title: DEGRO guidelines for the radiotherapy of non-malignant disorders : part III: hyperproliferative disorders.
abstract: OBJECTIVE
  Radiation therapy (RT) is an established and effective treatment modality in the management of a large variety of hyperproliferative disorders and benign neoplasms. Objective of this article is to summarize the updated DEGRO consensus S2e guideline recommendations.
  
  
  METHODS
  This report comprises an overview of the relevant aspects of the updated guidelines with regard to treatment decision, dose prescription, and RT technique for a selected group of disorders including Morbus Dupuytren (MD)/Morbus Ledderhose (ML), keloids, Peyronie's disease (induratio penis plastica, IPP), desmoid tumors, pigmented villonodular synovitis (PVNS), symptomatic vertebral hemangiomas (sVH), and Gorham-Stout syndrome (GSS). On the basis of results in the literature, we attempted to classify the level of evidence (LoE) and the grade of recommendation (GR) according to the Oxford criteria.
  
  
  RESULTS
  There is comprehensive evidence in the literature that RT is a reasonable and effective treatment modality for the treatment of all the above-mentioned disorders. The LoE varies from 2c to 4, and GR varies from A to C.
  
  
  CONCLUSIONS
  The use of RT can be recommended for the interdisciplinary management of most of the reported disorders. It can be used in the primary treatment approach and as an effective adjunct to other treatment modalities or in some indications as a valuable alternative treatment option. We hope that the updated DEGRO S2e consensus guideline recommendations are a helpful tool for radiation oncologists in the clinical decision-making process.
authors.affiliation: Center for Radiotherapy, Hamburg, Germany.
authors.forename: M Heinrich
authors.initials: MH
authors.lastname: Seegenschmiedt
authors.forename: Oliver
authors.initials: O
authors.lastname: Micke
authors.forename: Marcus
authors.initials: M
authors.lastname: Niewald
authors.forename: Ralph
authors.initials: R
authors.lastname: Mücke
authors.forename: Hans Theodor
authors.initials: HT
authors.lastname: Eich
authors.forename: Jan
authors.initials: J
authors.lastname: Kriz
authors.forename: Reinhard
authors.initials: R
authors.lastname: Heyd
mesh_terms: D049109:Cell Proliferation / Q000528:radiation effects*; D003240:Connective Tissue Diseases / Q000532:radiotherapy*; D019317:Evidence-Based Medicine; D005350:Fibroma / Q000532:radiotherapy*; D005355:Fibrosis / Q000532:radiotherapy*; D005858:Germany; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D018787:Radiation Oncology; D011879:Radiotherapy Dosage; D012955:Societies, Medical