title: Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.
abstract: A series of 2-phenyl- or 3-phenyl piperazines, structurally related to DM235 and DM232, two potent nootropic agents, have been prepared and tested in the mouse passive-avoidance test, to assess their ability to revert scopolamine-induced amnesia. Although the newly synthesized molecules were less potent than the parent compounds, some useful information has been obtained from structure-activity relationships. A small but significant enantioselectivity has been found for the most potent compound 5a.
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Luca
authors: L
authors: Guandalini
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Maria Vittoria
authors: MV
authors: Martino
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmacology, Viale Pieraccini 6, 50100 Florence, Italy.
authors: Lorenzo
authors: L
authors: Di Cesare Mannelli
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Gianluca
authors: G
authors: Bartolucci
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Fabrizio
authors: F
authors: Melani
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Ruchi
authors: R
authors: Malik
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Silvia
authors: S
authors: Dei
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Elisa
authors: E
authors: Floriddia
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Dina
authors: D
authors: Manetti
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Francesca
authors: F
authors: Orlandi
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy.
authors: Elisabetta
authors: E
authors: Teodori
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmacology, Viale Pieraccini 6, 50100 Florence, Italy.
authors: Carla
authors: C
authors: Ghelardini
authors: Department of Neuroscience, Psychology, Drug Research and Child's Health, University of Florence, Section of Pharmaceutical and Nutraceutical Sciences, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy. Electronic address: novella.romanelli@unifi.it.
authors: Maria Novella
authors: MN
authors: Romanelli
mesh_terms: D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D051379:Mice; D018697:Nootropic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D011758:Pyrroles / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D018697:Nootropic Agents; D010879:Piperazines; D011758:Pyrroles; C416655:DM 235; C409868:DM 232
keywords: Cognition-enhancers; Mouse passive-avoidance test; Piperazines; Piracetam-like compounds; Sunifiram