title: Role of NF-κB/IKK-dependent signaling in functional stimulation of mesenchymal progenitor cells by alkaloid songorine.
abstract: We studied the role of NF-κB/IKK-mediated signaling in the stimulation of growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Specific NF-κB inhibitor oridonin abolished activation of proliferation and differentiation of progenitor cells. Aurothiomalate, a selective blocker of IKK-2, also suppressed mitotic activity of fibroblast precursors, but had no effect on the rate of the differentiation.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, zgn@pharm.tsu.ru.
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: V P
authors.initials: VP
authors.lastname: Demkin
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: E E
authors.initials: EE
authors.lastname: Shults
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D045786:Diterpenes, Kaurane / Q000494:pharmacology; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D044968:Regenerative Medicine
chemical_list: D000470:Alkaloids; D045786:Diterpenes, Kaurane; D016328:NF-kappa B; C011959:oridonin; D006052:Gold Sodium Thiomalate; C057217:songorine; D051550:I-kappa B Kinase; C496562:Ikbkb protein, mouse