title: CD105 expression in oral capillary hemangiomas and cavernous hemangiomas.
abstract: Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 (endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P < 0.01). These findings suggest that the biological characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary hemangiomas actively proliferated and were generally regulated by VEGF-A. In contrast, the ECs of cavernous hemangiomas lacked proliferative activity. These results suggest that angiogenesis and vasodilatation of pre-existing blood vessels are important in the development of capillary hemangioma and cavernous hemangioma, respectively.
authors: Department of Pathology, Nihon University School of Dentistry.
authors: Naoyuki
authors: N
authors: Matsumoto
authors: Motomi
authors: M
authors: Tsuchiya
authors: Shouta
authors: S
authors: Nomoto
authors: Yasuyoshi
authors: Y
authors: Matsue
authors: Yohichi
authors: Y
authors: Nishikawa
authors: Tsuyoshi
authors: T
authors: Takamura
authors: Hidero
authors: H
authors: Oki
authors: Kazuo
authors: K
authors: Komiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D002648:Child; D051546:Cyclooxygenase 2 / Q000378:metabolism; D000071063:Endoglin / Q000378:metabolism*; D005260:Female; D018324:Hemangioma, Capillary / Q000378:metabolism*; D006392:Hemangioma, Cavernous / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D000071063:Endoglin; D019394:Ki-67 Antigen; D042461:Vascular Endothelial Growth Factor A; D014841:von Willebrand Factor; D051546:Cyclooxygenase 2