title: Copper-Catalyzed Synthesis ofN-Aryl andN-Sulfonyl Indoles from 2-Vinylanilines with O2as Terminal Oxidant and TEMPO as Co-Catalyst.
abstract: A copper-catalyzed intramolecular alkene oxidative amination that utilizes TEMPO as co-catalyst and O2as the terminal oxidant has been developed. The method furnishesN-aryl andN-sulfonyl indoles fromN-aryl andN-sulfonyl 2-vinylanilines, respectively. Additionally, sequential copper-catalyzed reactions where initial Chan-Lam coupling of 2-vinylanilines with arylboronic acids is followed by oxidative amination of the alkene can generateN-aryl indoles in one pot.
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY, 14620, United States.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Liwosz
authors.affiliation: Department of Chemistry, The State University of New York at Buffalo, Buffalo, NY, 14620, United States.
authors.forename: Sherry R
authors.initials: SR
authors.lastname: Chemler
keywords: TEMPO; copper; indoles; oxidation; oxygen