title: Effects of Paclitaxel on the Ability of Aspirin and Clopidogrel to Inhibit Platelet Aggregation.
abstract: The aim of this study was to investigate the effects of different paclitaxel concentrations on platelet aggregation induced by adenosine diphosphate (ADP). This experiment involved platelet suspensions that were obtained from fasting morning blood specimens from healthy adult male volunteers aged 22 to 28 years. The effect of paclitaxel on platelet aggregation induced by ADP and the inhibition rate of platelet aggregation were calculated in 6 groups with varying concentrations of paclitaxel, respectively. The optimal incubation time and concentration of ADP were 10 minutes and 10 μmol/mL, respectively. When the concentration of paclitaxel increased, platelet aggregation induced by ADP increased accordingly. When the concentration of paclitaxel exceeded 0.1 ng/mL, the ability of ADP to induce platelet aggregation increased significantly with increasing paclitaxel concentrations. In all the 3 experimental groups, that is A, C, and AC groups, the ability to inhibit platelet aggregation was weakened as paclitaxel concentration increased. Paclitaxel can enhance platelet aggregation induced by ADP, and this ability was observed to increase as paclitaxel concentration increased. In conclusion, paclitaxel can reduce the ability of aspirin, clopidogrel, and aspirin combined with clopidogrel to inhibit platelet aggregation. Furthermore, the ability to inhibit platelet aggregation was weakened as paclitaxel concentration increased in all 3 experimental groups.
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Shu
authors: S
authors: Zhang
authors: Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
authors: Changli
authors: C
authors: Sun
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Hai
authors: H
authors: Hu
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Yarong
authors: Y
authors: He
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Yuanchang
authors: Y
authors: Yao
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors: Yu
authors: Y
authors: Cao
authors: Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, China zhizng@126.com.
authors: Zhi
authors: Z
authors: Zeng
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D000077144:Clopidogrel; D004359:Drug Therapy, Combination / Q000379:methods*; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D000077144:Clopidogrel; D013988:Ticlopidine; D017239:Paclitaxel; D001241:Aspirin
keywords: aspirin; clopidogrel; paclitaxel; platelet aggregation; stent thrombosis