title: The relationship between benign paroxysmal positional vertigo and thyroid autoimmunity.
abstract: CONCLUSIONS
  Although there have been few studies concerning BPPV and thyroid autoimmunity and a positive relation was found between them, this study didn't find any relation between BPPV and thyroid autoimmunity. IT is thought that further large-scale studies must be done to clarify the relation.
  
  
  OBJECTIVE
  Benign paroxysmal positional vertigo (BPPV) consists of ∼ 20% of vestibular disorders. Self-limited rotatory nystagmus with positional vertigo are the main findings of BPPV. Although canalolithiasis theory was confirmed by demonstrating freely floating debris in the endolymph of the posterior semicircular channel in following studies, currently, the etiology hasn't been explained totally. This study investigated the relation of BPPV and thyroid autoimmunity evaluated via measurement of serum thyroid autoantibodies.
  
  
  METHODS
  Fifty patients (37 female, 13 male) with BPPV (BPPV group), 52 patients (40 female, 12 male) with non-BPPV vertigo (non-BPPV group) and 60 otherwise normal control (38 female, 22 male) samples were enrolled in the study. All samples of BPPV, non-BPPV groups and controls had undergone a cochleovestibular test following thorough ENT examination. After blood samples were drawn from each subject, thyroid-stimulating hormone (TSH), anti-thyroid peroxidase antibody (TPO-Ab) and anti-thyroglobulin antibody (TG-Ab) levels were measured accordingly.
  
  
  RESULTS
  In the study, eight patients of the BPPV group (16%) had a high thyroid antibody level. In the non-BPPV group, six patients (11.5%) had elevated thyroid antibodies. In the control group, 15 patients (25%) had elevated thyroid antibodies. TSH values of all subjects were detected to be within normal range. No statistical difference was found between the groups with respect to TG-Ab and TPO-Ab values (p-values = 0.729 and 0.812, respectively).
authors.affiliation: Department of Otolaryngology & Head and Neck Surgery.
authors.forename: Kamran
authors.initials: K
authors.lastname: Sari
authors.forename: Tekin
authors.initials: T
authors.lastname: Yildirim
authors.forename: Hasan
authors.initials: H
authors.lastname: Borekci
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
authors.forename: Reha
authors.initials: R
authors.lastname: Aydin
authors.forename: Mahmut
authors.initials: M
authors.lastname: Ozkiris
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism*; D015551:Autoimmunity; D065635:Benign Paroxysmal Positional Vertigo / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D012189:Retrospective Studies; D013961:Thyroid Gland / Q000276:immunology* / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000276:immunology* / Q000378:metabolism
chemical_list: D001323:Autoantibodies; C056626:thyroid microsomal antibodies
keywords: Positional vertigo; anti-thyroglobulin antibody; anti-thyroid peroxidase antbody; autoimmun thyroidit; immun complex