title: The association between follicular size at the time of spontaneous rupture and pregnancy rates in clomiphene citrate treated PCOS patients in coit cycles.
abstract: OBJECTIVE
  To investigate the follicular size at spontaneous rupture on pregnancy rate in patients with polycystic ovary syndrome (PCOS) undergoing clomiphene citrate (CC) ovulation.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  One hundred and four women with ovulatory cycles after use of CC followed by ultrasound to determine the follicle size at the time of rupture, which was subsequently correlated with the occurrence of pregnancy or not in coit cycles.
  
  
  RESULTS
  In the group of follicular rupture at a mean diameter ≤25 mm (n = 54), pregnancy rate was 35.1% and when follicular rupture occurred at a mean diameter >25 mm (n = 50), it was 34% (p > 0.05). When different diameters at follicular rupture were randomly correlated with the pregnancy rate, there was no significant difference.
  
  
  CONCLUSIONS
  Our data suggest that the occurrence of pregnancy after ovulation induction with CC in women with PCOS is not associated with follicle size at the time of rupture.
authors.affiliation: GENESIS - Center for Assistance in Human Reproduction , Brasília , Brazil .
authors.forename: Carlos
authors.initials: C
authors.lastname: Portocarrero-Sanchez
authors.forename: David Barreira
authors.initials: DB
authors.lastname: Gomes-Sobrinho
authors.forename: Hitomi Miura
authors.initials: HM
authors.lastname: Nakagawa
authors.forename: Adelino Amaral
authors.initials: AA
authors.lastname: Silva
authors.forename: Bruno Ramalho de
authors.initials: BR
authors.lastname: Carvalho
authors.forename: Nathália Travassos
authors.initials: NT
authors.lastname: Sarkis
authors.forename: José Carlos
authors.initials: JC
authors.lastname: Peraçoli
authors.forename: Maria Teresinha de Oliveira
authors.initials: MT
authors.lastname: Cardoso
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D009929:Organ Size; D006080:Ovarian Follicle / Q000000981:diagnostic imaging* / Q000254:growth & development; D010060:Ovulation; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D014463:Ultrasonography
chemical_list: D004965:Estrogen Antagonists; D002996:Clomiphene
keywords: Anovulatory infertility; PCOS; clomiphene citrate; follicular size; pregnancy rate