title: [Mitomycin in the complex treatment of strictures of vesicourethral anastomosis after radical prostatectomy].
abstract: The study involved 189 patients aged 40 to 80 years, which underwent retropubic radical prostatectomy for localized prostate cancer in the period from 2009 to 2013. 26 (13.8%) patients required repeated surgery due to the deterioration of urination. In primary detection or recurrent nature of the cicatrical process in vesico-urethral anastomosis, in places of dissection by urethrotomic knife (or transurethral resection), surgery was complemented by submucosal injection of mitomycin, previously diluted in saline to a concentration of not more than 0.2 mg/ml. Effectiveness of additional interstitial administration of mitomycin in primary application was 85%. Systemic infusion reactions have not been reported, that allows to consider this method as safe method for prevention of cicatricial complications.
authors: A V
authors: AV
authors: Artemov
authors: Iu G
authors: IuG
authors: Aliaev
authors: L M
authors: LM
authors: Rapoport
authors: D G
authors: DG
authors: Tsarichenko
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects; D003251:Constriction, Pathologic / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011468:Prostatectomy / Q000009:adverse effects*; D016896:Treatment Outcome; D014525:Urethral Stricture / Q000188:drug therapy* / Q000209:etiology*; D014554:Urination / Q000187:drug effects*
chemical_list: D016685:Mitomycin