title: Neuropsychological and neuroimaging characteristics of amnestic mild cognitive impairment subtypes: a selective overview.
abstract: Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. Amnestic mild cognitive impairment (aMCI) is considered to represent early AD. Various aMCI clinical subtypes have been identified as either single domain (SD) or multidomain (MD). The various subtypes represent heterogeneous syndrome, indicating the different probability of progression to AD. Understanding the heterogeneous concept of aMCI can help to construct potential biomarkers to monitor the progression of aMCI to AD. This review provides an overview of various neuroimaging measures for subtypes of aMCI. Focusing on neuropsychological, structural, and functional neuroimaging findings, we found that aMCI showed differences in clinical progression and the abnormalities in MD-aMCI were distributed across temporal, frontal, and parietal cortices, which is similar to AD. This is also compatible with the notion that MD-aMCI is a transition stage between SD-aMCI and AD. Our review provided a framework for the diagnosis of clinical subtypes of aMCI and early detection and intervention of the progression from aMCI to AD.
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|BABRI Centre, Beijing Normal University, Beijing, China.
authors: Xin
authors: X
authors: Li
authors: State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|BABRI Centre, Beijing Normal University, Beijing, China.
authors: Zhan-Jun
authors: ZJ
authors: Zhang
mesh_terms: D000647:Amnesia / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D059906:Neuroimaging; D009483:Neuropsychological Tests
keywords: Alzheimer's disease; Amnestic mild cognitive impairment; Amyloid PET; Morphology; fMRI