title: Formula to evaluate efficacy of vaccines and systemic substances against three-host ticks.
abstract: The control of ticks with vaccines is of global interest. Experimental vaccines incorporate new technologies as soon as they are available. Historically, the main vaccine studies have focused on the one-host cattle tick Rhipicephalus microplus, and efficacy evaluations have been standardised for this tick species. On the other hand, evaluations of vaccine candidates for three-host ticks are being done somewhat arbitrarily and thus comparisons within the current literature on the efficacy of vaccines, as well as other methods of control, are difficult. We herein provide a formula for the evaluation of efficacy of a vaccine designed against three-host ticks that incorporates the whole life cycle of the tick.
authors.affiliation: Programa de Pós-graduação em Doenças Infecciosas e Parasitarias, FAMED, UFMS, Campo Grande, MS, Brazil; Fundação Oswaldo Cruz, Fiocruz Rondônia, Porto Velho, RO, Brazil. Electronic address: andreaguirrevet@hotmail.com.
authors.forename: André de Abreu Rangel
authors.initials: Ade A
authors.lastname: Aguirre
authors.affiliation: Embrapa Gado de Corte, Avenida Rádio Maia n° 830, Zona Rural, CEP 79106-550, Campo Grande, MS, Brazil; Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brazil.
authors.forename: Marcos Valério
authors.initials: MV
authors.lastname: Garcia
authors.affiliation: Universidade Federal de Uberlândia - UFU, Uberlândia, MG, Brazil.
authors.forename: Matias Pablo Juan
authors.initials: MP
authors.lastname: Szabó
authors.affiliation: Embrapa Gado de Corte, Avenida Rádio Maia n° 830, Zona Rural, CEP 79106-550, Campo Grande, MS, Brazil.
authors.forename: Jacqueline Cavalcante
authors.initials: JC
authors.lastname: Barros
authors.affiliation: Embrapa Gado de Corte, Avenida Rádio Maia n° 830, Zona Rural, CEP 79106-550, Campo Grande, MS, Brazil.
authors.forename: Renato
authors.initials: R
authors.lastname: Andreotti
mesh_terms: D000818:Animals; D058507:Host Specificity; D008954:Models, Biological; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013987:Ticks / Q000145:classification* / Q000276:immunology / Q000502:physiology; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: Efficacy; Three-host; Tick; Vaccine