title: Diagnose human colonic tissues by terahertz near-field imaging.
abstract: Based on a terahertz (THz) pipe-based near-field imaging system, we demonstrate the capability of THz imaging to diagnose freshly surgically excised human colonic tissues. Through THz near-field scanning the absorbance of the colonic tissues, the acquired images can clearly distinguish cancerous tissues from healthy tissues fast and automatically without pathological hematoxylin and eosin stain diagnosis. A statistical study on 58 specimens (20 healthy tissues and 38 tissues with tumor) from 31 patients (mean age: 59 years; range: 46 to 79 years) shows that the corresponding diagnostic sensitivity and specificity on colonic tissues are both 100%. Due to its capability to perform quantitative analysis, our study indicates the potential of the THz pipe-based near-field imaging for future automation on human tumor pathological examinations.
authors: Hua
authors: H
authors: Chen
authors: Shihua
authors: S
authors: Ma
authors: Xiumei
authors: X
authors: Wu
authors: Wenxing
authors: W
authors: Yang
authors: Tian
authors: T
authors: Zhao
mesh_terms: D000368:Aged; D003106:Colon / Q000000981:diagnostic imaging*; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods; D013194:Staining and Labeling; D055069:Terahertz Imaging / Q000379:methods*