title: Decreased regional activity and network homogeneity of the fronto-limbic network at rest in drug-naive major depressive disorder.
abstract: OBJECTIVE
  The fronto-limbic network is implicated in the neurobiology of major depressive disorder. However, no studies are designed to assess directly the abnormalities of regional activity and network homogeneity of this network in major depressive disorder.
  
  
  METHODS
  A total of 44 drug-naive major depressive disorder patients and 44 healthy controls participated in the study, and resting-state functional magnetic resonance imaging data were obtained. The fractional amplitude of low-frequency fluctuations and network homogeneity methods were employed to analyze the data.
  
  
  RESULTS
  Compared with the controls, the patients exhibited reduced fractional amplitude of low-frequency fluctuations in the right middle frontal gyrus (orbital part) and decreased network homogeneity in the left middle frontal gyrus. There was no correlation between abnormal fractional amplitude of low-frequency fluctuations/network homogeneity and clinical variables.
  
  
  CONCLUSIONS
  Our findings suggest that decreased regional activity and network homogeneity in the frontal cortex may be the key impairment of the fronto-limbic network in major depressive disorder, and thus highlight the importance of the fronto-limbic network in the neurobiology of major depressive disorder.
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China guowenbin76@163.com.
authors: Wenbin
authors: W
authors: Guo
authors: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
authors: Feng
authors: F
authors: Liu
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Miaoyu
authors: M
authors: Yu
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Jian
authors: J
authors: Zhang
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Zhikun
authors: Z
authors: Zhang
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Jianrong
authors: J
authors: Liu
authors: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors: Changqing
authors: C
authors: Xiao
authors: Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, China.
authors: Jingping
authors: J
authors: Zhao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D059907:Functional Neuroimaging; D006801:Humans; D065726:Limbic Lobe / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology
keywords: Major depressive disorder; fractional amplitude of low-frequency fluctuations; fronto-limbic network; network homogeneity