title: [Radiation-induced reactions in breast cancer patients after breast-conserving surgery with intraoperative and external beam radiotherapy].
abstract: The present study is aimed to evaluate the frequency and severity of radiation-induced reactions in patients with stage T1-2N0-1M0 breast cancer, who received intraopeartive radiation therapy (IORT) in combination with external beam radiotherapy (EBRT). A small-size betatron producing 6 MeV electron beam was used for IORT. External beam radiotherapy was performed using Rokus and Theratron machines. Radiotherapy treatment was planned using a specially devised method to ensure acceptable levels of severity and frequency of radiation reactions. The patients were divided into 3 groups: the study (40 patients), control (88) and comparison (50) ones. Radiation-induced skin reactions in the study group ranged from erythema to moist desquamation and edema. Magnetic laser therapy was used to treat radiation-induced injuries. The applied method of estimating the total dose of IORT and EBRT was shown to provide the acceptable levels of severity and frequency of radiation reactions.
authors.forename: L I
authors.initials: LI
authors.lastname: Musabaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Lisin
authors.forename: V V
authors.initials: VV
authors.lastname: Velikaia
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000628:therapy; D011832:Radiation Injuries / Q000473:pathology*; D011879:Radiotherapy Dosage