title: An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up.
abstract: Children with cows' milk protein allergy (CMPA) are at risk of insufficient length and weight gain, and the nutritional efficacy of hypo-allergenic formulas should be carefully assessed. In 2008, a trial assessed the impact of probiotic supplementation of an extensively hydrolysed casein-based formula (eHCF) on acquisition of tolerance in 119 infants with CMPA. First analysis of the study results showed that the studied formula allowed improvement of food-related symptoms. The scoring of atopic dermatitis (SCORAD) index was assessed at randomisation and after 6 months of feeding. A post hoc analysis was performed using WHO growth software's nutritional survey module (WHO Anthro version 3.2.2). All infants who were fed the study formula tolerated it well. The SCORAD index significantly improved from randomisation to 6 months of feeding with the study formula. Anthropometric data indicated a significant improvement in the weight-for-age, length-for-age and weight-for-length z scores, as well as in the restoration of normal BMI. The probiotic supplementation did not show any impact on these parameters. The present data showed that this eHCF was clinically tolerated and significantly improved the SCORAD index and growth indices.
authors.affiliation: Department of Pediatric Gastroenterology,Hepatology and Nutrition, Service d'Explorations Fonctionnelles Digestives Pédiatriques, Hôpital Necker-Enfants Malades,149 rue de Sèvres,75015Paris,France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dupont
authors.affiliation: Department of Pediatrics,St Elisabeth Hospital,Willemstad, Curaçao,The Netherlands Antilles.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hol
authors.affiliation: Department of Pediatrics,Wilhelmina Children's Hospital, University Medical Center Utrecht,Utrecht,The Netherlands.
authors.forename: Edward E S
authors.initials: EE
authors.lastname: Nieuwenhuis
mesh_terms: D001644:Bifidobacterium / Q000276:immunology; D015992:Body Mass Index; D002364:Caseins / Q000009:adverse effects / Q000627:therapeutic use*; D002657:Child Development; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D019648:Foods, Specialized / Q000009:adverse effects / Q000382:microbiology; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D041943:Infant Formula / Q000737:chemistry*; D007227:Infant Nutritional Physiological Phenomena; D007780:Lacticaseibacillus casei / Q000276:immunology; D059012:Lost to Follow-Up; D008297:Male; D016269:Milk Hypersensitivity / Q000178:diet therapy* / Q000276:immunology / Q000503:physiopathology; D009426:Netherlands / Q000453:epidemiology; D010352:Patient Dropouts; D019936:Probiotics / Q000627:therapeutic use; D012306:Risk; D013851:Thinness / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
chemical_list: D002364:Caseins; C475729:casein hydrolysate
keywords: Hypo-allergenic formulas