title: Relationship between white matter microstructure abnormalities and ADHD symptomatology in adolescents.
abstract: The present study sought to evaluate whether white matter microstructure abnormalities observed in a cohort of adolescents with attention-deficit/hyperactivity disorder (ADHD) have specific relationships with either or both Hyperactivity/Impulsivity and Inattentive ADHD symptom domains that would support a dimensional view of ADHD as adopted in the DSM-V. Diffusion tensor imaging (DTI) data were acquired on 22 adolescents diagnosed with ADHD. Multiple regression analyses were performed to determine whether scalar DTI measures in 13 tracts-of-interest demonstrated meaningful associations with Hyperactivity/Impulsivity or Inattentive symptom severity. Fractional anisotropy and radial diffusivity measures of white matter integrity exhibited significant linear relationships with Hyperactivity/Impulsivity and Inattentive symptom severity. However, only radial diffusivity in the right superior longitudinal fasciculus was specifically linked to Inattentive symptom severity and not Hyperactivity/Impulsivity symptom severity. Our results provide preliminary evidence that symptom domains in ADHD are linked to neuroanatomical substrates and confirm the value in examining ADHD from a dimensional perspective.
authors: Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, ONRC, Whitehall Building, Hartford, CT 06106, USA; Center for Medical Imaging and Visualization (CMIV), Linköping University, SE-581 85 Linköping, Sweden. Electronic address: suzanne.witt@liu.se.
authors: Suzanne T
authors: ST
authors: Witt
authors: Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, ONRC, Whitehall Building, Hartford, CT 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA.
authors: Michael C
authors: MC
authors: Stevens
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000378:metabolism / Q000473:pathology; D066127:White Matter / Q000378:metabolism / Q000473:pathology*
keywords: ADHD; Adolescents; DTI; Dimensionality; Superior longitudinal fasciculus