title: Proteomics studies in inner ear disorders: pathophysiology and biomarkers.
abstract: Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are underused due to technical challenges and/or complex features of the disease. Thus, in the past few years, healthcare and scientific agencies have advocated the development and adoption of proteomic technologies in otological research. However, few studies have been conducted and limited literature is available in this area. Here, we present the state of the art of proteomics in otology, discussing the substantial evidence from recent experimental models and clinical studies in inner-ear conditions. We also delineate a series of critical issues including minute size of the inner ear, delicacy and poor accessibility of tissue that researchers face while undertaking otology proteomics research. Furthermore, we provide perspective to enhance the impact and lead to the clinical implementation of these proteomics-based strategies.
authors: Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.
authors: Ali
authors: A
authors: Alawieh
authors: Stefania
authors: S
authors: Mondello
authors: Firas
authors: F
authors: Kobeissy
authors: Kamel
authors: K
authors: Shibbani
authors: Marc
authors: M
authors: Bassim
mesh_terms: D000818:Animals; D015415:Biomarkers; D007758:Ear, Inner / Q000254:growth & development / Q000503:physiopathology*; D006801:Humans; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D040901:Proteomics
chemical_list: D015415:Biomarkers; D011506:Proteins
keywords: biomarkers; hearing loss; inner ear; proteome; proteomics