title: A multi-center randomized trial of two different intravenous fluids during labor.
abstract: OBJECTIVE
  To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.
  
  
  METHODS
  This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation of <6 cm were randomized to lactated Ringer's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.
  
  
  RESULTS
  There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.
  
  
  CONCLUSIONS
  The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.
authors.affiliation: a Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA , USA .
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Dapuzzo-Argiriou
authors.affiliation: a Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA , USA .|b University of South Florida Morsani College of Medicine , Tampa , FL , USA .
authors.forename: John C
authors.initials: JC
authors.lastname: Smulian
authors.affiliation: a Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA , USA .
authors.forename: Meredith L
authors.initials: ML
authors.lastname: Rochon
authors.affiliation: c Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA , USA .
authors.forename: Luisa
authors.initials: L
authors.lastname: Galdi
authors.affiliation: c Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA , USA .
authors.forename: Jessika M
authors.initials: JM
authors.lastname: Kissling
authors.affiliation: c Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA , USA .
authors.forename: Peter F
authors.initials: PF
authors.lastname: Schnatz
authors.affiliation: d Department of Obstetrics and Gynecology , St. Luke's University Hospital , Bethlehem , PA , USA .
authors.forename: Angel
authors.initials: A
authors.lastname: Gonzalez Rios
authors.affiliation: d Department of Obstetrics and Gynecology , St. Luke's University Hospital , Bethlehem , PA , USA .
authors.forename: James
authors.initials: J
authors.lastname: Airoldi
authors.affiliation: e Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA , USA , and.
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Carrillo
authors.affiliation: e Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA , USA , and.
authors.forename: Jaimie
authors.initials: J
authors.lastname: Maines
authors.affiliation: f Department of Public Health Sciences , Pennsylvania State University College of Medicine , Hershey , PA , USA.
authors.forename: Allen R
authors.initials: AR
authors.lastname: Kunselman
authors.affiliation: e Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA , USA , and.
authors.forename: John
authors.initials: J
authors.lastname: Repke
authors.affiliation: e Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA , USA , and.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Legro
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data*; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007552:Isotonic Solutions; D007743:Labor, Obstetric; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D000077325:Ringer's Lactate; D055815:Young Adult
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D005947:Glucose
keywords: Cesarean delivery; IV fluids; dextrose; labor management