title: Prognostic significance of anti-aminoacyl-tRNA synthetase antibodies in polymyositis/dermatomyositis-associated interstitial lung disease: a retrospective case control study.
abstract: BACKGROUND
  In polymyositis/dermatomyositis (PM/DM), anti-aminoacyl-tRNA synthetase (ARS) antibodies are closely associated with interstitial lung disease (ILD), a frequent pulmonary complication. However, the clinical significance of anti-ARS antibodies is not well established.
  
  
  OBJECTIVE
  We aimed to evaluate the clinical significance of anti-ARS antibodies in PM/DM-ILD patients.
  
  
  METHODS
  Forty-eight consecutive PM/DM-ILD patients were studied retrospectively. Anti-ARS antibodies were screened by ELISA and confirmed by RNA immunoprecipitation test. Medical records, high-resolution computed tomography images, and surgical lung biopsy specimens were compared between ARS-positive (ARS group) and ARS-negative patients (non-ARS group).
  
  
  RESULTS
  Anti-ARS antibodies were detected in 23 of 48 patients (48%). Radiologically, nonspecific interstitial pneumonia (NSIP) pattern was observed more frequently in the ARS group than in the non-ARS group (73.9% vs. 40%, P = 0.02). Pathologically, NSIP was the most frequent in both groups. Ten-year survival rate was also significantly higher in the ARS group than in the non-ARS group (91.6% vs. 58.7%, P = 0.02). Univariate Cox hazards analysis revealed that the presence of anti-ARS antibodies was associated with better prognosis (HR = 0.34, 95% CI 0.08-0.80; P = 0.01).
  
  
  CONCLUSIONS
  The presence of anti-ARS antibodies is a possible prognostic marker in patients with PM/DM-ILD.
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Hironao
authors: H
authors: Hozumi
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Noriyuki
authors: N
authors: Enomoto
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Masato
authors: M
authors: Kono
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Tomoyuki
authors: T
authors: Fujisawa
authors: Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Naoki
authors: N
authors: Inui
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Yutaro
authors: Y
authors: Nakamura
authors: Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors: Hiromitsu
authors: H
authors: Sumikawa
authors: Department of Radiology, Kinki Central Hospital of Mutual Aid Association of Public School Teachers, Itami-city, Hyogo, Japan.
authors: Takeshi
authors: T
authors: Johkoh
authors: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Ran
authors: R
authors: Nakashima
authors: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Yoshitaka
authors: Y
authors: Imura
authors: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Tsuneyo
authors: T
authors: Mimori
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Takafumi
authors: T
authors: Suda
mesh_terms: D000328:Adult; D000368:Aged; D000604:Amino Acyl-tRNA Synthetases / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D003882:Dermatomyositis / Q000150:complications / Q000401:mortality / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D047468:Immunoprecipitation; D053208:Kaplan-Meier Estimate; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D017285:Polymyositis / Q000150:complications / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D000604:Amino Acyl-tRNA Synthetases