title: Methuselah regulates longevity via dTOR: a pathway revealed by small-molecule ligands.
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors: Junjie
authors: J
authors: Wang
authors: CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Zhilong
authors: Z
authors: Wang
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors: Zhenghong
authors: Z
authors: Zhang
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors: Qiuhong
authors: Q
authors: Hua
authors: CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors: Min
authors: M
authors: Wang
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors: Changjie
authors: C
authors: Shi
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
authors: Lei
authors: L
authors: Xue
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China xxie@simm.ac.cn ru.zhang@tongji.edu.cn.
authors: Ru
authors: R
authors: Zhang
authors: Shanghai Key Laboratory of Signaling and Disease Research, Laboratory of Receptor-based Bio-medicine, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China CAS Key Laboratory of Receptor Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China xxie@simm.ac.cn ru.zhang@tongji.edu.cn.
authors: Xin
authors: X
authors: Xie
mesh_terms: D000818:Animals; D004330:Drosophila / Q000201:enzymology; D029721:Drosophila Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic; D057809:HEK293 Cells; D006801:Humans; D008024:Ligands; D008136:Longevity; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction; D054852:Small Molecule Libraries / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D008024:Ligands; D043562:Receptors, G-Protein-Coupled; D054852:Small Molecule Libraries; C115381:mth protein, Drosophila; C416303:target of rapamycin protein, Drosophila; D058570:TOR Serine-Threonine Kinases