title: A new cytotoxic benzophenanthridine isoquinoline alkaloid from the fruits of Macleaya cordata.
abstract: A new cytotoxic benzophenanthridine isoquinoline alkaloid, named cordatine (1), together with one known alkaloid 8-methoxydihydrochelerythrine (2), was isolated from the fruits of Macleaya cordata. The structure of the new compound was elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS. Both compounds indicated significant cytotoxicity against MCF-7 and SF-268 cell lines.
authors.affiliation: a Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy Jinan University , Guangzhou 510632 , China.
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Zou
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Li
authors.forename: Bai-Lian
authors.initials: BL
authors.lastname: Liu
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053119:Benzophenanthridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007546:Isoquinolines; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D028101:Papaveraceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D053119:Benzophenanthridines; D004365:Drugs, Chinese Herbal; D007546:Isoquinolines; C000602498:cordatine; C039109:isoquinoline
keywords: Macleaya cordata; benzophenanthridine alkaloid; cordatine