title: Overview of high-risk HPV's 16 and 18 infected cervical cancer: pathogenesis to prevention.
abstract: As general, the Human papillomavirus (HPV) causes the most sexually transmitted diseases. Among well categorized 80 types, the high-risk types HPV's 16 and 18 are highly involved in 70% of cervical cancer. The virulence of HPV is mainly exhibited by E5, E6 and E7 encoded oncoproteins that cause low to high-grade cervical lesions (CIN-1, 2, 3), leading to form 99.7% of squamous cell and 89% of adenocarcinomas cervical cancer worldwide. This study mainly encircles the major role of E5, E6 and E7 oncoproteins in HPV 16 and 18. Further discussed the uprising of significant biomarkers and their cellular process in different stages of cervical cancer with current prevention and treatment regimens. Hence, this integration will evoke novel markers, potential vaccination and various treatments approaches with special reference for HPV16 and 18 infected cervical cancers.
authors.affiliation: Bharathidasan University, Tiruchirappalli 620024, Tamilnadu, India.
authors.forename: Sabitha
authors.initials: S
authors.lastname: Ramakrishnan
authors.affiliation: Bharathidasan University, Tiruchirappalli 620024, Tamilnadu, India.
authors.forename: Steena
authors.initials: S
authors.lastname: Partricia
authors.affiliation: Bharathidasan University, Tiruchirappalli 620024, Tamilnadu, India. Electronic address: mathan@bdu.ac.in.
authors.forename: Ganeshan
authors.initials: G
authors.lastname: Mathan
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D005260:Female; D052162:Human papillomavirus 16 / Q000472:pathogenicity*; D052161:Human papillomavirus 18 / Q000472:pathogenicity*; D006801:Humans; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000821:virology*
chemical_list: D000998:Antiviral Agents
keywords: Biomarkers; Cervical cancer; HPV 16; HPV 18; Oncoproteins; Treatments; Vaccinations