title: Gender-specific associations of serum antibody to Porphyromonas gingivalis and inflammatory markers.
abstract: It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females.
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Furuta
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan ; Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shimazaki
authors.affiliation: Japanese Red Cross Kumamoto Healthcare Center, Kumamoto 861-8528, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Tanaka
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Takeuchi
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Shibata
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Takeshita
authors.affiliation: Section of Periodontology, Division of Oral Rehabilitation, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Fusanori
authors.initials: F
authors.lastname: Nishimura
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka 812-8582, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood* / Q000276:immunology; D016866:Bacteroidaceae Infections / Q000097:blood* / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000276:immunology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000097:blood / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D000907:Antibodies, Bacterial; D015415:Biomarkers; D002097:C-Reactive Protein