title: Plasma H2S predicts coronary artery lesions in children with Kawasaki disease.
abstract: BACKGROUND
  The aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).
  
  
  METHODS
  A prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2 S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.
  
  
  RESULTS
  Plasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 µmol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.
  
  
  CONCLUSIONS
  Plasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.
authors: Department of Pediatrics, Peking University First Hospital.
authors: Yan
authors: Y
authors: Sun
authors: Department of Pediatric Cardiology, Beijing Children's Hospital.
authors: Yue
authors: Y
authors: Yuan
authors: Department of Pediatrics, Peking University First Hospital.
authors: Hui
authors: H
authors: Yan
authors: Department of Pediatrics, Peking University First Hospital.
authors: Hong
authors: H
authors: Wan
authors: Department of Medical Statistics, Peking University First Hospital.
authors: Xueying
authors: X
authors: Li
authors: Department of Pediatrics, Peking University First Hospital.
authors: Siyao
authors: S
authors: Chen
authors: Department of Pediatrics, Peking University First Hospital.
authors: Hongxia
authors: H
authors: Li
authors: Department of Physiology and Pathophysiology, Peking University Health Science Center.
authors: Chaoshu
authors: C
authors: Tang
authors: Department of Pediatrics, Peking University First Hospital.|Key Laboratory of Molecular Cardiology, Ministry of Education.
authors: Junbao
authors: J
authors: Du
authors: Department of Pediatrics, Beijing Anzhen Hospital, Beijing, China.
authors: Guiying
authors: G
authors: Liu
authors: Department of Pediatrics, Peking University First Hospital.
authors: Hongfang
authors: H
authors: Jin
mesh_terms: D000359:Aftercare; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve
chemical_list: D015415:Biomarkers; D006862:Hydrogen Sulfide
keywords: Kawasaki disease; hydrogen sulfide; inflammation; vasculitis