title: Treatment of refractory Crohn's disease and pyoderma gangrenosum with a combination regimen of rifaximin, gentamicin and metronidazole.
abstract: The etiology of Crohn's disease (CD) remains controversial. It is hypothesized that CD is the result of an abnormal immune response to the gut flora in genetically susceptible hosts. However, an infectious etiology has not been completely ruled out. Antibiotics have been utilized with some success to modify the course of the disease. Here, we report a patient with CD and pyoderma gangrenosum refractory to standard therapy, including biologics, who achieved remission with a combination of rifaximin, gentamicin and metronidazole.
authors: St. Joseph Medical Center, The University of Maryland, Towson, Md., USA.
authors: Neil D
authors: ND
authors: Goldberg
authors: The Johns Hopkins Medical Institutions, Baltimore, Md., USA.
authors: Aravinda
authors: A
authors: Vadlamudi
authors: The Johns Hopkins Medical Institutions, Baltimore, Md., USA.
authors: Nicole
authors: N
authors: Parrish
keywords: Combination therapy; Crohn's disease; Pyoderma gangrenosum