title: Oral Secondary Syphilis.
abstract: Secondary syphilis develops in approximately 25% of patients infected with the spirochete bacterium Treponema pallidum. It typically develops several weeks to several months after the primary infection, which is recognized by a painless chancre. Secondary syphilis is characterized by systemic symptoms, such as malaise and fever as well as a maculopapular rash involving the trunk and extremities including the palms and soles. Condyloma lata, which are raised, fleshy lesions, tend to develop at the site of the primary chancre. Diagnosis is achieved primarily through screening and confirmational serologic testing. Histologic findings seen in condyloma lata are largely non-specific. Therefore, a high index of suspicion should be maintained and immunohistochemical stains specific for T. pallidum should be utilized.
authors.affiliation: Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA. peter.carbone@med.navy.mil.
authors.forename: Peter N
authors.initials: PN
authors.lastname: Carbone
authors.affiliation: Department of Otorhinolaryngology, Naval Medical Center San Diego, San Diego, CA, USA.
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Capra
authors.affiliation: Department of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Nelson
mesh_terms: D000328:Adult; D002601:Chancre / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D013587:Syphilis / Q000175:diagnosis* / Q000473:pathology
keywords: Condyloma lata; Immunohistochemical; Secondary syphilis; Treponema pallidum