title: The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
abstract: Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1β, IL-6, IL-8, VEGF-A, and PDGF-BB levels between two groups. There were positive significant correlations between MK and GSH, MK, and selenium levels in patients with MCTR. According to our data in which selenium, zinc, MK, and GSH decreased in MCTR patients, inflammatory response, oxidative stress, and trace element levels may contribute to etiopathogenesis of mitral regurgitation and/or ruptured chordae tendineae.
authors: Department of Biophysics, Faculty of Medicine, Sakarya University, 54290, Sakarya, Turkey, birsenay2001@yahoo.com.
authors: Birsen
authors: B
authors: Aydemir
authors: Ramazan
authors: R
authors: Akdemir
authors: M Bulent
authors: MB
authors: Vatan
authors: F Behice
authors: FB
authors: Cinemre
authors: Hakan
authors: H
authors: Cinemre
authors: Ali Riza
authors: AR
authors: Kiziler
authors: Nurten
authors: N
authors: Bahtiyar
authors: M Emin
authors: ME
authors: Buyukokuroglu
authors: Gonul
authors: G
authors: Gurol
authors: Selim
authors: S
authors: Ogut
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078792:Midkine; D008944:Mitral Valve Insufficiency / Q000097:blood*; D009414:Nerve Growth Factors / Q000097:blood*; D012422:Rupture, Spontaneous / Q000097:blood; D012643:Selenium / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D015032:Zinc / Q000097:blood*
chemical_list: D016207:Cytokines; C066254:MDK protein, human; D009414:Nerve Growth Factors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000078792:Midkine; D012643:Selenium; D015032:Zinc