title: Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: a case-control study.
abstract: OBJECTIVE
  There is inconclusive evidence regarding the potential link between diabetes mellitus (DM) and colorectal cancer (CRC). Associations between type 2 DM and colorectal neoplasia (CRN; colorectal cancer and/or adenomas) have not been well studied in Hispanics, an ethnic minority at high risk for type 2 DM. This study aims to assess the association between type 2 DM and CRN in Hispanics.
  
  
  METHODS
  Hispanics with incident CRN and colonoscopy-negative controls from 2005 to 2009 were evaluated. Diagnosis of type 2 DM was established by previous medical diagnosis and/or use of DM treatments. Unconditional logistic regression was performed to estimate odds ratios for the association between type 2 DM and CRN.
  
  
  RESULTS
  A total of 451 participants (mean age 61.1±11.9years, 59.6 % men) were evaluated (218 with incident CRC, 77 with colorectal adenomas, and 156 colonoscopy-negative controls). The prevalence of type 2 DM in this study was 25.1%. After adjusting for potential confounding variables, women with type 2 DM were 2.74 (95% CI: 0.94-7.99) times more likely to have CRN and 4.83 times more likely to present with proximal colonic CRN (95% CI: 1.25-18.58) than women without type 2 DM. No statistically significant associations were found between type 2 DM and CRN among men.
  
  
  CONCLUSIONS
  An increased odds for CRN and proximal location of CRN was observed among Hispanic women with type 2 DM. Since DM is a highly prevalent disease in this population, adherence to routine CRC screening is of outmost importance.
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: Yaritza
authors.initials: Y
authors.lastname: Díaz-Algorri
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Lozada
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: Sofía M
authors.initials: SM
authors.lastname: López
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Bertrán-Rodríguez
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: Cinthia M
authors.initials: CM
authors.lastname: González-Hernández
authors.affiliation: VA Caribbean Healthcare System Casia # 10 San Juan, P.R. 00921-3201.
authors.forename: Dilka
authors.initials: D
authors.lastname: González
authors.affiliation: University of Puerto Rico Graduate School of Public Health PO Box 365067 San Juan, P.R., 00936-5067.
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Pérez-Cardona
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346.
authors.forename: Jessica
authors.initials: J
authors.lastname: Hernández
authors.affiliation: VA Caribbean Healthcare System Casia # 10 San Juan, P.R. 00921-3201.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pedrosa
authors.affiliation: VA Caribbean Healthcare System Casia # 10 San Juan, P.R. 00921-3201.
authors.forename: Doris H
authors.initials: DH
authors.lastname: Toro
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346; University of Puerto Rico School of Medicine PO Box 365067 San Juan, P.R. 00936-5067.
authors.forename: María
authors.initials: M
authors.lastname: González-Pons
authors.affiliation: University of Puerto Rico Comprehensive Cancer Center, PMB 711 Ave. 89 Ste. 105, San Juan, P.R. 00927-6346; VA Caribbean Healthcare System Casia # 10 San Juan, P.R. 00921-3201; University of Puerto Rico School of Medicine PO Box 365067 San Juan, P.R. 00936-5067. Electronic address: marcia.cruz1@upr.edu.
authors.forename: Marcia
authors.initials: M
authors.lastname: Cruz-Correa
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D016022:Case-Control Studies; D003113:Colonoscopy / Q000706:statistics & numerical data; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
keywords: Colorectal adenomas; Colorectal cancer; Colorectal neoplasia; Hispanics; Type 2 DM; Type 2 diabetes