title: Overview of proteomics studies in obstructive sleep apnea.
abstract: Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar Lisboa Norte, E.P.E., Lisboa, Portugal; Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
authors.forename: Amélia
authors.initials: A
authors.lastname: Feliciano
authors.affiliation: Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
authors.forename: Vukosava Milic
authors.initials: VM
authors.lastname: Torres
authors.affiliation: Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
authors.forename: Fátima
authors.initials: F
authors.lastname: Vaz
authors.affiliation: Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
authors.forename: Ana Sofia
authors.initials: AS
authors.lastname: Carvalho
authors.affiliation: Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal.
authors.forename: Rune
authors.initials: R
authors.lastname: Matthiesen
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar Lisboa Norte, E.P.E., Lisboa, Portugal.
authors.forename: Paula
authors.initials: P
authors.lastname: Pinto
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, CA, USA; Division of Sleep Medicine Sleep Disorders Research Program Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Malhotra
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar Lisboa Norte, E.P.E., Lisboa, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Bárbara
authors.affiliation: Laboratório de Proteómica, Departamento de Genética Humana, Instituto Nacional de Saúde, Dr. Ricardo Jorge I.P., Lisboa, Portugal. Electronic address: deborah.penque@insa.min-saude.pt.
authors.forename: Deborah
authors.initials: D
authors.lastname: Penque
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D006801:Humans; D040901:Proteomics / Q000379:methods; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000175:diagnosis* / Q000652:urine
chemical_list: D015415:Biomarkers
keywords: Biomarkers; Lung; Mass spectrometry; Metabolic disorders; Obstructive sleep apnea; Proteomics