title: [Use of glutamine in total parenteral nutrition of bone marrow transplant patients].
abstract: Glutamine is an essential amino acid for nucleotide synthesis and an important energy resource for cellular division. There is contradictory evidence about its benefits as part of parenteral nutrition. More than 75% of bone marrow transplant patients (BMTP) have, during their evolution, digestive tract complications limiting enteral nutrition, for this reason, sometimes total parenteral nutrition (TPN) is required.
  
  
  OBJECTIVE
  Our aim was to analyze the relation between the use of glutamine in TPN of BMTP, and the evolution of clinical acute complications as mucositis, graft versus host disease (GVHD) and infections days of stay and days of TPN.
  
  
  METHODS
  observational retrospective study. All BMTP with total parenteral nutrition during the period 2007-2013 were included. We analyzed days of stay, days of nutrition, glutamine use and acute complications. Results were analyzed in SPSS 15.0.
  
  
  RESULTS
  73 BMTP were divided in two comparable groups depending on glutamine use. The mean age was 36,96 ± 12,89 years. 47,9% of patients received glutamine in TPN. Patients who received glutamine had a mean stay of 31,49±7,41 days with 14,11±5,87 days of TPN compared with the non-glutamine group with 32,16±7,99 and 15,50±7,71 days respectively (p=0,71 y 0,39). Mucositis lasted 12,23±5,66 days in the glutamine group, and 15,50±7,71 days in the non-glutamine group (p=0,042). Severe grades of GVHD (II,III) was observed in 20,6% of the non glutamine group compared with the 13,7% of the other group (p=0,636). In patients with glutamine suplementation, mucositis last 12,23±5,66 days compared with 15,50±7,71 days in the non-glutamine group (p=0,042).13,7% of all patients suffered infections while receiving TPN with glutamine compared with 16,4% in patients who did not receive glutamine (p=0,700).
  
  
  CONCLUSIONS
  In our group, a statistically significant reduction in the duration of mucositis was observed in patients who received parenteral glutamine.
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: Aura Dulcinea
authors: AD
authors: Herrera-Martínez
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. mralhambra@hotmail.com.
authors: María R
authors: MR
authors: Alhambra Expósito
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: Gregorio
authors: G
authors: Manzano García
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: María J
authors: MJ
authors: Molina Puertas
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: Alfonso
authors: A
authors: Calañas Continente
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: Rodrigo
authors: R
authors: Bahamondez Opazo
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: Concepción
authors: C
authors: Muñoz Jiménez
authors: UGC Hematología, Hospital Universitario Reina Sofía. España.. aurita.dhm@gmail.com.
authors: Rafael
authors: R
authors: Rojas Contreras
authors: UGC Endocrinología y Nutrición, Hospital Universitario Reina Sofía.. aurita.dhm@gmail.com.
authors: María A
authors: MA
authors: Gálvez Moreno
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D005973:Glutamine / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000379:methods*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D005973:Glutamine