title: A non-invasive method to assess cerebral perfusion pressure in geriatric patients with suspected cerebrovascular disease.
abstract: BACKGROUND
  Cerebral perfusion pressure (CPP) can adversely impact cerebrovascular hemodynamics but cannot be practically measured in most clinical settings. Here, we aimed to establish a representative mathematical model for CPP in geriatric patients with suspected cerebrovascular disease.
  
  
  METHODS
  A total of 100 patients (54 males and 46 females between 60-80 years of age) with suspected cerebrovascular disease and no obvious cerebrovascular stenosis were selected for invasive CPP monitoring via catheterization of the middle segment of the common carotid arteries and openings of the vertebral arteries bilaterally. Curves were function-fitted using MATLAB 7.0, and data was statistically processed by SPSS 20.0.
  
  
  RESULTS
  MATLAB 7.0 constructed eighth-order Fourier functions that fit all recorded CPP curves. Since the coefficients of the 100 functions were significantly different, all functions were standardized to derive one representative function. By manipulating the heart rate and maximum/minimum CPP of the representative function, estimated CPP curves can be constructed for patients with differing heart rates, intracranial pressures (ICPs) and blood pressures.
  
  
  CONCLUSIONS
  CPP can be well-modeled through an eighth-order Fourier function that can be constructed from a patient's brachial artery blood pressure (BABP), ICP and heart rate. This function is representative of geriatric patients with cerebrovascular disease and can be used in the future study of cerebral hemodynamics.
authors: Department of Neurology, Yong Chuan Hospital, Chongqing Medical University, Chongqing, People's Republic of China; Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Bo
authors: B
authors: Liu
authors: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China; Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Qi
authors: Q
authors: Li
authors: Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
authors: Kewei
authors: K
authors: Li
authors: Department of Neurology, Yong Chuan Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Nan
authors: N
authors: Deng
authors: Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Peng
authors: P
authors: He
authors: Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
authors: Chunchang
authors: C
authors: Qin
authors: Department of Neurology, Yong Chuan Hospital, Chongqing Medical University, Chongqing, People's Republic of China; Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Deyu
authors: D
authors: Yang
authors: Department of Neurology, Yong Chuan Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Zhiwei
authors: Z
authors: Li
authors: Department of Neurology, Yong Chuan Hospital, Chongqing Medical University, Chongqing, People's Republic of China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China; Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing, People's Republic of China.
authors: Peng
authors: P
authors: Xie
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D017536:Carotid Artery, Common / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000503:physiopathology*; D003710:Demography; D005260:Female; D005851:Geriatric Nursing; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010361:Patients; D012984:Software; D014711:Vertebral Artery / Q000502:physiology