title: Isoquinolone synthesis through S(N)Ar reaction of 2-halobenzonitriles with ketones followed by cyclization.
abstract: An efficient method for the synthesis of isoquinolones through base KO(t)Bu-promoted S(N)Ar reaction of 2-halobenzonitriles with ketones followed by Lewis acid Cu(OAc)2-catalyzed cyclization is described. Isoquinolone derivatives were obtained in satisfactory to good yields.
authors: †State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
authors: Muhammad Shareef
authors: MS
authors: Mayo
authors: †State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
authors: Xiaoqiang
authors: X
authors: Yu
authors: †State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
authors: Xiujuan
authors: X
authors: Feng
authors: †State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.|‡WPI-AIMR (WPI-Advanced Institute for Materials Research), Tohoku University, Sendai 980-8577, Japan.
authors: Yoshinori
authors: Y
authors: Yamamoto
authors: †State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
authors: Ming
authors: M
authors: Bao
mesh_terms: D001128:Argon / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006846:Hydrocarbons, Halogenated; D007659:Ketones; D009570:Nitriles; D015363:Quinolones; D001128:Argon; D003300:Copper