title: Patient-reported symptoms and quality of life  in adults with acute leukemia: a systematic review.
abstract: OBJECTIVE
  Systematically summarize findings from research conducted on adult acute leukemia survivors as they relate to symptoms and quality of life (QOL).
  
  
  METHODS
  Systematic review of the literature from 1990–2013 found in the PubMed, PsycINFO®, EMBASE, and CINAHL® databases, as well as manual searches.
  
  
  RESULTS
  The review identified 16 quantitative studies and 1 qualitative study published from 1990–2013 that used a self-reported QOL or symptom questionnaire. Fatigue was the most commonly assessed and reported symptom, followed by depression.
  
  
  CONCLUSIONS
  Acute leukemia and its treatment have a significant impact in all QOL domains. Future studies should include longitudinal research, more than one recruitment site, increased minority representation, and home-based exercise interventions as ways to improve all domains of QOL.
  
  
  CONCLUSIONS
  This review increases awareness of commonly reported symptoms faced by adults with acute leukemia. Oncology nurses are central in monitoring and reporting symptoms to the interdisciplinary team that may contribute to changes in function, with the overall goal of optimizing QOL over time.
authors: School of Nursing, University of North Carolina, Chapel Hill, NC.
authors: Ashley
authors: A
authors: Leak Bryant
authors: College of Nursing, University of Utah, Salt Lake City, UT.
authors: AnnMarie
authors: A
authors: Lee Walton
authors: User Services in the Health Sciences Library, University of North Carolina, Chapel Hill, NC.
authors: Julia
authors: J
authors: Shaw-Kokot
authors: School of Nursing, University of North Carolina, Chapel Hill, NC.
authors: Deborah K
authors: DK
authors: Mayer
authors: Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
authors: Bryce B
authors: BB
authors: Reeve
mesh_terms: D000328:Adult; D000368:Aged; D016021:Epidemiologic Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000451:nursing / Q000523:psychology*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000451:nursing / Q000523:psychology*; D036301:Qualitative Research; D011788:Quality of Life; D012107:Research Design; D029181:Spirituality; D017741:Survivors / Q000523:psychology; D063189:Symptom Assessment
keywords: acute leukemia; acute leukemia survivors; patient-reported symptoms; quality of life; symptoms; systematic review