title: Effects of female increased body mass index on in vitro fertilization cycles outcome.
abstract: BACKGROUND
  As being overweight can impair female spontaneous fertility or after assisted reproductive technology (ART) cycles, the aim of this study was to compare in vitro fertilization (IVF) outcome according to women's body mass index (BMI).
  
  
  METHODS
  Retrospective study conducted from 2006 to 2009 in the IVF unit of Nantes University Hospital, France. 582 patients undergoing standard infertility workup and controlled ovarian stimulation were categorized according to BMI into two groups: group 1: normal weight (20-24.9 kg/m(2); n=409) and group 2: overweight and obese (≥25 kg/m(2); n=149). Basal hormonal status, smoking habitus, infertility duration, IVF cycle parameters and outcome were recorded.
  
  
  RESULTS
  Basal LH, FSH and estradiol levels were higher in group 1 than group 2, but ovarian reserve markers were comparable across the two BMI groups. Higher doses of gonadotropins were required in group 2 to obtain equivalent ovarian response than in group 1. No difference was observed on ovarian response and embryonic parameters. Cycle outcome were not significantly different between both groups, but we found a strong trend towards increasing transfer cancellation and miscarriage rates in group 2.
  
  
  CONCLUSIONS
  Although overweight and obesity do not compromise ovarian stimulation results whenever adaptation of recombinant FSH doses is made, our data suggest an increased risk of cancellation transfer and miscarriage rate, leading to poorer IVF outcome.
authors.affiliation: Hormonology and Biochemistry Laboratory, CHU Nantes, France. Electronic address: helene.caillon@chu-nantes.fr.
authors.forename: Hélène
authors.initials: H
authors.lastname: Caillon
authors.affiliation: Department of Human Reproduction, CHU Nantes, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fréour
authors.affiliation: Hormonology and Biochemistry Laboratory, CHU Nantes, France.
authors.forename: Kalyane
authors.initials: K
authors.lastname: Bach-Ngohou
authors.affiliation: Department of Human Reproduction, CHU Nantes, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Colombel
authors.affiliation: Hormonology and Biochemistry Laboratory, CHU Nantes, France.
authors.forename: Marc G
authors.initials: MG
authors.lastname: Denis
authors.affiliation: Department of Human Reproduction, CHU Nantes, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Barrière
authors.affiliation: Hormonology and Biochemistry Laboratory, CHU Nantes, France.
authors.forename: Damien
authors.initials: D
authors.lastname: Masson
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005602:France / Q000453:epidemiology; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D004958:Estradiol; D007986:Luteinizing Hormone
keywords: Assisted reproductive technology; Body mass index; In vitro fertilization; Obesity; Ovarian stimulation