title: In vitro biocompatibility evaluation of bioresorbable copolymers prepared from L-lactide, 1, 3-trimethylene carbonate, and glycolide for cardiovascular applications.
abstract: PLLA-TMC-GA terpolymer was prepared by ring-opening polymerization of L-lactide, 1, 3-trimethylene carbonate (TMC), and glycolide (GA). The biocompatibility of terpolymer was evaluated in comparison with PLLA and PLLA-TMC with the aim of assessing their potential in the development of bioresorbable cardiovascular stents. Various aspects of in vitro biocompatibility were considered, including MTT assay, hemolytic test, dynamic clotting time, platelet adhesion, platelet activation, protein adsorption, plasma recalcification time and release of cytokines. The results revealed that the terpolymer presents good cytocompatibility and hemocompatibility. Moreover, no significant increase in the release of cytokines was detected. It is thus concluded that these polymers, in particular PLLA-TMC-GA terpolymer present good biocompatibility for cardiovascular applications.
authors.affiliation: a Department of Pharmaceutical Engineering , College of Chemical Engineering, Qingdao University of Science and Technology , Qingdao 266042 , China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shen
authors.forename: Feng
authors.initials: F
authors.lastname: Su
authors.forename: Jianting
authors.initials: J
authors.lastname: Dong
authors.forename: Zhongyong
authors.initials: Z
authors.lastname: Fan
authors.forename: Yourong
authors.initials: Y
authors.lastname: Duan
authors.forename: Suming
authors.initials: S
authors.lastname: Li
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001807:Blood Vessel Prosthesis; D002318:Cardiovascular Diseases / Q000628:therapy*; D002478:Cells, Cultured; D004146:Dioxanes / Q000737:chemistry* / Q000494:pharmacology; D006016:Glycolates / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D015607:Stents; D062666:Vascular Access Devices
chemical_list: D001672:Biocompatible Materials; D004146:Dioxanes; D006016:Glycolates; D011091:Polyesters; D011108:Polymers; C031149:glycolic acid; D019344:Lactic Acid; C443643:trimethylene carbonate; C033616:poly(lactide)
keywords: biocompatibility; bioresorbable; cardiovascular stent; poly (trimethylene carbonate); polyglycolide; polylactide