title: Fueling up skeletal muscle to reduce obesity: A TrkB story.
abstract: Targeting TrkB signaling could represent a good therapeutic strategy to prevent obesity. In this issue of Chemistry & Biology, Chan et al. report the efficacy of 7,8-DHT, a TrkB agonist, in preventing obesity in female mice. The underlying molecular mechanisms behind this activity seem to involve increased energy expenditure in skeletal muscle.
authors: Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
authors: Ji Youn
authors: JY
authors: Youn
authors: Divisions of Molecular Medicine and Cardiology, Departments of Anesthesiology and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: hcai@mednet.ucla.edu.
authors: Hua
authors: H
authors: Cai
mesh_terms: D000818:Animals; D005260:Female; D047309:Flavones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000819:agonists*; D009765:Obesity / Q000188:drug therapy*
chemical_list: D047309:Flavones; D008562:Membrane Glycoproteins