title: Metabolic Pattern of Asymptomatic Hip-Prosthesis by 18F-FDG-Positron-Emission-Tomography.
abstract: BACKGROUND
  Joint replacement is a procedure with a major impact on the quality of life of patients with joint degenerative disease or traumatic injuries. However, some patients develop symptoms after the intervention caused by mechanical loosening or infection. Metabolic imaging by 18F-FDG-PET investigated in these patients isoften hampered by low specificity for diagnosis of possible septic vs. mechanical loosening. The reason for this shortcoming is to our opinion the unawareness of physiological remodeling processes that could be seen in asymptomatic patients.
  
  
  OBJECTIVE
  In order to overcome this drawback, we aimed to find out the physiological metabolic functional pattern in asymptomatic patients with implanted hip prosthesis.
  
  
  METHODS
  Twelve patients (6 males, 6 females); mean age 73 ± 7 (range 58 - 91) years were prospectively enrolled in the study. The patients were admitted to our department for oncological referral with implanted hip prostheses. All patients explained no symptoms with regard to their implanted prosthesis. The attenuation corrected images were used for analysis.
  
  
  RESULTS
  Fourteen hip prostheses in 12 patients were visually analyzed. Seven out of 14 prostheses among 12 patients showed focal periprosthetic enhanced metabolism, two of which showed two sites of enhanced uptake; whereas, the remaining five prostheses showed singular hypermetabolic areas within the periprosthetic site. The remaining seven prostheses in the other five patients showed no periprosthetic-enhanced uptake.
  
  
  CONCLUSIONS
  Of the asymptomatic patients investigated, 58% showed focal enhanced periprosthetic glucose metabolism. This finding should be taken into consideration as a more probable unspecific metabolic pattern for correct interpretation of 18F-FDG-PET studies in patients with suspected septic loosening of the hip prosthesis.
authors: Department of Nuclear Medicine, Clinical Center University of Sarajevo, Bolnicka, Sarajevo, Bosnia and Herzegovina.
authors: Nermina
authors: N
authors: Beslic
authors: Department of Radiology, Medical University of Graz, Austria.
authors: Daniel
authors: D
authors: Heber
authors: Department of Radiology, Medical University of Graz, Austria.
authors: Rainer
authors: R
authors: Walter Lipp
authors: Department of Nuclear Medicine with PET-Center, Wilhelminenspital, Montleart straße 37, 1160 Vienna, Austria.
authors: Charlotte
authors: C
authors: Sonneck-Koenne
authors: Department of Nuclear Medicine with PET-Center, Wilhelminenspital, Montleart straße 37, 1160 Vienna, Austria.
authors: Peter
authors: P
authors: Knoll
authors: Department of Nuclear Medicine with PET-Center, Wilhelminenspital, Montleart straße 37, 1160 Vienna, Austria.
authors: Siroos
authors: S
authors: Mirzaei
keywords: 18F- FDG; Arthroplasty; PET; Prosthesis Infection; Prosthesis Loosening