title: A broken krebs cycle in macrophages.
abstract: Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.
authors.affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address: laoneill@tcd.ie.
authors.forename: Luke A J
authors.initials: LA
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks / Q000276:immunology*; D007113:Immunity, Innate; D008264:Macrophages / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D014158:Transcription, Genetic / Q000276:immunology*