title: 99mTc-ECD brain perfusion SPECT imaging for the assessment of brain perfusion in cerebral palsy (CP) patients with evaluation of the effect of hyperbaric oxygen therapy.
abstract: OBJECTIVE
  The present study was carried out to evaluate cerebral perfusion in different types of cerebral palsy (CP) patients. For those patients who underwent hyperbaric oxygen therapy, brain perfusion before and after the therapy was compared.
  
  
  METHODS
  A total of 11 CP patients were enrolled in this study, of which 4 patients underwent oxygen therapy. Before oxygen therapy and at the end of 40 sessions of oxygen treatment, 99mTc-ECD brain perfusion single photon emission computed tomography (SPECT) was performed , and the results were compared.
  
  
  RESULTS
  A total of 11 CP patients, 7 females and 4 males with an age range of 5-27 years participated in the study. In brain SPECT studies, all the patients showed perfusion impairments. The region most significantly involved was the frontal lobe (54.54%), followed by the temporal lobe (27.27%), the occipital lobe (18.18%), the visual cortex (18.18%), the basal ganglia (9.09%), the parietal lobe (9.09%), and the cerebellum (9.09%). Frontal-lobe hypoperfusion was seen in all types of cerebral palsy. Two out of 4 patients (2 males and 2 females) who underwent oxygen therapy revealed certain degree of brain perfusion improvement.
  
  
  CONCLUSIONS
  This study demonstrated decreased cerebral perfusion in different types of CP patients. The study also showed that hyperbaric oxygen therapy improved cerebral perfusion in a few CP patients. However, it could keep the physiological discussion open and strenghten a link with other areas of neurology in which this approach may have some value.
authors.affiliation: Department of Nuclear Medicine, Kasra Hospital Tehran, Iran.
authors.forename: Mina Taghizadeh
authors.initials: MT
authors.lastname: Asl
authors.affiliation: Department of Neurology, Bushehr Medical University Hospital, Bushehr University of Medical Sciences Bushehr, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Yousefi
authors.affiliation: Department of Neurology, Bushehr Medical University Hospital, Bushehr University of Medical Sciences Bushehr, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Nemati
authors.affiliation: The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences Bushehr, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
keywords: 99mTc-ECD brain perfusion SPECT; Cerebral palsy (CP); hyperbaric oxygen therapy