title: Vascular-targeted photodynamic therapy with TOOKAD® Soluble in localized prostate cancer: standardization of the procedure.
abstract: BACKGROUND
  Vascular-targeted photodynamic therapy with TOOKAD(®) Soluble is an innovative focal therapy procedure assessed in localized prostate cancer treatment.
  
  
  METHODS
  This mini-invasive technique destroys targeted tissues using a photosensitizer [TOOKAD(®) Soluble (WST11), STEBA Biotech] activated by laser light in the presence of oxygen. Its application for prostate cancer requires intravenous infusion of TOOKAD(®) Soluble and the illumination of the targeted area by transperineal optical fibers inserted under trans-rectal ultrasound guidance under general anesthesia.
  
  
  CONCLUSIONS
  Based on the experience gained through hundreds of procedures, we describe here the standardized technique of vascular-targeted photodynamic therapy with TOOKAD(®) Soluble defined during the phase II and III trials.
authors: Urology Department, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France, arazzouzi@chu-angers.fr.
authors: Abdel-Rahmene
authors: AR
authors: Azzouzi
authors: Souhil
authors: S
authors: Lebdai
authors: Fawzi
authors: F
authors: Benzaghou
authors: Christian
authors: C
authors: Stief
mesh_terms: D001429:Bacteriochlorophylls / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010778:Photochemotherapy / Q000379:methods* / Q000592:standards*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D001429:Bacteriochlorophylls; D017319:Photosensitizing Agents; C456120:palladium-bacteriopheophorbide