title: Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.
abstract: BACKGROUND
  The American Thyroid Association appointed a Task Force of experts to revise the original Medullary Thyroid Carcinoma: Management Guidelines of the American Thyroid Association.
  
  
  METHODS
  The Task Force identified relevant articles using a systematic PubMed search, supplemented with additional published materials, and then created evidence-based recommendations, which were set in categories using criteria adapted from the United States Preventive Services Task Force Agency for Healthcare Research and Quality. The original guidelines provided abundant source material and an excellent organizational structure that served as the basis for the current revised document.
  
  
  RESULTS
  The revised guidelines are focused primarily on the diagnosis and treatment of patients with sporadic medullary thyroid carcinoma (MTC) and hereditary MTC.
  
  
  CONCLUSIONS
  The Task Force developed 67 evidence-based recommendations to assist clinicians in the care of patients with MTC. The Task Force considers the recommendations to represent current, rational, and optimal medical practice.
authors: 1Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors: Samuel A
authors: SA
authors: Wells
authors: 2Department of Pathology, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors: Sylvia L
authors: SL
authors: Asa
authors: 3Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, Germany.
authors: Henning
authors: H
authors: Dralle
authors: 4Department of Endocrinology, University of Pisa, Pisa, Italy.
authors: Rossella
authors: R
authors: Elisei
authors: 5Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: Douglas B
authors: DB
authors: Evans
authors: 6Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Robert F
authors: RF
authors: Gagel
authors: 7Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors: Nancy
authors: N
authors: Lee
authors: 3Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Halle/Saale, Germany.
authors: Andreas
authors: A
authors: Machens
authors: 8Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
authors: Jeffrey F
authors: JF
authors: Moley
authors: 9Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Siena, Italy.
authors: Furio
authors: F
authors: Pacini
authors: 10Endocrine Practice, Moleculargenetic Laboratory, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
authors: Friedhelm
authors: F
authors: Raue
authors: 10Endocrine Practice, Moleculargenetic Laboratory, Medical Faculty, University of Heidelberg, Heidelberg, Germany.
authors: Karin
authors: K
authors: Frank-Raue
authors: 11University of Sydney School of Medicine, Sydney, New South Wales, Australia.
authors: Bruce
authors: B
authors: Robinson
authors: 12Departments of Internal Medicine, Pediatrics and Behavioral Science, University of Kentucky, Lexington, Kentucky.
authors: M Sara
authors: MS
authors: Rosenthal
authors: 13Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita' di Napoli "Federico II," Napoli, Italy.
authors: Massimo
authors: M
authors: Santoro
authors: 14Institut Gustave Roussy, Service de Medecine Nucleaire, Université of Paris-Sud, Villejuif, France.
authors: Martin
authors: M
authors: Schlumberger
authors: 15Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio.
authors: Manisha
authors: M
authors: Shah
authors: 6Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors: Steven G
authors: SG
authors: Waguespack
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D044963:Biopsy, Fine-Needle; D018276:Carcinoma, Medullary / Q000151:congenital* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D019468:Disease Management; D005820:Genetic Testing; D020249:Hormone Replacement Therapy; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D018814:Multiple Endocrine Neoplasia Type 2b / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics; D011878:Radiotherapy / Q000379:methods*; D012955:Societies, Medical; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D013965:Thyroidectomy
chemical_list: D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human