title: Donepezil-related intractable hiccups: a case report.
abstract: This case report describes a man with intractable hiccups probably caused by donepezil. The patient's symptoms were not responsive to commonly used medications for hiccups, but they were improved and completely relieved upon donepezil dose deescalation and discontinuation. We report two occasions in which the discontinuation of donepezil resulted in hiccup resolution and three occasions in which initiation of donepezil was associated with the onset of hiccups. This report contributes to the growing body of literature that describes an association between centrally acting medications and intractable hiccups.
authors.affiliation: Department of Pharmacy, Providence St. Joseph Medical Center, Polson, Montana.
authors.forename: Ian R
authors.initials: IR
authors.lastname: McGrane
authors.forename: Michael D
authors.initials: MD
authors.lastname: Shuman
authors.forename: Robert W
authors.initials: RW
authors.lastname: McDonald
mesh_terms: D000368:Aged; D000077265:Donepezil; D017809:Fatal Outcome; D006606:Hiccup / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D007189:Indans / Q000009:adverse effects*; D008297:Male; D018697:Nootropic Agents / Q000009:adverse effects*; D010880:Piperidines / Q000009:adverse effects*
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D000077265:Donepezil
keywords: adverse drug event; cholinesterase inhibitors; donepezil; drug therapy; hiccough; hiccup; intractable hiccup; respiratory disease; singultus