title: [Treatment for chronic hepatitis C with thrombocytopenia].
abstract: Thrombocytopenia in patients with chronic hepatitis C represents an obstacle for the initiation of antiviral treatment. Antiviral treatment with pegylated interferon α and ribavirin has contributed to a significant increase in the rate of sustained virological response. However, patients with thrombocytopenia is ineligible for antiviral treatment or, if able to start treatment, may require a dose reduction or even discontinuation due to the haematological adverse effects. We here review the efficacy and safety of antiviral treatment after splenectomy and partial splenic embolization, and the potential effect of platelet count increase by interferon β.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Furusyo
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ogawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Murata
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
mesh_terms: D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D013156:Splenectomy; D013921:Thrombocytopenia / Q000150:complications*
chemical_list: D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a