title: Histopathology and clinical course of MOG-antibody-associated encephalomyelitis.
abstract: We present histological, MRI, and clinical features of an adult patient with relapsing encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG). Furthermore, we report molecular details of the recognized epitope that is specific for human MOG. A brain biopsy revealed multiple sclerosis (MS)-type II pathology. Some features overlapped with both MS and neuromyelitis optica spectrum disorders (NMOSD), whereas others were distinct from both MS and NMOSD. Immunoadsorption and rituximab induced clinical stabilization. This case contributes a new, so far missing link in the emerging spectrum of MOG-antibody-associated encephalomyelitis.
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Melania
authors: M
authors: Spadaro
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Lisa Ann
authors: LA
authors: Gerdes
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Marie C
authors: MC
authors: Mayer
authors: Department of Radiology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Birgit
authors: B
authors: Ertl-Wagner
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Sarah
authors: S
authors: Laurent
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Markus
authors: M
authors: Krumbholz
authors: Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg 06120, Halle, Germany.
authors: Constanze
authors: C
authors: Breithaupt
authors: Department of Neurology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Tobias
authors: T
authors: Högen
authors: Department of Neurology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Andreas
authors: A
authors: Straube
authors: Department of Neuropathology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Armin
authors: A
authors: Giese
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
authors: Reinhard
authors: R
authors: Hohlfeld
authors: Department for Neuroimmunology, Center for Brain Research Vienna, Austria.
authors: Hans
authors: H
authors: Lassmann
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Edgar
authors: E
authors: Meinl
authors: Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.
authors: Tania
authors: T
authors: Kümpfel