title: miR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells.
abstract: Endometriosis is associated with severe pelvic pain and reduced fertility. Recently, it has been linked to a dysregulation of microRNAs (miRNAs), which are post-transcriptional regulators of gene expression. The functional effect of dysregulated miR-142-3p expression in endometrial stroma cells was investigated. An increased expression of miR-142-3p resulted in a significantly reduced expression of steroid sulfatase and interleukin-6-coreceptor gp130 as well as reduced interleukin-6-mediated activation of the STAT3-pathway, suggesting an effect of miR-142-3p both on steroid hormone- and cytokine-mediated signalling events. At the functional level, miR-142-3p overexpression significantly reduced cell viability (P ≤ 0.01). miR-142-3p regulation emerges as a future therapeutic strategy for endometriosis.
authors.affiliation: Department of Gynaecology and Obstetrics, Münster University Hospital, Münster 48149, Germany.
authors.forename: Christin Susanna
authors.initials: CS
authors.lastname: Kästingschäfer
authors.affiliation: Department of Gynaecology and Obstetrics, Münster University Hospital, Münster 48149, Germany.
authors.forename: Sebastian Daniel
authors.initials: SD
authors.lastname: Schäfer
authors.affiliation: Department of Gynaecology and Obstetrics, Münster University Hospital, Münster 48149, Germany.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kiesel
authors.affiliation: Department of Gynaecology and Obstetrics, Münster University Hospital, Münster 48149, Germany. Electronic address: martingotte@uni-muenster.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Götte
mesh_terms: D002470:Cell Survival / Q000502:physiology*; D004717:Endometrium / Q000166:cytology* / Q000378:metabolism; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: C555159:MIRN142 microRNA, human; D035683:MicroRNAs
keywords: STAT3; endometriosis; interleukin; microRNA; pathogenesis; steroid sulfatase