title: Hsp90 inhibitor can inhibit UV carcinogenesis.
abstract: Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced (i) hyperplastic response, (ii) Hsp90β-PKCɛ interaction, and (iii) pStat3 and pAkt expression in mouse skin.
authors.affiliation: Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA; Department of Dermatology, Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA. Electronic address: skatiyar@uab.edu.
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Katiyar
mesh_terms: D000818:Animals; D016227:Benzoquinones / Q000737:chemistry*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D047029:Lactams, Macrocyclic / Q000737:chemistry*; D008545:Melanoma / Q000378:metabolism*; D009381:Neoplasms, Radiation-Induced / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*; D000096142:Cutaneous Malignant Melanoma
chemical_list: D016227:Benzoquinones; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; C112765:tanespimycin