title: The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.
abstract: Growing evidence indicates that the vitamin D receptor (VDR) gene is an important candidate gene for influencing the development of osteoporosis. The aim of the study was to evaluate the potential association between genetic variants of VDR gene and bone mineral density (BMD) and osteoporosis in Chinese postmenopausal women. The study included 970 Chinese postmenopausal women at the postmenopausal osteoporosis (482) and healthy controls (488). The BMD of lumbar spine (L(2-4) anterior-posterior view), femoral neck hip, and total hip was evaluated using the Norland XR-46 dual energy X-ray absorptiometry (DEXA). The genotypes of VDR genetic variants were determined by the created restriction site-PCR (CRS-PCR) and confirmed by DNA sequencing methods. Our data indicated that the VDR p.Glicine (Gly)14 alanine (Ala) and p.histidine (His) 305 glutanine (Gln) genetic variants were statistically associated with adjusted femoral neck hip BMD, adjusted lumbar spine BMD, and adjusted total hip BMD (P values < 0.05). Results from this study suggest that the VDR p.Gly14Ala and p.His305Gln genetic variants are significantly associated with BMD decrease in Chinese postmenopausal women and might be used as molecular markers for assessing the risk of BMD and osteoporosis.
authors.affiliation: Department of Orthopedics, The 305 Hospital of Chinese PLA, Beijing 100017, China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Orthopedics, The 305 Hospital of Chinese PLA, Beijing 100017, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100037, China.
authors.forename: Xiaonan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, The 305 Hospital of Chinese PLA, Beijing 100017, China.
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Qing
authors.affiliation: Department of Orthopedics, The 305 Hospital of Chinese PLA, Beijing 100017, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D010024:Osteoporosis / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human