title: Evaluation of mineral status in hypertensive patients undergoing pharmacotherapy.
abstract: BACKGROUND
  The widespread and increasing occurrence of obesity, hypertension and associated disease has necessitated serial testing in order that risks of contracting such conditions become minimised through appropriate therapy and prevention. Many studies report that nutritional factors significantly affect the aetiology of hypertension and obesity that include mineral uptake. There are only a few studies however which are focused on the body's changing mineral content during pharmaco-therapeutic treatment.
  
  
  OBJECTIVE
  To determine concentrations of minerals in the hair and urine of hypertensive patients in conjunction with assessing their nutrition.
  
  
  METHODS
  Subjects were 17 patients presenting with essential hypertension and 18 healthy controls. Atomic absorption spectrometry (AAS) was used to measure Mg, Ca, Fe, Zn and Cu in the hair and urine on a Zeiss AAS-3 instrument. Dietary mineral intakes were assessed by interview over 24 hours prior to the analysis.
  
  
  RESULTS
  The hypertensive group had significantly lower urine concentrations of Ca and Mg as well as Mg and Zn in hair. Urinary zinc excretion was significantly increased in this group compared to controls, but dietary intakes of Cu were reduced. The dietary mineral intakes were found to be unrelated to the concentrations of such minerals in the hair and urine.
  
  
  CONCLUSIONS
  Compared to controls, excretion of Ca and Mg were reduced in hypertensive subjects, whereas Zn excretion was higher, and Mg and Zn were relatively low in the hair. Daily dietary intakes of Cu were also reduced in the hypertensive.
authors: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland.
authors: Katarzyna
authors: K
authors: Marcinek
authors: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland.
authors: Joanna
authors: J
authors: Suliburska
authors: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Poznan, Poland.
authors: Zbigniew
authors: Z
authors: Krejpcio
authors: Department of Internal Medicine, Metabolic Disorders and Hypertension, University of Medical Science, Poznan, Poland.
authors: Paweł
authors: P
authors: Bogdański
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006304:Health Status; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine*; D007408:Intestinal Absorption / Q000502:physiology; D008297:Male; D008903:Minerals / Q000652:urine*; D009752:Nutritional Status; D014131:Trace Elements / Q000652:urine*
chemical_list: D000959:Antihypertensive Agents; D008903:Minerals; D014131:Trace Elements