title: Brain and behavioral evidence for altered social learning mechanisms among women with assault-related posttraumatic stress disorder.
abstract: Current neurocircuitry models of PTSD focus on the neural mechanisms that mediate hypervigilance for threat and fear inhibition/extinction learning. Less focus has been directed towards explaining social deficits and heightened risk of revictimization observed among individuals with PTSD related to physical or sexual assault. The purpose of the present study was to foster more comprehensive theoretical models of PTSD by testing the hypothesis that assault-related PTSD is associated with behavioral impairments in a social trust and reciprocity task and corresponding alterations in the neural encoding of social learning mechanisms. Adult women with assault-related PTSD (n = 25) and control women (n = 15) completed a multi-trial trust game outside of the MRI scanner. A subset of these participants (15 with PTSD and 14 controls) also completed a social and non-social reinforcement learning task during 3T fMRI. Brain regions that encoded the computationally modeled parameters of value expectation, prediction error, and volatility (i.e., uncertainty) were defined and compared between groups. The PTSD group demonstrated slower learning rates during the trust game and social prediction errors had a lesser impact on subsequent investment decisions. PTSD was also associated with greater encoding of negative expected social outcomes in perigenual anterior cingulate cortex and bilateral middle frontal gyri, and greater encoding of social prediction errors in the left temporoparietal junction. These data suggest mechanisms of PTSD-related deficits in social functioning and heightened risk for re-victimization in assault victims; however, comorbidity in the PTSD group and the lack of a trauma-exposed control group temper conclusions about PTSD specifically.
authors.affiliation: Brain Imaging Research Center, Psychiatric Research Institute, University of Arkansas for Medical Sciences, USA. Electronic address: jcisler@uams.edu.
authors.forename: Josh M
authors.initials: JM
authors.lastname: Cisler
authors.affiliation: Computer Science, Engineering and Information Technology, University of Arkansas at Little Rock, USA.
authors.forename: Keith
authors.initials: K
authors.lastname: Bush
authors.affiliation: Brain Imaging Research Center, Psychiatric Research Institute, University of Arkansas for Medical Sciences, USA.
authors.forename: J
authors.initials: J
authors.lastname: Scott Steele
authors.affiliation: Department of Psychology, New York University, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Lenow
authors.affiliation: Brain Imaging Research Center, Psychiatric Research Institute, University of Arkansas for Medical Sciences, USA.
authors.forename: Sonet
authors.initials: S
authors.lastname: Smitherman
authors.affiliation: Brain Imaging Research Center, Psychiatric Research Institute, University of Arkansas for Medical Sciences, USA.
authors.forename: Clinton D
authors.initials: CD
authors.lastname: Kilts
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D001931:Brain Mapping; D019548:Crime Victims / Q000523:psychology*; D005260:Female; D005717:Games, Experimental; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012054:Reinforcement, Psychology; D012742:Sex Offenses / Q000523:psychology*; D000067570:Social Learning / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000473:pathology / Q000523:psychology / Q000534:rehabilitation; D035502:Trust / Q000523:psychology; D055815:Young Adult
chemical_list: D010100:Oxygen
keywords: Assault; PTSD; Reinforcement learning; Social deficits; Trust; fMRI