title: LAMB1 polymorphism is associated with autism symptom severity in Korean autism spectrum disorder patients.
abstract: BACKGROUND
  LAMB1 encodes laminin beta-1, which is expressed during early development of the human nervous system, and could be involved in the pathogenesis of neurodevelopmental disorders.
  
  
  OBJECTIVE
  In our study, we aimed to investigate whether single nucleotide polymorphisms (SNPs) in LAMB1 were associated with autism spectrum disorder (ASD) and with related clinical severities of ASD.
  
  
  METHODS
  Two coding SNPs (rs20556 and rs25659) and two intronic SNPs (rs2158836 and rs2237659) were compared between 180 patients with ASD and 147 healthy control subjects using direct sequencing. The Korean version of the Childhood Autism Rating Scale (K-CARS) was used to assess clinical severities. Multiple logistic regression models were employed to analyze genetic data, and associations with symptom severity were tested with the Kruskal-Wallis and the Mann-Whitney U tests.
  
  
  RESULTS
  None of the four examined SNPs was associated with ASD risk. However, the GG genotype of rs2158836 was associated with more severe symptoms for the "object use" and "non-verbal communication" measures.
  
  
  CONCLUSIONS
  The results of our study suggest the association between rs2158836 polymorphisms and symptom severity in ASD.
authors.affiliation: a Young Jong Kim, Department of Neuropsychiatry , School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Young Jong
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: b Jin Kyung Park, Department of Neuropsychiatry , School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Park
authors.affiliation: c Won Sub Kang, Department of Neuropsychiatry , School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Won Sub
authors.initials: WS
authors.lastname: Kang
authors.affiliation: d Su Kang Kim, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Su Kang
authors.initials: SK
authors.lastname: Kim
authors.affiliation: e Hae Jeong Park, Kohwang Medical Research Institute, School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Hae Jeong
authors.initials: HJ
authors.lastname: Park
authors.affiliation: f Min Nam, Seoul Metropolitan Eunpyeong Hospital , 90 Baeknyeonsan-ro, Eunpyeong-gu, Seoul 122-913, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Nam
authors.affiliation: g Jong Woo Kim, Department of Neuropsychiatry , School of Medicine, Kyung Hee University , Seoul 130-701 , Republic of Korea.
authors.forename: Jong Woo
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D007797:Laminin / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012720:Severity of Illness Index
chemical_list: C478221:LAMB1 protein, human; D007797:Laminin
keywords: Autism spectrum disorder; Childhood Autism Rating Scale; LAMB1