title: Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides.
abstract: A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases. An antiproliferative effect was observed for compounds 17a and 17b: the growth inhibitory effect reaches the 50% in HepG2 and HT-29 cells and increases up to 56% in the SH-SY5Y cell line after 72 h of incubation at a 100 µM concentration.
authors: Dipartimento Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Via S.S. Annunziata, Messina 98168, Italy. sgiofre@unime.it.
authors: Salvatore V
authors: SV
authors: Giofrè
authors: Dipartimento Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Via S.S. Annunziata, Messina 98168, Italy. robromeo@unime.it.
authors: Roberto
authors: R
authors: Romeo
authors: Dipartimento Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Via S.S. Annunziata, Messina 98168, Italy. ccarnovale@unime.it.
authors: Caterina
authors: C
authors: Carnovale
authors: Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, Via P. Bucci, 12/C, Arcavacata di Rende (CS) 87036, Italy. raffaella.mancuso@unical.it.
authors: Raffaella
authors: R
authors: Mancuso
authors: Dipartimento Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Via S.S. Annunziata, Messina 98168, Italy. scirmi@unime.it.
authors: Santa
authors: S
authors: Cirmi
authors: Dipartimento Scienze del Farmaco e Prodotti per la Salute, Università di Messina, Via S.S. Annunziata, Messina 98168, Italy. mnavarra@unime.it.
authors: Michele
authors: M
authors: Navarra
authors: Dipartimento di Scienze Bio-mediche, Università di Catania, Via Androne 81, Catania 95124, Italy. agar@unict.it.
authors: Adriana
authors: A
authors: Garozzo
authors: Dipartimento Scienze del Farmaco, Università di Catania, Viale A. Doria 6, Catania 95125, Italy. ma.chiacchio@unict.it.
authors: Maria A
authors: MA
authors: Chiacchio
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D018716:Molecular Mimicry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007555:Isoxazoles; D009705:Nucleosides; D011743:Pyrimidines; C030986:pyrimidine