title: Penile cancer in a man with netherton syndrome.
abstract: Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS.
authors: Department of Urology, University of Minnesota, Minneapolis, MN.
authors: Sumit
authors: S
authors: Isharwal
authors: Department of Pathology and Laboratory Medicine, Minneapolis Veterans Affairs Medical Center, Minneapolis, MN.
authors: Juan Carlos
authors: JC
authors: Manivel
authors: Department of Urology, University of Minnesota, Minneapolis, MN. Electronic address: brkonety@umn.edu.
authors: Badrinath
authors: B
authors: Konety
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D056770:Netherton Syndrome / Q000150:complications*; D010412:Penile Neoplasms / Q000150:complications* / Q000473:pathology