title: Retrospective analysis of prenatal ultrasound of children with Hirschsprung disease.
abstract: OBJECTIVE
  Hirschsprung disease (HD) is a rare gastrointestinal disorder. Our aim was to study the prenatal ultrasound findings of children who were diagnosed with HD after birth.
  
  
  METHODS
  The study population included children who suffered from HD between 1990 and 2008. Data of anomaly scan findings in prenatal ultrasound, demographic and post-natal physical abnormalities and treatment were retrieved from medical files and interviews with the parents.
  
  
  RESULTS
  Twenty-two patients confirmed histopathological diagnosis of HD at age of 1 day to 15 months. Nineteen fetuses had anomaly scan during pregnancy, which revealed minor sonographic abnormalities in three fetuses; two of them had hyperechogenic bowel. One fetus with hyperechogenic bowel had polyhydramnion, and another had a family history of three brothers with HD. A third fetus had dilated pelvic kidney. None of them had sonographic evidence of bowel dilatation. After birth, six patients (31%) were found to have other structural anomalies: ventriculoseptal defect, atriseptal defect, atrio-ventricular septal defect, and pyloric stenosis.
  
  
  CONCLUSIONS
  Abnormal sonographic findings of fetal bowel are absent in the vast majority of fetuses who are diagnosed with HD after birth. In women with a family history of HD, a third trimester anomaly scan may be warranted.
authors: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.|Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors: Ariella
authors: A
authors: Jakobson-Setton
authors: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.|Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors: Alina
authors: A
authors: Weissmann-Brenner
authors: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.|Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors: Reuven
authors: R
authors: Achiron
authors: Department of Neonatology Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Ramat Gan, Israel.
authors: Jacob
authors: J
authors: Kuint
authors: Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.|Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel.
authors: Liat
authors: L
authors: Gindes
mesh_terms: D058535:Echogenic Bowel / Q000000981:diagnostic imaging; D005260:Female; D006627:Hirschsprung Disease / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal