title: Anxiety in Huntington's Disease.
abstract: Anxiety is common in Huntington's disease (HD), though it has been under-researched. The authors conducted a systematic review of anxiety in HD. The prevalence of anxiety in manifest HD ranged from 13% to 71%. No significant difference in anxiety between manifest and premanifest HD carriers was revealed. Anxiety appears to be associated with depression, suicide, irritability, quality of life (QoL), pain, illness beliefs, and coping styles but does not seem to be linked with measures of disease progression. From the few pilot studies available, interventions that show promise include olanzapine and psychosocial approaches. Improved assessment, more exploration of the nature of anxiety in HD, and evaluation of anxiety interventions are required.
authors: From the Leicestershire Partnership NHS Trust Huntington's Disease Service, Adult Mental Health Clinical Psychology Department, OSL House, East Link, Meridian Business Park, Leicester, United Kingdom (MD); and the Department of Psychiatry, Leiden University Medical Centre, Leiden, Netherlands (EVD).
authors: Maria
authors: M
authors: Dale
authors: From the Leicestershire Partnership NHS Trust Huntington's Disease Service, Adult Mental Health Clinical Psychology Department, OSL House, East Link, Meridian Business Park, Leicester, United Kingdom (MD); and the Department of Psychiatry, Leiden University Medical Centre, Leiden, Netherlands (EVD).
authors: Erik
authors: E
authors: van Duijn
mesh_terms: D000223:Adaptation, Psychological; D001007:Anxiety / Q000150:complications* / Q000523:psychology; D001008:Anxiety Disorders / Q000150:complications* / Q000523:psychology; D018450:Disease Progression; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000523:psychology; D011788:Quality of Life / Q000523:psychology*