title: The effect of topical ethanol extract of Cotinus coggygria Scop. on cutaneous wound healing in rats.
abstract: The aim of this study is to determine the cutaneous wound healing effects of the ethanol extract of Cotinus coggygria leaves in rats by excision wound model to provide scientific evidence for the traditional use of C. coggygria Scop. The levels of malondialdehyde, catalase, superoxide dismutase, glutathione and hydroxyproline were investigated in wound tissues. Histopathological examination was also performed. The hydroxyproline content of the granulation tissue and the glutathione levels were both significantly higher in the treatment group than in the control group (p < 0.05 for both); while the malondialdehyde levels were significantly lower in the treatment group (p < 0.05). These results were supported with histological results. The ethanol extract of C. coggygria Scop could be considered as an effective agent in wound healing in accordance with its traditional use.
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy , Marmara University , Istanbul , Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: b Clinical Pharmacy Department , Faculty of Pharmacy, Marmara University , Istanbul , Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Sancar
authors.affiliation: c Department of Pharmacognosy, Faculty of Pharmacy , Marmara University , Istanbul , Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Sen
authors.affiliation: b Clinical Pharmacy Department , Faculty of Pharmacy, Marmara University , Istanbul , Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Okuyan
authors.affiliation: c Department of Pharmacognosy, Faculty of Pharmacy , Marmara University , Istanbul , Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Bitis
authors.affiliation: a Department of Biochemistry, Faculty of Pharmacy , Marmara University , Istanbul , Turkey.
authors.forename: Fikriye
authors.initials: F
authors.lastname: Uras
authors.affiliation: d Histology-Embryology Department , Faculty of Medicine, Marmara University , Istanbul , Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Akakin
authors.affiliation: e Department of Biochemistry, Faculty of Pharmacy , Cumhuriyet University , Sivas , Turkey.
authors.forename: Ozge
authors.initials: O
authors.lastname: Cevik
authors.affiliation: f Department of Pharmaceutical Botany, Faculty of Pharmacy , Istanbul University , Istanbul , Turkey.
authors.forename: Sukran
authors.initials: S
authors.lastname: Kultur
authors.affiliation: b Clinical Pharmacy Department , Faculty of Pharmacy, Marmara University , Istanbul , Turkey.
authors.forename: Fikret Vehbi
authors.initials: FV
authors.lastname: İzzettin
mesh_terms: D027926:Anacardiaceae / Q000737:chemistry*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D006909:Hydroxyproline
keywords: Cotinus coggygria Scop; hydroxyproline; wound healing