title: The potential participation of abdominal pressure in preeclampsia.
abstract: Preeclampsia is a major cause of maternal and perinatal mortality and morbidity. Regardless of susceptibility or predisposing conditions and risk factors, the degree of increase in abdominal pressure is directly related to the severity of preeclampsia, particularly in women with hydatidiform mole. When increased abdominal pressure is normalized by delivery, preeclampsia is cured. Recent genetic studies highlighted two leading risk factors for preeclampsia: chronic renal disease and T235 homozygosity for the AGT gene. Thus, while there is increased abdominal pressure in pregnancy, an imbalanced renin angiotensin system and renal injuries lead to a vicious cycle of increasing abdominal pressure and further renal injuries. A hypothesis for the potential participation of pressure in preeclampsia is described and the amelioration of preeclampsia through postural intervention and the possible therapeutic effect of angiotensin is suggested.
authors.affiliation: GenoTheramics, Corp., 6640 Lusk Blvd, Suite A205A, San Diego, CA 92121, USA; SRHS, 10410 Treena Street, San Diego, CA 92131, USA. Electronic address: Andy@genotheramics.com.
authors.forename: Andy K
authors.initials: AK
authors.lastname: Zhang
mesh_terms: D000005:Abdomen / Q000503:physiopathology*; D000808:Angiotensinogen / Q000235:genetics; D000809:Angiotensins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008954:Models, Biological; D011187:Posture / Q000502:physiology; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy; D011247:Pregnancy; D011312:Pressure / Q000009:adverse effects*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D012307:Risk Factors
chemical_list: C534931:AGT protein, human; D000809:Angiotensins; D000808:Angiotensinogen