title: Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B-cell non-Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG).
abstract: Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B-cell non-Hodgkin lymphoma (B-NHL). We performed a review of 79 abnormal karyotypes in childhood B-NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event-free survival in Burkitt or Burkitt-like lymphoma. The adverse prognosis of MYC/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B-NHL.
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Masahiro
authors: M
authors: Sekimizu
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Tetsuya
authors: T
authors: Mori
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Akira
authors: A
authors: Kikuchi
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Tetsuo
authors: T
authors: Mitsui
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Shosuke
authors: S
authors: Sunami
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Ryoji
authors: R
authors: Kobayashi
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Naoto
authors: N
authors: Fujita
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Hiroko
authors: H
authors: Inada
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Tetsuya
authors: T
authors: Takimoto
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Akiko Moriya
authors: AM
authors: Saito
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Tomoyuki
authors: T
authors: Watanabe
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Junichiro
authors: J
authors: Fujimoto
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Atsuko
authors: A
authors: Nakazawa
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Koichi
authors: K
authors: Ohshima
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Keizo
authors: K
authors: Horibe
authors: Japanese Pediatric Leukemia/Lymphoma Study Group, Lymphoma Committee, Japan.
authors: Masahito
authors: M
authors: Tsurusawa
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D015996:Survival Rate
chemical_list: C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc
keywords: B-NHL03; JPLSG; childhood; cytogenetic abnormality; non-Hodgkin lymphoma