title: Clinical approach to the patient with AKI and sepsis.
abstract: Sepsis and acute kidney injury (AKI) frequently are combined in critical care patients. They both are associated independently with increased mortality and morbidity. AKI may precede, coincide with, or follow a sepsis diagnosis. Risk factors for sepsis followed by AKI differ from those associated with AKI preceding or coinciding with sepsis, and the pathophysiologic mechanisms may be different. In this article, we review the available clinical, laboratory, and imaging tools available for the recognition of septic AKI. Early identification of high-risk patients and targeted preventive and therapeutic measures are key to reducing the mortality and morbidity of the complex syndrome of septic AKI.
authors: Division of Nephrology, Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
authors: Mélanie
authors: M
authors: Godin
authors: School of Medicine and Medical Science, Health Sciences Centre, University College Dublin, Dublin, Ireland.
authors: Patrick
authors: P
authors: Murray
authors: Division of Nephrology, School of Medicine, University of California, San Diego, CA. Electronic address: rmehta@ucsd.edu.
authors: Ravindra L
authors: RL
authors: Mehta
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019468:Disease Management; D042241:Early Diagnosis; D061345:Early Medical Intervention; D005440:Fluid Therapy; D006801:Humans; D056747:Immunomodulation; D017582:Renal Replacement Therapy; D018805:Sepsis / Q000150:complications / Q000628:therapy*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014662:Vasoconstrictor Agents
keywords: AKI; management; renal injury; sepsis