title: Arterial compliance may be reduced by ingestion of red wine.
abstract: The aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects (mean age 34.2 years, range 25-53). The subjects received the two days in random order. On the alcohol day, the subjects were asked to drink two glasses of red wine (12% ethanol) between 1830 hours and 0430 hours. Measurements of heart rate, blood pressure and QKD interval (Q wave to Korotkoff (K) sound, diastolic phase (D) using Diasys Integra (Novacor, France)) were recorded (usually 1500 hours to 1500 hours). Three 'ingestion' periods were defined, from 1500 hours to 1830 hours ('before'), 1900 hours to 0430 hours ('during') and from 0430 hours to the following afternoon ('after') on both the alcohol day and on the control day. Red wine increased heart rate during alcohol ingestion and reduced arterial compliance after ingestion. The significant effect of interaction between day and ingestion period on heart rate, diastolic blood pressure and QKD were found, suggesting that the differences in response among the ingestion periods depended on whether alcohol has been consumed that day. For the first time our study indicates the effect of alcohol on 24 h arterial stiffness in a healthy group of volunteers.
authors: Department of Medicine, Brighton and Sussex Medical School, Brighton, UK.|Department of Medicine, Section of Geriatrics, University of Verona, Verona, Italy.
authors: F
authors: F
authors: Fantin
authors: Department of Medicine, Imperial College School of Medicine, London, UK.
authors: C J
authors: CJ
authors: Bulpitt
authors: Department of Medicine, Section of Geriatrics, University of Verona, Verona, Italy.
authors: M
authors: M
authors: Zamboni
authors: Department of Medicine, Brighton and Sussex Medical School, Brighton, UK.
authors: E
authors: E
authors: Cheek
authors: Department of Medicine, Brighton and Sussex Medical School, Brighton, UK.
authors: C
authors: C
authors: Rajkumar
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D001158:Arteries / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires; D059289:Vascular Stiffness / Q000187:drug effects*; D014920:Wine