title: Health status and quality of life in patients with psoriasis: an Iranian cross-sectional survey.
abstract: BACKGROUND
  Psoriasis has a significant negative impact on patients' health-related quality of life (HRQOL). This study aims to evaluate HRQOL of adult patients with psoriasis in Iran, and explore the relationship between general and disease-specific outcome measures in psoriasis.
  
  
  METHODS
  Between May and August 2013, a cross-sectional questionnaire survey of consecutive outpatients was conducted at a single clinic in Shiraz, Iran. HRQOL was assessed by the general measure EuroQol 5 dimensions (EQ-5D), visual analogue scale (EQ VAS), and the disease-specific Dermatology Life Quality Index (DLQI). Disease severity was measured by the Psoriasis Area and Severity Index (PASI).
  
  
  RESULTS
  Sixty-two patients (76% males) completed the questionnaire with a mean age (SD) of 40.4 (17.5) years. Overall, 39% of the patients used only topical and 48% received systemic non-biological therapy in the past 12 months. Median EQ-5D, EQ VAS, DLQI and PASI scores were 0.73, 60, 8 and 11.75, respectively. Out of the 62 patients, 18%, 26%, 28%, 63%, and 63% reported some or severe problem in mobility, self-care, usual activities, pain/discomfort and anxiety/depression, respectively. EQ-5D and EQ VAS correlated moderately with DLQI (rs = -0.44 for both, p < 0.001), but only EQ VAS correlated significantly with PASI (rs = -0.31, p < 0.01).
  
  
  CONCLUSIONS
  This is the first study from Iran that assesses HRQOL in adult patients with psoriasis by EQ-5D and EQ VAS. Reduction in general HRQOL measured with EQ-5D and EQ-VAS is considerable, mostly in anxiety/depression and pain/discomfort dimensions. EQ-5D scores evaluated in this study provide country-specific data for economic evaluations.
authors.affiliation: Corvinus University of Budapest, Department of Health Economics, H-1093 Fővám tér 8, Budapest, Hungary. valentin.brodszky@uni-corvinus.hu.
authors.forename: Mahshid
authors.initials: M
authors.lastname: Moradi
authors.affiliation: Corvinus University of Budapest, Department of Health Economics, H-1093 Fővám tér 8, Budapest, Hungary, Doctoral School of Clinical Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Fanni
authors.initials: F
authors.lastname: Rencz
authors.affiliation: Corvinus University of Budapest, Department of Health Economics, H-1093 Fővám tér 8, Budapest, Hungary.
authors.forename: Valentin
authors.initials: V
authors.lastname: Brodszky
authors.affiliation: Moradi Skin Laser Clinic, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Moradi
authors.affiliation: Corvinus University of Budapest, Department of Health Economics, H-1093 Fővám tér 8, Budapest, Hungary.
authors.forename: Orsolya
authors.initials: O
authors.lastname: Balogh
authors.affiliation: Corvinus University of Budapest, Department of Health Economics, H-1093 Fővám tér 8, Budapest, Hungary.
authors.forename: László
authors.initials: L
authors.lastname: Gulácsi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011565:Psoriasis / Q000523:psychology*; D011788:Quality of Life