title: Effect of Fluoxetine on Periodontal Status in Patients With Depression: A Cross-Sectional Observational Study.
abstract: BACKGROUND
  Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to reduce periodontal disease severity in a rat ligature-induced periodontitis model. The objective of the present study is to investigate the influence of fluoxetine intake on periodontal parameters in patients with periodontitis with clinical depression.
  
  
  METHODS
  A sample of 236 patients with chronic periodontitis and clinical depression were assessed for clinical parameters of periodontal disease. Of these, 115 patients were taking fluoxetine (20 mg/day) for ≥2 months, and 121 patients were not. Participants taking fluoxetine were further analyzed for correlation between duration of drug intake and periodontal parameters.
  
  
  RESULTS
  All periodontal parameters, except plaque index, were significantly lower in participants taking fluoxetine (P <0.01). Partial correlation analysis, adjusted for confounders, revealed a significant and negative correlation between duration of fluoxetine intake and attachment loss (AL) (R(2) = -0.321, P <0.05). Logistic regression analysis revealed that fluoxetine intake was associated with a lower risk of having AL ≥3 (odds ratio [OR] = 0.55, 95% confidence interval [CI] = 0.31 to 0.96) and lower odds of increased bleeding on probing (BOP) percentage values (OR = 0.62, 95% CI = 0.34 to 0.97).
  
  
  CONCLUSIONS
  In this observational study, use of fluoxetine was associated with lower BOP percentages and reduced AL.
authors: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors: Anu
authors: A
authors: Bhatia
authors: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors: Rajinder K
authors: RK
authors: Sharma
authors: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors: Shikha
authors: S
authors: Tewari
authors: Department of Psychiatry, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
authors: Hitesh
authors: H
authors: Khurana
authors: Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors: Satish C
authors: SC
authors: Narula
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D055113:Chronic Periodontitis / Q000145:classification; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D003863:Depression / Q000188:drug therapy*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Anti-inflammatory agents; cross-sectional studies; fluoxetine; inflammation; periodontitis