title: Transformation of catalytic characteristics of cerebral monoamine oxidases in experimental posttraumatic stress disorders.
abstract: We studied the contribution of the transformation of the catalytic properties of cerebral monoamine oxidase in the development of behavioral disorders during stress. Monoamine oxidase activities and catalytic characteristics, LPO intensity, and oxidative modification of proteins in suspension of the brain mitochondria were evaluated over the course of experimental posttraumatic stress disorder. The detected shifts were comparable with the results of neuroethologic testing. The development of behavioral disorders presented by low exploratory activity and high anxiety was associated with transformation of catalytic characteristics of cerebral monoamine oxidases, associated with the development of oxidative stress with predominant intensification of metal-catalyzed protein oxidation.
authors.affiliation: Research Center of Family Health and Human Reproduction Problems, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.forename: A S
authors.initials: AS
authors.lastname: Popova
authors.forename: R V
authors.initials: RV
authors.lastname: Deev
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitskii
authors.forename: L I
authors.initials: LI
authors.lastname: Krupitskaya
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002384:Catalysis; D054022:Cerebrum / Q000201:enzymology*; D005609:Free Radicals / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D008995:Monoamine Oxidase