title: Molecular, cellular, and physiological significance of N-terminal acetylation.
abstract: Protein N-terminal acetylation is catalyzed by N-terminal acetyltransferases and represents one of the most common protein modifications in eukaryotes. An increasing number of studies report on the importance of N-terminal acetylation for protein degradation, complex formation, subcellular targeting, and protein folding. N-terminal acetyltransferases are recognized to play important roles in a diversity of cellular processes like apoptosis, cell proliferation, sister chromatid cohesion, and chromatin silencing and are even linked to the development of rare genetic disorders and cancer. This article summarizes our current knowledge on the implications of N-terminal acetylation at the protein, cellular, and physiological levels.
authors: Department of Molecular Biology, University of Bergen, Bergen, Norway.
authors: Henriette
authors: H
authors: Aksnes
authors: Department of Molecular Biology, University of Bergen, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
authors: Kristine
authors: K
authors: Hole
authors: Department of Molecular Biology, University of Bergen, Bergen, Norway; Department of Surgery, Haukeland University Hospital, Bergen, Norway.
authors: Thomas
authors: T
authors: Arnesen
mesh_terms: D000107:Acetylation; D000123:Acetyltransferases / Q000737:chemistry*; D000818:Animals; D017209:Apoptosis; D049109:Cell Proliferation; D002843:Chromatin / Q000737:chemistry; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D010641:Phenotype; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D013379:Substrate Specificity; D050880:p300-CBP Transcription Factors / Q000737:chemistry; D000099224:p300-CBP-Associated Factor
chemical_list: D000123:Acetyltransferases; D002843:Chromatin; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
keywords: Acetylome; Gcn5-related N-acetyltransferase; N-terminal acetylation; N-terminal acetyltransferase; NAT; Ogden syndrome