title: Interleukin-33 and Behçet disease: Another cytokine among others.
abstract: Since the discovery of interleukin-33 (IL-33) ligand for the ST2 receptor, scarce studies have implicated this cytokine in the pathogenesis of Behçet's disease (BD). IL-33 is member of the IL-1 superfamily of cytokines that is expressed by epithelial cells, endothelial cells, inflammatory cells and central nervous tissue. Its expression is upregulated following pro-inflammatory situations making IL-33 essential to innate immunity. IL-33 can function both as a traditional cytokine and as a nuclear factor regulating gene transcription. It is thought to function as an "alarmin" which is released following cell necrosis to alert the immune system of tissue damage or stress. This short review highlights the emerging roles of IL-33 protein and raises many interrogations about its involvement in BD.
authors: El Manar Tunis University, Faculty of Medicine of Tunis, Departement of Basic Sciences, Tunis, Tunisia; Unit Research 12SP15 "Homeostasis and Cell Dysfunction", Abderrahman Mami Hospital, Tunis El Manar University, Tunisia. Electronic address: kamel.hamzaoui@gmail.com.
authors: Kamel
authors: K
authors: Hamzaoui
authors: Unit Research 12SP15 "Homeostasis and Cell Dysfunction", Abderrahman Mami Hospital, Tunis El Manar University, Tunisia. Electronic address: eya.bouali@gmail.com.
authors: Eya
authors: E
authors: Bouali
authors: El Manar Tunis University, Faculty of Medicine of Tunis, Departement of Basic Sciences, Tunis, Tunisia; Unit Research 12SP15 "Homeostasis and Cell Dysfunction", Abderrahman Mami Hospital, Tunis El Manar University, Tunisia; Division of Pulmonology, Department of Paediatric Respiratory Diseases, Abderrahman Mami Hospital, Ariana, Tunisia. Electronic address: agnes.hamzaoui@gmail.com.
authors: Agnès
authors: A
authors: Hamzaoui
mesh_terms: D000818:Animals; D001528:Behcet Syndrome / Q000276:immunology*; D042783:Endothelial Cells / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000378:metabolism*; D007375:Interleukin-1 / Q000378:metabolism; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000276:immunology / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: C079241:IL1RL1 protein, human; D018836:Inflammation Mediators; D007375:Interleukin-1; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D011956:Receptors, Cell Surface
keywords: Alarmin; Behçet disease; IL-33; Inflammation; Innate and adaptive immunity; ST2