title: APOE ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons.
abstract: The authors compared the risk for subjective cognitive impairment (SCI) between carriers of the apolipoprotein E ε4 (APOE ε4) allele (cases) and APOE ε4 noncarriers (controls). SCI was assessed by a validated self-reported questionnaire. The authors used multivariable logistic regression analyses to compute odds ratios and 95% confidence intervals adjusted for age, sex, education, and marital status. Data were available on 114 participants (83 women; 47 APOE ε4 carriers; mean age, 69 years). The risk for SCI was significantly higher among cases than controls, particularly for those 70 years of age and older. These findings should be considered preliminary until confirmed by a prospective cohort study.
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Janina
authors: J
authors: Krell-Roesch
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Bryan K
authors: BK
authors: Woodruff
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Jazmin I
authors: JI
authors: Acosta
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Dona E
authors: DE
authors: Locke
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Joseph G
authors: JG
authors: Hentz
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Cynthia M
authors: CM
authors: Stonnington
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Gorazd B
authors: GB
authors: Stokin
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Chelsea
authors: C
authors: Nagle
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Bernard F
authors: BF
authors: Michel
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Nathalie
authors: N
authors: Sambuchi
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Richard J
authors: RJ
authors: Caselli
authors: From the Mayo Clinic, Scottsdale, AZ (JK-R, BKW, JIA, DEL, JGH, CMS, CN, RJC, YEG); International Clinical Research Center and St. Anne's University Hospital, Brno, Czech Republic (JK-R, GBS, YEG); and Hôpital Sainte-Marguerite, Marseille, France (BFM, NS).
authors: Yonas E
authors: YE
authors: Geda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D055815:Young Adult
chemical_list: D001057:Apolipoproteins E