title: High prevalence of bla(NDM-1) carbapenemase-encoding gene and 16S rRNA armA methyltransferase gene among Acinetobacter baumannii clinical Isolates in Egypt.
abstract: The main objective of this study was to decipher the molecular mechanism of resistance to carbapenems and aminoglycosides in a large series of 150 Acinetobacter baumannii clinical isolates collected from July 2012 to September 2013 in Egypt. We report for the first time the emergence of bla(NDM-1) and the cooccurrence of 16S rRNA methylase armA with bla(NDM-1) and bla(OXA-23) in Egyptian hospitals. Multilocus sequence typing identified 27 distinct sequence types, 11 of which were novel.
authors: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France Department of Microbiology and Immunology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), Cairo, Egypt.
authors: Mohamed Abd El-Gawad
authors: MA
authors: El-Sayed-Ahmed
authors: Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors: Magdy Ali
authors: MA
authors: Amin
authors: Department of Microbiology and Immunology, Faculty of Pharmacy, Misr University for Science and Technology (MUST), Cairo, Egypt.
authors: Wael Mustafa
authors: WM
authors: Tawakol
authors: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
authors: Lotfi
authors: L
authors: Loucif
authors: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France.
authors: Sofiane
authors: S
authors: Bakour
authors: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes (URMITE), UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille-Université, Marseille, France jean-marc.rolain@univ-amu.fr.
authors: Jean-Marc
authors: JM
authors: Rolain
mesh_terms: D040981:Acinetobacter baumannii / Q000235:genetics*; D004534:Egypt; D008780:Methyltransferases / Q000235:genetics; D058885:Multilocus Sequence Typing; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D012336:RNA, Ribosomal, 16S; D008780:Methyltransferases; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1