title: Repression of AS2 by WOX family transcription factors is required for leaf development in Medicago and Arabidopsis.
abstract: WOX transcription factors are key regulators of meristematic activity in plants. The Medicago WOX gene, STF, functions in maintenance of leaf marginal meristem, analogous to the function of WUS in the shoot apical meristem. Both STF and WUS directly repress AS2 expression in their respective domains. Ectopic expression of AS2 with WUS promoter leads to a narrow leaf phenotype and other phenotypes similar to the wus mutant. We also found that a wox1 prs wus triple mutant produces much narrower leaf blades than the wox1 prs double mutant, indicating that WUS genetically interacts with WOX1 and PRS in Arabidopsis leaf blade development. Our data points to a general requirement for AS2 repression in meristematic regions to allow cell proliferation.
authors: a Department of Plant and Soil Sciences; Institute for Agricultural Biosciences ; Oklahoma State University ; Ardmore , OK USA.
authors: Fei
authors: F
authors: Zhang
authors: Million
authors: M
authors: Tadege
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D046913:Medicago truncatula / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D018515:Plant Leaves / Q000254:growth & development* / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C463739:AS2 protein, Arabidopsis; D029681:Arabidopsis Proteins; D018398:Homeodomain Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C568610:WOX1 protein, Arabidopsis
keywords: AS2; Arabidopsis thaliana; Medicago truncatula; STF,; TOPLESS; WOX transcription factor; WUS; co-repressor; leaf development