title: Predicting clinical response in people at ultra-high risk of psychosis: a systematic and quantitative review.
abstract: People at ultra-high risk (UHR) of psychosis have ∼30% chance of developing the illness within two years. A range of pharmacological and psychosocial interventions are now available but there is great individual variation in clinical response. Here we examine the evidence for clinically applicable predictors of clinical response in people at UHR of psychosis. We report that currently there are no reliable predictive markers that can be used to optimise treatment. We argue that there is an urgent need for a better understanding of why some people at UHR of psychosis benefit from a certain treatment whereas others do not. This information will help clinicians make more-effective treatment decisions, and improve long-term clinical outcomes in this population.
authors: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, UK. Electronic address: a.mechelli@kcl.ac.uk.
authors: Andrea
authors: A
authors: Mechelli
authors: Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, UK; Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028 Lisboa, Portugal.
authors: Diana
authors: D
authors: Prata
authors: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, UK.
authors: Charles
authors: C
authors: Kefford
authors: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, 16 De Crespigny Park, SE5 8AF, UK.
authors: Shitij
authors: S
authors: Kapur
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003661:Decision Support Techniques; D006801:Humans; D018579:Patient Selection; D011237:Predictive Value of Tests; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents