title: Viruses in pulp and periapical inflammation: a review.
abstract: The presence of viruses in endodontic disease has been studied in the last decade. Their presence is associated with periapical radiolucency and with clinical findings, such as pain. The aim of this review is to analyze the scientific evidence currently published about viruses in pulp and periapical inflammation, and its possible clinical implications. A literature review was carried out using the Medline/Pubmed database. The search was performed, in English and Spanish, using the following keyword combinations: virus AND endodontic; virus AND periapical; virus AND pulpitis; herpesvirus AND periapical; papillomavirus AND periapical. We subsequently selected the most relevant studies, which complied with the search criterion. A total of 21 articles were included, of which 18 detected the present of viruses in the samples. In 3 of the studies, viral presence was not found in the samples studied. The Epstein-Barr virus was found in about 41 % of cases compared to controls, in which it was present in about 2 %. The main association between viruses and endodontic pathosis is between Cytomegalovirus and Epstein-Barr virus; these are found in 114 of the 406 samples of different endodontic pathosis. Some evidence supports that the Epstein-Barr virus is present in a significant number of endodontic diseases, without exact knowledge of their action in these diseases.
authors: Faculty of Medicine, School of Dentistry, Universidad Austral de Chile, Valdivia, Chile.|PhD Program in Odontology Science, Faculty of Dentistry, University of Barcelona, Barcelona, Spain.
authors: Scarlette
authors: S
authors: Hernández Vigueras
authors: Faculty of Medicine, School of Dentistry, Universidad Austral de Chile, Valdivia, Chile.
authors: Manuel
authors: M
authors: Donoso Zúñiga
authors: Department of Odonto-Stomatology, School of Dentistry, University of Barcelona, Barcelona, Spain.
authors: Enric
authors: E
authors: Jané-Salas
authors: Laboratory of Molecular Biology and Pharmacogenetics, Department of Basic Science, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.
authors: Luis
authors: L
authors: Salazar Navarrete
authors: Department of Stomatology Endodontics, University Sevilla, Seville, Spain.
authors: Juan José
authors: JJ
authors: Segura-Egea
authors: Department of Stomatology Endodontics, University Sevilla, Seville, Spain.
authors: Eugenio
authors: E
authors: Velasco-Ortega
authors: Department of Odonto-Stomatology, School of Dentistry, University of Barcelona, Barcelona, Spain. 18575jll@gmail.com.|Department of Odontostomatology, Pabellón de Gobierno 2ª Planta, Bellvitge University Campus, C/Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Barcelona, Spain. 18575jll@gmail.com.
authors: José
authors: J
authors: López-López
mesh_terms: D003587:Cytomegalovirus / Q000302:isolation & purification*; D003782:Dental Pulp / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007249:Inflammation; D010485:Periapical Periodontitis / Q000821:virology*
keywords: Apical periodontitis; Epstein–Barr virus; Herpesvirus; Human cytomegalovirus; Papillomavirus