title: Large Cell Neuroendocrine Carcinoma of the Ovary and Its Skin Metastases: A Case Report and Review of the Literature.
abstract: Large cell neuroendocrine carcinoma in the gynaecological organs affects the uterine cervix and ovary. Large cell neuroendocrine carcinoma of the ovary is extremely rare, and prognosis is quite poor even when diagnosed at an early stage. These tumours respond poorly to standard chemotherapy regimens. The clinical observation of skin metastasis in patients with epithelial ovarian cancer is relatively uncommon, occurring in only 3.5% of patients. These lesions are observed mostly in skin of the abdominal wall adjacent to the primary ovarian tumours. Metastatic skin lesions on extremities are much more rare; it is reported that only 12% of epithelial ovarian carcinoma skin metastases occur on the limbs. Skin metastasis due to large cell neuroendocrine carcinoma of the ovary has not been previously reported. We report the case of a large cell neuroendocrine tumour of the ovary with skin metastases on extremities appearing two months after surgery in a 68-year old woman.
authors: Department of Medical Oncology, Kent Hospital, 8229/1, No. 56, Cigli 35630, Izmir, Turkey.|Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University, 35340 Inciralti, Izmir, Turkey. sunacok@gmail.com.
authors: S
authors: S
authors: Cokmert
authors: Department of Medical Oncology, Aydin State Hospital, Aydin, Turkey.
authors: L
authors: L
authors: Demir
authors: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors: L
authors: L
authors: Doganay
authors: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors: N
authors: N
authors: Demir
authors: Department of Nuclear Medicine, EgeRad Imaging Center, Izmir, Turkey.
authors: K
authors: K
authors: Kocacelebi
authors: Department of Medical Oncology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
authors: I T
authors: IT
authors: Unek
authors: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors: E
authors: E
authors: Gezer
authors: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors: K
authors: K
authors: Kilic
authors: Department of Medical Oncology, Kent Hospital, Izmir, Turkey.
authors: M
authors: M
authors: Alakavuklar