title: STEP levels are unchanged in pre-frontal cortex and associative striatum in post-mortem human brain samples from subjects with schizophrenia, bipolar disorder and major depressive disorder.
abstract: Increased protein levels of striatal-enriched tyrosine phosphatase (STEP) have recently been reported in postmortem schizophrenic cortex. The present study sought to replicate this finding in a separate cohort of postmortem samples and to extend observations to striatum, including subjects with bipolar disorder and major depressive disorder in the analysis. No statistically significant changes between disease and control subjects were found in STEP mRNA or protein levels in dorsolateral prefrontal cortex or associative striatum. Although samples were matched for several covariates, postmortem interval correlated negatively with STEP protein levels, emphasizing the importance of including these analyses in postmortem studies.
authors.affiliation: Pfizer Research & Development, Cambridge, MA, United States of America.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Lanz
authors.affiliation: Pfizer Research & Development, Cambridge, MA, United States of America.
authors.forename: J Julie
authors.initials: JJ
authors.lastname: Joshi
authors.affiliation: Pfizer Research & Development, Cambridge, MA, United States of America.
authors.forename: Veronica
authors.initials: V
authors.lastname: Reinhart
authors.affiliation: Arbor Analytics, Ann Arbor, MI, United States of America.
authors.forename: Kjell
authors.initials: K
authors.lastname: Johnson
authors.affiliation: Arbor Analytics, Ann Arbor, MI, United States of America.
authors.forename: Lonnie E
authors.initials: LE
authors.lastname: Grantham
authors.affiliation: Pfizer Research & Development, Cambridge, MA, United States of America.
authors.forename: Dmitri
authors.initials: D
authors.lastname: Volfson
mesh_terms: D001344:Autopsy; D001714:Bipolar Disorder / Q000201:enzymology* / Q000235:genetics; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000201:enzymology* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017072:Neostriatum / Q000201:enzymology*; D017397:Prefrontal Cortex / Q000201:enzymology*; D054558:Protein Tyrosine Phosphatases, Non-Receptor / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C489930:PTPN5 protein, human; D054558:Protein Tyrosine Phosphatases, Non-Receptor