title: [The biochemical markers of hepatobiliary function in children under environmental pollution].
abstract: It has been carred out an analysis of biochemical parameters of the hepatobiliary system in 119 children who have been living in ecologically unfavourable districts in order to improve early diagnosis of environmentally triggered hepatobiliary disease. Our results found that 57.2% of patients from polluted region had early signs of liver dysfunction the most frequently of which was elevation of biochemical markers of cholestasis. Among the investigated enzymes the high frequency of abnormal levels of gamma-glutamyltransferase (54.6%) alkaline phosphatase (36.1%), sorbitol dehydrogenase (28.6%) were detected in children from ecologically unfavorable districts which may indicate that these markers were helpful for the early diagnosis of environmentally triggered hepatobiliary disease. It was revealed that almost every third child (41.1% examined children) from the ecologically unfavourable districts had decrease of liver detoxification enzyme activity (arginase).
authors: M V
authors: MV
authors: Lukach
authors: O Z
authors: OZ
authors: Hnateĭko
authors: N S
authors: NS
authors: Kosmynina
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D004784:Environmental Monitoring / Q000379:methods*; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008107:Liver Diseases / Q000175:diagnosis* / Q000201:enzymology* / Q000209:etiology; D008297:Male; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D007064:L-Iditol 2-Dehydrogenase; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase