title: Copper-catalyzed aerobic cascade cycloamination and acyloxylation: a direct approach to 4-acyloxy-1H-pyrazoles.
abstract: A novel direct transformation of hydrazones to acyloxylated pyrazoles by copper-catalyzed regioselective olefinic C(sp(2))-H bond cycloamination and acyloxylation was performed under mild conditions, which combines the formation of the pyrazole skeleton and installation of an acyloxyl group in a single step, using facile carboxylic acids as the acyloxylation reagents.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444, China. xubin@shu.edu.cn.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Ding
authors.forename: Qitao
authors.initials: Q
authors.lastname: Tan
authors.forename: Mingchun
authors.initials: M
authors.lastname: Gao
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015195:Drug Design; D006834:Hydrazines / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry*; D006860:Hydrogen Bonding; D008024:Ligands; D008670:Metals / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D006834:Hydrazines; D006835:Hydrazones; D008024:Ligands; D008670:Metals; D009930:Organic Chemicals; D011720:Pyrazoles; C029424:hydrazine; D003300:Copper