title: Aggregates of silicon quantum dots as a drug carrier: selective intracellular drug release based on pH-responsive aggregation/dispersion.
abstract: Using amine-modified silicon quantum dots (Si-QDs) with visible photoluminescence as a building block, drug-loaded Si-QD aggregates were assembled. The aggregates were designed to break down in response to the endosomal pH decrease, which enabled the selective intracellular release of the loaded drugs.
authors.affiliation: Department of Chemical System Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. s-ohta@chemsys.t.u-tokyo.ac.jp.
authors.forename: Seiichi
authors.initials: S
authors.lastname: Ohta
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamura
authors.forename: Susumu
authors.initials: S
authors.lastname: Inasawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamaguchi
mesh_terms: D000588:Amines / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D011992:Endosomes / Q000737:chemistry* / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D045663:Quantum Dots / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*
chemical_list: D000588:Amines; D004337:Drug Carriers; D012825:Silicon