title: The role of fibroblast growth factor 21 in diabetes and its complications: A review from clinical perspective.
abstract: Fibroblast growth factor 21 (FGF21) has been well-recognized as a metabolic hormone and a promising target for treatment of metabolic diseases. The level of endogenous FGF21 is elevated in patients with impaired glucose tolerance and progressively increased from patients with overt type 2 diabetes to those with micro- and macro-vascular complications, presumably as a compensation or response to the deterioration of metabolic imbalance. A few exploratory in vivo studies, including a recent clinical trial, showed that exogenous FGF21 mimetics targeting FGF21 signaling can attain beneficial metabolic effects not with-standing the already elevated ambient FGF21 levels. In addition, some clinically available pharmacologic agents such as fenofibrates and metformin may modulate energy and macronutrients metabolism by acting through FGF21. This review mainly focuses on the role of FGF21 in development, progression and treatment of type 2 diabetes from a clinical perspective.
authors: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore. Electronic address: liu.jianjun@alexandrahealth.com.sg.
authors: Jian-Jun
authors: JJ
authors: Liu
authors: Department of Medicine, Changi General Hospital, Singapore.
authors: Joo Pin
authors: JP
authors: Foo
authors: Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
authors: Sylvia
authors: S
authors: Liu
authors: Diabetes Center, Khoo Teck Puat Hospital, Singapore. Electronic address: lim.su.chi@alexandrahealth.com.sg.
authors: Su Chi
authors: SC
authors: Lim
mesh_terms: D048909:Diabetes Complications / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans
chemical_list: C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
keywords: Diabetes; Diabetes complications; Diabetes therapy; Fibroblast growth factor 21