title: [The Ehlers-Danlos syndrome: hystory of a clinical hendiadys].
abstract: Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterized by joint hypermobility, skin hyperextensibility and tissue fragility, which results in easy bruising and abnormal scarring. The condition shows a phenotypic variance from milder to serious presentations. Complaints related to activity (hypermobility, dislocations, impaired balance), to pain (general pain, headache, jaw and tooth pain) and to skin (bruises, fragility, impaired wound healing) are frequent. It was first noted by Hippocrates in 400 BC in his writing 'Airs Water and Places' that the nomads Scythians had lax joints and multiple scars. Whereas the additional flexibility can give benefits in term of mobility and agility, adverse effects of tissue laxity and fragility can give rise to clinical consequences. We recognize that it is important that, in those hypermobility patients, who develop potentially debilitating symptoms of chronicfatigue or widespread pain, there should be prompt an appropriate intervention.
authors: Dipartimento di Medicina Fisica e Riabilitativa, Policlinico Umberto I, "La Sapienza" Universitià di Roma, I.
authors: Cristina
authors: C
authors: Brazzaventre
authors: Claudia
authors: C
authors: Celletti
authors: Paolo
authors: P
authors: Gobattoni
authors: Valter
authors: V
authors: Santilli
authors: Filippo
authors: F
authors: Camerota
mesh_terms: D004535:Ehlers-Danlos Syndrome / Q000235:genetics / Q000266:history* / Q000503:physiopathology; D005060:Europe; D018645:Greek World; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049690:History, Ancient