title: Plant antimicrobial peptides as potential anticancer agents.
abstract: Antimicrobial peptides (AMPs) are part of the innate immune defense mechanism of many organisms and are promising candidates to treat infections caused by pathogenic bacteria to animals and humans. AMPs also display anticancer activities because of their ability to inactivate a wide range of cancer cells. Cancer remains a cause of high morbidity and mortality worldwide. Therefore, the development of methods for its control is desirable. Attractive alternatives include plant AMP thionins, defensins, and cyclotides, which have anticancer activities. Here, we provide an overview of plant AMPs anticancer activities, with an emphasis on their mode of action, their selectivity, and their efficacy.
authors: Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km 9.5 Carretera Morelia-Zinapécuaro, Posta Veterinaria, 58893 Morelia, MICH, Mexico.
authors: Jaquelina Julia
authors: JJ
authors: Guzmán-Rodríguez
authors: Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km 9.5 Carretera Morelia-Zinapécuaro, Posta Veterinaria, 58893 Morelia, MICH, Mexico.
authors: Alejandra
authors: 0000-0003-3441-2989
authors: A
authors: Ochoa-Zarzosa
authors: Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edif. B1, Ciudad Universitaria, 58030 Morelia, MICH, Mexico.
authors: Rodolfo
authors: R
authors: López-Gómez
authors: Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Km 9.5 Carretera Morelia-Zinapécuaro, Posta Veterinaria, 58893 Morelia, MICH, Mexico.
authors: Joel E
authors: 0000-0002-3269-9202
authors: JE
authors: López-Meza
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D047169:Cyclotides / Q000627:therapeutic use; D023082:Defensins / Q000627:therapeutic use; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects* / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010944:Plants / Q000737:chemistry; D054809:Thionins / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D000970:Antineoplastic Agents; D047169:Cyclotides; D023082:Defensins; D054809:Thionins