title: Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum.
abstract: Nanomedicine has recently emerged as a better option for the treatment of various diseases. Here, we investigated the in vivo anticoccidial properties of zinc oxide nanoparticles (ZNPs). ZNPs were crystalline in nature, with a smooth and spherical surface and a diameter in the range of ~10-15 nm. The X-ray diffraction pattern was utilized to identify the crystalline property of the grown ZNPs, whereas field emission scanning electron microscopy was employed to check the size and morphology of the ZNPs. The data showed that mice infected with Eimeria papillata produced 29.7×10(3)±1,500 oocysts/g feces on day 5 postinfection. This output was significantly decreased, to 12.5×10(3)±1,000 oocysts, in mice treated with ZNPs. Infection also induced inflammation and injury of the jejunum. This was evidenced (1) through an increase in the inflammatory histological score, (2) through increased production of nitric oxide and malondialdehyde, and (3) through a decrease in both the glutathione level and goblet cell number in mice jejuna. All these infection-induced parameters were significantly altered during treatment with ZNPs. Our results indicate, therefore, that ZNPs have protective effects against E. papillata-induced coccidiosis.
authors: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia ; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
authors: Mohamed A
authors: MA
authors: Dkhil
authors: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors: Saleh
authors: S
authors: Al-Quraishy
authors: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors: Rizwan
authors: R
authors: Wahab
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D003048:Coccidiosis; D003049:Coccidiostats / Q000737:chemistry / Q000494:pharmacology; D004539:Eimeria / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000469:parasitology; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D015034:Zinc Oxide / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003049:Coccidiostats; D015034:Zinc Oxide
keywords: Eimeria; jejunum; mice; zinc nanoparticle