title: Osmotic demyelination syndrome in Intensive Care Unit.
abstract: Dyselectrolytemia, especially hyponatremia is a common occurrence in hospitalized patients, and a number of dreaded complications arise out of the disorder itself and its treatment. Osmotic demyelination syndrome develops secondary to rapid correction of hyponatremia. As the disease is rare and available literature from Intensive Care Units are limited, we report our retrospective observation over 5 years. Overall incidence was 2.5% with altered sensorium and hypokalemia as most common symptom and associated factor respectively. Isolated pontine involvement was in 41% and combined pontine, and extra-pontine lesions were found in 23% of cases. All patients received supportive therapy; out of which 2 died and complete neurological recovery was seen in 24% of patients. Our findings suggest that a well organized supportive therapy and multidisciplinary approach is of more concern than many available therapeutic modalities which are still to be proved.
authors: Department of Anesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
authors: Parnandi Bhaskar
authors: PB
authors: Rao
authors: Department of Critical Care Medicine, SGPGI, Lucknow, Uttar Pradesh, India.
authors: Afzal
authors: A
authors: Azim
authors: Department of Anesthesiology, Critical Care and Pain Medicine, Institute of Medical Sciences and SUM Hospital, SOA University, Bhubaneswar, Odisha, India.
authors: Neha
authors: N
authors: Singh
authors: Department of Critical Care Medicine, SGPGI, Lucknow, Uttar Pradesh, India.
authors: Arvind Kumar
authors: AK
authors: Baronia
authors: Department of Critical Care Medicine, SGPGI, Lucknow, Uttar Pradesh, India.
authors: Anand
authors: A
authors: Kumar
authors: Department of Critical Care Medicine, SGPGI, Lucknow, Uttar Pradesh, India.
authors: Banani
authors: B
authors: Poddar
keywords: Demyelination; Intensive Care Unit; hyponatremia; osmotic; syndrome