title: All-Cause Mortality up to and After Coronary Heart Disease and Stroke Events in European Middle-Aged Men: The PRIME Study.
abstract: OBJECTIVE
  The aim was to investigate prospectively the all-cause mortality risk up to and after coronary heart disease (CHD) and stroke events in European middle-aged men.
  
  
  METHODS
  The study population comprised 10 424 men 50 to 59 years of age recruited between 1991 and 1994 in France (N=7855) and Northern Ireland (N=2747) within the Prospective Epidemiological Study of Myocardial Infarction. Incident CHD and stroke events and deaths from all causes were prospectively registered during the 10-year follow-up. In Cox's proportional hazards regression analysis, CHD and stroke events during follow-up were used as time-dependent covariates.
  
  
  RESULTS
  A total of 769 CHD and 132 stroke events were adjudicated, and 569 deaths up to and 66 after CHD or stroke occurred during follow-up. After adjustment for study country and cardiovascular risk factors, the hazard ratios of all-cause mortality were 1.58 (95% confidence interval 1.18-2.12) after CHD and 3.13 (95% confidence interval 1.98-4.92) after stroke.
  
  
  CONCLUSIONS
  These findings support continuous efforts to promote both primary and secondary prevention of cardiovascular disease.
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Bilal
authors: B
authors: Majed
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Michèle
authors: M
authors: Montaye
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Aline
authors: A
authors: Wagner
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Dominique
authors: D
authors: Arveiler
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Pierre
authors: P
authors: Ducimetiere
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Muriel
authors: M
authors: Tafflet
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Jean
authors: J
authors: Ferrieres
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Jean-Bernard
authors: JB
authors: Ruidavets
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Frank
authors: F
authors: Kee
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Alun
authors: A
authors: Evans
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Philippe
authors: P
authors: Amouyel
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Christof
authors: C
authors: Prugger
authors: From the INSERM, U970, Paris Cardiovascular Research Center, University Paris Descartes, Sorbonne Paris Cité, Paris, France (B.M., M.T., C.P., J.-P.E.); The Lille MONICA Project, INSERM, U1167, Institut Pasteur de Lille, Université Nord de France, UDSL, Lille, 5900, France (M.M., P.A.); The Strasbourg MONICA Project, Laboratoire d'Épidémiologie et de Santé Publique, EA 3430, Fédération de Médecine Translationnelle de Strasbourg, Université de Strasbourg, Strasbourg, France (A.W., D.A.); INSERM-Université Paris-Sud XI, Villejuif, France (P.D.); The Toulouse MONICA Project, UMR INSERM 1027, Département d'Épidémiologie et de Santé Publique, Université Paul Sabatier, Toulouse Purpan, Toulouse, France (J.F., J.-B.R.); and The UKCRC, Center of Excellence for Public Health (NI), The Queen's University, Belfast-Northern Ireland (F.K., A.E.).
authors: Jean-Philippe
authors: JP
authors: Empana
mesh_terms: D016001:Confidence Intervals; D003327:Coronary Disease / Q000401:mortality*; D005060:Europe / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000401:mortality*
keywords: cardiovascular disease; epidemiology; prevention; survival analysis