title: Deregulated expression of Aurora kinases is not a prognostic biomarker in papillary thyroid cancer patients.
abstract: A number of reports indicated that Aurora-A or Aurora-B overexpression represented a negative prognostic factor in several human malignancies. In thyroid cancer tissues a deregulated expression of Aurora kinases has been also demonstrated, but no information regarding its possible prognostic role in differentiated thyroid cancer is available. Here, we evaluated Aurora-A and Aurora-B mRNA expression and its prognostic relevance in a series of 87 papillary thyroid cancers (PTC), with a median follow-up of 63 months. The analysis of Aurora-A and Aurora-B mRNA levels in PTC tissues, compared to normal matched tissues, revealed that their expression was either up- or down-regulated in the majority of cancer tissues. In particular, Aurora-A and Aurora-B mRNA levels were altered, respectively, in 55 (63.2%) and 79 (90.8%) out of the 87 PTC analyzed.A significant positive correlation between Aurora-A and Aurora-B mRNAs was observed (p=0.001). The expression of both Aurora genes was not affected by the BRAFV600E mutation. Univariate, multivariate and Kaplan-Mayer analyses documented the lack of association between Aurora-A or Aurora-B expression and clinicopathological parameters such as gender, age, tumor size, histology, TNM stage, lymph node metastasis and BRAF status as well as disease recurrences or disease-free interval. Only Aurora-B mRNA was significantly higher in T(3-4) tissues, with respect to T(1-2) PTC tissues. The data reported here demonstrate that the expression of Aurora kinases is deregulated in the majority of PTC tissues, likely contributing to PTC progression. However, differently from other human solid cancers, detection of Aurora-A or Aurora-B mRNAs is not a prognostic biomarker in PTC patients.
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Enke
authors: E
authors: Baldini
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Chiara
authors: C
authors: Tuccilli
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Natalie
authors: N
authors: Prinzi
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Salvatore
authors: S
authors: Sorrenti
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Laura
authors: L
authors: Falvo
authors: Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.
authors: Corrado
authors: C
authors: De Vito
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Antonio
authors: A
authors: Catania
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Francesco
authors: F
authors: Tartaglia
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Renzo
authors: R
authors: Mocini
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Carmela
authors: C
authors: Coccaro
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Stefania
authors: S
authors: Alessandrini
authors: Department of Medicine, University of Padua, Padua, Italy.
authors: Susi
authors: S
authors: Barollo
authors: Department of Medicine, University of Padua, Padua, Italy.
authors: Caterina
authors: C
authors: Mian
authors: Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
authors: Alessandro
authors: A
authors: Antonelli
authors: Department of Surgical Sciences, "Sapienza" University of Rome, Rome, Italy.
authors: Enrico
authors: E
authors: De Antoni
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Massimino
authors: M
authors: D'Armiento
authors: Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
authors: Salvatore
authors: S
authors: Ulisse
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D064096:Aurora Kinase A / Q000235:genetics / Q000378:metabolism*; D064107:Aurora Kinase B / Q000235:genetics / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D051381:Rats; D013964:Thyroid Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D064096:Aurora Kinase A; D064107:Aurora Kinase B; D048493:Proto-Oncogene Proteins B-raf