title: Very late relapse of bilateral retinoblastoma.
abstract: Retinoblastoma usually recurs within the first few years after treatment completion. We report a rare case of very late relapse in a 6-month-old girl who was diagnosed with bilateral retinoblastoma. The patient achieved first remission after treatment with neoadjuvant chemotherapy, enucleation of the right eye, local laser therapy of the left eye, and adjuvant chemotherapy. Extraocular relapse with multiple metastases occurred 13 years and 8 months after treatment. The patient is currently in second complete remission after receiving high-dose chemotherapy and autologous stem cell transplantation. In conclusion, long-term follow-up is needed for early detection of recurrent retinoblastoma.
authors.affiliation: Departments of *Pediatrics §Ophthalmology ∥Pathology ¶Radiology, Seoul National University College of Medicine †Cancer Research Institute, Seoul National University ‡Department of Pediatrics, Seoul National University Boramae Medical Center, Seoul, Korea.
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Choi
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Ju
authors.forename: Che Ry
authors.initials: CR
authors.lastname: Hong
authors.forename: Hyery
authors.initials: H
authors.lastname: Kim
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Yu
authors.forename: Sung-Hye
authors.initials: SH
authors.lastname: Park
authors.forename: Jung-Eun
authors.initials: JE
authors.lastname: Cheon
authors.forename: Kyung Duk
authors.initials: KD
authors.lastname: Park
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007223:Infant; D009364:Neoplasm Recurrence, Local; D019572:Retinal Neoplasms / Q000628:therapy*; D012175:Retinoblastoma / Q000628:therapy*; D033581:Stem Cell Transplantation; D013997:Time Factors