title: Effects of red wine on postprandial stress: potential implication in non-alcoholic fatty liver disease development.
abstract: BACKGROUND
  Red wine consumption is considered to be protective against oxidative stress. Diet strongly influences non-alcoholic fatty liver disease, which is associated with oxidative stress and is considered the hepatic manifestation of the metabolic syndrome.
  
  
  METHODS
  We reviewed the available evidence that investigated the effects of red wine on the postprandial-induced metabolic and oxidative stress in humans.
  
  
  RESULTS
  After red wine consumption with meal, despite the improvement in non-enzymatic antioxidant capacity and lipoperoxidation markers, the influence of confounding factors such as uric acid should be taken into account. Both uric acid and triglycerides increases, induced by ethanol, could cause liver damage. On the other hand, further researches are required in order to understand the meaning of the induction of antioxidant enzymes by red wine and red wine polyphenols in the context of non-alcoholic fatty liver disease.
  
  
  CONCLUSIONS
  In conclusion, inconsistent and contrasting findings exist regarding the potential benefits of red wine consumption against postprandial stress.
authors.affiliation: Food and Nutrition Center of the Agricultural Research Council (CRA-NUT), Via Ardeatina 546, 00178, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Peluso
authors.forename: Husseen
authors.initials: H
authors.lastname: Manafikhi
authors.forename: Raffaella
authors.initials: R
authors.lastname: Reggi
authors.forename: Maura
authors.initials: M
authors.lastname: Palmery
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood*; D018384:Oxidative Stress; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014920:Wine / Q000032:analysis*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014280:Triglycerides; D014527:Uric Acid