title: Clinicopathologic features of chronic nonspecific multiple ulcers of the small intestine.
abstract: Chronic nonspecific multiple ulcers of the small intestine is a rare but distinct clinical condition, characterized by multiple small intestinal ulcers of nonspecific histology and chronic, persistent gastrointestinal bleeding without nonsteroidal anti-inflammatory drug use. However, because of the term "nonspecific" in its nomenclature, some gastroenterologists have misinterpreted the disease as the condition with small intestinal ulcers caused by undetermined etiologies without considering clinical features. Such misinterpretation has led to the heterogeneity of clinicopathologic features of the disease, as well as to ambiguity regarding a possible genetic contribution. It thus seems necessary to recognize the clinical entity of the disease precisely to avoid misinterpretation. In this review, we describe the clinicopathologic features, differential diagnosis, and the possibility of a genetic contribution to the disease.
authors: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan, mesaki@intmed2.med.kyushu-u.ac.jp.
authors: Motohiro
authors: M
authors: Esaki
authors: Junji
authors: J
authors: Umeno
authors: Takanari
authors: T
authors: Kitazono
authors: Takayuki
authors: T
authors: Matsumoto
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014456:Ulcer / Q000175:diagnosis / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D055815:Young Adult