title: Two positive tuberculosis cases in the late Nigrovits family, 18th century, Vác, Hungary.
abstract: Two mummies of the Hungarian mummy collection from Vác were the subjects of anthropological, paleopathological, radiological, paleomicrobiological, paleohistological and paleoproteomic studies. Both individuals belonged to the same family. The father, József Nigrovits (No 29), died at the age of 55 on the 11th of November 1793; his son, Antal Nigrovits (No 54), died on the 16th of July 1803, at the age of 22. They lived in the 18th century in Vác, a small town in northern Hungary. The macroscopic examination of the son showed a severely deformed neck and back region; the father has no visible mark of any illnesses. As earlier researches showed that tuberculosis was widespread in the community, the etiology of these deformities was examined. The paleomicrobiological results found that both individuals were infected with tuberculosis. Although they suffered from TB, the CT scan data of the bodies and their 3D reconstructions showed no skeletal evidence of tuberculosis. The deformity of the son turned to be a developmental abnormality of unknown origin, but no Pott's gibbus was present.
authors: Department of Anthropology, Hungarian Natural History Museum, Budapest, Hungary. Electronic address: szikossy@nhmus.hu.
authors: Ildikó
authors: I
authors: Szikossy
authors: Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: palfigy@bio.u-szeged.hu.
authors: György
authors: G
authors: Pálfi
authors: Department of Biological Anthropology, University of Szeged, Szeged, Hungary. Electronic address: balinte@bio.u-szeged.hu.
authors: Erika
authors: E
authors: Molnár
authors: Semmelweis University, Department of Diagnostic Radiology and Oncotherapy, Budapest, Hungary. Electronic address: kinga.karlking@gmail.com.
authors: Kinga
authors: K
authors: Karlinger
authors: Semmelweis University, Department of Diagnostic Radiology and Oncotherapy, Budapest, Hungary. Electronic address: drkovbal@gmail.com.
authors: Balázs K
authors: BK
authors: Kovács
authors: Semmelweis University, Department of Diagnostic Radiology and Oncotherapy, Budapest, Hungary. Electronic address: korom.csaba@gmail.com.
authors: Csaba
authors: C
authors: Korom
authors: Department of Anatomy, University Medical School Göttingen, Göttingen, Germany. Electronic address: mschult1@gwdg.de.
authors: Michael
authors: M
authors: Schultz
authors: Department of Anatomy, University Medical School Göttingen, Göttingen, Germany. Electronic address: tschmidt-schultz@web.de.
authors: Tyede H
authors: TH
authors: Schmidt-Schultz
authors: Centre for Clinical Microbiology, Division of Infection & Immunity, University College London, London, UK; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: spigelman@btinternet.com.
authors: Mark
authors: M
authors: Spigelman
authors: Centre for Clinical Microbiology, Division of Infection & Immunity, University College London, London, UK; Centre for the History of Medicine, Division of Biosciences, University College London, UK. Electronic address: h.donoghue@ucl.ac.uk.
authors: Helen D
authors: HD
authors: Donoghue
authors: Department of Anthropology, Hungarian Natural History Museum, Budapest, Hungary. Electronic address: kustar@nhmus.hu.
authors: Ágnes
authors: Á
authors: Kustár
authors: Department of Anthropology, Hungarian Natural History Museum, Budapest, Hungary. Electronic address: papi@nhmus.hu.
authors: Ildikó
authors: I
authors: Pap
mesh_terms: D004269:DNA, Bacterial / Q000235:genetics; D049671:History, 18th Century; D006801:Humans; D006814:Hungary; D016916:Joint Deformities, Acquired / Q000235:genetics / Q000266:history / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009106:Mummies; D009169:Mycobacterium tuberculosis / Q000235:genetics; D010164:Paleopathology; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed; D014394:Tuberculosis, Osteoarticular / Q000235:genetics / Q000266:history* / Q000473:pathology; D055815:Young Adult
chemical_list: D004269:DNA, Bacterial
keywords: Hungary; Mummies; Mycobacterium tuberculosis; Paleomicrobiology; Paleopathology; Vác