title: The effect of Helicobacter pylori eradication therapy on the development of gastroesophageal reflux disease.
abstract: BACKGROUND
  It is uncertain whether the Helicobacter pylori eradication therapy makes a role in the progression of gastroesophageal reflux disease (GERD).
  
  
  METHODS
  A meta-analysis was undertaken to investigate the effect of H pylori eradication therapy on the development of GERD.
  
  
  RESULTS
  Overall, 16 cohort studies were included. The authors demonstrated that H pylori eradication had no significant effect on the occurrence of GERD in these cohort studies (odds ratio = 0.87, 95% confidence interval = 0.66-1.14, I = 32.4%, P = 0.103).
  
  
  CONCLUSIONS
  In general, H pylori eradication has no significant effect on the development of GERD in the long term. However, eradication therapy should be taken once there is H pylori infection, because H pylori infection is acknowledged to be a major cause of acute and chronic gastritis and peptic ulcer diseases and has been established as a definite etiologic factor for gastric cancer.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Jiacheng
authors.initials: J
authors.lastname: Tan
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Sun
authors.forename: Wenxia
authors.initials: W
authors.lastname: Cui
authors.forename: Jianchao
authors.initials: J
authors.lastname: Ge
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
mesh_terms: D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000517:prevention & control; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans