title: A new formula for estimation of low-density lipoprotein cholesterol in an ethnic Chinese population.
abstract: BACKGROUND
  Low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease and is usually estimated by the Friedewald formula (FF) calculated from three parameters, namely, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). We aimed to develop a new and simple formula (NF) for LDL-C estimation.
  
  
  METHODS
  This cross-sectional study enrolled two study populations (a testing group, n=16,749, and a validation group, n=4940). Linear regression analysis was used in the testing group to investigate the association between measured LDL-C (mLDL-C) and TC concentration, and was verified in the validation group.
  
  
  RESULTS
  The NF yielded an estimated LDL-C (eLDL-C) equal to 0.75 × total cholesterol-0.6465 (mmol/L). For the subjects with TC between 2.58 and 7.74 mmol/L, the difference between mLDL-C and eLDL-C using the NF was less than that from the FF (testing group: -0.04 to -0.20 vs. -0.28 to -0.38 mmol/L; validation group: 0.01 to -0.12 vs. -0.23 to -0.30 mmol/L; p<0.001, respectively). The predictability of the NF was not inferior to that of the FF in subjects with different triglyceride and HDL-C concentrations, and was not affected by diabetes diagnosis and statin use. However, the NF performed similar to or worse than the FF at TC concentrations <2.58 mmol/L and >7.74 mmol/L, respectively.
  
  
  CONCLUSIONS
  In the Chinese population, the accuracy of eLDL-C measurement with the NF was better than that with the FF, especially in subjects with TC levels between 2.58 and 7.74 mmol/L. The NF is simple and may be used for screening as well as for follow-up of patients on lipid lowering agents.
authors: Ching-Yun
authors: CY
authors: Hu
authors: Chia-Lin
authors: CL
authors: Lee
authors: Wayne H-H
authors: WH
authors: Sheu
authors: Jun-Sing
authors: JS
authors: Wang
authors: I-Te
authors: IT
authors: Lee
authors: Yuh-Min
authors: YM
authors: Song
authors: Chia-Po
authors: CP
authors: Fu
authors: Jiin-Tsae
authors: JT
authors: Ling
authors: Yu-Fen
authors: YF
authors: Li
authors: Shih-Yi
authors: SY
authors: Lin
mesh_terms: D044466:Asian People; D002681:China / Q000208:ethnology; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged
chemical_list: D008078:Cholesterol, LDL