title: Plasma membrane-associated platforms: dynamic scaffolds that organize membrane-associated events.
abstract: Specialized regions of the plasma membrane dedicated to diverse cellular processes, such as vesicle exocytosis, extracellular matrix remodeling, and cell migration, share a few cytosolic scaffold proteins that associate to form large plasma membrane-associated platforms (PMAPs). PMAPs organize signaling events and trafficking of membranes and molecules at specific membrane domains. On the basis of the intrinsic disorder of the proteins constituting the core of these PMAPs and of the dynamics of these structures at the periphery of motile cells, we propose a working model for the assembly and turnover of these platforms.
authors.affiliation: San Raffaele University and San Raffaele Scientific Institute, Cell Adhesion Laboratory, via Olgettina 58, 20132 Milano, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Astro
authors.affiliation: San Raffaele University and San Raffaele Scientific Institute, Cell Adhesion Laboratory, via Olgettina 58, 20132 Milano, Italy. decurtis.ivan@hsr.it.
authors.forename: Ivan
authors.initials: I
authors.lastname: de Curtis
mesh_terms: D021961:Cell Membrane Structures / Q000378:metabolism / Q000502:physiology*; D022083:Cytoplasmic Structures / Q000378:metabolism / Q000502:physiology*; D005089:Exocytosis / Q000235:genetics / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D022001:Focal Adhesions / Q000378:metabolism; D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D016326:Extracellular Matrix Proteins; D064267:Intrinsically Disordered Proteins; D026901:Membrane Transport Proteins