title: Puberty and perimenopause: reproductive transitions and their implications for women's health.
abstract: This scoping review synthesizes existing research on two major transitions in females' lives: puberty and perimenopause. These two periods of vast physiological change demarcate the beginning and the end of the reproductive life cycle and are associated with major neuroendocrine reorganization across two key systems, the hypothalamic-pituitary-gonadal (HPG) axis the hypothalamus-pituitary-adrenal (HPA) axis. Despite growing evidence suggesting that the timing and experience of puberty and perimenopause are related to various physical and mental health outcomes (e.g., mood disorders, metabolism, cardiovascular health, autoimmune conditions, and cancer), these two processes are rarely examined together. In this paper, we bridge these disparate literatures to highlight similarities, isolate inconsistencies, and identify important areas for future research in women's health.
authors: Robert Wood Johnson Foundation Health & Society Scholar at the University of California, San Francisco and Berkeley, 3333 California St., Suite 465, San Francisco, CA 94143, USA. Electronic address: hoytl@chc.ucsf.edu.
authors: Lindsay Till
authors: LT
authors: Hoyt
authors: School of Public Health, University of California, Berkeley, 13A University Hall, Berkeley, CA 94720, USA. Electronic address: april.falconi@berkeley.edu.
authors: April M
authors: AM
authors: Falconi
mesh_terms: D000367:Age Factors; D001327:Autoimmune Diseases / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D006304:Health Status; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008603:Mental Health; D009026:Mortality; D009369:Neoplasms / Q000453:epidemiology; D047648:Perimenopause / Q000502:physiology* / Q000523:psychology*; D010913:Pituitary-Adrenal System / Q000502:physiology; D011627:Puberty / Q000502:physiology* / Q000523:psychology*; D012741:Sexual Maturation; D016387:Women's Health
chemical_list: D006728:Hormones
keywords: Chronic disease; HPA axis; HPG axis; Life course health; Perimenopause; Puberty; Women's health