title: Clinical translation of controlled protein delivery systems for tissue engineering.
abstract: Strategies that utilize controlled release of drugs and proteins for tissue engineering have enormous potential to regenerate damaged organs and tissues. The multiple advantages of controlled release strategies merit overcoming the significant challenges to translation, including high costs and long, difficult regulatory pathways. This review highlights the potential of controlled release of proteins for tissue engineering and regenerative medicine. We specifically discuss treatment modalities that have reached preclinical and clinical trials, with emphasis on controlled release systems for bone tissue engineering, the most advanced application with several products already in clinic. Possible strategies to address translational and regulatory concerns are also discussed.
authors: Department of Biomedical Engineering, Columbia University, 622 West 168th Street Vanderbilt Clinic 12-234, New York, NY, 10032, USA.
authors: Kara L
authors: KL
authors: Spiller
authors: Gordana
authors: G
authors: Vunjak-Novakovic
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D016503:Drug Delivery Systems; D006801:Humans; D011506:Proteins / Q000008:administration & dosage*; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D003692:Delayed-Action Preparations; D011506:Proteins