title: To be or not to be: The host genetic factor and beyond in Helicobacter pylori mediated gastro-duodenal diseases.
abstract: Helicobacter pylori (H. pylori) have long been associated with a spectrum of disease outcomes in the gastro-duodenal system. Heterogeneity in bacterial virulence factors or strains is not enough to explain the divergent disease phenotypes manifested by the infection. This review focuses on host genetic factors that are involved during infection and eventually are thought to influence the disease phenotype. We have summarized the different host genes that have been investigated for association studies in H. pylori mediated duodenal ulcer or gastric cancer. We discuss that as the bacteria co-evolved with the host; these host gene also show much variation across different ethnic population. We illustrate the allelic distribution of interleukin-1B, across different population which is one of the most popular candidate gene studied with respect to H. pylori infections. Further, we highlight that several polymorphisms in the pathway gene can by itself or collectively affect the acid secretion pathway axis (gastrin: somatostatin) thereby resulting in a spectrum of disease phenotype.
authors.affiliation: Dipanjana Datta De, R and D Division (Genetics), School of Human Genetics and Population Health, Kolkata 700012, India.
authors.forename: Dipanjana
authors.initials: D
authors.lastname: Datta De
authors.affiliation: Dipanjana Datta De, R and D Division (Genetics), School of Human Genetics and Population Health, Kolkata 700012, India.
authors.forename: Susanta
authors.initials: S
authors.lastname: Roychoudhury
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004381:Duodenal Ulcer / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology; D005755:Gastrins / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000150:complications / Q000235:genetics* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics; D018716:Molecular Mimicry; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D015398:Signal Transduction; D013004:Somatostatin / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology*; D014774:Virulence
chemical_list: D005755:Gastrins; C508585:IL1B protein, human; D053583:Interleukin-1beta; D013004:Somatostatin
keywords: Acid secretion; Cytokine; Duodenal ulcer; Gastric cancer; Helicobacter pylori