title: Isolated heart models: cardiovascular system studies and technological advances.
abstract: Isolated heart model is a relevant tool for cardiovascular system studies. It represents a highly reproducible model for studying broad spectrum of biochemical, physiological, morphological, and pharmaceutical parameters, including analysis of intrinsic heart mechanics, metabolism, and coronary vascular response. Results obtained in this model are under no influence of other organ systems, plasma concentration of hormones or ions and influence of autonomic nervous system. The review describes various isolated heart models, the modes of heart perfusion, and advantages and limitations of various experimental setups. It reports the improvements of perfusion setup according to Langendorff introduced by the authors.
authors.affiliation: Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
authors.forename: Veronika
authors.initials: V
authors.lastname: Olejnickova
authors.forename: Marie
authors.initials: M
authors.lastname: Novakova
authors.forename: Ivo
authors.initials: I
authors.lastname: Provaznik
mesh_terms: D000818:Animals; D001001:Anura; D035843:Biomedical Research / Q000266:history / Q000379:methods; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D051379:Mice; D008955:Models, Cardiovascular; D010477:Perfusion; D051381:Rats