title: Integrating clinical indexes into four-diagnostic information contributes to the Traditional Chinese Medicine (TCM) syndrome diagnosis of chronic hepatitis B.
abstract: Traditional Chinese Medicine (TCM) treatment has been commonly used to treat Chronic Hepatitis B (CHB) in Asian countries based on TCM syndrome diagnosis, also called "ZHENG". The syndrome is identified through the four-diagnostic methods, with certain degree of subjectivity and ambiguity from individual doctors. Normally those CHB patients also receive series of parameters from modern clinical examination, while they are routinely believed to be unrelated with the TCM syndrome diagnosis. In this study, we investigated whether these biomedical indexes in modern medicine could be beneficial to TCM syndrome diagnostics in an integrative way. Based on 634 patient samples from health controls and three subtypes of CHB syndromes, a two-view based hierarchical classification model was tested for TCM syndromes prediction based on totally 222 parameters integrated from both TCM practice and modern clinical tests. The results indicated that the performance of syndrome classification based on a proper integration of TCM and modern clinical indexes was significantly higher than those based on one view of parameters only. Furthermore, those indexes correlated with CHB syndrome diagnosis were successfully identified for CM indexes and biochemical indexes respectively, where potential associations between them were hinted to the MAPK signaling pathway.
authors: 1] School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China [2] School of Biomedical Informatics, University of Texas Health Science Center, Houston. TX 77030, USA.
authors: Hong
authors: H
authors: Kang
authors: Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R.China.
authors: Yu
authors: Y
authors: Zhao
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Chao
authors: C
authors: Li
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Yujia
authors: Y
authors: Chen
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Kailin
authors: K
authors: Tang
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Linlin
authors: L
authors: Yang
authors: Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R.China.
authors: Chao
authors: C
authors: Ma
authors: Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R.China.
authors: Jinghua
authors: J
authors: Peng
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Ruixin
authors: R
authors: Zhu
authors: School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China.
authors: Qi
authors: Q
authors: Liu
authors: 1] Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R.China [2] E-Institute of TCM Internal Medicine, Shanghai Municipal Education Commission, Shanghai 200003, P.R.China.
authors: Yiyang
authors: Y
authors: Hu
authors: 1] School of Life Sciences and Technology, Tongji University, Shanghai 200092, P.R.China [2] Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R.China.
authors: Zhiwei
authors: Z
authors: Cao
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D005786:Gene Expression Regulation; D006515:Hepatitis B virus / Q000235:genetics / Q000472:pathogenicity*; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D020935:MAP Kinase Signaling System; D008516:Medicine, Chinese Traditional / Q000379:methods*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D015233:Models, Statistical; D050791:STAT Transcription Factors / Q000235:genetics / Q000378:metabolism; D063189:Symptom Assessment / Q000706:statistics & numerical data*; D013577:Syndrome
chemical_list: D015415:Biomarkers; D050791:STAT Transcription Factors; D020928:Mitogen-Activated Protein Kinases