title: Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster.
abstract: Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100-175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age.
authors: Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
authors: Rana
authors: R
authors: Begum
authors: Program of Neuroscience, Institute de Biologia, Universidade Federal Fluminense, Rio de Janeiro 24210130, Brazil.
authors: Karin
authors: K
authors: Calaza
authors: Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
authors: Jaimie Hoh
authors: JH
authors: Kam
authors: Institute of Ophthalmology, University College London, London EC1V 9EL, UK.
authors: Thomas E
authors: TE
authors: Salt
authors: Moorfields Eye Hospital, London EC1V 2PD, UK.
authors: Chris
authors: C
authors: Hogg
authors: Institute of Ophthalmology, University College London, London EC1V 9EL, UK g.jeffery@ucl.ac.uk.
authors: Glen
authors: G
authors: Jeffery
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000375:Aging / Q000502:physiology; D000818:Animals; D004331:Drosophila melanogaster; D007249:Inflammation; D007259:Infrared Rays; D008124:Locomotion / Q000528:radiation effects; D008136:Longevity / Q000528:radiation effects*; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D000255:Adenosine Triphosphate
keywords: ATP; fly; inflammation; lifespan