title: Vitamin D status and effect of interferon-β1a treatment on MRI activity and serum inflammation markers in relapsing-remitting multiple sclerosis.
abstract: To explore if vitamin D modulates interferon-β1a treatment effects in relapsing-remitting multiple sclerosis, we examined relationships between serum vitamin D and magnetic resonance imaging (MRI) activity and ten systemic inflammation markers in 88 patients, before and during treatment. Odds ratios for all MRI parameters were negatively associated with vitamin D levels before therapy, but converged to equally low values irrespective of vitamin D status during treatment. During therapy, similar alterations of MRI activity and inflammation markers were found across patients categorized by mean vitamin D values. This suggests that vitamin D status has no major influence on interferon-β1a treatment effects.
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: egil.rorvik.rosjo@ahus.no.
authors.forename: Egil
authors.initials: E
authors.lastname: Røsjø
authors.affiliation: Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.affiliation: Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway.
authors.forename: Kristin I
authors.initials: KI
authors.lastname: Løken-Amsrud
authors.affiliation: Department of Neuroradiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Søren J
authors.initials: SJ
authors.lastname: Bakke
authors.affiliation: Multiple Sclerosis Centre Hakadal, Hakadal, Norway.
authors.forename: Antonie G
authors.initials: AG
authors.lastname: Beiske
authors.affiliation: Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Kristian S
authors.initials: KS
authors.lastname: Bjerve
authors.affiliation: Department of Neurology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
authors.forename: Harald
authors.initials: H
authors.lastname: Hovdal
authors.affiliation: Curato Oslo, Oslo, Norway.
authors.forename: Finn
authors.initials: F
authors.lastname: Lilleås
authors.affiliation: Department of Neurology, Molde Hospital, Molde, Norway; Unit for Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
authors.forename: Rune
authors.initials: R
authors.lastname: Midgard
authors.affiliation: Unilabs Drammen, Drammen, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Pedersen
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Helse Sør-Øst Health Services Research Centre, Akershus University Hospital, Lørenskog, Norway.
authors.forename: Jūratė
authors.initials: J
authors.lastname: Šaltytė Benth
authors.affiliation: KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Øivind
authors.initials: Ø
authors.lastname: Torkildsen
authors.affiliation: Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; Norwegian Multiple Sclerosis Competence Centre, Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: Stig
authors.initials: S
authors.lastname: Wergeland
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Annika E
authors.initials: AE
authors.lastname: Michelsen
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section for Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; KG Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
authors.affiliation: Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Trygve
authors.initials: T
authors.lastname: Holmøy
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D009664:Norway; D012044:Regression Analysis; D012189:Retrospective Studies; D013997:Time Factors; D014807:Vitamin D / Q000097:blood*; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D014807:Vitamin D; D016899:Interferon-beta; D000068556:Interferon beta-1a
keywords: Interferon-β treatment; Relapsing-remitting multiple sclerosis; Vitamin D