title: Beneficial Effects of Teucrium polium and Metformin on Diabetes-Induced Memory Impairments and Brain Tissue Oxidative Damage in Rats.
abstract: Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3-6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally). Results. In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group (P < 0.01). In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group (P < 0.01). Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control (P < 0.001). Treatment by all doses of the extract and metformin decreased the MDA concentration (P < 0.01). Conclusions. The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats. Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin.
authors: Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: S Mojtaba
authors: SM
authors: Mousavi
authors: Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: Saeed
authors: S
authors: Niazmand
authors: Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: Mahmoud
authors: M
authors: Hosseini
authors: Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: Zarha
authors: Z
authors: Hassanzadeh
authors: Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: Hamid Reza
authors: HR
authors: Sadeghnia
authors: Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors: Farzaneh
authors: F
authors: Vafaee
authors: Department of Physiology, School of Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran.
authors: Zakieh
authors: Z
authors: Keshavarzi