title: The association of MC4R rs17782313 polymorphism with dietary intake in Iranian adults.
abstract: BACKGROUND
  Malfunction in the energy homeostasis system is a major cause of developing obesity. Melanocortin-4 receptor (MC4R) plays a crucial role in this system as a key receptor. Although MC4R gene as an obesity candidate gene is associated with higher BMI, only few attempts have been carried out to understand the mechanism underlying body-weight regulation.
  
  
  OBJECTIVE
  The aim of this study is to investigate the association between variant rs17782313 near MC4R gene and both dietary energy and macronutrient intakes.
  
  
  METHODS
  An Iranian population, 400 adults aged over 22years were selected from the Iranian Multicenter Osteoporosis Study (IMOS). Genotyping for the near MC4R rs17782313 was performed by PCR-RFLP. Weight and height were measured. Dietary intake and physical activity were assessed by using validated questionnaires. Analysis was carried out in two groups with regard to BMI. Multiple linear regression models adjusted for covariates were used to examine the association between rs17782313 and dietary intake.
  
  
  RESULTS
  MC4R rs17782313 was associated with high energy intake (P<0.001), and low carbohydrate and protein intakes (P<0.001 and P<0.01 respectively). In addition, the significant association between variant rs17782313 and fat intake disappeared after adjusting for energy.
  
  
  CONCLUSIONS
  The rs17782313 variant contributes to the variety of dietary energy and energy-dense macronutrient intakes. Moreover, a novel association was suggested between this polymorphism and dietary fat intake.
authors.affiliation: Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azadeh
authors.initials: A
authors.lastname: Khalilitehrani
authors.affiliation: School of Medicine, Community Medicine Department, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Qorbani
authors.affiliation: Endocrinology and Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Hosseini
authors.affiliation: Department of Cellular-Molecular Nutrition, School of Nutrition Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: pishvahm@tums.ac.ir.
authors.forename: Hamideh
authors.initials: H
authors.lastname: Pishva
mesh_terms: D000328:Adult; D004032:Diet; D002149:Energy Intake; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006026:Glycoside Hydrolases / Q000378:metabolism; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000378:metabolism; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C470072:MC4R protein, human; D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; D006026:Glycoside Hydrolases; C019822:carbohydrase
keywords: Dietary intake; Melanocortin receptor 4 (MC4R); Obesity; Polymorphism