title: Interplay of vitamin D and metabolic syndrome: A review.
abstract: Vitamin D deficiency is a worldwide public health problem. Vitamin D deficiency plays key role in the pathophysiology of risk factors of metabolic syndrome which affect cardiovascular system, increase insulin resistance and obesity, stimulate rennin-angiotensin-aldosterone system that cause hypertension. The discovery of vitamin D receptor expressed ubiquitously in almost all body cells such as immune, vascular and myocardial cells, pancreatic beta cells, neurons and osteoblasts suggests an involvement of vitamin D mediated effects on metabolic syndrome. Moreover vitamin D deficiency as well as cardiovascular diseases and related risk factors frequently co-occur. This underlines the importance of understanding the role of vitamin D in the context of metabolic syndrome. The paper provides an insight into the physiology of vitamin D and relationship of vitamin D deficiency with risk factors of metabolic syndrome through observational and supplementation studies.
authors: Department of Food and Nutrition, Punjab Agricultural University, Ludhiana 141004, Punjab, India. Electronic address: priyankadwivedi16@gmail.com.
authors: Priyanka
authors: P
authors: Prasad
authors: Department of Food and Nutrition, Punjab Agricultural University, Ludhiana 141004, Punjab, India. Electronic address: dranitakochhar@yahoo.com.
authors: Anita
authors: A
authors: Kochhar
mesh_terms: D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism; D050171:Dyslipidemias / Q000150:complications / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism; D024821:Metabolic Syndrome / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D009765:Obesity / Q000150:complications / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000378:metabolism; D012307:Risk Factors; D014807:Vitamin D / Q000378:metabolism; D014808:Vitamin D Deficiency / Q000150:complications* / Q000503:physiopathology
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D
keywords: Cardiovascular disease; Cholecalciferol; Metabolic syndrome; Vitamin D