title: The modulation of nicotinic acetylcholine receptors on the neuronal network oscillations in rat hippocampal CA3 area.
abstract: γ oscillations are associated with higher brain functions such as memory, perception and consciousness. Disruption of γ oscillations occur in various neuro-psychological disorders such as schizophrenia. Nicotinic acetylcholine receptors (nAChR) are highly expressed in the hippocampus, however, little is known about the role on hippocampal persistent γ oscillation. This study examined the effects of nicotine and selective nAChR agonists and antagonists on kainate-induced persistent γ oscillation in rat hippocampal slices. Nicotine enhanced γ oscillation at concentrations of 0.1-10 μM, but reduced it at a higher concentration of 100 μM. The enhancement on γ oscillation can be best mimicked by co-application of α4β2- and α7-nAChR agonist and reduced by a combination of nAChR antagonists, DhβE and MLA. However, these nAChR antagonists failed to block the suppressing role of nicotine on γ. Furthermore, we found that the NMDA receptor antagonist D-AP5 completely blocked the effect of nicotine. These results demonstrate that nicotine modulates γ oscillations via α7 and α4β2 nAChR as well as NMDA activation, suggesting that nAChR activation may have a therapeutic role for the clinical disorder such as schizophrenia, which is known to have impaired γ oscillation and hypo-NMDA receptor function.
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Yang
authors: Y
authors: Wang
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Zhan
authors: Z
authors: Wang
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Jiangang
authors: J
authors: Wang
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Yali
authors: Y
authors: Wang
authors: Institute of Membrane and System Biology, University of Leeds, Leeds, England.
authors: Zaineb
authors: Z
authors: Henderson
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Xiaofang
authors: X
authors: Wang
authors: Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China.
authors: Xi
authors: X
authors: Zhang
authors: Psychiatric Hospital of Henan Province, 2nd Affiliated Hospital of Xinxiang Medical University.
authors: Jinggui
authors: J
authors: Song
authors: 1] Key Laboratory for the Brain Research of Henan Province, Xinxiang Medical University, Henan Province, Henan PR. China [2] Psychiatric Hospital of Henan Province, 2nd Affiliated Hospital of Xinxiang Medical University.
authors: Chengbiao
authors: C
authors: Lu
mesh_terms: D000818:Animals; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects / Q000235:genetics*; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D009538:Nicotine / Q000378:metabolism; D018722:Nicotinic Agonists / Q000008:administration & dosage; D018733:Nicotinic Antagonists / Q000008:administration & dosage; D051381:Rats; D011978:Receptors, Nicotinic / Q000096:biosynthesis* / Q000235:genetics; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D064569:alpha7 Nicotinic Acetylcholine Receptor / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor; C403531:nicotinic receptor alpha4beta2; D009538:Nicotine