title: Nanoscale materials for hyperthermal theranostics.
abstract: Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc.) that complement and extend the efficacy of traditional chemotherapy and surgery. This mini-review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods.
authors: Department of Chemistry, University of Washington, Seattle, Washington, USA.
authors: Bennett E
authors: BE
authors: Smith
authors: Paden B
authors: PB
authors: Roder
authors: Xuezhe
authors: X
authors: Zhou
authors: Peter J
authors: PJ
authors: Pauzauskie
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use; D011859:Radiography; D012666:Semiconductors; D000068936:Theranostic Nanomedicine
chemical_list: D004337:Drug Carriers; D037742:Nanotubes, Carbon; D017319:Photosensitizing Agents