title: Growth profile and SEM analyses of Candida albicans and Escherichia coli with Hymenocallis littoralis (Jacq.) Salisb leaf extract.
abstract: Hymenocallis littoralis (Jacq.) Salisb (Melong kecil) commonly known as 'Spider Lily' is an herbaceous plant from the family Amaryllidaceae. Study was carried out to determine the effect of H. littoralis leaf extract on the growth and morphogenesis of two pathogenic microbes, Candida albicans and Escherichia coli. The leaf extract displayed favourable anticandidal and antibacterial activity with a minimum inhibition concentration (MIC) of 6.25 mg/mL. Time kill study showed both microbes were completely killed after treated with leaf extract at 20 h. Both microbes' cell walls were heavily ruptured based on scanning electron microscopy (SEM) analysis. The significant anticandidal and antibacterial activities showed by H. littoralis leaf extract suggested the potential antimicrobial agent against C. albicans and E. coli.
authors.affiliation: School of Biological Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
authors.forename: N
authors.initials: N
authors.lastname: Rosli
authors.affiliation: School of Distance Education, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
authors.forename: V
authors.initials: V
authors.lastname: Sumathy
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Vikneswaran
authors.affiliation: School of Biological Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Sreeramanan
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002473:Cell Wall / Q000187:drug effects / Q000648:ultrastructure; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D019668:Liliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D010936:Plant Extracts / Q000302:isolation & purification / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts