title: The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma.
abstract: The high mortality rate in advanced lung cancer, due to a preponderance of tumors discovered at advanced stage, demands the discovery and clinical validation of biomarkers for diagnosing early stage disease. Quantitative proteomics technologies are capable of identifying protein biomarkers with diagnostic, prognostic, and predictive value. Recent works have demonstrated the utility in using quantitative proteomics across normal, pre-cancerous, and cancerous lesions towards the discovery of biomarkers for early stage lung cancer, as well as discovering novel mechanisms of lung carcinogenesis.
authors: Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA ;
authors: Timothy G
authors: TG
authors: Whitsett
authors: Center for Thoracic Disease and Transplantation, Heart and Lung Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
authors: Landon J
authors: LJ
authors: Inge
authors: Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ, USA ;
authors: Nhan L
authors: NL
authors: Tran
keywords: Lung squamous cell carcinoma; glutathione s-transferase pi 1 (GSTP1); isobaric tags for relative and absolute quantitation (iTRAQ); proteomics