title: The interdependent roles of Ca(2+) and cAMP in axon guidance.
abstract: Axon guidance is a fundamental process in the developing and regenerating nervous system that is necessary for accurate neuronal wiring and proper brain function. Two of the most important second messengers in axon guidance are Ca(2+) and cAMP. Recently experimental and theoretical studies have uncovered a Ca(2+) - and cAMP-dependent mechanism for switching between attraction and repulsion. Here, we review this process and related Ca(2+) and cAMP interactions, the mechanisms by which necessary intracellular calcium elevations are created, and the pathways, which effect attractive and repulsive responses to the switch.
authors.affiliation: Queensland Brain Institute, The University of Queensland, St Lucia, QLD, 4072, Australia.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sutherland
authors.forename: Geoffrey J
authors.initials: GJ
authors.lastname: Goodhill
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D009474:Neurons / Q000166:cytology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000242:Cyclic AMP; D002118:Calcium
keywords: CaMKII; PKA; calcineurin; calcium; growth cone