title: A case of orbital metastasis as disease progression of anaplastic lymphoma kinase-positive lung cancer treated with crizotinib.
abstract: Orbital metastasis of lung cancer is rare. It often causes visual disorder. To date, there are only a few case reports. Crizotinib is an anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor that leads to responses in most patients with ALK-positive non-small-cell lung cancer. Visual disorder is one of the popular adverse events of crizotinib, but the symptom almost decreases over time. We report a case of orbital metastasis as the disease progression of ALK-positive lung cancer treated with crizotinib. It should be kept in mind that orbital metastasis can be the disease progression of lung adenocarcinoma with ALK translocation treated with crizotinib. When physicians encounter a patient receiving crizotinib with visual disorder, we must distinguish between adverse events and orbital metastasis.
authors.affiliation: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Sakata
authors.affiliation: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Kodai
authors.initials: K
authors.lastname: Kawamura
authors.affiliation: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Ichikado
authors.affiliation: Division of Respiratory Medicine, Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yoshioka
keywords: Adverse event; Anaplastic lymphoma kinase; Crizotinib; Lung adenocarcinoma; Lung cancer; Orbital metastasis