title: Distribution of the CCR5-delta32 deletion in Southwest Germany.
abstract: A 32 base pair deletion in the c-c chemokine receptor gene 5 (CCR5) leads to an inactive protein. Carriers of this deletion must have had a selective advantage because the allelic frequency of the CCR5-delat32 mutation is much higher than expected. Furthermore, there is a decline from North to South Europe. For Germany there are just very few cross-sectional surveys available. Here we investigated a large number of healthy blood donors from Northern Baden-Wuerttemberg. We observed an allelic frequency of 9.21 % of the CCR5-delta32 deletion. The distribution did not follow the Hardy-Weinberg equilibrium suggesting that homozygous carriers of the deletion were overrepresented in this random sample.
authors: Cellex GmbH, Dresden, Germany.|Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University.|German Red Cross Blood Service Baden-Württemberg - Hessen, Germany.
authors: Gero
authors: G
authors: Hütter
authors: Cellex GmbH, Dresden, Germany.|Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University.|German Red Cross Blood Service Baden-Württemberg - Hessen, Germany.
authors: Christian
authors: C
authors: Blüthgen
authors: Cellex GmbH, Dresden, Germany.|Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University.|German Red Cross Blood Service Baden-Württemberg - Hessen, Germany.
authors: Susanne
authors: S
authors: Elvers-Hornung
authors: Cellex GmbH, Dresden, Germany.|Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University.|German Red Cross Blood Service Baden-Württemberg - Hessen, Germany.
authors: Harald
authors: H
authors: Klüter
authors: Cellex GmbH, Dresden, Germany.|Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University.|German Red Cross Blood Service Baden-Württemberg - Hessen, Germany.
authors: Peter
authors: P
authors: Bugert
mesh_terms: D001782:Blood Donors / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D005787:Gene Frequency; D005858:Germany / Q000453:epidemiology; D006801:Humans; D017720:Molecular Epidemiology; D009154:Mutation / Q000235:genetics; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5