title: Transfusion and management of surgical patients with hematologic disorders.
abstract: Clinical trials have provided guidance in developing triggers for transfusing in the hemodynamically stable patient. These studies have identified that improved outcomes can be obtained in the massively transfused patient when platelets and fresh frozen plasma are transfused with packed red blood cells. Studies that characterize the complications of transfusions, such as transfusion-related acute lung injury and poor cancer-related outcomes, are discussed. Emerging data that characterize the risk factors associated with transfusion-related acute lung injury and suggest metastasis and local recurrence occur at a higher rate in the transfused patient are discussed. Hematologic disorders commonly encountered by surgeons are discussed.
authors: Department of Clinical Sciences, Florida State University College of Medicine, 1401 Centerville Road, Suite 107, Tallahassee, FL 32308, USA. Electronic address: wade.douglas@med.fsu.edu.
authors: Wade G
authors: WG
authors: Douglas
authors: Department of Surgery, Marshall University Joan C. Edwards School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA.
authors: Ekong
authors: E
authors: Uffort
authors: Department of Surgery, Marshall University Joan C. Edwards School of Medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA.
authors: David
authors: D
authors: Denning
mesh_terms: D001803:Blood Transfusion; D006402:Hematologic Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D018579:Patient Selection; D019990:Perioperative Care
chemical_list: D006454:Hemoglobins
keywords: Massive transfusion protocols; Transfusion; Transfusion-related lung injury; Transfusion-related outcomes