title: Stereocontrol in nucleophilic substitution reactions at silicon: the role of permutation in generating silicon-centered chirality.
abstract: Intramolecular isomerization in pentacoordinate compounds can play an essential role for the adjustment of defined stereochemical information. Here, we present a conclusive mechanism of a stereocontrolled reaction on chiral dimethoxysilanes that opens new aspects in understanding the origin of creating silicon-centered chirality during a nucleophilic substitution process. By combining experimental, structural, and quantum chemical methods, we were able to disclose an interconversion process, based on consecutive Berry-type motions, as the most plausible mechanism for describing the stereochemical outcome in suchlike substitution reactions.
authors: Anorganische Chemie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany.
authors: Jonathan O
authors: JO
authors: Bauer
authors: Anorganische Chemie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany.
authors: Carsten
authors: C
authors: Strohmann