title: [Association of ORMDL3 single nucleotide polymorphisms with lysophosphatidylcholine and apolipoprotein B levels in children with asthma].
abstract: OBJECTIVE
  To study the association of ORMDL3 single nucleotide polymorphisms (SNP) with lysophosphatidylcholine (LysoPC) and apolipoprotein B (apoB) levels.
  
  
  METHODS
  A total of 300 children diagnosed with bronchial asthma between January 2010 and December 2012 were selected for the asthma group, and 298 children diagnosed with upper respiratory tract infection in the same period were selected for the control group. Serum LysoPC and apoB levels were measured using enzyme-linked immunosorbent assay. Genotype analysis was performed using the TaqMan probe.
  
  
  RESULTS
  LysoPC and apoB levels were significantly higher in the asthma group than in the control group (P<0.01). Among children with various genotypes of ORMDL3 gene at locus rs12603332, the asthma group had significantly higher LysoPC and apoB levels than the control group (P<0.01). Among the children with asthma, those with CC genotype had significantly higher LysoPC and apoB levels than those with CT and TT genotypes (P<0.01).
  
  
  CONCLUSIONS
  LysoPC and apoB may intervene in the pathological process of asthma. Pro-inflammatory gene ORMDL3 SNP rs12603332 may be associated with high LysoPC and apoB levels, which leads to the occurrence of childhood asthma.
authors: Department of Pediatric Respiratory Medicine, Zhongshan Boai Hospital of Southern Medical University, Zhongshan, Guangdong 528400, China. 53046697@qq.com.
authors: Bing-Jie
authors: BJ
authors: Wang
authors: Gui-Lan
authors: GL
authors: Wang
authors: De-Hui
authors: DH
authors: Chen
authors: Wen-Xiang
authors: WX
authors: Wang
authors: Juan
authors: J
authors: Huang
authors: Jia-Yan
authors: JY
authors: Rong
authors: Xiang-Teng
authors: XT
authors: Liu
authors: Sai
authors: S
authors: Yang
mesh_terms: D001055:Apolipoproteins B / Q000097:blood*; D001249:Asthma / Q000097:blood / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008244:Lysophosphatidylcholines / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D001055:Apolipoproteins B; D008244:Lysophosphatidylcholines; D008565:Membrane Proteins; C464399:ORMDL3 protein, human