title: Effects of positive airway pressure therapy on exercise parameters in obstructive sleep apnea.
abstract: OBJECTIVE
  Obstructive sleep apnea (OSA) is common in adult population and may cause many adverse clinical results. We aimed to investigate possible changes in cardiopulmonary exercise capacity in OSA patients after positive airway pressure treatment.
  
  
  METHODS
  Patients who were admitted to Gaziantep University Pulmonary Diseases Sleep Center and diagnosed OSA were included. Studies carried out between May 2010 and July 2011. Sixty-five consecutive patients were included in this prospective study.
  
  
  METHODS
  Sixty-five adult sleep clinic patients diagnosed with OSA by polysomnography and in whom continuous positive airway pressure (CPAP) ventilation therapy was indicated were included. Cardiopulmonary exercise capacity was assessed by bicycle ergometry during diagnostic workup and at least 4 weeks later.
  
  
  RESULTS
  There were 57 (87.7%) males. The mean age was 45.29 (10.57) years, apnea-hypopnea index 38.02 (23.19 events/h, body mass index 31.72 (4.87) kg/m2. Patients were grouped with respect to compliance with CPAP. The peak oxygen consumption (VO2) did not change in the CPAP compliant group (n=33) (22.52 [6.62] mL/[min.kg] to 21.32 [5.26] mL/[min.kg]; P=.111), and decreased from 21.31 (5.66) mL/(min.kg) to 19.92 (5.40) mL/(min.kg) (P=.05) in the CPAP noncompliant group. Work rate increased from 84.0% to 85.0% in the CPAP compliant group and decreased from 79.6% to 77.1% in the noncompliant group (P=.041). In the group that used the device, ventilation (VE)/VCO2 at anaerobic threshold (AT) declined from 28.42 to 27.36; however, it increased from 27.41 to 27.81 in the group that did not use the device (P=.033).
  
  
  CONCLUSIONS
  Decline in the exercise capacity was prevented in patients with OSA after 4 weeks of CPAP therapy. The changes in VE/VCO2 at AT suggest the reversal of pathophysiologic changes in OSA with the CPAP therapy that may improve cardiac function and cause more efficient ventilation.
authors: Ilker
authors: I
authors: Ozsarac
authors: Nazan
authors: N
authors: Bayram
authors: Dr. Meral Uyar, Department of Pulmonary Medicine, Gaziantep University, Gaziantep 2700, Turkey, T: 90-342-3606060 (76183 ext.), F: 90-342-3606306, meraluyar1@yahoo.com.
authors: Meral
authors: M
authors: Uyar
authors: Deniz
authors: D
authors: Kosovali
authors: Nevhiz
authors: N
authors: Gundogdu
authors: Ayten
authors: A
authors: Filiz
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold; D045422:Continuous Positive Airway Pressure; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011446:Prospective Studies; D012123:Pulmonary Ventilation; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000628:therapy*