title: Structural and functional dysconnectivity of the fronto-thalamic system in schizophrenia: a DCM-DTI study.
abstract: Evidence suggests that cognitive deficits are a core feature of schizophrenia. The concept of "cognitive dysmetria" has been introduced to characterize disintegration of fronto-thalamic-cerebellar circuitry which constitutes a key network for a variety of neuropsychological symptoms in schizophrenia. The present multimodal study aimed at investigating effective and structural connectivity of the fronto-thalamic circuitry in schizophrenia. fMRI effective connectivity analysis using dynamic causal modeling (DCM) and diffusion tensor imaging (DTI) were combined to examine cognitive control processes in 38 patients with schizophrenia and 40 matched healthy controls. Significantly lower fractional anisotropy (FA) was detected in patients in the right anterior limb of the internal capsule (ALIC), the right thalamus and the right corpus callosum. During Stroop task performance patients demonstrated significantly lower activation relative to healthy controls in a predominantly right lateralized fronto-thalamo-cerebellar network. An abnormal effective connectivity was observed in the right connections between thalamus, anterior cingulate and dorsolateral prefrontal cortex. FA in the ALIC was significantly correlated with the thalamic BOLD signal, cognitive performance and fronto-thalamic effective connectivity in patients. Present data provide evidence for the notion of a structural and functional defect in the fronto-thalamo-cerebellar circuitry, which may be the basis of specific cognitive impairments in schizophrenia.
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany. Electronic address: wagner.gerd@uni-jena.de.
authors: Gerd
authors: G
authors: Wagner
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
authors: Feliberto
authors: F
authors: De la Cruz
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
authors: Claudia
authors: C
authors: Schachtzabel
authors: Medical Physics Group, Institute of Diagnostic and Interventional Radiology I, Jena University Hospital, Germany.
authors: Daniel
authors: D
authors: Güllmar
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
authors: C Christoph
authors: CC
authors: Schultz
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
authors: Ralf G
authors: RG
authors: Schlösser
authors: Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany.
authors: Karl-Jürgen
authors: KJ
authors: Bär
authors: Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany; TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany.
authors: Kathrin
authors: K
authors: Koch
mesh_terms: D000328:Adult; D016880:Anisotropy; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology*; D059907:Functional Neuroimaging; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D020772:Internal Capsule / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D012559:Schizophrenia / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D057190:Stroop Test; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology*; D055815:Young Adult
keywords: ALIC; DCM; DTI; Schizophrenia; fMRI