title: Viral gene therapy for head and neck cancer.
abstract: BACKGROUND
  Viral gene therapy is a promising new treatment modality for head and neck cancer. This paper provides the reader with a review of the relevant literature in this field.
  
  
  RESULTS
  There are government licensed viral gene therapy products currently in use for head and neck cancer, utilised in conjunction with established treatment modalities. The viruses target tumour-associated genes, with the first licensed virus replacing p53 gene function, which is frequently lost in tumourigenesis. Oncolytic viruses selectively destroy cancer cells through viral replication and can be armed with therapeutic transgenes.
  
  
  CONCLUSIONS
  Despite considerable advances in this field over the last 40 years, further research is needed to improve the overall efficacy of the viruses and allow their widespread utilisation in the management of head and neck cancer.
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London,UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Hughes
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London,UK.
authors.forename: G
authors.initials: G
authors.lastname: Alusi
authors.affiliation: Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London,UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D018014:Gene Transfer Techniques; D016158:Genes, p53; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000502:physiology*; D014779:Virus Replication
keywords: Oncolytic Virotherapy