title: Synthesis and antiproliferative evaluation of some novel B-nor-D-homosteroids.
abstract: Using 3β-hydroxy-5-androsten-17-one as a starting material, a series of novel nitrogen-containing B-nor-D-homosteroids were designed and synthesized by the oximation, Beckman rearrangement, ozonation, cyclization and condensation reaction. The structures of all new compounds were determined by analysis of their NMR, MS and IR spectra. The antiproliferative activity of compounds was evaluated against HT-29 (colonic carcinoma), HeLa (human cervical carcinoma) and Bel 7404 (human liver carcinoma) cells.
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Jianguo
authors: J
authors: Cui
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Qifu
authors: Q
authors: Lin
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Chunfang
authors: C
authors: Gan
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Junyan
authors: J
authors: Zhan
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Wei
authors: W
authors: Su
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Dandan
authors: D
authors: Zhao
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China.
authors: Binbin
authors: B
authors: Qi
authors: College of Chemistry and Materials Science, Guangxi Teachers Education University, Nanning 530001, China. Electronic address: huangyanmin828@163.com.
authors: Yanmin
authors: Y
authors: Huang
mesh_terms: D000734:Androstenediols / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans
chemical_list: C003561:3,15-dihydroxy-5-androst-en-17-one; D000734:Androstenediols; D000970:Antineoplastic Agents
keywords: 3β-Hydroxy-5-androsten-17-one; Antiproliferative activity; B-nor-D-homosteroids; Dehydroepiandrosterone