title: The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome.
abstract: OBJECTIVE
  The present paper aimed at reviewing literature data on the inflammatory hypothesis of mood spectrum, as well as the overlapping features with some chronic rheumatologic disorders, in particular fibromyalgia and chronic fatigue syndrome.
  
  
  METHODS
  A literature search was carried out for English papers published in the years 2000-2014, while using the following words: mood spectrum, depression, bipolar disorders, fibromyalgia, chronic fatigue syndrome, neurotransmitters, inflammation, neuroinflammation, cytokines.
  
  
  RESULTS
  Overlapping features were highlighted between mood spectrum, fibromyalgia and chronic fatigue syndrome suggesting common underlying mechanisms at pathophysiological level involving both central nervous and the immune systems.
  
  
  CONCLUSIONS
  Taken together, the literature would suggest that the borders between different medical domains should be reconsidered in the light of common processes linking them.
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
authors.affiliation: Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Bazzichi
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Baroni
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Falaschi
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Conversano
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Carmassi
authors.affiliation: Section of Psychiatry, Department of Clinical and Experimental Medicine, University of Pisa, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Marazziti
mesh_terms: D000339:Affect; D000818:Animals; D016207:Cytokines; D015673:Fatigue Syndrome, Chronic / Q000276:immunology / Q000378:metabolism / Q000523:psychology*; D005356:Fibromyalgia / Q000276:immunology / Q000378:metabolism / Q000523:psychology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000523:psychology*; D018836:Inflammation Mediators / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators