title: [Occupational semicircular lipoatrophy associated with serum adipokine abnormalities].
abstract: OBJECTIVE
  The aim of this study was to examine the relationship between semicircular lipoatrophy (SL), inflammation marker (high sensibility C-reactive protein [hs-CRP]), adipokines (leptine, chemerine and vaspine) and autoimmune markers (rheumatoid factor [RF], C3 and C4 complement fractions, antinuclear antibodies [ANA], HLA DR3, and DR4). Chemerine is an adipokine, but also is an immunity marker.
  
  
  METHODS
  A case-control study was performed in May 2013; 21 cases were included. The closest healthy coworker to each case was used as a control. We calculated Kruskal-Wallis nonparametric test.
  
  
  RESULTS
  We found statistical significance (P<.05) between SL and raised hs-CRP, raised leptine and low chemerine.
  
  
  CONCLUSIONS
  i) There seems to be an underlying inflammatory component (raised hs-CRP) in SL; ii) adipokine alteration (raised leptine and low chemerine) supports the idea that adipocytic differentiation is affected in SL, and iii) we have not found any immune marker associated with SL, except chemerine itself, which could explain a possible association between SL and immunity.
authors: Medicina del Trabajo, Servicio de Prevención de Riesgos Laborales, Grupo Banco Popular (GBP), Madrid, España; Departamento de Ciencias Morfológicas y Biomedicina, Facultad de Ciencias de la Salud, Universidad Europea de Madrid (UEM), Villaviciosa de Odón, Madrid, España. Electronic address: lreinoso@bancopopular.es.
authors: Luis
authors: L
authors: Reinoso-Barbero
authors: Medicina del Trabajo, Servicio de Prevención de Riesgos Laborales, Grupo Banco Popular (GBP), Madrid, España.
authors: Ramón
authors: R
authors: Díaz-Garrido
authors: Salud Laboral, Consejería de Sanidad, Comunidad de Madrid, Madrid, España.
authors: María-Fernanda
authors: MF
authors: González-Gómez
authors: Departamento de Matemática Aplicada y Estadística, Escuela Técnica Superior de Ingenieros Aeronáuticos, Universidad Politécnica de Madrid (UPM), Madrid, España.
authors: José
authors: J
authors: Olarrea
authors: Departamento de Ciencias Morfológicas y Biomedicina, Facultad de Ciencias de la Salud, Universidad Europea de Madrid (UEM), Villaviciosa de Odón, Madrid, España.
authors: Félix
authors: F
authors: Gómez-Gallego
authors: Departamento de Toxicología y Legislación Sanitaria, Facultad de Medicina, Universidad Complutense de Madrid (UCM), Madrid, España.
authors: Fernando
authors: F
authors: Bandrés
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008060:Lipodystrophy / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D009934:Organization and Administration
chemical_list: D054392:Adipokines; D015415:Biomarkers
keywords: Adipocinas y electrosensibilidad; Adipocytic differentiation; Adipokines and electrohypersensitivity; Diferenciación adipocítica; Lipoatrofia semicircular; Semicircular lipoatrophy