title: Pathogenesis, clinical course and neuro-radiological signs of Proprionibacterium acnes cerebritis: Case report and literature review.
abstract: The clinical and neuroimaging characteristics of brain infections related to Propionibacterium acnes are not well-characterized, making early diagnosis and treatment a challenge. More recently, life-threatening central nervous system infections with P. acnes are being reported with increasing frequency as complications of neurointerventional procedures. We present a rare case of P. acnes cerebritis that occurred as a sequela of bare platinum aneurysm coiling and a contaminant of percutaneous angiographic intervention. We include an extensive review of the literature describing the pathogenesis of P. acnes and neuro-radiological signs of brain infections related to this pathogen.
authors.affiliation: University of South Florida Morsani College of Medicine - SELECT Program , Allentown, PA , USA.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Yakhkind
authors.forename: Hussam A
authors.initials: HA
authors.lastname: Yacoub
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Grove
authors.forename: Jay D
authors.initials: JD
authors.lastname: Varrato
authors.forename: John E
authors.initials: JE
authors.lastname: Castaldo
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008875:Middle Aged; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents
keywords: Brain infection; Propionibacterium acnes; brain MRI; cerebritis