title: Magnetoencephalography Slow-Wave Detection in Patients with Mild Traumatic Brain Injury and Ongoing Symptoms Correlated with Long-Term Neuropsychological Outcome.
abstract: Mild traumatic brain injury (mTBI) is common in the United States, accounting for as many as 75-80% of all TBIs. It is recognized as a significant public health concern, but there are ongoing controversies regarding the etiology of persistent symptoms post-mTBI. This constellation of nonspecific symptoms is referred to as postconcussive syndrome (PCS). The present study combined results from magnetoencephalography (MEG) and cognitive assessment to examine group differences and relationships between brain activity and cognitive performance in 31 military and civilian individuals with a history of mTBI+PCS and 33 matched healthy control subjects. An operator-free analysis was used for MEG data to increase reliability of the technique. Subjects completed a comprehensive neuropsychological assessment, and measures of abnormal slow-wave activity from MEG were collected. Results demonstrated significant group differences on measures of executive functioning and processing speed. In addition, significant correlations between slow-wave activity on MEG and patterns of cognitive functioning were found in cortical areas, consistent with cognitive impairments on exams. Results provide more objective evidence that there may be subtle changes to the neurobiological integrity of the brain that can be detected by MEG. Further, these findings suggest that these abnormalities are associated with cognitive outcomes and may account, at least in part, for long-term PCS in those who have sustained an mTBI.
authors: 1 Research Services, VA San Diego Healthcare System , San Diego, California.|3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: Ashley
authors: A
authors: Robb Swan
authors: 4 Department of Neuroscience, University of California , San Diego, San Diego, California.
authors: Sharon
authors: S
authors: Nichols
authors: 5 Department of Community Health, National University , San Diego, California.
authors: Angela
authors: A
authors: Drake
authors: 1 Research Services, VA San Diego Healthcare System , San Diego, California.|3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: AnneMarie
authors: A
authors: Angeles
authors: 3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: Mithun
authors: M
authors: Diwakar
authors: 3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: Tao
authors: T
authors: Song
authors: 1 Research Services, VA San Diego Healthcare System , San Diego, California.|2 Radiology Services, VA San Diego Healthcare System , San Diego, California.|3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: Roland R
authors: RR
authors: Lee
authors: 1 Research Services, VA San Diego Healthcare System , San Diego, California.|2 Radiology Services, VA San Diego Healthcare System , San Diego, California.|3 Department of Radiology, University of California , San Diego, San Diego, California.
authors: Ming-Xiong
authors: MX
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D003071:Cognition; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D056344:Executive Function; D005260:Female; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D038223:Post-Concussion Syndrome / Q000150:complications / Q000503:physiopathology; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult
keywords: executive functioning; magnetoencephalography (MEG); mild traumatic brain injury (mTBI); neuropsychological testing; postconcussive syndrome (PCS)