title: RNA-stabilizing proteins as molecular targets in cardiovascular pathologies.
abstract: The stability of mRNA has emerged as a key step in the regulation of eukaryotic gene expression and function. RNA stabilizing proteins (RSPs) contain several RNA recognition motifs, and selectively bind to adenylate-uridylate-rich elements in the 3' untranslated region of several mRNAs leading to altered processing, stability, and translation. These post-transcriptional gene regulations play a critical role in cellular homeostasis; therefore act as molecular switch between 'normal cell' and 'disease state.' Many mRNA binding proteins have been discovered to date, which either stabilize (HuR/HuA, HuB, HuC, HuD) or destabilize (AUF1, tristetraprolin, KSRP) the target transcripts. Although the function of RSPs has been widely studied in cancer biology, its role in cardiovascular pathologies is only beginning to evolve. The current review provides an overall understanding of the potential role of RSPs, specifically HuR-mediated mRNA stability in myocardial infarction, hypertension and hypertrophy. Also, the effect of RSPs on various cellular processes including inflammation, fibrosis, angiogenesis, cell-death, and proliferation and its relevance to cardiovascular pathophysiological processes is presented. We also discuss the potential clinical implications of RSPs as therapeutic targets in cardiovascular diseases.
authors: Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX.
authors: Sahana
authors: S
authors: Suresh Babu
authors: Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX.
authors: Darukeshwara
authors: D
authors: Joladarashi
authors: Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX.
authors: Prince
authors: P
authors: Jeyabal
authors: Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX.
authors: Rajarajan A
authors: RA
authors: Thandavarayan
authors: Department of Cardiovascular Sciences, Center for Cardiovascular Regeneration, Houston Methodist Research Institute, Houston, TX. Electronic address: pkrishnamurthy@houstonmethodist.org.
authors: Prasanna
authors: P
authors: Krishnamurthy
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000503:physiopathology*; D016923:Cell Death / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D000067780:ELAV-Like Protein 1 / Q000187:drug effects / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic / Q000235:genetics; D020871:RNA Stability / Q000235:genetics*; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D012680:Sensitivity and Specificity
chemical_list: D002317:Cardiovascular Agents; D000067780:ELAV-Like Protein 1; D012333:RNA, Messenger