title: Evaluation of autoimmune thyroid disease in melasma.
abstract: Melasma is one of the most frequently acquired hyperpigmentation disorders clinically characterized by symmetrical brown patches on sun-exposed areas. To date, few studies have been conducted about the relationship between thyroid autoimmun-ity and melasma. To evaluate the thyroid dysfunction and autoimmunity in nonpregnant women with melasma. A total of 70 women with melasma and 70 age-matched healthy women with no history of melasma were enrolled in the study. We studied the thyroid hormone profile in both groups. The statistical analysis was performed using SPSS software. Patients with melasma had 18.5% frequency of thyroid disorders, and 15.7% had positive anti-TPO, while subjects from the control group had a 4.3% frequency of thyroid abnormalities, and only 5.7% had positive anti-TPO. There was a significantly higher prevalence of thyroid dysfunction in women with melasma compared with control group (P = 0.008). This study suggests that there is a relationship between thyroid autoimmunity and melasma. However, to make recommendations on screening for thyroid disease in patients with melasma, future research of good methodological quality is needed.
authors: Department of Dermatology, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
authors: Majid
authors: M
authors: Rostami Mogaddam
authors: Department of Internal Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
authors: Manouchehr
authors: M
authors: Iranparvar Alamdari
authors: The Persian Gulf Marine Medicine Biotechnology Research Center, Department of Endocrinology, Bushehr University of Medical Sciences, Bushehr, Iran.
authors: Nasrollah
authors: N
authors: Maleki
authors: Department of Midwifery, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
authors: Nastaran
authors: N
authors: Safavi Ardabili
authors: Department of Dermatology, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.
authors: Selma
authors: S
authors: Abedkouhi
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008548:Melanosis / Q000150:complications*; D008875:Middle Aged; D011446:Prospective Studies; D013959:Thyroid Diseases / Q000150:complications* / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood; D055815:Young Adult
chemical_list: D013963:Thyroid Hormones
keywords: autoimmunity; melasma; thyroid function test