title: CD105 expression on CD34-negative spindle-shaped stromal cells of primary tumor is an unfavorable prognostic marker in early breast cancer patients.
abstract: Several studies have confirmed that the breast tumor microenvironment drives cancer progression and metastatic development. The aim of our research was to investigate the prognostic significance of the breast tumor microenvironment in untreated early breast cancer patients. Therefore, we analyzed the association of the expression of α-SMA, FSP, CD105 and CD146 in CD34-negative spindle-shaped stromal cells, not associated with the vasculature, in primary breast tumors with classical prognostic marker levels, metastatic recurrence, local relapse, disease-free survival, metastasis-free survival and the overall survival of patients. In the same way, we evaluated the association of the amount of intra-tumor stroma, fibroblasts, collagen deposition, lymphocytic infiltration and myxoid changes in these samples with the clinical-pathological data previously described. This study is the first to demonstrate the high CD105 expression in this stromal cell type as a possible independent marker of unfavorable prognosis in early breast cancer patients. Our study suggests that this new finding can be useful prognostic marker in the clinical-pathological routine.
authors: Immunohematology Laboratory, Experimental Biology and Medicine Institute (IBYME)-National Council of Scientific and Technical Research (CONICET), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Leandro Marcelo
authors: LM
authors: Martinez
authors: Immunohematology Laboratory, Experimental Biology and Medicine Institute (IBYME)-National Council of Scientific and Technical Research (CONICET), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Vivian
authors: V
authors: Labovsky
authors: Department of Biostatistics, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: María de Luján
authors: ML
authors: Calcagno
authors: Department of Pathological Anatomy, Italian Hospital, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Kevin Mauro
authors: KM
authors: Davies
authors: Department of Pathological Anatomy, Italian Hospital, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Hernán
authors: H
authors: Garcia Rivello
authors: Hernán Garcia
authors: HG
authors: Rivello
authors: Neuroendocrinology Laboratory, Experimental Biology and Medicine Institute (IBYME)-National Council of Scientific and Technical Research (CONICET), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Maria Silvia
authors: MS
authors: Bianchi
authors: Department of Pathological Anatomy, Italian Hospital, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Alejandra
authors: A
authors: Wernicke
authors: Valeria Beatriz Fernández
authors: VB
authors: Vallone
authors: Immunohematology Laboratory, Experimental Biology and Medicine Institute (IBYME)-National Council of Scientific and Technical Research (CONICET), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
authors: Valeria Beatriz
authors: VB
authors: Fernández Vallone
authors: Norma Alejandra
authors: NA
authors: Chasseing
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism*; D018952:Antigens, CD34 / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D051929:CD146 Antigen / Q000378:metabolism; D018572:Disease-Free Survival; D000071063:Endoglin; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012008:Recurrence; D012189:Retrospective Studies; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D015703:Antigens, CD; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D051929:CD146 Antigen; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface