title: Effects of Wharton's jelly cells of the human umbilical cord on acute spinal cord injury in rats, and expression of interleukin-1β and nerve growth factor in spinal cord tissues.
abstract: To study the effects of Wharton's jelly cells (WJCs) on acute spinal cord injury (SCI), 81 rats were divided into a sham surgery group, a model group, and a WJC transplantation group (n = 27). Motor functions of the model and WJC transplantation groups were partially recovered, and the recovery was better in the latter group. The WJC transplantation group had integral spinal cord tissues. Compared with the model group, the WJC transplantation group expressed significantly less interleukin-1β (IL-1β) and more nerve growth factor (NGF) (P < 0.05). WJC transplantation changed the microenvironment of the SCI site, inhibited IL-1β expression, increased NGF expression, promoted the recovery of neurological function, and relieved secondary SCI.
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Cheng
authors: C
authors: Li
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Xiao
authors: X
authors: Chen
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Suchi
authors: S
authors: Qiao
authors: b Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA , Shenyang , P. R. China.
authors: Xinwei
authors: X
authors: Liu
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Chang
authors: C
authors: Liu
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Degang
authors: D
authors: Zhu
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Jiacan
authors: J
authors: Su
authors: a Department of Orthopedic Surgery , Changhai Hospital, The Second Military Medical University , Shanghai , P. R. China.
authors: Zhiwei
authors: Z
authors: Wang
mesh_terms: D000208:Acute Disease; D000818:Animals; D005260:Female; D005786:Gene Expression Regulation; D064593:Heterografts; D006801:Humans; D053583:Interleukin-1beta / Q000096:biosynthesis*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells; D020932:Nerve Growth Factor / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology / Q000628:therapy
chemical_list: C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D020932:Nerve Growth Factor
keywords: Wharton's jelly cells; interleukin-1β; nerve growth factor; spinal cord injury; umbilical cord