title: Characterization of Carbapenemases in Extensively Drug Resistance Acinetobacter baumannii in a Burn Care Center in Iran.
abstract: The emergence of multidrug resistance (MDR) and extensively drug resistance (XDR) in Acinetobacter baumannii has made an important challenge in the treatment of infections caused by this organism. The ability of carbapenemase production is one of the main mechanisms for the emergence of MDR and/or XDR in A. baumannii. The aim of this study was to detect carbapenemase producer A. baumannii. In this study, 65 imipenem resistant A. baumannii were collected from burned patients. Biochemical identification, antibiotic susceptibility test and multiplex polymerase chain reactions for the detection of carbapenemases genes were performed. The results showed that all strains carried bla OXA-51. 83%, 12.5% and 9.23% strains harbored bla OXA-23, bla VIM and bla KPC genes, respectively. None of the isolates carried bla IMP, bla OXA-48, blaNDM-1 and bla SPM-1 genes. The results of this study indicate the emergence of Klebsiella pneumoniae Carbapenemase (KPC) in A. baumannii causing nosocomial infections in burned patients which can be important for hospital infection prevention systems in Iran.
authors: Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran. ; Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran.
authors: Leila
authors: L
authors: Azimi
authors: Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran.
authors: Malihe
authors: M
authors: Talebi
authors: Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
authors: Mohammad-Reza
authors: MR
authors: Pourshafie
authors: Molecular Microbiology Research Center, Shahed University, Tehran, Iran.
authors: Parviz
authors: P
authors: Owlia
authors: Antimicrobial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran. ; Department of Microbiology, Iran University of Medical Sciences, Tehran, Iran.
authors: Abdolaziz
authors: A
authors: Rastegar Lari
keywords: Acinetobacter baumannii; KPC; carbapenemases