title: Association of Angiotensin-Converting Enzyme ACE Gene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population.
abstract: OBJECTIVE
  The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with vitiligo in the Indians and Koreans, but not in those of English or Turkish background. We investigated the ACE (I/D) polymorphism in vitiligo patients for the first time in Egypt and compared serum ACE levels between vitiligo patients and controls. The present study was carried out in 100 vitiligo patients (40 males and 60 females) and in 100 healthy controls of an Egyptian population using the polymerase chain reaction genotyping method.
  
  
  RESULTS
  The ACE genotype and allele frequency was significantly different between vitiligo patients and controls. Our results revealed a significant increase in the frequency of the ACE I allele (p=0.002; odds ratio: 1.99; 95% confidence intervals: 1.207-3.284) with an overrepresentation of I/D genotype in the vitiligo patient group. Furthermore, there was a significant difference between the segmental, nonsegmental, and focal vitiligo in ACE gene genotype distribution. Serum ACE levels were significantly increased in vitiligo patients compared to controls (p=0.034).
  
  
  CONCLUSIONS
  This study suggests that, for the first time, ACE gene polymorphism confers susceptibility to vitiligo in the Egyptian population.
authors: 1 Department of Medical Biochemistry, Faculty of Medicine, Suez Canal University , Ismailia, Egypt .
authors: Dahlia I
authors: DI
authors: Badran
authors: Hesham
authors: H
authors: Nada
authors: Ranya
authors: R
authors: Hassan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004534:Egypt; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D014820:Vitiligo / Q000097:blood / Q000201:enzymology / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A