title: Mechanical and physicochemical characterization along with biological interactions of a new Ti25Nb21Hf alloy for bone tissue engineering.
abstract: Nowadays, one of the main challenges in metal implants for bone substitution is the achievement of an elastic modulus close to that of human cortical bone as well as to provide an adequate interaction with the surrounding tissue avoiding in vivo foreign body reaction. From this perspective, a new Ti-based alloy has been developed with Nb and Hf as alloying elements which are known as non-toxic and with good corrosion properties. The microstructure, mechanical behaviour and the physicochemical properties of this novel titanium alloy have been studied. Relationship of surface chemistry and surface electric charge with protein adsorption and cell adhesion has been evaluated due to its role for understanding the mechanism of biological interactions with tissues. The Ti25Nb21Hf alloy presented a lower elastic modulus than commercial alloys with a superior ultimate strength and yield strength than CP-Ti and very close to Ti6Al4V. It also exhibited good corrosion resistance. Furthermore, the results revealed that it had no cytotoxic effect on rat mesenchymal stem cells and allowed protein adsorption and cell adhesion. The experimental results make this alloy a promising material for bone substitution or for biomedical devices.
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Barcelona, Spain.
authors: C
authors: C
authors: Herranz-Diez
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Barcelona, Spain Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain Centre for Research in NanoEngineering (CRNE) - UPC, Barcelona, Spain.
authors: F J
authors: FJ
authors: Gil
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Barcelona, Spain Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain Centre for Research in NanoEngineering (CRNE) - UPC, Barcelona, Spain.
authors: J
authors: J
authors: Guillem-Marti
authors: Biomaterials, Biomechanics and Tissue Engineering Group, Department of Materials Science and Metallurgy, Technical University of Catalonia (UPC), Barcelona, Spain Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain Centre for Research in NanoEngineering (CRNE) - UPC, Barcelona, Spain jose.maria.manero@upc.edu.
authors: J M
authors: JM
authors: Manero
mesh_terms: D000327:Adsorption; D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials; D001846:Bone Development; D002448:Cell Adhesion; D002478:Cells, Cultured; D005353:Fibronectins / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology; D051381:Rats; D011917:Rats, Inbred Lew; D013499:Surface Properties; D023822:Tissue Engineering; D017155:Wettability; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D005353:Fibronectins; C000606704:Ti25Nb21Hf alloy
keywords: Titanium-based alloy; cell adhesion; contact angle; electrochemical behaviour; in vitro cell culture; protein adsorption