title: Ancestry informative markers for distinguishing between Thai populations based on genome-wide association datasets.
abstract: The main purpose of this work was to identify a set of AIMs that stratify the genetic structure and diversity of the Thai population from a high-throughput autosomal genome-wide association study. In this study, more than one million SNPs from the international HapMap database and the Thai depression genome-wide association study have been examined to identify ancestry informative markers (AIMs) that distinguish between Thai populations. An efficient strategy is proposed to identify and characterize such SNPs and to test high-resolution SNP data from international HapMap populations. The best AIMs are identified to stratify the population and to infer genetic ancestry structure. A total of 124 AIMs were clearly clustered geographically across the continent, whereas only 89 AIMs stratified the Thai population from East Asian populations. Finally, a set of 273 AIMs was able to distinguish northern from southern Thai subpopulations. These markers will be of particular value in identifying the ethnic origins in regions where matching by self-reports is unavailable or unreliable, which usually occurs in real forensic cases.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Electronic address: kornkiat.v@chula.ac.th.
authors.forename: Kornkiat
authors.initials: K
authors.lastname: Vongpaisarnsin
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Jennifer Beth
authors.initials: JB
authors.lastname: Listman
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven Campus, West Haven, CT, USA.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Malison
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven Campus, West Haven, CT, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA; Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Gelernter
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D053803:Forensic Genetics / Q000379:methods*; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D060005:Genotyping Techniques; D060148:HapMap Project; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D025341:Principal Component Analysis; D013785:Thailand
chemical_list: D005819:Genetic Markers
keywords: Ancestry informative markers; Forensic; Fst; Population; SNP; Thai