title: Ameliorative effect of gastrodin on 3,3'-iminodipropionitrile-induced memory impairment in rats.
abstract: 3,3'-Iminodipropionitrile (IDPN), one of the nitrile derivatives inducing neurotoxicity, causes the dyskinetic syndrome and cognitive impairment. Gastrodin is widely used to treat neurological disorders and showed to improve cognitive functions. The present study aimed to determine whether treatment with gastrodin can attenuate IDPN-induced impairment of memory consolidation in the passive avoidance (PA) task, and to explore the possible neural mechanisms. Our results showed that intragastric administration of gastrodin (200mg/kg) reversed the IDPN-induced impairment of memory consolidation as indicated by the prolonged retention latency in the PA task. Furthermore, gastrodin reverted IDPN-induced reduction of serotonin (5-HT) and elevation of serotonin turnover ratio. Gastrodin treatment prevented the increase of serotonin transporter (SERT) and the decrease of serotonin 1A (5-HT1A) receptor expression in the hippocampus of IDPN-treated rats. These results suggest that long-term gastrodin treatment could represent a novel pharmacological strategy for IDPN-induced memory impairment, as well that its protective effect is mediated through normalization of the serotoninergic system.
authors: Department of Physiology, Shandong University School of Medicine, Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors: Xiaona
authors: X
authors: Wang
authors: Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H8M5, Canada.
authors: Yuan
authors: Y
authors: Tan
authors: Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong University, Jingwu Weiqi Road, Jinan, Shandong 250021, PR China. Electronic address: Fengzhang2015@126.com.
authors: Feng
authors: F
authors: Zhang
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001592:Benzyl Alcohols / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D005960:Glucosides / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D009570:Nitriles / Q000633:toxicity*; D017208:Rats, Wistar; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism
chemical_list: D001592:Benzyl Alcohols; D004785:Environmental Pollutants; D005960:Glucosides; D009570:Nitriles; D050486:Serotonin Plasma Membrane Transport Proteins; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin; C008110:3,3'-iminodipropionitrile; C045345:gastrodin
keywords: 3,3′-Iminodipropionitrile; 5-HT; Gastrodin; Hippocampus; Passive avoidance task