title: Highly enantioselective hydrogenation of ο-alkoxy tetrasubstituted enamides catalyzed by a Rh/(R,S)-JosiPhos catalyst.
abstract: Rh/(R,S)-JosiPhos complex-catalyzed asymmetric hydrogenation of o-alkoxy tetrasubstituted enamides has been achieved, and it furnished a set of β-amino alcohol analogues in high yields and excellent enantiomeric excesses (>99% conversion, up to 99% ee).This method provides valuable chiral building blocks in chiral pharmaceuticals and useful motifs for catalysts.
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors: Jingjing
authors: J
authors: Meng
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors: Min
authors: M
authors: Gao
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors: Hui
authors: H
authors: Lv
authors: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China.
authors: Xumu
authors: X
authors: Zhang
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D008024:Ligands; D009942:Organometallic Compounds; D012238:Rhodium