title: Occult cancer in specimens of reduction mammaplasty aimed at symmetrization. A multicentric study of 2718 patients.
abstract: Women who have undergone surgical treatment for breast cancer often benefit from a contralateral reduction mammaplasty (CRM) aimed at symmetrization of the contralateral breast unaffected by the initial cancer. In our 7-year multicentric study (12 centers) of 2718 patients, incidence of CRM cancers (CRMc) was 1.47% (n = 40) [95% CI 1.05%-2.00%]. The CRMc group had significantly more initial mammary cancers of invasive lobular carcinoma (ILC, 22.5% vs 12.0%) and ductal carcinoma in situ (DCIS, 35.0% vs 21.6%) types than the healthy CRM group (p = 0.017). 35.0% (n = 14) of patients had en bloc resection; 25.0% (n = 10) of surgical specimens were correctly oriented. En bloc resection and orientation of surgical specimens enable precise pinpointing of the CRMc. A salvage lumpectomy may be proposed as an option when margins are invaded. The histological distribution of the 40 CRMc (mean size 12.7 mm) was carcinoma in situ (CIS) 70%, ILC 12.5%, invasive ductal carcinoma (IDC) 12.5% and tubular carcinoma (TC) 5.0%.
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France; Service de Chirurgie Plastique et Maxillo-Faciale - CHU de Nancy, Hôpital Central, 29 Avenue du Maréchal de Lattre de Tassigny, 54000 Nancy, France. Electronic address: t.sorin@chu-nancy.fr.
authors.forename: T
authors.initials: T
authors.lastname: Sorin
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Fyad
authors.affiliation: Centre de Cancérologie Léon Bérard, 28 rue Laennec, 69008 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Delay
authors.affiliation: Institut de Cancérologie de Montpellier, 208 rue des Apothicaires, 34298 Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Rouanet
authors.affiliation: Institut de Cancérologie Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Rimareix
authors.affiliation: Centre de Cancérologie Oscar Lambret, 3 rue Frédéric Combemale, 59020 Lille, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Houpeau
authors.affiliation: Institut de Cancérologie de l'Ouest - René Gauducheau, Boulevard Jacques Monod, 44805 Saint-Herblain, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Classe
authors.affiliation: Institut de Cancérologie Claudius Regaud, 20-24 Rue du Pont Saint-Pierre, 31300 Toulouse, France.
authors.forename: I
authors.initials: I
authors.lastname: Garrido
authors.affiliation: Institut de Cancérologie Bergonié, 229 Cours de l'Argonne, 33000 Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Tunon De Lara
authors.affiliation: Centre de Cancérologie Jean Perrin, 58 rue Montalembert, 63011 Clermont Ferrand, France.
authors.forename: J
authors.initials: J
authors.lastname: Dauplat
authors.affiliation: Centre de Cancérologie Eugène Marquis, avenue de la Bataille Flandres-Dunkerque, 35042 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Bendavid
authors.affiliation: Institut de Cancérologie Paoli Calmettes, 232 boulevard de Sainte Margueritte, 13273 Marseille, France.
authors.forename: G
authors.initials: G
authors.lastname: Houvenaeghel
authors.affiliation: Institut du Sein, 7 avenue Bugeaud, 75116 Paris, France.
authors.forename: K B
authors.initials: KB
authors.lastname: Clough
authors.affiliation: Institut du Sein, 7 avenue Bugeaud, 75116 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Sarfati
authors.affiliation: Institut de Cancérologie Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif, France.
authors.forename: N
authors.initials: N
authors.lastname: Leymarie
authors.affiliation: Centre de Cancérologie Oscar Lambret, 3 rue Frédéric Combemale, 59020 Lille, France.
authors.forename: M
authors.initials: M
authors.lastname: Trudel
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: J
authors.initials: J
authors.lastname: Salleron
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: F
authors.initials: F
authors.lastname: Guillemin
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Oldrini
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France; Service de Chirurgie Plastique et Maxillo-Faciale - CHU de Nancy, Hôpital Central, 29 Avenue du Maréchal de Lattre de Tassigny, 54000 Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Brix
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: G
authors.initials: G
authors.lastname: Dolivet
authors.affiliation: Service de Chirurgie Plastique et Maxillo-Faciale - CHU de Nancy, Hôpital Central, 29 Avenue du Maréchal de Lattre de Tassigny, 54000 Nancy, France.
authors.forename: E
authors.initials: E
authors.lastname: Simon
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Verhaeghe
authors.affiliation: Institut de Cancérologie de Lorraine - Alexis Vautrin, 6 Avenue de Bourgogne, 54519 Vandœuvre-lès-Nancy, France; CRAN - UMR 7039, Université de Lorraine, CNRS, France.
authors.forename: F
authors.initials: F
authors.lastname: Marchal
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000453:epidemiology* / Q000556:secondary / Q000601:surgery; D018275:Carcinoma, Lobular / Q000453:epidemiology* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D015994:Incidence; D016462:Mammaplasty / Q000706:statistics & numerical data*; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000453:epidemiology*; D012189:Retrospective Studies
keywords: Breast neoplasms; Breast reconstruction; Incidence study; Mammoplasty; Reconstructive surgical procedures