title: Clinical and radiographic evaluation of nanocrystalline hydroxyapatite with or without platelet-rich fibrin membrane in the treatment of periodontal intrabony defects.
abstract: BACKGROUND
  Nano-sized ceramics may represent a promising class of bone graft substitutes due to their improved osseointegrative properties. Nanocrystalline hydroxyapatite (NcHA) binds to bone and stimulate bone healing by stimulation of osteoblast activity. Platelet-rich fibrin (PRF), an intimate assembly of cytokines, glycan chains, and structural glycoproteins enmeshed within a slowly polymerized fibrin network, has the potential to accelerate soft and hard tissue healing. The present study aims to explore the clinical and radiographical outcome of NcHA bone graft with or without PRF, in the treatment of intrabony periodontal defects.
  
  
  METHODS
  In a split-mouth study design, 20 patients having two almost identical intrabony defects with clinical probing depth of at least 6 mm were selected for the study. Selected sites were randomly divided into two groups. In Group I, mucoperiosteal flap elevation followed by the placement of NcHA was done. In Group II, mucoperiosteal flap elevation, followed by the placement of NcHA with PRF was done. Clinical and radiographic parameters were recorded at baseline and at 6-month postoperatively.
  
  
  RESULTS
  Both treatment groups showed a significant probing pocket depth (PPD) reduction, clinical attachment gain, increase bone density 6-month after surgery compared with baseline. However, there was a significantly greater PPD reduction and clinical attachment gain when PRF was added to NcHA.
  
  
  CONCLUSIONS
  The NcHA bone graft in combination with PRF demonstrated clinical advantages beyond that achieved by the NcHA alone.
authors: Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, October 6 University, Giza, Egypt.
authors: Enas Ahmed
authors: EA
authors: Elgendy
authors: Department of Oral Medicine, Periodontology, Oral Diagnosis and Oral Radiology, Tanta University, Tanta, Egypt.
authors: Tamer Elamer
authors: TE
authors: Abo Shady
keywords: Nanocrystalline hydroxyapatite; periodontal regeneration; platelet-rich fibrin