title: Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications.
abstract: Bioorthogonal chemistry has recently emerged to be one of the most powerful tools in drug discovery and chemical biology. The exploration of it has successfully advanced the field of natural product research. In this Perspective, we survey current strategies for the installation of chemical handles into the molecular scaffolds of several major classes of natural products, including polyketides (PKs), non-ribosomal peptides (NRPs), and their hybrids. By tagging these natural products with chemical handles and coupling them with subsequent bioorthogonal reactions, researchers have visualized and studied the mode of action of natural products, as well as synthesized derivatives with better pharmaceutical properties. We conclude this Perspective by considering two questions: is there a general way to synthesize tagged PKs/NRPs? Does natural product labeling have a broader impact in the field of natural product research beyond current known applications?
authors: Department of Chemical and Biomolecular Engineering, University of California, Berkeley Berkeley, CA, USA ; Energy Biosciences Institute, University of California, Berkeley Berkeley, CA, USA.
authors: Xuejun
authors: X
authors: Zhu
authors: Department of Chemical and Biomolecular Engineering, University of California, Berkeley Berkeley, CA, USA ; Energy Biosciences Institute, University of California, Berkeley Berkeley, CA, USA ; Physical Biosciences Division, Lawrence Berkeley National Laboratory Berkeley, CA, USA.
authors: Wenjun
authors: W
authors: Zhang
keywords: alkyne-azide cycloaddition; bioorthogonal chemistry; biosynthesis; natural product labeling; non-ribosomal peptides; polyketides