title: A review of the impact of biologics on surgical complications in Crohn's disease.
abstract: Anti-tumor necrosis factor therapy has revolutionized the treatment of Crohn's disease. Despite the increased use in the past decade and a half, a majority of patients with Crohn's disease with ultimately require operative management of their disease. No clear consensus has been made in the literature regarding the surgical outcomes in patients who have been exposed to anti-tumor necrosis factor therapy. This review highlights the most recent and relevant literature regarding the safety and effects of anti-tumor necrosis factor use in the perioperative period.
authors: Departments of *Surgery, and †Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Melissa I
authors: MI
authors: Chang
authors: Benjamin L
authors: BL
authors: Cohen
authors: Alexander J
authors: AJ
authors: Greenstein
mesh_terms: D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D001688:Biological Products / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology*; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects* / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha