title: The role of transforming growth factor β1 in the regulation of blood pressure.
abstract: Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) β1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFβ1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFβ1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFβ signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFβ1 could influence blood pressure levels.
authors: Kota
authors: K
authors: Matsuki
authors: Catherine K
authors: CK
authors: Hathaway
authors: Marlon G
authors: MG
authors: Lawrence
authors: Oliver
authors: O
authors: Smithies
authors: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, CB #7525, 701 Brinkhous-Bullitt Building, Chapel Hill, NC 27599-7525, USA. mkakoki@med.unc.edu.
authors: Masao
authors: M
authors: Kakoki
mesh_terms: D000305:Adrenal Cortex Hormones / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D004573:Electrolytes / Q000652:urine; D019332:Endothelin-1 / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D010953:Plasma Volume / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000493:pharmacokinetics; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D000305:Adrenal Cortex Hormones; D004573:Electrolytes; D019332:Endothelin-1; D053773:Transforming Growth Factor beta1; D009569:Nitric Oxide; D012964:Sodium