title: The clinical-psychological features of functional dyspepsia patients with weight loss: a multi-center study from China.
abstract: OBJECTIVE
  To investigate the clinical features, appetite, quality of life (QOL), and their associated psychological factors of functional dyspepsia (FD) patients with weight loss.
  
  
  METHODS
  For a multicenter study, FD patients were recruited and divided into two groups according to the degree of weight changes during the previous 12 months or less with the onset of dyspepsia symptoms: Group A (≥5%) and Group B (<5%). Patients were evaluated based on the Nepean dyspepsia index (NDI), appetite questionnaire, Hamilton Rating Scale of Anxiety/Depression (HAMA/HAMD).
  
  
  RESULTS
  The body mass index in Group A was lower than in Group B, while, the frequency of physician visits in Group A was higher than in Group B. There were no differences in the total scores of NDI-symptom checklist or the items of intensity and bothersomeness between them (p > 0.05), but the frequency item for Group A was significantly higher than Group B (p = 0.035). The incidence of anxiety or depression, the proportion of poor or very poor appetite for Group A was higher than those for Group B (p < 0.05). Subscale scores of the NDI-QOL for Group A were significantly lower than those for Group B (p < 0.05).
  
  
  CONCLUSIONS
  FD patients with weight loss have lower BMI, more frequent physician visits, higher psychological disorders, poorer appetite and QoL.
authors: Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
authors: Jing
authors: J
authors: Liu
authors: Lin
authors: L
authors: Jia
authors: Xiao-Gai
authors: XG
authors: Lei
authors: Shu-Man
authors: SM
authors: Jiang
authors: Sheng-Bing
authors: SB
authors: Wang
authors: Ming
authors: M
authors: Xu
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications / Q000453:epidemiology; D001066:Appetite; D015992:Body Mass Index; D002681:China; D003863:Depression / Q000150:complications / Q000453:epidemiology; D004415:Dyspepsia / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009819:Office Visits / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D011795:Surveys and Questionnaires; D015431:Weight Loss