title: Relationship between the FAS gene A-670G polymorphism and Alzheimer's disease: a meta-analysis.
abstract: OBJECTIVE
  The pathogenetic mechanism of Alzheimer's disease (AD) is still unknown; however, gene polymorphism may play a critical role in the pathogenesis of AD. The aim of this meta-analysis was to evaluate the association between FAS gene A-670G polymorphism and AD.
  
  
  METHODS
  We searched all related subjects in PubMed, Embase, Cochrane Library, SinoMed, and the China Knowledge Resource Integrated Database and identified seven studies reporting a relationship between the A-670G polymorphism in the FAS gene and AD.
  
  
  RESULTS
  A total of 1512 cases and 1707 controls were included in the seven studies. The meta-analyses results suggested no significant association between the A-670G polymorphism and AD in any genetic models. When a subgroup analysis was conducted by ethnicity, the A-670G polymorphism was also not relevant to AD. However, when stratified by age, the GG genotype increased the risk of early-onset AD. We also found that the A-670G polymorphism was related to patients with AD who carried the apolipoprotein-E ε4 allele in three genetic models.
  
  
  CONCLUSIONS
  To sum up, our data suggested that the FAS gene A-670G polymorphism may not be associated with AD. When a subgroup analysis was conducted by ethnicity, the A-670G polymorphism was also not related with AD in Asian and Caucasian population. However, the FAS-670 GG genotype may increase the risk of AD in the younger population (age, ≤65 years). Furthermore, we found that the A-670G polymorphism was related to patients with AD who carried the APOE4 allele in dominant, allele and homozygous models.
authors: Nanjing Medical University, Nanjing, 210029, China.
authors: Jinlong
authors: J
authors: Zhu
authors: Department of Neurology, The Jintan Hospital Affiliated to Jiangsu University, Changzhou, 213200, China.
authors: Jianhua
authors: J
authors: Su
authors: Department of Orthopaedic Trauma, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, China. lrp216@sina.com.|Central Laboratory, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, China. lrp216@sina.com.
authors: Ruiping
authors: R
authors: Liu
authors: Department of Cerebral Surgery, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, China. Jingsong_yang@126.com.
authors: Jinsong
authors: J
authors: Yang
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005838:Genotype; D006720:Homozygote; D006801:Humans; D011110:Polymorphism, Genetic; D012306:Risk; D019014:fas Receptor / Q000235:genetics*
chemical_list: C491901:FAS protein, human; D019014:fas Receptor
keywords: A-670G; Alzheimer’s disease; FAS; Meta-analysis; Polymorphism; SNP