title: Mild Cognitive Impairment Subtypes in Older People With Depressive Symptoms: Relationship With Clinical Variables and Hippocampal Change.
abstract: OBJECTIVE
  To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms and to determine the relative contribution of hippocampal volume and MCI to memory change.
  
  
  METHODS
  One hundred and fifty-two participants with lifetime Major Depression and remitted or mild symptoms and 28 healthy controls underwent psychiatric and neuropsychological assessments. Magnetic resonance imaging was also conducted in a subset of the patients (n = 81) and healthy controls (n = 18).
  
  
  RESULTS
  MCI was diagnosed in 75.7% of the patients and was associated with increasing age, medical burden, vascular risk factors, later age of depression onset and smaller hippocampi. Multiple regression showed that both hippocampal volume and MCI diagnosis mediate memory performance in depression.
  
  
  CONCLUSIONS
  MCI occurs in older adults with a history of depression and is not simply due to symptom severity. Memory change is linked to underlying hippocampal atrophy in this patient group.
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Hirosha K
authors.initials: HK
authors.lastname: Jayaweera
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Shantel L
authors.initials: SL
authors.lastname: Duffy
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hermens
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Loren
authors.initials: L
authors.lastname: Mowszowski
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Keri
authors.initials: K
authors.lastname: Diamond
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Terpening
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Matthew
authors.initials: M
authors.lastname: Paradise
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Simon J G
authors.initials: SJ
authors.lastname: Lewis
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Jim
authors.initials: J
authors.lastname: Lagopoulos
authors.affiliation: Healthy Brain Ageing Program, Brain & Mind Research Institute, University of Sydney, Sydney, Australia Clinical Research Unit, Brain & Mind Research Institute, University of Sydney, Sydney, Australia sharon.naismith@sydney.edu.au.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001284:Atrophy / Q000473:pathology; D060825:Cognitive Dysfunction / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D003863:Depression / Q000523:psychology*; D003865:Major Depressive Disorder; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008568:Memory; D008875:Middle Aged; D059906:Neuroimaging; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors
keywords: Depression; MRI; Memory; Mild Cognitive Impairment; Neuroimaging