title: Familial risks and estrogen receptor-positive breast cancer in Hong Kong Chinese women.
abstract: OBJECTIVE
  The role of family history to the risk of breast cancer was analyzed by incorporating menopausal status in Hong Kong Chinese women, with a particular respect to the estrogen receptor-positive (ER+) type.
  
  
  METHODS
  Seven hundred and forty seven breast cancer incident cases and 781 hospital controls who had completed information on family cancer history in first-degree relatives (nature father, mother, and siblings) were recruited. Odds ratio for breast cancer were calculated by unconditional multiple logistic regression, stratified by menopausal status (a surrogate of endogenous female sex hormone level and age) and type of relative affected with the disease. Further subgroup analysis by tumor type according to ER status was investigated.
  
  
  RESULTS
  Altogether 52 (6.96%) breast cancer cases and 23 (2.95%) controls was found that the patients' one or more first-degree relatives had a history of breast cancer, showing an adjusted odds ratio (OR) of 2.41 (95%CI: 1.45-4.02). An excess risk of breast cancer was restricted to the ER+ tumor (OR = 2.43, 95% CI: 1.38-4.28), with a relatively higher risk associated with an affected mother (OR = 3.97, 95%CI: 1.46-10.79) than an affected sister (OR = 2.06, 95%CI: 1.07-3.97), while the relative risk was more prominent in the subgroup of pre-menopausal women. Compared with the breast cancer overall, the familial risks to the ER+ tumor increased progressively with the number of affected first-degree relatives.
  
  
  CONCLUSIONS
  This study provides new insights on a relationship between family breast cancer history, menopausal status, and the ER+ breast cancer. A separate risk prediction model for ER+ tumor in Asian population is desired.
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Lap Ah
authors.initials: LA
authors.lastname: Tse
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Mengjie
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Surgery, North District Hospital, Hong Kong SAR, China.
authors.forename: Wing-cheong
authors.initials: WC
authors.lastname: Chan
authors.affiliation: Department of Oncology, Princess Margaret Hospital, Hong Kong SAR, China.
authors.forename: Chi-hei
authors.initials: CH
authors.lastname: Kwok
authors.affiliation: Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
authors.forename: Siu-lan
authors.initials: SL
authors.lastname: Leung
authors.affiliation: Department of Pathology, North District Hospital, Hong Kong SAR, China.
authors.forename: Cherry
authors.initials: C
authors.lastname: Wu
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Ignatius Tak-sun
authors.initials: IT
authors.lastname: Yu
authors.affiliation: Department of Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
authors.forename: Wai-cho
authors.initials: WC
authors.lastname: Yu
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Lao
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Wang
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Carmen Ka-man
authors.initials: CK
authors.lastname: Wong
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Priscilla Ming-yi
authors.initials: PM
authors.lastname: Lee
authors.affiliation: JC School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.affiliation: Genetic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, United States of America.
authors.forename: Xiaohong Rose
authors.initials: XR
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006723:Hong Kong; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D011960:Receptors, Estrogen