title: Milk proteins, peptides, and oligosaccharides: effects against the 21st century disorders.
abstract: Milk is the most complete food for mammals, as it supplies all the energy and nutrients needed for the proper growth and development of the neonate. Milk is a source of many bioactive components, which not only help meeting the nutritional requirements of the consumers, but also play a relevant role in preventing various disorders. Milk-derived proteins and peptides have the potential to act as coadjuvants in conventional therapies, addressing cardiovascular diseases, metabolic disorders, intestinal health, and chemopreventive properties. In addition to being a source of proteins and peptides, milk contains complex oligosaccharides that possess important functions related to the newborn's development and health. Some of the health benefits attributed to milk oligosaccharides include prebiotic probifidogenic effects, antiadherence of pathogenic bacteria, and immunomodulation. This review focuses on recent findings demonstrating the biological activities of milk peptides, proteins, and oligosaccharides towards the prevention of diseases of the 21st century. Processing challenges hindering large-scale production and commercialization of those bioactive compounds have been also addressed.
authors: Department of Human Development and Family Studies (Nutritional Science & Education), National Taiwan Normal University, No.162, Section 1, Heping East Road, Taipei 106, Taiwan.
authors: Chia-Chien
authors: CC
authors: Hsieh
authors: Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI UAM+CSIC), Nicolás Cabrera 9, 28049 Madrid, Spain.
authors: Blanca
authors: B
authors: Hernández-Ledesma
authors: Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM, CEI UAM+CSIC), Nicolás Cabrera 9, 28049 Madrid, Spain.
authors: Samuel
authors: S
authors: Fernández-Tomé
authors: Food Science Department, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors: Valerie
authors: V
authors: Weinborn
authors: Food Science Department, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors: Daniela
authors: D
authors: Barile
authors: Food Science Department, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA ; Foods for Health Institute, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
authors: Juliana María Leite Nobrega
authors: JM
authors: de Moura Bell
mesh_terms: D000818:Animals; D006262:Health; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008892:Milk / Q000378:metabolism*; D008894:Milk Proteins / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism
chemical_list: D008894:Milk Proteins; D009844:Oligosaccharides; D010455:Peptides