title: [Experience in the treatment of autoimmune male infertility in patients with category 4 chronic prostatitis].
abstract: Administration of longidaza at a dose of 3000 IU intramuscularly twice a week after 1 month of treatment leads to the statistically significant reduction of antisperm antibodies (ASAB) at the surface of sperm cells to 23% (7-48%) for MARIgG and to 14.5% (3-34%) for MARIgA. Maximum reduction of ASAB, however, was observed after third month of treatment, mean MARIgG was 2% (1-26,5%) and MARIgA - 1% (0-11.5%). ASAB level has not reduced less than 50% only in one patient (1.67%). At follow-up three months after the cancellation of Longidaza, only 17 (28.33%) men showed an increase of ASAB IgG and (or) IgA more than 50%. Inthe study group, during the observation, spontaneous pregnancy occurred in 6 (10%) pairs, and IVF was successfully performed in 3 (5%) pairs. Thus, we consider it necessary to appoint Longidaza in patients with category 4 chronic prostatitis and elevated levels of antisperm antibodies on sperm cells, who preparing for assisted reproductive technologies, or preparing for natural pregnancy, as a high-effective pathogenetical agent for the treatment of autoimmune infertility.
authors: D G
authors: DG
authors: Pochernikov
authors: E Iu
authors: EIu
authors: Vinokurov
authors: A I
authors: AI
authors: Strel'nikov
authors: L V
authors: LV
authors: Iakovleva
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D002908:Chronic Disease; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D007074:Immunoglobulin G / Q000276:immunology; D007248:Infertility, Male / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008297:Male; D011108:Polymers / Q000008:administration & dosage*; D011247:Pregnancy; D011472:Prostatitis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D012720:Severity of Illness Index; D013094:Spermatozoa / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D011108:Polymers; D006821:Hyaluronoglucosaminidase; C000597018:Longidaza