title: Bioactive triterpenoids from Atriplex lasiantha.
abstract: Chromatographic purification of the ethyl acetate soluble fraction from the methanolic extract of Atriplex lasiantha yielded a new triterpenoid, 7β,15α,16β-trihydroxyolean-12-ene-28,30-dioic acid-3-O-β-D-xylopyranoside (1), along with two known triterpenoids, rotundifolioside I (2) and corchorusin B (3). Structures of the compounds 1-3 were elucidated through sophisticated NMR studies and high resolution mass spectrometry. The three isolates (1-3) were evaluated for antibacterial, antioxidant, and antiurease activities. Compound 2 exhibited the best antibacterial activity against Escherichiacoli with IC50 value of 66.25 μg/ml, whereas, all the tested compounds exhibited antioxidant (IC50 values of 68.7-75.4 μg/ml) and antiurease (IC50 values of 25.5-49.3 μg/ml) activities, respectively.
authors.affiliation: a Department of Chemistry , Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur , Bahawalpur 63100 , Pakistan.
authors.forename: Basharat
authors.initials: B
authors.lastname: Ali
authors.forename: Rehana
authors.initials: R
authors.lastname: Tabassum
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Asma
authors.initials: A
authors.lastname: Yaqoob
authors.forename: Tasneem
authors.initials: T
authors.lastname: Khatoon
authors.forename: Rasool Bakhsh
authors.initials: RB
authors.lastname: Tareen
authors.forename: Abdul
authors.initials: A
authors.lastname: Jabbar
authors.forename: Faiz-ul-Hassan
authors.initials: FU
authors.lastname: Nasim
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
mesh_terms: D000465:Algorithms; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D027466:Atriplex / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010154:Pakistan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C000602496:7beta,15alpha,16beta-trihydroxyolean-12-ene-28,30-dioic acid-3-O-beta-D-xylopyranoside; D000975:Antioxidants; D006027:Glycosides; D014315:Triterpenes
keywords: Atriplex lasiantha; biological activities; charaterization; triterpenoid