title: Enzymatic activities linked to cardiac energy metabolism of Trypanosoma evansi-infected rats and their possible functional correlations to disease pathogenesis.
abstract: The aim of this study was to investigate the activities of important enzymes involved in the phosphoryl transfer network (adenylate kinase and creatine kinase (CK)), lactate dehydrogenase (LDH), respiratory chain complexes and biomarkers of cardiac function in rat experimentally infected by Trypanosoma evansi. Rat heart samples were evaluated at 5 and 15 days post-infection (PI). At 5 day PI, there was an increase in LDH and CK activities, and a decrease in respiratory chain complexes II, IV and succinate dehydrogenase activities. In addition, on day 15 PI, a decrease in the respiratory chain complex IV activity was observed. Biomarkers of cardiac function were higher in infected animals on days 5 and 15 PI. Considering the importance of the energy metabolism for heart function, it is possible that the changes in the enzymatic activities involved in the cardiac phosphotransfer network and the decrease in respiratory chain might be involved partially in the role of biomarkers of cardiac function of T. evansi-infected rats.
authors.affiliation: Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
authors.forename: Matheus D
authors.initials: MD
authors.lastname: Baldissera
authors.affiliation: Laboratory of Nanotechnology,Centro Universitário Franciscano,Santa Maria,RS,Brazil.
authors.forename: Virginia C
authors.initials: VC
authors.lastname: Rech
authors.affiliation: Department of Biochemistry,Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,RS,Brazil.
authors.forename: Mateus
authors.initials: M
authors.lastname: Grings
authors.affiliation: Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
authors.forename: Lucas T
authors.initials: LT
authors.lastname: Gressler
authors.affiliation: Laboratory of Microbiology,Centro Universitário Franciscano,Santa Maria,RS,Brazil.
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Vaucher
authors.affiliation: Section of Veterinary Pathology,Instituto Federal Catarinense,Concórdia,SC,Brazil.
authors.forename: Claiton I
authors.initials: CI
authors.lastname: Schwertz
authors.affiliation: Section of Veterinary Pathology,Instituto Federal Catarinense,Concórdia,SC,Brazil.
authors.forename: Ricardo E
authors.initials: RE
authors.lastname: Mendes
authors.affiliation: Department of Biochemistry,Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,RS,Brazil.
authors.forename: Guilhian
authors.initials: G
authors.lastname: Leipnitz
authors.affiliation: Department of Animal Science,Universidade do Estado de Santa Catarina (UDESC),Chapecó,SC,Brazil.
authors.forename: Lenita M
authors.initials: LM
authors.lastname: Stefani
authors.affiliation: Department of Microbiology and Parasitology,Universidade Federal de Santa Maria (UFSM),Santa Maria,RS,Brazil.
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Monteiro
authors.affiliation: Department of Animal Science,Universidade do Estado de Santa Catarina (UDESC),Chapecó,SC,Brazil.
authors.forename: Aleksandro S
authors.initials: AS
authors.lastname: da Silva
mesh_terms: D000818:Animals; D015415:Biomarkers; D004579:Electron Transport / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D014345:Trypanosoma / Q000145:classification*; D014352:Trypanosomiasis / Q000378:metabolism / Q000469:parasitology*
chemical_list: D015415:Biomarkers
keywords: Phosphotransfer network; cardiac muscle; respiratory chain activities; ‘surra’