title: Cerebrolysin Accelerates Metamorphosis and Attenuates Aging-Accelerating Effect of High Temperature in Drosophila Melanogaster.
abstract: Cerebrolysin® (CBL) is a neuroprotective drug used for the treatment of neurodegenerative diseases. CBL's mechanisms of action remain unclear. Involvement of tryptophan (TRP)-kynurenine (KYN) pathway in neuroprotective effect of CBL might be suggested considering that modulation of KYN pathway of TRP metabolism by CBL, and protection against eclosion defect and prolongation of life span of Drosophila melanogaster with pharmacologically or genetically-induced down-regulation of TRP conversion into KYN. To investigate possible involvement of TRP-KYN pathway in mechanisms of neuroprotective effect of CBL, we evaluated CBL effects on metamorphosis and life span of Drosophila melanogaster maintained at 23 °C and 28 °C ambient temperature. CBL accelerated metamorphosis, exerted strong tendency (p= 0.04) to prolong life span in female but not in male flies, and attenuated aging-accelerating effect of high (28 °C) ambient temperature in both female and male flies. Further research of CBL effects on metamorphosis and resistance to aging-accelerating effect of high temperature might offer new insights in mechanisms of its neuroprotective action and expand its clinical applications.
authors: Department of Genetics and Cytology, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine.
authors: V
authors: V
authors: Navrotskaya
authors: Neuroinflammation Program, Department of Psychiatry, Tufts University/Tufts Medical Center, Boston, MA, USA.
authors: G
authors: G
authors: Oxenkrug
authors: Department of Genetics and Cytology, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine.
authors: L
authors: L
authors: Vorobyova
authors: Cerebrovascular Research Laboratory, Department of Surgical Sciences, Anesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Uppsala, Sweden.
authors: H
authors: H
authors: Sharma
authors: Department of Neurology, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania.
authors: D
authors: D
authors: Muresanu
authors: Neuroinflammation Program, Department of Psychiatry, Tufts University/Tufts Medical Center, Boston, MA, USA.
authors: P
authors: P
authors: Summergrad
keywords: Aging; Cerebrolysin; Drosophila; Eclosion; High Temperature; Kynurenine; Life Span; Metamorphosis; Neuroprotection; Tryptophan