title: Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler.
abstract: The paper presents results of physico-chemical and biological investigations of a surface-engineered synthetic bone filler. Surface analysis confirms that the ceramic phosphate granules present a collagen nanolayer to the surrounding environment. Cell cultures tests show that, in agreement with literature reports, surface-immobilized collagen molecular cues can stimulate progression along the osteogenic pathway of undifferentiated human mesenchymal cells. Finally, in vivo test in a rabbit model of critical bone defects shows statistically significant increase of bone volume and mineral apposition rate between the biomimetic bone filler and collagen-free control. All together, obtained data confirm that biomolecular surface engineering can upgrade the properties of implant device, by promoting more specific and targeted implant-host cells interactions.
authors: Nobil Bio Ricerche Srl, Via Valcastellana 26, 14037, Portacomaro, AT, Italy.
authors: Marco
authors: M
authors: Morra
authors: Gianluca
authors: G
authors: Giavaresi
authors: Maria
authors: M
authors: Sartori
authors: Andrea
authors: A
authors: Ferrari
authors: Annapaola
authors: A
authors: Parrilli
authors: Daniele
authors: D
authors: Bollati
authors: Ruggero Rodriguez Y
authors: RR
authors: Baena
authors: Clara
authors: C
authors: Cassinelli
authors: Milena
authors: M
authors: Fini
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry* / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005264:Femoral Fractures / Q000473:pathology / Q000628:therapy*; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D013499:Surface Properties; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite