title: Human Fitting Studies of Cleveland Clinic Continuous-Flow Total Artificial Heart.
abstract: Implantation of mechanical circulatory support devices is challenging, especially in patients with a small chest cavity. We evaluated how well the Cleveland Clinic continuous-flow total artificial heart (CFTAH) fit the anatomy of patients about to receive a heart transplant. A mock pump model of the CFTAH was rapid-prototyped using biocompatible materials. The model was brought to the operative table, and the direction, length, and angulation of the inflow/outflow ports and outflow conduits were evaluated after the recipient's ventricles had been resected. Thoracic cavity measurements were based on preoperative computed tomographic data. The CFTAH fit well in all five patients (height, 170 ± 9 cm; weight, 75 ± 24 kg). Body surface area was 1.9 ± 0.3 m (range, 1.6-2.1 m). The required inflow and outflow port orientation of both the left and right housings appeared consistent with the current version of the CFTAH implanted in calves. The left outflow conduit remained straight, but the right outflow direction necessitated a 73 ± 22 degree angulation to prevent potential kinking when crossing over the connected left outflow. These data support the fact that our design achieves the proper anatomical relationship of the CFTAH to a patient's native vessels.
authors: From the *Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; †Department of Thoracic and Cardiovascular Surgery, Kaufman Center for Heart Failure, Cardiac Transplantation and Mechanical Circulatory Support, Miller Family Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio; and ‡Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
authors: Jamshid H
authors: JH
authors: Karimov
authors: Robert J
authors: RJ
authors: Steffen
authors: Nicole
authors: N
authors: Byram
authors: Gengo
authors: G
authors: Sunagawa
authors: David
authors: D
authors: Horvath
authors: Vincent
authors: V
authors: Cruz
authors: Leonard A R
authors: LA
authors: Golding
authors: Kiyotaka
authors: K
authors: Fukamachi
authors: Nader
authors: N
authors: Moazami
mesh_terms: D049628:Body Size; D004867:Equipment Design; D005260:Female; D006333:Heart Failure / Q000601:surgery; D006353:Heart-Assist Devices; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D035423:Thoracic Cavity / Q000033:anatomy & histology*