title: Clinical validity of the Mattis Dementia Rating Scale in differentiating mild cognitive impairment in Parkinson's disease and normative data.
abstract: OBJECTIVE
  The aim of the present study was to provide normative data and determine the validity of the Czech version of the Mattis Dementia Rating Scale 2 (czDRS-2) in screening for mild cognitive impairment in Parkinson's disease (PD-MCI) based on the Movement Disorder Society (MDS) Level II criteria.
  
  
  METHODS
  For validation purposes, 41 healthy controls (HC), 46 patients with PD-NI (Parkinson's disease, no impairment) and 41 patients with PD-MCI (all groups assessed by the MDS Level II criteria for PD-MCI) were matched according to age and education.
  
  
  RESULTS
  With screening and diagnostic cutoff scores determined at ≤139 points, the czDRS-2 showed a sensitivity of 78% and a specificity of 88% in the detection of PD-MCI versus HC and a sensitivity of 78% and a specificity of 76% in the detection of PD-MCI versus PD-NI. The AUC (95% confidence interval) for the czDRS-2 was 84% (75-93) and 82% (73-91), respectively. We report percentile values for 286 subjects from the Czech population stratified by education level.
  
  
  CONCLUSIONS
  Our results show that the czDRS-2 is a valid instrument at Level I for screening PD-MCI and support its construct validity and diagnostic equivalence in a cross-cultural setting.
authors: Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
authors: Ondrej
authors: O
authors: Bezdicek
authors: Jiri
authors: J
authors: Michalec
authors: Tomas
authors: T
authors: Nikolai
authors: Petra
authors: P
authors: Havránková
authors: Jan
authors: J
authors: Roth
authors: Robert
authors: R
authors: Jech
authors: Evžen
authors: E
authors: Růžička
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D018153:Czech Republic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000523:psychology*; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity