title: Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis.
abstract: Amyotrophic lateral sclerosis is a progressive neurodegenerative disease of the motor neurons without a known cure. Based on the possibility of cellular neuroprotection and early preclinical results, stem cells have gained widespread enthusiasm as a potential treatment strategy. Preclinical models demonstrate a protective role of engrafted stem cells and provided the basis for human trials carried out using various types of stem cells, as well as a range of cell delivery methods. To date, no trial has demonstrated a clear therapeutic benefit; however, results remain encouraging and are the basis for ongoing studies. In addition, stem cell technology continues to improve, and induced pluripotent stem cells may offer additional therapeutic options in the future. Improved disease models and clinical trials will be essential in order to validate stem cells as a beneficial therapy.
authors.affiliation: Department of Neurology, University of Michigan, F2647 UH South, SPC 5223, 1500 East Medical Center Drive, Ann Arbor, MI, 48109-5036, USA, sgoutman@med.umich.edu.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Goutman
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Chen
authors.forename: Eva L
authors.initials: EL
authors.lastname: Feldman
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000601:surgery*; D000818:Animals; D006801:Humans; D039904:Pluripotent Stem Cells / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends*