title: In vitro antiviral activity of germacrone against porcine parvovirus.
abstract: Porcine parvovirus (PPV) infections can lead to significant losses to the swine industry by causing reproductive failure in pigs. Germacrone has been reported to efficiently suppress the replication of influenza virus. In this report, the antiviral activity of germacrone on PPV in swine testis (ST) cells was investigated. Here, we show for the first time that germacrone protects cells from PPV infection and suppresses the synthesis of viral mRNA and protein. Furthermore, we show that germacrone inhibits PPV replication at an early stage in a dose-dependent manner. These findings suggest that germacrone is a potential candidate for anti-PPV therapy.
authors: Guangdong Provincial Key Lab of Agro-animal Genomics and Molecular Breeding, College of Animal Science, National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, Guangdong, 510642, China, scauchenye@163.com.
authors: Ye
authors: Y
authors: Chen
authors: Yunxia
authors: Y
authors: Dong
authors: Yiren
authors: Y
authors: Jiao
authors: Lianjie
authors: L
authors: Hou
authors: Yuzhen
authors: Y
authors: Shi
authors: Ting
authors: T
authors: Gu
authors: Pei
authors: P
authors: Zhou
authors: Zhongyuan
authors: Z
authors: Shi
authors: Lulu
authors: L
authors: Xu
authors: Chong
authors: C
authors: Wang
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D066298:In Vitro Techniques; D010322:Parvoviridae Infections / Q000188:drug therapy / Q000662:veterinary; D028323:Parvovirus, Porcine / Q000187:drug effects* / Q000502:physiology; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D045788:Sesquiterpenes, Germacrane / Q000494:pharmacology*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy; D053585:Virus Attachment / Q000187:drug effects; D053586:Virus Internalization / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D045788:Sesquiterpenes, Germacrane; C048393:germacrone