title: Usefulness of dual-phase 18F-FDG PET/CT for diagnosing small pancreatic tumors.
abstract: OBJECTIVE
  The usefulness of dual-phase F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for pancreatic tumors was investigated including numerous small tumors.
  
  
  METHODS
  Consecutive 116 patients with solid pancreatic tumors were subjected. Maximum standard uptake values (SUVmax) at 1 and 2 hours after FDG injection were defined as early and delayed SUVmax, respectively. Receiver operating characteristic curve was used to determine the optimal cutoff value of early SUVmax. Diagnostic accuracy of dual-phase FDG PET/CT was compared with that of single phase.
  
  
  RESULTS
  The mean ± SD tumor size was 25 ±12 mm in diameter. The level of early SUVmax and proportion of elevated SUVmax in delayed phase were significantly higher in malignancy than those in benignancy for less than 25 mm tumors (4.1 ± 2.6 vs 1.9 ± 0.5, P < 0.001; 89% vs 17%, P < 0.0001) although they did not reach statistical significance for greater than or equal to 25 mm tumors. When diagnostic criteria of dual-phase FDG PET/CT for less than 25 mm tumors were determined as (1) early SUVmax greater than or equal to 2.1 and/or (2) delayed SUVmax greater than early SUVmax, sensitivity, specificity, and over all accuracy of dual-phase FDG PET/CT were better than that of single phase for less than 25 mm tumor (93%, 83%, and 91% vs 79%, 83%, and 80%, respectively).
  
  
  CONCLUSIONS
  Dual-phase FDG PET/CT might be useful for diagnosing small pancreatic tumors.
authors: From the *Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka; †Department of Gastroenterology, Kanazawa Medical University, Ishikawa; ‡Department of Gastroenterology, Osaka Medical Center for Cancer and Cardiovascular Diseases; and §Morinomiya Clinic PET Center, Osaka, Japan.
authors: Natsuko
authors: N
authors: Kawada
authors: Hiroyuki
authors: H
authors: Uehara
authors: Takuya
authors: T
authors: Hosoki
authors: Motohisa
authors: M
authors: Takami
authors: Hisakazu
authors: H
authors: Shiroeda
authors: Tomiyasu
authors: T
authors: Arisawa
authors: Yasuhiko
authors: Y
authors: Tomita
mesh_terms: D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods*; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18