title: Cannabinoid agonist rescues learning and memory after a traumatic brain injury.
abstract: Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial. We tested the hypothesis that posttraumatic brain injury administration of a cannabinoid 1 receptor agonist can rescue deficits in learning and memory. Young adult male rats were subjected to a moderately severe controlled cortical impact brain injury, with a subset given postinjury i.p. injections of a cannabinoid receptor agonist. Utilizing novel object recognition and the morris water task, we found that the brain-injured animals treated with the agonist showed a marked recovery.
authors: Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada.
authors: Marium
authors: M
authors: Arain
authors: Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada.
authors: Maida
authors: M
authors: Khan
authors: Regeneration Unit in Neurobiology Core Facility, University of Calgary Calgary, Alberta, Canada.
authors: Laura
authors: L
authors: Craig
authors: Alberta Children's Hospital Research Institute, University of Calgary Calgary, Alberta, Canada ; Department of Biology, University of Hawai'i at Hilo Hilo, Hawai'i, USA.
authors: Stan T
authors: ST
authors: Nakanishi