title: Endoscopic and histologic characteristics of serrated lesions.
abstract: In recent years, a second pathway for colonic carcinogenesis, distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp, characterised by a serrated appearance of the crypts: hyperplastic polyps (HP), sessile serrated adenomas (SSA) or lesions, and traditional serrated adenomas. Each lesion has its own genetic, as well as macroscopic and microscopic morphological features. Because of their flat aspect, their detection is easier with chromoendoscopy (carmin indigo or narrow-band imaging). However, as we show in this review, the distinction between SSA and HP is quite difficult. It is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of dysplasia. These different types of lesion are described in detail in the present review in general population, in polyposis and in inflammatory bowel diseases patients. This review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis.
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Driffa
authors.initials: D
authors.lastname: Moussata
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Boschetti
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Chauvenet
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Stroeymeyt
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Nancey
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Berger
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lecomte
authors.affiliation: Driffa Moussata, Gilles Boschetti, Marion Chauvenet, Karine Stroeymeyt, Stéphane Nancey, Bernard Flourié, Department of Gastroenterology, Lyon Sud Hospital, 69310 Pierre Bénite, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Flourié
mesh_terms: D018256:Adenomatous Polyps / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D002863:Chromogenic Compounds; D003110:Colonic Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D003111:Colonic Polyps / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D003113:Colonoscopy / Q000379:methods; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia; D008853:Microscopy / Q000379:methods; D062048:Narrow Band Imaging; D011230:Precancerous Conditions / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D002863:Chromogenic Compounds
keywords: Endomicroscopy; Endoscopy; Histology; Hyperplastic polyp; Serrated polyposis; Sessile serrated adenoma; Traditional serrated adenoma