title: CLE peptides regulate lateral root development in response to nitrogen nutritional status of plants.
abstract: CLE (CLAVATA3/embryo surrounding region (ESR)) peptides control meristem functions in plants. Our recent study highlights the critical role of a peptide-receptor signaling module composed of nitrogen (N)-responsive CLE peptides and the CLAVATA1 (CLV1) leucine-rich repeat receptor-like kinase in controlling lateral root development in Arabidopsis thaliana. CLE1, -3, -4 and -7 are expressed in root pericycle cells in Arabidopsis roots under N-limited growth conditions. Overexpression of these CLE genes inhibits lateral root emergence from the primary root. The inhibitory action of N-responsive CLE peptides on lateral root development requires the function of CLV1 expressed in phloem companion cells in roots, suggesting that downstream signals are transferred through phloem for systemic regulation of root system architecture. An additional mechanism downstream of CLV1 feedback-regulates transcript levels of N-responsive CLE genes in roots for fine-tuning the signal amplitude.
authors.affiliation: a Department of Biochemistry and Molecular Biology; Michigan State University; East Lansing, MI USA.
authors.forename: Takao
authors.initials: T
authors.lastname: Araya
authors.forename: Nicolaus
authors.initials: N
authors.lastname: von Wirén
authors.forename: Hideki
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D018519:Meristem / Q000254:growth & development / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D009752:Nutritional Status; D010455:Peptides / Q000378:metabolism*; D052585:Phloem / Q000378:metabolism*; D018517:Plant Roots / Q000254:growth & development* / Q000378:metabolism; D030821:Plants, Genetically Modified; D017346:Protein Serine-Threonine Kinases; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C118167:AT2G27250 protein, Arabidopsis; D029681:Arabidopsis Proteins; D010455:Peptides; D020794:Receptor Protein-Tyrosine Kinases; C118166:CLV1 protein, Arabidopsis; D017346:Protein Serine-Threonine Kinases; D009584:Nitrogen
keywords: Arabidopsis thaliana; CLE peptide; leucine-rich repeat receptor-like kinase; morphology; nitrogen; root; signaling