title: Injection of intradiscal o2-o3 to reduce pain and disability of patients with low back pain due to prolapsed lumbar disk.
abstract: BACKGROUND
  Disk herniation (DH) is one of the most common disk lesions, inducing low back pain (LBP). Various therapeutic options have been proposed for treatment of disk herniation (DH). Intradiscal injection of ozone has been suggested for treatment of DH.
  
  
  OBJECTIVE
  To determine the effect of intradiscal ozone injection on pain score and disability in patients with LBP from disk prolapsed.
  
  
  METHODS
  Patients with LBP diagnosed with DH were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of ozone/oxygen mixture (4 mL, 40 µg/mL) was performed. Pain score and functional ability of the patients according to Oswestry Disability Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection.
  
  
  RESULTS
  Thirty patients (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean ± standard deviation (SD) of pain score before intervention was 8.1 ± 0.8. After two weeks, it was reduced to 3.2 ± 0.6 (P < 0.001) and finally dropped to 2.0 ± 0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5 ± 2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001).
  
  
  CONCLUSIONS
  Altogether, ozone had significant positive effects on patients with disk herniation unresponsive to other conservative and minimally invasive treatments.
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Masoud
authors: M
authors: Hashemi
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Majid
authors: M
authors: Poorfarokh
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Seyed Amir
authors: SA
authors: Mohajerani
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Parviz
authors: P
authors: Jalili
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Vahid
authors: V
authors: Akhyani
authors: Department of Epidemiology and Public Health, Ghazvin University of Medical Sciences, Ghazvin, Iran.
authors: Ameneh
authors: A
authors: Barikani
authors: Department of Anesthesiology and Pain Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Farshad
authors: F
authors: Farivar
keywords: Low Back Pain; Ozone; Prolapsed Disk