title: [Remodeling of heart and neutrophil intracellular metabolism in obese men].
abstract: OBJECTIVE
  To study remodeling of heart and its influence on intracellular metabolism of neutrophils in obese men.
  
  
  METHODS
  85 men aged 30-63 years free from coronary heart disease underwent ECG examination with the evaluation of diastolic properties and diagnostics of left ventricle remodeling with special reference to oxygen-dependent metabolism and antioxidant protection of neutrophils.
  
  
  CONCLUSIONS
  Increased degree of obesity in men leads to enhanced frequency of diastolic dysfunction and left ventricular myocardium remodeling accompanied by a rise in myeloperoxidase activity in neutrophils. The latter was especially high in patients with concentric hypertrophy of left ventricular myocardium.
  
  
  CONCLUSIONS
  Increased degree of heart remodeling with enhanced severity of obesity in men is accompanied by activation of oxygen-dependent metabolism in neutrophils.
authors.forename: A E
authors.initials: AE
authors.lastname: Kratnov
authors.forename: E V
authors.initials: EV
authors.lastname: Timganova
authors.forename: E V
authors.initials: EV
authors.lastname: Koroleva
mesh_terms: D000328:Adult; D054144:Heart Failure, Diastolic / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D018384:Oxidative Stress; D012720:Severity of Illness Index; D013223:Statistics as Topic; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D020257:Ventricular Remodeling