title: Role of tumor-associated glycoprotein-72 in the progression of endometrial adenocarcinoma: a proposed study.
abstract: Endometrial adenocarcinoma is on the basis of the molecular, immunohistological and clinicopathologic features broadly divided into two groups, referred as type I and type II. Type I appears more frequently and in principle patients have a good prognosis; however a significant number of patients develop local recurrences. We hypothesize that TAG-72, expressed on endometrial carcinoma binds and internalizes endocytic pattern recognition receptors on surrounding tissue antigen presenting cells (dendritic cells and macrophages), powers their anti-inflammatory maturation program and make them capable to elicit or modulated tolerogenic immune response mediated by local T and NK effectors. This could support uncontrolled local tumor growth, deeper tumor invasion into surrounding tissues, frequent local recurrences and/or lymph node metastasis. To test this hypothesis, we propose a semi-quantitative immunohistochemical analysis of TAG-72 expression in endometrial adenocarcinoma samples and to correlate the results with clinical and pathological parameters (age, type and histological grade of the tumor, estrogen and progesterone receptor expression, invasion into the myometrium and capillaries, presence of lymph node metastases, FIGO stage, and TNM classification). It would be worthwhile to investigate the local tissue immune response in the tumor environment using tissue samples removed during surgery. These studies could elucidate the underlying immunopathological mechanisms that govern the early recurrence and possibly distant metastases of TAG-72-expressing adenocarcinomas and might help in deciding the type of treatment to be applied in a selected group of cancer patients including application of biological therapy with anti-TAG-72 antibodies, according the principle of personalized oncology treatments.
authors.affiliation: Department of Obstetrics and Gynecology, Clinical Hospital, University of Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
authors.forename: Ines
authors.initials: I
authors.lastname: Kristofic
authors.affiliation: Department of Radiotherapy and Oncology, Clinical Hospital, University of Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
authors.forename: Arnela
authors.initials: A
authors.lastname: Redzovic
authors.affiliation: Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia; Hospital for Medical Rehabilitation of the Hearth and Lung Diseases and Rheumatism, "Thalassotherapija" Opatija, M. Tita 188, 51410 Opatija, Croatia. Electronic address: gordana.laskarin@medri.uniri.hr.
authors.forename: Gordana
authors.initials: G
authors.lastname: Laskarin
authors.affiliation: Department of Pathology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia.
authors.forename: Senija
authors.initials: S
authors.lastname: Eminovic
authors.affiliation: Department of Obstetrics and Gynecology, Clinical Hospital, University of Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
authors.forename: Herman
authors.initials: H
authors.lastname: Haller
authors.affiliation: Department of Physiology and Immunology, Medical Faculty, University of Rijeka, B. Branchetta 20, 51000 Rijeka, Croatia; Department of Clinical and Transplantation Immunology and Molecular Medicine in Rijeka, Croatian Academy of Sciences and Arts, R. Matejcic 2, Rijeka, Croatia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rukavina
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D018450:Disease Progression; D016889:Endometrial Neoplasms / Q000276:immunology / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D018448:Models, Immunological; D057285:Precision Medicine / Q000379:methods
chemical_list: D000951:Antigens, Neoplasm; D006023:Glycoproteins; C047052:tumor-associated antigen 72