title: Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study.
abstract: Surface-enhanced Raman scattering (SERS) spectra were obtained from urine samples from subjects diagnosed with prostate cancer as well as from healthy controls, using Au nanoparticles as substrates. Principal component analysis (PCA) of the spectral data, followed by linear discriminant analysis (LDA), leads to a classification model with a sensitivity of 100 %, a specificity of 89 %, and an overall diagnostic accuracy of 95 %. Even considering the very limited number of samples involved in this report, preliminary results from this approach are extremely promising, encouraging further investigation.
authors: Department of Engineering and Architecture, University of Trieste, Via Valerio 6a, 34127, Trieste, TS, Italy.
authors: Greta
authors: G
authors: Del Mistro
authors: Silvia
authors: S
authors: Cervo
authors: Elena
authors: E
authors: Mansutti
authors: Riccardo
authors: R
authors: Spizzo
authors: Alfonso
authors: A
authors: Colombatti
authors: Pietro
authors: P
authors: Belmonte
authors: Renzo
authors: R
authors: Zucconelli
authors: Agostino
authors: A
authors: Steffan
authors: Valter
authors: V
authors: Sergo
authors: Alois
authors: A
authors: Bonifacio
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D016002:Discriminant Analysis; D006046:Gold / Q000737:chemistry; D006801:Humans; D019271:Hypoxanthine / Q000652:urine; D008297:Male; D008875:Middle Aged; D053758:Nanoparticles / Q000737:chemistry; D025341:Principal Component Analysis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000652:urine*; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D019271:Hypoxanthine; D006046:Gold