title: [The tip of the iceberg: cutaneous manifestations of paediatric diseases with neurological involvement].
abstract: BACKGROUND
  Some cutaneous lesions might be the first clinical manifestation of diseases with systemic involvement. This article aims to review the relevant dermatological semiology for the concerning diseases with neurological involvement in childhood.
  
  
  METHODS
  Review of the related literature indexed to MedLine published in the last twelve years.
  
  
  RESULTS
  The main relevant nosologic groups include the genodermatosis (namely neurocutaneous syndromes), pigmentary, vascular and endocrine disorders, congenital enzymatic deficiencies and occult spinal dysraphisms.
  
  
  CONCLUSIONS
  The recognition of specific cutaneous signs is important once may enable a much earlier diagnosis.
authors: Serviço de Dermatologia. Hospital S. António dos Capuchos. Centro Hospitalar de Lisboa Central. Lisboa. Portugal.
authors: Ana
authors: A
authors: Brasileiro
authors: Paula
authors: P
authors: Afonso
authors: Filipa
authors: F
authors: Diamantino
authors: Maria João
authors: MJ
authors: Paiva Lopes
mesh_terms: D002648:Child; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications* / Q000175:diagnosis; D009456:Neurofibromatosis 1 / Q000150:complications; D010859:Pigmentation Disorders / Q000209:etiology; D012871:Skin Diseases / Q000209:etiology*; D014402:Tuberous Sclerosis / Q000150:complications; D014652:Vascular Diseases / Q000150:complications