title: Impaired immune response to Candida albicans in cells from Fanconi anemia patients.
abstract: Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. Several studies show alterations of the immunological status of FA patients including defects in peripheral blood lymphocyte subsets, serum immunoglobulin levels, and inflammatory cytokines. However scanty information is available on the response of FA cells to specific infectious antigens. In this work we examined the response of FA cells to different immunological stimuli and found a defective response of IL-1β, TNF-α and IL-17 to Candida albicans stimulation thus pointing to a potentially impaired response to fungal infections of FA patients.
authors.affiliation: Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Parodi
authors.affiliation: Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Kalli
authors.affiliation: Hematology Unit, Istituto Giannina Gaslini, 16148 Genova, Italy.
authors.forename: Johanna
authors.initials: J
authors.lastname: Svahn
authors.affiliation: Laboratorio Diagnosis Pre e Postnatale Malattie Metaboliche, Istituto Giannina Gaslini, 16148 Genova, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Stroppiana
authors.affiliation: Institute for Maternal and Child Health - IRCCS Burlo Garofoalo, Trieste, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: De Rocco
authors.affiliation: Hematology Unit, Istituto Giannina Gaslini, 16148 Genova, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Terranova
authors.affiliation: Hematology Unit, Istituto Giannina Gaslini, 16148 Genova, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Dufour
authors.affiliation: Centre of Excellence for Biomedical Research, University of Genova, Genova, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Fenoglio
authors.affiliation: Hematology Unit, Istituto Giannina Gaslini, 16148 Genova, Italy. Electronic address: enricocappelli@ospedale-gaslini.ge.it.
authors.forename: Enrico
authors.initials: E
authors.lastname: Cappelli
mesh_terms: D000293:Adolescent; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000096:biosynthesis; D005199:Fanconi Anemia / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007109:Immunity; D007223:Infant; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: Candida albicans; Fanconi anemia; IL-17; IL-1β; TNF-α