title: Impact of newly developed, next-generation artificial endocrine pancreas.
abstract: BACKGROUND
  Recent studies have shown that strict perioperative blood glucose management may reduce mortality and morbidity in critically ill adult patients. The purpose of this study was to assess the accuracy and efficacy of the intraoperative application of a newly developed, next-generation artificial endocrine pancreas (STG-55, Nikkiso Co., Ltd., Tokyo, Japan).
  
  
  METHODS
  Twenty patients scheduled to undergo surgery were enrolled in this study. The STG-55 is designed to be more user-friendly than its conventional counterpart (STG-22) while maintaining the latter's fundamental functions, such as a closed-loop system using algorithms for insulin and glucose infusion. After anesthetic induction, a 20G intravenous catheter was inserted into a peripheral forearm vein and connected to a continuous blood glucose monitor. The resultant 105 scores for paired blood glucose values were compared by Bland-Altman analysis.
  
  
  RESULTS
  Stable blood glucose values were maintained automatically, and there were no complications related to use of the STG-55. A close correlation (r=0.96) was observed between continuous glucose measurements using the STG-55 and conventional intermittent glucose measurements. The difficulty of manipulation using this system was decreased by improved preparation procedures.
  
  
  CONCLUSIONS
  The glycemic control system using the STG-55 could provide an alternative way to achieve effective and safe perioperative glycemic control.
authors: Department of Anesthesiology, Tokushima University Hospital.
authors: Noriko
authors: N
authors: Kambe
authors: Shinji
authors: S
authors: Kawahito
authors: Naoji
authors: N
authors: Mita
authors: Kazumi
authors: K
authors: Takaishi
authors: Toshiko
authors: T
authors: Katayama
authors: Yoko
authors: Y
authors: Sakai
authors: Tomohiro
authors: T
authors: Soga
authors: Hiroaki
authors: H
authors: Kawano
authors: Munehide
authors: M
authors: Matsuhisa
authors: Mitsuo
authors: M
authors: Shimada
authors: Tetsuya
authors: T
authors: Kitagawa
authors: Hiroshi
authors: H
authors: Kitahata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001698:Biomedical Engineering; D001786:Blood Glucose / Q000378:metabolism; D004867:Equipment Design; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D007564:Japan; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D019397:Pancreas, Artificial
chemical_list: D001786:Blood Glucose