title: Casting a genome-wide net for learning mutants.
abstract: Wolman et al. (2015) report a forward genetic screen in zebrafish that implicated pregnancy-associated plasma protein-aa in habituation of the acoustic startle response. PAPP-AA is expressed in the underlying circuit, including Mauthner cells, and regulates habituation via IGF signaling.
authors: Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada.
authors: Evan L
authors: EL
authors: Ardiel
authors: Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada. Electronic address: crankin@psych.ubc.ca.
authors: Catharine H
authors: CH
authors: Rankin
mesh_terms: D000818:Animals; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007858:Learning / Q000502:physiology*; D009154:Mutation / Q000235:genetics*; D011247:Pregnancy; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1