title: Detection of subclinical recurrence or second primary cancer using (18) F-FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma.
abstract: The efficacy of posttreatment surveillance (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG PET)/CT was evaluated in patients with head and neck squamous cell carcinoma (HNSCC).
  
  
  
  The subjects were 158 patients with HNSCC who underwent PET/CT after definitive treatment. PET/CT detection of subclinical recurrence or a second primary cancer and the effect of timing of PET/CT scans on survival were analyzed.
  
  
  
  Recurrence or a second primary cancer occurred in 70 patients, and 67% of these cases were detected by PET/CT. Detection rates were 17%, 9%, 5%, and 5% in the first, second, third, and fourth scans at 4, 9, 15, and 21 months, respectively. In multivariate analysis, patients who underwent early first scans had significantly better disease-specific (hazard ratio [HR] = 0.37; p = .031) and overall (HR = 0.45; p = .040) survival compared with those who underwent late first scans.
  
  
  
  Earlier detection of subclinical lesions by surveillance PET/CT within 4 months after treatment may improve survival in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E511-E518, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Shinohara
authors.affiliation: Department of Radiology, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Megumu
authors.initials: M
authors.lastname: Hino
authors.affiliation: Department of Radiology, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Kyo
authors.initials: K
authors.lastname: Itoh
authors.affiliation: Institute of Biomedical Research and Innovation Hospital, Kobe, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Tona
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Kishimoto
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Harada
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Suehiro
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe City Medical Center General Hospital, Kobe, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D012189:Retrospective Studies
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT; head and neck cancer; recurrence; second primary cancer; surveillance