title: Synthesis of novel dihydropyridothienopyrimidin-4,9-dione derivatives.
abstract: A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.
authors: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea. 213501@kist.re.kr.|Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 120-749, Korea. 213501@kist.re.kr.
authors: Youngjae
authors: Y
authors: Kim
authors: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea. djbaek@smu.ac.kr.|Department of Chemistry, College of Natural Sciences, Sangmyung University, Seoul 110-743, Korea. djbaek@smu.ac.kr.
authors: Minjoo
authors: M
authors: Kim
authors: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea. jstae@yonsei.ac.kr.|Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea. jstae@yonsei.ac.kr.
authors: Mooseong
authors: M
authors: Park
authors: Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea. jstae@yonsei.ac.kr.
authors: Jinsung
authors: J
authors: Tae
authors: Department of Chemistry, College of Natural Sciences, Sangmyung University, Seoul 110-743, Korea. djbaek@smu.ac.kr.
authors: Du-Jong
authors: DJ
authors: Baek
authors: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea. jstae@yonsei.ac.kr.|Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea. jstae@yonsei.ac.kr.
authors: Ki Duk
authors: KD
authors: Park
authors: Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea. hchoo@kist.re.kr.|Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea. hchoo@kist.re.kr.
authors: Hyunah
authors: H
authors: Choo
mesh_terms: D001596:Benzylamines / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*
chemical_list: D001596:Benzylamines; D011743:Pyrimidines; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; C476003:thienopyrimidine; C091000:4-methoxybenzylamine; C030796:benzylamine