title: DNA-templated in situ growth of AgNPs on SWNTs: a new approach for highly sensitive SERS assay of microRNA.
abstract: In this communication, we find that the single-walled carbon nanotubes (SWNTs) can demonstrate an excellent ssDNA concentration-dependent surface enhanced Raman scattering (SERS) effect after the decoration of DNA-templated in situ grown AgNPs on the surface. Inspired by this, the SWNT@AgNPs hybrid nanocomposite was employed to achieve microRNA detection which is also sensitive to crude extraction from human breast cancer cells and even patient tissues before and after chemotherapy.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Yangrh@pku.ed.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Zheng
authors.forename: Junhui
authors.initials: J
authors.lastname: Bai
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhou
authors.forename: Jishan
authors.initials: J
authors.lastname: Li
authors.forename: Yinhui
authors.initials: Y
authors.lastname: Li
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Yang
authors.forename: Ronghua
authors.initials: R
authors.lastname: Yang
mesh_terms: D004277:DNA, Single-Stranded / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry; D035683:MicroRNAs / Q000032:analysis* / Q000737:chemistry; D008958:Models, Molecular; D036103:Nanotechnology / Q000379:methods*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman
chemical_list: D004277:DNA, Single-Stranded; D035683:MicroRNAs; D037742:Nanotubes, Carbon; D012834:Silver