title: Cross-modality PET/CT and contrast-enhanced CT imaging for pancreatic cancer.
abstract: OBJECTIVE
  To explore the diagnostic value of the cross-modality fusion images provided by positron emission tomography/computed tomography (PET/CT) and contrast-enhanced CT (CECT) for pancreatic cancer (PC).
  
  
  METHODS
  Data from 70 patients with pancreatic lesions who underwent CECT and PET/CT examinations at our hospital from August 2010 to October 2012 were analyzed. PET/CECT for the cross-modality image fusion was obtained using TureD software. The diagnostic efficiencies of PET/CT, CECT and PET/CECT were calculated and compared with each other using a χ(2) test. P < 0.05 was considered to indicate statistical significance.
  
  
  RESULTS
  Of the total 70 patients, 50 had PC and 20 had benign lesions. The differences in the sensitivity, negative predictive value (NPV), and accuracy between CECT and PET/CECT in detecting PC were statistically significant (P < 0.05 for each). In 15 of the 31 patients with PC who underwent a surgical operation, peripancreatic vessel invasion was verified. The differences in the sensitivity, positive predictive value, NPV, and accuracy of CECT vs PET/CT and PET/CECT vs PET/CT in diagnosing peripancreatic vessel invasion were statistically significant (P < 0.05 for each). In 19 of the 31 patients with PC who underwent a surgical operation, regional lymph node metastasis was verified by postsurgical histology. There was no statistically significant difference among the three methods in detecting regional lymph node metastasis (P > 0.05 for each). In 17 of the 50 patients with PC confirmed by histology or clinical follow-up, distant metastasis was confirmed. The differences in the sensitivity and NPV between CECT and PET/CECT in detecting distant metastasis were statistically significant (P < 0.05 for each).
  
  
  CONCLUSIONS
  Cross-modality image fusion of PET/CT and CECT is a convenient and effective method that can be used to diagnose and stage PC, compensating for the defects of PET/CT and CECT when they are conducted individually.
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Chang-Jing
authors.initials: CJ
authors.lastname: Zuo
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Ning-Yang
authors.initials: NY
authors.lastname: Jia
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Sheng-Ping
authors.initials: SP
authors.lastname: Hu
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Zhong-Fei
authors.initials: ZF
authors.lastname: Yu
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: An-Yu
authors.initials: AY
authors.lastname: Zhang
authors.affiliation: Jian Zhang, Chang-Jing Zuo, Sheng-Ping Hu, An-Yu Zhang, Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Feng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D064847:Multimodal Imaging / Q000379:methods*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media
keywords: Contrast enhancement; Diagnostic imaging; Pancreatic neoplasms; Positron-emission tomography; Staging; Tomography, X-ray computed