title: Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study).
abstract: Although subjects with chronic kidney disease (CKD) are at markedly increased risk for cardiovascular mortality, the relation between CKD and aortic valve calcification has not been fully elucidated. Also, few data are available on the relation of aortic valve calcification and earlier stages of CKD. We sought to assess the relation of aortic valve calcium (AVC) with estimated glomerular filtration rate (eGFR), traditional and novel cardiovascular risk factors, and markers of bone metabolism in the Chronic Renal Insufficiency Cohort (CRIC) Study. All patients who underwent aortic valve scanning in the CRIC study were included. The relation between AVC and eGFR, traditional and novel cardiovascular risk factors, and markers of calcium metabolism were analyzed using both unadjusted and adjusted regression models. A total of 1,964 CRIC participants underwent computed tomography for AVC quantification. Decreased renal function was independently associated with increased levels of AVC (eGFR 47.11, 44.17, and 39 ml/min/1.73 m2, respectively, p<0.001). This association persisted after adjusting for traditional, but not novel, AVC risk factors. Adjusted regression models identified several traditional and novel risk factors for AVC in patients with CKD. There was a difference in AVC risk factors between black and nonblack patients. In conclusion, our study shows that eGFR is associated in a dose-dependent manner with AVC in patients with CKD, and this association is independent of traditional cardiovascular risk factors.
authors: Cardiovascular Medicine Division, Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: marie.guerraty@uphs.upenn.edu.
authors: Marie A
authors: MA
authors: Guerraty
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Boyang
authors: B
authors: Chai
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Jesse Y
authors: JY
authors: Hsu
authors: Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan.
authors: Akinlolu O
authors: AO
authors: Ojo
authors: Temple Heart and Vascular Center, Temple University, Philadelphia, Pennsylvania.
authors: Yanlin
authors: Y
authors: Gao
authors: Department of Biostatistics and Epidemiology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Wei
authors: W
authors: Yang
authors: Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California.
authors: Martin G
authors: MG
authors: Keane
authors: Temple Heart and Vascular Center, Temple University, Philadelphia, Pennsylvania.
authors: Matthew J
authors: MJ
authors: Budoff
authors: Vascular Medicine Section, Cardiovascular Medicine Division, Department of Medicine, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.
authors: Emile R
authors: ER
authors: Mohler
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000473:pathology* / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D002097:C-Reactive Protein / Q000378:metabolism; D002114:Calcinosis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D017270:Lipoprotein(a); D002097:C-Reactive Protein