title: The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer.
abstract: Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue of Cancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence.
authors.affiliation: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Moses
authors.affiliation: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.
authors.forename: Len
authors.initials: L
authors.lastname: Neckers
mesh_terms: D026924:Amino Acid Transport System A / Q000378:metabolism*; D026962:Amino Acid Transport System ASC / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology*; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects*; D005260:Female; D006801:Humans; D015778:Minor Histocompatibility Antigens; D017239:Paclitaxel / Q000494:pharmacology*; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*
chemical_list: D026924:Amino Acid Transport System A; D026962:Amino Acid Transport System ASC; D000970:Antineoplastic Agents; D004268:DNA-Binding Proteins; D015778:Minor Histocompatibility Antigens; C420506:SLC1A5 protein, human; C498797:SLC38A2 protein, human; C111501:RNF5 protein, human; D044767:Ubiquitin-Protein Ligases; D017239:Paclitaxel