title: From Mice to Men: TRPC3 in Cerebellar Ataxia.
abstract: The dominantly inherited cerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders. Studies using mouse models as well as recent genetic and transcriptomic human findings point to an important role for TRPC3 signaling in cerebellar ataxia.
authors.affiliation: Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Road, Oxford, OX1 3PT, UK. esther.becker@dpag.ox.ac.uk.
authors.forename: Esther B E
authors.initials: EBE
authors.lastname: Becker
mesh_terms: D000818:Animals; D002524:Cerebellar Ataxia / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D050052:TRPC Cation Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D050052:TRPC Cation Channels; C104603:TRPC3 cation channel
keywords: Ataxia; Calcium signaling; Purkinje cell; TRPC3; mGluR1