title: Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.
abstract: Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.
authors.affiliation: Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, California.
authors.forename: Alexander
authors.initials: A
authors.lastname: Scholz
authors.affiliation: Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.|German Center for Cardiovascular Research (DZHK), Frankfurt, Germany.|German Cancer Consortium (DKTK), Frankfurt, Germany.|German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Karl H
authors.initials: KH
authors.lastname: Plate
authors.affiliation: Edinger Institute/Institute of Neurology, Frankfurt University Medical School, Frankfurt, Germany.|German Center for Cardiovascular Research (DZHK), Frankfurt, Germany.|German Cancer Consortium (DKTK), Frankfurt, Germany.|German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Reiss
mesh_terms: D042702:Angiopoietin-2 / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D018805:Sepsis / Q000276:immunology; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: C586513:ANGPT2 protein, human; D042702:Angiopoietin-2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: Ang-2; angiopoietin; inflammation; innate immune cell; myeloid cell