title: Receptor tyrosine kinase signaling regulates replication of the peste des petits ruminants virus.
abstract: In this study, we found out that blocking the receptor tyrosine kinase (RTK) signaling in Vero cells by tryphostin AG879 impairs the in vitro replication of the peste des petits ruminants virus (PPRV). A reduced virus replication in Trk1-knockdown (siRNA) Vero cells confirmed the essential role of RTK in the virus replication, in particular a specific regulation of viral RNA synthesis. These data represent the first evidence that the RTK signaling regulates replication of a morbillivirus.
authors: K
authors: K
authors: Chaudhary
authors: K K
authors: KK
authors: Chaubey
authors: S V
authors: SV
authors: Singh
authors: N
authors: N
authors: Kumar
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D029021:Peste-des-Petits-Ruminants / Q000201:enzymology* / Q000821:virology; D018107:Peste-des-petits-ruminants virus / Q000235:genetics / Q000502:physiology*; D020917:Receptor, trkA / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014709:Vero Cells; D014779:Virus Replication
chemical_list: D020917:Receptor, trkA
keywords: PPR virus; receptor tyrosine kinase; RNA synthesis.