title: Theranostic Radiopharmaceuticals Based on Gold Nanoparticles Labeled with (177)Lu and Conjugated to Peptides.
abstract: Gold nanoparticles (AuNPs) have been proposed for a variety of medical applications such as localized heat sources for cancer treatment and drug delivery systems. The conjugation of peptides to AuNPs produces stable multimeric systems with target-specific molecular recognition. Lutetium- 177 ((177)Lu) has been successfully used in peptide radionuclide therapy. Recently, (177)Lu-AuNPs conjugated to different peptides have been proposed as a new class of theranostic radiopharmaceuticals. These radioconjugates may function simultaneously as molecular imaging agents, radiotherapy systems and thermal-ablation systems. This article covers advancements in the design, synthesis, physicochemical characterization, molecular recognition assessment and preclinical therapeutic efficacy of gold nanoparticles radiolabeled with (177)Lu and conjugated to RGD (-Arg-Gly-Asp-), Lys(3)-Bombesin and Tat(49-57) peptides.
authors.affiliation: Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N. La Marquesa, Ocoyoacac, Estado de México, C.P. 52750, México. guillermina.ferro@inin.gob.mx.
authors.forename: Guillermina
authors.initials: G
authors.lastname: Ferro-Flores
authors.forename: Blanca E
authors.initials: BE
authors.lastname: Ocampo-García
authors.forename: Clara L
authors.initials: CL
authors.lastname: Santos-Cuevas
authors.forename: Flor
authors.initials: F
authors.lastname: de María Ramírez
authors.forename: Erika P
authors.initials: EP
authors.lastname: Azorín-Vega
authors.forename: Laura
authors.initials: L
authors.lastname: Meléndez-Alafort
mesh_terms: D016503:Drug Delivery Systems; D015195:Drug Design; D006046:Gold / Q000737:chemistry; D006801:Humans; D008187:Lutetium / Q000008:administration & dosage / Q000737:chemistry*; D053768:Metal Nanoparticles; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry; D011868:Radioisotopes / Q000008:administration & dosage / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D010455:Peptides; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D008187:Lutetium; D006046:Gold