title: Guillain-Barré syndrome (demyelinating) six weeks after bariatric surgery: A case report and literature review.
abstract: Obesity is a major health problem worldwide. Bariatric surgery has been increasingly used to manage obesity. Many acute as well as chronic neurological complications have been reported after bariatric surgery including Guillain-Barré syndrome (GBS). An autoimmune process has been postulated as the underlying pathophysiology. Most of the reported cases of GBS after bariatric surgery are of the axonal variety. Here, we report a case of a demyelinating variety of GBS in a young woman who presented with acute onset of progressive weakness and paresthesia of all limbs within six weeks after bariatric surgery. She was treated with intravenous immunoglobulin (IVIG) and rehabilitation. She had complete recovery on follow-up. We believe that onset of acute inflammatory demyelinating polyradiculoneuropathy (AIDP), which is demyelinating variety of GBS, is associated with changes in immune system after bariatric surgery.
authors.affiliation: Neurology Section, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. Electronic address: noman.ishaque@aku.edu.
authors.forename: Noman
authors.initials: N
authors.lastname: Ishaque
authors.affiliation: Neurology Section, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. Electronic address: bhojo.Khealani@Aku.Edu.
authors.forename: Bhojo A
authors.initials: BA
authors.lastname: Khealani
authors.affiliation: General Surgery Section, Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan. Electronic address: amir.shariff@aku.edu.
authors.forename: Amir H
authors.initials: AH
authors.lastname: Shariff
authors.affiliation: Neurology Section, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan. Electronic address: mohammad.wasay@aku.edu.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Wasay
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000009:adverse effects*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D009767:Obesity, Morbid / Q000276:immunology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
keywords: Bariatric surgery; Demyelinating; GBS; Neuropathy; Obesity