title: [Clinopahological analysis of sinonasal mucosal malignant melanoma].
abstract: OBJECTIVE
  To investigate the clinopathological characteristics, differential diagnosis, therapy and prognosis of sinonasal mucosal malignant melanoma.
  
  
  METHODS
  Clinopathological data of 18 cases which were diagnosed by pathology and immmunohistochemistry were analyzed retrospectively. All cases were proved by pathology and immmunohistochemistry. All cases were performed operations. 5 underwent single surgery. 4 underwent surgery plus adjuvant radiotherapy. 4 underwent surgery plus adjuvant radiotherapy chemotherapy. 5 underwent surgery plus adjuvant chemoradiation.
  
  
  RESULTS
  All cases were followed up for a period of 1 to 7 years after operation. Twelve patients died of tumor until the last follow-up, meanwhile 6 patients stayed alive. In Six cases recurrence occurred. In five casescervical lymph node metastasis occurred, of which 3 cases received neck dissection and 2 cases received chemotherapy and radiotherapy due to no surgical indications. In three cases distant metastasis oc- curred.
  
  
  CONCLUSIONS
  Sinonasal mucosal malignant melanoma is rare and highly heterogenous. Current diagnosis depends on clinical characteristics and immunohistochemical examination. It still should be differentially diagnosed from other tumors. CT and MRI image examination can provide some helpful information to understand the extent and nature of lesions. The treatment of nasal endoscopic or the surgery under endoscopy has become to be a safe, viable and reasonable alternative to open resection. Appropriate indication must be carefully selected for these lesions.
authors.forename: Qingjia
authors.initials: Q
authors.lastname: Gu
authors.forename: Gang
authors.initials: G
authors.lastname: He
authors.forename: Jingxian
authors.initials: J
authors.lastname: Li
authors.forename: Jiagang
authors.initials: J
authors.lastname: Fan
authors.forename: Debing
authors.initials: D
authors.lastname: Li
authors.forename: Libing
authors.initials: L
authors.lastname: Zhao
authors.forename: Linhong
authors.initials: L
authors.lastname: Song
mesh_terms: D017024:Chemotherapy, Adjuvant; D004724:Endoscopy; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009092:Mucous Membrane; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies