title: The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis.
abstract: OBJECTIVE
  There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN.
  
  
  METHODS
  We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013.
  
  
  METHODS
  We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C).
  
  
  METHODS
  CRN cases (n 21 809) were identified.
  
  
  RESULTS
  Overall, people with high levels of serum TAG (risk ratio (RR)=1.08; 95% CI 1.05, 1.12, P<0.00001) and LDL-C (RR=1.07; 95% CI 1.00, 1.14, P=0.04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR=1.04; 95% CI 1.01, 1.09, P=0.02), TAG (RR=1.06; 95% CI 1.03, 1.10, P=0.0009) and LDL-C (RR=1.11; 95% CI 1.04, 1.19, P=0.003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed.
  
  
  CONCLUSIONS
  Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN.
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Tian
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Keming
authors.initials: K
authors.lastname: Wang
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Jirong
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1Department of Oncology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Yingrui
authors.initials: Y
authors.lastname: Fan
authors.affiliation: 2Emergency Center,Affiliated Hospital of Xuzhou Medical College,Xuzhou,People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ye
authors.affiliation: 3Institute of Digestive Endoscopy and Medical Center for Digestive Diseases,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,People's Republic of China.
authors.forename: Guozhong
authors.initials: G
authors.lastname: Ji
authors.affiliation: 4Department of General Surgery,Jinling Hospital,Medical School of Nanjing University,No. 305 East Zhongshan Road,Nanjing 210002,People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
mesh_terms: D000236:Adenoma / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015179:Colorectal Neoplasms / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D050171:Dyslipidemias / Q000503:physiopathology*; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology; D015228:Hypertriglyceridemia / Q000503:physiopathology; D015994:Incidence; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Colorectal adenoma; Colorectal cancer; Meta-analysis; Serum lipids; TAG