title: Does time to endoscopic sinus surgery impact outcomes in chronic rhinosinusitis? Retrospective analysis using the UK clinical practice research data.
abstract: Patients with chronic rhinosinusitis (CRS) refractory to medical management may elect endoscopic sinus surgery (ESS). Recent data showed that clinical outcomes of patients treated earlier outperformed those of patients treated later in the disease continuum. In this study, CRS-related healthcare utilisation of patients treated early versus late was analysed using the UK-based Clinical Practice Research Database.
  
  
  
  Two cohorts ("Early Cohort": ESS within 12 months of first CRS diagnosis, versus "Late Cohort": ≥ 5 years from diagnosis to ESS) were matched for age, gender, asthma, polyposis. Healthcare needs related to CRS were analysed post-operatively for 5 years.
  
  
  
  Patients in the Late cohort used significantly more CRS-related care than patients in the Early cohort visits and 0.54 prescriptions per patient per year. A sub-analysis of patients with and without asthma indicated that patients in the Late cohort without asthma had healthcare needs equivalent to patients in the Early cohort with asthma.
  
  
  
  Delayed surgical intervention for CRS is associated with greater post-operative healthcare needs than ESS within 12 months of first CRS diagnosis.
authors.forename: C
authors.initials: C
authors.lastname: Hopkins
authors.forename: P
authors.initials: P
authors.lastname: Andrews
authors.forename: C E
authors.initials: CE
authors.lastname: Holy
mesh_terms: D001249:Asthma / Q000150:complications; D002908:Chronic Disease; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications; D012220:Rhinitis / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery*; D013222:State Medicine; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom; D014850:Waiting Lists