title: Reversible magnetic resonance imaging changes in a case of neuroleptic malignant syndrome.
abstract: Neuroleptic malignant syndrome (NMS) is a life-threatening neurologic emergency associated with the use of mainly typical antipsychotic drugs. It is characterized by fever, altered mental status, generalized rigidity, autonomic instability, myoclonus, raised creatine phosphokinase, rhabdomyolysis, and leukocytosis. Neuroimaging (brain computed tomography/magnetic resonance imaging [MRI]) is usually normal in most of the cases of NMS. Magnetic resonance imaging findings have not been well elucidated in NMS as yet. Very few cases have been reported worldwide. We herein, report a case of a 42-year-old patient of NMS, who presented to us with reversible changes in MRI brain. This case report highlights the possible MRI changes in NMS and their plausible mechanism.
authors.affiliation: Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.
authors.forename: Rajendra Singh
authors.initials: RS
authors.lastname: Jain
authors.affiliation: Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India. Electronic address: pankajniw04@gmail.com.
authors.forename: Pankaj Kumar
authors.initials: PK
authors.lastname: Gupta
authors.affiliation: Department of Psychiatry, SMS Medical College, Jaipur , Rajasthan, India.
authors.forename: Ishwar Dayal
authors.initials: ID
authors.lastname: Gupta
authors.affiliation: Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Agrawal
authors.affiliation: Department of Neurology, SMS Medical College, Jaipur, Rajasthan, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kumar
authors.affiliation: SMS Hospital, Jaipur, Rajasthan, India.
authors.forename: Shankar
authors.initials: S
authors.lastname: Tejwani
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology / Q000473:pathology*; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents