title: Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents.
abstract: A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: Aby Cheruvathoor
authors: AC
authors: Poulose
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: Srivani
authors: S
authors: Veeranarayanan
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: M Sheikh
authors: MS
authors: Mohamed
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: Yutaka
authors: Y
authors: Nagaoka
authors: Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors: Rebeca Romero
authors: RR
authors: Aburto
authors: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors: Trevor
authors: T
authors: Mitcham
authors: Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.
authors: Pulickel M
authors: PM
authors: Ajayan
authors: Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
authors: Richard R
authors: RR
authors: Bouchard
authors: Biomedical Research Centre, Division of Analytical Science, Saitama Medical University, Saitama 350-0495, Japan.
authors: Yasushi
authors: Y
authors: Sakamoto
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: Yasuhiko
authors: Y
authors: Yoshida
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: Toru
authors: T
authors: Maekawa
authors: Bio Nano Electronics Research Centre, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan- 350-8585.
authors: D Sakthi
authors: DS
authors: Kumar
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis; D003300:Copper / Q000737:chemistry* / Q000528:radiation effects; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D054459:Elasticity Imaging Techniques / Q000379:methods; D006863:Hydrogen-Ion Concentration; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D008856:Microscopy, Fluorescence / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods*; D053769:Nanocapsules / Q000737:chemistry* / Q000528:radiation effects / Q000648:ultrastructure; D010778:Photochemotherapy / Q000379:methods*; D000068936:Theranostic Nanomedicine / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide