title: Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection.
abstract: Chronic active Epstein-Barr virus (EBV) infection (CAEBV), characterized by persistent infectious mononucleosis-like symptoms, can lead to cardiovascular complications including coronary artery aneurysm or myocarditis. Here, we present the case of an 11-year-old boy with pulmonary arterial hypertension (PAH) and junctional ectopic tachycardia associated with CAEBV. The patient did not have any major symptoms attributed to CAEBV, such as fever, lymphadenopathy or splenomegaly when the PAH developed. Mild liver dysfunction was found at the first examination, and it persisted. Two years after the PAH symptoms appeared, CAEBV was evident, based on deteriorated liver function, hepatosplenomegaly, and coronary artery aneurysms. CAEBV should be considered as a cause of secondary PAH, particularly when liver dysfunction coexists.
authors: Department of Pediatrics, Takeda General Hospital, Fukushima, Japan.
authors: Yutaka
authors: Y
authors: Fukuda
authors: Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
authors: Nobuo
authors: N
authors: Momoi
authors: Department of Pediatrics, Takeda General Hospital, Fukushima, Japan.
authors: Mitsuko
authors: M
authors: Akaihata
authors: Department of Pediatrics, Takeda General Hospital, Fukushima, Japan.
authors: Katsutoshi
authors: K
authors: Nagasawa
authors: Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
authors: Masaki
authors: M
authors: Mitomo
authors: Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
authors: Yoshimichi
authors: Y
authors: Aoyagi
authors: Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
authors: Kisei
authors: K
authors: Endoh
authors: Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.
authors: Mitsuaki
authors: M
authors: Hosoya
mesh_terms: D002648:Child; D002908:Chronic Disease; D004452:Echocardiography; D004562:Electrocardiography; D020031:Epstein-Barr Virus Infections / Q000000981:diagnostic imaging / Q000821:virology*; D017809:Fatal Outcome; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000821:virology*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D013613:Tachycardia, Ectopic Junctional / Q000000981:diagnostic imaging / Q000821:virology*; D014184:Transplantation, Homologous
keywords: chronic active Epstein-Barr virus infection; coronary artery aneurysm; junctional ectopic tachycardia; pulmonary arterial hypertension