title: Adult stem-like cells in kidney.
abstract: Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. Kidney tissue regeneration is well confirmed in several lower vertebrates such as fish, and the repair of nephrons after tubular damages is commonly observed after renal injury. Even in adult mammal kidney, renal progenitor cell or system is reportedly presents suggesting that adult stem-like cells in kidney can be practical clinical targets for kidney diseases. However, it is still unclear if kidney stem cells or stem-like cells exist or not. In general, stemness is defined by several factors such as self-renewal capacity, multi-lineage potency and characteristic gene expression profiles. The definite use of stemness may be obstacle to understand kidney regeneration, and here we describe the recent broad findings of kidney regeneration and the cells that contribute regeneration.
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Keiichi
authors: K
authors: Hishikawa
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Osamu
authors: O
authors: Takase
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Masahiro
authors: M
authors: Yoshikawa
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Taro
authors: T
authors: Tsujimura
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Masaomi
authors: M
authors: Nangaku
authors: Keiichi Hishikawa, Osamu Takase, Masahiro Yoshikawa, Taro Tsujimura, Masaomi Nangaku, Tsuyoshi Takato, Department of Advanced Nephrology and Regenerative Medicine, the University of Tokyo, Tokyo 113-8655, Japan.
authors: Tsuyoshi
authors: T
authors: Takato
keywords: CD133; CD24; ES cell; Induced pluripotent stem; Label-retaining cells; SP cells; Sca-1; Stem cell; rKS56