title: Nicotine-induced ICAM-1 and VCAM-1 expression in mouse cardiac vascular endothelial cell via p38 MAPK signaling pathway.
abstract: OBJECTIVE
  To explore the link between cigarette smoking and thromboembolic events and to investigate cigarette smoking as a major risk factor in the etiology of atherosclerosis.
  
  
  METHODS
  We determined the effect of nicotine on the expression of adhesion molecules, intercellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) in mouse cardiac vascular endothelial cells and the involvement of important known intermediaries, namely p38 mitogen-activated protein kinase (MAPK) signaling pathway.
  
  
  RESULTS
  Our results indicate that nicotine can enhance the expression of ICAM-1 and VCAM-1 on mouse cardiac vascular endothelial cell via p38 MAPK signaling pathway, resulting in increased expression of the cellular adhesion molecules ICAM-1 and VCAM-1.
  
  
  CONCLUSIONS
  We demonstrate that 10(-6) M nicotine maximally enhances mouse cardiac vascular endothelial cell expression of ICAM-1 and VCAM-1 at 8 hours. Our results provide a putative mechanism by which nicotine stimulates expression of these adhesion molecules via p38 MAPK signaling pathway.
authors: Hong-Shan
authors: HS
authors: Yin
authors: Yong-Jun
authors: YJ
authors: Li
authors: Zhi-An
authors: ZA
authors: Jiang
authors: Su-Yun
authors: SY
authors: Liu
authors: Bing-Yan
authors: BY
authors: Guo
authors: Tao
authors: T
authors: Wang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics* / Q000473:pathology; D002460:Cell Line; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D009538:Nicotine / Q000494:pharmacology; D010766:Phosphorylation; D011655:Pulmonary Embolism / Q000235:genetics / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics; D012907:Smoking / Q000009:adverse effects; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis* / Q000235:genetics; D048051:p38 Mitogen-Activated Protein Kinases / Q000235:genetics*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D009538:Nicotine; D048051:p38 Mitogen-Activated Protein Kinases