title: Bisphenol A and congenital developmental defects in humans.
abstract: Over 50% of the causes of fetal malformations in humans are still unknown. Recent evidence suggests the relationship between environmental exposure to endocrine disruptors and fetal malformations. Our study aims to establish the role of Bisphenol A (BPA), if any, in altering human reproduction. We enrolled 151 pregnant women who were divided into two groups: case group (CS, n=101), women with established diagnosis of developmental defect, and control group (CL, n=50), pregnant women with normally developed fetus. Total, free and conjugated BPA were measured in their blood using GC-MS with isotopic dilution. The results show a correlation between environmental exposure to BPA and the genesis of fetal malformations. Conjugated BPA, which was higher in the CL, casts light on the hypothesis that a reduced ability to metabolize the chemical in the mother can concur to the occurrence of malformation. In a more detailed manner, in case of chromosomal malformations, the average value of free BPA appears to be nearly three times greater than that of the controls. Similarly, in case of central and peripheral nervous system non-chromosomal malformations, the value of free BPA is nearly two times greater than that of the controls.
authors: Department of Medicine, University of Salerno, Italy.
authors: Maurizio
authors: M
authors: Guida
authors: Department of Medicine, University of Salerno, Italy. Electronic address: j.troisi@studenti.unisa.it.
authors: Jacopo
authors: J
authors: Troisi
authors: "G. Moscati" Hospital Avellino, Italy.
authors: Carla
authors: C
authors: Ciccone
authors: Department of Medicine, University of Salerno, Italy.
authors: Giovanni
authors: G
authors: Granozio
authors: Department of Medicine, University of Salerno, Italy.
authors: Cosimo
authors: C
authors: Cosimato
authors: Department of Medicine, "Federico II", University of Naples, Italy.
authors: Attilio
authors: A
authors: Di Spiezio Sardo
authors: Department of Medicine, "Federico II", University of Naples, Italy.
authors: Cinzia
authors: C
authors: Ferrara
authors: Department of Biology, "Federico II", University of Naples, Italy.
authors: Marco
authors: M
authors: Guida
authors: Department of Medicine, "Federico II", University of Naples, Italy.
authors: Carmine
authors: C
authors: Nappi
authors: Department of Medicine, University of Salerno, Italy.
authors: Fulvio
authors: F
authors: Zullo
authors: Department of Medicine, "Federico II", University of Naples, Italy.
authors: Costantino
authors: C
authors: Di Carlo
mesh_terms: D000328:Adult; D001559:Benzhydryl Compounds / Q000097:blood / Q000506:poisoning*; D002869:Chromosome Aberrations / Q000187:drug effects; D000013:Congenital Abnormalities / Q000097:blood / Q000209:etiology*; D004968:Estrogens, Non-Steroidal / Q000097:blood / Q000506:poisoning; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000187:drug effects*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects*; D010636:Phenols / Q000097:blood / Q000506:poisoning*; D011247:Pregnancy; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Endocrine disruptors; Fetal malformations