title: Hyperinsulinemia in newly diagnosed patients with multiple sclerosis.
abstract: There are limited data regarding glucose metabolism dysregulation in multiple sclerosis (MS). Present study investigates glucose and insulin response during oral glucose tolerance test (oGTT) in MS patients. We examined 19 MS patients and 19 age, sex and body mass index (BMI) matched healthy controls. MS patients were newly diagnosed, untreated and with low Expanded Disability Status Scale (EDSS) score (1.1 ± 0.7). Plasma glucose, lactate, insulin and GLP-1 during oGTT, and fasting adipokines, lipid and inflammatory parameters were analyzed. Insulin sensitivity indices (ISI) were calculated. MS patients had comparable fasting (5.2 ± 0.3 vs. 5.0 ± 0.4 mmol/l, p = 0.05) and post-load glucose concentrations as controls. Insulin response to oral glucose load in MS was increased (p = 0.022). Insulin sensitivity was lower in MS compared to controls [ISI(Matsuda) 6.95 ± 3.44 vs. 10.60 ± 4.81, p = 0.011 and ISI(Cederholm) 49.9 ± 15.3 vs. 61.3 ± 16.3, p = 0.032]. We did not find any difference in lactate, GLP-1, total, HDL and LDL cholesterol, triglycerides, interleukin 6, tumor necrosis factor, C-reactive protein, resistin, leptin, adiponectin levels between groups. We found decreased insulin sensitivity with postprandial hyperinsulinemia in MS patients, which seems not to be related to chronic inflammation or physical inactivity. The role of hyperinsulinemia in CNS function impairment should be further investigated.
authors: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
authors: Adela
authors: A
authors: Penesova
authors: Miroslav
authors: M
authors: Vlcek
authors: Richard
authors: R
authors: Imrich
authors: Lucia
authors: L
authors: Vernerova
authors: Andrea
authors: A
authors: Marko
authors: Milada
authors: M
authors: Meskova
authors: Lucia
authors: L
authors: Grunnerova
authors: Peter
authors: P
authors: Turcani
authors: Daniela
authors: D
authors: Jezova
authors: Branislav
authors: B
authors: Kollar
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin