title: Anti-inflammatory effects ofCordycepsmycelium (Paecilomyces hepiali, CBG-CS-2) in Raw264.7 murine macrophages.
abstract: Cordyceps(CS) is a traditional Chinese herb with various biological effects that include immune modulation. CBG-CS-2 is a strain,Paecilomyces hepiali, of theCordycepsspp. The anti-inflammatory effects of CBG-CS-2 were investigated. The water-soluble fraction of CBG-CS-2 has high anti-inflammatory activity in LPS-induced Raw264.7 macrophages. We tested the role of CBG-CS-2 on the anti-inflammation cascade in LPS-stimulated Raw264.7 cells. CBG-CS-2 significantly decreased NO production, iNOS expression, and pro-inflammatory cytokine secretion in a dose-dependent manner. To investigate the mechanism by which CBG-CS-2 inhibits NO, iNOS, and pro-inflammatory cytokines, we examined the activities of NF-κB and AP-1 in LPS-activated macrophages. The results demonstrate that CBG-CS-2 suppresses the production and expression of NO, iNOS, and pro-inflammatory cytokines in LPS-activated macrophages via inhibition of NF-κB and AP-1, which may play an important role in inflammation. These findings suggest that CBG-CS-2 has modulatory effects on the inflammatory system in macrophages, and that it can serve as a useful anti-inflammatory dietary supplement or drug.
authors: Department of Dental Pharmacology and Wonkwang Dental Research Institute, School of Dentistry, Wonkwang University, Iksan, 570-749 Republic of Korea.
authors: Seong-Yeol
authors: SY
authors: Park
authors: Clinical Trial Center for Functional Foods (CTCF2), Chonbuk National University Hospital, 20, Geonjiro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712 Republic of Korea.
authors: Su-Jin
authors: SJ
authors: Jung
authors: Healthcare Claims & Management Inc., 758, Baekjedaero, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-832 Republic of Korea.
authors: Ki-Chan
authors: KC
authors: Ha
authors: CHEBIGEN Inc., 111-18, Wonjangdong-gil, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-360 Republic of Korea.
authors: Hong-Sig
authors: HS
authors: Sin
authors: CHEBIGEN Inc., 111-18, Wonjangdong-gil, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-360 Republic of Korea.
authors: Seung-Hwan
authors: SH
authors: Jang
authors: Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, deokjin-gu, Jeonju-si, Jeollabuk-do 561-756 Republic of Korea.
authors: Han-Jung
authors: HJ
authors: Chae
authors: Clinical Trial Center for Functional Foods (CTCF2), Chonbuk National University Hospital, 20, Geonjiro, Deokjin-gu, Jeonju-si, Jeollabuk-do 561-712 Republic of Korea ; Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, deokjin-gu, Jeonju-si, Jeollabuk-do 561-756 Republic of Korea.
authors: Soo-Wan
authors: SW
authors: Chae
keywords: Anti-inflammation; CBG-CS-2; Cordyceps; Paecilomyces hepiali