title: Phosphorylation of lamins determine their structural properties and signaling functions.
abstract: Lamin A/C is part of the nuclear lamina, a meshwork of intermediate filaments underlying the inner nuclear membrane. The lamin network is anchoring a complex set of structural and linker proteins and is either directly or through partner proteins also associated or interacting with a number of signaling protein and transcription factors. During mitosis the nuclear lamina is dissociated by well established phosphorylation- dependent mechanisms. A-type lamins are, however, also phosphorylated during interphase. A recent study identified 20 interphase phosphorylation sites on lamin A/C and explored their functions related to lamin dynamics; movements, localization and solubility. Here we discuss these findings in the light of lamin functions in health and disease.
authors: a Department of Biosciences; Åbo Akademi University ; Turku , Finland.
authors: Elin
authors: E
authors: Torvaldson
authors: Vitaly
authors: V
authors: Kochin
authors: John E
authors: JE
authors: Eriksson
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D007382:Intermediate Filaments / Q000737:chemistry / Q000378:metabolism; D007399:Interphase / Q000235:genetics*; D034904:Lamin Type A / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008938:Mitosis; D020389:Muscular Dystrophy, Emery-Dreifuss / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D034881:Nuclear Lamina / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D021381:Protein Transport; D015398:Signal Transduction; D012995:Solubility
chemical_list: C494847:LMNA protein, human; D034904:Lamin Type A
keywords: EDMD, Emery-Dreifuss muscular dystrophy; GFP, green fluorescent protein; IFs, intermediate filaments; LAP2α, Lamina-associated polypeptide 2 isoform α; intermediate filaments; lamin A/C; laminopathy; lamins; phosphorylation; signaling