title: The association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population: evidence from an updated meta-analysis.
abstract: Previous studies have reported the association of glutathione S-transferase M1 (GSTM1) deletion polymorphism with genetic susceptibility of lung cancer in Chinese population. However, the results remained controversial. The aim of this study was to clarify the association of GSTM1 deletion polymorphism with lung cancer risk in Chinese population. Systematic searches were performed through the search engines of Medline/Pubmed, Web of Science, EMBASE, CNKI and Wanfang Medical Online. The pooled effects were calculated by STATA 10.0 software package and Review Manager 5.0.24. Overall, we observed an association of GSTM1 deletion polymorphism with increased lung cancer risk in Chinese population (odds ratio (OR) = 1.46, 95% confidence interval (95%CI): 1.32-1.66 for null genotype vs. present genotype) based on 53 studies including 7,833 cases and 10,353 controls. We also observed an increased risk of GSTM1 null genotype for lung cancer in stratified analyses by source of control, smoking status and histological type. The findings suggest that GSTM1 deletion polymorphism may contribute to lung cancer risk in Chinese population. Further, well-designed studies with larger sample sizes are required to verify the results.
authors: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors: Haiyan
authors: H
authors: Yang
authors: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors: Siyu
authors: S
authors: Yang
authors: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors: Jing
authors: J
authors: Liu
authors: Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors: Fuye
authors: F
authors: Shao
authors: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
authors: Haiyu
authors: H
authors: Wang
authors: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou 450016, China.
authors: Yadong
authors: Y
authors: Wang
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D017353:Gene Deletion; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology
chemical_list: D005982:Glutathione Transferase