title: One-stage human acellular nerve allograft reconstruction for digital nerve defects.
abstract: Human acellular nerve allografts have a wide range of donor origin and can effectively avoid nerve injury in the donor area. Very little is known about one-stage reconstruction of digital nerve defects. The present study observed the feasibility and effectiveness of human acellular nerve allograft in the reconstruction of < 5-cm digital nerve defects within 6 hours after injury. A total of 15 cases of nerve injury, combined with nerve defects in 18 digits from the Department of Emergency were enrolled in this study. After debridement, digital nerves were reconstructed using human acellular nerve allografts. The patients were followed up for 6-24 months after reconstruction. Mackinnon-Dellon static two-point discrimination results showed excellent and good rates of 89%. Semmes-Weinstein monofilament test demonstrated that light touch was normal, with an obvious improvement rate of 78%. These findings confirmed that human acellular nerve allograft for one-stage reconstruction of digital nerve defect after hand injury is feasible, which provides a novel trend for peripheral nerve reconstruction.
authors: Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, China.
authors: Xue-Yuan
authors: XY
authors: Li
authors: Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, China.
authors: Hao-Liang
authors: HL
authors: Hu
authors: Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, China.
authors: Jian-Rong
authors: JR
authors: Fei
authors: Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, China.
authors: Xin
authors: X
authors: Wang
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Tian-Bing
authors: TB
authors: Wang
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Pei-Xun
authors: PX
authors: Zhang
authors: Department of Hand Surgery, Ningbo No.6 Hospital, Ningbo, Zhejiang Province, China.
authors: Hong
authors: H
authors: Chen
keywords: allograft; digital nerve; nerve conduit; nerve defect; nerve reconstruction; nerve regeneration; neural regeneration; peripheral nerve; sensory nerve