title: Trends in susceptibility of Escherichia coli from intra-abdominal infections to ertapenem and comparators in the United States according to data from the SMART program, 2009 to 2013.
abstract: Antimicrobial resistance in Enterobacteriaceae, including resistance to carbapenems, is increasing worldwide. However, using U.S. Study for Monitoring Antimicrobial Resistance Trends (SMART) data for 2009 to 2013, no statistically significant decreasing susceptibility trends were found overall for Escherichia coli isolates from patients with intra-abdominal infections. In the subset of isolates from community-associated infections, susceptibility to levofloxacin decreased significantly and the increasing rate of multidrug-resistant E. coli approached statistical significance. In 2013, ertapenem, imipenem, and amikacin showed the highest susceptibility rates (≥99%) and fluoroquinolones the lowest (<70%). The 10 non-ertapenem-susceptible isolates (0.3% of all E. coli isolates) encoded one or more carbapenemases, extended-spectrum β-lactamases (ESBLs), AmpC β-lactamases, or non-ESBL β-lactamases.
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA shlob@ihmainc.com.
authors: Sibylle H
authors: SH
authors: Lob
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Krystyna M
authors: KM
authors: Kazmierczak
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Robert E
authors: RE
authors: Badal
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Meredith A
authors: MA
authors: Hackel
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Samuel K
authors: SK
authors: Bouchillon
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Douglas J
authors: DJ
authors: Biedenbach
authors: International Health Management Associates, Inc., Schaumburg, Illinois, USA.
authors: Daniel F
authors: DF
authors: Sahm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077727:Ertapenem; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D005838:Genotype; D006801:Humans; D059413:Intraabdominal Infections / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D014481:United States; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases; D000077727:Ertapenem