title: [Prostasin (PRSS8) as a new pathological factor].
abstract: Serine proteases play pivotal roles in many biological processes including clotting, digestion, and immune system. A glycosylphosphatidylinositol-anchored serine protease prostasin(PRSS8) is ubiquitously expressed in many tissues such as kidney, prostate, skin, liver, lung, and colon. However, the physiological role for PRSS8 has not been fully understood. Recently, we have identified a novel role for PRSS8 in the regulation of glucose homeostasis via Toll-like receptor 4(TLR4)-mediated signaling in the liver and demonstrated new insight into the development of diabetes resulting from obesity-induced inflammation or metabolic endotoxemia. In this review, we provide an overview of current understanding of PRSS8 as a new pathological factor for human diseases.
authors: Kohei
authors: K
authors: Uchimura
authors: Kenichiro
authors: K
authors: Kitamura
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D053503:Epithelial Sodium Channels; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008099:Liver / Q000378:metabolism; D051379:Mice; D012697:Serine Endopeptidases / Q000502:physiology*; D000099271:Prostasin
chemical_list: D053503:Epithelial Sodium Channels; D012697:Serine Endopeptidases; D000099271:Prostasin