title: Serotonergic genes and depressive disorder in acute coronary syndrome: The Korean depression in ACS (K-DEPACS) study.
abstract: Genes coding for the serotonergic pathway have been associated with depressive disorders. However, these associations have rarely been tested in acute coronary syndrome (ACS) patients vulnerable to depression. This study aimed to investigate whether polymorphisms of serotonin transporter (5-HTT) and serotonin 2a receptor (5-HTR2a) genes are associated with occurrence of depressive disorder in ACS. 969 patients with recently developed ACS were recruited at baseline, and 711 were followed 1 year thereafter. Depressive disorder was diagnosed according to DSM-IV criteria, and analysed as an outcome at baseline (prevalence), and follow up (incidence and persistence). Genotypes were ascertained for 5-HTTLPR, STin2 VNTR, 5-HTR2a 102T/C, and 5-HTR2a 1438A/G. Logistic regression models were used to investigate associations. The 5-HTTLPR s/s genotype was independently associated with depressive disorder prevalence and persistence following ACS, but no significant associations were found with the other polymorphisms. ACS patients with the 5-HTTLPR s allele are thus potentially susceptible to depressive disorder in the early phase after ACS, and with its persistence over the subsequent year.
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea. Electronic address: jmkim@chonnam.ac.kr.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: King׳s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hee-Ju
authors.initials: HJ
authors.lastname: Kang
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Kyung-Yeol
authors.initials: KY
authors.lastname: Bae
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sung-Wan
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Shin
authors.affiliation: Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.affiliation: Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.affiliation: Department of Cardiology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Haeundae Paik Hospital, and Paik Institute for Clinical Research & FIRST research group, Inje University, Busan, Korea.
authors.forename: Sung-Woo
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Neuropsychiatry, School of Medicine, Haeundae Paik Hospital, and Paik Institute for Clinical Research & FIRST research group, Inje University, Busan, Korea.
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003863:Depression / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D056910:Republic of Korea; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D050486:Serotonin Plasma Membrane Transport Proteins
keywords: Acute coronary syndrome; Depression; Genetic association study; Serotonin receptor; Serotonin transporter