title: Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging.
abstract: To determine how different methods of normalizing for global cerebral blood flow (gCBF) affect image quality and sensitivity to cortical activation, pulsed arterial spin labeling (pASL) scans obtained during a visual task were normalized by either additive or multiplicative normalization of modal gCBF. Normalization by either method increased the statistical significance of cortical activation by a visual stimulus. However, image quality was superior with additive normalization, whether judged by intensity histograms or by reduced variability within gray and white matter.
authors: Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA.
authors: Stephanie B
authors: SB
authors: Stewart
authors: Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA.
authors: Jonathan M
authors: JM
authors: Koller
authors: Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Radiology, Washington University School of Medicine , St Louis, MO , USA.
authors: Meghan C
authors: MC
authors: Campbell
authors: Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Radiology, Washington University School of Medicine , St Louis, MO , USA ; Departments of Anatomy and Neurobiology, Washington University School of Medicine , St Louis, MO , USA ; Division of Biology and Biomedical Sciences, Washington University School of Medicine , St Louis, MO , USA ; Programs in Physical Therapy and Occupational Therapy, Washington University School of Medicine , St Louis, MO , USA.
authors: Joel S
authors: JS
authors: Perlmutter
authors: Department of Neurology, Washington University School of Medicine , St Louis, MO , USA ; Department of Psychiatry, Washington University School of Medicine , St Louis, MO , USA ; Department of Radiology, Washington University School of Medicine , St Louis, MO , USA ; Departments of Anatomy and Neurobiology, Washington University School of Medicine , St Louis, MO , USA ; Division of Biology and Biomedical Sciences, Washington University School of Medicine , St Louis, MO , USA.
authors: Kevin J
authors: KJ
authors: Black
keywords: ASL; Arterial spin labeling; Cerebral blood flow; Cerebral blood flow measurement; Functional magnetic resonance imaging; Parkinson’s disease; fMRI