title: Unusual presentation of pelizaeus-merzbacher disease: female patient with deletion of the proteolipid protein 1 gene.
abstract: Pelizaeus-Merzbacher disease (PMD) is neurodegenerative leukodystrophy caused by dysfunction of the proteolipid protein 1 (PLP1) gene on Xq22, which codes for an essential myelin protein. As an X-linked condition, PMD primarily affects males; however there have been a small number of affected females reported in the medical literature with a variety of different mutations in this gene. No affected females to date have a deletion like our patient. In addition to this, our patient has skewed X chromosome inactivation which adds to her presentation as her unaffected mother also carries the mutation.
authors: Silicon Valley Genetics Center, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.
authors: Teva
authors: T
authors: Brender
authors: Silicon Valley Genetics Center, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.
authors: Donna
authors: D
authors: Wallerstein
authors: Silicon Valley Genetics Center, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.
authors: John
authors: J
authors: Sum
authors: Silicon Valley Genetics Center, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.
authors: Robert
authors: R
authors: Wallerstein