title: Assessment of potential toxicological aspects of dietary exposure to silicon-rich spirulina in rats.
abstract: Silicon has beneficial effects especially on bones and skin and is important in cardiovascular pathophysiology. Furthermore, in spontaneously hypertensive rats, it reduces hypertension and increases antihypertensive and antiatherogenic gene expressions in the aorta. Thus, incorporating silicon into spirulina could be a way to produce a bioavailable food supplement. The potential toxic effects of silicon-rich spirulina (SES) through haematological and biochemical parameters and inflammatory and oxidative status were evaluated in rats' blood and liver tissue. The study consisted in a 90-day experiment on female and male rats supplemented with three doses (28.5, 57 and 285 mg/kg BW/day) of SES. No mortality, abnormal clinical signs, behavioural changes or macroscopic findings were observed whatever the groups. Haematological parameters were not modified in SES treated-groups. No marked change was recorded in biochemical parameters The liver endogenous antioxidant enzymes (SOD, GPx, catalase) activities were not modified whatever the gender and the dose, just as markers of oxidative stress (O2°(-), TBARS, thiols) and inflammation such as IL-6 and TNF-alpha. Our findings indicate that dietary supplementation of silicon-rich spirulina on rats has no harmful side nor toxic effects and could be beneficial especially in the case of suspicion or installation of pathologies due to oxidative stress.
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University of Montpellier, Place Eugène Bataillon, Montpellier 34095, France.
authors.forename: Joris
authors.initials: J
authors.lastname: Vidé
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University of Montpellier, Place Eugène Bataillon, Montpellier 34095, France.
authors.forename: Cindy
authors.initials: C
authors.lastname: Romain
authors.affiliation: UMR 866 - Dynamic Muscle & Metabolism, INRA Montpellier Center, 2 Place Viala, Montpellier 34060, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Feillet-Coudray
authors.affiliation: UMR 866 - Dynamic Muscle & Metabolism, INRA Montpellier Center, 2 Place Viala, Montpellier 34060, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bonafos
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University of Montpellier, Place Eugène Bataillon, Montpellier 34095, France.
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Cristol
authors.affiliation: UMR 866 - Dynamic Muscle & Metabolism, INRA Montpellier Center, 2 Place Viala, Montpellier 34060, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Fouret
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University of Montpellier, Place Eugène Bataillon, Montpellier 34095, France.
authors.forename: Jean-Max
authors.initials: JM
authors.lastname: Rouanet
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University of Montpellier, Place Eugène Bataillon, Montpellier 34095, France; UMR 866 - Dynamic Muscle & Metabolism, INRA Montpellier Center, 2 Place Viala, Montpellier 34060, France. Electronic address: gaillet@univ-montp2.fr.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Gaillet
mesh_terms: D000821:Animal Feed / Q000032:analysis; D000818:Animals; D005260:Female; D005506:Food Contamination; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D012825:Silicon / Q000009:adverse effects* / Q000737:chemistry*; D053545:Spirulina / Q000737:chemistry*
chemical_list: D012825:Silicon
keywords: Inflammation; Oxidative status; Rats; Silicon; Spirulina; Toxicity