title: Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory.
abstract: Lymph nodes are highly organized secondary lymphoid structures crucial for the initiation of immune responses. Naive T cells are strategically located within lymph nodes to optimize their encounter with antigen-loaded dendritic cells. Recent advances in 3D lymph node imaging and tissue reconstruction along with methods for the detection of chemokine expression and gradients have highlighted how T cells position themselves during activation and memory responses. This article covers new insights into the guidance mechanisms that co-ordinate T-cell responses within draining lymph nodes. Furthering our understanding of how these pathways are regulated and promoted will lead to the exploitation of T-cell positioning to further strategize vaccine design.
authors.affiliation: 1] Immunology and Molecular Immunology Divisions, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Joanna R
authors.initials: JR
authors.lastname: Groom
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines
chemical_list: D014612:Vaccines