title: Semi-quantitative vs. volumetric determination of endolymphatic space in Menière's disease using endolymphatic hydrops 3T-HR-MRI after intravenous gadolinium injection.
abstract: Magnetic resonance imaging enhances the clinical diagnosis of Menière's disease. This is accomplished by in vivo detection of endolymphatic hydrops, which are graded using different semi-quantitative grading systems. We evaluated an established, semi-quantitative endolymphatic hydrops score and with a quantitative method for volumetric assessment of the endolymphatic size. 11 patients with Menière's disease and 2 healthy subjects underwent high resolution endolymphatic hydrops 3 Tesla MRI with highly T2 weighted FLAIR and T2DRIVE sequences. The degree of endolymphatic hydrops was rated semi-quantitatively and compared to the results of 3D-volumetry. Moreover, the grade of endolymphatic hydrops was correlated with pure tone audiometry. Semi-quantitative grading and volumetric evaluation of the endolymphatic hydrops are in accordance (r = 0.92) and the grade of endolymphatic hydrops correlates with pure tone audiometry. Patients with a sickness duration of ≥ 30 months showed a significant higher total labyrinth fluid volume (p = 0.03). Fast, semi-quantitative evaluation of endolymphatic hydrops is highly reliable compared to quantitative/volumetric assessment. Endolymphatic space is significantly higher in patients with longer sickness duration.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Homann
authors.affiliation: Department of Clinical Radiology, University Hospital Münster, Münster, Germany.
authors.forename: Volker
authors.initials: V
authors.lastname: Vieth
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Münster, Münster, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Weiss
authors.affiliation: Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Nikolaou
authors.affiliation: Department of Clinical Radiology, University Hospital Münster, Münster, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Heindel
authors.affiliation: Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Tübingen, Germany.
authors.forename: Mike
authors.initials: M
authors.lastname: Notohamiprodjo
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Münster, Münster, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Böckenfeld
mesh_terms: D001301:Audiometry, Pure-Tone; D004710:Endolymph / Q000378:metabolism*; D005682:Gadolinium / Q000494:pharmacology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008575:Meniere Disease / Q000175:diagnosis* / Q000473:pathology*; D018709:Statistics, Nonparametric
chemical_list: D005682:Gadolinium