title: Hydride-induced anionic cyclization: an efficient method for the synthesis of 6-H-phenanthridines via a transition-metal-free process.
abstract: A novel procedure for hydride-induced anionic cyclization has been developed. It includes the reduction of a biaryl bromo-nitrile with a nucleophilic aromatic substitution (S(N)Ar). A range of polysubstituted 6-H-phenanthridines were so obtained in moderate to good yield with good substrate tolerance. This method involves a concise transition-metal-free process and was applied to synthesize natural alkaloids.
authors.affiliation: Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan.
authors.forename: Wei-Lin
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan.
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan.
authors.forename: Yan-Fu
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Tamkang University, New Taipei City, 25137, Taiwan.
authors.forename: Jen-Chieh
authors.initials: JC
authors.lastname: Hsieh
mesh_terms: D000838:Anions; D003500:Cyclization; D006859:Hydrogen / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000838:Anions; D009570:Nitriles; D010617:Phenanthridines; D006859:Hydrogen