title: Early Diagnosis of Subclinical Interferon Alpha-Associated Optic Neuropathy Using Fluorescein Angiography.
abstract: We report a case of a 57-year-old man who presented with decreased visual acuity in the left eye secondary to nonarteritic anterior ischemic optic neuropathy (NAION) while on therapy with interferon-α for hepatitis C. Fundus fluorescein angiography revealed late leakage of both optic discs, consistent with bilateral disease. One week later, the patient developed clinical signs and symptoms consistent with NAION in the fellow eye. Fluorescein angiography may play an important role in identifying subclinical NAION in patients taking interferon-α.
authors: Neuro-Ophthalmology Service (DMC, SL, DM), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and the Department of Ophthalmology and Visual Science (DM), Havener Eye Institute, The Ohio State University, Wexner Medical Center, Columbus, Ohio.
authors: Dean M
authors: DM
authors: Cestari
authors: Simmons
authors: S
authors: Lessell
authors: Dimosthenis
authors: D
authors: Mantopoulos
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D042241:Early Diagnosis; D005451:Fluorescein Angiography; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D002097:C-Reactive Protein