title: [Plants as an alternative source of therapeutic proteins].
abstract: In recent years, there has been an increased interest of researchers in developing efficient plant heterologous expression systems of proteins for a wide range of applications. It represents an alternative to the traditional strategy utilizing bacterial, yeast, insect or mammalian cells. New techniques of identification and characterization and effective methods of plant genetic transformation allow the range of recombinant protein products to be expanded. Great expectations are associated with the use of plants as bioreactors for the production of specific proteins of therapeutic interest. This strategy offers a number of advantages, the most important being: the possibility of a significant reduction in production costs, the safety of the products obtained and full eukaryotic post-translational modifications of proteins. A group of proteins of special interest is pharmaceuticals, and a number of successful experiments have confirmed the possibility of obtaining heterogeneous proteins with therapeutic potential: monoclonal antibodies, vaccine antigens, and a variety of cytokines. This work is focused on selected recombinant proteins belonging to those groups expression of which was achieved in plant cells. These proteins may be used in the future for therapy or prevention of viral, bacterial or cancer diseases.
authors: Studentka V roku kier. Biotechnologia UŁ. Katedra Genetyki Ogólnej, Biologii Molekularnej i Biotechnologii Roślin, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki.
authors: Marta
authors: M
authors: Łucka
authors: Katedra Genetyki Ogólnej, Biologii Molekularnej i Biotechnologii Roślin, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki.
authors: Tomasz
authors: T
authors: Kowalczyk
authors: Zakład Biochemii Medycznej Uniwersytet Medyczny.
authors: Janusz
authors: J
authors: Szemraj
authors: Katedra Genetyki Ogólnej, Biologii Molekularnej i Biotechnologii Roślin, Wydział Biologii i Ochrony Środowiska, Uniwersytet Łódzki.
authors: Tomasz
authors: T
authors: Sakowicz
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D000941:Antigens / Q000096:biosynthesis*; D010940:Plant Proteins / Q000096:biosynthesis*; D030821:Plants, Genetically Modified / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*; D011499:Protein Processing, Post-Translational; D011994:Recombinant Proteins / Q000096:biosynthesis*; D022462:Vaccines, Edible / Q000096:biosynthesis*
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D010940:Plant Proteins; D011994:Recombinant Proteins; D022462:Vaccines, Edible