title: Association between HLA-Ⅱgene polymorphism and Helicobacter pylori infection in Asian and European population: A meta-analysis.
abstract: BACKGROUND
  It is generally considered that HLA-Ⅱ genes contribute to the Helicobacter pylori (Hp) infection and disease development process.
  
  
  OBJECTIVE
  To perform a meta-analysis to explore the relationship between HLA-Ⅱgene polymorphism and host susceptibility to Hp infection.
  
  
  METHODS
  Relevant cohort studies, case-control studies and cross-sectional studies were identified by searching Cochrane Library, PubMed, EMBASE, Web of Science and CBM up to July 2014. The data were extracted and methodological quality of the studies were evaluated. RevMan5.0 software was used to perform statistical analysis.
  
  
  RESULTS
  In Asian population, HLA-DQB1*0303 acted as the protective gene in Hp infection (statistically significant pooled OR = 0.54) and the susceptible genes in Hp infection involved HLA-DQB1*0401, HLA-DQA1*0103 and HLA-DQA1*0301 (statistically significant pooled OR and 95%CI were 3.34(1.93,5.77), 1.64(1.16,2.33) and 2.03(1.20,3.44) respectively). No statistically significant difference between DQB1*0303, HLA-DQA1*0103 and DQA1*0301 and Hp infection in European population (P>0.05). And no statistically significant difference (P>0.05) in the overall effect of the association between the rest of HLA-Ⅱalleles and Hp infection.
  
  
  CONCLUSIONS
  In Asian population, the protective gene HLA-DQB1*0303 and the susceptible genes HLA-DQB1*0401, HLA-DQA1*0103 and HLA-DQA1*0301 in Hp infection were established by meta-analysis. And there was no HLA-Ⅱallele was found to associate with Hp infection among European population.
authors.affiliation: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China; School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Jingqiu
authors.initials: J
authors.lastname: Wang
authors.affiliation: General Hospital of Lanzhou Petrochemical Company, Lanzhou 730060, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Evidence-based Medicine Center of Lanzhou University, Lanzhou 730000, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.affiliation: School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Xingming
authors.initials: X
authors.lastname: Ma
authors.affiliation: School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Luo
authors.affiliation: School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Liang
authors.affiliation: School of Basic Medical Sciences of Lanzhou University, Lanzhou 730000, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China. Electronic address: yhh0817@126.com.
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001208:Asia / Q000453:epidemiology; D060467:Disease Resistance; D005060:Europe / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000453:epidemiology* / Q000235:genetics*; D016480:Helicobacter pylori / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D000949:Histocompatibility Antigens Class II
keywords: HLA-Ⅱalleles; Helicobacter pylori; Meta-analysis; Susceptibility