title: Poststreptococcal glomerulonephritis in a patient with essential thrombocytosis.
abstract: In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3.5 years. These characteristics make our case the first to be reported in the literature.
authors: Department of Nephrology, School of Medicine, Karadeniz Technical University.
authors: Sukru
authors: S
authors: Ulusoy
authors: Gulsum
authors: G
authors: Ozkan
authors: Mehmet
authors: M
authors: Sonmez
authors: Sevdegül
authors: S
authors: Mungan
authors: Rahman
authors: R
authors: Köseoğlu
authors: Muammer
authors: M
authors: Cansız
authors: Kübra
authors: K
authors: Kaynar
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005938:Glucocorticoids / Q000627:therapeutic use; D006401:Hematologic Agents / Q000627:therapeutic use; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications*; D013920:Thrombocythemia, Essential / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003176:Complement C3; D005938:Glucocorticoids; D006401:Hematologic Agents; D007075:Immunoglobulin M