title: Antibacterial and antioxidant xanthones and benzophenone from garcinia smeathmannii.
abstract: A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2D NMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 µg/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.
authors: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
authors: Hugues
authors: H
authors: Fouotsa
authors: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.
authors: Alain Meli
authors: AM
authors: Lannang
authors: Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
authors: Jean Paul
authors: JP
authors: Dzoyem
authors: Department of Chemistry, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon.
authors: Simplice J N
authors: SJ
authors: Tatsimo
authors: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, Bielefeld, Germany.
authors: Beate
authors: B
authors: Neumann
authors: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
authors: Celine Djama
authors: CD
authors: Mbazoa
authors: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.
authors: Andrianambinina Andriamarolahy
authors: AA
authors: Razakarivony
authors: Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
authors: Augustin Ephrem
authors: AE
authors: Nkengfack
authors: Phytomedicine Programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.
authors: Jacobus N
authors: JN
authors: Eloff
authors: Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.
authors: Norbert
authors: N
authors: Sewald
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000254:growth & development; D029760:Garcinia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000604984:1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl)xanthone; C000604985:2,3'-dihydroxy-2',4,6-trimethoxybenzophenone; C505174:2-(3,7-dimethyl-2,6-octadienyl)-1,3,5,8-tetrahydroxyxanthone; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001577:Benzophenones; D039821:Monoterpenes; D010936:Plant Extracts; D014315:Triterpenes; D044004:Xanthones