title: Association of Serum Heavy Metals and Trace Element Concentrations with Reproductive Hormone Levels and Polycystic Ovary Syndrome in a Chinese Population.
abstract: To investigate the serum concentrations of 11 heavy metals and trace elements in patients with polycystic ovary syndrome (PCOS). A total of 369 women (including 96 patients with PCOS) were studied. No differences with statistical significance in the median barium, cadmium, lead, arsenic, chromium, gallium, strontium, and vanadium concentrations were observed between the patients with PCOS and the control group. Serum nickel (Ni) (P = 0.000) and copper (Cu) (P = 0.000) levels were significantly higher, but zinc (Zn) levels (P = 0.009) were significantly lower in patients with PCOS compared with the control group. The results of the association between metal levels and hormone levels indicated that Ni, Cu, and Zn may play a role in the pathogenesis of PCOS related with reproductive hormone levels. The findings in the present study should be investigated with further trials in order to obtain new insights into PCOS.
authors.affiliation: State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China.
authors.forename: Guanchao
authors.initials: G
authors.lastname: Zheng
authors.forename: Lijun
authors.initials: L
authors.lastname: Wang
authors.forename: Zhizhun
authors.initials: Z
authors.lastname: Guo
authors.forename: Lingbin
authors.initials: L
authors.lastname: Sun
authors.forename: Lingling
authors.initials: L
authors.lastname: Wang
authors.forename: Chonggang
authors.initials: C
authors.lastname: Wang
authors.forename: Zhenghong
authors.initials: Z
authors.lastname: Zuo
authors.forename: Huiling
authors.initials: H
authors.lastname: Qiu
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China; D003300:Copper / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D016014:Linear Models; D007986:Luteinizing Hormone / Q000097:blood; D019216:Metals, Heavy / Q000097:blood*; D009532:Nickel / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000208:ethnology; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
chemical_list: D006728:Hormones; D019216:Metals, Heavy; D014131:Trace Elements; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D003300:Copper; D009532:Nickel; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015032:Zinc