title: Prognostic value of hemostasis-related parameters for prediction of organ dysfunction and mortality in sepsis.
abstract: OBJECTIVE
  Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis- related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis.
  
  
  METHODS
  Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences between groups of septic patients were assessed by Mann-Whitney U test and Kruskal-Wallis test. Logistic regression analysis was performed to test the joint effect of different predictors.
  
  
  RESULTS
  Prolonged aPTT and PT with higher D-dimer concentrations in patients with sepsis are associated with more severe forms of the disease, aPTT was prolonged in nonsurvivors, while platelet count and fibrinogen levels were higher in survivors. Platelet count and aPTT ratio are independent predictors of fatal outcome in our logistic regression model.
  
  
  CONCLUSIONS
  Hemostasis-related parameters have a significant impact on severity and outcome in sepsis.
authors: Dunja
authors: D
authors: Mihajlovic
authors: Dajana
authors: D
authors: Lendak
authors: Gorana
authors: G
authors: Mitic
authors: Tatjana
authors: T
authors: Cebovic
authors: Biljana
authors: B
authors: Draskovic
authors: Aleksandra
authors: A
authors: Novakov
authors: Snezana
authors: S
authors: Brkic
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001780:Blood Coagulation Tests; D015331:Cohort Studies; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000453:epidemiology* / Q000209:etiology; D011379:Prognosis; D018805:Sepsis / Q000150:complications / Q000453:epidemiology / Q000401:mortality* / Q000503:physiopathology*; D012769:Shock; D055815:Young Adult