title: An aryl-thioether substituted nitrobenzothiadiazole probe for the selective detection of cysteine and homocysteine.
abstract: An aryl-thioether substituted nitrobenzothiadiazole probe was synthesized and employed to detect cysteine and homocysteine selectively in living cells. Interestingly, both cysteine (Cys) and homocysteine (Hcy) promote an enhancement of the fluorescence intensity of the probe at pH 7.4 while only Cys gives rise to this enhancement under weakly acidic conditions (pH 6.0).
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea. jyoon@ewha.ac.kr.
authors.forename: Dayoung
authors.initials: D
authors.lastname: Lee
authors.forename: Gyoungmi
authors.initials: G
authors.lastname: Kim
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Juyoung
authors.initials: J
authors.lastname: Yoon
mesh_terms: D003545:Cysteine / Q000032:analysis* / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006710:Homocysteine / Q000032:analysis* / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013440:Sulfides / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D013440:Sulfides; D006710:Homocysteine; D003545:Cysteine