title: Biosynthetic manipulation of tryptophan in bacteria: pathways and mechanisms.
abstract: Tryptophan, the most chemically complex and the least abundant of the 20 common proteinogenic amino acids, is a biosynthetic precursor to a large number of complex microbial natural products. Many of these molecules are promising scaffolds for drug discovery and development. The chemical features of tryptophan, including its ability to undergo enzymatic modifications at almost every atom in its structure and its propensity to undergo spontaneous, non-enzyme catalyzed chemistry, make it a unique biological precursor for the generation of chemical complexity. Here, we review the pathways that enable incorporation of tryptophan into complex metabolites in bacteria, with a focus on recently discovered, unusual metabolic transformations.
authors: Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada.
authors: Lona M
authors: LM
authors: Alkhalaf
authors: Department of Chemistry, University of British Columbia, Vancouver, BC, V6T 2K9, Canada. Electronic address: ksryan@chem.ubc.ca.
authors: Katherine S
authors: KS
authors: Ryan
mesh_terms: D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D014364:Tryptophan / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*
chemical_list: D014364:Tryptophan