title: Ceftaroline fosamil as first-line versus second-line treatment for acute bacterial skin and skin structure infections (ABSSSI) or community-acquired bacterial pneumonia (CABP).
abstract: The Clinical Assessment Program and Teflaro(®) Utilization Registry (CAPTURE) is a multicenter registry study of acute bacterial skin and skin structure infection (ABSSSI) and community-acquired bacterial pneumonia (CABP) patients treated with ceftaroline fosamil in the US. Data for this analysis were collected between August 2011 and February 2013 at US study centres by randomly ordered chart review. Clinical success rates among ABSSSI patients were >81% when ceftaroline fosamil was used as first- or second-line therapy, including monotherapy and concurrent therapy. Among CABP patients, clinical success rates were >77% among first-line and second-line patients and patients who received first-line concurrent therapy or second line monotherapy or concurrent therapy. For CABP patients treated with ceftaroline fosamil as first-line monotherapy, the clinical success rate was 70%. Ceftaroline fosamil is an effective treatment option for patients with ABSSSI or CABP with similar clinical success rates when used as first-line or second-line treatment.
authors: a Infectious Diseases, Memorial Hermann-Texas Medical Center , Houston , TX , USA.
authors: David J
authors: DJ
authors: Guervil
authors: b Detroit Medical Center, Wayne State University , Detroit, MI, USA.
authors: Keith S
authors: KS
authors: Kaye
authors: c Alabama Infectious Disease Center , Huntsville , AL , USA.
authors: Ali
authors: A
authors: Hassoun
authors: d Cerexa, Inc. , Oakland , CA , USA.
authors: Phillip
authors: P
authors: Cole
authors: e Forest Laboratories, Inc. , New York , NY , USA.
authors: Xing-Yue
authors: XY
authors: Huang
authors: d Cerexa, Inc. , Oakland , CA , USA.
authors: H David
authors: HD
authors: Friedland
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012042:Registries; D012189:Retrospective Studies; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D000097583:Ceftaroline
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097583:Ceftaroline
keywords: ABSSSI; CAPTURE; Ceftaroline fosamil; First-line treatment; MRSA; Pneumonia; Second-line treatment