title: Low-dose mannitol (0.3 g kg(-1)) improves the pulsatility index and minimum diastolic blood flow velocity in traumatic brain injury.
abstract: OBJECTIVE
  The aim of the study was to investigate the effects of using low-dose mannitol (0.3 g kg(-1)) on the pulsatility index (PI) and minimum diastolic blood flow velocity (FV-min) of the middle cerebral artery in a traumatic brain injury (TBI).
  
  
  METHODS
  Low-dose mannitol (0.3 g kg(-1)) was administered to a group of 20 patients with a TBI. Transcranial Doppler (TCD) ultrasonography was used to monitor the PI and FV-min. The study included patients with a diffuse traumatic brain injury and Glasgow coma score < 8. The initial TCD ultrasonography values were pathological (PI > 1.4 and FV-min < 20 cm s(-1)). TCD ultrasonography examinations were carried out before mannitol administration, immediately after administration and 1, 2 and 3 hours after the administration of mannitol.
  
  
  RESULTS
  A one-way analysis of variance revealed significant changes in the PI (F = 8.392; p < 0.001) and FV-min (F = 8.291; p = 0.001) after the use of mannitol.
  
  
  CONCLUSIONS
  Low-dose mannitol administration appears to be efficacious for improving the indicators of disturbed circulation in a TBI (FV-min increase, PI decrease). The maximum decrease in the PI was recorded 1 hour after the administration of mannitol and was 10.9% of the initial value. The maximum increase in the FV-min was recorded 1 hour after administration and was 29.7% of the initial value. These changes were significant ∼ 2 hours later.
authors: Department of Anaesthesiology and Intensive Care Medicine .
authors: Zeljko
authors: Z
authors: Nincevic
authors: Julije
authors: J
authors: Mestrovic
authors: Jasna
authors: J
authors: Nincevic
authors: Zeljko
authors: Z
authors: Sundov
authors: Dorjan
authors: D
authors: Kuscevic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000187:drug effects* / Q000503:physiopathology; D011673:Pulsatile Flow / Q000187:drug effects; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D008353:Mannitol
keywords: Low-dose mannitol; minimum diastolic blood flow velocity; pulsatility index; transcranial Doppler ultrasonography; traumatic brain injury