title: Protective Effect of 10-Hz, 1-mT Electromagnetic Field Exposure Against Hypoxia/Reoxygenation Injury in HK-2 Cells.
abstract: We investigated the protective effects of electromagnetic field (EMF) on the survival of the human renal proximal tubular cell line, HK-2, using an in vitro hypoxia/reoxygenation (H/R) injury model. The survival rate of cells cultured under H/R condition declined significantly, while the intracellular reactive oxygen species (ROS) levels markedly increased. The 10 Hz/1 mT EMF exposure reversed the H/R induced reduction in cell survival and induction of intracellular ROS. Our results suggest that 10 Hz/1 mT EMF exposure could inhibit H/R-induced cell death of HK-2 via suppression of intracellular ROS production and that this treatment might be clinically useful for the amelioration of renal ischemia/reperfusion injury.
authors: Department of Biological Science, Gachon University, Incheon, 406-799, Korea.
authors: Soonho
authors: S
authors: Lim
authors: Department of Electrical and Electronic Engineering, Hankyong National University, Anseong-si, Kyonggi-do 456-749, Korea.
authors: Soo-Chan
authors: SC
authors: Kim
authors: Department of Biological Science, Gachon University, Incheon, 406-799, Korea.
authors: Jae Young
authors: JY
authors: Kim
mesh_terms: D015687:Cell Hypoxia; D002460:Cell Line; D004574:Electromagnetic Fields; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000378:metabolism / Q000528:radiation effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D017382:Reactive Oxygen Species