title: ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.
abstract: Uric acid (urate) has been suggested to play a protective role in Parkinson's disease onset through its antioxidant activity. Dysfunction of ABCG2, a high-capacity urate exporter, is a major cause for early-onset gout based on hyperuricemia. In this study, the effects of a dysfunctional ABCG2 variant (Q141K, rs2231142) were analyzed on the ages at onset of gout patients (N = 507) and Parkinson's disease patients (N = 1015). The Q141K variant hastened the gout onset (P = 0.0027), but significantly associated with later Parkinson's disease onset (P = 0.025). Our findings will be helpful for development of more effective prevention of Parkinson's disease.
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Hirotaka
authors: H
authors: Matsuo
authors: Department of Neurology, Juntendo University School of Medicine Tokyo, Japan.
authors: Hiroyuki
authors: H
authors: Tomiyama
authors: Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine Kobe, Japan.
authors: Wataru
authors: W
authors: Satake
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Toshinori
authors: T
authors: Chiba
authors: Department of Internal Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Hiroyuki
authors: H
authors: Onoue
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Yusuke
authors: Y
authors: Kawamura
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Akiyoshi
authors: A
authors: Nakayama
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Seiko
authors: S
authors: Shimizu
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Masayuki
authors: M
authors: Sakiyama
authors: Department of Neurology, Juntendo University School of Medicine Tokyo, Japan.
authors: Manabu
authors: M
authors: Funayama
authors: Department of Neurology, Juntendo University School of Medicine Tokyo, Japan.
authors: Kenya
authors: K
authors: Nishioka
authors: Midorigaoka Hospital Osaka, Japan.
authors: Toru
authors: T
authors: Shimizu
authors: Department of Internal Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Kenichi
authors: K
authors: Kaida
authors: Department of Internal Medicine, National Defense Medical College Tokorozawa, Japan ; Department of Physical Therapy, School of Health Sciences, Tokyo University of Technology Tokyo, Japan.
authors: Keiko
authors: K
authors: Kamakura
authors: Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine Kobe, Japan.
authors: Tatsushi
authors: T
authors: Toda
authors: Department of Neurology, Juntendo University School of Medicine Tokyo, Japan.
authors: Nobutaka
authors: N
authors: Hattori
authors: Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College Tokorozawa, Japan.
authors: Nariyoshi
authors: N
authors: Shinomiya