title: The role of YY1 in oncogenesis and its potential as a drug target in cancer therapies.
abstract: Yin Yang 1 (YY1) is a multifunctional protein regulating both gene transcription and protein modifications. Recent studies reveal a proliferative role of YY1 in oncogenesis. Consistently, YY1 overexpression has been observed in various human malignancies and its levels correlate with poor prognoses of many types of cancers. In this review, we focus on the signaling pathways and regulatory proteins that YY1 modulates to promote tumor cell growth, proliferation, migration and metastasis. We also discuss the signals and molecules that regulate YY1 expression and function in cancer-related context. Based on the expression feature and regulatory activities in tumor cells, YY1 possesses a great potential as a biomarker for many cancers and can serve as a therapeutic target clinically to impede cancer development and progression or sensitize cancer cells to anticancer drugs.
authors: Jinming
authors: J
authors: Shi
authors: Aixin
authors: A
authors: Hao
authors: Qiang
authors: Q
authors: Zhang
authors: College of Life Science, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China. gcsui@nefu.edu.cn.
authors: Guangchao
authors: G
authors: Sui
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000378:metabolism; D063646:Carcinogenesis / Q000187:drug effects / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D050986:YY1 Transcription Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D050986:YY1 Transcription Factor; C494698:YY1 protein, human