title: Aminoacyl-tRNA synthetase complexes in evolution.
abstract: Aminoacyl-tRNA synthetases are essential enzymes for interpreting the genetic code. They are responsible for the proper pairing of codons on mRNA with amino acids. In addition to this canonical, translational function, they are also involved in the control of many cellular pathways essential for the maintenance of cellular homeostasis. Association of several of these enzymes within supramolecular assemblies is a key feature of organization of the translation apparatus in eukaryotes. It could be a means to control their oscillation between translational functions, when associated within a multi-aminoacyl-tRNA synthetase complex (MARS), and nontranslational functions, after dissociation from the MARS and association with other partners. In this review, we summarize the composition of the different MARS described from archaea to mammals, the mode of assembly of these complexes, and their roles in maintenance of cellular homeostasis.
authors: Laboratoire d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Université Paris-Sud, 1 avenue de la Terrasse, 91190 Gif-sur-Yvette, France. svitlana.havrylenko@curie.fr.
authors: Svitlana
authors: S
authors: Havrylenko
authors: Laboratoire d'Enzymologie et Biochimie Structurales (LEBS), CNRS, Université Paris-Sud, 1 avenue de la Terrasse, 91190 Gif-sur-Yvette, France. marc.mirande@lebs.cnrs-gif.fr.|Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, 1 avenue de la Terrasse, 91190 Gif-sur-Yvette, France. marc.mirande@lebs.cnrs-gif.fr.
authors: Marc
authors: M
authors: Mirande
mesh_terms: D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D001105:Archaea / Q000201:enzymology / Q000378:metabolism; D005075:Biological Evolution; D010802:Phylogeny
chemical_list: D000604:Amino Acyl-tRNA Synthetases