title: Genetic testing for age-related macular degeneration: not indicated now.
abstract: Age-related macular degeneration is a very common condition that is caused by a complex interplay of genetic and environmental factors. It is likely that, in the future, genetic testing will allow physicians to achieve better clinical outcomes by administering specific treatments to patients based on their genotypes. However, improved outcomes for genotyped patients have not yet been demonstrated in a prospective clinical trial, and as a result, the costs and risks of routine genetic testing currently outweigh the benefits for patients with age-related macular degeneration.
authors: The University of Iowa Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Stephen A. Wynn Institute for Vision Research, Howard Hughes Medical Institute, Iowa City.
authors: Edwin M
authors: EM
authors: Stone
mesh_terms: D000047:Academies and Institutes; D000368:Aged; D000369:Aged, 80 and over; D017242:Complement Factor H / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D009885:Ophthalmology / Q000458:organization & administration; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D011506:Proteins / Q000235:genetics; D018570:Risk Assessment
chemical_list: C514392:ARMS2 protein, human; C493495:CFH protein, human; D011506:Proteins; D017242:Complement Factor H