title: Intralesional 5-fluorouracil in keloid treatment: a systematic review.
abstract: In the 1990s, 5-flourouracil (5-FU) was introduced as a treatment for keloids; however, there is still no consensus on its use. In order to guide clinical practice, a systematic review of the clinical evidence on the effectiveness of 5-FU in keloid treatment was carried out. Eight databases were searched on 10 September 2014 using the terms "keloid" and "5-FU", together with all synonyms of these terms. Two reviewers selected original research reports using 5-FU alone or combined with a maximum of 2 other therapies. Eighteen papers were found that reported either on intralesional 5-FU alone, or on 5-FU combined with triamcinolone acetonide (TAC:5-FU) or excision, including 482 patients. 5-FU treatment was effective in 45-96% of patients, but only TAC:5-FU may perform better than TAC alone. Due to a poor level of evidence, further research should establish the superiority of repeated intralesional TAC:5-FU injections over TAC alone with several doses and injection schedules.
authors: Department of plastic and reconstructive and hand surgery ErasmusMC, Erasmus University Medical Center Rotterdam, 3015CN Rotterdam, The Netherlands. e.bijlard@erasmusmc.nl.
authors: Eveline
authors: E
authors: Bijlard
authors: Sanne
authors: S
authors: Steltenpool
authors: Frank B
authors: FB
authors: Niessen
mesh_terms: D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000175:diagnosis / Q000188:drug therapy*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage
chemical_list: D003879:Dermatologic Agents; D005938:Glucocorticoids; D014222:Triamcinolone Acetonide; D005472:Fluorouracil