title: Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma.
abstract: BRAF V600E mutations have been reported in several histiocytic and dendritic cell neoplasms. In this case series, we report BRAF V600E-positive histiocytic and dendritic cell neoplasms in association with lymphomas and lymphoid proliferations. This is a review of cases with immunohistochemistry for BRAF V600E, with additional immunohistochemistry to categorize tumors. We report the first case of BRAF V600E-positive indeterminate cell tumor in association with angioimmunoblastic T-cell lymphoma. We also report a case of BRAF V600E-positive interdigitating dendritic cell sarcoma in a patient with positive B-cell polymerase chain reaction. It is unclear if these neoplasms developed as transdifferentiation of lymphoid neoplasms or if they developed independently. These cases illustrate the expanding spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors and suggest that attention should be paid to lymphomas for possible coincident presentation of these disorders.
authors: Clarient Pathology Services, Aliso Viejo, CA; MD Anderson Cancer Center, University of Texas, Houston, TX. Electronic address: dennis.omalley@ge.com.
authors: Dennis P
authors: DP
authors: O'Malley
authors: Clarient Pathology Services, Aliso Viejo, CA.
authors: Renuka
authors: R
authors: Agrawal
authors: Clarient Pathology Services, Aliso Viejo, CA.
authors: Kate E
authors: KE
authors: Grimm
authors: Clarient Pathology Services, Aliso Viejo, CA.
authors: Jennifer
authors: J
authors: Hummel
authors: Department of Pathology, Truman Medical Center, Kansas City, MO.
authors: Alexey
authors: A
authors: Glazyrin
authors: University of Missouri-Kansas City, Kansas City, MO.
authors: Daniel C
authors: DC
authors: Dim
authors: Department of Pathology, Truman Medical Center, Kansas City, MO.
authors: Sheshadri
authors: S
authors: Madhusudhana
authors: Clarient Pathology Services, Aliso Viejo, CA.
authors: Lawrence M
authors: LM
authors: Weiss
mesh_terms: D001402:B-Lymphocytes / Q000201:enzymology / Q000473:pathology; D054338:Cell Transdifferentiation / Q000502:physiology; D054739:Dendritic Cell Sarcoma, Interdigitating / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006646:Histiocytosis, Langerhans-Cell / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000201:enzymology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: BRAF V600E; Indeterminate cell tumor; Interdigitating dendritic cell sarcoma; Langerhans cell histiocytosis