title: The double life of connexin channels: single is a treat.
abstract: Although several genetic diseases are caused by mutations in channels made by connexin family members, there has been little progress in the development and validation of therapeutic options. An in vitro study in this issue of JID suggests that an anti-malarial drug may be beneficial in keratitis-ichthyosis deafness, a severe conexin channel disease associated with potentially fatal recurrent infections.
authors.affiliation: HKU-Pasteur Research Pole, School of Public Health The University of Hong Kong, Hong Kong, People's Republic of China; Department of Cell Biology and Infection, Institut Pasteur, Paris, France. Electronic address: bruzzone@hku.hk.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bruzzone
mesh_terms: D000818:Animals; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D006801:Humans; D007634:Keratitis / Q000378:metabolism; D015767:Mefloquine / Q000737:chemistry*
chemical_list: D017630:Connexins; D000072259:Connexin 26; D015767:Mefloquine