title: Isoniazid-induced acute liver failure during preventive therapy for latent tuberculosis infection.
abstract: Treating latent tuberculosis infection is a strategy for eliminating tuberculosis, and isoniazid is recommended as preventive therapy. However, concerns have been raised regarding the application of isoniazid due to its toxicity, particularly hepatotoxicity; however, biochemical monitoring is not routinely performed during treatment. We herein present a case of fatal isoniazid-induced acute liver failure. The patient's liver function was not periodically examined and isoniazid therapy was continued for 10 days despite the onset of symptoms associated with hepatitis. The patient died four months after hospitalization. It is essential to consider the potential toxicities of isoniazid and establish strategies to prevent acute liver failure.
authors: Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Japan.
authors: Shoichi
authors: S
authors: Miyazawa
authors: Shunichi
authors: S
authors: Matsuoka
authors: Suguru
authors: S
authors: Hamana
authors: Shintaro
authors: S
authors: Nagai
authors: Hitomi
authors: H
authors: Nakamura
authors: Kazushige
authors: K
authors: Nirei
authors: Mitsuhiko
authors: M
authors: Moriyama
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006760:Hospitalization; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects* / Q000627:therapeutic use; D055985:Latent Tuberculosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin