title: Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia.
abstract: OBJECTIVE
  The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE).
  
  
  METHODS
  Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team.
  
  
  RESULTS
  There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group.
  
  
  CONCLUSIONS
  The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.
authors: a Department of Gynecology and Obstetrics , University Hospital Split, School of Medicine, University of Split , Split , Croatia .|b School of Medicine, University of Split , Split , Croatia , and.
authors: Sandra
authors: S
authors: Benzon
authors: b School of Medicine, University of Split , Split , Croatia , and.|c Institute for Pathology, University Hospital Split , Split , Croatia.
authors: Sandra
authors: S
authors: Zekić Tomaš
authors: a Department of Gynecology and Obstetrics , University Hospital Split, School of Medicine, University of Split , Split , Croatia .|b School of Medicine, University of Split , Split , Croatia , and.
authors: Zdeslav
authors: Z
authors: Benzon
authors: a Department of Gynecology and Obstetrics , University Hospital Split, School of Medicine, University of Split , Split , Croatia .|b School of Medicine, University of Split , Split , Croatia , and.
authors: Marko
authors: M
authors: Vulić
authors: b School of Medicine, University of Split , Split , Croatia , and.|c Institute for Pathology, University Hospital Split , Split , Croatia.
authors: Ivana
authors: I
authors: Kuzmić Prusac
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D010920:Placenta / Q000276:immunology* / Q000473:pathology; D010922:Placenta Diseases / Q000276:immunology* / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology* / Q000473:pathology; D011247:Pregnancy
keywords: Preeclampsia; T lymphocytes; villitis of unknown etiology