title: Curcumin mitigates accelerated aging after irradiation in Drosophila by reducing oxidative stress.
abstract: Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 μM) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γH2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γH2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.
authors: National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Ki Moon
authors: 0000-0003-3530-5587
authors: KM
authors: Seong
authors: Department of Biological Sciences, Inha University, 100 Inha Street, Incheon 402-751, Republic of Korea.
authors: Mira
authors: M
authors: Yu
authors: Bionanotechnology Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea.
authors: Kyu-Sun
authors: 0000-0002-4529-5186
authors: KS
authors: Lee
authors: National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Sunhoo
authors: S
authors: Park
authors: National Radiation Emergency Medical Center, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
authors: Young Woo
authors: YW
authors: Jin
authors: Department of Biological Sciences, Inha University, 100 Inha Street, Incheon 402-751, Republic of Korea.
authors: Kyung-Jin
authors: KJ
authors: Min
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D003474:Curcumin / Q000494:pharmacology*; D004249:DNA Damage; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D005720:Gamma Rays; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D010641:Phenotype; D050050:Protein Carbonylation / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D014921:Wings, Animal / Q000187:drug effects / Q000528:radiation effects
chemical_list: D029721:Drosophila Proteins; D017382:Reactive Oxygen Species; D003474:Curcumin