title: The -844 G>A PAI-1 polymorphism is associated with acute coronary syndrome in Mexican population.
abstract: BACKGROUND
  Acute coronary syndrome (ACS) has an important impact in public health with high morbidity and mortality. Prothrombotic and proinflammatory states are involved in the pathogenesis of the disease. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of the fibrinolysis and also is part of immune response. The -844 G>A gene polymorphism is related to increased PAI-1 protein levels. The aim of the study is to evaluate the association of -844 G>A PAI-1 polymorphism with ACS.
  
  
  METHODS
  A total of 646 individuals were recruited from Western Mexico: 350 unrelated healthy subjects and 296 patients with diagnosis of ACS.
  
  
  RESULTS
  The most important risk factor in our population was hypertension, followed by smoking. The genetic distribution showed an association of the A allele (OR = 1.27, P = 0.04) and AA genotype (OR = 1.86, P = 0.02) with ACS. The recessive model displayed similar results (OR = 1.76, P = 0.02). As additional finding, we observed significant differences in the genetic distribution of ACS dyslipidemic patients (OR = 1.99, P = 0.04). The A allele and AA genotype of -844 polymorphism of PAI-1 gene are risk factors for ACS. The AA genotype might be associated with the development of dyslipidemia in ACS patients.
authors: Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Ilian Janet
authors: IJ
authors: García-González
authors: Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Yeminia
authors: Y
authors: Valle
authors: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Elena
authors: E
authors: Sandoval-Pinto
authors: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Emmanuel
authors: E
authors: Valdés-Alvarado
authors: Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico ; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Angélica
authors: A
authors: Valdez-Haro
authors: Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: José Francisco
authors: JF
authors: Muñoz-Valle
authors: Centro Médico Nacional de Occidente, IMSS, 44350 Guadalajara, JAL, Mexico.
authors: Héctor Enrique
authors: HE
authors: Flores-Salinas
authors: Centro de Investigación Biomédica de Occidente, IMSS, 44350 Guadalajara, JAL, Mexico.
authors: Luis Eduardo
authors: LE
authors: Figuera-Villanueva
authors: Instituto de Investigación en Genética Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Nory Omayra
authors: NO
authors: Dávalos-Rodríguez
authors: Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44350 Guadalajara, JAL, Mexico.
authors: Jorge Ramón
authors: JR
authors: Padilla-Gutiérrez
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics*; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D020125:Mutation, Missense; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human