title: The effect of disease risk probability and disease type on interest in clinic-based versus direct-to-consumer genetic testing services.
abstract: The effect of disease-specific cognitions on interest in clinic-based and direct-to-consumer (DTC) genetic testing was assessed. Participants (N = 309) responded to an online hypothetical scenario and received genetic testing-related messages that varied by risk probability (25, 50, 75 %) and disease type (Alzheimer's disease vs. Type 2 Diabetes). Post-manipulation interest increased for both testing types, but was greater for clinic-based testing. Interest was greater for Type 2 Diabetes than for Alzheimer's disease, the latter perceived as more severe and likely, and less treatable and preventable. For DTC testing only, participants allocated to the high risk condition (75 %) had greater testing interest than those in the low (25 %) category. DTC testing is perceived as a viable, but less preferred, option compared with clinic-based testing. Particularly when considering DTC genetic testing, there is a need to emphasize subjective disease-related perceptions, including risk probability.
authors: Centre for Emotional Health, Macquarie University, Sydney, Australia. kerry.sherman@mq.edu.au.|Westmead Breast Cancer Institute, Westmead Hospital, Sydney, Australia. kerry.sherman@mq.edu.au.
authors: Kerry
authors: K
authors: Sherman
authors: Department of Psychology, Macquarie University, Sydney, Australia.
authors: Laura-Kate
authors: LK
authors: Shaw
authors: National Drug and Alcohol Research Centre, University of NSW, Sydney, Australia.
authors: Katrina
authors: K
authors: Champion
authors: University of Heidelberg, Heidelberg, Germany.
authors: Fernanda
authors: F
authors: Caldeira
authors: Department of Psychology, Macquarie University, Sydney, Australia.
authors: Margaret
authors: M
authors: McCaskill
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D000067108:Direct-To-Consumer Screening and Testing; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010465:Perception; D055815:Young Adult
keywords: Direct-to-consumer; Genetic testing; Perceived manageability; Perceived severity; Risk probability