title: Combined Use of MR Fat Quantification and MR Elastography in Living Liver Donors: Can It Reduce the Need for Preoperative Liver Biopsy?
abstract: OBJECTIVE
  To evaluate the diagnostic performance of magnetic resonance (MR) fat quantification and MR elastography for the assessment of hepatic steatosis and fibrosis in living liver donor candidates.
  
  
  METHODS
  This retrospective study was approved by the institutional review board, and the requirement of informed consent was waived. Donors who underwent MR fat quantification and MR elastography at 1.5 T, followed by liver biopsy, were chronologically grouped into test and validation groups. In the test group (n = 362), MR fat fraction and liver stiffness were compared among donors with normal parenchyma (n = 244), simple steatosis (n = 71), steatosis with inflammatory activity (n = 21), nonalcoholic steatohepatitis (n = 17), and fibrosis (n = 9). Diagnostic performance of the two techniques was assessed by using receiver operating characteristic curve analysis for the detection of substantial steatosis (macrovesicular fat ≥ 10%) or fibrosis (≥F1) and was tested in a validation group (n = 34).
  
  
  RESULTS
  In the test group, donors with steatosis showed significantly higher fat fraction than donors without steatosis (P < .0001), and donors with fibrosis and nonalcoholic steatohepatitis showed significantly higher liver stiffness values than donors without fibrosis (P < .0001). Areas under the curve were 0.93 (cutoff value > 5.8%) for MR fat quantification and 0.85 (cutoff value > 1.94 kPa) for MR elastography. By using those values, the combination of the two techniques could be used to detect substantial steatosis or fibrosis with 100% sensitivity (12 of 12 patients, 95% confidence interval: 73.4%, 100%) and 100% negative predictive value (15 of 15 patients, 95% confidence interval: 78.0%, 100%) in the validation group.
  
  
  CONCLUSIONS
  A combination of MR fat quantification and MR elastography can provide sufficient sensitivity to detect substantial steatosis or fibrosis (≥F1) in liver donor candidates.
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Jeong Hee
authors.initials: JH
authors.lastname: Yoon
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Kwan-Woong
authors.initials: KW
authors.lastname: Lee
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Yi
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Kyung Bun
authors.initials: KB
authors.lastname: Lee
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Joon Koo
authors.initials: JK
authors.lastname: Han
authors.affiliation: From the Departments of Radiology (J.H.Y., J.M.L., J.K.H., B.I.C.), Surgery (K.S.S., K.W.L., N.J.Y.), and Pathology (K.B.L.), Seoul National University Hospital, Seoul, South Korea; and Institute of Radiation Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea (J.M.L., J.K.H., B.I.C.).
authors.forename: Byung Ihn
authors.initials: BI
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000706:statistics & numerical data; D046148:Donor Selection; D054459:Elasticity Imaging Techniques; D005234:Fatty Liver / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D019520:Living Donors; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D012189:Retrospective Studies; D055815:Young Adult