title: Advances in molecular signaling mechanisms of β-phenethyl isothiocyanate antitumor effects.
abstract: β-Phenethyl isothiocyanate (PEITC) is an important phytochemical from cruciferous vegetables and is being evaluated for chemotherapeutic activity in early phase clinical trials. Moreover, studies in cell culture and in animals found that the anticarcinogenic activities of PEITC involved all the major stages of tumor growth: initiation, promotion, and progression. A number of mechanisms have been proposed for the chemopreventive activities of this compound. Here, we focus on the major molecular signaling pathways for the anticancer activities of PEITC. These include (1) activation of apoptosis pathways; (2) induction of cell cycle arrest; and (3) inhibition of the survival pathways. Furthermore, we also discussed the regulation of drug-metabolizing enzymes, including cytochrome P450s, metabolizing enzymes, and multidrug resistance.
authors: †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.|‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
authors: Chong-Zhen
authors: CZ
authors: Qin
authors: §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
authors: Xue
authors: X
authors: Zhang
authors: §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
authors: Lan-Xiang
authors: LX
authors: Wu
authors: §Institute of Life Sciences, Chongqing Medical University, Chongqing, Chongqing 400016, China.
authors: Chun-Jie
authors: CJ
authors: Wen
authors: †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.|‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
authors: Lei
authors: L
authors: Hu
authors: †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.|‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
authors: Qiao-Li
authors: QL
authors: Lv
authors: †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.|‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
authors: Dong-Ya
authors: DY
authors: Shen
authors: †Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.|‡Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, P. R. China.
authors: Hong-Hao
authors: HH
authors: Zhou
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006801:Humans; D017879:Isothiocyanates / Q000494:pharmacology*; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D016328:NF-kappa B; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D017879:Isothiocyanates; D016328:NF-kappa B; C058305:phenethyl isothiocyanate
keywords: angiogenesis; apoptosis; cycle arrest; survival pathways; β-phenethyl isothiocyanate