title: Maternal plasma RNA sequencing.
abstract: This review discusses the question: which steps are essential or need to be optimized so that maternal plasma RNA sequencing for pre-eclampsia and related syndromes will become as specific and sensitive as maternal plasma DNA sequencing for trisomy?
authors: Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: cbm.oudejans@vumc.nl.
authors: Cees B M
authors: CB
authors: Oudejans
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D019295:Computational Biology; D005260:Female; D005820:Genetic Testing / Q000639:trends; D023281:Genomics / Q000379:methods / Q000639:trends; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000639:trends; D058977:Molecular Sequence Annotation; D010949:Plasma / Q000737:chemistry; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000009:adverse effects / Q000639:trends; D012313:RNA / Q000097:blood* / Q000737:chemistry; D017423:Sequence Analysis, RNA / Q000639:trends
chemical_list: D015415:Biomarkers; D012313:RNA
keywords: Maternal plasma; Pre-eclampsia; RNA sequencing