title: Association between retinal artery lesions and nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  Retinal artery lesions have been reported to be a risk marker of morbidity and mortality for cardiovascular and cerebrovascular diseases in various study populations. Nonalcoholic fatty liver disease (NAFLD) is also a risk factor for cardiovascular disease. However, the relationship between retinal artery lesions and NAFLD is less certain.
  
  
  METHODS
  Data were obtained from 2,454 patients who attended their annual health examination (2,143 males and 311 females, aged 62.34 ± 10.03 years). NAFLD was diagnosed by hepatic ultrasonography. Retinal artery lesions were diagnosed according to the criteria. Total plasma cholesterol, plasma triglyceride and fasting glucose levels were determined by using a multichannel analyzer; the body mass index, systolic blood pressure, diastolic blood pressure, incidence of hypertension and coronary artery disease were measured or analyzed by statistical analysis.
  
  
  RESULTS
  Patients with NAFLD had older age and higher values of BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol and triglycerides and had a higher incidence of hypertension, coronary artery disease and retinal artery lesions (p < 0.01). Retinal artery lesions were taken as a dependent variable, and age, gender, BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol and triglyceride levels, and NAFLD were taken as covariates. We found that age ≥65 years (p < 0.01, OR 1.968), being male (p < 0.01, OR 1.668), BMI ≥ 25 (p < 0.01, OR 0.743), SBP ≥ 140 mmHg (p < 0.01, OR 1.368) and NAFLD (p < 0.01, OR 2.378) were significantly associated with a risk of retinal artery lesions by binary logistic regression analysis.
  
  
  CONCLUSIONS
  Patients with NAFLD were older and had higher values for BMI, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol and triglycerides, and higher incidence of hypertension, coronary artery disease and retinal artery lesions. NAFLD is a risk factor for retinal artery lesions.
authors: Geriatric Digestive System Department, Navy General Hospital, No. 6 Fuchenglu Road, Beijing, 100048, China, yangwen666123@sohu.com.
authors: Wen
authors: W
authors: Yang
authors: Hongtao
authors: H
authors: Xu
authors: Xiaohong
authors: X
authors: Yu
authors: Yuzhu
authors: Y
authors: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology*; D015995:Prevalence; D012161:Retinal Artery; D012164:Retinal Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography