title: Left ventricular mass regression after two alternative sutureless aortic bioprostheses.
abstract: OBJECTIVE
  Left ventricular (LV) hypertrophy in aortic stenosis (AS) constitutes a risk factor for cardiac morbidity and mortality. The aim of this study was to investigate the degree of LV mass regression after aortic valve replacement (AVR) with two alternative sutureless self-expanding strategies: Perceval S (Sorin Group, Saluggia, Italy) (P) and 3f Enable (Medtronic, ATS Medical, Minneapolis, MN USA) (E) aortic bioprostheses.
  
  
  METHODS
  Between March 2010 and December 2011, 129 patients with symptomatic AS underwent AVR with the Perceval S or 3f Enable bioprostheses in two cardiac surgery departments (Massa, Italy; Nuremberg, Germany). We analyzed 45 patients in group P and 19 in group E undergoing isolated AVR with a 6-month follow-up. The LV mass was calculated using the Devereux formula and was indexed to body surface area.
  
  
  RESULTS
  Baseline patient characteristics showed no significant differences between the two groups. There were no in-hospital deaths. Two patients in group P died at follow-up versus zero in group E (P = 0.49). Mean LV mass index decreased from 146.6 (78) g/m at baseline to 123.3 (63) g/m at follow-up (P < 0.001) in group P and from 146.1 (47.6) g/m to 118.1 (39.8) g/m (P = 0.003) in group E, with no significant difference between the two groups (P = 0.315). This effect was accompanied by significant clinical improvement.
  
  
  CONCLUSIONS
  In isolated AS, AVR with sutureless bioprostheses is associated with a significant regression in LV mass at 6-month follow-up. No significant differences were present between the two alternative sutureless strategies. However, regression needs an evaluation with long-term echocardiographic examinations.
authors: From the *Department of Cardiac Surgery, Ospedale del Cuore "G. Pasquinucci" - Fondazione Monasterio-CNR, Massa, Italy; and †Department of Cardiac Surgery, Cardiovascular Center - Paracelsus Medical University, Nuremberg, Germany.
authors: Giovanni
authors: G
authors: Concistrè
authors: Francesca
authors: F
authors: Chiaramonti
authors: Giuseppe
authors: G
authors: Santarpino
authors: Steffen
authors: S
authors: Pfeiffer
authors: Federica
authors: F
authors: Marchi
authors: Ferdinand
authors: F
authors: Vogt
authors: Antonio
authors: A
authors: Miceli
authors: Mattia
authors: M
authors: Glauber
authors: Theodor
authors: T
authors: Fischlein
authors: Marco
authors: M
authors: Solinas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D001705:Bioprosthesis; D004452:Echocardiography / Q000379:methods; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D013536:Suture Techniques; D016896:Treatment Outcome; D020257:Ventricular Remodeling