title: Deaths associated with respiratory syncytial and influenza viruses among persons ≥5 years of age in HIV-prevalent area, South Africa, 1998-2009(1).
abstract: We estimated deaths attributable to influenza and respiratory syncytial virus (RSV) among persons >5 years of age in South Africa during 1998-2009 by applying regression models to monthly deaths and laboratory surveillance data. Rates were expressed per 100,000 person-years. The mean annual number of seasonal influenza-associated deaths was 9,093 (rate 21.6). Persons >65 years of age and HIV-positive persons accounted for 50% (n = 4,552) and 28% (n = 2,564) of overall seasonal influenza-associated deaths, respectively. In 2009, we estimated 4,113 (rate 9.2) influenza A(H1N1)pdm09-associated deaths. The mean of annual RSV-associated deaths during the study period was 511 (rate 1.2); no RSV-associated deaths were estimated in persons >45 years of age. Our findings support the recommendation for influenza vaccination of older persons and HIV-positive persons. Surveillance for RSV should be strengthened to clarify the public health implications and severity of illness associated with RSV infection in South Africa.
authors: Stefano
authors: S
authors: Tempia
authors: Sibongile
authors: S
authors: Walaza
authors: Cecile
authors: C
authors: Viboud
authors: Adam L
authors: AL
authors: Cohen
authors: Shabir A
authors: SA
authors: Madhi
authors: Marietjie
authors: M
authors: Venter
authors: Claire
authors: C
authors: von Mollendorf
authors: Jocelyn
authors: J
authors: Moyes
authors: Johanna M
authors: JM
authors: McAnerney
authors: Cheryl
authors: C
authors: Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007251:Influenza, Human / Q000453:epidemiology* / Q000266:history / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009975:Orthomyxoviridae; D011159:Population Surveillance; D015995:Prevalence; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000266:history / Q000401:mortality; D018113:Respiratory Syncytial Virus, Human; D012306:Risk; D013019:South Africa / Q000453:epidemiology; D055815:Young Adult
keywords: HIV; Influenza; RSV; South Africa; deaths; human immunodeficiency virus; mortality rates; respiratory syncytial virus; viruses