title: Chorionic bump in pregnant patients and associated live birth rate: a systematic review and meta-analysis.
abstract: OBJECTIVE
  A chorionic bump on first-trimester sonography has been considered a risk factor for nonviability in pregnant patients with this rare finding, although the strength of this association has recently been questioned. We performed a systematic review and meta-analysis to summarize the association between a chorionic bump and nonviability.
  
  
  METHODS
  A comprehensive literature search was performed. We included all studies except case reports. A meta-analysis was performed using a random-effects model.
  
  
  RESULTS
  After screening 5 studies, 2 studies with a total of 67 patients met inclusion criteria. These were combined with a study (n = 52) from our institution. Overall, the live birth rate was 62% (74 of 119). Fifty-one chorionic bump pregnancies were otherwise normal (ie, pregnancies in which a gestational sac, a yolk sac, and an embryo with a heartbeat was seen at some point), and in this subset, the live birth rate was 83% (42 of 51). There was no significant relationship found between vaginal bleeding and live birth (P = .857); there was no significant difference in bump volume between live birth and no live birth (P = .198); and for the subset analysis of pooled odds ratios for the relationship between live birth and history of infertility, there was no significant relationship found (P = .186).
  
  
  CONCLUSIONS
  A chorionic bump remains a risk factor for nonviability in pregnancy; however, if the pregnancy is otherwise normal, then most result in live birth.
authors: New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York USA. ela9033@med.cornell.edu.
authors: Elizabeth Kagan
authors: EK
authors: Arleo
authors: New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York USA.
authors: Allison
authors: A
authors: Dunning
authors: New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York USA.
authors: Robert N
authors: RN
authors: Troiano
mesh_terms: D001723:Birth Rate; D002823:Chorion / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth; D011247:Pregnancy; D012307:Risk Factors; D016216:Ultrasonography, Prenatal
keywords: chorionic bump; live birth rate; meta-analysis; obstetric ultrasound