title: Abnormality of the corpus callosum in coalmine gas explosion-related posttraumatic stress disorder.
abstract: Abnormal corpus callosum (CC) has been reported in childhood trauma-related posttraumatic stress disorder (PTSD); however, the nature of white matter (WM) integrity alterations in the CC of young adult-onset PTSD patients is unknown. In this study, 14 victims of a coal mine gas explosion with PTSD and 23 matched coal miners without experiencing the coal mine explosion were enrolled. The differences in fractional anisotropy (FA) within 7 sub-regions of the CC were compared between the two groups. Compared to the controls, PTSD coal miners exhibited significantly reduced FA values in the anterior sub-regions of the CC (P < 0.05, Bonferroni-corrected), which mainly interconnect the bilateral frontal cortices. Our findings indicated that the anterior part of the CC was more severely impaired than the posterior part in young adult-onset PTSD, which suggested the patterns of CC impairment may depend on the developmental stage of the structure when the PTSD occurs.
authors: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors: Yang
authors: Y
authors: Zhang
authors: Department of Radiology of Jinmei Group General Hospital, Jincheng, Shanxi, 048006, China.
authors: Huabing
authors: H
authors: Li
authors: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors: Xu
authors: X
authors: Lang
authors: Department of Psychiatry, Anning Hospital of Tianjin City, Dongli District, Tianjin, 300300, China.
authors: Chuanjun
authors: C
authors: Zhuo
authors: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors: Wen
authors: W
authors: Qin
authors: Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
authors: Quan
authors: Q
authors: Zhang
mesh_terms: D000328:Adult; D016880:Anisotropy; D003031:Coal; D003337:Corpus Callosum / Q000473:pathology*; D005107:Explosions; D005740:Gases; D006801:Humans; D008297:Male; D008906:Mining; D015588:Observer Variation; D011712:Pyramidal Tracts / Q000473:pathology; D013313:Stress Disorders, Post-Traumatic / Q000473:pathology*
chemical_list: D003031:Coal; D005740:Gases