title: Luminescent ruthenium(II) complex bearing bipyridine and N-heterocyclic carbene-based C∧N∧C pincer ligand for live-cell imaging of endocytosis.
abstract: Luminescent ruthenium(II)-cyanide complex with N-heterocyclic carbene pincer ligand C(∧)N(∧)C = 2,6-bis(1-butylimidazol-2-ylidene)pyridine and 2,2'-bipyridine (bpy) shows minimal cytotoxicity to both human breast carcinoma cell (MCF-7) and human retinal pigmented epithelium cell (RPE) in a wide range of concentration (0.1-500 μM), and can be used for the luminescent imaging of endocytosis of the complex in these cells.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Wai-Kuen
authors.initials: WK
authors.lastname: Tsui
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Lai-Hon
authors.initials: LH
authors.lastname: Chung
authors.affiliation: Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Matthew Man-Kin
authors.initials: MM
authors.lastname: Wong
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Wai-Him
authors.initials: WH
authors.lastname: Tsang
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Hoi-Shing
authors.initials: HS
authors.lastname: Lo
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Yaxiang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon, Hong Kong SAR.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.affiliation: Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Sung-Kay
authors.initials: SK
authors.lastname: Chiu
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR.
authors.forename: Chun-Yuen
authors.initials: CY
authors.lastname: Wong
mesh_terms: D002460:Cell Line; D004705:Endocytosis; D006801:Humans; D008024:Ligands; D049408:Luminescent Agents / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D057054:Molecular Imaging / Q000379:methods; D009942:Organometallic Compounds / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry
chemical_list: D008024:Ligands; D049408:Luminescent Agents; D009942:Organometallic Compounds; C030011:carbene; D012428:Ruthenium; D008697:Methane