title: Generation of electrospun nanofibers with controllable degrees of crimping through a simple, plasticizer-based treatment.
abstract: Electrospun nanofibers with controllable degrees of crimping are fabricated by simply exposing the samples to a plasticizer at preset shrinkage ratios. Compared with their straight counterparts, the crimped nanofibers are able to mechanically mimic native tendon tissue and better protect tendon fibroblasts under uniaxial strains.
authors.affiliation: School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
authors.forename: Wenying
authors.initials: W
authors.lastname: Liu
authors.forename: Justin
authors.initials: J
authors.lastname: Lipner
authors.forename: Christine H
authors.initials: CH
authors.lastname: Moran
authors.forename: Liangzhu
authors.initials: L
authors.lastname: Feng
authors.forename: Xiyu
authors.initials: X
authors.lastname: Li
authors.forename: Stavros
authors.initials: S
authors.lastname: Thomopoulos
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002470:Cell Survival; D004126:Dimethylformamide / Q000737:chemistry; D055119:Elastic Modulus; D000431:Ethanol / Q000737:chemistry; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D019344:Lactic Acid / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D010968:Plasticizers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry; D013059:Spectrum Analysis, Raman; D013710:Tendons / Q000166:cytology / Q000502:physiology; D054457:Tissue Scaffolds; D005465:Fluorocarbon Polymers
chemical_list: D004126:Dimethylformamide; D000431:Ethanol; D019344:Lactic Acid; D010968:Plasticizers; D011091:Polyesters; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011145:Polyvinyls; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers; C016240:polycaprolactone; C033616:poly(lactide)
keywords: crimping; electrospun nanofibers; plasticizer; scaffold; tendon tissue engineering