title: [Actomyosin ATPase activity of skeletal muscles and the markers of tissue damage in the blood of rats under prolonged chronic alcoholization].
abstract: The activity of creatine kinase and indices of lipid metabolism in the blood and also actomyosin ATPase activity of skeletal muscles of rats under chronic 8-month alcohol abuse were investigated. It is shown that actomyosin K+-ATPase activity of skeletal muscles increases from two months of ethanol use, but actomyosin Mg2+-ATPase activity decreases during 6-8 months of alcoholization. From two months of ethanol use the creatine kinase activity, as an enzyme marker of muscle tissue damage, statistically significantly increases during all the period of the animals alcoholization. The level of total lipid increases after two months of alcohol consumption (in blood plasma by 30% and in erythrocyte mass by 65%). For longer periods of alcoholization (4-8 months) the level of lipids remains almost the same, whereas in erythrocyte mass it does not differ from control values. The level of diene conjugates in the blood plasma reduces and the amount of ketone derivatives of fatty acid residues increases that points to the inhibition of some components of the antioxidant system that control detoxification of hydroperoxides of fatty acids and also to activation of free radical damage of tissues. There were no significant changes of lipid peroxidation level in erythrocyte mass at any stage of alcoholization.
authors: Iu V
authors: IuV
authors: Tseĭslier
authors: O M
authors: OM
authors: Podpalova
authors: N Ie
authors: NIe
authors: Nuryshchenko
authors: V S
authors: VS
authors: Martyniuk
mesh_terms: D008841:Actin Cytoskeleton / Q000737:chemistry / Q000187:drug effects; D000437:Alcoholism / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D052283:Creatine Kinase, MM Form / Q000378:metabolism; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology; D009218:Myosins / Q000145:classification / Q000378:metabolism*; D051381:Rats
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D000431:Ethanol; D052283:Creatine Kinase, MM Form; D009218:Myosins