title: The impact of a pure protein load on the glucose levels in type 1 diabetes patients treated with insulin pumps.
abstract: We aimed to estimate the impact of ingestion of a pure protein load on the glucose levels in T1DM patients treated with insulin pumps. We examined 10 T1DM patients (6 females, mean age-32.3 years, mean HbA1c-6.8%) treated with insulin pumps equipped with a continuous glucose monitoring system (CGMS). In Phase I, baseline insulin infusion was optimized to minimize the differences in fasting glucose levels to less than 30 mg/dL between any two time points between 9 a.m. and 3 p.m. In Phase II, the patients were exposed to single pure protein load. CGMS record was performed and the glucose pattern was defined for 6 hours of each phase. The maximal glucose level increment was similar for the entire duration of the fasting and the protein load test (26.6 versus 27.6 mg/dL, resp., P < 0.78). There was only a borderline difference in change between baseline versus 6th hour glucose (12.5 and 19.0 mg/dL, P = 0.04). Glucose variability, assessed by standard deviation of mean glucose levels, was 36.4 and 37.9 mg/dL, respectively (P = 0.01). The administration of a pure protein load does not seem to have a clinically significant impact on glucose levels in T1DM patients treated with insulin pumps.
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland ; University Hospital, Krakow, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Klupa
authors.affiliation: DiabWay Enterprise, Krakow, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Benbenek-Klupa
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland ; University Hospital, Krakow, Poland.
authors.forename: Bartlomiej
authors.initials: B
authors.lastname: Matejko
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Sandra
authors.initials: S
authors.lastname: Mrozinska
authors.affiliation: Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland ; University Hospital, Krakow, Poland.
authors.forename: Maciej T
authors.initials: MT
authors.lastname: Malecki