title: Brain-derived neurotrophic factor and substrate utilization following acute aerobic exercise in obese individuals.
abstract: Brain-derived neurotrophic factor (BDNF) serves as a vital regulator of neuronal proliferation and survival, and has been shown to regulate energy homeostasis, glucose metabolism and body weight maintenance. Elevated concentrations of plasma BDNF have been associated with obesity and type 2 diabetes mellitus. Acute aerobic exercise transiently increases circulating BDNF, potentially correcting obesity-related metabolic impairment. The present study aimed to compare acute aerobic exercise elicited BDNF responses in obese and normal-weight subjects. Furthermore, we aimed to investigate whether acute exercise-induced plasma BDNF elevations would be associated with improved indices of insulin resistance, as well as substrate utilization [carbohydrate oxidation (CHOoxi) and fat oxidation (FAToxi)]. Twenty-two healthy, untrained subjects [11 obese (four men and seven women; age = 22.91 ± 4.44 years; body mass index = 35.72 ± 4.17 kg/m(2)) and 11 normal-weight (five men and six women; age = 23.27 ± 2.24 years; body mass index = 21.89 ± 1.63 kg/m(2))] performed 30 min of continuous submaximal aerobic exercise at 75% maximal oxygen consumption. Our analyses showed that the BDNF response to acute aerobic exercise was similar in obese and normal-weight subjects across time (time: P = 0.015; group: P = not significant) and was not associated with indices of IR. Although no differences in the rates of CHOoxi and FAToxi were found between both groups, total relative energy expenditure was significantly lower in obese subjects compared to normal-weight subjects (3.53 ± 0.25 versus 5.59 ± 0.85; P < 0.001). These findings suggest that acute exercise-elicited BDNF elevation may not be sufficient to modulate indices of IR or the utilization of either carbohydrates or fats in obese individuals.
authors.affiliation: Department of Exercise Science and Health Promotion, Florida Atlantic University, Boca Raton, FL, USA; Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Slusher
authors.forename: M
authors.initials: M
authors.lastname: Whitehurst
authors.forename: R F
authors.initials: RF
authors.lastname: Zoeller
authors.forename: J T
authors.initials: JT
authors.lastname: Mock
authors.forename: A
authors.initials: A
authors.lastname: Maharaj
authors.forename: C-J
authors.initials: CJ
authors.lastname: Huang
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D016022:Case-Control Studies; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005223:Fats / Q000378:metabolism; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D005223:Fats; C579455:BDNF protein, human
keywords: BDNF; carbohydrate oxidation; cardiorespiratory fitness; energy metabolism; fat oxidation; insulin resistance