title: [Efficacy and safety of the WT-2009 chemotherapy protocol in treatment of Wilms' tumor in children].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of the WT-2009 chemotherapy protocol for Wilms' tumor (WT) in children.
  
  
  METHODS
  The clinical data of 34 children with newly-diagnosed WT between July 2009 and December 2013 were retrospectively analyzed. Among the 34 children, 2 died before treatment, 6 children did not accept therapy and 26 accepted the chemotherapy based on the WT-2009 chemotherapy protocol. Kaplan-Meier method was used to estimate the 2-year survival rate.
  
  
  RESULTS
  The pathological analysis revealed the favorable histology WT was common (88%, 30/34). The most common first manifestation was abdominal masses (56%, 19/34). Among the 26 patients who accepted the chemotherapy based on the WT-2009 protocol, complete remission was achieved in 24 cases (92%), partial remission was achieved in 1 case (4%), and disease relapse was found in 1 case (4%). Severe pulmonary infection occurred in 1 case in the course of treatment. The 2-year overall survival rate and event-free survival rate were 100% and 89.7% respectively.
  
  
  CONCLUSIONS
  Favorable histology is most common pathological type in children with WT. The chemotherapy based on the WT-2009 protocol for WT can produce a favorable prognosis and a high tolerance.
authors: Department of Pediatrics, West China Second Hospital, Sichuan University, Chengdu 610041, China. zhuyiping918@qq.com.
authors: Xia
authors: X
authors: Guo
authors: Chao
authors: C
authors: Lin
authors: Ju
authors: J
authors: Gao
authors: Chen-Yan
authors: CY
authors: Zhou
authors: Qiang
authors: Q
authors: Li
authors: Yi-Ping
authors: YP
authors: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D015996:Survival Rate; D009396:Wilms Tumor / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents