title: The association between the -2518A/G polymorphism in the MCP-1 gene and the risk of pulmonary tuberculosis in Sichuan Chinese population.
abstract: OBJECTIVE
  The -2518A/G polymorphism in the Monocyte chemotactic protein-1 (MCP-1) gene may play an important role in regulating immunological reactions and may be associated with pulmonary tuberculosis (PTB). However, the relationship for the populations in Sichuan province of China remains unknown. The objective of the current study was to analysis that association.
  
  
  METHODS
  A total of 386 PTB patients and 398 controls were recruited. The genotypes were identified using PCR-RFLP and sequencing method. Data was analyzed using SPSS 11.0 software.
  
  
  RESULTS
  Significant association was found between the polymorphism and the risk of PTB: AG vs. AA: OR = 1.37, 95% CI = 0.98-1.92 and p = 0.06; GG vs. AA: OR = 1.69, 95% CI = 1.14-2.50 and p = 0.009; AG+GG vs. AA: OR = 1.47, 95% CI = 1.07-2.01 and p = 0.02; G vs. A: OR = 1.31, 95% CI = 1.08-1.60 and p = 0.007.
  
  
  CONCLUSIONS
  The current study suggested that the 2518A/G polymorphism in the MCP-1 gene was associated with risk of PTB in population of Sichuan province in China.
authors.affiliation: West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. yonggang-zhang@sohu.com.
authors.forename: L M
authors.initials: LM
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Tong
authors.forename: X B
authors.initials: XB
authors.lastname: Li
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wu
authors.forename: Y G
authors.initials: YG
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics*
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2