title: A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs.
abstract: A conveniently amplified DNA AND logic gate platform was designed for the highly sensitive detection of low-abundance DNA fragment inputs based on strand displacement reaction and rolling circle amplification strategy. Compared with others, this system can detect miRNAs in biological samples. The success of this strategy demonstrates the potential of DNA logic gates in disease diagnosis.
authors: College of Chemistry and Molecular Sciences, Institute of Advanced Studies, Wuhan University, Wuhan, Hubei 430072, P. R. China. xzhou@whu.edu.cn.
authors: Yuqi
authors: Y
authors: Chen
authors: Yanyan
authors: Y
authors: Song
authors: Fan
authors: F
authors: Wu
authors: Wenting
authors: W
authors: Liu
authors: Boshi
authors: B
authors: Fu
authors: Bingkun
authors: B
authors: Feng
authors: Xiang
authors: X
authors: Zhou
mesh_terms: D039301:Computers, Molecular; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D006367:HeLa Cells; D006801:Humans; D057230:Limit of Detection; D008128:Logic; D035683:MicroRNAs / Q000032:analysis* / Q000235:genetics*; D021141:Nucleic Acid Amplification Techniques
chemical_list: D035683:MicroRNAs; D004247:DNA