title: Simultaneous determination of four organotins in food packaging by high-performance liquid chromatography-tandem mass spectrometry.
abstract: A simple method based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous determination of organotins-tri-n-butyltin chloride (TBT), triphenyltin chloride (TPT), dibutyltin dichloride (DBT), and diphenyltin dichloride (DPT)-in plastic food packaging. Samples were prepared by ultrasonic extraction with dichloromethane, followed by dissolution in acetonitrile containing 0.1% formic acid, and purification by an MCX column. The extracts were analyzed by LC-MS/MS in multiple reaction monitoring and positive modes with a C18 column; elution was carried out with a gradient of 0.1% formic acid and methanol containing 0.1% formic acid. The limits of detection for TBT, TPT, DBT, and DPT were 0.1, 0.6, 0.8, and 0.3 μg kg(-1), respectively. The recovery of organotins in spiked samples ranged from 68% to 113% (relative standard deviation: 0.4-4.2%). The proposed method was successfully employed to identify the target analytes in plastic packaging used for milk and cake.
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Tengfei
authors: T
authors: Li
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China. Electronic address: 0891syx@163.com.
authors: Yongxin
authors: Y
authors: She
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Miao
authors: M
authors: Wang
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Guangyang
authors: G
authors: Liu
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Hailong
authors: H
authors: Yu
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China. Electronic address: w_jing2001@126.com.
authors: Jing
authors: J
authors: Wang
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Shanshan
authors: S
authors: Wang
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Fen
authors: F
authors: Jin
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Maojun
authors: M
authors: Jin
authors: Institute of Quality Standards & Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China; Key Laboratory of Agro-Product Safety and Quality, Ministry of Agriculture, Beijing 100081, PR China.
authors: Hua
authors: H
authors: Shao
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018857:Food Packaging; D057230:Limit of Detection; D016014:Linear Models; D009947:Organotin Compounds / Q000032:analysis*; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry; D014220:Trialkyltin Compounds / Q000032:analysis
chemical_list: D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C063612:diphenyltin; C011559:tributyltin; C012594:triphenyltin chloride; C020735:dibutyldichlorotin
keywords: Food packaging; LC–MS/MS; Organotin compounds; Simultaneous determination