title: Gut microbiome development along the colorectal adenoma-carcinoma sequence.
abstract: Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] School of Bioscience and Biotechnology, South China University of Technology, Guangzhou 510006, China.
authors.forename: Suisha
authors.initials: S
authors.lastname: Liang
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Huijue
authors.identifier: 000000023592126X
authors.initials: H
authors.lastname: Jia
authors.affiliation: Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Paracelsusstrasse 37, 5110 Oberndorf, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Stadlmayr
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Longqing
authors.initials: L
authors.lastname: Tang
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Lan
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Dongya
authors.initials: D
authors.lastname: Zhang
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Huihua
authors.initials: H
authors.lastname: Xia
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Xu
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Zhuye
authors.initials: Z
authors.lastname: Jie
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Su
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Li
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] School of Bioscience and Biotechnology, South China University of Technology, Guangzhou 510006, China [3] BGI Hong Kong Research Institute, Hong Kong, China.
authors.forename: Junhua
authors.initials: J
authors.lastname: Li
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Paracelsusstrasse 37, 5110 Oberndorf, Austria.
authors.forename: Ursula
authors.initials: U
authors.lastname: Huber-Schönauer
authors.affiliation: Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Paracelsusstrasse 37, 5110 Oberndorf, Austria.
authors.forename: David
authors.initials: D
authors.lastname: Niederseer
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Xu
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors.forename: Jumana Yousuf
authors.initials: JY
authors.lastname: Al-Aama
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Huanming
authors.initials: H
authors.lastname: Yang
authors.affiliation: BGI-Shenzhen, Shenzhen 518083, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
authors.forename: Karsten
authors.initials: K
authors.lastname: Kristiansen
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Manimozhiyan
authors.identifier: 0000000208869101
authors.initials: M
authors.lastname: Arumugam
authors.affiliation: First Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
authors.forename: Herbert
authors.initials: H
authors.lastname: Tilg
authors.affiliation: Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Paracelsusstrasse 37, 5110 Oberndorf, Austria.
authors.forename: Christian
authors.initials: C
authors.lastname: Datz
authors.affiliation: 1] BGI-Shenzhen, Shenzhen 518083, China [2] Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark [3] Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Saudi Arabia [4] Macau University of Science and Technology, Avenida Wai long, Taipa, Macau 999078, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D039903:Actinobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D018256:Adenomatous Polyps / Q000209:etiology / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D041963:Bacteroidetes / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D004032:Diet; D018450:Disease Progression; D005243:Feces / Q000382:microbiology; D005260:Female; D000068536:Bacillota / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D000069196:Gastrointestinal Microbiome / Q000235:genetics*; D006801:Humans; D008297:Male; D054892:Metagenome; D008875:Middle Aged; D020560:Proteobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D000069466:Red Meat / Q000009:adverse effects; D012307:Risk Factors; D014675:Vegetables / Q000737:chemistry