title: Imaging mass spectrometry: enabling a new age of discovery in biology and medicine through molecular microscopy.
abstract: Imaging mass spectrometry (IMS) has become a valuable tool for the production of molecular maps in samples ranging from solid inorganic materials to biologicals such as cells and tissues. The unique features of IMS are its ability to map a wide variety of different types of molecules, its superb molecular specificity, and its potential for discovery since no target-specific reagents are needed. IMS has made significant contributions in biology and medicine and promises to be a next generation tool in anatomic pathology.
authors: Mass Spectrometry Research Center and Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA, r.caprioli@vanderbilt.edu.
authors: Richard M
authors: RM
authors: Caprioli
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D051379:Mice; D008853:Microscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods; D010336:Pathology / Q000379:methods; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods