title: Age changes of human serum polyreactive immunoglobulins (PRIG) activity.
abstract: It has been determined that activity of serum polyreactive immunoglobulins (PRIG) changes with age in practically healthy people at the age from twenty five to seventy. Therewith, the activity of serum IgG PRIG increases most of all (about 3-4 times), while IgM PRIG activity, on the contrary, does not increase, but sometimes even decreases with age. IgA PRIG activity varies significantly more than IgG PRIG activity and, besides, IgA PRIG significantly less depends on age than IgG PRIG. The age changes in the activity of human serum PRIG, belonging to different types of immunoglobulins, may evidence for the important functional role of these immunoglobulins that has to be clarified.
authors: S A
authors: SA
authors: Bobrovnik
authors: M A
authors: MA
authors: Demchenko
authors: S V
authors: SV
authors: Komisarenko
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000097:blood* / Q000276:immunology; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000737:chemistry*; D007074:Immunoglobulin G / Q000097:blood / Q000737:chemistry*; D007075:Immunoglobulin M / Q000097:blood / Q000737:chemistry*; D008297:Male; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012709:Serum Albumin