title: Enteral topiramate in a pediatric patient with refractory status epilepticus: a case report and review of the literature.
abstract: We describe the use of topiramate in a healthy 12-year-old (88-kg) male who developed refractory generalized convulsive status epilepticus. Seizures persisted despite aggressive use of benzodiazepines (intravenous lorazepam; oral clorazepate), barbiturates (i.e., phenobarbital, pentobarbital), and hydantoins. The child's seizures were controlled with nasogastrically administered topiramate in doses up to 500 mg twice daily (11.4 mg/kg/day). The patient did not display any clinical or laboratory signs of metabolic acidosis while receiving topiramate. Topiramate should be considered as a treatment option in refractory status epilepticus.
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee.
authors.forename: Chasity M
authors.initials: CM
authors.lastname: Shelton
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee.
authors.forename: Elizabeth L
authors.initials: EL
authors.lastname: Alford
authors.affiliation: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Storgion
authors.affiliation: Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee ; Neuroscience Institute and Le Bonheur Comprehensive Epilepsy Program, Le Bonheur Children's Hospital, Memphis, Tennessee.
authors.forename: James
authors.initials: J
authors.lastname: Wheless
authors.affiliation: Department of Clinical Pharmacy, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, Tennessee ; Department of Pediatrics, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Phelps
keywords: epilepsy; pediatric; refractory status epilepticus; topiramate; treatment