title: Impact of smoking on guided tissue regeneration using a biocomposite poly (lactic-co-glycolic) acid/sub-micron size hydroxyapatite with a rubber dam as an alternative barrier.
abstract: The purpose of our study was to critically evaluate the results obtained from a guided tissue regeneration technique after 12 months using a bocomposite poly (lactic-co-glycolic) acid/sub-micron size hydroxyapatite (PLGA/HA) with a rubber dam as a barrier in smoking and non-smoking patients. We selected 36 patients (18 current smokers and 18 non-smokers) diagnosed with chronic advanced periodontitis with a periodontal site (probing depth [PD] >5) amenable to regenerative surgery. Twelve months after surgery, the periodontal parameters were found to have statistically improved, when non-smokers were compared with smokers, in: PD reduction (6.3 ± 2.1 mm vs. 3.6 ± 1.9 mm); CAL gain (4.4 ± 1.1 vs. 2.8 ± 2.2 mm); recession (1.8 ± 1.4 mm vs. 0.8 ± 0.9 mm); and hard tissue fill (4.7 ± 0.8 mm vs. 2.8 ± 2.1 mm). Furthermore, since we found PD baseline differences between groups, smoking seemed not to influence the outcomes achieved (CAL gain and ΔREC) 12 months post surgery with respect to PD baseline. The use of PLGA/HA with a rubber dam significantly improved the periodontal parameters in both smoking and non-smoking subjects. This improvement was nevertheless lower in smokers than the non-smokers, confirming the negative impact of smoking on periodontal regeneration.
authors: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
authors: D
authors: D
authors: Stramazzotti
authors: University of Cagliari, Dental School, Cagliari, Italy.
authors: C
authors: C
authors: Coiana
authors: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy.
authors: A
authors: A
authors: Zizzi
authors: MS Statistical Center, Italian National Research Center on Aging (I.N.R.C.A.), Ancona, Italy.
authors: L
authors: L
authors: Spazzafumo
authors: Dentistry, Departamento de Odontología, Facultad de Ciencias de la Salud, CEU-Cardenal Herrera University, Valencia, Spain.
authors: S
authors: S
authors: Sauro
authors: Private Practice, Ancona, Italy.
authors: A B
authors: AB
authors: D'Angelo
authors: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy c.rubini@univpm.it.
authors: C
authors: C
authors: Rubini
authors: Department of Biomedical Sciences and Public Health, Section of Pathologic Anatomy and Histopathology, Polytechnic University of Marche, Torrette, Ancona, Italy Private Practice, Pesaro, Italy.
authors: S D
authors: SD
authors: Aspriello
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000628:therapy; D063566:Biodegradable Plastics / Q000737:chemistry*; D001861:Bone Regeneration / Q000187:drug effects*; D017886:Durapatite / Q000008:administration & dosage* / Q000737:chemistry*; D005260:Female; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D008297:Male; D010316:Particle Size; D011100:Polyglycolic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016733:Rubber Dams; D012907:Smoking / Q000009:adverse effects*
chemical_list: D063566:Biodegradable Plastics; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite
keywords: barrier; biocomposite poly (lactic-co-glycolic) acid/submicron size hydroxyapatite; bone resorption; guided tissue regeneration; osseous defect