title: Association of ApaI and BsmI polymorphisms with vitiligo risk: a meta-analysis.
abstract: BACKGROUND
  It has been reported that polymorphisms of the vitamin D receptor gene (VDR) such as ApaI or BsmI may affect the risk of vitiligo. However, the results have been inconsistent.
  
  
  OBJECTIVE
  To evaluate the association between two common polymorphisms (ApaI and BsmI) in the VDR gene and the susceptibility to vitiligo.
  
  
  METHODS
  The PubMed, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases were searched, and OR with 95% CI was calculated. The strength of association and vitiligo risk was assessed under five genetic models: allele, dominant, recessive, homozygous and heterozygous.
  
  
  RESULTS
  Six relevant studies were identified, including five studies that assessed the ApaI polymorphism and four the BsmI polymorphism (some overlapped). The meta-analysis results indicated that either the ApaI or the BsmI gene polymorphism may increase the risk of vitiligo in East Asian populations (aa + Aa vs. AA: OR = 1.40, 95% CI 1.01-1.96, P < 0.05; bb vs. Bb + BB: OR = 1.32, 95% CI 1.09-1.59, P < 0.01). No publication bias was detected in this meta-analysis.
  
  
  CONCLUSIONS
  The current meta-analysis suggests that the ApaI a allele or BsmI bb genotype are associated with the risk of vitiligo in East Asian populations. Thus, these polymorphisms could be potential biomarkers for early detection of vitiligo.
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: L
authors: L
authors: Li
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: Y
authors: Y
authors: Wu
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: L
authors: L
authors: Li
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: Y-F
authors: YF
authors: Cai
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: L
authors: L
authors: Geng
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: X-H
authors: XH
authors: Gao
authors: Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
authors: H-D
authors: HD
authors: Chen
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D012307:Risk Factors; D014820:Vitiligo / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases