title: [Damage and functional recovery of the mouse retina after exposure to ionizing radiation and methylnitrosourea].
abstract: The eye retina consists of terminally differentiated cells that have lost their ability to proliferate. The death of these cells leads tothe loss of sight. The mice retina is characterized by relatively high resistance to radiation, which is provided by its ability to repair damage caused by environmental factors. The aim of our work was to assess the damaging effect of ionizing radiation and methylnitrosourea (MNU) on the DNA structure in the mouse retina, the functional activity of the retina, and its ability to recover in vivo. The results confirm the ability of the mature retina to structural and functional recovery. Adapting influence of low dose chemical agent increases retina resistance to cytotoxic dose of genotoxicants and prevents degeneration of photoreceptor layer of the retina. The results show the possibility of neurohormesis effect in the mice retina after exposure to ionizing radiation and chemicals.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Vinogradova
authors.forename: V A
authors.initials: VA
authors.lastname: Tronov
authors.forename: K N
authors.initials: KN
authors.lastname: Liakhova
authors.forename: V A
authors.initials: VA
authors.lastname: Poplinskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Ostrovskiĭ
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D004596:Electroretinography; D008770:Methylnitrosourea / Q000633:toxicity*; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010786:Photoreceptor Cells / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D011839:Radiation, Ionizing; D012160:Retina / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation
chemical_list: D008770:Methylnitrosourea