title: Impact of adolescent sucrose access on cognitive control, recognition memory, and parvalbumin immunoreactivity.
abstract: In this study we sought to determine the effect of daily sucrose consumption in young rats on their subsequent performance in tasks that involve the prefrontal cortex and hippocampus. High levels of sugar consumption have been associated with the development of obesity, however less is known about how sugar consumption influences behavioral control and high-order cognitive processes. Of particular concern is the fact that sugar intake is greatest in adolescence, an important neurodevelopmental period. We provided sucrose to rats when they were progressing through puberty and adolescence. Cognitive performance was assessed in adulthood on a task related to executive function, a rodent analog of the Stroop task. We found that sucrose-exposed rats failed to show context-appropriate responding during incongruent stimulus compounds presented at test, indicative of impairments in prefrontal cortex function. Sucrose exposed rats also showed deficits in an on object-in-place recognition memory task, indicating that both prefrontal and hippocampal function was impaired. Analysis of brains showed a reduction in expression of parvalbumin-immunoreactive GABAergic interneurons in the hippocampus and prefrontal cortex, indicating that sucrose consumption during adolescence induced long-term pathology, potentially underpinning the cognitive deficits observed. These results suggest that consumption of high levels of sugar-sweetened beverages by adolescents may also impair neurocognitive functions affecting decision-making and memory, potentially rendering them at risk for developing mental health disorders.
authors.affiliation: School of Psychology, University of New South Wales Australia, Kensington, Sydney, New South Wales 2052, Australia a.reichelt@unsw.edu.au.
authors.forename: Amy C
authors.identifier: http://orcid.org/0000-0002-0637-0411
authors.initials: AC
authors.lastname: Reichelt
authors.affiliation: School of Psychology, University of New South Wales Australia, Kensington, Sydney, New South Wales 2052, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Killcross
authors.affiliation: School of Psychology, University of New South Wales Australia, Kensington, Sydney, New South Wales 2052, Australia.
authors.forename: Luke D
authors.initials: LD
authors.lastname: Hambly
authors.affiliation: School of Medical Science, University of New South Wales Australia, Kensington, Sydney, New South Wales 2052, Australia.
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Morris
authors.affiliation: School of Psychology, University of New South Wales Australia, Kensington, Sydney, New South Wales 2052, Australia.
authors.forename: R Fred
authors.initials: RF
authors.lastname: Westbrook
mesh_terms: D000818:Animals; D003071:Cognition / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D019422:Dietary Sucrose / Q000008:administration & dosage*; D004192:Discrimination, Psychological / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D059330:GABAergic Neurons / Q000502:physiology*; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology; D007150:Immunohistochemistry; D007395:Interneurons / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009483:Neuropsychological Tests; D010320:Parvalbumins / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000254:growth & development / Q000502:physiology; D017207:Rats, Sprague-Dawley; D021641:Recognition, Psychology / Q000502:physiology*
chemical_list: D019422:Dietary Sucrose; D010320:Parvalbumins