title: Exhaled breath condensate annexin A5 levels in exercise-induced bronchoconstriction in asthma: A preliminary study.
abstract: OBJECTIVE
  The pathogenesis of exercise-induced bronchoconstriction (EIB) in asthma is incompletely understood. The role of exhaled breath condensate (EBC) annexin A5, which is an anti-inflammatory mediator, has not been investigated. The purpose of this study is to evaluate EBC annexin A5 levels in EIB in asthmatic children.
  
  
  METHODS
  Two groups of children were enrolled in this study: asthmatic children with positive (n=11) and negative (n=7) responses to exercise. The levels of pre- and post-exercise EBC annexin A5 were determined with using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  We observed significant higher pre-exercise EBC annexin A5 levels in the challenge test negative children than in the challenge test positive children (p<0.05). No significant difference was observed in the post-exercise EBC annexin A5 levels between the groups (p>0.05). Also, no significant difference was observed between pre- and post-exercise EBC annexin A5 levels within each group (p>0.05). There was an inverse correlation between annexin A5 levels and a reduction in forced expiratory volume at one second percent (FEV1%) (p=0.009, r=-0.598).
  
  
  CONCLUSIONS
  Our preliminary study showed that EBC annexin A5 may have a possible preventive role in EIB in asthma. Annexin A5 and related compounds may provide novel therapeutic approaches to the treatment of EIB in asthma.
authors: Erciyes University School of Medicine, Department of Pediatric Allergy and Asthma, Kayseri, Turkey. Electronic address: tahanfulya@yahoo.com.
authors: F
authors: F
authors: Tahan
authors: Erciyes University School of Medicine, Department of Pediatric Allergy and Asthma, Kayseri, Turkey.
authors: H H
authors: HH
authors: Akar
authors: Erciyes University School of Medicine, Department of Biochemistry, Kayseri, Turkey.
authors: B
authors: B
authors: Saraymen
mesh_terms: D000293:Adolescent; D017304:Annexin A5 / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001250:Asthma, Exercise-Induced / Q000175:diagnosis*; D001944:Breath Tests / Q000379:methods; D016084:Bronchoconstriction; D002648:Child; D002675:Child, Preschool; D045853:Exhalation; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D012129:Respiratory Function Tests
chemical_list: D017304:Annexin A5; D000893:Anti-Inflammatory Agents
keywords: Annexin A5; Asthma exhaled breath condensate; Exercise-induced bronchoconstriction