title: Antidepressant use during pregnancy and asthma in the offspring.
abstract: OBJECTIVE
  It has been suggested that maternal depression during pregnancy is associated with asthma in the offspring, but the role of medical treatment of depression is not known. Our goal was to examine whether prenatal antidepressant use increases the risk of asthma in the offspring.
  
  
  METHODS
  A cohort study was performed among all live singletons born in Denmark between 1996 and 2007. Mothers who had a diagnosis of depressive disorder and/or who used antidepressants 1 year before or during the index pregnancy were identified. Using a Cox proportional hazards regression model, we estimated the hazard ratio (HR) for asthma in the offspring after antidepressant use during pregnancy.
  
  
  RESULTS
  Of the 733,685 children identified, 84,683 had a diagnosis of asthma. A total of 21,371 children were exposed to prenatal maternal depression (ie, a diagnosis of depressive disorder or use of antidepressants 1 year before or during pregnancy). Prenatal maternal depression was associated with childhood asthma (HR: 1.25 [95% confidence interval (CI): 1.20-1.30]). Overall, 8895 children were exposed to antidepressants in utero. Compared with children born to mothers with prenatal depression and no antidepressant use during pregnancy, the HR for asthma after any antidepressant use during pregnancy was 1.00 (95% CI: 0.93-1.08). HRs after use of selective serotonin reuptake inhibitors only, newer antidepressants only, and older antidepressants only were 0.95 (95% CI: 0.88-1.03), 1.11 (95% CI: 0.89-1.39), and 1.26 (95% CI: 1.02-1.55), respectively.
  
  
  CONCLUSIONS
  Antidepressant use during pregnancy generally did not increase the risk of asthma. Only use of older antidepressants was associated with an increased risk of asthma.
authors.affiliation: Section for Epidemiology, Department of Public Health, Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center for Research in Human Reproduction, National Population & Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China; and lxq@ph.au.dk.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Section for Epidemiology, Department of Public Health, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California.
authors.forename: Jørn
authors.initials: J
authors.lastname: Olsen
authors.affiliation: Department of Obstetrics and Gynecology, Institute of Clinical Medicine.
authors.forename: Lars Henning
authors.initials: LH
authors.lastname: Pedersen
authors.affiliation: National Centre for Register-Based Research, and CIRRAU-Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark;
authors.forename: Esben
authors.initials: E
authors.lastname: Agerbo
authors.affiliation: Department of Epidemiology and Social Science on Reproductive Health, Shanghai Institute of Planned Parenthood Research, WHO Collaborating Center for Research in Human Reproduction, National Population & Family Planning Key Laboratory of Contraceptive Drugs and Devices, Shanghai, China; and.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Section for Epidemiology, Department of Public Health.
authors.forename: Jiong
authors.initials: J
authors.lastname: Li
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003718:Denmark; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects; D016016:Proportional Hazards Models; D018570:Risk Assessment; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: antidepressant; asthma; childhood; cohort; pregnancy