title: A prospective study comparing ultrapulse CO2 laser and trichloroacetic acid in treatment of Xanthelasma palpebrarum.
abstract: BACKGROUND
  Xanthelasma Palpebrarum is a type of xanthoma which presents as cosmetic concern.
  
  
  OBJECTIVE
  To compare the efficacy of 30% TCA and UpCO2 laser in XP.
  
  
  METHODS
  Fifty patients with XP were categorized clinically into three groups. Patients in each group were alternately allocated to 30% TCA (Group A) and laser (Group B). TCA was applied weekly (maximum: 12 sessions), and laser sessions were given monthly (maximum: three sessions). The primary outcome measures were total patients cured, the number of sessions, and mean VAS at the end of treatment. The secondary outcome measures were total duration of treatment, side effects, and recurrence in follow-up (6 months) (P < 0.05 significant).
  
  
  RESULTS
  In Group A, 14 of 25 and in Group B, 25 of 25 patients achieved complete cure (P < 0.05). The mean VAS was lower for Group A (patient: 4.56 vs. 5.36; physician: 4.64 vs. 5.44) [P < 0.05] with significant difference only for group III patients. Mean number of sessions was less with laser group (1.56 vs. 9.74), except in group I. There was no significant difference in pigmentary changes and recurrence.
  
  
  CONCLUSIONS
  For clinically mild lesions, both TCA and laser are good options, but laser is a better option for severe lesions. Recurrence is a concern with both modalities.
authors: Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, India.
authors: Khushbu
authors: K
authors: Goel
authors: Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, India.
authors: Kabir
authors: K
authors: Sardana
authors: Department of Dermatology, Venereology and Leprology, Maulana Azad Medical College & Associated Lok Nayak Hospital, New Delhi, India.
authors: Vijay Kumar
authors: VK
authors: Garg
mesh_terms: D000328:Adult; D000368:Aged; D005143:Eyelids; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology; D054020:Lasers, Gas / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D012008:Recurrence; D012871:Skin Diseases / Q000532:radiotherapy*; D014238:Trichloroacetic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D014973:Xanthomatosis / Q000532:radiotherapy*
chemical_list: D014238:Trichloroacetic Acid
keywords: Xanthelasma palpebrarum; laser treatment; trichloroacetic acid