title: Thymic Origin Neuroendocrine Carcinoma Metastasizing to the Orbit in an Otherwise Asymptomatic Patient.
abstract: A 39-year-old man without a significant medical history developed headaches, OS swelling, and limited left-sided ocular motility. An ultrasound of the left orbit and head MRI revealed a retro-orbital mass. A partial left anterior orbitotomy with partial resection was performed, and histopathologic examination of the resected tumor portion was suggestive of a neuroendocrine carcinoma. A large, anterior mediastinal mass was found on chest imaging, and the patient was diagnosed with a primary thymic neuroendocrine tumor. To the authors' knowledge, this is the first report of an otherwise healthy patient presenting with the mass effects of a thymic neuroendocrine carcinoma metastasis to the orbital tissues before detection of the primary thymic malignancy.
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, U.S.A.
authors: Kyle D
authors: KD
authors: MacLean
authors: Scott C
authors: SC
authors: Cole
authors: Joshua R
authors: JR
authors: Ford
authors: Leah
authors: L
authors: Owen
authors: Nick
authors: N
authors: Mamalis
authors: Bhupendra C K
authors: BC
authors: Patel
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D059248:Chemoradiotherapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D009915:Orbit / Q000601:surgery; D009918:Orbital Neoplasms / Q000378:metabolism / Q000556:secondary* / Q000601:surgery; D049268:Positron-Emission Tomography; D013953:Thymus Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins