title: Quantitative assessment of photostability and photostabilisation of Fluvoxamine and its design for actinometry.
abstract: Despite the numerous concerns that have been raised in relation to considering 0(th), 1(st) and 2(nd)-order kinetic treatments for photodegradation characterisation and assessment of drugs, they still are employed, as they are the only tools available for these types of studies. The recently developed Φ-order kinetic models have opened new perspectives in the treatment of photoreaction kinetics and stand as the best known alternative to the classical approach. The Φ-order kinetics have been applied here to Fluvoxamine (Fluvo) with the aim of setting out a detailed and comprehensive procedure capable of rationalising photodegradation/photostability of drugs and proposing a platform for photosafety studies. Our results prove that quantum yields of drugs (0.0016 < Φ(λirr)(Fluvo) < 0.43) should a priori be considered wavelength-dependent; their photostabilisation (up to 75% for Fluvo) by means of absorption competitors can explicitly be related to a decrease of the photokinetic factor, and photoreversible drugs can be developed into efficient actinometers (as Fluvoxamine in the 260-290 nm range). A pseudo-rate-constant factor was proposed as a descriptive parameter, circumventing the limitations of overall rate-constants and allowing a comparison between kinetic data of drugs obtained under different conditions.
authors: Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK. mmaafi@dmu.ac.uk.
authors: Mounir
authors: M
authors: Maafi
authors: Wassila
authors: W
authors: Maafi
mesh_terms: D002851:Chromatography, High Pressure Liquid; D016666:Fluvoxamine / Q000737:chemistry* / Q000528:radiation effects*; D007536:Isomerism; D007700:Kinetics; D008027:Light; D016014:Linear Models; D008956:Models, Chemical; D015394:Molecular Structure; D055668:Photochemical Processes; D012996:Solutions; D013645:Tartrazine / Q000737:chemistry / Q000528:radiation effects; D014867:Water / Q000737:chemistry
chemical_list: D012996:Solutions; D014867:Water; D013645:Tartrazine; D016666:Fluvoxamine