title: Mannose-6-phosphate receptor: a target for theranostics of prostate cancer.
abstract: The development of personalized and non-invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over-expression of a membrane lectin, the cation-independent mannose 6-phosphate receptor (M6PR), was specifically demonstrated in prostate cancer cell lines and tissues. To efficiently target this lectin a mannose-6-phosphate analogue was synthesized in six steps and grafted onto the surface of functionalized mesoporous silica nanoparticles (MSNs). These MSNs were used for in vitro and ex vivo photodynamic therapy to treat prostate cancer cell lines and primary cell cultures prepared from patient biopsies. The results demonstrated the efficiency of M6PR targeting for prostate cancer theranostic.
authors: Institut des Biomolécules Max Mousseron, UMR 5247 CNRS, UM 1, UM 2-Faculté de Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier cedex 05 (France).
authors: Ophélie
authors: O
authors: Vaillant
authors: Khaled
authors: K
authors: El Cheikh
authors: David
authors: D
authors: Warther
authors: David
authors: D
authors: Brevet
authors: Marie
authors: M
authors: Maynadier
authors: Elise
authors: E
authors: Bouffard
authors: Frédéric
authors: F
authors: Salgues
authors: Audrey
authors: A
authors: Jeanjean
authors: Pierre
authors: P
authors: Puche
authors: Catherine
authors: C
authors: Mazerolles
authors: Philippe
authors: P
authors: Maillard
authors: Olivier
authors: O
authors: Mongin
authors: Mireille
authors: M
authors: Blanchard-Desce
authors: Laurence
authors: L
authors: Raehm
authors: Xavier
authors: X
authors: Rébillard
authors: Jean-Olivier
authors: JO
authors: Durand
authors: Magali
authors: M
authors: Gary-Bobo
authors: Alain
authors: A
authors: Morère
authors: Marcel
authors: M
authors: Garcia
mesh_terms: D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors* / Q000235:genetics; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D008360:Mannosephosphates / Q000138:chemical synthesis / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D010316:Particle Size; D010778:Photochemotherapy; D016062:Porosity; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D017527:Receptor, IGF Type 2 / Q000037:antagonists & inhibitors* / Q000235:genetics; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties
chemical_list: D014408:Biomarkers, Tumor; D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; C027693:mannose-6-phosphate; D012822:Silicon Dioxide
keywords: cancer; carbohydrates; nanoparticles; receptors; synthesis design