title: Lack of association between JAK3 gene polymorphisms and cardiovascular disease in Spanish patients with rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.
authors: Institute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, 18016 Granada, Spain.
authors: Mercedes
authors: M
authors: García-Bermúdez
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Raquel
authors: R
authors: López-Mejías
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Fernanda
authors: 0000-0003-3612-1448
authors: F
authors: Genre
authors: Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, Spain.
authors: Santos
authors: S
authors: Castañeda
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Alfonso
authors: A
authors: Corrales
authors: Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiology and Public Health (CIBERESP), IDIVAL, 39011 Santander, Spain.
authors: Javier
authors: 0000-0002-9400-0989
authors: J
authors: Llorca
authors: Cardiology Division, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain.
authors: Carlos
authors: C
authors: González-Juanatey
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Begoña
authors: B
authors: Ubilla
authors: Division of Rheumatology, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain.
authors: José A
authors: JA
authors: Miranda-Filloy
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Trinitario
authors: T
authors: Pina
authors: Department of Rheumatology, Hospital Universitario Bellvitge, 08907 Barcelona, Spain.
authors: Carmen
authors: C
authors: Gómez-Vaquero
authors: Department of Rheumatology, Hospital Clínico San Carlos, 28040 Madrid, Spain.
authors: Luis
authors: L
authors: Rodríguez-Rodríguez
authors: Department of Rheumatology, Hospital Clínico San Carlos, 28040 Madrid, Spain.
authors: Benjamín
authors: B
authors: Fernández-Gutiérrez
authors: Department of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, Spain.
authors: Alejandro
authors: A
authors: Balsa
authors: Department of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, Spain.
authors: Dora
authors: D
authors: Pascual-Salcedo
authors: Department of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
authors: Francisco J
authors: FJ
authors: López-Longo
authors: Department of Rheumatology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain.
authors: Patricia
authors: P
authors: Carreira
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain.
authors: Ricardo
authors: R
authors: Blanco
authors: Institute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, 18016 Granada, Spain.
authors: Javier
authors: J
authors: Martín
authors: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, Spain ; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.
authors: Miguel A
authors: MA
authors: González-Gay
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000201:enzymology / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D059168:Carotid Intima-Media Thickness; D003710:Demography; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053616:Janus Kinase 3 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000378:metabolism; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000201:enzymology / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D002097:C-Reactive Protein; C507933:JAK3 protein, human; D053616:Janus Kinase 3