title: A dehydrogenative cross-coupling reaction between aromatic aldehydes or ketones and dialkyl H-phosphonates for formyl or acylphenylphosphonates.
abstract: A novel DCC reaction between aromatic aldehydes or ketones and H-phosphonates has been developed for the synthesis of p-formyl or p-acylphenylphosphonates. The synthetic method has excellent para regioselectivities, good yields, and broad substrate scopes and is more benign to the environment. The DCC reaction also tolerates many functional groups, and results in a series of new p-formyl and p-acylphenylphosphonates, which should be important building blocks for the synthesis of versatile arylphosphonate derivatives.
authors.affiliation: Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, P. R. China.
authors.forename: Xing-Fen
authors.initials: XF
authors.lastname: Huang
authors.forename: Qing-Lai
authors.initials: QL
authors.lastname: Wu
authors.forename: Jian-Shi
authors.initials: JS
authors.lastname: He
authors.forename: Zhi-Zhen
authors.initials: ZZ
authors.lastname: Huang
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D005561:Formates / Q000138:chemical synthesis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D005561:Formates; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D063065:Organophosphonates