title: C-5'-Triazolyl-2'-oxa-3'-aza-4'a-carbanucleosides: Synthesis and biological evaluation.
abstract: A novel series of 2'-oxa-3'-aza-4'a-carbanucleosides, featured with a triazole linker at the 5'-position, has been developed by exploiting a click chemistry reaction of 5'-azido-2'-oxa-3'-aza-4'a-carbanucleosides with substituted alkynes. Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF cells with a CC50 in the range of 5.0-40 μM. The synthesized compounds do not show any antiviral activity.
authors: Dipartimento Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Via S.S. Annunziata, 98168 Messina, Italy.
authors: Roberto
authors: R
authors: Romeo
authors: Dipartimento Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Via S.S. Annunziata, 98168 Messina, Italy.
authors: Caterina
authors: C
authors: Carnovale
authors: Dipartimento Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Via S.S. Annunziata, 98168 Messina, Italy.
authors: Salvatore V
authors: SV
authors: Giofrè
authors: Dipartimento di Scienze del Farmaco, University of Catania, Via A. Doria 6, 95125-Catania, Italy.
authors: Maria A
authors: MA
authors: Chiacchio
authors: Dipartimento di Scienze Bio-Mediche, University of Catania,Via Androne 81, 95124 Catania, Italy.
authors: Adriana
authors: A
authors: Garozzo
authors: Dipartimento di Scienze del Farmaco, University of Catania, Via A. Doria 6, 95125-Catania, Italy.
authors: Emanuele
authors: E
authors: Amata
authors: Dipartimento Scienze del Farmaco e dei Prodotti per la Salute, University of Messina, Via S.S. Annunziata, 98168 Messina, Italy.
authors: Giovanni
authors: G
authors: Romeo
authors: Dipartimento di Scienze del Farmaco, University of Catania, Via A. Doria 6, 95125-Catania, Italy.
authors: Ugo
authors: U
authors: Chiacchio
keywords: 1,3-dipolar cycloaddition; 2’-oxa-3’-aza-4’a-carbanucleoside analogs; antitumor activity; click chemistry; nucleic acids