title: Pretransplant vaccinations in allogeneic stem cell transplantation donors and recipients: an often-missed opportunity for immunoprotection?
abstract: Immune deficiency following hematopoietic cell transplantation predisposes the patient to potentially deadly infections. Vaccinations can improve immunity and thus reduce the morbidity and mortality associated with these infections. Over the years different sets of guidelines have been published the most recent by the Infectious Diseases Society of American (IDSA). There is limited evidence that vaccination of donors and/or recipients before transplantation may improve immunity. However, despite the possibility of augmented immunity, there remain logistical, ethical and medical concerns about such a vaccination strategy.
authors: Section of Hematology and Stem Cell Transplantation, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: A E
authors: AE
authors: Harris
authors: Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
authors: J
authors: J
authors: Styczynski
authors: Department of Pharmacy, Veterans Affairs Medical Center, Nashville, TN, USA.
authors: M
authors: M
authors: Bodge
authors: 1] Department of Haematology, Saint Antoine Hospital, Paris, France [2] INSERM UMR 938, Paris, France [3] Université Pierre et Marie Curie, Paris, France.
authors: M
authors: M
authors: Mohty
authors: Section of Hematology and Stem Cell Transplantation, Vanderbilt University Medical Center, Nashville, TN, USA.
authors: B N
authors: BN
authors: Savani
authors: 1] Departments of Hematology and Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden [2] Division of Hematology, Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden.
authors: P
authors: 0000000282813245
authors: P
authors: Ljungman
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods*; D014611:Vaccination / Q000379:methods*