title: Hypervalent iodine mediated alkene difunctionalization of vinylphenols: diastereoselective synthesis of substituted indoles and indolizines.
abstract: A hypervalent iodine mediated alkene difunctionalization reaction of vinylphenols has been developed. The chemistry is applicable to a wide range of substitutions on both the alkene and nucleophile substrates, enabling the rapid synthesis of 3-substituted indoles and 2-substituted indolizines in good yields and high diastereoselectivities under metal-free conditions.
authors.affiliation: Department of Chemistry, Zhejiang University, 148 Tianmushan Road, Hangzhou 310028, China. hfding@zju.edu.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Hang
authors.initials: H
authors.lastname: Wang
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zheng
authors.forename: Lei
authors.initials: L
authors.lastname: Yu
authors.forename: Hanfeng
authors.initials: H
authors.lastname: Ding
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D007211:Indoles; D007212:Indolizines; D010636:Phenols; D007455:Iodine