title: Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis.
abstract: OBJECTIVE
  We aimed to clarify the influences of aldehyde dehydrogenase 2 (ALDH2), alcohol dehydrogenase 1B (ADH1B) polymorphisms, and ethanol consumption profile to hepatocellular carcinoma (HCC) development in alcoholic liver cirrhosis without chronic hepatitis B and C virus infection (non-B non-C).
  
  
  METHODS
  Of 236 freshly diagnosed non-B non-C alcoholic liver cirrhosis patients, 67 were diagnosed as HCC and the remaining 169 as not having HCC. The relationship between the genetic polymorphisms and development to HCC were evaluated in well-matched patients with HCC (HCC group, n = 67) and without HCC (non-HCC group, n = 67) using propensity scores in age, sex, and prevalence of diabetes mellitus.
  
  
  RESULTS
  Daily amount of ethanol consumption was significantly lower (P = 0.005), and consumptive period was significantly longer (P = 0.003) in HCC group than non-HCC group. Of 134 well-matched patients, 113 (84.3%) had ALDH2*1/*1 genotype and 21 (15.7%) had ALDH2*1/*2 genotype. In HCC development, consumptive long period (P = 0.007) and carrying ALDH2*1/*2 genotype (P = 0.026) were identified as significant factors independently participated, while there was no relation to ADH1B polymorphism. In addition, consumptive period was significantly longer in HCC group than non-HCC group in ALDH2*1/*1 genotype patients (P = 0.0005), while there was no difference in profile of ethanol consumption in ALDH2*1/*2 genotype patients. Among HCC group, daily (P = 3.78 × 10(-6) ) and cumulative amount (P = 4.89 × 10(-6) ) of ethanol consumption were significantly higher in ALDH2*1/*1 genotype patients than ALDH2*1/*2 genotype patients.
  
  
  CONCLUSIONS
  In alcoholic liver cirrhosis, investigations of ALDH2 polymorphism and ethanol consumption profile are useful for prediction of HCC development.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Abe
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Aida
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Seki
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Sugita
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tomita
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Nagano
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Munenori
authors.initials: M
authors.lastname: Itagaki
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sutoh
authors.affiliation: The Jikei University School of Medicine, Kashiwa, Chiba, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nagatsuma
authors.affiliation: Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Chiba, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Itoh
authors.affiliation: Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Chiba, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Matsuura
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine Katsushika Medical Center, Tokyo, Chiba, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000426:Alcohol Dehydrogenase / Q000235:genetics; D000428:Alcohol Drinking / Q000009:adverse effects / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004365:Drugs, Chinese Herbal; D028001:Eleutherococcus; D005202:Asia, Eastern / Q000453:epidemiology; D005260:Female; D005544:Forecasting; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000209:etiology / Q000235:genetics*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D004365:Drugs, Chinese Herbal; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; C400150:Acanthopanax gracilistylus, extract
keywords: alcohol dehydrogenase 1B polymorphism; alcoholic liver cirrhosis; aldehyde dehydrogenase 2 polymorphism; consumptive period; cumulative amount of ethanol consumption; daily amount of ethanol consumption; hepatocellular carcinoma