title: [Sarcoma of the hand and wrist].
abstract: Sarcomas of the hand and wrist are rare malignancies, which should be referred to high-volume comprehensive cancer centres providing multidisciplinary treatment options. The tumour board should propose patient-oriented oncological pathways as well as sophisticated hand and plastic reconstructive procedures. In Addition, isolated limb perfusion with TNF-alpha and melphalan is likely to lead to preoperative tumour shrinkage allowing for R0 resection in sano. Our clinical results in long-term survivors demonstrate reduced amputation rates and salvage of basic hand function when a risk-adapted treatment rationale is applied.
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Sektion Sarkomchirurgie, Westdeutsches Tumorzentrum CCC, Universitätsklinikum Essen, Universität Duisburg-Essen.
authors.forename: H U
authors.initials: HU
authors.lastname: Steinau
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Sektion Sarkomchirurgie, Westdeutsches Tumorzentrum CCC, Universitätsklinikum Essen, Universität Duisburg-Essen.
authors.forename: F
authors.initials: F
authors.lastname: Farzaliyev
authors.affiliation: Institut für Pathologie der Ruhr-Universität Bochum, UK-Bergmannsheil RUB, Bochum.
authors.forename: I
authors.initials: I
authors.lastname: Stricker
authors.affiliation: Plastische Chirurgie, Alfried Krupp Krankenhaus Steele, Essen.
authors.forename: J
authors.initials: J
authors.lastname: Hauser
authors.affiliation: Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Sektion Sarkomchirurgie, Westdeutsches Tumorzentrum CCC, Universitätsklinikum Essen, Universität Duisburg-Essen.
authors.forename: L E
authors.initials: LE
authors.lastname: Podleska
mesh_terms: D000293:Adolescent; D000328:Adult; D000671:Amputation, Surgical / Q000379:methods; D001859:Bone Neoplasms / Q000473:pathology / Q000628:therapy*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D005260:Female; D006225:Hand / Q000473:pathology / Q000601:surgery*; D006801:Humans; D033183:Interdisciplinary Communication; D023821:Limb Salvage / Q000379:methods; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D019651:Plastic Surgery Procedures / Q000379:methods*; D012509:Sarcoma / Q000473:pathology / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage; D014953:Wrist / Q000473:pathology / Q000601:surgery*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D008558:Melphalan