title: Acute and sub-chronic toxicity of glucose-cysteine Maillard reaction products in Sprague-Dawley rats.
abstract: Maillard reaction products (MRPs) derived from glucose-cysteine reactions have excellent anti-browning ability. However, there is a lack of information about their acute and sub-chronic toxicities. To our knowledge, the present study is the first to evaluate the acute and sub-chronic toxicities of MRPs in experimental animals. Acute toxicity testing and analysis by Horn's method showed that the median lethal oral dose (LD50) of MRPs in rats was 6.81 g/kg body weight. The sub-chronic toxicity test involved feeding rats with diet containing 0, 0.43, 0.85, or 1.70% (w/w) MRPs for 90 days. These treatments did not affect mortality, gross pathology, histology, hematology, or blood chemistry, and there were no dose-dependent changes in feed consumption. Based on these results, the dietary no-observed-adverse-effect level (NOAEL) for 90-day exposure was 1.29 and 1.51 g MRPs/kg body weight/day for male and female rats, respectively.
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Yixing
authors: Y
authors: Li
authors: Hainan Center for Disease Control & Prevention, Haikou 570203, China.
authors: Linliang
authors: L
authors: Su
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Fenfang
authors: F
authors: Li
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Chaozheng
authors: C
authors: Wang
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China. Electronic address: yuandebao@163.com.
authors: Debao
authors: D
authors: Yuan
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Jiao
authors: J
authors: Chen
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Lin
authors: L
authors: Tan
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Zhiqiang
authors: Z
authors: Jin
authors: Hainan Key Laboratory of Banana Genetic Improvement, Haikou Experimental Station, Chinese Academy of Tropical Agricultural Sciences, Haikou 570102, China.
authors: Weihong
authors: W
authors: Ma
mesh_terms: D000818:Animals; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005504:Food Analysis; D005947:Glucose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D015416:Maillard Reaction; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests
chemical_list: C085802:glucose-cysteine; D005947:Glucose; D003545:Cysteine
keywords: Acute oral toxicity; Maillard reaction products; Sub-chronic toxicity; Toxicity