title: Evaluation of stability and capsular bag opacification of a new foldable adjustable intraocular lens.
abstract: BACKGROUND
  Incorrect lens power remains one of the most common reasons for intraocular lens explantation/exchange. We evaluated stability and effect on capsular bag opacification of a new foldable modular lens system, with a base component and an optic component in rabbit eyes.
  
  
  METHODS
  Bilateral phacoemulsification was performed on six rabbits; one eye received the test lens (Harmoni Modular Lens, ClarVista Medical), whereas the other received a single-piece hydrophobic acrylic control lens (SA60AT, Alcon). Slit-lamp examinations were performed at postoperative weeks 1, 2, 3, 4 and 6. All rabbits were sacrificed at week 6. After enucleation, the eyes were examined grossly from the Miyake-Apple view. Following, all globes were sectioned and processed for histopathological examination.
  
  
  RESULTS
  The modular lens was stable in all six rabbits. Uveal biocompatibility was similar to or better in the test eyes when compared with control eyes up to 6 weeks postoperatively. Overall, capsular bag opacification was found to be significantly lower in the test eyes when compared with control eyes. At the 6-week gross examination, central posterior capsule opacification was scored as 0.58 ± 0.73 in the test group, and as 3.00 ± 1.26 in the control group (paired two samples for means t-test; two-tail P = 0.005).
  
  
  CONCLUSIONS
  The Harmoni Modular system remains stable within the capsular bag after implantation. Due to the design of the base component featuring long loops, along with peripheral anterior and posterior square edges, the lens appeared to prevent overall capsular bag opacification in the rabbit model.
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: Kyle D
authors: KD
authors: MacLean
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: Liliana
authors: L
authors: Werner
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: Gregory D
authors: GD
authors: Kramer
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: M Aabid
authors: MA
authors: Farukhi
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: Gareth L
authors: GL
authors: Gardiner
authors: Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors: Malik Y
authors: MY
authors: Kahook
authors: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
authors: Nick
authors: N
authors: Mamalis
mesh_terms: D000818:Animals; D000869:Anterior Eye Segment / Q000473:pathology; D060437:Artificial Lens Implant Migration / Q000517:prevention & control*; D058442:Capsule Opacification / Q000517:prevention & control*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008422:Materials Testing; D018918:Phacoemulsification; D011474:Prosthesis Design; D011817:Rabbits; D066167:Slit Lamp
keywords: cataract surgery; intraocular lens; posterior capsule opacification