title: [Genetic and environmental factors of asthma and allergy: Results of the EGEA study].
abstract: METHODS
  The EGEA study (epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), which combines a case-control and a family-based study of asthma case (n=2120 subjects) with three surveys over 20 years, aims to identify environmental and genetic factors associated with asthma and asthma-related phenotypes. We summarize the results of the phenotypic characterization and the investigation of environmental and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles).
  
  
  RESULTS
  Both epidemiological and genetic results confirm the heterogeneity of asthma. These results strengthen the role of the age of disease onset, the allergic status and the level of disease activity in the identification of the different phenotypes of asthma. The deleterious role of active smoking, exposure to air pollution, occupational asthmogenic agents and cleaning products on the prevalence and/or activity of asthma has been confirmed. Accounting for gene-environment interactions allowed the identification of new genetic factors underlying asthma and asthma-related traits and better understanding of their mode of action.
  
  
  CONCLUSIONS
  The EGEA study is contributing to the advances in respiratory research at the international level. The new phenotypic, environmental and biological data available in EGEA study will help characterizing the long-term evolution of asthma and the factors associated to this evolution.
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.
authors: E
authors: E
authors: Bouzigon
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: R
authors: R
authors: Nadif
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: N
authors: N
authors: Le Moual
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France.
authors: M-H
authors: MH
authors: Dizier
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France.
authors: H
authors: H
authors: Aschard
authors: Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France.
authors: A
authors: A
authors: Boudier
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; CHU Arnaud-de-Villeneuve, 34000 Montpellier, France.
authors: J
authors: J
authors: Bousquet
authors: Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Pôle de pharmacie, CHU de Grenoble, 38000 Grenoble, France; Inserm, U1055, 38000 Grenoble, France.
authors: S
authors: S
authors: Chanoine
authors: AP-HP, université Paris Descartes, Sorbonne Paris-Cité, 75005 Paris, France.
authors: C
authors: C
authors: Donnay
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: O
authors: O
authors: Dumas
authors: CHU, 69000 Lyon, France.
authors: F
authors: F
authors: Gormand
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; CREAL, centre for research in environmental epidemiology, Barcelone, Espagne.
authors: B
authors: B
authors: Jacquemin
authors: Centre de l'asthme et des allergies, hôpital Trousseau, AP-HP, UMPC Paris 6, 75012 Paris, France.
authors: J
authors: J
authors: Just
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France.
authors: P
authors: P
authors: Margaritte-Jeannin
authors: Université Lille Nord de France, 59000 Lille, France; CHU, 59000 Lille, France.
authors: R
authors: R
authors: Matran
authors: Clinique universitaire de pneumologie, pôle de cancérologie, médecine aiguë et communautaire, CHU de Grenoble, 38000 Grenoble, France; Inserm, U1055, 38000 Grenoble, France; Université Grenoble Alpes, 38000 Grenoble, France.
authors: C
authors: C
authors: Pison
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France; PRP-HOM, SRBE, LEPID, institut de radioprotection et de sûreté nucléaire (IRSN), 92260 Fontenay-aux-Roses, France.
authors: E
authors: E
authors: Rage
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: M
authors: M
authors: Rava
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France.
authors: C
authors: C
authors: Sarnowski
authors: Division of environmental epidemiology, institute for risk assessment sciences (IRAS), Utrecht, Pays-Bas.
authors: L A M
authors: LA
authors: Smit
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: S
authors: S
authors: Temam
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: R
authors: R
authors: Varraso
authors: Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France.
authors: L
authors: L
authors: Vignoud
authors: McGill university and génome Québec innovation centre, Montréal, Canada.
authors: M
authors: M
authors: Lathrop
authors: Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France.
authors: I
authors: I
authors: Pin
authors: Inserm, UMR946, 75010 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, institut universitaire d'hématologie, 75007 Paris, France.
authors: F
authors: F
authors: Demenais
authors: Inserm, centre for research in epidemiology and population health (CESP), U1018, respiratory and environmental epidemiology team, 94807 Villejuif, France; Université Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors: F
authors: F
authors: Kauffmann
authors: Université Grenoble Alpes, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; Inserm, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France; CHU de Grenoble, IAB, team of environmental epidemiology applied to reproduction and respiratory health, 38000 Grenoble, France.
authors: V
authors: V
authors: Siroux
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000397:Air Pollution / Q000009:adverse effects; D001249:Asthma / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D016535:Bronchial Hyperreactivity / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D004781:Environmental Exposure; D005192:Family Health; D005602:France; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006306:Health Surveys; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D014028:Tobacco Smoke Pollution
keywords: Allergie; Allergy; Asthma; Asthme; Environment; Environnement; Genetics; Génétique; Heterogeneity; Hétérogénéité