title: Fully Implantable Deep Brain Stimulation System with Wireless Power Transmission for Long-term Use in Rodent Models of Parkinson's Disease.
abstract: OBJECTIVE
  The purpose of this study to develop new deep-brain stimulation system for long-term use in animals, in order to develop a variety of neural prostheses.
  
  
  METHODS
  Our system has two distinguished features, which are the fully implanted system having wearable wireless power transfer and ability to change the parameter of stimulus parameter. It is useful for obtaining a variety of data from a long-term experiment.
  
  
  RESULTS
  To validate our system, we performed pre-clinical test in Parkinson's disease-rat models for 4 weeks. Through the in vivo test, we observed the possibility of not only long-term implantation and stability, but also free movement of animals. We confirmed that the electrical stimulation neither caused any side effect nor damaged the electrodes.
  
  
  CONCLUSIONS
  We proved possibility of our system to conduct the long-term pre-clinical test in variety of parameter, which is available for development of neural prostheses.
authors: Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea.
authors: Man Seung
authors: MS
authors: Heo
authors: Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea.
authors: Hyun Seok
authors: HS
authors: Moon
authors: Interdisciplinary Program, Bioengineering Major, Graduate School, Seoul National University, Seoul, Korea. ; Department of Biomedical Engineering, College of Medicine and Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea.
authors: Hee Chan
authors: HC
authors: Kim
authors: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors: Hyung Woo
authors: HW
authors: Park
authors: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors: Young Hoon
authors: YH
authors: Lim
authors: Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
authors: Sun Ha
authors: SH
authors: Paek
keywords: Deep-brain stimulation; Implantable system; Wearable wireless power transfer