title: Analysis of the cytotoxicity of carbon-based nanoparticles, diamond and graphite, in human glioblastoma and hepatoma cell lines.
abstract: Nanoparticles have attracted a great deal of attention as carriers for drug delivery to cancer cells. However, reports on their potential cytotoxicity raise questions of their safety and this matter needs attentive consideration. In this paper, for the first time, the cytotoxic effects of two carbon based nanoparticles, diamond and graphite, on glioblastoma and hepatoma cells were compared. First, we confirmed previous results that diamond nanoparticles are practically nontoxic. Second, graphite nanoparticles exhibited a negative impact on glioblastoma, but not on hepatoma cells. The studied carbon nanoparticles could be a potentially useful tool for therapeutics delivery to the brain tissue with minimal side effects on the hepatocytes. Furthermore, we showed the influence of the nanoparticles on the stable, fluorescently labeled tumor cell lines and concluded that the labeled cells are suitable for drug cytotoxicity tests.
authors: Department of Hybrid Microbiosystem Engineering, Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.
authors: Karolina Ewa
authors: KE
authors: Zakrzewska
authors: Department of Hybrid Microbiosystem Engineering, Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.
authors: Anna
authors: A
authors: Samluk
authors: Division of Nanobiotechnology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.
authors: Mateusz
authors: M
authors: Wierzbicki
authors: Division of Nanobiotechnology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.
authors: Sławomir
authors: S
authors: Jaworski
authors: Division of Nanobiotechnology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.
authors: Marta
authors: M
authors: Kutwin
authors: Division of Nanobiotechnology, Faculty of Animal Science, Warsaw University of Life Sciences, Warsaw, Poland.
authors: Ewa
authors: E
authors: Sawosz
authors: Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: André
authors: A
authors: Chwalibog
authors: Department of Hybrid Microbiosystem Engineering, Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.
authors: Dorota Genowefa
authors: DG
authors: Pijanowska
authors: Department of Hybrid Microbiosystem Engineering, Nalecz Institute of Biocybernetics and Biomedical Engineering PAS, Warsaw, Poland.
authors: Krzysztof Dariusz
authors: KD
authors: Pluta
mesh_terms: D002244:Carbon / Q000008:administration & dosage / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D018130:Diamond / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D016503:Drug Delivery Systems / Q000009:adverse effects; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006108:Graphite / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D053758:Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D002244:Carbon; D018130:Diamond; D006108:Graphite