title: Effect of local chain dynamics on a bioinert interface.
abstract: Although many kinds of synthetic polymers have been investigated to construct blood-compatible materials, only a few have achieved success. To establish molecular designs for blood-compatible polymers, the chain structure and dynamics at the water interface must be understood using solid evidence as the first bench mark. Here we show that polymer dynamics at the water interface impacts on structure of the interfacial water, resulting in a change in protein adsorption and of platelet adhesion. As a particular material, a blend composed of poly(2-methoxyethyl acrylate) (PMEA) and poly(methyl methacrylate) was used. PMEA was segregated to the water interface. While the local conformation of PMEA at the water interface was insensitive to its molecular weight, the local dynamics became faster with decreasing molecular weight, resulting in a disturbance of the network structure of waters at the interface. This leads to the extreme suppression of protein adsorption and platelet adhesion.
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Hirata
authors.forename: Hisao
authors.initials: H
authors.lastname: Matsuno
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawaguchi
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hirai
authors.affiliation: ∥Neutron Science Laboratory, High Energy Accelerator Research Organization, Ibaraki 305-0801, Japan.
authors.forename: Norifumi L
authors.initials: NL
authors.lastname: Yamada
authors.affiliation: ⊥Department of Biochemical Engineering, Yamagata University, Yamagata 992-8510, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000179:Acrylates / Q000737:chemistry* / Q000494:pharmacology; D000327:Adsorption; D000818:Animals; D002417:Cattle; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D009038:Motion; D010973:Platelet Adhesiveness / Q000187:drug effects; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D013499:Surface Properties; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000179:Acrylates; D011108:Polymers; D011506:Proteins; C413485:poly(2-methoxyethylacrylate); D014867:Water; D019904:Polymethyl Methacrylate