title: Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice.
abstract: Oligonol is a phenolic product derived from lychee fruit extract containing catechin-type monomers and oligomers of proanthocyanidins, produced by a manufacturing process which converts polyphenol polymers into oligomers. These proanthocyanidins have been reported to exhibit beneficial bioactivities in many studies, and so oligonol, a rich source of polyphenol, is expected to show favorable effects on various chronic diseases. This article summarizes recent work whether oligonol has an ameliorative effect on diabetic indices and renal disorders associated with gluco-lipotoxicity-mediated oxidative stress, inflammation, and apoptosis in db/db mice with diabetes. Oligonol was able to improve diabetic indices, prevent the development of diabetic renal disease, and preserve renal cells and the renal morphological structure via the attenuation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced oxidative stress, inhibition of advanced glycation endproduct (AGE) generation, and prevention of apoptosis-induced cell death in db/db mice, being independent of changes in the body weight or serum glucose levels. The present study provides important evidence that oligonol exhibits a pleiotropic effect, representing renoprotective effects against the development of diabetic complications in type 2 diabetic db/db mice.
authors: College of Korean Medicine, Daegu Haany University.
authors: Chan Hum
authors: CH
authors: Park
authors: Jeong Sook
authors: JS
authors: Noh
authors: Hajime
authors: H
authors: Fujii
authors: Seong-Soo
authors: SS
authors: Roh
authors: Yeong-Ok
authors: YO
authors: Song
authors: Jae Sue
authors: JS
authors: Choi
authors: Hae Young
authors: HY
authors: Chung
authors: Takako
authors: T
authors: Yokozawa
mesh_terms: D000818:Animals; D017209:Apoptosis; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D017127:Glycation End Products, Advanced / Q000502:physiology; D007668:Kidney / Q000473:pathology; D050356:Lipid Metabolism; D032125:Litchi / Q000737:chemistry*; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D010636:Phenols; D017382:Reactive Oxygen Species; C514283:oligonol; D002392:Catechin