title: Changing Etiological Trends in Male Precocious Puberty: Evaluation of 100 Cases with Central Precocious Puberty over the Last Decade.
abstract: OBJECTIVE
  There are few studies in the literature that have evaluated the etiological factors in boys with central precocious puberty (CPP), and these studies are limited in terms of the sample size. In the present study, we aimed to evaluate the etiological factors in male CPP cases.
  
  
  METHODS
  One hundred male CPP subjects, aged between 9 months and 10.5 years, were included. The medical records were screened, and age at diagnosis, bone age, body weight, height, pubertal stage, imaging findings of the pituitary gland, testosterone, and basal and stimulated gonadotropin levels were recorded.
  
  
  RESULTS
  There was no underlying cause in 74% of the cases, and an organic cause was determined in only 26%. Most of the organic cases had been diagnosed before the age of 7 years, whereas most of the idiopathic cases had been diagnosed after the age of 7 years.
  
  
  CONCLUSIONS
  An organic cause was determined in 26% of the male patients with CPP. This rate is one of the lowest rates in the literature and indicates that the number of idiopathic male CPP cases is increasing over time. When a boy is diagnosed with CPP above the age of 7 years, the odds of detecting an underlying pathology are very low, and these cases are mostly idiopathic.
authors: Department of Pediatric Endocrinology, Hacettepe University, Ankara, Turkey.
authors: Ayfer
authors: A
authors: Alikasifoglu
authors: Dogus
authors: D
authors: Vuralli
authors: E Nazli
authors: EN
authors: Gonc
authors: Alev
authors: A
authors: Ozon
authors: Nurgun
authors: N
authors: Kandemir
mesh_terms: D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000097:blood*; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011629:Puberty, Precocious / Q000097:blood / Q000209:etiology*; D013739:Testosterone / Q000097:blood*
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone