title: Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response?
abstract: Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its extra-skeletal roles. It has an important influence on the body's immune system and modulates both innate and adaptive immunity and regulates the inflammatory cascade. In this review our aim was to describe how VitD might influence immune responsiveness and its potential modulating role in vaccine immunogenicity. In the first instance, we consider the literature that may provide molecular and genetic support to the idea that VitD status may be related to innate and/or adaptive immune response with a particular focus on vaccine immunogenicity and then discuss observational studies and controlled trials of VitD supplementation conducted in humans. Finally, we conclude with some knowledge gaps surrounding VitD and vaccine response, and that it is still premature to recommend "booster" of VitD at vaccination time to enhance vaccine response.
authors: Geriatric medicine and Geriatric rehabilitation division, Department of medicine, University Hospital of Lausanne (CHUV), CH-1011 Lausanne, Switzerland. pierre-olivier.lang@chuv.ch.|Health and Wellbeing academy, Anglia Ruskin University, CM1 1SQ Cambridge, UK. pierre-olivier.lang@chuv.ch.
authors: Pierre Olivier
authors: PO
authors: Lang
authors: Health and Wellbeing academy, Anglia Ruskin University, CM1 1SQ Cambridge, UK. pierre-olivier.lang@chuv.ch.
authors: Richard
authors: R
authors: Aspinall
mesh_terms: D019587:Dietary Supplements; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007109:Immunity / Q000187:drug effects*; D056747:Immunomodulation / Q000187:drug effects*; D014611:Vaccination; D014612:Vaccines; D014807:Vitamin D / Q000276:immunology* / Q000494:pharmacology; D014815:Vitamins / Q000276:immunology* / Q000494:pharmacology
chemical_list: D014612:Vaccines; D014815:Vitamins; D014807:Vitamin D