title: Correlation between P2X7 receptor gene polymorphisms and gout.
abstract: Not all patients with hyperuricemia will develop acute gouty arthritis, indicating that other initiating factors need to be considered. The P2X7 receptor is an adenosine triphosphate-gated nonselective cation channel that has also been suggested to be a proinflammatory receptor. In the immune system, the P2X7 receptor is involved in the processing and release of various proinflammatory cytokines, including interleukin-1β (IL-1β), IL-18 and tumor necrosis factor-α (TNF-α). IL-1β is a central cytokine in the initiation of the acute inflammatory response, which plays a key role in the pathogenesis of gout and the pathology of acute gouty arthritis. This review will explore single-nucleotide polymorphisms in the P2X7R gene [including rs1718119 (Ala348Thr), rs208294 (His155Tyr), rs3751143 (Glu496Ala), rs28360457 (Arg307Gln) and rs2230911 (Thr357Ser)] and their correlation with the incidence of gout. We conclude that P2X7R gene polymorphisms impact the secretion of IL-1β and thus play a vital role in the pathogenesis of gout.
authors: Department of Rheumatology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, China.
authors: Qiong-Yao
authors: QY
authors: Gong
authors: Yong
authors: Y
authors: Chen
mesh_terms: D015210:Arthritis, Gouty / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006073:Gout / Q000235:genetics / Q000276:immunology; D006801:Humans; D033461:Hyperuricemia / Q000235:genetics* / Q000276:immunology; D053583:Interleukin-1beta / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D058486:Receptors, Purinergic P2X7 / Q000235:genetics* / Q000276:immunology
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; C546468:P2RX7 protein, human; D058486:Receptors, Purinergic P2X7