title: Dactylomelane diterpenes from the sea hare Aplysia depilans.
abstract: A chemical investigation of the organic extract of the sea hare Aplysia depilans, collected off Skyros Island, Greece, yielded eight new brominated diterpenes (1-8), featuring the rare dactylomelane skeleton, together with the previously reported luzodiol (9). The structure elucidation and the assignment of the relative configurations of the new natural products were based on extensive NMR spectroscopic and MS spectrometric analyses. Compounds 1-9 were evaluated for their cytotoxic activities against five human tumor cell lines, but were proven inactive.
authors: †Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors: Anastasia
authors: A
authors: Petraki
authors: †Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors: Efstathia
authors: E
authors: Ioannou
authors: ‡Department of Animal and Human Physiology, Faculty of Biology, School of Science, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece.
authors: Panagiota
authors: P
authors: Papazafiri
authors: †Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors: Vassilios
authors: V
authors: Roussis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001048:Aplysia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006115:Greece; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D006842:Hydrocarbons, Brominated; C505295:luzodiol