title: Interleukin-10-1082A/G polymorphism and diabetic nephropathy: a meta-analysis.
abstract: BACKGROUND
  Studies have assessed the association between Interleukin-10 (IL-10) -1082A/G polymorphism and diabetic nephropathy (DN) risk, but the results were inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between IL10-1082A/G polymorphism and DN risk.
  
  
  METHODS
  All relevant studies were searched by using PubMed and EMBASE. Data were extracted by 2 authors independently. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  Nine case-control studies with 4165 subjects were included in this meta-analysis. We found that IL10-1082A/G polymorphism was significantly associated with an increased DN risk (OR=1.21; 95% CI 1.07-1.37; P=0.002). In the subgroup analysis by race, both Caucasians and Asians with IL10-1082A/G polymorphism showed increased DN risk (OR=1.25; 95% CI 1.03-1.52; P=0.03 and OR=1.25; 95% CI 1.04-1.49; P=0.02), respectively. When we deleted the study without diabetes type, the result was not altered (OR=1.21; 95% CI 1.02-1.44; P=0.03). In the subgroup analysis by sample size, both studies with large sample size and studies with small sample size showed increased DN risk (OR=1.16; 95% CI 1.02-1.31; P=0.02 and OR=1.50; 95% CI 1.14-1.98; P=0.004), respectively.
  
  
  CONCLUSIONS
  This meta-analysis confirmed that IL10-1082A/G polymorphism might contribute to the susceptibility for DN.
authors: Department of Nephrology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland).
authors: Xia
authors: X
authors: Peng
authors: Department of Nephrology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland).
authors: Jiayun
authors: J
authors: Xu
authors: Department of Cardiology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland).
authors: Pengpeng
authors: P
authors: Wang
authors: Department of Nephrology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland).
authors: Jinjin
authors: J
authors: Zhou
authors: Department of Gastroenterology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China (mainland).
authors: Hong
authors: H
authors: Guo
mesh_terms: D003928:Diabetic Nephropathies / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10