title: Nerve biopsy findings contribute to diagnosis of multiple mononeuropathy: 78% of findings support clinical diagnosis.
abstract: Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and June 2013. Patients were diagnosed with vasculitic neuropathy (n = 6), perineuritis (n = 2), chronic inflammatory demyelinating polyradiculoneuropathy (n = 2) or Lewis-Sumner syndrome (n = 1) on the basis of clinical features, laboratory data, electrophysiological investigations and nerve biopsies. Two patients who were clinically diagnosed with vasculitic neuropathy and one patient who was clinically diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy were not confirmed by nerve biopsy. Nerve biopsies confirmed clinical diagnosis in 78.6% of the patients (11/14). Nerve biopsy pathological diagnosis is crucial to the etiological diagnosis of multiple mononeuropathy.
authors: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors: Ying-Shuang
authors: YS
authors: Zhang
authors: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors: A-Ping
authors: AP
authors: Sun
authors: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors: Lu
authors: L
authors: Chen
authors: Department of Pathology, Peking University Health Science Center, Beijing, China.
authors: Rong-Fang
authors: RF
authors: Dong
authors: Department of Pathology, Peking University Health Science Center, Beijing, China.
authors: Yan-Feng
authors: YF
authors: Zhong
authors: Department of Neurology, Peking University Third Hospital, Beijing, China.
authors: Jun
authors: J
authors: Zhang
keywords: Lewis-Sumner syndrome; asymmetrical sensory-motor polyneuropathy; inflammatory demyelinating polyradiculoneuropathy; multiple mononeuropathy; nerve regeneration; nonsystemic vasculitic neuropathy; perineuritis; peripheral nerve regeneration; peripheral nervous system; skin biopsy; sural nerve biopsy; systemic vasculitic neuropathy