title: Modulation of genetic associations with serum urate levels by body-mass-index in humans.
abstract: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Jennifer E
authors: JE
authors: Huffman
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Eva
authors: E
authors: Albrecht
authors: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Alexander
authors: A
authors: Teumer
authors: King's College London, St. Thomas' Hospital Campus, London, United Kingdom.
authors: Massimo
authors: M
authors: Mangino
authors: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
authors: Karen
authors: K
authors: Kapur
authors: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
authors: Toby
authors: T
authors: Johnson
authors: Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland.
authors: Zoltán
authors: Z
authors: Kutalik
authors: Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
authors: Nicola
authors: N
authors: Pirastu
authors: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
authors: Giorgio
authors: G
authors: Pistis
authors: Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Lorna M
authors: LM
authors: Lopez
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia.
authors: Toomas
authors: T
authors: Haller
authors: Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
authors: Perttu
authors: P
authors: Salo
authors: Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors: Anuj
authors: A
authors: Goel
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
authors: Man
authors: M
authors: Li
authors: Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
authors: Toshiko
authors: T
authors: Tanaka
authors: Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Abbas
authors: A
authors: Dehghan
authors: Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
authors: Daniela
authors: D
authors: Ruggiero
authors: Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors: Giovanni
authors: G
authors: Malerba
authors: Icelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
authors: Albert V
authors: AV
authors: Smith
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Ilja M
authors: IM
authors: Nolte
authors: Institute of Population Genetics, National Research Council of Italy, Sassari, Italy.
authors: Laura
authors: L
authors: Portas
authors: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors: Amanda
authors: A
authors: Phipps-Green
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Lora
authors: L
authors: Boteva
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Pau
authors: P
authors: Navarro
authors: Uppsala Clinical Research Center, Uppsala University Hospital, Upsalla, Sweden; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
authors: Asa
authors: A
authors: Johansson
authors: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany.
authors: Andrew A
authors: AA
authors: Hicks
authors: Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia.
authors: Ozren
authors: O
authors: Polasek
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia; Broad Institute, Cambridge, MA, United States of America; Children's Hospital Boston, Boston, MA, United States of America.
authors: Tõnu
authors: T
authors: Esko
authors: Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors: John F
authors: JF
authors: Peden
authors: Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
authors: Sarah E
authors: SE
authors: Harris
authors: Institute of Population Genetics, National Research Council of Italy, Sassari, Italy.
authors: Federico
authors: F
authors: Murgia
authors: Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: Sarah H
authors: SH
authors: Wild
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Albert
authors: A
authors: Tenesa
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
authors: Adrienne
authors: A
authors: Tin
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia.
authors: Evelin
authors: E
authors: Mihailov
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
authors: Anne
authors: A
authors: Grotevendt
authors: Icelandic Heart Association Research Institute, Kopavogur, Iceland.
authors: Gauti K
authors: GK
authors: Gislason
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America.
authors: Josef
authors: J
authors: Coresh
authors: Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
authors: Pio
authors: P
authors: D'Adamo
authors: Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy.
authors: Sheila
authors: S
authors: Ulivi
authors: Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
authors: Peter
authors: P
authors: Vollenweider
authors: Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
authors: Gerard
authors: G
authors: Waeber
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Susan
authors: S
authors: Campbell
authors: Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia.
authors: Ivana
authors: I
authors: Kolcic
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia.
authors: Krista
authors: K
authors: Fisher
authors: Tallinn University of Technology, Department of Biomedical Engineering, Chair of Medical Physics, Tallinn, Estonia; Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia.
authors: Margus
authors: M
authors: Viigimaa
authors: Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
authors: Jeffrey E
authors: JE
authors: Metter
authors: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
authors: Corrado
authors: C
authors: Masciullo
authors: Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors: Elisabetta
authors: E
authors: Trabetti
authors: Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy.
authors: Cristina
authors: C
authors: Bombieri
authors: Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
authors: Rossella
authors: R
authors: Sorice
authors: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Angela
authors: A
authors: Döring
authors: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Eva
authors: E
authors: Reischl
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
authors: Konstantin
authors: K
authors: Strauch
authors: Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Albert
authors: A
authors: Hofman
authors: Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Andre G
authors: AG
authors: Uitterlinden
authors: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Melanie
authors: M
authors: Waldenberger
authors: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany; Klinikum Grosshadern, Munich, Germany.
authors: H-Erich
authors: HE
authors: Wichmann
authors: Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Gail
authors: G
authors: Davies
authors: Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Alan J
authors: AJ
authors: Gow
authors: Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand.
authors: Nicola
authors: N
authors: Dalbeth
authors: Department of Medicine, University of Otago, Christchurch, New Zealand.
authors: Lisa
authors: L
authors: Stamp
authors: Department of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands.
authors: Johannes H
authors: JH
authors: Smit
authors: Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: Mirna
authors: M
authors: Kirin
authors: Laboratory of Genetics, National Institute on Aging (NIA), Baltimore, MD, United States of America.
