title: Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency.
abstract: We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress.
authors.affiliation: a Faculty of Applied Bioscience, Department of Nutritional Science and Food Safety , Tokyo University of Agriculture , Tokyo , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Inoue
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Moussa
authors.initials: M
authors.lastname: Ndong
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Katsumata
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
authors.forename: Mariko
authors.initials: M
authors.lastname: Uehara
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001343:Autophagy / Q000187:drug effects; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D000090463:Iron Deficiencies; D019266:Iron, Dietary / Q000008:administration & dosage*; D000072019:Kelch-Like ECH-Associated Protein 1; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D051267:NF-E2-Related Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D018384:Oxidative Stress / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000975:Antioxidants; D003598:Cytoskeletal Proteins; D019266:Iron, Dietary; C117301:Keap1 protein, mouse; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; C495636:Nfe2l2 protein, mouse; D051547:Heme Oxygenase-1; D013482:Superoxide Dismutase
keywords: antioxidant enzyme; autophagy; heart; iron deficiency; oxidative stress