title: Pathogenicity of 2 porcine deltacoronavirus strains in gnotobiotic pigs.
abstract: To verify whether porcine deltacoronavirus infection induces disease, we inoculated gnotobiotic pigs with 2 virus strains (OH-FD22 and OH-FD100) identified by 2 specific reverse transcription PCRs. At 21-120 h postinoculation, pigs exhibited severe diarrhea, vomiting, fecal shedding of virus, and severe atrophic enteritis. These findings confirm that these 2 strains are enteropathogenic in pigs.
authors: Kwonil
authors: K
authors: Jung
authors: Hui
authors: H
authors: Hu
authors: Bryan
authors: B
authors: Eyerly
authors: Zhongyan
authors: Z
authors: Lu
authors: Juliet
authors: J
authors: Chepngeno
authors: Linda J
authors: LJ
authors: Saif
mesh_terms: D000818:Animals; D017934:Coronavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D018352:Coronavirus Infections / Q000662:veterinary*; D007413:Intestinal Mucosa / Q000473:pathology / Q000821:virology; D012367:RNA, Viral; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis / Q000473:pathology / Q000821:virology*
chemical_list: D012367:RNA, Viral
keywords: PCR; PDCoV; coronavirus; gnotobiotic pigs; pathogenicity; pigs; porcine deltacoronavirus; strain OH-FD100; strain OH-FD22; strains; viruses