title: Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
abstract: Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality. Two methods of incorporating transforming growth factor-beta 3 within collagen-hyaluronic acid scaffolds are described, markedly improving mesenchymal stem cell-mediated chondrogenic differentiation and matrix production. Such scaffolds offer control over the release of therapeutics, demonstrating their potential for repair of complex chondral defects requiring additional stimuli.
authors: Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.|Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.|Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin 2, Ireland.
authors: Amos
authors: A
authors: Matsiko
authors: Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.|Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.|Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin 2, Ireland.
authors: Tanya J
authors: TJ
authors: Levingstone
authors: Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.|Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.|Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin 2, Ireland.|SurgaColl Technologies Ltd, Rubicon Centre, Rossa Avenue, Cork, Ireland.
authors: John P
authors: JP
authors: Gleeson
authors: Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.|Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland.|Advanced Materials and Bioengineering Research (AMBER) Centre, RCSI and TCD, Dublin 2, Ireland.
authors: Fergal J
authors: FJ
authors: O'Brien
mesh_terms: D053674:Aggrecans / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002454:Cell Differentiation; D002478:Cells, Cultured; D020219:Chondrogenesis; D003094:Collagen / Q000737:chemistry*; D024043:Collagen Type II / Q000235:genetics / Q000378:metabolism; D006025:Glycosaminoglycans / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D055747:SOX Transcription Factors / Q000235:genetics* / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D053782:Transforming Growth Factor beta3 / Q000737:chemistry*
chemical_list: C508321:Acan protein, rat; D053674:Aggrecans; D001672:Biocompatible Materials; C511513:COL2A1 protein, rat; D024043:Collagen Type II; D006025:Glycosaminoglycans; D055747:SOX Transcription Factors; D053782:Transforming Growth Factor beta3; C058506:collagen-glycosaminoglycan copolymer; D012710:Serum Albumin, Bovine; D006820:Hyaluronic Acid; D003094:Collagen
keywords: articular cartilage; collagen-based scaffolds; growth factor delivery; mesenchymal stem cells; transforming growth factor-beta 3