title: Targeting liver X receptors in cancer therapeutics.
abstract: Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses. There is now accumulating evidence to support the involvement of LXRs in a variety of malignancies and the potential efficacy of their ligands in these diseases. This Review summarizes the discovery and characterization of LXRs and their ligands, their effects and mechanisms in preclinical cancer models, and the future directions of basic and translational LXR research in cancer therapeutics.
authors: Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5056, USA.
authors: Chin-Yo
authors: CY
authors: Lin
authors: 1] Center for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5056, USA. [2] Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge SE-141 83, Sweden.
authors: Jan-Åke
authors: JÅ
authors: Gustafsson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D000071518:Liver X Receptors; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D057093:Orphan Nuclear Receptors / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors