title: Molecular modeling based semi-synthesis and in vitro evaluation of anticancer activity in indolyl chalcones.
abstract: A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against four human cancer cell lines. Compounds 1a, 1b, 1d, 1f-1j, 2c, 2e, 2i showed significant cytotoxicity. Chalcones 1b and 1d were identified as the most potent and selective anticancer agents with IC50 values <1µg/ml and 1.51µg/ml, against WRL-68 cell line, respectively.
authors: Rashmi
authors: R
authors: Gaur
authors: Dharmendra K
authors: DK
authors: Yadav
authors: Shiv
authors: S
authors: Kumar
authors: M P
authors: MP
authors: Darokar
authors: Feroz
authors: F
authors: Khan
authors: Medicinal Chemistry Division CSIR-Central Institute of Medicinal and Aromatic Plants Lucknow-226015, India. bhakunirs2000@yahoo.com.
authors: Rajendra Singh
authors: RS
authors: Bhakuni