title: β-3AR W64R Polymorphism and 30-Minute Post-Challenge Plasma Glucose Levels in Obese Children.
abstract: OBJECTIVE
  In this study, we aimed to investigate the association of W64R polymorphism of the β3-adrenergic receptor gene (β-3AR) with childhood obesity and related pathologies.
  
  
  METHODS
  β-3AR gene W64R genotyping was carried out in 251 children aged 6-18 years. Of these subjects, 130 were obese (62 boys) and 121 were normal-weight (53 boys). In the obese group, fasting lipids, glucose and insulin levels were measured. Oral glucose tolerance test (OGTT) was performed in 75 of the obese patients.
  
  
  RESULTS
  The frequency of W64R genotype was similar in obese and non-obese children. In obese children, relative body mass index, waist-to-hip ratio, serum lipid, glucose and insulin levels, as well as homeostasis model assessment of insulin resistance (HOMA-IR) scores were not different between Arg allele carriers (W64R and R64R) and noncarriers (W64W). In 75 obese children, OGTT results showed that Arg allele carriers had significantly higher 30-minute glucose levels (p=0.027).
  
  
  CONCLUSIONS
  W64R polymorphism of the β-3AR gene is not associated with obesity and waist-to-hip ratio in Turkish children. Although there were no relationships between the genotypes and lipid, glucose/insulin levels or HOMA-IR, the presence of W64R variant seemed to have an unfavorable influence on early glucose excursion after glucose loading.
authors: Başkent University Faculty of Medicine, Department of Pediatric Endocrinology, Ankara, Turkey. E-mail: stkinik@gmail.com.
authors: Hasibe
authors: H
authors: Verdi
authors: Sibel
authors: S
authors: Tulgar Kınık
authors: Yaprak
authors: Y
authors: Yılmaz Yalçın
authors: Nursel
authors: N
authors: Muratoğlu Şahin
authors: Ayşe Canan
authors: AC
authors: Yazıcı
authors: F Belgin
authors: FB
authors: Ataç
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008055:Lipids / Q000032:analysis; D008297:Male; D009765:Obesity / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D022702:Receptors, Adrenergic, beta-3