title: The role of shed placental DNA in the systemic inflammatory syndrome of preeclampsia.
abstract: Preeclampsia is a syndrome occurring only in pregnancy characterized by systemic maternal inflammation and associated with the presence of the placenta. How these 2 aspects of the disease are linked has been the subject of numerous theories and ideas. Recently, there has been increasing interest in DNA shed from the placenta into the maternal circulation as a potential agent initiating the inflammatory response. This review will discuss the current evidence and future directions for placental DNA as the linking factor in preeclampsia in the context of other hypotheses.
authors: Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
authors: James D R
authors: JD
authors: Hartley
authors: Department of Pathology, University of Cambridge, Cambridge, United Kingdom.
authors: Brian J
authors: BJ
authors: Ferguson
authors: Department of Pathology, University of Cambridge, Cambridge, United Kingdom. Electronic address: am485@cam.ac.uk.
authors: Ashley
authors: A
authors: Moffett
mesh_terms: D055252:Cell-Derived Microparticles / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004247:DNA / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000276:immunology / Q000378:metabolism; D020738:Leptin / Q000276:immunology / Q000378:metabolism; D010920:Placenta / Q000098:blood supply / Q000276:immunology / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology / Q000378:metabolism*; D014327:Trophoblasts / Q000166:cytology; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism
chemical_list: D016207:Cytokines; D020738:Leptin; D004247:DNA; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1
keywords: inflammation; placental DNA; preeclampsia