title: Influence of ibuprofen on phospholipid membranes.
abstract: A basic understanding of biological membranes is of paramount importance as these membranes comprise the very building blocks of life itself. Cells depend in their function on a range of properties of the membrane, which are important for the stability and function of the cell, information and nutrient transport, waste disposal, and finally the admission of drugs into the cell and also the deflection of bacteria and viruses. We have investigated the influence of ibuprofen on the structure and dynamics of L-α-phosphatidylcholine (SoyPC) membranes by means of grazing incidence small-angle neutron scattering, neutron reflectometry, and grazing incidence neutron spin echo spectroscopy. From the results of these experiments, we were able to determine that ibuprofen induces a two-step structuring behavior in the SoyPC films, where the structure evolves from the purely lamellar phase for pure SoyPC over a superposition of two hexagonal phases to a purely hexagonal phase at high concentrations. A relaxation, which is visible when no ibuprofen is present in the membrane, vanishes upon addition of ibuprofen. This we attribute to a stiffening of the membrane. This behavior may be instrumental in explaining the toxic behavior of ibuprofen in long-term application.
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Jaksch
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Frederik
authors.initials: F
authors.lastname: Lipfert
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Koutsioubas
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Mattauch
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Olaf
authors.initials: O
authors.lastname: Holderer
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Oxana
authors.initials: O
authors.lastname: Ivanova
authors.affiliation: Forschungszentrum Jülich GmbH, JCNS at Heinz Maier-Leibnitz Zentrum, Lichtenbergstraße 1, D-85747 Garching, Germany.
authors.forename: Henrich
authors.initials: H
authors.lastname: Frielinghaus
authors.affiliation: Ludwig-Maximilians-Universität, Department für Physik und CeNS, Geschwister-Scholl-Platz 1, D-80539 München, Germany.
authors.forename: Samira
authors.initials: S
authors.lastname: Hertrich
authors.affiliation: Ludwig-Maximilians-Universität, Department für Physik und CeNS, Geschwister-Scholl-Platz 1, D-80539 München, Germany.
authors.forename: Stefan F
authors.initials: SF
authors.lastname: Fischer
authors.affiliation: Ludwig-Maximilians-Universität, Department für Physik und CeNS, Geschwister-Scholl-Platz 1, D-80539 München, Germany.
authors.forename: Bert
authors.initials: B
authors.lastname: Nickel
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000633:toxicity; D004548:Elasticity; D007052:Ibuprofen / Q000737:chemistry* / Q000633:toxicity; D008051:Lipid Bilayers / Q000737:chemistry*; D033363:Neutron Diffraction; D010713:Phosphatidylcholines / Q000737:chemistry*; D053838:Scattering, Small Angle; D013057:Spectrum Analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D007052:Ibuprofen