title: The antifungal activity of Artemisia sieberi essential oil from different localities of Iran against dermatophyte fungi.
abstract: Dermatophyte fungi are the most common cause of dermatophytosis in humans and animals. Artemisia sieberi is traditionally used for treatment of fungi related skin infections. In this investigation, we analyzed five samples of A. sieberi oils (different harvesting times and distinctive collecting locations) by GC-FID and GC-MS. The antifungal activities of A. sieberi oils were evaluated against different dermatophytes. The anti-elastase activities of essential oils were also evaluated. The results of analysis showed that the harvesting time and collecting location can affect the chemical compositions and oil yields. The best time for collecting the A. sieberi with high yield was spring season (January-February). There was no significant difference between the desirable anti-dermatophyte activities of A. sieberi oils with different chemical compositions. M. gypseum, T. rubrum and M. canis had more sensitivity than others to A. sieberi oils. The oils with higher amounts of α-thujone, β-thujone showed the higher anti-elastase activity. Therefore, A. sieberi can be used as topical antifungal agent for treatment of skin dermatophyte infections.
authors.affiliation: Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran. Electronic address: mahboubi1357@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Mahboubi
authors.affiliation: Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Kazempour
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000254:growth & development; D000081008:Bicyclic Monoterpenes; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007492:Iran; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology; D014005:Tinea / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; C005790:beta-thujone
keywords: Agent antifongique; Antifungal agent; Artemisia sieberi; Dermatophyte fungi; Dermatophytes; Elastase; Élastase