title: Human allogeneic AB0/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy.
abstract: OBJECTIVE
  The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgical and pharmacological interventions, are mostly palliative, and there is no specific therapy focused on restoring injured brain function.
  
  
  METHODS
  During a post-registration clinical investigation, the safety and efficacy of intravenous infusion of allogeneic human leukocyte antigen (HLA)-unmatched umbilical cord blood (UCB) cells were studied in 80 pediatric patients with cerebral palsy and associated neurological complications. Patients received up to 6 intravenous infusions of AB0/Rh-identical, red blood cell-depleted UCB cells at an average dose of 250 × 10(6) viable cells per infusion.
  
  
  RESULTS
  Patients were followed for 3-36 months, and multiple cell infusions did not cause any adverse effects. In contrast, in most patients who received four or more UCB cell infusions, positive dynamics related to significant improvements in neurological status and/or cognitive functions were observed.
  
  
  CONCLUSIONS
  The results confirm that multiple intravenous infusions of allogeneic AB0/Rh-identical UCB cells may be a safe and effective procedure and could be included in treatment and rehabilitation programs for juvenile patients with cerebral palsy.
authors: Laboratory of Human Stem Cells, National Cardiology Research Center, Moscow, Russian Federation. Electronic address: romanov@cardio.ru.
authors: Yury A
authors: YA
authors: Romanov
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Oleg P
authors: OP
authors: Tarakanov
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Sergey M
authors: SM
authors: Radaev
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Tamara N
authors: TN
authors: Dugina
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Svetlana S
authors: SS
authors: Ryaskina
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Anna N
authors: AN
authors: Darevskaya
authors: Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
authors: Yana V
authors: YV
authors: Morozova
authors: Polenov Institute of Neurosurgery, Saint-Petersburg, Russian Federation.
authors: William A
authors: WA
authors: Khachatryan
authors: Polenov Institute of Neurosurgery, Saint-Petersburg, Russian Federation.
authors: Konstantin E
authors: KE
authors: Lebedev
authors: Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors: Nelli S
authors: NS
authors: Zotova
authors: Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors: Anna S
authors: AS
authors: Burkova
authors: Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, Russian Federation.
authors: Gennady T
authors: GT
authors: Sukhikh
authors: Laboratory of Human Stem Cells, National Cardiology Research Center, Moscow, Russian Federation.
authors: Vladimir N
authors: VN
authors: Smirnov
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002547:Cerebral Palsy / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000637:transplantation*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D006680:HLA Antigens; D012204:Rh-Hr Blood-Group System
keywords: brain injury; cell therapy; cerebral palsy; umbilical cord blood