title: Prognostic significance of lymphoid enhancer-binding factor-1 expression in egyptian adult B-acute lymphocytic leukemia patients.
abstract: OBJECTIVE
  Lymphoid enhancer-binding factor-1 (LEF-1) is a key transcription factor of wingless-type (Wnt) signaling in various tumors and it is associated with a number of malignant diseases such as leukemia. We explored the expression profile of LEF-1 in acute lymphoblastic leukemia (ALL) and determined its specific prognostic significance in this disease.
  
  
  METHODS
  We studied LEF-1 expression in 56 newly diagnosed B-acute ALL adult patients using real-time quantitative polymerase chain reaction to investigate whether LEF-1 expression was associated with clinical patient characteristics and treatment outcomes.
  
  
  RESULTS
  High LEF-1 expression was associated with significantly poorer disease-free survival (p=0.03) and overall survival (p=0.005). Patients with high LEF-1 expression had a significantly higher relapse rate compared with low LEF-1 expression (p=0.01).
  
  
  CONCLUSIONS
  We provide evidence that high LEF-1 expression is a prognostic marker in adult B-acute ALL patients.
authors: Mansoura University Faculty of Medicine, Department of Clinical Pathology, Mansoura, Egypt. E-mail: rababzeadah@yahoo.com.
authors: Rabab M
authors: RM
authors: Aly
authors: Ansaf B
authors: AB
authors: Yousef