title: Quantifying the evidence for the risk of metabolic syndrome and its components following androgen deprivation therapy for prostate cancer: a meta-analysis.
abstract: BACKGROUND
  No meta-analysis is yet available for the risk of metabolic syndrome (MetS) following androgen deprivation therapy (ADT) for men with prostate cancer. To summarize the evidence for the link between ADT and MetS or its components quantitatively with a meta-analysis including all studies published to date.
  
  
  METHODS
  PubMed and Embase were searched using predefined inclusion criteria to perform meta-analyses on the association between metabolic syndrome, hyperglycemia, diabetes, hypertension, dyslipidemia or obesity and androgen deprivation therapy in patients with prostate cancer. Random effects methods were used to estimate pooled relative risks (RRs) and 95% confidence intervals (CI).
  
  
  RESULTS
  A total of nine studies was included. There was a positive association between ADT and risk of MetS (RR: 1.75 (95% CI: 1.27-2.41)). Diabetes was the only MetS component present in more than 3 studies, and also showed an increased risk following ADT (RR: 1.36 (95% CI: 1.17-1.58)).
  
  
  CONCLUSIONS
  This is the first quantitative summary addressing the potential risk of MetS following ADT in men with PCa. The positive RRs indicate that there is a need to further elucidate how type and duration of ADT affect these increased risks of MetS and diabetes as the number of men with PCa treated with ADT is increasing.
authors: King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom.
authors: Cecilia
authors: C
authors: Bosco
authors: King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom; Department of Oncology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.
authors: Danielle
authors: D
authors: Crawley
authors: Karolinska Institute, CLINTEC Department, Stockholm, Sweden.
authors: Jan
authors: J
authors: Adolfsson
authors: Department of Oncology, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.
authors: Sarah
authors: S
authors: Rudman
authors: King's College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Group, London, United Kingdom.
authors: Mieke
authors: M
authors: Van Hemelrijck
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000209:etiology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D000726:Androgen Antagonists