title: Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus.
abstract: OBJECTIVE
  Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in patients with type 1 diabetes mellitus.
  
  
  METHODS
  We examined the relationship of the NLR to aortic stiffness in 76 people with type 1 diabetes and 36 healthy controls.
  
  
  RESULTS
  The NLRs in the group with type 1 diabetes were higher than in the controls (2.33±0.95 vs. 1.80±0.68, respectively; p=0.003). Aortic strain and aortic distensibility, the parameters of aortic stiffness, measured noninvasively by the help of echocardiography, were significantly decreased in the patient group compared to controls (8.0%±1.5% vs. 13.1%±3.3 %; p<0.001 and 3.6±1.1 cm(2).dyn(-1).10(-3) vs. 6.0±2.1 cm(2).dyn(-1).10(-3); p<0.001, respectively). There were negative correlations between NLR and distensibility (r: -0.40; p<0.001) and strain (r: -0.57; p<0.001) in patients with type 1 diabetes.
  
  
  CONCLUSIONS
  We have demonstrated that there is a significant negative correlation between the NLR and markers of aortic stiffness in patients with type 1 diabetes, indicating a potential association between inflammation and arterial stiffness. Accordingly, a higher NLR may be a useful additional measure in determining the cardiovascular risks of patients with type 1 diabetes in our clinical practice.
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey. Electronic address: huseyinayhan44@yahoo.com.
authors: Hüseyin
authors: H
authors: Ayhan
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Hacı Ahmet
authors: HA
authors: Kasapkara
authors: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors: Abdullah Nabi
authors: AN
authors: Aslan
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Tahir
authors: T
authors: Durmaz
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Telat
authors: T
authors: Keleş
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Murat
authors: M
authors: Akçay
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Nihal
authors: N
authors: Akar Bayram
authors: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors: Serdal
authors: S
authors: Baştuğ
authors: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors: Emine
authors: E
authors: Bilen
authors: Department of Cardiology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors: Cenk
authors: C
authors: Sarı
authors: Department of Cardiology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors: Engin
authors: E
authors: Bozkurt
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: aortic stiffness; diabète sucré de type 1; echocardiography; inflammation; neutrophil to lymphocyte ratio; rapport neutrophiles/lymphocytes; rigidité aortique; type 1 diabetes mellitus; échocardiographie