title: Primary juxtaovarian yolk sac tumor concurrent with an ipsilateral ovarian mature teratoma in an adult woman: a rare association.
abstract: OBJECTIVE
  Yolk sac tumor (YST) is a rare neoplasm that primarily occurs in the ovary in children and young women. Previously, it has been reported that the teratomatous components can be recognized in part of YSTs or appear in the contralateral ovary. Here, we report a rare case of an adult woman with a juxtaovarian YST concurrent with an ipsilateral ovarian mature teratoma.
  
  
  METHODS
  A 47-year-old woman found a pelvic mass for nine days and subsequently underwent debulking operation. The specimens were evaluated for detailed characterizations through gross examination, microscopy and immunohistochemistry. A literature review was performed and the pathogenesis was briefly discussed about the generation of an extraovarian YST concurrent with a teratoma.
  
  
  RESULTS
  The right juxtaovarian tumor showed typical histological patterns of YST. Immunostaining demonstrated the YST nature of Gly-3 and AFP positive tumor cells. The ipsilateral ovarian tumor was a common mature cystic teratoma with chronic fibrotic changes. According to the differences of the origin and the differentiation of the two germ cell tumors, we suspect that the occurrence of the teratoma is earlier than the YST.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of an adult woman with a juxtaovarian YST concurrent with an ipsilateral ovarian mature teratoma.
authors.affiliation: Department of Pathology, Beilun People's Hospital Ningbo 315800, Zhejiang Province, China.
authors.forename: Haifen
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Pathology, Beilun People's Hospital Ningbo 315800, Zhejiang Province, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Pathology, Beilun People's Hospital Ningbo 315800, Zhejiang Province, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Pathology, Beilun People's Hospital Ningbo 315800, Zhejiang Province, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D018240:Endodermal Sinus Tumor / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*
keywords: Yolk sac tumor; adult; concurrent; extraovarian; ipsilateral; ovarian mature teratoma