title: [Effect of the chelator Zn-DTPA on the excretion of lead in lead intoxication mice detected with ICP-MS].
abstract: To study the lead excretion effect of the chelator Zn-DTPA on the lead intoxication mice, inductively coupled plasma mass spectrometry (ICP-MS) was applied to detect the lead content of biological samples. The acute lead intoxication mice model was established by injecting lead acetate intraperitoneally with the dose of 1 mg. Zn-DTPA was administered intraperitoneally to mice once daily for five consecutive days 4 h after intoxication. Control group, model group, combination of Zn-DTPA and Ca-DTPA group were evaluated at the same time. The urine was collected every day. The mice were sacrificed in batches in the 2rd, 4th, 6th day. Biological samples including urine, whole blood, femur and brain were prepared and nitrated. Lead concentration was detected by ICP-MS. The result showed that Zn-DTPA could increase lead content in urine markedly and reduce lead content in blood, femur and brain.
authors.forename: Chen
authors.initials: C
authors.lastname: Li
authors.forename: Kai-zhi
authors.initials: KZ
authors.lastname: Lu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Yu-liang
authors.initials: YL
authors.lastname: Zeng
authors.forename: Hong-jun
authors.initials: HJ
authors.lastname: Yin
authors.forename: Xuan-hui
authors.initials: XH
authors.lastname: He
authors.forename: Ying
authors.initials: Y
authors.lastname: Tian
authors.forename: Jun-Xing
authors.initials: JX
authors.lastname: Dong
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D007854:Lead / Q000493:pharmacokinetics* / Q000652:urine; D007855:Lead Poisoning / Q000188:drug therapy*; D013058:Mass Spectrometry; D051379:Mice; D004369:Pentetic Acid / Q000494:pharmacology*
chemical_list: D002614:Chelating Agents; D007854:Lead; D004369:Pentetic Acid