title: RIG-I works double duty.
abstract: The pathogen sensor RIG-I recognizes viral RNA and signals to induce an antiviral response. In this issue of Cell Host & Microbe, Weber et al. (2015), along with recent work by Sato et al. (2015), demonstrate that RIG-I directly inhibits viral replication independent of antiviral signaling.
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Ying Kai
authors.initials: YK
authors.lastname: Chan
authors.affiliation: Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: michaela_gack@hms.harvard.edu.
authors.forename: Michaela U
authors.initials: MU
authors.lastname: Gack
mesh_terms: D000818:Animals; D005260:Female; D015684:Gene Products, pol / Q000037:antagonists & inhibitors*; D006515:Hepatitis B virus / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000276:immunology*; D022781:Hepatocytes / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012367:RNA, Viral / Q000276:immunology*
chemical_list: D015684:Gene Products, pol; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D012367:RNA, Viral