title: Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili).
abstract: Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral thrombotic events of the R. I. T. I. which occurred between January 2007 and June 2012. In the study period, 79 arterial ischaemic stroke (AIS) events (49 in males) and 91 cerebral sinovenous thrombosis (CSVT) events (65 in males) were enrolled in the R. I. T. I. Mean age at onset was 4.5 years in AIS, and 7.1 years in CSVT. Most common modes of presentation were hemiparesis, seizures and speech disturbances in AIS, and headache, seizures and lethargy in CSVT. Most common etiologies were underlying chronic diseases, vasculopathy and cardiopathy in AIS, and underlying chronic diseases and infection in CSVT. Time to diagnosis exceeded 24 hours in 46 % AIS and 59 % CSVT. Overall data from the Italian Registry are in substantial agreement with those from the literature, despite small differences. Among these, a longer time to diagnosis compared to other registries and case series poses the accent to the need of an earlier recognition of paediatric cerebrovascular events in Italy, in order to enable prompt and effective treatment strategies.
authors.forename: Agnese
authors.initials: A
authors.lastname: Suppiej
authors.forename: Chiara
authors.initials: C
authors.lastname: Gentilomo
authors.forename: Paola
authors.initials: P
authors.lastname: Saracco
authors.forename: Stefano
authors.initials: S
authors.lastname: Sartori
authors.forename: Manuela
authors.initials: M
authors.lastname: Agostini
authors.forename: Rossana
authors.initials: R
authors.lastname: Bagna
authors.forename: Bianca
authors.initials: B
authors.lastname: Bassi
authors.forename: Paola
authors.initials: P
authors.lastname: Giordano
authors.forename: Massimo
authors.initials: M
authors.lastname: Grassi
authors.forename: Andrea
authors.initials: A
authors.lastname: Guzzetta
authors.forename: Donatella
authors.initials: D
authors.lastname: Lasagni
authors.forename: Matteo
authors.initials: M
authors.lastname: Luciani
authors.forename: Angelo C
authors.initials: AC
authors.lastname: Molinari
authors.forename: Antonella
authors.initials: A
authors.lastname: Palmieri
authors.forename: Maria Caterina
authors.initials: MC
authors.lastname: Putti
authors.forename: Luca Antonelli
authors.initials: LA
authors.lastname: Ramenghi
authors.forename: Lidia Luciana
authors.initials: LL
authors.lastname: Rota
authors.forename: Domenico
authors.initials: D
authors.lastname: Sperlì
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Laverda
authors.affiliation: Prof. Paolo Simioni, Department of Medicine, University of Padua Medical School, Via Ospedale 105, 35100 Padua, Italy, Tel.: +39 04 9821 2667, Fax: +39 04 9821 2651, E-mail: paolo.simioni@unipd.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Simioni
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002545:Brain Ischemia / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D002539:Cerebral Arterial Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D057210:Delayed Diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D012008:Recurrence; D012042:Registries; D012307:Risk Factors; D012851:Sinus Thrombosis, Intracranial / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome
keywords: AIS; CSVT; Italy; Thrombosis; children; registry