title: Consequences of Disrupted Notch Signaling in Bladder Cancer.
abstract: The Notch pathway, which controls stem cell maintenance and cell differentiation, is activated in certain cancers and therefore constitutes a therapeutic target. Especially in invasive urothelial carcinoma, the pathway is inactivated instead, and drugs inhibiting Notch signaling are likely contra-indicated.
authors: Department of Urology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors: Annemarie
authors: A
authors: Greife
authors: Department of Urology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
authors: Michèle J
authors: MJ
authors: Hoffmann
authors: Department of Urology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address: wolfgang.schulz@uni-duesseldorf.de.
authors: Wolfgang A
authors: WA
authors: Schulz
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D051880:Receptors, Notch / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins