title: The flavan-isoflavan rearrangement: bioinspired synthetic access to isoflavonoids via 1,2-shift-alkylation sequence.
abstract: An approach to 2-substituted isoflavonoids is reported based on the 1,2-shift of the aryl group in the catechin skeleton followed by the in situ alkylation. Synthesis of (-)-equol, a natural isoflavan with estrogenic activities, was achieved.
authors: Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro, Tokyo 152-8551, Japan. kohmori@chem.titech.ac.jp ksuzuki@chem.titech.ac.jp.
authors: Kayo
authors: K
authors: Nakamura
authors: Ken
authors: K
authors: Ohmori
authors: Keisuke
authors: K
authors: Suzuki
mesh_terms: D000478:Alkylation; D032701:Biomimetics; D060326:Chemistry Techniques, Synthetic; D005415:Flavins / Q000737:chemistry*; D007529:Isoflavones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D005415:Flavins; D007529:Isoflavones