title: SDF1-3'A polymorphism is associated with size but not occurrence of abdominal aortic aneurysm in a Chinese population.
abstract: OBJECTIVE
  Previous studies have suggested that stromal-derived factor 1 (SDF1) plays a pivotal role in abdominal aortic aneurysm (AAA) development. The SDF1-3'A polymorphism (G to A, rs1801157), located in the 3' untranslated region, could influence the expression of SDF1. The aim of our study was to investigate the relationship of SDF1-3'A polymorphism with the risk of AAA occurrence and size.
  
  
  METHODS
  A total of 205 AAA patients and 216 age- and sex-matched controls were recruited. The SDF1-3'A polymorphism was evaluated by polymerase chain reaction, followed by restriction enzyme analysis.
  
  
  RESULTS
  The frequency of A allele was similar between groups. The genotype distribution also displayed no statistically significant differences under both the dominant model (odds ratio [OR], 0.922; P = .678) and the recessive model (OR, 1.617; P = .300). The multiple logistic regression analysis indicated that the association between the polymorphism and AAA remained insignificant when applied to the dominant model. However, AAA patients with GG genotype were more likely to develop aneurysms larger than 50 mm (OR, 0.497; P = .014). AAA patients with SDF1-3'A allele have reduced plasma SDF1α levels. In addition, plasma SDF1α levels were positively correlated with AAA size.
  
  
  CONCLUSIONS
  Our study suggests that SDF1-3'A polymorphism is associated with size but not occurrence of AAA, providing further evidence that SDF1 is implicated in AAA progression.
authors: Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors: Wenwen
authors: W
authors: Zhang
authors: Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors: Zhao
authors: Z
authors: Liu
authors: Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
authors: Min
authors: M
authors: Zhou
authors: Center for Translational Medicine, Nanjing University Medical School, Nanjing, China.
authors: Long
authors: L
authors: Yi
authors: Department of Vascular Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: dr_cjliu@hotmail.com.
authors: Changjian
authors: C
authors: Liu
mesh_terms: D020413:3' Untranslated Regions; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000208:ethnology / Q000235:genetics*; D001027:Aortography / Q000379:methods; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D016009:Chi-Square Distribution; D002681:China; D000072226:Computed Tomography Angiography; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D020413:3' Untranslated Regions; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12