title: [The role of lactate acidosis in the development and treatment of various neurologic syndromes in children and adolescents].
abstract: The aim of the study was to detect the role of lactate acidosis, also to find the share of mitochondrial insufficiency in development of various neurologic syndromes in children and adolescents. The detection of cellular energetic metabolism and acid based imbalance is also important for finding the specific method of management. We have studied 200 patients with various degree of neurodevelopment delay with epilepsy and epileptic syndromes, headache, vertigo, early strokes, floppy infant syndrome, atrophy of ophthalmic nerve, cataracta, neurosensory deafness, systemic myopathy, cerebral palsy. In 27% of cases with various ages we have detected lactate acidosis and increase level of pyruvate. Mitochondrial insufficiency was seen in 8% of cases which gives us opportunity to find the specific method of treatment in this group of patients. Each patient with neurological symptoms requires correction of parameters of energetic and oxidative metabolism.
authors: G A
authors: GA
authors: Arveladze
authors: N M
authors: NM
authors: Geladze
authors: T B
authors: TB
authors: Sanikidze
authors: N S
authors: NS
authors: Khachapuridze
authors: S Z
authors: SZ
authors: Bakhtadze
mesh_terms: D000138:Acidosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004734:Energy Metabolism; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000473:pathology; D009422:Nervous System Diseases / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D019344:Lactic Acid