title: Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor.
abstract: CD6, one of the first antigens to be identified on T cells, is a membrane glycoprotein that physically associates with the antigen receptor complex. Because of this, its main function seems to involve the modulation of TCR-mediated signaling pathways. However, growing evidence indicates that this ancient and conserved scavenger-like receptor may also play a role as pattern recognition receptor (PRR), similar to other members of the scavenger receptor cysteine rich superfamily (SRCR-SF). Here, we discuss the functional interactions of CD6 with microbe- and damage-associated signals and the potential use of soluble forms of CD6 in the therapeutic treatment of bacterial infections, in particular multi-drug resistant bacterial strains. Importantly, microbe recognition by CD6 may also have functional consequences on T cell activation and differentiation, which remain to be explored.
authors.forename: Adelaida
authors.initials: A
authors.lastname: Sarukhan
authors.forename: Mario
authors.initials: M
authors.lastname: Martinez-Florensa
authors.forename: Cristina
authors.initials: C
authors.lastname: Escoda-Ferran
authors.forename: Esther
authors.initials: E
authors.lastname: Carrasco
authors.forename: Esther
authors.initials: E
authors.lastname: Carreras
authors.affiliation: Centre Esther Koplowitz, Rosselló 149-153, 08036, Barcelona, Spain. flozano@clinic.ub.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria / Q000276:immunology; D001424:Bacterial Infections / Q000188:drug therapy; D002454:Cell Differentiation; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D051116:Receptors, Scavenger / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C062279:CD6 antigen; D011948:Receptors, Antigen, T-Cell; D051116:Receptors, Scavenger