title: Primary mandibular xanthoma: case report.
abstract: Xanthoma is a very rare bone tumor, especially in the mandible, that can be associated with metabolic diseases such as hyperlipidemia. A 14-year-old girl presented with a non-corticated unilocular radiolucent lesion observed on panoramic radiography. The lesion was located between the roots of the left first and second premolar teeth, extending from the cervical to the apical region, measuring approximately 1 cm in greatest dimension. An excisional biopsy revealed foam cells and occasional nonfoamy mononuclear macrophage-like cells spread among a discrete fibrous stroma. Immunohistochemically, the xanthomatous cells were CD68 and vimentin positive, focally positive for S100, CD1a, and CD3 and negative for AE1/AE3, CD20, CD117, and HMB45. Hematologic and biochemical investigations ruled out systemic disease.
authors: Professor of the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil. Electronic address: Melissararaujo@hotmail.com.
authors: Melissa Rodrigues
authors: MR
authors: de Araujo
authors: Professor of the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil.
authors: Rafaela
authors: R
authors: Scariot
authors: MSc student at the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil.
authors: Lucas
authors: L
authors: Uetanabaro
authors: Histopathology Physician, Citopar, Centro de Citologia e Patologia Paraná, Paraná, Brazil.
authors: Larissa
authors: L
authors: Luvison Gomes da Silva
authors: Professor of the Graduate Program in Clinical Dentistry, Positivo University, Paraná, Brazil.
authors: Allan Fernando
authors: AF
authors: Giovanini
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008336:Mandibular Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D009971:Orthodontics, Corrective; D011862:Radiography, Panoramic; D014973:Xanthomatosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*
chemical_list: D015415:Biomarkers