title: Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group.
abstract: In previous studies undertaken by our group, a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols (1a-r), which were analogs of fluconazole, was designed and synthesized by click chemistry. In the study reported here, the in vitro antifungal activities of all the target compounds were evaluated against eight human pathogenic fungi. Compounds 1a, 1q, and 1r showed the more antifungal activity than the others.
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Kehan
authors: K
authors: Xu
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Lei
authors: L
authors: Huang
authors: Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, People's Republic of China.
authors: Zheng
authors: Z
authors: Xu
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China ; Number 422 Hospital of PLA, Zhanjiang, People's Republic of China.
authors: Yanwei
authors: Y
authors: Wang
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Guojing
authors: G
authors: Bai
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Qiuye
authors: Q
authors: Wu
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Xiaoyan
authors: X
authors: Wang
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Shichong
authors: S
authors: Yu
authors: School of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors: Yuanying
authors: Y
authors: Jiang
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001593:Benzyl Compounds / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D001593:Benzyl Compounds; D014230:Triazoles
keywords: CYP51; antifungal activity; synthesis; triazole