title: Strain wave elastography for evaluation of renal parenchyma in chronic kidney disease.
abstract: OBJECTIVE
  Chronic kidney disease (CKD) is an important and costly health problem in developed countries and has a tendency to progress to end-stage renal disease regardless of the aetiology. This progress ends in interstitial fibrosis, which decreases the elasticity of tissue. Elastography is a developing technique to assess tissue elasticity. The aim of this study was to determine the difference of strain index (SI) value of renal parenchyma between patients with CKD and healthy individuals. In addition, SI differences of inter-stages were studied.
  
  
  METHODS
  Toshiba (Toshiba Medical Systems Corporation, Otawara, Japan) Aplio™ 500 ultrasound device and 3.5- to 5.0-MHz convex probe were used for the elastography examinations.
  
  
  RESULTS
  A total of 58 patients with CKD from nephrology and endocrinology clinics (30 males and 28 females; mean age, 56.14 ± 11.60 years) and 40 normal healthy individuals (19 males and 21 females; mean age, 51.70 ± 11.71 years) were included in this prospective study. The mean SI of normal healthy individuals and patients with CKD (regardless of stages) was 0.42 ± 0.30 and 1.81 ± 0.88, respectively (p < 0.001). SI values were not statistically significant among the CKD stages (except CKD Stages 1 and 3). The area under the receiver operating characteristic curve was 0.956 for SI. The optimal cut-off value for the prediction of CKD was 0.935 (sensitivity, 88% and specificity, 95%).
  
  
  CONCLUSIONS
  SI value of sonoelastography can be used to differentiate patients with CKD and healthy individuals. Sonoelastography is an acceptable technique to approach patients with CKD, but we have not shown that it can reliably differentiate different stages.
  
  
  CONCLUSIONS
  Determining a cut-off SI value between normal and diseased renal parenchyma can help in the diagnosis of CKD.
authors: 1 Department of Radiology, Gazi University School of Medicine, Ankara, Turkey.
authors: M S
authors: MS
authors: Menzilcioglu
authors: M
authors: M
authors: Duymus
authors: S
authors: S
authors: Citil
authors: S
authors: S
authors: Avcu
authors: G
authors: G
authors: Gungor
authors: T
authors: T
authors: Sahin
authors: S N
authors: SN
authors: Boysan
authors: O
authors: O
authors: Altunoren
authors: A
authors: A
authors: Sarica
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results