title: Roles of chromatin insulators in the formation of long-range contacts.
abstract: Chromatin insulators are factors involved in higher-order, genome-wide organization of chromatin, and play key roles in regulating transcriptional programs. In this review, we discuss recent studies on the diverse composition of insulator complexes, and on the mechanism by which they establish long-range DNA interactions. Particularly, we describe new biophysical methods that allow for the study of the composition of large molecular complexes, and for defining the factors potentially required to establish long-range DNA contacts.
authors.affiliation: a Centre de Biochimie Structurale ; CNRS UMR5048; INSERM U1054; Université de Montpellier ; Montpellier , France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Le Gall
authors.forename: Alessandro
authors.initials: A
authors.lastname: Valeri
authors.forename: Marcelo
authors.initials: M
authors.lastname: Nollmann
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D006801:Humans; D038101:Insulator Elements / Q000235:genetics*; D008954:Models, Biological; D013050:Spectrometry, Fluorescence
chemical_list: D002843:Chromatin
keywords: chromatin insulators; chromatin organization; fluorescence correlation spectroscopy; single-molecule; transcription regulation