title: Coordination behavior of new bis Schiff base ligand derived from 2-furan carboxaldehyde and propane-1,3-diamine. Spectroscopic, thermal, anticancer and antibacterial activity studies.
abstract: Novel bis Schiff base ligand, [N1,N3-bis(furan-2-ylmethylene)propane-1,3-diamine], was prepared by the condensation of furan-2-carboxaldehyde with propane-1,3-diamine. Its conformational changes on complexation with transition metal ions [Co(II), Ni(II), Cu(II), Mn(II), Cd(II), Zn(II) and Fe(III)] have been studied on the basis of elemental analysis, conductivity measurements, spectral (infrared, (1)H NMR, electronic), magnetic and thermogravimetric studies. The conductance data of the complexes revealed their electrolytic nature suggesting them as 1:2 (for bivalent metal ions) and 1:3 (for Fe(III) ion) electrolytes. The complexes were found to have octahedral geometry based on magnetic moment and solid reflectance measurements. Thermal analysis data revealed the decomposition of the complexes in successive steps with the removal of anions, coordinated water and bis Schiff base ligand. The thermodynamic parameters were calculated using Coats-Redfern equation. The Anticancer screening studies were performed on human colorectal cancer (HCT), hepatic cancer (HepG2) and breast cancer (MCF-7) cell lines. The antimicrobial activity of all the compounds was studied against Gram negative (Escherichia coli and Proteus vulgaris) and Gram positive (Bacillus vulgaris and Staphylococcus pyogones) bacteria. It was observed that the coordination of metal ion has a pronounced effect on the microbial activities of the bis Schiff base ligand. All the metal complexes have shown higher antimicrobial effect than the free bis Schiff base ligand.
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address: ggenidy68@hotmail.com.
authors.forename: Gehad G
authors.initials: GG
authors.lastname: Mohamed
authors.affiliation: Green Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
authors.forename: Ehab M
authors.initials: EM
authors.lastname: Zayed
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: Ahmed M M
authors.initials: AMM
authors.lastname: Hindy
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry*; D004553:Electric Conductivity; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005663:Furans / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D060328:Magnetic Phenomena; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D003959:Diamines; D005663:Furans; D008024:Ligands; C000604100:N1,N3-bis(furan-2-ylmethylene)propane-1,3-diamine; D012545:Schiff Bases; C009475:trimethylenediamine
keywords: Antibacterial activity; Anticancer activity; Schiff base ligand; Spectroscopy; Transition metal complexes