title: Lung cancer screening: where have we been? Where are we going?
abstract: Recent evidence suggests that lung cancer screening with low-dose chest CT (LDCT) has a moderate net benefit on lung cancer mortality when applied to a high-risk population. This review article examines this evidence in light of the earlier failures of lung cancerscreening using chest radiography and/or sputum cytology. Harms associated with LDCT lung cancer screening include false positive results, false negative results, incidental findings, radiation exposure, and overdiagnosis. A number of issues related to implementation are unresolved.
authors: Paul V
authors: PV
authors: Carlile
mesh_terms: D002986:Clinical Trials as Topic; D055088:Early Detection of Cancer; D019317:Evidence-Based Medicine; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality; D008403:Mass Screening / Q000379:methods; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D011857:Radiographic Image Interpretation, Computer-Assisted; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000009:adverse effects / Q000379:methods*