title: Expression profiling of adult acute lymphoblastic leukemia identifies a BCR-ABL1-like subgroup characterized by high non-response and relapse rates.
authors.affiliation: Laboratory of Pediatric Oncology/Hematology, Erasmus MC -Sophia Children's Hospital, Rotterdam, the Netherlands.
authors.forename: Judith M
authors.initials: JM
authors.lastname: Boer
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Jasper E
authors.initials: JE
authors.lastname: Koenders
authors.affiliation: HOVON Data Center, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Bronno
authors.initials: B
authors.lastname: van der Holt
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Carla
authors.initials: C
authors.lastname: Exalto
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Mathijs A
authors.initials: MA
authors.lastname: Sanders
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Cornelissen
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands.
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Valk
authors.affiliation: Laboratory of Pediatric Oncology/Hematology, Erasmus MC -Sophia Children's Hospital, Rotterdam, the Netherlands m.l.denboer@erasmusmc.nl a.rijneveld@erasmusmc.nl.
authors.forename: Monique L
authors.initials: ML
authors.lastname: den Boer
authors.affiliation: Department of Hematology, Erasmus MC, Erasmus MC Cancer Institute, Clinical Trial Center, Rotterdam, the Netherlands m.l.denboer@erasmusmc.nl a.rijneveld@erasmusmc.nl.
authors.forename: Anita W
authors.initials: AW
authors.lastname: Rijneveld
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D018380:Hematopoietic Stem Cell Transplantation; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics / Q000378:metabolism; D000068877:Imatinib Mesylate / Q000627:therapeutic use*; D008875:Middle Aged; D009154:Mutation; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction; D016019:Survival Analysis; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents; C581634:BCR-ABL1 fusion protein, human; C497239:IKZF1 protein, human; C497422:KMT2A protein, human; D047428:Protein Kinase Inhibitors; D051740:Ikaros Transcription Factor; D051788:Myeloid-Lymphoid Leukemia Protein; D000068877:Imatinib Mesylate; D011495:Histone-Lysine N-Methyltransferase; D016044:Fusion Proteins, bcr-abl
keywords: B-cell precursor acute lymphoblastic leukemia; BCR-ABL-like acute lymphoblastic leukemia; expression profiling; outcome