title: Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a devastating age-related neurodegenerative disease with no specific treatment at present. The APPsw/Tg2576 mice exhibit age-related deterioration in memory and learning as well as amyloid-beta (Aβ) accumulation, and this mouse strain is considered an effective model for studying the mechanism of accelerated brain aging and senescence. The present study was aimed to investigate the beneficial effects of dietary supplements pomegranate, figs, or the dates on suppressing inflammatory cytokines in APPsw/Tg2576 mice. Changes in the plasma cytokines and Aβ, ATP, and inflammatory cytokines were investigated in the brain of transgenic mice. Significantly enhanced levels of inflammatory cytokines IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, TNF-α and Eotaxin activity were decreased by administration of the diet supplements containing pomegranates, figs, or dates. In addition, putative delays in the formation of senile plaques, as indicated by a decreasing tendency of brain Aβ1-40 and Aβ1-42 contents, were observed. Thus, novel results mediated by reducing inflammatory cytokines during aging may represent one mechanism by which these supplements exert their beneficial effects against neurodegenerative diseases such as AD.
authors: Dept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Muscat, Oman; Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman; Neuropharmacology group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, Sydney, NSW, Australia.
authors: Musthafa Mohamed
authors: MM
authors: Essa
authors: Dept of Food Science and Nutrition, College of Agriculture and Marine Sciences, Sultan Qaboos University, Muscat, Oman; Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman.
authors: Selvaraju
authors: S
authors: Subash
authors: Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States of America.
authors: Mohammed
authors: M
authors: Akbar
authors: Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman; College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
authors: Samir
authors: S
authors: Al-Adawi
authors: Neuropharmacology group, MND and Neurodegenerative Diseases Research Centre, Macquarie University, Sydney, NSW, Australia.
authors: Gilles J
authors: GJ
authors: Guillemin
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis; D000818:Animals; D001921:Brain / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D030681:Ficus / Q000737:chemistry* / Q000378:metabolism; D005638:Fruit / Q000737:chemistry / Q000378:metabolism; D029561:Lythraceae / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D065749:Phoeniceae / Q000737:chemistry* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D016207:Cytokines; D000255:Adenosine Triphosphate