title: CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): a focus on its role in cancer.
abstract: The matricellular protein WISP1 is a member of the CCN protein family. It is induced by WNT1 and is a downstream target of β-catenin. WISP1 is expressed during embryonic development, wound healing and tissue repair. Aberrant WISP1 expression is associated with various pathologies including osteoarthritis, fibrosis and cancer. Its role in tumor progression and clinical outcome makes WISP1 an emerging candidate for the detection and treatment of tumors.
authors: Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland; University of Basel, Faculty of Science, Basel, Switzerland. Electronic address: Irem.Guerbuez@fmi.ch.
authors: Irem
authors: I
authors: Gurbuz
authors: Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland; University of Basel, Faculty of Science, Basel, Switzerland.
authors: Ruth
authors: R
authors: Chiquet-Ehrismann
mesh_terms: D000818:Animals; D055511:CCN Intercellular Signaling Proteins / Q000737:chemistry / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D055511:CCN Intercellular Signaling Proteins; C116396:CCN4 protein, human; D011518:Proto-Oncogene Proteins
keywords: CCN; Cancer; Metastasis; WISP; WNT1 inducible signaling pathway protein 1