title: Non-neuronal cholinergic system in airways and lung cancer susceptibility.
abstract: In the airway tract acetylcholine (ACh) is known to be the mediator of the parasympathetic nervous system. However ACh is also synthesized by a large variety of non-neuronal cells. Strongest expression is documented in neuroendocrine and in epithelial cells (ciliated, basal and secretory elements). Growing evidence suggests that a cell-type specific Ach expression and release do exist and act with local autoparacrine loop in the non-neuronal airway compartment. Here we review the molecular mechanism by which Ach is involved in regulating various aspects of innate mucosal defense, including mucociliary clearance, regulation of macrophage activation as well as in promoting epithelial cells proliferation and conferring susceptibility to lung carcinoma onset. Importantly this non-neuronal cholinergic machinery is differently regulated than the neuronal one and could be specifically therapeutically targeted.
authors: Laboratory of Biochemistry & Genetics, Division of Pneumology, University and Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy ;
authors: Laura
authors: L
authors: Saracino
authors: Laboratory of Biochemistry & Genetics, Division of Pneumology, University and Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy ;
authors: Michele
authors: M
authors: Zorzetto
authors: Laboratory of Biochemistry & Genetics, Division of Pneumology, University and Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy ;
authors: Simona
authors: S
authors: Inghilleri
authors: Policlinico di Monza, University of Pavia, Monza 20025, Italy.
authors: Ernesto
authors: E
authors: Pozzi
authors: Laboratory of Biochemistry & Genetics, Division of Pneumology, University and Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy ;
authors: Giulia Maria
authors: GM
authors: Stella
keywords: Cholinergic system; actionable target; cancer susceptibility; innate defense; non-neuronal compartment