title: [Molecular alterations in melanoma and targeted therapies].
abstract: Melanoma is a skin cancer whose incidence is increasing steadily. The recent discovery of frequent and recurrent genetic alterations in cutaneous melanoma allowed a molecular classification of tumors into distinct subgroups, and paved the way for targeted therapy. Several signaling pathways are involved in the progression of this disease with oncogenic mutations affecting signaling pathways: MAPK, PI3K, cAMP and cyclin D1/CDK4. In each of these pathways, several potential therapeutic targets have been identified and specific inhibitors have already been developed and have shown clinical efficacy. The use of these inhibitors is often conditioned by tumors genotyping. In France, melanomas genotyping is supported by the platforms of the National Cancer Institute (INCA), which implemented a national program ensuring access to innovation for personalized medicine. The identification of new targets in melanoma supplies a very active dynamic development of innovative molecules contributing to changing the therapeutic landscape of this pathology.
authors.affiliation: AP-HP, Hôpital Saint-Louis, Laboratoire de pharmacologie-génétique, 1, avenue Claude-Vellefaux, 75010 Paris, France; Inserm, U976, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR-S-976, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address: samia.mourah@gmail.com.
authors.forename: Samia
authors.initials: S
authors.lastname: Mourah
authors.affiliation: Inserm, U976, 1, avenue Claude-Vellefaux, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, UMR-S-976, 1, avenue Claude-Vellefaux, 75010 Paris, France; Centre d'oncodermatologie, AP-HP, Hôpital Saint-Louis, Département de dermatologie, 1, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: Céleste
authors.initials: C
authors.lastname: Lebbé
mesh_terms: D005838:Genotype; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000235:genetics* / Q000556:secondary; D058990:Molecular Targeted Therapy / Q000379:methods*; D009154:Mutation; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins
keywords: BRAF; MAP Kinases; MAPKinases; genotyping; génotypage; melanoma; mélanome; targeted therapies; thérapie ciblée