title: Synthesis of polysubstituted quinolines via transition-metal-free oxidative cycloisomerization of o-cinnamylanilines.
abstract: An efficient synthesis of 2-aryl 4-substituted quinolines from stable and readily available o-cinnamylanilines, prepared from anilines and cinnamylalcohols, has been developed. The reaction occurred via a regioselective 6-endo-trig intramolecular oxidative cyclization using KO(t)Bu as a mediator and DMSO as an oxidant at rt. The reaction showed a broad substrate scope with good to excellent yields.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore By-pass Road, Bhouri, Bhopal-462066, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rehan
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore By-pass Road, Bhouri, Bhopal-462066, India.
authors.forename: Gurupada
authors.initials: G
authors.lastname: Hazra
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Indore By-pass Road, Bhouri, Bhopal-462066, India.
authors.forename: Prasanta
authors.initials: P
authors.lastname: Ghorai