title: Environmental estrogen bisphenol A and autoimmunity.
abstract: Over the past few years, there has been evidence of the increasing prevalence of autoimmune diseases. Autoimmune diseases consist of many complex disorders of unknown etiology resulting in immune responses to self-antigens. The immune system, and its function, is under complex and integrated control and its disruption can be triggered by multiple factors. Autoimmunity development is influenced by multiple factors and is thought to be a result of interactions between genetic and environmental factors. Here, we review the role of a specific environmental factor, bisphenol A (BPA), in the pathogenesis of autoimmune diseases. BPA belongs to the group of environmental estrogens that have been identified as risk factors involved in the development of autoimmune diseases.
authors: 1st Department of Internal Medicine, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia.
authors: I
authors: I
authors: Jochmanová
authors: 1st Department of Internal Medicine, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia.
authors: Z
authors: Z
authors: Lazúrová
authors: 1st Department of Internal Medicine, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia.
authors: M
authors: M
authors: Rudnay
authors: Department of Medical Physiology, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia.
authors: I
authors: I
authors: Bačová
authors: Department of Medical and Clinical Biochemistry and LABMED, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia.
authors: M
authors: M
authors: Mareková
authors: 1st Department of Internal Medicine, Faculty of Medicine, P. J. Šafárik University, Košice, Slovakia ivica.lazurova@upjs.sk.
authors: I
authors: I
authors: Lazúrová
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000503:physiopathology; D015551:Autoimmunity; D001559:Benzhydryl Compounds / Q000009:adverse effects* / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007107:Immune System; D010636:Phenols / Q000009:adverse effects* / Q000276:immunology; D012307:Risk Factors; D000098826:Bisphenol A Compounds
chemical_list: D001324:Autoantigens; D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Autoimmunity; bisphenol A; environmental estrogens