title: Effects of vitamin D on blood pressure and cardiovascular risk factors: a randomized controlled trial.
abstract: Vitamin D deficiency is a risk factor for arterial hypertension, but randomized controlled trials showed mixed effects of vitamin D supplementation on blood pressure (BP). We aimed to evaluate whether vitamin D supplementation affects 24-hour systolic ambulatory BP monitoring values and cardiovascular risk factors. The Styrian Vitamin D Hypertension Trial is a single-center, double-blind, placebo-controlled study conducted from June 2011 to August 2014 at the endocrine outpatient clinic of the Medical University of Graz, Austria. We enrolled 200 study participants with arterial hypertension and 25-hydroxyvitamin D levels below 30 ng/mL. Study participants were randomized to receive either 2800 IU of vitamin D3 per day as oily drops (n=100) or placebo (n=100) for 8 weeks. Primary outcome measure was 24-hour systolic BP. Secondary outcome measures were 24-hour diastolic BP, N-terminal-pro-B-type natriuretic peptide, QTc interval, renin, aldosterone, 24-hour urinary albumin excretion, homeostasis model assessment-insulin resistance, triglycerides, high-density lipoprotein cholesterol, and pulse wave velocity. A total of 188 participants (mean [SD] age, 60.1 [11.3] years; 47% women; 25-hydroxyvitamin D, 21.2 [5.6] ng/mL) completed the trial. The mean treatment effect (95% confidence interval) for 24-hour systolic BP was -0.4 (-2.8 to 1.9) mm Hg (P=0.712). Triglycerides increased significantly (mean change [95% confidence interval], 17 [1-33] mg/dL; P=0.013), but no further significant effects were observed for secondary outcomes. Vitamin D supplementation in hypertensive patients with low 25-hydroxyvitamin D has no significant effect on BP and several cardiovascular risk factors, but it was associated with a significant increase in triglycerides.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT02136771.
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.). stefan.pilz@chello.at.
authors: Stefan
authors: S
authors: Pilz
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Martin
authors: M
authors: Gaksch
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Katharina
authors: K
authors: Kienreich
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Martin
authors: M
authors: Grübler
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Nicolas
authors: N
authors: Verheyen
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Astrid
authors: A
authors: Fahrleitner-Pammer
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Gerlies
authors: G
authors: Treiber
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Christiane
authors: C
authors: Drechsler
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Bríain
authors: B
authors: Ó Hartaigh
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Barbara
authors: B
authors: Obermayer-Pietsch
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Verena
authors: V
authors: Schwetz
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Felix
authors: F
authors: Aberer
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Julia
authors: J
authors: Mader
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Hubert
authors: H
authors: Scharnagl
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Andreas
authors: A
authors: Meinitzer
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Elisabeth
authors: E
authors: Lerchbaum
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Jacqueline M
authors: JM
authors: Dekker
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Armin
authors: A
authors: Zittermann
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Winfried
authors: W
authors: März
authors: From the Division of Endocrinology and Metabolism, Department of Internal Medicine (S.P., M.G., K.K., A.F.P., G.T., B.O.-P., V.S., F.A., J.M., E.L.), Department of Cardiology (M.G., N.V., A.T.), and Clinical Institute of Medical and Chemical Laboratory Diagnostics (H.S., A.M., W.M.), Medical University of Graz, Graz, Austria; Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, The Netherlands (S.P., J.M.D.); Division of Nephrology, Department of Medicine I, University of Würzburg, Würzburg, Germany (C.D.); Department of Radiology, Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital and the Weill Cornell Medical College (B.o.H.), NY; Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany (A.Z.); Synlab Academy, Synlab Services GmbH, Mannheim, Germany (W.M.); Specialist Clinic for Rehabilitation Bad Aussee, Bad Aussee, Austria (A.T.); and Department of Cardiology, Campus Virchow, Charité University, Berlin, Germany (A.T.).
authors: Andreas
authors: A
authors: Tomaschitz
mesh_terms: D000368:Aged; D001317:Austria; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001795:Blood Pressure Determination; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D014807:Vitamin D
keywords: blood pressure; cholecalciferol; placebo; randomized controlled trial; vitamin D