title: Association of rs712 polymorphism in Kras gene 3'-luntranslated region and cancer risk: a meta-analysis.
abstract: OBJECTIVE
  Mutation and polymorphism of Kras oncogene are considered as candidate risk factor and drug response predictor for cancer. However, the conclusions of accumulating reports related to the relationship of rs712 of Kras gene and risk of cancer remain nuclear.
  
  
  METHODS
  We performed a meta-analysis including 6 eligible studies containing 1661 cases and 2139 controls to explore the role of rs712 in the risk of cancer development.
  
  
  RESULTS
  Meta-analysis results showed that rs712 allele T (P(H)=0.08, odds ratio/OR=1.35, 95% confidence interval/ CI=1.17-1.55) and genotype TT (P(H)=0.174, OR=2.32, 95% CI=1.60-3.37), and allele T carrier genotype (GT/TT) (P(H)=0.14, OR=1.30, 95% CI=1.10-1.55) were strongly associated with cancer in Chinese population. No evidence of association was observed between rs712 and risk of cancer in overall population.
  
  
  CONCLUSIONS
  The findings suggested that allele T, genotype TT and allele T carrier (GT/TT) of rs712 may increase susceptibility to cancer risk in Chinese population, and can be used as a genetic factor for evaluating risk of cancer.
authors.affiliation: Department of Neurosurgery, Xianning Center Hospital, Xianning, Hubei Province, China.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Zhao
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Qu
authors.forename: Zhe-Gang
authors.initials: ZG
authors.lastname: Xing
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Zhao
authors.forename: Long
authors.initials: L
authors.lastname: Qin
authors.forename: Chao
authors.initials: C
authors.lastname: Lv
mesh_terms: D020413:3' Untranslated Regions; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras); D012307:Risk Factors; D018631:ras Proteins / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins