title: Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair.
abstract: During meiotic prophase, the repair of induced DNA double-strand breaks (DSBs) promotes interactions between homologous chromosomes (homologs). A study by Joshi et al. (2015) now highlights how the global DSB activity in a nucleus influences the choice between the homolog and the sister chromatid for DSB repair.
authors: Institut Curie, CNRS UMR3664, Centre de Recherche, 26 rue d'Ulm 75248 Paris, France. Electronic address: valerie.borde@curie.fr.
authors: Valérie
authors: V
authors: Borde
authors: Institute of Human Genetics, UPR 1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France. Electronic address: bernard.de-massy@igh.cnrs.fr.
authors: Bernard
authors: B
authors: de Massy
mesh_terms: D053903:DNA Breaks, Double-Stranded; D059765:Homologous Recombination / Q000235:genetics*; D008540:Meiosis / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*