title: Transcriptional control and hormonal response of thermogenic fat.
abstract: Obesity and its associated metabolic diseases present a major public health problem around the world. The discovery that thermogenic fat is active in adult humans has sparked a renewal of interest in the study of its development and function and in the feasibility of using modulators of thermogenesis to work against obesity. In recent years, it has been shown that there are at least two distinct types of thermogenic fat cells: brown and beige fat. In this review, we discuss the transcriptional mediators of thermogenesis and the signaling molecules that regulate thermogenic cells. We also review the effects of thermogenic fat activation on whole-body metabolic parameters and evaluate the increasing evidence that activating thermogenesis in humans can be a viable method of ameliorating obesity. In these discussions, we highlight targets that can potentially be stimulated or modified in anti-obesity treatments.
authors: Life Sciences Institute Department of Molecular and Integrative Physiology University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA Life Sciences Institute Department of Molecular and Integrative Physiology University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA.
authors: Margo P
authors: MP
authors: Emont
authors: Life Sciences Institute Department of Molecular and Integrative Physiology University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA.
authors: Hui
authors: H
authors: Yu
authors: Life Sciences Institute Department of Molecular and Integrative Physiology University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA Life Sciences Institute Department of Molecular and Integrative Physiology University of Michigan, 210 Washtenaw Avenue, LSI, RM5115A, Ann Arbor, Michigan 48109, USA wujunz@umich.edu.
authors: Jun
authors: J
authors: Wu
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D022722:Thermogenesis; D014158:Transcription, Genetic
chemical_list: D006728:Hormones
keywords: adaptive thermogenesis; beige adipocyte; brown adipocyte; diabetes; obesity