title: Depression and quality of life in relation to decreased glomerular filtration rate among adults with hypertension in rural northeast China.
abstract: OBJECTIVE
  We aim to investigate the extent to which depression and quality of life might be associated with decreased glomerular filtration rate (GFR) in a large hypertensive population in rural Northeast China.
  
  
  METHODS
  A total of 5566 hypertensive participants aged 35 years and older were screened with a stratified cluster multistage sampling scheme in rural areas of Liaoning Province during 2012-2013. Decreased GFR was defined as estimated GFR <60 ml/min/1.73 m2.
  
  
  RESULTS
  The overall prevalence of decreased GFR was 3.2%. In the multivariable regression model, participants with moderate or greater depression had a greater risk for having a decreased GFR (OR: 1.739, 95%CI: 1.004 to 3.014) after full adjustment. Every -point increase of all the domains in WHOQOL-BREF, except for physical and environment domains, was significantly related to a lower risk for decreased GFR adjusting for age, gender and race. However, after fully adjustment, only social relations remained significant (OR: 0.899, 95%CI: 0.820 to 0.985). Increasing in total scores of WHOQOL-BREF was a protective factor against decreased GFR after fully adjustment.
  
  
  CONCLUSIONS
  We found that moderate or greater depression and lower quality of life were associated with higher risks for developing decreased GFR.
authors: Xiaofan
authors: X
authors: Guo
authors: Zhao
authors: Z
authors: Li
authors: Shasha
authors: S
authors: Yu
authors: Hongmei
authors: H
authors: Yang
authors: Liang
authors: L
authors: Guo
authors: Liqiang
authors: L
authors: Zheng
authors: Luoning
authors: L
authors: Zhu
authors: Yonghong
authors: Y
authors: Zhang
authors: Yingxian
authors: Y
authors: Sun
mesh_terms: D000368:Aged; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology; D011897:Random Allocation; D012424:Rural Population; D011795:Surveys and Questionnaires