title: Aripiprazole-induced chorioretinopathy: multimodal imaging and electrophysiological features.
abstract: OBJECTIVE
  To report the first documented case of aripiprazole-induced chorioretinopathy.
  
  
  RESULTS
  A 47-year-old schizophrenic patient with loss of vision due to an atypical retinopathy was investigated. She had been treated with aripiprazole for 8 years. Multimodal imaging showed in the right eye a large area of retinal atrophy predominating in the outer retina, including the posterior pole up to the upper temporal periphery, and in the left eye a serous retinal detachment. The electroretinogram exhibited decreased and delayed responses of both the rod and cone systems; the electrooculogram showed no light peak.
  
  
  CONCLUSIONS
  Aripiprazole, an atypical antipsychotic, was introduced more recently than the antipsychotics commonly incriminated in chorioretinopathies, such as thioridazine. Optical coherence tomography was not used to document former cases of antipsychotic-related chorioretinopathies. Although pathophysiological mechanisms are poorly understood, imaging of the present case points toward an involvement of the retinal pigmentary epithelium. Clinicians should be aware of the potential chorioretinal toxicity of new atypical antipsychotics.
authors: Ophtalmologie, Hôpital Privé Saint Martin, 18 rue des Roquemonts, 14000, Caen, France, celinefaureoph@gmail.com.
authors: Céline
authors: C
authors: Faure
authors: Isabelle
authors: I
authors: Audo
authors: Christina
authors: C
authors: Zeitz
authors: Jean-Bernard
authors: JB
authors: Letessier
authors: Matthieu P
authors: MP
authors: Robert
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D000068180:Aripiprazole; D004396:Coloring Agents; D003623:Dark Adaptation; D004585:Electrooculography; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008875:Middle Aged; D064847:Multimodal Imaging; D010879:Piperazines / Q000009:adverse effects*; D015363:Quinolones / Q000009:adverse effects*; D012160:Retina / Q000503:physiopathology*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D055213:Retinal Pigment Epithelium; D012559:Schizophrenia / Q000188:drug therapy; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D004396:Coloring Agents; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole; D007208:Indocyanine Green