title: Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate.
abstract: Interleukin-25 (IL-25) and IL-33, which belong to distinct cytokine families, induce and promote T helper type 2 airway inflammation. Both cytokines probably play a role in asthma, but there is a lack of direct evidence to clarify distinctions between their functions and how they might contribute to distinct 'endotypes' of disease. To address this, we made a direct comparison of the effects of IL-25 and IL-33 on airway inflammation and physiology in our established murine asthma surrogate, which involves per-nasal, direct airway challenge. Intranasal challenge with IL-33 or IL-25 induced inflammatory cellular infiltration, collagen deposition, airway smooth muscle hypertrophy, angiogenesis and airway hyper-responsiveness, but neither increased systemic production of IgE or IgG1. Compared with that of IL-25, the IL-33-induced response was characterized by more sustained laying down of extracellular matrix protein, neoangiogenesis, T helper type 2 cytokine expression and elevation of tissue damping. Hence, both IL-25 and IL-33 may contribute significantly and independently to asthma 'endotypes' when considering molecular targets for the treatment of human disease.
authors: The Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China.
authors: Yan
authors: Y
authors: Li
authors: The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors: Wei
authors: W
authors: Wang
authors: The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors: Ping
authors: P
authors: Huang
authors: The Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing.
authors: Qian
authors: Q
authors: Zhang
authors: The Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing.
authors: Xiujuan
authors: X
authors: Yao
authors: The Department of Laboratory Animal Sciences, Capital Medical University, Beijing, China.
authors: Jingjing
authors: J
authors: Wang
authors: The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors: Zhe
authors: Z
authors: Lv
authors: The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
authors: Yunqing
authors: Y
authors: An
authors: Division of Asthma, Allergy & Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
authors: Chris J
authors: CJ
authors: Corrigan
authors: The Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China.
authors: Kewu
authors: K
authors: Huang
authors: The Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.|Division of Asthma, Allergy & Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
authors: Sun
authors: S
authors: Ying
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D016326:Extracellular Matrix Proteins; C506535:Il33 protein, mouse; D007074:Immunoglobulin G; D000067596:Interleukin-33; D007378:Interleukins; C442281:Mydgf protein, mouse; D007073:Immunoglobulin E
keywords: asthma; interleukin-25; interleukin-33; remodelling