title: Increased plasma monocyte chemoattractant protein-1 levels in patients with isolated low high-density lipoprotein cholesterol.
abstract: BACKGROUND
  High-density lipoprotein cholesterol (HDL-C) inhibits inflammation associated with the development of atherosclerotic plaques. Monocyte chemoattractant protein-1 (MCP-1) contributes to the pathogenesis of atherosclerosis. The aim of this study was to evaluate the relationship between plasma MCP-1 levels and low HDL-C levels in patients without cardiovascular disease (CVD).
  
  
  METHODS
  This study included 55 patients with low HDL-C (≤ 35 mg/dL) and 33 age- and sex-matched control subjects with normal HDL-C (˃ 35 mg/dL). In addition to MCP-1 levels, laboratory parameters associated with inflammation such as neutrophil-lymphocyte ratio (NLR), uric acid and high sensitivity C-reactive protein (hs-CRP) were also evaluated.
  
  
  RESULTS
  HDL-C levels was significantly lower in study group compared to that of the control group (p < 0.001). MCP-1 were prominently higher in the low HDL-C group compared with those of the control group (p < 0.01). NLR, uric acid and hs-CRP levels were also higher in patients with low HDL-C than controls.
  
  
  CONCLUSIONS
  These findings suggest that elevated plasma MCP-1 levels and inflammation status might be associated with the increased cardiovascular risk in patients with low HDL-C.
authors: Department of Cardiology, Isparta State Hospital , Isparta.
authors: Mustafa
authors: M
authors: Karabacak
authors: Fatih
authors: F
authors: Kahraman
authors: Mehmet
authors: M
authors: Sert
authors: Erdal
authors: E
authors: Celik
authors: Mehmet Koray
authors: MK
authors: Adali
authors: Ercan
authors: E
authors: Varol
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism; D018932:Chemokine CCL2 / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D008076:Cholesterol, HDL; D014527:Uric Acid; D002097:C-Reactive Protein
keywords: High-density lipoprotein cholesterol; inflammation; monocyte chemoattractant protein-1; uric acid