title: Ischemic postconditioning in cerebral ischemia: Differences between the immature and mature brain?
abstract: Ischemic postconditioning (postC), defined as serial mechanical interruptions of blood flow at reperfusion, effectively reduces myocardial infarct size in all species tested so far, including humans. In the brain, ischemic postC leads to controversial results regardless of variations in factors such as onset time of beginning, the duration of ischemia and/or reperfusion, and the number of cycles of occlusion/reperfusion. Thus, many major issues remain to be resolved regarding its protective effects. Future studies should aim to identify the parameters that yield the strongest protection, as well as to understand why the efficacy of ischemic postC differs between models. This review will focus on initial hemodynamic changes and their consequences, and on specific features such as NO-dependent vascular tone and/or prolonged acidosis in cerebral ischemia-reperfusion in order to better understand the dynamics of ischemic postC in the developing brain.
authors.affiliation: Univ. Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1141, 75019 Paris, France; PremUp Foundation, 75006 Paris, France; UPMC-Paris6, AP-HP, Hôpital Armand Trousseau, Service de Réanimation Néonatale et Pédiatrique, 75012 Paris, France.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Leger
authors.affiliation: Univ. Paris Diderot, Sorbonne Paris Cité, AP-HP, Hôpital Lariboisière, Physiologie Clinique, Explorations-Fonctionnelles, 75010 Paris, France; Univ. Paris Diderot, Sorbonne Paris Cité, INSERM, U965, 75010 Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonnin
authors.affiliation: Univ. Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1141, 75019 Paris, France; Univ. Paris Descartes, AP-HP, CHU Necker-Enfants Malades, Réanimation et USC médico-chirurgicales pédiatriques, 75015 Paris, France.
authors.forename: Sylvain
authors.initials: S
authors.lastname: Renolleau
authors.affiliation: Univ. Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1141, 75019 Paris, France; PremUp Foundation, 75006 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Baud
authors.affiliation: Univ. Paris Diderot, Sorbonne Paris Cité, INSERM UMR 1141, 75019 Paris, France; PremUp Foundation, 75006 Paris, France. Electronic address: christiane.marlangue@gmail.com.
authors.forename: Christiane
authors.initials: C
authors.lastname: Charriaut-Marlangue
mesh_terms: D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D002560:Cerebrovascular Circulation; D019317:Evidence-Based Medicine; D006801:Humans; D007231:Infant, Newborn; D057775:Ischemic Postconditioning / Q000379:methods*; D016896:Treatment Outcome
keywords: Acidosis; Collateral recruitment; Hyperemia; NO-dependent vascular tone; Reperfusion