title: Advancing the delivery of anticancer drugs: Conjugated polymer/triterpenoid composite.
abstract: Exemplifying the synergy of anticancer properties of triterpenoids and ion retention qualities of conjugated polymers, we propose a conducting matrix to be a reservoir of anticancer compounds. In this study, poly(3,4-ethylenedioxythiophene), PEDOT, based matrix for electrically triggered and local delivery of the ionic form of anticancer drug, oleanolic acid (HOL), has been investigated. An initial, one-step fabrication procedure has been proposed, providing layers exhibiting good drug release properties and biological activity. Investigation of obtained systems and implementation of modifications revealed another route of fabrication. This procedure was found to yield layers possessing a significantly greater storage capacity of OL(-), as evidenced by the 52% increase in the drug concentrations attainable through electro-assisted release. Examination of the biological activity of immobilised and released OL(-) molecules proved that electrochemical treatment has negligible impact on the anticancer properties of OL(-), particularly when employing the three-step procedure, in which the range of applied potentials is limited. PEDOT/OL(-) composite has been demonstrated to be a robust and cost-effective material for controlled drug delivery.
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: katarzyna.krukiewicz@polsl.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Krukiewicz
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: tomasz.jarosz@polsl.pl.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jarosz
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: jerzy.zak@polsl.pl.
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Zak
authors.affiliation: Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland. Electronic address: mieczyslaw.lapkowski@polsl.pl.
authors.forename: Mieczyslaw
authors.initials: M
authors.lastname: Lapkowski
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 5, 60-806 Poznan, Poland. Electronic address: pruszkowski@gmail.com.
authors.forename: Piotr
authors.initials: P
authors.lastname: Ruszkowski
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Poznan University of Medical Sciences, Rokietnicka 5, 60-806 Poznan, Poland. Electronic address: tbobkiew@ump.edu.pl.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bobkiewicz-Kozlowska
authors.affiliation: Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland. Electronic address: bcwynar@ump.edu.pl.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bednarczyk-Cwynar
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry*; D004058:Diffusion; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009828:Oleanolic Acid / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D058726:Nanoconjugates; D011108:Polymers; D014315:Triterpenes; C121383:poly(3,4-ethylene dioxythiophene); D009828:Oleanolic Acid
keywords: Anticancer activity; Conducting polymer; Drug delivery; Oleanolic acid; Poly(3,4-ethylenedioxythiophene)