title: Using bioluminescence imaging in glioma research.
abstract: Glioblastoma multiforme (GBM) is the most common malignant brain tumour and has the worst prognosis. Over the last decade, the use of bioluminescence imaging technology has rapidly become widespread to further understand the mechanisms that drive GBM development and progression. Pre-clinical evaluation and optimisation of therapeutic efficacy in GBM research has also utilised this simple non-invasive technology. Here we summarise recent advances made in glioma biology and therapeutic intervention using bioluminescence imaging. This review also describes the current knowledge regarding the use of luciferase-based reporters in examining the role of specific cancer signalling cascades that promote glioma progression.
authors: Department of Surgery, Level 5, Clinical Sciences Building, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia. Electronic address: rluwor@unimelb.edu.au.
authors: Rodney B
authors: RB
authors: Luwor
authors: Department of Surgery, Level 5, Clinical Sciences Building, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors: Stanley S
authors: SS
authors: Stylli
authors: Department of Surgery, Level 5, Clinical Sciences Building, The University of Melbourne, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia; Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors: Andrew H
authors: AH
authors: Kaye
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000379:methods*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D005909:Glioblastoma / Q000175:diagnosis / Q000628:therapy; D005910:Glioma / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*
keywords: Bioluminescence; Glioblastoma multiforme; Signalling; Therapy