title: The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study.
abstract: Nonsurgical hypoparathyroidism (HypoPT) is a rare disorder most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low PTH levels. Knowledge about this group of patients, including their mortality and morbidity, is very sparse. The aim was to identify all patients diagnosed with nonsurgical HypoPT in Denmark and assess their mortality and risk of complications. Through registers and review of individual patient hospital charts we identified all patients diagnosed with nonsurgical HypoPT in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age- and gender-matched population-based controls. We identified a total of 180 patients with nonsurgical HypoPT among whom 123 (68%) were alive at the date of follow-up (prevalence of 2.3/100,000 inhabitants). Compared with controls, mortality was not increased, but patients had a significantly increased risk of renal insufficiency (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), cataract (HR 4.21), and fractures at the upper extremities (HR 1.93). In contrast patients had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical HypoPT is a rare disease associated with a number of complications that should be considered when taking care of these patients.
authors.affiliation: Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Line
authors.initials: L
authors.lastname: Underbjerg
authors.affiliation: Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Tanja
authors.initials: T
authors.lastname: Sikjaer
authors.affiliation: Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Leif
authors.initials: L
authors.lastname: Mosekilde
authors.affiliation: Department of Endocrinology and Internal Medicine, Tage-Hansens Gade (THG), Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Rejnmark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications; D016022:Case-Control Studies; D002386:Cataract / Q000150:complications; D002648:Child; D002675:Child, Preschool; D003625:Data Collection; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000150:complications / Q000453:epidemiology; D006801:Humans; D006996:Hypocalcemia / Q000150:complications / Q000453:epidemiology; D007011:Hypoparathyroidism / Q000150:complications / Q000453:epidemiology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D001523:Mental Disorders / Q000150:complications; D008875:Middle Aged; D009154:Mutation; D009369:Neoplasms / Q000150:complications; D016016:Proportional Hazards Models; D012042:Registries; D051437:Renal Insufficiency / Q000150:complications; D012189:Retrospective Studies; D012640:Seizures / Q000150:complications; D055815:Young Adult
keywords: EPIDEMIOLOGY; OTHER THERAPEUTICS; PARATHYROID-RELATED DISORDERS