title: Successful treatment with sirolimus for an angiomyolipoma mimicking renal cell carcinoma in a transplanted kidney.
abstract: Angiomyolipoma (AML) is a benign mesenchymal tumor composed of blood vessels, smooth muscle, and mature adipose tissue. AMLs in the kidney allografts are rare. We report a case of AML that was incidentally found 1 year after transplantation. Abdominal computed tomography showed a 4-cm renal tumor with contrast enhancement and an early washout pattern, resembling a renal cell carcinoma. Tumor biopsy proved a lipid-poor AML. Tumor diameter decreased to 2.4 cm after 6 months of treatment with sirolimus. Sirolimus not only reduces tumor size, but also benefits a transplant patient who needs immunosuppression.
authors: Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Hsien-Fu
authors: HF
authors: Chiu
authors: Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Mei-Chin
authors: MC
authors: Wen
authors: Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Jian-Ri
authors: JR
authors: Li
authors: Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
authors: Hao-Chung
authors: HC
authors: Ho
authors: Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Kuo-Hsiung
authors: KH
authors: Shu
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000150:complications / Q000188:drug therapy*; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications / Q000188:drug therapy*; D016030:Kidney Transplantation / Q000009:adverse effects*; D009392:Nephrectomy; D051437:Renal Insufficiency / Q000150:complications / Q000601:surgery*; D020123:Sirolimus / Q000627:therapeutic use*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus
keywords: angiomyolipoma; mammalian target of rapamycin inhibitor; renal cell carcinoma; renal transplantation