title: Endothelial Dll4-Notch signaling in tumor microenvironment: is there any hidden therapeutic opportunity?
abstract: Tumor microenvironmental cross-talk between endothelial and cancer cells plays an essential role in growth, progression and therapeutic outcome of cancer. In response to tumor cell-derived vascular endothelial growth factor (VEGF), the endothelial delta-like ligand 4 (Dll4) regulates angiogenesis and tumor growth via Notch signaling. However, in view of intriguing effects of emerging Dll4-Notch signaling in various tumor types, the missing links need to be elucidated for development of this signaling as a possible therapeutic target for cancer therapy.
authors: Radiation Signaling and Cancer Biology Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.
authors: Amit
authors: A
authors: Kumar
authors: Radiation Signaling and Cancer Biology Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.
authors: Sejal
authors: S
authors: Desai
authors: Radiation Signaling and Cancer Biology Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.
authors: Badri N
authors: BN
authors: Pandey
keywords: Dll4-Notch receptor cross-talk; Tumor microenvironment; angiogenesis; cancer therapy; vascular endothelial growth factor signaling