title: Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.
abstract: Circadian disruption has become a significant factor contributing to the epidemics of obesity and insulin resistance. However, interventions to treat metabolic dysfunctions induced by circadian disruptions are limited. The ovarian hormone, estrogen, produces important antiobesity and antidiabetic effects in female animals and has profound effects on daily behavioral rhythms. Here, we show that in female mice depleted with endogenous estrogens, a jet-lag paradigm induced visceral fat accumulation and systemic insulin resistance, which were associated with altered expression of multiple circadian genes in the visceral fat depot. Interestingly, all these jet-lag-induced deficits were completely rescued in female mice supplemented with exogenous estrogens. We further examined 24-hour oscillations of circadian genes in adipose tissues in female mice with estrogen depletion or replacement and showed that expression levels of the circadian gene, period circadian protein homolog 2, oscillate in visceral adipose tissue in an estrogen-dependent manner. Together, our results indicate that estrogens interact with the intrinsic circadian clock in adipose tissue and prevent abnormal lipid accumulation caused by circadian disruptions.
authors: Children's Nutrition Research Center (L.Z., F.Z., Y.Y., P.X., K.S., A.O.H., X.Y., H.D., Q.W., M.F., Y.X.), Department of Pediatrics; Diabetes Research Center (Z.S.), Department of Medicine; and Department of Molecular and Cellular Biology (Z.S., Y.X.), Baylor College of Medicine; and Brown Foundation Institute of Molecular Medicine (Q.T.), University of Texas Health Science Center at Houston, Houston, Texas 77030; and Department of Gastroenterology (L.Z.), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People's Republic of China.
authors: Liangru
authors: L
authors: Zhu
authors: Fang
authors: F
authors: Zou
authors: Yongjie
authors: Y
authors: Yang
authors: Pingwen
authors: P
authors: Xu
authors: Kenji
authors: K
authors: Saito
authors: Antentor
authors: A
authors: Othrell Hinton
authors: Xiaofeng
authors: X
authors: Yan
authors: Hongfang
authors: H
authors: Ding
authors: Qi
authors: Q
authors: Wu
authors: Makoto
authors: M
authors: Fukuda
authors: Zheng
authors: Z
authors: Sun
authors: Qingchun
authors: Q
authors: Tong
authors: Yong
authors: Y
authors: Xu
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D004967:Estrogens