title: Efficacy and safety of jollab to treat functional dyspepsia: a randomized placebo-controlled clinical trial.
abstract: BACKGROUND
  Functional dyspepsia (FD) is a common gastrointestinal disease that is highly prevalent worldwide. Because of its heterogeneous pathophysiology, treatment options for FD can be difficult to choose; in this context, complementary and alternative medicine modalities have been suggested as promising options.
  
  
  OBJECTIVE
  To evaluate the efficacy of a traditional Persian medicine, jollab, in reducing patients' FD symptoms.
  
  
  METHODS
  In a double-blind randomized clinical trial, 160 patients with a diagnosis of FD were enrolled and treated with either jollab or placebo (15ml, t.i.d., four weeks, orally). The outcomes reported were changes in symptom frequency and severity as recorded in patients' diaries and evaluated with the Short Form of the Leeds Dyspepsia Questionnaire (SF-LDQ), and physical examination.
  
  
  RESULTS
  The response rate was higher in the treatment group (78%) than in the placebo group (31%) according to per-protocol sample analysis (P < .001). Symptoms of FD disappeared significantly more frequently, and the rate of concomitant synthetic drug consumption was significantly lower, in the jollab group compared to the placebo group at the end of the trial. Mean total symptom frequency and severity according to the SF-LDQ score was 1.55 ± 2.78 in the treatment group versus 5.61 ± 3.80 in the placebo group at the last follow-up time point (P < .001). A promising safety profile for jollab was observed throughout the trial.
  
  
  CONCLUSIONS
  In patients with FD, jollab appeared to be more effective than the placebo. Complementary and alternative therapies such as the use of this traditional medicinal substance may be beneficial in relieving symptoms of dyspepsia [ACTRN12613000584730].
authors.affiliation: School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Vali Asr Ave., Tehran, Iran. Electronic address: Pasalar@sums.ac.ir.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Pasalar
authors.affiliation: School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Vali Asr Ave., Tehran, Iran.
authors.forename: Rasool
authors.initials: R
authors.lastname: Choopani
authors.affiliation: Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Mosaddegh
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kamalinejad
authors.affiliation: Department of Traditional Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Abdolali
authors.initials: A
authors.lastname: Mohagheghzadeh
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Fattahi
authors.affiliation: Research Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Hafez Hospital, Shiraz, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Ghanizadeh
authors.affiliation: Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Kamran
authors.initials: K
authors.lastname: Bagheri Lankarani
mesh_terms: D000328:Adult; D027622:Crocus; D004311:Double-Blind Method; D004415:Dyspepsia / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007492:Iran; D008297:Male; D008519:Medicine, Traditional; D008875:Middle Aged; D010808:Physical Examination; D028321:Plant Preparations / Q000627:therapeutic use*; D011788:Quality of Life; D027824:Rosaceae; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D028321:Plant Preparations
keywords: Functional dyspepsia; efficacy; jollab; safety; traditional Persian medicine