title: Delivery rates after elective single cryopreserved embryo transfer related to embryo survival.
abstract: OBJECTIVE
  The objective of this study was to assess if eSCET (elective Single Cryopreserved Embryo Transfer) outcome is related to blastomere survival rate. The final objective was to avoid multiple pregnancies and offer the best chances to women to achieve pregnancy even during their frozen-thawed embryo transfer (FET) cycles.
  
  
  METHODS
  Patients were included in this prospective observational study if they met the following criteria: (i) women age <37 years old; (ii) IVF of ICSI cycle rank ≤2, (iii) eSET proposed during fresh embryo transfer cycle and (iv) ≥1 good quality cryopreserved embryos available (<20% fragmentation and 4-5 blastomeres at day-2 or 7-9 blastomeres at day-3). Live birth rates (LBR) were compared into eSCET groups according to embryo survival (partially damaged or intact transferred embryo).
  
  
  RESULTS
  We observed among selected patients, that partial loss of blastomeres (1 blastomere for day-2 embryos, 1 or 2 blastomeres for day-3 embryos) following FET cycles did not affect LBR compared with intact embryo.
  
  
  CONCLUSIONS
  These results underline the relevance of eSCET as a strategy to reduce multiple pregnancies frequency without reducing LBR.
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France; Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, Bobigny 93017, France.
authors.forename: C
authors.initials: C
authors.lastname: Dupont
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: E
authors.initials: E
authors.lastname: Hafhouf
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France; Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, Bobigny 93017, France.
authors.forename: N
authors.initials: N
authors.lastname: Sermondade
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: O
authors.initials: O
authors.lastname: Sellam
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: C
authors.initials: C
authors.lastname: Herbemont
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: J
authors.initials: J
authors.lastname: Boujenah
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France; Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, Bobigny 93017, France.
authors.forename: C
authors.initials: C
authors.lastname: Faure
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France; Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, Bobigny 93017, France.
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: C
authors.initials: C
authors.lastname: Poncelet
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: J N
authors.initials: JN
authors.lastname: Hugues
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: I
authors.initials: I
authors.lastname: Cedrin-Durnerin
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: C
authors.initials: C
authors.lastname: Sonigo
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service de médecine de la reproduction, pôle femme-et-enfant, Bondy 93140, France.
authors.forename: M
authors.initials: M
authors.lastname: Grynberg
authors.affiliation: AP-HP, hôpital Jean Verdier, HUPSSD, Service d'histologie-embryologie-cytogénétique-BDR-CECOS, pôle femme-et-enfant, Bondy 93140, France; Université Paris 13, Sorbonne Paris Cité, Unité de Recherche en Epidémiologie Nutritionnelle, UMR U557 Inserm, U1125 Inra, Cnam, CRNH IdF, Bobigny 93017, France. Electronic address: christophe.sifer@jvr.aphp.fr.
authors.forename: C
authors.initials: C
authors.lastname: Sifer
mesh_terms: D000328:Adult; D001757:Blastomeres / Q000502:physiology*; D002470:Cell Survival; D015925:Cryopreservation; D005260:Female; D006801:Humans; D050498:Live Birth; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D056826:Single Embryo Transfer / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic
keywords: Blastomere loss; FET cycles; Live birth rate; eSCET; eSET