title: In vitro effect of sodium trimetaphosphate additives to conventional toothpastes on enamel demineralization.
abstract: OBJECTIVE
  The aim of this study was to evaluate the ability of conventional toothpastes (1100 ppm F) supplemented with sodium trimetaphosphate (TMP) in demineralization.
  
  
  METHODS
  Blocks of enamel were selected and then divided into seven experimental groups of 12: toothpaste without F and TMP (placebo), toothpaste with 1100 ppm F (1100), and toothpaste with 1100 ppm F supplemented with TMP-1 % (1100 1 % TMP), 3 % (1100 3 % TMP), 4.5 % (1100 4.5 % TMP), 6 % (1100 6 % TMP), and 9 % (1100 9 % TMP). Blocks were subjected to five pH cycles (demineralizing/remineralizing solutions) at 37 °C and treated with toothpaste slurries twice daily, after which the blocks were maintained for 2 days in fresh remineralizing solution. Following treatments, surface hardness (SHf) and cross-sectional hardness were determined for calculating the integrated loss of subsurface hardness (ΔKHN). The fluoride present in the enamel was also measured.
  
  
  RESULTS
  The SHf and ΔKHN measurements showed that supplementation with 3 % TMP was the most effective (p < 0.001) and showed greater concentration of F in the enamel (p < 0.001).
  
  
  CONCLUSIONS
  Addition of 3 % TMP to a conventional toothpaste (1100 ppm F) showed greater efficacy in reducing enamel demineralization.
  
  
  CONCLUSIONS
  Fluoride toothpastes containing trimetaphosphate possess good anticaries potential required to reduce the prevalence of dental caries in high-risk patients.
authors: Araçatuba School of Dentistry, Department of Pediatric Dentistry and Public Health, UNESP-Univ. Estadual Paulista, Rua José Bonifácio 1193, Araçatuba, SP, 16015-050, Brazil.
authors: Luciene Pereira
authors: LP
authors: de Castro
authors: Alberto Carlos Botazzo
authors: AC
authors: Delbem
authors: Marcelle
authors: M
authors: Danelon
authors: Amanda
authors: A
authors: Passarinho
authors: Célio
authors: C
authors: Percinoto
mesh_terms: D003743:Dental Enamel / Q000187:drug effects*; D006801:Humans; D011122:Polyphosphates / Q000009:adverse effects / Q000737:chemistry*; D012969:Sodium Fluoride / Q000009:adverse effects / Q000737:chemistry*; D014100:Toothpastes / Q000494:pharmacology*
chemical_list: D011122:Polyphosphates; D014100:Toothpastes; D012969:Sodium Fluoride; C009293:trimetaphosphoric acid