title: Content of circulating extracellular DNA, plasma activities of matrix metalloproteinases, and ultrastructure of the myocardium in hypothyroid rats with hypercholesterolemia.
abstract: Free circulating extracellular DNA, plasma activities of matrix metalloproteinases in hypothyroid rats, and ultrastructural changes in the myocardium were studied under conditions of experimental hypercholesterolemia. For suppression of thyroid function, the animals received antithyroid drug mercazolyl under conditions of cholesterol diet. Hypercholesterolemia in hypothyroid rats (thyroxine concentration 2-fold below the normal) was paralleled by a pronounced increase of the concentration of free circulating extracellular DNA and total matrix metalloproteinases 2 and 7 activity. These changes were associated with lytic and destructive changes in cardiomyocytes and blood capillary endotheliocytes. Changes in the cardiomyocyte and endotheliocyte ultrastructure were more pronounced in hypothyroid rats.
authors.affiliation: Research Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, pathol@inbox.ru.
authors.forename: L M
authors.initials: LM
authors.lastname: Polyakov
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: A A
authors.initials: AA
authors.lastname: Karpova
authors.forename: G S
authors.initials: GS
authors.lastname: Russkikh
authors.forename: O N
authors.initials: ON
authors.lastname: Poteryaeva
authors.forename: D B
authors.initials: DB
authors.lastname: Nikityuk
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
authors.forename: Zh I
authors.initials: ZhI
authors.lastname: Belonogova
authors.forename: D V
authors.initials: DV
authors.lastname: Sumenkova
authors.forename: R D
authors.initials: RD
authors.lastname: Nepomnyashchikh
authors.forename: V I
authors.initials: VI
authors.lastname: Pichigin
mesh_terms: D000818:Animals; D004247:DNA / Q000097:blood*; D006937:Hypercholesterolemia / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood* / Q000139:chemically induced; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020783:Matrix Metalloproteinase 7 / Q000097:blood; D020782:Matrix Metalloproteinases / Q000097:blood*; D008713:Methimazole / Q000627:therapeutic use; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008713:Methimazole; D004247:DNA; D020782:Matrix Metalloproteinases; D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2