title: [BIS values were useful on the evaluation of consciousness recovery in acute Vegetamin-A poisoning: report of a case].
abstract: A 37-year-old man was admitted to our hospital with acute phenobarbital poisoning. On arrival, he was in deep coma with respiro-circulatory depressions. The serum concentration of the agent was elevated to 149.04 μg/mL which was consistent with a lethal concentration level. He underwent a gastric lavage, administration of activated charcoal, urinary alkalinazation and bowel irrigation. Respiro-circulatory status was recovered rapidly, while the serum concentration of phenobarbital did not decrease smoothly. Although the concentration of the agent decreased to 77.07 μg/mL that should be a comatose level, BIS values were gradually elevated, and then eventually the patient regained his consciousness. Because he was a chronic user of Vegetamin-A containing phenobarbital, the serum level might not have been correlated with symptoms. BIS values were highly reflective of the consciousness level, so it could be a useful indicator for predicting the consciousness levels of patients in deep coma with acute poisoning from hypnotic agents.
authors.forename: Hironori
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Kensuke
authors.initials: K
authors.lastname: Umakoshi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Takeba
authors.forename: Mayuki
authors.initials: M
authors.lastname: Aibiki
mesh_terms: D000208:Acute Disease; D000328:Adult; D002606:Charcoal / Q000008:administration & dosage; D002746:Chlorpromazine / Q000097:blood / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D056805:Consciousness Monitors; D004338:Drug Combinations; D004733:Enema; D005751:Gastric Lavage; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood / Q000506:poisoning*; D008297:Male; D010634:Phenobarbital / Q000097:blood / Q000506:poisoning*; D020127:Recovery of Function; D013607:Tablets; D016896:Treatment Outcome; D014474:Unconsciousness / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy
chemical_list: D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D013607:Tablets; C515390:vegetamin; D002606:Charcoal; D002746:Chlorpromazine; D010634:Phenobarbital