title: MRI visible drug eluting magnetic microspheres for transcatheter intra-arterial delivery to liver tumors.
abstract: Magnetic resonance imaging (MRI)-visible amonafide-eluting alginate microspheres were developed for targeted arterial-infusion chemotherapy. These alginate microspheres were synthesized using a highly efficient microfluidic gelation process. The microspheres included magnetic clusters formed by USPIO nanoparticles to permit MRI and a sustained drug-release profile. The biocompatibility, MR imaging properties and amonafide release kinetics of these microspheres were investigated during in vitro studies. A xenograft rodent model was used to demonstrate the feasibility to deliver these microspheres to liver tumors using hepatic transcatheter intra-arterial infusions and potential to visualize the intra-hepatic delivery of these microspheres to both liver tumor and normal tissues with MRI immediately after infusion. This approach offer the potential for catheter-directed drug delivery to liver tumors for reduced systemic toxicity and superior therapeutic outcomes.
authors.affiliation: 1. Department of Radiology, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.affiliation: 2. Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Jeane
authors.initials: J
authors.lastname: Chen
authors.affiliation: 3. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Reed A
authors.initials: RA
authors.lastname: Omary
authors.affiliation: 4. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA; Department of Electrical Engineering and Computer Science, Evanston, IL, USA; International Institute of Nanotechnology (IIN), Northwestern University, Evanston, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA. Department of Radiology, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larson
mesh_terms: D000225:Adenine; D000464:Alginates / Q000008:administration & dosage / Q000032:analysis; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000032:analysis; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000032:analysis; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008863:Microspheres; D053644:Naphthalimides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D063065:Organophosphonates; D051381:Rats
chemical_list: D000464:Alginates; D000970:Antineoplastic Agents; D004337:Drug Carriers; D006603:Hexuronic Acids; D053644:Naphthalimides; D063065:Organophosphonates; C037020:amonafide; D020723:Glucuronic Acid; D000225:Adenine
keywords: MRI; liver tumors; microspheres