title: Neurodegeneration: paying it off with sleep.
abstract: A new study in fruit flies suggests modulation of neural activity links sleep and Alzheimer's disease. Both sleep loss and amyloid beta increase neural excitability, which reinforces the accumulation of amyloid beta and shortens lifespan.
authors.affiliation: Department of Biology, University of Nevada, Reno. Reno, NV 89557, USA. Electronic address: alexckeene@gmail.com.
authors.forename: Alex C
authors.initials: AC
authors.lastname: Keene
authors.affiliation: Department of Pharmacology, Biomedical Sciences Graduate Program, Neurosciences Graduate Program, and Center for Chronobiology, University of California, San Diego, La Jolla, CA 92093-0636, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Joiner
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000502:physiology; D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000473:pathology / Q000503:physiopathology
chemical_list: D016229:Amyloid beta-Peptides