title: [Birth of a child with Down syndrome: parental choice or failure of screening policy?].
abstract: OBJECTIVE
  Birth of a child with Down syndrome (DS) can follow parental choice or failure of screening. The objective of this work is to describe the circumstances of births of children with DS in a French perinatal health network.
  
  
  METHODS
  Retrospective multicentric study, with prospective trial registration of all children born alive with DS, between 2010 and 2013.
  
  
  RESULTS
  Sixty-three children were born with DS. Complete screening was performed by 61 % of patients, incomplete screening by 29 % of patients and no screening test by 10 %. Among these births, 50 % occurred following parental choice, 40 % following failure of screening and for 10 %, parental choice concerning screening was unknown. False negative had often calculating risk close to 1/1000.
  
  
  CONCLUSIONS
  In this study, the birth of a child with DS occurred following parental choice in half of cases. It's necessary, to optimize the follow-up, to document in medical records the medical information and parental choice concerning DS screening and data of screening when this was done.
authors: Pôle d'obstétrique, CHRU de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France. Electronic address: marxaurore@gmail.com.
authors: A
authors: A
authors: Marx-Deseure
authors: Réseau de santé en périnatalité OMBREL, CHRU de Lille, hôpital Jeanne-de-Flandre, 59037 Lille cedex, France.
authors: S
authors: S
authors: Carpentier
authors: Pôle pédiatrie, CHRU de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors: D
authors: D
authors: Thomas
authors: Pôle de biopathologie, laboratoire de cytogénétique, CHRU de Lille, 59037 Lille cedex, France.
authors: S
authors: S
authors: Bouquillon
authors: Laboratoire de génétique, hôpital Saint-Vincent-de-Paul, 59020 Lille, France.
authors: B
authors: B
authors: Delobel
authors: Réseau de santé en périnatalité OMBREL, CHRU de Lille, hôpital Jeanne-de-Flandre, 59037 Lille cedex, France.
authors: B
authors: B
authors: Bailleux
authors: Réseau de santé en périnatalité OMBREL, CHRU de Lille, hôpital Jeanne-de-Flandre, 59037 Lille cedex, France.
authors: H
authors: H
authors: Bomy
authors: Pôle d'obstétrique, CHRU de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors: P
authors: P
authors: Vaast
authors: Pôle d'obstétrique, CHRU de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France; Université de Lille 2, 59000 Nord de France, France.
authors: V
authors: V
authors: Debarge
mesh_terms: D000328:Adult; D002755:Choice Behavior; D004314:Down Syndrome / Q000175:diagnosis*; D005188:False Negative Reactions; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D010290:Parents / Q000523:psychology*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000523:psychology* / Q000592:standards*; D011446:Prospective Studies; D012189:Retrospective Studies
keywords: Choix parental; Down syndrome; Failure of screening; Malformations; Parental choice; Trisomie 21; Échec de dépistage