title: Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?
abstract: Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells (regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue.
authors: Ana I Flores, Gonzalo J Gómez-Gómez, Ángeles Masedo-González, M Pilar Martínez-Montiel, Servicio de Aparato Digestivo, Hospital 12 de Octubre, Avda. de Córdoba, 28041 Madrid, Spain.
authors: Ana I
authors: AI
authors: Flores
authors: Ana I Flores, Gonzalo J Gómez-Gómez, Ángeles Masedo-González, M Pilar Martínez-Montiel, Servicio de Aparato Digestivo, Hospital 12 de Octubre, Avda. de Córdoba, 28041 Madrid, Spain.
authors: Gonzalo J
authors: GJ
authors: Gómez-Gómez
authors: Ana I Flores, Gonzalo J Gómez-Gómez, Ángeles Masedo-González, M Pilar Martínez-Montiel, Servicio de Aparato Digestivo, Hospital 12 de Octubre, Avda. de Córdoba, 28041 Madrid, Spain.
authors: Ángeles
authors: Á
authors: Masedo-González
authors: Ana I Flores, Gonzalo J Gómez-Gómez, Ángeles Masedo-González, M Pilar Martínez-Montiel, Servicio de Aparato Digestivo, Hospital 12 de Octubre, Avda. de Córdoba, 28041 Madrid, Spain.
authors: M Pilar
authors: MP
authors: Martínez-Montiel
keywords: Amniotic fluid stem cells; Crohn’s disease; Endothelial progenitor cells; Hematopoietic stem cell; Induced pluripotent stem cells; Inflammatory bowel disease; Intestinal stem cells; Mesenchymal stem cell; Tolerogenic immune cell therapies; Ulcerative colitis