title: Chemical components from the leaves of Ardisia insularis and their cytotoxic activity.
abstract: One new oleanane triterpene glycoside, ardinsuloside (1), and twelve known compounds, demethoxybergenin (2), norbergenin (3), bergenin (4), 4-O-galloylbergenin (5), quercitrin (6), myricitrin (7), myricetin 3-O-(3''-O-galloyl)-α-L-rhamnopyranoside (8), desmanthine-2 (9), epicatechin 3-O-galloyl ester (10), 3'-methoxyepicatechin 3-O-galloyl ester (11), gallic acid (12), and methyl galloate (13) were isolated from the leaves of Ardisia insularis. Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on three cancer cell lines namely A-549 (human lung cancer), HT-29 (Human colon adenocarcinoma), and OVCAR (human ovarian carcinoma). The results revealed that compound 1 inhibited A-549, HT-29, and OVCAR cell lines with IC50 values of 8.5 ± 1.2, 16.4 ± 3.1, and 13.6 ± 2.4 μM, respectively. The remaining compound showed weak cytotoxic activity. This result indicated that compound 1 could be useful in the treatment of cancer disease.
authors: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Nguyen Thi Hong
authors: NT
authors: Van
authors: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.|Industrial University of Ho Chi Minh city, Quang Tam, Thanh Hoa, Vietnam.
authors: Trinh Anh
authors: TA
authors: Vien
authors: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Phan
authors: P
authors: Van Kiem
authors: Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Chau
authors: C
authors: Van Minh
authors: Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 406-840, Korea.|Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Nguyen Xuan
authors: NX
authors: Nhiem
authors: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Pham Quoc
authors: PQ
authors: Long
authors: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
authors: Luu Tuan
authors: LT
authors: Anh
authors: Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 406-840, Korea.
authors: Nanyoung
authors: N
authors: Kim
authors: Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 406-840, Korea.
authors: SeonJu
authors: S
authors: Park
authors: Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, 406-840, Korea. kimsh11@yonsei.ac.kr.
authors: Seung Hyun
authors: SH
authors: Kim
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D031644:Ardisia / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Ardinsuloside; Ardisia insularis; Cytotoxic activity; Myrsinaceae