title: Altered profile of gut microbiota after subchronic exposure to neochamaejasmin A in rats.
abstract: Neochamaejasmin A, isolated from Stellera chamaejasme L., has been widely used in China. Gut microbiota represent the first barrier against xenobiotics. This study aimed to evaluate the effects of subchronic exposure to neochamaejasmin A on the composition of gut microbiota. We found that neochamaejasmin A altered 21 OTUs in female rats and 46 OTUs in male rats. Among these OTUs, OTU86, OTU338 and OTU482 were shared in neochamaejasmin A-fed groups in both genders, implying that neochamaejasmin A might promote the growth of these three genera. In contrast, little or no effect on 226 OTUs was observed at all doses in both genders, suggesting their resistance to neochamaejasmin A. These findings could help improve our understanding of the health effects of neochamaejasmin A and provide an example of the risk assessment of pharmaceuticals or food contaminants on the gut microbiota composition.
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 211166, China.
authors: Lifeng
authors: L
authors: Yan
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 211166, China.
authors: Cheng
authors: C
authors: Xu
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 211166, China.
authors: Qian
authors: Q
authors: Liu
authors: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 211166, China; Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, 211166, China. Electronic address: aihuagu@njmu.edu.cn.
authors: Aihua
authors: A
authors: Gu
authors: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200025, China. Electronic address: zhaoyanjiang@gmail.com.
authors: Zhao-Yan
authors: ZY
authors: Jiang
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000235:genetics; D044946:Biflavonoids / Q000633:toxicity*; D003106:Colon / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D000069196:Gastrointestinal Microbiome / Q000187:drug effects*; D008297:Male; D010802:Phylogeny; D017207:Rats, Sprague-Dawley
chemical_list: D044946:Biflavonoids; C530231:neochamaejasmin A
keywords: Gut microbiota; Neochamaejasmin A; OTU338; OTU482; OTU86; Subchronic toxicity