title: Systemic mastocytosis with recurrent anaphylactic shock and multiple organ dysfunction failure.
abstract: BACKGROUND
  Systemic mastocytosis (SM) is a rare neoplasm. The symptoms of this disease vary among patients. The authors describe a rare case of SM with recurrent anaphylactic shock and multiple organ dysfunction failure.
  
  
  METHODS
  Hematologic investigation, bone marrow aspirate and biopsy, and cytogenetic analysis were performed.
  
  
  RESULTS
  The patient was rescued with positive treatment, administered on prednisolone and H1/H2-receptor blocking agents. Corticosteroid and IFN-α treatment have no significant effect on tumor burden, but no more anaphylactic shock occurred.
  
  
  CONCLUSIONS
  Cladribine and imatinib are recommended to treat SM patients to obtain a better therapeutic effect. Maybe allogeneic hematopoietic stem cell transplantation is a cure for SM.
authors: Guoshu
authors: G
authors: Chen
authors: Li
authors: L
authors: Chen
authors: Xiaohua
authors: X
authors: Qin
authors: Xiaoling
authors: X
authors: Xie
authors: Guowei
authors: G
authors: Li
authors: Bing
authors: B
authors: Xu
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology*; D005260:Female; D006801:Humans; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000175:diagnosis*; D009102:Multiple Organ Failure / Q000209:etiology*