title: N-acetylcysteine treats intravenous amiodarone induced liver injury.
abstract: We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.
authors.affiliation: Matthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Mudalel
authors.affiliation: Matthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
authors.forename: Kartikeya P
authors.initials: KP
authors.lastname: Dave
authors.affiliation: Matthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
authors.forename: James P
authors.initials: JP
authors.lastname: Hummel
authors.affiliation: Matthew L Mudalel, Steven F Solga, Department of Medicine, Division of Gastroenteorlogy, St. Luke's University Hospital and Temple School of Medicine, Bethlehem, PA 18015, United States.
authors.forename: Steven F
authors.initials: SF
authors.lastname: Solga
mesh_terms: D000111:Acetylcysteine / Q000008:administration & dosage*; D000368:Aged; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000975:Antioxidants / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D018384:Oxidative Stress / Q000187:drug effects; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D015415:Biomarkers; D000638:Amiodarone; D000111:Acetylcysteine
keywords: Amiodarone; Drug induced liver injury; Liver enzymes; N-acetylcysteine; Pathogenesis