title: Oxalate Nephropathy After Continuous Infusion of High-Dose Vitamin C as an Adjunct to Burn Resuscitation.
abstract: Fluid resuscitation is the foundation of management in burn patients and is the topic of considerable research. One adjunct in burn resuscitation is continuous, high-dose vitamin C (ascorbic acid) infusion, which may reduce fluid requirements and thus decrease the risk for over resuscitation. Research in preclinical studies and clinical trials has shown continuous infusions of high-dose vitamin C to be beneficial with decrease in resuscitative volumes and limited adverse effects. However, high-dose and low-dose vitamin C supplementation has been shown to cause secondary calcium oxalate nephropathy, worsen acute kidney injury, and delay renal recovery in non-burn patients. To the best of our knowledge, the authors present the first case series in burn patients in whom calcium oxalate nephropathy has been identified after high-dose vitamin C therapy.
authors: From the *Department of Surgery, San Antonio Military Medical Center, Fort Sam Houston, Texas; †U.S. Army Institute of Surgical Research, JBSA, ‡Department of Pathology, San Antonio Military Medical Center, Fort Sam Houston, Texas; and §Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
authors: Michelle
authors: M
authors: Buehner
authors: Jeremy
authors: J
authors: Pamplin
authors: Lynette
authors: L
authors: Studer
authors: Rhome L
authors: RL
authors: Hughes
authors: Booker T
authors: BT
authors: King
authors: John C
authors: JC
authors: Graybill
authors: Kevin K
authors: KK
authors: Chung
mesh_terms: D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D002056:Burns / Q000628:therapy*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D010070:Oxalates / Q000009:adverse effects*; D012151:Resuscitation / Q000379:methods*; D055815:Young Adult
chemical_list: D010070:Oxalates; D001205:Ascorbic Acid