title: Impact of modifiable lifestyle factors on outcomes after breast cancer diagnosis: the Setouchi Breast Cancer Cohort Study.
abstract: The primary purpose of this large cohort study is to investigate the effects on breast cancer outcomes of modifiable lifestyle factors after breast cancer diagnosis. These factors include physical activity, smoking, alcohol consumption, obesity and weight gain after diagnosis, alternative medicine and dietary factors. Women diagnosed with Stage 0 to III breast cancer are eligible for participation to this study. Lifestyle, use of alternative medicine, psychosocial factors, reproductive factors and health-related quality of life will be assessed using a questionnaire at the time of breast cancer diagnosis (baseline), and 1, 2, 3 and 5 years after diagnosis. Clinical information and breast cancer outcomes will be obtained from a breast cancer database. The primary endpoint will be disease-free survival. Secondary endpoints are overall survival, health-related quality of life, breast cancer-related symptoms and adverse events. Patient recruitment commenced in February 2013. Enrollment of 2000 breast cancer patients is planned during the 5-year recruitment period. The concept of the study is described in this article.
authors.affiliation: Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama ntaira@md.okayama-u.ac.jp.
authors.forename: Naruto
authors.initials: N
authors.lastname: Taira
authors.affiliation: Department of Surgery, Okayama Medical Center, Okayama.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Akiyama
authors.affiliation: Department of Radiology, Okayama Saiseikai General Hospital, Okayama.
authors.forename: Setsuko
authors.initials: S
authors.lastname: Ishihara
authors.affiliation: Department of Surgery, Mizushima Kyodo Hospital, Okayama.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Ishibe
authors.affiliation: Department of Surgery, Kagawa Prefectural Central Hospital, Kagawa.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kawasaki
authors.affiliation: Department of Surgery, Yashima General Hospital, Kagawa.
authors.forename: Makoto
authors.initials: M
authors.lastname: Saito
authors.affiliation: Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama.
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Shien
authors.affiliation: Department of Breast and Thyroid Surgery, Kawasaki Medical School Hospital, Okayama.
authors.forename: Tsunehisa
authors.initials: T
authors.lastname: Nomura
authors.affiliation: Department of Breast Oncology, Shikoku Cancer Center, Ehime.
authors.forename: Fumikata
authors.initials: F
authors.lastname: Hara
authors.affiliation: Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama.
authors.forename: Taeko
authors.initials: T
authors.lastname: Mizoo
authors.affiliation: Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Mizota
authors.affiliation: Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yamamoto
authors.affiliation: Department of Breast Oncology, Shikoku Cancer Center, Ehime.
authors.forename: Shozo
authors.initials: S
authors.lastname: Ohsumi
authors.affiliation: Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Doihara
mesh_terms: D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications; D011788:Quality of Life; D040242:Risk Reduction Behavior; D012907:Smoking; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D015430:Weight Gain
keywords: alternative medicine; breast cancer; cohort study; lifestyle; prognosis; quality of life