title: Beneficial Effects of Renal Denervation on Pulmonary Vascular Remodeling in Experimental Pulmonary Artery Hypertension.
abstract: OBJECTIVE
  Activation of both the sympathetic nervous system and the renin-angiotensin-aldosterone system is closely associated with pulmonary arterial hypertension. We hypothesized that renal denervation decreases renin-angiotensin-aldosterone activity and inhibits the progression of pulmonary arterial hypertension.
  
  
  METHODS
  Twenty-two beagles were randomized into 3 groups. The dogs' pulmonary dynamics were measured before and 8 weeks after injection of 0.1mL/kg dimethylformamide (control dogs) or 2mg/kg dehydromonocrotaline (pulmonary arterial hypertension and pulmonary arterial hypertension + renal denervation dogs). Eight weeks after injection, neurohormone levels and pulmonary tissue morphology were measured.
  
  
  RESULTS
  Levels of plasma angiotensin II and endothelin-1 were significantly increased after 8 weeks in the pulmonary arterial hypertension dogs and were higher in the lung tissues of these dogs than in those of the control and renal denervation dogs (mean [standard deviation] angiotensin II: 65 [9.8] vs 38 [6.7], 46 [8.1]; endothelin-1: 96 [10.3] vs 54 [6.2], 67 [9.4]; P < .01). Dehydromonocrotaline increased the mean pulmonary arterial pressure (16 [3.4] mmHg vs 33 [7.3] mmHg; P < .01), and renal denervation prevented this increase. Pulmonary smooth muscle cell proliferation was higher in the pulmonary arterial hypertension dogs than in the control and pulmonary arterial hypertension + renal denervation dogs.
  
  
  CONCLUSIONS
  Renal denervation attenuates pulmonary vascular remodeling and decreases pulmonary arterial pressure in experimental pulmonary arterial hypertension. The effect of renal denervation may contribute to decreased neurohormone levels.
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Zhao
authors: Z
authors: Qingyan
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Jiang
authors: J
authors: Xuejun
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Tang
authors: T
authors: Yanhong
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Dai
authors: D
authors: Zixuan
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Wang
authors: W
authors: Xiaozhan
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Wang
authors: W
authors: Xule
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Guo
authors: G
authors: Zongwen
authors: Department of Ultrasonography, Renmin Hospital of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Hu
authors: H
authors: Wei
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China.
authors: Yu
authors: Y
authors: Shengbo
authors: Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Wuchang, Wuhan City, People's Republic of China. Electronic address: huangcongxin@vip.163.com.
authors: Huang
authors: H
authors: Congxin
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D003094:Collagen / Q000378:metabolism; D004126:Dimethylformamide / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D004285:Dogs; D004452:Echocardiography; D004562:Electrocardiography; D019332:Endothelin-1 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006352:Heart Ventricles / Q000378:metabolism; D006439:Hemodynamics / Q000502:physiology; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D007668:Kidney / Q000294:innervation; D008168:Lung / Q000378:metabolism; D008297:Male; D016686:Monocrotaline / Q000031:analogs & derivatives / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism; D011897:Random Allocation; D012077:Renal Artery / Q000601:surgery*; D012084:Renin-Angiotensin System / Q000502:physiology; D013562:Sympathectomy / Q000379:methods*; D066253:Vascular Remodeling / Q000502:physiology
chemical_list: D019332:Endothelin-1; D018377:Neurotransmitter Agents; D000804:Angiotensin II; C014114:monocrotaline pyrrole; D016686:Monocrotaline; D004126:Dimethylformamide; D003094:Collagen; D015232:Dinoprostone
keywords: Ablación; Ablation; Angiotensin II; Angiotensina II; Endotelina; Endothelin; Hipertensión arterial pulmonar; Inervación simpática renal; Pulmonary arterial hypertension; Renal sympathetic nerve