title: Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration.
abstract: Current advances in novel drug delivery systems (DDSs) to release growth factors (GFs) represent a great opportunity to develop new therapies or enhance the effectiveness of available medical treatments. These advances are particularly relevant to the field of regenerative medicine, challenging healthcare issues such as wound healing and skin repair. To this end, biocompatible biomaterials have been extensively studied to improve in vivo integration of DDSs, to enhance the bioactivity of the released drugs and to deliver bioactive molecules in a localised and controlled manner. Thus, this review presents an overview of DDSs to release GFs for skin regeneration, particularly emphasising on (i) polymeric micro and nanospheres, (ii) lipid nanoparticles, (iii) nanofibrous structures, (iv) hydrogels and (v) scaffolds. In addition, this review summarises the current animal models available for studying wound healing and the clinical trials and marketed medications based on GF administration indicated for chronic wound treatment.
  
  
  BACKGROUND
  Chronic wounds currently pose a significant burden worldwide. With advances in science, novel drug delivery systems have been developed for growth factors delivery. In this comprehensive review, the authors highlighted current drug delivery systems for the enhancement of wound healing and their use in clinical settings.
authors: NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
authors: Garazi
authors: G
authors: Gainza
authors: Biopraxis Research AIE, Miñano 01510, Spain.
authors: Silvia
authors: S
authors: Villullas
authors: NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
authors: José Luis
authors: JL
authors: Pedraz
authors: NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain.
authors: Rosa Maria
authors: RM
authors: Hernandez
authors: NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Vitoria, Spain. Electronic address: manoli.igartua@ehu.es.
authors: Manoli
authors: M
authors: Igartua
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D012038:Regeneration; D012867:Skin / Q000503:physiopathology*; D014945:Wound Healing
chemical_list: D006133:Growth Substances
keywords: Drug delivery system; Growth factor; Microparticle; Nanosphere; Skin regeneration; Wound healing