title: Association of annexin A2 with cancer development (Review).
abstract: Annexin A2 (ANXA2) is a well-known calcium-dependent phospholipid binding protein widely distributed in the nucleus, cytoplasm and extracellular surface of various eukaryotic cells. It has been recognized as a pleiotropic protein affecting a wide range of molecular and cellular processes. Dysregulation and abnormal expression of ANXA2 are linked to a large number of prevalent diseases, including autoimmune and neurodegenerative disease, antiphospholipid syndrome, inflammation, diabetes mellitus and a series of cancers. Accumulating data suggest that ANXA2 is aberrantly expressed in a wide spectrum of cancers, and exerts profound effects on tumor cell adhesion, proliferation, apoptosis, invasion and metastasis as well as tumor neovascularization via different modes of action. However, despite significant research, our knowledge of the mechanism by which ANXA2 participates in cancer development remains fragmented. The present review systematically summarizes the effects of ANXA2 on tumor progression, in an attempt to gain an improved understanding of the underlying mechanisms and to provide a potential effective target for cancer therapy.
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Xiao-Heng
authors.initials: XH
authors.lastname: Xu
authors.affiliation: Department of Pediatrics, The Second Hospital of Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Kang
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Feng
authors.affiliation: Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, P.R. China.
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Song
mesh_terms: D017306:Annexin A2 / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D017306:Annexin A2