title: No changes in cerebral microcirculatory parameters in rat during local cortex exposure to microwaves.
abstract: The aim of this study was to determine whether cerebral microcirculatory parameters in rats were modified during local cortex exposure to a radiofrequency electromagnetic field (RF) under non-thermal conditions. The cortex tissue targeted was locally exposed to 1439 MHz RF using a figure-8 loop antenna at an averaged specific absorption rate of 2.0 W/kg in the target area for 50 min. Three microcirculatory parameters related to cerebral inflammation were measured by the cranial window method in real-time under RF exposure. No extravasation of intravenously injected fluorescent dye was observed during RF exposure. There was no significant difference either in pial venule blood flow velocity or diameter between exposed and sham-exposed rats. Histological evaluation for the brain immediately after RF exposure did not reveal any serum albumin leakage sites or degenerate neurons. These findings suggest that no dynamic changes occurred in cerebral microcirculation even during local cortex exposure under these conditions.
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan Department of Environmental Health, National Institute of Public Health, Saitama, Japan bdxmsd@yahoo.co.jp.
authors: Hiroshi
authors: H
authors: Masuda
authors: Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
authors: Shogo
authors: S
authors: Hirota
authors: Department of Environmental Health, National Institute of Public Health, Saitama, Japan.
authors: Akira
authors: A
authors: Ushiyama
authors: Department of Computer Science and Engineering, Nagoya Institute of Technology, Aichi, Japan.
authors: Akimasa
authors: A
authors: Hirata
authors: Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors: Takuji
authors: T
authors: Arima
authors: Department of Electrical and Electronics Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Watanabe
authors: Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors: Kanako
authors: K
authors: Wake
authors: Electromagnetic Compatibility Laboratory, Applied Electromagnetic Research Institute, National Institute of Information and Communications Technology, Tokyo, Japan.
authors: Soichi
authors: S
authors: Watanabe
authors: Department of Electrical and Electronic Engineering, Tokyo Metropolitan University, Tokyo, Japan.
authors: Masao
authors: M
authors: Taki
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Akiko
authors: A
authors: Nagai
authors: Department of Environmental Health, National Institute of Public Health, Saitama, Japan Japan EMF Information Center, Tokyo, Japan.
authors: Chiyoji
authors: C
authors: Ohkubo
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000528:radiation effects; D002540:Cerebral Cortex / Q000098:blood supply* / Q000528:radiation effects*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D004574:Electromagnetic Fields; D006439:Hemodynamics / Q000528:radiation effects; D008297:Male; D008833:Microcirculation / Q000528:radiation effects*; D008872:Microwaves; D010539:Permeability; D051381:Rats; D013696:Temperature
keywords: Radiofrequency electromagnetic field; blood–brain barrier; hemodynamics; local exposure; microcirculation