title: Structural transformation: assembly of an otherwise inaccessible DNA nanocage.
abstract: A strategy of structural transformation for the assembly of DNA nanocages that can not be assembled directly is described. In this strategy, a precursor DNA nanocage is assembled first and then is isothermally transformed into a desired, complicated nanocage. A dramatic, conformational change accompanies the transformation. This strategy has been proven to be successful by native polyacrylamide gel electrophoresis (PAGE) and cryogenic electron microscopy (cryoEM) imaging. We expect that the strategy of structural transformation will be useful for the assembly of many otherwise inaccessible DNA nanostructures and help to increase the structural complexity of DNA nanocages.
authors: Department of Chemistry, Purdue University, West Lafayette, IN 47907 (USA).
authors: Yulin
authors: Y
authors: Li
authors: Cheng
authors: C
authors: Tian
authors: Zhiyu
authors: Z
authors: Liu
authors: Wen
authors: W
authors: Jiang
authors: Chengde
authors: C
authors: Mao
mesh_terms: D004247:DNA / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D063347:Native Polyacrylamide Gel Electrophoresis; D009690:Nucleic Acid Conformation
chemical_list: D004247:DNA
keywords: DNA nanocages; DNA structures; self-assembly; strand displacement