title: Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production.
abstract: Adipose-derived stem cells (ADSCs) are multipotent cells that have attracted much recent attention. Here, we show that ADSCs enhance sphere formation and in vivo tumor initiation of breast and colon cancer cells. In co-culture, ADSCs induced several stem cell markers in cancer cells. ADSCs also accelerated tumor growth. Interaction of ADSCs and cancer cells stimulated secretion of interlukin-6 in ADSCs, which in turn acted in a paracrine manner on cancer cells to enhance their malignant properties. Interleukin-6 regulated stem cell-related genes and activated JAK2/STAT3 in cancer cells. We suggest that ADSCs may enhance tumor initiation and promotion.
authors: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.|Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan.
authors: Hong-Jian
authors: HJ
authors: Wei
authors: Department of Orthopedic Surgery, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
authors: Rong
authors: R
authors: Zeng
authors: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Jui-Hua
authors: JH
authors: Lu
authors: Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Wen-Fu T
authors: WF
authors: Lai
authors: Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan.
authors: Wei-Hong
authors: WH
authors: Chen
authors: Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan.
authors: Hen-Yu
authors: HY
authors: Liu
authors: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors: Ya-Ting
authors: YT
authors: Chang
authors: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.|Stem Cell Research Center, Taipei Medical University, Taipei, Taiwan.|Department of Orthopedic Surgery, The Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
authors: Win-Ping
authors: WP
authors: Deng
mesh_terms: D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology; D005260:Female; D064593:Heterografts; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D059630:Mesenchymal Stem Cells / Q000378:metabolism* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015850:Interleukin-6
keywords: adipose-derived stem cells; breast cancer; cancer stem cell; colon cancer; tumor initiation