title: P-selectin-mediated platelet adhesion promotes tumor growth.
abstract: Blood platelets foster carcinogenesis. We found that platelets are accumulated in human tumors. P-selectin deficiency and soluble P-selectin abolish platelet deposition within tumors, decreasing secretion of vascular endothelial growth factor and angiogenesis, thereby suppressing tumor growth. Binding of the P-selectin cytoplasmic tail to talin1 triggers the talin1 N-terminal head to interact with the β3 cytoplasmic tail. This activates αIIbβ3 and recruits platelets into tumors. Platelet infiltration into solid tumors occurs through a P-selectin-dependent mechanism.
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Qi
authors.affiliation: Department of Gastrointestinal Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wei
authors.affiliation: Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA.
authors.forename: Weijie
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Simei
authors.initials: S
authors.lastname: Guo
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Li
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ye
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Jiangchao
authors.initials: J
authors.lastname: Li
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Lan
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: He
authors.affiliation: Key Laboratory of Medical Cell Biology, China Medical University, Shen Yang City, Liao Ning Province 110001, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Cao
authors.affiliation: Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109, USA.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Geng
authors.affiliation: Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007340:Insulinoma / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008546:Melanoma, Experimental / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019007:P-Selectin / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010973:Platelet Adhesiveness; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction; D016608:Talin; D013997:Time Factors; D047368:Tumor Burden
chemical_list: D019007:P-Selectin; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C546937:SELP protein, human; D016608:Talin; C496077:Tln1 protein, mouse
keywords: P-selectin; platelets; talin1; tumor growth; αIIbβ3