title: Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection.
abstract: Homeostasis underpins at a systems level the regulatory control of immunity and metabolism. While physiologically these systems are often viewed as independent, there is increasing evidence showing a tight coupling between immune and metabolic functions. Critically upon infection, the homeostatic regulation for both immune and metabolic pathways is altered yet these changes are often investigated in isolation. Here, we summarise our current understanding of these processes in the context of a clinically relevant pathogen, cytomegalovirus. We synthesise from the literature an integrative view of a coupled immune-metabolic infection process, centred on sugar and lipid metabolism. We put forward the notion that understanding immune control of key metabolic enzymatic steps in infection will promote the future development of novel therapeutic modalities based on metabolic modifiers that either enhance protection or inhibit infection.
authors: Division of Pathway and Infection Medicine, Edinburgh Infectious Diseases, University of Edinburgh, Medical School, Edinburgh, Scotland, UK.
authors: Konstantinos
authors: K
authors: Kotzamanis
authors: Ana
authors: A
authors: Angulo
authors: Peter
authors: P
authors: Ghazal
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects; D054884:Host-Pathogen Interactions; D006801:Humans; D056747:Immunomodulation; D007239:Infections / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D050356:Lipid Metabolism / Q000187:drug effects