title: Depression and Risk for Diabetes: A Meta-Analysis.
abstract: OBJECTIVE
  Many studies have reported the relationship between depression and diabetes, but the results have been inconsistent. Our aim was to conduct a systematic review through meta-analysis to assess the association of depression with the risk for developing diabetes.
  
  
  METHODS
  We retrieved the studies concerning depression and the risk for diabetes. Meta-analysis was applied to calculate the combined effect values and their 95% confidence intervals. The risk for publication bias was assessed by the Egger regression asymmetry test.
  
  
  RESULTS
  As many as 33 articles were included in the meta-analysis, for a total of 2 411 641 participants. The pooled relative risk for diabetes was 1.41 (95% CI, 1.25-1.59) for depression, and the combined relative risk for type 2 diabetes mellitus was 1.32 (95% CI, 1.18-1.47).
  
  
  CONCLUSIONS
  Depressed people have a 41% increased risk for developing diabetes mellitus and a 32% increased risk for developing type 2 diabetes. The mechanisms underlying this relationship are still unclear and need further research.
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
authors.forename: Min
authors.initials: M
authors.lastname: Yu
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
authors.forename: Xingliang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lu
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China. Electronic address: lefangchina@yeah.net.
authors.forename: Le
authors.initials: L
authors.lastname: Fang
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D012307:Risk Factors
keywords: depression; diabetes; diabète; dépression; facteurs de risque; meta-analysis; méta-analyse; risk factors