title: [Towards eradication of human immunodeficiency virus (HIV)?].
abstract: Antiretroviral therapy has led to massive improvement in the prognosis of HIV-infected patients. In France, more than 80% of patients have suppressed HIV viremia and prolonged survival. However, current antiretroviral strategies are unable to eradicate HIV, and treatment therefore has to be maintained for life, raising issues of long-term toxicity, comorbidities, resistance, and cost. Several factors explain our inability to eradicate HIV including viral latency in long-lived memory T cells, the persistence of immune activation despite suppression of viral replication in plasma, and persistent low-level viral replication in different compartments. Various international research strategies are currently addressing these issues with the ultimate aim of finding a cure.
authors: Christine
authors: C
authors: Katlama
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D017735:Virus Latency / Q000502:physiology; D014779:Virus Replication / Q000502:physiology
chemical_list: D044966:Anti-Retroviral Agents