title: The effects of PON1 gene Q192R variant on the development of uterine leiomyoma in Turkish patients.
abstract: OBJECTIVE
  This study aimed to analyze the relation between uterine leiomyoma (ULM) patients and p.Q192R polymorphism.
  
  
  METHODS
  ULM patients (n=76) and healthy women (n=103) were recruited from the Yeditepe University, Department of Gynecology and Obstetrics. The genotype and allele distribution of p.Q192R was analyzed by polymerase chain reaction and restriction fragment length polymorphism methods. Genotype and allele frequencies between study groups were calculated by the chi-square (χ(2)) and Fischer's exact test.
  
  
  RESULTS
  The frequency of the B allele was lower in patients (p<0.001) and the AB genotype showed a decreased risk for ULM development (p<0.001). The variation was unrelated to ULM size and number. There was no significant difference between p.Q192R genotype frequencies and fibroid size and number.
  
  
  CONCLUSIONS
  The heterogeneous AB genotype of PON1 p.Q192R variation could be recognized as a low-risk parameter for the development of ULM in Turkish women.
authors: Department of Gynecology, Yeditepe University Hospital, Istanbul, Turkey.
authors: Rukset
authors: R
authors: Attar
authors: Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
authors: Hande
authors: H
authors: Atasoy
authors: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors: Güldal
authors: G
authors: İnal-Gültekin
authors: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors: Özlem
authors: Ö
authors: Timirci-Kahraman
authors: Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey.
authors: Seda
authors: S
authors: Güleç-Yilmaz
authors: Yeditepe University Hospital, Istanbul, Turkey.
authors: Altay Burak
authors: AB
authors: Dalan
authors: Department of Gynecology, Yeditepe University Hospital, Istanbul, Turkey.
authors: Gazi
authors: G
authors: Yildirim
authors: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors: Arzu
authors: A
authors: Ergen
authors: Department of Medical Biology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey turgay.isbir@yeditepe.edu.tr tisbir@superonline.com.
authors: Turgay
authors: T
authors: Isbir
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014421:Turkey
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: PON 192; Uterine benign tumor; cancer; ethnicity; paraoxanase