title: Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines.
abstract: The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2](2-) (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.
authors: Theranostic Nanomedicine Laboratory, CIC biomaGUNE, Paseo Miramón 182, 20009, San Sebastián, Euskadi, Spain. jmareque@cicbiomagune.es.
authors: A
authors: A
authors: Garaikoetxea Arguinzoniz
authors: N
authors: N
authors: Gómez Blanco
authors: P
authors: P
authors: Ansorena Legarra
authors: J C
authors: JC
authors: Mareque-Rivas
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity; D008970:Molecular Weight; D010084:Oxidation-Reduction; D010984:Platinum / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry* / Q000633:toxicity
chemical_list: D056831:Coordination Complexes; D011355:Prodrugs; D010984:Platinum; D006046:Gold; D011094:Polyethyleneimine