title: Vasculitis secondary to anti-C1q antibodies induced by Toxocariasis.
abstract: BACKGROUND
  Vasculitides occurring during parasitic infection are rare and may imply different mechanisms.
  
  
  METHODS
  A case report of cutaneous vasculitis and visceral damage during a larva migrans syndrome.
  
  
  RESULTS
  We report the case of a 64-year-old man who developed a purpura along with fever, respiratory failure, abdominal pain and myalgia. Immunological screening showed a high titer of both antinuclear antibodies and anti-double-stranded DNA antibodies along with anti-C1q antibodies. Toxocara canis serology returned highly positive with a positive western-blot. The use of antiparasitic drugs in combination with corticosteroids resulted in a dramatic improvement in the patient's condition.
  
  
  CONCLUSIONS
  Clinicians should be aware of the systemic complications that may occur during Toxocara canis infection, including vasculitis and immunological disorder.
authors: Department of Internal Medicine, Caen University Hospital, Caen, France. h.deboysson@ch-lisieux.fr.|Service de Médecine Interne, CHU côte de Nacre, avenue de la côte de Nacre, BP 95182, 14033, Caen Cedex 9, France. h.deboysson@ch-lisieux.fr.
authors: Hubert
authors: H
authors: de Boysson
authors: Department of Internal Medicine, Caen University Hospital, Caen, France.
authors: Nicolas
authors: N
authors: Martin Silva
authors: Department of Pathology, Caen University Hospital, Caen, France.
authors: François
authors: F
authors: Comoz
authors: Department of Internal Medicine, Caen University Hospital, Caen, France.
authors: Jonathan
authors: J
authors: Boutemy
authors: Department of Internal Medicine, Caen University Hospital, Caen, France.
authors: Boris
authors: B
authors: Bienvenu
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017166:Toxocara canis / Q000276:immunology*; D014120:Toxocariasis / Q000150:complications*; D016896:Treatment Outcome; D014657:Vasculitis / Q000175:diagnosis* / Q000473:pathology*
chemical_list: D000977:Antiparasitic Agents; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D015922:Complement C1q
keywords: Eosinophilia; Larva migrans; Toxocara cani(s); Vasculitis; c1q-antibody