title: [Ambulatory arterial stiffness index and associated factors in patients with diabetic kidney disease].
abstract: OBJECTIVE
  To compare arterial stiffness between diabetic kidney disease and non-diabetic kidney diseaseand to identify factors predicting ambulatory arterial stiffness index (AASI).
  
  
  METHODS
  Forty-four patients with diabetic kidney disease (DKD group) and thirty-one patients with non-diabetic kidney disease (NDKD group) were recruited for this study. All of the participants had hypertension. The AASI (indirect reflex global arterial stiffness)and short-term blood pressure variability (BPV) were measured using a 24-h ambulatory BP monitoring, and compared.between DKD and NDKD groups using analyses of covariance, correlation analysis and multivariate linear regression model.
  
  
  RESULTS
  DKD patients had significantly higher levels of AASI than NDKD patients (0.55 +/- 0.14 vs. 0.45 +/- 0.16, P < 0.05). The 24-h systolic and daytime systolic BP variability of DKD patients was also higher than NDKD patients. In DKD patients, the correlation analysis revealed that the AASI showed association with 24-h systolic BP variability (24 hSBPV), 24-h diastolic BP variability (24 hDBPV),daytime diastolic BP variability (dDBPV), nighttime systolic BP variability (nSBPV) and nighttime diastolic BP variability (nDBPV), and nDBPV and age showed strong associations with AASI.
  
  
  CONCLUSIONS
  Although both DKD and NDKD patients suffered from arterial stiffness, greater AASI and short-term BPV was detected in DKD patients. AASI is associated with nDBPV and age. Optimal short-term BPV control in hypertensive type 2 diabetic patients with overt nephropathy may improve arterial elasticity.
authors: Li-jia
authors: LJ
authors: Chen
authors: Min
authors: M
authors: Wu
authors: Yan-huan
authors: YH
authors: Feng
authors: You-qun
authors: YQ
authors: Huang
authors: Li
authors: L
authors: Zang
authors: Ping
authors: P
authors: Fu
authors: Fang
authors: F
authors: Liu
mesh_terms: D001158:Arteries; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D003928:Diabetic Nephropathies / Q000473:pathology*; D004548:Elasticity; D006801:Humans; D006973:Hypertension; D007674:Kidney Diseases / Q000473:pathology; D016014:Linear Models; D059289:Vascular Stiffness