title: The relationship between dietary protein consumption and risk of fracture: a subgroup and dose-response meta-analysis of prospective cohort studies.
abstract: It is still debate of the relationship between the dietary protein consumption and risk of fracture. We searched Medline and Embase to assess the effects of dietary protein consumption on risk of fracture. Twelve prospective cohort studies with 407,104 participants were included, higher total protein consumption may be decrease 11% risk of hip fractures, with adj. RR of 0.89 (0.82, 0.97), no significant difference was found for total protein and risk of all fractures and limb fracture; for animal protein consumption and risk of all fractures and hip fracture, with adj.RR of 0.79 (032, 1.96) and 1.04 (0.70, 1.54); for vegetable protein consumption and risk of all fractures, hip fracture and limb fractures with adj.RR of 0.77 (0.52, 1.12), 1.00 (0.53, 1.91), and 0.94 (0.40, 2.22), the subgroup of vegetable protein consumption and risk of all fractures of postmenopausal women with adj.RR of 0.78(0.52,1.16). Dose-response meta-analysis the relationship of total/animal/vegetable protein and hip fracture was consistent to the results of forest plot, the line of total protein and hip fracture was below the Y = 1.0 line. This meta-analysis showed that total dietary protein consumption may be decrease the risk of hip fracture, but not for animal or vegetable protein.
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Wu
authors.affiliation: Department of Orthopaedics, Tianjin hospital, 406 Jiefang Nan Road. 300211, Tianjin, China.
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Sun
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Qing-Bo
authors.initials: QB
authors.lastname: Lv
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Orthopaedics, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road. 200120Pudong, Shanghai, China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Xia
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Hua-Zi
authors.initials: HZ
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Qi-Shan
authors.initials: QS
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics, Second Affiliated Hospital of Wenzhou Medical University, 109# XueYuan Xi Road. 325027, Wenzhou, Zhejiang, China.
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Chi
mesh_terms: D000818:Animals; D015331:Cohort Studies; D004032:Diet; D004044:Dietary Proteins / Q000008:administration & dosage; D050723:Fractures, Bone / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D016017:Odds Ratio; D011446:Prospective Studies; D017594:Publication Bias; D012306:Risk
chemical_list: D004044:Dietary Proteins