title: Diacerein improves left ventricular remodeling and cardiac function by reducing the inflammatory response after myocardial infarction.
abstract: BACKGROUND
  The inflammatory response has been implicated in the pathogenesis of left ventricular (LV) remodeling after myocardial infarction (MI). An anthraquinone compound with anti-inflammatory properties, diacerein inhibits the synthesis and activity of pro-inflammatory cytokines, such as tumor necrosis factor and interleukins 1 and 6. The purpose of this study was to investigate the effects of diacerein on ventricular remodeling in vivo.
  
  
  RESULTS
  Ligation of the left anterior descending artery was used to induce MI in an experimental rat model. Rats were divided into two groups: a control group that received saline solution (n = 16) and a group that received diacerein (80 mg/kg) daily (n = 10). After 4 weeks, the LV volume, cellular signaling, caspase 3 activity, and nuclear factor kappa B (NF-κB) transcription were compared between the two groups. After 4 weeks, end-diastolic and end-systolic LV volumes were reduced in the treatment group compared to the control group (p < .01 and p < .01, respectively). Compared to control rats, diacerein-treated rats exhibited less fibrosis in the LV (14.65%± 7.27% vs. 22.57%± 8.94%; p < .01), lower levels of caspase-3 activity, and lower levels of NF-κB p65 transcription.
  
  
  CONCLUSIONS
  Treatment with diacerein once a day for 4 weeks after MI improved ventricular remodeling by promoting lower end-systolic and end-diastolic LV volumes. Diacerein also reduced fibrosis in the LV. These effects might be associated with partial blockage of the NF-κB pathway.
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Anali Galluce
authors: AG
authors: Torina
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Karla
authors: K
authors: Reichert
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Fany
authors: F
authors: Lima
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Karlos Alexandre
authors: KA
authors: de Souza Vilarinho
authors: Department of Surgery, Discipline of Cardiac Surgery, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Pedro Paulo Martins
authors: PP
authors: de Oliveira
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Helison Rafael Pereira
authors: HR
authors: do Carmo
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Daniela Diógenes
authors: DD
authors: de Carvalho
authors: Department of Internal Medicine, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Mário José Abdalla
authors: MJ
authors: Saad
authors: Department of Internal Medicine, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Andrei Carvalho
authors: AC
authors: Sposito
authors: Laboratory of Myocardial Ischemia/Reperfusion, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil; Department of Surgery, Discipline of Cardiac Surgery, Faculty of Medical Science, State University of Campinas-UNICAMP, Campinas, SP, Brazil.
authors: Orlando
authors: O
authors: Petrucci
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000008:administration & dosage* / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D053148:Caspase 3 / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D051996:Transcription Factor RelA / Q000235:genetics; D016277:Ventricular Function, Left / Q000187:drug effects*; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D000880:Anthraquinones; D000893:Anti-Inflammatory Agents; C498145:Rela protein, rat; D051996:Transcription Factor RelA; C025292:diacerein; C505410:Casp3 protein, rat; D053148:Caspase 3