title: Optical-resolution photoacoustic endomicroscopy in vivo.
abstract: Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA ; These authors contributed equally to this work.
authors: Joon-Mo
authors: JM
authors: Yang
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA ; These authors contributed equally to this work.
authors: Chiye
authors: C
authors: Li
authors: NIH Ultrasonic Transducer Resource Center, Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, University Park, Los Angeles, California 90089, USA ; These authors contributed equally to this work.
authors: Ruimin
authors: R
authors: Chen
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors: Bin
authors: B
authors: Rao
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors: Junjie
authors: J
authors: Yao
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors: Cheng-Hung
authors: CH
authors: Yeh
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA ; Currently with the Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
authors: Amos
authors: A
authors: Danielli
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors: Konstantin
authors: K
authors: Maslov
authors: NIH Ultrasonic Transducer Resource Center, Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, University Park, Los Angeles, California 90089, USA.
authors: Qifa
authors: Q
authors: Zhou
authors: NIH Ultrasonic Transducer Resource Center, Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, University Park, Los Angeles, California 90089, USA.
authors: K Kirk
authors: KK
authors: Shung
authors: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA.
authors: Lihong V
authors: LV
authors: Wang
keywords: (170.0170) Medical optics and biotechnology; (170.0180) Microscopy; (170.2150) Endoscopic imaging; (170.3880) Medical and biological imaging; (170.3890) Medical optics instrumentation; (170.5120) Photoacoustic imaging