title: Dioxygenation of cysteamine to hypotaurine at a tris(pyrazolyl)borate iron(ii) unit - cysteamine dioxygenase mimicking?
abstract: A novel complex Tp(Me,Ph)Fe(SCH2CH2NH2) has been synthesized as a speculative model for ADO. Indeed its reaction with O2 led to the dioxygenation of the S atom and thus to hypotaurine. This finding may allow us to draw conclusions on the constitution of the ADO active site, whose structure is still unknown.
authors: Department of Chemistry, Humboldt-Universität zu Berlin, Brook-Taylor-Str. 2, 12489 Berlin, Germany. christian.limberg@chemie.hu-berlin.de.
authors: M
authors: M
authors: Sallmann
authors: B
authors: B
authors: Braun
authors: C
authors: C
authors: Limberg
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D001881:Borates / Q000737:chemistry; D003543:Cysteamine / Q000737:chemistry*; D049308:Dioxygenases / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry; D013654:Taurine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D001881:Borates; D009942:Organometallic Compounds; D011720:Pyrazoles; C555951:tris(pyrazolyl)borate; D013654:Taurine; C003949:hypotaurine; D003543:Cysteamine; D007501:Iron; D049308:Dioxygenases; C019966:cysteamine dioxygenase; D010100:Oxygen