title: Palmitoleic acid calcium salt: a lubricant and bactericidal powder from natural lipids.
abstract: Palmitoleic acid is a promising bactericidal agent for cleansing products with alternative bactericidal abilities. In this study, we focus on the physical and biological activity of palmitoleic acid calcium salt (C16:1 fatty acid Ca salt) because it forms via an ion-exchange reaction between palmitoleic acid and Ca ions in tap water, and remains on the skin surface during the cleansing process. Here, we prepared C16:1 fatty acid Ca salt to investigate its crystal structure and physical and bactericidal properties. The Ca salt was a plate-shaped lamellar crystalline powder with a particle diameter of several micrometers to several tens of micrometers; it exhibited significant lubricity and alternative bactericidal activity against Staphylococcus aureus (S. aureus) and Propionibacterium acnes (P. acnes). We also examined other fatty acid Ca salts prepared from lauric acid (C12:0 fatty acid), palmitic acid (C16:0 fatty acid), and oleic acid (C18:1 fatty acid). The bactericidal activities and lubricity of the fatty acid Ca salts changed with the alkyl chain length and the degree of unsaturation. The C16:1 fatty acid Ca salt exhibited the strongest selective bactericidal ability among the four investigated fatty acid Ca salts. These findings suggest that C16:1 fatty acid and its Ca salt have potential applications in cleansing and cosmetic products.
authors.affiliation: Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Kijima
authors.forename: Toshiya
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yoshimune
authors.initials: Y
authors.lastname: Nonomura
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry*; D003358:Cosmetics; D003460:Crystallization; D003902:Detergents; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry*; D007474:Ion Exchange; D007850:Lauric Acids / Q000737:chemistry; D054327:Lubricants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019301:Oleic Acid / Q000737:chemistry; D019308:Palmitic Acid / Q000737:chemistry; D010316:Particle Size; D011208:Powders; D011425:Propionibacterium acnes / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D000900:Anti-Bacterial Agents; D003358:Cosmetics; D003902:Detergents; D005229:Fatty Acids, Monounsaturated; D007850:Lauric Acids; D054327:Lubricants; D011208:Powders; D014867:Water; C030358:lauric acid; C008757:palmitoleic acid; D019301:Oleic Acid; D019308:Palmitic Acid; D002118:Calcium