title: Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress.
abstract: Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Susara Ruwan Kumara
authors.initials: SR
authors.lastname: Madduma Hewage
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Mei Jing
authors.initials: MJ
authors.lastname: Piao
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Ki Cheon
authors.initials: KC
authors.lastname: Kim
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Cha
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Xia
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-052, Republic of Korea.
authors.forename: Yung Hyun
authors.initials: YH
authors.lastname: Choi
authors.affiliation: Aging Research Center, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chae
authors.affiliation: Jeju National University School of Medicine, Jeju 690-756, Republic of Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Hyun
keywords: Apoptosis; Galangin; Human keratinocytes; Oxidative damage; Ultraviolet B