title: Potential crosstalk between cofilin-1 and EGFR pathways in cisplatin resistance of non-small-cell lung cancer.
abstract: Current challenge in oncology is to establish the concept of personalized medicine in clinical practice. In this context, non-small-cell lung cancer (NSCLC) presents clinical, histological and molecular heterogeneity, being one of the most genomically diverse of all cancers. Recent advances added Epidermal Growth Factor Receptor (EGFR) as a predictive biomarker for patients with advanced NSCLC. In tumors with activating EGFR mutations, tyrosine kinase inhibitors (TKI) are indicated as first-line treatment, although restricted to a very small target population. In this context, cofilin-1 (a cytosolic protein involved with actin dynamics) has been widely studied as a biomarker of an aggressive phenotype in tumors, and overexpression of cofilin-1 is associated with cisplatin resistance and poor prognosis in NSCLC. Here, we gather information about the predictive potential of cofilin-1 and reviewed the crosstalk between cofilin-1/EGFR pathways. We aimed to highlight new perspectives of how these interactions might affect cisplatin resistance in NSCLC. We propose that cofilin-1 quantification in clinical samples in combination with presence/absence of EGFR mutation could be used to select patients that would benefit from TKI's treatment. This information is of paramount importance and could result in a possibility of guiding more effective treatments to NSCLC patients.
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Carolina Beatriz
authors.initials: CB
authors.lastname: Müller
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Marco Antônio
authors.initials: MA
authors.lastname: De Bastiani
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Matheus
authors.initials: M
authors.lastname: Becker
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Fernanda Stapenhorst
authors.initials: FS
authors.lastname: França
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Mariane Araujo
authors.initials: MA
authors.lastname: Branco
authors.affiliation: Programa de Pós-Graduação em Bioinformática, Federal University of Paraná (UFPR), Curitiba (PR), Brazil.
authors.forename: Mauro Antônio Alves
authors.initials: MA
authors.lastname: Castro
authors.affiliation: Laboratory of Cellular Biochemistry, Department of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre (RS), Brazil.|National Institutes for Science & Technology-Translational Medicine (INCT-TM), Porto Alegre (RS), Brazil.
authors.forename: Fabio
authors.initials: F
authors.lastname: Klamt
mesh_terms: D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D051338:Cofilin 1 / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction
chemical_list: D051338:Cofilin 1; D066246:ErbB Receptors; D002945:Cisplatin