title: Effects of adnexal torsion on the Fallopian tube in rats: a histologic and immunohistochemical study.
abstract: OBJECTIVE
  To investigate histopathological and immunohistochemical changes in the Fallopian tube structure following ovarian torsion.
  
  
  METHODS
  Thirty fertile, female, adult Wistar albino rats, weighing 200-220 g, were randomly divided into 3 equal groups (n = 10): sham, torsion, and detorsion. In the torsion and detorsion groups, bilateral adnexal torsion (3-hour ischemia) was carried out. Bilateral adnexal detorsion (3-hour reperfusion) was performed in the detorsion group. Fallopian tube sections were stained hematoxylin and eosin, periodic acid-Schiff, Mallory-Azan and immunohistochemically-stained desmin, α smooth actin, and CD68 antibodies.
  
  
  RESULTS
  In the sections of the ischemic group, degeneration of epithelium, loss of cilia, dilation of blood vessels, and hemorrhages were observed. Image analysis of the studied Fallopian section revealed a significant decrease in density of desmin in the torsion group. Moreover, strong positive cytoplasmic CD68 expression was observed in the torsion group.
  
  
  CONCLUSIONS
  The use of effective antiinflammatory treatments may contribute to the conservative surgery in preservation of ovarian reserve and tubal structure.
authors: Senem Yaman
authors: SY
authors: Tunç
authors: Elif
authors: E
authors: Ağaçayak
authors: Neval S
authors: NS
authors: Yaman
authors: Engin
authors: E
authors: Deveci
authors: Sevgi
authors: S
authors: Kalkanlı
authors: Ali
authors: A
authors: Özler
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D010049:Ovarian Diseases / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D015424:Reperfusion / Q000379:methods