title: Signalling scaffolds and local organization of cellular behaviour.
abstract: Cellular responses to environmental cues involve the mobilization of GTPases, protein kinases and phosphoprotein phosphatases. The spatial organization of these signalling enzymes by scaffold proteins helps to guide the flow of molecular information. Allosteric modulation of scaffolded enzymes can alter their catalytic activity or sensitivity to second messengers in a manner that augments, insulates or terminates local cellular events. This Review examines the features of scaffold proteins and highlights examples of locally organized groups of signalling enzymes that drive essential physiological processes, including hormone action, heart rate, cell division, organelle movement and synaptic transmission.
authors.affiliation: Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA.
authors.forename: Lorene K
authors.initials: LK
authors.lastname: Langeberg
authors.affiliation: Howard Hughes Medical Institute and Department of Pharmacology, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Scott
mesh_terms: D000818:Animals; D002468:Cell Physiological Phenomena; D002477:Cells / Q000201:enzymology; D005812:Genes, Switch / Q000235:genetics; D006801:Humans; D008954:Models, Biological; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D034521:Nuclear Matrix-Associated Proteins