title: Effect of non-surgical periodontal treatment on visfatin concentrations in serum and gingival crevicular fluid of patients with chronic periodontitis and type 2 diabetes mellitus.
abstract: BACKGROUND
  This study aims to assess visfatin concentrations in serum and gingival crevicular fluid (GCF) and investigate this relationship in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP) before and after non-surgical periodontal treatment.
  
  
  METHODS
  Fifty-four patients with T2DM and CP were recruited. The patients were randomly divided into two groups: treatment and control. Serum and GCF visfatin concentrations and glycated hemoglobin (HbA1c) levels were measured by enzyme-linked immunosorbent assay at different time points (at baseline and 3 and 6 months after non-surgical periodontal treatment).
  
  
  RESULTS
  Serum and GCF visfatin concentrations showed no significant differences between the groups at baseline (t test, P >0.05). A significant decline of visfatin in the treatment group was found in serum and GCF 3 months after non-surgical periodontal treatment (t test, P <0.01). Baseline and 3-month HbA1c levels were not significantly different, but at 6 months, a statistically significant difference was detected (t test, P >0.05).
  
  
  CONCLUSIONS
  The data suggest that non-surgical periodontal treatment is helpful for glucose control, an effect that may be associated with reduced visfatin in patients with T2DM and periodontitis. Furthermore, the data suggest that visfatin may be considered an inflammatory marker for periodontal diseases.
authors: *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.|†Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors: Yun
authors: Y
authors: Wu
authors: †Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors: Ling
authors: L
authors: Chen
authors: †Department of Stomatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
authors: Bin
authors: B
authors: Wei
authors: *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.
authors: Kai
authors: K
authors: Luo
authors: *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.|‡Nangjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, China.
authors: Fuhua
authors: F
authors: Yan
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D055113:Chronic Periodontitis / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D016207:Cytokines / Q000032:analysis / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000032:analysis / Q000097:blood*; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000097:blood / Q000378:metabolism / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000378:metabolism / Q000628:therapy
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D006442:Glycated Hemoglobin; D018836:Inflammation Mediators; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Adipokines; chronic periodontitis; diabetes mellitus; gingival crevicular fluid; nicotinamide phosphoribosyltransferase; nonsurgical periodontal debridement