title: [Low expression of succinate dehydrogenase subunit B in locally recurrent nasopharyngeal carcinoma and implication for prognosis].
abstract: OBJECTIVE
  To study the expression of succinate dehydrogenase subunit B (SDHB) in the tissues of locally recurrent nasopharyngeal carcinoma (rNPC) and the correlation with the clinicopathological factors and prognosis of rNPC.
  
  
  METHODS
  Immunohistochemistry was used to detect the expression of SDHB in the tissues of primary and locally recurrent nasopharyngeal carcinoma. The relationship between SDHB expression and clinicopathological features was analyzed using the Chi-square test, and Kaplan-Meier method and Log-rank test were used for survival analysis. The independent prognostic factors of rNPC were analyzed by Cox regression model.
  
  
  RESULTS
  Low SDHB expression was showed in 76.5% (39/51) of the patients with rNPC, significantly higher than 57.1% (24/42) of primary nasopharyngeal carcinoma (χ(2) = 4.098, P < 0.05). Low expression of SDHB strongly was correlated with T classification, clinical stage and cranial nerve palsy. Patients with low SDHB expression had a shorter survival time and a lower 3 or 5 year survival rate compared to the patients with high SDHB expression. Multivariate analysis showed that low SDHB expression was an independent predictor for overall survival of patients with rNPC (P < 0.05).
  
  
  CONCLUSIONS
  The low SDHB expression is an independent indicator for poor prognosis of rNPC and may play an important role in the recurrence of rNPC.
authors.affiliation: Department of Otorhinolaryngology, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou 325200, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Lin
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Dai
authors.forename: Chongxi
authors.initials: C
authors.lastname: Chen
authors.forename: Shenghua
authors.initials: S
authors.lastname: Pan
authors.affiliation: Department of Otorhinolaryngology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Email:liaozhisu111@163.com.
authors.forename: Zhisu
authors.initials: Z
authors.lastname: Liao
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma; D006801:Humans; D007150:Immunohistochemistry; D015999:Multivariate Analysis; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D013385:Succinate Dehydrogenase