title: Digital Breast Tomosynthesis (DBT) to Characterize MRI-Detected Additional Lesions Unidentified at Targeted Ultrasound in Newly Diagnosed Breast Cancer Patients.
abstract: OBJECTIVE
  Preoperative breast magnetic resonance (MR) often generates additional suspicious findings needing further investigations. Targeted breast ultrasound (US) is the standard tool to characterize MR additional lesions. The purpose of this study is to evaluate the potential role of digital breast tomosynthesis (DBT) to characterize MR detected additional findings, unidentified at targeted breast US.
  
  
  METHODS
  This prospective study included women who a) had biopsy-proven, newly diagnosed breast cancers detected at conventional 2D mammography and/or US, referred to breast MR for tumour staging; and b) had DBT if additional MR findings were not detected at targeted ('second look') US.
  
  
  RESULTS
  In 520 patients, MR identified 164 (in 114 women, 22%) additional enhancing lesions. Targeted US identified 114/164 (69.5%) of these, whereas 50/164 (30.5%) remained unidentified. DBT identified 32/50 of these cases, increasing the overall characterization of MR detected additional findings to 89.0% (146/164). Using DBT the identified lesions were significantly more likely to be malignant than benign MR-detected additional lesions (p = 0.04).
  
  
  CONCLUSIONS
  DBT improves the characterization of additional MR findings not identified at targeted breast US in preoperative breast cancer staging.
  
  
  CONCLUSIONS
  • Targeted US identified 114 of 164 (69.5%) additional enhancing lesions at preoperative breast MRI. • DBT identified a further 32 of the 50 lesions unidentified on targeted US. • DBT improved the characterization of additional MR findings for breast cancer staging.
authors: Department of Diagnostic Imaging and Radiotherapy, A. O. U. Città della Salute e della Scienza of Turin, Breast Imaging Service, Radiology - University of Turin, Via Genova 3, 10126, Torino, Italy, giovanna.mariscotti@libero.it.
authors: Giovanna
authors: G
authors: Mariscotti
authors: Nehmat
authors: N
authors: Houssami
authors: Manuela
authors: M
authors: Durando
authors: Pier Paolo
authors: PP
authors: Campanino
authors: Elisa
authors: E
authors: Regini
authors: Alberto
authors: A
authors: Fornari
authors: Riccardo
authors: R
authors: Bussone
authors: Isabella
authors: I
authors: Castellano
authors: Anna
authors: A
authors: Sapino
authors: Paolo
authors: P
authors: Fonio
authors: Giovanni
authors: G
authors: Gandini
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D016217:Ultrasonography, Mammary