title: Rizatriptan benzoate influences the endogenous pain modulatory system in a rat model of migraine.
abstract: The present study utilized a nitroglycerin-induced rat model of migraine to detect the effects of rizatriptan benzoate on proenkephalin and substance P gene expression in the midbrain using real-time quantitative polymerase chain reaction and investigate whether rizatriptan benzoate can regulate the endogenous pain modulatory system. The results showed that rizatriptan benzoate significantly reduced expression of the mRNAs for proenkephalin and substance P. Rizatriptan benzoate may inhibit the analgesic effect of the endogenous pain modulatory system.
authors.affiliation: Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China ; Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yao
authors.affiliation: Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Man
authors.affiliation: Department of Food Science, College of Quartermaster Technology, Jilin University, Changchun 130000, Jilin Province, China.
authors.forename: Xiangdan
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Neurology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
authors.forename: Tingmin
authors.initials: T
authors.lastname: Yu
authors.affiliation: Liaoyuan Vocational Technical and Medical College, Liaoyuan 136200, Jilin Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ji
keywords: midbrain; migraine; pain; proenkephalin; real-time quantitative polymerase chain reaction; rizatriptan benzoate; substance P