title: Diabetic pregnancy outcomes in mothers treated with basal insulin lispro protamine suspension or NPH insulin: a multicenter retrospective Italian study.
abstract: OBJECTIVE
  The aim of this study was to study the efficacy and safety of long-acting insulin analog insulin lispro protamine suspension (ILPS) in diabetic pregnant women.
  
  
  METHODS
  In a multicenter observational retrospective study, we evaluated pregnancy outcome in 119 women affected by type 1 diabetes and 814 with gestational diabetes (GDM) treated during pregnancy with ILPS, compared with a control group treated with neutral protamine hagedorn (NPH) insulin.
  
  
  RESULTS
  Among type 1 diabetic patients, fasting blood glucose at the end of pregnancy was significantly lower in ILPS-treated than in NPH-treated patients. HbA1c levels across pregnancy did not differ between groups. Caesarean section and preterm delivery rates were significantly lower in the ILPS-women. Fetal outcomes were similar in the ILPS and NPH groups. Among GDM women, fasting blood glucose at the end of pregnancy was significantly lower in ILPS-treated than in NPH-treated patients. Duration of gestation was significantly longer, caesarian section and preterm delivery rates were lower in the ILPS-treated group. In addition, there were significantly fewer babies with an excessive ponderal index or neonatal hypoglycemic episodes in the ILPS group than in the NPH group.
  
  
  CONCLUSIONS
  Association of ILPS with rapid-acting analogs in pregnancy is safe in terms of maternal and fetal outcomes.
authors: a DPT Medicina, Università di Padova , Padova , Italy .
authors: Maria Grazia
authors: MG
authors: Dalfrà
authors: a DPT Medicina, Università di Padova , Padova , Italy .
authors: Angela
authors: A
authors: Soldato
authors: b DPT Medicina, Università di Verona , Verona , Italy .
authors: Paolo
authors: P
authors: Moghetti
authors: c UO Diabetologia e Endocrinologia Azienda , ULSS 5 Veneto , Veneto , Italy .
authors: Simonetta
authors: S
authors: Lombardi
authors: d UO Diabetologia Azienda , ULSS 10 Veneto , San Donà di Piave , Italy .
authors: Carmela
authors: C
authors: Vinci
authors: e UO Diabetologia Azienda , ULSS13 Veneto , Dolo , Italy .
authors: Angela Pia
authors: AP
authors: De Cata
authors: f UO Diabetologia, Azienda Provincia Trento , Trento , Italy .
authors: Tiziana
authors: T
authors: Romanelli
authors: g UOC Diabetologia, Ospedale Niguarda Ca' Granda Milano , Milano , Italy .
authors: Matteo
authors: M
authors: Bonomo
authors: h DPT di Medicina Clinica e Sperimentale, Università di Catania , Catania , Italy , and.
authors: Laura
authors: L
authors: Sciacca
authors: h DPT di Medicina Clinica e Sperimentale, Università di Catania , Catania , Italy , and.
authors: Federica
authors: F
authors: Tata
authors: i DPT di Scienze Farmaceutiche, Università di Padova , Padova , Italy.
authors: Eugenio
authors: E
authors: Ragazzi
authors: a DPT Medicina, Università di Padova , Padova , Italy .
authors: Alessio
authors: A
authors: Filippi
authors: a DPT Medicina, Università di Padova , Padova , Italy .
authors: Silvia
authors: S
authors: Burlina
authors: a DPT Medicina, Università di Padova , Padova , Italy .
authors: Annunziata
authors: A
authors: Lapolla
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D061268:Insulin Lispro / Q000627:therapeutic use*; D007336:Insulin, Isophane / Q000627:therapeutic use*; D007558:Italy / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011254:Pregnancy in Diabetics / Q000188:drug therapy* / Q000453:epidemiology; D012189:Retrospective Studies
chemical_list: D061268:Insulin Lispro; D007336:Insulin, Isophane
keywords: Diabetes; insulin therapy; pregnancy