title: Long-term outcomes of laparoscopic versus open liver resection for liver metastases from colorectal cancer: A comparative analysis of 168 consecutive cases at a single center.
abstract: BACKGROUND
  Laparoscopic liver resection for liver metastases from colorectal cancer (CRLM) is performed in a relatively small number of institutions. Its operative results have been reported to be comparable with that of open laparotomy; however, information on its oncologic outcomes is scarce. This study aimed to compare the long-term outcomes of laparoscopic hepatectomy (LH) and open hepatectomy (OH) to treat CRLM at a single institution.
  
  
  METHODS
  We retrospectively reviewed data from 168 consecutive patients who underwent LH (n = 100) or OH (n = 68) for CRLM. The tumor characteristics, operative results, overall survival (OS) rate, recurrence-free survival (RFS) rate, and recurrence patterns were analyzed and compared. A previously published survival-predicting nomogram was applied to compare OS and RFS between the 2 patient groups.
  
  
  RESULTS
  The largest tumor diameter and the number of tumors were significantly larger in the OH group than in the LH group; however, no differences in other tumor factors were observed between the 2 groups. When matched by the nomogram, OS and RFS remained comparable between the 2 groups in every examined stratum, not only for low-risk patients but also for those with high risk. The recurrence patterns also were similar (liver: 30.2% vs 26.8%, P = .72; lung: 22.6% vs 34.1%, P = .22; peritoneum: 7.6% vs 4.9%, P = .45).
  
  
  CONCLUSIONS
  The long-term outcomes of laparoscopic liver resection for CRLM were comparable with those of the open procedure in not only low-risk but also high-risk patients.
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan. Electronic address: hasegawayas@yahoo.co.jp.
authors: Yasushi
authors: Y
authors: Hasegawa
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Hiroyuki
authors: H
authors: Nitta
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Akira
authors: A
authors: Sasaki
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Takeshi
authors: T
authors: Takahara
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Hidenori
authors: H
authors: Itabashi
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Hirokatsu
authors: H
authors: Katagiri
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Koki
authors: K
authors: Otsuka
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Satoshi
authors: S
authors: Nishizuka
authors: Department of Surgery, Iwate Medical University School of Medicine, Morioka City, Iwate, Japan.
authors: Go
authors: G
authors: Wakabayashi
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D007564:Japan; D053208:Kaplan-Meier Estimate; D010535:Laparoscopy / Q000379:methods / Q000401:mortality*; D007813:Laparotomy / Q000379:methods / Q000401:mortality*; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D017741:Survivors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult