title: 2-(1-Hydroxypropyn-2-yl)-1-vinylpyrroles: the first successful Favorsky ethynylation of pyrrolecarbaldehydes.
abstract: 1-Vinylpyrrole-2-carbaldehydes react with acetylene at atmospheric pressure in a NaOH/EtOH/DMSO system at 7-10 °C to afford 2-(1-hydroxypropyn-2-yl)-1-vinylpyrroles in 53-94% yield. Thus, the first base-mediated direct ethynylation of pyrrolecarbaldehydes with free acetylene under modified conditions of the Favorsky reaction has been implemented to pave an expedient route to important biomolecules containing a pyrrole ring.
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: A V
authors: AV
authors: Ivanov
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: V S
authors: VS
authors: Shcherbakova
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: I A
authors: IA
authors: Ushakov
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: L N
authors: LN
authors: Sobenina
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: O V
authors: OV
authors: Petrova
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: A I
authors: AI
authors: Mikhaleva
authors: A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russia, Tel: +7 3952 42-56-31;
authors: B A
authors: BA
authors: Trofimov
keywords: 1-vinylpyrrole-2-carbaldehyde; Favorsky reaction; acetylene; ethynylation