title: Interleukin-2 expression in lupoid and usual types of old world cutaneous leishmaniasis.
abstract: BACKGROUND
  Interleukin (IL)-2 plays a central role in T cell-dependent immune responses.
  
  
  OBJECTIVE
  We conducted this study to determine and compare IL-2 expression in lupoid and usual types of Old World Cutaneous Leishmaniasis (OWCL), using immunohistochemistry.
  
  
  METHODS
  Thirteen paraffin-embedded specimens of lupoid and 12 specimens of usual types of OWCL were used. A mouse monoclonal anti IL-2 antibody was used for staining by the envision technique.
  
  
  RESULTS
  There were strongly stained discrete foci of staining through inflammatory infiltrates of dermis and also in basal layers of epidermis and adnexal structures, with a distinctive pattern of hot spot activity foci (mean of 9.31 ± 6.4 versus 8.17 ± 6.9 foci per HPF for lupoid and usual types, respectively). The expression of IL-2 had no correlation with the pattern of granulomatous inflammation (tuberculoid, sarcoidal or mixed suppurative).
  
  
  CONCLUSIONS
  Interleukin-2 takes part in the immunological response of the granulomatous reaction of OWCL and is not statistically different between lupoid and usual types (P = 0.674).
authors.affiliation: Department of Dermatology, Faculty of Medicine, Rsearch Center for Skin Disease and Cutaneous Leishmaniasis, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Mashayekhi Goyonlo
authors.affiliation: Department of Medicine, Unit of Dermatology and Venereology, Solna, Karolinska Instititutet, Stockholm, Sweden.
authors.forename: Hesameldin
authors.initials: H
authors.lastname: Elnour
authors.affiliation: Department of Medicine, Unit of Dermatology and Venereology, Solna, Karolinska Instititutet, Stockholm, Sweden.
authors.forename: Klas
authors.initials: K
authors.lastname: Nordlind
keywords: Granulomatous; Interleukin-2; Leishmaniasis