title: The 2011-2014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States.
abstract: BACKGROUND
  Eosinophilic oesophagitis (EoE) is primarily diagnosed by clinicians. There are less than a handful of epidemiological studies in EoE that have included elderly patients (>65 years).
  
  
  OBJECTIVE
  To determine the prevalence of elderly subjects among EoE patients and compare their clinical presentation, associated conditions and treatment modalities with adult and paediatric EoE patients.
  
  
  METHODS
  A large nationwide database (Explorys) between January 2011 and January 2014 was used. The term 'Eosinophilic Oesophagitis' was used in the Explorys search tool. The patient population was divided into three groups, Paediatric (<18 years), Adult (18-65 years) and Elderly (>65 years).
  
  
  RESULTS
  We identified 4840 patients coded as EoE. The total estimated prevalence was 50.6 cases per 100 000 patients (0.05%). A total of 360 cases (7.44%) were elderly patients with an estimated prevalence rate of 18.6 cases per 100 000. Across all age groups, the majority of EoE patients were Caucasians and males. A significantly greater proportion of older patients had concomitant GERD. Dysphagia was the most common symptom among elderly EoE patients as compared with the paediatric EoE patients (P < 0.001). The proportion of elderly EoE patients with food allergies or asthma was significantly lower as compared with paediatric and adult EoE patients (P < 0.001). Oesophageal dilation and/or proton pump inhibitor treatment were the most commonly used therapeutic modalities in elderly EoE patients.
  
  
  CONCLUSIONS
  Eosinophilic oesophagitis is uncommon in elderly subjects and the clinical presentation is markedly different as compared with adults or the paediatric population.
authors: Division of Gastroenterology and Hepatology, The Esophageal and Swallowing Center, Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA.
authors: C
authors: C
authors: Maradey-Romero
authors: R
authors: R
authors: Prakash
authors: S
authors: S
authors: Lewis
authors: A
authors: A
authors: Perzynski
authors: R
authors: R
authors: Fass
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001249:Asthma / Q000453:epidemiology; D002648:Child; D016208:Databases, Factual; D003680:Deglutition Disorders / Q000453:epidemiology* / Q000209:etiology; D004106:Dilatation / Q000379:methods; D057765:Eosinophilic Esophagitis / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D054328:Proton Pump Inhibitors