title: The role of tumor suppressor gene SOX11 in prostate cancer.
abstract: SOX genes play an important role in a number of developmental processes. The transcription factor SOX11 is one of the members of the SOX family emerging as important transcriptional regulators. The aim of this study was to investigate the role of SOX11 in prostate cancer (PCa) and its expression pattern and clinical significance. The gene expression of SOX11 in human PCa tissues compared with benign prostate hyperplasia (BPH) tissues was detected using real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) analysis and immunohositochemistry. SOX11 overexpression cell model was used to examine the role of SOX11 in cell growth and metastasis in vitro. The results showed that the positive rate of SOX11 staining was 16.67 % (10/60) in cases of prostatic carcinoma and 81.67 % (49/60) in cases of BPH, and the difference of SOX11 expression between PCa and BPH was statistically significant (P < 0.001). SOX11 mRNA level was lowly expressed in PCa cell lines compared to RWPE-1. SOX11 overexpression suppresses PCa cell migration and invasion. In conclusion, our findings demonstrate that SOX11 could suppress cell proliferation, migration, and invasion of PCa in vitro.
authors.affiliation: Department of Urology, Air Force General Hospital of PLA, No.30 Fu Cheng Road, Beijing, 100142, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yao
authors.forename: Bin
authors.initials: B
authors.lastname: Sun
authors.forename: Quan
authors.initials: Q
authors.lastname: Hong
authors.forename: Jingmin
authors.initials: J
authors.lastname: Yan
authors.forename: Dawei
authors.initials: D
authors.lastname: Mu
authors.forename: Jianye
authors.initials: J
authors.lastname: Li
authors.forename: Haibo
authors.initials: H
authors.lastname: Sheng
authors.forename: Heqing
authors.initials: H
authors.lastname: Guo
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D012333:RNA, Messenger / Q000096:biosynthesis; D055751:SOXC Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D012333:RNA, Messenger; C097473:SOX11 protein, human; D055751:SOXC Transcription Factors