title: Survival and mortality among users and non-users of hydroxyurea with sickle cell disease.
abstract: OBJECTIVE
  to estimate survival, mortality and cause of death among users or not of hydroxyurea with sickle cell disease.
  
  
  METHODS
  cohort study with retrospective data collection, from 1980 to 2010 of patients receiving inpatient treatment in two Brazilian public hospitals. The survival probability was determined using the Kaplan-Meier estimator, survival calculations (SPSS version 10.0), comparison between survival curves, using the log rank method. The level of significance was p=0.05.
  
  
  RESULTS
  of 63 patients, 87% had sickle cell anemia, with 39 using hydroxyurea, with a mean time of use of the drug of 20.0±10.0 years and a mean dose of 17.37±5.4 to 20.94±7.2 mg/kg/day, raising the fetal hemoglobin. In the comparison between those using hydroxyurea and those not, the survival curve was greater among the users (p=0.014). A total of 10 deaths occurred, with a mean age of 28.1 years old, and with Acute Respiratory Failure as the main cause.
  
  
  CONCLUSIONS
  the survival curve is greater among the users of hydroxyurea. The results indicate the importance of the nurse incorporating therapeutic advances of hydroxyurea in her care actions.
authors: Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors: Olinda Maria Rodrigues
authors: OM
authors: de Araujo
authors: Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors: Maria Lúcia
authors: ML
authors: Ivo
authors: Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
authors: Marcos Antonio
authors: MA
authors: Ferreira Júnior
authors: Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors: Elenir Rose Jardim Cury
authors: ER
authors: Pontes
authors: Universidade Federal de Mato Grosso do Sul, Três Lagoas, MS, Brazil.
authors: Ieda Maria Gonçalves Pacce
authors: IM
authors: Bispo
authors: Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors: Eveny Cristine Luna
authors: EC
authors: de Oliveira
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000188:drug therapy* / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
chemical_list: D006918:Hydroxyurea