title: CIDRE: an illumination-correction method for optical microscopy.
abstract: Uneven illumination affects every image acquired by a microscope. It is often overlooked, but it can introduce considerable bias to image measurements. The most reliable correction methods require special reference images, and retrospective alternatives do not fully model the correction process. Our approach overcomes these issues for most optical microscopy applications without the need for reference images.
authors.affiliation: Scientific Center for Optical and Electron Microscopy, ETH Zürich, Zurich, Switzerland.
authors.forename: Kevin
authors.identifier: 000000026163191X
authors.initials: K
authors.lastname: Smith
authors.affiliation: Computer Vision Laboratory, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Advanced Research Center on Electronic Systems, University of Bologna, Bologna, Italy.
authors.forename: Filippo
authors.identifier: 0000000203717782
authors.initials: F
authors.lastname: Piccinini
authors.affiliation: Scientific Center for Optical and Electron Microscopy, ETH Zürich, Zurich, Switzerland.
authors.forename: Gabor
authors.initials: G
authors.lastname: Csucs
authors.affiliation: Scientific Center for Optical and Electron Microscopy, ETH Zürich, Zurich, Switzerland.
authors.forename: Csaba
authors.initials: C
authors.lastname: Balazs
authors.affiliation: 1] Advanced Research Center on Electronic Systems, University of Bologna, Bologna, Italy. [2] Department of Computer Science and Engineering, University of Bologna, Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bevilacqua
authors.affiliation: 1] Institute of Biochemistry, ETH Zürich, Zurich, Switzerland. [2] Synthetic and System Biology Unit, Biological Research Center, Szeged, Hungary. [3] Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
authors.forename: Peter
authors.initials: P
authors.lastname: Horvath
mesh_terms: D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008027:Light; D008853:Microscopy / Q000379:methods*; D012984:Software