title: Effect of Slip Time in Forming Neo-Esophageal Stenosis After Replacement of a Thoracic Esophagus With Nitinol Artificial Esophagus.
abstract: Attempts have been made to investigate the effect of slip time of nitinol artificial esophagus for forming neo-esophageal stenosis after replacement of a thoracic esophagus with nitinol artificial esophagus in 20 experimental pigs. The pigs whose slip time was less than 90 days postoperatively had severe dysphagia (Bown's III) immediately after they were fed, and the dysphagia aggravated gradually later on (Bown's III-IV). The pigs whose slip time was more than 90 days postoperatively had mild/moderate dysphagia (Bown's I-II) immediately after they were fed, and the dysphagia relieved gradually later on (Bown's II-I-0). The ratios between the diameter of neo-esophagus in different slip time and normal esophagus were 25% (at 2 months postoperatively), 58% (at 4 months postoperatively), and 93% (at 6 months postoperatively), respectively. The relationship between nitinol artificial esophagus slip time and neo-esophageal stenosis showed a positive correlation. After replacement of a thoracic esophagus with nitinol artificial esophagus, the artificial esophageal slip time not only affected the original diameter of the neo-esophagus immediately, but also affected the neo-esophageal scar stricture forming process later on. The narrowing of neo-esophagus is caused by overgrowth of scar tissue. But there is the positive correlation between artificial esophagus slip time and neo-esophageal stenosis, so this can be a way of overcoming neo-esophageal stenosis by delaying slip time of artificial esophagus.
authors: Department of Thoracic Surgery, Insititute of Guangzhou Cardiovascular Diseases, Guangzhou Medical University, Guangzhou, China.
authors: Xian-Liang
authors: XL
authors: Liang
authors: Department of Thoracic Surgery, Insititute of Guangzhou Cardiovascular Diseases, Guangzhou Medical University, Guangzhou, China.
authors: Jian-Hui
authors: JH
authors: Liang
mesh_terms: D000497:Alloys / Q000009:adverse effects / Q000627:therapeutic use; D000818:Animals; D001187:Artificial Organs / Q000009:adverse effects; D004940:Esophageal Stenosis / Q000209:etiology* / Q000473:pathology; D004947:Esophagus / Q000473:pathology / Q000601:surgery*; D015607:Stents / Q000009:adverse effects; D013552:Swine
chemical_list: D000497:Alloys; C013616:nitinol
keywords: Artificial esophagus; Neo-esophageal stenosis; Nitinol; Relationship; Slip time