title: [Malignancies in adult patients with common variable immunodeficiency].
abstract: BACKGROUND
  Common variable immunodeficiency (CVID) implies an increased risk of cancer, with an estimated incidence of 11-13%, particularly during the 5th and 6th decade of life. B cell-Hodgkin lymphomas are the more frequent cancer, followed by non-Hodgkin lymphoma and epithelial tumors (gastric, breast, bladder and cervix).
  
  
  OBJECTIVE
  To describe the types of cancers in a cohort of adult patients with CVID.
  
  
  METHODS
  An observational, cross-sectional and descriptive study was made in which we reviewed the charts of patients with CVID attending the Primary Immunodeficiencies Clinic at Specialties Hospital Dr. Bernardo Sepulveda, Centro Medico Nacional Siglo XXI, Mexico City.
  
  
  RESULTS
  There were included 23 patients with CVID diagnosis, 13 women (56%) and 10 men (44%), with an average age of 36.7 years. Four patients developed malignancies (2 men and 2 women), with a prevalence of 17.3%. The types of cancers in this group of patients were: B cell-Hodgkin lymphoma (1/23), neuroendocrine carcinoma of the pancreas (1/23), myeloid chronic leukemia (1/23) and thyroid papillary carcinoma (1/23). In two of the subjects the diagnosis of cancer was established previous to CVID diagnosis. The average age of diagnosis of cancer was 27 years (19-34 years).
  
  
  CONCLUSIONS
  In our patients we found different types of malignancies compared to previously described. We consider necessary a screening protocol for an early diagnosis of cancer in these patients. The frequency of cancer in our population was the same as reported in the literature.
authors.affiliation: Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Distrito Federal, México. aeri_05@hotmail.com.
authors.forename: Eunice
authors.initials: E
authors.lastname: López-Rocha
authors.forename: Karen
authors.initials: K
authors.lastname: Rodríguez-Mireles
authors.forename: Nora Hilda
authors.initials: NH
authors.lastname: Segura-Méndez
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Yamazaki-Nakashimada
keywords: Cancer; Common variable immunodeficiency patients; Lymphoma; Neoplasm