title: Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity.
abstract: A novel in vitro onychomycosis model was developed to easily predict the topical activity potential of novel antifungal drugs. The model encompasses drug activity and diffusion through bovine hoof slices in a single experimental set-up. Results correspond well with the antifungal susceptibility assay and Franz cell diffusion test.
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Reindert
authors.initials: R
authors.lastname: Sleven
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Ellen
authors.initials: E
authors.lastname: Lanckacker
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Boulet
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Peter
authors.initials: P
authors.lastname: Delputte
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
authors.forename: Louis
authors.initials: L
authors.lastname: Maes
authors.affiliation: Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. Electronic address: paul.cos@uantwerpen.be.
authors.forename: Paul
authors.initials: P
authors.lastname: Cos
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics / Q000494:pharmacology*; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002417:Cattle; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006724:Hoof and Claw / Q000187:drug effects / Q000382:microbiology; D008962:Models, Theoretical; D014009:Onychomycosis / Q000188:drug therapy*
chemical_list: D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents
keywords: Drug evaluation; Onychomycosis; Topical antifungals