title: Historical overview of nuclear receptors.
abstract: This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.
authors: Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
authors: Jan-Ake
authors: JA
authors: Gustafsson
mesh_terms: D000818:Animals; D001671:Biochemistry / Q000266:history*; D003001:Cloning, Molecular; D004247:DNA / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D057093:Orphan Nuclear Receptors / Q000737:chemistry / Q000266:history* / Q000502:physiology; D011960:Receptors, Estrogen / Q000737:chemistry / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020218:Response Elements
chemical_list: D057093:Orphan Nuclear Receptors; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D004247:DNA
keywords: Domain structure; Orphan receptor; Steroid response element