title: Association of peripheral total and differential leukocyte counts with obesity-related complications in young adults.
abstract: OBJECTIVE
  Obesity has been demonstrated to be associated with elevated leukocytes in adults and children. This study assessed the associations between peripheral total and differential leukocyte counts and obesity-related complications in young adults.
  
  
  METHODS
  12 obese (median age 21.5 (range 19-28) years, median BMI 35.7 (range 32.0-44.9) kg/m(2)) and 11 normal (median age 23 (range 18-27) years, median BMI 19.5 (range 18.1-21.7) kg/m(2)) adults were enrolled. Complete blood count and serum levels of liver enzymes, fasting blood glucose, insulin and lipids were measured, and the homeostasis model assessment of insulin resistance was calculated. Fat mass was calculated using a bioimpedance analysis device, and ultrasonography was performed to measure fat thickness and to detect fatty change of the liver.
  
  
  RESULTS
  Total leukocyte and monocyte counts were significantly increased in obese young adults. Total leukocyte count was associated with liver enzyme levels, insulin resistance as well as visceral and subcutaneous fat thickness. Neutrophil count was associated with insulin resistance. Lymphocyte count was associated with serum liver enzymes, insulin resistance, and dyslipidemia. Monocyte count was associated with serum liver enzyme, insulin resistance, visceral and subcutaneous fat thickness, body fat mass, and percentage body fat.
  
  
  CONCLUSIONS
  The results of this study suggest that chronic low-grade systemic inflammation is associated with obesity-related complications such as nonalcoholic fatty liver disease, insulin resistance, and dyslipidemia in young adults.
authors.affiliation: Health Care Center, Hokkaido University, Sapporo, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohnishi
authors.forename: Chieko
authors.initials: C
authors.lastname: Orito
authors.forename: Yukako
authors.initials: Y
authors.lastname: Kawahara
authors.forename: Hiroyo
authors.initials: H
authors.lastname: Takasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takeda
authors.forename: Naoya
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D050171:Dyslipidemias / Q000209:etiology* / Q000276:immunology; D005234:Fatty Liver / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000276:immunology*; D050152:Intra-Abdominal Fat / Q000378:metabolism; D007958:Leukocyte Count; D007962:Leukocytes / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D050151:Subcutaneous Fat / Q000378:metabolism; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids