title: Rate of early onset Alzheimer's disease: a systematic review and meta-analysis.
abstract: It is generally accepted that the population rate of early onset Alzheimer's disease (EOAD) in Alzheimer's disease (AD) is 1-2%. However, the true population based rate of EOAD has never been verified by a systematic review and meta-analysis. We used electronic searches of Cochrane Library, Embase, Medline and PubMed databases to identify published related studies. The systematic review and meta-analysis was then to be conducted to calculate a pooled rate of EOAD and make comparisons between studies and geographic distribution. A total of 13 papers were included in our systematic review and meta-analysis. The rate of EOAD, 5.5% [95% confidence interval (CI): 0.039-0.079, P<0.001], was generated after pooled analysis of all studies in random effect model. The pooled analysis of the rate in developed country was 5.9% (95% CI: 0.040-0.085, P<0.001). The pooled analysis of the rate in developing countries was 4.4% (95% CI: 0.028-0.066, P<0.001). Our study showed that the rate of EOAD in AD is 5.5%, not 1-2% as usually demonstrated. And our results indicated that the rate in developed countries was relative higher than in developing countries. Further trials with larger samples across more countries and more careful designed of experiments are required to confirm whether our findings are truly significant.
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Xi-Chen
authors: XC
authors: Zhu
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Lan
authors: L
authors: Tan
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Hui-Fu
authors: HF
authors: Wang
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Teng
authors: T
authors: Jiang
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Lei
authors: L
authors: Cao
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Chong
authors: C
authors: Wang
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Jun
authors: J
authors: Wang
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Chen-Chen
authors: CC
authors: Tan
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Xiang-Fei
authors: XF
authors: Meng
authors: 1 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao 266071, China ; 2 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 3 Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA.
authors: Jin-Tai
authors: JT
authors: Yu
keywords: Alzheimer’s disease (AD); Early onset Alzheimer’s disease (EOAD); meta-analysis; rate