title: The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy.
abstract: OBJECTIVE
  Remarkable differences in weight loss have been observed in obese patients undergoing laparoscopic sleeve gastrectomy (LSG). These high variations might be partly explained by genetic factors. The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity. We aimed to explore the effects of the rs9939609 FTO gene polymorphism on weight loss among severely obese patients applying for LSG.
  
  
  METHODS
  All individuals were analyzed for the FTO rs9939609 gene polymorphism. A total of 74 morbid obese patients (20 male, 54 female) were operated. Body weight and body mass index (BMI) were measured at before LSG and after surgery at the sixth month.
  
  
  RESULTS
  Twenty-eight patients (37.8%) had genotype TT (wild-type allel), 36 patients (48.6%) had genotype TA, and 10 patients (13.5%) had genotype AA. In both wild-type group and mutant group, BMI and weight levels decreased at the sixth month after surgery. Percent of excess weight loss (EWL) at 6 months of follow-up was similar in both groups. There were no differences between the mutant and wild-type groups percent of EWL at the sixth month after applying LSG.
  
  
  CONCLUSIONS
  Our data showed that the rs9939609 FTO gene polymorphism is not a useful genetic test prior to LSG to help clinicians predicting the weight loss for severely obese patients in short-term follow-up.
authors: Department of Medical Genetics, Dr. Faruk Sükan Maternity and Pediatric Hospital, Konya, Turkey.
authors: Özgür
authors: Ö
authors: Balasar
authors: General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey. tugrul-cakir@hotmail.com.
authors: Tuğrul
authors: T
authors: Çakır
authors: Department of Medical Genetics, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey.
authors: Özgür
authors: Ö
authors: Erkal
authors: General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
authors: Arif
authors: A
authors: Aslaner
authors: Radiology Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, Turkey.
authors: Bülent
authors: B
authors: Çekiç
authors: Department of Public Health, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
authors: Mehmet
authors: M
authors: Uyar
authors: General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
authors: Nurullah
authors: N
authors: Bülbüller
authors: General Surgery Department, Antalya Training and Research Hospital, Muratpaşa, Antalya, 07000, Turkey.
authors: Mehmet Tahir
authors: MT
authors: Oruç
mesh_terms: D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D005260:Female; D005743:Gastrectomy; D005838:Genotype; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D015431:Weight Loss / Q000235:genetics*; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human
keywords: Laparoscopic sleeve gastrectomy; Weight loss; rs9939609 FTO gene polymorphism