title: Potent therapeutic target of inflammation, virus and tumor: focus on interleukin-27.
abstract: Interleukin (IL)-27 is an important pleiotropic immunological regulator for having dual effects on the immune responses. Several distinct findings have been highlighted that in certain conditions, neutralizing IL-27 or its subunit IL-27p28 might be a useful strategy to limit inflammation. Recently more insights have revealed that IL-27 could also exert potent inhibitory functions in some other immune circumstances including virus infection and tumor immunity. In this review, we describe IL-27 receptor subunits and the mechanisms of individual IL-27, and summarize the advances of their preclinical application trials. In addition, the potential role of IL-27 as a clinical therapeutic target will also be discussed.
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
authors: Yuqing
authors: Y
authors: Duan
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
authors: Yunlong
authors: Y
authors: Jia
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
authors: Tingting
authors: T
authors: Wang
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
authors: Yu
authors: Y
authors: Wang
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China.
authors: Xiaonan
authors: X
authors: Han
authors: Department of Biotherapy, Fourth Hospital of Hebei Medical University and Hebei Cancer Institute, Shijiazhuang, China. Electronic address: cdlihualiu@aliyun.com.
authors: Lihua
authors: L
authors: Liu
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D006801:Humans; D064094:Interleukin-27 / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D014777:Virus Diseases / Q000276:immunology* / Q000628:therapy
chemical_list: D064094:Interleukin-27
keywords: Anti-tumor immunity; IL-27p28; Inflammation; Interleukin-27; Virus infection