title: Crossfinder-assisted mapping of protein crosslinks formed by site-specifically incorporated crosslinkers.
abstract: Protein crosslinking has been used for decades to derive structural information about proteins and protein complexes. Only recently, however, it became possible to map the amino acids involved in the crosslinks with the advent of high resolution mass spectrometry (MS). Here, we present Crossfinder, which automates the search for crosslinks formed by site-specifically incorporated crosslinking amino acids in LC-MS-MS data.
  
  
  METHODS
  An executable version of Crossfinder for Windows machines (64-bit) is freely available to non-commercial users. It is bundled with a manual and example data.
authors: BioMedical Center, Ludwig-Maximilians-University, 80336 Munich, Germany.
authors: Felix
authors: F
authors: Mueller-Planitz
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006801:Humans; D046912:Multiprotein Complexes / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D000596:Amino Acids; D003432:Cross-Linking Reagents; D046912:Multiprotein Complexes; D011506:Proteins