title: Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations and breast cancer risk in the Cancer de Màma (CAMA) study.
abstract: OBJECTIVE
  We investigated the association between adherence to the recommendations of the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and breast cancer (BC) risk in the Cancer de Màma (CAMA) study in a Mexican population.
  
  
  METHODS
  Population-based case-control study.
  
  
  METHODS
  Incident BC cases (n 1000) and controls (n 1074) matched on age, region and health-care system were recruited.
  
  
  METHODS
  In-person interviews were conducted to assess BC risk factors and habitual diet was assessed with an FFQ. Conformity to the WCRF/AICR recommendations was evaluated through a score incorporating seven WCRF/AICR components (body fatness, physical activity, foods and drinks that promote weight gain, plant foods, animal foods, alcoholic drinks and breast-feeding), with high scores indicating adherence to the WCRF/AICR recommendations.
  
  
  RESULTS
  No statistically significant associations between WCRF/AICR score and risk of BC were observed. After excluding BMI from the WCRF/AICR score, the top quartile was associated with a decreased BC risk overall, with ORQ4-Q1=0.68 (95% CI 0.49, 0.92, P trend=0.03), and among postmenopausal women, with ORQ4-Q1=0.60 (95% CI 0.39, 0.94, P trend=0.03). Inverse associations were observed between BMI and risk of BC overall and among premenopausal women, with OR=0.57 (95% CI 0.42, 0.76, P trend <0.01) and 0.48 (95% CI 0.31, 0.73, P trend<0.01), respectively. Physical activity level was inversely associated with BC risk.
  
  
  CONCLUSIONS
  The WCRF/AICR index was not related with BC risk in the CAMA study. A combination of six components excluding BMI showed strong protective associations, particularly in postmenopausal women. Further prospective studies are required to clarify the role of adherence to WCRF/AICR recommendations, particularly with respect to BMI, in the Mexican population.
authors: 1Nutrition and Metabolism Section,International Agency for Research on Cancer (IARC),150 cours Albert Thomas,F-69372 Lyon Cedex 08,France.
authors: Anouar
authors: A
authors: Fanidi
authors: 1Nutrition and Metabolism Section,International Agency for Research on Cancer (IARC),150 cours Albert Thomas,F-69372 Lyon Cedex 08,France.
authors: Pietro
authors: P
authors: Ferrari
authors: 1Nutrition and Metabolism Section,International Agency for Research on Cancer (IARC),150 cours Albert Thomas,F-69372 Lyon Cedex 08,France.
authors: Carine
authors: C
authors: Biessy
authors: 2Instituto Nacional de Salud Publica,Cuernavaca,Mexico.
authors: Carolina
authors: C
authors: Ortega
authors: 2Instituto Nacional de Salud Publica,Cuernavaca,Mexico.
authors: Angélica
authors: A
authors: Angeles-Llerenas
authors: 2Instituto Nacional de Salud Publica,Cuernavaca,Mexico.
authors: Gabriella
authors: G
authors: Torres-Mejia
authors: 1Nutrition and Metabolism Section,International Agency for Research on Cancer (IARC),150 cours Albert Thomas,F-69372 Lyon Cedex 08,France.
authors: Isabelle
authors: I
authors: Romieu
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control*; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D004032:Diet / Q000009:adverse effects / Q000208:ethnology; D004038:Diet, Reducing / Q000208:ethnology; D005247:Feeding Behavior / Q000208:ethnology; D005260:Female; D006801:Humans; D015994:Incidence; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009043:Motor Activity; D018673:Nutrition Policy; D050177:Overweight / Q000208:ethnology / Q000503:physiopathology / Q000517:prevention & control / Q000628:therapy; D010349:Patient Compliance / Q000208:ethnology; D012307:Risk Factors; D057185:Sedentary Behavior / Q000208:ethnology
keywords: Breast cancer; Diet; Mexican women; Physical activity; Weight management