title: An aqueous fluorescent probe for Hg(2+) detection with high selectivity and sensitivity.
abstract: An aqueous fluorescent probe, 1, was developed for the rapid detection of Hg(2+) with high sensitivity and excellent selectivity. Upon the addition of Hg(2+) in pure aqueous media, the Hg(2+)-mediated hydrolysis of vinyl ether and subsequent cyclization reactions converted probe 1 into the corresponding iminocoumarin dye, which is strongly fluorescent when excited. The application of this probe for the detection of intracellular Hg(2+) was successfully demonstrated in living cells.
authors.affiliation: College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan Province, Peoples Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Fang
authors.affiliation: College of Chemical Engineering and Modern Materials, Shangluo University, Shangluo, Shanxi Province, Peoples Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan Province, Peoples Republic of China.|State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan Province, Peoples Republic of China.|State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, Liaoning Province, Peoples Republic of China.
authors.forename: Xiangzhi
authors.initials: X
authors.lastname: Song
authors.affiliation: The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, Peoples Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008628:Mercury / Q000032:analysis*; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D008628:Mercury
keywords: Hg2+; fluorescent probe; hydrolysis reaction; vinyl ether; water-soluble