title: [Direct human DNA damage by unfavorable environmental and climatic factors].
abstract: OBJECTIVE
  To study the impact of simulated climatic conditions of the 2010 summer in Moscow on the telomere repeats of chromosomes in human blood cells.
  
  
  METHODS
  The climatic conditions of July-August 2010 in Moscow were simulated at the Medical Technical Complex, Institute of Biomedical Problems, Russian Academy of Sciences. The relative length of the telomeric repeats of blood cell chromosomes from 6 apparently healthy volunteers was measured by quantitative real-time polymerase chain reaction.
  
  
  RESULTS
  These conditions were ascertained to lead to a statistically significant decline in the length of telomere repeats in the terminal portions of chromosomes by 15%.
  
  
  CONCLUSIONS
  Environmental changes and abnormal temperature rises may result in oxidative stress accompanied by telomere shortening, which can be, in turn, a factor of premature aging.
authors: N A
authors: NA
authors: Doroshtuk
authors: A Iu
authors: AIu
authors: Postnov
authors: A D
authors: AD
authors: Doroshtuk
authors: E B
authors: EB
authors: Khasanova
authors: N V
authors: NV
authors: Konovalova
authors: Iu D
authors: IuD
authors: Khesuani
authors: M K
authors: MK
authors: Osiaeva
authors: O V
authors: OV
authors: Rodnenkov
authors: I E
authors: IE
authors: Chazova
mesh_terms: D000328:Adult; D000375:Aging / Q000378:metabolism; D002248:Carbon Monoxide / Q000009:adverse effects; D004249:DNA Damage / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009031:Moscow; D018384:Oxidative Stress / Q000502:physiology*; D016615:Telomere / Q000378:metabolism*; D013696:Temperature; D014887:Weather; D055815:Young Adult
chemical_list: D002248:Carbon Monoxide