title: Detecting virulence and drug-resistance mycobacterial phenotypes in vivo.
abstract: Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metabolism and host-pathogen phenotypic interactions.
authors: Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. Electronic address: gtimmins@salud.unm.edu.
authors: Graham S
authors: GS
authors: Timmins
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D001944:Breath Tests / Q000379:methods*; D024881:Drug Resistance, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D008168:Lung / Q000382:microbiology*; D053858:Metabolic Networks and Pathways; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000378:metabolism* / Q000472:pathogenicity*; D010641:Phenotype; D014774:Virulence
chemical_list: D000995:Antitubercular Agents
keywords: bacteria; breath test; diagnosis; metabolism; phenotype