title: IAPs and cell migration.
abstract: Inhibitors of apoptosis (IAPs) constitute a family of cell signaling regulators controlling several fundamental biological processes such as innate immunity, inflammation, cell death, cell proliferation, and cell differentiation. Increasing evidence from in vivo and in vitro studies indicate a function for IAPs in the modulation of invasive and migratory properties of cells. Here, we present and discuss the mechanisms whereby IAPs can control cell migration.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (Inserm) UMR866, Dijon F-21079, France; Université de Bourgogne, Dijon F-21079, France. Electronic address: ldubrez@u-bourgogne.fr.
authors.forename: Laurence
authors.initials: L
authors.lastname: Dubrez
authors.affiliation: Molecular Signaling Unit, FZI, Institute for Immunology, JGU University Medical Center, Langenbeck Str. 1, 55131 Mainz, Germany; Institute for Biochemistry II, Goethe University Medical School, Frankfurt, Germany. Electronic address: Krishna@uni-mainz.de.
authors.forename: Krishnaraj
authors.initials: K
authors.lastname: Rajalingam
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051034:Inhibitor of Apoptosis Proteins
keywords: IAPs; Invasion; Migration; RhoGTPases; Signaling; Ubiquitination