title: Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy.
abstract: This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for postoperative pain management in dogs. Twenty dogs undergoing mastectomy were randomized to receive perioperative oral placebo or gabapentin (10 mg/kg). All dogs were premedicated with intramuscular acepromazine (0.03 mg/kg) and morphine (0.3 mg/ kg). Anesthesia was induced with propofol (4 mg/kg) intravenously and maintained with isoflurane. Intravenous meloxicam (0.2 mg/kg) was administered preoperatively. Postoperative analgesia was evaluated for 72 hr. Rescue analgesia was provided with intramuscular morphine (0.5 mg/kg). Dogs in the Placebo group received significantly more morphine doses than the Gabapentin group (P=0.021), despite no significant differences in pain scores. Perioperative gabapentin reduced the postoperative morphine requirements in dogs after mastectomy.
authors: Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary Medicine, Universidade do Oeste Paulista, Presidente Prudente, Brazil.
authors: Giulianne Carla
authors: GC
authors: Crociolli
authors: Renata Navarro
authors: RN
authors: Cassu
authors: Rafael Cabral
authors: RC
authors: Barbero
authors: Thalita Leone A
authors: TL
authors: Rocha
authors: Denis Robson
authors: DR
authors: Gomes
authors: Gabriel Montoro
authors: GM
authors: Nicácio
mesh_terms: D000759:Adjuvants, Anesthesia / Q000627:therapeutic use; D000588:Amines / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000758:Anesthesia / Q000379:methods / Q000662:veterinary; D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004285:Dogs / Q000601:surgery*; D005260:Female; D000077206:Gabapentin; D008408:Mastectomy / Q000662:veterinary*; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D059408:Pain Management / Q000379:methods / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000759:Adjuvants, Anesthesia; D000588:Amines; D000700:Analgesics; D000701:Analgesics, Opioid; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D009020:Morphine