title: Simultaneous photoacoustic and optically mediated ultrasound microscopy: an in vivo study.
abstract: We propose the use of thermoelastic (TE) excitation of an ultrasonic (US) detector by backscattered laser radiation as a means of upgrading a single-modality photoacoustic (PA) microscope to dual-modality PA/US imaging at minimal cost. The upgraded scanning head of our dual-modality microscope consists of a fiber bundle with 14 output arms and a 32MHz polyvinylidene difluoride (PVDF) detector with a 34 MHz bandwidth (-6 dB level), 12.7 mm focal length, and a 0.25 numerical aperture. A single optical pulse delivered through the fiber bundle to the biotissue being investigated, in combination with a metalized surface on the PVDF detector allows us to obtain both PA and US A-scans. To demonstrate the in vivo capabilities of the proposed method we present the results of bimodal imaging of the brain of a newborn rat, a mouse tail and a mouse tumor.
authors.affiliation: Institute of Applied Physics RAS, 46 Ulyanov Street, Nizhniy Novgorod, Russia.
authors.forename: Pavel
authors.initials: P
authors.lastname: Subochev
authors.affiliation: Institute of Applied Physics RAS, 46 Ulyanov Street, Nizhniy Novgorod, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Orlova
authors.affiliation: Lobachevsky State University of Nizhny Novgorod, 19 Gagarin Avenue, Nizhniy Novgorod, Russia ; Nizhny Novgorod State Medical Academy, Nizhniy Novgorod, Russia.
authors.forename: Marina
authors.initials: M
authors.lastname: Shirmanova
authors.affiliation: Institute of Applied Physics RAS, 46 Ulyanov Street, Nizhniy Novgorod, Russia.
authors.forename: Anna
authors.initials: A
authors.lastname: Postnikova
authors.affiliation: Institute of Applied Physics RAS, 46 Ulyanov Street, Nizhniy Novgorod, Russia.
authors.forename: Ilya
authors.initials: I
authors.lastname: Turchin
keywords: (170.5120) Photoacoustic imaging; (170.7180) Ultrasound diagnostics