title: [Factors affecting oxidative damage in obese children: an exploratory study].
abstract: BACKGROUND
  Obesity is a metabolic disorder that creates oxidizing conditions, which can generate high levels of physiological stress as well as a disturbance in the state of redox cell known as Oxidative Stress.
  
  
  OBJECTIVE
  To examine the association between the damage on chromosomal DNA and the total antioxidant capacity (TAC) in obese children with severe obesity.
  
  
  METHODS
  Participants were 11 children with a mean age and body mass index of 9.5±1.2 years and 27.7±3.3 kg/m2, respectively, from which venous blood samples were obtained to determine distinctive risk factors of metabolic syndrome, the number of DNA abasic sites (AS) and TAC levels. Biomarkers were quantified from spectrophotometric techniques and ELISA assays.
  
  
  RESULTS
  Were identified 4.1±4.0x105 AS and TAC of 0.218±0.03 mmol/L, and an inverse correlation between AS and TAC (r = -0.63, p=0.038). These results suggest an imbalance in reduction-oxidation status (REDOX) within the cell.
  
  
  CONCLUSIONS
  Increased AS and decreased TAC concentrations in the presence of severe obesity suggest that oxidative stress could be considered as an important risk factor closely linked to the early development of comorbidities associated to obesity.
authors: Facultad de Deportes Campus Ensenada. Universidad Autónoma de Baja California.. ivanren93@gmail.com.
authors: Ivan
authors: I
authors: Rentería
authors: Facultad de Deportes Campus Ensenada. Universidad Autónoma de Baja California. Escuela de Ciencias de la Salud Campus Ensenada. Universidad Autónoma de Baja California.. earenas@uabc.edu.mx.
authors: Ever
authors: E
authors: Arenas Berumen
authors: Facultad de Ciencias Campus Ensenada. Universidad Autónoma de Baja California. Ensenada, B.C.. evarista.arellano@uabc.edu.mx.
authors: María Evarista
authors: ME
authors: Arellano García
authors: Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua.. ccarrasco@uach.mx.
authors: Claudia Esther
authors: CE
authors: Carrasco-Legleu
authors: Facultad de Ciencias de la Cultura Física, Universidad Autónoma de Chihuahua.. gdeleon@uach.mx.
authors: Lidia Guillermina
authors: LG
authors: De León-Fierro
authors: Servicios de Salud Pública del Distrito Federal. México.. arenasberumene@yahoo.com.
authors: Enrique Alejandro
authors: EA
authors: Arenas-Berumen
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D004249:DNA Damage; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D000975:Antioxidants