title: Tau phosphorylation at serine 396 residue is required for hippocampal LTD.
abstract: Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom, School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom.
authors: Philip
authors: P
authors: Regan
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom, Chonnam-Bristol Frontier Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Gwangju 501-757, Republic of Korea, and.
authors: Thomas
authors: http://orcid.org/0000-0003-1015-3417
authors: T
authors: Piers
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and.
authors: Jee-Hyun
authors: JH
authors: Yi
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and.
authors: Dong-Hyun
authors: DH
authors: Kim
authors: Chonnam-Bristol Frontier Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Gwangju 501-757, Republic of Korea, and.
authors: Seonghoo
authors: S
authors: Huh
authors: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Se Jin
authors: SJ
authors: Park
authors: Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors: Jong Hoon
authors: JH
authors: Ryu
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom, Chonnam-Bristol Frontier Laboratory, Biomedical Research Institute, Chonnam National University Hospital, Gwangju 501-757, Republic of Korea, and.
authors: Daniel J
authors: DJ
authors: Whitcomb
authors: Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, School of Clinical Sciences, Faculty of Medicine and Dentistry, and Centre for Synaptic Plasticity, University of Bristol, Bristol BS1 3NY, United Kingdom, kei.cho@bristol.ac.uk.
authors: Kwangwook
authors: K
authors: Cho
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism; D012193:Reversal Learning / Q000502:physiology; D012694:Serine / Q000378:metabolism; D016875:tau Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D018091:Receptors, AMPA; D016875:tau Proteins; D012694:Serine
keywords: LTD; hippocampus; synaptic plasticity