title: [Tizanidine withdrawal symptoms in stress cardiomyopathy].
abstract: BACKGROUND
  An acute discontinuation of tizanidine, an alpha-2-agonistic muscle relaxant, is associated with reflex tachycardia, hypertension, tremor, hypertonicity and anxiety.
  
  
  METHODS
  We describe a 53-year-old patient with broken-heart syndrome, who developed serious tizanidine withdrawal symptoms after high-dosed long-term treatment within the framework of stress cardiomyopathy.
  
  
  CONCLUSIONS
  Central muscle relaxants like tizanidine might have an impact on the development of delirium. Tizanidine withdrawal should be considered in patients who manifest signs and symptoms of withdrawal from medications. The drug should be gradually reduced in dosage under observation by a psychiatrist. When prescribing tizanidine, the possible pharmacological side effects and interactions should be taken into careful account.
authors: Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Austria.
authors: S
authors: S
authors: Mörkl
authors: Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Austria.
authors: S A
authors: SA
authors: Bengesser
authors: Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Austria.
authors: H
authors: H
authors: Schöggl
authors: Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Austria.
authors: D
authors: D
authors: Bayer
authors: Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Austria.
authors: H P
authors: HP
authors: Kapfhammer
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D003000:Clonidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000009:adverse effects* / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology / Q000523:psychology*; D054549:Takotsubo Cardiomyopathy / Q000150:complications* / Q000188:drug therapy
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine