title: Genetic variations in the vitamin-D receptor (VDR) gene in preeclampsia patients in the Chinese Han population.
abstract: Previous studies have indicated that vitamin D deficiency is linked to a risk of preeclampsia (PE). The aim of our study was to investigate the association between genetic variations in the vitamin-D receptor (VDR) gene and the susceptibility to PE in the Chinese Han population. We examined the genotypes VDR rs2228570, rs11568820 and rs1544410 in 402 PE patients and 554 normal pregnant women in the third trimester by TaqMan allelic discrimination real-time polymerase chain reaction. The clinical data of the individuals were collected to enable genotype-phenotype analysis. A significant statistical difference in the genotypic frequencies of rs2228570 between cases and controls was found (χ(2)=13.750, P=0.001). The G allele was the risk factor for the risk of PE (χ(2)=9.456, P=0.002, OR=1.137, 95% CI 1.111-1.610). There was no difference in the genotypic and allelic distributions of rs11568820 and rs1544410 between the two groups (P&gt; 0.05). Our results provide evidence for a possible link between VDR and the development of PE in the Chinese Han population.
authors: Department of Obstetrics, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Ying
authors: Y
authors: Zhan
authors: Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Mengchun
authors: M
authors: Liu
authors: Department of Gynecology, People's Hospital of Haiyang City, Haiyang City, China.
authors: Yuelan
authors: Y
authors: You
authors: Department of Obstetrics, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Yan
authors: Y
authors: Zhang
authors: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Jingli
authors: J
authors: Wang
authors: Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Xunfeng
authors: X
authors: Wang
authors: 1] Department of Obstetrics, the Affiliated Hospital of Qingdao University, Qingdao, China [2] Prenatal diagnosis center, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Shiguo
authors: S
authors: Liu
authors: Department of Nephrology, the Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Xuemei
authors: X
authors: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D060888:Real-Time Polymerase Chain Reaction; D018167:Receptors, Calcitriol / Q000235:genetics*; D018570:Risk Assessment; D012959:Socioeconomic Factors
chemical_list: D018167:Receptors, Calcitriol; C579457:VDR protein, human