authors: Ramaiah
authors: R
authors: Nagaraja
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
authors: Matthias
authors: M
authors: Nauck
authors: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Claudia
authors: C
authors: Schurmann
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
authors: Kathrin
authors: K
authors: Budde
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Susan M
authors: SM
authors: Farrington
authors: Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: Evropi
authors: E
authors: Theodoratou
authors: Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland.
authors: Antti
authors: A
authors: Jula
authors: Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland.
authors: Veikko
authors: V
authors: Salomaa
authors: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
authors: Cinzia
authors: C
authors: Sala
authors: University Hospital Regensburg, Regensburg, Germany.
authors: Christian
authors: C
authors: Hengstenberg
authors: Department of Medicine, Nephrology Division, Lausanne University Hospital, Lausanne, Switzerland.
authors: Michel
authors: M
authors: Burnier
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia.
authors: Reedik
authors: R
authors: Mägi
authors: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany.
authors: Norman
authors: N
authors: Klopp
authors: Max Planck Institute of Psychiatry, Munich, Germany.
authors: Stefan
authors: S
authors: Kloiber
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors: Sabine
authors: S
authors: Schipf
authors: Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland.
authors: Samuli
authors: S
authors: Ripatti
authors: Department of Mathematics and Informatics, Università di Cagliari, Cagliari, Italy; Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain.
authors: Stefano
authors: S
authors: Cabras
authors: Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
authors: Nicole
authors: N
authors: Soranzo
authors: Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
authors: Georg
authors: G
authors: Homuth
authors: Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
authors: Teresa
authors: T
authors: Nutile
authors: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
authors: Patricia B
authors: PB
authors: Munroe
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Nicholas
authors: N
authors: Hastie
authors: Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: Harry
authors: H
authors: Campbell
authors: Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia; Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: Igor
authors: I
authors: Rudan
authors: Queen Mary, University of London, London, United Kingdom.
authors: Claudia
authors: C
authors: Cabrera
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Chris
authors: C
authors: Haley
authors: Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors: Oscar H
authors: OH
authors: Franco
authors: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors: Tony R
authors: TR
authors: Merriman
authors: Icelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland.
authors: Vilmundur
authors: V
authors: Gudnason
authors: Institute of Population Genetics, National Research Council of Italy, Sassari, Italy.
authors: Mario
authors: M
authors: Pirastu
authors: Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
authors: Brenda W
authors: BW
authors: Penninx
authors: Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors: Harold
authors: H
authors: Snieder
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia.
authors: Andres
authors: A
authors: Metspalu
authors: Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
authors: Marina
authors: M
authors: Ciullo
authors: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany.
authors: Peter P
authors: PP
authors: Pramstaller
authors: Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
authors: Cornelia M
authors: CM
authors: van Duijn
authors: Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America.
authors: Luigi
authors: L
authors: Ferrucci
authors: Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy.
authors: Giovanni
authors: G
authors: Gambaro
authors: Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom.
authors: Ian J
authors: IJ
authors: Deary
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Malcolm G
authors: MG
authors: Dunlop
authors: Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom.
authors: James F
authors: JF
authors: Wilson
authors: Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy.
authors: Paolo
authors: P
authors: Gasparini
authors: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden.
authors: Ulf
authors: U
authors: Gyllensten
authors: King's College London, St. Thomas' Hospital Campus, London, United Kingdom.
authors: Tim D
authors: TD
authors: Spector
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Alan F
authors: AF
authors: Wright
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Caroline
authors: C
authors: Hayward
authors: on behalf of PROCARDIS; Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
authors: Hugh
authors: H
authors: Watkins
authors: Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland.
authors: Markus
authors: M
authors: Perola
authors: University Institute of Social and Preventive Medicine, Lausanne, Switzerland.
authors: Murielle
authors: M
authors: Bochud
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America.
authors: W H Linda
authors: WH
authors: Kao
authors: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
authors: Mark
authors: M
authors: Caulfield
authors: Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy.
authors: Daniela
authors: D
authors: Toniolo
authors: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors: Henry
authors: H
authors: Völzke
authors: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: Christian
authors: C
authors: Gieger
authors: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Renal Division, Freiburg University Hospital, Freiburg, Germany.
authors: Anna
authors: A
authors: Köttgen
authors: Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom.
authors: Veronique
authors: V
authors: Vitart
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D034961:Antigens, Nuclear / Q000235:genetics; D015992:Body Mass Index; D053339:Edar Receptor / Q000235:genetics; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D005838:Genotype; D006073:Gout / Q000235:genetics / Q000473:pathology; D006801:Humans; D016014:Linear Models; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009765:Obesity / Q000235:genetics / Q000473:pathology; D050177:Overweight / Q000235:genetics; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D034961:Antigens, Nuclear; C506008:EDAR protein, human; D053339:Edar Receptor; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C506808:neuronal nuclear antigen NeuN, human; D014527:Uric Acid; D050862:Oxidoreductases Acting on Sulfur Group Donors; C485767:ERO1B protein, human