title: Association between resistin levels and all-cause and cardiovascular mortality: a new study and a systematic review and meta-analysis.
abstract: BACKGROUND
  Studies concerning the association between circulating resistin and mortality risk have reported, so far, conflicting results.
  
  
  OBJECTIVE
  To investigate the association between resistin and both all-cause and cardiovascular (CV) mortality risk by 1) analyzing data from the Gargano Heart Study (GHS) prospective design (n=359 patients; 81 and 58 all-cause and CV deaths, respectively); 2) performing meta-analyses of all published studies addressing the above mentioned associations.
  
  
  METHODS
  MEDLINE and Web of Science search of studies reporting hazard ratios (HR) of circulating resistin for all-cause or CV mortality.
  
  
  METHODS
  Performed independently by two investigators, using a standardized data extraction sheet.
  
  
  RESULTS
  In GHS, adjusted HRs per one standard deviation (SD) increment in resistin concentration were 1.28 (95% CI: 1.07-1.54) and 1.32 (95% CI: 1.06-1.64) for all-cause and CV mortality, respectively. The meta-analyses included 7 studies (n=4016; 961 events) for all-cause mortality and 6 studies (n=4,187: 412 events) for CV mortality. Pooled HRs per one SD increment in resistin levels were 1.21 (95% CI: 1.03-1.42, Q-test p for heterogeneity<0.001) and 1.05 (95% CI: 1.01-1.10, Q-test p for heterogeneity=0.199) for all-cause and CV mortality, respectively. At meta-regression analyses, study mean age explained 9.9% of all-cause mortality studies heterogeneity. After adjusting for age, HR for all-cause mortality was 1.24 (95% CI: 1.06-1.45).
  
  
  CONCLUSIONS
  Our results provide evidence for an association between circulating resistin and mortality risk among high-risk patients as are those with diabetes and coronary artery disease.
authors: Unit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
authors: Andrea
authors: A
authors: Fontana
authors: Endocrine Unit, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy; Scuola Superiore di Catania, University of Catania, Catania, Italy.
authors: Sara
authors: S
authors: Spadaro
authors: Unit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
authors: Massimiliano
authors: M
authors: Copetti
authors: CNR-IBIM and Nephrology, Dialysis and Transplantation Unit of Reggio Calabria, Reggio Calabria, Italy.
authors: Belinda
authors: B
authors: Spoto
authors: Research Unit of Diabetes and Endocrine Diseases, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
authors: Lucia
authors: L
authors: Salvemini
authors: CNR-IBIM and Nephrology, Dialysis and Transplantation Unit of Reggio Calabria, Reggio Calabria, Italy.
authors: Patrizia
authors: P
authors: Pizzini
authors: Endocrine Unit, Department of Clinical and Molecular Biomedicine, University of Catania, Catania, Italy.
authors: Lucia
authors: L
authors: Frittitta
authors: CNR-IBIM and Nephrology, Dialysis and Transplantation Unit of Reggio Calabria, Reggio Calabria, Italy.
authors: Francesca
authors: F
authors: Mallamaci
authors: Unit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
authors: Fabio
authors: F
authors: Pellegrini
authors: Research Unit of Diabetes and Endocrine Diseases, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
authors: Vincenzo
authors: V
authors: Trischitta
authors: Research Unit of Diabetes and Endocrine Diseases, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo, Italy.
authors: Claudia
authors: C
authors: Menzaghi
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D052243:Resistin / Q000097:blood*
chemical_list: D052243:Resistin