title: To cipro or not to cipro: bilateral achilles ruptures with the use of quinolones.
abstract: Ciprofloxacin and other fluoroquinolones are commonly used broad-spectrum antimicrobial agents for treating bacterial infections. This class of antibiotic drugs has uncommon adverse effects that include tendonitis, tendon ruptures, and other tendon abnormalities. We describe a patient with spontaneous bilateral complete Achilles tendon rupture after ciprofloxacin treatment. Surgical repair was performed successfully, and the patient completed physical rehabilitation without incident. Care should be exercised when selecting pharmaceutical agents to maintain a positive benefit-to-risk balance.
authors: Jay
authors: J
authors: Seidel
authors: Terry
authors: T
authors: Clarke
authors: Bindu
authors: B
authors: Mathew
mesh_terms: D000125:Achilles Tendon / Q000000981:diagnostic imaging / Q000293:injuries*; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000627:therapeutic use*; D065609:Cytochrome P-450 CYP1A2 Inhibitors / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015363:Quinolones; D012421:Rupture; D013708:Tendon Injuries / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D065609:Cytochrome P-450 CYP1A2 Inhibitors; D015363:Quinolones; D002939:Ciprofloxacin