title: Influences of different vasopressors on stroke volume variation and pulse pressure variation.
abstract: Pulse pressure variation (PPV) and stroke volume variation (SVV) during mechanical ventilation have been shown to be effective parameters to predict preload responsiveness. Although induced hypertension decreases PPV and SVV, the influences of different vasopressors on PPV and SVV are unknown. 94 patients undergoing elective otologic surgery were randomly divided into three groups: Group P (patients were given phenylephrine), Group D (patients were given dopamine), Group E (patients were given ephedrine). When surgery was ongoing and the circulation state was stable, patients were given the vasopressor to increase the systolic arterial pressure (SAP) to the pre-calculated levels: low level, 10 % < ΔSAP ≤ 20 %; medium level, 20 % < ΔSAP ≤ 30 %; high level, 30 % < ΔSAP ≤ 40 %. When invasive arterial pressure reached the target value, PPV, SVV and other parameters were recorded. Dopamine decreased the PPV and SVV more significantly than ephedrine, but less significantly than phenylephrine. The influences of phenylephrine, dopamine and ephedrine on SVV and PPV are different due to their different pharmacological mechanisms.
authors: Department of Anesthesiology, People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
authors: Ran
authors: R
authors: Kong
authors: Department of Anesthesiology, People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
authors: Yi
authors: Y
authors: Liu
authors: Department of Anesthesiology, People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China. mwd1962@sina.cn.
authors: Weidong
authors: W
authors: Mi
authors: Department of Anesthesiology, People's Liberation Army General Hospital, 28 Fuxing Road, Haidian District, Beijing, 100853, China.
authors: Qiang
authors: Q
authors: Fu
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology*; D004298:Dopamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004809:Ephedrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D010656:Phenylephrine / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume / Q000187:drug effects* / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D004809:Ephedrine; D004298:Dopamine
keywords: Dopamine; Ephedrine; Phenylephrine; Pulse pressure variation; Stroke volume variation