title: [Nucleotide receptors and actin cytoskeleton dynamics].
abstract: Signaling cascades evoked by P2Y2 receptor plays an important role in the phenomena dependent on the actin cytoskeleton dynamics endocy-tosis, cell division, adhesion, intracellular transport and migration. P2Y2R coupled with G proteins, in response to ATP or UTP activates Rac1 and RhoA proteins important factors in actin cytoskeletal reorganization and regulates the level of phosphatidylinositol-4,5-bisphosphate (PIP2) that binds directly to a variety of actin regulatory proteins and modulates their function. The P2Y2 nucleotide receptor contains the integrin-binding domain enables it to interact selectively with α(v)β3 and α(v)β5 integrins and is required for G0-mediated Rac1 activation. Interaction with α(v)β5 is necessary for coupling the P2Y2 receptor to G12 and subsequent activation of RhoA.
authors: Wanda
authors: W
authors: Kłopocka
authors: Jarosław
authors: J
authors: Korczyński
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D058473:Receptors, Purinergic P2Y2 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D058473:Receptors, Purinergic P2Y2; D000255:Adenosine Triphosphate; D019204:GTP-Binding Proteins; D014544:Uridine Triphosphate