title: New oral anticoagulants versus vitamin K antagonists before cardioversion of atrial fibrillation: a meta-analysis of data from 4 randomized trials.
abstract: BACKGROUND
  Scarce data are available about efficacy and safety of new oral anticoagulants (NOACs) for cardioversion (CV) of atrial fibrillation (AF). We performed a meta-analysis of data from randomized studies reporting outcomes of patients receiving NOACs, as compared to vitamin K antagonists (VKAs), and undergoing CV of AF.
  
  
  METHODS
  Data from four studies were selected, including 4268 CVs. The primary endpoints were the incidence of stroke or systemic embolism and the incidence of major bleeding within 30 days.
  
  
  RESULTS
  There was not any significant difference in the incidence of stroke or systemic embolism between NOACs and VKAs (RR 0.73, p = 0.47) nor in the incidence of major bleeding (RR 1.39, p = 0.13).
  
  
  CONCLUSIONS
  We found no evidence of differential outcomes after CV of AF according to treatment with NOACs or VKAs. This finding warrants confirmation in larger clinical series and in the setting of properly powered randomized trials of newly diagnosed AF.
authors: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors: Giuseppe
authors: G
authors: Andò
authors: Olimpia
authors: O
authors: Trio
authors: Scipione
authors: S
authors: Carerj
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001281:Atrial Fibrillation / Q000150:complications / Q000628:therapy*; D004554:Electric Countershock / Q000379:methods; D004617:Embolism / Q000209:etiology; D006470:Hemorrhage / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D014812:Vitamin K
keywords: atrial fibrillation; cardioversion; new oral anticoagulants; stroke; vitamin K antagonists