title: Clinical Review: Familial Mediterranean Fever-An Overview of Pathogenesis, Symptoms, Ocular Manifestations, and Treatment.
abstract: Familial Mediterranean fever is an autoinflammatory multisystem disease, which most commonly affects patients from the Mediterranean basin. This review discusses the common polymorphisms in the MEFV gene as well as the role of pyrin in disease pathogenesis. Patients with familial Mediterranean fever typically develop peritonitis, pleuritis, arthritis, and fever. In addition, a number of authors have reported ophthalmic features. These case reports and series are further explored in this review. Colchicine has transformed the prognosis for patients with familial Mediterranean fever. The rationale for the use of colchicine, as well as the evidence for newer biologic agents is also covered.
authors.affiliation: a Clinical and Diagnostic Oral Sciences, Queen Mary University of London , London , UK .
authors.forename: Harry
authors.initials: H
authors.lastname: Petrushkin
authors.affiliation: b Medical Eye Unit , St Thomas' Hospital , London , UK , and.
authors.forename: Miles
authors.initials: M
authors.lastname: Stanford
authors.affiliation: a Clinical and Diagnostic Oral Sciences, Queen Mary University of London , London , UK .
authors.forename: Farida
authors.initials: F
authors.lastname: Fortune
authors.affiliation: c Rheumatology Department , Royal London Hospital , London , UK.
authors.forename: Ali S
authors.initials: AS
authors.lastname: Jawad
mesh_terms: D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000209:etiology / Q000235:genetics / Q000628:therapy; D006801:Humans; D009154:Mutation; D000071198:Pyrin / Q000235:genetics; D050257:Tubulin Modulators / Q000627:therapeutic use; D014605:Uveitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: C000604192:MEFV protein, human; D000071198:Pyrin; D050257:Tubulin Modulators; D003078:Colchicine
keywords: Eye; FMF; familial Mediterranean fever; ocular; ophthalmic; uveitis