title: Deciphering associations for lung cancer risk through imputation and analysis of 12,316 cases and 16,831 controls.
abstract: Recent genome-wide association studies have identified common variants at multiple loci influencing lung cancer risk. To decipher the genetic basis of the association signals at 3q28, 5p15.33, 6p21.33, 9p21 and 12p13.33, we performed a meta-analysis of data from five genome-wide association studies in populations of European ancestry totalling 12 316 lung cancer cases and 16 831 controls using imputation to recover untyped genotypes. For four of the regions, it was possible to refine the association signal identifying a smaller region of interest likely to harbour the functional variant. Our analysis did not provide evidence that any of the associations at the loci being a consequence of synthetic associations rather than linkage disequilibrium with a common risk variant at these risk loci.
authors: Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, Sutton, UK.
authors: Yufei
authors: Y
authors: Wang
authors: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors: Yongyue
authors: http://orcid.org/0000-0002-1132-1796
authors: Y
authors: Wei
authors: International Agency for Research on Cancer (IARC, World Health Organization (WHO)), Lyon, France.
authors: Valerie
authors: V
authors: Gaborieau
authors: Division of Cancer Epidemiology and Genetics, National Cancer institute, NIH, DHHS, Bethesda, MD, USA.
authors: Jianxin
authors: J
authors: Shi
authors: Department of Community and Family Medicine, Geisel School of Medicine, Center for Genomic Medicine, Lebanon, NH, USA.
authors: Younghun
authors: Y
authors: Han
authors: International Agency for Research on Cancer (IARC, World Health Organization (WHO)), Lyon, France.|Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
authors: Maria N
authors: MN
authors: Timofeeva
authors: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors: Li
authors: L
authors: Su
authors: Department of Community and Family Medicine, Geisel School of Medicine, Center for Genomic Medicine, Lebanon, NH, USA.
authors: Yafang
authors: Y
authors: Li
authors: Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.
authors: Timothy
authors: T
authors: Eisen
authors: Department of Community and Family Medicine, Geisel School of Medicine, Center for Genomic Medicine, Lebanon, NH, USA.
authors: Christopher I
authors: CI
authors: Amos
authors: Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD, USA.
authors: Maria Teresa
authors: MT
authors: Landi
authors: Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
authors: David C
authors: DC
authors: Christiani
authors: International Agency for Research on Cancer (IARC, World Health Organization (WHO)), Lyon, France.
authors: James D
authors: JD
authors: McKay
authors: Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, Sutton, UK.
authors: Richard S
authors: RS
authors: Houlston
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056426:Genetic Loci; D055106:Genome-Wide Association Study; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged