title: In vitro activities of hexaazatrinaphthylenes against Leishmania spp.
abstract: The in vitro activity of a novel group of compounds, hexaazatrinaphthylene derivatives, against two species of Leishmania is described in this study. These compounds showed a significant dose-dependent inhibition effect on the proliferation of the parasites, with 50% inhibitory concentrations (IC(50)s) ranging from 1.23 to 25.05 μM against the promastigote stage and 0.5 to 0.7 μM against intracellular amastigotes. Also, a cytotoxicity assay was carried out to in order to evaluate the possible toxic effects of these compounds. Moreover, different assays were performed to determine the type of cell death induced after incubation with these compounds. The obtained results highlight the potential use of hexaazatrinaphthylene derivatives against Leishmania species, and further studies should be undertaken to establish them as novel leishmanicidal therapeutic agents.
authors.affiliation: University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain atlopez@ull.edu.es.
authors.forename: Atteneri
authors.initials: A
authors.lastname: López-Arencibia
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Tenerife, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: García-Velázquez
authors.affiliation: University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Martín-Navarro
authors.affiliation: Laboratoire Matériaux-Molécules et Applications, IPEST, University of Carthage, La Marsa, Tunisia.
authors.forename: Ines
authors.initials: I
authors.lastname: Sifaoui
authors.affiliation: University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Reyes-Batlle
authors.affiliation: University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: Jacob
authors.initials: J
authors.lastname: Lorenzo-Morales
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Tenerife, Spain.
authors.forename: Ángel
authors.initials: Á
authors.lastname: Gutiérrez-Ravelo
authors.affiliation: University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: José E
authors.initials: JE
authors.lastname: Piñero
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D009281:Naphthalenes / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests
chemical_list: D000981:Antiprotozoal Agents; D009281:Naphthalenes; C547330:hexaazatrinaphthylene