title: Target radiofrequency combined with collagenase chemonucleolysis in the treatment of lumbar intervertebral disc herniation.
abstract: Both target radiofrequency thermocoagulation and collagenase chemonucleolysis are effective micro-invasive therapy means for lumbar intervertebral disc herniation. In order to analyze the clinical effects of target radiofrequency thermocoagulation combined with collagenase chemonucleolysis on lumbar intervertebral disc herniation, the contents of hydroxyproline and glycosaminoglycan were measured and the histological changes of nucleus pulposus was detected in the vitro experiments. Radiofrequency thermocoagulation reduced the hydrolyzation of herniated nucleus pulposus caused by collagenase, as well as the content of hydroxyproline and glycosaminoglycan. Furthermore, 236 patients with lumbar intervertebral disc herniation were treated by target radiofrequency thermocoagulation combined with collagenase chemonucleolysis. The efficiency was evaluated according to Macnab criteria, and the index of lumbar disc herniation (IDH) was compared pre-operation with 3 months post-operation. The post-operative good rate was 66.5% (157/236) at 2 weeks post-operation, and 88.1% (208/236) at 3 months post-operation. In the post-operative follow-up exam, 86.8% of the re-examined cases demonstrated smaller or ablated protrusion, with reduced IDH values from pre-operation, which was statistically significant. No serious complications were detected intra-operatively and post-operatively. In conclusion, target radiofrequency combined with collagenase chemonucleolysis was an effective and safe method for treatment of lumbar intervertebral disc herniation.
authors.affiliation: Department of Pain, The First Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Daying
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Pain, The First Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pain, The First Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Pain, The First Affiliated Hospital of Nanchang University Nanchang 330006, China.
authors.forename: Xuexue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pain, The Third Hospital of Nanchang Nanchang 330009, Jiangxi Province, China.
authors.forename: Mulan
authors.initials: M
authors.lastname: Sheng
keywords: Lumbar intervertebral disc herniation; collagenase chemonucleolysis; radiofrequency