title: Comparative bone tissue integration of nanostructured and microroughened dental implants.
abstract: OBJECTIVE
  The aim was to compare osteointegration of nanostructured implants to a microsurface widely used for titanium dental implants.
  
  
  METHODS
  Commercial titanium dental implants with smooth or microroughened surfaces were nanostructured. Implants were inserted into the femoral condyles of rabbits. After 2 and 4 weeks, histomorphometry calculation was performed.
  
  
  RESULTS
  Nanotubes measuring 60 nm in diameter were observed on both S-NANO (roughness: 0.05 μm) and R-NANO (roughness: 0.40 μm) surfaces. The MICRO surface exhibited typical random cavities (roughness: 2.09 μm). At 4 weeks, bone-to-implant contact values were significantly higher for the R-NANO than for the MICRO surface while no differences were observed at 2 weeks.
  
  
  CONCLUSIONS
  Overall, this study shows that the nanostructured surfaces improved osteointegration similar or higher than the MICRO.
authors: Inserm U957, Lab. Pathophysiology of Bone Resorption, Faculty of Medicine, University of Nantes, France.
authors: Laëtitia
authors: L
authors: Salou
authors: Alain
authors: A
authors: Hoornaert
authors: Julien
authors: J
authors: Stanovici
authors: Sylvain
authors: S
authors: Briand
authors: Guy
authors: G
authors: Louarn
authors: Pierre
authors: P
authors: Layrolle
mesh_terms: D000818:Animals; D015921:Dental Implants; D005260:Female; D005269:Femur / Q000601:surgery; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D050997:Nanomedicine; D049329:Nanostructures; D043942:Nanotubes; D016348:Osseointegration; D011474:Prosthesis Design; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium
keywords: bone-to-implant contact; dental implant; nanostructure; osseointegration; titanium