title: Correlations between extent of X-ray infiltration and levels of serum C-reactive protein in adult non-severe community-acquired pneumonia.
abstract: Pneumonia cases can vary in both severity and chest X-ray findings. Elevated C-reactive protein (CRP) levels may be an indicator of disease severity. We retrospectively evaluated factors correlated with the extent of chest X-ray infiltration both in community-acquired pneumonia (CAP) and a subgroup of cases with pneumococcal pneumonia. In a clinical study that evaluated the efficacy of sitafloxacin, 137 patients with CAP had been previously enrolled. In our study, 75 patients with pneumococcal pneumonia were identified among these 137 CAP patients. The extent of chest X-ray infiltration was scored and correlations with age, sex, body temperature, white blood cell (WBC) count, and CRP levels were analyzed using multivariate analysis with logistic regression. Significant correlations were observed between the extent of chest X-ray infiltration and CRP levels in both CAP and pneumococcal pneumonia. Our data indicates that CRP is a valuable and informative resource that could reflect the severity of pneumonia in cases of both CAP and pneumococcal pneumonia.
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan. Electronic address: h066576@med.u-ryukyu.ac.jp.
authors: Maki
authors: M
authors: Tamayose
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Jiro
authors: J
authors: Fujita
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Gretchen
authors: G
authors: Parrott
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Kazuya
authors: K
authors: Miyagi
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Tatsuji
authors: T
authors: Maeshiro
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Tetsuo
authors: T
authors: Hirata
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Futoshi
authors: F
authors: Higa
authors: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Japan.
authors: Masao
authors: M
authors: Tateyama
authors: Research Division for the Development of Anti-Infective Agents, Institute of Development, Aging and Cancer, Tohoku University, Japan.
authors: Akira
authors: A
authors: Watanabe
authors: Department of Internal Medicine, Shinrakuen Hospital, Japan.
authors: Nobuki
authors: N
authors: Aoki
authors: Department of Clinical Infectious Diseases, School of Medicine, Showa University, Japan.
authors: Yoshihito
authors: Y
authors: Niki
authors: Department of Internal Medicine 2, Oita University Faculty of Medicine, Japan.
authors: Jun-ichi
authors: J
authors: Kadota
authors: Department of Laboratory Medicine, Nagasaki University Hospital, Japan.
authors: Katsunori
authors: K
authors: Yanagihara
authors: Department of Infection Control and Laboratory Diagnostics, Internal Medicine, Tohoku University Graduate School of Medicine, Japan.
authors: Mitsuo
authors: M
authors: Kaku
authors: Department of Infectious Diseases and Infection Control, Jikei University School of Medicine, Japan.
authors: Seiji
authors: S
authors: Hori
authors: Nagasaki University Hospital, Japan.
authors: Shigeru
authors: S
authors: Kohno
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D017714:Community-Acquired Infections / Q000097:blood* / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000097:blood / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D013902:Radiography, Thoracic / Q000379:methods; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae; D014965:X-Rays
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; Chest X-ray infiltration; Community-acquired pneumonia; Streptococcus pneumoniae