title: Growth control: re-examining Zyxin's role in the hippo pathway.
abstract: The Hippo pathway is a conserved regulator of organ growth that computes information from the cellular microenvironment. A new study examines the role of the Hippo pathway protein Zyxin and finds that it antagonises Expanded to modulate F-actin and organ size.
authors.affiliation: Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria, Australia, 3002; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia, 3010; Department of Pathology, University of Melbourne, Parkville, Victoria, Australia, 3010. Electronic address: kieran.harvey@petermac.org.
authors.forename: Kieran F
authors.initials: KF
authors.lastname: Harvey
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D017344:Genes, Insect; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology; D009929:Organ Size / Q000235:genetics / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D000091102:YAP-Signaling Proteins; D060589:Zyxin / Q000235:genetics / Q000502:physiology*; D000099317:Hippo Kinases
chemical_list: D000199:Actins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D015534:Trans-Activators; D000091102:YAP-Signaling Proteins; D060589:Zyxin; C503814:Yki protein, Drosophila; C499520:Zyx protein, Drosophila; C085090:ex protein, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases