title: High expression of flotillin-2 is associated with poor clinical survival in cervical carcinoma.
abstract: OBJECTIVE
  To investigate the expression and clinical significance of flotillin-2 (FLOT2) in cervical cancer (CC).
  
  
  METHODS
  We examined FLOT2 mRNA levels in 10 pairs of cervical cancer and adjacent normal tissues. Immunohistochemistry was performed to analyze FLOT2 protein expression in 115 archived cervical cancer samples. The association between FLOT2 levels, clinicopathologic factors and prognosis was analyzed statistically as well.
  
  
  RESULTS
  The cancer tissues of CC patients had clearly increased expression of FLOT2 at mRNA level as compared to adjacent nontumorous tissues. Survival analysis of CC patients indicated that FLOT2 expression was significantly associated with poor overall and local recurrence-free survival (P = 0.025 and P = 0.028, respectively). Moreover, FLOT2 expression was significantly correlated with clinical stage, tumor differentiation, and lymph nodes metastasis. Multivariate analysis revealed that FLOT2 expression was an independent prognostic factor for overall survival in CC patients.
  
  
  CONCLUSIONS
  FLOT2 may serve as an oncogene in the development of CC, and may serve as a clinicopathologic biomarker for prognosis in CC patients.
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Shenzhen 518000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ji
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Mei
authors.affiliation: Department of Obstetrics and Gynecology, People's Hospital of Hunan Province Changsha 410005, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, Guangzhou Women and Children Medical Center, Guangzhou Medical University Affiliated Women and Children Medical Center Guangzhou 510120, China.
authors.forename: Zhuanxing
authors.initials: Z
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008565:Membrane Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C106354:flotillins
keywords: Cervical cancer; FLOT2; prognosis