title: Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium.
abstract: Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-α, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-α and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.
authors: Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan.|Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan.
authors: Hang
authors: H
authors: Wang
authors: Genomics Research Center, Academia Sinica, Taipei, Taiwan.
authors: Tsung-Lin
authors: TL
authors: Li
authors: Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan.
authors: Simon
authors: S
authors: Hsia
authors: Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung, Taiwan.
authors: I-Li
authors: IL
authors: Su
authors: Department of Life Science, Chinese Culture University, Taipei, Taiwan.
authors: Yi-Lin
authors: YL
authors: Chan
authors: Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan.|Center of Excellence for The Oceans, National Taiwan Ocean University, Keelung, Taiwan.
authors: Chang-Jer
authors: CJ
authors: Wu
mesh_terms: D000818:Animals; D001284:Atrophy; D002100:Cachexia / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006224:Cricetinae; D000077143:Docetaxel; D005395:Fish Oils / Q000494:pharmacology*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology*; D055435:Myostatin / Q000378:metabolism; D012643:Selenium / Q000494:pharmacology*; D043823:Taxoids / Q000009:adverse effects / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D005395:Fish Oils; D015850:Interleukin-6; C525912:Mstn protein, mouse; D055435:Myostatin; D043823:Taxoids; D014409:Tumor Necrosis Factor-alpha; D000077143:Docetaxel; D012643:Selenium
keywords: cachexia; chemotherapy; fish oil; muscle atrophy; selenium