title: Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa.
abstract: Fruit bats are suspected to be a natural reservoir of filoviruses, including Ebola and Marburg viruses. Using an enzyme-linked immunosorbent assay based on the viral glycoprotein antigens, we detected filovirus-specific immunoglobulin G antibodies in 71 of 748 serum samples collected from migratory fruit bats (Eidolon helvum) in Zambia during 2006-2013. Although antibodies to African filoviruses (eg, Zaire ebolavirus) were most prevalent, some serum samples showed distinct specificity for Reston ebolavirus, which that has thus far been found only in Asia. Interestingly, the transition of filovirus species causing outbreaks in Central and West Africa during 2005-2014 seemed to be synchronized with the change of the serologically dominant virus species in these bats. These data suggest the introduction of multiple species of filoviruses in the migratory bat population and point to the need for continued surveillance of filovirus infection of wild animals in sub-Saharan Africa, including hitherto nonendemic countries.
authors: Hokudai Center for Zoonosis Control in Zambia Departments of Disease Control.
authors: Hirohito
authors: H
authors: Ogawa
authors: Divisions of Global Epidemiology.
authors: Hiroko
authors: H
authors: Miyamoto
authors: Divisions of Global Epidemiology.
authors: Eri
authors: E
authors: Nakayama
authors: Divisions of Global Epidemiology.
authors: Reiko
authors: R
authors: Yoshida
authors: Departments of Disease Control Collaboration and Education.
authors: Ichiro
authors: I
authors: Nakamura
authors: Departments of Disease Control Molecular Pathobiology Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Hirofumi
authors: H
authors: Sawa
authors: Hokudai Center for Zoonosis Control in Zambia Departments of Disease Control.
authors: Akihiro
authors: A
authors: Ishii
authors: Hokudai Center for Zoonosis Control in Zambia Departments of Disease Control.
authors: Yuka
authors: Y
authors: Thomas
authors: Hokudai Center for Zoonosis Control in Zambia Departments of Disease Control.
authors: Emiko
authors: E
authors: Nakagawa
authors: Divisions of Global Epidemiology Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Keita
authors: K
authors: Matsuno
authors: Divisions of Global Epidemiology.
authors: Masahiro
authors: M
authors: Kajihara
authors: Divisions of Global Epidemiology.
authors: Junki
authors: J
authors: Maruyama
authors: Divisions of Global Epidemiology.
authors: Naganori
authors: N
authors: Nao
authors: Divisions of Global Epidemiology.
authors: Mieko
authors: M
authors: Muramatsu
authors: Divisions of Global Epidemiology.
authors: Makoto
authors: M
authors: Kuroda
authors: Departments of Disease Control.
authors: Edgar
authors: E
authors: Simulundu
authors: Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka Southern African Centre for Infectious Disease Surveillance, Chuo Kikuu, Morogoro, Tanzania.
authors: Katendi
authors: K
authors: Changula
authors: Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka Southern African Centre for Infectious Disease Surveillance, Chuo Kikuu, Morogoro, Tanzania.
authors: Bernard
authors: B
authors: Hang'ombe
authors: Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka.
authors: Boniface
authors: B
authors: Namangala
authors: Departments of Disease Control.
authors: Andrew
authors: A
authors: Nambota
authors: Zambia Wildlife Authority, Chilanga.
authors: Jackson
authors: J
authors: Katampi
authors: Divisions of Global Epidemiology Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Manabu
authors: M
authors: Igarashi
authors: Bioinformatics, Research Center for Zoonosis Control Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Kimihito
authors: K
authors: Ito
authors: Laboratory of Virology, Division of Intramural Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
authors: Heinz
authors: H
authors: Feldmann
authors: Departments of Disease Control Collaboration and Education Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Chihiro
authors: C
authors: Sugimoto
authors: Hokudai Center for Zoonosis Control in Zambia Paraclinical Studies, School of Veterinary Medicine, University of Zambia, Lusaka.
authors: Ladslav
authors: L
authors: Moonga
authors: Departments of Disease Control Southern African Centre for Infectious Disease Surveillance, Chuo Kikuu, Morogoro, Tanzania.
authors: Aaron
authors: A
authors: Mweene
authors: Departments of Disease Control Divisions of Global Epidemiology Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors: Ayato
authors: A
authors: Takada
mesh_terms: D000349:Africa / Q000453:epidemiology; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001208:Asia / Q000453:epidemiology; D002460:Cell Line; D002685:Chiroptera / Q000097:blood / Q000276:immunology / Q000821:virology*; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000276:immunology; D005260:Female; D016563:Filoviridae / Q000276:immunology*; D018702:Filoviridae Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D006023:Glycoproteins / Q000276:immunology; D057809:HEK293 Cells; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D015995:Prevalence; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D006023:Glycoproteins; D007074:Immunoglobulin G; D014764:Viral Proteins
keywords: Ebola virus; Marburg virus; Zambia; filovirus; fruit bat; specific antibody