title: Water proton NMR-a sensitive probe for solute association.
abstract: It is found that the transverse relaxation rate R2 of the water protons can be used to quantify protein aggregation and surfactant micellization in water. The simplicity and high intensity of the water proton signal enables non-invasive chemical analysis not readily achievable through solute proton signals, such as inspecting finished biologic products.
authors: Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA. byu@rx.umaryland.edu.
authors: Yue
authors: Y
authors: Feng
authors: Marc B
authors: MB
authors: Taraban
authors: Yihua Bruce
authors: YB
authors: Yu
mesh_terms: D000818:Animals; D002417:Cattle; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D066329:Protein Aggregates; D011522:Protons; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry*; D005719:gamma-Globulins / Q000737:chemistry*
chemical_list: D066329:Protein Aggregates; D011522:Protons; D012996:Solutions; D005719:gamma-Globulins; D014867:Water; D012710:Serum Albumin, Bovine