title: Striatal blood-brain barrier permeability in Parkinson's disease.
abstract: In vivo studies have shown that blood-brain barrier (BBB) dysfunction is involved in the course of Parkinson's disease (PD). However, these have lacked either anatomic definition or the ability to recognize minute changes in BBB integrity. Here, using histologic markers of serum protein, iron, and erythrocyte extravasation, we have shown significantly increased permeability of the BBB in the postcommissural putamen of PD patients. The dense innervation of the striatum by PD-affected regions allows for exploitation of this permeability for therapeutic goals. These results are also discussed in the context of the retrograde trans-synaptic hypothesis of PD spread.
authors.affiliation: 1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
authors.forename: Madison T
authors.initials: MT
authors.lastname: Gray
authors.affiliation: 1] Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada [2] Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada [3] Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
authors.forename: John M
authors.initials: JM
authors.lastname: Woulfe
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000378:metabolism* / Q000473:pathology*; D002199:Capillary Permeability; D004912:Erythrocytes / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D007501:Iron