title: International validation of a behavioral scale in Parkinson's disease without dementia.
abstract: The "Ardouin Scale of Behavior in Parkinson's Disease" is a new instrument specifically designed for assessing mood and behavior with a view to quantifying changes related to Parkinson's disease, to dopaminergic medication, and to non-motor fluctuations. This study was aimed at analyzing the psychometric attributes of this scale in patients with Parkinson's disease without dementia. In addition to this scale, the following measures were applied: the Unified Parkinson's Disease Rating Scale, the Montgomery and Asberg Depression Rating Scale, the Lille Apathy Rating Scale, the Bech and Rafaelsen Mania Scale, the Positive and Negative Syndrome Scale, the MacElroy Criteria, the Patrick Carnes criteria, the Hospital Anxiety and Depression Scale, and the Mini-International Neuropsychiatric Interview. Patients (n=260) were recruited at 13 centers across four countries (France, Spain, United Kingdom, and United States). Cronbach's alpha coefficient for domains ranged from 0.69 to 0.78. Regarding test-retest reliability, the kappa coefficient for items was higher than 0.4. For inter-rater reliability, the kappa values were 0.29 to 0.81. Furthermore, most of the items from the Ardouin Scale of Behavior in Parkinson's Disease correlated with the corresponding items of the other scales, depressed mood with the Montgomery and Asberg Depression Rating Scale (ρ=0.82); anxiety with the Hospital Anxiety and Depression Scale-anxiety (ρ=0.56); apathy with the Lille Apathy Rating Scale (ρ=0.60). The Ardouin Scale of Behavior in Parkinson's disease is an acceptable, reproducible, valid, and precise assessment for evaluating changes in behavior in patients with Parkinson's disease without dementia.
authors: CHU Clermont-Ferrand, Neurology Department; CHU Gabriel Montpied, Clermont-Ferrand, France; Université Clermont 1, UFR Medecine, EA7280, Clermont-Ferrand, France.
authors: Isabelle
authors: I
authors: Rieu
authors: Pablo
authors: P
authors: Martinez-Martin
authors: Bruno
authors: B
authors: Pereira
authors: Ingrid
authors: I
authors: De Chazeron
authors: Leo
authors: L
authors: Verhagen Metman
authors: Marjan
authors: M
authors: Jahanshahi
authors: Claire
authors: C
authors: Ardouin
authors: Isabelle
authors: I
authors: Chéreau
authors: Christine
authors: C
authors: Brefel-Courbon
authors: Fabienne
authors: F
authors: Ory-Magne
authors: Helene
authors: H
authors: Klinger
authors: Fleur
authors: F
authors: Peyrol
authors: Michael
authors: M
authors: Schupbach
authors: Kathy
authors: K
authors: Dujardin
authors: François
authors: F
authors: Tison
authors: Jean Luc
authors: JL
authors: Houeto
authors: Paul
authors: P
authors: Krack
authors: Franck
authors: F
authors: Durif
mesh_terms: D000368:Aged; D001526:Behavioral Symptoms / Q000175:diagnosis* / Q000209:etiology*; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000379:methods*; D015203:Reproducibility of Results
keywords: Parkinson's disease; clinical trials; neuropsychological and behavioral assessments; observational study; psychiatric disorders