title: Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure.
abstract: BACKGROUND
  BCL-2-associated athanogene 3 (BAG3) is a protein implicated in the cardiomyocyte stress response and genesis of cardiomyopathy. Extracellular BAG3 is measurable in patients with heart failure (HF), but the relationship of BAG3 with HF prognosis is unclear.
  
  
  METHODS
  BAG3 plasma concentrations were measured in 39 acutely decompensated HF patients; the primary endpoint was death at 1 year. Baseline characteristics were compared by vital status and median BAG3 concentration. Correlation of BAG3 with left ventricular ejection fraction (LVEF) and other biomarkers was performed. Prognostic value was assessed using Cox proportional hazards regression and Kaplan-Meier analysis.
  
  
  RESULTS
  At baseline, median BAG3 was significantly higher in decedents (N=11) than survivors (N=28; 1489 ng/mL versus 50 ng/mL; P=0.04); decedents also had worse renal function and higher median natriuretic peptide (NP) and sST2. BAG3 was not significantly correlated with NPs, mid-regional pro-adrenomedullin, sST2, or eGFR, however. Mortality was increased in patients with supra-median BAG3 (>336 ng/mL; 42.1% versus 15.0%, P=0.06). In age and LVEF-adjusted Cox proportional hazards, BAG3 remained a significant mortality predictor (HR=3.20; 95% CI=1.34-7.65; P=0.02); those with supra-median BAG3 had significantly shorter time-to-death (P=0.04).
  
  
  CONCLUSIONS
  The stress response protein BAG3 is measurable in patients with ADHF and may be prognostic for death.
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Parul U
authors.initials: PU
authors.lastname: Gandhi
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Hanna K
authors.initials: HK
authors.lastname: Gaggin
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Arianna M
authors.initials: AM
authors.lastname: Belcher
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: Jamie E
authors.initials: JE
authors.lastname: Harisiades
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano, SA, Italy; BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Basile
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano, SA, Italy; BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy.
authors.forename: Antonia
authors.initials: A
authors.lastname: Falco
authors.affiliation: Department of Pharmacy, University of Salerno, Fisciano, SA, Italy; BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rosati
authors.affiliation: Department of Medicine and Surgery, University of Salerno, Baronissi, SA, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Piscione
authors.affiliation: Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States.
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.affiliation: BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy; Department of Medicine and Surgery, University of Salerno, Baronissi, SA, Italy. Electronic address: mcturco@unisa.it.
authors.forename: M Caterina
authors.initials: MC
authors.lastname: Turco
mesh_terms: D000208:Acute Disease; D048868:Adaptor Proteins, Signal Transducing / Q000097:blood* / Q000235:genetics; D053607:Adrenomedullin / Q000097:blood / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D051017:Apoptosis Regulatory Proteins / Q000097:blood* / Q000235:genetics; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D066246:ErbB Receptors / Q000097:blood / Q000235:genetics; D005260:Female; D015870:Gene Expression; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality; D006352:Heart Ventricles / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D007677:Kidney Function Tests; D008297:Male; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood / Q000235:genetics; D013318:Stroke Volume; D016019:Survival Analysis
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C414431:BAG3 protein, human; D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor; C512478:EGFR protein, human; D066246:ErbB Receptors
keywords: BAG3; BCL-2 athanogene 3; Heart failure; Prognosis