title: Decreased Expression of miR-15b in Human Gliomas is Associated with Poor Prognosis.
abstract: MicroRNA-15b (miR-15b) has been demonstrated to suppress proliferation by arresting cell cycle progression and inducing apoptosis in glioma cells. However, the prognostic value of miR-15b expression in human gliomas remains unclear. In the present study, the authors examined the expression profile in glioma specimens and the prognostic value of miR-15b in patients with gliomas. Real-time polymerase chain reaction assay was employed to detect the expression levels of miR-15b in 92 glioma tissues categorized by World Health Organization (WHO) histopathological grades. However, the prognostic value of miR-15b in human glioma has not been evaluated yet. MiR-15b expression in human glioma tissues was distinctly lower than in normal brain tissues. Furthermore, the expression of miR-15b notably decreased with the ascending histopathological grade of gliomas. Additionally, Kaplan-Meier survival analysis showed that low miR-15b expression was associated with poor overall survival in patients with gliomas. Similarly, miR-15b reduction occurred with increasing frequency in glioma patients with lower Karnofsky performance scale (KPS) scores than in those with higher KPS scores. No significant difference was observed between miR-15b expression and gender, age, and tumor location. These findings revealed that a lower expression level of miR-15b was closely related to a shorter overall survival, suggesting that miR-15b could be an intrinsic factor that plays an important role in the malignant progression of gliomas.
authors: 1 Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University , First People's Hospital of Yancheng, Yancheng, P.R. China .
authors: Guan
authors: G
authors: Sun
authors: Shushan
authors: S
authors: Yan
authors: Lei
authors: L
authors: Shi
authors: Zhengqiang
authors: Z
authors: Wan
authors: Nan
authors: N
authors: Jiang
authors: Min
authors: M
authors: Li
authors: Jun
authors: J
authors: Guo
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C505361:MIRN15 microRNA, human; D035683:MicroRNAs
keywords: glioma; miR-15b; microRNA; overall survival