title: Large animal models of human cauda equina injury and repair: evaluation of a novel goat model.
abstract: Previous animal studies of cauda equina injury have primarily used rat models, which display significant differences from humans. Furthermore, most studies have focused on electrophysiological examination. To better mimic the outcome after surgical repair of cauda equina injury, a novel animal model was established in the goat. Electrophysiological, histological and magnetic resonance imaging methods were used to evaluate the morphological and functional outcome after cauda equina injury and end-to-end suture. Our results demonstrate successful establishment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgical repair of cauda equina injury.
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Wen-Tao
authors: WT
authors: Chen
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Pei-Xun
authors: PX
authors: Zhang
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Feng
authors: F
authors: Xue
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Xiao-Feng
authors: XF
authors: Yin
authors: Department of Radiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Cao-Yuan
authors: CY
authors: Qi
authors: Department of Radiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.
authors: Jun
authors: J
authors: Ma
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Bo
authors: B
authors: Chen
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: You-Lai
authors: YL
authors: Yu
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Jiu-Xu
authors: JX
authors: Deng
authors: Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing, China.
authors: Bao-Guo
authors: BG
authors: Jiang
keywords: NSFC grants; animal model; diagnosis; diffusion tensor imaging; fiber bundle; goat; injury; magnetic resonance imaging; nerve regeneration; neural regeneration; neuroimaging; physiology; radiography; spinal cord injury