title: Association of vitamin D deficiency with acute lower respiratory tract infections in newborns.
abstract: OBJECTIVE
  To determine the association between serum 25-hydroxy vitamin D [25(OH)D] levels and acute respiratory tract infections (ALRTI) in newborns.
  
  
  METHODS
  The study group consisted of 30 term newborns with ALRTI who were admitted to our neonatal intensive care unit. Controls were 30 healthy newborns with the same age as the study group. Newborns and their mothers were tested for serum 25(OH)D levels, with a low level defined as ≤15 ng/mL.
  
  
  RESULTS
  The groups were similar in gestational week, birthweight, postnatal age and gender. Forty-three of the 60 infants (including study and control) had low 25(OH)D levels. The median 25(OH)D levels were lower [9.5 ng/mL (IQR = 7.9-12.2)] in the study group than those of the control group [15.5 ng/mL (IQR: 12-18)] (p = 0.0001). The median serum 25(OH)D levels in the mothers of the study group were also lower than those in the mothers of the control group [11.6 ng/mL (IQR = 9.4-15.8) and 17.3 ng/mL (IQR = 13.7-20.6), respectively] (p = 0.0001).
  
  
  CONCLUSIONS
  Lower blood 25(OH)D levels might be associated with increased risk of ALRTI in term newborn babies. Appropriate vitamin D supplementation during pregnancy and early childhood may enhance newborns' respiratory health.
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Nurdan
authors: N
authors: Dinlen
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Aysegul
authors: A
authors: Zenciroglu
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Serdar
authors: S
authors: Beken
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Arzu
authors: A
authors: Dursun
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Dilek
authors: D
authors: Dilli
authors: a Division of Neonatology , Sami Ulus Maternity and Children's Education and Research Hospital , Ankara , Turkey.
authors: Nurullah
authors: N
authors: Okumus
mesh_terms: D000328:Adult; D019587:Dietary Supplements / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011014:Pneumonia / Q000097:blood / Q000209:etiology*; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25-Hydroxyvitamin D; acute lower respiratory infection; newborn; vitamin D deficiency