title: Ischaemia-modified albumin during experimental apnoea.
abstract: Ischaemia-modified albumin (IMA) is a marker of the release of reactive oxygen species (ROS) during hypoxaemia. In elite divers, breath-hold induces ROS production. Our aim was to evaluate the kinetics of IMA serum levels during apnea. Twenty breath-hold divers were instructed to perform a submaximal static breath-hold. Twenty non-diver subjects served as controls. Blood samples were collected at rest, every minute, at the end of breath-hold, and 10 min after recovery. The IMA level increased after 1 min of breath-hold (p < 0.003) and remained high until recovery. Divers were separated into 2 groups: subjects who held their breath for less than 4 min (G-4) and those who held it for more than 4 min (G+4). After 3 min of apnoea, the increase of IMA was higher in the G-4 group than in the G+4 group (p < 0.008). However, at the end of apnoea, the IMA level did not differ between groups. If IMA level was globally correlated with the apnoea duration, it is interesting to note that the higher IMA level was not found in the best divers. Similarly, if arterial blood oxygen saturation (SpO2) was globally inversely correlated with apnoea duration, the lowest SpO2 at the end of breath-hold was not found in the divers that performed the best apnoea. We concluded that these divers save their oxygen. The IMA level provides a useful measure of resistance to hypoxaemia.
authors: UMR MD2, Aix Marseille Université and Institut de Recherche Biomédicale des Armées, Faculty de Medicine Nord, boulevard Pierre Dramard 13015 Marseille, France., Université de Toulon et du Var, avenue de l'Université, B.P. 20132-83957 La Garde Cedex, France.
authors: Fabrice
authors: F
authors: Joulia
authors: Mathieu
authors: M
authors: Coulange
authors: Frederic
authors: F
authors: Lemaitre
authors: Agnelys
authors: A
authors: Desplantes
authors: Guillaume
authors: G
authors: Costalat
authors: Laurie
authors: L
authors: Bruzzese
authors: Frederic
authors: F
authors: Franceschi
authors: Bruno
authors: B
authors: Barberon
authors: Nathalie
authors: N
authors: Kipson
authors: Yves
authors: Y
authors: Jammes
authors: Régis
authors: R
authors: Guieu
mesh_terms: D000328:Adult; D001049:Apnea / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D062485:Breath Holding; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D015656:Respiratory Mechanics / Q000502:physiology; D012709:Serum Albumin; D000075462:Serum Albumin, Human
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D010100:Oxygen; D000075462:Serum Albumin, Human
keywords: albumine modifiée par l’ischémie; apnée; breath-hold; free-divers; hypoxia; hypoxie; ischaemia-modified albumin; plongeurs libres