title: Metabolic pathways promoting cancer cell survival and growth.
abstract: Activation of oncogenes and loss of tumour suppressors promote metabolic reprogramming in cancer, resulting in enhanced nutrient uptake to supply energetic and biosynthetic pathways. However, nutrient limitations within solid tumours may require that malignant cells exhibit metabolic flexibility to sustain growth and survival. Here, we highlight these adaptive mechanisms and also discuss emerging approaches to probe tumour metabolism in vivo and their potential to expand the metabolic repertoire of malignant cells even further.
authors.affiliation: Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA.
authors.forename: Lindsey K
authors.initials: LK
authors.lastname: Boroughs
authors.affiliation: 1] Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [2] Department of Pediatrics University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA [3] McDermott Center for Human Growth and Development University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390-8502, USA.
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: DeBerardinis
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000378:metabolism*; D009857:Oncogenes
chemical_list: D005947:Glucose