title: AKAP5 signaling complexes: focal points and functional properties.
abstract: Kinase Anchoring Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transduction. As a typical member, AKAP5 which consisting of three orthologues: bovine AKAP75, rodent AKAP150 and human AKAP79, is the best known model in the anchoring and targeting properties. It is shown that AKAP5 can bind β2-adrenergic receptor, which is a member of GPCR superfamily, and orchestrate the interactions of various protein kinases, protein phosphatases and cytoskeletal element. AKAP5 is originally identified as a component of the postsynaptic density in neurons and plays a vital role in modulating neuronal activities. Subsequently, the AKAP5 complexes are also detected in other tissues and participated in various processes.
authors: Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Yanjing
authors: Y
authors: Guo
authors: Central Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Tao
authors: T
authors: Bo
authors: Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Xinli
authors: X
authors: Zhou
authors: Institute of Endocrinology, Shandong Academy of Clinical Medicine, Jinan, China.
authors: Ling
authors: L
authors: Gao
authors: Department of Clinical Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Yong
authors: Y
authors: Wang
authors: Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
authors: Jiajun
authors: J
authors: Zhao
mesh_terms: D054758:A Kinase Anchor Proteins / Q000502:physiology*; D000818:Animals; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D054758:A Kinase Anchor Proteins; C487775:AKAP5 protein, human