title: Environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the EGAT study.
abstract: Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.
authors: Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Jintana
authors: 0000-0002-5881-6884
authors: J
authors: Sirivarasai
authors: Cardiovascular and Metabolic Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Sukhumpun
authors: S
authors: Kaojarern
authors: Office of Research Academic and Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Suwannee
authors: S
authors: Chanprasertyothin
authors: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Pachara
authors: P
authors: Panpunuan
authors: Research and Development Institute, Kasetsart University, Bangkok 10900, Thailand.
authors: Krittaya
authors: K
authors: Petchpoung
authors: Health Office, Electricity Generating Authority of Thailand, Nonthaburi 11130, Thailand.
authors: Aninthita
authors: A
authors: Tatsaneeyapant
authors: Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
authors: Krongtong
authors: K
authors: Yoovathaworn
authors: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Thunyachai
authors: T
authors: Sura
authors: Occupational and Environmental Toxicology Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Sming
authors: S
authors: Kaojarern
authors: Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
authors: Piyamit
authors: P
authors: Sritara
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000235:genetics; D002374:Catalase / Q000097:blood / Q000235:genetics*; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D004912:Erythrocytes / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007854:Lead / Q000009:adverse effects* / Q000097:blood*; D015227:Lipid Peroxidation / Q000235:genetics; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007854:Lead; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione