title: Synthesis, characterization, hydrolase and catecholase activity of a dinuclear iron(III) complex: Catalytic promiscuity.
abstract: Herein, we report the synthesis and characterization of the new di-iron(III) complex [(bbpmp)(H2O)(Cl)Fe(III)(μ-Ophenoxo)Fe(III)(H2O)Cl)]Cl (1), with the symmetrical ligand 2,6-bis{[(2-hydroxybenzyl)(pyridin-2-yl)methylamino]methyl}-4-methylphenol (H3bbpmp). Complexes 2 with the unsymmetrical ligand H2bpbpmp - {2-[[(2-hydroxybenzyl)(2-pyridylmethyl)]aminomethyl]-6-bis(pyridylmethyl) aminomethyl}-4-methylphenol and 3 with the ligand L(1)=4,11-dimethyl-1,8-bis{2-[N-(di-2-pyridylmethyl)amino]ethyl}cyclam were included for comparison purposes. Complex 1 was characterized through elemental analysis, X-ray crystallography, magnetochemistry, electronic spectroscopy, electrochemistry, mass spectrometry and potentiometric titration. The magnetic data show a very weak antiferromagnetic coupling between the two iron centers of the dinuclear complex 1 (J=-0.29cm(-1)). Due to the presence of labile coordination sites in both iron centers the hydrolysis of both the diester model substrate 2,4-BDNPP and DNA was studied in detail. Complex 1 was also able to catalyze the oxidation of the substrate 3,5-di-tert-butylcatechol (3,5-DTBC) to give the corresponding quinone, and thus it can be considered as a catalytically promiscuous system.
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors: Tiago P
authors: TP
authors: Camargo
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors: Fernanda F
authors: FF
authors: Maia
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors: Cláudia
authors: C
authors: Chaves
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors: Bernardo
authors: B
authors: de Souza
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors: Adailton J
authors: AJ
authors: Bortoluzzi
authors: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
authors: Nathalia
authors: N
authors: Castilho
authors: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
authors: Tiago
authors: T
authors: Bortolotto
authors: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
authors: Hernán
authors: H
authors: Terenzi
authors: Instituto de Física, Universidade de São Paulo, 13360-979 São Carlos, SP, Brazil.
authors: Eduardo E
authors: EE
authors: Castellano
authors: Institut für Physikalishe Chemie, Technische Universität Darmstadt, Petersenstraße 20, D-64287 Darmstadt, Germany.
authors: Wolfgang
authors: W
authors: Haase
authors: Institute of Physics, Reymonta 4, Jagiellonian University, PL-30-059 Krakow, Poland.
authors: Zbigniew
authors: Z
authors: Tomkowicz
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil. Electronic address: rosely.peralta@ufsc.br.
authors: Rosely A
authors: RA
authors: Peralta
authors: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil. Electronic address: ademir.neves@ufsc.br.
authors: Ademir
authors: A
authors: Neves
mesh_terms: D002384:Catalysis; D004156:Catechol Oxidase / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006867:Hydrolases / Q000737:chemistry*; D058085:Iron Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013379:Substrate Specificity
chemical_list: D005290:Ferric Compounds; D058085:Iron Compounds; D004247:DNA; D004156:Catechol Oxidase; D006867:Hydrolases
keywords: Catalytic promiscuity; DNA cleavage; Dinuclear iron(III) complex