title: Effects of various pharmacological agents on the function of norepinephrine transporter.
abstract: The norepinephrine transporter is selectively expressed in noradrenergic nerve terminals, where it can exert spatial and temporal control over the action of norepinephrine. The norepinephrine transporter mediates the termination of neurotransmission via the reuptake of norepinephrine released into the extracellular milieu. In the present brief review, we report our recent studies about the effects of various pharmacological agents such as fasudil, nicotine, pentazocine, ketamine and genistein on norepinephrine transporter function.
authors: Shared-Use Research Center, Facility for Education and Research Support, University of Occupational and Environmental Health, Japan.
authors: Noriaki
authors: N
authors: Satoh
authors: Yumiko
authors: Y
authors: Toyohira
authors: Keita
authors: K
authors: Takahashi
authors: Nobuyuki
authors: N
authors: Yanagihara
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000031:analogs & derivatives* / Q000494:pharmacology; D059331:Adrenergic Neurons / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000378:metabolism; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D009411:Nerve Endings / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D010423:Pentazocine / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000235:genetics
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; D005473:Fluoxetine; C011386:nisoxetine; D007649:Ketamine; D009538:Nicotine; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D019833:Genistein; C049347:fasudil; D010423:Pentazocine; D009638:Norepinephrine