title: Ocular metastasis of colorectal cancer: An uncommon presentation of a common malignancy.
abstract: Approximately 20% of patients with colorectal cancer have metastatic disease at time of diagnosis, and another 25-35% develop metastases during the course of their disease. Liver, peritoneum, and lungs are the most common sites of metastases. We report the case of a 60-year-old female who presented with ocular metastasis 4 years after her initial curative-intent treatment for T3N1M0 rectal adenocarcinoma. After local eye radiation therapy, she received palliative systemic chemotherapy and enjoyed a good quality of life for 32 months before succumbing to progressive disease. Ocular metastasis of colorectal cancer is rare. When present, it usually occurs in the setting of diffuse hematogenous spread. In addition to local therapy, systemic chemotherapy should also be considered.
authors.affiliation: Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Muhammad Rizwan
authors.initials: MR
authors.lastname: Khawaja
authors.affiliation: Midwest Eye Institute, Indianapolis, IN, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Minturn
authors.affiliation: Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: A John
authors.initials: AJ
authors.lastname: Spittler
authors.affiliation: Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA; University of Washington, Seattle, WA, USA. Electronic address: gchiorea@uw.edu.
authors.forename: E Gabriela
authors.initials: EG
authors.lastname: Chiorean
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D005123:Eye / Q000000981:diagnostic imaging; D005134:Eye Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
keywords: Colorectal cancer; Ocular metastasis