title: General CuBr2-catalyzed highly enantioselective approach for optically active allenols from terminal alkynols.
abstract: Here, we show a CuBr2-catalyzed approach for a highly enantioselective synthesis (93-99% ee) of allenols from aldehydes and terminal alkynols with the absolute configuration being controlled by applying readily available (R)- or (S)-α,α-diphenylprolinol.
authors: Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China.
authors: Xin
authors: X
authors: Huang
authors: Tao
authors: T
authors: Cao
authors: Yulin
authors: Y
authors: Han
authors: Xingguo
authors: X
authors: Jiang
authors: Weilong
authors: W
authors: Lin
authors: Jiasheng
authors: J
authors: Zhang
authors: Shengming
authors: S
authors: Ma
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D055620:Optical Phenomena; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D001965:Bromides; C408079:cupric bromide; D003300:Copper