title: Neonatal outcomes after early rescue intracytoplasmic sperm injection: an analysis of a 5-year period.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of early rescue intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Teaching hospital.
  
  
  METHODS
  There were 13,232 ovarian stimulation cycles (IVF, n = 9,631; ICSI, n = 2,871; early rescue ICSI, n = 730) that resulted in the delivery of 5,001 babies (IVF, n = 3,670; ICSI, n = 1,095; early rescue ICSI, n = 246) from August 2008 to August 2013.
  
  
  METHODS
  Early rescue ICSI.
  
  
  METHODS
  Clinical pregnancy rates, neonatal outcomes, and congenital birth defects were analyzed.
  
  
  RESULTS
  The early rescue ICSI cycles did not seem to have a negative effect on the clinical pregnancy rate (43.42%) when IVF cycles (45.33%) were compared with ICSI cycles (44.39%). In the early rescue ICSI group, a total of 254 clinical pregnancies were achieved: 197 (33.67%) live births, 38 (6.49%) miscarriages, 2 (0.79%) induced abortions, 3 (1.18%) fetal deaths, and 4 pregnancies (1.57%) without completion at follow-up. Overall, the multiple gestations, the delivery method, mean gestational age, preterm deliveries, mean birth weight, and rate of congenital birth defects of the early rescue ICSI group were similar to those in the conventional IVF and ICSI groups.
  
  
  CONCLUSIONS
  Early rescue ICSI had similar clinical pregnancy rates when compared with conventional IVF and ICSI, in addition to the delivery of healthy children. The clinical evidence from the early rescue ICSI group did not show an elevated rate of malformations. Early rescue ICSI seems to be a safe alternative method for individuals with total fertilization failure or near total fertilization failure when compared with conventional IVF treatment.
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Bo
authors: B
authors: Huang
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Kun
authors: K
authors: Qian
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Zhou
authors: Z
authors: Li
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Jing
authors: J
authors: Yue
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Wei
authors: W
authors: Yang
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors: Guijin
authors: G
authors: Zhu
authors: Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan, People's Republic of China. Electronic address: hamwond@gmail.com.
authors: Hanwang
authors: H
authors: Zhang
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data; D000022:Abortion, Spontaneous; D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000401:mortality*; D005260:Female; D046689:Fetal Mortality; D006801:Humans; D015994:Incidence; D007248:Infertility, Male / Q000401:mortality* / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D009099:Multiple Birth Offspring / Q000706:statistics & numerical data; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012307:Risk Factors; D016879:Salvage Therapy / Q000401:mortality*; D020554:Sperm Injections, Intracytoplasmic / Q000401:mortality*; D015996:Survival Rate; D016896:Treatment Outcome
keywords: Early rescue ICSI; IVF; congenital birth defects; neonatal outcome; total fertilization failure