title: Enhancement of Oral Bioavailability of Curcumin by a Novel Solid Dispersion System.
abstract: The objective of this study was to improve the solubility and bioavailability of curcumin by a new curcumin dripping pills (Cur-DPs) formulation using melt mixing methods. The optimal formulation consisted of Polyethoxylated 40 hydrogenated castor oil (Cremophor RH40), Poloxamer 188, and Polyethylene glycol 4000 (PEG 4000). Differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FT-IR) were used to verify the forming of Cur-DPs. All the physical characterization information proved the formation of Cur-DPs, and the results demonstrated the superiority of the dripping pills in dissolution rates. The pharmacokinetic study of Cur-DPs was performed in rats compared to the pure curcumin suspension. The oral bioavailability of poorly water-soluble curcumin was successfully improved by CUR-DPs. And the stability of prepared Cur-DP was also in a good state in 3 months. These results identified the Cur-DPs was an effective new approach for pharmaceutical application.
authors: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China. pharm126@126.com.|Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, People's Republic of China. pharm126@126.com.
authors: Liandong
authors: L
authors: Hu
authors: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.
authors: Yanjing
authors: Y
authors: Shi
authors: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.
authors: Jian Heng
authors: JH
authors: Li
authors: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.
authors: Na
authors: N
authors: Gao
authors: Department of Hematology, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
authors: Jing
authors: J
authors: Ji
authors: CSPC Pharmaceutical Group NBP Pharmaceutical Co. Ltd, Shijiazhuang, People's Republic of China.
authors: Feng
authors: F
authors: Niu
authors: Department of Surgical Oncology, Affiliated Hospital of Hebei University, Baoding, People's Republic of China.
authors: Queting
authors: Q
authors: Chen
authors: Tianjin Hemay Bio-Tech Co., Ltd, Tianjin, People's Republic of China.
authors: Xiaoning
authors: X
authors: Yang
authors: School of Pharmaceutical Sciences, Hebei University, No. 180, WuSi Road, Baoding, 071002, People's Republic of China.
authors: Shaocheng
authors: S
authors: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003474:Curcumin / Q000737:chemistry*; D008297:Male; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011208:Powders / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D011208:Powders; D014867:Water; D020442:Poloxamer; C022131:cremophor; D011092:Polyethylene Glycols; C000595214:polyethylene glycol 4000; D003474:Curcumin
keywords: curcumin; dripping pills; oral bioavailability; physicochemical properties; stability