title: Role of ovarian reserve markers, antimüllerian hormone and antral follicle count, as aneuploidy markers in ongoing pregnancies and miscarriages.
abstract: OBJECTIVE
  To assess the role of two ovarian reserve markers, antimüllerian hormone (AMH) and antral follicle count (AFC), as markers of the background risk for fetal trisomy.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Tertiary referral hospital.
  
  
  METHODS
  Assessment was carried out either in ongoing pregnancies or miscarriages in our center.
  
  
  METHODS
  AFC was assessed transvaginally during a routine (11-13 weeks) or referral scan. AMH was determined either during the first-trimester maternal serum markers assessment or in cases referred for chorionic villi sampling after the invasive procedure.
  
  
  METHODS
  AMH reference ranges were constructed according to maternal age, and AMH- and AFC-derived ovarian ages were compared among three different cytogenetic groups (normal karyotype, autosomal trisomies, and other chromosomal anomalies) in both ongoing pregnancies and miscarriages.
  
  
  RESULTS
  In autosomal trisomies, the median AFC-derived ovarian age was 3-5 years above the median maternal age. No differences were observed between AMH-derived ovarian age and maternal age.
  
  
  CONCLUSIONS
  AFC-derived ovarian biologic age reflects a more precise background risk for fetal aneuploidy that is not observed for AMH-derived age.
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Maribel
authors: M
authors: Grande
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Virginia
authors: V
authors: Borobio
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Mar
authors: M
authors: Bennasar
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Iosifina
authors: I
authors: Stergiotou
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Immaculada
authors: I
authors: Mercadé
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Narcís
authors: N
authors: Masoller
authors: Department of Gynecology and Reproduction, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain.
authors: Joana
authors: J
authors: Peñarrubia
authors: Department of Maternal-Fetal Medicine, Institute Gynecology, Obstetrics and Neonatology, Hospital Clínic Barcelona, Catalonia, Spain. Electronic address: aborrell@clinic.cat.
authors: Antoni
authors: A
authors: Borrell
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D008875:Middle Aged; D006080:Ovarian Follicle / Q000000981:diagnostic imaging*; D010050:Ovarian Function Tests / Q000379:methods*; D065851:Ovarian Reserve; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D062606:Tertiary Care Centers; D014314:Trisomy; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: Antral follicle count; aneuploid marker; antimüllerian hormone; maternal age; ovarian age