title: Obesity and the use of antibiotics and probiotics in rats.
abstract: BACKGROUND
  Obesity has become a major public health challenge in recent years. Recent studies suggest that alterations of the gut microbiota by antibiotics could play an important role in obesity.
  
  
  METHODS
  We investigated this topic using 60 Wistar rats, which were divided into 3 experimental groups: rats treated with amoxicillin, rats treated with amoxicillin plus Saccharomyces boulardii and controls. Treatments were administered over the course of 2 weeks. Tetrapolar bioelectric impedance analysis and anthropometric evaluations were conducted.
  
  
  RESULTS
  The body mass index was significantly lower for the animals in the control group (p = 0.034). The same result was observed for the Lee index: the control group had a lower index than the 2 groups that received antibiotic treatment (p = 0.0019). The total body water data demonstrated that the control group had the greatest amount of body water (279.1 g, p = 0.0243).
  
  
  CONCLUSIONS
  The groups treated with the antibiotic exhibited a greater accumulation of body fat than the control group.
authors: Department of Pharmacology, University of Sorocaba, Sorocaba, Brazil.
authors: Fernando
authors: F
authors: de Sá Del Fiol
authors: Alessandra Cristina Marciano
authors: AC
authors: Tardelli Ferreira
authors: Jorge José
authors: JJ
authors: Marciano
authors: Maria Claudia
authors: MC
authors: Marques
authors: Luciane Lopes
authors: LL
authors: Sant'Ana
mesh_terms: D000273:Adipose Tissue / Q000382:microbiology; D000658:Amoxicillin / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015992:Body Mass Index; D008297:Male; D009765:Obesity / Q000188:drug therapy* / Q000382:microbiology*; D019936:Probiotics / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012440:Saccharomyces / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin