title: Physiology of the Renal Interstitium.
abstract: Long overlooked as the virtual compartment and then strictly characterized through descriptive morphologic analysis, the renal interstitium has finally been associated with function. With identification of interstitial renin- and erythropoietin-producing cells, the most prominent endocrine functions of the kidney have now been attributed to the renal interstitium. This article reviews the functional role of renal interstitium.
authors: Department of Nephrology and Rheumatology, Göttingen University Medical Center, Georg August University, Göttingen, Germany; and mzeisberg@med.uni-goettingen.de rkalluri@mdanderson.org.
authors: Michael
authors: M
authors: Zeisberg
authors: Department of Cancer Biology and the Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas mzeisberg@med.uni-goettingen.de rkalluri@mdanderson.org.
authors: Raghu
authors: R
authors: Kalluri
mesh_terms: D000241:Adenosine / Q000378:metabolism; D000740:Anemia / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D004921:Erythropoietin / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000166:cytology* / Q000196:embryology / Q000502:physiology* / Q000648:ultrastructure; D007674:Kidney Diseases / Q000503:physiopathology; D059630:Mesenchymal Stem Cells; D009432:Neural Crest; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology
chemical_list: C554270:EPO protein, human; D004921:Erythropoietin; D012083:Renin; D000241:Adenosine
keywords: erythropoietin; fibroblast; fibrosis; renal interstitium; renin angiotensin system