title: Selenium prevents lipid peroxidation in liver and lung tissues of rats in acute swimming exercise.
abstract: BACKGROUND
  Selenium, which is critical for human health, is necessary for various metabolic processes, including thyroid hormone metabolism, protection against oxidative stress, and immune function.
  
  
  OBJECTIVE
  The present study aims to examine how selenium administration affects lipid peroxidation in liver and lung tissues of rats subjected to acute swimming exercise.
  
  
  METHODS
  The study included 32 Spraque-Dawley adult male rats divided into Group 1 (general control), Group 2 (selenium-administered), Group 3 (swimming), and Group 4 (selenium-administered swimming). MDA and GSH levels were determined in liver and lung tissues.
  
  
  RESULTS
  The highest MDA values in the liver and lung tissues were found in group 3 in the study. MDA value in group 4 was higher than those in groups 1 and 2. Group 4 had the highest liver and lung GSH levels. GSH levels in Group 3 were higher than those in groups 1 and 2.
  
  
  CONCLUSIONS
  Results of the study indicate that acute swimming exercise causes lipid peroxidation in liver and lung tissues, while selenium administration prevents free radical formation by increasing antioxidant activity (Tab. 2, Ref. 26).
authors.forename: M
authors.initials: M
authors.lastname: Akil
authors.forename: U
authors.initials: U
authors.lastname: Gurbuz
authors.forename: M
authors.initials: M
authors.lastname: Bicer
authors.forename: I
authors.initials: I
authors.lastname: Halifeoglu
authors.forename: A K
authors.initials: AK
authors.lastname: Baltaci
authors.forename: R
authors.initials: R
authors.lastname: Mogulkoc
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000494:pharmacology*; D013550:Swimming / Q000502:physiology*
chemical_list: D008315:Malondialdehyde; D012643:Selenium
keywords: exercise; lipid peroxidation; rat.; selenium