title: The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature.
abstract: Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke. Some studies have found that UA is a predictor for stroke by mechanisms involved in development. There are some controversies about whether it is an independent effect of UA or an epiphenomenon. UA has been widely concerned for its neuroprotective effect as an antioxidant. In some experimental models of acute ischemic stroke, UA levels are associated with better functional recovery because of its synergistic effect with alteplase. In this review, a comprehensive literature search was conducted through Pubmed (1980-October 2014) to review the association of UA with the outcome of stroke. Finally, we outline the available clinical trial data supporting UA as a type of neuroprotective agents for the ischemic stroke.
authors.affiliation: Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Guo
authors.forename: Sheng
authors.initials: S
authors.lastname: Tan
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D018696:Neuroprotective Agents / Q000378:metabolism / Q000627:therapeutic use*; D039781:PubMed / Q000706:statistics & numerical data; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014527:Uric Acid / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D018696:Neuroprotective Agents; D014527:Uric Acid; D010959:Tissue Plasminogen Activator