title: Three Year RSA Evaluation of Vitamin E Diffused Highly Cross-linked Polyethylene Liners and Cup Stability.
abstract: Vitamin E diffusion into highly cross-linked polyethylene (E-XLPE) is a method for enhancing oxidative stability of acetabular liners. The purpose of this study was to evaluate in vivo penetration of E-XLPE using radiostereometric analysis (RSA). Eighty-four hips were recruited into a prospective 10-year RSA. This is the first evaluation of the multicenter cohort after 3-years. All patients received E-XLPE liners (E1, Biomet) and porous-titanium coated cups (Regenerex, Biomet). There was no difference (P=0.450) in median femoral head penetration into the E-XLPE liners at 3-years comparing cobalt-chrome heads (-0.028mm; inter-quartile range (IQR) - 0.065 to 0.047) with ceramic heads (-0.043mm, IQR - 0.143to0.042). The 3-year follow-up indicates minimal E-XLPE liner penetration regardless of head material and minimal early cup movement.
authors.affiliation: Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts; Department of Orthopedics, Clinical Orthopedic Research Hvidovre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
authors.forename: Nanna H
authors.initials: NH
authors.lastname: Sillesen
authors.affiliation: Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Meridith E
authors.initials: ME
authors.lastname: Greene
authors.affiliation: Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Audrey K
authors.initials: AK
authors.lastname: Nebergall
authors.affiliation: Department of Orthopaedics, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Poul T
authors.initials: PT
authors.lastname: Nielsen
authors.affiliation: Department of Orthopaedics, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: Mogens B
authors.initials: MB
authors.lastname: Laursen
authors.affiliation: Department of Orthopedics, Clinical Orthopedic Research Hvidovre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Troelsen
authors.affiliation: Harris Orthopaedic Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
authors.forename: Henrik
authors.initials: H
authors.lastname: Malchau
mesh_terms: D000077:Acetabulum / Q000601:surgery; D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D002516:Ceramics; D002858:Chromium Alloys / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D005260:Female; D005270:Femur Head / Q000737:chemistry; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000737:chemistry; D061214:Patient Safety; D020959:Polyethylene / Q000737:chemistry*; D011446:Prospective Studies; D011474:Prosthesis Design; D011475:Prosthesis Failure; D059869:Radiostereometric Analysis / Q000379:methods*; D013997:Time Factors; D014025:Titanium; D014810:Vitamin E / Q000737:chemistry*
chemical_list: D002858:Chromium Alloys; D003432:Cross-Linking Reagents; D014810:Vitamin E; D003035:Cobalt; D020959:Polyethylene; D014025:Titanium; D010100:Oxygen
keywords: RSA; hip arthroplasty; liner; polyethylene; vitamin E