title: The role of serum methylglyoxal on diabetic peripheral and cardiovascular autonomic neuropathy: the ADDITION Denmark study.
abstract: OBJECTIVE
  Cardiovascular autonomic neuropathy and diabetic peripheral neuropathy are common diabetic complications and independent predictors of cardiovascular disease. The glucose metabolite methylglyoxal has been suggested to play a causal role in the pathogeneses of diabetic peripheral neuropathy and possibly diabetic cardiovascular autonomic neuropathy. The aim of this study was to investigate the cross-sectional association between serum methylglyoxal and diabetic peripheral neuropathy and cardiovascular autonomic neuropathy in a subset of patients in the ADDITION-Denmark study with short-term screen-detected Type 2 diabetes (duration ~ 5.8 years).
  
  
  METHODS
  The patients were well controlled with regard to HbA(1c), lipids and blood pressure. Cardiovascular autonomic neuropathy was assessed by measures of resting heart rate variability and cardiovascular autonomic reflex tests. Diabetic peripheral neuropathy was assessed by vibration detection threshold (n = 319), 10 g monofilament (n = 543) and the Michigan Neuropathy Screening Instrument questionnaire (n = 966). Painful diabetic neuropathy was assessed using the Brief Pain Inventory short form (n = 882).
  
  
  RESULTS
  No associations between methylglyoxal and cardiovascular autonomic reflex tests or any measures of diabetic peripheral neuropathy or painful diabetic neuropathy were observed. However, a positive association between methylglyoxal and several heart rate variability indices was observed, although these associations were not statistically significant when corrected for multiple testing.
  
  
  CONCLUSIONS
  Serum methylglyoxal is not associated with cardiovascular autonomic neuropathy, diabetic peripheral neuropathy or painful diabetic neuropathy in this cohort of well-treated patients with short-term diabetes.
authors.affiliation: Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte, Denmark.
authors.forename: C S
authors.initials: CS
authors.lastname: Hansen
authors.affiliation: Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte, Denmark.
authors.forename: T M
authors.initials: TM
authors.lastname: Jensen
authors.affiliation: Department of Cardiology, Gentofte Hospital, Denmark.
authors.forename: J S
authors.initials: JS
authors.lastname: Jensen
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Nawroth
authors.affiliation: Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Fleming
authors.affiliation: Centre for Health Studies, CRP-Santé, Strassen, Luxembourg.
authors.forename: D R
authors.initials: DR
authors.lastname: Witte
authors.affiliation: Department of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Lauritzen
authors.affiliation: Department of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Sandbaek
authors.affiliation: Department of Public Health, Aarhus University, Aarhus, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Charles
authors.affiliation: Medical Research Laboratories, Clinical Institute of Medicine, Aarhus University, Aarhus, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Fleischer
authors.affiliation: Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte, Denmark.
authors.forename: D
authors.initials: D
authors.lastname: Vistisen
authors.affiliation: Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte, Denmark.
authors.forename: M E
authors.initials: ME
authors.lastname: Jørgensen
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003718:Denmark / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011765:Pyruvaldehyde / Q000097:blood*
chemical_list: D011765:Pyruvaldehyde