title: Skin features in myotonic dystrophy type 1: an observational study.
abstract: Poor data regarding skin involvement in Myotonic Dystrophy, also named Dystrophia Myotonica type 1, have been reported. This study aimed to investigate the prevalence and types of skin disorders in adult patients with Myotonic Dystrophy type 1. Fifty-five patients and one hundred age- and sex-matched healthy subjects were referred to a trained dermatologist for a complete skin examination to check for potential cutaneous hallmarks of disease. No difference in prevalence of preneoplastic, neoplastic, and cutaneous lesions was detected between the two groups. Among morphofunctional, proliferative and inflammatory lesions, focal hyperhidrosis (p < 0.0001), follicular hyperkeratosis (p = 0.0003), early androgenic alopecia (p = 0.01), nail pitting (p = 0.003), pedunculus fibromas (p = 0. 01), twisted hair (p = 0.01), seborrheic dermatitis (p = 0.02), macules of hyperpigmentation (p = 0.03) were significantly more frequent in patients compared with controls. In patients with Myotonic Dystrophy type 1 significant differences according to sex were found for: early androgenic alopecia, twisted hair and seborrheic dermatitis, whose prevalence was higher in males (p < 0.0001). Our preliminary results seem to rule out an increased prevalence of pre-neoplastic, and neoplastic skin lesions in Myotonic Dystrophy type 1. On the other hand, an increased prevalence of morphofunctional, inflammatory, and proliferative diseases involving adnexal structures seems to characterize adult patients with Myotonic Dystrophy type 1.
authors: Dermatological Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy. Electronic address: anna.campanati@gmail.com.
authors: A
authors: A
authors: Campanati
authors: Dermatological Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
authors: M
authors: M
authors: Giannoni
authors: Neurological Clinic, Department of Neurosciences, Marche Polytechnic University, Ancona, Italy.
authors: L
authors: L
authors: Buratti
authors: Neurological Clinic, Department of Neurosciences, Marche Polytechnic University, Ancona, Italy.
authors: C
authors: C
authors: Cagnetti
authors: Dermatological Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
authors: K
authors: K
authors: Giuliodori
authors: Dermatological Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
authors: G
authors: G
authors: Ganzetti
authors: Neurological Clinic, Department of Neurosciences, Marche Polytechnic University, Ancona, Italy.
authors: M
authors: M
authors: Silvestrini
authors: Neurological Clinic, Department of Neurosciences, Marche Polytechnic University, Ancona, Italy.
authors: L
authors: L
authors: Provinciali
authors: Dermatological Clinic, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
authors: A
authors: A
authors: Offidani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009223:Myotonic Dystrophy / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D012871:Skin Diseases / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D055815:Young Adult
keywords: Cutaneous involvement; Dystrophia myotonica type 1; Myotonic dystrophy; Skin; Steinert's syndrome