title: Proteostatic hotspots in amyloid fibrils protect us from neurodegeneration.
abstract: Alzheimer's disease remains a formidable challenge for therapeutic management. In a recent report in Nature Structural and Molecular Biology, Cohen et al. (2015) present intriguing results showing that "designer" molecular chaperones may hold the key to an evolutionarily conserved program for management of toxic oligomer species contributing to brain pathobiology.
authors: The Scripps Research Institute, La Jolla, CA 92037, USA.
authors: Jay Kumar
authors: JK
authors: Singh
authors: The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: webalch@scripps.edu.
authors: William E
authors: WE
authors: Balch
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D018832:Molecular Chaperones / Q000502:physiology*; D066263:Protein Aggregation, Pathological
chemical_list: D016229:Amyloid beta-Peptides; D018832:Molecular Chaperones