title: Quaternary polymethacrylate-sodium alginate films: effect of alginate block structures and use for sustained release tablets.
abstract: The objectives in this study were to characterize quaternary polymethacrylate-sodium alginate (QPM-SA) films prepared using high G block or high M block SA (GSA or MSA, respectively), and to investigate the effects of QPM-SA ratios, film-coating levels and SA block structures on propranolol HCl (PPN) released from coated tablets. The results demonstrated that GSA and MSA shared a similar interaction mechanism with QPM. The QPM-GSA films had higher puncture strength than the QPM-MSA films in dry and wet states, whereas the % elongations were not different. The drug permeability of the QPM-GSA films was lower than that of the QPM-MSA films in both acidic and neutral media, but higher water uptake of the QPM-GSA films was found at neutral pH. Moreover, the QPM-MSA-coated tablets had a greater PPN release rate than the QPM-GSA-coated tablets, and drug release was dependent on the film-coating levels. In addition, the QPM-SA films at a ratio of 4:0.5 produced a stronger film and could sustain PPN release. These results indicate that the QPM-GSA films had greater film strength and lower drug permeability than the QPM-MSA films. Additionally, the QPM-SA films have a strong potential for use in sustained-release tablets.
authors.affiliation: a Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Thaned
authors.initials: T
authors.lastname: Pongjanyakul
authors.affiliation: a Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand.
authors.forename: Natnicha
authors.initials: N
authors.lastname: Khuathan
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D065546:Drug Liberation; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D010539:Permeability; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011433:Propranolol / Q000008:administration & dosage* / Q000737:chemistry; D013607:Tablets
chemical_list: D000464:Alginates; D000889:Anti-Arrhythmia Agents; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D011109:Polymethacrylic Acids; D013607:Tablets; C030613:polymethacrylic acid; D020723:Glucuronic Acid; D011433:Propranolol
keywords: Block structure; drug release; film coating; quaternary polymethacrylate; sodium alginate