title: Role of lipid microdomains in TLR-mediated signalling.
abstract: Over the last twenty years, evidence has been provided that the plasma membrane is partitioned with microdomains, laterally mobile in the bilayer, providing the necessary microenvironment to specific membrane proteins for signalling pathways to be initiated. We discuss here the importance of such microdomains for Toll-like receptors (TLR) localization and function. First, lipid microdomains favour recruitment and clustering of the TLR machinery partners, i.e. receptors and co-receptors previously identified to be required for ligand recognition and signal transmission. Further, the presence of the so-called Cholesterol Recognition Amino-Acid Consensus (CRAC) sequences in the intracellular juxtamembrane domain of several Toll-like receptors suggests a direct role of cholesterol in the activation process. This article is part of a Special Issue entitled: Lipid-protein interactions.
authors: Structure and Function of Biological Membranes, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium.
authors: Jean-Marie
authors: JM
authors: Ruysschaert
authors: Structure and Function of Biological Membranes, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium; Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom. Electronic address: clonez@ulb.ac.be.
authors: Caroline
authors: C
authors: Lonez
mesh_terms: D000595:Amino Acid Sequence; D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D051193:Toll-Like Receptors; D002784:Cholesterol
keywords: CRAC; Cholesterol; Lipid microdomains; Raft; Toll-like receptors