title: Topiramate has protective effect on renal injury.
abstract: BACKGROUND
  Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage.
  
  
  METHODS
  A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. After laparotomy, cross ligation of infrarenal abdominal aorta was applied for two hours in I/R groups which was followed by two hours of reperfusion. TPM (100 mg/kg/day) was orally administrated to animals in the I/R+TPM group for seven consecutive days before I/R.
  
  
  RESULTS
  The I/R group's TNF-α and interleukin-1 beta (IL-1β) levels were significantly higher (1184.2 ± 129.1 pg/mg protein; 413.1 ± 28.8 pg/mg protein, respectively) than those of the control (907.8 ± 113.0 pg/mg protein, p = 0.002; 374.7 ± 23.7 pg/mg protein, p = 0.010, respectively) and I/R+TPM groups (999.5 ± 115.2 pg/mg protein, p < 0.001; 377.9 ± 30.9 pg/mg protein, p = 0.007, respectively).
  
  
  CONCLUSIONS
  TPM may partially prevent renal damage in rats. The opening of new horizons of this kind of knowledge will help understand the complex challenge in the prevention of renal I/R damage (Tab. 1, Fig. 3, Ref. 42).
authors.forename: M C
authors.initials: MC
authors.lastname: Cure
authors.forename: E
authors.initials: E
authors.lastname: Cure
authors.forename: L
authors.initials: L
authors.lastname: Tumkaya
authors.forename: Y
authors.initials: Y
authors.lastname: Kalkan
authors.forename: I
authors.initials: I
authors.lastname: Aydin
authors.forename: A
authors.initials: A
authors.lastname: Kirbas
authors.forename: H
authors.initials: H
authors.lastname: Efe
authors.forename: I
authors.initials: I
authors.lastname: Sehitoglu
authors.forename: S
authors.initials: S
authors.lastname: Yuce
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D005632:Fructose / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000077236:Topiramate
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose
keywords: carbonic anhydrase II.; ischemia reperfusion; kidney; topiramate