title: High performances of (18)F-fluorodeoxyglucose PET-CT in cardiac implantable device infections: A study of 40 patients.
abstract: BACKGROUND
  Cardiovascular implantable electronic devices (CIED) infections are life-threatening complications. The diagnosis can be difficult to establish. Our purpose is to evaluate the diagnostic value of (18)F-FDG PET.
  
  
  METHODS
  Forty patients who received work-up for suspected CIED infection were retrospectively included (group 1) and compared with 40 controls (group 2); CIED patients were referred for oncologic PET. PET-CT data were blindly assessed. Interpretation was based on visual analysis of both attenuation-corrected and non-corrected images and a semi-quantitative analysis was performed. The gold standard was bacteriological data of explanted devices or clinical follow-up for at least 1 year.
  
  
  RESULTS
  Infection was present in 18 out of 40 patients of group 1. Sensitivity, specificity, positive predictive value, and negative predictive value of PET-CT were 83%, 95%, 94%, and 88%, respectively. Accuracy was 90%. PET-CT revealed the presence of additional pathological hypermetabolic foci in 28% of cases. PET-CT was negative at implanted devices in all patients of group 2.
  
  
  CONCLUSIONS
  (18)F-FDG PET-CT is helpful in the work-up of suspected CIED infections. It is a potential tool to make the accurate diagnosis of CIED infection and to assess the extent of infection. The promising results in this indication need to be validated in a prospective multicenter study.
authors: CHU de Bordeaux, Service de Médecine Nucléaire, Bordeaux, France, ghoufrane.tlili@chu-bordeaux.fr.
authors: Ghoufrane
authors: G
authors: Tlili
authors: Sana
authors: S
authors: Amraoui
authors: Sana
authors: S
authors: Amroui
authors: Charles
authors: C
authors: Mesguich
authors: Annalisa
authors: A
authors: Rivière
authors: Pierre
authors: P
authors: Bordachar
authors: Elif
authors: E
authors: Hindié
authors: Laurence
authors: L
authors: Bordenave
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017147:Defibrillators, Implantable / Q000009:adverse effects*; D004696:Endocarditis / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D049268:Positron-Emission Tomography / Q000379:methods*; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000209:etiology; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18