title: Efficacy and safety of perindopril arginine + amlodipine in hypertension.
abstract: To study the efficacy and safety of a new combination of perindopril arginine and amlodipine besylate, 837 subjects were enrolled in a three-arm, prospective, 59-center, randomized clinical trial. For 42 days, subjects (average seated blood pressure [BP], 158 ± 12/101 ± 5 mm Hg; age, 52 ± 10 years; 52% male; 34% black; 20% diabetic) received amlodipine/perindopril arginine (10/14 mg/d), perindopril erbumine (16 mg/d), or amlodipine (10 mg/d). Goal BP was <140/90 or <130/80 mm Hg in diabetics, per JNC 7 guidelines. The combination showed the largest change in seated BP (-23.7/-15.7 vs. -13.7/-9.5 vs. -19.3/-13.2 mm Hg, respectively; P < .0001), the highest proportion at goal BP (51% vs. 26% vs. 37%; P < .0001), and a lower incidence of pedal edema and adverse events compared with amlodipine. No deaths or significant differences across groups in early discontinuation, serum potassium, or rates of total or serious adverse events or glomerular filtration, were observed.
authors: Division of Pharmacology, Pacific Northwest University of Health Sciences, Yakima, WA, USA. Electronic address: wj.elliott@yahoo.com.
authors: William J
authors: WJ
authors: Elliott
authors: XOMA Corp., Berkeley, CA, USA.
authors: Jennifer
authors: J
authors: Whitmore
authors: XOMA Corp., Berkeley, CA, USA; Symplmed, Bend, OR, USA.
authors: Jeffrey D
authors: JD
authors: Feldstein
authors: ASH Comprehensive Hypertension Center, The University of Chicago Medicine, Chicago, IL, USA.
authors: George L
authors: GL
authors: Bakris
mesh_terms: D017311:Amlodipine / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004487:Edema / Q000517:prevention & control; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020913:Perindopril / Q000627:therapeutic use*; D011188:Potassium / Q000097:blood; D011446:Prospective Studies
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine; D011188:Potassium; D020913:Perindopril
keywords: Besylate; erbumine; pedal edema