title: Photoacoustic imaging of acupuncture effect in small animals.
abstract: Acupuncture has been a powerful clinical tool for treating chronic diseases. However, there is currently no appropriate method to clarify the therapeutic effect of acupuncture. Here, we use photoacoustic tomography (PAT) to study the effect of acupuncture on mouse brain blood vessels. Ten healthy mice were stimulated with acupuncture needles on two acupoints. PAT images were obtained before and after acupuncture. We report that stimulation of certain acupoints resulted in changes in hemodynamics/blood flow at these points. The results demonstrate that PAT can non-invasively detect blood flow changes in mouse brain under acupuncture. This pilot study shows the potential of PAT as a visualization tool for illuminating the mechanism of acupuncture and promoting its clinical applications.
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China ; These authors contributed equally to this work.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.affiliation: Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China ; These authors contributed equally to this work.
authors.forename: Xueliang
authors.initials: X
authors.lastname: Xu
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Bingzhang
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Rong
authors.affiliation: School of Physical Electronics, University of Electronic Science and Technology of China, Chengdu, Sichuan, China ; Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.
authors.forename: Huabei
authors.initials: H
authors.lastname: Jiang
keywords: (110.5120) Photoacoustic imaging; (170.3880) Medical and biological imaging