title: A firmly hybridizable, DNA-like architecture with DAD/ADA- and ADD/DAA-type nonnatural base pairs as an extracellular genetic candidate.
abstract: We describe artificial DNA molecules exclusively consisting of four types of alkynyl C-nucleotides with nonnatural bases. The artificial DNA exhibited almost the same characteristics as natural DNA, such as in regard to the stepwise duplex and triplex formation and the right-handed higher-order structure with an antiparallel alignment fashion.
authors: Graduate School of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. chiba@pha.u-toyama.ac.jp inouye@pha.u-toyama.ac.jp.
authors: Wataru
authors: W
authors: Shirato
authors: Junya
authors: J
authors: Chiba
authors: Masahiko
authors: M
authors: Inouye
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D004247:DNA / Q000737:chemistry* / Q000235:genetics*; D015195:Drug Design; D005110:Extracellular Space / Q000235:genetics*; D008958:Models, Molecular; D009693:Nucleic Acid Hybridization
chemical_list: D004247:DNA