title: Association of irisin concentrations with the presence of diabetic nephropathy and retinopathy.
abstract: OBJECTIVE
  Irisin, a recently identified myokine, is involved in the protection of mice against obesity and diabetes. This study aims to determine the serum and vitreous concentrations of irisin in patients with diabetic nephropathy and diabetic retinopathy.
  
  
  METHODS
  A total of 178 patients with type 2 diabetes mellitus, as well as 22 type 2 diabetes mellitus patients without diabetic retinopathy and 35 patients with proliferative diabetic retinopathy were enrolled in this study.
  
  
  RESULTS
  Serum irisin concentrations were significantly elevated in the control group compared with those in type 2 diabetes mellitus patients. Furthermore, type 2 diabetes mellitus patients with macroalbuminuria exhibited significantly lower serum irisin concentrations than the controls and type 2 diabetes mellitus patients with normoalbuminuria and microalbuminuria. Simple regression analysis showed that the serum irisin concentrations in type 2 diabetes mellitus patients were negatively correlated with age, fasting plasma glucose, homeostasis model assessment of insulin resistance, blood urea nitrogen, creatinine, and positively correlated with creatinine clearance and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers treatment. Proliferative diabetic retinopathy patients showed significantly decreased serum and vitreous irisin concentrations compared with the control group and type 2 diabetes mellitus patients without diabetic retinopathy. Furthermore, decreased serum and vitreous irisin concentrations were found in type 2 diabetes mellitus patients without diabetic retinopathy than those in the controls.
  
  
  CONCLUSIONS
  Irisin concentrations are associated with the presence of diabetic nephropathy and diabetic retinopathy.
authors: Department of Endocrinology, Qilu Hospital at Qingdao, Shandong University, Qingdao, People's Republic of China.
authors: Wenchao
authors: W
authors: Hu
authors: Department of Blood Transfusion, Qilu Hospital at Qingdao, Shandong University, Qingdao, People's Republic of China.
authors: Rui
authors: R
authors: Wang
authors: Department of Cataract, Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Institute of Ophthalmology, Tianjin, People's Republic of China.
authors: Jun
authors: J
authors: Li
authors: Department of Laboratory, Metabolic Disease Hospital, Tianjin Medical University, Tianjin, People's Republic of China.
authors: Jie
authors: J
authors: Zhang
authors: Department of Endocrinology, Qilu Hospital at Qingdao, Shandong University, Qingdao, People's Republic of China wangwenhui@medmail.com.cn.
authors: Wenhui
authors: W
authors: Wang
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003928:Diabetic Nephropathies / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D014822:Vitreous Body / Q000378:metabolism
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: Irisin; diabetic nephropathy; diabetic retinopathy