title: A Case of Cellular Fibrous Histiocytoma on the Right Elbow with Repeated Relapse within a Short Period.
abstract: Cellular fibrous histiocytoma, a variant of fibrous histiocytoma, is a designation used for lesions showing increased cellularity with a fascicular growth pattern and frequent extension into the subcutis. Here we describe a case of cellular fibrous histiocytoma showing repeated recurrence in a 36-year-old woman who initially presented with a 2-cm cutaneous tumor on her right elbow. Histopathologically, the first resected specimen demonstrated irregularly arranged collagen fibers mixed with scattered proliferating plump to spindle-shaped fibrohistiocytes. However, examination of the resected specimens obtained after recurrence showed that the cellularity had increased, the spindle-shaped cells showing monomorphic proliferation with a fascicular and storiform growth pattern extending into the subcutis, as well as an increase of Ki-67 positivity. Since the lesion showed repeated relapse within a short period, we performed wide-field resection of the tumor with a 3-cm margin. Currently, 48 months after surgery, there has been no local recurrence or metastasis, but continuous strict follow-up will be necessary.
authors.affiliation: Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Tsunoda
authors.affiliation: Department of Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Oikawa
authors.affiliation: Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Maeda
authors.affiliation: Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Dermatology, School of Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Akasaka
keywords: CD163; CD34; CD44; Cellular fibrous histiocytoma; Dermatofibrosarcoma protuberans; Factor XIIIa