title: Successful topical rapamycin treatment for facial angiofibromata in two children.
abstract: Topical sirolimus, or rapamycin, is known to inhibit tumorigenesis in tuberous sclerosis. We report two cases of successful treatment of children with facial angiofibromata and summarize the encouraging evidence of the effectiveness of this therapy in the literature.
authors: Welsh Institute of Dermatology, University Hospital of Wales, Cardiff, Wales, UK.
authors: Emma V
authors: EV
authors: Pynn
authors: Welsh Institute of Dermatology, University Hospital of Wales, Cardiff, Wales, UK.
authors: Jemma
authors: J
authors: Collins
authors: Dermatology Department, Princess of Wales Hospital, Bridgend, Wales, UK.
authors: Prasad R Y
authors: PR
authors: Hunasehally
authors: Dermatology Department, Princess of Wales Hospital, Bridgend, Wales, UK.
authors: Jenny
authors: J
authors: Hughes
mesh_terms: D000287:Administration, Topical; D018322:Angiofibroma / Q000188:drug therapy*; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D005153:Facial Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D020123:Sirolimus / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000903:Antibiotics, Antineoplastic; D020123:Sirolimus