title: Value of magnetic resonance imaging in evaluating the pancreatic allograft transplant complications.
abstract: OBJECTIVE
  To retrospectively investigate the value of magnetic resonance imaging (MRI) in detecting complications following pancreas transplant.
  
  
  METHODS
  Institutional review board approved this retrospective HIPAA-compliant study and waived informed patient consent. We identified all allograft pancreas transplant patients at our institution from 2001 to January 2014 who had all pertinent post-transplant imaging and clinical data available. Transplant type was documented. Patients were divided into two groups according to post-transplant period (group A; <12 months, group B; ≥12 months). We evaluated the parenchymal enhancement using contrast-enhanced MRI of the allograft and determined the mean percentage of parenchymal enhancement (MPPE) overall and in various abnormalities, the vessel patency, any peripancreatic fluid collection, and the ductal anatomy. We correlated these with clinical results using t test, χ (2), and Fisher's exact test; p < 0.05 was considered significant.
  
  
  RESULTS
  51 patients (34 male, mean age 43.7 years) were identified, 28 (55%) of whom had abnormal imaging findings; transplant rejection-related necrosis (n = 7), fluid collections (n = 7), vascular stenosis (n = 4), isolated venous thromboses (n = 3), acute pancreatitis (n = 3), pancreatic and peripancreatic abscesses (n = 2), pseudoaneurysm (n = 1), and small-bowel obstruction (n = 1). Pre vs. post-contrast pancreatic MPPE at 1 min was 120% in the normal allografts and 115% in the allografts with pancreatitis and without necrosis (p > 0.05). MPPE at 1 min was only 9% in the allografts rejections with necrosis/infarction. More complications were found in group A than group B (p < 0.05).
  
  
  CONCLUSIONS
  Contrast-enhanced MRI is useful for the non-invasive assessment of pancreas transplant complications.
authors: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, China. ybliu28@163.com.
authors: Yubao
authors: Y
authors: Liu
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. makisik@iupui.edu.
authors: Fatih
authors: F
authors: Akisik
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. atirkes@iupui.edu.
authors: Temel
authors: T
authors: Tirkes
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. matann@iupui.edu.
authors: Mark
authors: M
authors: Tann
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. ksandras@iupui.edu.
authors: Kumaresan
authors: K
authors: Sandrasegaran
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. sajennin@iupui.edu.
authors: S Gregory
authors: SG
authors: Jennings
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. clin1@iupui.edu.
authors: Chen
authors: C
authors: Lin
authors: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. bkakaral@iupui.edu.
authors: Bharat
authors: B
authors: Kakarala
authors: Department of Surgery, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. jfridell@iupui.edu.
authors: Jonathan A
authors: JA
authors: Fridell
authors: Department of Surgery, Indiana University School of Medicine, 550 N. University Blvd, Indianapolis, IN, 46202, USA. jpowelso@iupui.edu.
authors: John A
authors: JA
authors: Powelson
authors: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, 510080, China. cjr.lchh@vip.163.com.
authors: Changhong
authors: C
authors: Liang
mesh_terms: D000328:Adult; D064591:Allografts / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010179:Pancreas / Q000473:pathology* / Q000601:surgery*; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies
keywords: Complication; Magnetic resonance imaging; Pancreas transplant