title: Orientation to determine quality attributes of flavoring excipients containing volatile molecules.
abstract: Pharmaceutical excipients containing volatile odor-active molecules can be used in pharmaceutical development to increase patients' compliance. However, capturing the molecular composition of these odor-active substances is challenging. Therefore, guidance for the analytical investigation of these excipients should be developed. Using a model flavor, lead molecules were chosen and a gas chromatographic method was validated according to pharmaceutical guidelines. Changes during storage as well as batch homogeneity and conformity were investigated. The knowledge gained could be used to understand molecular differences between batches caused by aging. A suitable attempt to capture the volatile molecular composition of flavoring substance was presented and the found results could be used for the determination and interpretation of quality attributes.
authors: Heinrich-Heine-University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany(2).
authors: Florian E
authors: FE
authors: Kiene
authors: Heinrich-Heine-University Duesseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitaetsstrasse 1, 40225 Duesseldorf, Germany(2).
authors: Miriam
authors: M
authors: Pein
authors: TU Dortmund University, Department of Solids Process Engineering, Emil-Figge-Straße 68, 44227 Dortmund, Germany(1). Electronic address: Markus.Thommes@bci.tu-dortmund.de.
authors: Markus
authors: M
authors: Thommes
mesh_terms: D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas / Q000592:standards; D005079:Excipients / Q000032:analysis* / Q000592:standards; D005421:Flavoring Agents / Q000032:analysis* / Q000592:standards; D009812:Odorants / Q000032:analysis*; D011786:Quality Control; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000592:standards; D013997:Time Factors; D014835:Volatilization
chemical_list: D005079:Excipients; D005421:Flavoring Agents
keywords: Excipient; Flavor; Medicinal product; Quality attributes; Volatiles