title: PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity.
abstract: Porcine reproductive and respiratory disease virus (PRRSV) has the intrinsic ability to adapt and evolve. After 25 years of study, this persistent pathogen has continued to frustrate efforts to eliminate infection of herds through vaccination or other elimination strategies. The purpose of this review is to summarize the research on the virion structure, replication and recombination properties of PRRSV that have led to the extraordinary phenotype and genotype diversity that exists worldwide.
authors.affiliation: Virus and Prion Research Unit, USDA-ARS-National Animal Disease Center, Ames, IA, USA.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Kappes
authors.affiliation: Virus and Prion Research Unit, USDA-ARS-National Animal Disease Center, Ames, IA, USA. Electronic address: kay.faaberg@ars.usda.gov.
authors.forename: Kay S
authors.initials: KS
authors.lastname: Faaberg
mesh_terms: D000818:Animals; D014644:Genetic Variation; D005838:Genotype; D010641:Phenotype; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure*; D011995:Recombination, Genetic; D014771:Virion / Q000648:ultrastructure; D014779:Virus Replication
keywords: Arterivirus; Heteroclite; Porcine reproductive and respiratory syndrome virus; Recombination; Replication; Subgenomic RNA