title: [Role of the Sonic Hedgehog pathway in thoracic cancers].
abstract: BACKGROUND
  Sonic Hedgehog (Shh) pathway is physiologically activated during embryogenesis and development. It plays a role in idiopathic lung fibrosis and is also activated in several solid cancers.
  
  
  BACKGROUND
  Shh pathway is reactivated in thoracic cancers, as small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma. Shh pathway is associated with cancer stem cells and seems to have a crucial role in tumor proliferation, aggressiveness and chemoresistance in these cancers. This review describes the activation mode of Shh pathway in thoracic cancers and its role in small cell lung carcinoma, non-small cell lung carcinoma and malignant pleural mesothelioma, using in vitro and in vivo models. Notably, data from literature show that inhibition of Shh pathway has an antitumor action and sensitizes to chemotherapy.
  
  
  CONCLUSIONS
  These results incite to develop targeted therapies against Shh pathway in the treatment of thoracic cancers.
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; EA4340 BCOH, service de pneumologie et oncologie thoracique, hôpital Ambroise-Paré, AP-HP, université Versailles-Saint-Quentin-en-Yvelines, 92100 Boulogne-Billancourt, France.
authors: E
authors: E
authors: Giroux Leprieur
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France.
authors: M
authors: M
authors: Antoine
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; Service de pneumologie et de réanimation, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris, France.
authors: T
authors: T
authors: Vieira
authors: Service de pneumologie et de réanimation, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris, France.
authors: N
authors: N
authors: Rozensztajn
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; Service de pneumologie et de réanimation, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris, France.
authors: A-M
authors: AM
authors: Ruppert
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France.
authors: N
authors: N
authors: Rabbe
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; Service de pneumologie et de réanimation, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris, France.
authors: J
authors: J
authors: Cadranel
authors: Sorbonne universités, UPMC université Paris 06, GRC n(o) 04, Theranoscan, 75252 Paris, France; Service de pneumologie et de réanimation, hôpital Tenon, AP-HP, 4, rue de la Chine, 75970 Paris, France. Electronic address: marie.wislez@tnn.aphp.fr.
authors: M
authors: M
authors: Wislez
mesh_terms: D000818:Animals; D001980:Bronchi / Q000196:embryology / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000503:physiopathology; D018288:Carcinoma, Small Cell / Q000503:physiopathology; D047108:Embryonic Development; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D025461:Feedback, Physiological; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D053823:Hedgehog Proteins / Q000502:physiology*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000503:physiopathology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D008168:Lung / Q000196:embryology / Q000473:pathology; D008175:Lung Neoplasms / Q000503:physiopathology; D008654:Mesothelioma / Q000503:physiopathology; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000502:physiology; D000072079:Patched Receptors; D010446:Peptide Fragments / Q000502:physiology; D010997:Pleural Neoplasms / Q000503:physiopathology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013899:Thoracic Neoplasms / Q000503:physiopathology*
chemical_list: D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D000072079:Patched Receptors; D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C509239:SHH protein, human
keywords: Cancer bronchique non à petites cellules; Cancer bronchique à petites cellules; Chemoresistance; Chimiorésistance; Mesothelioma; Mésothéliome; Non-small cell lung carcinoma; Small cell lung carcinoma; Sonic Hedgehog