title: The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model.
abstract: Schizophrenia is a serious psychiatric illness with an unclear cause. One theory is that demyelination of white matter is one of the main pathological factors involved in the development of schizophrenia. The current study evaluated the protective effects of Areca catechu nut extract (ANE) on a cuprizone-induced demyelination mouse model. Two doses of ANE (1% and 2%) were administered orally in the diet for 8 weeks. Animals subjected to demyelination showed impaired spatial memory and less social activity. In addition, mice subjected to demyelination displayed significant myelin damage in cortex and demonstrated a higher expression of NG2 and PDGFRα and AMPK activation. ANE treatment not only significantly enhanced cognitive ability and social activity, but also protected myelin against cuprizone toxicity by promoting oligodendrocyte precursor cell (OPC) differentiation. In addition, ANE treatment demonstrated significant dephosphorylation of AMPKα, indicating a regulatory role for ANE in schizophrenia. This study showed that ANE treatment may enhance cognitive ability and social activity by facilitating OPC differentiation and protecting against myelin damage in cortex. Results also suggest the AMPK signaling pathway may be involved in this process.
authors: Xia Men Xian Yue Hospital, Xian Yue Road 387-399, Xiamen 361012, China ; Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, Canada T6G 2B7.
authors: Abulimiti
authors: 0000-0003-3259-6710
authors: A
authors: Adilijiang
authors: Department of Human Anatomy and Cell Science, Faculty of Medicine, University of Manitoba, 745 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0J9.
authors: Teng
authors: 0000-0001-9681-1243
authors: T
authors: Guan
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, Canada T6G 2B7.
authors: Jue
authors: J
authors: He
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, Canada T6G 2B7.
authors: Kelly
authors: K
authors: Hartle
authors: Xia Men Xian Yue Hospital, Xian Yue Road 387-399, Xiamen 361012, China.
authors: Wenqiang
authors: W
authors: Wang
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, 1E7.31 Walter C. Mackenzie Health Sciences Centre, Edmonton, AB, Canada T6G 2B7.
authors: XinMin
authors: X
authors: Li