title: Anti-inflammatory flavanol glycosides from Saraca asoca bark.
abstract: Saraca asoca (Roxb.) de Wilde, a common tree of India, is popularly used in the Ayurvedic and modern herbal systems of medicine for genito-urinary problems of women. Considering the reported antimicrobial or anti-inflammatory effect of S. asoca bark against such infections, we studied the anti-inflammatory activity-guided isolation of active compounds from methanol extract. The methanol extract of bark has yielded 10 compounds out of which 3'-deoxyepicatechin-3-O-β-D-glucopyranoside (6) and 3'-deoxycatechin-3-O-α-L-rhamnopyranoside (8) have been found to be in vitro and in vivo active. 3',5-Dimethoxy epicatechin (3), 3'-deoxyepicatechin-3-O-β-D-glucopyranoside (6), 3'-deoxycatechin-3-O-α-L-rhamnopyranoside (8) and epigallocatechin (9) are being reported for the first time from S. asoca.
authors: a Chemical Sciences Division, CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow 226015 , India.|b Academy of Scientific and Innovative Research , CIMAP Campus, Lucknow 226015 , India.
authors: Furkan
authors: F
authors: Ahmad
authors: a Chemical Sciences Division, CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow 226015 , India.
authors: Laxminarain
authors: L
authors: Misra
authors: a Chemical Sciences Division, CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow 226015 , India.
authors: Rashi
authors: R
authors: Tewari
authors: a Chemical Sciences Division, CSIR - Central Institute of Medicinal and Aromatic Plants , Lucknow 226015 , India.
authors: Preeti
authors: P
authors: Gupta
authors: c Pharmacology Division, CSIR - Central Drug Research Institute , Sitapur Road, Lucknow 226031 , India.
authors: Pratikshita
authors: P
authors: Mishra
authors: c Pharmacology Division, CSIR - Central Drug Research Institute , Sitapur Road, Lucknow 226031 , India.
authors: Rakesh
authors: R
authors: Shukla
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D007194:India; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D059808:Polyphenols / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000611356:3'-deoxycatechin-3-O-alpha-L-rhamnopyranoside; C000611355:3'-deoxyepicatechin-3-O-beta-D-glucopyranoside; D000893:Anti-Inflammatory Agents; D006027:Glycosides; D010936:Plant Extracts; D059808:Polyphenols; D002392:Catechin
keywords: Saraca asoca (Roxb.) de Wild. syn. S. indica Linn; anti TNF-α activity; anti-inflammatory activity; flavan-3-O-glycosides