title: PICan: An integromics framework for dynamic cancer biomarker discovery.
abstract: Modern cancer research on prognostic and predictive biomarkers demands the integration of established and emerging high-throughput technologies. However, these data are meaningless unless carefully integrated with patient clinical outcome and epidemiological information. Integrated datasets hold the key to discovering new biomarkers and therapeutic targets in cancer. We have developed a novel approach and set of methods for integrating and interrogating phenomic, genomic and clinical data sets to facilitate cancer biomarker discovery and patient stratification. Applied to a known paradigm, the biological and clinical relevance of TP53, PICan was able to recapitulate the known biomarker status and prognostic significance at a DNA, RNA and protein levels.
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Darragh G
authors: DG
authors: McArt
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Jaine K
authors: JK
authors: Blayney
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: David P
authors: DP
authors: Boyle
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Gareth W
authors: GW
authors: Irwin
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Michael
authors: M
authors: Moran
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Ryan A
authors: RA
authors: Hutchinson
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Peter
authors: P
authors: Bankhead
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Declan
authors: D
authors: Kieran
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Yinhai
authors: Y
authors: Wang
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Philip D
authors: PD
authors: Dunne
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Richard D
authors: RD
authors: Kennedy
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Paul B
authors: PB
authors: Mullan
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: D Paul
authors: DP
authors: Harkin
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Mark A
authors: MA
authors: Catherwood
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom.
authors: Jacqueline A
authors: JA
authors: James
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom. Electronic address: m.salto-tellez@qub.ac.uk.
authors: Manuel
authors: M
authors: Salto-Tellez
authors: Centre for Cancer Research and Cell Biology (CCRCB), Queen's University Belfast, Belfast, United Kingdom. Electronic address: p.hamilton@qub.ac.uk.
authors: Peter W
authors: PW
authors: Hamilton
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Biomarker discovery; Digital pathology; Pathology integromics