title: Endoplasmic reticulum quality control in cancer: Friend or foe.
abstract: Quality control systems in the endoplasmic reticulum (ER) mediated by unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) ensure cellular function and organismal survival. Recent studies have suggested that ER quality-control systems in cancer cells may serve as a double-edged sword that aids progression as well as prevention of tumor growth in a context-dependent manner. Here we review recent advances in our understanding of the complex relationship between ER proteostasis and cancer pathology, with a focus on the two most conserved ER quality-control mechanisms--the IRE1α-XBP1 pathway of the UPR and SEL1L-HRD1 complex of the ERAD.
authors: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, United States.
authors: Hana
authors: H
authors: Kim
authors: Graduate Program in Genetics Genomics and Development, Cornell University, Ithaca, NY 14853, United States.
authors: Asmita
authors: A
authors: Bhattacharya
authors: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, United States; Graduate Program in Genetics Genomics and Development, Cornell University, Ithaca, NY 14853, United States. Electronic address: lq35@cornell.edu.
authors: Ling
authors: L
authors: Qi
mesh_terms: D000818:Animals; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D060746:Endoplasmic Reticulum-Associated Degradation; D004722:Endoribonucleases / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006706:Homeostasis; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy*; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D000071701:Regulatory Factor X Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D056811:Unfolded Protein Response; D000071717:X-Box Binding Protein 1
chemical_list: D004268:DNA-Binding Proteins; D011506:Proteins; D000071701:Regulatory Factor X Transcription Factors; C117384:SEL1L protein, human; D014157:Transcription Factors; D000071717:X-Box Binding Protein 1; C000605543:XBP1 protein, human; C000605544:Xbp1 protein, mouse; C482345:SYVN1 protein, human; D044767:Ubiquitin-Protein Ligases; C528229:ERN1 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases
keywords: ERAD; IRE1α-XBP1; Protein folding; SEL1L–HRD1; UPR