title: Polymerized human placenta hemoglobin improves resuscitative efficacy of hydroxyethyl starch in a rat model of hemorrhagic shock.
abstract: This study was designed to investigate whether resuscitation with polymerized human placenta hemoglobin (PolyPHb) extended survival and the efficacy of hydroxyethyl starch (HES) in a rat model of hemorrhagic shock. After withdrawal of 39 ml of blood/kg, rats were randomly resuscitated with PolyPHb/HES or HES alone. Systemic, hemodynamic, and blood gas parameters, tissue oxygenation, and plasma erythropoietin (EPO) were evaluated. The results showed that resuscitation with PolyPHb/HES doubled the survival rate and maintained relatively high blood pressure and tissue oxygenation when compared with the results obtained using HES 130 alone. It is concluded that infusion of PolyPHb improves the resuscitative efficacy of HES in the present experimental conditions.
authors: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University , Chongqing , P. R. China.
authors: Yaojin
authors: Y
authors: Li
authors: Dong
authors: D
authors: Yan
authors: Shasha
authors: S
authors: Hao
authors: Shen
authors: S
authors: Li
authors: Wentao
authors: W
authors: Zhou
authors: Hong
authors: H
authors: Wang
authors: Jiaxin
authors: J
authors: Liu
authors: Xiang
authors: X
authors: Wang
authors: Chengmin
authors: C
authors: Yang
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006454:Hemoglobins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D008297:Male; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; C037158:polyhemoglobin
keywords: hemoglobin-based oxygen carriers; hemorrhagic shock; hydroxyethyl starch; survival; tissue oxygenation