title: Association of MDM2 polymorphism with risk and prognosis of leukemia: a meta-analysis.
abstract: OBJECTIVE
  In this study, we performed an updated meta-analysis by summarizing all available relevant association studies to evaluate whether the murine double minute-2 (MDM2) T309G polymorphism is associated with risk of leukemia and to determine its prognostic effect.
  
  
  METHODS
  Studies published in PubMed, Embase and the Cochrane Controlled Trial Register were searched till June 2014 using the search terms 'MDM2', 'polymorphism' and 'leukemia'.
  
  
  RESULTS
  Eleven studies were included in this meta-analysis, with a total of 2,478 patients accrued. There were 8 studies providing data on single nucleotide polymorphism at position 309 (SNP309) and risk of leukemia and 7 studies providing data on SNP309 and overall survival. Our analysis showed that patients having G/G mutations had a significantly higher risk of developing leukemia (HR 1.90, 95% CI 1.56-2.31, p < 0.00001), while the association between G/T and leukemia was not significant (HR 1.18, 95% CI 0.96-1.45, p = 0.11). In addition, SNP309 was not significantly associated with patient survival (HR 1.29, 95% CI 0.79-2.13, p = 0.31).
  
  
  CONCLUSIONS
  Our meta-analysis showed that the MDM2 T309G variation, especially homozygous G/G, might be associated with an increased risk of leukemia. Additional studies are needed to confirm the findings as well as to understand the underlying mechanisms.
authors: Xuepeng
authors: X
authors: He
authors: Peng
authors: P
authors: Chen
authors: Kai
authors: K
authors: Yang
authors: Bing
authors: B
authors: Liu
authors: Yuan
authors: Y
authors: Zhang
authors: Fang
authors: F
authors: Wang
authors: Zhi
authors: Z
authors: Guo
authors: Xiaodong
authors: X
authors: Liu
authors: Jinxing
authors: J
authors: Lou
authors: Huiren
authors: H
authors: Chen
mesh_terms: D000483:Alleles; D016208:Databases, Factual; D004198:Disease Susceptibility; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D051736:Proto-Oncogene Proteins c-mdm2