title: Nutraceuticals and Blood Pressure Control: Results from Clinical Trials and Meta-Analyses.
abstract: Beyond the well-known effects on blood pressure (BP) of the dietary approaches to stop hypertension (DASH) and the Mediterranean diets, a large number of studies has investigated the possible BP lowering effect of different dietary supplements and nutraceuticals, the most part of them being antioxidant agents with a high tolerability and safety profile. In particular relatively large body of evidence support the use of potassium, L-arginine, vitamin C, cocoa flavonoids, beetroot juice, coenzyme Q10, controlled-release melatonin, and aged garlic extract. However there is a need for data about the long-term safety of a large part of the above discussed products. Moreover further clinical research is advisable to identify between the available active nutraceuticals those with the best cost-effectiveness and risk-benefit ratio for a large use in general population with low-added cardiovascular risk related to uncomplicated hypertension.
authors: Medical and Surgical Sciences Department, University of Bologna, Bologna, Italy, afgcicero@cardionet.it.
authors: Arrigo F G
authors: AF
authors: Cicero
authors: Alessandro
authors: A
authors: Colletti
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D027461:Beta vulgaris; D001794:Blood Pressure / Q000187:drug effects*; D002338:Carotenoids / Q000494:pharmacology; D002986:Clinical Trials as Topic; D019587:Dietary Supplements / Q000009:adverse effects; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D000067030:Fruit and Vegetable Juices; D005737:Garlic; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D000077276:Lycopene; D008274:Magnesium / Q000494:pharmacology; D008550:Melatonin / Q000494:pharmacology; D015201:Meta-Analysis as Topic; D008903:Minerals / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D019936:Probiotics / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D005231:Fatty Acids, Unsaturated; D005419:Flavonoids; D008903:Minerals; D010455:Peptides; D010936:Plant Extracts; D011506:Proteins; D013267:Stilbenes; D014815:Vitamins; D014451:Ubiquinone; D002338:Carotenoids; C024070:pycnogenols; C024989:coenzyme Q10; D008274:Magnesium; D008550:Melatonin; D000077185:Resveratrol; D011188:Potassium; D000077276:Lycopene