title: Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron.
abstract: A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.
authors.affiliation: Department of Informatics, Vytautas Magnus University, Kaunas LT-44404, Lithuania. Electronic address: a.saudargiene@if.vdu.lt.
authors.forename: Aušra
authors.initials: A
authors.lastname: Saudargienė
authors.affiliation: Computer Science and Mathematics, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Graham
mesh_terms: D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D017966:Pyramidal Cells / Q000502:physiology*
keywords: CA1 pyramidal neuron; Dendritic spike; Inhibitory interneurons; Spike-timing-dependent plasticity