title: Novel synthesis of a series of spiro 1,3-indanedione-fused dihydropyridines through the condensation of a tetrone with N-aryl/alkylenamines in presence of solid support silica sulfuric acid.
abstract: A convenient protocol for the library synthesis of biologically important 1-aryl-2',6-spiro(1',3'-indanedione)-1H-indeno[1,2-b]quinoline-5,7-diones has been developed. In this one-pot reaction protocol a tetrone is condensed with various N-aryl/alkylenamines of 1,3-cyclohexadiones on the surface of a solid-supported acid catalyst silica sulfuric acid under solvent-free condition. The significant advantages of this methodology are the use of solvent-free reaction conditions, operational simplicity of the reaction, good yield of the products with high atom economy, and employment of a recyclable catalyst. All these favorable factors make the present method convenient, economic, and 'benign by design'.
authors: Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata, 700 009, India.
authors: Ashis
authors: A
authors: Kundu
authors: Animesh
authors: A
authors: Pramanik
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D004095:Dihydropyridines / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013464:Sulfuric Acids / Q000737:chemistry*
chemical_list: C413384:1,2-indanedione; D000588:Amines; D004095:Dihydropyridines; D007189:Indans; D012997:Solvents; D013141:Spiro Compounds; D013464:Sulfuric Acids; D012822:Silicon Dioxide; C033158:sulfuric acid