title: Impact of low-dose urokinase in peritoneal dialysis on serum oxidative stress, nitric oxide and endothelin in cerebral infarction complicated with uremia.
abstract: BACKGROUND
  Cerebrovascular accident is an important cause of death in patients with chronic renal failure.
  
  
  METHODS
  This study evaluated the interference of low-dose urokinase in peritoneal dialysis solution on uremic serum superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and endothelin (ET) dynamics in patients with a cerebral infarction complicated by uremia.
  
  
  RESULTS
  Both the urokinase and conventional treatment groups showed decreased SOD activities, increased MDA content, and elevated serum NO and ET levels at the initiation stage of treatment. Antiplatelet and cerebral protection therapy slightly reduced body MDA content and increased SOD activity at the early stage of treatment, and its effects on reducing serum NO and ET-1 are also limited.
  
  
  CONCLUSIONS
  Our results revealed that a small amount of urokinase in peritoneal dialysis can reduce body MDA content, increase SOD activity and decrease serum levels of NO and ET-1 at the early stage of cerebral infarction complicated by uremia. We also found that continuous treatment for 8 weeks may provide a potential treatment of cerebral infarction complicated with uremia.
authors.affiliation: Department of Neurology, Shanghai Jiao Tong University Affiliated The Sixth People's Hospital Yi Shan Road 600, Shanghai 200233, China.
authors.forename: Zhong-Sen
authors.initials: ZS
authors.lastname: Qu
authors.affiliation: Department of Internal Medicine, Heze High Medical School Heze 274030, China.
authors.forename: Qing-De
authors.initials: QD
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Qingdao University Affiliated The Central Hospital Qingdao 266042, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
keywords: Low-dose urokinase; cerebral infarction; nitric oxide; oxidative stress; peritoneal dialysis