title: Tight glycemic control and cardiovascular effects in type 2 diabetic patients.
abstract: Diabetes Mellitus (DM) with poor glycemic control is one of the leading causes for cardiovascular mortality in diabetic patients. Tight glycemic control with glycosylated haemoglobin of <7 gms% is recommended as a routine and < 6.5 gms% is recommended for young and newly diagnosed diabetics. Treatment goal aims at achieving near normal blood glucose level, and directed at management of other co morbid conditions such as obesity, hypertension and dyslipidemia. Oral hypoglycemic agents are the preferred drugs, alone or in combination. Preference for glitazones is declining due to the increasing evidences of associated adverse events. Gliptins appear as promising agents with lesser tendency to cause hypoglycemia, but their long term safety and efficacy is yet to be established. We emphasize the role of preventive measures in prediabetics and in established DM, treatment should be individualized and customized to minimize hypoglycemic effects and to retain quality of life.
authors.affiliation: Dr. Reddy's Laboratories Ltd., Hyderabad Telangana, India.
authors.forename: Latha Subramanya
authors.initials: LS
authors.lastname: Moodahadu
authors.affiliation: Consultant Physician, Ahmedabad, Gujarat, India.
authors.forename: Ruchi
authors.initials: R
authors.lastname: Dhall
authors.affiliation: Member Institute Body, AIIMS and Endocrinologist, Advanced Center for Diabetes and Endocrine Care, Srinagar, Jammu and Kashmir, India.
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar
authors.affiliation: Program Director, Clinical Development Service Agency, Gurgaon, India.
authors.forename: Sudhakar
authors.initials: S
authors.lastname: Bangera
authors.affiliation: General Practitioner and Family Physician, Hyderabad, Telangana, India.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Ramani
authors.affiliation: Dr. Reddy's Laboratories Ltd., Hyderabad Telangana, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Katipally
keywords: Diabetes mellitus; gliptins; non pharmacological measures; oral hypoglycemic agents; tight glycemic control