title: Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy.
abstract: In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.
authors: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou 350002, P. R. China. lijuanfzu@gmail.com.
authors: Kaimei
authors: K
authors: Ke
authors: Lisen
authors: L
authors: Lin
authors: Hong
authors: H
authors: Liang
authors: Xian
authors: X
authors: Chen
authors: Chao
authors: C
authors: Han
authors: Juan
authors: J
authors: Li
authors: Huang-Hao
authors: HH
authors: Yang
mesh_terms: D000327:Adsorption; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods*; D002417:Cattle; D002470:Cell Survival; D042541:Intracellular Space / Q000378:metabolism*; D061986:MCF-7 Cells; D053758:Nanoparticles; D010789:Phototherapy / Q000379:methods*; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use*; D011758:Pyrroles / Q000737:chemistry* / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D011108:Polymers; D011758:Pyrroles; D012333:RNA, Messenger; D012710:Serum Albumin, Bovine; C067635:polypyrrole