title: Advanced glycation end-products inhibitors isolated from Schisandra grandiflora.
abstract: Free radicals scavenging and advanced glycation end-products (AGEs) inhibitory potentials in crude chloroform extract of Schisandra grandiflora were evaluated. Bioassay-guided isolation of the chloroform extract led to the identification of 24 compounds. Among the isolates, ( ± ) gomisin M1, arisantetralone C and D, macelignan, saurulignan B and SZ-MO displayed potent-free radical scavenging as well as AGEs inhibitory potentials. This is the first report identifying the presence of AGEs inhibitory activity and assigning AGEs inhibitory activity to these compounds. Therefore, our research finds new application of traditional medicinal plant S. grandiflora having capacity to reduce formation and accumulation of AGEs in diabetes.
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: B
authors: B
authors: Poornima
authors: b Division of Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: D Anand
authors: DA
authors: Kumar
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: Bandi
authors: B
authors: Siva
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: A
authors: A
authors: Venkanna
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: P R Rao
authors: PR
authors: Vadaparthi
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: K
authors: K
authors: Kumar
authors: b Division of Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: Ashok K
authors: AK
authors: Tiwari
authors: a Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology , Tarnaka, Hyderabad 500 007 , India.
authors: K Suresh
authors: KS
authors: Babu
mesh_terms: D016166:Free Radical Scavengers / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*
chemical_list: D016166:Free Radical Scavengers; D017127:Glycation End Products, Advanced; D010936:Plant Extracts
keywords: Schisandra grandiflora; advanced glycation end-products inhibitor; diabetes; free radical scavenging activity