title: GSH- and pH-responsive drug delivery system constructed by water-soluble pillar[5]arene and lysine derivative for controllable drug release.
abstract: Novel GSH- and pH-responsive supramolecular vesicles constructed by an amphiphilic inclusion complex formed from water-soluble pillar[5]arene and lysine derivative have been successfully developed, which can efficiently encapsulate anticancer drug MTZ and show rapid MTZ-release in a simulated acidic tumor environment with high GSH concentration, and exhibit potent antitumor activity.
authors: Key Laboratory of Mesoscopic Chemistry of MOE, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China. lywang@nju.edu.cn.
authors: Xuan
authors: X
authors: Wu
authors: Yan
authors: Y
authors: Li
authors: Chen
authors: C
authors: Lin
authors: Xiao-Yu
authors: XY
authors: Hu
authors: Leyong
authors: L
authors: Wang
mesh_terms: D047250:Calixarenes; D003692:Delayed-Action Preparations; D004220:Disulfides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D065546:Drug Liberation; D005978:Glutathione / Q000378:metabolism*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000737:chemistry*; D008942:Mitoxantrone / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004220:Disulfides; D004337:Drug Carriers; D000644:Quaternary Ammonium Compounds; C570642:pillar(5)arene; D014867:Water; D047250:Calixarenes; D008942:Mitoxantrone; D005978:Glutathione; D008239:Lysine