title: Integrating mechanical and biological control of cell proliferation through bioinspired multieffector materials.
abstract: In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bioinspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.
authors: Departament de Genètica & de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
authors: Joaquin
authors: J
authors: Seras-Franzoso
authors: Witold I
authors: WI
authors: Tatkiewicz
authors: Esther
authors: E
authors: Vazquez
authors: Elena
authors: E
authors: García-Fruitós
authors: Imma
authors: I
authors: Ratera
authors: Jaume
authors: J
authors: Veciana
authors: Antonio
authors: A
authors: Villaverde
mesh_terms: D058227:Amyloidogenic Proteins; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001861:Bone Regeneration; D002448:Cell Adhesion; D060846:Cell Engineering; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible; D016503:Drug Delivery Systems; D016326:Extracellular Matrix Proteins; D006801:Humans; D020100:Hydrogels; D050997:Nanomedicine; D018919:Neovascularization, Physiologic; D009416:Nerve Regeneration; D044968:Regenerative Medicine; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D058227:Amyloidogenic Proteins; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D016326:Extracellular Matrix Proteins; D020100:Hydrogels
keywords: BIOSCAFFOLDS; adhesion proteins; growth factor release; hydrogels; regenerative medicine; topography