title: Exploring hydrogen peroxide responsive thiazolidinone-based prodrugs.
abstract: A novel approach for developing prodrugs based on masked carboxylic acids is described. Rather than using conventional esterase-based activation, thiazolidinone protecting groups have been identified that can reveal carboxylic acid groups upon activation by hydrogen peroxide. This may prove valuable in the continuing development of prodrug strategies that rely on reactive oxygen species (ROS) as a trigger.
authors: Department of Chemistry & Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. scohen@ucsd.edu.
authors: Christian
authors: C
authors: Perez
authors: Jean-Philippe
authors: JP
authors: Monserrat
authors: Yao
authors: Y
authors: Chen
authors: Seth M
authors: SM
authors: Cohen
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism; D053778:Thiazolidines / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D011355:Prodrugs; D053778:Thiazolidines; D006861:Hydrogen Peroxide