title: Prognostic evaluation of percentage variation of metabolic tumor burden calculated by dual-phase (18) FDG PET-CT imaging in patients with head and neck cancer.
abstract: The purpose of this study was to investigate the prognostic value of percentage variation of metabolic tumor burden in patients with head and neck squamous cell carcinoma (HNSCC).
  
  
  
  Patients referred to undergo (18) fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT for staging of HNSCC were included in this study. Using a dual-phase method, standardized uptake value maximum (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were recorded and respectively used to calculate retention index (RI), %ΔMTV, and %ΔTLG. Recurrence-free survival (RFS) was determined by Kaplan-Meier method and compared with studied PET parameters in univariate and multivariate.
  
  
  
  Seventy patients (61 men/9 women; 62.9 ± 9.1 years old) were included. In univariate, SUVmax, RI, MTV, and TLG (p ≤ .0001) were significantly correlated with RFS, unlike %ΔMTV (p = 137) and %ΔTLG (p = .517). In multivariate, RI (p = .005) and MTV (p = .022) persisted as independent prognostic factors.
  
  
  
  Our results did not prove a prognostic interest of percentage variation of metabolic tumor burden in patients with HNSCC but confirmed that RI and MTV are independently correlated with RFS. © 2015 Wiley Periodicals, Inc. Head Neck 38: E600-E606, 2016.
authors: Department of Nuclear Medicine, University Hospital of Brest, Brest, France.|European University of Brittany, EA3878 GETBO, IFR 148, Brest, France.
authors: Ronan
authors: R
authors: Abgral
authors: Department of Head and Neck Surgery, University Hospital of Brest, Brest, France.
authors: Gérald
authors: G
authors: Valette
authors: Department of Nuclear Medicine, University Hospital of Brest, Brest, France.
authors: Philippe
authors: P
authors: Robin
authors: Department of Radiology, Military Hospital of Brest, Brest, France.
authors: Jean
authors: J
authors: Rousset
authors: Department of Nuclear Medicine, University Hospital of Brest, Brest, France.
authors: Nathalie
authors: N
authors: Keromnes
authors: Department of Nuclear Medicine, University Hospital of Brest, Brest, France.|European University of Brittany, EA3878 GETBO, IFR 148, Brest, France.
authors: Pierre-Yves
authors: PY
authors: Le Roux
authors: Department of Head and Neck Surgery, University Hospital of Brest, Brest, France.
authors: Rémi
authors: R
authors: Marianowski
authors: Department of Nuclear Medicine, University Hospital of Brest, Brest, France.|European University of Brittany, EA3878 GETBO, IFR 148, Brest, France.
authors: Pierre-Yves
authors: PY
authors: Salaün
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: dual-phase positron emission tomography (PET) imaging; head and neck squamous cell carcinoma; metabolic tumor burden; recurrence-free survival