title: A valve-less microfluidic peristaltic pumping method.
abstract: We demonstrate a valve-less microfluidic peristaltic pumping method which enables the delivery of continuous nanoliter-scale flow with high precision. The fluid is driven by squeezing the microchannels embedded in a poly(dimethylsiloxane) device with rolling cams or bearings. We achieve continuous and uniform flow with velocity range from 1 to 500 nl/s, with outflow volume error within 3 nl. The devices show enhanced backpressure resistance up to 340 kPa. This method also shows great flexibility. By altering the channels' layout, emulsions and plugs can be generated easily. These low-cost and easy-to-fabricate micro-pumps offer novel approaches for liquid actuation in various microfluidic applications.
authors.affiliation: Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Xiannian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Zitian
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Biodynamic Optical Imaging Center (BIOPIC), and College of Engineering, Peking University , Beijing 100871, China.
authors.forename: Yanyi
authors.identifier: 0000-0002-7297-1266
authors.initials: Y
authors.lastname: Huang