title: Animal models of systemic sclerosis.
abstract: Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.
authors.forename: Florence
authors.initials: F
authors.lastname: Morin
authors.forename: Niloufar
authors.initials: N
authors.lastname: Kavian
authors.affiliation: Laboratoire d'Immunologie, INSERM U1016, Institut Cochin, Faculte de Medecine Paris Descartes et Laboratoire d'immunologie biologique, Hopital Cochin, 24 rue du faubourg St Jacques 75679 Paris cedex 14, France. frederic.batteux@cch.aphp.fr.
authors.forename: Frederic
authors.initials: F
authors.lastname: Batteux
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D012595:Scleroderma, Systemic / Q000276:immunology / Q000473:pathology* / Q000628:therapy