title: (-)-Tarchonanthuslactone exerts a blood glucose-increasing effect in experimental type 2 diabetes mellitus.
abstract: A number of studies have proposed an anti-diabetic effect for tarchonanthuslactone based on its structural similarity with caffeic acid, a compound known for its blood glucose-reducing properties. However, the actual effect of tarchonanthuslactone on blood glucose level has never been tested. Here, we report that, in opposition to the common sense, tarchonanthuslactone has a glucose-increasing effect in a mouse model of obesity and type 2 diabetes mellitus. The effect is acute and non-cumulative and is present only in diabetic mice. In lean, glucose-tolerant mice, despite a slight increase in blood glucose levels, the effect was not significant.
authors: Laboratory of Cell Signaling, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-761 Campinas, São Paulo, Brazil. hbee_quimica@yahoo.com.br.
authors: Gabriela F P
authors: GF
authors: de Souza
authors: Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-971 Campinas, São Paulo, Brazil. luiztnovaes@gmail.com.
authors: Luiz F T
authors: LF
authors: Novaes
authors: Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-971 Campinas, São Paulo, Brazil. santanacma@gmail.com.
authors: Carolina M
authors: CM
authors: Avila
authors: Laboratory of Cell Signaling, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-761 Campinas, São Paulo, Brazil. lribeiro_bio@yahoo.com.br.
authors: Lucas F R
authors: LF
authors: Nascimento
authors: Laboratory of Cell Signaling, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-761 Campinas, São Paulo, Brazil. lavelloso.unicamp@gmail.com.
authors: Licio A
authors: LA
authors: Velloso
authors: Institute of Chemistry, University of Campinas, UNICAMP, C.P. 6154, CEP 13084-971 Campinas, São Paulo, Brazil. pilli@iqm.unicamp.br.
authors: Ronaldo A
authors: RA
authors: Pilli
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009765:Obesity / Q000378:metabolism*; D011753:Pyrones / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D011753:Pyrones; C427965:tarchonanthuslactone