title: The experimental model of nephrotic syndrome induced by Doxorubicin in rodents: an update.
abstract: Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, generalized edema, and hyperlipidemia. It begins by changes in the glomerular filtration barrier, with increased permeability to plasma proteins. It affects all age groups and can progress to end-stage renal disease. NS pathophysiology is still unknown. However, the critical role of the immune system is well recognized. Animal models are useful tools for the investigation of NS. Among different experimental models proposed in the literature, disease induced by Doxorubicin has been considered helpful to the purpose of many studies. The aim of this review article is to describe the animal model of NS induced by the injection of Doxorubicin in rodents, with emphasis on action of the drug, potential mechanisms of renal injury, as well biochemical, histological, and corporal changes obtained with this model.
authors: Laboratório de Imunologia do Centro Integrado de Pesquisa em Saúde, Universidade Federal do Vale do Jequitinhonha e Mucuri, Diamantina, Minas Gerais, Brazil.
authors: Wagner de Fátima
authors: Wde F
authors: Pereira
authors: Gustavo Eustáquio A
authors: GE
authors: Brito-Melo
authors: Cayo Antônio Soares
authors: CA
authors: de Almeida
authors: Lázaro Lopes
authors: LL
authors: Moreira
authors: Cleiton Willian
authors: CW
authors: Cordeiro
authors: Thiago Guimarães Rosa
authors: TG
authors: Carvalho
authors: Elvis Cueva
authors: EC
authors: Mateo
authors: Ana Cristina
authors: AC
authors: Simões E Silva
mesh_terms: D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D004195:Disease Models, Animal; D004317:Doxorubicin; D006801:Humans; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D051381:Rats
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin