title: Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network.
abstract: OBJECTIVE
  To examine the feasibility of deploying a virtual web service for sharing data within a research network, and to evaluate the impact on data consistency and quality.
  
  
  METHODS
  Virtual machines (VMs) encapsulated an open-source, semantically and syntactically interoperable secure web service infrastructure along with a shadow database. The VMs were deployed to 8 Collaborative Pediatric Critical Care Research Network Clinical Centers.
  
  
  RESULTS
  Virtual web services could be deployed in hours. The interoperability of the web services reduced format misalignment from 56% to 1% and demonstrated that 99% of the data consistently transferred using the data dictionary and 1% needed human curation.
  
  
  CONCLUSIONS
  Use of virtualized open-source secure web service technology could enable direct electronic abstraction of data from hospital databases for research purposes.
authors: Biomedical Informatics Center, Department Public Health Sciences, Medical University of South Carolina, Charleston, USA frey@musc.edu.
authors: Lewis J
authors: LJ
authors: Frey
authors: College of Nursing; Department of Biomedical Informatics, University of Utah, Salt Lake City, USA.
authors: Katherine A
authors: KA
authors: Sward
authors: USC Keck School of Medicine; Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
authors: Christopher J L
authors: CJ
authors: Newth
authors: USC Keck School of Medicine; Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, USA.
authors: Robinder G
authors: RG
authors: Khemani
authors: Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, USA.
authors: Martin E
authors: ME
authors: Cryer
authors: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.
authors: Julie L
authors: JL
authors: Thelen
authors: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.
authors: Rene
authors: R
authors: Enriquez
authors: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, USA.
authors: Su
authors: S
authors: Shaoyu
authors: Phoenix Children's Hospital, Department of Pediatrics, University of Arizona Phoenix, Phoenix, USA.
authors: Murray M
authors: MM
authors: Pollack
authors: Department of Pediatrics, University of California at Los Angeles, Los Angeles, USA.
authors: Rick E
authors: RE
authors: Harrison
authors: Department of Pediatrics, Children's Hospital of Michigan, Detroit, USA.
authors: Kathleen L
authors: KL
authors: Meert
authors: Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
authors: Robert A
authors: RA
authors: Berg
authors: Department of Pediatrics, Children's National Medical Center, Washington, DC, USA.
authors: David L
authors: DL
authors: Wessel
authors: Department of Pediatrics, University of Michigan, Ann Arbor, USA.
authors: Thomas P
authors: TP
authors: Shanley
authors: Department of Child Health, Phoenix Children's Hospital, University of Arizona College of Medicine-Phoenix, Phoenix, USA.
authors: Heidi
authors: H
authors: Dalton
authors: Department of Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, USA.
authors: Joseph
authors: J
authors: Carcillo
authors: Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, USA.
authors: Tammara L
authors: TL
authors: Jenkins
authors: Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Utah School of Medicine; NICHD Collaborative Pediatric Critical Care Research Network, Salt Lake City, USA.
authors: J Michael
authors: JM
authors: Dean
mesh_terms: D022126:Access to Information; D003195:Computer Communication Networks; D003199:Computer Systems; D003422:Critical Care; D019992:Databases as Topic; D005240:Feasibility Studies; D006801:Humans; D033181:Information Dissemination / Q000379:methods*; D020407:Internet; D010372:Pediatrics / Q000458:organization & administration*; D012984:Software
keywords: data governance; electronic health record; grid; learning health care system; pediatric critical care; pediatric network; secure web services; virtual machines; virtualization