title: Increased bone mineral density according to increase of skeletal muscle mass in 534 Korean women: A retrospective cohort study conducted over 2.7 years.
abstract: OBJECTIVE
  To determine the impact of the changes in the amount of abdominal fat, directly measured by computed tomography, body composition, and the metabolic syndrome (MetS) risk factors on the bone mineral density (BMD) of Korean women.
  
  
  METHODS
  A retrospective cohort study involving 534 Korean women aged 29 to 78 years, who had undergone both dual-energy X-ray absorptiometry and abdominal adipose tissue analysis by computed tomography scan more than twice between January 2004 and December 2010. The changes in the BMD values were examined in association with the changes in fat amount, body composition parameters, and risk factors of MetS.
  
  
  RESULTS
  On cross sectional analysis, there was a significant positive correlation between femoral BMD and total abdominal fat amount at the initial visit. However, the correlation disappeared when the impact of change of the fat amount on the change in BMD was analyzed over the study period. When the MetS and body composition parameters were analyzed, a significantly positive correlation was found between skeletal muscle mass and BMD. There was no significant relationship between the MetS risk factors or other body composition parameters and BMD throughout the study period after adjusting for age (time interval).
  
  
  CONCLUSIONS
  Among body composition parameters, only increased skeletal muscle mass had a positive correlation with increased BMD over the study period of 2.7 years.
authors: Seoul National University Hospital Health Care System Kangnam Center, Seoul, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Sun Mie
authors: SM
authors: Kim
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
authors: Seok Hyun
authors: SH
authors: Kim
authors: Seoul National University Hospital Health Care System Kangnam Center, Seoul, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Jin Ju
authors: JJ
authors: Kim
authors: Seoul National University Hospital Health Care System Kangnam Center, Seoul, Korea. ; Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
authors: Min-Jeong
authors: MJ
authors: Kim
authors: Seoul National University Hospital Health Care System Kangnam Center, Seoul, Korea.
authors: Hyuk Tae
authors: HT
authors: Kwon
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
authors: Chang Suk
authors: CS
authors: Suh
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
authors: Young Min
authors: YM
authors: Choi
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. ; Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Korea.
authors: Jung Gu
authors: JG
authors: Kim
keywords: Abdominal fat; Bone density; Metabolic syndrome; Skeletal muscle mass