title: Autophagy does not lead to the asymmetrical hippocampal injury in chronic stress.
abstract: Chronic stress results in hippocampal injury, and impairs learning and memory ability of animals. However the cellular mechanisms underlying cell death within hippocampus remain elusive. The present employed the rat model of chronic unpredicted mild stress (CUMS) and examined the cellular mechanism responsible for learning and memory impairments. The results showed that in correlation to the decreased ability in novelty cognition and reverse learning, CUMS led to loss of CA3 neurons in hippocampus, especially in the right hippocampus. Interestingly, autophagy contributed to the cell loss but was asymmetrical on both sides. This suggested that CUMS resulted in asymmetrical hippocampal injuries, which is not fully determined by autophagy.
authors.affiliation: Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China. Electronic address: 13505818948@163.com.
authors.forename: Gonglin
authors.initials: G
authors.lastname: Hou
authors.affiliation: Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Psychology, Zhejiang Sci-Tech University, Hangzhou, China.
authors.forename: Xiangsi
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, China. Electronic address: ytf0707@126.com.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
mesh_terms: D000818:Animals; D001343:Autophagy; D001930:Brain Injuries / Q000209:etiology* / Q000473:pathology*; D002452:Cell Count; D004195:Disease Models, Animal; D004597:Electroshock / Q000009:adverse effects; D005508:Food Deprivation; D006624:Hippocampus / Q000473:pathology*; D008297:Male; D018782:Maze Learning; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013315:Stress, Psychological / Q000150:complications* / Q000209:etiology; D014868:Water Deprivation
chemical_list: D008869:Microtubule-Associated Proteins; C526109:Anxa3 protein, rat
keywords: Autophagy; Chronic mild stress; Chronic stress; Hippocampus; Morris water maze; Reverse learning; Unpredicted