title: Prevalence and clinical burden of NDM-1 positive infections in pediatric and neonatal patients in Pakistan.
abstract: In a neonatal/pediatric Gram-negative infection study from Islamabad, 71/82 strains were carbapenem resistant with 12/82 positive for New Delhi Metallo-β-lactamase and many being extensively antibiotic resistant. Burden and outcome analysis on 9 patients showed that 4/9 died after inadequate therapy regardless of organism type.
authors.affiliation: From the *Department of Microbiology, Quaid-i-Azam University, Islamabad, 45320 Pakistan; †School of Medicine, Department of Infection, Immunity and Biochemistry, Cardiff University, Heath Park, Cardiff, United Kingdom; and ‡Department of Microbiology and Pathology, Pakistan Institute of Medical Sciences Hospital, Islamabad, Pakistan.
authors.forename: Muhammad Usman
authors.initials: MU
authors.lastname: Qamar
authors.forename: Fouzia
authors.initials: F
authors.lastname: Nahid
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Walsh
authors.forename: Rubina
authors.initials: R
authors.lastname: Kamran
authors.forename: Rabaab
authors.initials: R
authors.lastname: Zahra
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D015780:Carbapenems / Q000494:pharmacology; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000201:enzymology* / Q000302:isolation & purification*; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D010154:Pakistan / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D016019:Survival Analysis; D001618:beta-Lactamases / Q000032:analysis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1