title: TNNI3K in cardiovascular disease and prospects for therapy.
abstract: Cardiovascular diseases are an important cause of morbidity and mortality worldwide and the global burden of these diseases continues to grow. Therefore new therapies are urgently needed. The role of protein kinases in disease, including cardiac disease, is long recognized, making kinases important therapeutic targets. We here review the knowledge gathered in the last decade about troponin I-interacting kinase (TNNI3K), a kinase with cardiac-restricted expression that has been implicated in various cardiac phenotypes and diseases including heart failure, cardiomyopathy, ischemia/reperfusion injury and conduction of the cardiac electrical impulse.
authors: Department of Clinical and Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors: Annalisa
authors: A
authors: Milano
authors: Department of Clinical and Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors: Elisabeth M
authors: EM
authors: Lodder
authors: Department of Clinical and Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands. Electronic address: C.R.Bezzina@amc.uva.nl.
authors: Connie R
authors: CR
authors: Bezzina
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D005786:Gene Expression Regulation; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017346:Protein Serine-Threonine Kinases; D021381:Protein Transport
chemical_list: D017346:Protein Serine-Threonine Kinases; C481078:TNNI3K protein, human; D020930:MAP Kinase Kinase Kinases
keywords: Arrhythmia; Heart failure; Ischemia/reperfusion; Kinase; Tnni3k