title: Therapeutic Effects of TianDiJingWan on the Aβ 25-35-Induced Alzheimer's Disease Model Rats.
abstract: The main purpose of this study was to demonstrate the therapeutic effects and mechanism of TDJW, a modern Chinese medicine prescription developed based on the basic traditional Chinese medicine theory of "tonifying the kidney essence," on the Aβ 25-35-induced AD rats. The AD model was established by the intracerebroventricular administrations of Aβ 25-35 into the hippocampus CA1 tissue of SD male rats. 72 rats were randomly divided into six groups: sham operation, AD model, donepezil, high TDJW group, medium TDJW group, and low TDJW group. After oral administration of TDJW, the results of Morris water maze and step-down test showed that the learning and memory abilities of AD rats were significantly improved. And biochemical measurement demonstrated that Ach and Glu in hippocampus tissues of AD rats were increased as well. Moreover, the Aβ deposits and p-Tau aggregations in hippocampus CA1 tissues of AD rats were attenuated as observed in the micrographs of immunohistochemistry study, and the results of ELISA indicated that the expressions of TNF-α, IL-1β, and IL-6 in hippocampus tissues were significantly decreased. In conclusion, the present study demonstrated that TDJW could be used as a promising therapeutic agent for the clinical applications of AD treatment in patients.
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Zhijie
authors: Z
authors: Li
authors: Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Qing
authors: Q
authors: Tong
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Huifang
authors: H
authors: Xu
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Li
authors: L
authors: Hu
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Rong
authors: R
authors: Zhao
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Fang
authors: F
authors: Zhou
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Wei
authors: W
authors: Pan
authors: Department of Encephalopathy, Wuhan Hospital of Traditional Chinese Medicine, Wuhan 430030, China.
authors: Li
authors: L
authors: Zhou