title: Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens' antibacterial susceptibility.
abstract: The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases and Japanese Society for Clinical Microbiology in 2010. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period from January and April 2010 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical and Laboratory Standard Institutes using maximum 45 antibacterial agents. Susceptibility testing was evaluable with 954 strains (206 Staphylococcus aureus, 189 Streptococcus pneumoniae, 4 Streptococcus pyogenes, 182 Haemophilus influenzae, 74 Moraxella catarrhalis, 139 Klebsiella pneumoniae and 160 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was as high as 50.5%, and those of penicillin-intermediate and -resistant S. pneumoniae were 1.1% and 0.0%, respectively. Among H. influenzae, 17.6% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant, 33.5% to be β-lactamase-non-producing ABPC-resistant and 11.0% to be β-lactamase-producing ABPC-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 2.9% and 0.6%, respectively. Continuous national surveillance of antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Nagasaki University School of Medicine, Nagasaki, Japan. Electronic address: karyo@jc4.so-net.ne.jp.
authors: Katsunori
authors: K
authors: Yanagihara
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Oita University Faculty of Medicine, Oita, Japan.
authors: Junichi
authors: J
authors: Kadota
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan; Shinrakuen Hospital, Niigata, Japan.
authors: Nobuki
authors: N
authors: Aoki
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Tetsuya
authors: T
authors: Matsumoto
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Masaki
authors: M
authors: Yoshida
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Morimasa
authors: M
authors: Yagisawa
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Toyoko
authors: T
authors: Oguri
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Junko
authors: J
authors: Sato
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Kazuhiko
authors: K
authors: Ogasawara
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Tomotaro
authors: T
authors: Wakamura
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Keisuke
authors: K
authors: Sunakawa
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Akira
authors: A
authors: Watanabe
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Satoshi
authors: S
authors: Iwata
authors: The Surveillance Committee of Japanese Society of Chemotherapy (JSC), The Japanese Association for Infectious Diseases (JAID) and The Japanese Society for Clinical Microbiology (JSCM), Tokyo, Japan.
authors: Mitsuo
authors: M
authors: Kaku
authors: The Kitasato Institute, Tokyo, Japan.
authors: Hideaki
authors: H
authors: Hanaki
authors: Asahikawa Medical University, Hokkaido, Japan.
authors: Yoshinobu
authors: Y
authors: Ohsaki
authors: Asahikawa Medical University, Hokkaido, Japan.
authors: Tomohisa
authors: T
authors: Watari
authors: Asahikawa Medical University, Hokkaido, Japan.
authors: Eri
authors: E
authors: Toyoshima
authors: Iwate Prefectural Central Hospital, Iwate, Japan.
authors: Kenichi
authors: K
authors: Takeuchi
authors: Iwate Prefectural Central Hospital, Iwate, Japan.
authors: Mayumi
authors: M
authors: Shiokoshi
authors: Saiseikai Yamagata Saisei Hospital, Yamagata, Japan.
authors: Hiroaki
authors: H
authors: Takeda
authors: Japanese Red Cross Sendai Hospital, Miyagi, Japan.
authors: Makoto
authors: M
authors: Miki
authors: Japanese Red Cross Sendai Hospital, Miyagi, Japan.
authors: Toshio
authors: T
authors: Kumagai
authors: Japanese Red Cross Sendai Hospital, Miyagi, Japan.
authors: Susumu
authors: S
authors: Nakanowatari
authors: Saka General Hospital, Miyagi, Japan.
authors: Hiroshi
authors: H
authors: Takahashi
authors: Saka General Hospital, Miyagi, Japan.
authors: Mutsuko
authors: M
authors: Utagawa
authors: Teikyo University School of Medicine, Tokyo, Japan.
authors: Hajime
authors: H
authors: Nishiya
authors: Teikyo University School of Medicine, Tokyo, Japan.
authors: Sayoko
authors: S
authors: Kawakami
authors: National Center for Global Health and Medicine, Tokyo, Japan.
