title: Targeting the canonical Wnt/β-catenin pathway in hematological malignancies.
abstract: The canonical Wnt/β-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/β-catenin pathway, β-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/β-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening. In this review, the significance of the canonical Wnt/β-catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.
authors: Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan.
authors: Eishi
authors: E
authors: Ashihara
authors: Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan.
authors: Tetsuya
authors: T
authors: Takada
authors: Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan.
authors: Taira
authors: T
authors: Maekawa
mesh_terms: D001853:Bone Marrow / Q000502:physiology; D044127:Epigenesis, Genetic; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics; D006801:Humans; D014411:Neoplastic Stem Cells / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000187:drug effects* / Q000502:physiology; D051176:beta Catenin / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D051176:beta Catenin
keywords: canonical Wnt pathway; hematological malignancies; high-throughput screening; small molecule inhibitors; β-Catenin