title: Effects of minocycline on learning and memory of mice following ischemic-hypoxic cerebral injuries.
abstract: An ischemic-hypoxic animal model was established using right common carotid artery occlusions and inhalation of low concentrations of oxygen in mice. At 10 days after the ischemic-hypoxic injuries, saline-treated mice exhibited significantly prolonged escape latencies in water-maze tests and significantly shorter memory latencies and more mistakes in step-down tests. In contrast, mice treated with 5 mg/kg minocycline exhibited significant reversals of each of these effects compared with the saline-treated control mice. Moreover, we found that minocycline can relieve brain water content and morphological changes in mice following ischemic-hypoxic cerebral injuries. Accordingly, our findings indicate that minocycline provides some protections against the deleterious effects of these injuries in mice.
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Yuanyin
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Zhong
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Shining
authors.initials: S
authors.lastname: Cai
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Shuling
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Physiology, Zhuhai Campus of Zunyi Medical College, Zhuhai 519041, Guangdong Province, China.
authors.forename: Quanzhong
authors.initials: Q
authors.lastname: Chang
keywords: cognition; ischemic-hypoxic cerebral injury; learning and memory; minocycline