title: Association of IL-6 polymorphism -174G/C and metabolic syndrome in hypertensive patients.
abstract: BACKGROUND
  Visceral obesity, the central core of metabolic syndrome (MetS), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. We investigated whether IL-6-174G/C gene polymorphism is associated with MetS prevalence in hypertensive patients.
  
  
  METHODS
  A population of hypertensive patients was included and stratified by the presence of MetS according to IDF criteria and evaluated by Framingham risk score. The IL-6-174G/C genotyping was performed by polymerase chain reaction and the prevalence of MetS was compared between "C" carrier and "non-C" carrier groups.
  
  
  RESULTS
  From an original sample of 664 patients, 612 (34.2% men, age 57.3 ± 10.1, 30.4% diabetics) were included. MetS was diagnosed in 51.3% of total population and "C" carriers demonstrated high prevalence of MetS (P < 0.05) and each of its components. On binary logistic regression, it was observed that the IL-6 polymorphism was independently associated with occurrence of MetS, even after adjusting for covariates (OR 1.13-2.37, 95% CI, P < 0.05).
  
  
  CONCLUSIONS
  The C allele at the -174 locus of IL-6 gene is independently associated with the occurrence of metabolic syndrome, emphasizing the importance of inflammatory genetic background in the pathogenesis of visceral obesity and related cardiovascular burden.
authors: Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil.
authors: Andrei Alkmim
authors: AA
authors: Teixeira
authors: Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil.
authors: Beata Marie Redublo
authors: BM
authors: Quinto
authors: Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil ; Nove de Julho University, 01156-050 São Paulo, SP, Brazil.
authors: Maria Aparecida
authors: MA
authors: Dalboni
authors: Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil.
authors: Cassio Jose de Oliveira
authors: CJ
authors: Rodrigues
authors: Nephrology Division, EPM, Universidade Federal de São Paulo (UNIFESP), 04039-032 São Paulo, SP, Brazil ; Nephrology Division, New England Medical Center, Tufts University, Boston, MA 02111, USA ; Research and Education Institute, Hospital Israelita Albert Einstein, 05652-900 São Paulo, SP, Brazil.
authors: Marcelo Costa
authors: MC
authors: Batista
mesh_terms: D000368:Aged; D000483:Alleles; D003920:Diabetes Mellitus / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000473:pathology; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6