title: Comparison of Serum Zinc Levels among Children with Simple Febrile Seizure and Control Group: A Systematic Review.
abstract: OBJECTIVE
  Several factors are involved in the etiology of febrile seizure (FS), among them is zinc (Zn), which has been discussed in various studies. The present systematic review compares Zn levels in children with FS and a control group.
  
  
  METHODS
  We searched keywords of febrile seizure, febrile convulsion, children, childhood, fever, trace elements, risk factor, predisposing, zinc, Zn, and epilepsy in the following databases: SCOPUS, PubMed, and Google Scholar. The quality of research papers was assessed using a checklist. Data was extracted from primary studies based on demographic variables and amounts of Zn in case and control groups.
  
  
  RESULTS
  Twenty primary studies were entered in the present study. Of which, eighteen studies, reported that Zn serum levels were significantly lower in the case group (patients with FS) than the control group.
  
  
  CONCLUSIONS
  The present systematic review indicated that Zn is one factor for predicting FS. A low level of this element among children can be regarded as a contributing factor for FS, a conclusion with a high consensus among different studies carried out in different parts of the world.
authors: Pediatric Neurology Department, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Mohammad Mehdi
authors: MM
authors: Nasehi
authors: Faculty of health, Kerman University of Medical Sciences, Kerman, Iran.
authors: Roya
authors: R
authors: Sakhaei
authors: Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Mahmood
authors: M
authors: Moosazadeh
authors: Research Center for Health Services Management, Institute for Futures Studies in Health, Kerman University Of Medical Sciences, Kerman, Iran.
authors: Maryam
authors: M
authors: Aliramzany
keywords: Febrile convulsion; Febrile seizure; Systematic review; Trace elements; Zinc