title: Monoamine oxidase a promoter variable number of tandem repeats (MAOA-uVNTR) in alcoholics according to Lesch typology.
abstract: BACKGROUND
  The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch's typology.
  
  
  METHODS
  DNA was provided from alcohol dependent (AD) patients (n=370) and healthy control subjects (n=168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods.
  
  
  RESULTS
  We found no association between alcohol dependence and MAOA gene polymorphism.
  
  
  CONCLUSIONS
  Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.
authors: Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland. samoaga@tlen.pl.
authors: Agnieszka
authors: A
authors: Samochowiec
authors: Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland. magda.chec@gmail.com.
authors: Magdalena
authors: M
authors: Chęć
authors: University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland. edi55@wp.pl.
authors: Edyta
authors: E
authors: Kopaczewska
authors: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. samoj@pum.edu.pl.
authors: Jerzy
authors: J
authors: Samochowiec
authors: Department of Psychiatry, Vienna University, Waehringer Guertel 18-20, A-1090 Vienna, Austria. otto-michael.lesch@meduniwien.ac.at.
authors: Otto
authors: O
authors: Lesch
authors: Department of Nursing, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland. grochans@pum.edu.pl.
authors: Elżbieta
authors: E
authors: Grochans
authors: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. andrzej.jasiewicz@gmail.com.
authors: Andrzej
authors: A
authors: Jasiewicz
authors: Institute of Psychiatry and Neurology, Department of Pharmacology, Sobieskiego 9, 02-957 Warszawa, Poland. bienkow@ipin.edu.pl.
authors: Przemyslaw
authors: P
authors: Bienkowski
authors: Department of Orthopedics, Pomeranian Medical University, Unii Lubelskiej 1, 71-460 Szczecin, Poland. Lukas@hot.pl.
authors: Kołodziej
authors: K
authors: Łukasz
authors: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. annagrzywacz@gazeta.pl.
authors: Anna
authors: A
authors: Grzywacz
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
chemical_list: D005819:Genetic Markers; D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human