title: Increased levels of soluble ST2 in patients with active newly diagnosed ANCA-associated vasculitis.
abstract: OBJECTIVE
  ST2, a member of the interleukin-1 receptor family, is selectively expressed on Th2 cells and mediates important Th2 functions. IL-33 is a specific ligand of ST2. The aim of the study was to determine whether serum levels of soluble ST2 (sST2) or IL-33 predict activity of the disease in patients with ANCA-associated vasculitides (AAV).
  
  
  METHODS
  139 AAV patients and 62 controls were studied. IL-33 and sST2 in the blood were measured with a commercially available ELISA.
  
  
  RESULTS
  Newly diagnosed AAV patients had higher sST2 levels than controls (P < 0.01). Levels of sST2 were significantly higher in active newly diagnosed AAV patients than in patients with remission (P < 0.001). IL-33 levels were higher in AAV patients than in the control groups (P = 0.002). However, serum IL-33 levels were not increased in patients with active AAV compared to patients in remission. IL-33 levels were higher in patients with granulomatosis with polyangiitis than in patients with microscopic polyangiitis (P = 0.012).
  
  
  CONCLUSIONS
  Serum sST2, but not serum IL-33, may be a marker of activity in AAV patients.
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: Z
authors: Z
authors: Hladinova
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic ; Institute of Immunology and Microbiology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: Z
authors: Z
authors: Hruskova
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: B
authors: B
authors: Svobodova
authors: Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: K
authors: K
authors: Malickova
authors: Statistical Unit, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
authors: V
authors: V
authors: Lanska
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: P
authors: P
authors: Konopásek
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: E
authors: E
authors: Jancova
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: R
authors: R
authors: Rysava
authors: Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO 800 45, USA.
authors: C L
authors: CL
authors: Edelstein
authors: Department of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
authors: V
authors: V
authors: Tesar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000276:immunology*; D005260:Female; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*
chemical_list: C079241:IL1RL1 protein, human; C506536:IL33 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D011956:Receptors, Cell Surface