title: Direct C(sp(2) )-C(sp(3) ) Cross-Coupling of Diaryl Zinc Reagents with Benzylic, Primary, Secondary, and Tertiary Alkyl Halides.
abstract: The direct C(sp(2) )-C(sp(3) ) cross-coupling of diaryl zinc reagents with benzylic, primary, secondary, and tertiary alkyl halides proceeded in the absence of coordinating ethereal solvents at ambient temperature without the addition of a catalyst. The C(sp(2) )-C(sp(3) ) cross-coupling showed excellent functional-group tolerance, and products were isolated in high yields, generally without the requirement for purification by chromatography. This process represents an expedient, operationally simple method for the construction of new C(sp(2) )-C(sp(3) ) bonds.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL (UK).
authors.forename: Jay J
authors.initials: JJ
authors.lastname: Dunsford
authors.forename: Ewan R
authors.initials: ER
authors.lastname: Clark
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Ingleson
keywords: alkyl halides; cross-coupling; organozinc reagents; synthetic methods; zinc