title: [Distribution of intraductal carcinoma of the prostate and associated lesions in the cancer foci on radical prostatectomy specimens].
abstract: OBJECTIVE
  The distribution of intraductal carcinoma of the prostate (IDC-P) and other intraductal lesions associated with IDC-P was evaluated in the cancer foci on radical prostatectomy specimens.
  
  
  METHODS
  We reviewed slide in 412 cases treated by radical prostatectomy without neoadjuvant therapy. Mapping study was performed with regard to IDC-P, other intraductal lesions associated with IDC-P and invasive carcinoma.
  
  
  RESULTS
  We identified 98 cases (23.8%) and 102 cancer foci associated with IDC-P. In these all cancer foci, IDC-P was associated with invasive carcinoma and other intraductal neoplastic lesions with tufting, micropapillary and loose cribriform patterns were contiguous and admixed with IDC-P in 83 cancer foci (81.4%). There were lesions with invasive carcinoma around the IDC-P in 95 cancer foci (93.1%) and lesions without invasive carcinoma around IDC-P in 66 foci (64.7%). The latter lesions existed in the marginal areas of the cancer foci in 63 (61.8%) and in the central areas of the cancer foci in 14 (13.7%). In 5 cancer foci (4.9%), volume of IDC-P was larger than that of invasive carcinoma.
  
  
  CONCLUSIONS
  The distribution of IDC-P with dense cribriform and solid patterns varied in cancer foci, and intraductal lesions with tufting, micropapillary and loose cribriform patterns were frequently seen in area contiguous and admixed with IDC-P. The latter lesion may be low grade morphology of IDC-P, although the lesions could not be distinguished from high grade prostatic intraepithelial neoplasia.
authors.forename: Naotaka
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Tomoko
authors.initials: T
authors.lastname: Maki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masumitsu
authors.initials: M
authors.lastname: Hamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iguchi
authors.forename: Seiya
authors.initials: S
authors.lastname: Momosaki
authors.forename: Yoshifuku
authors.initials: Y
authors.lastname: Nakayama
mesh_terms: D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology*