title: Evaluation of deformable image registration methods for dose monitoring in head and neck radiotherapy.
abstract: In the context of head and neck cancer (HNC) adaptive radiation therapy (ART), the two purposes of the study were to compare the performance of multiple deformable image registration (DIR) methods and to quantify their impact for dose accumulation, in healthy structures. Fifteen HNC patients had a planning computed tomography (CT0) and weekly CTs during the 7 weeks of intensity-modulated radiation therapy (IMRT). Ten DIR approaches using different registration methods (demons or B-spline free form deformation (FFD)), preprocessing, and similarity metrics were tested. Two observers identified 14 landmarks (LM) on each CT-scan to compute LM registration error. The cumulated doses estimated by each method were compared. The two most effective DIR methods were the demons and the FFD, with both the mutual information (MI) metric and the filtered CTs. The corresponding LM registration accuracy (precision) was 2.44 mm (1.30 mm) and 2.54 mm (1.33 mm), respectively. The corresponding LM estimated cumulated dose accuracy (dose precision) was 0.85 Gy (0.93 Gy) and 0.88 Gy (0.95 Gy), respectively. The mean uncertainty (difference between maximal and minimal dose considering all the 10 methods) to estimate the cumulated mean dose to the parotid gland (PG) was 4.03 Gy (SD = 2.27 Gy, range: 1.06-8.91 Gy).
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France.
authors.forename: Bastien
authors.initials: B
authors.lastname: Rigaud
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Simon
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France ; Centre Eugene Marquis, Radiotherapy Department, 35000 Rennes, France.
authors.forename: Joël
authors.initials: J
authors.lastname: Castelli
authors.affiliation: Centre Eugene Marquis, Radiotherapy Department, 35000 Rennes, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Gobeli
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France.
authors.forename: Juan-David
authors.initials: JD
authors.lastname: Ospina Arango
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cazoulat
authors.affiliation: Centre Eugene Marquis, Radiotherapy Department, 35000 Rennes, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Henry
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Haigron
authors.affiliation: Université de Rennes 1, LTSI, Campus de Beaulieu, 35000 Rennes, France ; INSERM, U1099, Campus de Beaulieu, 35000 Rennes, France ; Centre Eugene Marquis, Radiotherapy Department, 35000 Rennes, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: De Crevoisier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods