title: [Pharmacotherapy and analysis of gaseous mediators in hypertensive patients].
abstract: OBJECTIVE
  To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension.
  
  
  METHODS
  Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists.
  
  
  RESULTS
  It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0.03) and the hydrogen sulphide concentration was significantly higher in hypertensive plasma in use of calcium channel antagonists (p<0.002).
  
  
  CONCLUSIONS
  The findings suggest that these medications have as additional action mechanism the improvement of endothelial dysfunction by elevate plasma levels of vasodilatory substances.
authors: University of São Paulo, Ribeirão Preto, SP, Brasil.
authors: Letícia Palota
authors: LP
authors: Eid
authors: Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.
authors: Renato Nery
authors: RN
authors: Soriano
authors: University of São Paulo, Ribeirão Preto, SP, Brasil.
authors: Marcelo Eduardo
authors: ME
authors: Batalhão
authors: Medical College of São José do Rio Preto, São José do Rio Preto, SP, Brazil.
authors: Lais Palotta
authors: LP
authors: Balderrama
authors: University of São Paulo, Ribeirão Preto, SP, Brazil.
authors: Evelin Capellari
authors: EC
authors: Carnio
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D009569:Nitric Oxide; D006862:Hydrogen Sulfide