title: Impact of low dose atorvastatin on development of new-onset diabetes mellitus in Asian population: Three-year clinical outcomes.
abstract: BACKGROUND
  High dose atorvastatin is known to be associated with new onset diabetes mellitus (NODM) in patients with high risk for developing diabetes mellitus (DM). However, low dose atorvastatin is more commonly used as compared with high dose atorvastatin. The aim of this study is to investigate the impact of low dose atorvastatin (LDA, 10mg or 20mg) on the development of NODM up to three years in Asian patients.
  
  
  METHODS
  From January 2004 to September 2009, we investigated a total of 3566 patients who did not have DM. To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. After PSM (C-statistics: 0.851), a total of 818 patients (LDA group, n=409 patients and control group, n=409 patients) were enrolled for analysis.
  
  
  RESULTS
  Before PSM, the cumulative incidence of NODM (5.8% vs. 2.1%, p<0.001), myocardial infarction (0.5% vs. 0.1%, p-value=0.007), and major adverse cardio-cerebral event (MACCE, 1.8% vs. 0.7%, p-value=0.012) at three-years were higher in the LAD group. However, after PSM, there was a trend toward higher incidence of NODM (5.9% vs. 3.2%, p=0.064) in the LDA group, but the incidence of MACCE (1.2% vs. 1.5%, p-value=1.000) was similar between the two groups. In multivariable analysis, the LDA administration was tended to be an independent predictor of NODM (OR: 1.99, 95% CI: 1.00-3.98, p-value 0.050).
  
  
  CONCLUSIONS
  In this study, the use of LDA tended to be a risk factor for NODM in Asian patients and reduced clinical events similar to the control group. However, large-scale randomized controlled trials will be needed to get the final conclusion.
authors.affiliation: Department of Cardiology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Park
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea. Electronic address: swrha617@yahoo.co.kr.
authors.forename: Seung-Woon
authors.initials: SW
authors.lastname: Rha
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: ByoungGeol
authors.initials: B
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea.
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Choi
authors.affiliation: Department of Cardiology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea.
authors.forename: Sung Kee
authors.initials: SK
authors.lastname: Ryu
authors.affiliation: Department of Cardiology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea.
authors.forename: Seunghwan
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Computer Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
authors.forename: Yung-Kyun
authors.initials: YK
authors.lastname: Noh
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Se Yeon
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Raghavender Goud
authors.initials: RG
authors.lastname: Akkala
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Hu
authors.initials: H
authors.lastname: Li
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Jabar
authors.initials: J
authors.lastname: Ali
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Xu
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Harris Abdullah
authors.initials: HA
authors.lastname: Ngow
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Jae Joong
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Gwang No
authors.initials: GN
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: JiBak
authors.initials: J
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Sunki
authors.initials: S
authors.lastname: Lee
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Jin Oh
authors.initials: JO
authors.lastname: Na
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Cheol Ung
authors.initials: CU
authors.lastname: Choi
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Hong Euy
authors.initials: HE
authors.lastname: Lim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Jin Won
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: EungJu
authors.initials: E
authors.lastname: Kim
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Chang Gyu
authors.initials: CG
authors.lastname: Park
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Hong
authors.initials: H
authors.lastname: SeogSeo
authors.affiliation: Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
authors.forename: Dong Joo
authors.initials: DJ
authors.lastname: Oh
mesh_terms: D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects; D044466:Asian People / Q000706:statistics & numerical data; D000069059:Atorvastatin / Q000008:administration & dosage / Q000009:adverse effects; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods; D050171:Dyslipidemias / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D000924:Anticholesteremic Agents; D001786:Blood Glucose; D000069059:Atorvastatin
keywords: Atorvastatin; New onset diabetes mellitus