title: Validation of the Pancreas Donor Risk Index for use in a UK population.
abstract: Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P = 0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.|Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
authors: Shruti
authors: S
authors: Mittal
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Fang Jann
authors: FJ
authors: Lee
authors: NHS Blood and Transplant, Bristol, UK.
authors: Lisa
authors: L
authors: Bradbury
authors: NHS Blood and Transplant, Bristol, UK.
authors: David
authors: D
authors: Collett
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Srikanth
authors: S
authors: Reddy
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Sanjay
authors: S
authors: Sinha
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Edward
authors: E
authors: Sharples
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Rutger J
authors: RJ
authors: Ploeg
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.|Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.|NIHR Biomedical Research Centre, Oxford, UK.
authors: Peter J
authors: PJ
authors: Friend
authors: Oxford Transplant Centre, Oxford University Hospital NHS Trust, Oxford, UK.
authors: Anil
authors: A
authors: Vaidya
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000379:methods* / Q000592:standards; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000502:physiology; D016035:Pancreas Transplantation / Q000379:methods* / Q000592:standards; D016016:Proportional Hazards Models; D012042:Registries; D012307:Risk Factors; D012720:Severity of Illness Index; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000379:methods / Q000592:standards; D016896:Treatment Outcome; D006113:United Kingdom
keywords: graft survival; pancreas transplant; predictor; risk