title: Steroidal sapogenins and glycosides from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera with anti-inflammatory activity.
abstract: Two new steroidal glycosides (1 and 2), together with 15 known compounds (3-17) were isolated from the fibrous roots of Ophiopogon japonicus, and three new steroidal glycosides (18-20), together with 14 known compounds (21-34) were isolated from the fibrous roots of Liriope spicata var. prolifera. The structures of the new compounds were elucidated on the basis of extensive one-dimensional (1D)- and 2D-NMR spectroscopic analyses and mass spectrometry. The isolated compounds were evaluated for their anti-inflammatory activity in vitro. Most of these steroidal glycosides showed significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol myristate acetate.
authors.affiliation: Department of Complex Prescription of TCM, China Pharmaceutical University.
authors.forename: Jin
authors.initials: J
authors.lastname: Qi
authors.forename: Zheng-fang
authors.initials: ZF
authors.lastname: Hu
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Yuan-jia
authors.initials: YJ
authors.lastname: Hu
authors.forename: Bo-yang
authors.initials: BY
authors.lastname: Yu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D031424:Liriope Plant; D009504:Neutrophils / Q000187:drug effects; D031441:Ophiopogon; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots; D012502:Sapogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010840:Phytosterols; D012502:Sapogenins