title: Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis.
abstract: BACKGROUND
  The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis.
  
  
  METHODS
  Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5 mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions.
  
  
  RESULTS
  After salivary stimulation therapy, subjective symptom scores were significantly improved (p=0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), Tmin, and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy.
  
  
  CONCLUSIONS
  The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.
authors: 1 Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine , Incheon, Republic of Korea.
authors: Jeong-Seok
authors: JS
authors: Choi
authors: 2 Department of Internal Medicine, Inha University School of Medicine , Incheon, Republic of Korea.
authors: Seong Bin
authors: SB
authors: Hong
authors: 3 Department of Nuclear Medicine, Inha University School of Medicine , Incheon, Republic of Korea.
authors: In Young
authors: IY
authors: Hyun
authors: 1 Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine , Incheon, Republic of Korea.
authors: Jae-Yol
authors: JY
authors: Lim
authors: 1 Department of Otorhinolaryngology-Head and Neck Surgery, Inha University School of Medicine , Incheon, Republic of Korea.
authors: Young-Mo
authors: YM
authors: Kim
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000628:therapy*; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000628:therapy*; D002291:Carcinoma, Papillary; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000627:therapeutic use*; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D010862:Pilocarpine / Q000627:therapeutic use*; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000009:adverse effects; D018714:Radiotherapy, Adjuvant; D012469:Salivary Glands / Q000000981:diagnostic imaging*; D012793:Sialadenitis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000628:therapy*; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes; D018721:Muscarinic Agonists; D019275:Radiopharmaceuticals; D010862:Pilocarpine