title: Ampicillin Nanoparticles Production via Supercritical CO2 Gas Antisolvent Process.
abstract: The micronization of ampicillin via supercritical gas antisolvent (GAS) process was studied. The particle size distribution was significantly controlled with effective GAS variables such as initial solute concentration, temperature, pressure, and antisolvent addition rate. The effect of each variable in three levels was investigated. The precipitated particles were analyzed with scanning electron microscopy (SEM) and Zetasizer Nano ZS. The results indicated that decreasing the temperature and initial solute concentration while increasing the antisolvent rate and pressure led to a decrease in ampicillin particle size. The mean particle size of ampicillin was obtained in the range of 220-430 nm by varying the GAS effective variables. The purity of GAS-synthesized ampicillin nanoparticles was analyzed in contrast to unprocessed ampicillin by FTIR and HPLC. The results indicated that the structure of the ampicillin nanoparticles remained unchanged during the GAS process.
authors.affiliation: Department of Chemical Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran.|Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
authors.forename: Nadia
authors.initials: N
authors.lastname: Esfandiari
authors.affiliation: Department of Chemical Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran. ghoreshi@cc.iut.ac.ir.
authors.forename: Seyyed M
authors.initials: SM
authors.lastname: Ghoreishi
mesh_terms: D000667:Ampicillin / Q000737:chemistry*; D002245:Carbon Dioxide / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid / Q000379:methods; D005740:Gases / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011312:Pressure; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature
chemical_list: D005740:Gases; D012997:Solvents; D002245:Carbon Dioxide; D000667:Ampicillin
keywords: ampicillin; nanoparticles; precipitation; supercritical gas antisolvent