title: The role of the JAK-STAT pathway in neural stem cells, neural progenitor cells and reactive astrocytes after spinal cord injury.
abstract: Patients with spinal cord injuries can develop severe neurological damage and dysfunction, which is not only induced by primary but also by secondary injuries. As an evolutionarily conserved pathway of eukaryotes, the JAK-STAT pathway is associated with cell growth, survival, development and differentiation; activation of the JAK-STAT pathway has been previously reported in central nervous system injury. The JAK-STAT pathway is directly associated with neurogenesis and glia scar formation in the injury region. Following injury of the axon, the overexpression and activation of STAT3 is exhibited specifically in protecting neurons. To investigate the role of the JAK-STAT pathway in neuroprotection, we summarized the effect of JAK-STAT pathway in the following three sections: Firstly, the modulation of JAK-STAT pathway in proliferation and differentiation of neural stem cells and neural progenitor cells is discussed; secondly, the time-dependent effect of JAK-STAT pathway in reactive astrocytes to reveal their capability of neuroprotection is revealed and lastly, we focus on how the astrocyte-secretory polypeptides (astrocyte-derived cytokines and trophic factors) accomplish neuroprotection via the JAK-STAT pathway.
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China ; Department of Orthopedics, The 266th Hospital of the Chinese People's Liberation Army, Chengde, Hebei 067000, P.R. China.
authors: Tianyi
authors: T
authors: Wang
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Wenqi
authors: W
authors: Yuan
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Yong
authors: Y
authors: Liu
authors: Department of Orthopedics, Capital Medical University Luhe Hospital, Beijing 100000, P.R. China.
authors: Yanjun
authors: Y
authors: Zhang
authors: Department of Paediatric Internal Medicine, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.
authors: Zhijie
authors: Z
authors: Wang
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Xianhu
authors: X
authors: Zhou
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Guangzhi
authors: G
authors: Ning
authors: Department of Orthopedics, The Second Hospital of Tianjin Medical University, Tianjin 300211, P.R. China.
authors: Liang
authors: L
authors: Zhang
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Liwei
authors: L
authors: Yao
authors: Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors: Shiqing
authors: S
authors: Feng
authors: School of Medicine, Nankai University, Tianjin 300071, P.R. China.
authors: Xiaohong
authors: X
authors: Kong
keywords: JAK-STAT pathway; astrocyte-secretory polypeptides; neural progenitor cells; neural stem cells; reactive astrocyte; spinal cord injury