title: Synthesis of conjugated bile acids/azastilbenes as potential antioxidant and photoprotective agents.
abstract: A series of 14 bile acids/azastilbenes conjugates (1a-g and 2a-g) was prepared through the condensation of bile amides (1 and 2) and aromatic aldehydes. The newly synthesized conjugates were evaluated in vitro for their antioxidant and photoprotective activities. Six compounds (1, 1a, 1b, 2, 2a and 2b) showed promising antioxidant activity with IC50 values of 19.60-31.83 μg mL(-1). The synthesized compounds presented a varied photoprotection profile, with the SPF ranging from 2 to 9. Among the 16 compounds tested for the protection against UVB sunrays, 3 compounds (2c, 2e and 2g) presented more significant protection than resveratrol and the free azastilbene 3; while the UVAPF increased from 2 in resveratrol and 5 in 3 to 5-11 in the majority of the conjugates.
authors: Departamento de Química, Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora 36036-900, Brazil. Electronic address: julianalves07@yahoo.com.br.
authors: Juliana Alves
authors: JA
authors: dos Santos
authors: NUPICS Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil; Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, SC 88040-090, Brazil.
authors: Hudson Caetano
authors: HC
authors: Polonini
authors: NUPICS Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil.
authors: Érika Yoko
authors: ÉY
authors: Suzuki
authors: NUPICS Núcleo de Pesquisa e Inovação em Ciências da Saúde, Universidade Federal de Juiz de Fora, Juiz de Fora, MG 36036-900, Brazil.
authors: Nádia R B
authors: NR
authors: Raposo
authors: Departamento de Química, Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora 36036-900, Brazil.
authors: Adilson David
authors: AD
authors: da Silva
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry; D001372:Aza Compounds; D001647:Bile Acids and Salts / Q000138:chemical synthesis / Q000737:chemistry; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry; D013473:Sunscreening Agents / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001372:Aza Compounds; D001647:Bile Acids and Salts; D013267:Stilbenes; D013473:Sunscreening Agents
keywords: Antioxidant activity; Azastilbenes; Bile acids; Photoprotective activity; Schiff bases