title: Treatment of early-onset preeclampsia with continuous positive airway pressure.
abstract: BACKGROUND
  Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality. There is no treatment for preeclampsia other than delivery. Sleep-disordered breathing is associated with adverse pregnancy outcomes, including preeclampsia, but it is not known whether treatment with continuous positive airway pressure (CPAP) improves perinatal outcomes.
  
  
  METHODS
  We report a 35-year-old primigravid woman diagnosed with preeclampsia at 30 weeks of gestation. A sleep study confirmed severe sleep-disordered breathing, and CPAP treatment was started. After CPAP treatment, both clinical and biochemical markers of preeclampsia improved. In addition, circulating angiogenic markers of preeclampsia improved. As a result, the pregnancy safely continued for 30 days, allowing the fetus to gain gestation.
  
  
  CONCLUSIONS
  Continuous positive airway pressure may be a novel treatment for women with early-onset preeclampsia associated with sleep-disordered breathing.
authors.affiliation: Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, the Department of Respiratory and Sleep Medicine, Austin Hospital, and the Department of Obstetrics and Gynaecology, University of Melbourne, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
authors.forename: Clare
authors.initials: C
authors.lastname: Whitehead
authors.forename: Stephen
authors.initials: S
authors.lastname: Tong
authors.forename: Danielle
authors.initials: D
authors.lastname: Wilson
authors.forename: Mark
authors.initials: M
authors.lastname: Howard
authors.forename: Susan P
authors.initials: SP
authors.lastname: Walker
mesh_terms: D000328:Adult; D015897:Comorbidity; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000503:physiopathology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012891:Sleep Apnea Syndromes / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy