title: Aging-related systemic manifestations in COPD patients and cigarette smokers.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease (COPD) is often associated with age-related systemic abnormalities that adversely affect the prognosis. Whether these manifestations are linked to the lung alterations or are independent complications of smoking remains unclear.
  
  
  OBJECTIVE
  To look for aging-related systemic manifestations and telomere shortening in COPD patients and smokers with minor lung destruction responsible for a decline in the diffusing capacity for carbon monoxide (DLCO) corrected for alveolar volume (KCO).
  
  
  METHODS
  Cross-sectional study in 301 individuals (100 with COPD, 100 smokers without COPD, and 101 nonsmokers without COPD).
  
  
  RESULTS
  Compared to control smokers, patients with COPD had higher aortic pulse-wave velocity (PWV), lower bone mineral density (BMD) and appendicular skeletal muscle mass index (ASMMI), and shorter telomere length (TL). Insulin resistance (HOMA-IR) and glomerular filtration rate (GFR) were similar between control smokers and COPD patients. Smokers did not differ from nonsmokers for any of these parameters. However, smokers with normal spirometry but low KCO had lower ASMMI values compared to those with normal KCO. Moreover, female smokers with low KCO, had lower BMD and shorter TL compared to those with normal KCO.
  
  
  CONCLUSIONS
  Aging-related abnormalities in patients with COPD are also found in smokers with minor lung dysfunction manifesting as a KCO decrease. Decreased KCO might be useful, particularly among women, for identifying smokers at high risk for aging-related systemic manifestations and telomere shortening.
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France; INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Boyer
authors.affiliation: INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France; Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Christos
authors.initials: C
authors.lastname: Chouaïd
authors.affiliation: APHP, Hôpital Henri Mondor, Département de Santé Publique, F-94010, Créteil, France; Université Paris Est (UPEC), Faculté de médecine, LIC, EA4393, F-94010, Créteil, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Bastuji-Garin
authors.affiliation: Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Marcos
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Margarit
authors.affiliation: INSERM, Centre d'Investigation Clinique 1430, AP-HP, Hôpital Henri Mondor, F-94010, Créteil, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Corvoisier
authors.affiliation: INSERM, Centre d'Investigation Clinique 1430, AP-HP, Hôpital Henri Mondor, F-94010, Créteil, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Vervoitte
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France.
authors.forename: Leila
authors.initials: L
authors.lastname: Hamidou
authors.affiliation: APHP, Hôpital Henri-Mondor, Département d'Addictologie, F-94010, Créteil, France.
authors.forename: Lamia
authors.initials: L
authors.lastname: Frih
authors.affiliation: APHP, Hôpital Henri Mondor, Département de Santé Publique, F-94010, Créteil, France; Université Paris Est (UPEC), Faculté de médecine, LIC, EA4393, F-94010, Créteil, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Audureau
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France.
authors.forename: Ala
authors.initials: A
authors.lastname: Covali-Noroc
authors.affiliation: Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Andujar
authors.affiliation: Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Saakashvili
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Lino
authors.affiliation: APHP, Hôpital Henri Mondor, Plateforme de Ressources Biologiques, F-94010, Créteil, France.
authors.forename: Bijan
authors.initials: B
authors.lastname: Ghaleh
authors.affiliation: APHP, Hôpital Henri Mondor, Département d'Immunologie Biologique, F-94010, Créteil, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Hue
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France; INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Derumeaux
authors.affiliation: Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Housset
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Cardiologie, F-94010, Créteil, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Dubois-Randé
authors.affiliation: INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France.
authors.forename: Jorge
authors.initials: J
authors.lastname: Boczkowski
authors.affiliation: INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France; Centre Hospitalier Intercommunal, DHU-ATVB, Département de Pneumologie et Pathologie Professionnelle, F-94000, Créteil, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Maitre
authors.affiliation: APHP, Hôpital Henri Mondor, DHU-ATVB, Département de Physiologie-Explorations Fonctionnelles, F-94010, Créteil, France; INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de médecine, F-94010, Créteil, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Adnot
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011650:Pulmonary Alveoli / Q000473:pathology / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry; D016615:Telomere / Q000235:genetics
chemical_list: D016207:Cytokines