title: Cp2TiCl2-catalyzed cis-hydroalumination of propargylic amines with Red-Al: stereoselective synthesis of Z-configured allylic amines.
abstract: A titanium-catalyzed cis-hydroalumination of propargylic amines with Red-Al is described, which provides an efficient way to produce Z-configured allylic amines in good to excellent yields with high stereoselectivity and good regioselectivity. The hydride-bridged Al/Ti bimetallic species may act as a real catalyst in this reaction.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China. yhliu@sioc.ac.cn.
authors.forename: Renhong
authors.initials: R
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Shuang
authors.initials: S
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Sun
authors.forename: Haoyi
authors.initials: H
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Xu
authors.initials: X
authors.lastname: You
authors.forename: Shi
authors.initials: S
authors.lastname: Li
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009942:Organometallic Compounds; D011437:Propylamines; C007396:dihydrobis(2-methoxyethoxy)aluminate; C009054:propargylamine; D010293:Pargyline; C020528:titanocene dichloride