title: [Relationship between endothelial dysfunction and mechanisms of systemic inflammation in left heart remodeling in patients with bronchial asthma].
abstract: The aim of the work was to study clinical and pathophysiological features of endothelial dysfunction, structural and functional state of the left heart in patients with bronchial asthma (BA). The study included 290 patients. 250 of them presented with moderate or severe BA during exacerbation and within 12 months after the onset of observation, 40 healthy volunteers served as controls. The endothelial function was disturbed in 63 and 74% of the patients with moderate and severe BA respectively. They showed reduced endothelium-dependent vasodilation in combination with a significant increase of the plasma sDC31/ sPECAM-1 level. It is concluded that patients with BA develop structural and functional changes in the left ventricular myocardium proportional to the severity of BA which leads to diastolic dysfunction.
authors: E A
authors: EA
authors: Sobko
authors: I A
authors: IA
authors: Solov'eva
authors: A Iu
authors: AIu
authors: Kraposhina
authors: N G
authors: NG
authors: Riazanova
authors: S S
authors: SS
authors: Vtiurina
authors: A B
authors: AB
authors: Salmina
authors: I B
authors: IB
authors: Demko
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000097:blood*; D000328:Adult; D001249:Asthma / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*; D012129:Respiratory Function Tests / Q000379:methods; D012307:Risk Factors; D012720:Severity of Illness Index; D013223:Statistics as Topic; D014664:Vasodilation; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D051997:ADP-ribosyl Cyclase 1