title: Fibrillarin from Archaea to human.
abstract: Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negative regulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
authors.affiliation: Unidad de Bioquímica y Biología molecular de plantas, Centro de Investigación Científica de Yucatán, Colonia Chuburná de Hidalgo, Mérida, Yucatan, Mexico.
authors.forename: Ulises
authors.initials: U
authors.lastname: Rodriguez-Corona
authors.affiliation: Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic.
authors.forename: Margarita
authors.initials: M
authors.lastname: Sobol
authors.affiliation: Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Colonia Chuburná de Hidalgo, Mérida, Yucatan, Mexico.
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Rodriguez-Zapata
authors.affiliation: Department of Biology of the Cell Nucleus, Institute of Molecular Genetics of the Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Hozak
authors.affiliation: Unidad de Bioquímica y Biología molecular de plantas, Centro de Investigación Científica de Yucatán, Colonia Chuburná de Hidalgo, Mérida, Yucatan, Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Castano
mesh_terms: D000818:Animals; D001105:Archaea / Q000235:genetics* / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism
chemical_list: D002868:Chromosomal Proteins, Non-Histone; C047458:fibrillarin
keywords: Cancer; Methylation; RNA processing; Ribosomal biogenesis; p53