title: Nanomaterial categorization for assessing risk potential to facilitate regulatory decision-making.
abstract: For nanotechnology to meet its potential as a game-changing and sustainable technology, it is important to ensure that the engineered nanomaterials and nanoenabled products that gain entry to the marketplace are safe and effective. Tools and methods are needed for regulatory purposes to allow rapid material categorization according to human health and environmental risk potential, so that materials of high concern can be targeted for additional scrutiny, while material categories that pose the least risk can receive expedited review. Using carbon nanotubes as an example, we discuss how data from alternative testing strategies can be used to facilitate engineered nanomaterial categorization according to risk potential and how such an approach could facilitate regulatory decision-making in the future.
authors: Hilary
authors: H
authors: Godwin
authors: Catherine
authors: C
authors: Nameth
authors: David
authors: D
authors: Avery
authors: Lynn L
authors: LL
authors: Bergeson
authors: #CEA Nanosafety Platform, Grenoble, France.
authors: Daniel
authors: D
authors: Bernard
authors: ¶Luskin School of Public Affairs, University of California, Los Angeles, California 90095, United States.
authors: Elizabeth
authors: E
authors: Beryt
authors: □Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
authors: William
authors: W
authors: Boyes
authors: Scott
authors: S
authors: Brown
authors: ○PETA International Science Consortium Ltd., London, United Kingdom.
authors: Amy J
authors: AJ
authors: Clippinger
authors: ●Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California 90095, United States.
authors: Yoram
authors: Y
authors: Cohen
authors: △Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, D.C. 20460, United States.
authors: Maria
authors: M
authors: Doa
authors: ▲Center for the Environmental Implications of Nanotechnology, Duke University, Durham, North Carolina 27708, United States.
authors: Christine Ogilvie
authors: CO
authors: Hendren
authors: ▽Bren School of Environmental Science and Management, University of California, Santa Barbara, California 93106, United States.
authors: Patricia
authors: P
authors: Holden
authors: □Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States.
authors: Keith
authors: K
authors: Houck
authors: ▼Brown University, Providence, Rhode Island 02912, United States.
authors: Agnes B
authors: AB
authors: Kane
authors: ⬡Pennsylvania Bio Nano Systems, Doylestown, Pennsylvania 18901, United States.
authors: Frederick
authors: F
authors: Klaessig
authors: ⬢Cabot Corporation, Boston, Massachusetts 02210, United States.
authors: Toivo
authors: T
authors: Kodas
authors: ††Experimental Toxicology and Ecology, BASF SE, 67056 Ludwigshafen am Rhein, Germany.
authors: Robert
authors: R
authors: Landsiedel
authors: Iseult
authors: I
authors: Lynch
authors: §§University of California School of Law, Los Angeles, California 90095, United States.
authors: Timothy
authors: T
authors: Malloy
authors: ⊥⊥Applied NanoStructured Solutions, L.L.C., Lockheed Martin Company, Baltimore, Maryland 21220, United States.
authors: Mary Beth
authors: MB
authors: Miller
authors: ##Nanocyl, Sambreville, Belgium.
authors: Julie
authors: J
authors: Muller
authors: ¶¶University of Rochester, Rochester, New York 14627, United States.
authors: Gunter
authors: G
authors: Oberdorster
authors: □□Material Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States.
authors: Elijah J
authors: EJ
authors: Petersen
authors: ■■Intertox, Inc., Seattle, Washington 98101, United States.
authors: Richard C
authors: RC
authors: Pleus
authors: △Office of Pollution Prevention and Toxics, U.S. Environmental Protection Agency, Washington, D.C. 20460, United States.
authors: Philip
authors: P
authors: Sayre
authors: ○○School of Life Sciences, Heriot-Watt University, Edinburgh EH14 4AS, United Kingdom.
authors: Vicki
authors: V
authors: Stone
authors: ●●Physicians Committee for Responsible Medicine, Washington, D.C. 20016, United States.
authors: Kristie M
authors: KM
authors: Sullivan
authors: △△Federal Institute for Risk Assessment, Berlin, Germany.
authors: Jutta
authors: J
authors: Tentschert
authors: ▲▲SouthWest NanoTechnologies, Norman, Oklahoma 73071, United States.
authors: Philip
authors: P
authors: Wallis
authors: Andre E
authors: AE
authors: Nel
mesh_terms: D000818:Animals; D003657:Decision Making; D004738:Engineering; D033161:Government Regulation; D006801:Humans; D036103:Nanotechnology / Q000331:legislation & jurisprudence*; D037742:Nanotubes, Carbon / Q000633:toxicity; D018570:Risk Assessment; D012449:Safety; D018675:Toxicity Tests; D014481:United States; D014484:United States Environmental Protection Agency / Q000331:legislation & jurisprudence
chemical_list: D037742:Nanotubes, Carbon