title: Coenzyme Q₁₀, α-tocopherol, and oxidative stress could be important metabolic biomarkers of male infertility.
abstract: Oxidative stress, decreased antioxidant capacity, and impaired sperm mitochondrial function are the main factors contributing to male infertility. The goal of the present study was to assess the effect of the per os treatment with Carni-Q-Nol (440 mg L-carnitine fumarate + 30 mg ubiquinol + 75 IU vitamin E + 12 mg vitamin C in each softsule) in infertile men on sperm parameters, concentration of antioxidants (coenzyme Q10,  CoQ(10-TOTAL), γ, and α-tocopherols), and oxidative stress in blood plasma and seminal fluid. Forty infertile men were supplemented daily with two or three Carni-Q-Nol softsules. After 3 and 6 months of treatment, improved sperm density was observed (by 48.9% and 80.9%, resp.) and after 3-month treatment the sperm pathology decreased by 25.8%. Concentrations of CoQ(10-TOTAL) (ubiquinone + ubiquinol) and α-tocopherol were significantly increased and the oxidative stress was decreased. In conclusion, the effect of supplementary therapy with Carni-Q-Nol showed benefits on sperm function in men, resulting in 45% pregnancies of their women. We assume that assessment of oxidative stress, CoQ(10-TOTAL), and α-tocopherol in blood plasma and seminal fluid could be important metabolic biomarkers in both diagnosis and treatment of male infertility.
authors: Pharmacobiochemical Laboratory, Third Medical Department, Medical Faculty, Comenius University in Bratislava, Sasinkova Street 4, 811 08 Bratislava, Slovakia.
authors: Anna
authors: 0000-0002-5139-9213
authors: A
authors: Gvozdjáková
authors: Pharmacobiochemical Laboratory, Third Medical Department, Medical Faculty, Comenius University in Bratislava, Sasinkova Street 4, 811 08 Bratislava, Slovakia.
authors: Jarmila
authors: J
authors: Kucharská
authors: Urology Department, Comenius University in Bratislava, Limbová Street 5, 833 05 Bratislava, Slovakia.
authors: Jozef
authors: J
authors: Dubravicky
authors: Third Medical Department, Medical Faculty, Comenius University in Bratislava, Limbová Street 5, 833 05 Bratislava, Slovakia.
authors: Viliam
authors: V
authors: Mojto
authors: Halberg Hospital and Research Institute, Moradabad 244001, India.
authors: Ram B
authors: RB
authors: Singh
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002331:Carnitine / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005299:Fertility Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000188:drug therapy*; D008297:Male; D018384:Oxidative Stress; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000097:blood*
chemical_list: D015415:Biomarkers; C000603330:Carni-Q-Nol; D004338:Drug Combinations; D005299:Fertility Agents; D014451:Ubiquinone; D014810:Vitamin E; D024502:alpha-Tocopherol; C025203:Ubiquinone Q1; D001205:Ascorbic Acid; D002331:Carnitine