title: Clinical Development and Regulatory Approval of Acute Heart Failure Drugs in Japan : Editorial to: "Rationale and Design of Double-Blind, Randomized, Placebo-Controlled Multicenter Trial on Efficacy of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure (EARLIER)" by M. Asakura et al.
authors.affiliation: Office of New Drug II, Pharmaceuticals and Medical Devices Agency, Shin-kasumigaseki Building, 3-3-2, Kasumigaseki, Chiyoda-ku, Tokyo, 100-0013, Japan, shinagawa-kaori@pmda.go.jp.
authors.forename: Kaori
authors.initials: K
authors.lastname: Shinagawa
mesh_terms: D002985:Clinical Protocols; D061345:Early Medical Intervention / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use*; D013148:Spironolactone / Q000031:analogs & derivatives*
chemical_list: D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone