title: Efficient synthesis of highly substituted tetrahydroindazolone derivatives.
abstract: A straightforward and efficient method for the synthesis of novel highly substituted and diversely functionalized indazolone derivatives has been developed. The transformation consists of a cyclocondensation of selected 1,3,3'-tricarbonyls with monosubstituted hydrazines. The starting β-triketones were prepared by an efficient chemo- and regioselective method under MW irradiation, exploiting the oxazolone chemistry. The reaction is easily accomplished under mild conditions and appears versatile, providing a synthetic diversification method with potential for drug-like compounds preparation.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Messina, V.le F. Stagno D'Alcontres 31, 98166, Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Scala
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Francesco
authors.initials: F
authors.lastname: Risitano
authors.forename: Santa
authors.initials: S
authors.lastname: Cirmi
authors.forename: Michele
authors.initials: M
authors.lastname: Navarra
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grassi
mesh_terms: D060326:Chemistry Techniques, Synthetic; D006834:Hydrazines / Q000737:chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D007191:Indazoles