title: Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
abstract: Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes. Furthermore, Hook proteins are associated with pathological hallmarks in AD; Hook1 and Hook3 are localized to tau aggregates and Hook2 to glial components within amyloid plaques. Additionally, the expression of Hook3 is reduced in AD. Modelling of Hook3 deficiency in cultured cells leads to slowing of endosomal transport and increases β-amyloid production. We propose that Hook3 plays a role in pathogenic events exacerbating AD.
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Lydia
authors: L
authors: Herrmann
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Caspar
authors: C
authors: Wiegmann
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Annika
authors: A
authors: Arsalan-Werner
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Isabel
authors: I
authors: Hilbrich
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Carsten
authors: C
authors: Jäger
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Katharina
authors: K
authors: Flach
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Anne
authors: A
authors: Suttkus
authors: AJ Roboscreen GmbH, Leipzig, Germany.
authors: Ingolf
authors: I
authors: Lachmann
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Thomas
authors: T
authors: Arendt
authors: Paul Flechsig Institute of Brain Research, Department of Molecular and Cellular Mechanism of Neurodegeneration, University of Leipzig, Leipzig, Germany.
authors: Max
authors: M
authors: Holzer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002460:Cell Line; D015536:Down-Regulation; D011992:Endosomes / Q000378:metabolism; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; C521349:Hook2 protein, human; D008869:Microtubule-Associated Proteins; C471055:hook1 protein, human; C425466:hook3 protein, human