title: Synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics via one-pot sequential lactam reduction/Joullié-Ugi reaction.
abstract: A direct approach to the synthesis of polyhydroxylated piperidine and pyrrolidine peptidomimetics is described. The presented strategy is based on one-pot reduction of sugar-derived lactams with Schwartz's reagent followed by a multicomponent Ugi-Joullié reaction.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Szcześniak
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Maziarz
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Stecko
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences Kasprzaka 44/52, 01-224 Warsaw, Poland.
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Furman
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D007769:Lactams; D057786:Peptidomimetics / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D007769:Lactams; D057786:Peptidomimetics; D010880:Piperidines; D011759:Pyrrolidines; C032727:piperidine; C032519:pyrrolidine