title: Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine.
abstract: Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis of red oak infusions. Quercus infusions were prepared and administered as the sole source of drink to male Sprague-Dawley rats (1% w/v) for the entire 26-week experimental period. On week 4, rats received 8 subcutaneous injections of DMH (21 mg/kg body weight) once a week. The results showed that mean tumor (0.9 ± 0.2 vs. 2.6 ± 0.3) and multiplicity (1.2 ± 0.1 vs. 2.0 ± 0.23), and β-catenin protein level (2.2-fold) in adenocarcinomas were significantly lower in Quercus  sideroxyla-treated group compared with DMH group. By contrast, Quercus  durifolia and Quercus  eduardii infusions had no protective effect. Additionally, the experiments in HT-29 cells confirmed that Q. sideroxyla infusion effectively decreased the levels of the inflammatory markers COX-2 and IL-8 by modulating the expression of NF-κB. These results highlight some of the molecular mechanisms related to the chemopreventive effect of Q. sideroxyla infusion and its potential value as a source of bioactive compounds.
authors: Departamento de Ings. Química y Bioquímica, Instituto Tecnológico de Durango, Blvd. Felipe Pescador 1830 Ote., Col. Nueva Vizcaya, 34080 Durango, Dgo., Mexico.
authors: Martha Rocío
authors: MR
authors: Moreno-Jimenez
authors: Posgrado en Alimentos (PROPAC), Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas, S/N, Col. Centro, 76010 Querétaro, Qro., Mexico.
authors: Fátima
authors: F
authors: Trujillo-Esquivel
authors: Laboratorio de Histoptología, Facultad de Medicina, Universidad Autónoma de Querétaro, Clavel 200, Col. Prados de la Capilla, 76017 Querétaro, Qro., Mexico.
authors: Marco A
authors: MA
authors: Gallegos-Corona
authors: Posgrado en Alimentos (PROPAC), Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas, S/N, Col. Centro, 76010 Querétaro, Qro., Mexico.
authors: Rosalia
authors: R
authors: Reynoso-Camacho
authors: Departamento de Ings. Química y Bioquímica, Instituto Tecnológico de Durango, Blvd. Felipe Pescador 1830 Ote., Col. Nueva Vizcaya, 34080 Durango, Dgo., Mexico.
authors: Rubén Francisco
authors: RF
authors: González-Laredo
authors: Departamento de Ings. Química y Bioquímica, Instituto Tecnológico de Durango, Blvd. Felipe Pescador 1830 Ote., Col. Nueva Vizcaya, 34080 Durango, Dgo., Mexico.
authors: José Alberto
authors: JA
authors: Gallegos-Infante
authors: Departamento de Ings. Química y Bioquímica, Instituto Tecnológico de Durango, Blvd. Felipe Pescador 1830 Ote., Col. Nueva Vizcaya, 34080 Durango, Dgo., Mexico.
authors: Nuria Elizabeth
authors: NE
authors: Rocha-Guzmán
authors: Posgrado en Alimentos (PROPAC), Facultad de Química, Universidad Autónoma de Querétaro, Cerro de las Campanas, S/N, Col. Centro, 76010 Querétaro, Qro., Mexico. Electronic address: ramosgomezm@yahoo.com.
authors: Minerva
authors: M
authors: Ramos-Gomez
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000633:toxicity*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D015415:Biomarkers; D002470:Cell Survival; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D019073:HT29 Cells; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D029963:Quercus / Q000737:chemistry* / Q000145:classification; D051381:Rats; D013045:Species Specificity
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D015415:Biomarkers; D010936:Plant Extracts; D019813:1,2-Dimethylhydrazine
keywords: Anti-inflammatory; Anticarcinogenic activity; Colon cancer; Herbal infusions; Polyphenols; Quercus sideroxyla