title: Femoral perfusion after pulsed electromagnetic field stimulation in a steroid-induced osteonecrosis model.
abstract: This study was designed to evaluate femoral perfusion after pulsed electromagnetic field (PEMF) stimulation in a steroid-induced osteonecrosis rabbit model by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Steroid-induced osteonecrosis was produced by single intramuscular injection of methylprednisolone in 15 rabbits. Eight rabbits underwent PEMF stimulation (PEMF group) and seven did not (control group). DCE-MRI was performed before PEMF stimulation, immediately before steroid administration, and 1, 5, 10, and 14 days after steroid administration. Regions of interest were set in the bilateral proximal femora. Enhancement ratio (ER), initial slope (IS), and area under the curve (AUC) were analyzed. ER, IS, and AUC in the control group significantly decreased after steroid administration compared with before administration (P<0.05). In PEMF group, IS significantly decreased; however, ER and AUC showed no significant differences after steroid administration compared with before. ER and IS in PEMF group were higher than in control group until 10th day, and AUC was higher until 5th day after steroid administration (P<0.05). PEMF stimulation restrains the decrease in blood flow after steroid administration.
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Akira
authors: A
authors: Ikegami
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Keiichiro
authors: K
authors: Ueshima
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Masazumi
authors: M
authors: Saito
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Kazuya
authors: K
authors: Ikoma
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Mikihiro
authors: M
authors: Fujioka
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Shigeki
authors: S
authors: Hayashi
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Masashi
authors: M
authors: Ishida
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Hiroyoshi
authors: H
authors: Fujiwara
authors: Department of Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Osam
authors: O
authors: Mazda
authors: Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors: Toshikazu
authors: T
authors: Kubo
mesh_terms: D000818:Animals; D019540:Area Under Curve; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy / Q000379:methods*; D005269:Femur / Q000098:blood supply* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone; D010020:Osteonecrosis / Q000503:physiopathology* / Q000628:therapy*; D011817:Rabbits; D012039:Regional Blood Flow; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D008775:Methylprednisolone
keywords: corticosteroid-induced osteonecrosis; dynamic contrast-enhanced MR; femoral blood flow