title: Optimizing treatments for anxiety by age and genetics.
abstract: This paper highlights recent human neuroimaging and cross-species developmental and genetic studies that examine how fear regulation varies by age and the individual, especially during the period of adolescence, when there is a peak in the prevalence of anxiety disorders. The findings have significant implications for understanding who may be at risk for anxiety disorders and for whom, and when, an exposure-based therapy may be most effective. We provide proof of concept for targeting treatment to the individual as a function of age and genetics, inferred from mouse and human studies, and suggest optimization of treatment for nonresponders.
authors: Department of Psychiatry, Weill Cornell Medical College, Sackler Institute for Developmental Psychobiology, New York, New York.
authors: B J
authors: BJ
authors: Casey
authors: Department of Psychiatry, Weill Cornell Medical College, Sackler Institute for Developmental Psychobiology, New York, New York.
authors: Francis S
authors: FS
authors: Lee
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000818:Animals; D001007:Anxiety / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D005239:Fear / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D009415:Nerve Net / Q000502:physiology; D059906:Neuroimaging; D057285:Precision Medicine / Q000379:methods / Q000592:standards*
keywords: anxiety; development; genetics