title: Lower bone turnover markers in metabolic syndrome and diabetes: the population-based Study of Health in Pomerania.
abstract: OBJECTIVE
  Accumulating evidence demonstrates an important interaction between bone and energy metabolism. We aimed to study the associations of three bone turnover markers (BTM: osteocalcin, beta-crosslaps, procollagen type 1 N-terminal propeptide) as well as of 25-hydroxyvitamin D and parathyroid hormone with metabolic syndrome (MetS) or type 2 diabetes mellitus (T2DM) in a large population-based cohort.
  
  
  RESULTS
  This cross-sectional study comprised 2671 adult men and women participating in the first follow-up of the population-based Study of Health in Pomerania (SHIP-1). Multivariable logistic regression analyses were performed to assess sex-specific associations between the BTMs, 25-hydroxyvitamin D or parathyroid hormone and metabolic disease. All models were adjusted for age, body mass index, smoking status, physical activity, estimated glomerular filtration rate and month of blood sampling. The models for women were further adjusted for menopausal status. Higher BTM or 25-hydroxyvitamin D concentrations were associated with significantly lower odds for metabolic disease, while there was no association between parathyroid hormone and MetS or T2DM.
  
  
  CONCLUSIONS
  Our results contribute to the accumulating evidence of a cross-sectional association between high BTM or 25-hydroxyvitamin D concentrations and a lower prevalence of MetS or T2DM. Further research is necessary to evaluate the mechanisms underlying these results.
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria; University Women's Hospital, Heidelberg, Germany.
authors: E
authors: E
authors: Lerchbaum
authors: Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Austria.
authors: V
authors: V
authors: Schwetz
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.
authors: M
authors: M
authors: Nauck
authors: Institute for Community Medicine, University Medicine Greifswald, Germany.
authors: H
authors: H
authors: Völzke
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany.
authors: H
authors: H
authors: Wallaschofski
authors: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany. Electronic address: anke.hannemann@uni-greifswald.de.
authors: A
authors: A
authors: Hannemann
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D015331:Cohort Studies; D003094:Collagen / Q000097:blood*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000378:metabolism*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D015995:Prevalence; D011347:Procollagen / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; C470125:PTH protein, human; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D011347:Procollagen; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D014807:Vitamin D; D003094:Collagen; C104450:25-hydroxyvitamin D
keywords: 25-hydroxyvitamin D; Beta-crosslaps; Osteocalcin; Procollagen type 1 N-terminal propeptide