title: Effect of geumgoeshingi-whan pharmacopuncture on the blood pressure in spontaneously hypertensive rats.
abstract: OBJECTIVE
  The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR).
  
  
  METHODS
  SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks.
  
  
  RESULTS
  The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP).
  
  
  CONCLUSIONS
  These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.
authors.affiliation: Pusan National University School of Korean Medicine, Yangsan, Korea.
authors.forename: Meesun
authors.initials: M
authors.lastname: Lee
authors.affiliation: WUGOH ALS Center of Wonkwang University, Gwangju, Korea.
authors.forename: Sangmi
authors.initials: S
authors.lastname: Lee
authors.affiliation: WUGOH ALS Center of Wonkwang University, Gwangju, Korea.
authors.forename: Hohyn
authors.initials: H
authors.lastname: Jeong
authors.affiliation: WUGOH ALS Center of Wonkwang University, Gwangju, Korea.
authors.forename: Manyong
authors.initials: M
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital, Gwanju, Korea.
authors.forename: Dong-Woung
authors.initials: DW
authors.lastname: Kim
authors.affiliation: Department of Oriental Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital, Gwanju, Korea.
authors.forename: Bong-Keun
authors.initials: BK
authors.lastname: Song
authors.affiliation: Department of Radiology, Wonkwang University College of Korean Medicine, Iksan, Korea.
authors.forename: Jong-Deok
authors.initials: JD
authors.lastname: Lee
authors.affiliation: Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Korea.
authors.forename: Ho Sub
authors.initials: HS
authors.lastname: Lee
authors.affiliation: WUGOH ALS Center of Wonkwang University, Gwangju, Korea ; Department of Acupuncture & Moxibustion, Wonkwang Gwangju Oriental Medical Hospital, Gwanju, Korea.
authors.forename: Sungchul
authors.initials: S
authors.lastname: Kim
keywords: ANP; Geumgoeshingi-whan; Pharmacopuncture; Renal function; SHR; hypertension