title: Solid-type RCC originating from native kidneys in renal transplant recipients should be monitored cautiously.
abstract: Incidental hemodialysis-related renal cell carcinoma (id-RCC) has been reported to have a good prognosis. However, we have observed rapid progression of id-RCC in some renal transplant patients. Operative indications for id-RCC detected via computed tomography (CT) immediately before renal transplantation (RTx) remain unclear. The purpose of this study was to examine the effects of immunosuppression on the progression of solid-type RCC (s-RCC) and cystic-type RCC (c-RCC). We divided 202 patients with id-RCC into four groups as follows: Group 1, s-RCC with RTx (n = 17); Group 2, c-RCC with RTx (n = 27); Group 3, s-RCC without RTx (n = 53); and Group 4, c-RCC without RTx (n = 105). Five-year cancer specific survival (CSS) rates were significantly worse in Group 1 than Group 3 (79.6% and 100%, respectively, P = 0.012), as were non-recurrence rates (NRRs) (59.2 and 100%, respectively, P < 0.001). In contrast, 5-year CSS rates were similar in Group 2 and Group 4 (100% and 95.7%, respectively, P = 0.295) as were NRR (100% and 98.7%, respectively, P = 0.230). Solid-type RCC should be removed immediately after RTx, and more carefully monitored for recurrence during follow-up.
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Makoto
authors: M
authors: Ryosaka
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Hideki
authors: H
authors: Ishida
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Toshio
authors: T
authors: Takagi
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Tomokazu
authors: T
authors: Shimizu
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Kazunari
authors: K
authors: Tanabe
authors: Department of Urology, Tokyo Women's Medical University, Tokyo, Japan.
authors: Tsunenori
authors: T
authors: Kondo
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D033162:Incidental Findings; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery*; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis / Q000276:immunology* / Q000401:mortality; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000276:immunology; D009392:Nephrectomy; D011182:Postoperative Care / Q000009:adverse effects*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: end-stage renal disease; immunosuppressive therapy; kidney transplantation; renal cell carcinoma