title: [Acquired coagulant factor inhibitors].
abstract: Acquired coagulation factor inhibitors are an autoimmune disease causing bleeding symptoms due to decreases in the corresponding factor (s) which result from the appearance of autoantibodies against coagulation factors (inhibitor). This disease is quite different from congenital coagulation factor deficiencies based on genetic abnormalities. In recent years, cases with this disease have been increasing, and most have anti-factor VIII autoantibodies. The breakdown of the immune control mechanism is speculated to cause this disease since it is common in the elderly, but the pathology and pathogenesis are presently unclear. We herein describe the pathology and pathogenesis of factor VIII and factor V inhibitors. Characterization of these inhibitors leads to further analysis of the coagulation process and the activation mechanisms of clotting factors. In the future, with the development of new clotting examination method (s), we anticipate that further novel findings will be obtained in this field through inhibitor analysis. In addition, detailed elucidation of the coagulation inhibitory mechanism possibly leading to hemostatic treatment strategies for acquired coagulation factor disorders will be developed.
authors.affiliation: Pediatrics, Nara Medical University.
authors.forename: Keiji
authors.initials: K
authors.lastname: Nogami
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000276:immunology / Q000502:physiology*; D001778:Blood Coagulation Disorders / Q000188:drug therapy*; D001779:Blood Coagulation Factors / Q000276:immunology; D003029:Coagulants / Q000627:therapeutic use*; D005169:Factor VIII / Q000627:therapeutic use; D006490:Hemostatics / Q000378:metabolism; D006801:Humans
chemical_list: D001779:Blood Coagulation Factors; D003029:Coagulants; D006490:Hemostatics; C427184:recombinant factor VIII SQ; D005169:Factor VIII