title: The rs3771863 single nucleotide polymorphism of the TACR1 gene is associated to a lower risk of sicca syndrome in fibromyalgia patients.
abstract: OBJECTIVE
  Fibromyalgia (FM) has been associated with affective spectrum disorders and other chronic pain disorders, which tend to co-occur in individuals and co-aggregate among families. The objective of our study was to investigate the genetic risk factors associated with the presence of related symptoms and with disease severity in subjects affected with FM.
  
  
  METHODS
  Two independent cohorts of subjects diagnosed with FM according to the 1990 ACR criteria were studied. A genetic array composed of 320 single nucleotide polymorphisms (SNPs) was analysed in a discovery cohort comprised by 564 patients, and the most suggestive variants were genotyped in a replication cohort, comprised by 397 subjects. The associated conditions and related symptoms analysed were: the presence of depression, sleep disorders, headache, myofascial syndrome, irritable bowel syndrome, chronic fatigue syndrome, vertiginous syndrome, chronic cystitis, and sicca syndrome. FM severity was assessed by the Fibromyalgia Impact Questionnaire and the Hospital Anxiety and Depression Scale. Analyses were adjusted by elapsed time from pain onset, and a meta-analysis was performed to pool the results.
  
  
  RESULTS
  Minor allele of the rs3771863 SNP from the TACR1 gene showed a significant association with a lower risk of sicca syndrome (pooled and adjusted OR 0.56, [95%CI 0.42-0.76], p=0.00022).
  
  
  CONCLUSIONS
  Our findings indicate a role of the TACR1 gene in the development of sicca syndrome in subjects affected with FM.
authors.affiliation: Rheumatology Department and Health Research Institute (IdISsC), Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Rodriguez-Rodriguez
authors.affiliation: Rheumatology Department and Health Research Institute (IdISsC), Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Jose
authors.initials: J
authors.lastname: Ramón Lamas
authors.affiliation: Rheumatology Department and Health Research Institute (IdISsC), Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Lydia
authors.initials: L
authors.lastname: Abásolo
authors.affiliation: Rheumatology Department and Health Research Institute (IdISsC), Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Baena
authors.affiliation: Progenika Biopharma SA, Derio, Spain.
authors.forename: Estíbaliz
authors.initials: E
authors.lastname: Olano-Martin
authors.affiliation: Fibromyalgia Specialised Unit, Servicio de Reumatologia, ICEMEQ, Hospital Clínic de Barcelona, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Collado
authors.affiliation: Rheumatology Unit, Instituto Provincial de Rehabilitación, Hospital Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Rivera
authors.affiliation: Rheumatology Department and Health Research Institute (IdISsC), Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Fernández-Gutiérrez
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005356:Fibromyalgia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D018040:Receptors, Neurokinin-1 / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D018040:Receptors, Neurokinin-1