title: Current concepts in premature ovarian insufficiency.
abstract: Premature ovarian insufficiency (POI) is a life-changing diagnosis, with profound physical and psychological consequences. Unfortunately, there are many deficiencies in our understanding of the condition as the underlying etiology and optimum management strategies are poorly understood. Improved awareness of POI and its long-term implications has led to increased research interest in recent years. Current research has allowed a greater understanding of the changing epidemiology in POI, genetic factors in its etiology and randomized controlled trials of hormone therapy are underway to provide evidence for treatment. This article reviews the latest literature on POI to summarize current understanding and future directions.
authors.affiliation: West Middlesex University Hospital NHS Trust, Twickenham Road, Isleworth, Middlesex TW7 6AF, UK.
authors.forename: Kate
authors.initials: K
authors.lastname: Maclaran
authors.forename: Nick
authors.initials: N
authors.lastname: Panay
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000008:administration & dosage; D001828:Body Image; D041321:Chromosomes, Human, X; D003937:Diagnosis, Differential; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007239:Infections / Q000150:complications; D007247:Infertility, Female / Q000209:etiology; D008603:Mental Health; D065851:Ovarian Reserve / Q000502:physiology; D016649:Primary Ovarian Insufficiency / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology* / Q000628:therapy; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000209:etiology; D016387:Women's Health
chemical_list: D000728:Androgens
keywords: hormone therapy; ovarian reserve; premature menopause; premature ovarian failure; premature ovarian insufficiency; primary ovarian insufficiency; sex steroid deficiency