title: Fabricated Elastin.
abstract: The mechanical stability, elasticity, inherent bioactivity, and self-assembly properties of elastin make it a highly attractive candidate for the fabrication of versatile biomaterials. The ability to engineer specific peptide sequences derived from elastin allows the precise control of these physicochemical and organizational characteristics, and further broadens the diversity of elastin-based applications. Elastin and elastin-like peptides can also be modified or blended with other natural or synthetic moieties, including peptides, proteins, polysaccharides, and polymers, to augment existing capabilities or confer additional architectural and biofunctional features to compositionally pure materials. Elastin and elastin-based composites have been subjected to diverse fabrication processes, including heating, electrospinning, wet spinning, solvent casting, freeze-drying, and cross-linking, for the manufacture of particles, fibers, gels, tubes, sheets and films. The resulting materials can be tailored to possess specific strength, elasticity, morphology, topography, porosity, wettability, surface charge, and bioactivity. This extraordinary tunability of elastin-based constructs enables their use in a range of biomedical and tissue engineering applications such as targeted drug delivery, cell encapsulation, vascular repair, nerve regeneration, wound healing, and dermal, cartilage, bone, and dental replacement.
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: Giselle C
authors.initials: GC
authors.lastname: Yeo
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: Behnaz
authors.initials: B
authors.lastname: Aghaei-Ghareh-Bolagh
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: Edwin P
authors.initials: EP
authors.lastname: Brackenreg
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: Matti A
authors.initials: MA
authors.lastname: Hiob
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: Pearl
authors.initials: P
authors.lastname: Lee
authors.affiliation: Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.|School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.|Bosch Institute, The University of Sydney, NSW 2006, Australia.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Weiss
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems; D004549:Elastin / Q000737:chemistry*; D006801:Humans; D010455:Peptides / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D010455:Peptides; D004549:Elastin
keywords: biomaterials; elastin; elastin-like peptides; fabrication; tissue engineering; tropoelastin