title: Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection.
abstract: We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr).
authors: Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ, 07030, USA.
authors: Jingmao
authors: J
authors: Chi
authors: Newark Beth Israel Medical Center, Newark, NJ, 07112, USA.
authors: Thet
authors: T
authors: Zaw
authors: Newark Beth Israel Medical Center, Newark, NJ, 07112, USA.
authors: Iliana
authors: I
authors: Cardona
authors: Newark Beth Israel Medical Center, Newark, NJ, 07112, USA.
authors: Mujtaba
authors: M
authors: Hosnain
authors: Newark Beth Israel Medical Center, Newark, NJ, 07112, USA.
authors: Neha
authors: N
authors: Garg
authors: Newark Beth Israel Medical Center, Newark, NJ, 07112, USA.
authors: Heather R
authors: HR
authors: Lefkowitz
authors: Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, NJ, 07030, USA.
authors: Peter
authors: P
authors: Tolias
authors: Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ, 07030, USA.
authors: Henry
authors: H
authors: Du
keywords: (160.4236) Nanomaterials; (170.5660) Raman spectroscopy; (170.6510) Spectroscopy, tissue diagnostics; (240.6695) Surface-enhanced Raman scattering