title: Probing extracellular acidity of live cells in real time for cancer detection and monitoring anti-cancer drug activity.
abstract: We report a novel electrochemical strategy to probe the microenvironment of live cells in real time in terms of its extracellular pH. This approach allowed highly sensitive detection of cancer cells down to five cells. Utility of the sensor for evaluating the efficacy of glycolysis inhibiting anti-cancer drugs is also demonstrated.
authors: Chemistry Division, Mumbai 400085, India.
authors: Bhawana
authors: B
authors: Thakur
authors: S
authors: S
authors: Jayakumar
authors: Shilpa N
authors: SN
authors: Sawant
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002469:Cell Separation; D002470:Cell Survival; D004354:Drug Screening Assays, Antitumor; D004563:Electrochemistry / Q000379:methods*; D005110:Extracellular Space / Q000737:chemistry* / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013997:Time Factors; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents