title: Analysis of apoptosis-related genes in patients with clinically isolated syndrome and their association with conversion to multiple sclerosis.
abstract: To analyse whether the expression of apoptotic transcripts is associated with the conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS). Eleven candidate transcripts belonging to the death receptor pathway, BCL-2, the inflammasome complex and NF-ΚB family were studied in the nonconverting and converting CIS patients during the four-year follow-up period. Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels. The predominant expression of proapoptotic genes in patients with CIS suggests an increased potential to undergo apoptosis with the goal of terminating immune responses and regulating immune system homeostasis.
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland. Electronic address: sanna.hagman@uta.fi.
authors.forename: Sanna
authors.initials: S
authors.lastname: Hagman
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Kolasa
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland.
authors.forename: Pabitra
authors.initials: P
authors.lastname: Basnyat
authors.affiliation: Science Centre, Pirkanmaa Hospital District and School of Health Sciences, University of Tampere, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Helminen
authors.affiliation: Department of Clinical Physiology, Tampere University Hospital and University of Tampere Medical School, Finland.
authors.forename: Mika
authors.initials: M
authors.lastname: Kähönen
authors.affiliation: Medical Imaging Centre, Department of Diagnostic Radiology, Tampere University Hospital, Tampere, Finland.
authors.forename: Prasun
authors.initials: P
authors.lastname: Dastidar
authors.affiliation: Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, Tampere, Finland.
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.affiliation: Neuroimmunology Unit, Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland; Department of Neurology, Tampere University Hospital, Tampere, Finland.
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000235:genetics*; D053468:CARD Signaling Adaptor Proteins; D020170:Caspase 1 / Q000235:genetics / Q000378:metabolism; D015331:Cohort Studies; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D003711:Demyelinating Diseases; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism / Q000473:pathology*; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D053218:Receptors, Death Domain / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*
chemical_list: D053468:CARD Signaling Adaptor Proteins; D016207:Cytokines; D003598:Cytoskeletal Proteins; D016328:NF-kappa B; C402202:PYCARD protein, human; D053218:Receptors, Death Domain; D053773:Transforming Growth Factor beta1; D019938:Cyclin D1; D020170:Caspase 1
keywords: Apoptosis; BCL-2; Biomarkers; Clinically isolated syndrome; Multiple sclerosis