title: Facile synthesis of gold nanorods/hydrogels core/shell nanospheres for pH and near-infrared-light induced release of 5-fluorouracil and chemo-photothermal therapy.
abstract: We described a facile synthesis of pH and near-infrared (NIR) light dual-sensitive core/shell hybrid nanospheres, consisting of gold nanorods (GNR) as the core and poly(N-isopropylacrylamide-co-methacrylic acid) as the shell, p(NIPAM-MAA). The resultant GNR/p(NIPAM-MAA) nanospheres showed a core/shell structure, with an average diameter of ∼110nm and a strong longitudinal surface plasmon band at NIR region. Due to the photothermal effect of GNR and pH/thermal-sensitive volume transition of p(NIPAM-MAA) hydrogels, the nanospheres with loading of 5-fluorouracil (5-FU) by electrostatic interactions were developed as a smart carrier for pH- and photothermal-induced release of 5-FU. Experimental results testified that the cumulative release of 5-FU from nanospheres was markedly increased in a mild acidic medium. Moreover, a NIR light (808nm) irradiation triggered a greater and faster release of 5-FU, which was further testified by relevant results from in vitro cytotoxicity assay, in vivo tumor growth inhibition and histological images of ex vivo tumor sections. These results revealed significant applications of GNR/p(NIPAM-MAA) nanospheres in controlled release of anticancer agents and photothermal ablation therapy of tumor tissues, accompanied by synergistic effect of chem-photothermal therapy.
authors: College of Chemical Science and Engineering, Collaborative Innovation Center for Marine Biomass Fiber, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, The State Key Laboratory Growing Base of Fiber Materials and Modern Textiles, Qingdao University, Shandong 266071, PR China.
authors: Hui
authors: H
authors: Jin
authors: Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.
authors: Xifeng
authors: X
authors: Liu
authors: College of Chemical Science and Engineering, Collaborative Innovation Center for Marine Biomass Fiber, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, The State Key Laboratory Growing Base of Fiber Materials and Modern Textiles, Qingdao University, Shandong 266071, PR China. Electronic address: guirijun@qdu.edu.cn.
authors: Rijun
authors: R
authors: Gui
authors: College of Chemical Science and Engineering, Collaborative Innovation Center for Marine Biomass Fiber, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, The State Key Laboratory Growing Base of Fiber Materials and Modern Textiles, Qingdao University, Shandong 266071, PR China. Electronic address: wangzonghua@qdu.edu.cn.
authors: Zonghua
authors: Z
authors: Wang
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004339:Drug Compounding; D005260:Female; D005347:Fibroblasts; D005472:Fluorouracil / Q000737:chemistry / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced / Q000379:methods; D007259:Infrared Rays; D061986:MCF-7 Cells; D051379:Mice; D008819:Mice, Nude; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011109:Polymethacrylic Acids / Q000737:chemistry*; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000178:Acrylamides; D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C085085:poly(N-isopropylacrylamide-co-methacrylic acid); D006046:Gold; D005472:Fluorouracil
keywords: 5-Fluorouracil; Drug release; Gold nanorods; Nanospheres; Photothermal effect