title: IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy.
abstract: OBJECTIVE
  There is now extensive evidence to support the involvement of inflammation in the course of epileptic seizures. Seizure-induced changes in serum IL-1β, IL-6 and IL-1Ra levels are reported in several studies. Serum cytokine levels may also be disturbed in inter-ictal period due to seizure activity.
  
  
  METHODS
  Twenty-one patients (12 women; mean age 35±12.3) with temporal lobe epilepsy (TLE), 17 patients (8 women; mean age 31.8±10.4) with extra-temporal lobe epilepsy (XLE) and 20 normal controls (10 women; mean age 35.6±8.8) were included in the study. Serum levels of IL-1β, IL-6 and IL-1Ra of the TLE, XLE groups in inter-ictal period and of the normal control group were compared.
  
  
  RESULTS
  All three cytokine levels are found to be significantly elevated in epilepsy patients when compared to controls (p<0.05). In TLE group, IL-1β serum levels were significantly higher than in the XLE group (p<0001).
  
  
  CONCLUSIONS
  The major findings in our study were increased levels of IL-1β, IL-6 and IL-1Ra in epileptic patients and high levels of IL-1β in TLE group. Our results support the existence of a chronic inflammatory state in epileptic patients.
authors: Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey. Electronic address: fatmairem@yahoo.com.
authors: Irem Fatma
authors: IF
authors: Uludag
authors: Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey.
authors: Tarik
authors: T
authors: Duksal
authors: Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey.
authors: Bedile Irem
authors: BI
authors: Tiftikcioglu
authors: Izmir Tepecik Educational and Research Hospital, Neurology Clinic, Turkey.
authors: Yasar
authors: Y
authors: Zorlu
authors: Dokuz Eylul University Faculty of Medicine, Department of Medical Biochemistry, Turkey.
authors: Feriha
authors: F
authors: Ozkaya
authors: Dokuz Eylul University Faculty of Medicine, Department of Medical Biochemistry, Turkey.
authors: Guldal
authors: G
authors: Kirkali
mesh_terms: D000328:Adult; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000097:blood*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D015850:Interleukin-6
keywords: Cytokines; Epilepsy; IL-1Ra; IL-1β; IL-6; Temporal lobe epilepsy