title: HDL particle subpopulations: Focus on biological function.
abstract: Low levels of high-density lipoprotein-cholesterol (HDL-C) constitute an independent biomarker of cardiovascular morbi-mortality. However, recent advances have drastically modified the classical and limited view of HDL as a carrier of 'good cholesterol', and have revealed unexpected levels of complexity in the circulating HDL particle pool. HDL particles are indeed highly heterogeneous in structure, intravascular metabolism and biological activity. This review describes recent progress in our understanding of HDL subpopulations and their biological activities, and focuses on relationships between the structural, compositional and functional heterogeneity of HDL particles.
authors: National Institute for Health and Medical Research (INSERM), UMR-ICAN 1166, Université Pierre et Marie Curie-Paris 6, AP-HP, Pitié-Salpétrière University Hospital, ICAN, Paris, France; Heart Institute-InCor, University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
authors: Fabiana H
authors: FH
authors: Rached
authors: M John
authors: MJ
authors: Chapman
authors: Anatol
authors: A
authors: Kontush
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology; D000975:Antioxidants / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology; D016632:Apolipoprotein A-I / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008076:Cholesterol, HDL / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology; D019610:Cytoprotection; D005343:Fibrinolytic Agents / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D058539:Phosphatidylinositol 3-Kinase / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D014665:Vasodilator Agents / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D016632:Apolipoprotein A-I; D015415:Biomarkers; D008076:Cholesterol, HDL; D005343:Fibrinolytic Agents; D014665:Vasodilator Agents; D058539:Phosphatidylinositol 3-Kinase; D051057:Proto-Oncogene Proteins c-akt
keywords: HDL subpopulations; HDL-C; functionality