title: Blood flow mechanics in cardiovascular development.
abstract: Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in different model organisms, it is possible to identify common mechanogenetic rules, which are strikingly conserved and shared in many tissues and species. Here, we discuss recent findings showing how hemodynamic forces potentially modulate cardiovascular development as well as the underlying fluid and tissue mechanics, with special attention given to the flow characteristics that are unique to the small scales of embryos.
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France, boselli@igbmc.fr.
authors: Francesco
authors: F
authors: Boselli
authors: Jonathan B
authors: JB
authors: Freund
authors: Julien
authors: J
authors: Vermot
mesh_terms: D001696:Biomechanical Phenomena; D002319:Cardiovascular System / Q000254:growth & development*; D053263:Gene Regulatory Networks / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008955:Models, Cardiovascular; D009024:Morphogenesis / Q000502:physiology*