title: Intertoe Squamous Cell Carcinoma Developed in a Patient with Rheumatoid Arthritis under Etanercept Therapy.
abstract: The use of tumor necrosis factor-α (TNF-α) inhibitors in the treatment of various inflammatory conditions has altered the field of medical therapeutics. Squamous cell carcinoma is the second most common cancer of the skin, usually affecting sun-exposed areas of the body. We present here the case of a 75-year-old woman with rheumatoid arthritis, who developed an intertoe squamous cell carcinoma (SCC) of the right foot. According to her history, she received etanercept and methotrexate for 5 years for rheumatoid arthritis. The rare localization of this cancer could suggest a possible linkage of the malignancy to the chronic intake of anti-TNF-α treatment. This is the first reported case of an interdigital SCC developed under the use of an anti-TNF-α agent.
authors: Department of Dermatology, Veterans Administration Hospital (NIMTS), Monis Petraki 10-12, 11521 Athens, Greece.
authors: Efstathios
authors: 0000-0001-8806-281X
authors: E
authors: Rallis
authors: Department of Rheumatology, Veterans Administration Hospital (NIMTS), Monis Petraki 10-12, 11521 Athens, Greece.
authors: Vasiliki-Kalliopi
authors: VK
authors: Bournia
authors: Private Practice, Tripolis, Greece.
authors: Constantinos
authors: C
authors: Verros
authors: Department of Rheumatology, Veterans Administration Hospital (NIMTS), Monis Petraki 10-12, 11521 Athens, Greece.
authors: Alexios
authors: 0000-0001-7107-1664
authors: A
authors: Iliopoulos