title: Serum creatinine and alkaline phosphatase levels are associated with severe chronic periodontitis.
abstract: OBJECTIVE
  Periodontitis may alter systemic homeostasis and influence creatinine and alkaline phosphatase levels. Therefore, the aim of this study was to evaluate the relationship between severe chronic periodontitis and serum creatinine and alkaline phosphatase levels.
  
  
  METHODS
  One hundred patients were evaluated, 66 with severe chronic periodontitis (test group) and 34 periodontally healthy controls (control group). Medical, demographic and periodontal parameters were registered. Blood sample was collected after an overnight fast and serum creatinine and alkaline phosphatase levels were determined.
  
  
  RESULTS
  There were significant differences between test and control groups in ethnicity, gender and educational level (p < 0.05). Patients with periodontitis showed a lower mean creatinine level (p < 0.05) and higher mean alkaline phosphatase level (p < 0.001) than the control group. There were significant correlations between periodontal parameters and serum creatinine and alkaline phosphatase levels.
  
  
  CONCLUSIONS
  Severe chronic periodontitis was associated to lower creatinine and higher alkaline phosphatase levels.
authors.affiliation: Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: A L
authors.initials: AL
authors.lastname: Caúla
authors.affiliation: Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Lira-Junior
authors.affiliation: Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: E M B
authors.initials: EM
authors.lastname: Tinoco
authors.affiliation: Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
authors.forename: R G
authors.initials: RG
authors.lastname: Fischer
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D055113:Chronic Periodontitis / Q000473:pathology*; D003404:Creatinine / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry*; D055815:Young Adult
chemical_list: D003404:Creatinine; D000469:Alkaline Phosphatase
keywords: alkaline phosphatase; creatinine; periodontal disease; periodontitis