title: In vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against KPC-2-producing Enterobacteriaceae with high MICs for these antimicrobials.
abstract: We evaluated the in vitro activity of polymyxin B plus imipenem, meropenem, or tigecycline against six KPC-2-producing Enterobacteriaceae strains with high MICs for these antimicrobial agents. Polymyxin B with carbapenems, especially meropenem, were the most active combinations for Klebsiella pneumoniae and Enterobacter cloacae regardless of the polymyxin B concentration used in the time-kill assay. This combination was also synergistic against two Serratia marcescens strains that are intrinsically resistant to polymyxins. Polymyxin B and tigecycline also presented synergistic activity in most experiments.
authors: Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors: Natália
authors: N
authors: Barth
authors: Laboratório de Pesquisa em Resistência Bacteriana, LABRESIS, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Universidade Federal do Pampa (Unipampa), Campus Uruguaiana, Uruguaiana, Brazil.
authors: Vanessa B
authors: VB
authors: Ribeiro
authors: Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil Department of Internal Medicine, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil azavascki@hcpa.ufrgs.br.
authors: Alexandre P
authors: AP
authors: Zavascki
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology*; D015378:Imipenem / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D011112:Polymyxin B / Q000494:pharmacology*; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology; D013845:Thienamycins / Q000494:pharmacology*; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013845:Thienamycins; D000078304:Tigecycline; D015378:Imipenem; D001618:beta-Lactamases; D000077731:Meropenem; D008911:Minocycline; D011112:Polymyxin B