title: A malignant transformation of a spinal epidural mass from ganglioneuroblastoma to neuroblastoma.
abstract: Ganglioneuromas are benign tumors. Surgical excision is the treatment of choice with very good prognosis. However, neuroblastomatous malignant transformation of ganglioneuromas was previously reported. We report a patient with spinal neuroblastoma recurrent from a ganglioneuroblastoma after disease free survival of 13 years. This is one of the rare examples of spinal neuroblastoma and to our knowledge the second case report with malignant transformation from a ganglioneuroblastoma or a ganglioneuroma. The present case is the only report in the literature with further genetic investigations.
authors: Department of Neurosurgery, School of Medicine, Istanbul University, Istanbul, Turkey.
authors: Mehmet Osman
authors: MO
authors: Akcakaya
authors: Department of Pathology, School of Medicine, Istanbul University, Istanbul, Turkey.
authors: Bilge
authors: B
authors: Bilgic
authors: Department of Neurosurgery, School of Medicine, Istanbul University, Istanbul, Turkey.
authors: Yavuz
authors: Y
authors: Aras
authors: Department of Neurosurgery, School of Medicine, Istanbul University, Istanbul, Turkey.
authors: Nail
authors: N
authors: Izgi
keywords: Ganglioneuroblastoma; Malignant transformation; Neuroblastoma; Spinal tumor