title: Optic disc drusen associated with optic nerve tumors.
abstract: OBJECTIVE
  To propose a theory based on clinical observation, namely, whether axonal distress induced by optic nerve tumors could be a triggering factor for optic disc drusen (ODD) formation.
  
  
  METHODS
  A 28-year-old woman with ODD and optic disc melanocytoma, a 53-year-old woman with ODD and optic nerve meningioma, and a 29-year-old woman with ODD and optic nerve glioma underwent comprehensive ophthalmologic examinations including spectral-domain optical coherence tomography, swept-source optical coherence tomography, visual field tests, color vision tests, and complete neurologic examinations including brain magnetic resonance imaging. In two cases, unilateral ODD existed on the same side of optic nerve tumors. In the bilateral case, the nerve that contained the tumor had ODD that were located more deeply and on both nasal and temporal sides of the optic nerve compared with the contralateral eye. In two cases, optic disc edema (ODE) was also present, and ODD persisted after ODE resolved.
  
  
  CONCLUSIONS
  Optic nerve tumors can trigger the formation of ODD, which suggests that ODD pathogenesis involves axonal flow distress in the optic nerve. The presence of asymmetric ODD and ODE may indicate the presence of an optic nerve tumor.
authors: *MD †MD, PhD Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea (all authors).
authors: Kyoung Min
authors: KM
authors: Lee
authors: Jeong-Min
authors: JM
authors: Hwang
authors: Se Joon
authors: SJ
authors: Woo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications* / Q000175:diagnosis; D008579:Meningioma / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000150:complications* / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D015594:Optic Disk Drusen / Q000175:diagnosis / Q000209:etiology*; D020339:Optic Nerve Glioma / Q000150:complications* / Q000175:diagnosis; D019574:Optic Nerve Neoplasms / Q000150:complications* / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D014787:Vision Tests; D058609:Visual Field Tests