title: The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring.
abstract: BACKGROUND
  Trichilia catigua is broadly used in folk medicine due to its mental and physical tonic activities and stimulant effects. In animal models, its antidepressant-like effects have been associated with the dopaminergic (DA) system modulation, which has an important role on maternal behavior and male offspring reproductive development.
  
  
  OBJECTIVE
  Since little is known about the adverse effects of the exposure to T. catigua crude extract (CAT) in rats, specially regarding maternal homeostasis and offspring development, the aim of the present study was to evaluate whether CAT exposure may influence maternal toxicity parameters and behavior or disrupt male offspring physical and reproductive development.
  
  
  METHODS
  Dams were treated daily (by gavage) with 400mg/kg of CAT or vehicle (control=CTR) throughout pregnancy and lactation. Fertility and maternal behavior tests were conducted in dams. Male offspring reproductive and behavioral parameters were analyzed.
  
  
  RESULTS
  Dams exposed to CAT showed increased pre- and post-implantation losses rates when compared to CTR group. No significant changes regarding maternal behavior or male offspring parameters were observed.
  
  
  CONCLUSIONS
  In conclusion, maternal exposure to CAT interfered with implantation during the initial phases of pregnancy but did not induce changes on maternal behavior or male offspring reproductive and behavioral parameters.
authors: Department of Physiological Sciences, State University of Londrina, BR-86051-980 Londrina, Paraná, Brazil.
authors: Alice Hartmann
authors: AH
authors: Dos Santos
authors: Department of Physiological Sciences, State University of Londrina, BR-86051-980 Londrina, Paraná, Brazil.
authors: Aline Camargo
authors: AC
authors: Ramos
authors: Department of Physiological Sciences, State University of Londrina, BR-86051-980 Londrina, Paraná, Brazil.
authors: Kennia Moura
authors: KM
authors: Silveira
authors: Department of Physiology, São Paulo State University, BR-18618-970 Botucatu, São Paulo, Brazil.
authors: Ana Carolina Inhasz
authors: AC
authors: Kiss
authors: Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, BR-87020-900 Maringá, Paraná, Brazil.
authors: Renata
authors: R
authors: Longhini
authors: Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, BR-87020-900 Maringá, Paraná, Brazil.
authors: Andréa
authors: A
authors: Diniz
authors: Department of Pharmacy, State University of Maringá, Av. Colombo, 5790, BR-87020-900 Maringá, Paraná, Brazil.
authors: João Carlos Palazzo
authors: JC
authors: de Mello
authors: Department of Physiological Sciences, State University of Londrina, BR-86051-980 Londrina, Paraná, Brazil. Electronic address: dcgerardin@uel.br.
authors: Daniela Cristina Ceccatto
authors: DC
authors: Gerardin
mesh_terms: D000818:Animals; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D029582:Meliaceae / Q000009:adverse effects* / Q000737:chemistry*; D010936:Plant Extracts / Q000009:adverse effects* / Q000737:chemistry; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*
chemical_list: D010936:Plant Extracts
keywords: Dopamine; Embryotoxicity; Fertility; Maternal behavior; Trichilia catigua