title: Endosome traffic machinery meets the p53-p21 axis.
abstract: SIRT1 regulates p53 transcriptional activation in response to genotoxic insult by deacetylating key lysine residues. We recently identified the multifunctional protein PACS-2 as a SIRT1 inhibitor. After DNA damage, PACS-2 binds and inhibits SIRT1 to increase p53-dependent transactivation of the CDK inhibitor p21 (CDKN1A) and induce cell cycle arrest.
authors: Department of Microbiology and Molecular Genetics; University of Pittsburgh School of Medicine; Pittsburgh, PA USA.
authors: Jonathan
authors: J
authors: Barroso-González
authors: Department of Microbiology and Molecular Genetics; University of Pittsburgh School of Medicine; Pittsburgh, PA USA.
authors: Gary
authors: G
authors: Thomas
keywords: DNA damage response; PACS-2; SIRT1; cell cycle arrest; p21p53