title: Clinical outcomes of prospectively treated 140 women with early stage breast cancer using accelerated partial breast irradiation with 3 dimensional computerized tomography based brachytherapy.
abstract: OBJECTIVE
  To study the clinical outcomes of women with early breast cancer (EBC) treated with accelerated partial breast irradiation (APBI) with multicatheter interstitial brachytherapy (MIB) using 3 dimensional computerized tomography (3DCT) based planning.
  
  
  METHODS
  During August 2005 to January 2013, 140 women with EBC were treated prospectively with APBI using high dose rate (HDR) MIB. After 3DCT based planning patients were treated to a dose of 34 Gy/10 #/1 week with bid regimen.
  
  
  RESULTS
  Median age was 57 years and tumor size 2 cm (range: 0.6-3.2 cm). Infiltrating duct carcinoma (IDC) was the most common histology; grade III tumors were seen in 82%. Median dose homogeneity index (DHI) was 0.76 (range: 0.49-0.85). The median coverage index (CI) of the cavity was 90% (61.4-100) and 80.5% (53.6-97.4) for planning target volume (PTV). Median follow up was 60 months (1-102 months). The 5 and 7 year local control rates (LC) were 97% and 92% respectively. Her2 positivity was the only prognostic factor which had an adverse impact on LC (p=0.01). Five and 7 year disease free survival (DFS) and overall survival (OAS) were 93%, 84%, 97.5% and 89% respectively. Good to excellent cosmetic outcomes at last follow up were seen in 87 (77%) women.
  
  
  CONCLUSIONS
  3DCT based MIB results in excellent long term outcomes and good to excellent cosmesis. Her2 positivity has an adverse impact on LC rates.
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India. Electronic address: ashwininb@yahoo.com.
authors: Ashwini
authors: A
authors: Budrukkar
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Lavanya
authors: L
authors: Gurram
authors: Department of Medical Physics, Tata Memorial Hospital, Mumbai, India.
authors: Ritu Raj
authors: RR
authors: Upreti
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Anusheel
authors: A
authors: Munshi
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Rakesh
authors: R
authors: Jalali
authors: Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Rajendra
authors: R
authors: Badwe
authors: Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Vani
authors: V
authors: Parmar
authors: Department of Pathology, Tata Memorial Hospital, Mumbai, India.
authors: Tanuja
authors: T
authors: Shet
authors: Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Sudeep
authors: S
authors: Gupta
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Tabassum
authors: T
authors: Wadasadawala
authors: Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
authors: Rajiv
authors: R
authors: Sarin
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging / Q000532:radiotherapy; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: 3D planning; Accelerated partial breast irradiation; Interstitial brachytherapy