title: Hepatoprotective benzofurans and furanolignans from Gymnema tingens.
abstract: Two new benzofurans, gymnefuranols A (1) and B (2), together with six known furanolignans (3-8), were isolated from Gymnema tingens. The structures of the new compounds were elucidated by comprehensive analysis of the NMR and HR-MS data. Compounds 1, 2, 6, and 7 showed hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Material Medica , Beijing 100050 , China.
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Yan-Gai
authors.initials: YG
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Yang
authors.forename: Ligang
authors.initials: L
authors.lastname: Zhou
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ji
authors.forename: Ai-Guo
authors.initials: AG
authors.lastname: Wang
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005688:Galactosamine / Q000494:pharmacology; D031103:Gymnema / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D001572:Benzofurans; D017705:Lignans; C000598451:gymnefuranol A; C000598452:gymnefuranol B; D005688:Galactosamine
keywords: Asclepiadaceae; Gymnema tingens; benzofuran; furanolignan; hepatoprotective; structure elucidation