title: A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro.
abstract: A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β-amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
authors: Ali Ali
authors: AA
authors: El-Gamal
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Mohamed Farag
authors: MF
authors: Abd-El-Halim
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia / Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
authors: Ashraf Taha
authors: AT
authors: Kalil
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Omer Ahmed
authors: OA
authors: Basudan
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Adnan Jathlan
authors: AJ
authors: Al-Rehaily
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Mohamed Shamim
authors: MS
authors: Ahmad
authors: Pharmacology Department, Facultyof Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Kamal Hussin
authors: KH
authors: El-Tahir
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Shaza Mohamed
authors: SM
authors: Al-Massarani
authors: Pharmacognosy Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors: Wael Moustafa
authors: WM
authors: Abdel-Mageed
mesh_terms: D031289:Albizzia / Q000737:chemistry; D000818:Animals; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006168:Guinea Pigs; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047090:beta-Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C000598096:albactam; D047090:beta-Lactams