title: Prevalence of Regulatory T-Cell Subtypes in Preeclampsia.
abstract: OBJECTIVE
  The prevalence of regulatory T cells (Tregs) is lower in preeclampsia (PE) compared with healthy pregnancy (HP). However, the proportion of recently described Treg subtypes has not been investigated.
  
  
  METHODS
  Peripheral blood samples of 19 PE and 21 HP women in the third trimester were evaluated using flow cytometry for the prevalence of activated T cells and naive, effector, thymic, extrathymic, and exhausted Tregs.
  
  
  RESULTS
  The prevalence of activated T cells and exhausted Tregs was higher in PE than in HP. The prevalence of the functionally most active effector Tregs is decreased, while naive Tregs appear to be unaffected in PE compared with HP. No difference was detected between Tregs according to their origin (thymic or extrathymic).
  
  
  CONCLUSIONS
  The combination of lower effector Treg and higher exhausted Treg prevalence may account for the decrease in the functionality of Tregs in PE.
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors: Gergely
authors: G
authors: Toldi
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors: Zsófia Eszter
authors: ZE
authors: Vásárhelyi
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors: János
authors: J
authors: Rigó
authors: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors: Csaba
authors: C
authors: Orbán
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors: Zita
authors: Z
authors: Tamássy
authors: First Department of Pediatrics, Semmelweis University, Budapest, Hungary.
authors: Anna
authors: A
authors: Bajnok
authors: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors: Tomoko
authors: T
authors: Shima
authors: Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan.
authors: Shigeru
authors: S
authors: Saito
authors: First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary.
authors: Attila
authors: A
authors: Molvarec
mesh_terms: D000328:Adult; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D017493:Leukocyte Common Antigens / Q000276:immunology; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D061026:Programmed Cell Death 1 Receptor / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D017493:Leukocyte Common Antigens
keywords: CD279; Helios; effector Treg; exhausted Treg; naive Treg; preeclampsia