title: A Genome-Wide Chronological Study of Gene Expression and Two Histone Modifications, H3K4me3 and H3K9ac, during Developmental Leaf Senescence.
abstract: The genome-wide abundance of two histone modifications, H3K4me3 and H3K9ac (both associated with actively expressed genes), was monitored in Arabidopsis (Arabidopsis thaliana) leaves at different time points during developmental senescence along with expression in the form of RNA sequencing data. H3K9ac and H3K4me3 marks were highly convergent at all stages of leaf aging, but H3K4me3 marks covered nearly 2 times the gene area as H3K9ac marks. Genes with the greatest fold change in expression displayed the largest positively correlated percentage change in coverage for both marks. Most senescence up-regulated genes were premarked by H3K4me3 and H3K9ac but at levels below the whole-genome average, and for these genes, gene expression increased without a significant increase in either histone mark. However, for a subset of genes showing increased or decreased expression, the respective gain or loss of H3K4me3 marks was found to closely match the temporal changes in mRNA abundance; 22% of genes that increased expression during senescence showed accompanying changes in H3K4me3 modification, and they include numerous regulatory genes, which may act as primary response genes.
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.) judy.brusslan@csulb.edu.
authors: Judy A
authors: JA
authors: Brusslan
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.).
authors: Giancarlo
authors: G
authors: Bonora
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.).
authors: Ana M
authors: AM
authors: Rus-Canterbury
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.).
authors: Fayha
authors: F
authors: Tariq
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.).
authors: Artur
authors: A
authors: Jaroszewicz
authors: Department of Biological Sciences, California State University, Long Beach, California 90840-9502 (J.A.B., A.M.R.-C., F.T.); andDepartment of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095 (G.B., A.J., M.P.).
authors: Matteo
authors: M
authors: Pellegrini
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D001483:Base Sequence; D015870:Gene Expression; D018506:Gene Expression Regulation, Plant; D018745:Genome, Plant / Q000235:genetics*; D042421:Histone Code; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D008745:Methylation; D008969:Molecular Sequence Data; D018515:Plant Leaves / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D018749:RNA, Plant / Q000235:genetics / Q000378:metabolism; D017423:Sequence Analysis, RNA; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D006657:Histones; D018749:RNA, Plant