title: Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis.
abstract: Impaired hemostasis frequently occurs after traumatic shock and resuscitation. The prehospital fluid administered can exacerbate subsequent bleeding and coagulopathy. Hypertonic solutions are recommended as first-line treatment of traumatic shock; however, their effects on coagulation are unclear. This study explores the impact of resuscitation with various hypertonic solutions on early coagulopathy after trauma. We conducted a prospective observational subgroup analysis of large clinical trial on out-of-hospital single-bolus (250 mL) hypertonic fluid resuscitation of hemorrhagic shock trauma patients (systolic blood pressure, ≤70 mmHg). Patients received 7.5% NaCl (HS), 7.5% NaCl/6% Dextran 70 (HSD), or 0.9% NaCl (normal saline [NS]) in the prehospital setting. Thirty-four patients were included: 9 HS, 8 HSD, 17 NS. Treatment with HS/HSD led to higher admission systolic blood pressure, sodium, chloride, and osmolarity, whereas lactate, base deficit, fluid requirement, and hemoglobin levels were similar in all groups. The HSD-resuscitated patients had higher admission international normalized ratio values and more hypocoagulable patients, 62% (vs. 55% HS, 47% NS; P < 0.05). Prothrombotic tissue factor was elevated in shock treated with NS but depressed in both HS and HSD groups. Fibrinolytic tissue plasminogen activator and anti-fibrinolytic plasminogen activator inhibitor type 1 were increased by shock but not thrombin-activatable fibrinolysis inhibitor. The HSD patients had the worst imbalance between procoagulation/anticoagulation and profibrinolysis/antifibrinolysis, resulting in more hypocoagulability and hyperfibrinolysis. We concluded that resuscitation with hypertonic solutions, particularly HSD, worsens hypocoagulability and hyperfibrinolysis after hemorrhagic shock in trauma through imbalances in both procoagulants and anticoagulants and both profibrinolytic and antifibrinolytic activities.
authors.affiliation: *Department of Surgery, Division of Acute Care Surgery, University of Michigan, Ann Arbor, Michigan; †American College of Surgeons, Department of Surgery, University of California, Irvine, California; ‡Department of Surgery and Critical Care Medicine, St. Michael's Hospital, and §Defence Research and Development Canada Toronto, University of Toronto, Toronto, Ontario, Canada; ∥Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington; ¶Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; **Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; and ††US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Delano
authors.forename: Sandro B
authors.initials: SB
authors.lastname: Rizoli
authors.forename: Shawn G
authors.initials: SG
authors.lastname: Rhind
authors.forename: Joseph
authors.initials: J
authors.lastname: Cuschieri
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Junger
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Baker
authors.forename: Michael A
authors.initials: MA
authors.lastname: Dubick
authors.forename: David B
authors.initials: DB
authors.lastname: Hoyt
authors.forename: Eileen M
authors.initials: EM
authors.lastname: Bulger
mesh_terms: D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D004632:Emergency Medical Services; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012151:Resuscitation / Q000009:adverse effects*; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D006982:Hypertonic Solutions