title: The microbiota in inflammatory bowel disease.
abstract: This review explores our current understanding of the complex interaction between environmental risk factors, genetic traits and the development of inflammatory bowel disease. The primacy of environmental risk factors is illustrated by the rapid increase in the incidence of the disease worldwide. We discuss how the gut microbiota is the proximate environmental risk factor for subsequent development of inflammatory bowel disease. The evolving fields of virome and mycobiome studies will further our understanding of the full potential of the gut microbiota in disease pathogenesis. Manipulating the gut microbiota is a promising therapeutic avenue.
authors: Department of Medicine, University College Cork, National University of Ireland, Cork, Ireland, donalsheehan@me.com.
authors: Donal
authors: D
authors: Sheehan
authors: Carthage
authors: C
authors: Moran
authors: Fergus
authors: F
authors: Shanahan
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015992:Body Mass Index; D019317:Evidence-Based Medicine; D000069467:Fecal Microbiota Transplantation / Q000379:methods; D000069196:Gastrointestinal Microbiome; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology* / Q000628:therapy*; D008019:Life Style; D064307:Microbiota; D015995:Prevalence; D019936:Probiotics / Q000627:therapeutic use; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents