title: The expression level and prognostic value of Y-box binding protein-1 in rectal cancer.
abstract: The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis. The mean YB-1 histological scores for rectal cancer, rectal tubular adenoma, and rectitis tissue specimens were 205.5, 164.3, and 137.7, respectively. Shorter disease-free and overall survival times were found in patients with rectal cancer who had higher YB-1 expression than in those with lower expression (38.2 months vs. 52.4 months, P = 0.013; and 44.4 months vs. 57.3 months, P = 0.008, respectively). Our results indicate that YB-1 expression is higher in rectal cancer tissue than in rectal tubular adenoma and rectitis tissue and that it may be an independent prognostic factor for rectal cancer.
authors: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China; Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China.
authors: Yu
authors: Y
authors: Zhang
authors: Department of Surgery, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Ping-Wu
authors: PW
authors: Zhao
authors: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Gang
authors: G
authors: Feng
authors: Department of Pathology, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Gang
authors: G
authors: Xie
authors: Department of Pathology, MianYang Central Hospital, MianYang, People's Republic of China.
authors: An-Qun
authors: AQ
authors: Wang
authors: Department of Pathology, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Yong-Hong
authors: YH
authors: Yang
authors: Department of Surgery, LuZhou Medical College, LuZhou, People's Republic of China; Department of Surgery, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Dong
authors: D
authors: Wang
authors: Department of Oncology, MianYang Central Hospital, MianYang, People's Republic of China.
authors: Xiao-Bo
authors: XB
authors: Du
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology; D051840:Y-Box-Binding Protein 1 / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1