title: Endothelial dysfunction and metabolic syndrome in preeclampsia: an alternative viewpoint.
abstract: Several clinical and basic science reports have elucidated partial aspects of the pathophysiology of preeclampsia and have led many authors to conclude that different "subtypes" of the disease exist. All these subtypes share the main clinical features of the disease and present additional characteristics that define different clinical phenotypes. Nevertheless, immunological alterations, endothelial dysfunction, and insulin resistance constantly characterize this syndrome. These aspects are intimately related at a molecular level; thus, we propose an alternative approach to explaining biologically the main intracellular processes that occur in preeclampsia and this may yield an insight into the pathogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria, Negrar, Verona, Italy. Electronic address: marcoscioscia@gmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Scioscia
authors.affiliation: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
authors.forename: S Ananth
authors.initials: SA
authors.lastname: Karumanchi
authors.affiliation: The Magda and Richard Hoffman Center for Human Placenta Research, Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
authors.forename: Debra
authors.initials: D
authors.lastname: Goldman-Wohl
authors.affiliation: Neonatology and NICU, La Réunion University Hospital, Saint Pierre, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Robillard
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*; D007333:Insulin Resistance; D020935:MAP Kinase Signaling System / Q000276:immunology; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism*; D010641:Phenotype; D011134:Polysaccharides / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000209:etiology / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*
chemical_list: D007295:Inositol Phosphates; D011134:Polysaccharides; C028039:inositol phosphate glycan
keywords: Angiogenic factor; Endothelial; Insulin resistance; Preeclampsia; Pregnancy; d-Chiro-inositol