title: Effects of resveratrol treatment on bone and cartilage in obese diabetic mice.
abstract: BACKGROUND
  Resveratrol is a polyphenolic phytoalexin that has been shown to exhibit osteoprotective and chondroprotective properties. We examine the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice.
  
  
  METHODS
  Eight-week-old ob/ob and lean control mice were given trans-resveratrol at an oral dose of 25 mg/kg for 3 weeks. Histomorphometric and cross-sectional-geometric variables were analyzed.
  
  
  RESULTS
  Ob/ob mice in our study exhibit significantly reduced femoral length, resistance to loading, and tibial growth plate total area and calcified area than lean controls (P < 0.05). Resveratrol treatment significantly increased cortical area in both ob/ob and control mice, but did not improve cross-sectional indicators of resistance to bending. Resveratrol treatment also reduced tibial length and calcified growth plate cartilage area in comparison to untreated mice (P < 0.05).
  
  
  CONCLUSIONS
  Resveratrol treatment of ob/ob mice had mixed effects on bone histomorphometry at the femoral midshaft. Treatment increased cortical area but decreased bone length.
authors: Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ USA.
authors: Joseph
authors: J
authors: Cooley
authors: Departent of Physiology, Laboratory of Diabetes and Exercise Metabolism, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ USA.
authors: Tom L
authors: TL
authors: Broderick
authors: Departent of Physiology, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ USA.
authors: Layla
authors: L
authors: Al-Nakkash
authors: Department of Anatomy, Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ USA.
authors: Jeffrey H
authors: JH
authors: Plochocki
keywords: Cross-sectional geometry; Growth plate; Leptin; Resveratrol