title: Germline mutations predisposing to non-small cell lung cancer.
abstract: Lung cancer in multiple first degree relatives had previously been attributed to smoking and to inherited enzymes associated with increased activation of carcinogens in smoke. There was not clear agreement on the significance of the testing methods for lung cancer susceptibility. More recent studies have identified germline mutations associated with lung cancer even in the absence of smoking and other mutations with plausible explanations for their association with lung cancer caused by smoking. At this time, the clinical significance of the various germline mutations for screening and the implications for therapy are not certain. This review summarizes the currently identified germline mutations associated with lung cancer, but this growing area of research will very likely identify further significant mutations as well.
authors: Department of Internal Medicine, University of Iowa College of Medicine, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA, 52242, USA, gerald-clamon@uiowa.edu.
authors: Gerald H
authors: GH
authors: Clamon
authors: Aaron D
authors: AD
authors: Bossler
authors: Taher
authors: T
authors: Abu Hejleh
authors: Muhammad
authors: M
authors: Furqan
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors