title: IgE-Mediated allergy to wheat in a child with celiac disease - a case report.
abstract: BACKGROUND
  Celiac disease and immediate type hypersensitivity to wheat are immune responses with different pathogenic mechanisms. Both diseases are well known entities but their coexistence in the same patient is rarely reported. This is a unique case presentation of a patient with celiac disease who developed concomitant IgE-mediated wheat allergy and presented with immediate symptoms in two body systems.
  
  
  METHODS
  We report the case of a girl with celiac disease who subsequently developed IgE-mediated hypersensitivity to wheat. The patient is a Caucasian female who was diagnosed with celiac disease at 18 months of age after presenting with recurrent vomiting and failure to thrive. Her anti-tTG antibody level was greater than 200 E.U. and biopsy results from endoscopy were consistent with celiac disease. Specific IgE antibody to wheat was negative at 2 years of age. Around seven years of age, she developed immediate symptoms of urticaria, cough and shortness of breath with accidental exposures to wheat. Specific IgE antibody testing was repeated and positive to wheat (42.5 kU/L), as well as rye (33.9 kU/L), barley (53.4 kU/L) and oat (11.3 kU/L). At 9 years of age, skin prick testing was positive to wheat, barley and rye but negative to oat. The patient has subsequently tolerated an open oral food challenge to oat. She continues to avoid wheat, rye and barley and carries an epinephrine autoinjector at all times.
  
  
  CONCLUSIONS
  To our knowledge, this is the first report of a patient with celiac disease and concomitant IgE-mediated allergy to wheat presenting with immediate symptoms in two body systems. Although the pathophysiology of these diseases is different, this case demonstrates that they are not exclusive of one another. In patients who develop unexplained symptoms consistent with IgE-mediated allergy, an allergy assessment should be considered.
authors: BC Children's Hospital, Allergy Clinic, Room 1C31B, 4480 Oak St, Vancouver, BC V6H 3 V4 Canada.
authors: Tiffany
authors: T
authors: Wong
authors: Department of Medicine, Division of Gastroenterology, 770-1190 Hornby Street, Vancouver, BC V6Z 2 K5 Canada.
authors: Hin Hin
authors: HH
authors: Ko
authors: BC Children's Hospital, Allergy Clinic, Room 1C31B, 4480 Oak St, Vancouver, BC V6H 3 V4 Canada.
authors: Edmond S
authors: ES
authors: Chan
keywords: Allergy; Celiac disease; Wheat