title: Study of CK-MB activity in patients with acute myocardial infarction after percutaneous coronary intervention.
abstract: The research has been carried out in patients of TSMU Cardiovascular Department of A.Aladashvili University Clinic. 105 patients with acute myocardial infarction have been involved in the study, wich undergoing percutaneous coronary intervention (PCI). For several years coronary angioplasty has been proposed to be an effective method, but in spite of its well developed technique, probability of myocardial injury is still high which appears to have no clinical or electrocardiographic manifestations and is diagnosed only by elevation of cardiac marker level. According to our study data after successful PCI elevation of CK-MB mass was observed in 34.4% patients, majority of those patients had STEMI. In II group the age of patients was higher compared to I group. There were more patients with diabetes mellitus (38.8%), dyslipidemia (86.1%) and patients with low left ventricular ejection fraction (50%). Also there were more patients with previous MI and damage of 3 coronary arteries. Hence age, diabetes mellitus, dyslipidemia, left ventricular ejection fraction <40%, number of damaged coronaries might be considered as predictors of CK-MB elevation after successful PCI. Solid elevation of CK-MB after procedure was also associated with increased hospital complications rate, 30-day and 6 months hospitalization rate and 6 months mortality rate. It should be noted that from 36 patients who developed solid (24 h) elevation of CK-MB after PCI CK-MB mass was increased in all cases, while the concentration was elevated only in 16 cases. It proves that CK-MB mass is more significant criteria of myocardial injury.
authors: N M
authors: NM
authors: Emukhvari
authors: E D
authors: ED
authors: Tsetsekhladze
authors: Kh A
authors: KhA
authors: Khijakadze
authors: I O
authors: IO
authors: Mamatsashvili
authors: R G
authors: RG
authors: Napetvaridze
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003331:Coronary Vessels / Q000293:injuries / Q000503:physiopathology; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology / Q000601:surgery; D009206:Myocardium / Q000473:pathology*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011379:Prognosis; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D052279:Creatine Kinase, MB Form