title: Preparation, spectroscopic and antibacterial studies on charge-transfer complexes of 2-hydroxypyridine with picric acid and 7,7',8,8'-tetracyano-p-quinodimethane.
abstract: The reactions of electron acceptors such as picric acid (HPA) and 7,7',8,8'-tetracyano-p-quinodimethane (TCNQ) with 2-hydroxypyridine (HPyO) have been investigated in EtOH at room temperature. Based on elemental analysis and IR spectra of the solid CT-complexes along with the photometric titration curves for the reactions, the data obtained indicate the formation of 1:1 charge transfer complexes [(H2PyO)(PA)] and [(PyO)(HTCNQ)], respectively. The infrared and (1)H NMR spectroscopic data indicate a charge transfer interaction associated with a proton migration from the acceptor to the donor followed by intramolecular hydrogen bonding in [(H2PyO)(PA)] complex. Another charge transfer interaction was observed in [(PyO)(HTCNQ)] complex. The formation constants (KCT) for the CT-complexes are shown to be strongly dependent on the type and structure of the electron acceptors. Factors affecting the CT-processes and the kinetics of thermal decomposition of the complexes have been studied. The CT complexes were screened for their antibacterial activities against selected bacterial strains.
authors: Faculty of Specific Education, Zagazig University, Zagazig, Egypt. Electronic address: akmalsg@zu.edu.eg.
authors: Akmal S
authors: AS
authors: Gaballa
authors: Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.
authors: Alaa S
authors: AS
authors: Amin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004583:Electrons; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D011728:Pyridones / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013818:Thermogravimetry
chemical_list: D000900:Anti-Bacterial Agents; D009570:Nitriles; D010851:Picrates; D011728:Pyridones; C013703:tetracyanoquinodimethane; C017679:2-hydroxypyridine; C005858:picric acid
keywords: 2-Hydroxypyridine; Antibacterial activity; Charge transfer; Kinetics of thermal decomposition; Spectroscopy; TGA spectrometry