title: Wheat aleurone fractions and plasma n-3 fatty acids in rats.
abstract: The main aim of this study was to compare the effects of two wheat aleurone (WA) fractions on circulating n-3 fatty acids in rats. We demonstrated that only the fraction able to induce the highest urinary excretion of polyphenol metabolites (>1µmol) resulted in a significant increase in plasma level of Eicosapentanoic acid (+22%, p < 0.05). While other constituents of whole wheat can be involved in this response, our data suggest that cereals containing high levels of phenolic compounds can increase blood n-3 without affecting n-6 fatty acids. Further studies are required to confirm this hypothesis and explore the underlying biological mechanisms.
authors: Laboratoire TIMC-IMAG CNRS UMR 5525, Equipe PRETA, Cœur et Nutrition, Université Joseph Fourier , Grenoble I , France .
authors: Fayçal
authors: F
authors: Ounnas
authors: Patricia
authors: P
authors: Salen
authors: Christine
authors: C
authors: Demeilliers
authors: Luca
authors: L
authors: Calani
authors: Francesca
authors: F
authors: Scazzina
authors: Florence
authors: F
authors: Hazane-Puch
authors: Francois
authors: F
authors: Laporte
authors: Camilla
authors: C
authors: Melegari
authors: Daniele
authors: D
authors: Del Rio
authors: Michel
authors: M
authors: de Lorgeril
mesh_terms: D000818:Animals; D002523:Edible Grain / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014908:Triticum / Q000378:metabolism*
chemical_list: D015525:Fatty Acids, Omega-3
keywords: n−3 long chain fatty acids; phenolic acids; wheat aleurone