title: Quality-of-life issues in survivors to anaphylactic reactions to drugs.
abstract: The aim of this cross-sectional observational study was to explore quality of life and well-being in patients with drug-induced anaphylaxis. Two validated tools were used: the Drug Hypersensitivity Quality-of-Life Questionnaire (DrHy-Q) and the Psychological General Well-Being Index (PGWBI). Sixty-five patients (13 males) underwent data analysis. The mean DrHy-Q score was 62.82 ± 12.1. Mean PGWBI score was 64.03 ± 17.66. DrHy-Q score was significantly correlated with PGWBI total score (r = -0.314; P = 0.011) and with the following domains: Anxiety (r = -0.260; P = 0.036), Depressed mood (r = -0.406; P = 0.001), Positive well-being (r = -0.251; P = 0.004), and General Health (r = -0.352; P = 0.004). Compared with the Italian reference population, patients had a significantly reduced PGWBI total and domain score. Our results highlight for the first time how impaired HRQoL and distress commonly feature in survivors to anaphylactic reactions to drug.
authors: Allergy & Respiratory Diseases Clinic - DIMI - University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
authors: I
authors: I
authors: Baiardini
authors: Allergy Unit, Complesso Integrato Columbus, Rome, Italy.
authors: F
authors: F
authors: Gaeta
authors: Dipartimento di Scienze Umane e Sociali, Università della Valle d'Aosta, Aosta, Italy.
authors: G
authors: G
authors: Molinengo
authors: Allergy & Respiratory Diseases Clinic - DIMI - University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
authors: F
authors: F
authors: Braido
authors: Allergy & Respiratory Diseases Clinic - DIMI - University of Genoa, IRCCS AOU San Martino-IST, Genoa, Italy.
authors: G W
authors: GW
authors: Canonica
authors: Allergy Unit, Complesso Integrato Columbus, Rome, Italy.|IRCCS Oasi Maria S.S., Troina, Italy.
authors: A
authors: A
authors: Romano
mesh_terms: D000707:Anaphylaxis / Q000453:epidemiology* / Q000523:psychology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D011795:Surveys and Questionnaires; D017741:Survivors
keywords: anaphylaxis; drugs; quality of life; well-being