title: Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia.
abstract: OBJECTIVE
  To determine whether abnormal macular thickness in myopic anisometropic amblyopia differed after amblyopia treatment. Furthermore, to investigate whether effect of treatment on macular thickness was associated with subject age or improvement in stereoacuity.
  
  
  METHODS
  Seventeen children (mean age: 9.0 [±3.0] years, ranging from 5.7-13.9 years) with myopic anisometropic amblyopia (visual acuity [VA] in amblyopic eyes: 20/80-20/400) were recruited and treated with 16-week refractive correction, followed by an additional 16-week refractive correction and patching. Macular thickness, best-corrected VA, and stereoacuity were measured both before and after amblyopia treatment. Factorial repeated-measures analysis of variance was performed to determine whether macular thickness in amblyopic eyes changed after amblyopia treatment.
  
  
  RESULTS
  Mean baseline VA in the amblyopic eye was 1.0 ± 0.3 logMAR and improved to 0.7 ± 0.3 after amblyopia treatment (P < 0.0001). The interaction between eye and amblyopia treatment was statistically significant for average foveal thickness (P = 0.040). There was no treatment effect on fellow eyes (P = 0.245); however, the average foveal thickness in the amblyopic eye was significantly reduced after amblyopia treatment (P = 0.049). No statistically significant interactions were found for the other macular thickness parameters (P > 0.05).
  
  
  CONCLUSIONS
  Abnormal central macula associated with myopic anisometropic amblyopia tended to be thinner following amblyopia treatment with no significant changes in peripheral macular thickness.
authors: Yi
authors: Y
authors: Pang
authors: Kelly A
authors: KA
authors: Frantz
authors: Sandra
authors: S
authors: Block
authors: Geoffrey W
authors: GW
authors: Goodfellow
authors: Christine
authors: C
authors: Allison
mesh_terms: D000293:Adolescent; D000550:Amblyopia / Q000150:complications / Q000473:pathology / Q000628:therapy*; D015858:Anisometropia / Q000150:complications / Q000473:pathology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005139:Eyeglasses; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009216:Myopia / Q000150:complications / Q000473:pathology / Q000628:therapy*; D012165:Retinal Ganglion Cells / Q000473:pathology; D012683:Sensory Deprivation; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity