title: Selective (bio)functionalization of solid-state nanopores.
abstract: We present a method to selectively (bio)functionalize nanoscale features with the same materials chemistry. It was successfully combined with nanosphere lithography to fabricate and functionalize solid-state nanopores with PEG-brushes, supported lipid membranes, and functional proteins over large areas. The method is inexpensive, can be performed without specialized equipment, and can be applied to both topographic and planar surface modification.
authors.affiliation: †Department of Materials, ETH Zurich, CH-8093 Zurich, Switzerland.
authors.forename: Mateu
authors.initials: M
authors.lastname: Pla-Roca
authors.affiliation: †Department of Materials, ETH Zurich, CH-8093 Zurich, Switzerland.
authors.forename: Lucio
authors.initials: L
authors.lastname: Isa
authors.affiliation: †Department of Materials, ETH Zurich, CH-8093 Zurich, Switzerland.
authors.forename: Karthik
authors.initials: K
authors.lastname: Kumar
authors.affiliation: †Department of Materials, ETH Zurich, CH-8093 Zurich, Switzerland.|∥Department of Nanobiotechnology, University of Natural Resources and Life Sciences Vienna, 1190 Vienna, Austria.
authors.forename: Erik
authors.initials: E
authors.lastname: Reimhult
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D008051:Lipid Bilayers / Q000737:chemistry*; D008422:Materials Testing; D008565:Membrane Proteins / Q000737:chemistry*; D058726:Nanoconjugates / Q000737:chemistry* / Q000648:ultrastructure*; D058608:Nanopores / Q000648:ultrastructure*; D013499:Surface Properties
chemical_list: D001704:Biopolymers; D008051:Lipid Bilayers; D008565:Membrane Proteins; D058726:Nanoconjugates
keywords: PEG brush; nanopore functionalization; nanosphere lithography; solid state nanopore; supported lipid bilayer