title: Calcinosis cutis presenting in the context of long-term therapy for chronic myeloid leukemia: a case report and review of the literature.
abstract: Calcinosis cutis is a poorly understood process in which calcium salts deposit in the skin and subcutaneous tissues. Due to its multifactorial pathogenesis, several subtypes and potential etiologies have been described. Presented here is a case of bilateral pretibial calcinosis cutis in a patient on long-term tyrosine kinase inhibitor therapy for chronic myeloid leukemia. The patient initially presented with a right tibial ulceration treated with multiple surgical debridements, antibiotics, and negative pressure wound therapy. The wound was ultimately closed with a split-thickness skin graft. Relevant literature is examined and several possible mechanisms are discussed.
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Section of Wound Healing and Tissue Repair, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL; email: ialtman@uic.edu.
authors.forename: Igor
authors.initials: I
authors.lastname: Altman
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Section of Wound Healing and Tissue Repair, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Ina H
authors.initials: IH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Section of Wound Healing and Tissue Repair, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Burns
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Section of Wound Healing and Tissue Repair, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: Damiano
authors.initials: D
authors.lastname: Rondelli
authors.affiliation: Department of Surgery, Division of Vascular Surgery, Section of Wound Healing and Tissue Repair, College of Medicine, University of Illinois Hospital and Health Sciences System, Chicago, IL.
authors.forename: William J
authors.initials: WJ
authors.lastname: Ennis
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002114:Calcinosis / Q000209:etiology*; D003646:Debridement / Q000379:methods*; D004318:Doxycycline / Q000008:administration & dosage; D006801:Humans; D007871:Leg Ulcer / Q000473:pathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054843:Negative-Pressure Wound Therapy / Q000379:methods; D012867:Skin / Q000473:pathology*; D016038:Skin Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000900:Anti-Bacterial Agents; D004318:Doxycycline