title: Genetic association between leptin-2548G/A polymorphism and risk of cancer: a meta analysis.
abstract: OBJECTIVE
  Abundance of evidence implicated that leptin may play a decisive role in cancer occurrence, but the reported results varied across the individually published studies. The objective of this study is to access to what extent the extensively studied -2548G/A polymorphism of LEP gene acts on the onset of multiple cancers.
  
  
  METHODS
  Eligible studies included in this meta-analysis were identified electronically in PubMed and Embase, and manually in relevant literature. Crude odds ratio (OR) with corresponding 95% confidence interval (CI) was calculated to estimate the risk of cancer associated with the -2548G/A polymorphism.
  
  
  RESULTS
  12 association studies with a total of 5,618 cancer cases and 6,509 healthy controls were pooled into this meta-analysis. The results revealed that compared with the G allele, the A allele was associated with modestly increased risk of overall cancer (OR, 1.21; 95% CI, 1.02-1.44). Following further stratified analyses, a borderline association was indicated in prostate cancer (OR, 1.18; 95% CI, 1.00-1.39), breast cancer (OR, 1.11; 95% CI, 1.00-1.22) and Caucasians (OR, 1.19; 95% CI, 1.00-1.41).
  
  
  CONCLUSIONS
  This meta-analysis reveals that the A allele of -2548G/A polymorphism may be a determinant of cancer development.
authors.affiliation: Department of Orthopaedics, 401 Hospital of PLA Qingdao 266071, Shandong Province, China.
authors.forename: Yugang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Obstetrics And Gynecology, General Hospital of Bei Jing Command of PLA Beijing, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of General Surgery, 401 Hospital of PLA Qingdao 266071, Shandong Province, China.
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Oncology, 401 Hospital of PLA Qingdao 266071, Shandong Province, China.
authors.forename: Yunshu
authors.initials: Y
authors.lastname: Gao
keywords: Leptin; cancer; polymorphism; risk