title: [Position paper on the theoretical basis, practical application and health economic evaluation of the functional assessment of coronary lesions endorsed by the Italian Society of Invasive Cardiology (SICI-GISE)].
abstract: Functional assessment of coronary lesions has become an integral part of routine practice in most cath labs. Such evaluation is performed using a pressure wire that allows measurement of fractional flow reserve (FFR). The latter has received a class I indication with level of evidence A according to the most recent European guidelines on myocardial revascularization for the assessment of angiographically moderate coronary lesions. The present document has the following objectives: 1) to summarize the theoretical basis of FFR; 2) to provide a guideline for vasodilator therapy; 3) to summarize scientific evidence supporting FFR; 4) to provide a model of health economy evaluation focusing on resource sparing associated with the use of FFR.
authors: Francesco
authors: F
authors: Bedogni
authors: Ciro
authors: C
authors: Indolfi
authors: Flavio
authors: F
authors: Ribichini
authors: Edoardo
authors: E
authors: Verna
authors: Antonio Maria
authors: AM
authors: Leone
authors: Alberto
authors: A
authors: Polimeni
authors: Mario
authors: M
authors: Bollati
authors: Giuseppe
authors: G
authors: Biondi-Zoccai
authors: Luca
authors: L
authors: Testa
authors: Sergio
authors: S
authors: Berti
mesh_terms: D000255:Adenosine Triphosphate; D006328:Cardiac Catheterization / Q000191:economics / Q000379:methods / Q000592:standards; D002986:Clinical Trials as Topic; D003097:Collateral Circulation; D003326:Coronary Circulation; D023921:Coronary Stenosis / Q000175:diagnosis / Q000503:physiopathology; D003971:Diastole; D019317:Evidence-Based Medicine; D053805:Fractional Flow Reserve, Myocardial; D006334:Heart Function Tests / Q000191:economics / Q000379:methods / Q000592:standards; D006439:Hemodynamics; D006801:Humans; D007558:Italy; D015337:Multicenter Studies as Topic; D009200:Myocardial Contraction; D009599:Nitroprusside; D010208:Papaverine; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D000255:Adenosine Triphosphate; D010208:Papaverine