title: Regular aspirin use and stomach cancer risk in China.
abstract: OBJECTIVE
  Epidemiological studies on aspirin and stomach cancer have been inconclusive. The purpose of our study was to investigate the association between aspirin and stomach cancer in China.
  
  
  METHODS
  A 1:2 matched case-control study was conducted in four large medical centers. A self-designed questionnaire was used to collect information. Unconditional logistic regression was used to compute crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).
  
  
  RESULTS
  Our study indicated that risk of stomach cancer was greatly reduced for regular aspirin user (OR = 0.62; 95% CI 0.42-0.80). Specifically, dosage and tablet-years of use were associated with lower risk (OR = 0.54; 95% CI 0.29-0.84 for ≥7 tabs/week; OR = 0.47; 95% CI 0.32-0.81 for ≥10 tablet years, respectively). Furthermore, the finding was strengthened by stratified studies of gender, smoking status, body mass index (BMI) and helicobacter pylori.
  
  
  CONCLUSIONS
  Our study confirmed that regular aspirin use is a protective factor to stomach cancer.
authors: Department of Surgery, Liaoning Cancer Hospital and Institute, Shenyang, China. Electronic address: 13514212975@163.com.
authors: Y
authors: Y
authors: Wang
authors: Department of Surgery, The Second Hospital of Shenyang Medical College, Shenyang, China. Electronic address: chunjianshen@sina.com.
authors: C
authors: C
authors: Shen
authors: Department of Surgery, The First Hospital of China Medical University, Shenyang, China. Electronic address: jianniange@126.com.
authors: J
authors: J
authors: Ge
authors: Department of Epidemiology, Zhengzhou University, Zhengzhou, China. Electronic address: hongduan@126.com.
authors: H
authors: H
authors: Duan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D011795:Surveys and Questionnaires
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin
keywords: Aspirin; Case–control study; Epidemiology; Stomach cancer