title: Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ.
abstract: The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific interactions with the protein are still unknown. Herein we report the synthesis of analogues that contain a more tractable core structure and an analogue with single-digit micromolar inhibition of FtsZ's GTPase activity, which represents the most potent inhibitor of Escherichia coli FtsZ reported to date. In addition, the zantrin Z3 core has been converted to two potential photo-cross-linking reagents for proteomic studies that could shed light on the molecular interactions between FtsZ and molecules related to zantrin Z3.
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Gabriella M
authors: GM
authors: Nepomuceno
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Katie M
authors: KM
authors: Chan
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Valerie
authors: V
authors: Huynh
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Kevin S
authors: KS
authors: Martin
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Jared T
authors: JT
authors: Moore
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Terrence E
authors: TE
authors: O'Brien
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Luiz A E
authors: LA
authors: Pollo
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Francisco J
authors: FJ
authors: Sarabia
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Clarissa
authors: C
authors: Tadeus
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Zi
authors: Z
authors: Yao
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: David E
authors: DE
authors: Anderson
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: James B
authors: JB
authors: Ames
authors: University of California, Davis , One Shields Avenue, Davis, California 95616, United States.
authors: Jared T
authors: JT
authors: Shaw
keywords: FtsZ; SAR; bacterial cell division; zantrin Z3