title: Familial colorectal cancer syndromes: an overview of clinical management.
abstract: Familial colorectal cancer syndromes pose a complex challenge to the treating clinician. Once a syndrome is recognized, genetic testing is often required to confirm the clinical suspicion. Management from that point is usually based on disease-specific guideline recommendations targeting risk reduction for the patient and their relatives through surgery, surveillance and chemoprophylaxis. The aim of this paper is to provide an up-to-date summary of the most common familial syndromes and their medical and surgical management, with specific emphasis on evidence-based interventions that improve patient outcome, and to present the information in a manner that is easily readable and clinically relevant to the treating clinician.
authors.affiliation: Colorectal Surgery Unit, Department of Surgery, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
authors.forename: Tarik
authors.initials: T
authors.lastname: Sammour
authors.forename: Ian P
authors.initials: IP
authors.lastname: Hayes
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Hill
authors.forename: Finlay A
authors.initials: FA
authors.lastname: Macrae
authors.forename: Des C
authors.initials: DC
authors.lastname: Winter
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D014408:Biomarkers, Tumor / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D040941:Heredity; D006801:Humans; D044483:Intestinal Polyposis / Q000151:congenital* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010375:Pedigree; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010641:Phenotype; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Lynch; adenoma; colorectal cancer; familial; polyposis