title: Protective effect of ginger and zinc chloride mixture on the liver and kidney alterations induced by malathion toxicity.
abstract: This study was carried out on four groups of male Wistar rats, 10 rats per group. Group I got open access to food intake and water with normal balanced diet. Group II was administered 400 mg ginger per kg body weight (BW) and zinc chloride (ZnCl2) (300 mg/L) diluted in tap water for 4 months. Group III was administered malathion at a dose of 50 mg/kg BW/day in 0.2 mL corn oil via gavages for 4 months. This dose equal to 1/50 of the LD50. Group IV was given a mixture of 400 mg ginger per kg BW and ZnCl2 (300 mg/L) diluted in tap water in addition to 100 mg malathion/kg BW for 4 months. The liver showed histopathological changes include congestion, edema, and leucocytic infiltrations which were ameliorated by the addition of ginger and ZnCl2 mixture. The kidney showed cloudy swelling and hydropic degeneration of the renal tubules. These changes were ameliorated by the addition of ginger and ZnCl2 mixture. Ki67 immunoreactivity was localized in the cytoplasm and nuclear membrane. Its expression was estimated as the percentage of cells positively stained by the antibody in the different groups. In conclusion, malathion was toxic to the liver and kidney and must be avoided and protected by the addition of ginger and zinc mixture.
authors: Medical Laboratories, Department Faculty of Applied Medical Science, Tarabah branch, Taif University, Saudi Arabia Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt.
authors: Ahmed A
authors: AA
authors: Baiomy
authors: Medical Laboratories, Department Faculty of Applied Medical Science, Tarabah branch, Taif University, Saudi Arabia Histology Department, Faculty of Veterinary Medicine, Benha University, Qalyubia, Egypt drhossam222@hotmail.com.
authors: Hossam F
authors: HF
authors: Attia
authors: Medical Laboratories, Department Faculty of Applied Medical Science, Tarabah branch, Taif University, Saudi Arabia Biochemistry Department, Faculty of Veterinary Medicine, Benha University, Qalyubia, Egypt.
authors: Mohamed M
authors: MM
authors: Soliman
authors: Medical Laboratories, Department Faculty of Applied Medical Science, Tarabah branch, Taif University, Saudi Arabia Chemistry Department, Faculty of Science, Menoufia University, Al-Minufya, Egypt.
authors: Omar
authors: O
authors: Makrum
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008294:Malathion / Q000494:pharmacology*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017967:Zinc Compounds / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D010936:Plant Extracts; D020011:Protective Agents; D017967:Zinc Compounds; C016837:zinc chloride; D008294:Malathion
keywords: Ki67; ginger; kidney; liver; malathion; zinc chloride