title: Comparison of changes over time in leukocyte counts in Yucatan minipigs irradiated with simulated solar particle event-like radiation.
abstract: During a major solar particle event (SPE), astronauts in space are at risk of exposure to an increased dose of proton radiation. The whole body distribution of the absorbed SPE proton dose is inhomogeneous, and such an inhomogeneous SPE proton dose can be simulated by electron radiation. Using Yucatan minipigs as an animal model, we compared the time courses of leukocyte count changes after exposure to proton simulated SPE (pSPE) radiation or electron simulated SPE (eSPE) radiation. The results demonstrated that the time required after irradiation to reach the lowest leukocyte counts was generally comparable between the pSPE and eSPE radiation exposures. However, the leukocyte count often recovered faster after electron irradiation compared to proton irradiation at the corresponding doses. In addition, the radiation dose required to achieve comparable magnitudes of leukocyte count decrease was higher in the eSPE animals than for the pSPE animals. In conclusion, based on the magnitude of the decrease and the time required to reach the lowest leukocyte counts after irradiation, the pSPE radiation was more effective than the eSPE radiation in reducing the peripheral leukocyte counts. Lymphocytes appeared to be the most sensitive type of leukocytes in response to either type of SPE radiation. It is particularly noteworthy that following exposure to pSPE radiation at the skin doses >5 Gy, the neutrophils do not recover from the radiation damage at times up to 30 days, and the neutrophils have not recovered to their baseline levels even at 90 days post-irradiation. These results suggest a marked difference in the ability of the neutrophils to recover from pSPE radiation compared with the results observed for eSPE radiation.
authors.forename: Jenine K
authors.initials: JK
authors.lastname: Sanzari
authors.forename: X Steven
authors.initials: XS
authors.lastname: Wan
authors.forename: Amy
authors.initials: A
authors.lastname: Muehlmatt
authors.forename: Liyong
authors.initials: L
authors.lastname: Lin
authors.forename: Ann R
authors.initials: AR
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004583:Electrons / Q000009:adverse effects*; D005118:Extraterrestrial Environment; D007958:Leukocyte Count; D007962:Leukocytes / Q000528:radiation effects*; D023421:Models, Animal; D009504:Neutrophils / Q000528:radiation effects*; D011522:Protons / Q000009:adverse effects*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D019445:Solar Activity; D013552:Swine; D013556:Swine, Miniature
chemical_list: D011522:Protons