title: Depression-associated ARNTL and PER2 genetic variants in psychotic disorders.
abstract: Circadian rhythm disturbances overlap between psychotic disorders, e.g. schizophrenia, and major depression. We hypothesized that circadian gene variants previously associated with unipolar depression would be overrepresented also in patients with psychotic disorder. Six genetic polymorphisms in ARNTL, PER2 and CRY2 were genotyped in 566 schizophrenia spectrum disorder patients and 926 controls. The rs2290036-C variant of ARNTL was over-represented in psychosis patients, and the variants rs934945-G and rs10462023-G of PER2 were associated with a more severe psychotic disorder. The directions of these genetic associations were in line with those previously identified for depression.
authors: School of Nursing, Shandong University , Jinan , China .
authors: Jia J
authors: JJ
authors: Liu
authors: Dzana
authors: D
authors: Sudic Hukic
authors: Yvonne
authors: Y
authors: Forsell
authors: Martin
authors: M
authors: Schalling
authors: Urban
authors: U
authors: Ösby
authors: Catharina
authors: C
authors: Lavebratt
mesh_terms: D056930:ARNTL Transcription Factors / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056926:CLOCK Proteins / Q000235:genetics; D002940:Circadian Rhythm / Q000235:genetics*; D003863:Depression / Q000235:genetics; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D014644:Genetic Variation / Q000502:physiology; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D056950:Period Circadian Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics; D055815:Young Adult
chemical_list: D056930:ARNTL Transcription Factors; C538960:BMAL1 protein, human; C421902:PER2 protein, human; D056950:Period Circadian Proteins; D056926:CLOCK Proteins
keywords: ARNTL; CRY2; PER2; circadian; psychosis; severity