title: Oncological outcome after radical prostatectomy: Marital status does not make a difference.
abstract: OBJECTIVE
  To examine the impact of marital status on prostate cancer characteristics at radical prostatectomy and oncological outcome after surgery at a high-volume center.
  
  
  METHODS
  We relied on the Martini-Clinic Prostate Cancer database and investigated 8088 prostate cancer patients treated with radical prostatectomy between January 2000 and March 2011. We analyzed differences in clinical and pathological characteristics according to marital status (married and partnership vs single). Additionally, we relied on multivariable Cox regression analyses to predict biochemical recurrence, metastases and death after radical prostatectomy. Finally, Kaplan-Meier analyses were used in a propensity score-matched cohort, adjusted for clinical and pathological characteristics, to examine differences in biochemical recurrence-free, metastases-free and overall survival according to marital status.
  
  
  RESULTS
  According to marital status, no significant differences were recorded within clinical and pathological characteristics (all P > 0.05). The impact of marital status on biochemical recurrence (hazard ratio 1.0, 95% confidence interval 0.9-1.3, P = 0.7), metastases (hazard ratio 1.3, 95% confidence interval 0.8-2.1, P = 0.3) and death (hazard ratio 0.8, 95% confidence interval 0.4-1.6, P = 0.6) after radical prostatectomy was not significant (median follow up 48 months). Kaplan-Meier analyses recorded no significant differences for biochemical recurrence-free, metastases-free and overall survival (all log-rank P > 0.05) according to marital status.
  
  
  CONCLUSIONS
  Marital status does not affect the clinical and pathological characteristics of radical prostatectomy patients treated at a high-volume center. Furthermore, marital status does not affect biochemical recurrence-free and metastases-free survival after radical prostatectomy.
authors.affiliation: Martini-Clinic Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.
authors.forename: Jonas
authors.initials: J
authors.lastname: Schiffmann
authors.forename: Burkhard
authors.initials: B
authors.lastname: Beyer
authors.forename: Pierre
authors.initials: P
authors.lastname: Tennstedt
authors.forename: Katharina
authors.initials: K
authors.lastname: Boehm
authors.forename: Gisa
authors.initials: G
authors.lastname: Mehring
authors.forename: Thorsten
authors.initials: T
authors.lastname: Schlomm
authors.forename: Georg
authors.initials: G
authors.lastname: Salomon
authors.forename: Pierre
authors.initials: P
authors.lastname: Karakiewicz
authors.forename: Markus
authors.initials: M
authors.lastname: Graefen
mesh_terms: D006801:Humans; D008297:Male; D017533:Marital Status / Q000706:statistics & numerical data*; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D057216:Propensity Score; D011467:Prostate / Q000601:surgery*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000601:surgery*; D012044:Regression Analysis; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: marital status; outcome; prostate cancer; radical prostatectomy; survival