title: Nanomedicine to overcome radioresistance in glioblastoma stem-like cells and surviving clones.
abstract: Radiotherapy is one of the standard treatments for glioblastoma, but its effectiveness often encounters the phenomenon of radioresistance. This resistance was recently attributed to distinct cell contingents known as glioblastoma stem-like cells (GSCs) and dominant clones. It is characterized in particular by the activation of signaling pathways and DNA repair mechanisms. Recent advances in the field of nanomedicine offer new possibilities for radiosensitizing these cell populations. Several strategies have been developed in this direction, the first consisting of encapsulating a contrast agent or synthesizing metal-based nanocarriers to concentrate the dose gradient at the level of the target tissue. In the second strategy the physicochemical properties of the vectors are used to encapsulate a wide range of pharmacological agents which act in synergy with the ionizing radiation to destroy the cancerous cells. This review reports on the various molecular anomalies present in GSCs and the predominant role of nanomedicines in the development of radiosensitization strategies.
authors: INSERM U1066, Bio-Inspired Micro and Nanomedicines (MINT), Angers, France; L'Université Nantes Angers Le Mans (LUNAM), Université d'Angers, Angers, France.
authors: Delphine
authors: D
authors: Séhédic
authors: INSERM U1066, Bio-Inspired Micro and Nanomedicines (MINT), Angers, France; L'Université Nantes Angers Le Mans (LUNAM), Université d'Angers, Angers, France.
authors: Annabelle
authors: A
authors: Cikankowitz
authors: INSERM U1066, Bio-Inspired Micro and Nanomedicines (MINT), Angers, France; L'Université Nantes Angers Le Mans (LUNAM), Université d'Angers, Angers, France; L'Université Nantes Angers Le Mans (LUNAM), PRIMEX, Université d'Angers, Angers, France.
authors: François
authors: F
authors: Hindré
authors: INSERM U892, Centre Régional de Recherche en Cancérologie Nantes/Angers (CRCNA), Nantes, France; L'Université Nantes Angers Le Mans (LUNAM), Université de Nantes, Nantes, France.
authors: François
authors: F
authors: Davodeau
authors: INSERM U1066, Bio-Inspired Micro and Nanomedicines (MINT), Angers, France; L'Université Nantes Angers Le Mans (LUNAM), Université d'Angers, Angers, France. Electronic address: emmanuel.garcion@univ-angers.fr.
authors: Emmanuel
authors: E
authors: Garcion
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D002999:Clone Cells / Q000528:radiation effects; D005909:Glioblastoma / Q000235:genetics / Q000532:radiotherapy*; D006801:Humans; D050997:Nanomedicine / Q000379:methods / Q000639:trends*; D014411:Neoplastic Stem Cells / Q000528:radiation effects*; D015398:Signal Transduction / Q000235:genetics / Q000528:radiation effects
keywords: glioblastoma; nanomedicine; radioresistance; radiosensitization; targeted therapies