title: The role of TRPV1 in improving VSMC function and attenuating hypertension.
abstract: The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Currently, cumulative studies have demonstrated an interesting link between TRPV1 and cardiovascular diseases, including hypertension. Additionally, the protective effect of TRPV1 against hypertension and its related disorders has been proved to be partly involved with the improved action of vascular smooth muscle cells (VSMCs). This review focuses on the current knowledge of TRPV1 in improving VSMC function and attenuating hypertension.
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Ming-Jie
authors: MJ
authors: Zhang
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Yan-Wei
authors: YW
authors: Yin
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Bing-Hu
authors: BH
authors: Li
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Yun
authors: Y
authors: Liu
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Shao-Qiong
authors: SQ
authors: Liao
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Chang-Yue
authors: CY
authors: Gao
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.
authors: Jing-Cheng
authors: JC
authors: Li
authors: Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China. Electronic address: zhanglilidoctor@hotmail.com.
authors: Li-Li
authors: LL
authors: Zhang
mesh_terms: D000818:Animals; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D008955:Models, Cardiovascular; D018448:Models, Immunological; D009131:Muscle, Smooth, Vascular / Q000276:immunology* / Q000473:pathology; D032389:Myocytes, Smooth Muscle / Q000276:immunology* / Q000473:pathology; D000069336:Neurovascular Coupling / Q000276:immunology*; D050916:TRPV Cation Channels / Q000276:immunology*; D014664:Vasodilation / Q000276:immunology*
chemical_list: D050916:TRPV Cation Channels; C494482:TRPV1 protein, human
keywords: Calcium ion; Hypertension; Inflammation; Neurotransmitters; Transient receptor potential vanilloid type 1; Vascular smooth muscle cells