title: Generation mechanism of hydroxyl radical species and its lifetime prediction during the plasma-initiated ultraviolet (UV) photolysis.
abstract: Through this work, we have elucidated the mechanism of hydroxyl radicals (OH(•)) generation and its life time measurements in biosolution. We observed that plasma-initiated ultraviolet (UV) photolysis were responsible for the continues generation of OH(•) species, that resulted in OH(•) to be major reactive species (RS) in the solution. The density and lifetime of OH(•) species acted inversely proportional to each other with increasing depth inside the solution. The cause of increased lifetime of OH(•) inside the solution is predicted using theoretical and semiempirical calculations. Further, to predict the mechanism of conversion of hydroxide ion (OH(-)) to OH(•) or H2O2 (hydrogen peroxide) and electron, we determined the current inside the solution of different pH. Additionally, we have investigated the critical criterion for OH(•) interaction on cancer cell inducing apoptosis under effective OH(•) exposure time. These studies are innovative in the field of plasma chemistry and medicine.
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Pankaj
authors: P
authors: Attri
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Yong Hee
authors: YH
authors: Kim
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Dae Hoon
authors: DH
authors: Park
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Ji Hoon
authors: JH
authors: Park
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Young J
authors: YJ
authors: Hong
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Han Sup
authors: HS
authors: Uhm
authors: Yonsei University, Seoul, Korea.
authors: Kyoung-Nam
authors: KN
authors: Kim
authors: Drexel Plasma Institute, Drexel University, PA, USA.
authors: Alexander
authors: A
authors: Fridman
authors: Plasma Bioscience Research Center, Kwangwoon University, Seoul, Korea.
authors: Eun Ha
authors: EH
authors: Choi
mesh_terms: D006861:Hydrogen Peroxide / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry*; D010782:Photolysis; D058626:Plasma Gases; D014466:Ultraviolet Rays
chemical_list: D058626:Plasma Gases; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide