title: [Clinical efficacy of preferred use of high-frequency oscillatory ventilation in treatment of neonatal pulmonary hemorrhage].
abstract: OBJECTIVE
  To investigate the clinical efficacy and safety of preferred use of high-frequency oscillatory ventilation (HFOV) in the treatment of neonatal pulmonary hemorrhage.
  
  
  METHODS
  The clinical efficacy of preferred use of HFOV (preferred use group) and rescue use of HFOV after conventional mechanical ventilation proved ineffective (rescue use group) in the treatment of 26 cases of neonatal pulmonary hemorrhage was retrospectively analyzed. The oxygenation index (OI), pulmonary hemorrhage time, hospitalization time, ventilation time, oxygen therapy time, complications, and outcome of the two groups were compared.
  
  
  RESULTS
  Compared with the rescue use group, the preferred use group had significantly lower IO values at 1, 6, 12, 24, 48, and 72 hours after treatment (P<0.05). Compared with the rescue use group, the preferred use group had a significantly lower incidence of ventilator associated pneumonia (VAP) (P<0.05) and a significantly higher cure rate (P<0.05). There were no statistically significant differences in the incidences of pneumothorax, intracranial hemorrhage, and digestive tract hemorrhage between the two groups (P>0.05). Compared with those in the rescue use group, children who survived in the preferred use group had significantly shorter pulmonary hemorrhage time, hospitalization time, ventilation time, and oxygen therapy time (P<0.05).
  
  
  CONCLUSIONS
  Compared with the rescue use of HFOV, preferred use of HFOV can better improve oxygenation function, reduce the incidence of VAP, shorten the course of disease, and increase cure rate while not increasing the incidence of adverse effects.
authors: Department of Neonatology, West China Second Hospital, Sichuan University, Chengdu 610041, China. wujl_2000@sina.com.
authors: Hua
authors: H
authors: Wang
authors: Li-Zhong
authors: LZ
authors: Du
authors: Jun
authors: J
authors: Tang
authors: Jin-Lin
authors: JL
authors: Wu
authors: De-Zhi
authors: DZ
authors: Mu
mesh_terms: D005260:Female; D006470:Hemorrhage / Q000628:therapy*; D006612:High-Frequency Ventilation / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000628:therapy*; D008297:Male; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control; D012189:Retrospective Studies