title: Nature-inspired enzymatic cascades to build valuable compounds.
abstract: Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases.
authors: Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13083-970 Campinas, SP, Brazil.
authors: Renata
authors: R
authors: Sigrist
authors: Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13083-970 Campinas, SP, Brazil.
authors: Bruna Zucoloto
authors: BZ
authors: da Costa
authors: Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13083-970 Campinas, SP, Brazil.
authors: Anita Jocelyne
authors: AJ
authors: Marsaioli
authors: Department of Organic Chemistry, Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13083-970 Campinas, SP, Brazil. Electronic address: luciana@iqm.unicamp.br.
authors: Luciana Gonzaga
authors: LG
authors: de Oliveira
mesh_terms: D000470:Alkaloids / Q000378:metabolism; D055162:Biocatalysis; D053898:Biosynthetic Pathways; D001709:Biotechnology; D004798:Enzymes
chemical_list: D000470:Alkaloids; D004798:Enzymes
keywords: Chemo- and multi-enzymatic processes; Cyclases; Hydrolases; Imine reductases; Oxidoreductases; Piperidines and pyrrolidines; Polyethers; Polypeptide alkaloids; Transaminases