authors: Nobuyuki
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authors: Kobayashi
authors: National Center for Global Health and Medicine, Tokyo, Japan.
authors: Jin
authors: J
authors: Takasaki
authors: National Center for Global Health and Medicine, Tokyo, Japan.
authors: Kazuhisa
authors: K
authors: Mezaki
authors: National Center for Global Health and Medicine, Tokyo, Japan.
authors: Hisami
authors: H
authors: Konosaki
authors: National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors: Yasuko
authors: Y
authors: Aoki
authors: National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors: Yumiko
authors: Y
authors: Yamamoto
authors: National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
authors: Michi
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authors: Shoji
authors: Kyorin University Hospital, Tokyo, Japan.
authors: Hajime
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authors: Goto
authors: Kyorin University Hospital, Tokyo, Japan.
authors: Takeshi
authors: T
authors: Saraya
authors: Kyorin University Hospital, Tokyo, Japan.
authors: Daisuke
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authors: Kurai
authors: Kyorin University Hospital, Tokyo, Japan.
authors: Mitsuhiro
authors: M
authors: Okazaki
authors: Showa University, School of Medicine, Tokyo, Japan.
authors: Yoshihito
authors: Y
authors: Niki
authors: Showa University, School of Medicine, Tokyo, Japan.
authors: Koichiro
authors: K
authors: Yoshida
authors: National Defense Medical College, Saitama, Japan.
authors: Akihiko
authors: A
authors: Kawana
authors: National Defense Medical College, Saitama, Japan.
authors: Katsu
authors: K
authors: Saionji
authors: National Defense Medical College, Saitama, Japan.
authors: Yuji
authors: Y
authors: Fujikura
authors: Yokohama City University Hospital, Kanagawa, Japan.
authors: Naoki
authors: N
authors: Miyazawa
authors: Yokohama City University Hospital, Kanagawa, Japan.
authors: Makoto
authors: M
authors: Kudo
authors: Yokohama City University Hospital, Kanagawa, Japan.
authors: Yoshimi
authors: Y
authors: Sato
authors: Yokohama City University Hospital, Kanagawa, Japan.
authors: Masaki
authors: M
authors: Yamamoto
authors: Toyama Prefectural Central Hospital, Toyama, Japan.
authors: Takashi
authors: T
authors: Yoshida
authors: Toyama Prefectural Central Hospital, Toyama, Japan.
authors: Masahiko
authors: M
authors: Nakamura
authors: Niigata City General Hospital, Niigata, Japan.
authors: Hiroki
authors: H
authors: Tsukada
authors: Niigata City General Hospital, Niigata, Japan.
authors: Yumiko
authors: Y
authors: Imai
authors: Niigata City General Hospital, Niigata, Japan.
authors: Ayami
authors: A
authors: Tsukada
authors: Shinrakuen Hospital, Niigata, Japan.
authors: Satoshi
authors: S
authors: Kawasaki
authors: Shinrakuen Hospital, Niigata, Japan.
authors: Yasuo
authors: Y
authors: Honma
authors: Kasugai Municipal Hospital, Aichi, Japan.
authors: Toshinobu
authors: T
authors: Yamamoto
authors: Kasugai Municipal Hospital, Aichi, Japan.
authors: Nobuyoshi
authors: N
authors: Ban
authors: Aichi Medical University Hospital, Aichi, Japan.
authors: Hiroshige
authors: H
authors: Mikamo
authors: Aichi Medical University Hospital, Aichi, Japan.
authors: Haruki
authors: H
authors: Sawamura
authors: Kinki University, Faculty of Medicine, Osaka, Japan.
authors: Takayuki
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authors: Miyara
authors: Kinki University, Faculty of Medicine, Osaka, Japan.
authors: Hirofumi
authors: H
authors: Toda
authors: Kinki University, Faculty of Medicine, Osaka, Japan.
authors: Kaori
authors: K
authors: Sato
authors: Osaka City General Hospital, Osaka, Japan.
