title: Serum mannose-binding lectin is a strong biomarker of diabetic retinopathy in chinese patients with diabetes.
abstract: OBJECTIVE
  Inflammation and complement activation initiated by mannose-binding lectin (MBL) may be implicated in the pathogenesis of diabetic vascular complications. We investigated serum MBL levels in patients with diabetes with and without diabetic retinopathy (DR).
  
  
  METHODS
  Serum MBL levels were determined in 348 patients with diabetes and in 100 healthy control subjects. The prediction value of MBL was compared with diabetes duration, hs-CRP, and other known predictors. Multivariate analyses were performed using logistic regression models.
  
  
  RESULTS
  MBL levels on admission were significantly increased in patients with diabetes with DR (P < 0.0001) and vision-threatening DR (VTDR; P < 0.0001). Multivariate logistic regression analysis adjusted for common indictors showed that serum MBL levels ≥3,385 μg/L were an independent predictor of DR (odds ratio [OR] 3.14, 95% CI 1.77-5.57) and VTDR (OR 7.83, 95% CI 3.35-18.31). The area under the receiver operating characteristic curve of MBL was 0.81 (95% CI 0.76-0.86) for DR and 0.84 (95% CI 0.74-0.93) for VTDR.
  
  
  CONCLUSIONS
  The current study demonstrated that MBL appears to be an independent biomarker for DR in the Chinese population, suggesting a possible role of MBL in the pathogenesis of DR complications in diabetes.
authors.affiliation: Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China Division of Internal Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China Institute of Hepatobiliary Diseases, Beijing Tsinghua Changgung Hospital, Beijing, China Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
authors.affiliation: Department of Pharmacy, General Hospital of Beijing Military Area Command, Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Stomatology, General Hospital of Beijing Military Area Command, Beijing, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.affiliation: Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, China gengpeiliang@hotmail.com.
authors.forename: Yinying
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D003167:Complement Activation / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000208:ethnology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000208:ethnology; D003930:Diabetic Retinopathy / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D037601:Mannose-Binding Lectin / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D037601:Mannose-Binding Lectin