title: A new utilization area for hyperbaric oxygen? Improving quality of stored blood.
abstract: OBJECTIVE
  Since blood bags have the ability for diffusion of gases, we investigated whether hyperbaric oxygen (HBO) exposure affects several vital parameters of stored blood.
  
  
  METHODS
  Bloods obtained from the same persons were used as both control and HBO groups and stored in pediatric bags with citrate-phosphate-dextrose solution. HBO administration was performed at 2.5 atm for 90 min, started 1 day after blood collection and repeated every 2 days for a total of 10 times. The study was terminated on the 21st day. Complete blood count, glucose, pH, and osmotic fragility values were measured every week.
  
  
  RESULTS
  Glucose and pH levels decreased in stored blood. In the HBO-exposed group, these decreases were less than in the control. In addition, mean corpuscular and platelet volumes tended to increase during storing process, but with HBO, these indexes remained lower, near physiologic levels. Another interesting finding of the study was the relative stable osmotic fragility ratio in the HBO group compared to the control blood.
  
  
  CONCLUSIONS
  HBO exposure has positive effects on pH, stability of erythrocytes, and energy source (glucose) of the medium. Thus, we concluded that HBO may be a useful application for life and quality of stored blood.
authors: Hakan
authors: H
authors: Ay
authors: Ramazan
authors: R
authors: Yüksel
authors: Kemal
authors: K
authors: Şimşek
authors: Turgut
authors: T
authors: Topal
authors: Özgur
authors: Ö
authors: Yeşilyurt
authors: Şükrü
authors: Ş
authors: Öter
authors: Ahmet
authors: A
authors: Korkmaz
authors: Mehmet
authors: M
authors: Özler
authors: Bülent
authors: B
authors: Uysal
authors: Halil
authors: H
authors: Yaman
authors: Orhan
authors: O
authors: Bedir
authors: Hayati
authors: H
authors: Bilgiç
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001793:Blood Preservation / Q000379:methods*; D001804:Blood Transfusion, Autologous; D002951:Citrates; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000737:chemistry / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005947:Glucose; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D002951:Citrates; C007077:citrate phosphate dextrose; D005947:Glucose; D010100:Oxygen