title: Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53.
abstract: Small ruminant lentivirus (SRLV) infections of sheep are influenced by genetics on both the host and pathogen sides. Genetic variation in the ovine transmembrane 154 (TMEM154) gene associates with infection susceptibility, and distinct SRLV genetic subgroups infect sheep in association with their TMEM154 diplotypes. In this study, a novel SRLV subgroup was identified that naturally infected sheep with various TMEM154 diplotypes, including those homozygous for a rare frameshift mutation (A4 delta53), which is predicted to abolish TMEM154 protein function. Thus, these SRLVs may infect sheep that lack functional TMEM154, and may not be restricted by TMEM154 diplotypes in establishing infections.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Clawson
authors.forename: Reid
authors.initials: R
authors.lastname: Redden
authors.forename: Gennie
authors.initials: G
authors.lastname: Schuller
authors.forename: Michael P
authors.initials: MP
authors.lastname: Heaton
authors.forename: Aspen
authors.initials: A
authors.lastname: Workman
authors.forename: Carol G
authors.initials: CG
authors.lastname: Chitko-McKown
authors.forename: Timothy P L
authors.initials: TP
authors.lastname: Smith
authors.forename: Kreg A
authors.initials: KA
authors.lastname: Leymaster
mesh_terms: D000818:Animals; D001483:Base Sequence; D015683:Gene Products, gag / Q000235:genetics* / Q000378:metabolism; D014644:Genetic Variation; D006239:Haplotypes; D016086:Lentivirus / Q000235:genetics*; D016180:Lentivirus Infections / Q000662:veterinary* / Q000821:virology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017384:Sequence Deletion; D012756:Sheep; D012757:Sheep Diseases / Q000821:virology*
chemical_list: D015683:Gene Products, gag