title: Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.
abstract: Parallel affinity screening of a DNA-encoded chemical library against rat, bovine and human serum albumin allowed the identification of small-molecule ligands with distinctive binding specificities to the individual proteins.
authors.affiliation: Institute of Pharmaceutical Sciences, ETH Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland. dario.neri@pharma.ethz.ch.
authors.forename: Raphael M
authors.initials: RM
authors.lastname: Franzini
authors.forename: Angela
authors.initials: A
authors.lastname: Nauer
authors.forename: Jörg
authors.initials: J
authors.lastname: Scheuermann
authors.forename: Dario
authors.initials: D
authors.lastname: Neri
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D057166:High-Throughput Screening Assays; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D051381:Rats; D012709:Serum Albumin / Q000037:antagonists & inhibitors*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D012709:Serum Albumin; D054852:Small Molecule Libraries; D004247:DNA