title: Evaluation of emphysema using three-dimensional computed tomography: association with postoperative complications in lung cancer patients.
abstract: Three-dimensional computed tomography (3D-CT) enables in vivo volumetry of total lung volume (TLV) and emphysematous low-attenuation volume (LAV) in patients with chronic obstructive pulmonary disease (COPD). We retrospectively investigated the correlation between preoperative 3D-CT volumetry and postoperative complications in lung cancer patients. We searched our institution's surgical records from December 2006 to December 2009 and selected patients who had undergone pulmonary lobectomy for primary lung cancer. From 3D-CT data, TLV and LAV <-950 HU of thresholds were retrospectively measured. The LAV% was calculated as follows: LAV% = LAV/TLV*100. The associations between the seven independent variables (LAV%, age, gender, body mass index, smoking history, forced expiratory volume in 1 second as percent forced vital capacity [FEV1%], and resected lobe) and the two outcomes (postoperative complications and prolonged postoperative stay [PPS]) were compared using logistic regression analysis. A total of 309 patients (222 males, 87 females; mean age, 67 years; range, 40-87 years) were evaluated. On multivariate analysis, age and LAV% were significantly correlated with postoperative complications (p = 0.006 and p = 0.006, respectively), and LAV% was significantly correlated with PPS (p = 0.031). LAV% measured using 3D-CT is more sensitive for predicting complications after lobectomy for lung cancer than FEV1%.
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan ; Department of Radiology, Toyota Memorial Hospital, Toyota, Japan.
authors: Kenichi
authors: K
authors: Kawakami
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Shingo
authors: S
authors: Iwano
authors: Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Naozumi
authors: N
authors: Hashimoto
authors: Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Yoshinori
authors: Y
authors: Hasegawa
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors: Shinji
authors: S
authors: Naganawa
keywords: Chronic obstructive pulmonary disease; Computed tomography; Lung cancer; Postoperative complication; Thoracic surgery