title: The functional anatomy of psychomotor disturbances in major depressive disorder.
abstract: Psychomotor disturbances (PMD) are a classic feature of depressive disorder that provides rich clinical information. The aim our narrative review was to characterize the functional anatomy of PMD by summarizing findings from neuroimaging studies. We found evidence across several neuroimaging modalities that suggest involvement of fronto-striatal neurocircuitry, and monoaminergic pathways and metabolism. We suggest that PMD in major depressive disorder emerge from an alteration of limbic signals, which influence emotion, volition, higher-order cognitive functions, and movement.
authors: Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet , Stockholm , Sweden.
authors: Benny
authors: B
authors: Liberg
authors: Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne , Melbourne, VIC , Australia ; Unit of Metabolism, Department of Medicine Huddinge, Karolinska Institutet , Stockholm , Sweden.
authors: Christoffer
authors: C
authors: Rahm
keywords: basal ganglia; frontal lobe; major depressive disorder; monoamines; neuroimaging; psychomotor performance