title: Hydrogen Therapy Reduces Oxidative Stress-associated Risks Following Acute and Chronic Exposure to High-altitude Environment.
abstract: Low pressure, low oxygen concentration, and intense ultraviolet (UV) radiation in high-altitude environments, can cause oxidative stress which can trigger mountain sickness. A recent study demonstrated that hydrogen gas with a good permeability in biological membranes can treat various disorders by exerting its selective anti-oxidation and anti-inflammatory effects, indicating that hydrogen therapy plays a role in scavenging free radicals and in balancing oxidation and anti-oxidation systems of cells. Therefore, we hypothesize that inhaling low-dose hydrogen or drinking hydrogen-saturated water is a novel and simple method to prevent and treat oxidative stress injury caused by low pressure, low oxygen concentration and intense UV radiation in plateaus, thus reducing the risk of mountain sickness.
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Qing Hai
authors: QH
authors: Shi
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Wei
authors: W
authors: Wei
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Ji Hua
authors: JH
authors: Ran
authors: Central South University Xiangya Medical School, Changsha 410078, Hunan, China.
authors: Si Yuan
authors: SY
authors: Wang
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Zheng Xiang
authors: ZX
authors: Liu
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Di
authors: D
authors: Ge
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Ping
authors: P
authors: Chen
authors: Clinical Laboratory and Diagnostic Center, Urumqi General Hospital of Chinese PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China.
authors: Jian Feng
authors: JF
authors: Fu
mesh_terms: D000531:Altitude; D004781:Environmental Exposure; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D006859:Hydrogen / Q000627:therapeutic use*; D018384:Oxidative Stress; D010100:Oxygen / Q000032:analysis; D014466:Ultraviolet Rays
chemical_list: D016166:Free Radical Scavengers; D006859:Hydrogen; D010100:Oxygen