title: [The effect of 18β-glycyrrhetinic acid on tight junctions of the nasal mucosa epithelial cells in rat models with allergic rhinitis].
abstract: OBJECTIVE
  To observe 18β-glycyrrhetinic acid (GA) impact on ultrastructure of tight junctions (TJs) of nasal mucosa epithelial cells in rats models of allergic rhinitis (AR).
  
  
  METHODS
  Ninety-six Wistar rats were randomly divided into control group, model group, loratadine group, and 18β-glycyrrhetinic acid group, and each group had 24 rats. Ovalbumin was used to establish a rat AR model. The behavioral changes and the tight junctions of nasal epithelial were observed and compared in different groups after 2,4,6 and 10 weeks intervention.
  
  
  RESULTS
  The length of TJs in allergic rhinitis model became shorter, electron-high-density plasma membrane became thicker, number of the integration loci reduced and gap of TJs widened or even ruptured. With the consistent effect of allergens,the changes of TJs in the model group aggravated gradually,and the changes of ultrastructure of TJs in 18β-glycyrrhetinic acid group was relieved apparently compared to model group and even were close to the control model with time.
  
  
  CONCLUSIONS
  18β-glycyrrhetinic acid can recover the ultrastructure of the tight junctions of AR rat nasal epithelial cells.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Gui
authors.forename: Youhu
authors.initials: Y
authors.lastname: Wang
authors.forename: Kehu
authors.initials: K
authors.lastname: Xi
authors.forename: Xiaowan
authors.initials: X
authors.lastname: Chen
authors.forename: Fuhong
authors.initials: F
authors.lastname: Zhang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Hong
authors.forename: Xiangyi
authors.initials: X
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Ming
authors.initials: M
authors.lastname: Dong
authors.forename: Guijun
authors.initials: G
authors.lastname: Yang
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002452:Cell Count; D004847:Epithelial Cells / Q000648:ultrastructure; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009297:Nasal Mucosa / Q000166:cytology*; D010047:Ovalbumin; D051381:Rats; D017208:Rats, Wistar; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D019108:Tight Junctions / Q000187:drug effects*
chemical_list: C119129:18alpha-glycyrrhetinic acid; D010047:Ovalbumin; D006034:Glycyrrhetinic Acid