authors: Tadahiro
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authors: Nakamura
authors: Osaka City General Hospital, Osaka, Japan.
authors: Yasunori
authors: Y
authors: Fujikawa
authors: Osaka City General Hospital, Osaka, Japan.
authors: Noriko
authors: N
authors: Mitsuno
authors: Center for Infectious Diseases, Nara Medical University, Nara, Japan.
authors: Keiichi
authors: K
authors: Mikasa
authors: Center for Infectious Diseases, Nara Medical University, Nara, Japan.
authors: Kei
authors: K
authors: Kasahara
authors: Center for Infectious Diseases, Nara Medical University, Nara, Japan.
authors: Reiko
authors: R
authors: Sano
authors: Kobe Red Cross Hospital, Hyogo, Japan.
authors: Keisuke
authors: K
authors: Sugimoto
authors: Osaka University Hospital, Osaka, Japan.
authors: Seishi
authors: S
authors: Asari
authors: Osaka University Hospital, Osaka, Japan.
authors: Isao
authors: I
authors: Nishi
authors: Osaka University Hospital, Osaka, Japan.
authors: Masahiro
authors: M
authors: Toyokawa
authors: Kawasaki Medical School, Okayama, Japan.
authors: Naoyuki
authors: N
authors: Miyashita
authors: Kawasaki Medical School, Okayama, Japan.
authors: Yutaka
authors: Y
authors: Koguchi
authors: Okayama University Hospital, Okayama, Japan.
authors: Nobuchika
authors: N
authors: Kusano
authors: Okayama University Hospital, Okayama, Japan.
authors: Eiichirou
authors: E
authors: Mihara
authors: Hiroshima Prefectural Hospital, Hiroshima, Japan.
authors: Masao
authors: M
authors: Kuwabara
authors: Hiroshima Prefectural Hospital, Hiroshima, Japan.
authors: Yaeko
authors: Y
authors: Watanabe
authors: Matsue Red Cross Hospital, Shimane, Japan.
authors: Yuji
authors: Y
authors: Kawasaki
authors: Matsue Red Cross Hospital, Shimane, Japan.
authors: Kenichi
authors: K
authors: Takeda
authors: Matsue Red Cross Hospital, Shimane, Japan.
authors: Hirokazu
authors: H
authors: Tokuyasu
authors: Matsue Red Cross Hospital, Shimane, Japan.
authors: Kayoko
authors: K
authors: Masui
authors: Kagawa University Hospital, Kagawa, Japan.
authors: Kiyoshi
authors: K
authors: Negayama
authors: Oita University Faculty of Medicine, Oita, Japan.
authors: Kazufumi
authors: K
authors: Hiramatsu
authors: Saga University, School of Medicine, Saga, Japan.
authors: Yosuke
authors: Y
authors: Aoki
authors: Saga University, School of Medicine, Saga, Japan.
authors: Mami
authors: M
authors: Fukuoka
authors: Saga University, School of Medicine, Saga, Japan.
authors: Hiroki
authors: H
authors: Magarifuchi
authors: Saga University, School of Medicine, Saga, Japan.
authors: Zenzo
authors: Z
authors: Nagasawa
authors: Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors: Moritaka
authors: M
authors: Suga
authors: Saiseikai Kumamoto Hospital, Kumamoto, Japan.
authors: Hiroyuki
authors: H
authors: Muranaka
authors: Nagasaki University School of Medicine, Nagasaki, Japan.
authors: Yoshitomo
authors: Y
authors: Morinaga
authors: St. Mary's Hospital, Fukuoka, Japan.
authors: Junichi
authors: J
authors: Honda
authors: Faculty of Medicine, Fukuoka University, Fukuoka, Fukuoka, Japan.
authors: Masaki
authors: M
authors: Fujita
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D003141:Communicable Diseases / Q000188:drug therapy / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Resistance; Respiratory tract infection; Surveillance; Susceptibility