title: Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study.
abstract: BACKGROUND
  To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood.
  
  
  METHODS
  A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score.
  
  
  RESULTS
  Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1,5-anhydroglucitol (1,5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1,5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use.
  
  
  CONCLUSIONS
  White matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood.
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Mika
authors: M
authors: Yamawaki
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Kenji
authors: K
authors: Wada-Isoe
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Mikie
authors: M
authors: Yamamoto
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Satoko
authors: S
authors: Nakashita
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Yusuke
authors: Y
authors: Uemura
authors: Department of Health Informatics, Kyoto University School of Public Health Kyoto, Japan.
authors: Yoshimitsu
authors: Y
authors: Takahashi
authors: Department of Health Informatics, Kyoto University School of Public Health Kyoto, Japan.
authors: Takeo
authors: T
authors: Nakayama
authors: Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University Yonago, Japan.
authors: Kenji
authors: K
authors: Nakashima
mesh_terms: D000339:Affect / Q000502:physiology; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D001927:Brain Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D015897:Comorbidity; D003847:Deoxyglucose / Q000378:metabolism; D003863:Depression / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D007361:Intelligence Tests; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D066127:White Matter / Q000473:pathology*
chemical_list: C006584:1,5-anhydroglucitol; D003847:Deoxyglucose
keywords: Cognitive function; deep white matter hyperintensities; mood; periventricular hyperintensities; population based