title: Basal glucosuria is ubiquitous in critically ill patients.
abstract: The 'renal threshold for glucose' has never been evaluated in critically ill patients. Therefore, we aimed to investigate the renal glucose threshold in this patient group using high-sensitivity urine glucose assays. In this retrospective analysis of prospectively collected data, we analysed 100 consecutive critically ill patients from a medical intensive care unit (ICU). Arterial blood glucose and spot urine glucose were simultaneously quantified daily during the first week after ICU admission. Three hundred seventy-three pairs of blood/urine glucose were plotted in five pre-defined categories of blood glucose (<80, 80-109, 110-139, 140-179 and ≥180 mg/dL). Urine glucose values of the five categories were compared using the Kruskal-Wallis test to assess the relation with blood glucose. Urine glucose was detected in virtually all of the urine samples. Urine glucose showed a positive nonlinear correlation with blood glucose and was significantly elevated at blood glucose levels of 140-179 and ≥180 mg/dL compared with lower blood glucose ranges. Basal glucosuria is ubiquitous in critically ill patients. A 'soft' renal threshold for glucose is present at blood glucose levels in the range of 140-179 mg/dL.
authors: Department of Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria.
authors: Richard
authors: R
authors: Brunner
authors: Annabella
authors: A
authors: Kurz
authors: Gabriel
authors: G
authors: Adelsmayr
authors: Ulrike
authors: U
authors: Holzinger
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000032:analysis; D016638:Critical Illness; D005260:Female; D005947:Glucose / Q000032:analysis*; D006029:Glycosuria / Q000097:blood / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015854:Up-Regulation; D016482:Urinalysis
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D005947:Glucose
keywords: critical care; glucose; intensive care; kidney; renal glucosuria