title: Noninvasive method for mapping CVR in moyamoya disease using ASL-MRI.
abstract: OBJECTIVE
  To project a noninvasive method for mapping cerebrovascular reserve (CVR) in moyamoya disease (MMD) using ASL-MRI.
  
  
  METHODS
  16 MMD patients underwent cerebral blood flow (CBF) examinations by standard ASL-MRI, pulse-wave-synchronized ASL-MRI (pulsy ASL-MRI) which tagged the arterial blood coincident with a peak of a pulse wave, and single photon emission computed tomography (SPECT) imagings with iodine-123-N-isopropyl-p-iodoamphetamine in the resting (rest-IMP) and after acetazolamide challenge (ACZ-IMP). Hemispheric 32-sided cerebral blood flow (CBF) values were measured with normalized CBF maps created from standard ASL-MRI (standard-ASL value), pulsy ASL-MRI (pulsy-ASL value), rest-IMP (rest-IMP value), and ACZ-IMP (ACZ-IMP value). CVR based on rest-IMP and ACZ-IMP values (IMP-CVR) was calculated. ASL-CVR was also calculated on the basis of corrected standard-ASL values and pulsy-ASL values, which were adjusted to the ACZ-IMP values and rest-IMP values, respectively, by the least-squares method. We assessed the relationships between rest-IMP values and pulsy-ASL values, ACZ-IMP values and standard-ASL values, and IMP-CVR and ASL-CVR.
  
  
  RESULTS
  Significant relationships were observed between rest-IMP values and pulsy-ASL values (correlation coefficient (r=0.557, p<0.01)), ACZ-IMP values and standard-ASL values (r=0.825, p<0.01), and IMP-CVR and ASL-CVR (r=0.736, p<0.01).
  
  
  CONCLUSIONS
  ASL-MRI is equivalent to SPECT and that it might serve as a noninvasive method for mapping CVR in MMD.
authors: Department of Radiology, National center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan; Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: tnogucci@radiol.med.kyushu-u.ac.jp.
authors: Tomoyuki
authors: T
authors: Noguchi
authors: Department of Neurosugery, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: m996kawa@cc.saga-u.ac.jp.
authors: Masatou
authors: M
authors: Kawashima
authors: Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: nishiham@cc.saga-u.ac.jp.
authors: Masashi
authors: M
authors: Nishihara
authors: Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: bunta1974@yahoo.co.jp.
authors: Yoshiaki
authors: Y
authors: Egashira
authors: Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: azama-ssam-71257@b2.bunbun.ne.jp.
authors: Shinya
authors: S
authors: Azama
authors: Department of Radiology, Faculty of Medicine and Graduate School of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan(1). Electronic address: irie@cc.saga-u.ac.jp.
authors: Hiroyuki
authors: H
authors: Irie
mesh_terms: D000086:Acetazolamide; D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000503:physiopathology*; D064847:Multimodal Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D000086:Acetazolamide
keywords: Arterial spin labeling; Brain Perfusion; MRI; Moyamoya disease; Pulse wave synchronization; SPECT