title: Serum and liver lipids distributions in streptozotocin induced diabetic rat treated with diet containing yam (Dioscorea bulbifera) flour.
abstract: BACKGROUND
  Liver disease as a major cause of mortality in patients with diabetes mellitus. There is a interest to investigate the hypolipidemic properties of yam. The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on serum and hepatic levels of triglycerides and cholesterol, in female diabetic rats.
  
  
  METHODS
  The rats were divided into three groups: Control (C), Diabetic (DM); Diabetic Yam (DMY), treated with diet containing 25g/100g of yam flour. After 5 weeks of experiment, glucose, insulin, gonadal fat and liver mass were evaluated. Serum and liver concentrations of triglycerides and cholesterol concentrations were quantified. Total liver thiols were determined.
  
  
  RESULTS
  After the 5 weeks, experimental groups shower (P < 0.05): Lower body mass; lower serum insulin; higher food intake and higher blood glucose concentration. DMY (vs. DM) group showed (P < 0.05): Lower blood glucose; higher gonadal fat mass; lower serum and hepatic triglycerides; higher hepatic cholesterol and thiols concentrations. DMY (vs. C) group showed: Similar serum and hepatic triglycerides and hepatic thiols.
  
  
  CONCLUSIONS
  Brazilian yam (Dioscorea bulbifera) alleviated the consequences of the experimental diabetic disease, suggesting protection to hypertriglyceridemia and lipid peroxidation.
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. leticiapessoa@id.uff.br.
authors: Letícia
authors: L
authors: Rozeno Pessoa
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. thais.nutricionista@ymail.com.
authors: Thaís de Salgado
authors: Tde S
authors: Rêgo
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. lou_asth@hotmail.com.
authors: Louise da Silva
authors: Lda S
authors: Asht
authors: Laboratory of Molecular Radiobiology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro.. igorccdrm@hotmail.com.
authors: Igor Cabral Coutinho do Rêgo
authors: IC
authors: Monteiro
authors: Laboratory of Molecular Radiobiology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro.. rsfortunato@yahoo.com.br.
authors: Rodrigo Soares
authors: RS
authors: Fortunato
authors: Bromatology Laboratory, College of Pharmacy, Federal Fluminense University, Niterói. Brazil.. marciabfeijo@globo.com.
authors: Márcia Barreto da Silva
authors: MB
authors: Feijó
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. andremcorreia@gmail.com.
authors: André Manoel
authors: AM
authors: Correia-Santos
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. carlosnut@ibest.com.br.
authors: Carlos Alberto Soares
authors: CA
authors: da Costa
authors: Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University.. gilsontb@gmail.com.
authors: Gilson Teles
authors: GT
authors: Boaventura
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism*; D027742:Dioscorea; D005260:Female; D005433:Flour; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D013438:Sulfhydryl Compounds