title: Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 in fibromyalgia and interleukin-1 β in rheumatoid arthritis.
abstract: The purpose of this study was to relate central inflammation to autonomic activity (heart rate variability (HRV)) in patients with rheumatoid arthritis (RA) and fibromyalgia (FM). RA patients had reduced parasympathetic activity and FM patients had increased sympathetic activity compared to healthy controls. Comparisons between RA and FM showed higher cerebrospinal fluid (CSF) interleukin (IL)-1β inversely correlated to parasympathetic activity in RA. The FM patients had higher concentrations of CSF IL-8, IL-1Ra, IL-4 and IL-10, but none of these cytokines correlated with HRV. In conclusion, we found different profiles of central cytokines, i.e., elevated IL-1β in inflammatory pain (RA) and elevated IL-8 in dysfunctional pain (FM).
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Electronic address: eva.kosek@ki.se.
authors.forename: Eva
authors.initials: E
authors.lastname: Kosek
authors.affiliation: Department of Medicine, Unit of Rheumatology, CMM, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Reem
authors.initials: R
authors.lastname: Altawil
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: Diana
authors.initials: D
authors.lastname: Kadetoff
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Insitute, Stockholm, Sweden.
authors.forename: Anja
authors.initials: A
authors.lastname: Finn
authors.affiliation: Department of Medicine, Unit of Rheumatology, CMM, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Marie
authors.initials: M
authors.lastname: Westman
authors.affiliation: Department of Medicine, Unit of Rheumatology, CMM, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Erwan
authors.initials: E
authors.lastname: Le Maître
authors.affiliation: Department of Clinical Neuroscience, Neuroimmunology Unit, CMM, Karolinska Institute, Stockholm, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Andersson
authors.affiliation: Department of Medicine, Unit of Cardiology, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Jensen-Urstad
authors.affiliation: Department of Medicine, Unit of Rheumatology, CMM, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Jon
authors.initials: J
authors.lastname: Lampa
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D005356:Fibromyalgia / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood* / Q000134:cerebrospinal fluid*; D016209:Interleukin-8 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010147:Pain Measurement; D011863:Radioimmunoassay; D013129:Spinal Puncture; D018709:Statistics, Nonparametric
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D016209:Interleukin-8
keywords: Cerebrospinal fluid; Chemokines; Cytokines; Fibromyalgia; Glia cells; Heart rate variability; Rheumatoid arthritis