title: Adjunctive Valproic Acid in Management-Refractory Hyperactive Delirium: A Case Series and Rationale.
abstract: Patients with delirium may fail to respond to standard therapies. Sixteen patients with management-refractory hyperactive delirium responded to adjunctive valproic acid, with complete resolution of hyperactive delirium in 13 cases. A rationale for using valproic acid in such circumstances is discussed.
authors: From the Stanford University School of Medicine, Stanford, CA (YS, AA, JRM); and the George Washington University, Washington, DC (ACM, SL).
authors: Yelizaveta
authors: Y
authors: Sher
authors: From the Stanford University School of Medicine, Stanford, CA (YS, AA, JRM); and the George Washington University, Washington, DC (ACM, SL).
authors: Anne Catherine
authors: AC
authors: Miller
authors: From the Stanford University School of Medicine, Stanford, CA (YS, AA, JRM); and the George Washington University, Washington, DC (ACM, SL).
authors: Sermsak
authors: S
authors: Lolak
authors: From the Stanford University School of Medicine, Stanford, CA (YS, AA, JRM); and the George Washington University, Washington, DC (ACM, SL).
authors: Andrea
authors: A
authors: Ament
authors: From the Stanford University School of Medicine, Stanford, CA (YS, AA, JRM); and the George Washington University, Washington, DC (ACM, SL).
authors: José R
authors: JR
authors: Maldonado
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018692:Antimanic Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D003693:Delirium / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use*
chemical_list: D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D014635:Valproic Acid