title: Store-operated calcium entry: unveiling the calcium handling signalplex.
abstract: Store-operated Ca(2+) entry (SOCE) is an important mechanism for Ca(2+) influx in non-excitable cells, also present in excitable cells. The activation of store-operated channels (SOCs) is finely regulated by the filling state of the intracellular agonist-sensitive Ca(2+) compartments, and both, the mechanism of sensing the Ca(2+) stores and the nature and functional properties of the SOCs, have been a matter of intense investigation and debate. The identification of STIM1 as the endoplasmic reticulum Ca(2+) sensor and both Orai1, as the pore-forming subunit of the channels mediating the Ca(2+)-selective store-operated current, and the members of the TRPC subfamily of proteins, as the channels mediating the cation-permeable SOCs, has shed new light on the underlying events. This review summarizes the initial hypothesis and the current advances on the mechanism of activation of SOCE.
authors: Department of Physiology, University of Extremadura, Cáceres, Spain.
authors: Pedro C
authors: PC
authors: Redondo
authors: Department of Physiology, University of Extremadura, Cáceres, Spain.
authors: Juan A
authors: JA
authors: Rosado
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D002462:Cell Membrane / Q000378:metabolism; D004331:Drosophila melanogaster; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains; D008565:Membrane Proteins / Q000378:metabolism; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000378:metabolism; D000071740:ORAI1 Protein; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D000071737:Stromal Interaction Molecule 1
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000071740:ORAI1 Protein; C510746:ORAI1 protein, human; C103530:STIM1 protein, human; D000071737:Stromal Interaction Molecule 1; D002118:Calcium
keywords: Lipid rafts; Orai1; STIM1; Store-operated calcium entry; TRPC channels