title: Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes.
abstract: There is evidence that betatrophin, a hormone derived from adipose tissue and liver, affects the proliferation of pancreatic beta cells in mice. The aim of this study was to examine circulating betatrophin concentrations in Japanese healthy controls and patients with type 1 and type 2 diabetes. A total of 76 subjects (12 healthy controls, 34 type 1 diabetes, 30 type 2 diabetes) were enrolled in the study. Circulating betatrophin was measured with an ELISA kit and clinical parameters related to betatrophin were analyzed statistically. Circulating betatrophin (Log transformed) was significantly increased in patients with diabetes compared with healthy subjects (healthy controls, 2.29 ± 0.51; type 1 diabetes, 2.94 ± 0.44; type 2 diabetes, 3.17 ± 0.18; p<0.001, 4.1 to 5.4 times in pg/mL order). Age, HbA1c, fasting plasma glucose and Log triglyceride were strongly associated with Log betatrophin in all subjects (n=76) in correlation analysis. In type 1 diabetes, there was a correlation between Log betatrophin and Log CPR. These results provide the first evidence that circulating betatrophin is significantly elevated in Japanese patients with diabetes. The findings of this pilot study also suggest a possibility of association between the level of betatrophin and the levels of glucose and triglycerides.
authors.affiliation: Division of Endocrinology and Metabolism, Jichi Medical University Saitama Medical Center, Saitama 330-8503 Japan.
authors.forename: Hodaka
authors.initials: H
authors.lastname: Yamada
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
authors.forename: Atsushi
authors.initials: A
authors.lastname: Aoki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Asano
authors.forename: Masashi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Aki
authors.initials: A
authors.lastname: Ikoma
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Kusaka
authors.forename: Hideo
authors.initials: H
authors.lastname: Toyoshima
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kakei
authors.forename: San-E
authors.initials: SE
authors.lastname: Ishikawa
mesh_terms: D000328:Adult; D000368:Aged; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005215:Fasting; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001786:Blood Glucose; D002096:C-Peptide; D008076:Cholesterol, HDL; D006442:Glycated Hemoglobin; D036361:Peptide Hormones; D014280:Triglycerides; C576683:ANGPTL8 protein, human