title: [Expression of CysLTR-1 and CysLTR-2 in adenoid tissues from children with adenoid hypertrophy].
abstract: OBJECTIVE
  To examine the expression of cysteinyl leukotriene receptor-1 (CysLTR-1) and cysteinyl leukotriene receptor-2 (CysLTR-2) in the adenoid tissues from children with adenoid hypertrophy (AH) and to explore the role of leukotrienes in the pathogenesis of AH.
  
  
  METHODS
  Sixty children with AH who were treated by adenoidectomy and/or tonsillectomy were classified into two groups: simple AH and AH plus allergic rhinitis (n=30 each). Twenty children who underwent tonsillectomy due to recurrent purulent tonsillitis were selected as the control group. The expression of CysLTR-1 and CysLTR-2 in the excised tonsil and/or adenoid tissues was determined by immunofluorescence histochemical labeling and integrated optical density measurement.
  
  
  RESULTS
  The expression of CysLTR-1 and CysLTR-2 in the adenoid and tonsil tissues increased significantly in both the simple AH group and AH plus allergic rhinitis group compared with the control group (P<0.01). The expression of CysLTR-1 and CysLTR-2 in the AH plus allergic rhinitis group increased more significantly compared with the simple AH group (P<0.01).
  
  
  CONCLUSIONS
  CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.
authors.affiliation: Department of Pediatrics, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China. zmh1962cn@163.com.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Zhu
authors.forename: Min
authors.initials: M
authors.lastname: Liang
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Wen
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Zhai
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Yang
mesh_terms: D000234:Adenoids / Q000737:chemistry / Q000473:pathology*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D006984:Hypertrophy; D008297:Male; D018077:Receptors, Leukotriene / Q000032:analysis / Q000502:physiology*; D065631:Rhinitis, Allergic / Q000378:metabolism
chemical_list: D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2; C083169:leukotriene D4 receptor