title: Chondroitinase ABC improves recovery of long sciatic nerve defects.
abstract: Sciatic nerves from allogeneic Sprague-Dawley rats were pretreated with chondroitinase ABC and were used to bridge damaged sciatic nerves in Wistar rats. Chondroitin sulfate proteoglycans were removed from the chemically extracted acellular nerves. At 3 months after grafting, the footplate pinch test result was positive in the Wistar rats. Autotomy scores decreased, and increased muscular contraction tension appeared when triceps surae muscles were stimulated. In addition, the recovery rate of wet triceps surae muscle weight increased, and the distal segment of the chondroitinase ABC-treated graft exhibited Schwann cells next to the nerve fibers. These results suggested that chondroitinase ABC pretreatment enhanced repair of long nerve defects via acellular nerve grafting.
authors: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors: Hailong
authors: H
authors: Yu
authors: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang 110016, Liaoning Province, China.
authors: Liangbi
authors: L
authors: Xiang
authors: Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors: Wenjing
authors: W
authors: Xu
authors: Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors: Bin
authors: B
authors: Zhao
authors: Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors: Yu
authors: Y
authors: Wang
authors: Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors: Jiang
authors: J
authors: Peng
authors: Institute of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China.
authors: Shibi
authors: S
authors: Lu
keywords: Schwann cell; chondroitinase ABC; neural regeneration; peripheral nerve; sciatic nerve