title: [Recent advances in MR imaging for cancer diagnosis].
abstract: The recent development in magnetic resonance(MR)hardware and techniques allows the acquisition of functional information, such as perfusion or metabolism, in addition to conventional anatomical information in of cancers.In this review article, various molecular imaging methods based on MR are introduced and their application and usefulness for diagnosis of cancer are discussed.Diffusion weighted image (DWI) is believed to correlate cell density and reflect malignancy of tumor. DWI has been widely used for the diagnosis and evaluation of responses to cancer treatment.Arterial spin labeling (ASL) allows acquisition of perfusion data without the use of any contrast agent and is expected to be an alternative or complementary method to dynamic contrast enhanced MR imaging.Amide proton transfer (APT) imaging reflects the amount of mobile peptide and proteins in cancer tissue, and could be a useful tool for assessing tumor malignancy or evaluating treatment responses.More specific measurement of cancer metabolites is available at the cost of spatial resolution by MR spectroscopy (MRS). Finally, the positron emission tomography (PET)/MR hybrid system enables simultaneous acquisition of functional/ anatomical information from MR imaging and molecular/metabolic information from PET imaging.Combining various molecular MR imaging methods with PET tracers may have a huge potential for clinical diagnosis of cancer.
authors: Dept. of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University.
authors: Koji
authors: K
authors: Sagiyama
authors: Yuji
authors: Y
authors: Watanabe
authors: Akihiro
authors: A
authors: Nishie
authors: Ryotaro
authors: R
authors: Kamei
authors: Osamu
authors: O
authors: Togao
authors: Akio
authors: A
authors: Hiwatashi
authors: Satoshi
authors: S
authors: Kawanami
authors: Hiroshi
authors: H
authors: Honda
mesh_terms: D006801:Humans; D008279:Magnetic Resonance Imaging; D064847:Multimodal Imaging; D009369:Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed