title: Plasma metabolomics reveals a potential panel of biomarkers for early diagnosis in acute coronary syndrome.
abstract: Discovery of new biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Recent advances in metabolomic technologies have drastically enhanced the possibility of improving the knowledge of its physiopathology through the identification of the altered metabolic pathways. In this study, analyses of peripheral plasma from non-ST segment elevation ACS patients and healthy controls by gas chromatography-mass spectrometry (GC-MC) permitted the identification of 15 metabolites with statistical differences (p< 0.05) between experimental groups. Additionally, validation by GC-MC and liquid chromatography-MC permitted us to identify a potential panel of biomarkers formed by 5-OH-tryptophan, 2-OH-butyric acid and 3-OH-butyric acid. This panel of biomarkers reflects the oxidative stress and the hypoxic state that suffers the myocardial cells and consequently constitutes a metabolomic signature of the atherogenesis process that could be used for early diagnosis of ACS.
authors: Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain.
authors: Carlos M
authors: CM
authors: Laborde
authors: Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain.
authors: Laura
authors: L
authors: Mourino-Alvarez
authors: Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
authors: María
authors: M
authors: Posada-Ayala
authors: Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
authors: Gloria
authors: G
authors: Alvarez-Llamas
authors: Department of Biochemistry, Hospital Virgen de la Salud, SESCAM, Toledo, Spain.
authors: Manuel Gómez
authors: MG
authors: Serranillos-Reus
authors: Department of Hemodynamic, Hospital Virgen de la Salud, SESCAM, Toledo, Spain.
authors: José
authors: J
authors: Moreu
authors: Department of Immunology, IIS-Fundación Jiménez Díaz, Madrid, Spain.|Department of Biochemistry and Molecular Biology I, Facultad de Biología, UCM, Madrid, Spain.
authors: Fernando
authors: F
authors: Vivanco
authors: Department of Cardiology, Hospital Virgen de la Salud, SESCAM, Toledo, Spain.
authors: Luis R
authors: LR
authors: Padial
authors: Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain.|Proteomic Unit, Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain.
authors: María G
authors: MG
authors: Barderas
keywords: Acute coronary syndrome; Biomarker; Metabolite; Metabolomics