title: A multi-functional tubulovesicular network as the ancestral eukaryotic endomembrane system.
abstract: The origin of the eukaryotic endomembrane system is still the subject of much speculation. We argue that the combination of two recent hypotheses addressing the eukaryotic endomembrane's early evolution supports the possibility that the ancestral membranes were organised as a multi-functional tubulovesicular network. One of the potential selective advantages provided by this organisation was the capacity to perform endocytosis. This possibility is illustrated by membrane organisations observed in current organisms in the three domains of life. Based on this, we propose a coherent model of autogenous eukaryotic endomembrane system evolution in which mitochondria are involved at a late stage.
authors: Centro Andaluz de Biologia del Desarollo (CABD), Universidad Pablo de Olavide, Carretera de Utrera km 1, Seville 41013, Spain. jcgonsan@upo.es.
authors: Juan Carlos
authors: JC
authors: González-Sánchez
authors: Centro Andaluz de Biologia del Desarollo (CABD), Universidad Pablo de Olavide, Carretera de Utrera km 1, Seville 41013, Spain. rjdoscos@upo.es.
authors: Ricardo
authors: R
authors: Costa
authors: Centro Andaluz de Biologia del Desarollo (CABD), Universidad Pablo de Olavide, Carretera de Utrera km 1, Seville 41013, Spain. damienpdevos@gmail.com.
authors: Damien P
authors: DP
authors: Devos