title: Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.
abstract: In the hippocampus of mice lacking the gene for serine racemase (SR), a D-serine synthesizing enzyme, in the CaMKIIα-expressing neurons, we observed a significant decrease in the extracellular concentration of D-serine, a coagonist for the N-methyl-D-aspartate type glutamate receptor (NMDAR), and NMDAR hypofunction as revealed by diminished extracellular taurine concentrations after an intra-hippocampal NMDA infusion when compared to the wild type controls. Therefore, the neuronal SR could regulate the extracellular D-serine signaling responsible for NMDAR activation in the hippocampus.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
authors.forename: Sayuri
authors.initials: S
authors.lastname: Ishiwata
authors.forename: Asami
authors.initials: A
authors.lastname: Umino
authors.forename: Darrick T
authors.initials: DT
authors.lastname: Balu
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Coyle
authors.forename: Toru
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D018345:Mice, Knockout; D017551:Microdialysis; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000378:metabolism; D009474:Neurons / Q000201:enzymology*; D019998:Racemases and Epimerases / Q000235:genetics / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism; D000099300:Serine Racemase
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D018698:Glutamic Acid; D005998:Glycine; D016202:N-Methylaspartate; D019998:Racemases and Epimerases; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; D013654:Taurine; D000099300:Serine Racemase; C517671:Camk2a protein, mouse