title: Rapid Generation and Safe Use of Carbenes Enabled by a Novel Flow Protocol with In-line IR spectroscopy.
abstract: A powerful new continuous process for the formation and use of donor/acceptor-substituted carbenes is described. The safety profile of diazo group transfer on methyl phenylacetate was determined including kinetic studies in batch and in flow using in-line IR analysis. Batch work-up and liquid chromatography were circumvented by developing an optimized liquid/liquid flow separation method providing aryl diazoacetates in high purity. Fast screening of reaction conditions in flow with in-line IR analysis allowed rapid reaction optimization. Finally, a multistep process of diazo group transfer, extraction, separation and subsequent diazo decomposition combined with multiple X-H insertion reactions was established.
authors: School of Chemistry, Cardiff University, Park Place, Main Building, Cardiff CF10 3AT (UK) http://blogs.cardiff.ac.uk/wirth/
authors: Simon T R
authors: ST
authors: Müller
authors: Aurélien
authors: A
authors: Murat
authors: Delphine
authors: D
authors: Maillos
authors: Patrick
authors: P
authors: Lesimple
authors: Paul
authors: P
authors: Hellier
authors: Thomas
authors: T
authors: Wirth
keywords: IR spectroscopy; continuous flow; diazo compounds; in-line analysis; kinetics