title: Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.
abstract: Parkinson's disease (PD) and schizophrenia (SCZ) are frequent central nervous disorders that have unclear etiologies but that show similarities in their pathogenesis. Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated with either disease. We used the ligase detection reaction to genotype a case-control cohort of Han Chinese patients with PD or SCZ and healthy controls at the HNMT-Thr105Ile locus. The Ile allele was associated with reduced risk of PD (OR 0.516, 95% CI 0.318 to 0.838, p = 0.007) and of SCZ (OR 0.499, 95% CI 0.288 to 0.865, p = 0.011). Genotype frequencies and minor allele frequencies were similar between patients and controls when we compared males with females or early-onset patients with late-onset ones. Genotype and allele frequencies were not significantly different between PD patients with dyskinesia and PD patients without dyskinesia. Our results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against PD and SCZ in Han Chinese.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China.
authors.forename: Xinglong
authors.initials: X
authors.lastname: Yang
authors.affiliation: College of Basic and Forensic Medicine, Sichuan University, Chengdu, Sichuan Province, 610041, PR China; Department of Psychiatry, Jining Medical College, Jining, Shandong Province, 272051, PR China.
authors.forename: Chuanxin
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Psychiatry, Jining Mental Hospital, Jining, Shandong Province, 272051, PR China.
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510630, PR China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Han
authors.affiliation: Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, 410011, PR China.
authors.forename: Xiuyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Neurology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, 510080, PR China.
authors.forename: Zhoulin
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006632:Histamine / Q000235:genetics; D006637:Histamine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D013912:Threonine / Q000235:genetics
chemical_list: D007532:Isoleucine; D013912:Threonine; D006632:Histamine; D006637:Histamine N-Methyltransferase