title: Structural chromosomal aberrations as potential risk markers in incident cancer patients.
abstract: Epidemiological prospective studies have shown that increased chromosomal aberrations (CAs) in peripheral blood lymphocytes may predict cancer risk. Here, we report CAs in newly diagnosed 101 colorectal, 87 lung and 158 breast cancer patients and corresponding healthy controls. Strong differences in distributions of aberrant cells (ACs), CAs, chromatid-type aberrations (CTAs) and chromosome-type aberrations (CSAs) were observed in lung and breast cancer patients as compared to healthy controls. In colorectal cancer (CRC) patients, only CTAs were significantly elevated. Binary logistic regression, adjusted for main confounders, indicates that all the analysed cytogenetic parameters along with smoking were significantly associated with breast and lung cancer risks. Significant differences in terminal deletions between breast cancer patients and corresponding female controls were recorded (0.39 vs. 0.18; P ≤ 0.05). We did not find any association of CAs with TNM (tumor nodus metastasis) stages or histopathological grade in either cancer type. CAs were neither associated with additional tumor characteristics-invasivity, ductal and lobular character, estrogene/progesterone receptors in breast tumors nor with non-small/small cell and bronchogenic/pulmonary types of lung tumors. Our study demonstrates that CAs serve as a predictive marker for breast and lung cancer, whereas only CTAs were elevated in incident CRC patients.
authors: Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic, Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic.
authors: Sona
authors: S
authors: Vodenkova
authors: Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic.
authors: Zdenka
authors: Z
authors: Polivkova
authors: Clinic of Occupational Medicine and Toxicology, Jessenius Faculty of Medicine, Comenius University and University Hospital, 036 01 Martin, Slovakia.
authors: Ludovit
authors: L
authors: Musak
authors: Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic, 2nd Faculty of Medicine, Charles University in Prague, 150 06 Prague, Czech Republic.
authors: Zdenek
authors: Z
authors: Smerhovsky
authors: Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic.
authors: Hana
authors: H
authors: Zoubkova
authors: Department of General Biology and Genetics, 3rd Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic.
authors: Sylvie
authors: S
authors: Sytarova
authors: Clinic of Pneumology and Phthisiology, Jessenius Faculty of Medicine, Comenius University and University Hospital, 036 59 Martin, Slovakia.
authors: Elena
authors: E
authors: Kavcova
authors: Institute of Medical Biology, Jessenius Faculty of Medicine, Comenius University and University Hospital, 038 61 Martin, Slovakia.
authors: Erika
authors: E
authors: Halasova
authors: Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic, Biomedical Centre, Faculty of Medicine in Pilsen, Charles University in Prague, 323 00 Pilsen, Czech Republic.
authors: Ludmila
authors: L
authors: Vodickova
authors: Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic.
authors: Katerina
authors: K
authors: Jiraskova
authors: Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic.
authors: Miroslav
authors: M
authors: Svoboda
authors: Department of Radiology and Oncology, Faculty Hospital Kralovske Vinohrady, 100 42 Prague, Czech Republic.
authors: Miloslav
authors: M
authors: Ambrus
authors: Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), 691 20 Heidelberg, Germany.
authors: Kari
authors: K
authors: Hemminki
authors: Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic, Institute of Biology and Medical Genetics, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague, Czech Republic, pvodicka@biomed.cas.cz.
authors: Pavel
authors: P
authors: Vodicka
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor