title: Microscopic polyangiitis associated with primary biliary cirrhosis, Sjogren's syndrome and Hashimoto's thyroiditis.
abstract: The association between microscopic polyangiitis (MPA) and primary biliary cirrhosis (PBC) has seldom been reported. We describe here a patient who presented with sensorimotor neuropathy along with hypothyroidism, renal failure and liver dysfunction. Detection of antinuclear antibodies at a titer of 1/800, anti-SSA, anti-SSB, anti-GP210, anti-microsomial and p-ANCA anti-myeloperoxydase antibodies along with renal, salivary and liver biopsy led to a diagnosis of MPA associated with PBC, Sjogren's syndrome and Hashimoto's thyroiditis.
authors.affiliation: Department of Internal Medicine, La Rabta Hospital, Tunis, Tunisia.
authors.forename: I Ben
authors.initials: IB
authors.lastname: Ghorbel
authors.forename: Nabil
authors.initials: N
authors.lastname: Belfeki
authors.forename: T Ben
authors.initials: TB
authors.lastname: Salem
authors.forename: A
authors.initials: A
authors.lastname: Hamzaoui
authors.forename: M
authors.initials: M
authors.lastname: Khanfir
authors.forename: M
authors.initials: M
authors.lastname: Lamloum
authors.forename: M
authors.initials: M
authors.lastname: Miled
authors.forename: M H
authors.initials: MH
authors.lastname: Houman
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D005260:Female; D050031:Hashimoto Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D055953:Microscopic Polyangiitis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D011237:Predictive Value of Tests; D051437:Renal Insufficiency / Q000209:etiology; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; D007166:Immunosuppressive Agents; D013256:Steroids