title: Correlation of Primary Tumor FDG Uptake with Clinicopathologic Prognostic Factors in Invasive Ductal Carcinoma of the Breast.
abstract: OBJECTIVE
  The purpose of this study was to investigate the correlation of primary tumor FDG uptake to clinicopathological prognostic factors in invasive ductal carcinoma of the breast.
  
  
  METHODS
  We retrospectively reviewed 136 of 215 female patients with pathologically proven invasive ductal breast cancer from January 2008 to December 2011 who underwent F-18 FDG PET/CT for initial staging and follow-up after curative treatment with analysis of estrogen receptor (ER), progesterone receptor (PR) and human epithelial growth factor receptor 2 (HER2). The maximum standardized uptake value (SUVmax) of the primary breast tumor was measured and compared with hormonal receptor and HER2 overexpression status.
  
  
  RESULTS
  The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: tumor size, histologic grade, TNM stage, negativity of ER, negativity of PR, HER2 overexpression and triple negativity. The recurrent group with non-triple negative cancer had a higher SUVmax compared with the non-recurrent group, though no significant difference in FDG uptake was noted between the recurrence and non-recurrent groups in subjects with triple-negative cancer. Lymph node involvement was the independent risk factor for cancer recurrence in the multivariate analysis.
  
  
  CONCLUSIONS
  In conclusion, high FDG uptake in primary breast tumors is significantly correlated with clinicopathological factors, such as tumor size, histologic grade, TNM stage, negativity of the hormonal receptor, HER2 overexpression and triple negativity. Therefore, FDG PET/CT is a helpful prognostic tool to direct the further management of patients with breast cancer.
authors.affiliation: Department of Nuclear Medicine, Keimyung University, School of Medicine, Daegu, Republic of Korea.
authors.forename: I
authors.initials: I
authors.lastname: Jo
authors.affiliation: Department of Nuclear Medicine, Bundang Jesaeng General Hospital, Seohyeon-dong 255-2, Seongnam, Republic of Korea.
authors.forename: Seok Kil
authors.initials: SK
authors.lastname: Zeon
authors.affiliation: Department of Nuclear Medicine, Keimyung University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Nuclear Medicine, Keimyung University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Kim
authors.affiliation: Department of Surgery, Keimyung University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Kang
authors.affiliation: Department of Pathology, Keimyung University, School of Medicine, Daegu, Republic of Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kwon
authors.affiliation: Department of Anesthesiology and Pain Medicine, Dongguk University, School of Medicine, Gyeongju, Republic of Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Kim
keywords: Breast cancer; F-18 FDG; Invasive ductal carcinoma; PET/CT; Triple negative