title: Longitudinal change in quantitative meniscus measurements in knee osteoarthritis--data from the Osteoarthritis Initiative.
abstract: OBJECTIVE
  We aimed to apply 3D MRI-based measurement technology to studying 2-year change in quantitative measurements of meniscus size and position.
  
  
  METHODS
  Forty-seven knees from the Osteoarthritis Initiative with medial radiographic joint space narrowing had baseline and 2-year follow-up MRIs. Quantitative measures were obtained from manual segmentation of the menisci and tibia using coronal DESSwe images. The standardized response mean (SRM = mean/SD change) was used as measure of sensitivity to longitudinal change.
  
  
  RESULTS
  Medial tibial plateau coverage decreased from 34.8% to 29.9% (SRM -0.82; p < 0.001). Change in medial meniscus extrusion in a central image (SRM 0.18) and in the central five slices (SRM 0.22) did not reach significance, but change in extrusion across the entire meniscus (SRM 0.32; p = 0.03) and in the relative area of meniscus extrusion (SRM 0.56; p < 0.001) did. There was a reduction in medial meniscus volume (10%; p < 0.001), width (7%; p < 0.001), and height (2%; p = 0.08); meniscus substance loss was strongest in the posterior (SRM -0.51; p = 0.001) and weakest in the anterior horn (SRM -0.15; p = 0.31).
  
  
  CONCLUSIONS
  This pilot study reports, for the first time, longitudinal change in quantitative 3D meniscus measurements in knee osteoarthritis. It provides evidence of improved sensitivity to change of 3D measurements compared with single slice analysis.
  
  
  CONCLUSIONS
  • First longitudinal MRI-based measurements of change of meniscus position and size. • Quantitative longitudinal evaluation of meniscus change in knee osteoarthritis. • Improved sensitivity to change of 3D measurements compared with single slice analysis.
authors: Institute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg; Salzburg, Strubergasse 21, A5020, Salzburg, Austria, katja.bloecker@pmu.ac.at.
authors: Katja
authors: K
authors: Bloecker
authors: W
authors: W
authors: Wirth
authors: A
authors: A
authors: Guermazi
authors: W
authors: W
authors: Hitzl
authors: D J
authors: DJ
authors: Hunter
authors: F
authors: F
authors: Eckstein
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D010865:Pilot Projects; D013977:Tibia / Q000473:pathology*