title: [Microalbuminurea as an early indicator of renal lesion in arterial hypertension].
abstract: Arterial hypertension (AH) is undoubtedly associated with progressive renal dysfunction. Microalbminuria (MAU) is a reliable indicator of the early stage of renal disease and predictor of AH progress as well as an independent risk factor of cardiovascular mortality and death. The main pathophysiological mechanisms of MAU in AH are enhanced glomerular hydrostatic pressure, structural changes and endothelial dysfunction in glomerular capillaries. Also, an important role is played by AH-related progressive chronic preclinical inflammation as appears from positive correlation between MAU and CRP, fibrinogen, and cytokines. It is concluded that evaluation of MAU as an indicator of cardiovascular risk needs to be widely used in clinical practice for the improvement of AH treatment and the reduction of probability of complications.
authors.forename: P A
authors.initials: PA
authors.lastname: Zelveian
authors.forename: L G
authors.initials: LG
authors.lastname: Dgerian
mesh_terms: D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D019468:Disease Management; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D007004:Hypoglycemic Agents