title: Nickel-catalyzed monofluoromethylation of aryl boronic acids.
abstract: Aryl boronic acids can be monofluoromethylated under nickel catalysis. The utility of this method is demonstrated by the monofluoromethylation of a borylated and acyl-protected derivative of the statin drug ezetimibe. Mechanistic investigations indicate that a fluoromethyl radical is involved in the Ni(I)/Ni(III) catalytic cycle.
authors: Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
authors: Yi-Ming
authors: YM
authors: Su
authors: Guang-Shou
authors: GS
authors: Feng
authors: Zhen-Yu
authors: ZY
authors: Wang
authors: Quan
authors: Q
authors: Lan
authors: Xi-Sheng
authors: XS
authors: Wang
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006845:Hydrocarbons, Fluorinated; D009942:Organometallic Compounds; D009532:Nickel
keywords: aryl boronic acid; catalysis; monofluoromethylation; nickel; radicals