title: Association of serum cytokines with colorectal polyp number and type in adult males.
abstract: Chronic inflammation contributes to colorectal carcinogenesis. To determine whether serum cytokines are associated with colon polyps, 126 asymptomatic men (48-65 years) were recruited during colonoscopy. Serum cytokine concentrations were measured. Odds ratios were determined using polytomous logistic regression for polyp number and type. Men with serum monocyte chemotactic protein-3 (MCP-3) or soluble interleukin-4 receptor (sIL-4R) concentrations in the highest tertile were 0.2 times less likely to have three or more polyps relative to no polyps. For each increase in serum MCP-3 or sIL-4R tertile a man was about 0.4 times less likely to have three or more polyps than to have no polyps. Men with serum concentrations of interferon-α2 (IFN-α2) or interleukin (IL)-7 in the highest tertile were three times more likely to have an adenoma than no polyps. Those with serum IL-8 concentrations in the highest tertile were four times more likely to have an adenoma than no polyps. For each increase in serum IFN-α2, IL-7, or IL-8 tertile an individual was 1.8 times more likely to have an adenoma than to have no polyps. Serum concentrations of MCP-3, sIL-4R, IFN-α2, IL-7, and IL-8 may indicate which men are more likely to have colorectal polyps.
authors: aDepartment of Food Science and Human Nutrition bCollege of Osteopathic Medicine cDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing dTri-County Gastroenterology, Charter Township of Clinton, Michigan, USA.
authors: Sarah S
authors: SS
authors: Comstock
authors: Diana
authors: D
authors: Xu
authors: Kari
authors: K
authors: Hortos
authors: Bruce
authors: B
authors: Kovan
authors: Sarah
authors: S
authors: McCaskey
authors: Dorothy R
authors: DR
authors: Pathak
authors: Jenifer I
authors: JI
authors: Fenton
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000097:blood / Q000175:diagnosis*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis*; D016207:Cytokines / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D016207:Cytokines