title: NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty.
abstract: Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased. In fact, the use of MSCs for MI treatment, known as cellular cardiomyoplasty, is in the clinical trial stage. However, despite promising results, most MSCs die after transplantation as a result of exposure to various stresses. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a well-known cytoprotective transcription factor, protects MSCs against some stresses. Over-expression of Nrf2 in MSCs decreases their apoptosis in vitro without any adverse effects on their differentiation capacity. Therefore, we hypothesized that over-expression of Nrf2 in MSCs can improve cellular cardiomyoplasty.
authors.affiliation: Ph.D., Assistant Professor, Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadzadeh-Vardin
authors.affiliation: Ph.D., Associated Professor, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
authors.forename: Mehryar Habibi
authors.initials: MH
authors.lastname: Roudkenar
keywords: Cardiomyoplasty; Mesenchymal Stromal Cells; Myocardial Infarction; NF-E2-Related Factor 2 (Nrf2)