title: Interventions for treating intrahepatic cholestasis in people with sickle cell disease.
abstract: BACKGROUND
  Sickle cell disease is the most common hemoglobinopathy occurring worldwide and sickle cell intrahepatic cholestasis is a complication long recognized in this population. Cholestatic liver diseases are characterized by impaired formation or excretion (or both) of bile from the liver. There is a need to assess the clinical benefits and harms of the interventions used to treat intrahepatic cholestasis in people with sickle cell disease.
  
  
  OBJECTIVE
  To assess the benefits and harms of the interventions for treating intrahepatic cholestasis in people with sickle cell disease.
  
  
  METHODS
  We searched the Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register, which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings. We also searched the LILACS database (1982 to 7 July 2014) and the WHO International Clinical Trials Registry Platform Search Portal (7 July 2014).Date of last search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Haemoglobinopathies Trials Register: 10 October 2014.
  
  
  METHODS
  We searched for published or unpublished randomised controlled trials.
  
  
  METHODS
  Each author intended to independently extract data and assess the risk of bias of the trials by standard Cochrane Collaboration methodologies; however, no trials were included in the review.
  
  
  RESULTS
  There were no randomised controlled trials identified.
  
  
  CONCLUSIONS
  This Cochrane Review did not identify any randomised controlled trials assessing interventions for treating intrahepatic cholestasis in people with sickle cell disease. Randomised controlled trials are needed to establish the optimum treatment for this condition.
authors.affiliation: Iberoamerican Cochrane Network, Valencia, Venezuela.
authors.forename: Arturo J
authors.initials: AJ
authors.lastname: Martí-Carvajal
authors.forename: Daniel
authors.initials: D
authors.lastname: Simancas-Racines
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D002780:Cholestasis, Intrahepatic / Q000209:etiology / Q000628:therapy*; D006801:Humans