title: Synthesis of novel tryptamine-based macrocycles using an Ugi 4-CR/microwave assisted click-cycloaddition reaction protocol.
abstract: A practical synthesis of novel tryptamine-based macrocycles using an Ugi 4-CR/click-cycloaddition sequential reaction protocol is described. The main features of the macrocyclic scaffolds are a peptoid moiety, a 1,3-substituted indole nucleus, and a triazole ring.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S.N., Ciudad Universitaria, Coyoacán, México, D.F. O4510, México. lmiranda@unam.mx.
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Chavez-Acevedo
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D057930:Click Chemistry / Q000379:methods; D003500:Cyclization; D061565:Cycloaddition Reaction / Q000379:methods; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D008958:Models, Molecular; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry; D014363:Tryptamines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D047028:Macrocyclic Compounds; D034444:Peptoids; D014230:Triazoles; D014363:Tryptamines; C030820:tryptamine; C030374:indole