title: Venovenous haemodiafiltration for the management of dabigatran overdose in intensive care unit.
abstract: Dabigatran is a direct thrombin inhibitor indicated for thromboembolism prophylaxis in patients with non-valvular atrial fibrillation. The procedure to manage dabigatran-associated haemorrhages is not well formalized. Conventional haemodialysis has been evaluated with good results. Patients with dabigatran-associated bleeding may be unstable and convective techniques like venovenous haemodiafiltration (HDF) can be interesting. We report the case of a 74-year-old, critically ill patient with haemorrhagic shock and dabigatran overexposure due to acute kidney injury. He underwent HDF and dabigatran blood concentrations decreased from 325.3 ng/mL to 160.5 ng/mL. We report here key pharmacokinetics parameters (half-life, extraction coefficient, clearance).
authors: Department of Nephrology , University Hospital of Saint Etienne , Saint Priest En Jarez , France.
authors: Guillaume
authors: G
authors: Claisse
authors: Department of Pharmacology , University Hospital of Saint Etienne , Saint Priest en Jarez , France.
authors: Xavier
authors: X
authors: Delavenne
authors: Department of Nephrology , University Hospital of Saint Etienne , Saint Priest En Jarez , France.
authors: Ingrid
authors: I
authors: Masson
authors: Department of Nephrology , University Hospital of Saint Etienne , Saint Priest En Jarez , France.
authors: Nicolas
authors: N
authors: Maillard
authors: Department of Nephrology , University Hospital of Saint Etienne , Saint Priest En Jarez , France.
authors: Eric
authors: E
authors: Alamartine
authors: Department of Nephrology , University Hospital of Saint Etienne , Saint Priest En Jarez , France.
authors: Christophe
authors: C
authors: Mariat
keywords: dabigatran overexposure; haemodiafiltration; haemorrhagic shock; intensive care