title: Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers.
abstract: A series of lipophilic nucleosides comprising natural and non-natural bases that are π-conjugated to a short oligophenylene-ethynylene fragment has been synthesized. These bases comprise guanosine, isoguanosine, and 2-aminoadenosine as purine heterocycles, and cytidine, isocytosine and uridine as complementary pyrimidine bases. The hydrogen-bonding dimerization and association processes between complementary bases were also studied by (1)H NMR and absorption spectroscopy in order to obtain the relevant association constants.
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049, Madrid, Spain. david.gonzalez.rodriguez@uam.es.
authors.forename: J
authors.initials: J
authors.lastname: Camacho-García
authors.forename: C
authors.initials: C
authors.lastname: Montoro-García
authors.forename: A M
authors.initials: AM
authors.lastname: López-Pérez
authors.forename: N
authors.initials: N
authors.lastname: Bilbao
authors.forename: S
authors.initials: S
authors.lastname: Romero-Pérez
authors.forename: D
authors.initials: D
authors.lastname: González-Rodríguez
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D003596:Cytosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D019281:Dimerization; D006151:Guanosine / Q000138:chemical synthesis / Q000737:chemistry; D006860:Hydrogen Bonding; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D014529:Uridine / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D009705:Nucleosides; D011108:Polymers; C473966:poly(phenylene ethynylene); C093270:isocytosine; D006151:Guanosine; C008184:isoguanosine; C033854:2-aminoadenosine; D003596:Cytosine; D000241:Adenosine; D014529:Uridine