title: Copper-catalyzed radical reaction of N-tosylhydrazones: stereoselective synthesis of (E)-vinyl sulfones.
abstract: A new chemistry of hydrazines that is a copper-catalyzed radical reaction to synthesize vinyl sulfones from readily available N-tosylhydrazones has been described. The protocol provides a novel strategy for the synthesis of various vinyl sulfones including α, β-disubstituted ones and terminal ones. The advantages of the transformation include excellent E stereoselectivity, broad substrate scope, low cost of reagents, and convenient operation. A novel and efficient one-pot synthesis of alkynes from N-tosylhydrazones has been achieved. The studies provide important complementary approaches for the syntheses of vinyl sulfones and alkynes.
authors.forename: Shuai
authors.initials: S
authors.lastname: Mao
authors.forename: Ya-Ru
authors.initials: YR
authors.lastname: Gao
authors.forename: Xue-Qing
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Guo
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Wang