title: Direct oligonucleotide-photosensitizer conjugates for photochemical delivery of antisense oligonucleotides.
abstract: Activation of photosensitizers in endosomes enables release of therapeutic macromolecules into the cytosol of the target cells for pharmacological actions. In this study, we demonstrate that direct conjugation of photosensitizers to oligonucleotides (ONs) allows spatial and temporal co-localization of the two modalities in the target cells, and thus leads to superior functional delivery of ONs. Further, light-activated delivery of an anticancer ON caused cancer cell killing via modulation of an oncogene and photodynamic therapy.
authors.affiliation: Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA. xming@email.unc.edu.
authors.forename: Ahu
authors.initials: A
authors.lastname: Yuan
authors.forename: Brian
authors.initials: B
authors.lastname: Laing
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Ming
mesh_terms: D001692:Biological Transport; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008027:Light; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016376:Oligonucleotides, Antisense; D017319:Photosensitizing Agents