title: IL-17, IL-23, and p73 expression in cutaneous melanoma: a pilot study.
abstract: The incidence of cutaneous malignant melanoma is increasing worldwide, resulting in the demand for clinically useful prognostic biomarkers, especially for invasive and metastatic disease. We studied the immunohistochemical expression of interleukin-17 (IL-17), IL-23, and p73 in 35 malignant melanomas and compared them with benign melanocytic nevi and Spitz nevi, correlating them with clinical-pathological variables. A higher and statistically significant difference (P<0.05) in the intensity and percentage of stained cells of IL-17 and IL-23 was found in the melanoma group than in ordinary benign nevi that did not correlate with Breslow thickness nor Clark level. Moreover, p73 staining and percentage of stained cells was significantly higher (P<0.05) in all the melanomas studied, with a peculiar cytoplasmatic distribution. Our findings could suggest a possible IL-17, IL-23, and p73 involvement in cutaneous melanomas with a hypothetical impact on melanoma invasiveness.
authors: aDermatological Unit, Department of Clinical and Molecular Sciences bDepartment of Medical Sciences and Public Health, Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region, Ancona, Italy.
authors: Giulia
authors: G
authors: Ganzetti
authors: Corrado
authors: C
authors: Rubini
authors: Anna
authors: A
authors: Campanati
authors: Antonio
authors: A
authors: Zizzi
authors: Elisa
authors: E
authors: Molinelli
authors: Laura
authors: L
authors: Rosa
authors: Francesco
authors: F
authors: Simonacci
authors: Annamaria
authors: A
authors: Offidani
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D015331:Cohort Studies; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000378:metabolism*; D053760:Interleukin-23 Subunit p19 / Q000378:metabolism*; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism; D009506:Nevus / Q000378:metabolism / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D010865:Pilot Projects; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D015854:Up-Regulation; D000096142:Cutaneous Malignant Melanoma
chemical_list: D015415:Biomarkers; D004268:DNA-Binding Proteins; C508717:IL17A protein, human; C508840:IL23A protein, human; D020381:Interleukin-17; D053760:Interleukin-23 Subunit p19; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins