title: Three pairs of diastereoisomeric flavanone glycosides from Viscum articulatum.
abstract: Phytochemical examination of the leaves and stems of Viscum articulatum resulted in the isolation of three pairs of new flavanone glycosides, 2R/2S-viscarticulide A-C (1a/1b-3a/3b), together with eight known compounds (7-14). Their structures were established by extensive spectroscopic data analyses. The diastereoisomers were separated by HPLC on a chiral phase and the absolute configuration at C-2 was determined by circular dichroism (CD) spectra. The protective effects of compounds 1-3 against H2O2-induced cytotoxicity with EA.hy926 cells were tested. The results showed that compounds 1-3 improved the survival of EA.hy926 cells after H2O2 exposure at the tested concentrations.
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Haizhen
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Zhun
authors.initials: Z
authors.lastname: Hou
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China. Electronic address: rendom@sdu.edu.cn.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Ren
mesh_terms: D002460:Cell Line; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D028181:Viscum / Q000737:chemistry*
chemical_list: D044950:Flavanones; D047309:Flavones; D006027:Glycosides; D010936:Plant Extracts; C000598393:viscarticulide A; C000598394:viscarticulide B; C000598395:viscarticulide C
keywords: Circular dichroism; Cytoprotection; Diastereoisomers; Flavanone glycosides; Viscum articulatum