title: [Preparation and characterization of tetrandrine-loaded PLGA nanocomposite particles by premix membrane emulsification coupled with spray-drying method].
abstract: For effective inhalable dry-powder drug delivery, tetrandrine-PLGA (polylactic-co-glycolic acid) nanocomposite particles have been developed to overcome the disadvantages of nanoparticles and microparticles. The primary nanoparticles were prepared by using premix membrane emulsification method. To prepare second particles, they were spray dried. The final particles were characterized by scanning electron microscopy (SEM), dry laser particle size analysis, high performance liquid chromatography (HPLC), X-ray diffraction (XRD), differential scanning calorimetry (DSC), infrared analysis (IR) and confocal laser scanning microscope (CLSM). The average size of the primary particles was (337.5 ± 6.2) nm, while that second particles was (3.675 ± 0.16) μm which can be decomposed into primary nanoparticles in water. And the second particles were solid sphere-like with the drug dispersed as armorphous form in them. It is a reference for components delivery to lung in a new form.
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.forename: Hua-Xu
authors.initials: HX
authors.lastname: Zhu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Guo
authors.forename: Lin-Mei
authors.initials: LM
authors.lastname: Pan
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Fei-Yan
authors.initials: FY
authors.lastname: Shi
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
mesh_terms: D000280:Administration, Inhalation; D044182:Benzylisoquinolines / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D058995:Dry Powder Inhalers; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D004364:Pharmaceutical Preparations; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014961:X-Ray Diffraction
chemical_list: D044182:Benzylisoquinolines; D004364:Pharmaceutical Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; C009438:tetrandrine; D019344:Lactic Acid