title: Metabolic syndrome and its components are strongly associated with an inflammatory state and insulin resistance in the pediatric population.
abstract: BACKGROUND
  Endothelial inflammation and insulin resistance (IR) begin in childhood and constitute the pathophysiological basis of Metabolic Syndrome (MS). The increase levels in plasma of inflammatory markers such as high sensitive PCR (hsPCR), plasminogen activator inhibitor 1 (PAI-1) and tests suggestive of IR such as Insulin (Ins) and alanine aminotransferase (ALT) have been associated with MS in adults, but have not been studied in children.
  
  
  OBJECTIVE
  Correlate the presence of MS and its components with the inflammatory and IR markers seen in the pediatric population.
  
  
  METHODS
  Cross-sectional study of 337 children (10,9±9,7 years) whose levels of hsPCR, PAI-1, Ins and ALT were determined, along with their association with MS and its individual components.
  
  
  RESULTS
  37 children had MS (10,4%). The frequency of MS components was: abdominal obesity 38,5%, hypertension (HTN) 21,3%, hypertriglyceridemia 17,8%, HDL 21,3% and hyperglycemia 1,4%. hsPCR, PAI-1, ALT and Ins were higher in the presence of MS and increased progressively when components were came together.
  
  
  CONCLUSIONS
  The pediatric population segment with MS had a higher concentration of hsPCR, PAI-1, Ins and ALT.These levels increase proportionally MS components add up, suggesting that even before diagnosis criteria are fulfilled there is a inflammatory state.
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. Calourei@gmail.com.
authors: Carolina
authors: C
authors: Loureiro
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Andrea
authors: A
authors: Godoy
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Alejandro
authors: A
authors: Martínez
authors: Department of Endocrinology. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Carmen
authors: C
authors: Campino
authors: Pediatric Nephrology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Marlene
authors: M
authors: Aglony
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Rodrigo
authors: R
authors: Bancalari
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Carolina
authors: C
authors: Mendoza
authors: Department of Public Health. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Jaime
authors: J
authors: Cerda
authors: Department of Endocrinology. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Cristian
authors: C
authors: Carvajal
authors: Pediatric Cardiology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Pilar
authors: P
authors: Arnaiz
authors: Department of Endocrinology. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Carlos
authors: C
authors: Fardella
authors: Pediatric Endocrinology Unit. Pontificia Universidad Católica de Chile. Chile. hgarciab@gmail.com.
authors: Hernan
authors: H
authors: García
mesh_terms: D000293:Adolescent; D001786:Blood Glucose; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D018836:Inflammation Mediators / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism* / Q000473:pathology*
chemical_list: D001786:Blood Glucose; D018836:Inflammation Mediators; D008055:Lipids