title: Decreased expression of Bauhinia purpurea lectin is a predictor of gastric cancer recurrence.
abstract: OBJECTIVE
  Molecular markers as indicators for gastric cancer recurrence are urgently required. The aim of this study was to identify lectins that can be used to predict gastric cancer recurrence after gastrectomy.
  
  
  METHODS
  We created lectin expression profiles by microarray analysis for 60 patients, who underwent surgery for gastric cancer at the Oita University Hospital between January, 2005 and December, 2007. Lectin expression and clinicopathological factors in patients who suffered gastric cancer recurrence and those who did not were compared by univariate and multivariate analyses.
  
  
  RESULTS
  Thirteen lectins showed a significant increase in binding to cancer tissues, whereas 11 lectins showed a significant decrease in binding to cancer tissues, when compared with binding to normal epithelia. Multivariate analysis revealed that lymph node metastasis and low Bauhinia purpurea lectin (BPL)-binding signals were independent predictive factors for recurrence. All patients with low BPL expression had significantly worse relapse-free survival than those with high BPL expression.
  
  
  CONCLUSIONS
  Our results using a novel lectin microarray system provide the first solid evidence that BPL expression is a predictor of gastric cancer recurrence.
authors.affiliation: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Yufu, Oita, 879-5593, Japan. takurof@oita-u.ac.jp.
authors.forename: Takuro
authors.initials: T
authors.lastname: Futsukaichi
authors.affiliation: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Yufu, Oita, 879-5593, Japan. teto@oita-u.ac.jp.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Etoh
authors.affiliation: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Yufu, Oita, 879-5593, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nakajima
authors.affiliation: Department of Diagnostic Pathology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Daa
authors.affiliation: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Yufu, Oita, 879-5593, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Shiroshita
authors.affiliation: Center for Community Medicine, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Shiraishi
authors.affiliation: Oita University, Oita, Japan.
authors.forename: Seigo
authors.initials: S
authors.lastname: Kitano
authors.affiliation: Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Hasama-machi, Yufu, Oita, 879-5593, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Inomata
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D037121:Plant Lectins / Q000378:metabolism*; D011237:Predictive Value of Tests; D040081:Protein Array Analysis / Q000379:methods; D011485:Protein Binding; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: C039340:Bauhinia purpurea lectin; D037121:Plant Lectins
keywords: Bauhinia purpurea lectin; Gastric cancer; Glycan; Lectin microarray; Recurrence