title: New nanoplatforms based on UCNPs linking with polyhedral oligomeric silsesquioxane (POSS) for multimodal bioimaging.
abstract: A new and facile method was used to transfer upconversion luminescent nanoparticles from hydrophobic to hydrophilic using polyhedral oligomeric silsesquioxane (POSS) linking on the surface of upconversion nanoparticles. In comparison with the unmodified upconversion nanoparticles, the POSS modified upconversion nanoplatforms [POSS-UCNPs(Er), POSS-UCNPs(Tm)] displayed good monodispersion in water and exhibited good water-solubility, while their particle size did not change substantially. Due to the low cytotoxicity and good biocompatibility as determined by methyl thiazolyl tetrazolium (MTT) assay and histology and hematology analysis, the POSS modified upconversion nanoplatforms were successfully applied to upconversion luminescence imaging of living cells in vitro and nude mouse in vivo (upon excitation at 980 nm). In addition, the doped Gd(3+) ion endows the POSS-UCNPs with effective T1 signal enhancement and the POSS-UCNPs were successfully applied to in vivo magnetic resonance imaging (MRI) for a Kunming mouse, which makes them potential MRI positive-contrast agents. More importantly, the corner organic groups of POSS can be easily modified, resulting in kinds of POSS-UCNPs with many potential applications. Therefore, the method and results may provide more exciting opportunities for multimodal bioimaging and multifunctional applications.
authors: Research Center of Nano Science and Technology, Shanghai University, Shanghai 200444, P. R. China. lnsun@shu.edu.cn.
authors: Xiaoqian
authors: X
authors: Ge
authors: Liang
authors: L
authors: Dong
authors: Lining
authors: L
authors: Sun
authors: Zhengmei
authors: Z
authors: Song
authors: Ruoyan
authors: R
authors: Wei
authors: Liyi
authors: L
authors: Shi
authors: Haige
authors: H
authors: Chen
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D019301:Oleic Acid / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry*; D014183:Transplantation, Heterologous
chemical_list: D000475:Alkenes; D003287:Contrast Media; D017646:Organosilicon Compounds; D019301:Oleic Acid; D005682:Gadolinium; C109760:1-octadecene