title: The importance of rs1021737 and rs482843 polymorphisms of cystathionine gamma-lyase in the etiology of preeclampsia in the Caucasian population.
abstract: BACKGROUND
  Recently an increasing number of reports indicate the participation of genetic factors in the pathogenesis of preeclampsia (PE). The genes involved in the synthesis of nitric oxide that participates in the vasolidation, may play an important role in the development of this disorder. Hydrogen sulfide (H2S) which is produced by cystathionine gamma-lyase exhibits a similar effect to nitric oxide. It is suggested that certain polymorphisms of the CTH gene may participate in the development of chronic hypertension and preeclampsia.
  
  
  OBJECTIVE
  To evaluate the frequency of genotypes and alleles of rs1021737 and rs482843 polymorphisms of CTH gene in women with preeclampsia from Wielkopolska region.
  
  
  METHODS
  The study group consisted of 60 patients with diagnosed preeclampsia, into the control group 120 healthy pregnant women were enrolled. The examined rs1021737 and rs482843 polymorphisms of CTH gene were determined using PCR-RFLP method.
  
  
  RESULTS
  Analysis of rs482843 polymorphism in the CTH gene showed a statistically significant difference in the prevalence of mutated GG genotype (p<0.000001) and mutated G allele (p<0.000001) in the group of pregnant women with PE compared to the control group. There was no such correlation for the rs1021737 polymorphism. Furthermore, there are also no relationship between studied polymorphisms and selected clinical and biochemical parameters.
  
  
  CONCLUSIONS
  The results of rs482843 polymorphism analysis suggest that mutated GG genotype predisposes to preeclampsia occurrence. There was no such relationship for the rs1021737 polymorphism of CTH gene. Hence, further studies based on the determination of CSE expression level in women with PE may confirm the observed relationship between the rs482843 polymorphism and the risk of preeclampsia.
authors: Przemysław M
authors: PM
authors: Mrozikiewicz
authors: Anna
authors: A
authors: Bogacz
authors: Magdalena
authors: M
authors: Omielańczyk
authors: Hubert
authors: H
authors: Wolski
authors: Joanna
authors: J
authors: Bartkowiak-Wieczorek
authors: Edmund
authors: E
authors: Grześkowiak
authors: Bogusław
authors: B
authors: Czerny
authors: Krzysztof
authors: K
authors: Drews
authors: Agnieszka
authors: A
authors: Seremak-Mrozikiewicz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003542:Cystathionine gamma-Lyase / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000235:genetics; D017354:Point Mutation / Q000235:genetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D011295:Prenatal Care / Q000379:methods; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D003542:Cystathionine gamma-Lyase