title: Application of bladder acellular matrix in urinary bladder regeneration: the state of the art and future directions.
abstract: Construction of the urinary bladder de novo using tissue engineering technologies is the "holy grail" of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM.
authors: Chair of Regenerative Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland.
authors: Marta
authors: M
authors: Pokrywczynska
authors: Department of Polymer Technology, Gdansk University of Technology, Narutowicza 11/12 Street, 80-233 Gdansk, Poland.
authors: Iga
authors: 0000-0002-6302-8436
authors: I
authors: Gubanska
authors: University of Bydgoszcz, Unii Lubelskiej 4C Street, 85-059 Bydgoszcz, Poland.
authors: Gerard
authors: G
authors: Drewa
authors: Chair of Regenerative Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24 Street, 85-092 Bydgoszcz, Poland ; Department of Urology, Nicolaus Copernicus Hospital, Batory 17-19 Street, 87-100 Torun, Poland.
authors: Tomasz
authors: T
authors: Drewa
mesh_terms: D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D019651:Plastic Surgery Procedures / Q000379:methods; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods; D001743:Urinary Bladder / Q000378:metabolism / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins