title: Arterial and portal venous liver perfusion using selective spin labelling MRI.
abstract: OBJECTIVE
  To investigate the feasibility of selective arterial and portal venous liver perfusion imaging with spin labelling (SL) MRI, allowing separate labelling of each blood supply.
  
  
  METHODS
  The portal venous perfusion was assessed with a pulsed EPISTAR technique and the arterial perfusion with a pseudo-continuous sequence. To explore precision and reproducibility, portal venous and arterial perfusion were separately quantified in 12 healthy volunteers pre- and postprandially (before and after meal intake). In a subgroup of 6 volunteers, the accuracy of the absolute portal perfusion and its relative postprandial change were compared with MRI flow measurements of the portal vein.
  
  
  RESULTS
  The portal venous perfusion significantly increased from 63 ± 22 ml/100g/min preprandially to 132 ± 42 ml/100g/min postprandially. The arterial perfusion was lower with 35 ± 22 preprandially and 22 ± 30 ml/100g/min postprandially. The pre- and postprandial portal perfusion using SL correlated well with flow-based perfusion (r(2) = 0.71). Moreover, postprandial perfusion change correlated well between SL- and flow-based quantification (r(2) = 0.77). The SL results are in range with literature values.
  
  
  CONCLUSIONS
  Selective spin labelling MRI of the portal venous and arterial blood supply successfully quantified liver perfusion. This non-invasive technique provides specific arterial and portal venous perfusion imaging and could benefit clinical settings where contrast agents are contraindicated.
  
  
  CONCLUSIONS
  • Perfusion imaging of the liver by Spin Labelling MRI is feasible • Selective Spin Labelling MRI assessed portal venous and arterial liver perfusion separately • Spin Labelling based portal venous liver perfusion showed significant postprandial increase • Spin Labelling based portal perfusion correlated well with phase-contrast based portal perfusion • This non-invasive technique could benefit settings where contrast agents are contraindicated.
authors: Department of Radiology, University Medical Center Utrecht, HP E.01.132, Postbus 85500, 3508 GA, Utrecht, The Netherlands, h.schalkx@gmail.com.
authors: Hanke J
authors: HJ
authors: Schalkx
authors: Esben T
authors: ET
authors: Petersen
authors: Nicky H G M
authors: NH
authors: Peters
authors: Wouter B
authors: WB
authors: Veldhuis
authors: Maarten S
authors: MS
authors: van Leeuwen
authors: Josien P W
authors: JP
authors: Pluim
authors: Maurice A A J
authors: MA
authors: van den Bosch
authors: Marijn
authors: M
authors: van Stralen
mesh_terms: D000328:Adult; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000502:physiology*; D011169:Portal Vein / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D012016:Reference Values; D015203:Reproducibility of Results; D013113:Spin Labels
chemical_list: D013113:Spin Labels