title: [Possibilities of modern imaging technologies in early diagnosis of Alzheimer disease].
abstract: Recent advances in neuroimaging technology and image analysis algorithms have significantly contributed to a better understanding of spatial and temporal aspects of brain change associated with Alzheimer Disease. The current review will demonstrate how functional (fMRI) and structural magnetic resonance imaging (MRI) techniques may be used to identify distinct patterns of brain change associated with disease progression and also increased risk for Alzheimer Disease. Moreover, Positron Emission Tomography (PET) based measures of glucosemetabolism (Fluorodeoxyglucose, FDG) and Amyloid-beta plaque density (11-C-Pittsburgh Compound B, PiB and 18-F) will be reviewed regarding their diagnostic value for assessing the individual degree of Alzheimer -pathology and thus complement the information provided by MRI and other clinical measures.
authors: Klinik für Alterspsychiatrie der Universität Zürich.
authors: Paul G
authors: PG
authors: Unschuld
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D042241:Early Diagnosis; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D058225:Plaque, Amyloid / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D049268:Positron-Emission Tomography / Q000379:methods*; D013557:Switzerland
chemical_list: D019788:Fluorodeoxyglucose F18