title: The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma.
authors.affiliation: Respiratory Clinical Trials Ltd, London, United Kingdom. Electronic address: Brian.Leaker@qasmc.com.
authors.forename: Brian R
authors.initials: BR
authors.lastname: Leaker
authors.affiliation: Respiratory Clinical Trials Ltd, London, United Kingdom.
authors.forename: Brian
authors.initials: B
authors.lastname: O'Connor
authors.affiliation: Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, University of Manchester, Manchester, United Kingdom.
authors.forename: Dave
authors.initials: D
authors.lastname: Singh
authors.affiliation: National Heart & Lung Institute, Imperial College, London, United Kingdom.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barnes
mesh_terms: D000249:Adenosine Monophosphate / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects*; D004311:Double-Blind Method; D015870:Gene Expression; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D011965:Receptors, Glucocorticoid / Q000819:agonists* / Q000235:genetics / Q000276:immunology; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D018927:Anti-Asthmatic Agents; C581038:GW870086X; D011965:Receptors, Glucocorticoid; D013256:Steroids; D015675:Osteocalcin; D000249:Adenosine Monophosphate; D006854:Hydrocortisone