title: Elevated oxidative stress monitored via the albumin-thiol redox state is correlated with matrix metalloproteinase-3 elevation in patients with rheumatoid arthritis.
abstract: BACKGROUND
  In rheumatoid arthritis (RA), matrix metalloproteinase-3 (MMP-3) and oxidative stress contribute to joint destruction. However, little is known about the relationship between MMP-3 and oxidative stress in RA.
  
  
  METHODS
  We measured the albumin-thiol redox state as a marker of oxidative stress, MMP-3, and the DAS-28 score calculated using CRP values among forty-seven patients (9 males and 38 females) with RA. According to the serum MMP-3 levels, they were divided into two groups (group A: within normal ranges of 36.9-121.0 ng/mL for men and 17.3-59.7 ng/mL for women; group B: above normal ranges).
  
  
  RESULTS
  The albumin-thiol redox state in group B was significantly oxidized compared with that in group A (p < 0.01). The percentage of oxidized albumin-thiol showed a positive correlation with serum MMP-3 (r = 0.52). DAS-28 and CRP were also correlated with the percentage of oxidized albumin-thiol (r = 0.46, r = 0.44).
  
  
  CONCLUSIONS
  The albumin-thiol redox state was significantly oxidized in correlation with serum MMP-3 elevation in RA.
authors: Kazuha
authors: K
authors: Kizaki
authors: Yusuke
authors: Y
authors: Yoshizumi
authors: Teppei
authors: T
authors: Takahashi
authors: Seiichi
authors: S
authors: Era
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012709:Serum Albumin / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D013438:Sulfhydryl Compounds; C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3