title: Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.
abstract: A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.
authors: Centre for Biomolecular Sciences, University Park Nottingham , Nottingham NG7 2RD, U.K.
authors: Carolin
authors: C
authors: Schwehm
authors: Hitgen Ltd. , F7-10, Building B3, Tianfu Life Science Park, 88 South Kayuan Road, Chengdu, Sichuan 610041, China.
authors: Jin
authors: J
authors: Li
authors: Hitgen Ltd. , F7-10, Building B3, Tianfu Life Science Park, 88 South Kayuan Road, Chengdu, Sichuan 610041, China.
authors: Hongmei
authors: H
authors: Song
authors: Hitgen Ltd. , F7-10, Building B3, Tianfu Life Science Park, 88 South Kayuan Road, Chengdu, Sichuan 610041, China.
authors: Xiao
authors: X
authors: Hu
authors: Centre for Biomolecular Sciences, University Park Nottingham , Nottingham NG7 2RD, U.K.
authors: Barrie
authors: B
authors: Kellam
authors: Centre for Biomolecular Sciences, University Park Nottingham , Nottingham NG7 2RD, U.K.
authors: Michael J
authors: MJ
authors: Stocks
keywords: 1,2,4-triazole; Diabetes; crystal structure; dipeptyl peptidase VI (DPP-4) inhibitor; scaffold