title: Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity.
abstract: High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection.
authors: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
authors: Stefan
authors: S
authors: Harmsen
authors: Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.
authors: Matthew A
authors: MA
authors: Bedics
authors: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.|Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, United States.
authors: Matthew A
authors: MA
authors: Wall
authors: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.
authors: Ruimin
authors: R
authors: Huang
authors: Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260-3000, United States.
authors: Michael R
authors: MR
authors: Detty
authors: Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.|Center for Molecular Imaging and Nanotechnology (CMINT), Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States.|Department of Radiology, Weill Cornell Medical College, 445 East 69th Street, New York, New York 10021, United States.
authors: Moritz F
authors: MF
authors: Kircher
mesh_terms: D000327:Adsorption; D018011:Chalcogens / Q000138:chemical synthesis / Q000378:metabolism*; D004396:Coloring Agents / Q000138:chemical synthesis / Q000378:metabolism*; D006046:Gold / Q000378:metabolism*; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000378:metabolism*; D053768:Metal Nanoparticles; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013499:Surface Properties
chemical_list: D018011:Chalcogens; D004396:Coloring Agents; D006575:Heterocyclic Compounds, 3-Ring; D006046:Gold