title: Concise synthesis of 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones as racemic 14-azaestrogen analogs.
abstract: A concise method for the synthesis of 14-azasteroid analogs with angular methyl group at C-13 of the steroidal nucleus has been reported in this paper. We have developed an interesting cascade reaction of arylacetylenes and N-(naphthalen-2-yl)pent-4-ynamides under gold (III)-catalysis to produce novel tetracyclic 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones which may be viewed as 14-azaestrogen analogs.
authors: Department of Chemistry, Acadia University, Wolfville, NS, Canada.
authors: Ashraf M
authors: AM
authors: Abdelkhalik
authors: Department of Chemistry, Acadia University, Wolfville, NS, Canada.
authors: Nawal K
authors: NK
authors: Paul
authors: Department of Chemistry, Acadia University, Wolfville, NS, Canada. Electronic address: ajha@acadiau.ca.
authors: Amitabh
authors: A
authors: Jha
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D004967:Estrogens / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D004967:Estrogens
keywords: 12a-Methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones; 14-Azasteroids; Domino reaction; Estrogen analogs; Gold (III) catalysis