title: The significance of detection of serum miR-423-5p and miR-484 for diagnosis of colorectal cancer.
abstract: BACKGROUND
  Colorectal cancer (CRC) is a severe disease with considerable morbidity and mortality. Stable presence of miRNAs in serum enables them to be biomarkers for early diagnosis and surveillance of the progress of CRC.
  
  
  METHODS
  The blood samples of 53 CRC patients of I-IV stage pre therapy and 50 controlled healthy people were collected and total serum RNA was extracted. The level of miR-423-5p and miR-484 in serum were detected by qPCR.
  
  
  RESULTS
  In stage I-II CRC, serum miR-423-5p was significantly elevated compared with the control, whereas miR-484 was attenuated. In stage III-IV, no significance difference in miR-423-5p level was found between CRC patients and the control, and miR-484 level increased dramatically.
  
  
  CONCLUSIONS
  The study provides the possibility that the detection of miR-484-5p and miR-484 may be a useful method for early diagnosis and surveillance of the progress of CRC.
authors: Xiaodong
authors: X
authors: Lu
authors: Jia
authors: J
authors: Lu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged
chemical_list: D015415:Biomarkers; C548900:MIRN423 microRNA, human; C572386:MIRN484 microRNA, human; D035683:MicroRNAs