title: Subtherapeutic serum quetiapine concentrations after absorption inhibition by binding resins: a case report.
abstract: OBJECTIVE
  Polystyrene sulfonate and sevelamer are binding resins that are used in the treatment of, respectively, hyperkalemia and hyperphosphatemia. It is unknown whether these resins interact with the antipsychotic quetiapine.
  
  
  METHODS
  We report on a woman with unexplainable low serum quetiapine concentrations who also used the binding resins polystyrene sulfonate and sevelamer. An In vitro binding assay showed binding of quetiapine by these resins. Separation of the ingestion times of quetiapine and the binding resins resulted in increased serum levels in this patient.
  
  
  CONCLUSIONS
  Polystyrene sulfonate and sevelamer are able to bind quetiapine. Healthcare professionals should be aware of this potential drug-drug interaction as this could lead to antipsychotic treatment failure.
authors: Department of Clinical Pharmacy, Deventer Hospital, Deventer, The Netherlands; Department of Clinical Pharmacy, Wilhelmina Hospital Assen, Assen, The Netherlands; Competence Centre for Translational Peptide Research U-PEP, Ulm, Germany.
authors: R H L
authors: RH
authors: Hoge
authors: M E L
authors: ME
authors: Arbouw
authors: S D W S
authors: SD
authors: Radstake
authors: I R F
authors: IR
authors: van Berlo-van de Laar
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002411:Cation Exchange Resins / Q000008:administration & dosage / Q000494:pharmacology; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D011137:Polystyrenes / Q000008:administration & dosage / Q000494:pharmacology; D000069348:Quetiapine Fumarate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000069603:Sevelamer / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D002411:Cation Exchange Resins; D002614:Chelating Agents; D011137:Polystyrenes; D000069348:Quetiapine Fumarate; C003321:polystyrene sulfonic acid; D000069603:Sevelamer
keywords: drug-drug interaction; quetiapine; sevelamer carbonate; sodium polystyrene sulfonate