title: Cancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow.
abstract: The Cancer Research UK Centre (CRUK) for Drug Development (CDD) can trace its origins back to the Cancer Research Campaign Phase I/II Committee (created in 1980) and to date has tested over 120 potential cancer medicines in early-phase clinical trials. Five drugs are now registered, providing benefit to thousands of patients with cancer as part of their routine standard of care. In recent years, the CDD has established several different business and operating models that provide it with access to the pipelines of pharmaceutical and biotechnology companies. This has enabled potential new treatments to be taken into clinical development that might have otherwise languished on companies' shelves and has increased the number of drug combinations being explored in early-phase clinical trials.
authors: Centre for Drug Development, Cancer Research UK, Angel Building, 407 St John Street, London EC1V 4AD, UK. Electronic address: james.ritchie@cancer.org.uk.
authors: James W A
authors: JW
authors: Ritchie
authors: Centre for Drug Development, Cancer Research UK, Angel Building, 407 St John Street, London EC1V 4AD, UK.
authors: Robert J
authors: RJ
authors: Williams
mesh_terms: D000047:Academies and Institutes / Q000266:history / Q000639:trends*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000266:history / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003299:Cooperative Behavior; D004059:Diffusion of Innovation; D055808:Drug Discovery / Q000266:history / Q000639:trends*; D005544:Forecasting; D049674:History, 21st Century; D006801:Humans; D033183:Interdisciplinary Communication; D008495:Medical Oncology / Q000266:history / Q000639:trends*; D006113:United Kingdom
chemical_list: D000970:Antineoplastic Agents