title: Oxidative damage markers are significantly associated with the carotid artery intima-media thickness after controlling for conventional risk factors of atherosclerosis in men.
abstract: BACKGROUND
  This study aimed to assess the association between oxidative damage markers and carotid artery intima-media thickness (CIMT) after controlling for conventional risk factors of atherosclerosis in multiple logistic regression models.
  
  
  RESULTS
  Fifty-one case male participants (CIMT ≥ 0.9 mm) were enrolled during their visits to Korean Genomic Rural Cohort Study of Wonju centers between May 1 and August 31, 2011, along with 51 control participants (CIMT < 0.9 mm) selected using frequency matching by age group. The levels of oxidative damage markers, 8-hydroxy-2'-deoxyquuanosine (8-OHdG), malondialdehyde (MDA), and 8-iso-prostaglandin F2α (Isoprostane), were measured. Conditional logistic regression models were used to evaluate relative relationships between the oxidative damage markers and the risk of high CIMT.
  
  
  RESULTS
  The markers of oxidative lipid (Isoprostane and MDA) and DNA (8-OHdG) damage were associated with CIMT after controlling for the conventional risk factors, including age, low density lipoprotein, body mass index, smoking history, alcohol consumption, and metabolic syndrome (ORs [95% CI] for Isoprostane: 3rd tertile, 8.47 [2.59-27.67]; for MDA: 3rd tertile, 8.47 [2.59-27.67]; for 8-OHdG: 3rd tertile, 5.58 [1.79-17.33]). When all the oxidative damage markers were incorporated in the same logistic regression model, only Isoprostane was significantly related to CIMT (OR [95% CI]: 4.22 [1.31-13.53] in 2nd tertile and 14.21 [3.34-60.56] in 3rd tertile).
  
  
  CONCLUSIONS
  In this nested case-control study, the oxidative damage markers of lipid and DNA were associated with CIMT even after controlling for the conventional risk factors of cardiovascular diseases.
authors: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea; The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea.
authors: Jin-Ha
authors: JH
authors: Yoon
authors: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors: Jang-Young
authors: JY
authors: Kim
authors: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea; Institute of Genomic Cohort, Yonsei University, Wonju, Korea.
authors: Jong-Ku
authors: JK
authors: Park
authors: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea; Institute of Genomic Cohort, Yonsei University, Wonju, Korea.
authors: Sang-Baek
authors: SB
authors: Ko
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D015331:Cohort Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D006801:Humans; D028421:Isoprostanes / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D028421:Isoprostanes; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine