title: Effects of alpha lipoic acid on intra-abdominal adhesion: an experimental study in a rat model.
abstract: BACKGROUND
  This study was performed to determine the effect of alpha lipoic acid, a powerful antioxidant, on intra-abdominal adhesion formation.
  
  
  METHODS
  Twenty-four female Wistar Albino rats weighing 250-300 g were used in this study conducted on three groups consisting of the alpha lipoic acid group (Group I, n=8), control group (Group II, n=8), and sham group (Group III, n=8). After performing laparotomy with a midline incision under general anesthesia, the adhesion model was created on the antimesenteric side of the caecum in Group I and Group II. 50 mg/kg alpha-lipoic acid was administered intraperitoneally (IP) in Group I while the surgical procedure was performed but no drugs administered in Group II. Only laparotomy was performed in Group III. Rats were sacrificed at the end of the tenth day.
  
  
  RESULTS
  Macroscopic scoring was performed, tissue samples were obtained and subjected to biochemical and histopathological evaluation. The degree of adhesion and malondialdehyde level decreased (p<0.01), and glutathione levels had increased (p<0.01) in Group I compared to Group II in macroscopic scoring.
  
  
  CONCLUSIONS
  Alpha lipoic acid was found to significantly decrease (p<0.01) intra-abdominal adhesion when administered IP compared to the control group.
authors.affiliation: Department of General Surgery, Kafkas University Faculty of Medicine, Kars, Turkey. drtulaydiken@hotmail.com.
authors.forename: Tülay
authors.initials: T
authors.lastname: Diken Allahverdi
authors.affiliation: Department of Orthopedic and Traumatology, Kars State Hospital, Kars, Turkey.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Allahverdi
authors.affiliation: Department of Surgery, Kafkas University Faculty of Veterinary, Kars, Turkey.
authors.forename: Sadık
authors.initials: S
authors.lastname: Yayla
authors.affiliation: Department of Histology, Kafkas University Faculty of Veterinary, Kars, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Deprem
authors.affiliation: Department of Biochemistry, Kafkas University Faculty of Veterinary, Kars, Turkey.
authors.forename: Oguz
authors.initials: O
authors.lastname: Merhan
authors.affiliation: Department of Patology, Ankara University Faculty of Veterinary, Ankara, Turkey.
authors.forename: Sevil
authors.initials: S
authors.lastname: Vural
authors.affiliation: Department of General Surgery, Kafkas University Faculty of Medicine, Kars, Turkey.
authors.forename: Barlas
authors.initials: B
authors.lastname: Sülü
authors.affiliation: Department of Surgery, Kafkas University Faculty of Veterinary, Kars, Turkey.
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Günerhan
authors.affiliation: Department of General Surgery, Kafkas University Faculty of Medicine, Kars, Turkey.
authors.forename: Neşet
authors.initials: N
authors.lastname: Köksal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002432:Cecum / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005978:Glutathione / Q000378:metabolism; D007263:Infusions, Parenteral; D007813:Laparotomy; D008315:Malondialdehyde / Q000378:metabolism; D010532:Peritoneal Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000097:blood / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D008063:Thioctic Acid; D005978:Glutathione