title: Trisomy chromosome 6 as a sole cytogenetic abnormality in acute myeloid leukemia.
abstract: Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias. Isolated trisomy 6 is a rare abnormality, the prognostic significance of which is not well established. We report one case of acute myeloid leukemia (AML-M5 variant) with trisomy 6 as the sole cytogenetic abnormality. Previously, trisomy 6 has been reported in aplastic anemia, myelodysplastic syndrome, and AML, usually associated with hypocellular marrow. However, our patient had a very short history and hypercellular marrow infiltrated with blasts. We report this case due to the rarity of the condition. More studies are required to ascertain the role of trisomy 6 in the development of leukemia as well as in prognosis.
authors: All India Institute of Medical Sciences, Department of Hematology, New Delhi, India. E-mail: monikashashwat@hotmail.com.
authors: Monika
authors: M
authors: Gupta
authors: Nita
authors: N
authors: Radhakrishnan
authors: Manoranjan
authors: M
authors: Mahapatra
authors: Renu
authors: R
authors: Saxena