title: Complementary hydrogen bonding interaction triggered co-assembly of an amphiphilic peptide and an anti-tumor drug.
abstract: We report a new tumor-targeting amphiphilic peptide that can form complementary hydrogen bonds with anti-tumor drug methotrexate (MTX), leading to reversible self-assembled morphology transition from loose micelles to densely packed nanorods or nanofibers. The MTX loaded nanorods can target tumor cells and show more than 2-fold higher cytotoxicity (IC50 = 0.38 mg L(-1)) than that towards normal cells (IC50 = 0.89 mg L(-1)).
authors: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. xd-xu@whu.edu.cn xz-zhang@whu.edu.cn.
authors: Hong
authors: H
authors: Cheng
authors: Yin-Jia
authors: YJ
authors: Cheng
authors: Sushant
authors: S
authors: Bhasin
authors: Jing-Yi
authors: JY
authors: Zhu
authors: Xiao-Ding
authors: XD
authors: Xu
authors: Ren-Xi
authors: RX
authors: Zhuo
authors: Xian-Zheng
authors: XZ
authors: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry*; D019556:COS Cells; D002522:Chlorocebus aethiops; D006367:HeLa Cells; D006801:Humans; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D008727:Methotrexate / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D057139:Nanofibers / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D008727:Methotrexate