title: Implication of Candida parapsilosis FKS1 and FKS2 mutations in reduced echinocandin susceptibility.
abstract: We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel. All mutations detected were outside hot spot (HS) regions. The F1386S mutation detected in an isolate that was resistant by the YeastOne panel but not by the M27-A3 guidelines might be implicated in echinocandin resistance. Further studies are needed to confirm the implication of the F1386S mutation and to elucidate the capability of the M27-A3 guidelines to detect echinocandin resistance.
authors.affiliation: Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Martí-Carrizosa
authors.affiliation: Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain fsanchezr@santpau.cat.
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Reus
authors.affiliation: Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: March
authors.affiliation: Unidad de Microbiología Experimental, Centro de Investigación, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Cantón
authors.affiliation: Servei de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Coll
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000235:genetics; D025141:Drug Resistance, Fungal / Q000235:genetics; D054714:Echinocandins / Q000494:pharmacology*; D005656:Fungal Proteins / Q000235:genetics; D009154:Mutation
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D005656:Fungal Proteins