title: Baseline platelet indices and bleeding after transcatheter aortic valve implantation.
abstract: Bleeding complications are frequent and independently predict mortality after transcatheter aortic valve implantation (TAVI). It has been demonstrated that certain platelet parameters are indicative of platelet reactivity. We sought to determine the possible correlation between simple platelet indices and bleeding complications in patients undergoing TAVI. Platelet indices--platelet count, mean platelet volume (MPV), platelet distribution width and plateletcrit--were measured in 110 consecutive patients on the day preceding TAVI. In-hospital bleeding events after TAVI were assessed according to the Valve Academic Research Consortium-2 classification as any bleeding, major and life-threatening bleeding (MLTB) and need for transfusion. By receiver-operating characteristic analysis, only MPV was able to distinguish between patients with and without any bleeding [area under the curve (AUC) 0.629, 95% confidence interval (CI) 0.531-0.719, P = 0.0342], MLTB (AUC 0.730, 95% CI 0.637-0.811, P = 0.0004) and need for transfusion (AUC 0.660, 95% CI 0.563-0.747, P = 0.0045). By multivariate logistic regression, high MPV (>10.6) and low platelet distribution width (<14.8) were associated with increased risk of any bleeding [odds ratio (OR) 4.08, 95% CI 1.66-10.07, P = 0.0022; and OR 3.82, 95% CI 1.41-10.36, P = 0.0084, respectively] and MLTB (OR 10.76, 95% CI 3.05-38, P = 0.0002; and OR 8.46, 95% CI 1.69-42.17, P = 0.0092, respectively). Additionally, high MPV independently correlated with the need for transfusion (OR 4.11, 95% CI 1.71-9.86, P = 0.0016). Larger and less heterogenic platelets may be associated with increased risk of short-term bleeding complications after TAVI.
authors: a1st Department of Cardiology bDepartment of Cardiosurgery c2nd Department of Anesthesiology and Intensive Therapy, Medical University of Warsaw, Warsaw, Poland.
authors: Zenon
authors: Z
authors: Huczek
authors: Janusz
authors: J
authors: Kochman
authors: Michal Krzysztof
authors: MK
authors: Kowara
authors: Radoslaw
authors: R
authors: Wilimski
authors: Piotr
authors: P
authors: Scislo
authors: Anna
authors: A
authors: Scibisz
authors: Bartosz
authors: B
authors: Rymuza
authors: Renata
authors: R
authors: Andrzejewska
authors: Paulina
authors: P
authors: Stanecka
authors: Krzysztof J
authors: KJ
authors: Filipiak
authors: Grzegorz
authors: G
authors: Opolski
mesh_terms: D001024:Aortic Valve Stenosis / Q000628:therapy*; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D065467:Transcatheter Aortic Valve Replacement; D016896:Treatment Outcome