title: Chemical composition and antibacterial activity of the essential oil from Agathis dammara (Lamb.) Rich fresh leaves.
abstract: The essential oil of fresh leaves from Agathis dammara (Lamb.) Rich was extracted using hydro-distillation, and GC-FID and GC-MS were used to analyse the essential oil. Nineteen compounds were identified, among which the major components were limonene (36.81%), β-bisabolene (33.43%) and β-myrcene (25.48%). In the antibacterial test, disc diffusion method and micro-well dilution assay proved that the essential oil had significant antibacterial activities. The inhibition zones against Staphylococcus aureus and Pseudomonas aeruginosa were 23.7 and 23 mm, respectively, which demonstrated that the inhibition effects were greater than positive control (10 μg/disc streptomycin). And the lowest MIC value of the essential oil was found against S. aureus (1.25 mg/mL) and Bacillus subtilis (1.25 mg/mL). This is the first report on the antibacterial activities of A. dammara essential oil.
authors.affiliation: a School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640 , P.R. China.
authors.forename: Zhifen
authors.initials: Z
authors.lastname: Chen
authors.forename: Daohang
authors.initials: D
authors.lastname: He
authors.forename: Jingdan
authors.initials: J
authors.lastname: Deng
authors.forename: Jiaying
authors.initials: J
authors.lastname: Zhu
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Mao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils
keywords: Agathis dammara; GC/MS; antibacterial activity; essential oil