title: CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese Han population.
abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss. Increasing evidence indicates that inflammation in the brain is a powerful factor in AD progression. Epoxyeicosatrienoic acids, the biologically active derivatives of arachidonic acid, synthesized by cytochrome P450 (CYP) epoxygenases, have been proven to have powerful anti-inflammatory effects. The aim of this study was to examine whether polymorphism in CYP2J2, encoding one of the most common CYP epoxygenase isoforms, is associated with late-onset AD (LOAD). This case-control study genotyped 672 representatives of the Chinese Han population, including 321 LOAD patients and 351 healthy controls matched for age and gender, for the functional rs890293 polymorphism within CYP2J2 by means of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The CYP2J2 rs890293 T allele and GT+TT genotype were significantly associated with an increased risk of LOAD. Further data stratification according to the presence of the apolipoprotein E (APOE) e4 allele confirmed a strong association between CYP2J2 rs890293 and LOAD, and indicated that the involvement of CYP2J2 in LOAD was independent of ApoE-ϵ4. Our study demonstrated that CYP2J2 rs890293 is a possible predisposing genetic factor for progression of LOAD.
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China; Laboratory of Molecular Biology, Center for Disease Control and Prevention of Guangzhou Military Command, Guangzhou 510507, China.
authors: Huacheng
authors: H
authors: Yan
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China; Department of Pharmacy, Guangzhou First People's Hospital, Guangzhou 510180, China.
authors: Yanying
authors: Y
authors: Kong
authors: Department of Pharmacy, Henan Cancer Hospital, Zhengzhou 450003, China.
authors: Baoxia
authors: B
authors: He
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Mukun
authors: M
authors: Huang
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Jian
authors: J
authors: Li
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Jiaqiang
authors: J
authors: Zheng
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Lei
authors: L
authors: Liang
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Jianjun
authors: J
authors: Bi
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors: Shujin
authors: S
authors: Zhao
authors: Department of Pharmacy, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. Electronic address: lucyshi622._921@163.com.
authors: Lei
authors: L
authors: Shi
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People; D016022:Case-Control Studies; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D053327:Apolipoprotein E4; C000717350:CYP2J2 protein, human; D003577:Cytochrome P-450 Enzyme System; D000090762:Cytochrome P-450 CYP2J2
keywords: Alzheimer’s disease; Apolipoprotein E; Cytochrome P450 2J2; Epoxyeicosatrienoic acids; Single nucleotide polymorphism