title: Can biomarkers help to diagnose early heart failure with preserved ejection fraction?
abstract: Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF.
authors: Department of Cardiovascular Diseases, St. Anne's Hospital, ICRC, 65691 Brno, Czech Republic ; Department of Cardiovascular Diseases, Masaryk University, Brno, Czech Republic.
authors: Jaroslav
authors: J
authors: Meluzín
authors: ICRC, Brno, Czech Republic ; Department of Biochemistry, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic.
authors: Josef
authors: J
authors: Tomandl
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D000071063:Endoglin; D037502:Galectin 3 / Q000097:blood*; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface / Q000097:blood*; D013318:Stroke Volume
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; C064206:ENG protein, human; D000071063:Endoglin; C526140:GDF15 protein, human; D037502:Galectin 3; D055436:Growth Differentiation Factor 15; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface; C092073:cardiotrophin 1