title: Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT).
abstract: Sinusoidal obstruction syndrome or veno-occlusive disease (SOS/VOD) is a potentially life-threatening complication of hematopoietic SCT (HSCT). This review aims to highlight, on behalf of the European Society for Blood and Marrow Transplantation, the current knowledge on SOS/VOD pathophysiology, risk factors, diagnosis and treatments. Our perspectives on SOS/VOD are (i) to accurately identify its risk factors; (ii) to define new criteria for its diagnosis; (iii) to search for SOS/VOD biomarkers and (iv) to propose prospective studies evaluating SOS/VOD prevention and treatment in adults and children.
authors: Hematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
authors: M
authors: M
authors: Mohty
authors: Hematology department, Hôpital Saint-Antoine, and Université Pierre & Marie Curie, Paris, France.
authors: F
authors: F
authors: Malard
authors: Inst Portugues Oncologia, Lisboa, Portugal.
authors: M
authors: M
authors: Abecassis
authors: Department of Haematology, University Hospital Zurich, Zurich, Switzerland.
authors: E
authors: E
authors: Aerts
authors: King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, Department of Oncology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
authors: A S
authors: AS
authors: Alaskar
authors: King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors: M
authors: M
authors: Aljurf
authors: Sisli Florence Nightingale Hospital, HSCT Unit, Istanbul, Turkey.
authors: M
authors: M
authors: Arat
authors: Division for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital, Goethe University, Frankfurt/Main, Germany.
authors: P
authors: P
authors: Bader
authors: Department of Hematology, University of Liege, Liege, Belgium.
authors: F
authors: F
authors: Baron
authors: Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
authors: A
authors: A
authors: Bazarbachi
authors: Blood and Marrow Transplantation Program, Hematology Department, Institut Paoli-Calmettes, Marseille, France.
authors: D
authors: D
authors: Blaise
authors: Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.
authors: F
authors: F
authors: Ciceri
authors: Department of Hematology, Oncology, and Stem Cell Transplantation, University of Regensburg, Regensburg, Germany.
authors: S
authors: S
authors: Corbacioglu
authors: Department of Hematology and Immunology, Hospital Robert Debre, Paris 7-Paris Diderot University, Paris, France.
authors: J-H
authors: JH
authors: Dalle
authors: Department of Haematology, Institut Català d'Oncología (ICO) - Hospital Duran i Reynals, Hospitalet de Llobregat, Barcelona, Spain.
authors: R F
authors: RF
authors: Duarte
authors: HSCT division, National Cancer Center Hospital, Tokyo, Japan.
authors: T
authors: T
authors: Fukuda
authors: Hematology department, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France.
authors: A
authors: A
authors: Huynh
authors: Department of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest 3 Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
authors: T
authors: T
authors: Masszi
authors: Hematology Department, Groupement Hospitalier Sud, Hospices Civils de Lyon, Université Claude Bernard Lyon EST, Pierre Bénite, France.
authors: M
authors: M
authors: Michallet
authors: Hematology and Bone Marrow Transplantation, Chaim Sheba Medical center, Tel-Hashomer, Israel.
authors: A
authors: A
authors: Nagler
authors: National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland.
authors: M
authors: M
authors: NiChonghaile
authors: Department of Haematology, King's College Hospital, London, UK.
authors: T
authors: T
authors: Pagluica
authors: Department of Pediatrics, St. Anna Kinderspital, Vienna, Austria.
authors: C
authors: 0000000303698515
authors: C
authors: Peters
authors: LDS Hospital, Salt Lake City, UT, USA.
authors: F B
authors: FB
authors: Petersen
authors: Division of Hematologic Malignancy, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors: P G
authors: PG
authors: Richardson
authors: Comprehensive Cancer Center, Helsinki University Central Hospital, Helsinki, Finland.
authors: T
authors: T
authors: Ruutu
authors: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center and Veterans Affairs Medical Center, Nashville, TN, USA.
authors: B N
authors: BN
authors: Savani
authors: Section of Haematology and Coagulation, Department of Internal Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
authors: E
authors: E
authors: Wallhult
authors: Bone Marrow Transplantation Unit, CHU de Lille, Lille, France.
authors: I
authors: I
authors: Yakoub-Agha
authors: 1] Josep Carreras Leukaemia Research Institute, Barcelona, Spain [2] Haematology Department, Hospital Clinic, Barcelona, Spain [3] Spanish Bone Marrow Donor Program, Josep Carreras Foundation, Barcelona, Spain.
authors: E
authors: E
authors: Carreras
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors; D014652:Vascular Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
chemical_list: D015415:Biomarkers