title: The selective dopamine D₃ receptor antagonist SB-277011-A significantly decreases binge-like consumption of ethanol in C57BL/J6 mice.
abstract: The authors show that the dopamine D3 antagonist SB-277011-A consistently and persistently decrease binge-like EtOH consumption at 30 mg/kg and it decreases binge-like consumption on days 3, 7, 9, and 11-13 at 15 mg/kg. These findings suggest that the brain's D3 receptor may also be involved in not only ethanol reward but binge drinking as well.
authors.affiliation: Psychology Department, Furman University, Greenville, South Carolina, 29613.
authors.forename: Onarae V
authors.initials: OV
authors.lastname: Rice
authors.forename: Charles A
authors.initials: CA
authors.lastname: Schonhar
authors.forename: J
authors.initials: J
authors.lastname: Gaál
authors.forename: Eliot L
authors.initials: EL
authors.lastname: Gardner
authors.forename: Charles R
authors.initials: CR
authors.lastname: Ashby
mesh_terms: D000427:Alcohol Deterrents / Q000494:pharmacology*; D000818:Animals; D063425:Binge Drinking / Q000188:drug therapy* / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000008:administration & dosage; D018492:Dopamine Antagonists / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects; D060766:Drinking Water / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage; D008810:Mice, Inbred C57BL; D009570:Nitriles / Q000494:pharmacology*; D011897:Random Allocation; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D044005:Tetrahydroisoquinolines / Q000494:pharmacology*
chemical_list: D000427:Alcohol Deterrents; D002492:Central Nervous System Depressants; D018492:Dopamine Antagonists; D060766:Drinking Water; D009570:Nitriles; D050637:Receptors, Dopamine D3; C409982:SB 277011; D044005:Tetrahydroisoquinolines; D000431:Ethanol
keywords: D3 receptor; binge drinking; dopamine; ethanol