title: [What is the optimal oxygen saturation for extremely premature infants? A Meta analysis].
abstract: OBJECTIVE
  To explore an optimal oxygen saturation for extremely preterm infants based on a systemic review of the published studies.
  
  
  METHODS
  A Meta analysis of the published studies by the NeOProM Group which compared the outcomes of extremely preterm infants (gestational age <28 weeks) maintained in either a low (85%-89%) or high (91%-95%) oxygen saturation (SpO2) by using the STATA 12.0. The outcomes measured included the mortality and the incidences of retinopathy of prematurity (ROP), necrotizing enterocolitis of newborn (NEC), broncho-pulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) and patent ductus arteriosus (PDA).
  
  
  RESULTS
  Three studies were included, in which 2 460 infants were assigned into the low SpO2 group and 2 459 infants in the high SpO2 group. The Meta analysis demonstrated that the risk of mortality before discharge or at the age of 18 months increased in the low SpO2 group compared with the high SpO2 group (RR: 1.19; 95%CI: 1.05-1.35); the risk of ROP decreased in the low SpO2 group (RR: 0.73; 95%CI: 0.53-1.00); the risk of NEC increased in the low SpO2 group (RR: 1.26; 95%CI: 1.06-1.49). There was no significance in the incidences of BPD, IVH and PDA between the two groups.
  
  
  CONCLUSIONS
  Maintaining SpO2 at 85%-89% may decrease the incidence of ROP, but increase the mortality rate and the incidence of NEC in extremely premature infants.
authors.affiliation: Department of Neonatology, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China. jing.lin@mssm.edu.
authors.forename: Jing-Yang
authors.initials: JY
authors.lastname: Li
authors.forename: Zhen-Lang
authors.initials: ZL
authors.lastname: Lin
authors.forename: Jia
authors.initials: J
authors.lastname: Wei
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Yan
authors.forename: Jin
authors.initials: J
authors.lastname: Lin
mesh_terms: D020345:Enterocolitis, Necrotizing / Q000209:etiology; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D062071:Infant, Extremely Premature / Q000378:metabolism*; D017063:Outcome Assessment, Health Care; D010100:Oxygen / Q000097:blood*; D012178:Retinopathy of Prematurity / Q000209:etiology
chemical_list: D010100:Oxygen