title: Seroprevalence of hepatitis A,B, and C viruses in Turkish alcoholic cirrhotics and the impact of hepatitis B on clinical profile.
abstract: BACKGROUND
  The aims of this study were to detect the seroprevalence of hepatitis A, B, and C viruses in Turkish alcoholic cirrhotics, and to evaluate the impact of hepatitis B infection on clinical profile at first admittance.
  
  
  METHODS
  Serological markers for hepatitis A, B, and C viruses in 300 alcoholic cirrhotics diagnosed between January 1994 and December 2012 were retrospectively reviewed. Among them, 148 eligible patients were divided into group 1 (HBsAg positive, n = 43) and group 2 (HBsAg and anti-HBc negative, n = 105). Clinical characteristics at first admittance of groups 1 and 2 were compared.
  
  
  RESULTS
  The seroprevalence of anti-HAV total, HBsAg, and anti-HCV was found to be 91.5%, 16.3%, and 8.2%, respectively. The prevalence of hepatocellular carcinoma was higher in the HbsAg-positive group compared to HbsAg- and anti-HBc-negative group (16.3% vs. 2.9%, p = 0.007). Other clinical features were similar in the two groups.
  
  
  CONCLUSIONS
  Alcoholic cirrhotics have higher frequencies of HBsAg and anti-HCV than the general population. These patients should be investigated for coexistent HBV and HCV infections, and HBV vaccination should not be neglected. Alcoholic cirrhotic patients with concomitant HBV infection should be closely screened for hepatocellular carcinoma.
authors.affiliation: Ege University Medical School, Izmir, Turkey. drtekinfatih@gmail.com.
authors.forename: Fatih
authors.initials: F
authors.lastname: Tekin
authors.forename: Fulya
authors.initials: F
authors.lastname: Gunsar
authors.forename: Elvan Isik
authors.initials: EI
authors.lastname: Erdogan
authors.forename: Ruchan Yazan
authors.initials: RY
authors.lastname: Sertoz
authors.forename: Zeki
authors.initials: Z
authors.lastname: Karasu
authors.forename: Galip
authors.initials: G
authors.lastname: Ersoz
authors.forename: Omer
authors.initials: O
authors.lastname: Ozutemiz
authors.forename: Ulus
authors.initials: U
authors.lastname: Akarca
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D030041:Hepatitis A virus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006509:Hepatitis B / Q000473:pathology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D014421:Turkey
chemical_list: D006508:Hepatitis Antibodies