title: Chemopreventive potential of green tea catechins in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC), which is a common malignancy worldwide, usually develops in a cirrhotic liver due to hepatitis virus infection. Metabolic syndrome, which is frequently complicated by obesity and diabetes mellitus, is also a critical risk factor for liver carcinogenesis. Green tea catechins (GTCs) may possess potent anticancer and chemopreventive properties for a number of different malignancies, including liver cancer. Antioxidant and anti-inflammatory activities are key mechanisms through which GTCs prevent the development of neoplasms, and they also exert cancer chemopreventive effects by modulating several signaling transduction and metabolic pathways. Furthermore, GTCs are considered to be useful for the prevention of obesity- and metabolic syndrome-related carcinogenesis by improving metabolic disorders. Several interventional trials in humans have shown that GTCs may ameliorate metabolic abnormalities and prevent the development of precancerous lesions. The purpose of this article is to review the key mechanisms by which GTCs exert chemopreventive effects in liver carcinogenesis, focusing especially on their ability to inhibit receptor tyrosine kinases and improve metabolic abnormalities. We also review the evidence for GTCs acting to prevent metabolic syndrome-associated liver carcinogenesis.
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. shimim-gif@umin.ac.jp.
authors: Masahito
authors: M
authors: Shimizu
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. shirakamiyy@yahoo.co.jp.
authors: Yohei
authors: Y
authors: Shirakami
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. sakaih03@gifu-u.ac.jp.
authors: Hiroyasu
authors: H
authors: Sakai
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. kubota-gif@umin.ac.jp.
authors: Masaya
authors: M
authors: Kubota
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. kottii924@yahoo.co.jp.
authors: Takahiro
authors: T
authors: Kochi
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. taka.mailbox.789@gmail.com.
authors: Takayasu
authors: T
authors: Ideta
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. tsunemiyazaking@yahoo.co.jp.
authors: Tsuneyuki
authors: T
authors: Miyazaki
authors: Department of Medicine/Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. hmori@gifu-u.ac.jp.
authors: Hisataka
authors: H
authors: Moriwaki
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000517:prevention & control*; D002392:Catechin / Q000737:chemistry / Q000627:therapeutic use*; D018890:Chemoprevention; D002986:Clinical Trials as Topic; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000517:prevention & control*; D008659:Metabolic Diseases / Q000473:pathology / Q000517:prevention & control; D009765:Obesity / Q000473:pathology / Q000517:prevention & control; D013662:Tea / Q000737:chemistry / Q000378:metabolism
chemical_list: D013662:Tea; D002392:Catechin