title: Pathogenic CD8+ T cells in experimental cerebral malaria.
abstract: Cerebral malaria (CM) is one the major complications occurring during malaria infection. The mechanisms leading to this syndrome are still not completely understood. Although it is clear that parasite sequestration is the key initiation factor, the downstream pathological processes are still highly debated. The experimental cerebral malaria (ECM) model, in which susceptible mice are infected with Plasmodium berghei ANKA, has led to the identification of CD8(+) T cells as the major mediator of ECM death. In this review, we discuss the recent advances and future developments in the understanding of the role of CD8(+) T cells in CM.
authors.affiliation: Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
authors.forename: Shanshan Wu
authors.initials: SW
authors.lastname: Howland
authors.forename: Carla
authors.initials: C
authors.lastname: Claser
authors.forename: Chek Meng
authors.initials: CM
authors.lastname: Poh
authors.forename: Sin Yee
authors.initials: SY
authors.lastname: Gun
authors.forename: Laurent
authors.initials: L
authors.lastname: Rénia
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002465:Cell Movement; D003602:Cytotoxicity, Immunologic; D004195:Disease Models, Animal; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology; D005109:Extracellular Matrix / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D016779:Malaria, Cerebral / Q000276:immunology* / Q000469:parasitology; D010641:Phenotype; D010961:Plasmodium / Q000276:immunology
chemical_list: D018984:Epitopes, T-Lymphocyte