title: Design, synthesis and insecticidal activity of novel phenylurea derivatives.
abstract: A series of novel phenylurea derivatives were designed and synthesized according to the method of active groups linkage and the principle of aromatic groups bioisosterism in this study. The structures of the novel phenylurea derivatives were confirmed based on ESI-MS, IR and 1H-NMR spectral data. All of the compounds were evaluated for the insecticidal activity against the third instars larvae of Spodoptera exigua Hiibner, Plutella xyllostella Linnaeus, Helicoverpa armigera Hubner and Pieris rapae Linne respectively, at the concentration of 10 mg/L. The results showed that all of the derivatives displayed strong insecticidal activity. Most of the compounds presented higher insecticidal activity against S. exigua than the reference compounds tebufenozide, chlorbenzuron and metaflumizone. Among the synthesized compounds, 3b, 3d, 3f, 4b and 4g displayed broad spectrum insecticidal activity.
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China. sunjialong6289@163.com.
authors: Jialong
authors: J
authors: Sun
authors: College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China. zym7410@163.com.
authors: Yuanming
authors: Y
authors: Zhou
mesh_terms: D000818:Animals; D015195:Drug Design; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007915:Lepidoptera / Q000187:drug effects; D015394:Molecular Structure; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066244:Proton Magnetic Resonance Spectroscopy; D018411:Spodoptera / Q000187:drug effects
chemical_list: D007306:Insecticides; D010671:Phenylurea Compounds