title: Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma has very high incidence and high mortality worldwide. MiRNA is related to the tumorigenesis and metastasis of a variety of tumors. In the present study, we verify that the expression of miR-494 in NPC tissues and NPC-derived cells was down-regulated, respectively. The proliferation, colony formation, migration, and invasion of NPC-derived cells were suppressed, while the cell apoptosis was promoted, when miR-494 was over-expressed in these cells. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC.
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.|Guangzhou Medical University, 510000, Guangzhou, Guangdong Province, China.
authors: Hong-Fang
authors: HF
authors: Duan
authors: Department of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.|Shantou University Medical College, 515041, Shantou, Guangdong Province, China.
authors: Xiao-Qing
authors: XQ
authors: Li
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Hong-Yi
authors: HY
authors: Hu
authors: Shantou University Medical College, 515041, Shantou, Guangdong Province, China.|Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Shenzhen PKU-HKUST Medical Center, Institute of Urology, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Yu-Chi
authors: YC
authors: Li
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Zhi
authors: Z
authors: Cai
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Xue-Shuang
authors: XS
authors: Mei
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Peng
authors: P
authors: Yu
authors: Department of Clinical Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China.
authors: Li-Ping
authors: LP
authors: Nie
authors: Biomedical Research Institute, Shenzhen Peking University-the Hong Kong University of Science and Technology Medical Center, 518036, Shenzhen, Guangdong Province, China. zhangweispace@yeah.net.
authors: Wei
authors: W
authors: Zhang
authors: Central Laboratory, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China. dongboyaa@163.com.
authors: Zhen-Dong
authors: ZD
authors: Yu
authors: Department of Otolaryngological, Peking University Shenzhen Hospital, 518036, Shenzhen, Guangdong Province, China. nghui@21cn.com.
authors: Guo-Hui
authors: GH
authors: Nie
mesh_terms: D017209:Apoptosis / Q000235:genetics; D063646:Carcinogenesis / Q000235:genetics; D002277:Carcinoma; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: C547168:MIRN494 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; D017350:N-Acetylgalactosaminyltransferases; C400542:UDP-N-acetylgalactosamine--polypeptide N-acetylgalactosaminyltransferase 7; D018844:Cyclin-Dependent Kinases; C089463:PCTAIRE-1 protein kinase
keywords: CDK16; GALNT7; Nasopharyngeal carcinoma; Tumor suppressor; miR-494