title: Comparing the efficacy of intravenous acetaminophen and intravenous meperidine in pain relief after outpatient urological surgery.
abstract: BACKGROUND
  Pain relief after surgery is an essential component of postoperative care.
  
  
  OBJECTIVE
  The purpose of this study was to compare the efficacy of intravenous acetaminophen and intravenous meperidine in pain relief after outpatient urological surgery.
  
  
  METHODS
  In a prospective, randomized, double-blind clinical trial, 100 outpatients of urological surgery were studied in two groups of acetaminophen (A) and meperidine (M). Patients in group A received 1g of acetaminophen in 100 mL saline within 15 minutes and patients in group M received a single intravenous injection of meperidine 0.5 mg/kg, 15 minutes prior to the end of operation. Postoperative pain was recorded using visual analog scale (VAS). Vital signs, nausea, vomiting, dizziness and respiratory depressions were compared between the two groups.
  
  
  RESULTS
  Pain severity in patients treated with intravenous acetaminophen six hours after the operation within one-hour interval was significantly lower than meperidine group (P < 0.0001). Ninety patients in the meperidine group and five patients in the acetaminophen group required additional doses of analgesics. Nausea was significantly lower in acetaminophen group than meperidine group.
  
  
  CONCLUSIONS
  Intravenous acetaminophen reduced pain following outpatient urological surgery more significantly than meperidine.
authors: Department of Anesthesiology, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Khosro
authors: K
authors: Kolahdouzan
authors: Department of Anesthesiology, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mahmood
authors: M
authors: Eydi
authors: Department of Anesthesiology, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Hassan
authors: H
authors: Mohammadipour Anvari
authors: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Samad Ej
authors: SE
authors: Golzari
authors: Department of Anesthesiology, Faculty of Paramedical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Reyhaneh
authors: R
authors: Abri
authors: Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Morteza
authors: M
authors: Ghojazadeh
authors: Department of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Seyed Hossein
authors: SH
authors: Ojaghihaghighi
keywords: Acetaminophen; Meperidine; Outpatient Surgery; Postoperative Pain