title: Investigating Protein Structure and Evolution with SCOP2.
abstract: SCOP2 is a successor to the Structural Classification of Proteins (SCOP) database that organizes proteins of known structure according to their structural and evolutionary relationships. It was designed to provide a more advanced framework for the classification of proteins. The SCOP2 classification is described in terms of a directed acyclic graph in which each node defines a relationship of particular type that is represented by a region of protein structure and sequence. The SCOP2 data are accessible via SCOP2-Browser and SCOP2-Graph. This protocol unit describes different ways to explore and investigate the SCOP2 evolutionary and structural groupings.
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
authors.forename: Antonina
authors.initials: A
authors.lastname: Andreeva
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
authors.forename: Dave
authors.initials: D
authors.lastname: Howorth
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chothia
authors.affiliation: European Bioinformatics Institute, Hinxton, Cambridge, United Kingdom.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kulesha
authors.affiliation: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, United Kingdom.
authors.forename: Alexey G
authors.initials: AG
authors.lastname: Murzin
mesh_terms: D000595:Amino Acid Sequence; D030562:Databases, Protein; D019143:Evolution, Molecular; D020407:Internet; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins
keywords: protein evolution; protein structure; sequence-structure relationship