title: [The effects of DNA methylation on the homeostasis in vascular diseases].
abstract: Homeostasis is fundamental to maintain normal physiological functions in our body. Internal and external physical, chemical and biologial changes can cause dysregulation of vascular homeostasis, which is closely associated with the homeostasis of oxygen supply, blood transportation and lipid metabolism. Subsequent epigenetic modifications are able to lead to abnormal structures and function of vessels. DNA methylation has been shown to play a vital role in the development of vascular diseases. In addition, 5-hydroxymethylcytosine (5hmC) and N(6)-methyladenine (m(6)A), as new epigenetic modifications, provide additional clues for vascular diseases. In this review, we summarize the effects of DNA methylation on the homeostasis dysregulation in the vascular diseases.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: Xiao-Ying
authors: XY
authors: Chen
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: Hua-Dan
authors: HD
authors: Ye
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: Qing-Xiao
authors: QX
authors: Hong
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: An-Nan
authors: AN
authors: Zhou
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: Lin-Lin
authors: LL
authors: Tang
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China.
authors: Shi-Wei
authors: SW
authors: Duan
mesh_terms: D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006706:Homeostasis; D006801:Humans; D014652:Vascular Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology