title: Rapid resolution of retinoschisis with acetazolamide.
abstract: OBJECTIVE
  To report the results of an acetazolamide (Diamox(®)) treatment regimen in a genetically confirmed case of X-linked juvenile retinoschisis (XLRS).
  
  
  METHODS
  A patient with XLRS was prescribed acetazolamide (Diamox(®)) at a dose of 500 mg/day, then discontinued the treatment due to non-compliance for 4 days, and finally resumed the course of treatment. Best-corrected visual acuity, retinal structure, and function were monitored with autofluorescence, spectral domain-optical coherence tomography (SD-OCT), adaptive optics scanning laser ophthalmoscopy (AOSLO), and full-field electroretinogram (ERG). Full-field ERG was performed using DTL recording electrodes and Ganzfeld stimulation according to ISCEV standards.
  
  
  RESULTS
  Serial monitoring of the cysts by SD-OCT revealed a strong association between the effects of acetazolamide administration and the size of the schisis. A reduction in foveal cyst size was significant in as rapid as 6 days after acetazolamide initiation. AOSLO data revealed that the resolution of cone cell images improves as the foveal schisis decreases in size.
  
  
  CONCLUSIONS
  Efficacy of acetazolamide in patients with XLRS can be apparent in as rapid as a week of therapy. AOSLO can be a good method to evaluate the cone cells after acetazolamide treatment in the early stages of XLRS.
authors: Barbara and Donald Jonas Laboratory of Stem Cell and Regenerative Medicine, Department of Ophthalmology, Columbia University, New York, NY, USA.
authors: Lijuan
authors: L
authors: Zhang
authors: Roberto
authors: R
authors: Reyes
authors: Winston
authors: W
authors: Lee
authors: Ching-Lung
authors: CL
authors: Chen
authors: Lawrence
authors: L
authors: Chan
authors: Tharikarn
authors: T
authors: Sujirakul
authors: Stanley
authors: S
authors: Chang
authors: Stephen H
authors: SH
authors: Tsang
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D004596:Electroretinography; D006801:Humans; D008297:Male; D009887:Ophthalmoscopy; D012160:Retina / Q000503:physiopathology; D041441:Retinoschisis / Q000188:drug therapy* / Q000503:physiopathology; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide