title: Novelty seeking in patients with right- versus left-onset Parkinson disease.
abstract: OBJECTIVE
  In patients with Parkinson disease, the personality trait "novelty seeking" has been linked to higher-than-normal risk for impulse control disorders. We measured novelty seeking to test whether side of onset of Parkinson disease predicted patients' risk for impulsivity.
  
  
  METHODS
  We evaluated 38 patients with Parkinson disease (19 right onset, 19 left onset) and 44 community-dwelling neurotypical controls. All participants completed demographic and mood measures and the Temperament and Character Inventory personality questionnaire. The right- and left-onset groups were nearly the same in background and clinical variables, including use of dopamine agonists.
  
  
  RESULTS
  The patients with right-onset disease exhibited significantly higher levels of novelty seeking than the patients with left-onset disease.
  
  
  CONCLUSIONS
  Our results suggest that patients with right-onset Parkinson disease who are taking dopamine agonists and who exhibit high novelty seeking are at greater risk for developing impulse control disorders than are patients with left onset who are also taking dopamine agonists.
authors: *Naval Health Research Center, San Diego, California †Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston, Massachusetts ‡The Graduate School, Northcentral University, Prescott Valley, Arizona.
authors: Erica
authors: E
authors: Harris
authors: Patrick
authors: P
authors: McNamara
authors: Raymon
authors: R
authors: Durso
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000209:etiology*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005106:Exploratory Behavior; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000473:pathology* / Q000523:psychology*; D010555:Personality Inventory; D012107:Research Design; D012306:Risk; D011795:Surveys and Questionnaires; D013694:Temperament
chemical_list: D018491:Dopamine Agonists