title: Guillain-Barré syndrome associated with Mycobacterium bovis lymphadenitis.
abstract: Guillain-Barré syndrome (GBS) is an autoimmune disease that can be triggered by different infectious agents. Here we report the case of a 26-year-old Algerian woman who developed GBS associated with a Mycobacterium bovis cervical lymphadenitis. Following intravenous immunoglobulin therapy, the patient's neurologic state returned to normal after 3 months. The lymphadenitis responded more slowly to the antituberculous treatment and an excision of necrotic cervical lymph nodes had to be performed four times. Antibiotics were administered for 16 months: ethambutol was stopped after 2 months, and rifampicin and isoniazid pursued for 14 months. An extensive etiological investigation showed that, in this case, the only likely infectious trigger GBS was the concomitant M. bovis infection. To our knowledge, this is the first report of GBS triggered by M. bovis. We performed a literature review revealing that the association between tuberculosis and Guillain-Barré syndrome is very rare (only seven cases previously reported) but is not coincidental. Physicians should be aware that tuberculosis can be a cause of GBS.
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France. delphine.vergnon@hotmail.fr.
authors: Delphine
authors: D
authors: Vergnon-Miszczycha
authors: MIIT Médical, Villeurbanne, France.
authors: Florence
authors: F
authors: Suy
authors: Service de Neurologie, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Florence
authors: F
authors: Robert
authors: Laboratoire de Bactériologie-Virologie, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Anne
authors: A
authors: Carricajo
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Anne
authors: A
authors: Fresard
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Céline
authors: C
authors: Cazorla
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Claire
authors: C
authors: Guglielminotti
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France.
authors: Frédéric
authors: F
authors: Lucht
authors: Service des Maladies Infectieuses et Tropicales, Centre Hospitalo-Universitaire Nord, 42055, Saint-Etienne Cedex 2, France. elisabeth.botelho-nevers@chu-st-etienne.fr.
authors: Elisabeth
authors: E
authors: Botelho-Nevers
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D003646:Debridement; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009163:Mycobacterium bovis / Q000302:isolation & purification*; D014388:Tuberculosis, Lymph Node / Q000150:complications*
chemical_list: D000995:Antitubercular Agents; D016756:Immunoglobulins, Intravenous
keywords: Autoimmunity; Guillain-Barré syndrome; Mycobacterium bovis; Tuberculosis