title: Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock.
abstract: The circadian clock, a highly specialized, hierarchical network of biological pacemakers, directs and maintains proper rhythms in endocrine and metabolic pathways required for organism homeostasis. The clock adapts to environmental changes, specifically daily light-dark cycles, as well as rhythmic food intake. Nutritional challenges reprogram the clock, while time-specific food intake has been shown to have profound consequences on physiology. Importantly, a critical role in the clock-nutrition interplay appears to be played by the microbiota. The circadian clock appears to operate as a critical interface between nutrition and homeostasis, calling for more attention on the beneficial effects of chrono-nutrition.
authors: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: gad.asher@weizmann.ac.il.
authors: Gad
authors: G
authors: Asher
authors: Center for Epigenetics and Metabolism, Department of Biological Chemistry, U904 INSERM, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: psc@uci.edu.
authors: Paolo
authors: P
authors: Sassone-Corsi
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D004435:Eating; D041981:Gastrointestinal Tract / Q000382:microbiology* / Q000502:physiology*; D006801:Humans; D055432:Metabolomics