title: CASP7 variants modify susceptibility to cervical cancer in Chinese women.
abstract: Polymorphisms in Caspase-7 (CASP7) may modulate the programmed cell death and thus contribute to cervical cancer risk. In this case-control study of 1,486 cervical cancer cases and 1,301 controls, we investigated associations between four potentially functional polymorphisms in CASP7 and cervical cancer risk and evaluated their locus-locus interaction effects on the risk. The genotype-phenotype correlation was performed by a generalized linear regression model. We found that the rs4353229 polymorphism was associated with cervical cancer risk (under a recessive model: crude OR = 1.20, 95% CI = 1.02-1.40). Compared with the TT genotype, the rs10787498GT genotype was associated with an increased cervical cancer risk (adjusted OR = 1.19, 95% CI = 1.00-1.41). Combination analysis showed that subjects with four putative risk genotypes had a 1.54-fold increased cancer risk, compared with those who carried three or less putative risk genotypes. We also observed significant locus-locus joint effects on the risk, which may be mediated by the polymorphisms regulating CASP7 mRNA expression. Subsequent multifactor dimensionality reduction and classification and regression tree analyses indicated that the CASP7 genotypes might have a locus-locus interaction effect that modulated cervical cancer risk. Out data suggest that CASP7 polymorphisms may interact to modify cervical cancer risk by a possible mechanism of regulating CASP7 mRNA expression.
authors.affiliation: 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2] Department of Obstetrics and Gynecology, Zhongshan Hospital Fudan University, Shanghai 200032, China.
authors.forename: Ting-Yan
authors.initials: TY
authors.lastname: Shi
authors.affiliation: 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2] State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Meng-Yun
authors.initials: MY
authors.lastname: Wang
authors.affiliation: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Zhu
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Ke-Da
authors.initials: KD
authors.lastname: Yu
authors.affiliation: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Shao
authors.affiliation: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Meng-Hong
authors.initials: MH
authors.lastname: Sun
authors.affiliation: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Cheng
authors.affiliation: 1] Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China [2] Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D053179:Caspase 7 / Q000235:genetics* / Q000378:metabolism; D002681:China; D004198:Disease Susceptibility; D005260:Female; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology
chemical_list: D012333:RNA, Messenger; D053179:Caspase 7