title: Organocatalytic Enantioselective Oxidative C-H Alkenylation and Arylation of N-Carbamoyl Tetrahydropyridines and Tetrahydro-β-carbolines.
abstract: The first organocatalytic enantioselective C-H alkenylation and arylation reactions of N-carbamoyl tetrahydropyridines and tetrahydro-β-carbolines (THCs) are described. The metal-free processes represent an efficient and straightforward approach to a variety of structurally and electronically diverse α-substituted tetrahydropyridines and THCs in good yields with excellent regio- and enantioselectivities. Preliminary control experiments provide important insights into the reaction mechanism.
authors: Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012 (P.R. China).
authors: Xigong
authors: X
authors: Liu
authors: Zhilin
authors: Z
authors: Meng
authors: Chengkun
authors: C
authors: Li
authors: Hongxiang
authors: H
authors: Lou
authors: Lei
authors: L
authors: Liu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D011725:Pyridines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D001897:Boronic Acids; D002243:Carbolines; D011725:Pyridines
keywords: CH functionalization; asymmetric organocatalysis; carbamates; tetrahydro-β-carbolines; tetrahydropyridines