title: Silver sucrose octasulfate nasal applications and wound healing after endoscopic sinus surgery: a prospective, randomized, double-blind, placebo-controlled study.
abstract: OBJECTIVE
  The aim of the present prospective, randomized, double-blind, and placebo-controlled investigation (approved by the Ethical Committee of Padova University Hospital [Italy]) was to assess the effect of a nasal gel containing a combination of silver sucrose octasulfate and potassium sucrose octasulfate (Silsos gel® [SG]) in wound healing after endoscopic sinus surgery (ESS) for chronic rhinosinusitis in terms of: nasal symptoms (SNOT22), endoscopic appearance of the sinonasal mucosa (Lund-Kennedy score), nasal air flow (anterior active rhinomanometry), evidence of mucosal inflammatory processes (nasal cytology and histology), and microbiological growth.
  
  
  METHODS
  Thirty-four patients with chronic rhinosinusitis were randomized on a 1:1 ratio to receive after ESS either SG or placebo (contained only the excipients [carbopol and propylene glycol] in the same concentrations as in SG).
  
  
  CONCLUSIONS
  Judging from the present prospective investigation on patients who underwent ESS for chronic rhinosinusitis, treatment with SG seems to enable a significantly faster improvement in specific symptoms (assessed on the validated SNOT22 scale) than placebo. Patients treated with SG also had a quicker improvement in the endoscopic appearance of their nasal mucosa after ESS than patients treated with placebo. These endoscopic improvements in the SG group were also confirmed at the long-term follow-up, while the same did not apply to the placebo-treated group.
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy. Electronic address: giancarlo.ottaviano@unipd.it.
authors: Giancarlo
authors: G
authors: Ottaviano
authors: Department of Medicine DIMED, Padova University, Padova, Italy.
authors: Stella
authors: S
authors: Blandamura
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Elena
authors: E
authors: Fasanaro
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Niccolo'
authors: N
authors: Favaretto
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Lovato
authors: L
authors: Andrea
authors: Department of Medicine DIMED, Padova University, Padova, Italy.
authors: Luciano
authors: L
authors: Giacomelli
authors: Department of Histology, Microbiology and Medical Biotechnology, Microbiology Section, University of Padova, Padova, Italy.
authors: Andrea
authors: A
authors: Bartolini
authors: Department of Neurosciences DNS, Otolaryngology Section, Treviso Hospital Branch, University of Padova, Treviso, Italy.
authors: Claudia
authors: C
authors: Staffieri
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Rosario
authors: R
authors: Marchese-Ragona
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Gino
authors: G
authors: Marioni
authors: Department of Neurosciences DNS, Otolaryngology Section, Padova University, Padova, Italy.
authors: Alberto
authors: A
authors: Staffieri
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D001706:Biopsy; D002908:Chronic Disease; D004311:Double-Blind Method; D004724:Endoscopy / Q000379:methods*; D015521:Ethmoid Sinusitis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D012220:Rhinitis / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014945:Wound Healing / Q000187:drug effects*; D055815:Young Adult
chemical_list: D000897:Anti-Ulcer Agents; D013395:Sucrose; C053081:sucrose octasulfate