title: Behavioral, hormonal, and neurotransmitter reactions to stress in adult rats with a history of high IL-1β content in the early postnatal ontogeny.
abstract: Behavioral, hormonal, and neurotransmitter reactions to foot shock were studied in adult rats treated with IL-1β during week 3 of life. After stress, these animals differed from controls treated with saline by high levels of dopamine, serotonin, and 5-hydroxy-indolacetic acid in the hypothalamus. In contrast to controls, they developed a significant stress-induced increase of blood corticosterone level and exhibited lesser motor and exploratory activities in the open field test.
authors.affiliation: Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia, zubarevaoe@mail.ru.
authors.forename: O E
authors.initials: OE
authors.lastname: Zubareva
authors.forename: A P
authors.initials: AP
authors.lastname: Schwartz
authors.forename: L K
authors.initials: LK
authors.lastname: Khnychenko
authors.forename: A M
authors.initials: AM
authors.lastname: Ishchenko
authors.forename: A S
authors.initials: AS
authors.lastname: Simbirtsev
authors.forename: V M
authors.initials: VM
authors.lastname: Klimenko
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000097:blood; D007031:Hypothalamus / Q000378:metabolism; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D018377:Neurotransmitter Agents / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000097:blood; D013315:Stress, Psychological / Q000097:blood* / Q000503:physiopathology
chemical_list: D053583:Interleukin-1beta; D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine; D003345:Corticosterone