title: [Functional disorders of the gastrointestinal tract in the context of morphofunctional unity].
abstract: The aim of this work was systematization of the currently available data on pathological physiology and morphology of functional disorders of the gastrointestinal tract (GIT) underlain by combined changes of neuroendocrine and neural regulation related to genetic polymorphism and external provoking factors (in the first place, stress). Altered function and morphology of diffuse neuroendocrine system and expression of certain regulatory molecules (nitric oxide, interleukin-1) in the patients with functional GIT disorders induce inflammation and changes in epitheliocyte regeneration, i.e. morphological substrate of the disease. Verification of various morphofunctional and structural changes accompanying functional pathology of GIT necessitates further improvement of classification criteria for functional diseases as reflected in the forthcoming Rome criteria IV.
authors.forename: M A
authors.initials: MA
authors.lastname: Osadchuk
authors.forename: A M
authors.initials: AM
authors.lastname: Osadchuk
authors.forename: S N
authors.initials: SN
authors.lastname: Nikolenko
mesh_terms: D017615:Enteric Nervous System / Q000378:metabolism / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000294:innervation / Q000473:pathology / Q000503:physiopathology; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009490:Neurosecretory Systems / Q000503:physiopathology*