title: Inflammation and prostate cancer: friends or foe?
abstract: BACKGROUND
  Prostate cancer is the most common non-cutaneous malignancy diagnosed in men. Moving from histological observations since a long time, it has been recognized that innate and adaptive immunity actively participates in the pathogenesis, surveillance, and progression of prostate cancer.
  
  
  METHODS
  A PubMed and Web of Science databases search was performed for studies providing evidence on the roles of the innate and adaptive immunity during the development and progression of prostate cancer.
  
  
  CONCLUSIONS
  There are growing evidences that chronic inflammation is involved in the regulation of cellular events in prostate carcinogenesis, including disruption of the immune response and regulation of the tumor microenvironment. This review discusses the role played by the innate and adaptive immune system in the local progression of prostate cancer, and the prognostic information that we can currently understand and exploit.
authors: Department of Urology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
authors: Gianluigi
authors: G
authors: Taverna
authors: Elisa
authors: E
authors: Pedretti
authors: Giuseppe
authors: G
authors: Di Caro
authors: Elena Monica
authors: EM
authors: Borroni
authors: Federica
authors: F
authors: Marchesi
authors: Fabio
authors: F
authors: Grizzi
mesh_terms: D056704:Adaptive Immunity; D018925:Chemokines / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D008297:Male; D011471:Prostatic Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D018925:Chemokines