title: Bone marrow granuloma in typhoid Fever: a morphological approach and literature review.
abstract: Typhoid fever is one of the few bacterial infections in humans where bone marrow evaluation is routinely recommended. However, the morphological aspect of typhoid fever in bone marrow has been rarely described in the literature. We describe a 25-year-old male patient who presented with prolonged fever suspected to be of tubercular etiology. Bone marrow examination showed well-formed histiocytic and epithelioid granulomas and erythrophagocytosis; and the bone marrow aspirate culture grew Salmonella typhi A. In view of potential clinical implications, typhoid fever should be considered as a differential diagnosis to tuberculosis in the evaluation of prolonged fever; especially in high prevalent areas. We suggest that erythrophagocytosis may serve as a morphological marker in typhoid granulomas in the bone marrow; and bone marrow culture should be submitted in every suspected case for appropriate patient management.
authors: Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Kavitha
authors: K
authors: Muniraj
authors: Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Somanath
authors: S
authors: Padhi
authors: Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Manjiri
authors: M
authors: Phansalkar
authors: Department of General Medicine, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Periyasami
authors: P
authors: Sivakumar
authors: Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Renu G'Boy
authors: RG
authors: Varghese
authors: Department of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry 605014, India.
authors: Reba
authors: R
authors: Kanungo