title: Robustness of steady state recycling chromatography with an integrated solvent removal unit.
abstract: The robustness of a hybrid separation process where the performance of mixed-recycle steady state recycling chromatography is enhanced by integrating it with a solvent removal unit is analysed theoretically and by means of numerical simulations. The equilibrium theory of chromatography is applied to derive equations for boundaries of feasible operating parameters in such a hybrid process. Visualization of the feasible operating parameter ranges helps in analysing the influence of various physical and process parameters of robustness of an operating point. It is observed that process robustness can be improved by adjusting the solvent removal capacity or the cut times. When the solvent removal capacity increases, the region of feasible cut times becomes narrower due to increased non-linearity of the system. This makes it more difficult to maintain robust operation.
authors: Lappeenranta University of Technology, Skinnarilankatu 34, FI-53850 Lappeenranta, Finland.
authors: Jani
authors: J
authors: Siitonen
authors: Lappeenranta University of Technology, Skinnarilankatu 34, FI-53850 Lappeenranta, Finland.
authors: Mika
authors: M
authors: Mänttäri
authors: Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstrasse 1, DE-39106 Magdeburg, Germany.
authors: Andreas
authors: A
authors: Seidel-Morgenstern
authors: Lappeenranta University of Technology, Skinnarilankatu 34, FI-53850 Lappeenranta, Finland. Electronic address: Tuomo.Sainio@lut.fi.
authors: Tuomo
authors: T
authors: Sainio
mesh_terms: D002845:Chromatography / Q000379:methods*; D008962:Models, Theoretical; D011804:Quinolines / Q000737:chemistry; D012997:Solvents / Q000302:isolation & purification*; D013237:Stereoisomerism; D013829:Thiadiazines / Q000737:chemistry
chemical_list: C503930:EMD 53986; D011804:Quinolines; D012997:Solvents; D013829:Thiadiazines
keywords: Equilibrium theory; Robustness; Solvent removal; Steady state recycling; Unified design