title: [Determination of the concentration of platelet serotonin for the prediction of the two-wave course of tick-borne encephalitis].
abstract: The paper gives the results of an investigation of platelet serotonin levels in patients with tick-borne encephalitis to determine a criterion for predicting the development of its to-wave course. Fifty-five patients were examined at the height of tick-borne encephalitis (in the first 2-4 days): Group 1 included 39 patients with a one-wave course of the disease; Group 2 consisted of 16 patients with its two-wave course. Platelet serotonin concentrations were determined by enzyme immunoassay. Analysis of platelet serotonin levels could establish its lower value in the two-wave course (115.6 ± 36.2 ng/ml) than in the one-wave one (261.9 ± 96.8 ng/ml; p < 0.001). The significant difference between these types of tick-borne encephalitis and the calculation of the optimal cutoff value could propose this indicator as a predictor to detect the second wave of the infection.
authors: O N
authors: ON
authors: Sumlivaia
authors: N N
authors: NN
authors: Vorob'eva
authors: Iu V
authors: IuV
authors: Karakulova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets; D004669:Encephalitis Viruses, Tick-Borne / Q000302:isolation & purification / Q000472:pathogenicity*; D004675:Encephalitis, Tick-Borne / Q000097:blood* / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
chemical_list: D012701:Serotonin