title: Single fraction volumetric modulated arc radiosurgery of brain metastases.
abstract: OBJECTIVE
  To show the clinical results of the treatment of brain metastases via radiosurgery using Volumetric Modulated Arc Therapy (VMAT).
  
  
  METHODS
  52 patients having lung (62 %), breast (17 %), colorectal (8 %) and other cancers (13 %) with one to three brain metastases were treated with 5 non-coplanar VMAT arcs. The treatment dose varied from 12 to 20 Gy, administered in one single session. The volume of metastases ranged from 0.04 to 24.92 cc. Radiosurgery alone was used for 54 % of cases, while 19 % received whole brain radiotherapy due to relapse. Patients were classified according to the Disease-specific graded prognostic assessment (DS-GPA) index and survival was assessed via the Kaplan-Meier model.
  
  
  RESULTS
  The median survival time was 7.2 months from the date of radiosurgery. The Karnofsky and DS-GPA indices were the most significant with regard to survival. Patients with a Karnofsky performance status (KPS) over 70 had a longer survival time of 9.2 months, as opposed to those with a KPS below 70 of 3.5 months. No significant differences were found with regard to the type of cancer or the number of lesions. Local tumour control was achieved for 42 metastases (82 %), of which a complete response was achieved for 7 lesions, a partial response for 21; 15 lesions were stabilized. Local progression was observed in 8 lesions (15 %). The median treatment time per patient was 29 min.
  
  
  CONCLUSIONS
  The VMAT technique proves to be safe and effective for treating brain metastases via radiosurgery.
authors.affiliation: Department of Medical Physics and Radiation Protection, Santa Lucia University Hospital, 30202, Cartagena, Murcia, Spain, asernaberna@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Serna
authors.forename: P P
authors.initials: PP
authors.lastname: Escolar
authors.forename: V
authors.initials: V
authors.lastname: Puchades
authors.forename: F
authors.initials: F
authors.lastname: Mata
authors.forename: D
authors.initials: D
authors.lastname: Ramos
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez
authors.forename: A
authors.initials: A
authors.lastname: Iglesias
authors.forename: J
authors.initials: J
authors.lastname: Salinas
authors.forename: M
authors.initials: M
authors.lastname: Alcaraz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D011379:Prognosis; D016634:Radiosurgery / Q000401:mortality*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000401:mortality*; D015996:Survival Rate