title: Diagnosis, PET/CT imaging, and treatment of extranodal non-Hodgkin lymphoma in keratinized gingiva: a case report.
abstract: A 58-year-old patient who smoked and had uncontrolled type 2 diabetes mellitus was referred to our clinic. The patient had a suspicious asymptomatic lesion that was diagnosed as B-cell non-Hodgkin lymphoma (NHL). Immunohistochemistry revealed intense and diffuse expression of CD20, CD10, BCL-6, and Ki-67. A positron emission tomography/computed tomography (PET/CT) scan showed focal pathological uptake of F-18-fluorodeoxyglucose only in the subcutaneous tissue anterior to the left maxillary sinus. After lesion excision and five courses of chemotherapy, PET/CT scans demonstrated complete resolution of the lesion. Smoking, uncontrolled diabetes mellitus, and periodontal disease might be predisposing factors for oral NHL.
authors: Department of Periodontology, Faculty of Dentistry, Sifa University.
authors: Cüneyt A
authors: CA
authors: Aral
authors: Osman S
authors: OS
authors: Ağlarcı
authors: Hasan H
authors: HH
authors: Yılmaz
authors: Funda
authors: F
authors: Taşlı
authors: Serap
authors: S
authors: Karaarslan
authors: Filiz
authors: F
authors: Hatipoğlu
authors: Mustafa S
authors: MS
authors: Sanal
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2; D019788:Fluorodeoxyglucose F18; D005887:Gingival Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D019647:Oral Surgical Procedures; D000072078:Positron Emission Tomography Computed Tomography; D011862:Radiography, Panoramic; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007633:Keratins