title: Texture Analysis of Non-Contrast-Enhanced Computed Tomography for Assessing Angiogenesis and Survival of Soft Tissue Sarcoma.
abstract: OBJECTIVE
  To evaluate the role of computed tomographic (CT) texture analysis in assessing tumor angiogenesis and survival of soft tissue sarcoma (STS).
  
  
  METHODS
  In 20 patients with STSs, tumor texture parameters, which were measured on pretherapeutic CT using CT texture analysis software with the spatial scale filter extracting fine to coarse texture, were compared with microvessel density, plasma vascular endothelial growth factor (VEGF), soluble VEGF receptor-1, and overall survival (OS).
  
  
  RESULTS
  Mean of positive pixels (MPP) showed a positive correlation with microvessel density (P = 0.02). Entropy at medium texture scales (spatial scale filter = 3, 4, 5) showed positive correlations with VEGF (P = 0.03, P = 0.009, and P = 0.02, respectively), and entropy without filtration showed a positive correlation with soluble VEGF receptor-1 (P = 0.02). In the univariate analysis, kurtosis at a medium texture scale and MPP showed significant correlations with OS (P = 0.04 and P = 0.007), and multivariate analysis demonstrated that MPP was an independent prognostic factor (P = 0.01).
  
  
  CONCLUSIONS
  Texture parameters are associated with tumor angiogenesis and OS in STS.
authors: From the *Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA; †Department of Radiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; ‡Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY; §Steele Laboratory, Massachusetts General Hospital, Boston, MA; and ∥Institute of Nuclear Medicine, University College London, UK.
authors: Koichi
authors: K
authors: Hayano
authors: Fang
authors: F
authors: Tian
authors: Avinash R
authors: AR
authors: Kambadakone
authors: Sam S
authors: SS
authors: Yoon
authors: Dan G
authors: DG
authors: Duda
authors: Balaji
authors: B
authors: Ganeshan
authors: Dushyant V
authors: DV
authors: Sahani
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D020360:Neoadjuvant Therapy; D009389:Neovascularization, Pathologic; D015588:Observer Variation; D012509:Sarcoma / Q000097:blood* / Q000000981:diagnostic imaging* / Q000628:therapy; D016019:Survival Analysis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A