title: Posterior subtenon triamcinolone acetonide injection as a primary treatment in eyes with acute Vogt-Koyanagi-Harada disease.
abstract: OBJECTIVE
  To investigate the effectiveness of isolated subtenon triamcinolone acetonide injection (STI) as a primary treatment in eyes with acute Vogt-Koyanagi-Harada (VKH) disease.
  
  
  METHODS
  Retrospective, observational, cross-sectional study.
  
  
  METHODS
  The data from 27 eyes in 14 patients with acute VKH treated with STI therapy were analysed retrospectively. The time course change in ocular inflammation, best corrected visual acuity (BCVA) and numbers of recurrences were examined.
  
  
  RESULTS
  STI led to prompt improvement of BCVA within a week after the primary treatment. After completing therapy, patients with VKH had improved BCVA compared with baseline. In six eyes of three patients (22.2%) treated with STI, ocular inflammation was refractory, or VKH was recurrent despite the treatment. There was significant difference between groups with and without recurrences of inflammation in the frequency of headaches before treatment. In the present study, 21 eyes of 11 patients (77.8%) achieved complete resolution of VKH without recurrence after STI therapy alone.
  
  
  CONCLUSIONS
  This study demonstrated that isolated STI therapy is a useful, minimally invasive, primary treatment option for patients with acute VKH without systemic disorders.
authors: Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan.
authors: Yoshikatsu
authors: Y
authors: Hosoda
authors: Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan.
authors: Hisako
authors: H
authors: Hayashi
authors: Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan.
authors: Shoji
authors: S
authors: Kuriyama
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003430:Cross-Sectional Studies; D004333:Drug Administration Routes; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014607:Uveomeningoencephalitic Syndrome / Q000188:drug therapy*; D014792:Visual Acuity
chemical_list: D000893:Anti-Inflammatory Agents; D014222:Triamcinolone Acetonide
keywords: Choroid; Inflammation; Retina; Treatment Medical