title: Flucloxacillin and fusidic acid-associated neutropenia in a patient with periaortic abscess: rare side effects of commonly used antibiotics.
abstract: The use of long-term antibiotics for deep-seated infections is very common, and is associated with many clinically significant side effects. In this report we describe the history of a 48-year-old man who attended West Suffolk Hospital with nausea and vomiting, and was subsequently found to have a deep-seated infection following his repeat aortic valve replacement. He completed a 7-week course of intravenous flucloxacillin and oral fusidic acid, however, prior to finishing this course a random blood test revealed a neutrophil count of zero. He was re-admitted to hospital with fever, and was treated accordingly as per the trust's neutropenic sepsis protocol with the addition of growth colony stimulating factor (GCSF). His neutrophil count recovered after 3 days and has remained within the normal range ever since.
authors: Department of Neurosciences, Addenbrookes Hospital, Cambridge, UK.
authors: Negin
authors: N
authors: Damali Amiri
authors: Department of Medicine, West Suffolk Hospital, Bury St Edmunds, UK.
authors: Nishan
authors: N
authors: Wijenaike
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001021:Aortic Valve / Q000601:surgery; D000082882:Bicuspid Aortic Valve Disease; D005334:Fever / Q000188:drug therapy / Q000209:etiology; D005436:Floxacillin / Q000008:administration & dosage / Q000009:adverse effects*; D005672:Fusidic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006330:Heart Defects, Congenital / Q000601:surgery*; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced* / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology
chemical_list: D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor; D005436:Floxacillin; D005672:Fusidic Acid