title: Correlation of zinc with oxidative stress biomarkers.
abstract: Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual's physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20-59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson's C=0.639; p=0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR=2.80 (95%CI=1.09-7.18) and AOR=3.06 (95%CI=0.96-9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.
authors.affiliation: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. maria.m.morales@uv.es.|CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. maria.m.morales@uv.es.|Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain. maria.m.morales@uv.es.
authors.forename: María
authors.initials: M
authors.lastname: Morales-Suárez-Varela
authors.affiliation: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. agustin.llopis@uv.es.|CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. agustin.llopis@uv.es.|Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain. agustin.llopis@uv.es.
authors.forename: Agustín
authors.initials: A
authors.lastname: Llopis-González
authors.affiliation: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain. veronica.gonzalez@uv.es.
authors.forename: Verónica
authors.initials: V
authors.lastname: González-Albert
authors.affiliation: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. rulo636@yahoo.es.
authors.forename: Raúl
authors.initials: R
authors.lastname: López-Izquierdo
authors.affiliation: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. isabelgonzlez@gmail.com.
authors.forename: Isabel
authors.initials: I
authors.lastname: González-Manzano
authors.affiliation: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain. felipe.chaves@uv.es.|CIBER de Diabetes y Enfermedades Metabólicas Asociados (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. felipe.chaves@uv.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Cháves
authors.affiliation: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain. vicente.huerta@uv.es.
authors.forename: Vicente
authors.initials: V
authors.lastname: Huerta-Biosca
authors.affiliation: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain. juancarlos.martinescudero@gmail.com.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Martin-Escudero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D016922:Cellular Senescence / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D019803:Glutathione Disulfide / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors; D013030:Spain; D055815:Young Adult; D015032:Zinc / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D015032:Zinc; D019803:Glutathione Disulfide