title: Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization.
abstract: BACKGROUND
  This study was to evaluate the effectiveness of PRP in the therapy of infertile women with thin endometrium (≤ 7 mm).
  
  
  METHODS
  Five women undergoing in vitro fertilization (IVF) with poor endometrial response still had thin endometrium (< 7 mm) after standard hormone replacement therapy (HRT) and had to cancel embryo transfer cycle. In addition to HRT, intrauterine infusion of PRP was performed. PRP was prepared from autologous blood by centrifugation, and 0.5-1 ml of PRP was infused into the uterine cavity on the 10(th) day of HRT cycle. If endometrial thickness failed to increase 72 h later, PRP infusion was done 1-2 times in each cycle. Embryos were transferred when the endometrium thickness reached > 7 mm.
  
  
  RESULTS
  Successful endometrial expansion and pregnancy were observed in all the patients after PRP infusion. Intrauterine PRP infusion represent a new method for the thin endometrium with poor response.
  
  
  CONCLUSIONS
  This article reported that platelet-rich plasma (PRP) was able to promote the endometrial growth and improve pregnancy outcome of patients with thin endometrium.
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Yajie
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Jingjie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080, China.
authors.forename: Yuqing
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Wei
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Yang
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Center for Reproductive Medicine, Sixth Affiliated Hospital of Sun Yat-Sen University Guangzhou 510000, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liang
keywords: Thin endometrium; in vitro fertilization; platelet-rich plasma