title: Toxicity of anthraquinones: differential effects of rumex seed extracts on rat organ weights and biochemical and haematological parameters.
abstract: The genus Rumex and related species such as Rheum and Polygonum are widely used as medicinal herbs and foods. They contain anthraquinones (AQ) such as emodin and chrysophanol as active ingredients, and there is concern about the toxicity of these compounds. This study evaluated the chronic effects of Rumex patientia seed aqueous and ethanolic extracts, in male and female rats separately, on organ weights and over 30 haematological, biochemical and histological parameters, immediately after 14-week administration and after a further period of 15 days without drug treatment. Adverse changes were associated with long-term AQ administration, and these focussed on the liver, lung and kidney, but after 15-day convalescence, most had reverted to normal. In general, male rats appeared to be more susceptible than female rats at similar doses. The water extract produced no irreversible changes, which may reflect the lower dose of the AQ constituents or the presence of different ancillary compounds, and supports the traditional method of extracting Rumex seeds with water. In conclusion, ethanolic extracts of R. patientia caused irreversible pathological changes at very high doses (4000mg/kg), but lower doses and aqueous extracts produced either non-significant or reversible changes. Long-term administration of high doses of AQ extracts over a long period of time should be avoided until further assurances can be given, and given other existing reports of reproductive toxicity, should be avoided altogether during pregnancy.
authors.affiliation: Department of Pharmacology, Basic Medical College of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China; Centre for Evaluation of Drug Safety, Xinjiang Institute of Traditional Uyghur Medicine, Urumqi, Xinjiang, People's Republic of China.
authors.forename: Rabigul
authors.initials: R
authors.lastname: Islam
authors.forename: Yultuz
authors.initials: Y
authors.lastname: Mamat
authors.forename: Ilyar
authors.initials: I
authors.lastname: Ismayil
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Mahsutjan
authors.initials: M
authors.lastname: Kadir
authors.forename: Abdujilil
authors.initials: A
authors.lastname: Abdugheny
authors.forename: Haximjan
authors.initials: H
authors.lastname: Rapkat
authors.forename: Mardan
authors.initials: M
authors.lastname: Niyaz
authors.forename: Yusupjan
authors.initials: Y
authors.lastname: Ali
authors.forename: Sirapil
authors.initials: S
authors.lastname: Abay
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology / Q000633:toxicity*; D004642:Emodin / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D031804:Rumex / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D036401:Toxicity Tests, Chronic
chemical_list: D000880:Anthraquinones; D010936:Plant Extracts; D004642:Emodin; C027113:chrysophanic acid
keywords: Rumex patientia L; biochemistry; chrysophanol; emodin; haematology; histopathology; toxicity