title: Antibiotic therapy in the management of atopic dermatitis.
abstract: Atopic dermatitis (AD), also known as atopic eczema, is a syndrome characterized by a chronic eczematous dermatitis, with associated pruritus, characteristic age-specific morphology and distribution of lesions and recurrent nature. Secondary infections in patients with AD are very common and difficult to treat. S. aureus colonizes almost all eczematous lesions in atopic patients and releases several super-antigens and exotoxins (i.e., toxic shock syndrome toxin-1, enterotoxins A-D, etc.), which sustain inflammatory reactions and promote tachyphylaxis. The topical antibiotics most commonly prescribed for mild/moderate secondary infections are gentamicin, fusidic acid and mupirocine. This article reviews existing therapeutic options and provides guidance for the management of secondary skin infection among patients with AD.
authors: Unit of Pediatric Dermatology, Department of Medicine, University of Padua, Padua, Italy - anna.bellonifortina@gmail.com.
authors: A
authors: A
authors: Belloni Fortina
authors: L
authors: L
authors: Neri
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000942:Antigens, Bacterial / Q000276:immunology; D002648:Child; D003876:Dermatitis, Atopic / Q000150:complications*; D004198:Disease Susceptibility; D004202:Disinfectants / Q000008:administration & dosage; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005672:Fusidic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D012867:Skin / Q000382:microbiology; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D012973:Sodium Hypochlorite / Q000008:administration & dosage; D013207:Staphylococcal Skin Infections / Q000188:drug therapy* / Q000209:etiology; D013211:Staphylococcus aureus / Q000276:immunology; D018089:Superantigens / Q000276:immunology; D015163:Superinfection
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D004202:Disinfectants; D018089:Superantigens; D005672:Fusidic Acid; D012973:Sodium Hypochlorite