title: Cannabinoid replacement therapy (CRT): Nabiximols (Sativex) as a novel treatment for cannabis withdrawal.
abstract: Cannabis is a common recreational drug that is generally considered to have low addictive potential. However, an increasing number of cannabis users are seeking treatment for dependence on the drug. There is interest in using agonist (substitution) pharmacotherapies to treat cannabis dependence and here we outline a novel approach involving a buccal spray (nabiximols) that contains tetrahydrocannabinol (THC) and cannabidiol (CBD). We review recent research with nabiximols and highlight findings relevant to clinical practice.
authors.affiliation: Psychopharmacology Laboratory, School of Psychology, Faculty of Science, University of Sydney, NSW, Australia.|Discipline of Addiction Medicine, Faculty of Medicine, University of Sydney, NSW, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Allsop
authors.affiliation: Discipline of Addiction Medicine, Faculty of Medicine, University of Sydney, NSW, Australia.|Drug and Alcohol Services, South East Sydney Local Health District, New South Wales Health, NSW, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Lintzeris
authors.affiliation: National Cannabis Prevention and Information Centre, UNSW Medicine, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Copeland
authors.affiliation: Drug & Alcohol Clinical Services, Hunter New England Local Health District, New South Wales Ministry of Health, Australia.|School of Medicine and Public Health, Faculty of Health, University of Newcastle, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Dunlop
authors.affiliation: Psychopharmacology Laboratory, School of Psychology, Faculty of Science, University of Sydney, NSW, Australia.
authors.forename: I S
authors.initials: IS
authors.lastname: McGregor
mesh_terms: D002185:Cannabidiol / Q000627:therapeutic use*; D013759:Dronabinol / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D002189:Marijuana Abuse / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D002185:Cannabidiol; D013759:Dronabinol; C587251:nabiximols