title: Oncotype DX(®) colon cancer assay for prediction of recurrence risk in patients with stage II and III colon cancer: A review of the evidence.
abstract: Advances in molecular biology have enabled identification of tumor biomarkers that allow for individualized risk assessment for patients with cancer. Molecular predictors of clinical outcome can help inform discussion regarding the role of adjuvant chemotherapy in patients with resected colon cancer, such as those with stage II colon cancer in which the benefit of adjuvant therapy is controversial or those with stage III colon cancer who may have a lower risk of recurrence and less absolute benefit from oxaliplatin therapy. This article summarizes the data surrounding the development, validation, and clinical and economic utility of the Oncotype DX(®) colon cancer assay, a multigene expression assay validated to independently predict recurrence risk in patients with stage II and III colon cancer beyond traditional factors.
authors.affiliation: Department of Surgical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Y Nancy
authors.initials: YN
authors.lastname: You
authors.affiliation: Mt. Pleasant, SC, USA.
authors.forename: Rudolph B
authors.initials: RB
authors.lastname: Rustin
authors.affiliation: Hofstra North Shore-LIJ Medical School, Department of Surgery, Division of Surgical Oncology, Great Neck, NY, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Sullivan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D000077150:Oxaliplatin; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: 12-Gene assay; Adjuvant chemotherapy; Colon cancer; Colon cancer recurrence risk; Colon cancer treatment; Genomic assay; Multigene assay; Oncotype DX; Oxaliplatin