title: Primin sensitization in north-eastern Italy: a temporal trend from 1996 to 2012.
abstract: BACKGROUND
  Primin is the main contact allergen found in the ornamental plant Primula obconica Hance.
  
  
  OBJECTIVE
  To analyse the temporal trend of sensitivity to primin in north-eastern Italy and to evaluate the associations with occupations in our geographical area.
  
  
  METHODS
  From 1996 to 2012, 24 052 consecutive patients with suspected allergic contact dermatitis were patch tested in north-eastern Italy. Individual characteristics were collected through a standardized questionnaire in eight departments of dermatology or occupational medicine.
  
  
  RESULTS
  The overall prevalence of primin sensitization was 1.9%; the prevalence was significantly higher in women (2.6%) than in men (0.5%). The Pordenone area had the higher prevalence of sensitization, which reached 6% in 1999-2001. We found a significant association between primin sensitization and household workers [odds ratio (OR) 2.3; 95% confidence interval (CI): 1.61-3.35], retired people (OR 1.8; 95%CI: 1.22-2.81), woodworkers (OR 2.1; 95%CI: 1.10-6.18), and chemical industry workers (OR 2.9; 95%CI: 1.05-8.29).
  
  
  CONCLUSIONS
  Our study showed that contact allergy to primin is still relevant in north-eastern Italy. The frequency of sensitization is decreasing, but for retired and household workers it is still >4%. Our results suggest the need to promote the use of primin-free P. obconica in Italy.
authors: Clinical Unit of Occupational Medicine, University of Trieste, Trieste, 34129, Italy.
authors: Lorenzo
authors: L
authors: Bongiorni
authors: Clinical Unit of Occupational Medicine, University of Trieste, Trieste, 34129, Italy.
authors: Andrea
authors: A
authors: Prodi
authors: Clinical Unit of Occupational Medicine, University of Trieste, Trieste, 34129, Italy.
authors: Francesca
authors: F
authors: Rui
authors: Sezione di Dermatologia Pediatrica, Dipartimento di Salute della Donna e del Bambino, University of Padova, Padova, 35100, Italy.
authors: Anna
authors: A
authors: Belloni Fortina
authors: Divisione di Dermatologia, Ospedale Santa Maria degli Angeli, Pordenone, 33170, Italy.
authors: Maria T
authors: MT
authors: Corradin
authors: Clinical Unit of Occupational Medicine, University of Trieste, Trieste, 34129, Italy.
authors: Francesca
authors: F
authors: Larese Filon
mesh_terms: D000328:Adult; D016227:Benzoquinones / Q000009:adverse effects*; D002617:Chemical Industry / Q000706:statistics & numerical data*; D015331:Cohort Studies; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006796:Household Work / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D066192:Manufacturing Industry / Q000706:statistics & numerical data*; D008875:Middle Aged; D010328:Patch Tests; D015995:Prevalence; D012179:Retirement / Q000706:statistics & numerical data*; D017678:Sex Distribution; D014934:Wood
chemical_list: D016227:Benzoquinones; C014773:primin
keywords: allergic contact dermatitis; epidemiology; occupational; patch test; primin