title: Associations between polymorphisms in the NR1D1 gene encoding for nuclear receptor REV-ERBα and circadian typologies.
abstract: Nuclear receptor REV-ERBα, a key component of an internal timekeeping system, has been considered to be related to disrupted circadian rhythms and mood disorder. In this study, we aimed to evaluate the relationship between the genotype frequencies of single gene polymorphisms (SNPs) of the NR1D1 gene encoding REV-ERBα and circadian typologies. The classification of chronotypes and genotyping of three SNPs (rs2314339, rs2071427, rs12941497) of the NR1D1 gene were conducted in 602 healthy young adults (355 males, 247 females). A significant association was found between the genotypes of rs12941497 and three chronotype categories. These findings support the role of NR1D1 polymorphisms in the regulation of circadian rhythms.
authors: Department of Psychiatry and.
authors: Jee In
authors: JI
authors: Kang
authors: Chun Il
authors: CI
authors: Park
authors: Kee
authors: K
authors: Namkoong
authors: Se Joo
authors: SJ
authors: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm / Q000235:genetics*; D005260:Female; D015694:Gene Products, rev / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000235:genetics*; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D015694:Gene Products, rev; C064353:NR1D1 protein, human; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1
keywords: Association; NR1D1 gene; REV-ERBα; chronotype; circadian rhythm; genetics