title: Protective effect of some selected fruit blends on testicular toxicity in alloxan-induced diabetic rats.
abstract: BACKGROUND
  The protective effect of a developed drink from blends of selected fruits on the sperm quality of alloxan-induced diabetic rats was investigated.
  
  
  METHODS
  Diabetes was intraperitoneally induced with alloxan; the formulated drink blend was orally administered 2.5 or 5 mL/day. Treatment lasted for 14 days and the rats were humanely sacrificed by cervical dislocation. The antioxidant status via assessment of reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and lipid peroxidation (LPO) was carried out on the testis, while sperm cells were analyzed for sperm motility, counts and abnormality.
  
  
  RESULTS
  Induction of diabetes led to a significant (p < 0.05) decrease in GSH level, elevated SOD and CAT activities, significant (p < 0.05) decrease in the sperm quality parameters studied. However, treatment with the formulated drink led to a significant (p < 0.05) reduction of LPO, SOD and CAT activities as well as increase in GSH level.
  
  
  CONCLUSIONS
  This study shows an improvement in testicular antioxidant activities and sperm qualities by single and double doses of the formulation, suggesting its protective potential against testicular toxicity in diabetic rats.
authors: Okukwe
authors: O
authors: Obode
authors: Oluwatoyin
authors: O
authors: Okafor
authors: Ochuko
authors: O
authors: Erukainure
authors: Atinuke
authors: A
authors: Ajayi
authors: Yewande
authors: Y
authors: Suberu
authors: Akinyele
authors: A
authors: Ogunji
authors: Teressa
authors: T
authors: Okporua
authors: Oluwatoyin
authors: O
authors: Oluwole
authors: Augusta
authors: A
authors: Ozumba
authors: Gloria
authors: G
authors: Elemo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D029441:Carica; D002374:Catalase / Q000378:metabolism; D002957:Citrus; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D005638:Fruit; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use; D031647:Psidium; D017208:Rats, Wistar; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D013733:Testicular Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D028321:Plant Preparations; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione