title: Effects of hydrochlorothiazide on oxidative stress and pulse pressure in hypertensive patients with chronic stroke: the EMINENT study.
abstract: OBJECTIVE
  Thiazide diuretics are reported to have antioxidant effects and reduce pulse pressure (PP). The aim of this study was to elucidate whether hydrochlorothiazide additionally exerts such effects in stroke patients under treatment with losartan.
  
  
  METHODS
  This study was an open-label, randomized, multicenter study. Patients with a history of chronic stroke and treatment with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors for essential hypertension were enrolled. Fifty-five hypertensive patients were randomly assigned to two groups: those further treated with hydrochlorothiazide and those further treated with non-diuretic antihypertensive drugs.
  
  
  RESULTS
  Both groups showed a significant decrease in PP over six months (hydrochlorothiazide group: 67±12 mmHg to 58±12, p<0.001; non-diuretic group: 72±12 to 61±12, p<0.001), although no significant differences were observed between the two groups. The malondialdehyde-modified low-density lipoprotein levels did not change significantly after treatment in either group.
  
  
  CONCLUSIONS
  In this study, hydrochlorothiazide treatment did not provide any additional benefits over non-diuretic antihypertensive drugs in terms of antioxidant effects or reducing PP.
authors: Cerebrovascular and Neurology Center, Cerebrovascular Division, National Hospital Organization Fukuoka Higashi Medical Center, Japan.
authors: Hiroshi
authors: H
authors: Nakane
authors: Masahiro
authors: M
authors: Kamouchi
authors: Jun
authors: J
authors: Hata
authors: Setsuro
authors: S
authors: Ibayashi
authors: Kenji
authors: K
authors: Kusuda
authors: Tsuyoshi
authors: T
authors: Omae
authors: Tetsuhiko
authors: T
authors: Nagao
authors: Tetsuro
authors: T
authors: Ago
authors: Takanari
authors: T
authors: Kitazono
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D002908:Chronic Disease; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology*; D008077:Lipoproteins, LDL / Q000187:drug effects; D019808:Losartan / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D020521:Stroke / Q000453:epidemiology*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D006442:Glycated Hemoglobin; D006852:Hydrochlorothiazide; D008077:Lipoproteins, LDL; D019808:Losartan