title: Cervical cancer: Biomarkers for diagnosis and treatment.
abstract: Cervical cancer is a major gynecological cancer which involves uncontrolled cell division and tissue invasiveness of the female uterine cervix. With the availability of new technologies researchers have increased their efforts to develop novel biomarkers for early diagnosis, and evaluation and monitoring of therapeutic treatments. This approach will help in the development of early diagnosis and in increasing treatment efficacy with decreased recurrence. The present review explains the currently available biomarkers for cervical cancer diagnosis and prognosis. Apart from the currently available biomarkers the review also explains strategies for the development of biomarkers based on cellular and molecular approaches such as DNA, protein and other metabolic markers with suitable clinical examples. The investigations of specific proteins, enzymes and metabolites will establish more useful biomarkers for accurate detection and management of gynecological cancers especially cervical cancer.
authors.affiliation: Department of Biotechnology, Dravidian University, Kuppam, 517426 AP, India.
authors.forename: Subramanyam
authors.initials: S
authors.lastname: Dasari
authors.affiliation: Department of Zoology, Sri Venkateswara University, Tirupati, 517502 AP, India.
authors.forename: Rajendra
authors.initials: R
authors.lastname: Wudayagiri
authors.affiliation: Department of Biotechnology, Dravidian University, Kuppam, 517426 AP, India. Electronic address: lokanath.valluru@gmail.com.
authors.forename: Lokanatha
authors.initials: L
authors.lastname: Valluru
mesh_terms: D054392:Adipokines / Q000235:genetics; D000951:Antigens, Neoplasm / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D018394:CA-125 Antigen / Q000235:genetics; D002272:Carcinoembryonic Antigen / Q000235:genetics; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology; D000071451:Chitinase-3-Like Protein 1; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics; D053539:Keratin-19 / Q000235:genetics; D037102:Lectins / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D027383:Papillomaviridae / Q000737:chemistry; D015843:Serpins / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D054392:Adipokines; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; C497483:CD44 protein, human; C084533:CHI3L1 protein, human; D002272:Carcinoembryonic Antigen; D000071451:Chitinase-3-Like Protein 1; D004279:DNA, Viral; D018960:Hyaluronan Receptors; D053539:Keratin-19; D037102:Lectins; D015843:Serpins; C102012:antigen CYFRA21.1; C051072:squamous cell carcinoma-related antigen; D020780:Matrix Metalloproteinase 9
keywords: Biomarkers; Cancer antigen; Cervical cancer; Diagnosis; Magnetic resonance imaging; Prognosis