title: WIP1 stimulates migration and invasion of salivary adenoid cystic carcinoma by inducing MMP-9 and VEGF-C.
abstract: The wild-type p53 induced phosphatase 1 (WIP1) is an oncogene overexpressed in a variety of human cancers. Here, we demonstrated that WIP1 silencing reduced MMP-9 and VEGF-C expression as well as migration and invasion of salivary adenoid cystic carcinoma (ACC) cells. Overexpression of MMP-9 or VEGF-C restored migration and invasion in WIP1 knockdown cells, indicating that MMP-9 and VEGF-C are downstream targets of WIP1 signaling. Levels of cyclin D1 and c-Myc, targets of Wnt/β-catenin pathway, were significantly decreased by WIP1 silencing. In addition, WIP1 expression was positively associated with metastasis and prognosis of ACC patients as well as with MMP-9 or VEGF-C in ACC tissues.
authors: Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.|State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Ya-ling
authors: YL
authors: Tang
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Xin
authors: X
authors: Liu
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Shi-yu
authors: SY
authors: Gao
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Hao
authors: H
authors: Feng
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Ya-ping
authors: YP
authors: Jiang
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Sha-sha
authors: SS
authors: Wang
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Jing
authors: J
authors: Yang
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Jian
authors: J
authors: Jiang
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Xiang-rui
authors: XR
authors: Ma
authors: Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, People's Republic of China.
authors: Ya-jie
authors: YJ
authors: Tang
authors: Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Yu
authors: Y
authors: Chen
authors: State Key Laboratory of Oral Diseases West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.|Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan 610041, People's Republic of China.
authors: Xin-hua
authors: XH
authors: Liang
mesh_terms: D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D018076:DNA, Complementary / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D064593:Heterografts; D006801:Humans; D053208:Kaplan-Meier Estimate; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000502:physiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D000071636:Protein Phosphatase 2C; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D011897:Random Allocation; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012468:Salivary Gland Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D015398:Signal Transduction; D014161:Transduction, Genetic; D014162:Transfection; D042582:Vascular Endothelial Growth Factor C / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D018076:DNA, Complementary; D009363:Neoplasm Proteins; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins; C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C; C000607458:PPM1D protein, human; D010749:Phosphoprotein Phosphatases; C000607468:Ppm1d protein, mouse; D000071636:Protein Phosphatase 2C; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
keywords: adenoid cystic carcinoma (ACC); invasion; metastasis; salivary gland; wild-type p53 induced phosphatase 1 (WIP1)