title: Detection of Mayaro virus infections during a dengue outbreak in Mato Grosso, Brazil.
abstract: Arboviruses are common agents of human febrile illness worldwide. In dengue-endemic areas illness due to other arboviruses have been misdiagnosed as dengue based only on clinical-epidemiological data. In this study we investigated the presence of Brazilian arboviruses in sera of 200 patients presenting acute febrile illness, during a dengue outbreak in Sinop, MT, Brazil. The results showed that 38 samples were positive to Dengue virus (DENV) type 1, two samples to DENV type 4, and six to Mayaro virus. These results indicate that arboviruses others than DENV are circulating in Sinop and the surrounding region, which are going undiagnosed. In addition, molecular and evolutionary analyses indicate that two MAYV genotypes are co-circulating in Mato Grosso, Brazil. Thus, a strong surveillance program must be implemented to evaluate and monitor the distribution and the true importance of non-dengue arboviruses in the etiology of acute febrile illnesses.
authors: Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, MT, Brazil.
authors: Carla Julia da Silva Pessoa
authors: CJ
authors: Vieira
authors: Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, MT, Brazil.
authors: David José Ferreira da
authors: DJ
authors: Silva
authors: Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, MT, Brazil.
authors: Eriana Serpa
authors: ES
authors: Barreto
authors: Laboratório Municipal de Análises Clínicas, Sinop, MT, Brazil.
authors: Carlos Eduardo Hassegawa
authors: CE
authors: Siqueira
authors: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.
authors: Tatiana Elias
authors: TE
authors: Colombo
authors: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.
authors: Katia
authors: K
authors: Ozanic
authors: Tufts University, North Grafton, MA, USA.
authors: Diane Johnson
authors: DJ
authors: Schmidt
authors: Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors: Betânia Paiva
authors: BP
authors: Drumond
authors: Universidade Estadual Paulista, Araraquara, SP, Brazil.
authors: Adriano
authors: A
authors: Mondini
authors: Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil.
authors: Maurício Lacerda
authors: ML
authors: Nogueira
authors: Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop, MT, Brazil. Electronic address: robertabronzoni@gmail.com.
authors: Roberta Vieira de Morais
authors: RV
authors: Bronzoni
mesh_terms: D000293:Adolescent; D000328:Adult; D000524:Alphavirus / Q000235:genetics; D018354:Alphavirus Infections / Q000453:epidemiology* / Q000821:virology; D001103:Arboviruses; D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000235:genetics; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D012367:RNA, Viral / Q000032:analysis*; D060888:Real-Time Polymerase Chain Reaction; D055815:Young Adult
chemical_list: D012367:RNA, Viral
keywords: Arboviruses; Febrile illness; RT-PCR