title: Lower Lid Laxity is Negatively Correlated with Improvement of the Ocular Surface Disease Index in Dry Eye Treatment.
abstract: OBJECTIVE
  To compare the responses to dry eye treatment of patients sorted by the degree of lower lid laxity.
  
  
  METHODS
  Sixty patients were grouped into three groups according to the degree of lower lid laxity. Tear break-up time (TBUT), Schirmer test (ST) scores, ocular surface disease index (OSDI) scores, and changes in OSDI score in each group were compared, before and at 3 months after treatment.
  
  
  RESULTS
  TBUT, ST, and OSDI scores were not different among the three groups at baseline. TBUT improved in each group at 3 months after treatment, and no differences between groups were found. ST scores were not increased after treatment, while OSDI were improved to 22.57 ± 5.243, 31.16 ± 11.353, and 37.85 ± 13.342 in the no, moderate, and high laxity groups, respectively; these improvements were statistically significant (p = 0.003, <0.001, <0.001, respectively). Patients with greater than moderate lower lid laxity saw the smallest improvement in response to dry eye treatment, as assessed by change in OSDI score (p = 0.005 versus moderate laxity group, p = 0.005 versus no laxity group).
  
  
  CONCLUSIONS
  Lower lid laxity is one of the factors contributing to the responses to dry eye treatment assessed by change in OSDI score, independent of TBUT and ST scores.
authors: a Department of Ophthalmology , Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors: Seung Hoon
authors: SH
authors: Oh
authors: a Department of Ophthalmology , Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors: Byul
authors: B
authors: Lyu
authors: a Department of Ophthalmology , Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors: Hye Bin
authors: HB
authors: Yim
authors: a Department of Ophthalmology , Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea , Seoul , Korea.
authors: Na Young
authors: NY
authors: Lee
mesh_terms: D003316:Corneal Diseases / Q000503:physiopathology*; D016572:Cyclosporine / Q000008:administration & dosage; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D005143:Eyelids / Q000503:physiopathology*; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D065346:Lubricant Eye Drops / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009801:Oculomotor Muscles / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013666:Tears / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D065346:Lubricant Eye Drops; D016572:Cyclosporine; D005469:Fluorometholone
keywords: Dry eye syndrome; OSDI; Schirmer test; lower lid laxity; snap back test