title: Current State and Future Challenges of Mass Spectrometry Imaging for Clinical Research.
abstract: The ability of mass spectrometry imaging (MSI) to localize panels of biomolecules in tissues, without prior knowledge of their presence and in a label-free manner, has led to a rapid and substantial impact in clinical and pharmacological research, uncovering biomolecular changes associated with disease and providing low cost imaging of pharmaceuticals. This Feature article will give an introduction to the capabilities and role of MSI in the clinical analysis of patient tissues and discusses those improvements that are necessary for the progression of MSI toward routine clinical application.
authors: †Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.|‡Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Ruben D
authors: RD
authors: Addie
authors: †Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
authors: Benjamin
authors: B
authors: Balluff
authors: ‡Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Judith V M G
authors: JV
authors: Bovée
authors: ‡Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
authors: Hans
authors: H
authors: Morreau
authors: †Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.|§Fondazione Pisana per la Scienza ONLUS, Pisa, Italy.
authors: Liam A
authors: LA
authors: McDonnell
mesh_terms: D035843:Biomedical Research; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*