title: Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects.
abstract: The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Chen
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China. Electronic address: suyanggo@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Su
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China.
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, 150040 Harbin, China. Electronic address: hxkuang@hotmail.com.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D000818:Animals; D031885:Cimicifuga / Q000737:chemistry*; D006801:Humans; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010840:Phytosterols; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C100089:cycloartenol
keywords: Biological effects; Cimicifuga simplex; Cycloartenol triterpenoid saponins; Ranunculaceae