title: Hydrogen sulfide regulates inward-rectifying K+ channels in conjunction with stomatal closure.
abstract: Hydrogen sulfide (H2S) is the third biological gasotransmitter, and in animals, it affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse physiological responses. H2S closes stomata, but the underlying mechanism remains elusive. Here, we report the selective inactivation of current carried by inward-rectifying K(+) channels of tobacco (Nicotiana tabacum) guard cells and show its close parallel with stomatal closure evoked by submicromolar concentrations of H2S. Experiments to scavenge H2S suggested an effect that is separable from that of abscisic acid, which is associated with water stress. Thus, H2S seems to define a unique and unresolved signaling pathway that selectively targets inward-rectifying K(+) channels.
authors.affiliation: Laboratory of Plant Physiology and Biophysics, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom (M.P., M.R.B.); andInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, 7600 Mar del Plata, Argentina (D.S., C.G.-M.).
authors.forename: Maria
authors.initials: M
authors.lastname: Papanatsiou
authors.affiliation: Laboratory of Plant Physiology and Biophysics, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom (M.P., M.R.B.); andInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, 7600 Mar del Plata, Argentina (D.S., C.G.-M.).
authors.forename: Denisse
authors.initials: D
authors.lastname: Scuffi
authors.affiliation: Laboratory of Plant Physiology and Biophysics, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom (M.P., M.R.B.); andInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, 7600 Mar del Plata, Argentina (D.S., C.G.-M.) michael.blatt@glasgow.ac.uk.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Blatt
authors.affiliation: Laboratory of Plant Physiology and Biophysics, Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow G12 8QQ, United Kingdom (M.P., M.R.B.); andInstituto de Investigaciones Biológicas, Universidad Nacional de Mar del Plata, Consejo Nacional de Investigaciones Científicas y Técnicas, 7600 Mar del Plata, Argentina (D.S., C.G.-M.).
authors.forename: Carlos
authors.initials: C
authors.lastname: García-Mata
mesh_terms: D000040:Abscisic Acid / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D006862:Hydrogen Sulfide / Q000494:pharmacology*; D015640:Ion Channel Gating / Q000187:drug effects; D054046:Plant Stomata / Q000187:drug effects / Q000502:physiology*; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism*; D014026:Nicotiana / Q000187:drug effects / Q000502:physiology
chemical_list: D024661:Potassium Channels, Inwardly Rectifying; D000040:Abscisic Acid; D002118:Calcium; D006862:Hydrogen Sulfide