title: Elaboration of copper-oxygen mediated C-H activation chemistry in consideration of future fuel and feedstock generation.
abstract: To contribute solutions to current energy concerns, improvements in the efficiency of dioxygen mediated C-H bond cleavage chemistry, for example, selective oxidation of methane to methanol, could minimize losses in natural gas usage or produce feedstocks for fuels. Oxidative C-H activation is also a component of polysaccharide degradation, potentially affording alternative biofuels from abundant biomass. Thus, an understanding of active-site chemistry in copper monooxygenases, those activating strong C-H bonds is briefly reviewed. Then, recent advances in the synthesis-generation and study of various copper-oxygen intermediates are highlighted. Of special interest are cupric-superoxide, Cu-hydroperoxo and Cu-oxy complexes. Such investigations can contribute to an enhanced future application of C-H oxidation or oxygenation processes using air, as concerning societal energy goals.
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA.
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: karlin@jhu.edu.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Karlin
mesh_terms: D002244:Carbon / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004798:Enzymes / Q000378:metabolism; D006859:Hydrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D059205:Renewable Energy
chemical_list: D004798:Enzymes; D002244:Carbon; D003300:Copper; D006859:Hydrogen; D010100:Oxygen