title: [Determination of 12 bisphenol substances in functional foods by QuEChERS and high performance liquid chromatography-tandem mass spectrometry].
abstract: A method based on high performance liquid chromatography-tandem mass spectrom- etry (HPLC-MS/MS) for the simultaneous determination of 12 bisphenol substances in functional foods (powder, tablet, capsule) was presented. The samples were extracted by acetonitrile containing 1% (v/v) acetic acid followed by further cleaned up using matrix solid-phase disper- sion to remove matrix interferences. The separation of the 12 bisphenol substances was performed on a Thermo Aquasil C18 column (150 mm x 4.6 mm, 3.0 μm), and determined in the positive and negative MRM modes by MS/MS using matrix-matched external standard method. The results demonstrated that the calibration curves were of good linearity with the correlation coefficients greater than 0.99. The limits of detection (LODs, S/N > 3) were in the range of 0.1-0.5 μg/kg and the limits of quantitation (LOQs, S/N > 10) were 0.4-1.7 μg/kg. The recoveries of the 12 bisphenol substances spiked at three levels (2.0, 5.0 and 10.0 μg/kg) in matrix ranged from 60.5% to 116.3% with the relative standard deviations (RSDs) of 6.8% to 11.2%. The established method is simple, time-saving and sensitive. It can meet the requirements for current regulations while achieving qualitative and quantitative determination of the 12 bisphenol substances in functional foods.
authors.forename: Mengjie
authors.initials: M
authors.lastname: Gao
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Sheng
authors.forename: Shanzhen
authors.initials: S
authors.lastname: Zhao
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Deng
authors.forename: Dehua
authors.initials: D
authors.lastname: Guo
authors.forename: Zhuoping
authors.initials: Z
authors.lastname: Ding
authors.forename: Guomin
authors.initials: G
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D055951:Functional Food / Q000032:analysis*; D057230:Limit of Detection; D010636:Phenols / Q000032:analysis*; D053719:Tandem Mass Spectrometry; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds