title: Comparison of perioperative oxidative stress in endovascular and open repair of abdominal aortic aneurysm.
abstract: OBJECTIVE
  To investigate the differences in perioperative oxidative stress (OS) in abdominal aortic aneurysm (AAA) patients treated with either endovascular repair (EVAR) or open repair (OR).
  
  
  METHODS
  Twenty patients (11 OR, 9 EVAR) treated for AAA with no known malignant or inflammatory disease and an aneurysm diameter of over 5 cm and no rupture were included in the study. Blood samples were obtained preoperatively, during aortic occlusion, and 1 h and 24 h after reperfusion. Total antioxidant status (TAS), total oxidative stress (TOS), and malondialdehyde (MDA) levels were measured and oxidative stress index (OSI) was calculated.
  
  
  RESULTS
  OSI at 1 h and 24 h after reperfusion was higher in the EVAR group (P = 0.004 and P = 0.002, respectively). TAS levels were higher (P = 0.001, P = 0,029). MDA levels showed no difference (P = 0.291, P = 0.076). TOS levels were lower 24 h after reperfusion in the EVAR group (P = 0.018).
  
  
  CONCLUSIONS
  Markers of oxidative stress were lower in the EVAR group. This may be associated with advantages of EVAR. More studies are required for a clear-cut conclusion.
authors: Orhan Veli
authors: OV
authors: Doğan
authors: Ümit
authors: Ü
authors: Menteşe
authors: Süheyla
authors: S
authors: Doğan
authors: Sefer
authors: S
authors: Usta
authors: İbrahim
authors: İ
authors: Turan
authors: Ergüun
authors: E
authors: Haliloğlu
authors: Süleyman Caner
authors: SC
authors: Karahan
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000032:analysis; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D015331:Cohort Studies; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D059035:Perioperative Period; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde