title: Topical use of autologous platelet rich plasma in myringoplasty.
abstract: OBJECTIVE
  The aim of this study was to assess the topical use of autologous platelet rich plasma (PRP) to improve success rate of myringoplasty.
  
  
  METHODS
  This study was carried out on 64 patients with large dry central tympanic membrane perforations. Myringoplasty was performed through postauricular approach by underlay graft using conchal perichondrial graft. Patients were classified into two groups: case group included 32 patients who had undergone myringoplasty with use of autologous PRP and control group included 32 patients who had undergone myringoplasty without use of autologous PRP.
  
  
  RESULTS
  Both groups were statistically matched with regard to age and sex. At 6 months postoperatively, success rate (graft taking) in case group (100%) was significantly higher than in control group (81.25%) (P=0.02). Success in terms of hearing gain (≥10dB) was achieved in 21 patients (65.6%) in case group and 11 patients (34.4%) in control group with statistically non-significant difference (P=0.079). Infection rate in control group (12.5%) was found to be significantly higher than in case group (P<0.0001).
  
  
  CONCLUSIONS
  Topical autologous PRP application during myringoplasty is safe and highly efficient and successful with no reported complication. PRP not only enhances healing of chronic TM perforations but also avoids infection and obviates the need for inner EAC pack.
authors: Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Egypt. Electronic address: mwenteg@yahoo.com.
authors: Mohammad Waheed
authors: MW
authors: El-Anwar
authors: Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Egypt.
authors: Magdy Abdalla Sayed
authors: MA
authors: El-Ahl
authors: Clinical Pathology Department, Faculty of Medicine, Zagazig University, Egypt.
authors: Amal Ahmad
authors: AA
authors: Zidan
authors: Otorhinolaryngology, Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Egypt.
authors: Mohammad Abdel-Rhman Abdel-Salam
authors: MA
authors: Yacoup
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D004425:Ear Cartilage / Q000637:transplantation*; D005260:Female; D006320:Hearing Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D009225:Myringoplasty / Q000379:methods*; D010035:Otitis Media, Suppurative / Q000150:complications / Q000628:therapy*; D053657:Platelet-Rich Plasma; D016896:Treatment Outcome; D018058:Tympanic Membrane Perforation / Q000209:etiology / Q000628:therapy*; D014945:Wound Healing; D055815:Young Adult
keywords: Myringoplasty; Platelet rich plasma; Tympanic membrane