title: Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis.
abstract: Atherosclerosis is a chronic inflammatory disease of large arteries and, among others, characterized by continuous influx of monocytes into the subendothelial space, subsequent macrophage accumulation, and foam cell formation. Chemokines and their receptors tightly orchestrate monocyte trafficking and fate from birth to death. This brief review summarizes our current understanding of the interplay between monocytes and chemokines entertaining crucial processes in atherosclerosis development, progression, and regression.
authors: From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (M.D., J.D., O.S.); Department of Pathology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (M.D., O.S.). maik.drechsler@med.uni-muenchen.de oliver.soehnlein@gmail.com.
authors: Maik
authors: M
authors: Drechsler
authors: From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (M.D., J.D., O.S.); Department of Pathology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (M.D., O.S.).
authors: Johan
authors: J
authors: Duchene
authors: From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany (M.D., J.D., O.S.); Department of Pathology, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (M.D., O.S.). maik.drechsler@med.uni-muenchen.de oliver.soehnlein@gmail.com.
authors: Oliver
authors: O
authors: Soehnlein
mesh_terms: D050197:Atherosclerosis / Q000378:metabolism / Q000503:physiopathology*; D016923:Cell Death; D002465:Cell Movement / Q000502:physiology*; D018925:Chemokines / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism / Q000503:physiopathology*; D009000:Monocytes / Q000502:physiology*; D012680:Sensitivity and Specificity
chemical_list: D018925:Chemokines
keywords: atherosclerosis; chemokines; monocytes