title: Association of Deficiency of Coagulation Factors (Prs, Prc, ATIII) and FVL Positivity with Preeclampsia and/or Eclampsia in Pregnant Women.
abstract: BACKGROUND
  Thrombophilia is a pathological state of increased blood coagulability. It causes problems during pregnancy including preeclampsia, stillbirth, repeated abortions, and detached pair. Out of the most prevalent factors causing inherited thrombophilia, protein S (Prs), protein C (Prc), and antithrombin III (ATIII) deficiency, and Factor V Leiden (FVL) mutation could be mentioned. This study aimed to investigate association of these parameters with preeclampsia.
  
  
  METHODS
  In this case-control study, 142 pregnant women with preeclampsia referred to Obstetric Clinic of Hajar Hospital, southwest of Iran, were assigned to the case group after clinical laboratory tests and according to specialist point of view and 142 pregnant women with normal blood pressure were assigned to the control group. After obtaining consent and completing relevant questionnaire, a 4-cc blood sample was taken from the patients. Coagulation factors and FVL rate were measured and after 6 months patients were followed- up. Data analysis was done by SPSS software using t-test.
  
  
  RESULTS
  In view of deficiency of Prs, Prc, and ATIII, no statistically significant association was observed between case and control groups (P>0.05). Statistical t-test indicated that the rate of FVL deficiency in pregnant patients with preeclampsia was significantly different from that in the control group (p=0.03). In addition, the body mass index of case group was significantly higher than that of control group prior to pregnancy (P=0.001). In case group, preeclampsia history contributed to development of current preeclampsia in contrast to control group (p<0.001). The patients of case group were followed up after 6 months in view of blood pressure and all had a normal mean blood pressure at the completion of the study.
  
  
  CONCLUSIONS
  Measurement of FVL deficiency could help to decrease the unpleasant complications of vascular disorders during pregnancy. But, screening test for pre-eclampsia does not seem necessary to determine the deficiency of coagulation factors, Prs, Prc, and ATIII.
authors.affiliation: Department of Gynecology and Obstetrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Maryam Al-E-Rasul
authors.initials: MA
authors.lastname: Dehkordi
authors.affiliation: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Soleimani
authors.affiliation: Division of Hematology, Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Haji-Gholami
authors.affiliation: Deputy of Research and Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Abdolrahim Kazemi
authors.initials: AK
authors.lastname: Vardanjani
authors.affiliation: General Practitioner, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Saeid Al-E-Rasul
authors.initials: SA
authors.lastname: Dehkordi
keywords: Coagulation Factors; Eclampsia; Factor V Leiden; Pre-eclampsia; Thrombophilia