title: Azide-rich peptides via an on-resin diazotransfer reaction.
abstract: Azide-containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide-containing amino acids in solid-phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide-containing residues site-specifically.
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794-3400.
authors.forename: Jeannette E
authors.initials: JE
authors.lastname: Marine
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794-3400.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794-3400.
authors.forename: Shuang
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Chemistry, Stony Brook University, Stony Brook, NY, 11794-3400.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Rudick
mesh_terms: D001386:Azides / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001386:Azides; D010455:Peptides
keywords: azides; bioorthogonal reactions; diazotransfer