title: Practical molecular pathology and histopathology of embryonal tumors.
abstract: There have been significant improvements in understanding of embryonal tumors of the central nervous system (CNS) in recent years. These advances are most likely to influence the diagnostic algorithms and methodology currently proposed by the World Health Organization (WHO) classification scheme. Molecular evidence suggests that the tumors presumed to be specific entities within the CNS/primitive neuroectodermal tumors spectrum are likely to be reclassified. All these developments compel reassessing current status and expectations from the upcoming WHO classification efforts. This review provides a synopsis of current developments and a practical algorithm for the work-up of these tumors in practice.
authors.affiliation: Neuropathology Division, Department of Pathology, UCSF School of Medicine, UCSF Medical Center, Room M551, 505 Parnassus Avenue, San Francisco, CA, USA. Electronic address: joanna.phillips@ucsf.edu.
authors.forename: Joanna
authors.initials: J
authors.lastname: Phillips
authors.affiliation: Neuropathology Division, Department of Pathology, UCSF School of Medicine, UCSF Medical Center, Room M551, 505 Parnassus Avenue, San Francisco, CA, USA.
authors.forename: Tarik
authors.initials: T
authors.lastname: Tihan
authors.affiliation: Neuropathology Division, Department of Pathology, UCSF School of Medicine, UCSF Medical Center, Room M551, 505 Parnassus Avenue, San Francisco, CA, USA; University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Fuller
mesh_terms: D016543:Central Nervous System Neoplasms / Q000145:classification / Q000473:pathology*; D006801:Humans; D008527:Medulloblastoma / Q000145:classification / Q000473:pathology; D009373:Neoplasms, Germ Cell and Embryonal / Q000145:classification / Q000473:pathology*; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000145:classification / Q000473:pathology; D018570:Risk Assessment; D013724:Teratoma / Q000145:classification / Q000473:pathology
keywords: Embryonal tumors; Histopathology; Molecular pathology; WHO classification