title: Aging induced cortical drive alterations during sleep in rats.
abstract: We followed the impact of healthy aging on cortical drive during sleep in rats by using the corticomuscular coherence (CMC). We employed the chronic electrodes implantation for sleep recording in adult, male Wistar rats, and followed the aging impact during sleep from 3 to 5.5 months age. We have analyzed the sleep/wake states architecture, and the sleep/wake state related EEG microstructure and CMCs. We evidenced the topographically distinct impact of aging on sleep/wake states architecture within the sensorimotor (SMCx) vs. motor cortex (MCx) from 4.5 to 5.5 months age. Healthy aging consistently altered only the SMCx sleep/wake states architecture, and increased the delta and beta CMCs through both cortical drives during Wake, but only through the MCx drive during REM. According to the delta and beta CMCs values, aging impact through the SMCx drive was opposite, but it was convergent through the MCx drive during Wake vs. REM, and there was a dual and inverse mode for the motor control during REM.
authors.affiliation: University of Belgrade, Department of Neurobiology, Institute for Biological Research - Sinisa Stankovic, 11 060 Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Ciric
authors.affiliation: University of Belgrade, Department of Neurobiology, Institute for Biological Research - Sinisa Stankovic, 11 060 Belgrade, Serbia.
authors.forename: Katarina
authors.initials: K
authors.lastname: Lazic
authors.affiliation: University of Belgrade, Department of Neurobiology, Institute for Biological Research - Sinisa Stankovic, 11 060 Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Petrovic
authors.affiliation: University of Belgrade, Department for Life Sciences, Institute for Multidisciplinary Research, 11 030 Belgrade, Serbia.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kalauzi
authors.affiliation: University of Belgrade, Department of Neurobiology, Institute for Biological Research - Sinisa Stankovic, 11 060 Belgrade, Serbia. Electronic address: jasnasap@ibiss.bg.ac.rs.
authors.forename: Jasna
authors.initials: J
authors.lastname: Saponjic
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D066191:Sensorimotor Cortex / Q000502:physiology*; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology
keywords: Aging; Cortical drive; Corticomuscular coherence; EEG; EMG; Sleep