title: Effect of On-Line Hemodiafiltration on P-Wave Dispersion in Children.
abstract: P-wave dispersion (PWD) (difference between the maximum and minimum P-wave duration), has been proposed as a useful predictor of paroxysmal atrial fibrillation (AF). The consequences of hemodialysis (HD) on PWD and P-wave duration have not been unequivocally documented and understood, and may be complex. We aimed in this work to demonstrate the effects of online hemodiafiltration (OL-HDF) on the risk of developing AF through assessment of PWD. Thirty-three pediatric patients (14 males and 19 females with mean age of 11.66 ± 2.93 years) on conventional HD for at least 6 months underwent echocardiography, 12-lead electrocardiogram and PWD calculation. Then they were switched to OL-HDF for another 6 months and same parameters were reassessed. Thirty sex- and aged-matched healthy children, served as controls. PWD significantly decreased upon switching to OL-HDF (P < 0.001) and fractional shortening significantly improved (P < 0.001). Mean PWD of controls (24 ± 6 ms) was significantly less than PWD before and after OL-HDF (P < 0.001 and <0.001, respectively). Online HDF significantly decreased PWD and hence also the potential of AF development, which may invite a higher consideration of this renal replacement modality in a pediatric population.
authors: Department of Pediatrics, Cairo University, Cairo, Egypt.
authors: Happy
authors: H
authors: Sawires
authors: Department of Pediatrics, Cairo University, Cairo, Egypt.
authors: Samuel
authors: S
authors: Makar
authors: Department of Pediatrics, Cairo University, Cairo, Egypt.
authors: Hanan
authors: H
authors: Zekry
mesh_terms: D000293:Adolescent; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D002648:Child; D015331:Cohort Studies; D004534:Egypt / Q000453:epidemiology; D004562:Electrocardiography / Q000379:methods; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment / Q000379:methods
keywords: Atrial fibrillation; Diastolic dysfunction; End-stage renal disease; Online hemodiafiltration; P-wave dispersion