title: Protracted arthritis in a Japanese patient with familial Mediterranean fever.
abstract: The most common arthritic involvement in familial Mediterranean fever (FMF) is acute self- limiting monoarthritis which typically lasts for 72 h. Hip joint involvement is uncommon in FMF and can result either from a process specific to this disease or from a coexisting inflammatory joint disease. We describe a 37-year-old woman with FMF and right osteoarthritis secondary to congenital hip dislocation. Periodic fever with right coxalgia lasting for 6 months was treated using colchicine. Genetic analysis revealed homozygous mutation in the MEFV gene (L110P-E148Q/L110P-E148Q), confirming the FMF diagnosis. Although the clinical presentation and course of FMF arthritis are diverse, delineating these clinical patterns may help with early recognition and treatment to prevent destructive arthritis in FMF. Clinicians should consider the possibility of FMF development in unusual monoarthritis patients with recurrent febrile attacks.
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Kiyoshi
authors: K
authors: Migita
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Sachi
authors: S
authors: Hisanaga
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Yasumori
authors: Y
authors: Izumi
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Chieko
authors: C
authors: Kawahara
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Yoshika
authors: Y
authors: Shigemitsu
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Nozomi
authors: N
authors: Iwanaga
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Toshitaka
authors: T
authors: Araki
authors: a Departments of General Internal Medicine and Rheumatology , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Masatsugu
authors: M
authors: Kamata
authors: b Department of Orthopedic surgery , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Masahiro
authors: M
authors: Izumi
authors: b Department of Orthopedic surgery , Nagasaki medical Center , Omura City, Nagasaki , Japan.
authors: Kenji
authors: K
authors: Kumagai
authors: c Department of Rheumatology , Nagasaki University Hospital , Sakamoto, Nagasaki , Japan.
authors: Atsushi
authors: A
authors: Kawakami
mesh_terms: D000328:Adult; D003078:Colchicine / Q000627:therapeutic use; D042241:Early Diagnosis; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006618:Hip Dislocation, Congenital / Q000150:complications; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007564:Japan; D009154:Mutation; D015207:Osteoarthritis, Hip / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D000071198:Pyrin / Q000235:genetics; D050257:Tubulin Modulators / Q000627:therapeutic use
chemical_list: C000604192:MEFV protein, human; D000071198:Pyrin; D050257:Tubulin Modulators; D003078:Colchicine
keywords: Colchicine; Congenital hip dislocation; Familial Mediterranean fever; MEFV gene