title: Dynamic Contrast-Enhanced MRI in the Study of Brain Tumors. Comparison Between the Extended Tofts-Kety Model and a Phenomenological Universalities (PUN) Algorithm.
abstract: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a well-established technique for studying blood-brain barrier (BBB) permeability that allows measurements to be made for a wide range of brain pathologies, including multiple sclerosis and brain tumors (BT). This latter application is particularly interesting, because high-grade gliomas are characterized by increased microvascular permeability and a loss of BBB function due to the structural abnormalities of the endothelial layer. In this study, we compared the extended Tofts-Kety (ETK) model and an extended derivate class from phenomenological universalities called EU1 in 30 adult patients with different BT grades. A total of 75 regions of interest were manually drawn on the MRI and subsequently analyzed using the ETK and EU1 algorithms. Significant linear correlations were found among the parameters obtained by these two algorithms. The means of R (2) obtained using ETK and EU1 models for high-grade tumors were 0.81 and 0.91, while those for low-grade tumors were 0.82 and 0.85, respectively; therefore, these two models are equivalent. In conclusion, we can confirm that the application of the EU1 model to the DCE-MRI experimental data might be a useful alternative to pharmacokinetic models in the study of BT, because the analytic results can be generated more quickly and easily than with the ETK model.
authors.affiliation: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Via De Toni 5, 16132, Genoa, Italy. maurizio.bergamino@gmail.com.|Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Via De Toni 5, 16132, Genoa, Italy. maurizio.bergamino@gmail.com.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bergamino
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Barletta
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
authors.forename: Lucio
authors.initials: L
authors.lastname: Castellan
authors.affiliation: Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Via De Toni 5, 16132, Genoa, Italy.|Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Via De Toni 5, 16132, Genoa, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Mancardi
authors.affiliation: Magnetic Resonance Research Centre on Nervous System Diseases, University of Genoa, Via De Toni 5, 16132, Genoa, Italy.|Department of Diagnostic and Interventional Neuroradiology, San Martino University Hospital, Largo Rosanna Benzi 10, 16132, Genoa, Italy.|Department of Health Sciences, University of Genoa, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Roccatagliata
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001932:Brain Neoplasms / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media
keywords: Blood–brain barrier; Brain tumors; DCE-MRI; EU1 algorithm; Extended Tofts-Kety model