title: [Recently identified GPR17 receptors--characteristics and role in pathology of the nervous system].
abstract: Newly identified metabotropic GPR17 receptors are structurally related to purinergic P2Y receptors and cysteinyl leukotriene receptors. Re- cent studies showed that they play an important role in maturation of oligodendrocyte precursor cells. This review describes structure and pharmacological characterization of GPR17 receptors. It also summarizes knowledge about role of GPR17 receptors in physiology and patho- logy of nervous system, with special attention to remyelination processes.
authors: Dorota
authors: D
authors: Wypych
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D009422:Nervous System Diseases / Q000378:metabolism*; D009424:Nervous System Physiological Phenomena / Q000502:physiology; D009836:Oligodendroglia / Q000166:cytology / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C121670:GPR17 protein, human; D043562:Receptors, G-Protein-Coupled