title: Neurolymphomatosis: A report of 2 cases representing opposite ends of the clinical spectrum.
abstract: BACKGROUND
  Neurolymphomatosis (NL) is a rare disorder characterized by invasion of cranial or peripheral nerves, nerve roots, or plexi, usually by aggressive subtypes of non-Hodgkin lymphoma (NHL). The most common clinical presentation is that of a painful polyneuropathy or polyradiculopathy, followed by cranial neuropathy and, less frequently, by painless polyneuropathy.
  
  
  METHODS
  Clinical and pathologic findings are reported for 2 NL cases.
  
  
  RESULTS
  The following 2 patients with NL, with disparate clinical presentations, are presented: a patient with subacute onset, painful, multifocal, mixed axonal and demyelinating radiculoplexus neuropathy due to a large B-cell NHL, who required 2 targeted fascicular nerve biopsies to demonstrate NL; and a patient with a slowly progressive, length-dependent axonal polyneuropathy due to a low-grade B-cell lymphoproliferative disorder, as shown on a diagnostic sural nerve biopsy.
  
  
  CONCLUSIONS
  The cases described illustrate the wide clinical spectrum of NL.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Rochester, Minnesota, 55905, USA.
authors.forename: Rajat
authors.initials: R
authors.lastname: Lahoria
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Rochester, Minnesota, 55905, USA.
authors.forename: P James B
authors.initials: PJ
authors.lastname: Dyck
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Macon
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Rochester, Minnesota, 55905, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Crum
authors.affiliation: Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spinner
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Amrami
authors.affiliation: Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Zeldenrust
authors.affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, Rochester, Minnesota, 55905, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Tracy
mesh_terms: D018450:Disease Progression; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology / Q000503:physiopathology; D012584:Sciatic Nerve / Q000473:pathology
keywords: lymphoproliferative disorder; neurolymphomatosis; neuropathy; non-Hodgkin lymphoma; radiculoneuropathy