title: A novel sensory nerve conduction study technique to evaluate the sural nerve from the forefoot to the knee.
abstract: OBJECTIVE
  Length-dependent polyneuropathy is common. Current electrophysiological methods cannot assess sensory nerve function proximal to the distal calf, limiting their utility in the quantification of severity of length-dependent polyneuropathy.
  
  
  METHODS
  The authors developed a novel electrophysiological approach for distal to proximal assessment of the sural nerve between the forefoot and the knee and tested it on 63 healthy young, middle-aged, and old adults.
  
  
  RESULTS
  It was feasible to elicit sensory nerve action potentials in the forefoot, ankle, and knee segments of the sural nerve in all subjects. Intraobserver (r = 0.87) and interobserver (r = 0.87) reliability were high. Sensory nerve action potential amplitudes were greatest at the ankle, followed by the knee and forefoot. Sensory nerve action potential amplitudes in the forefoot and ankle were significantly smaller in the old age group (>60 years) compared with the young age group (20-39 years) (P < 0.05). In contrast, neither age nor gender had a significant impact on sensory nerve action potential conduction velocities.
  
  
  CONCLUSIONS
  The authors demonstrated that reliable electrophysiological recordings of the sural nerve as proximal as the knee are feasible. This novel technique may be useful in patients with length-dependent polyneuropathy to monitor progression and to evaluate treatment response.
authors.affiliation: *Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada; and †Division of Physical Medicine & Rehabilitation, Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Zuo
authors.forename: Robyn
authors.initials: R
authors.lastname: Lee
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Clarke
authors.forename: Anson
authors.initials: A
authors.lastname: Dong
authors.forename: K Ming
authors.initials: KM
authors.lastname: Chan
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D004594:Electrophysiology / Q000379:methods*; D005260:Female; D005528:Foot; D006801:Humans; D007717:Knee; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D009460:Neurologic Examination / Q000379:methods*; D011115:Polyneuropathies / Q000175:diagnosis*; D015203:Reproducibility of Results; D013497:Sural Nerve / Q000502:physiology*; D055815:Young Adult