title: Diffuse alveolar hemorrhage due to valproic acid: Case report and review of the literature.
abstract: Valproic acid (VPA) is one of the most frequently used antiepileptic drugs for the treatment of focal and generalized epilepsies, absence seizures, and Lennox-Gastaut syndrome (LGS). VPA has been demonstrated to have a negative effect on both the intrinsic and extrinsic coagulation systems and controversy exists about the clinical relevance of such hematological abnormalities. We describe a case of reversible lung hemorrage due to VPA. In English-language literature only two other similar cases (one of which fatal) have been described so far.
authors: Department of Thoracic Surgery, Morelli Hospital, AOVV, Sondalo, Italy.
authors: Francesco
authors: F
authors: Inzirillo
authors: Department of Thoracic Surgery, Morelli Hospital, AOVV, Sondalo, Italy.
authors: Casimiro
authors: C
authors: Giorgetta
authors: Department of Thoracic Surgery, Morelli Hospital, AOVV, Sondalo, Italy.
authors: Eugenio
authors: E
authors: Ravalli
authors: Department of Thoracic Surgery, Morelli Hospital, AOVV, Sondalo, Italy.
authors: Claudio Della
authors: CD
authors: Pona
keywords: Alveolar hemorrhage; coagulation disorders; valproic acid