title: Coenzyme Q10 inhibits the aging of mesenchymal stem cells induced by D-galactose through Akt/mTOR signaling.
abstract: Increasing evidences indicate that reactive oxygen species are the main factor promoting stem cell aging. Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in organ and cellular aging. However, the potential for CoQ10 to protect stem cell aging has not been fully evaluated, and the mechanisms of cell senescence inhibited by CoQ10 are still poorly understood. Our previous study had indicated that D-galactose (D-gal) can remarkably induce mesenchymal stem cell (MSC) aging through promoting intracellular ROS generation. In this study, we showed that CoQ10 could significantly inhibit MSC aging induced by D-gal. Moreover, in the CoQ10 group, the expression of p-Akt and p-mTOR was clearly reduced compared with that in the D-gal group. However, after Akt activating by CA-Akt plasmid, the senescence-cell number in the CoQ10 group was significantly higher than that in the control group. These results indicated that CoQ10 could inhibit D-gal-induced MSC aging through the Akt/mTOR signaling.
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Dayong
authors: D
authors: Zhang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Bingxi
authors: B
authors: Yan
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Shanshan
authors: S
authors: Yu
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Chong
authors: C
authors: Zhang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Baoming
authors: B
authors: Wang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Yayan
authors: Y
authors: Wang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Junbo
authors: J
authors: Wang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Zhanggen
authors: Z
authors: Yuan
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Lihuang
authors: L
authors: Zhang
authors: Department of Clinical Medicine, Zhejiang University City College School of Medicine, Hangzhou 310015, China.
authors: Jianping
authors: J
authors: Pan
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D005690:Galactose / Q000633:toxicity*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D050759:Cyclin-Dependent Kinase Inhibitor p21; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D014451:Ubiquinone; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases; C024989:coenzyme Q10; D005690:Galactose