title: Computerized methodology for micro-CT and histological data inflation using an IVUS based translation map.
abstract: A framework for the inflation of micro-CT and histology data using intravascular ultrasound (IVUS) images, is presented. The proposed methodology consists of three steps. In the first step the micro-CT/histological images are manually co-registered with IVUS by experts using fiducial points as landmarks. In the second step the lumen of both the micro-CT/histological images and IVUS images are automatically segmented. Finally, in the third step the micro-CT/histological images are inflated by applying a transformation method on each image. The transformation method is based on the IVUS and micro-CT/histological contour difference. In order to validate the proposed image inflation methodology, plaque areas in the inflated micro-CT and histological images are compared with the ones in the IVUS images. The proposed methodology for inflating micro-CT/histological images increases the sensitivity of plaque area matching between the inflated and the IVUS images (7% and 22% in histological and micro-CT images, respectively).
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece.
authors.forename: Lambros S
authors.initials: LS
authors.lastname: Athanasiou
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece.
authors.forename: George A
authors.initials: GA
authors.lastname: Rigas
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece.
authors.forename: Antonis I
authors.initials: AI
authors.lastname: Sakellarios
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece; FORTH-Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, GR 45110 Ioannina, Greece.
authors.forename: Themis P
authors.initials: TP
authors.lastname: Exarchos
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece.
authors.forename: Panagiotis K
authors.initials: PK
authors.lastname: Siogkas
authors.affiliation: Michaelidion Cardiac Center and Dept. of Cardiology, Medical School, University of Ioannina, GR 45110 Ioannina, Greece.
authors.forename: Katerina K
authors.initials: KK
authors.lastname: Naka
authors.affiliation: Institute of Clinical Physiology, National Research Council, Pisa, IT, 56124, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Panetta
authors.affiliation: Institute of Clinical Physiology, National Research Council, Pisa, IT, 56124, Italy.
authors.forename: Gualtiero
authors.initials: G
authors.lastname: Pelosi
authors.affiliation: Institute of Clinical Physiology, National Research Council, Pisa, IT, 56124, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Vozzi
authors.affiliation: Michaelidion Cardiac Center and Dept. of Cardiology, Medical School, University of Ioannina, GR 45110 Ioannina, Greece.
authors.forename: Lampros K
authors.initials: LK
authors.lastname: Michalis
authors.affiliation: Institute of Clinical Physiology, National Research Council, Pisa, IT, 56124, Italy.
authors.forename: Oberdan
authors.initials: O
authors.lastname: Parodi
authors.affiliation: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, PO Box 1186, GR 45110 Ioannina, Greece; FORTH-Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, GR 45110 Ioannina, Greece; Michaelidion Cardiac Center and Dept. of Cardiology, Medical School, University of Ioannina, GR 45110 Ioannina, Greece. Electronic address: fotiadis@cc.uoi.gr.
authors.forename: Dimitrios I
authors.initials: DI
authors.lastname: Fotiadis
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods*
keywords: Histology; Image registration; Intravascular ultrasound; Micro-CT; Plaque characterization