title: First report of a Klebsiella pneumoniae ST466 strain causing neonatal sepsis harbouring the blaCTX-M-15 gene in Rabat, Morocco.
abstract: Klebsiella pneumoniae is one of the Gram-negative bacilli most commonly found in urine of pregnant women and causing neonatal sepsis. The aim of this study was to analyse in terms of epidemiology and antimicrobial resistance of 23 K. pneumoniae isolates collected from vaginal swabs or urine of pregnant women, from pharyngeal and ear swabs of apparently healthy newborns and from peripheral cultures and hemocultures of newborns with suspected invasive neonatal infection in Rabat, Morocco. The prevalence of K. pneumoniae was 0.6 and 0.9% among pregnant women and neonates, respectively. These strains showed lower antimicrobial resistance levels regarding the developed countries. Thus, only one strain from a neonate presented an ESBL. This is the first report of a K. pneumoniae strain causing neonatal sepsis harbouring the blaCTX-M-15 gene in an IncFII plasmid and belonging to ST466 in this area.
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain.
authors: Victoria
authors: V
authors: Ballén
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain.
authors: Emma
authors: E
authors: Sáez
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain.
authors: Rachid
authors: R
authors: Benmessaoud
authors: Équipe de Recherche en Santé et Nutrition du Couplé Mère Enfant, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Morocco.
authors: Tligui
authors: T
authors: Houssain
authors: Équipe de Recherche de Périnatologie, Université Mohammed V Souissi, Rabat, Morocco.
authors: Hassan
authors: H
authors: Alami
authors: Équipe de Recherche en Santé et Nutrition du Couplé Mère Enfant, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Morocco.
authors: Amina
authors: A
authors: Barkat
authors: Équipe de Recherche en Santé et Nutrition du Couplé Mère Enfant, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Morocco.
authors: Meryem
authors: M
authors: Kabiri
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain.
authors: Cinta
authors: C
authors: Moraleda
authors: Équipe de Recherche de Périnatologie, Université Mohammed V Souissi, Rabat, Morocco.
authors: Rachid
authors: R
authors: Bezad
authors: School of Medicine, University of Barcelona, 08036 Barcelona, Spain.
authors: Jordi
authors: J
authors: Vila
authors: School of Medicine, University of Barcelona, 08036 Barcelona, Spain.
authors: Jordi
authors: J
authors: Bosch
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain.
authors: Quique
authors: Q
authors: Bassat
authors: Barcelona Centre for International Health Research (CRESIB, Hospital Clinic-University of Barcelona), 08036 Barcelona, Spain sara.soto@cresib.cat.
authors: Sara M
authors: SM
authors: Soto
mesh_terms: D001769:Blood / Q000382:microbiology; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial; D004423:Ear / Q000382:microbiology; D005260:Female; D022761:Gene Transfer, Horizontal; D006801:Humans; D007231:Infant, Newborn; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D009018:Morocco / Q000453:epidemiology; D058885:Multilocus Sequence Typing; D010957:Plasmids / Q000032:analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D015995:Prevalence; D018805:Sepsis / Q000382:microbiology*; D014556:Urine / Q000382:microbiology; D014621:Vagina / Q000382:microbiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases
keywords: ESBL; plasmid; sepsis