title: A Pilot Study to Investigate the Efficacy of Fibrin Sealant (Tisseel®) in the Loop Electrosurgical Excision Procedure.
abstract: OBJECTIVE
  The objective of the current study was to evaluate the efficacy and feasibility of fibrin sealant (Tisseel®) in the loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN 2 or 3).
  
  
  METHODS
  We designed a single-blind, prospective, randomized study in 40 consecutive women undergoing LEEP for CIN 2 or 3 at our institute. Two milliliters of fibrin sealant (Tisseel) was applied to the uterine cervix of 20 women immediately after LEEP surgery (treatment group). We evaluated abdominal pain, vaginal bleeding, vaginal discharge and impairment in daily living after 1 week using visual analogue scale questionnaires and compared the results with those of 20 women who did not receive fibrin sealant (control group).
  
  
  RESULTS
  Among 40 women who returned for a follow-up 1 week after LEEP, 25 women (62.5%) reported at least one moderate to severe postprocedural symptom. The mean duration of moderate to severe vaginal bleeding and impairment in daily living during postoperative week 1 for the treatment group and the control group was 0.3 ± 0.80 versus 1.7 ± 2.36 days (p = 0.015) and 0.9 ± 1.37 versus 3.00 ± 2.62 days (p = 0.060), respectively.
  
  
  CONCLUSIONS
  Intraoperative application of fibrin sealant (Tisseel) in LEEP can decrease postoperative vaginal bleeding and impairment in daily living.
authors: Department of Obstetrics and Gynecology, School of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors: Jin Hwi
authors: JH
authors: Kim
authors: Tae Chul
authors: TC
authors: Park
authors: Geum Ae
authors: GA
authors: Park
authors: Jae Yeon
authors: JY
authors: Song
authors: Yeon Hee
authors: YH
authors: Kim
authors: Hee Joong
authors: HJ
authors: Lee
authors: Sung Jong
authors: SJ
authors: Lee
authors: Keun Ho
authors: KH
authors: Lee
authors: Soo Young
authors: SY
authors: Hur
authors: Jong Sup
authors: JS
authors: Park
mesh_terms: D015746:Abdominal Pain; D000203:Activities of Daily Living; D000328:Adult; D019092:Conization / Q000379:methods*; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D016037:Single-Blind Method; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D014592:Uterine Hemorrhage; D019522:Vaginal Discharge; D002578:Uterine Cervical Dysplasia / Q000601:surgery*
chemical_list: D015718:Fibrin Tissue Adhesive