title: Investigation of TNF-alpha gene (G308A) and GSTP1 gene (Ilel05Val) polymorphisms in Turkish patients with retinopathy of prematurity.
abstract: OBJECTIVE
  Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood.-In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ilel05Val) gene polymorphism.
  
  
  METHODS
  Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ilel05Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance level was determined as P < 0.05.
  
  
  RESULTS
  When the patient and control groups were compared in terms of TNF-alpha (G308A) gene and GSTP1 (Ilel05Val) gene polymorphisms, no statistically significant difference was found (P > 0.05).
  
  
  CONCLUSIONS
  In our study, no correlation was identified between TNF-alpha (G308A) gene and GSTP1 (Ilel05Val) gene polymorphisms and susceptibility for development of ROP. Further studies are required with more cases of ROP patients and other gene polymorphisms that could be related.
authors: Mehmet
authors: M
authors: Türe
authors: Meral
authors: M
authors: Yildiz
authors: Mutlu
authors: M
authors: Karkucak
authors: Emine Tuna
authors: ET
authors: Gülten
authors: Deniz
authors: D
authors: Siğirli
authors: Ahmet Tuncer
authors: AT
authors: Özmen
authors: Tahsin
authors: T
authors: Yakut
mesh_terms: D016022:Case-Control Studies; D005260:Female; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011110:Polymorphism, Genetic; D012178:Retinopathy of Prematurity / Q000453:epidemiology / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: D014409:Tumor Necrosis Factor-alpha; D051549:Glutathione S-Transferase pi