title: Should we abandon all conservative treatments for uterine fibroids? The problem with leiomyosarcomas.
abstract: Fibroids are the most common tumor in women and many medical and surgical options exist for their management. The incidence of uterine sarcoma in women undergoing treatment for fibroids has previously been thought to be extremely rare, however there has been recent controversy as to whether this risk has been underestimated. This article reviews the literature investigating the incidence of leiomyosarcoma and explores how different treatment modalities may affect risk from occult malignancy. We aim to provide a tool for counseling women who are considering options for the management of their fibroids.
authors.affiliation: Whipps Cross University Hospital, Barts Health NHS Trust, Leytonstone, London, E11 1NR, UK.
authors.forename: Funlayo
authors.initials: F
authors.lastname: Odejinmi
authors.forename: Nilesh
authors.initials: N
authors.lastname: Agarwal
authors.forename: Kate
authors.initials: K
authors.lastname: Maclaran
authors.forename: Reeba
authors.initials: R
authors.lastname: Oliver
mesh_terms: D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D015994:Incidence; D010535:Laparoscopy / Q000009:adverse effects; D007889:Leiomyoma / Q000150:complications* / Q000628:therapy*; D007890:Leiomyosarcoma / Q000209:etiology* / Q000473:pathology; D000069577:Morcellation / Q000009:adverse effects; D055357:Uterine Artery Embolization / Q000009:adverse effects; D014594:Uterine Neoplasms / Q000209:etiology* / Q000473:pathology; D016387:Women's Health
chemical_list: D007987:Gonadotropin-Releasing Hormone
keywords: fibroids; hysterectomy; laparoscopy; leiomyomosarcoma; morcellation; myomectomy