title: Cut-off values of waist circumference to predict metabolic syndrome in obese adolescents.
abstract: BACKGROUND
  Metabolic syndrome (MetS) is a constellation of metabolic alteration related to abdominal obesity, inflammation and insulin resistance, which increase cardiovascular disease and mortality. The aims of the present study were to identify the prevalence of comorbidities and altered parameters in obese adolescents with and without MetS, and determine cut-off points of waist circumference to predict MetS.
  
  
  METHODS
  195 obese adolescents were recruited and divided according to MetS diagnosis based on IDF criteria. Blood analyses of glucose, lipids, liver enzymes, adiponectin and leptin were measured. Insulin resistance was assessed by HOMA-IR, QUICKI and HOMA-AD. Visceral, subcutaneous and hepatic fat were ultrasonography obtained. Body composition was estimated by BOD POD system.
  
  
  RESULTS
  We observed a prevalence of 25% of MetS (n=50). The MetS group presented significant higher body mass, BMI, body fat (kg), free-fat mass (kg), waist circumference, visceral fat, glucose, insulin, insulin resistance, total-cholesterol, LDL-c, VLDL-c, triglycerides, liver enzymes, non-alcoholic fatty liver disease (NAFLD) and blood pressure. Significant lower QUICKI and adiponectin in MetS group were noted. MetS girls presented significant higher leptin/adiponectin ratio compared to Non-MetS girls. Cut-off points of 111.5 cm for boys and 104.6 cm for girls of waist circumference were suggested to predict metabolic syndrome. Moreover, waist circumference was positive correlated with visceral fat and the number of metabolic syndrome parameters.
  
  
  CONCLUSIONS
  MetS group presented significant higher metabolic alterations and inflammation compared to Non-MetS group. Waist circumference is considered an anthropometric measure predictor of metabolic syndrome in obese adolescents, being useful in clinical practice.
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. deborahmasquio@yahoo.com.br.
authors: Deborah Cristina Landi
authors: DC
authors: Masquio
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. aline.depiano@gmail.com.
authors: Aline de Piano
authors: Ade P
authors: Ganen
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. raquelmunhoz@hotmail.com.
authors: Raquel Munhoz da Silveira
authors: RM
authors: Campos
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. prisan27@yahoo.com.br.
authors: Priscila de Lima
authors: Pde L
authors: Sanches
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. flavia@cepebr.org.
authors: Flávia Campos
authors: FC
authors: Corgosinho
authors: Post Graduate Program of Interdisciplinary Health Science, Universidade Federal de São Paulo (UNIFESP), Santos-SP.. danielle.caranti@unifesp.br.
authors: Danielle
authors: D
authors: Caranti
authors: Weight Science, São Paulo-SP.. lionto@uol.com.br.
authors: Lian
authors: L
authors: Tock
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP.. tmello@demello.net.
authors: Marco Túlio
authors: MT
authors: de Mello
authors: Department of Psychobiology Universidade Federal de São Paulo (UNIFESP), São Paulo-SP. Brasil.. s.tufik@unifesp.br.
authors: Sergio
authors: S
authors: Tufik
authors: Post-Graduate Program of Nutrition, Universidade Federal de São Paulo (UNIFESP), São Paulo-SP. Post Graduate Program of Interdisciplinary Health Science, Universidade Federal de São Paulo (UNIFESP), Santos-SP.. ana.damaso@unifesp.br.
authors: Ana R
authors: AR
authors: Dâmaso
mesh_terms: D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis*; D009765:Obesity / Q000150:complications*; D011237:Predictive Value of Tests; D012016:Reference Values; D055105:Waist Circumference; D055815:Young Adult