title: Synthesis, antimicrobial, anticancer evaluation of 2-(aryl)-4- thiazolidinone derivatives and their QSAR studies.
abstract: A new class of 4-thiazolidinones clubbed with quinozolinone nucleus has been synthesized. The title compounds were screened for their in vitro antimicrobial and anticancer potentials. Results of antimicrobial and anticancer study revealed that compounds 7 (pMICam = 1.69 μM/ml) and 2 (IC50 = 12.83 μM) were found to be the most potent antimicrobial and anticancer agents respectively. QSAR studies indicated that antimicrobial activity of synthesized 4-thiazolidinone derivatives was governed by the electronic parameters, dipole moment (μ), energy of highest occupied molecular orbital (HOMO), lipophilic parameter, log P and topological parameter, valence third order molecular connectivity index ((3)χ(v)).
authors: Aakash
authors: A
authors: Deep
authors: Pradeep
authors: P
authors: Kumar
authors: Balasubramanian
authors: B
authors: Narasimhan
authors: Kalavathy
authors: K
authors: Ramasamy
authors: Vasudevan
authors: V
authors: Mani
authors: Rakesh Kumar
authors: RK
authors: Mishra
authors: Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India. naru2000us@yahoo.com.
authors: Abu Bakar Abdul
authors: AB
authors: Majeed
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D045325:HCT116 Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D013844:Thiazoles