title: The role of miR-29b in cancer: regulation, function, and signaling.
abstract: MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b, and miR-29c, among which miR-29b is the most highly expressed and is found at two genomic loci. Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain conditions. In this review, we illustrate the role of miR-29b in cancer regulation, function, and signaling. This is the first review highlighting the role of miR-29b in cancer. Our review aims to summarize the effects of miR-29b on cancer activity and its interactions with target genes and signaling pathways, as well as to provide therapeutic implications for overcoming cancer chemoresistance.
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yan
authors.affiliation: Department of Urology, The Central Hospital of Changsha, Changsha, People's Republic of China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Urology, The Central Hospital of Changsha, Changsha, People's Republic of China.
authors.forename: Fa-Jun
authors.initials: FJ
authors.lastname: Fu
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yin
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Yong-Bao
authors.initials: YB
authors.lastname: Wei
authors.affiliation: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Jin-Rui
authors.initials: JR
authors.lastname: Yang
keywords: biological function; cancer; chemoresistance; miR-29b; oncogene; tumor promoter