title: Formulation, characterization, and evaluation of ligand-conjugated biodegradable quercetin nanoparticles for active targeting.
abstract: The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and in vitro release studies were also performed. The MTT assay was performed against two different cell lines, to measure their anticancer potentials and their targeting ability. The study thus reveals that MA-Qu-PLGA and FA-Qu-PLGA nanoparticles (NPs) can be used as effective drug delivery systems for skin cancer treatment encompassing natural drugs.
authors: a University Institute of Pharmacy, Pt.Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors: Anshita
authors: A
authors: Gupta
authors: a University Institute of Pharmacy, Pt.Ravishankar Shukla University , Raipur , Chhattisgarh , India.|b Shri Rawatpura Sarkar Institute of Pharmacy , Kumhari, Dist-Durg , Chhattisgarh , India.
authors: Chanchal Deep
authors: CD
authors: Kaur
authors: a University Institute of Pharmacy, Pt.Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors: Shailendra
authors: S
authors: Saraf
authors: a University Institute of Pharmacy, Pt.Ravishankar Shukla University , Raipur , Chhattisgarh , India.
authors: Swarnlata
authors: S
authors: Saraf
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011794:Quercetin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D011794:Quercetin
keywords: MTT assay; folate; mannose; nanoparticles; response surface methodology; targeted drug delivery