title: Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice.
abstract: Local tumor recurrence remains a major clinical problem following surgical treatment for most cancers such as hepatocellular carcinoma (HCC). An implantable local drug delivery system may be suitable for addressing this unmet clinical need. In this study, asymmetric multilayer polylactide nanofiber (AMPN) mats were prepared and a one-sided and prolonged release profile of hydrophilic dye or oxaliplatin was observed after they were sandwiched between two liver lobes in mice. Covering the surgery site by drug-loaded AMPN mat after tumor resection, in both subcutaneous and orthotopic HCC model in mice, the recurrence of HCC was significantly retarded and the survival time of mice was markedly prolonged. In conclusion, post-surgical therapy at tumor resection margins by drug-loaded AMPN mats may represent a suitable application of nanofiber-based local chemotherapy.
  
  
  BACKGROUND
  After cancer surgery, local recurrence remains a significant problem. In this study, the authors designed asymmetric multilayer PLA nanofiber (AMPN) mats and loaded them with anti-tumor drugs. Both in-vitro and in-vivo experiments showed good efficacy in preventing tumor recurrence. This novel product may point a way to the future and improve survival of cancer patients.
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China; The University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors: Shi
authors: S
authors: Liu
authors: Health Improving Department, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.
authors: Xue
authors: X
authors: Wang
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China; The University of Chinese Academy of Sciences, Beijing, People's Republic of China.
authors: Zhiyun
authors: Z
authors: Zhang
authors: The First Hospital of Jilin University, Changchun, People's Republic of China.
authors: Yan
authors: Y
authors: Zhang
authors: Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China. Electronic address: gyzhou@ciac.ac.cn.
authors: Guangyuan
authors: G
authors: Zhou
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China.
authors: Yubin
authors: Y
authors: Huang
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China. Electronic address: xiez@ciac.ac.cn.
authors: Zhigang
authors: Z
authors: Xie
authors: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People's Republic of China.
authors: Xiabin
authors: X
authors: Jing
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D008099:Liver / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D008297:Male; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D011091:Polyesters / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D011091:Polyesters; C033616:poly(lactide)
keywords: Cancer recurrence; Drug-loaded nanofiber mats; HCC treatment; Local therapy; One-sided drug release; Orthotopic liver model