title: Effect of the surface modification, size, and shape on cellular uptake of nanoparticles.
abstract: Nowadays successful application of nanoparticles for therapeutic objects needs the effective uptake of them by cells. Hence, studying of the interaction of nanoparticles with cell membrane for effective cellular uptaking seems to be vital and important. Trafficking of lipids, proteins, glucose, and other biomaterials into the cells is possible from two major exocytic and endocytic pathways. The penetration ability of nanoparticles into the cells must be considered in engineering of these particles. Enormous in vivo and in vitro experiments in the field of nanotechnology have confirmed the effect of physiochemistry properties in state of cell-nanoparticles interactions. Thus, the optimization of parameters directly related to physicochemical characteristics through the preparation process seems to be necessary for improving therapeutic effects of nanocarriers. Besides, biological medium and cell division also affect the amount of nanoparticle uptaking into the cells. This study reviews the influence of size, shape, the surface modification of nano particles, medium, and cell division effects on the cellular absorption of drug/gene nanocarriers.
authors: Biotechnology Research Center, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.|Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.|Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.
authors: Sara
authors: S
authors: Salatin
authors: Biotechnology Research Center, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.|Student Research Committee, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.|Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.
authors: Solmaz
authors: S
authors: Maleki Dizaj
authors: Drug Applied Research Center, Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.|Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Ahmad
authors: A
authors: Yari Khosroushahi
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D004337:Drug Carriers
keywords: drug delivery; endocytosis; nanosize; negative charge; neutral charge; positive charge