title: New cytotoxic lignan glycosides from Phyllanthus glaucus.
abstract: During the process of exploring bioactive lead compounds from Phyllanthus species, two new glycosides including an arylnaphthalene lignan, diphyllin 4-O-α-L-arabinopyranosyl-(1 → 3)-α-L-arabinopyranoside (1), and a phenolic compound, 3,4,5-trimethoxybenzyl alcohol 7-O-α-L-arabinofuranosyl-(1 → 6)-β-D-glucopyranoside (2), were isolated from the methanol extract of the whole plants of Phyllanthus glaucus Wall. ex Müll. Arg. In addition, 31 known compounds, including 19 lignan derivatives (3-21), four phenylpropanoids (22-25), seven simple phenolics (26-32) and one monoterpenoid (33) were obtained. Their structures were determined on the basis of the HR-ESI-MS, 1D and 2D NMR spectroscopic analysis, and pre-column derivative/chiral HPLC analysis in case of 1 for the absolute configurations. All these compounds were obtained from P. glaucus for the first time. Moreover, the known lignan glycoside, phyllanthusmin C (5) showed in vitro cytotoxicities against HL-60, MCF-7 and SW480 cells with IC50 values of 9.2 ± 0.2, 19.2 ± 1.7 and 20.5 ± 0.9, respectively.
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.|b University of Chinese Academy of Sciences , Beijing 100049 , People's Republic of China.
authors: Shan
authors: S
authors: Yu
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Jun-Jiang
authors: JJ
authors: Lv
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Jian-Qiang
authors: JQ
authors: Zhao
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Yan
authors: Y
authors: Li
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Dong
authors: D
authors: Wang
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Chong-Ren
authors: CR
authors: Yang
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Min
authors: M
authors: Xu
authors: a State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Lanhei Road 132#, Kunming 650201 , People's Republic of China.
authors: Ying-Jun
authors: YJ
authors: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D052117:Benzodioxoles; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004187:Disaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D029803:Phyllanthus / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000610628:3,4,5-trimethoxybenzyl alcohol 7-O-alpha-L-arabinofuranosyl-(1-6)-beta-D-glucopyranoside; C000610629:4-O-alpha-L-arabinopyranosyl-(1-3)-alpha-L-arabinopyranoside; D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D004187:Disaccharides; D006027:Glycosides; D017705:Lignans; D039821:Monoterpenes; D010636:Phenols; D010936:Plant Extracts; C010130:diphyllin
keywords: Phyllanthus glaucus Wall. ex Müll. Arg; arylnaphthalene lignan; cytotoxicity; glycoside; phenolics