title: Are studies of motor cortex plasticity relevant in human patients with Parkinson's disease?
abstract: Over the last decade, electrophysiological studies in parkinsonian animals have shown that there are abnormalities of synaptic plasticity in motor areas of cortex and basal ganglia. In humans with Parkinson's disease (PD), cortical plasticity has been widely investigated using transcranial magnetic stimulation. A number of studies have reported abnormal responses to several different conditioning protocols, but their relationship to altered basal ganglia output and dopaminergic loss is still not entirely clear. Thus in the near future it seems unlikely that measures of cortical plasticity could be used as a biomarker of disease severity and progression. In this review we provide an overview on current knowledge of abnormalities of plasticity in PD in the light of recent advances in parkinsonian animal models. Finally we will discuss the relevance of abnormalities of plasticity in the clinical context of PD.
authors: Neuromed Institute (IRCCS), Pozzilli (IS), Italy.
authors: Matteo
authors: M
authors: Bologna
authors: Neuromed Institute (IRCCS), Pozzilli (IS), Italy.
authors: Antonio
authors: A
authors: Suppa
authors: Neuromed Institute (IRCCS), Pozzilli (IS), Italy.
authors: Antonella
authors: A
authors: Conte
authors: Department of Neurology and Psychiatry, Sapienza University of Rome, Italy.
authors: Anna
authors: A
authors: Latorre
authors: Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London, UK.
authors: John C
authors: JC
authors: Rothwell
authors: Neuromed Institute (IRCCS), Pozzilli (IS), Italy; Department of Neurology and Psychiatry, Sapienza University of Rome, Italy. Electronic address: alfredo.berardelli@uniroma1.it.
authors: Alfredo
authors: A
authors: Berardelli
mesh_terms: D000818:Animals; D019054:Evoked Potentials, Motor; D006801:Humans; D009044:Motor Cortex / Q000502:physiology* / Q000503:physiopathology; D009473:Neuronal Plasticity; D010300:Parkinson Disease / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation
keywords: Neurophysiology; Parkinson’s disease; Synaptic transmission and plasticity; Transcranial magnetic stimulation