title: Potential treatments for genetic hearing loss in humans: current conundrums.
abstract: Genetic defects are a major cause of hearing loss in newborns. Consequently, hearing loss has a profound negative impact on human daily living. Numerous causative genes for genetic hearing loss have been identified. However, presently, there are no truly curative treatments for this condition. There have been several recent reports on successful treatments in mice using embryonic gene therapy, neonatal gene therapy and neonatal antisense oligonucleotide therapy. Herein, we describe state-of-the-art research on genetic hearing loss treatment through gene therapy and discuss the obstacles to overcome in curative treatments of genetic hearing loss in humans.
authors.affiliation: Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Minoda
authors.affiliation: Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miwa
authors.affiliation: Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ise
authors.affiliation: Departments of Otolaryngology-Head and Neck Surgery, Kumamoto University, Graduate School of Medicine, Kumamoto City, Kumamoto, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000818:Animals; D007758:Ear, Inner / Q000033:anatomy & histology / Q000254:growth & development; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000628:therapy*; D015316:Genetic Therapy; D034381:Hearing Loss / Q000235:genetics / Q000628:therapy*; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*
chemical_list: D016376:Oligonucleotides, Antisense