title: Trajectories of distress, anxiety, and depression among women with breast cancer: Looking beyond the mean.
abstract: OBJECTIVE
  Little is known about the development of psychological wellbeing over time among women who have been treated for breast cancer. The aim of this study was to identify distinct patterns of distress, anxiety, and depression in such women.
  
  
  METHODS
  We invited 426 consecutive women with newly diagnosed primary breast cancer to participate in this study, and 323 (76%) provided information on distress ('distress thermometer') and on symptoms of anxiety and depression ('hospital anxiety and depression scale'). Semiparametric group-based mixture modeling was used to identify distinct trajectories of distress, anxiety, and depressive symptoms assessed the week before surgery and four and eight months later. Logistic regression analysis was used to evaluate the characteristics of women in the distinct groups.
  
  
  RESULTS
  Although no sub-group of women with chronic severe anxiety or depressive symptoms was found, we did identify a sub-group of 8% of the women who experienced continuously severe distress. Young age, having a partner, shorter education, and receiving chemotherapy but not radiotherapy might characterize women whose psychological symptoms remain strong eight months after diagnosis.
  
  
  CONCLUSIONS
  By looking beyond the mean, we found that 8% of the women experienced chronic severe distress; no sub-groups with chronic severe anxiety or depression were identified. Several socio-demographic and treatment factors characterized the women whose distress level remained severe eight months after diagnosis. The results suggest that support could be focused on relatively small groups of patients most in need.
authors.affiliation: Survivorship Unit, Danish Cancer Society Research Center , Copenhagen , Denmark.
authors.forename: Pernille Envold
authors.initials: PE
authors.lastname: Bidstrup
authors.forename: Jane
authors.initials: J
authors.lastname: Christensen
authors.forename: Birgitte Goldschmidt
authors.initials: BG
authors.lastname: Mertz
authors.forename: Nina
authors.initials: N
authors.lastname: Rottmann
authors.forename: Susanne Oksbjerg
authors.initials: SO
authors.lastname: Dalton
authors.forename: Christoffer
authors.initials: C
authors.lastname: Johansen
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001007:Anxiety / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000523:psychology* / Q000628:therapy; D003718:Denmark; D003863:Depression / Q000175:diagnosis*; D004522:Educational Status; D005260:Female; D006801:Humans; D017533:Marital Status; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D011878:Radiotherapy; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012044:Regression Analysis; D012944:Social Support; D013315:Stress, Psychological / Q000175:diagnosis* / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents