title: Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer.
abstract: Aurora-B is a major kinase responsible for appropriate mitotic progression. Elevated expression of Aurora-B has been frequently associated with several types of cancer, including breast cancer. However, it is not clear whether the alteration contributes to tumor responses to therapies and prognosis. In this study, we conducted immunohistochemistry using antibodies against Aurora-B, S1981p-ATM, Ki67, and p53 in paraffin-embedded tumor tissues from 312 invasive breast cancer patients. The correlation between disease-free-survival (DFS) and Aurora-B expression was analyzed using the Kaplan-Meier method and log-rank test. A Cox proportional hazards regression analysis was used to determine whether Aurora-B was an independent prognostic factor for breast cancer. We found that Aurora-B expression was correlated with the proliferation index (P < 0.001) and p53 expression (P = 0.014) in breast cancer tissues. Further we found that Aurora-B expression was associated with lymph node metastasis (P = 0.002) and histological grade (P = 0.001). Multivariate analyses indicated that elevated Aurora-B expression predicted a poor survival. In a subgroup of patients that received neoadjuvant chemotherapy, we found that elevated Aurora-B contributed to chemoresistance (P = 0.011). In conclusion, elevated Aurora-B expression in breast cancer patients contributes to chemoresistance and predicts poor prognosis.
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Yiqian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Southern Research Institute Birmingham, AL 35205.
authors.forename: Chunling
authors.initials: C
authors.lastname: Jiang
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Huilan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Lv
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Qian
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fu
authors.affiliation: Department of Oncology, Southern Research Institute Birmingham, AL 35205.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Breast Pathology and Lab, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and Hospital Tianjin 300060, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064107:Aurora Kinase B / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor; C576921:AURKB protein, human; D064107:Aurora Kinase B
keywords: Aurora-B; breast cancer; chemoresistance; prognosis