title: An elderly lady with significant weight loss.
abstract: We present a rare case of collagenous sprue in an elderly woman with significant weight loss and malnutrition. Collagenous sprue is a rare, female-predominant and immune-mediated gastrointestinal disease that can affect any part of the gut, and shares a strong association with Coeliac disease. The diagnosis is confirmed by gut histopathology demonstrating a subepithelial collagenous band and inflammatory infiltrate in the lamina propria. The pathogenesis and natural history is poorly elucidated, and treatment involves a gluten-free diet and/or immunomodulatory therapy.
authors.affiliation: Department of Medicine, Division of Gastroenterology, London Health Science Center, The University of Western Ontario London, Ontario, Canada; Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia; Department of Pathology, London Health Science Center, The University of Western Ontario London, Ontario, Canada. Electronic address: bandaraljudaibi@gmail.com.
authors.forename: Bandar
authors.initials: B
authors.lastname: Al-Judaibi
authors.affiliation: Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia; Department of Pathology, London Health Science Center, The University of Western Ontario London, Ontario, Canada.
authors.forename: David K
authors.initials: DK
authors.lastname: Driman
authors.affiliation: Department of Medicine, Division of Gastroenterology, London Health Science Center, The University of Western Ontario London, Ontario, Canada; Department of Pathology, London Health Science Center, The University of Western Ontario London, Ontario, Canada.
authors.forename: Natasha
authors.initials: N
authors.lastname: Chandok
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002446:Celiac Disease / Q000175:diagnosis* / Q000473:pathology; D064068:Collagenous Sprue / Q000175:diagnosis / Q000178:diet therapy* / Q000473:pathology*; D003937:Diagnosis, Differential; D055050:Diet, Gluten-Free; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology; D018570:Risk Assessment; D016896:Treatment Outcome; D015431:Weight Loss
keywords: Coeliac disease; Collagen band; Collagenous sprue