title: Alginate microspheres obtained by the spray drying technique as mucoadhesive carriers of ranitidine.
abstract: The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers--gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9%. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach.
authors.forename: Marta
authors.initials: M
authors.lastname: Szekalska
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Amelian
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Winnicka
mesh_terms: D000268:Adhesiveness; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005753:Gastric Mucosa / Q000378:metabolism; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000737:chemistry; D008863:Microspheres; D010316:Particle Size; D011899:Ranitidine / Q000008:administration & dosage* / Q000737:chemistry; D013552:Swine
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D020723:Glucuronic Acid