title: In vivo electrochemical corrosion study of a CoCrMo biomedical alloy in human synovial fluids.
abstract: The present study was initiated with the aim to assess the in vivo electrochemical corrosion behaviour of CoCrMo biomedical alloys in human synovial fluids in an attempt to identify possible patient or pathology specific effects. For this, electrochemical measurements (open circuit potential OCP, polarization resistance Rp, potentiodynamic polarization curves, electrochemical impedance spectroscopy EIS) were carried out on fluids extracted from patients with different articular pathologies and prosthesis revisions. Those electrochemical measurements could be carried out with outstanding precision and signal stability. The results show that the corrosion behaviour of CoCrMo alloy in synovial fluids not only depends on material reactivity but also on the specific reactions of synovial fluid components, most likely involving reactive oxygen species. In some patients the latter were found to determine the whole cathodic and anodic electrochemical response. Depending on patients, corrosion rates varied significantly between 50 and 750 mg dm(-2)year(-1).
authors: Universidad Politecnica de Valencia UPV, Valencia, Spain.
authors: A
authors: A
authors: Igual Munoz
authors: Aesculap AG, Tuttlingen, Germany.
authors: J
authors: J
authors: Schwiesau
authors: Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
authors: B M
authors: BM
authors: Jolles
authors: Ecole Polytechnique Fédérale de Lausanne EPFL, Lausanne, Switzerland.
authors: S
authors: S
authors: Mischler
mesh_terms: D000497:Alloys / Q000378:metabolism*; D002857:Chromium / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D003343:Corrosion; D055664:Electrochemical Techniques; D006801:Humans; D008982:Molybdenum / Q000737:chemistry; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D000497:Alloys; D002857:Chromium; D003035:Cobalt; D008982:Molybdenum
keywords: CoCrMo alloy; Corrosion; Electrochemistry; Human synovia; Knee implants