title: Serum fibroblast growth factor 21 levels are increased in atrial fibrillation patients.
abstract: BACKGROUND
  Fibroblast growth factor 21 (FGF-21), a newly discovered adipokine, plays an important role in glucose and lipid metabolism and is associated with the development of metabolic disorders, such as obesity, and cardiovascular diseases. This study aimed to investigate the association of serum FGF-21 levels with the presence of atrial fibrillation (AF).
  
  
  METHODS
  Total 113 patients with AF and 60 healthy control subjects were enrolled. All AF cases were categorized into paroxysmal, persistent and permanent AF. Serum levels of FGF-21, high-sensitivity C-reactive protein (hs-CRP) and other routine biochemical parameters were measured.
  
  
  RESULTS
  Serum FGF-21 levels were significantly higher in AF patients than in controls (250.12±78.48 vs. 144.15±56.31pg/mL, P<0.001), and hs-CRP levels were significantly higher in AF patients than in controls (2.36±1.10 vs. 1.24±0.82, P<0.05). In subgroup studies, patients with permanent AF had higher serum FGF-21 levels than those with persistent and paroxysmal AF. After the adjustment of the age, gender and body mass index, serum FGF-21 levels were positively correlated with left atrial diameter (LAD) (P<0.01). A multivariate logistic regression analysis showed that FGF-21, LAD and hs-CRP were correlated with AF (P<0.05).
  
  
  CONCLUSIONS
  Our data demonstrate that serum FGF-21 levels are elevated in AF patients and associated with atrial remolding, independent of established risk factors such as C-reactive protein.
authors.affiliation: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
authors.forename: Xinyuan
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of Medical School, Xi'an Jiaotong University, China; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
authors.forename: Gong
authors.initials: G
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Xie
authors.affiliation: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
authors.forename: Xiling
authors.initials: X
authors.lastname: Shou
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of Medical School, Xi'an Jiaotong University, China. Electronic address: cfsun1@126.com.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Sun
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: Adipokine; Atrial fibrillation; Fibroblast growth factor 21; Obesity