title: A response strategy predicts acquisition of schedule-induced polydipsia in rats.
abstract: Schedule-induced polydipsia (SIP) is excessive, non-regulatory drinking. We aimed to identify phenotypic learning traits representative of neural circuitry that underlies SIP and hypothesized that rats that are response-learners will be more susceptible in developing compulsive water drinking. Using the Y-maze, the rats were characterized as either place- or response-learners. They were exposed to the SIP protocol for a period of 21days. Subsequent histological staining for FosB/ΔFosB examined neuronal activation associated with SIP in several brain regions. The rats with a preference for a response-learning strategy were more likely to develop SIP than the rats using a place-learning strategy. Furthermore amphetamine sensitization, observed to increase SIP, also shifted learning strategy to a response-learning strategy. No differences were observed in FosB/ΔFosB expression between SIP and non-SIP rats in the dorsolateral striatum (DLS) and CA1 region of the hippocampus. However, SIP rats had greater FosB/ΔFosB expression in prefrontal cortex regions. The rats that develop SIP have a preference for response-learning strategies and increased neuronal activation in frontal cortical regions associated with habit formation and compulsion.
authors: Centre for Neuroscience Studies, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada.
authors: James Gardner
authors: JG
authors: Gregory
authors: Dept. Biomedical and Molecular Sciences, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada. Electronic address: erhawken@gmail.com.
authors: Emily R
authors: ER
authors: Hawken
authors: Dept. Neuroscience, University of Pittsburgh, 4200 Fifth Avenue, Pittsburgh, PA 15260, USA.
authors: Tomek J
authors: TJ
authors: Banasikowski
authors: Centre for Neuroscience Studies, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada; Dept. Biomedical and Molecular Sciences, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada; Dept. Psychiatry, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada.
authors: Eric C
authors: EC
authors: Dumont
authors: Centre for Neuroscience Studies, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada; Dept. Psychology, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada; Dept. Psychiatry, Queen's University, 99 University Ave, Kingston, ON K7L 3N6, Canada.
authors: Richard J
authors: RJ
authors: Beninger
mesh_terms: D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D059606:Polydipsia / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D011237:Predictive Value of Tests; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; C483820:Fosb protein, rat; D016760:Proto-Oncogene Proteins c-fos; D000661:Amphetamine
keywords: Amphetamine; Compulsivity; Immediate early gene; Impulsivity; Learning; Memory