title: Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.
abstract: We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal disease and the study of renal physiology.
authors: †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
authors: Ryan M
authors: RM
authors: Williams
authors: †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
authors: Janki
authors: J
authors: Shah
authors: †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.
authors: Brandon D
authors: BD
authors: Ng
authors: ‡Weill Cornell Graduate School of Medical Sciences, New York, New York 10065, United States.
authors: Denise R
authors: DR
authors: Minton
authors: §Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, United States.
authors: Lorraine J
authors: LJ
authors: Gudas
authors: †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.|⊥Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065.
authors: Christopher Y
authors: CY
authors: Park
authors: †Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States.|§Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, United States.
authors: Daniel A
authors: DA
authors: Heller
mesh_terms: D000818:Animals; D004848:Epithelium / Q000737:chemistry*; D005260:Female; D007687:Kidney Tubules, Proximal / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D009928:Organ Specificity; D010316:Particle Size; D011092:Polyethylene Glycols / Q000138:chemical synthesis*; D011098:Polyglactin 910 / Q000138:chemical synthesis*; D014018:Tissue Distribution
chemical_list: D053769:Nanocapsules; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D011098:Polyglactin 910; D011092:Polyethylene Glycols
keywords: Nanotechnology; cancer; controlled release; nanomedicine; targeted drug delivery