title: [Role of protein carbamylation in chronic kidney disease complications].
abstract: Carbamylation corresponds to the non-enzymatic binding of isocyanic acid, mainly derived from urea decomposition, on amino groups of proteins, and participates in their molecular aging. This process is increased during chronic kidney disease (CKD) because of hyperuremia, and in other pathologies like atherosclerosis, where isocyanic may be formed from thiocyanate by myeloperoxidase in atheroma plates. Carbamylation triggers structural and functional modifications of proteins, thus impairing their biological roles and their interactions with cells. Much experimental evidence in vitro has shown the potential deleterious effects of carbamylated proteins on cell and tissue functions. Carbamylation-derived products (CDPs), and especially their major component homocitrulline, accumulate in organism in long half-life proteins, and may participate in the development of different complications of CKD, especially cardiovascular diseases, renal fibrosis, or nutritional and metabolic troubles. Recent clinical studies have confirmed the link between serum protein carbamylation and morbi-mortality in patients suffering from CKD or undergoing hemodialysis. Some CDPs could be used as biomarkers in these pathologies.
authors: Laboratoire de biologie et de recherche pédiatriques, hôpital Maison Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France; Laboratoire de biochimie médicale et biologie moléculaire, UMR CNRS/URCA n(o) 7369, faculté de médecine, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51095 Reims cedex, France. Electronic address: pgillery@chu-reims.fr.
authors: Philippe
authors: P
authors: Gillery
authors: Laboratoire de biologie et de recherche pédiatriques, hôpital Maison Blanche, CHU de Reims, 45, rue Cognacq-Jay, 51092 Reims cedex, France; Laboratoire de biochimie médicale et biologie moléculaire, UMR CNRS/URCA n(o) 7369, faculté de médecine, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51095 Reims cedex, France.
authors: Stéphane
authors: S
authors: Jaisson
authors: Laboratoire de biochimie médicale et biologie moléculaire, UMR CNRS/URCA n(o) 7369, faculté de médecine, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51095 Reims cedex, France.
authors: Laëtitia
authors: L
authors: Gorisse
authors: Laboratoire de biochimie médicale et biologie moléculaire, UMR CNRS/URCA n(o) 7369, faculté de médecine, université de Reims Champagne-Ardenne, 51, rue Cognacq-Jay, 51095 Reims cedex, France; Service de néphrologie-rhumatologie pédiatriques, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51092 Reims cedex, France.
authors: Christine
authors: C
authors: Pietrement
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D003485:Cyanates / Q000378:metabolism; D005355:Fibrosis; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D003485:Cyanates; D011506:Proteins; C005057:isocyanic acid
keywords: Carbamylation; Chronic kidney disease; Complications; Insuffisance rénale chronique; Modifications; Modifications post-traductionnelles non enzymatiques; Non-enzymatic post-translational protein ageing; Vieillissement protéique