title: [The influence of pre-transplantation dialysis modality on late C4d urinary excretion in kidney graft recipients].
abstract: BACKGROUND
  The C4d deposits as well as its urinary excretion are markers of the humoral acute kidney graft rejection. The pre-transplant dialysis modality influences on the post-transplant outcomes and it is possible that it may modify C4d urinary excretion.
  
  
  OBJECTIVE
  The aim of the study was the assessment of the pre-transplant dialysis modality on late C4d urinary excretion.
  
  
  METHODS
  The study comprised 185 patients who underwent kidney allograft transplantation (KTx). The urinary specimens taken from the morning urine portion was assessed by ELISA test for C4d excretion. To increase the objectivity of the assessment all measurements were divided by urinary creatinine excretion. The study population was grouped according the pre-transplant dialysis modality i.e. hemo- and peritoneal dialysis
  
  
  RESULTS
  In the study the C4d urinary excretion in patients treated with hemodialysis was higher than in peritoneal dialysis, irrespectively whether in direct measurements 221.1 ± 239.9 ng/ml vs 156.4 ± 188.7 ng/ml (p < 0.05) or when calculated per urinary creatinine 5.2 ± 7.1 ng/mgCr i 3.4 ± 7.9 ng/mgr (p < 0.05).
  
  
  CONCLUSIONS
  Pre-transplant dialysis modality influences late C4d urinary excretion.
authors.forename: Rafał
authors.initials: R
authors.lastname: Zwiech
mesh_terms: D000328:Adult; D064591:Allografts; D015415:Biomarkers / Q000652:urine; D015935:Complement C4b / Q000652:urine*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000652:urine*; D011044:Poland; D011300:Preoperative Care / Q000379:methods*; D006435:Renal Dialysis / Q000379:methods*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D015935:Complement C4b; C032261:complement C4d