title: Effect of novel curcumin-encapsulated chitosan-bioglass drug on bone and skin repair after gamma radiation: experimental study on a Wistar rat model.
abstract: Radiation therapy contributes to a significant increase in bone osteoporosis and skin loss. Various natural health products might be beneficial to reduce bone and skin alterations. Curcumin (CUR) medicines derived from natural plants have played an important role in health care. This study aims at synthesizing and evaluating the performance therapy of CUR-encapsulated bioglass-chitosan (CUR-BG-CH). In vitro, the antioxidant assay was evaluated by using 1,1-diphenyl-2-picrylhydrazyl free-radical (DPPH) scavenging and the nitroblue tetrazolium reduction. The CUR-BG-CH antimicrobial effects were tested in liquid media. In vivo, after rat (60) Co γ-radiation, the tissue wound-healing process was studied by grafting CUR and CUR-BG-CH in femoral condyle and dorsal skin rat tissue. The antioxidant studies indicated that CUR-BG-CH quenches free radicals more efficiently than unmodified CUR and had effective DPPH (91%) and superoxide anion (51%) radical scavenging activities. The CUR-BG-CH biomaterial exhibited an important antimicrobial activity against Staphylococcus aureus. The histomorphometric parameters showed amelioration in CUR-BG-CH-treated rats. An improved mechanical property was noticed (33.16 ± 5.0 HV) when compared with that of unmodified CUR group (23.15 ± 4.9 HV). A significant decrease in tumour necrosis factor-α cytokine production was noted in the CUR-BG-CH rats (90 pg/ml) as compared with that of unmodified CUR group (240 pg/ml). The total amount of hydroxyproline was significantly enhanced (33.5%) in CUR-BG-CH group as compared with that of control. Our findings suggested that CUR-BG-CH might have promising potential applications for wound healing.
authors: Campus de Beaulieu, University of Rennes 1, UMR CNRS 6226, Rennes, France; Animal Ecophysiology Laboratory, Department of Life Sciences, Sfax Faculty of Science, Sfax, Tunisia.
authors: S
authors: S
authors: Jebahi
authors: M
authors: M
authors: Saoudi
authors: L
authors: L
authors: Farhat
authors: H
authors: H
authors: Oudadesse
authors: T
authors: T
authors: Rebai
authors: A
authors: A
authors: Kabir
authors: A
authors: A
authors: El Feki
authors: H
authors: H
authors: Keskes
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D002516:Ceramics / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D005720:Gamma Rays; D006909:Hydroxyproline / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D013211:Staphylococcus aureus / Q000187:drug effects; D014916:Whole-Body Irradiation; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects
chemical_list: C022107:Bioglass; D004337:Drug Carriers; D016166:Free Radical Scavengers; D018836:Inflammation Mediators; D048271:Chitosan; D003474:Curcumin; D006909:Hydroxyproline
keywords: bioglass; bone; chitosan; curcumin; irradiation; osteoporosis; skin