title: BRAF(V600E) mutations are found in Richter syndrome and may allow targeted therapy in a subset of patients.
authors.affiliation: Department of Haematology, University College London Cancer Institute, London, UK.
authors.forename: Rob S
authors.initials: RS
authors.lastname: Sellar
authors.affiliation: Institute of Pathology, University of Tubingen, Tubingen, Germany.
authors.forename: Falko
authors.initials: F
authors.lastname: Fend
authors.affiliation: Department of Cellular Pathology, University College London, London, UK.
authors.forename: Ayse U
authors.initials: AU
authors.lastname: Akarca
authors.affiliation: Haematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Agostinelli
authors.affiliation: Department of Cellular Pathology, University College London, London, UK.
authors.forename: Vishvesh
authors.initials: V
authors.lastname: Shende
authors.affiliation: Institute of Pathology, University of Tubingen, Tubingen, Germany.
authors.forename: Leticia
authors.initials: L
authors.lastname: Quintanilla-Martínez
authors.affiliation: Berlin Reference and Consultation Centre for Lymphoma and Haematopathology, Pathodiagnostik, Berlin, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Stein
authors.affiliation: Haematopathology Unit, Department of Experimental Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Pileri
authors.affiliation: Department of Haematology, University College London Cancer Institute, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Linch
authors.affiliation: Department of Cellular Pathology, University College London, London, UK. t.marafioti@ucl.ac.uk.
authors.forename: Teresa
authors.initials: T
authors.lastname: Marafioti
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAFV600E inhibitors; BRAFV600E mutations; chronic lymphocytic leukaemia; richter transformation; targeted therapy