title: Diagnosis of brain tumors using dynamic contrast-enhanced perfusion imaging with a short acquisition time.
abstract: This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5 min) in patients with glioma, brain metastasis, and primary CNS lymphoma (PCNSL). Twenty-six patients with 29 lesions (4 low-grade glioma, 13 high-grade glioma, 7 metastasis, and 5 PCNSL) underwent DCE-MRI in a 3 T scanner. A ROI was placed on the hotspot of each tumor in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p . We analyzed differences in parameters between tumors using the Mann-Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K (trans) values of LGG, HGG, metastasis and PCNSL were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each tumors was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each tumors was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other tumor types, low-grade glioma showed lower K (trans) (P < 0.01, sensitivity = 88%, specificity = 100%) and lower V e (P < 0.01, sensitivity = 96%, specificity = 100%). PCNSL showed higher V e (P < 0.01, sensitivity = 100%, specificity = 88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of brain tumors.
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Takashi
authors: T
authors: Abe
authors: Departments of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Yoshifumi
authors: Y
authors: Mizobuchi
authors: Departments of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Kohei
authors: K
authors: Nakajima
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Yoichi
authors: Y
authors: Otomi
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Saho
authors: S
authors: Irahara
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Yuki
authors: Y
authors: Obama
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Mungunkhuyag
authors: M
authors: Majigsuren
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Delgerdalai
authors: D
authors: Khashbat
authors: Departments of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Teruyoshi
authors: T
authors: Kageji
authors: Departments of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Shinji
authors: S
authors: Nagahiro
authors: Department of Radiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-cho, Tokushima City, Tokushima 770-8509 Japan.
authors: Masafumi
authors: M
authors: Harada
keywords: Brain tumor; Dynamic contrast enhanced (DCE) perfusion; Magnetic resonance imaging (MRI); Pharmacokinetic model analysis; Two-compartment model analysis