title: An epidemiological study to evaluate the use of vitamin K antagonists and new oral anticoagulants among non-valvular atrial fibrillation patients in Turkey- AFTER-2 study design.
abstract: OBJECTIVE
  Atrial fibrillation (AF) is one of the most common causes of preventable ischemic stroke and is related to increased cardiovascular morbidity and mortality. There is a lack of data in Turkey on the use of new oral anticoagulants (NOACs), and time in therapeutic INR range (TTR) in vitamin K antagonist users and AF management modality. In this multi-center trial, we aimed to analyze, follow and evaluate the epidemiological data in non-valvular AF patients.
  
  
  METHODS
  Four thousand one hundred consecutive adult patients from 42 centers with at least one AF attack identified on electrocardiography will be included in the study. Patients with rheumatic mitral valve stenosis and prosthetic valve disease will be excluded from the study. At the end of one year, the patients will be evaluated in terms of major cardiac end points (death, transient ischemic attack, stroke, systemic thromboembolism, major bleeding and hospitalization).
  
  
  RESULTS
  First results are expected in June 2015. Data about major cardiovascular end-points will be available in January 2016.
  
  
  CONCLUSIONS
  The rates and kind of oral anticoagulant use, TTR in vitamin K antagonist users and main management modality applied in non-valvular AF patients will be determined by AFTER-2 study. In addition, the rate of major adverse events (MACEs) and the independent predictors of these MACEs will be detected (AFTER-2 Study ClinicalTrials.gov number, NCT02354456.).
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ertaş
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Kaya
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yıldız
authors.affiliation: Department of Cardiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.
authors.forename: Vedat
authors.initials: V
authors.lastname: Davutoğlu
authors.affiliation: Department of Cardiology, Karadeniz Technique University Faculty of Medicine, Trabzon, Turkey.
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Kiriş
authors.affiliation: Department of Cardiology, Dışkapı Training and Research Hospital, Ankara, Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Dinç
authors.affiliation: Department of Cardiology, Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Habibe
authors.initials: H
authors.lastname: Kafes
authors.affiliation: Department of Cardiology, Koşuyolu Training and Research Hospital, İstanbul, Turkey.
authors.forename: Anıl
authors.initials: A
authors.lastname: Avcı
authors.affiliation: Department of Cardiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Bekir
authors.initials: B
authors.lastname: Calapkorur
authors.affiliation: Department of Cardiology, Siyami Ersek Training and Research Hospital, İstanbul, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ertaş
authors.affiliation: Department of Cardiology, Mehmet Akif Ersoy Training and Research Hospital, İstanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gül
authors.affiliation: Department of Cardiology, Bezmialem Foundation University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Nuray
authors.initials: N
authors.lastname: Kahraman Ay
authors.affiliation: Department of Cardiology, Medeniyet University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Bulur
authors.affiliation: Department of Cardiology, Mersin State Hospital, Mersin, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Durukan
authors.affiliation: Department of Cardiology, Bozyaka Training and Research Hospital, İzmir, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Eren
authors.affiliation: Department of Cardiology, Mardin State Hospital, Mardin, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: İlhan
authors.affiliation: Department of Cardiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
authors.forename: Murathan
authors.initials: M
authors.lastname: Küçük
authors.affiliation: Department of Cardiology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Özpelit
authors.affiliation: Department of Cardiology, Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.
authors.forename: Hakkı
authors.initials: H
authors.lastname: Şimşek
authors.affiliation: Department of Cardiology, Denizli State Hospital, Denizli, Turkey.
authors.forename: F Mehmet
authors.initials: FM
authors.lastname: Uçar
authors.affiliation: Department of Cardiology, Cardiology Institute, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Yıldız
authors.affiliation: Department of Cardiology, Numune Training and Research Hospital, Adana, Turkey.
authors.forename: D Yıldıray
authors.initials: DY
authors.lastname: Şahin
authors.affiliation: Department of Cardiology, Medical Park Hospital, Bursa, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Ayhan
authors.affiliation: Department of Cardiology, Çukurova University Faculty of Medicine, Adana, Turkey.
authors.forename: C Emre
authors.initials: CE
authors.lastname: Çağlayan
authors.affiliation: Department of Cardiology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Güngör
authors.affiliation: Department of Cardiology, Grand Medical Hospital, Manisa, Turkey.
authors.forename: Ferhat
authors.initials: F
authors.lastname: Özyurtlu
authors.affiliation: Department of Cardiology, Mustafa Kemal University Faculty of Medicine, Hatay, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Şen
authors.affiliation: Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Bülent
authors.initials: B
authors.lastname: Vatan
authors.affiliation: Department of Cardiology, Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
authors.forename: Fahriye
authors.initials: F
authors.lastname: Vatansever
authors.affiliation: Department of Cardiology, Fırat University Faculty of Medicine, Elazığ, Turkey.
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kobat
authors.affiliation: Department of Cardiology, Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.affiliation: Department of Cardiology, Trakya University Faculty of Medicine, Edirne, Turkey.
authors.forename: Gökay
authors.initials: G
authors.lastname: Taylan
authors.affiliation: Department of Cardiology, Abant İzzet Baysal University Faculty of Medicine, Bolu, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Dönmez
authors.affiliation: Department of Cardiology, Harran University Faculty of Medicine, Şanlıurfa, Turkey.
authors.forename: M Emre
authors.initials: ME
authors.lastname: Erkuş
authors.affiliation: Department of Cardiology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Söylemez
authors.affiliation: Department of Cardiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Zengin
authors.affiliation: Department of Cardiology, Fatih University Faculty of Medicine, İstanbul, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gündüz
authors.affiliation: Department of Cardiology, Selçuk University Faculty of Medicine, Konya, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuncez
authors.affiliation: Department of Cardiology, Hitit University Faculty of Medicine, Çorum, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Karavelioğlu
authors.affiliation: Department of Cardiology, Kafkas University Faculty of Medicine, Kars, Turkey.
authors.forename: Tayyar
authors.initials: T
authors.lastname: Gökdeniz
authors.affiliation: Department of Cardiology, Atatürk University Faculty of Medicine, Erzurum, Turkey.
authors.forename: Yavuzer
authors.initials: Y
authors.lastname: Koza
authors.affiliation: Department of Cardiology, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey.
authors.forename: Ziyaeddin
authors.initials: Z
authors.lastname: Aktop
authors.affiliation: Department of Cardiology, Mevlana University Faculty of Medicine, Konya, Turkey.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Katlandur
authors.affiliation: Department of Cardiology, Kastamonu State Hospital, Kastamonu, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Karaca Özer
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Yüksel
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Acet
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Habib
authors.initials: H
authors.lastname: Çil
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Alan
authors.affiliation: Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
authors.forename: Nizamettin
authors.initials: N
authors.lastname: Toprak
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000453:epidemiology*; D006801:Humans; D014421:Turkey / Q000453:epidemiology; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D000925:Anticoagulants; D014812:Vitamin K