title: Mapping of somatostatin-28 (1-12) in the alpaca (Lama pacos) brainstem.
abstract: Using an indirect immunoperoxidase technique, we studied the distribution of cell bodies and fibers containing somatostatin-28 (1-12) in the alpaca brainstem. Immunoreactive fibers were widely distributed throughout the whole brainstem: 34 brainstem nuclei/regions showed a high or a moderate density of these fibers. Perikarya containing the peptide were widely distributed throughout the mesencephalon, pons and medulla oblongata. Cell bodies containing somatostatin-28 (1-12) were observed in the lateral and medial divisions of the marginal nucleus of the brachium conjunctivum, reticular formation (mesencephalon, pons and medulla oblongata), inferior colliculus, periaqueductal gray, superior colliculus, pericentral division of the dorsal tegmental nucleus, interpeduncular nucleus, nucleus of the trapezoid body, vestibular nucleus, motor dorsal nucleus of the vagus, nucleus of the solitary tract, nucleus praepositus hypoglossi, and in the substantia nigra. This widespread distribution indicates that somatostatin-28 (1-12) is involved in multiple physiological actions in the alpaca brainstem.
authors.affiliation: Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems, University of Salamanca, Salamanca, Spain.
authors.forename: Eliana
authors.initials: E
authors.lastname: De Souza
authors.forename: Manuel Lisardo
authors.initials: ML
authors.lastname: Sánchez
authors.forename: Luís Ángel
authors.initials: LÁ
authors.lastname: Aguilar
authors.forename: Zaida
authors.initials: Z
authors.lastname: Díaz-Cabiale
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Narváez
authors.forename: Rafael
authors.initials: R
authors.lastname: Coveñas
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000737:chemistry*; D002161:Camelids, New World / Q000502:physiology*; D007150:Immunohistochemistry; D010446:Peptide Fragments / Q000032:analysis*; D053561:Somatostatin-28 / Q000032:analysis*
chemical_list: D010446:Peptide Fragments; D053561:Somatostatin-28; C037197:somatostatin 28-(1-12)
keywords: camelids; immunocytochemistry; medulla oblongata; mesencephalon; pons