title: A systematic review and meta-analysis of longitudinal hippocampal atrophy in healthy human ageing.
abstract: BACKGROUND
  This review aimed to produce hippocampal atrophy rate estimates from healthy ageing studies as well as control samples from observational studies across the adult lifespan which can be used as benchmarks to evaluate abnormal changes in pathological conditions.
  
  
  METHODS
  The review followed PRISMA guidelines. PUBMED (to February 2014) was searched for longitudinal MRI studies reporting hippocampal atrophy or volume change in cognitively healthy individuals. Titles were screened and non-English, duplicate or irrelevant entries were excluded. Remaining record abstracts were reviewed to identify studies for full text retrieval. Full text was retrieved and screened against inclusion/exclusion criteria. Bibliographies and previous reviews were examined to identify additional studies. Data were summarised using meta-analysis and age, segmentation technique and study type were tested as potential moderators using meta-regression. It was hypothesised that population studies would produce higher atrophy rates than clinical observational studies.
  
  
  RESULTS
  The systematic search identified 4410 entries and 119 studies were retrieved with 58 failing selection or quality criteria, 30 were excluded as multiple reports and 3 studies were unsuitable for meta-analysis. The remaining 28 studies were included in the meta-analysis, n=3422, 44.65% male, 11,735 person-years of follow-up, mean age was 24.50 to 83 years. Mean total hippocampal atrophy for the entire sample was 0.85% per year (95% CI 0.63, 1.07). Age based atrophy rates were 0.38% per year (CI 0.14, 0.62) for studies with mean age <55 years (n=413), 0.98% (CI 0.27, 1.70) for 55 to <70 years (n=426), and 1.12% (CI 0.86, 1.38) for ≥70 years (n=2583). Meta-regression indicated age was associated with increased atrophy rates of 0.0263% (CI 0.0146, 0.0379) per year and automated segmentation approaches were associated with a reduced atrophy rate of -0.466% (CI -0.841, -0.090). Population studies were not associated with a significant effect on atrophy. Analyses of 11 studies separately measuring left and right hippocampal atrophy (n=1142) provided little evidence of laterality effects. While no study separately reported atrophy by gender, a number tested for gender effects and 2 studies reported higher atrophy in males.
  
  
  CONCLUSIONS
  Hippocampal atrophy rates increase with age with the largest increases occurring from midlife onwards. Manual segmentation approaches result in higher measured atrophy rates.
authors: Centre for Research on Ageing, Health and Wellbeing, Florey, Building 54, Mills Road, Australian National University, Canberra, ACT 2601, Australia. Electronic address: mark.fraser@anu.edu.au.
authors: Mark A
authors: MA
authors: Fraser
authors: Centre for Research on Ageing, Health and Wellbeing, Florey, Building 54, Mills Road, Australian National University, Canberra, ACT 2601, Australia.
authors: Marnie E
authors: ME
authors: Shaw
authors: Centre for Research on Ageing, Health and Wellbeing, Florey, Building 54, Mills Road, Australian National University, Canberra, ACT 2601, Australia.
authors: Nicolas
authors: N
authors: Cherbuin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001284:Atrophy; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D055815:Young Adult
keywords: Ageing; Controls; Epidemiology; Hippocampus; Longitudinal; MRI