title: δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
abstract: δ-Catenin and β-catenin belong to different subfamilies of armadillo proteins but share some common binding partners, such as E-cadherin. This is the first study that demonstrated a novel common binding partner for δ-catenin and β-catenin, lymphoid enhancer factor-1 (LEF-1). We found that the N-terminus of δ-catenin (amino acids 85-325) bound to the middle region of LEF-1 unlike β-catenin. Overexpressed δ-catenin entered the nucleus and inhibited LEF-1-mediated transcriptional activity in Bosc23 and DLD-1 cell lines. The current study provided novel insights that will provide a better understanding of the effects of δ-catenin on Wnt/LEF-1-mediated transcriptional activity.
authors: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, 500-757, Korea.
authors: Yongfeng
authors: Y
authors: He
authors: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, 500-757, Korea.
authors: Hyunkyoung
authors: H
authors: Ki
authors: College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, 540-950, Korea.
authors: Hangun
authors: H
authors: Kim
authors: College of Pharmacy and Research Institute for Drug Development, Chonnam National University, Gwangju, 500-757, Korea.
authors: Kwonseop
authors: K
authors: Kim
mesh_terms: D051177:Catenins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D051821:Lymphoid Enhancer-Binding Factor 1 / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction; D014158:Transcription, Genetic; D051153:Wnt Proteins / Q000378:metabolism; D000095002:Delta Catenin
chemical_list: D051177:Catenins; C497573:LEF1 protein, human; D051821:Lymphoid Enhancer-Binding Factor 1; D051153:Wnt Proteins; D000095002:Delta Catenin
keywords: LEF-1; β-catenin; δ-catenin