title: Short-term comparison of accelerated and standard methods of corneal collagen crosslinking.
abstract: OBJECTIVE
  To compare the 6-month results of accelerated and standard collagen crosslinking (CXL) treatment of progressive keratoconus.
  
  
  METHODS
  Noor Eye Hospital, Tehran, Iran.
  
  
  METHODS
  Prospective randomized clinical trial.
  
  
  METHODS
  Two groups of eyes (intervention and control) received corneal collagen crosslinking (CXL) treatment. The intervention group received accelerated CXL (18 mW/cm(2), 5 minutes), and the control group received standard CXL (3 mW/cm(2), 30 minutes). The eyes were evaluated for changes in the visual indices, refraction, and topography preoperatively and 1, 3, and 6 months postoperatively and regarding corneal rigidity indices and the endothelial cell count (ECC) preoperatively and at 6 months.
  
  
  RESULTS
  The study evaluated 62 eyes (31 patient) in 2 groups. The mean changes in uncorrected (P = .733) and corrected (P = .646) distance visual acuities and manifest refraction spherical equivalent (P = .598) did not differ statistically significantly between the 2 groups. The central corneal thickness was higher in the standard group than the accelerated group (P = .025). The mean decrease in the maximum keratometry (K) (P = .865) and mean K (P = .974) and the mean changes in the asphericity (P = .272) were not statistically significantly different between the 2 groups. The mean changes in corneal hysteresis (CH) (P = .548) and the corneal resistance factor (CRF) (P = 1.000), CH-CRF (P = .282), and the area under the peak 2 (P = .260) were similar in both groups. The mean decrease in the ECC was not statistically significantly different between the 2 groups (P = .218).
  
  
  CONCLUSIONS
  Based on 6-month results, accelerated and standard corneal CXL arrested the progression of keratoconus similarly.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran. Electronic address: hhashemi@norc.ac.ir.
authors: Hassan
authors: H
authors: Hashemi
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Akbar
authors: A
authors: Fotouhi
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Mohammad
authors: M
authors: Miraftab
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Hooman
authors: H
authors: Bahrmandy
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Mohammad Amin
authors: MA
authors: Seyedian
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Kazem
authors: K
authors: Amanzadeh
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Shahab
authors: S
authors: Heidarian
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Hamidreza
authors: H
authors: Nikbin
authors: From the Noor Ophthalmology Research Center (Hashemi, Miraftab, Bahrmandy, Seyedian, Amanzadeh, Heidarian, Nikbin), Noor Eye Hospital, the Department of Epidemiology and Biostatistics (Fotouhi), School of Public Health, Tehran University of Medical Sciences, and the Department of Epidemiology and Biostatistics (Asgari), School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors: Soheila
authors: S
authors: Asgari
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003319:Corneal Stroma / Q000378:metabolism*; D003432:Cross-Linking Reagents; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D012256:Riboflavin / Q000627:therapeutic use; D014466:Ultraviolet Rays; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
chemical_list: D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin