title: Inflammasomes in aspergillosis--it takes two to tango.
abstract: Intracellular inflammasome complexes regulate critical cytokine responses to infections. In this issue of Cell Host & Microbe,Karki et al. (2015) show that protection against the fungus Aspergillus requires the combined efforts of the NLRP3 and AIM2 inflammasomes and involves both caspase-1 and caspase-8.
authors.affiliation: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tomalka
authors.affiliation: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Geriatric Research Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA; Center for Global Health and Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: amy.hise@case.edu.
authors.forename: Amy G
authors.initials: AG
authors.lastname: Hise
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000276:immunology*; D002352:Carrier Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D058847:Inflammasomes / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D058847:Inflammasomes