title: Highly pathogenic Avian Influenza A(H5N1) virus infection among workers at live bird markets, Bangladesh, 2009-2010.
abstract: The risk for influenza A(H5N1) virus infection is unclear among poultry workers in countries where the virus is endemic. To assess H5N1 seroprevalence and seroconversion among workers at live bird markets (LBMs) in Bangladesh, we followed a cohort of workers from 12 LBMs with existing avian influenza surveillance. Serum samples from workers were tested for H5N1 antibodies at the end of the study or when LBM samples first had H5N1 virus-positive test results. Of 404 workers, 9 (2%) were seropositive at baseline. Of 284 workers who completed the study and were seronegative at baseline, 6 (2%) seroconverted (7 cases/100 poultry worker-years). Workers who frequently fed poultry, cleaned feces from pens, cleaned food/water containers, and did not wash hands after touching sick poultry had a 7.6 times higher risk for infection compared with workers who infrequently performed these behaviors. Despite frequent exposure to H5N1 virus, LBM workers showed evidence of only sporadic infection.
authors: Sharifa
authors: S
authors: Nasreen
authors: Salah Uddin
authors: SU
authors: Khan
authors: Stephen P
authors: SP
authors: Luby
authors: Emily S
authors: ES
authors: Gurley
authors: Jaynal
authors: J
authors: Abedin
authors: Rashid Uz
authors: RU
authors: Zaman
authors: Badrul Munir
authors: BM
authors: Sohel
authors: Mustafizur
authors: M
authors: Rahman
authors: Kathy
authors: K
authors: Hancock
authors: Min Z
authors: MZ
authors: Levine
authors: Vic
authors: V
authors: Veguilla
authors: David
authors: D
authors: Wang
authors: Crystal
authors: C
authors: Holiday
authors: Eric
authors: E
authors: Gillis
authors: Katharine
authors: K
authors: Sturm-Ramirez
authors: Joseph S
authors: JS
authors: Bresee
authors: Mahmudur
authors: M
authors: Rahman
authors: Timothy M
authors: TM
authors: Uyeki
authors: Jacqueline M
authors: JM
authors: Katz
authors: Eduardo
authors: E
authors: Azziz-Baumgartner
mesh_terms: D000293:Adolescent; D000328:Adult; D001459:Bangladesh / Q000453:epidemiology; D000067565:Farmers; D005260:Female; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification* / Q000235:genetics; D007251:Influenza, Human / Q000453:epidemiology* / Q000266:history / Q000635:transmission / Q000821:virology*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012703:Serotyping; D055815:Young Adult
keywords: Bangladesh; highly pathogenic avian influenza; incidence; influenza; live bird market; poultry worker; risk factors; seroconversion; seroprevalence; subtype H5N1; transmission; viruses