title: Larva migrans in squirrel monkeys experimentally infected with Baylisascaris potosis.
abstract: Roundworms of the genus Baylisascaris are natural parasites primarily of wild carnivores, and they can occasionally cause infection in humans and animals. Infection results in visceral larva migrans and/or neural larva migrans, which can be severe or fatal in some animals. Recently, Baylisascaris nematodes isolated from kinkajous (Potos flavus) and previously referred to as Baylisascaris procyonis were renamed as Baylisascaris potosis; however, data regarding the pathogenicity of B. potosis towards animals and humans are lacking. In the present study, we experimentally infected squirrel monkeys (Saimiri sciureus) with B. potosis to determine the suitability of the monkey as a primate model. We used embryonated eggs of B. potosis at two different doses (10,000 eggs and 100,000 eggs) and examined the animals at 30 days post-infection. Histopathological examination showed the presence of B. potosis larvae and infiltration of inflammatory cells around a central B. potosis larvae in the brain, intestines, and liver. Nevertheless, the monkeys showed no clinical signs associated with infection. Parasitological examination revealed the presence of B. potosis larvae in the intestines, liver, lung, muscles, brain, kidney, and diaphragm. Our findings extend the range of species that are susceptible to B. potosis and provide evidence for the zoonotic potential of larva migrans in high dose infections.
authors: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Toshihiro
authors: T
authors: Tokiwa
authors: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors: Kosuke
authors: K
authors: Tsugo
authors: Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Azabu University, 1-17-71, Chuo-ku, Sagamihara, Kanagawa 2525-5201, Japan.
authors: Shohei
authors: S
authors: Nakamura
authors: Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Azabu University, 1-17-71, Chuo-ku, Sagamihara, Kanagawa 2525-5201, Japan.
authors: Kensuke
authors: K
authors: Taira
authors: Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 1-17-71, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. Electronic address: une@azabu-u.ac.jp.
authors: Yumi
authors: Y
authors: Une
mesh_terms: D000818:Animals; D017191:Ascaridida Infections / Q000473:pathology*; D001199:Ascaridoidea / Q000166:cytology* / Q000472:pathogenicity; D001921:Brain / Q000469:parasitology; D003964:Diaphragm / Q000469:parasitology; D004195:Disease Models, Animal; D006801:Humans; D007422:Intestines / Q000469:parasitology; D007668:Kidney / Q000469:parasitology; D007814:Larva; D007815:Larva Migrans / Q000473:pathology*; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008297:Male; D009132:Muscles / Q000469:parasitology; D045988:Procyonidae / Q000469:parasitology*; D012453:Saimiri
keywords: Baylisascaris potosis; Kinkajou roundworm; Larva migrans; Pathogenicity; Squirrel monkey; Zoonosis