title: Intraorbital Irrigation of Amphotericin B in the Treatment of Rhino-Orbital Mucormycosis.
abstract: The aim of this study was to describe a modified technique of intraorbital irrigation of amphotericin B in the treatment of rhino-orbital mucormycosis. A 38-year-old man was diagnosed with rhino-orbital mucormycosis and subsequently underwent orbital and sinus debridement with postoperative intraorbital irrigation of amphotericin B. Daily irrigation of amphotericin B was infused in the orbit with measures taken to avoid iatrogenic toxicity to the ocular surface and gastrointestinal tract. The use of local amphotericin B irrigation directly in the orbit allowed for local control of infection without orbital exenteration, a good cosmetic outcome and excellent postoperative visual acuity. The published reports on the use of intraorbital irrigation with amphotericin B in mucormycosis infections were reviewed and the technique used at the institution was outlined.
authors: Department of Ophthalmology and Visual Sciences, Division of Ophthalmic Plastic and Reconstructive Surgery, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, U.S.A.
authors: Zachary P
authors: ZP
authors: Joos
authors: Bhupendra C K
authors: BC
authors: Patel
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D004322:Drainage / Q000379:methods; D015821:Eye Infections, Fungal / Q000628:therapy*; D006801:Humans; D008297:Male; D009091:Mucormycosis / Q000628:therapy*; D013508:Ophthalmologic Surgical Procedures / Q000379:methods; D009915:Orbit / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000628:therapy*; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B