title: Clinical and Electroencephalographic (EEG) Features Associated With Refractoriness in Benign Childhood Epilepsy With Centrotemporal Spikes.
abstract: The aim of this study is to identify clinical or electroencephalographic (EEG) features associated with refractoriness to the initial antiepileptic drug in typical benign childhood epilepsy with centrotemporal spikes. A total of 87 children with typical benign childhood epilepsy with centrotemporal spikes were retrospectively reviewed in the analyses. The patients were subdivided into 2 groups: patients whose seizures were controlled with monotherapy and patients requiring 2 medications. Sixty-three children achieved seizure freedom with monotherapy, whereas 24 received 2 medications for seizure control. Diffusing foci at the follow-up EEG and delayed treatment (duration >1 year) are 2 main risk factors associated with more refractory cases (P < .001). Delayed diagnosis (37.1%) and nonadherence to treatment (57.2%) contributed to delayed treatment. Our findings suggested that diffusing foci on EEG and delayed treatment are associated with more frequent seizures and refractoriness in benign childhood epilepsy with centrotemporal spikes. Diagnostic delays and nonadherence hindered timely care, which may represent opportunities for improved intervention.
authors: Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, People's Republic of China.
authors: Fenglai
authors: F
authors: Xiao
authors: Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, People's Republic of China.
authors: Dongmei
authors: D
authors: An
authors: Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, People's Republic of China.
authors: Sihan
authors: S
authors: Chen
authors: Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, People's Republic of China.
authors: Jiechuan
authors: J
authors: Ren
authors: Department of Neurology, West China Hospital, SiChuan University, Chengdu, Sichuan, People's Republic of China zhoudong66@yahoo.de.
authors: Dong
authors: D
authors: Zhou
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D057210:Delayed Diagnosis; D000069279:Drug Resistant Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D004569:Electroencephalography; D019305:Epilepsy, Rolandic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance; D012189:Retrospective Studies; D012307:Risk Factors; D061665:Time-to-Treatment
chemical_list: D000927:Anticonvulsants
keywords: antiepileptic drugs; benign childhood epilepsy with centrotemporal spikes; clinical and electroencephalographic features; refractoriness; risk factor