title: Renal denervation--hypes and hopes.
abstract: Catheter-based renal denervation (RDN) is a novel invasive approach in the treatment of resistant hypertension. It is considered a minimally invasive and safe procedure which, as shown by initial experimental and clinical trials, is able not only to reduce blood pressure but also to modify its risk factors by modulation of autonomic nervous system. Recently published results of a randomized Symplicity HTN-3 trial, which failed to demonstrate RDN-induced reduction of blood pressure at six months, decreased the initial enthusiasm regarding RDN and raised a question about real efficacy of this procedure. Nevertheless, still there are some other conditions characterized by increased sympathetic tone such as heart failure, atrial fibrillation, or ventricular arrhythmias that may benefit from RDN. Furthermore, novel therapeutical approach toward RDN using adapted electrophysiological or new specially designed electrodes may improve effectiveness of RDN procedure.
authors: Department of Electrocardiology, Sterling Regional Heart Disease Center, Medical University, Lodz, Poland.
authors: Joanna
authors: J
authors: Lewek
authors: Department of Electrocardiology, Sterling Regional Heart Disease Center, Medical University, Lodz, Poland.
authors: Krzysztof
authors: K
authors: Kaczmarek
authors: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Evgeniy
authors: E
authors: Pokushalov
authors: State Research Institute of Circulation Pathology, Novosibirsk, Russia.
authors: Alexandr
authors: A
authors: Romanov
authors: Department of Electrocardiology, Sterling Regional Heart Disease Center, Medical University, Lodz, Poland.
authors: Iwona
authors: I
authors: Cygankiewicz
authors: Department of Electrocardiology, Sterling Regional Heart Disease Center, Medical University, Lodz, Poland.
authors: Pawel
authors: P
authors: Ptaszynski
mesh_terms: D001794:Blood Pressure; D017115:Catheter Ablation; D003714:Denervation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D007668:Kidney / Q000294:innervation*
keywords: Autonomic nervous system; renal denervation; resistant hypertension