title: [Expression of monocyte chemotactic protein-1 and its receptor in sudden coronary death].
abstract: OBJECTIVE
  To investigate the expression of monocyte chemotactic protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR-2) in coronary atherosclerosis plaques between sidden coronary death (SCD) and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group (non-SCD), control group (normal coronary artery) were detected by immunohistochemistry.
  
  
  RESULTS
  Positive rates of MCP-1 among the three groups were 78%, 47%, and 0%, respectively, with significant expressing differences between each two groups (P<0.05). Positive rates of CCR-2 among three groups were 72%, 47%, and 0%, respectively, with significant expressing differences between the SCD group and coronary atherosclerosis group as well as between the SCD group and control group (P<0.05), but with no significant expressing difference between coronary atherosclerosis group and control group (P>0.05).
  
  
  CONCLUSIONS
  Overexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated with SCD.
authors: Yuan-yuan
authors: YY
authors: Kuang
authors: Xia-xia
authors: XX
authors: Chen
authors: Cang-cheng
authors: CC
authors: Wang
authors: Kun
authors: K
authors: Ye
authors: Ying
authors: Y
authors: Wang
authors: Yong-hua
authors: YH
authors: Shi
mesh_terms: D018932:Chemokine CCL2 / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology; D016757:Death, Sudden, Cardiac / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D054390:Receptors, CCR2 / Q000378:metabolism*
chemical_list: D018932:Chemokine CCL2; D054390:Receptors, CCR2