title: Serum levels of sclerostin in cardiometabolic disorders during pregnancy.
abstract: OBJECTIVE
  Sclerostin has recently been introduced as a novel osteocyte-secreted factor which is associated with an adverse metabolic profile. However, regulation of circulating sclerostin in cardiometabolic disorders during pregnancy including gestational diabetes mellitus (GDM) and preeclampsia (PE) has not been comprehensively assessed, so far.
  
  
  METHODS
  Serum levels of sclerostin were quantified in 72 women with GDM and in 72 healthy, pregnant, gestational age-matched controls (study population 1). Furthermore, circulating sclerostin was assessed in 51 women with PE as compared to 51 pregnant controls in a second cohort (study population 2).
  
  
  RESULTS
  In the first study population (GDM), median [interquartile range] sclerostin levels were not significantly different in women with GDM as compared to controls (GDM: 19.2 [8.1]pmol/l; controls: 18.6 [7.1]pmol/l; p=0.906). Interestingly, C reactive protein was a negative and independent predictor of circulating sclerostin in the GDM cohort in multivariate analysis. In study population 2 (PE), serum levels of sclerostin were not different between women with PE and controls (PE: 18.8 [9.2]pmol/l; controls: 19.3 [8.8]pmol/l; p=0.504). Furthermore, the osteocyte-secreted factor was not related to any metabolic and gestational parameter in this cohort.
  
  
  CONCLUSIONS
  Sclerostin serum levels are not associated with an adverse metabolic profile during pregnancy in women with GDM and PE. The physiological significance of different associations of circulating sclerostin between pregnancy and non-pregnant status needs to be determined in future experiments.
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Platz
authors.affiliation: University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Stepan
authors.affiliation: University of Leipzig, Department of Obstetrics, 04103 Leipzig, Germany.
authors.forename: Susanne
authors.initials: S
authors.lastname: Schrey
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Susan
authors.initials: S
authors.lastname: Kralisch
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Wurst
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lossner
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.
authors.forename: Beate
authors.initials: B
authors.lastname: Jessnitzer
authors.affiliation: University of Leipzig, Institute of Laboratory Medicine, 04103 Leipzig, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kratzsch
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Fasshauer
authors.affiliation: University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address: thomas.ebert@medizin.uni-leipzig.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Ebert
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human
keywords: Gestational diabetes mellitus; Osteocyte; Preeclampsia; Pregnancy; Sclerostin