title: Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK.
abstract: To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and renal thrombotic microangiopathy (TMA) was histopathologically confirmed. The medical records of dogs with skin lesions and AKI, with histopathologically confirmed renal TMA, were retrospectively reviewed. Thirty dogs from across the UK were identified with clinicopathological findings compatible with CRGV. These findings included the following: skin lesions, predominantly affecting the distal extremities; AKI; and variably, anaemia, thrombocytopaenia and hyperbilirubinaemia. Known causes of AKI were excluded. The major renal histopathological finding was TMA. All thirty dogs died or were euthanised. Shiga toxin was not identified in the kidneys of affected dogs. Escherichia coli genes encoding shiga toxin were not identified in faeces from affected dogs. CRGV has previously been reported in greyhounds in the USA, a greyhound in the UK, without renal involvement, and a Great Dane in Germany. This is the first report of a series of non-greyhound dogs with CRGV and AKI in the UK. CRGV is a disease of unknown aetiology carrying a poor prognosis when azotaemia develops.
authors: Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.
authors: L P
authors: http://orcid.org/0000-0002-3426-160X
authors: LP
authors: Holm
authors: Bridge Pathology, Horner Court, 637 Gloucester Road, Horfield, Bristol BS7 0BJ, UK.
authors: I
authors: I
authors: Hawkins
authors: Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.
authors: C
authors: C
authors: Robin
authors: Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK.
authors: R J
authors: RJ
authors: Newton
authors: Department of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
authors: R
authors: R
authors: Jepson
authors: Department of Clinical Science and Services, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK.
authors: G
authors: G
authors: Stanzani
authors: Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.
authors: L A
authors: LA
authors: McMahon
authors: Department of PMI, University of California, Davis, School of Veterinary Medicine, 4206 VM3A, 1 Shields Avenue, Davis, California 95616, USA.
authors: P
authors: P
authors: Pesavento
authors: Martin and Carr, The Old Well, Station Road, Pershore, Worcestershire WR10 2DB, UK.
authors: T
authors: T
authors: Carr
authors: School of Veterinary Sciences, University of Bristol, Langford, Bristol BS40 5DU, UK.
authors: T
authors: T
authors: Cogan
authors: Couto Veterinary Consultants, Hilliard, Ohio 43026, USA.
authors: C G
authors: CG
authors: Couto
authors: International Veterinary Renal Pathology Service, Department of Veterinary Biosciences, The Ohio State University, 301 Goss Laboratory, 1925 Coffey Rd, Columbus, Ohio, USA.
authors: R
authors: R
authors: Cianciolo
authors: Anderson Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire SO21 2LL, UK.
authors: D J
authors: DJ
authors: Walker
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D012883:Skin Ulcer / Q000150:complications / Q000662:veterinary*; D006113:United Kingdom; D014652:Vascular Diseases / Q000150:complications / Q000662:veterinary*
keywords: Dermatopathology; Histopathology; Internal medicine; Kidneys; Renal disease; Skin