title: NAD in RNA: unconventional headgear.
abstract: Although widely assumed to bear a 5'-terminal triphosphate or monophosphate, recent evidence suggests that the 5' end of bacterial RNA can sometimes bear a modification reminiscent of a eukaryotic cap. A new study has now identified Escherichia coli RNAs that begin with a noncanonical cap resembling the redox cofactor nicotinamide adenine dinucleotide (NAD), as well as a cellular enzyme that can remove it. The biological function of such caps remains to be determined.
authors: Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
authors: Daniel J
authors: DJ
authors: Luciano
authors: Kimmel Center for Biology and Medicine at the Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. Electronic address: joel.belasco@med.nyu.edu.
authors: Joel G
authors: JG
authors: Belasco
mesh_terms: D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D009243:NAD / Q000737:chemistry*; D012329:RNA, Bacterial / Q000737:chemistry* / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D012329:RNA, Bacterial; D009243:NAD
keywords: NudC; RNA I; RNA degradation; RNase E; RppH; sRNA