title: Lack of genetic associations between PPAR-γ gene rs1801282 polymorphism and Alzheimer's disease in general population: a meta-analysis.
abstract: Published studies have evaluated the association between PPAR-γ rs1801282 polymorphism and Alzheimer's disease (AD) susceptibility. However, a definitive conclusion remains elusive. The aim of this study was to derive a more precise estimation of this association. We searched PubMed, Embase, Alzgene database, Chinese National Knowledge Infrastructure (CNKI), China Biological Medicine Database and Wanfang Databases for related studies. Twelve case-control studies with a total of 4874 cases and 5439 controls were finally identified to be eligible studies in this meta-analysis. The association was assessed by summarizing the odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Overall, there was no significant association between PPAR-γ rs1801282 polymorphism and Alzheimer's disease risk in all genetic models (the allele model G vs. C: OR=1.09, 95% CI 0.99-1.19, p=0.07; the homozygous model GG vs. CC: OR=1.04, 95% CI 0.75-1.44, p=0.80; heterozygote model GC vs. CC: OR=1.11, 95% CI 1,00-1.22, p=0.05; the dominant model GG+GC vs. CC: OR=1.10, 95% CI 1.00-1.22, p=0.05; the recessive model GG vs. GC+CC: OR=1.02, 95% CI 0.74-1.41, p=0.90). In subgroup analysis by ethnicity, no significant difference was found in both Asians and Caucasians. In summary, the present meta-analysis suggests that the PPAR-γ rs1801282 polymorphism may not be associated with genetic susceptibility of AD in general population.
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Yongfu
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Hanbin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Chuyan
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China. Electronic address: qindongyun061010@126.com.
authors.forename: Dongyun
authors.initials: D
authors.lastname: Qin
authors.affiliation: Department of Pharmacology, Guangdong Medical College, Dongguan, Guangdong 523808, China. Electronic address: zoefu2014@126.com.
authors.forename: Hui
authors.initials: H
authors.lastname: Fu
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012307:Risk Factors
chemical_list: D047495:PPAR gamma
keywords: Alzheimer's disease; Meta-analysis; PPAR-γ rs1801282; Polymorphism