title: Molecular and Physiological Factors of Neuroprotection in Hypoxia-tolerant Models: Pharmacological Clues for the Treatment of Stroke.
abstract: The naked mole-rat possesses several unique physiological and molecular features that underlie their remarkably and exceptional resistance to tissue hypoxia. Elevated pattern of Epo, an erythropoietin (Epo) factor; c-fos; vascular endothelial growth factor (VEGF); and hypoxia-inducible factors (HIF-1α) contribute to the adaptive strategy to cope with hypoxic stress. Moreover, the naked mole-rat has a lower metabolic rate than any other eutherian mammal of comparable size that has been studied. The ability to actively reduce metabolic rate represents a strategy widely used in the face of decreased tissue oxygen availability. Understanding the different molecular and physiological factors that induce metabolic suppression could guide the development of pharmacological agents for the clinical management of stroke patient.
authors.affiliation: University of South Carolina School of Medicine-Greenville, Greenville, SC, USA.
authors.forename: Thomas I
authors.initials: TI
authors.lastname: Nathaniel
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: Julius O
authors.initials: JO
authors.lastname: Soyinka
authors.affiliation: Department of Health Science, Eastern Tennessee State University, Johnson City, TN, USA.
authors.forename: Adekunle
authors.initials: A
authors.lastname: Adedeji
authors.affiliation: Department of Biology, North Greenville University, Tigerville, SC, USA.
authors.forename: Adebobola
authors.initials: A
authors.lastname: Imeh-Nathaniel
keywords: brain injury; hypoxia; metabolic suppression; naked mole-rats; neuroprotection; stroke