title: [Clinical outcomes after combined therapy with dutasteride in patients with unsuccessful trial without catheter after treatment with an alpha1-adrenergic receptor blocker monotherapy for acute urinary retention caused by prostatic hyperplasia].
abstract: OBJECTIVE
  The outcome of trial of voiding without catheter in patients treated combination therapy with dutasteride and alpha1-adrenergic receptor blocker for acute urinary retention caused by benign prostatic hyperplasia was not reported. We evaluated the clinical efficacy of combination therapy with dutasteride in patients with unsuccessful trial without catheter after treatment with an alpha1-adrenergic receptor blocker monotherapy for acute urinary retention caused by benign prostatic hyperplasia.
  
  
  METHODS
  Patients with acute urinary retention due to prostatic hyperplasia were catheterized and treated alpha1-adrenergic receptor blocker monotherapy. After two weeks later, patients were put on trial without catheter. 52 patients who were unsuccessful trial without catheter administered combination therapy with dutasteride and alpha1-adrenergic receptor blocker. We use criteria that voiding urine volume over 100 ml and post-void residual urine volume below 100 ml in deciding whether catheter should be removed.
  
  
  RESULTS
  33 (63.5%) men did not require re-catheterization within 7 months after combination therapy. The successful rate of Performance Status (PS) 0-1 group was significantly superior to that of PS 2-4 group.
  
  
  CONCLUSIONS
  PS 0-1 men catheterized for AUR can void more successfully after catheter removal than PS 2-4 men if treated with combination therapy.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inahara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugiura
authors.forename: Kanya
authors.initials: K
authors.lastname: Kaga
authors.forename: Kyokusin
authors.initials: K
authors.lastname: Hou
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Araki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masuda
authors.forename: Satoko
authors.initials: S
authors.lastname: Kojima
authors.forename: Yukio
authors.initials: Y
authors.lastname: Naya
mesh_terms: D000208:Acute Disease; D058668:Adrenergic alpha-1 Receptor Antagonists / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D001378:Azasteroids / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D000068538:Dutasteride; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000150:complications*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017211:Treatment Failure; D016896:Treatment Outcome; D062885:Urinary Catheters; D016055:Urinary Retention / Q000188:drug therapy* / Q000209:etiology*; D064804:Urological Agents / Q000008:administration & dosage*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D001378:Azasteroids; D064804:Urological Agents; D000068538:Dutasteride