title: Palladium-catalyzed highly efficient synthesis of functionalized indolizines via cross-coupling/cycloisomerization cascade.
abstract: An efficient Pd-catalyzed cross-coupling/cycloisomerization of 3-(2-pyridyl) propargyl carbonates with organoboronic acids has been developed, which provides a straightforward route for the synthesis of 1,3-disubstituted indolizines with a wide variety of substituents. The mechanistic study indicates that the reaction proceeds via formation of an allenyl pyridine intermediate through palladium-catalyzed coupling reaction followed by cyclization.
authors.affiliation: Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang Road, Nanjing 210009, China. zhangdayong@cpu.edu.cn.
authors.forename: Liangwei
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
authors.forename: Dayong
authors.initials: D
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D007536:Isomerism; D010165:Palladium / Q000737:chemistry*
chemical_list: D007212:Indolizines; D010165:Palladium