title: Structural orientation dependent sub-lamellar bone mechanics.
abstract: The lamellar unit is a critical component in defining the overall mechanical properties of bone. In this paper, micro-beams of bone with dimensions comparable to the lamellar unit were fabricated using focused ion beam (FIB) microscopy and mechanically tested in bending to failure using atomic force microscopy (AFM). A variation in the mechanical properties, including elastic modulus, strength and work to fracture of the micro-beams was observed and related to the collagen fibril orientation inferred from back-scattered scanning electron microscopy (SEM) imaging. Established mechanical models were further applied to describe the relationship between collagen fibril orientation and mechanical behaviour of the lamellar unit. Our results highlight the ability to measure mechanical properties of discrete bone volumes directly and correlate with structural orientation of collagen fibrils.
authors: Department of Materials, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK.
authors: Ines
authors: I
authors: Jimenez-Palomar
authors: Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Israel.
authors: Anna
authors: A
authors: Shipov
authors: Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Israel.
authors: Ron
authors: R
authors: Shahar
authors: Department of Materials, School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK; School of Engineering, University of Portsmouth, Portsmouth PO1 3DJ, UK. Electronic address: asa.barber@port.ac.uk.
authors: Asa H
authors: AH
authors: Barber
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D019544:Equipment Failure Analysis; D005269:Femur; D055595:Mechanical Phenomena; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical
keywords: AFM; Bone; FIB; Micromechanics