title: Differential distribution of probenecid as detected by on-tissue mass spectrometry.
abstract: We demonstrate, by means of on-tissue mass spectrometry of tissue sections, that the drug probenecid can penetrate the blood-brain barrier. This method holds general promise for the detection and distribution of small molecule drugs within organ and tissue compartments.
authors.affiliation: Institute for Bioanalytical Chemistry, Saarland University, Kirrberger Straße, Trigonum Vesalii, 66424, Homburg, Saar, Germany.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Qi
authors.forename: Nadine
authors.initials: N
authors.lastname: Hainz
authors.forename: Thomas
authors.initials: T
authors.lastname: Tschernig
authors.forename: Carola
authors.initials: C
authors.lastname: Meier
authors.forename: Dietrich A
authors.initials: DA
authors.lastname: Volmer
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D009928:Organ Specificity / Q000187:drug effects; D011339:Probenecid / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000277:Adjuvants, Pharmaceutic; D011339:Probenecid