title: The Kidney-Gut Axis: Implications for Nutrition Care.
abstract: There is increasing clinical evidence that patients with chronic kidney disease (CKD) have a distinctly dysbiotic intestinal bacterial community, termed the gut microbiota, which in turn drives a cascade of metabolic abnormalities, including uremic toxin production, inflammation, and immunosuppression, that ultimately promotes progressive kidney failure and cardiovascular disease. As the gut microbiota is intimately influenced by diet, the discovery of the kidney-gut axis has created new therapeutic opportunities for nutritional intervention. This review discusses the metabolic pathways linking dysbiotic gut microbiota with adverse health outcomes in patients with CKD, as well as novel therapeutic strategies for targeting these pathways involving dietary protein, fiber, prebiotics, probiotics, and synbiotics. These emerging nutritional interventions may ultimately lead to a paradigm shift in the conventional focus of dietary management in CKD.
authors: Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia; Translational Research Institute, Brisbane, Australia. Electronic address: megan.rossi@health.qld.gov.au.
authors: Megan
authors: M
authors: Rossi
authors: School of Medicine, University of Queensland, Brisbane, Australia; Translational Research Institute, Brisbane, Australia; Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia.
authors: David W
authors: DW
authors: Johnson
authors: Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Australia; Translational Research Institute, Brisbane, Australia; Faculty of Health Sciences and Medicine, Bond University, Robina, Australia.
authors: Katrina L
authors: KL
authors: Campbell
mesh_terms: D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000382:microbiology; D007249:Inflammation; D007668:Kidney / Q000378:metabolism* / Q000382:microbiology; D056692:Prebiotics / Q000008:administration & dosage; D019936:Probiotics / Q000008:administration & dosage; D051436:Renal Insufficiency, Chronic / Q000178:diet therapy / Q000382:microbiology; D058616:Synbiotics / Q000008:administration & dosage
chemical_list: D004043:Dietary Fiber; D004044:Dietary Proteins; D056692:Prebiotics