title: Nuclear receptors in vascular biology.
abstract: Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critically important mediators, nuclear receptors regulate the homeostatic control of lipids, carbohydrate, cholesterol, and xenobiotic drug metabolism, inflammation, cell differentiation and development, including vascular development. The nuclear receptor family is one of the most important groups of signaling molecules in the body and as such represent some of the most important established and emerging clinical and therapeutic targets. This review will highlight some of the recent trends in nuclear receptor biology related to vascular biology.
authors.affiliation: Comparative Biomedical Sciences, The Royal Veterinary College, Royal College Street, London, NW1 0TU, UK, dbishopbailey@rvc.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Bishop-Bailey
mesh_terms: D050197:Atherosclerosis / Q000235:genetics* / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism*; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear