title: Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation.
abstract: We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J (n = 16) and DBA/2J (n = 15) and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties (P < 0.05) in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.
authors: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Yueying
authors: Y
authors: Zhang
authors: Department of Medicine-Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Jinsong
authors: 0000-0002-1138-5802
authors: J
authors: Huang
authors: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Yan
authors: 0000-0002-3913-8918
authors: Y
authors: Jiao
authors: Department of Medicine-Nephrology, University of Tennessee Health Science Center, Memphis, TN 38163, USA ; Division of Nephrology, Northwestern University, Chicago, IL 60208, USA.
authors: Valentin
authors: 0000-0001-9527-2364
authors: V
authors: David
authors: Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Mehmet
authors: 0000-0002-3386-1734
authors: M
authors: Kocak
authors: Department of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.
authors: Esra
authors: 0000-0002-0818-687X
authors: E
authors: Roan
authors: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Denis
authors: 0000-0002-8256-447X
authors: D
authors: Di'Angelo
authors: Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Lu
authors: L
authors: Lu
authors: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Karen A
authors: KA
authors: Hasty
authors: Department of Orthopaedic Surgery and Biomedical Engineering, Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors: Weikuan
authors: 0000-0003-1112-8088
authors: W
authors: Gu
mesh_terms: D000818:Animals; D015519:Bone Density; D005260:Female; D005269:Femur / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D010641:Phenotype; D011995:Recombination, Genetic; D013045:Species Specificity; D013977:Tibia / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology; D055114:X-Ray Microtomography