title: Strategy use, planning, and rule acquisition deficits in spinocerebellar ataxia type 2 patients.
abstract: Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients.
authors: 1Laboratory of Neuropsychology,Department of Physiology, Faculty of Medicine,National Autonomous University of Mexico,Coyoacan,Mexico City 04510,Mexico City,Mexico.
authors: Israel
authors: I
authors: Vaca-Palomares
authors: 1Laboratory of Neuropsychology,Department of Physiology, Faculty of Medicine,National Autonomous University of Mexico,Coyoacan,Mexico City 04510,Mexico City,Mexico.
authors: Rosalinda
authors: R
authors: Díaz
authors: 2Centre for the Investigation and Rehabilitation of Hereditary Ataxias,Holguin,Cuba.
authors: Roberto
authors: R
authors: Rodríguez-Labrada
authors: 2Centre for the Investigation and Rehabilitation of Hereditary Ataxias,Holguin,Cuba.
authors: Jacqueline
authors: J
authors: Medrano-Montero
authors: 2Centre for the Investigation and Rehabilitation of Hereditary Ataxias,Holguin,Cuba.
authors: Raúl
authors: R
authors: Aguilera-Rodríguez
authors: 2Centre for the Investigation and Rehabilitation of Hereditary Ataxias,Holguin,Cuba.
authors: Yaimeé
authors: Y
authors: Vázquez-Mojena
authors: 1Laboratory of Neuropsychology,Department of Physiology, Faculty of Medicine,National Autonomous University of Mexico,Coyoacan,Mexico City 04510,Mexico City,Mexico.
authors: Juan
authors: J
authors: Fernandez-Ruiz
authors: 2Centre for the Investigation and Rehabilitation of Hereditary Ataxias,Holguin,Cuba.
authors: Luis
authors: L
authors: Velázquez-Pérez
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D042622:DNA Repeat Expansion / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D008609:Mental Status Schedule; D008875:Middle Aged; D009043:Motor Activity; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D020754:Spinocerebellar Ataxias / Q000150:complications* / Q000235:genetics; D055815:Young Adult
keywords: CANTAB