title: Characteristics of fibromyalgia independently predict poorer long-term analgesic outcomes following total knee and hip arthroplasty.
abstract: OBJECTIVE
  While psychosocial factors have been associated with poorer outcomes after knee and hip arthroplasty, we hypothesized that augmented pain perception, as occurs in conditions such as fibromyalgia, may account for decreased responsiveness to primary knee and hip arthroplasty.
  
  
  METHODS
  A prospective, observational cohort study was conducted. Preoperative phenotyping was conducted using validated questionnaires to assess pain, function, depression, anxiety, and catastrophizing. Participants also completed the 2011 fibromyalgia survey questionnaire, which addresses the widespread body pain and comorbid symptoms associated with characteristics of fibromyalgia.
  
  
  RESULTS
  Of the 665 participants, 464 were retained 6 months after surgery. Since individuals who met criteria for being classified as having fibromyalgia were expected to respond less favorably, all primary analyses excluded these individuals (6% of the cohort). In the multivariate linear regression model predicting change in knee/hip pain (primary outcome), a higher fibromyalgia survey score was independently predictive of less improvement in pain (estimate -0.25, SE 0.044; P < 0.00001). Lower baseline joint pain scores and knee (versus hip) arthroplasty were also predictive of less improvement (R(2) = 0.58). The same covariates were predictive in the multivariate logistic regression model for change in knee/hip pain, with a 17.8% increase in the odds of failure to meet the threshold of 50% improvement for every 1-point increase in fibromyalgia survey score (P = 0.00032). The fibromyalgia survey score was also independently predictive of change in overall pain and patient global impression of change.
  
  
  CONCLUSIONS
  Our findings indicate that the fibromyalgia survey score is a robust predictor of poorer arthroplasty outcomes, even among individuals whose score falls well below the threshold for the categorical diagnosis of fibromyalgia.
authors.affiliation: University of Michigan Health System, Ann Arbor.
authors.forename: Chad M
authors.initials: CM
authors.lastname: Brummett
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Urquhart
authors.forename: Afton L
authors.initials: AL
authors.lastname: Hassett
authors.forename: Alex
authors.initials: A
authors.lastname: Tsodikov
authors.forename: Brian R
authors.initials: BR
authors.lastname: Hallstrom
authors.forename: Nathan I
authors.initials: NI
authors.lastname: Wood
authors.forename: David A
authors.initials: DA
authors.lastname: Williams
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Clauw
mesh_terms: D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D001007:Anxiety / Q000523:psychology; D018771:Arthralgia / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D058443:Catastrophization / Q000523:psychology; D015331:Cohort Studies; D003863:Depression / Q000523:psychology; D005260:Female; D005356:Fibromyalgia / Q000150:complications / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000150:complications / Q000523:psychology / Q000601:surgery*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000523:psychology / Q000601:surgery*; D010146:Pain / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000700:Analgesics