title: [Modification of the cytogenetic effects of irradiation by water with the reduced content of deuterium and heavy isotopes of oxygen].
abstract: The influence of light water with the reduced content of heavy stable isotopes of oxygen and hydrogen (deuterium) on the cytogenetic status of irradiated animals was investigated. In mice, hybrids of the first generation (CBA x C57B1) F1, the increase in the output (two-fold at the dose of 2 Gy) of aberrant mitoses in the cells of bone marrow and the decrease in the duration of the mitotic index of the first cellular cycle occurred under the influence of the two week maintenance before the irradiation on light water with ppm 35 obtained by the method of rectification as compared with the irradiated animals that were kept on the distilled water. It has been discovered that 24 h after irradiation the number of leukocytes in the group which consumed light water is lower than that in the animals that were contained on the distilled water. Moreover, the cellularity of the bone marrow in the group which consumed light water was higher than that in the animals that were contained on distilled water. The prolonged application of light water before irradiation (for 14 days) led to an increase in the sensitivity of the chromosomal apparatus of mice to γ-irradiation against the background of an increase in the mitotic activity of cells.
authors.forename: S V
authors.initials: SV
authors.lastname: Vorozhtsova
authors.forename: A N
authors.initials: AN
authors.lastname: Abrosimova
authors.forename: E I
authors.initials: EI
authors.lastname: Kulikova
authors.forename: O V
authors.initials: OV
authors.lastname: Dorozhkina
authors.forename: M A
authors.initials: MA
authors.lastname: Kovalenko
authors.forename: D M
authors.initials: DM
authors.lastname: Kriuchkova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Severiukhin
authors.forename: V N
authors.initials: VN
authors.lastname: Gaevskiĭ
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Siniak
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects* / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000187:drug effects* / Q000528:radiation effects; D003903:Deuterium / Q000008:administration & dosage; D005720:Gamma Rays; D006859:Hydrogen / Q000008:administration & dosage / Q000737:chemistry; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D010103:Oxygen Isotopes / Q000008:administration & dosage; D014867:Water / Q000008:administration & dosage*; D014916:Whole-Body Irradiation
chemical_list: D010103:Oxygen Isotopes; D014867:Water; D006859:Hydrogen; D003903:Deuterium