title: The effect of simvastatin treatment on bone repair of femoral fracture in animal model.
abstract: The aim of this research was to evaluate the fracture healing area in osteoporotic femur of female rats restrained by stainless steel wire by statin administration in two different doses (5 mg and 20 mg). Ninety female rats were divided into six groups (n = 15): SH, SH-5 mg, SH-20 mg, OVX, OVX-5 mg, and OVX-20 mg. The surgery consisted of the fracture of the left femur bone and stabilization by K-wire and the administration was restricted and weekly controlled in the drinking water. The euthanasia was conducted at three different moments, five animals per period: 7 d, 14 d, and 28 d. Densitometry, zymography, and histological analyses showed a significant difference between some groups. According to these findings, simvastatin promoted a positive action for bone repair, especially in the osteometabolic group treated with 20 mg of the drug.
authors: School of Dentistry of Ribeirao Preto, University of Sao Paulo , Ribeirao Preto, Sao Paulo , Brazil and.
authors: João Paulo Mardegan
authors: JP
authors: Issa
authors: Conrado
authors: C
authors: Ingraci de Lucia
authors: Bruna Gabriela
authors: BG
authors: Dos Santos Kotake
authors: Miliane
authors: M
authors: Gonçalves Gonzaga
authors: Fellipe Augusto
authors: FA
authors: Tocchini de Figueiredo
authors: Daniela
authors: D
authors: Mizusaki Iyomasa
authors: Ana Paula
authors: AP
authors: Macedo
authors: Edilson
authors: E
authors: Ervolino
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D004195:Disease Models, Animal; D005260:Female; D005264:Femoral Fractures / Q000188:drug therapy*; D017102:Fracture Healing / Q000187:drug effects; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage; D006937:Hypercholesterolemia / Q000188:drug therapy; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D010024:Osteoporosis / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000008:administration & dosage*; D013193:Stainless Steel
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013193:Stainless Steel; D019821:Simvastatin; D020778:Matrix Metalloproteinase 2; C522363:Mmp2 protein, rat; D020780:Matrix Metalloproteinase 9; C572337:Mmp9 protein, rat
keywords: Fracture healing; MMP and ovariectomy; simvastatin; statins