title: Nuclear factor of activated T cells in cancer development and treatment.
abstract: Since nuclear factor of activated T cells (NFAT) was first identified as a transcription factor in T cells, various NFAT isoforms have been discovered and investigated. Accumulating studies have suggested that NFATs are involved in many aspects of cancer, including carcinogenesis, cancer cell proliferation, metastasis, drug resistance and tumor microenvironment. Different NFAT isoforms have distinct functions in different cancers. The exact function of NFAT in cancer or the tumor microenvironment is context dependent. In this review, we summarize our current knowledge of NFAT regulation and function in cancer development and treatment. NFATs have emerged as a potential target for cancer prevention and therapy.
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Shou
authors.affiliation: Department of Medical Oncology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jing
authors.affiliation: Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Liangkun
authors.initials: L
authors.lastname: You
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Yao
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: hanwd@zju.edu.cn.
authors.forename: Weidong
authors.initials: W
authors.lastname: Han
authors.affiliation: Department of Medical Oncology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Laboratory of Cancer Biology, Institute of Clinical Science, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: Hongming
authors.initials: H
authors.lastname: Pan
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D006801:Humans; D050778:NFATC Transcription Factors / Q000378:metabolism*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D020033:Protein Isoforms; D013601:T-Lymphocytes / Q000378:metabolism; D059016:Tumor Microenvironment
chemical_list: D050778:NFATC Transcription Factors; D020033:Protein Isoforms
keywords: Calcineurin; Drug resistance; Metastasis; NFAT; Tumor microenvironment