title: Chitin, chitosan, and its derivatives for wound healing: old and new materials.
abstract: Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. kazu-azuma@muses.tottori-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. jastam0ment@gmail.com.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Izumi
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. tosaki@muses.tottori-u.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. sifuku@chem.tottori-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
authors.affiliation: Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, 4-101 Koyama-minami, Tottori 680-8550, Japan. morimoro@chem.tottori-u.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Graduate School of Engineering, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. saimoto@chem.tottori-u.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. saburominami@ncn-t.net.
authors.forename: Saburo
authors.initials: S
authors.lastname: Minami
authors.affiliation: Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University, 4-101 Koyama-minami, Tottori 680-8553, Japan. yokamoto@muses.tottori-u.ac.jp.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto