title: Dendritic cells subsets mediated immune response during Plasmodium berghei ANKA and Plasmodium yoelii infection.
abstract: The roles of dendritic cells (DCs) in mediating immunity against Plasmodium infection have been extensively investigated, but immune response during pathogenesis of malaria is still poorly understood. In the present study, we compared the splenic DCs phenotype and function during P. berghei ANKA (PbA) or P. yoelii (P. yoelii) infection in Swiss mice. We observed that PbA-infected mice developed more myeloid and mature DCs capable of secreting IL-12, while P. yoelii-infected mice had more plasmacytoid and immature DCs secreting higher levels of IL-10. Expression of FoxP3, IL-17, TGF-β and IL-6 were also different between these two infections. Thus, these results suggest that the phenotypic and functional subsets of splenic DCs are key factors for regulating immune responses to PbA and P. yoelii infections.
authors: Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India.
authors: Tarun
authors: T
authors: Keswani
authors: Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India.
authors: Anirban
authors: A
authors: Sengupta
authors: Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India.
authors: Samrat
authors: S
authors: Sarkar
authors: Immunology Laboratory, Department of Zoology, University of Calcutta, 35, Ballygunge Circular Road, Kolkata-700019, West Bengal, India. Electronic address: arindam19@yahoo.com.
authors: Arindam
authors: A
authors: Bhattacharyya
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002452:Cell Count; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology* / Q000469:parasitology*; D051858:Forkhead Transcription Factors / Q000378:metabolism; D007109:Immunity; D016753:Interleukin-10 / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008018:Life Cycle Stages; D008288:Malaria / Q000276:immunology* / Q000469:parasitology*; D008297:Male; D051379:Mice; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology; D010962:Plasmodium berghei / Q000254:growth & development / Q000502:physiology*; D010967:Plasmodium yoelii / Q000254:growth & development / Q000502:physiology*; D013154:Spleen / Q000469:parasitology / Q000473:pathology; D016019:Survival Analysis
chemical_list: D015703:Antigens, CD; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D020381:Interleukin-17; D015850:Interleukin-6; D016753:Interleukin-10; D018664:Interleukin-12
keywords: Myeloid DC; Plasmacytoid DC; Plasmodium berghei ANKA; Plasmodium yoelii; Spleen