title: Coadministration of HMG-CoA reductase inhibitors, atorvastatin and rosuvastatin, does not affect contraceptive efficacy of centchroman.
abstract: OBJECTIVE
  The study aimed to investigate the effect of concomitant use of atorvastatin or rosuvastatin on the pharmacokinetic and pharmacodynamic profile of centchroman, a non-steroidal female oral contraceptive.
  
  
  METHODS
  A rat model was used to predict pharmacokinetic drug-drug interactions between centchroman and atorvastatin or rosuvastatin. A dried blood spot sampling technique followed by liquid chromatography-tandem mass spectrometry detection was employed for analysis of the pharmacokinetic interaction study samples. Sperm-positive female rats were investigated for postcoital contraceptive activity of centchroman with or without coadministration of atorvastatin or rosuvastatin.
  
  
  RESULTS
  Coadministration of atorvastatin or rosuvastatin may increase the systemic availability of centchroman in blood, but it does not affect the pharmacodynamic profile of centchroman.
  
  
  CONCLUSIONS
  Atorvastatin or rosuvastatin may be prescribed with centchroman without compromising the contraceptive efficacy of centchroman.
authors: * Pharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute , Lucknow , India.
authors: Abhisheak
authors: A
authors: Sharma
authors: Swati
authors: S
authors: Jaiswal
authors: Mahendra
authors: M
authors: Shukla
authors: Kondagudur
authors: K
authors: Ravindrachary
authors: Jawahar
authors: J
authors: Lal
mesh_terms: D000818:Animals; D000069059:Atorvastatin / Q000008:administration & dosage / Q000494:pharmacology*; D002486:Centchroman / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D003276:Contraceptives, Oral / Q000008:administration & dosage; D003283:Contraceptives, Postcoital, Synthetic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000068718:Rosuvastatin Calcium / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D003276:Contraceptives, Oral; D003283:Contraceptives, Postcoital, Synthetic; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002486:Centchroman; D000068718:Rosuvastatin Calcium; D000069059:Atorvastatin
keywords: Dried blood spot; Drug interaction; Liquid chromatography–tandem mass spectrometry; Ormeloxifene