title: Effect of propane-2-sulfonic acid octadec-9-enyl-amide on the expression of adhesion molecules in human umbilical vein endothelial cells.
abstract: Oleoylethanolamide (OEA), an endogenous agonist of PPARα, has been reported to have anti-atherosclerotic properties. However, OEA can be enzymatically hydrolyzed to oleic acid and ethanolamine and, thus, is not expected to be orally active. In the present study, we designed and synthesized an OEA analog, propane-2-sulfonic acid octadec-9-enyl-amide (N15), which is resistant to enzymatic hydrolysis. The purpose of this study was to investigate the effects of N15 on the expression of adhesion molecules in human umbilical vein endothelial cells (HUVECs). The results showed that N15 inhibited TNFα-induced production of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 and the adhesion of monocytes to TNFα-induced HUVECs. Furthermore, the protective effect of N15 on inflammation is dependent upon a PPAR-α/γ-mediated mechanism. In conclusion, N15 protects against TNFα-induced vascular endothelial inflammation. This anti-inflammatory effect of N15 is dependent on PPAR-α/γ dual targets.
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Cai-Xia
authors: CX
authors: Chen
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Li-Chao
authors: LC
authors: Yang
authors: Department of Cardiology, Zhongshan Hospital, Xiamen, China.
authors: Xu-Dong
authors: XD
authors: Xu
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Xiao
authors: X
authors: Wei
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Ya-Ting
authors: YT
authors: Gai
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Lu
authors: L
authors: Peng
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Han
authors: H
authors: Guo
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China.
authors: Hao-Zhou
authors: Department of Cardiology, Zhongshan Hospital, Xiamen, China.
authors: Yi-Qing
authors: YQ
authors: Wang
authors: Department of Basic Medical Sciences, Medical College, Xiamen University, Xiamen, China. Electronic address: xinjin@xmu.edu.cn.
authors: Xin
authors: X
authors: Jin
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002470:Cell Survival / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects*; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D047493:PPAR alpha / Q000096:biosynthesis / Q000235:genetics; D047495:PPAR gamma / Q000096:biosynthesis / Q000235:genetics; D011407:Propane / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000494:pharmacology*; D015533:Transcriptional Activation / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D047493:PPAR alpha; D047495:PPAR gamma; D013451:Sulfonic Acids; D014409:Tumor Necrosis Factor-alpha; C000604189:propane-2-sulfonic acid octadec-9-enyl-amide; D011407:Propane
keywords: Adhesion molecules; Atherosclerosis; Human umbilical vein endothelial cells; Peroxisome proliferator-activated receptor-α; Peroxisome proliferator-activated receptor-γ; Propane-2-sulfonic acid octadec-9-enyl-amide