title: Metabolic connectivity as index of verbal working memory.
abstract: Positron emission tomography (PET) data are commonly analyzed in terms of regional intensity, while covariant information is not taken into account. Here, we searched for network correlates of healthy cognitive function in resting state PET data. PET with [(18)F]-fluorodeoxyglucose and a test of verbal working memory (WM) were administered to 35 young healthy adults. Metabolic connectivity was modeled at a group level using sparse inverse covariance estimation. Among 13 WM-relevant Brodmann areas (BAs), 6 appeared to be robustly connected. Connectivity within this network was significantly stronger in subjects with above-median WM performance. In respect to regional intensity, i.e., metabolism, no difference between groups was found. The results encourage examination of covariant patterns in FDG-PET data from non-neurodegenerative populations.
authors.affiliation: Department of Industrial Engineering, Arizona State University, Tempe, Arizona, USA.
authors.forename: Na
authors.initials: N
authors.lastname: Zou
authors.affiliation: Inserm-EPHE-Université de Caen, Caen, France.
authors.forename: Gael
authors.initials: G
authors.lastname: Chetelat
authors.affiliation: Department of Industrial Engineering, Bogazici University, Istanbul, Turkey.
authors.forename: Mustafa G
authors.initials: MG
authors.lastname: Baydogan
authors.affiliation: Department of Industrial Engineering, Arizona State University, Tempe, Arizona, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
authors.forename: Florian U
authors.initials: FU
authors.lastname: Fischer
authors.affiliation: Department of Nuclear Medicine, Technische Universität München, Munich, Germany.
authors.forename: Dmitry
authors.initials: D
authors.lastname: Titov
authors.affiliation: 1] Service of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland [2] Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Juergen
authors.initials: J
authors.lastname: Dukart
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Fellgiebel
authors.affiliation: Department of Nuclear Medicine, University Medical Center Mainz, Mainz, Germany.
authors.forename: Mathias
authors.initials: M
authors.lastname: Schreckenberger
authors.affiliation: 1] Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany [2] Department of Nuclear Medicine, Technische Universität München, Munich, Germany [3] Neuroimaging Center (TUM-NIC), Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Igor
authors.initials: I
authors.lastname: Yakushev
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000032:analysis; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008953:Models, Anatomic; D009415:Nerve Net / Q000033:anatomy & histology* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18