title: Vibration inhibits deterioration in rat deep-tissue injury through HIF1-MMP axis.
abstract: Deep-tissue injury (DTI) is a unique type of pressure ulcer (PU) in which deep-tissue damage expands outwards to the superficial skin. DTI progresses rapidly into a severe PU, despite initially appearing as only a bruise or darkened tissue in the superficial skin. Although some DTI detection methods are available, there is currently no strategy for treating deteriorating DTI. This study investigated the efficacy of vibration therapy for preventing DTI deterioration through down-regulation of the hypoxia-inducible factor-1 matrix metalloproteinase (MMP) axis in rats. We prepared a conventional PU rat model (PU group) and a DTI deterioration rat model (DTI group). The DTI group was further divided into two groups subjected to vibration and control treatments, respectively. Macroscopic and histological features, hypoxia, oxidative stress, apoptosis, and MMP2 and MMP9 activities in compressed skin were analyzed. Hypoxia, oxidative stress, and MMP activity were enhanced in the DTI group compared with the PU group. Vibration remarkably inhibited DTI deterioration, hypoxia, and the expression/activities of MMP2 and MMP9. These results suggest that vibration therapy can effectively attenuate deterioration of DTI. This report provides the first evidence for a therapeutic treatment for deteriorating DTI.
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.|Department of Nursing, Jenderal Soedirman University, Purwokerto, Indonesia.
authors: Yunita
authors: Y
authors: Sari
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.
authors: Hiromi
authors: H
authors: Sanada
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.
authors: Takeo
authors: T
authors: Minematsu
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.
authors: Gojiro
authors: G
authors: Nakagami
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.
authors: Takashi
authors: T
authors: Nagase
authors: Department of Gerontological Nursing/Wound Care Management, The University of Tokyo, Tokyo, Japan.
authors: Lijuan
authors: L
authors: Huang
authors: Department of Life Support Technology (Molten), The University of Tokyo, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Noguchi
authors: Department of Life Support Technology (Molten), The University of Tokyo, Tokyo, Japan.
authors: Taketoshi
authors: T
authors: Mori
authors: Department of Plastic Surgery, The University of Tokyo, Tokyo, Japan.
authors: Kotaro
authors: K
authors: Yoshimura
authors: Wellness Promotion Science Center, Kanazawa University, Ishikawa, Japan.
authors: Junko
authors: J
authors: Sugama
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D015536:Down-Regulation; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D018384:Oxidative Stress; D003668:Pressure Ulcer / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries / Q000473:pathology*; D014732:Vibration; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D051793:Hypoxia-Inducible Factor 1; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9