title: The possible role of glutathione-S-transferase activity in diabetic nephropathy.
abstract: The most common cause of end stage renal disease is diabetic nephropathy. An early diagnosis may allow an intervention to slow down disease progression. Recently, it has been hypothesized that glutathione-S-transferase (GST) activity may be a marker of severity of chronic kidney disease. In particular, a lower GST activity is present in healthy subjects compared to patients with nephropathy. In the present review we illustrate the scientific evidence underlying the possible role of GST activity in the development of diabetic nephropathy and we analyze its usefulness as a possible early biomarker of this diabetic complication.
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: M
authors: M
authors: Tesauro
authors: Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy steven.nistico@gmail.com.
authors: S
authors: S
authors: Nisticò
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: A
authors: A
authors: Noce
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: A
authors: A
authors: Tarantino
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: G
authors: G
authors: Marrone
authors: Center of Integrated Research, Campus Bio-Medico University of Rome, Rome, Italy.
authors: A
authors: A
authors: Costa
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: V
authors: V
authors: Rovella
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: G
authors: G
authors: Di Cola
authors: MedStar Cardiovascular Research Network Washington, DC, USA.
authors: U
authors: U
authors: Campia
authors: Endocrinology Unit, University of Rome "Tor Vergata", Rome, Italy.
authors: D
authors: D
authors: Lauro
authors: Internal Medicine, Catholic University, Rome, Italy.
authors: C
authors: C
authors: Cardillo
authors: Department of Systems Medicine, Division of Hypertension and Nephrology, University of Rome "Tor Vergata", Rome, Italy.
authors: N
authors: N
authors: Di Daniele
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D048909:Diabetes Complications / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005982:Glutathione Transferase
keywords: biomarkers; diabetic nephropathy; glutathione-S-transferase; oxidative stress