chinese.
abstract: Numerous studies have investigated association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with lung cancer (LC) susceptibility in Chinese; however, the findings are inconsistent. Therefore, we performed a meta-analysis. PubMed, ISI Web of Knowledge, Chinese National Knowledge Infrastructure, and Wanfang were searched. Pooled ORs and 95% CIs were used to assess the strength of the associations. Overall, 10 studies with 2487 cases and 3228 controls investigating the MTHFR C677T polymorphism and LC risk were included. We did not find a significant association between MTHFR C677T polymorphism and LC risk. However, significantly increased LC risk was found in the population from North China, which was not found in the population from South China. In conclusion, our meta-analysis suggested that MTHFR C677T polymorphism might influence the risk of LC.
authors.affiliation: Department of Cardiology, Thoracic Surgery, Nanyang Central Hospital of Henan Province Nanyang 473000, Henan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Tumor Three Wards, Nanyang Central Hospital of Henan Province, Nanyang Central Hospital of Henan Province Nanyang 473000, Henan, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yue
authors.affiliation: Anesthesiology, Nanyang City Orthopaedic Hospital of Henan Province Nanyang 473002, Henan, China.
authors.forename: Liran
authors.initials: L
authors.lastname: Hao
keywords: Lung cancer; MTHFR; meta-analysis; polymorphism