title: Cutaneous epithelioid hemangioendothelioma on the sole of a child.
abstract: Epithelioid hemangioendothelioma (EHE) has been considered to be a low-grade malignant vascular neoplasm, although follow-up of recent series has demonstrated that EHE involving the skin and soft tissues should be better regarded as a fully malignant vascular tumor since it has more metastatic potential than previously thought. We report a case of an EHE involving the left sole of 6-year-old boy, the youngest patient with cutaneous EHE described to date. Immunohistochemical studies demonstrated a lymphatic endothelial line of differentiation for neoplastic cells. Cutaneous EHE is rare in childhood, with only five previously described cases.
authors.affiliation: Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Carranza-Romero
authors.affiliation: Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Molina-Ruiz
authors.affiliation: Department of Pathology, Hospital Universitario de Guadalajara, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: Cristian
authors.initials: C
authors.lastname: Perna Monroy
authors.affiliation: Department of Pathology, Hospital Universitario de Guadalajara, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Cuevas Santos
authors.affiliation: Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma de Madrid, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
mesh_terms: D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005528:Foot; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male