title: Detection of small brain metastases at 3 T: comparing the diagnostic performances of contrast-enhanced T1-weighted SPACE, MPRAGE, and 2D FLASH imaging.
abstract: The aim of this study was to compare the diagnostic performance of contrast-enhanced T1-weighted sampling perfection with application-optimized contrasts using different flip angle evolutions (SPACE), magnetization-prepared rapid gradient-echo (MPRAGE), and two-dimensional (2D) fast low angle shot (FLASH) for the detection of small brain metastases. Twelve patients who had brain metastases less than 10 mm in diameter were enrolled. The diagnostic performance was evaluated using alternative free-response receiver operating characteristic analysis. Sensitivity and positive predictive value were also calculated. The mean Az and sensitivities of SPACE for all observers were significantly higher than those of MPRAGE and 2D FLASH.
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital.
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Kwak
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital. Electronic address: sbh1010@jbnu.ac.kr.
authors.forename: Seungbae
authors.initials: S
authors.lastname: Hwang
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea; Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital.
authors.forename: Gyung-Ho
authors.initials: GH
authors.lastname: Chung
authors.affiliation: Department of Radiology, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Song
authors.affiliation: Department of Radiology, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712, Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Choi
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
keywords: 3 Tesla; Brain; Magnetic resonance imaging; Neoplasm metastasis; SPACE