title: [Miliary cerebral carcinomatosis secondary to EGFR mutation-positive lung adenocarcinoma].
abstract: BACKGROUND
  Miliary brain metastases are a rare form of brain metastatic lesions.
  
  
  METHODS
  We report the case of a 58-year-old patient with lung adenocarcinoma and an EGFR mutation, who had metastatic lesions in the bones, pleura and pericardia at the time of diagnosis. The patient was treated with tyrosine kinase inhibitor. A few months later, he presented with progressive neuropsychiatric symptoms, which were attributed to miliary brain metastases based on the radiological pattern (micronodules, some of which were calcified) and the elimination of alternative possible diagnoses. Despite tumour stability in the thorax and metastatic sites other than the brain, his neurological condition deteriorated, even after cerebral radiotherapy, leading to his death eight months after the diagnosis of lung cancer.
  
  
  CONCLUSIONS
  Miliary brain metastases are a rare form of brain metastases with unusual clinical presentation. The diagnosis is based on the radiological pattern of cerebral miliary dissemination, with sometimes calcified tumor nodules. Despite its rarity, several cases have been reported in lung adenocarcinoma in the presence of EGFR mutations.
authors: Service de pneumologie et d'oncologie thoracique, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France. Electronic address: jennifer.dumoulin@apr.aphp.fr.
authors: J
authors: J
authors: Dumoulin
authors: Service de pneumologie et d'oncologie thoracique, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
authors: N
authors: N
authors: Rozensztajn
authors: Équipe de liaison et de soins en addictologie et psychiatrie de liaison, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France.
authors: M
authors: M
authors: Paradis
authors: Service de radiologie, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France.
authors: J
authors: J
authors: Sellier
authors: Service de soins palliatifs, hôpital Ambroise-Paré, AP-HP, 92100 Boulogne-Billancourt, France.
authors: A
authors: A
authors: Abel
authors: Service d'oncologie radiothérapie, hôpital européen Georges-Pompidou, AP-HP, 75015 Paris, France.
authors: P
authors: P
authors: Giraud
authors: Service de pneumologie et d'oncologie thoracique, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
authors: S
authors: S
authors: Labrune
authors: Service de pneumologie et d'oncologie thoracique, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.
authors: T
authors: T
authors: Chinet
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D001932:Brain Neoplasms / Q000235:genetics* / Q000556:secondary; D002277:Carcinoma / Q000235:genetics* / Q000556:secondary; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation
chemical_list: D066246:ErbB Receptors
keywords: Adénocarcinome bronchique; Brain metastases; Carcinomatous encephalitis; Encéphalite carcinomateuse; Epidermal growth factor receptor; Lung adenocarcinoma; Miliaire cérébrale carcinomateuse; Miliary brain metastases; Métastases cérébrales; Récepteur du facteur de croissance épidermique