title: Dynamic perfusion CT in brain tumors.
abstract: Dynamic perfusion CT (PCT) is an imaging technique for assessing the vascular supply and hemodynamics of brain tumors by measuring blood flow, blood volume, and permeability-surface area product. These PCT parameters provide information complementary to histopathologic assessments and have been used for grading brain tumors, distinguishing high-grade gliomas from other brain lesions, differentiating true progression from post-treatment effects, and predicting prognosis after treatments. In this review, the basic principles of PCT are described, and applications of PCT of brain tumors are discussed. The advantages and current challenges, along with possible solutions, of PCT are presented.
authors: Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Robarts Research Institute, The University of Western Ontario, 1151 Richmond St. N., London, Ontario, Canada N6A 5B7. Electronic address: timothy.yeung@lhsc.on.ca.
authors: Timothy Pok Chi
authors: TP
authors: Yeung
authors: Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Department of Oncology, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6. Electronic address: glenn.bauman@lhsc.on.ca.
authors: Glenn
authors: G
authors: Bauman
authors: Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Department of Oncology, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6. Electronic address: slav.yartsev@lhsc.on.ca.
authors: Slav
authors: S
authors: Yartsev
authors: Azienda Ospedaliero-Universitaria di Ferrara, Neuroradiology Unit-Department of Neuroscience and Rehabilitation-Azienda, Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna, Via Aldo Moro, 8 - (Italy), Cona, Ferrara, Ferrara 44124 Italy. Electronic address: henryfai@tin.it.
authors: Enrico
authors: E
authors: Fainardi
authors: London Regional Cancer Program, London Health Sciences Centre, 790 Commissioners Road East, London, ON, Canada N6A 5W9; Department of Oncology, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6; Department of Clinical Neurological Sciences, The University of Western Ontario, University, Hospital, London Health Sciences Centre, 339 Windermere Road, London Ontario Canada N6A 5A5. Electronic address: david.macdonald@lhsc.on.ca.
authors: David
authors: D
authors: Macdonald
authors: Department of Medical Biophysics, The University of Western Ontario, 1151 Richmond Street N., London, Ontario, Canada N6A 5C1; Robarts Research Institute, The University of Western Ontario, 1151 Richmond St. N., London, Ontario, Canada N6A 5B7; Department of Oncology, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, 790 Commissioners Road East, London, Ontario, Canada N6A 4L6; Department of Medical Imaging, The University of Western Ontario, Victoria Hospital, London Health Sciences Centre, London, Ontario, Canada N6A 5W9; Lawson Imaging Program, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2. Electronic address: tlee@imaging.robarts.ca.
authors: Ting-Yim
authors: TY
authors: Lee
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005910:Glioma / Q000098:blood supply / Q000000981:diagnostic imaging*; D006801:Humans; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Adiabatic Approximation of Johnson and Wilson Model; Blood flow; Blood volume; Brain tumor; Dynamic perfusion CT; Permeability-surface area product