title: Water-soluble Py-BIPS spiropyrans as photoswitches for biological applications.
abstract: The ultrafast photochemistry of a new spiropyran photoswitch (Py-BIPS) has been investigated, revealing many advantages in the application in water over the previously studied spiropyrans. Functionalized Py-BIPS derivatives are presented for the study of pH dependence, stability, toxicity, and the thermal and photochemical behavior on longer time scales in aqueous media using several spectroscopic methods. These investigations pave the way for the practical use of Py-BIPS derivatives as photoswitchable ligands of biomolecules.
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Cem
authors.initials: C
authors.lastname: Özçoban
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Halbritter
authors.affiliation: ‡Goethe-University Frankfurt, Institute for Physical and Theoretical Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt (M), Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Steinwand
authors.affiliation: ‡Goethe-University Frankfurt, Institute for Physical and Theoretical Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt (M), Germany.
authors.forename: Lisa-Marie
authors.initials: LM
authors.lastname: Herzig
authors.affiliation: ‡Goethe-University Frankfurt, Institute for Physical and Theoretical Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt (M), Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Kohl-Landgraf
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Noushin
authors.initials: N
authors.lastname: Askari
authors.affiliation: §Technical University of Darmstadt, Department of Biology, Schnittspahnstr. 10, 64287 Darmstadt, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Groher
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Fürtig
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Richter
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Schwalbe
authors.affiliation: §Technical University of Darmstadt, Department of Biology, Schnittspahnstr. 10, 64287 Darmstadt, Germany.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Suess
authors.affiliation: ‡Goethe-University Frankfurt, Institute for Physical and Theoretical Chemistry, Max-von-Laue-Str. 7, 60438 Frankfurt (M), Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Wachtveitl
authors.affiliation: †Goethe-University Frankfurt, Institute for Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 9, 60438 Frankfurt (M), Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Heckel
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D055668:Photochemical Processes; D014867:Water / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D007211:Indoles; D008024:Ligands; D009574:Nitro Compounds; C088184:spiropyran; D014867:Water