title: Purinergic receptors in skeletal muscles in health and in muscular dystrophy.
abstract: The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways. Members of both groups have been identified in skeletal muscle cells at different stages of differentiation. It is well documented that sequential expression and down-regulation of particular P2 receptors on the surface of sarcolemma is closely associated with muscle maturation during embryogenesis and postnatal growth. P2 receptors are also involved in muscle regeneration following injury. Moreover, enhanced expression of specific purinergic receptors together with increased availability of extracellular ATP in dystrophic muscles are important elements of the dys- trophic pathophysiology considerably increasing severity.
authors: Elżbieta
authors: E
authors: Krasowska
authors: Justyna
authors: J
authors: Róg
authors: Anthony
authors: A
authors: Sinadinos
authors: Christopher N J
authors: CN
authors: Young
authors: Dariusz C
authors: DC
authors: Górecki
authors: Krzysztof
authors: K
authors: Zabłocki
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D002454:Cell Differentiation; D015536:Down-Regulation; D006801:Humans; D018482:Muscle, Skeletal / Q000196:embryology / Q000378:metabolism* / Q000473:pathology; D009136:Muscular Dystrophies / Q000378:metabolism* / Q000473:pathology; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D012508:Sarcolemma / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D018048:Receptors, Purinergic P2; D000255:Adenosine Triphosphate