title: A copper-catalyzed one-pot, three-component tandem conjugative alkynylation/6-endo cyclization sequence: access to pyrano[2,3-d]-pyrimidines.
abstract: A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in conjugative alkynylation reaction and the synthetic applicability of conjugative addition products under one-pot conditions were documented for the first time.
authors: Medicinal Chemistry Division, CSIR-North-East Institute of Science and Technology, Jorhat, Assam 785006, India. dr_dprajapati2003@yahoo.co.uk.
authors: Nimmakuri
authors: N
authors: Rajesh
authors: Dipak
authors: D
authors: Prajapati