title: Inverse association of des-acyl ghrelin with worksite blood pressure in overweight/obese male workers.
abstract: BACKGROUND
  Job strain, defined as a combination of high job demands and low job control, has been reported to elevate blood pressure (BP) during work. Meanwhile, a recent experimental study showed that ghrelin blunted the BP response to such mental stress. In the present study, we examined the hypothesis that des-acyl ghrelin may have some beneficial effects on worksite BP through modulating the BP response to work-related mental stress, i.e., job strain.
  
  
  METHODS
  Subjects were 34 overweight/obese male day-shift workers (mean age 41.7 ± 6.7 years). No subjects had received any anti-hypertensive medication. A 24-h ambulatory BP monitoring was recorded every 30 min on a regular working day. The average BP was calculated for Work BP, Morning BP, and Home BP. Job strain was assessed using the short version of the Japanese Job Content Questionnaire.
  
  
  RESULTS
  Des-acyl ghrelin showed significant inverse correlations with almost all BPs except Morning SBP, Morning DBP, and Home DBP. In multiple regression analysis, des-acyl ghrelin inversely correlated with Work SBP after adjusting for confounding factors. Des-acyl ghrelin was also negatively associated with BP changes from Sleep to Morning, Sleep to Work, and Sleep to Home.
  
  
  CONCLUSIONS
  Des-acyl ghrelin was inversely associated with Worksite BP, suggesting a unique beneficial effect of des-acyl ghrelin on Worksite BP in overweight/obese male day-shift workers.
authors.affiliation: Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan, akihikonarisada@yahoo.co.jp.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Narisada
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Maki
authors.initials: M
authors.lastname: Nakahigashi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hirobe
authors.forename: Tatsunori
authors.initials: T
authors.lastname: Ikemoto
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ushida
authors.forename: Fumio
authors.initials: F
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D050177:Overweight / Q000453:epidemiology* / Q000209:etiology; D012044:Regression Analysis; D017132:Workplace
chemical_list: D054439:Ghrelin; C422650:ghrelin, des-n-octanoyl