title: Comparison of antiresorptive effect of hormone therapy and ibandronate in postmenopausal osteoporotic women by assessing type I collagen C-telopeptide levels.
abstract: OBJECTIVE
  The aim of this study is to compare the antiresorptive effect of hormone therapy and oral ibandronate in postmenopausal osteoporotic women by measuring bone mineral density (BMD) and degradation products of C-terminal telopeptide of type I collagen (CTX) using serum crosslaps ELISA.
  
  
  METHODS
  The study is a randomized comparative trial.
  
  
  METHODS
  About 60 women with age > 40 years, having either surgical or medical menopause with T- or Z-score below -2.5 SD were included in the study. They were randomized into two groups of 30 each; one group received conventional hormone therapy (group I) and the other group received ibandronate monthly (group II). The treatment was given for 6 months.
  
  
  RESULTS
  The BMD increased from 0.894 g/cm(2) to 0.933 g/cm(2) (p < 0.01) in group I and from 0.865 g/cm(2) to 0.934 g/cm(2) (p < 0.01) in group II. The increase in BMD in group I (4.3%) was less than group II (7.9%) which was significant (p < 0.01). The serum CTX levels also showed significant reduction in both groups after 6 months of therapy; more reduction was seen in group II as compared to group I (41.5% vs. 4.6%, p < 0.01).
  
  
  CONCLUSIONS
  Ibandronate can be used as a substitute to hormone therapy in women presenting with osteoporosis. Long-term studies are needed to authenticate the observation.
authors: Department of Obstetrics and Gynaecology, University College of Medical Sciences & Guru Tegh Bahadur Hospital, New Delhi, India.
authors: N B
authors: NB
authors: Srividhya
authors: Department of Obstetrics and Gynaecology, University College of Medical Sciences & Guru Tegh Bahadur Hospital, New Delhi, India nilanchalisingh@gmail.com.
authors: Nilanchali
authors: N
authors: Singh
authors: Department of Obstetrics and Gynaecology, University College of Medical Sciences & Guru Tegh Bahadur Hospital, New Delhi, India.
authors: Neerja
authors: N
authors: Goel
authors: Department of Biochemistry, University College of Medical Sciences, New Delhi, India.
authors: J K
authors: JK
authors: Gambhir
authors: Department of Radiology, University College of Medical Sciences, New Delhi, India.
authors: Vinita
authors: V
authors: Rathi
authors: Department of Obstetrics and Gynaecology, University College of Medical Sciences & Guru Tegh Bahadur Hospital, New Delhi, India.
authors: Shalini
authors: S
authors: Rajaram
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D024042:Collagen Type I / Q000097:blood*; D004164:Diphosphonates / Q000008:administration & dosage*; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy / Q000379:methods*; D006801:Humans; D000077557:Ibandronic Acid; D007194:India; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000188:drug therapy*; D010455:Peptides / Q000097:blood*; D011446:Prospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D000077557:Ibandronic Acid
keywords: Collagen C-telopeptide levels; hormone therapy; ibandronate; osteoporosis; postmenopausal