title: VHR/DUSP3 phosphatase: structure, function and regulation.
abstract: Vaccinia H1-related (VHR) phosphatase, also known as dual-specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases. VHR has a preference for phospho-tyrosine substrates, and has important roles in cellular signaling ranging from cell-cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR/DUSP3 has been implicated in several human cancers, where its tumor-suppressing and -promoting properties have been described. We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
authors.forename: Karolina
authors.initials: K
authors.lastname: Pavic
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
authors.forename: Guangyou
authors.initials: G
authors.lastname: Duan
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
authors.forename: Maja
authors.initials: M
authors.lastname: Köhn
mesh_terms: D000818:Animals; D054640:Dual Specificity Phosphatase 3 / Q000378:metabolism*; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D020928:Mitogen-Activated Protein Kinases; D054640:Dual Specificity Phosphatase 3
keywords: DUSP13B; DUSP26; DUSP27; MAPK signaling; VHR/DUSP3 inhibitors; Vaccinia H1-related phosphatase; cancer; cell-cycle progression; dual specificity phosphatases; protein phosphatases