title: [Comparison of droperidol and ondansetron prophylactic effect on subarachnoid morphine-induced pruritus].
abstract: OBJECTIVE
  The prophylactic effect of ondansetron on subarachnoid morphine-induced pruritus is controversial, while evidence suggests that droperidol prevents pruritus. The aim of this study is to compare the effects of droperidol and ondansetron on subarachnoid morphine-induced pruritus.
  
  
  METHODS
  180 ASA I or II patients scheduled to undergo cesarean sections under subarachnoid anesthesia combined with morphine 0.2mg were randomized to receive, after the child's birth, metoclopramide 10mg (Group I - control), droperidol 2.5mg (Group II) or ondansetron 8mg (Group III). Postoperatively, the patients were assessed for pruritus (absent, mild, moderate or severe) or other side effects by blinded investigators. Patients were also blinded to their group allocation. The tendency to present more severe forms of pruritus was compared between groups. NNT was also determined.
  
  
  RESULTS
  Patients assigned to receive droperidol [Proportional odds ratio: 0.45 (95% confidence interval 0.23-0.88)] reported less pruritus than those who received metoclopramide. Ondansetron effect was similar to metoclopramide [Proportional odds ratio: 0.95 (95% confidence interval 0.49-1.83)]. The NNT for droperidol and ondansetron was 4.0 and 14.7, respectively.
  
  
  CONCLUSIONS
  Ondansetron does not inhibit subarachnoid morphine-induced pruritus.
authors.affiliation: Anestesiologia, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil. Electronic address: marciolealhorta@gmail.com.
authors.forename: Fabio Ferreira da Cunha
authors.initials: FF
authors.lastname: Brião
authors.affiliation: Anestesiologia, Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: Marcio Leal
authors.initials: ML
authors.lastname: Horta
authors.affiliation: Epidemiologia, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brasil.
authors.forename: Bernardo Lessa
authors.initials: BL
authors.lastname: Horta
authors.affiliation: Universidade Estadual Paulista, Faculdade de Medicina de Botucatu (UNESP), Pelotas, RS, Brasil.
authors.forename: Guilherme Antônio Moreira de
authors.initials: GA
authors.lastname: Barros
authors.affiliation: Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Behrensdorf
authors.affiliation: Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Severo
authors.affiliation: Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: Mariana Antunes
authors.initials: MA
authors.lastname: Nunes
authors.affiliation: Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: Roberta
authors.initials: R
authors.lastname: Boabaid
authors.affiliation: Universidade Católica de Pelotas (UCPel), Pelotas, RS, Brasil.
authors.forename: André
authors.initials: A
authors.lastname: Real
keywords: Droperidol; Injeção subaracnoidea; Morfina; Morphine; Ondansetron; Prurido; Pruritus; Subarachnoid injection