title: Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies.
abstract: BACKGROUND
  Studies and systematic reviews have reached inconsistent conclusions on the role of 5, 10-methylenetetrahydrofolate reductase (MTHFR) polymorphism C677T in acute lymphoblastic leukemia (ALL) risk.
  
  
  METHODS
  The present meta-analysis comprising of 51 case-control studies, including 7892 cases and 14 280 controls was performed to reevaluate the association between MTHFR C677T polymorphism and ALL risk.
  
  
  RESULTS
  Statistical differences were found in the dominant model (TT+CT vs. CC, odd ratio (OR)=0.89, 95% CI, 0.79-1.00, P=0.04) and the CT vs. CC (OR=0.89, 95% CI, 0.80-1.00, P=0.05), but not in the allele contrast model (T vs. C, OR=0.92, 95% CI, 0.84-1.01, P=0.08), additive model (TT vs. CC, OR=0.87, 95% CI, 0.73-1.05, P=0.15), or recessive model (TT vs. CT+CC, OR=0.94, 95% CI, 0.81-1.10, P=0.44) in overall populations. In the subgroup analyses stratified by age (children and adults) and ethnicity (Asian and Caucasian), no significant associations between MTHFR C677T polymorphism and ALL risk were observed.
  
  
  CONCLUSIONS
  The current study found no sufficient evidence of a protective role of MTHFR C677T polymorphism in ALL susceptibility.
authors.affiliation: Laboratory of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Su-yi
authors.initials: SY
authors.lastname: Li
authors.affiliation: Laboratory of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Jie-yu
authors.initials: JY
authors.lastname: Ye
authors.affiliation: Laboratory of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: En-yu
authors.initials: EY
authors.lastname: Liang
authors.affiliation: Laboratory of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Li-xia
authors.initials: LX
authors.lastname: Zhou
authors.affiliation: Laboratory of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors.forename: Mo
authors.initials: M
authors.lastname: Yang
mesh_terms: D000367:Age Factors; D016022:Case-Control Studies; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology* / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)