title: Immuno-histochemical study of ovine cystic echinococcosis (Echinococcus granulosus) shows predominant T cell infiltration in established cysts.
abstract: Ovine hydatidosis (OH; Echinococcus granulosus) is endemic in several European countries surrounding the Mediterranean basin. There have been a limited number of studies aimed at evaluating the local immune response to established tissue cysts in the ovine host. In the present study, immunohistochemical analysis of lymphocyte populations surrounding established cysts showed a predominance of CD3+ T cells compared to CD79+ B cells. A percentage of infiltrating lymphocytes were also FoxP3+, suggesting that established ovine cysts may be protected from immune aggression through the suppressive action of T regulatory cells. The present study contributes to the understanding of local immune responses to ovine echinococcosis.
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Vismarra
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Mangia
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Passeri
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sardegna-CeNRE, Sassari, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Brundu
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sardegna-CeNRE, Sassari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Masala
authors.affiliation: Istituto Zooprofilattico Sperimentale della Sardegna-CeNRE, Sassari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Ledda
authors.affiliation: Fondazione IRCCS Policlinico San Mateo, Pavia, Italy; WHO Collaborating Centre for Clinical Management of Cystic Echinococcosis, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mariconti
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Brindani
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Kramer
authors.affiliation: Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Parma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bacci
mesh_terms: D000818:Animals; D004443:Echinococcosis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000469:parasitology* / Q000473:pathology; D013601:T-Lymphocytes / Q000502:physiology*
keywords: Echinococcus granulosus; Immunity; Immunohistochemistry; Sheep; T cells