title: Hydroamination reactions of alkynes with ortho-substituted anilines in ball mills: synthesis of benzannulated N-heterocycles by a cascade reaction.
abstract: It was demonstrated that ortho-substituted anilines are prone to undergo hydroamination reactions with diethyl acetylenedicarboxylate in a planetary ball mill. A sequential coupling of the intermolecular hydroamination reaction with intramolecular ring closure was utilized for the syntheses of benzooxazines, quinoxalines, and benzothiazines from readily available building blocks, that is, electrophilic alkynes and anilines with OH, NH, or SH groups in the ortho position. For the heterocycle formation, it was shown that several stress conditions were able to initiate the reaction in the solid state. Processing in a ball mill seemed to be advantageous over comminution with mortar and pestle with respect to process control. In the latter case, significant postreaction modification occurred during solid-state analysis. Cryogenic milling proved to have an adverse effect on the molecular transformation of the reagents.
authors.affiliation: Institute for Technical Chemistry and Environmental Chemistry, Friedrich Schiller University Jena, Lessingstrasse 12, 07743 Jena (Germany).
authors.forename: Maik
authors.initials: M
authors.lastname: Weiße
authors.forename: Markus
authors.initials: M
authors.lastname: Zille
authors.forename: Katharina
authors.initials: K
authors.lastname: Jacob
authors.forename: Robert
authors.initials: R
authors.lastname: Schmidt
authors.forename: Achim
authors.initials: A
authors.lastname: Stolle
keywords: IR spectroscopy; cascade reactions; hydroamination; nitrogen heterocycles; solid-state reactions