title: Estimating demand and unmet need for allogeneic hematopoietic cell transplantation in the United States using geographic information systems.
abstract: OBJECTIVE
  Allogeneic hematopoietic cell transplantation (HCT) is an increasingly used therapy for many patients with hematologic malignancies and other marrow failure or immune system disorders. The purpose of this study was to quantify and visualize both the demand and unmet need for HCT.
  
  
  METHODS
  HCT use for 2012 was described using the Center for International Blood and Marrow Transplant Research registry. Potential demand for HCT was calculated using 2012 SEER data and published literature for HCT-treatable conditions. Point locations of transplant centers were geocoded using geographic information system (GIS) software; Thiessen polygons were created to establish adult (age 20 to 74 years) and pediatric (age 0 to 19 years) market areas. Market-area population estimates were calculated using 2012 population estimates by age aggregated by census block.
  
  
  RESULTS
  US market areas for HCTs were identified separately for transplant centers treating adult (n = 62) and pediatric patients (n = 52). Overall HCT demand among adults was 16,096, with an unmet need for HCTs of 10,276 patients. For pediatric patients, the total demand was 4,561, with an unmet need of 3,213 potential recipients. Evaluation of adult and pediatric market areas indicated that the largest unmet needs tended to be in areas with large populations.
  
  
  CONCLUSIONS
  Market-area maps and statistics developed using GIS will help communicate the unmet need for HCT, inform policy, and assist transplant centers in planning for the anticipated growth in HCT use.
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Kelsey L
authors.initials: KL
authors.lastname: Besse
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Jaime M
authors.initials: JM
authors.lastname: Preussler
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Murphy
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: Denzen
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Lill
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Chell
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Senneka
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH.
authors.forename: Navneet S
authors.initials: NS
authors.lastname: Majhail
authors.affiliation: National Marrow Donor Program; Center for International Blood and Marrow Transplant Research, Minneapolis, MN; Cedars-Sinai Medical Center, Los Angeles, CA; and Cleveland Clinic, Cleveland, OH eric.williams@nmdp.org.
authors.forename: Eric P
authors.initials: EP
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D040362:Geographic Information Systems; D006297:Health Services Accessibility; D006301:Health Services Needs and Demand; D018380:Hematopoietic Stem Cell Transplantation / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D014481:United States; D055815:Young Adult