title: [Role of single-nucleotide polymorphism C-1562т of the matrix metaloproteіnaza-9 gene in the development of leiomyoma in women with cervical pathology].
abstract: 108 women diagnosed with leiomyoma and 84 women without this disease (control group) were examined during the research. Was conducted a comparative analysis of the genotypes distribution between women with cervical pathology of different complexity. The results of the research showed, that there is no connection between the С-1562Т polymorphism of the MMP-9 gene and the progression of leiomyoma the course of which is accompanied by false erosion of the cervix (ectopias epithelium) (p>0,521). There is also was not found any connection between the SNP in women with leiomyoma, who undergo conical electrocauterizing excision treatment because of the dysplastic epithelial changes that are considered to be precancerous (p>0,280).
authors: I N
authors: IN
authors: Savchenko
authors: V Y
authors: VY
authors: Garbuzova
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000473:pathology; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9