title: HIF1α allows monocytes to take a breather during sepsis.
abstract: How the immune system is negatively affected by sepsis is not fully understood. In this issue of Immunity, Shalova et al. (2015) show that during human sepsis monocytes upregulate hypoxia-inducible factor-α (HIF1-α) activity and acquire an immunosuppressive phenotype while retaining anti-bacterial and wound-healing properties.
authors.affiliation: Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JJ, UK. Electronic address: d.gilroy@ucl.ac.uk.
authors.forename: Derek W
authors.initials: DW
authors.lastname: Gilroy
authors.affiliation: Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JJ, UK. Electronic address: s.yona@ucl.ac.uk.
authors.forename: Simon
authors.initials: S
authors.lastname: Yona
mesh_terms: D065150:Cellular Reprogramming / Q000276:immunology*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000276:immunology*; D016867:Immunocompromised Host; D053592:Interleukin-1 Receptor-Associated Kinases / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C507771:IRAK3 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases