title: Novel superhydrophilic poly(l-lactic acid-co-ε-caprolactone)/fibrinogen electrospun patch for rat abdominal wall reconstruction.
abstract: A novel superhydrophilic hybrid scaffold was created by electrospinning a mixture of poly(l-lactic acid-co-ε-caprolactone) and formulated fibrinogen. The hybrid scaffolds possess the combined benefits of each individual component, such as moderate mechanical strength and excellent biocompatibility. In vitro studies also revealed that endothelial cells seeded on the hybrid scaffolds achieved a relatively high level of cell attachment after three days of culture and a significant increase in the proliferation rate after seven days of culture, compared with pure fibrinogen or poly(l-lactic acid-co-ε-caprolactone) scaffolds. A comparative study of hybrid and pure poly(l-lactic acid-co-ε-caprolactone) patches was performed in an abdominal wall defect model in rats. In both groups, implants degraded by six months, but muscle reconstruction was only observed in the hybrid patch group.
authors: School of Materials Science and Engineering, Shanghai JiaoTong University, Shanghai, China Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Zhang
authors: Z
authors: Liu
authors: Department of General Surgery, Huadong Hospital Affiliated to Fudan Univercity, Shanghai, China.
authors: Shaojie
authors: S
authors: Li
authors: Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Ling
authors: L
authors: Su
authors: School of Materials Science and Engineering, Shanghai JiaoTong University, Shanghai, China.
authors: Kang
authors: K
authors: Sun
authors: School of Materials Science and Engineering, Shanghai JiaoTong University, Shanghai, China Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Xujun
authors: X
authors: Wu
authors: Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Feng
authors: F
authors: Wu
authors: Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Weihong
authors: W
authors: Huang
authors: Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China.
authors: Li
authors: L
authors: Yang
authors: Department of General Surgery, Huadong Hospital Affiliated to Fudan Univercity, Shanghai, China.
authors: Jianxiong
authors: J
authors: Tang
authors: Shanghai Pine & Power Biotech Co., Ltd., Shanghai, China Institute of Peripheral Vascular Surgery, Fudan University, Shanghai, China hhb@shsongli.com johnxiong@china.com.
authors: Hongbing
authors: H
authors: He
mesh_terms: D034861:Abdominal Wall; D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D005340:Fibrinogen / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C550605:poly(lactic acid-co-epsilon-caprolactone); D005340:Fibrinogen
keywords: Tissue regeneration; electrospun patch; hybrid scaffold; superhydrophilic material