title: Association of FPGS genetic polymorphisms with primary retroperitoneal liposarcoma.
abstract: Primary retroperitoneal liposarcoma is generally regarded as a genetic disorder. We have retrospectively genotyped 8 single nucleotide polymorphisms (SNPs) in 6 candidate genes (MDM2, CDK4, CDC27, FPGS, IGFN1, and PRAMEF13) in 138 patients and 131 healthy control subjects to evaluate the effects of genetic factors on individual susceptibility to primary retroperitoneal liposarcoma in Chinese population. Three SNPs (rs2870820, rs1695147, rs3730536) of MDM2 showed significant differences in single-loci genotypes and allele frequencies between case and control groups (p < 0.05). The minor allele G of SNP rs10760502 in FPGS (folylpolyglutamate synthase) gene was significantly associated with increased risk for primary retroperitoneal liposarcoma, compared with major allele A. Our data suggest that FPGS variant in Chinese population may affect individual susceptibility to primary retroperitoneal liposarcoma.
authors.affiliation: 1] Retroperitoneal Tumors Center, Peking University International Hospital, Beijing, P.R. China [2] Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Chengli
authors.initials: C
authors.lastname: Miao
authors.affiliation: Department of Neurology, The Third Hospital of Xiangya, Central South University, Changsha, Hunan, P.R. China.
authors.forename: Ding
authors.initials: D
authors.lastname: Liu
authors.affiliation: 1] National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, Jilin Province, P.R. China [2] Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.
authors.forename: Youxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Junhui
authors.initials: J
authors.lastname: Yu
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Zhanzhi
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, Beijing Shijitan Hospital, Capital Medical University (The 9th affiliated hospital of Peking University), Beijing, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Retroperitoneal Tumors Center, Peking University International Hospital, Beijing, P.R. China.
authors.forename: Chenghua
authors.initials: C
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000595:Amino Acid Sequence; D016022:Case-Control Studies; D019295:Computational Biology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D010453:Peptide Synthases / Q000737:chemistry / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017433:Protein Structure, Secondary; D012186:Retroperitoneal Neoplasms / Q000235:genetics* / Q000473:pathology; D012307:Risk Factors; D047368:Tumor Burden; D055815:Young Adult
chemical_list: D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase