title: [Pharmacovigilance update].
abstract: The main pharmacovigilance updates in 2014 are reviewed. Ivabradine: increased risk of cardiovascular death and myocardial infarction in patients with symptomatic angina treated with high dosages. Clopidogrel: rare observations of acquired hemophilia. Orlistat: may reduce the absorption of HIV antiretrovirals. Ponatinib: increased risk of arteriopathy and thrombosis. Axitinib: significant risk of heart failure (class effect). Tocilizumab: possible causal relationship with the emergence or aggravation of psoriasis. Lithium: hypercalcemia and hyperparathyroidism commonly observed. Sildenalfil: suspected causal association with melanoma, so far not proven, Methylphenidate: rare observations of priapism. St John's wort (Hypericum): reduced effectiveness of hormonal contraceptives, including implants.
authors: Nathalie
authors: N
authors: Fogarasi Szabo
authors: Léonore
authors: L
authors: Diezi
authors: Laurie
authors: L
authors: Delenclos
authors: Delphine
authors: D
authors: Renard
authors: Haithem
authors: H
authors: Chtioui
authors: Laura E
authors: LE
authors: Rothuizen
authors: Thierry
authors: T
authors: Buclin
authors: Françoise
authors: F
authors: Livio
mesh_terms: D006801:Humans; D060735:Pharmacovigilance