title: Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyls as possible anti-tubercular and antimicrobial agents.
abstract: A series of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyl derivatives, 25-64 were synthesized and evaluated for inhibitory activity against Mycobacterium smegmatis MC(2) 155 strain and antimicrobial activities against four pathogenic bacteria Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Proteus vulgaris. Among them, compounds 40, 49, 50, and 54 exhibited moderate to good inhibition on the growth of the bacteria Mycobacterium smegmatis at the concentration of 30 μM. Compounds 26, 40, 44, 54 and 56 exhibited moderate to good antibacterial activity. Compound 5-(2'-(4-fluorobenzyl)thiazol-4'-yl)-2-(4-fluorophenyl)-4-methyl-thiazole (54) exhibited both antitubercular as well as antimicrobial activity against all tested strains.
authors.affiliation: Post-Graduate Department of Chemistry and Research Centre, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, College Road, District Ahmednagar, Sangamner 422 605, India.
authors.forename: Yogita K
authors.initials: YK
authors.lastname: Abhale
authors.affiliation: Post Graduate Department of Chemistry, S. P. Mandali's Sir Parashurambhau College, Tilak Road, 411 030 Pune, India.
authors.forename: Amit V
authors.initials: AV
authors.lastname: Sasane
authors.affiliation: Post Graduate Department of Chemistry, S. P. Mandali's Sir Parashurambhau College, Tilak Road, 411 030 Pune, India.
authors.forename: Abhijit P
authors.initials: AP
authors.lastname: Chavan
authors.affiliation: Post-Graduate Department of Chemistry and Research Centre, S. N. Arts, D. J. M. Commerce and B. N. S. Science College, College Road, District Ahmednagar, Sangamner 422 605, India.
authors.forename: Keshav K
authors.initials: KK
authors.lastname: Deshmukh
authors.affiliation: Center for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Sudha Sravanti
authors.initials: SS
authors.lastname: Kotapalli
authors.affiliation: Center for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Ummanni
authors.affiliation: Amrutvahini College of Pharmacy, Amrutnagar, P. O. Sangamner (S.K.), Tal. Dist. Ahmednagar, 422 608 Sangamner, Maharashtra, India.
authors.forename: Sadikali F
authors.initials: SF
authors.lastname: Sayyad
authors.affiliation: Post Graduate Department of Chemistry, S. P. Mandali's Sir Parashurambhau College, Tilak Road, 411 030 Pune, India. Electronic address: mhaskepc18@gmail.com.
authors.forename: Pravin C
authors.initials: PC
authors.lastname: Mhaske
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C000603762:5-(2'-(4-fluorobenzyl)thiazol-4'-yl)-2-(4-fluorophenyl)-4-methylthiazole; D000900:Anti-Bacterial Agents; D013844:Thiazoles
keywords: Antibacterial activity; Bithiazoles; Mycobacterium smegmatis