title: Modulation of temporal summation threshold of the nociceptive withdrawal reflex by transcutaneous spinal direct current stimulation in humans.
abstract: OBJECTIVE
  Transcutaneous spinal direct current stimulation (tsDCS) modulates spinal cord pain pathways. The study is aimed to clarify the neurophysiology of the tsDCS-induced modulation of the spinal cord pain processing by evaluating the effect of the tsDCS on temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR).
  
  
  METHODS
  In a randomized, double-blind, crossover study the effects of anodal, cathodal and sham tsDCS (2 mA, 15 min) applied on the skin overlying the thoracic spinal cord were investigated in 10 healthy subjects.
  
  
  RESULTS
  Anodal tsDCS induced a long-lasting (up to 60 min) increase in TST of the NWR as well as a parallel decrease in related psychophysical temporal summation of pain, while cathodal and sham tsDCS resulted ineffective.
  
  
  CONCLUSIONS
  Anodal tsDCS represents a non-invasive tool able to induce an early and long-lasting depression of the transitory facilitation of the wide dynamic range neurons activity at the basis of both the temporal summation of the NWR and the related temporal summation of pain sensation.
  
  
  CONCLUSIONS
  The modulation of the temporal processing of nociceptive stimuli could be effective in treating clinical pain conditions in which pain is generated by spinal cord structures.
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy. Electronic address: arm.perrotta@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Perrotta
authors.affiliation: Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy; Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.affiliation: Unit of Neurorehabilitation, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, ICOT, Latina, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Anastasio
authors.affiliation: Unit of Neurorehabilitation, Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, ICOT, Latina, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Serrao
authors.affiliation: Department of Public Health and Neuroscience, University of Pavia, Pavia, Italy; Headache Science Center, IRCCS National Neurological Institute C. Mondino Foundation, Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Sandrini
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pierelli
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D059408:Pain Management; D010147:Pain Measurement / Q000379:methods* / Q000523:psychology; D011930:Reaction Time / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods* / Q000523:psychology; D055815:Young Adult
keywords: Nociceptive withdrawal reflex; Temporal summation; Transcutaneous spinal direct current stimulation; Wide dynamic range neurons