title: Therapeutic effects of transdermal systems containing zinc-related materials on thermal burn rats.
abstract: OBJECTIVE
  The aim of the present study is to evaluate the efficacy of slow zinc (Zn) release from β-tricalcium phosphate powder (ZnTCP) containing 10 mol% Zn on rats with thermal burns.
  
  
  METHODS
  The first-aid tapes were contained zinc sulfate (ZnSO4) solution, ZnTCP suspensions or zinc oxide ointment. After thermal burn treatments were performed on Zn-deficient rats, the groups D1, D2 and D3 were treated with tapes containing ZnTCP, ZnSO4 and zinc oxide ointment. The effects of the tapes on wound area, plasma Zn levels and alkaline phosphatase activity (Alp) were investigated.
  
  
  RESULTS
  The wound area profiles of all rat groups could be separated into before and after the scab formation at around day 6. The area under the curve (Aw-AUC) for wound area profiles, therefore, was evaluated as an index of therapeutic scores for the thermal wound. The order of Aw-AUC was D3>C>D2>D1. The degree of expansion at the initial stage by thermal burns of group D1 was the lowest and that of group D2 was the highest, and the order was D1<D3<C<D2.
  
  
  CONCLUSIONS
  ZnTCP treatment could control the initial inflammation caused by thermal burns.
authors: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo, Japan.
authors: Makoto
authors: M
authors: Otsuka
authors: Kobe Pharmaceutical University, Higashi-Nada, Kobe, Japan.
authors: Haruna
authors: H
authors: Hatakeyama
authors: Kobe Pharmaceutical University, Higashi-Nada, Kobe, Japan.
authors: Masayuki
authors: M
authors: Shikamura
authors: Yokohama College of Pharmacy, Totsuka, Yokohama, Japan.
authors: Kuniko
authors: K
authors: Otsuka
authors: Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.
authors: Atsuo
authors: A
authors: Ito
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002056:Burns / Q000188:drug therapy*; D002130:Calcium Phosphates / Q000494:pharmacology*; D055598:Chemical Phenomena; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D005260:Female; D049329:Nanostructures / Q000737:chemistry; D009824:Ointments / Q000494:pharmacology; D011208:Powders / Q000737:chemistry; D051381:Rats; D044968:Regenerative Medicine; D014945:Wound Healing / Q000187:drug effects; D015032:Zinc / Q000097:blood / Q000493:pharmacokinetics; D015034:Zinc Oxide / Q000494:pharmacology*; D019287:Zinc Sulfate / Q000494:pharmacology*
chemical_list: D002130:Calcium Phosphates; D009824:Ointments; D011208:Powders; C485817:beta-tricalcium phosphate; D019287:Zinc Sulfate; D000469:Alkaline Phosphatase; D015032:Zinc; D015034:Zinc Oxide
keywords: Transdermal therapeutic system; healing process; in vivo zinc release; thermal burns; tricalcium phosphate containing zinc; wounded area