title: Liver resection for non-colorectal, non-carcinoid, non-sarcoma metastases: a multicenter study.
abstract: BACKGROUND
  The role of liver resection for non-colorectal, non-neuroendocrine, non-sarcoma (NCNNNS) metastases is ill-defined. This study aimed to examine the oncologic outcomes of liver resection in such patients.
  
  
  METHODS
  A retrospective analysis of liver resection for NCNNNS metastases was performed at two large centers. Liver resection was offered selectively in patients with stable disease. Oncologic outcomes were examined using the Kaplan-Meier method.
  
  
  RESULTS
  Fifty-two patients underwent liver resection for NCNNNS metastases. Overall 5-year survival was 58%. Five-year survival was 85% for breast metastases, 66% for ocular melanoma, 83% for other melanomas, 50% for gastro-esophageal metastases, and 0% for renal cell carcinoma metastases. A contemporary colorectal liver metastasis cohort had a survival of 63% (p=0.89).
  
  
  CONCLUSIONS
  Liver resection is an effective option in the management of selected patients with NCNNNS metastases which have been deemed stable. Five-year survival rates were comparable to that of a contemporary cohort of patients with colorectal liver metastases in carefully selected patients. Further, larger studies are required to help identify potential prognostic variables and aid in decision-making in this heterogeneous population.
authors: Ottawa Hospital Research Institute and Liver and Pancreas Surgery Unit, Division of General Surgery, University of Ottawa, Ottawa, ON, Canada.
authors: Guillaume
authors: G
authors: Martel
authors: Hepatobiliary Surgery, Division of General Surgery, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
authors: Jeff
authors: J
authors: Hawel
authors: Ottawa Hospital Research Institute and Liver and Pancreas Surgery Unit, Division of General Surgery, University of Ottawa, Ottawa, ON, Canada.
authors: Janelle
authors: J
authors: Rekman
authors: Hepatobiliary Surgery, Division of General Surgery, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
authors: Kristopher P
authors: KP
authors: Croome
authors: Hepatobiliary Surgery, Division of General Surgery, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
authors: Kimberly
authors: K
authors: Bertens
authors: Ottawa Hospital Research Institute and Liver and Pancreas Surgery Unit, Division of General Surgery, University of Ottawa, Ottawa, ON, Canada.
authors: Fady K
authors: FK
authors: Balaa
authors: Hepatobiliary Surgery, Division of General Surgery, London Health Sciences Centre, University of Western Ontario, London, ON, Canada.
authors: Roberto
authors: R
authors: Hernandez-Alejandro
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006498:Hepatectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008545:Melanoma / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome