title: Clinical aspects of indirect immunofluorescence for autoimmune diseases.
abstract: Because the most common term used in conversations considering autoimmunity is autoantibodies, it is well-expected that the indirect immunofluorescence assay, which detects antibodies directed against various antigens, is one of our most impressive techniques for investigating autoimmune diseases (AIDs). Roughly speaking, the current literature corroborates that this immunopathologic investigation means that autoantibodies detection makes a considerable contribution to both diagnostic and prognostic aspects of AIDs in the clinical setting. However, it varies between different AIDs, autoantibodies, ethnicities or detection methodologies. Directly focusing on the indirect immunofluorescence assay, we present evidence to support this multidimensional variation regarding the subject via reviewing briefly the best-investigated autoantibodies in the well-documented AIDs, including vasculitis, inflammatory bowel disease, scleroderma, autoimmune hepatitis, primary biliary cirrhosis, systemic lupus erythematosus and Sjögren's syndrome.
authors: Department of Pathology, Imam Khomeini Complex Hospital, School of Medicine, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Alireza
authors: A
authors: Ghanadan
authors: Amene
authors: A
authors: Saghazadeh
authors: Issa
authors: I
authors: Jahanzad
authors: Nima
authors: N
authors: Rezaei
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect / Q000379:methods* / Q000639:trends; D006801:Humans; D011379:Prognosis
chemical_list: D001323:Autoantibodies; D001324:Autoantigens
keywords: autoantibodies; autoimmune diseases; indirect immunofluorescence