title: [Multi-organ failure after massive Levothyroxine ingestion: case report].
abstract: Levothyroxine is the drug of choice prescribed worldwide for the treatment of Hypothyroidism. The exact daily dosage, mode of consumption and refractoriness to therapy are still subject of discussion. The intoxication with levothyroxine is rare and with severe complications in adults; on the contrary, high prevalence and benign course is observed in pediatric age. We report the case of a 56 year-old woman, presented to the emergency department after intentional ingestion of massive levothyroxine overdose , with acute renal failure, severe disturbances of cardiovascular and central nervous system, that required intensive care support. In absence of a specific treatment, plasmapheresis has been used with good results, despite important clinical complications. In fact the clinical applications of plasmapheresis are rapidly increasing in number and scope: the plasmapheresis appears to be a very important tool for the treatment of acute and severe forms of thyrotoxicosis due to l-thyroxine intoxication.
authors.forename: A
authors.initials: A
authors.lastname: Mudoni
authors.forename: F
authors.initials: F
authors.lastname: Caccetta
authors.forename: M
authors.initials: M
authors.lastname: Caroppo
authors.forename: F
authors.initials: F
authors.lastname: Musio
authors.forename: A
authors.initials: A
authors.lastname: Accogli
authors.forename: M D
authors.initials: MD
authors.lastname: Zacheo
authors.forename: M D
authors.initials: MD
authors.lastname: Burzo
authors.forename: V
authors.initials: V
authors.lastname: Nuzzo
mesh_terms: D062787:Drug Overdose / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000628:therapy; D009846:Oliguria / Q000209:etiology / Q000628:therapy; D013974:Thyroxine / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D013974:Thyroxine