title: Biocatalytic approaches applied to the synthesis of nucleoside prodrugs.
abstract: Nucleosides are valuable bioactive molecules, which display antiviral and antitumour activities. Diverse types of prodrugs are designed to enhance their therapeutic efficacy, however this strategy faces the troublesome selectivity issues of nucleoside chemistry. In this context, the aim of this review is to give an overview of the opportunities provided by biocatalytic procedures in the preparation of nucleoside prodrugs. The potential of biocatalysis in this research area will be presented through examples covering the different types of nucleoside prodrugs: nucleoside analogues as prodrugs, nucleoside lipophilic prodrugs and nucleoside hydrophilic prodrugs.
authors: Laboratorio de Biocatálisis y Biotransformaciones, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, 1876 Bernal, Buenos Aires, Argentina.
authors: Luis E
authors: LE
authors: Iglesias
authors: Laboratorio de Biocatálisis y Biotransformaciones, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, 1876 Bernal, Buenos Aires, Argentina.
authors: Elizabeth S
authors: ES
authors: Lewkowicz
authors: Biocatalysis Group, Delft University of Technology, Julianalaan 67, 2628 BC Delft, The Netherlands.
authors: Rosario
authors: R
authors: Medici
authors: Laboratorio de Biocatálisis y Biotransformaciones, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, 1876 Bernal, Buenos Aires, Argentina.
authors: Paola
authors: P
authors: Bianchi
authors: Laboratorio de Biocatálisis y Biotransformaciones, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, 1876 Bernal, Buenos Aires, Argentina; Laboratorio de Química de Ácidos Nucleicos, INGEBI-CONICET, Vuelta de Obligado 2490, 1428 Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: airibarren@unq.edu.ar.
authors: Adolfo M
authors: AM
authors: Iribarren
mesh_terms: D055162:Biocatalysis; D001709:Biotechnology; D009705:Nucleosides; D009711:Nucleotides; D011355:Prodrugs
chemical_list: D009705:Nucleosides; D009711:Nucleotides; D011355:Prodrugs
keywords: Biocatalysis; Chemoenzymatic synthesis; Nucleosides; Nucleotides; Prodrugs