title: Overview of xeroderma pigmentosum proteins architecture, mutations and post-translational modifications.
abstract: The xeroderma pigmentosum complementation group proteins (XPs), which include XPA through XPG, play a critical role in coordinating and promoting global genome and transcription-coupled nucleotide excision repair (GG-NER and TC-NER, respectively) pathways in eukaryotic cells. GG-NER and TC-NER are both required for the repair of bulky DNA lesions, such as those induced by UV radiation. Mutations in genes that encode XPs lead to the clinical condition xeroderma pigmentosum (XP). Although the roles of XPs in the GG-NER/TC-NER subpathways have been extensively studied, complete knowledge of their three-dimensional structure is only beginning to emerge. Hence, this review aims to summarize the current knowledge of mapped mutations and other structural information on XP proteins that influence their function and protein-protein interactions. We also review the possible post-translational modifications for each protein and the impact of these modifications on XP protein functions.
authors: Biotechnology Center of the Federal University of Rio Grande do Sul, Department of Molecular Biology and Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors: Bruno César
authors: BC
authors: Feltes
authors: Biotechnology Center of the Federal University of Rio Grande do Sul, Department of Molecular Biology and Biotechnology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: diegobonatto@gmail.com.
authors: Diego
authors: D
authors: Bonatto
mesh_terms: D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D021621:Imaging, Three-Dimensional; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D014983:Xeroderma Pigmentosum / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins
keywords: DNA repair; GG-NER; Post-translational modifications; Protein structure; TC-NER; Xeroderma pigmentosum