title: [The role of adipose tissue in rheumatoid arthritis].
abstract: OBJECTIVE
  To estimate the frequency of obesity in a Russian cohort of patients with early rheumatoid arthritis (RA), determine adipocytokine (adiponectin, leptin) levels and their relation to RA activity.
  
  
  METHODS
  47 patients with early RA fulfilling ACR/EULAR(2010) criteria and using no BAID or GC. Mean age 57 [47;62] yr, duration of disease 7 [4;8] yr, median of DAS28 5.9 [5.3; 69]. Control group included 30 age-matched healthy donors. The degree of obesity was assessedfrom metabolic syndrome criteria (NCEP/ATPIII, RSSC, WHO); leptin and adiponectin were measured by ELISA, the L/A ratio was calculated.
  
  
  RESULTS
  Patients with RA had the same mean BMI but greater waist circumference (WC) and waist/hip ratio than controls (p=0.003 and p = 0.04). Obesity was diagnosed in 63.8 and 40% of the patients in these groups (p=0.04) based on NCEP/ ATPIII criteria and in 65.9 and 40% respectively by WHO criteria. The occurrence of obesity by RSSC criteria was not significantly different (p = 0.9). In patients with RA adiponectin level was higher (p=0.04) while leptin level and L/A ratio lower (p=0.02 and 0.003) than in controls. BMI correlated with ESR, CRB, DAS28, leptin and L/A (p<0.05) in both groups. ESR positively correlated with leptin level andA/L but negatively with adiponectin level (p<0.05).
  
  
  CONCLUSIONS
  The study showed high prevalence ofobesity in patients with early RA and its relation to inflammation. It was associated with increased serum adiponectin level, decreased leptin level and insulin resistance.
authors: L V
authors: LV
authors: Kondrat'eva
authors: Iu N
authors: IuN
authors: Gorbunova
authors: T V
authors: TV
authors: Popkova
authors: E L
authors: EL
authors: Nasonov
mesh_terms: D054392:Adipokines / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015897:Comorbidity; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D015995:Prevalence; D012107:Research Design; D012426:Russia / Q000453:epidemiology; D013223:Statistics as Topic; D055105:Waist Circumference
chemical_list: D054392:Adipokines; D015415:Biomarkers