title: Mechanisms of epithelial wound detection.
abstract: Efficient wound healing requires the coordinated responses of various cell types within an injured tissue. To react to the presence of a wound, cells have to first detect it. Judging from their initial biochemical and morphological responses, many cells including leukocytes, epithelial cells, and endothelial cells detect wounds from over hundreds of micrometers within seconds-to-minutes. Wound detection involves the conversion of an injury-induced homeostatic perturbation, such as cell lysis, an unconstrained epithelial edge, or permeability barrier breakdown, into a chemical or physical signal. The signal is spatially propagated through the tissue to synchronize protective responses of cells near the wound site and at a distance. This review summarizes the triggers and mechanisms of wound detection in animals.
authors: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors: Balázs
authors: B
authors: Enyedi
authors: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: niethamp@mskcc.org.
authors: Philipp
authors: P
authors: Niethammer
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D016923:Cell Death; D002633:Chemotaxis; D042783:Endothelial Cells / Q000166:cytology* / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology* / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000502:physiology; D017382:Reactive Oxygen Species; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species; D002118:Calcium