title: Chordoid gliomas of the third ventricle share TTF-1 expression with organum vasculosum of the lamina terminalis.
abstract: Chordoid glioma of the third ventricle (CG3V) is a rare tumor developing in a stereotyped localization. It has been related to the circumventricular organ of the lamina terminalis, in the anterior part of the third ventricle, but its oncogenesis is poorly understood. TTF-1 transcription factor is involved in the development and adult physiology of the ventral forebrain. We studied the histopathologic and immunohistochemical features of a multicentric series of 17 cases of CG3V. We described additional histologic patterns (solid, fibrosing, and fusiform) to the typical chordoid pattern. TTF-1 was constantly expressed in CG3V, as in developing and adult lamina terminalis. The anti-TTF-1 SPT24 clone was more sensitive than the 8G7G3/1 clone. No mutation of IDH1 R132, IDH2 R172, or BRAF V600 codons was found. We showed TTF-1 as a useful marker for the diagnosis of CG3V and the understanding of its oncogenesis.
authors.affiliation: *Neuropathology Department Raymond-Escourolle ***AP-HP, Neurology 2 Mazarin Department, Pitié-Salpêtrière Hospital §§§Onconeurotek, Pitié-Salpêtrière Hospital ††Pathology Department, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris †Sorbonne Universités, UPMC Univ Paris 06, UM 75 ‡Institut National de la Santé et de la Recherche Médicale, U 1127 §Centre National de la Recherche Scientifique, UMR 7225, ICM ∥Brain and Spine Institute #Institut National de la Santé et de la Recherche Médicale, U1016, Institut Cochin, Université Paris Descartes, Paris ¶Department of Anatomical and Cytological Pathology, Hôpital Foch, Suresnes **Pathology Department, Hôpital Bretonneau, CHRU Tours, Tours ‡‡Pathology and Neuropathology Department, Centre de Biologie et Pathologie Est, Groupement Hospitalier Est, Hospices Civils de Lyon, Bron §§Pathology Department, Plateau technique de Biologie, CHU, Dijon ∥∥Department of Pathology, Caen University Hospital ¶¶Centre National de la Recherche Scientifique, UMR 6301 ISTCT CERVOxy Group, Caen ##Pathology Department, CHU Besançon, Besançon †††Pathology and Neuropathology Department, Assistance Publique-Hôpitaux de Marseille, AP-HM CHU, Timone ‡‡‡Aix-Marseille university, INSERM U911, Marseille, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Bielle
authors.forename: Chiara
authors.initials: C
authors.lastname: Villa
authors.forename: Marine
authors.initials: M
authors.lastname: Giry
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Bergemer-Fouquet
authors.forename: Marc
authors.initials: M
authors.lastname: Polivka
authors.forename: Alexandre
authors.initials: A
authors.lastname: Vasiljevic
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Aubriot-Lorton
authors.forename: Michèle
authors.initials: M
authors.lastname: Bernier
authors.forename: Emmanuèle
authors.initials: E
authors.lastname: Lechapt-Zalcman
authors.forename: Gabriel
authors.initials: G
authors.lastname: Viennet
authors.forename: Véronique
authors.initials: V
authors.lastname: Sazdovitch
authors.forename: Charles
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
mesh_terms: D000328:Adult; D000368:Aged; D002551:Cerebral Ventricle Neoplasms / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000096:biosynthesis*; D066278:Organum Vasculosum / Q000378:metabolism*; D012189:Retrospective Studies; D020542:Third Ventricle / Q000378:metabolism*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors