title: Novel anticoagulants and antiplatelet agents; a guide for the urologist.
abstract: Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing population, with an increasing burden of complex comorbidities, urologists will frequently encounter patients who will be using such agents. Some background knowledge, and an understanding, of these drugs and the issues that surround their usage, is essential. The present article will provide readers with an understanding of these new drugs, including their mechanisms of action, the up-to-date evidence justifying their recent introduction into clinical practice and the appropriate interval for stopping them before surgery. It will also consider the risks of perioperative bleeding for patients taking these drugs and the risks of venous thromboembolism in those in whom they are stopped. Strategies to manage anticoagulant-associated bleeding are discussed.
authors: Department of Urology, Whittington Hospital, London, UK.
authors: Gidon
authors: G
authors: Ellis
authors: Department of Clinical Cardiology, St George's Healthcare NHS Trust, London, UK.
authors: Alan
authors: A
authors: John Camm
authors: Department of Urology, Colchester Hospital University Foundation Trust, Colchester, UK.
authors: Soumendra N
authors: SN
authors: Datta
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000494:pharmacology; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome; D013520:Urologic Surgical Procedures / Q000379:methods*; D014572:Urology; D054556:Venous Thromboembolism / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors
keywords: anticoagulants; antiplatelets; novel; oral