title: Selective reagent ionisation-time of flight-mass spectrometry: a rapid technology for the novel analysis of blends of new psychoactive substances.
abstract: In this study we demonstrate the potential of selective reagent ionisation-time of flight-mass spectrometry for the rapid and selective identification of a popular new psychoactive substance blend called 'synthacaine', a mixture that is supposed to imitate the sensory and intoxicating effects of cocaine. Reactions with H3O(+) result in protonated parent molecules which can be tentatively assigned to benzocaine and methiopropamine. However, by comparing the product ion branching ratios obtained at two reduced electric field values (90 and 170 Td) for two reagent ions (H3O(+) and NO(+)) to those of the pure chemicals, we show that identification is possible with a much higher level of confidence then when relying solely on the m/z of protonated parent molecules. A rapid and highly selective analytical identification of the constituents of a recreational drug is particularly crucial to medical personnel for the prompt medical treatment of overdoses, toxic effects or allergic reactions.
authors: IONICON Analytik GmbH., Eduard-Bodem-Gasse 3, 6020, Innsbruck, Austria; Institut für Ionenphysik und Angewandte Physik, Leopold-Franzens Universität Innsbruck, Technikerstr. 25, 6020, Innsbruck, Austria.
authors: Matteo
authors: M
authors: Lanza
authors: W Joe
authors: WJ
authors: Acton
authors: Philipp
authors: P
authors: Sulzer
authors: Kostiantyn
authors: K
authors: Breiev
authors: Simone
authors: S
authors: Jürschik
authors: Alfons
authors: A
authors: Jordan
authors: Eugen
authors: E
authors: Hartungen
authors: Gernot
authors: G
authors: Hanel
authors: Lukas
authors: L
authors: Märk
authors: Tilmann D
authors: TD
authors: Märk
authors: Chris A
authors: CA
authors: Mayhew
mesh_terms: D001566:Benzocaine / Q000032:analysis / Q000737:chemistry; D013287:Illicit Drugs / Q000032:analysis* / Q000737:chemistry; D013058:Mass Spectrometry / Q000379:methods*; D008694:Methamphetamine / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D011619:Psychotropic Drugs / Q000032:analysis* / Q000737:chemistry; D015813:Substance Abuse Detection / Q000379:methods*; D013876:Thiophenes / Q000032:analysis / Q000737:chemistry
chemical_list: C583008:1-(2-thienyl)-2-(methylamino)propane; D013287:Illicit Drugs; D011619:Psychotropic Drugs; D013876:Thiophenes; D008694:Methamphetamine; D001566:Benzocaine
keywords: PTR-MS; SRI-ToF-MS; drug detection; new psychoactive substances; synthacaine