title: [Infection due to Mycobacterium bovis in common variable immunodeficiency].
abstract: Common variable immunodeficiency (CVID) is an heterogeneous group of disorders characterized by impaired antibody production. It shows a wide spectrum of manifestations including severe and recurrent respiratory infections (Streptococcus pneumoniae, Haemophilus) and gastrointestinal (Campylobacter jejuni, rotavirus and Giardia lamblia). Viral infections caused by herpes zoster, cytomegalovirus (CMV) and hepatitis C are rare. The opportunistic agents such as CMV, Pneumocystis jirovecii, cryptococcus and atypical mycobacteria have been reported as isolated cases. This paper reports the case of a 38-year-old female patient, who began six years before with weight loss of 7 kg in six months, fatigue, weakness, sweating, fever and abdominal pain. Furthermore, patient had intestinal obstruction and abdominal CT showed mesenteric lymph growth. The mesenteric lymph node biopsy revealed positives Mycobacterium PCR, Ziehl-Neelsen staining and culture for M. bovis. In the laparotomy postoperative period was complicated with nosocomial pneumonia, requiring mechanical ventilation and tracheostomy. Two years later, she developed right renal abscess that required surgical drainage, once again with a positive culture for Mycobacterium bovis. She was referred to highly specialized hospital and we documented panhypogammaglobulinemia and lymphopenia. Secondary causes of hypogammaglobulinemia were ruled out and common variable immunodeficiency (CVID) was confirmed, we started IVIG replacement. Four years later she developed mixed cellularity Hodgkin's lymphoma. Until today she continues with IVIG and chemotherapy. This report of a patient with CVID and Mycobacterium bovis infection, a unusual association, shows the cellular immunity susceptibility in this immunodeficiency, additional to the humoral defect.
authors.affiliation: Servicio de Inmunología Clínica y Alergia, Centro Médico Nacional 20 de Noviembre, ISSSTE, México, Distrito Federal. saraelvaespino@gmail.com.
authors.forename: Diana Andrea
authors.initials: DA
authors.lastname: Herrera-Sánchez
authors.forename: Jaisel Luz
authors.initials: JL
authors.lastname: Castilla-Rodríguez
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Castrejón-Vázquez
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Vargas-Camaño
authors.forename: Edgar Alejandro
authors.initials: EA
authors.lastname: Medina-Torres
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Blancas-Galicia
authors.forename: Sara Elva
authors.initials: SE
authors.lastname: Espinosa-Padilla
keywords: Common variable immunodeficiency; Hodgkin’s lymphoma; Humoral immunodeficiency; Hypogammaglobulinemia; Mycobacterium bovis