title: Influence of Dexmedetomidine on the Tourniquet Related Responses in Hypertension Patients Receiving Unilateral Knee Arthroplasty under General Anesthesia.
abstract: This study aimed to investigate the influence of dexmedetomidine (DEX) on the tourniquet related responses in hypertension patients receiving unilateral knee arthroplasty (UKA) under general anesthesia. Results showed that the incidence of tourniquet induced hypertension (TIH), hemodynamics, MAC and EtSEV in DEX group were significantly lower than those in control group, regardless of hypertension. However, significant differences in TIH, hemodynamics, minimum alveolar concentration (MAC) and end-tidal sevoflurane (EtSEV) were not observed between hypertension patients and non-hypertension patients in both control group and DEX group. Moreover, oxygen index (OI) and respiratory index (RI) remained unchanged after deflation and DEX failed to affect OI and RI within 30 min after deflation, regardless of hypertension. Taken together, DEX may significantly improve the hemodynamics, which is independent of pre-existing hypertension.
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Shuguang Hospital, Traditional Chinese Medicine University, Shanghai, China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Qilu Hospital of Tsingdao City, Tsingdao, Shandong, China.
authors.forename: Yi-Jie
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Dong-Yu
authors.initials: DY
authors.lastname: Zheng
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Mou-Li
authors.initials: ML
authors.lastname: Tian
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000768:Anesthesia, General / Q000379:methods*; D000959:Antihypertensive Agents; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects; D020927:Dexmedetomidine / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000150:complications*; D015994:Incidence; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D010100:Oxygen / Q000737:chemistry; D012129:Respiratory Function Tests; D056152:Respiratory Rate; D000077149:Sevoflurane; D013997:Time Factors; D014111:Tourniquets
chemical_list: D018712:Analgesics, Non-Narcotic; D000959:Antihypertensive Agents; D008738:Methyl Ethers; D000077149:Sevoflurane; D020927:Dexmedetomidine; D010100:Oxygen
keywords: dexmedetomidine; hemodynamic; hypertension; lung function; unilateral knee arthroplasty