title: Vasohibin-1 suppresses colon cancer.
abstract: Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor.However, the clinical relevance of VASH1 in colon cancer and its regulations on cancer angiogenesis and cancer cell biological characteristics are still unknown. Here we showed that stromal VASH1 levels were negatively correlated with tumor size, advanced clinical stage and distant metastases in colon cancer patients. Overexpression of VASH1 in colon cancer cells induced apoptosis and senescence, inhibiting cancer cell growth and colony formation in vitro and tumor growth in vivo. In addition, knockdown of VASH1 in cancer cells promoted cell growth, adhesion and migration in vitro, and enhanced tumorigenesis and metastasis in vivo.
authors: Department of Oncology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, P. R. China.|Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
authors: Shuai
authors: S
authors: Liu
authors: Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.|Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, P.R. China.
authors: Bing
authors: B
authors: Han
authors: Department of Genetics, Washington University School of Medicine, Saint Louis, MO, USA.
authors: Qunyuan
authors: Q
authors: Zhang
authors: Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
authors: Jie
authors: J
authors: Dou
authors: Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
authors: Fang
authors: F
authors: Wang
authors: Department of Oncology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, P. R. China.
authors: Wenli
authors: W
authors: Lin
authors: Department of Oncology, Jinan Central Hospital, Affiliated to Shandong University, Jinan, P. R. China.
authors: Yuping
authors: Y
authors: Sun
authors: Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.
authors: Guangyong
authors: G
authors: Peng
mesh_terms: D000368:Aged; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D055785:Gene Knockdown Techniques; D045325:HCT116 Cells; D057809:HEK293 Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008822:Mice, Transgenic; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: D018797:Cell Cycle Proteins; C493181:VASH1 protein, human
keywords: VASH1; angiogenesis; colon cancer; metastasis; tumor suppressor