title: Weaning gives β cells license to regenerate.
abstract: Pancreatic beta cell proliferation is high at birth and then rapidly declines. In this issue of Developmental Cell,Stolovich-Rain et al. (2015) show that β cells' capacity to increase proliferation in response to injury is unexpectedly not acquired until after weaning-related nutritional changes trigger a metabolic and regenerative competence program.
authors.affiliation: Genomic Programming of Beta-Cells Laboratory, Institut d'Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain. Electronic address: merovira@clinic.ub.es.
authors.forename: Meritxell
authors.initials: M
authors.lastname: Rovira
authors.affiliation: Genomic Programming of Beta-Cells Laboratory, Institut d'Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain; Department of Medicine, Imperial College London, London W12 0NN, UK. Electronic address: j.ferrer@imperial.ac.uk.
authors.forename: Jorge
authors.initials: J
authors.lastname: Ferrer
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000166:cytology*; D008297:Male; D014886:Weaning
chemical_list: D015415:Biomarkers; D007328:Insulin; D005947:Glucose