title: miR2GO: comparative functional analysis for microRNAs.
abstract: miR2GO is a web-based platform for comparative analyses of human miRNA functions. It includes two programs: miRmut2GO and miRpair2GO. miRmut2GO implements a knowledge-based method to assess the functional effects of genetic and somatic mutations in microRNA seed regions. The functional effects of a mutation are analysed by semantic comparison of enriched gene ontology (GO) annotations of the target gene sets for the wild-type and mutated alleles. miRpair2GO compares the functions of two different miRNAs based on the enriched functional annotations of their target gene sets.
  
  
  METHODS
  The miR2GO web server is available at http://compbio.uthsc.edu/miR2GO.
authors.affiliation: Department of Microbiology, Immunology and Biochemistry and Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Anindya
authors.initials: A
authors.lastname: Bhattacharya
authors.affiliation: Department of Microbiology, Immunology and Biochemistry and Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Cui
mesh_terms: D063990:Gene Ontology; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry* / Q000378:metabolism; D058977:Molecular Sequence Annotation; D009154:Mutation; D012984:Software
chemical_list: D035683:MicroRNAs