title: Role of Ki-67 in acromegalic patients with hyperprolactinemia: retrospective analysis in 61 Chinese Patients.
abstract: To evaluate the specific characteristics in acromegalic patients with hyperprolactinemia by analyzing the differences between patients with different Ki-67 values. Between 2002 and 2010, a set of data on 61 patients undergoing transsphenoidal surgery was available at the Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University. Patients were divided into Ki-67 >3% group and <3% group. A retrospective analysis of clinical, hormonal, immunohistochemical, and imaging was observed in all patients. There were no significant differences in age, gender, tumor size and apoplexy between the two groups. Time interval in Ki-67 ≥3% group was longer than <3% group (P=0.037). Patients in Ki-67 >3% group had a higher rate of invasiveness (P=0.048), higher incidences of diabetes mellitus (P=0.036), coarse facial features (P=0.048), large hands and feet (P=0.003), higher GH levels (P<0.05), higher diabetes insipidus rate (P<0.001), and more frequent recurrence (P=0.011) than Ki-67 <3% group. Patients with higher Ki-67 value harbored longer time interval, more aggressive tumors, more acromegaly manifestations, higher GH level, and higher recurrence than patients with lower Ki-67 value.
authors: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors: Cheng
authors: C
authors: Huan
authors: Department of Outpatient, Yidu Central Hospital of Weifang, China.
authors: Guihua
authors: G
authors: Cui
authors: Department of Laboratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, China.
authors: Chao
authors: C
authors: Lu
authors: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors: Xin
authors: X
authors: Qu
authors: Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors: Tao
authors: T
authors: Han
mesh_terms: D000172:Acromegaly / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D000236:Adenoma / Q000097:blood / Q000737:chemistry* / Q000150:complications / Q000473:pathology / Q000601:surgery; D000328:Adult; D002681:China; D005260:Female; D049912:Growth Hormone-Secreting Pituitary Adenoma / Q000097:blood / Q000737:chemistry* / Q000150:complications / Q000473:pathology / Q000601:surgery; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000737:chemistry* / Q000150:complications / Q000473:pathology / Q000601:surgery; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000737:chemistry* / Q000150:complications / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen; D019382:Human Growth Hormone; D011388:Prolactin