title: No-carrier-added labeling of the neuroprotective Ebselen with selenium-73 and selenium-75.
abstract: Selenium-73 is a positron emitting non-standard radionuclide, which is suitable for positron emission tomography. A copper-catalyzed reaction allowed no-carrier-added labeling of the anti-inflammatory seleno-organic compound Ebselen with (73) Se and (75) Se under addition of sulfur carrier in a one-step reaction. The new authentically labeled radioselenium molecule is thus available for preclinical evaluation and positron emission tomography studies.
authors: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich, 52425 Jülich, Germany.
authors: Andreas
authors: A
authors: Helfer
authors: Johannes
authors: J
authors: Ermert
authors: Sven
authors: S
authors: Humpert
authors: Heinz H
authors: HH
authors: Coenen
mesh_terms: D001393:Azoles / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D054833:Isoindoles; D007553:Isotope Labeling; D008094:Lithium / Q000737:chemistry; D018696:Neuroprotective Agents / Q000737:chemistry*; D016566:Organoselenium Compounds / Q000737:chemistry*; D011854:Radiochemistry; D012644:Selenium Radioisotopes / Q000737:chemistry*
chemical_list: D001393:Azoles; D054833:Isoindoles; D018696:Neuroprotective Agents; D016566:Organoselenium Compounds; D012644:Selenium Radioisotopes; C042986:ebselen; D003300:Copper; D008094:Lithium
keywords: Ebselen; n.c.a. labeling; positron emission tomography; radioselenium