title: Hyperpolarized 15N-pyridine derivatives as pH-sensitive MRI agents.
abstract: Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH would have diagnostic and prognostic value for many diseases. Here, we report an investigation of hyperpolarized (15)N-pyridine derivatives as ultrasensitive pH-sensitive imaging probes. These molecules are easily polarized to high levels using standard dynamic nuclear polarization (DNP) techniques and their (15)N chemical shifts were found to be highly sensitive to pH. These probes displayed sharp (15)N resonances and large differences in chemical shifts (Δδ > 90 ppm) between their free base and protonated forms. These favorable features make these agents highly suitable candidates for the detection of small changes in tissue pH near physiological values.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Weina
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Lloyd
authors.initials: L
authors.lastname: Lumata
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Shanrong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kovacs
authors.affiliation: 1] Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA [2] Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75083, USA.
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors.forename: Chalermchai
authors.initials: C
authors.lastname: Khemtong
mesh_terms: D003287:Contrast Media; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D009587:Nitrogen Isotopes; D011725:Pyridines / Q000737:chemistry
chemical_list: D003287:Contrast Media; D009587:Nitrogen Isotopes; D011725:Pyridines; C023666:pyridine