title: Effects of heterologous platelet-rich plasma gel on standardized dermal wound healing in rabbits.
abstract: OBJECTIVE
  To evaluate the potential of heterologous platelet-rich plasma (PRP) gel for surgical skin wound healing in rabbits.
  
  
  METHODS
  Blood from a single healthy dog was used for PRP production, with calcium gluconate added to the PRP to form the gel. Two surgical excisions, one to the right and the other to the left of the dorsal midline, were made in six rabbits. One side was randomly allocated to topical application of a physiological solution, and the other was allocated to treatment with heterologous PRP gel. Clinical assessments (weight, pain sensitivity, coloring, edema, hyperemia, exudation, crust, and granulation) and morphometric evaluations were performed 0, 3, 7, 10, 14, and 17 days postoperatively. Histological analysis was performed on the 17th day.
  
  
  RESULTS
  With the exception of the presence of a crust at day 10, clinical variables did not differ significantly between the experimental groups. In both the control and PRP-treated groups, differences were identified when comparing time-points in terms of wound area reduction. Histological results indicated no significant differences between the control group and the PRP-treated group.
  
  
  CONCLUSIONS
  Heterologous platelet-rich plasma gel promoted dermal wound healing in rabbits with no adverse effects.
authors: Oeste Paulista University, Presidente Prudente, SP, Brazil.
authors: Karina Gomes Barros
authors: KG
authors: Abegão
authors: School of Veterinary Medicine, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Bruno Nascimento
authors: BN
authors: Bracale
authors: School of Veterinary Medicine, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Inara Guastini
authors: IG
authors: Delfim
authors: Oeste Paulista University, Presidente Prudente, SP, Brazil.
authors: Eliane Szücs dos
authors: ES
authors: Santos
authors: Department of Clinical Pathology, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Cecília Braga
authors: CB
authors: Laposy
authors: Department of Pathology, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Gisele Alborghetti
authors: GA
authors: Nai
authors: Department of Microbiology, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Rogério
authors: R
authors: Giuffrida
authors: Department of Medical Clinic, UNOESTE, Presidente Prudente, SP, Brazil.
authors: Rosa Maria Barilli
authors: RM
authors: Nogueira
mesh_terms: D000818:Animals; D001706:Biopsy; D004285:Dogs; D005260:Female; D005782:Gels; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D011817:Rabbits; D011897:Random Allocation; D015203:Reproducibility of Results; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014183:Transplantation, Heterologous; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D005782:Gels; D010982:Platelet-Derived Growth Factor