title: Perineural granulomas in cutaneous sarcoidosis may be associated with sarcoidosis small-fiber neuropathy.
abstract: Perineural granulomas in cutaneous sarcoidosis have been rarely reported and their clinical significance has yet to be evaluated. Recently, a 27-year-old male presented with multiple pink papules on the flank and lower back, accompanied by a painful, burning sensation. Biopsies revealed well-defined granulomas, consistent with sarcoidosis, in the dermis and involving small cutaneous nerves. We hypothesized that perineural granulomas may be an under-recognized feature of cutaneous sarcoidosis and may be responsible for sensory disturbances. We reviewed cases from 29 consecutive patients with cutaneous sarcoidosis. Perineural granulomas were identified in 18/29 (62%) patients and in 22/40 (55%) biopsies. Perineural granulomas were identified in 7/9 biopsies from the proximal upper extremity, 1/3 from the distal upper extremity, 7/12 from the head and the neck, including 4/4 from the nose, 5/9 from the back, 1/2 from the flank and 1/1 from the proximal lower extremity and 0/4 from the distal lower extremity. The anatomical distribution is similar to sarcoidosis small-fiber neuropathy (SSFN), in which sarcoidosis patients without evident skin lesions experience sensory disturbances of unknown etiology involving the face, the proximal extremities and the trunk. Our results indicate perineural granulomas in cutaneous sarcoidosis are more common than previously appreciated, primarily involve the head, the proximal upper extremities and the back, and may be responsible for neurological manifestations.
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Munday
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT, USA.|Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: McNiff
authors.affiliation: Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Kalman
authors.initials: K
authors.lastname: Watsky
authors.affiliation: Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: DiCapua
authors.affiliation: Department of Pathology, Yale School of Medicine, New Haven, CT, USA.|Department of Dermatology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Anjela
authors.initials: A
authors.lastname: Galan
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D008297:Male; D012507:Sarcoidosis / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
keywords: granuloma; perineural; sarcoid; sarcoidosis