title: Leptin levels and lipoprotein profiles in patients with cholelithiasis.
abstract: OBJECTIVE
  To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis.
  
  
  METHODS
  Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A1c levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A1c, total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1.
  
  
  CONCLUSIONS
  Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, with increased leptin levels being associated with increased Lp(a) and ApoB levels, and decreased ApoA-1 levels, in those with cholelithiasis.
authors.affiliation: Termal Vocational School, Yalova University, Yalova, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Saraç
authors.affiliation: Termal Vocational School, Yalova University, Yalova, Turkey aytacatamer@gmail.com.
authors.forename: Aytaç
authors.initials: A
authors.lastname: Atamer
authors.affiliation: Termal Vocational School, Yalova University, Yalova, Turkey.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Atamer
authors.affiliation: Termal Vocational School, Yalova University, Yalova, Turkey.
authors.forename: Ahmet Selçuk
authors.initials: AS
authors.lastname: Can
authors.affiliation: Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Aslan
authors.initials: A
authors.lastname: Bilici
authors.affiliation: Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Taçyildiz
authors.affiliation: Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Koçyiğit
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Harran University, Urfa, Turkey.
authors.forename: Necati
authors.initials: N
authors.lastname: Yenice
mesh_terms: D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002769:Cholelithiasis / Q000097:blood* / Q000175:diagnosis / Q000473:pathology*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D042882:Gallstones / Q000473:pathology; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001786:Blood Glucose; D008076:Cholesterol, HDL; D020738:Leptin
keywords: Leptin; apolipoprotein A-1; apolipoprotein B; cholelithiasis; lipoprotein(a); lipoproteins