title: Body mass index and age are predictors for symptom improvement after high-power laser vaporization for benign prostatic hyperplasia.
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of high-power 120W Greenlight HPS laser (HPS) and compare the results to transurethral resection of the prostate (TURP), and define a subgroup of patients who had better symptom score improvement after HPS.
  
  
  METHODS
  One hundred and twenty-five patients who underwent surgery for benign prostatic hyperplasia (BPH) (61 HPS and 64 TURP) were retrospectively followed. Improvements of International Prostate Symptom Score (IPSS), quality of life score (QoL), maximum flow rate (Qmax) and post-void residual (PVR) were assessed at 4 weeks after the procedures. Potential covariates including age, body mass index (BMI), prostate volume (PV) and serum prostate-specific antigen (PSA) were defined and further subgroup analyses were utilized.
  
  
  RESULTS
  The HPS group had a significantly higher education level, annual household income and larger prostate size. Compared with TURP, HPS resulted in comparable IPSS, QoL, Qmax and PVR improvements, but shorter hospitalization duration, serum hemoglobin loss and blood transfusion rate. Subgroup analyses showed that men in the HPS group were younger (age<76 years), had higher BMI (≥24kg/m(2)) and greater adjusted IPSS and QoL improvements than men in the TURP group.
  
  
  CONCLUSIONS
  HPS offered adequate effectiveness for symptomatic BPH versus TURP and was advantageous with regard to operative safety. Patients who are younger and have higher BMI may achieve better improvements with HPS than with TURP. Further long-term follow-up study is warranted.
authors.affiliation: Department of Surgery, Yong He Branch, Cardinal Tien Hospital, New Taipei City, Taiwan; College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Teng-Kai
authors.initials: TK
authors.lastname: Yang
authors.affiliation: Division of Urology, Department of Surgery, Cardinal Tien Hospital, Taipei, Taiwan; College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Po-Jen
authors.initials: PJ
authors.lastname: Hsiao
authors.affiliation: Department of Surgery, Yong He Branch, Cardinal Tien Hospital, New Taipei City, Taiwan.
authors.forename: Hung-Ju
authors.initials: HJ
authors.lastname: Yang
authors.affiliation: Division of Urology, Department of Surgery, Cardinal Tien Hospital, Taipei, Taiwan; College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Chun-Hou
authors.initials: CH
authors.lastname: Liao
authors.affiliation: Division of Urology, Department of Surgery, Cardinal Tien Hospital, Taipei, Taiwan; College of Medicine, Fu-Jen Catholic University, Taipei, Taiwan.
authors.forename: Han-Sun
authors.initials: HS
authors.lastname: Chiang
authors.affiliation: Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. Electronic address: klchien@ntu.edu.tw.
authors.forename: Kuo-Liong
authors.initials: KL
authors.lastname: Chien
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D007902:Length of Stay; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000601:surgery*; D011788:Quality of Life / Q000523:psychology*; D012189:Retrospective Studies; D013624:Taiwan; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome
chemical_list: D017430:Prostate-Specific Antigen
keywords: benign prostatic hyperplasia; international prostatic symptoms score; laser vaporization; predictor; subgroup