title: Identification and characterization of β-sitosterol target proteins.
abstract: β-Sitosterol is the most abundant plant sterol in the human diet. It is also the major component of several traditional medicines, including saw palmetto and devil's claw. Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. Here, we report the identification of two new binding proteins for β-sitosterol that may underlie its beneficial effects.
authors: Department of Molecular and Medical Pharmacology, 23-231 Center for Health Sciences, 650 Charles E Young Dr. South, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: blomenick@mednet.ucla.edu.
authors: Brett
authors: B
authors: Lomenick
authors: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
authors: Heping
authors: H
authors: Shi
authors: Department of Molecular and Medical Pharmacology, 23-231 Center for Health Sciences, 650 Charles E Young Dr. South, University of California Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: jinghuang@mednet.ucla.edu.
authors: Jing
authors: J
authors: Huang
authors: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address: chuo.chen@utsouthwestern.edu.
authors: Chuo
authors: C
authors: Chen
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008968:Molecular Conformation; D064029:Peroxisomal Multifunctional Protein-2 / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D012855:Sitosterols / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D050863:Synaptotagmin I / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D012855:Sitosterols; D050863:Synaptotagmin I; C025473:gamma-sitosterol; D064029:Peroxisomal Multifunctional Protein-2
keywords: 17β-HSD4; E-Syt1; Phytosterol; Target identification; β-Sitosterol