title: Minireview: prolactin regulation of adult stem cells.
abstract: Adult stem/progenitor cells are found in many tissues, where their primary role is to maintain homeostasis. Recent studies have evaluated the regulation of adult stem/progenitor cells by prolactin in various target tissues or cell types, including the mammary gland, the prostate, the brain, the bone marrow, the hair follicle, and colon cancer cells. Depending on the tissue, prolactin can either maintain stem cell quiescence or, in contrast, promote stem/progenitor cell expansion and push their progeny towards differentiation. In many instances, whether these effects are direct or involve paracrine regulators remains debated. This minireview aims to overview the current knowledge in the field.
authors: Institut Necker Enfants Malades, Inserm Unité1151, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8253, Team Prolactin/Growth Hormone Pathophysiology, Faculty of Medicine, University Paris Descartes, Sorbonne Paris Cité, 75014 Paris, France.
authors: Lucila
authors: L
authors: Sackmann-Sala
authors: Jacques-Emmanuel
authors: JE
authors: Guidotti
authors: Vincent
authors: V
authors: Goffin
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D000066673:Cell Self Renewal; D006801:Humans; D011388:Prolactin / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D011388:Prolactin