title: Acute treatment of cycloid psychosis: study on a sample of naive hospitalized patients with first-episode psychosis (FEP).
abstract: BACKGROUND
  In spite of the historic, clinical and therapeutic importance of cycloid psychosis, no controlled studies have been performed as yet on its treatment. Electroconvulsive therapy has classically been the treatment of choice and the first generation antipsychotics have not been indicated. This study has aimed to analyze the acute treatment (and response to it) of cycloid psychoses.
  
  
  METHODS
  In a sample of 75 hospitalized medication- naive patients treated for a First Psychotic Episode (FPE), possible cases of cycloid psychoses were detected using the Perris and Brockington operative diagnostic criteria. The sample was divided into &#8220;cycloids&#8221; and &#8220;non-cycloids&#8221; and both groups were compared based on clinical and therapeutic variables.
  
  
  RESULTS
  All the patients were treated with second generation antipsychotics. No significant differences (p=0.17; t-1.39) were found in the antipsychotic dose prescribed (equivalents of chlorpromazine). However, significant differences were observed in the improvement on hospital discharge (clinical global impression severity: CGI-S), with better response in the &#8220;cycloid&#8221; group&#8221; (p=0.002; u=162). Significant differences were also observed in the dose of benzodiazepines, there being significantly greater improvement for the &#8220;cycloid&#8221; group (p>0.001; u=28).
  
  
  CONCLUSIONS
  Without contradicting the classical idea of the treatment of cycloid psychoses, the present study contributes to the opening of a new therapeutic prospect. Thus, the use of second generation antipsychotics could have a particularly beneficial effect, especially if combined with high doses of benzodiazepines in the acute treatment of cycloid psychoses. However, controlled studies need to be carried out to confirm this.
authors: Instituto de Psiquiatría y Salud Mental. Hospital Clínico San Carlos Departamento de Psiquiatría. Universidad Computense de Madrid. Madrid. Spain.
authors: Rafael F
authors: RF
authors: García-Andrade
authors: Instituto de Psiquiatría y Salud Mental. Hospital Clínico San Carlos Departamento de Psiquiatría. Universidad Computense de Madrid. Madrid. Spain.
authors: Juan J
authors: JJ
authors: López-Ibor
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines