title: Higher mobility scores in patients with cystic fibrosis are associated with better lung function.
abstract: OBJECTIVE
  The purpose of this study was to determine whether mobility and physical activity were associated with lung function in adults with cystic fibrosis (CF).
  
  
  METHODS
  This was a prospective cohort observational study in an urban, academic, specialized care center. Participants were ambulatory, nonhospitalized adults with CF.
  
  
  METHODS
  Mobility was assessed monthly by the Life-Space Assessment (LSA) questionnaire and quarterly by pedometer. Lung function was assessed by spirometry.
  
  
  RESULTS
  Twenty-seven subjects participated. Subjects recorded mean pedometer steps of 20,213 ± 11,331 over three days and FEV1% predicted of 77.48% ± 22.60% over one year. The LSA score at enrollment was correlated with initial pedometer steps (r = 0.42 and P = 0.03), and mean LSA score over one year was correlated with mean number of steps (r = 0.51 and P = 0.007). LSA mobility and pedometer scores were correlated with FEV1% predicted at enrollment and throughout the study.
  
  
  CONCLUSIONS
  Mobility and physical activity measured by LSA questionnaire and pedometer are positively associated with lung function in adults with CF. This study confirms the importance of mobility and physical activity and supports the utility of a simple office-based questionnaire as a measure of mobility in adults with CF.
authors: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors: Aneesha
authors: A
authors: Thobani
authors: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA ; Nutrition Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
authors: Jessica A
authors: JA
authors: Alvarez
authors: Emory University Cystic Fibrosis Center, Atlanta, GA 30322, USA.
authors: Shaina
authors: S
authors: Blair
authors: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors: Kaila
authors: K
authors: Jackson
authors: The University of Maryland School of Medicine, Baltimore, MD 21201, USA.
authors: Eric R
authors: ER
authors: Gottlieb
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors: Seth
authors: S
authors: Walker
authors: Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA ; Nutrition Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA ; Emory University Cystic Fibrosis Center, Atlanta, GA 30322, USA ; Atlanta VA Medical Center, Decatur, GA 30022, USA.
authors: Vin
authors: 0000-0002-4021-5853
authors: V
authors: Tangpricha
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D011446:Prospective Studies; D011788:Quality of Life; D013147:Spirometry; D011795:Surveys and Questionnaires; D055815:Young Adult