title: Pilot Study of Exercise Therapy on Painful Diabetic Peripheral Neuropathy.
abstract: OBJECTIVE
  Painful diabetic peripheral neuropathy (DPN) is a common complication of diabetes. While the beneficial effect of exercise on diabetes is well established, its effect specifically on painful DPN has not been thoroughly explored. The objective of this pilot study was to examine the effect of aerobic exercise on pain in people with DPN.
  
  
  METHODS
  Fourteen sedentary individuals (mean age 57 ± 5.11 years) with painful DPN were enrolled in a 16-week, supervised aerobic exercise program. The Brief Pain Inventory-Diabetic Peripheral Neuropathy was used to assess pain intensity (worst, least, average, now) and pain interference with daily life (activity, mood, walk, normal work, relationship, sleep, enjoyment of life) pre intervention and postintervention. Body mass index (BMI), maximum oxygen uptake (VO2max ), hemoglobin A1c (HbA1c), and blood pressure were also measured preintervention and postintervention as secondary outcomes of interest.
  
  
  RESULTS
  Significant reductions in pain interference were observed with walking (4.93 ± 3.03 pre to 3.29 ± 2.89 post, P = 0.016), normal work (5.39 ± 3.32 pre to 3.79 ± 3.04 post, P = 0.032), relationship with others (3.96 ± 3.53 pre to 1.29 ± 1.27 post, P = 0.006), sleep (5.11 ± 3.04 pre to 3.5 ± 3.03 post, P = 0.02), and the overall pain interference (4.65 ± 2.70 pre to 2.97 ± 2.22 post, P = 0.013) following the intervention; however, there was no change in pain intensity. VO2max increased significantly postintervention (16.02 ± 3.84 ml/kg/min pre to 17.18 ± 4.19 ml/kg/min, P = 0.028), while BMI, HbA1c, and blood pressure remained unchanged.
  
  
  CONCLUSIONS
  These preliminary results suggest that perceived pain interference may be reduced following an aerobic exercise intervention among people with painful DPN, without a change in pain intensity. Further validation by a RCT is needed.
authors: Departments of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Min
authors: M
authors: Yoo
authors: Departments of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Linda J
authors: LJ
authors: D'Silva
authors: Departments of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Katherine
authors: K
authors: Martin
authors: Departments of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Neena K
authors: NK
authors: Sharma
authors: Departments of Neurology University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Mamatha
authors: M
authors: Pasnoor
authors: Family Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Joseph W
authors: JW
authors: LeMaster
authors: Departments of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 3051, Kansas City, Kansas, USA.
authors: Patricia M
authors: PM
authors: Kluding
mesh_terms: D000328:Adult; D000368:Aged; D015308:Anaerobic Threshold; D001794:Blood Pressure; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003929:Diabetic Neuropathies / Q000150:complications / Q000628:therapy*; D015444:Exercise; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D008875:Middle Aged; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D058748:Pain Perception; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000628:therapy*; D010865:Pilot Projects; D016896:Treatment Outcome; D016138:Walking
chemical_list: D006442:Glycated Hemoglobin
keywords: Diabetic Peripheral Neuropathy; Exercise; Pain; Pain Interference