title: Stress-responsive factor regulation in patients suffering from type 2 diabetes and myocardial infarction.
abstract: OBJECTIVE
  Pro-free radical oxidative stresses, as well as regulatory factors, are believed to be the key players in the development of diabetes and heart-related disorders such as myocardial infarction. The aim of the present study was to highlight the role of oxidative stress-responsive factors (reactive oxygen species [ROS], super oxide dismutase [SOD], and calpain-1) in type 2 diabetes and myocardial infarction.
  
  
  METHODS
  A total of 100 type 2 diabetes patients with myocardial infarction and 50 normal individuals were selected for this analysis. The levels of ROS and activities of SOD in the serum were determined. Serum calpain-1 expression was checked using western blotting.
  
  
  RESULTS
  The serum level of ROS and the expression of calpain-1 were significantly higher while the activity of SOD was significantly lower in diabetic patients with myocardial infraction compared to normal individuals.
  
  
  CONCLUSIONS
  These findings suggest a possible link between decreased antioxidant (SOD) and increased ROS levels as well as calpain-1 expression, supporting the role of oxidative stress-regulatory factors in diabetes and myocardial infraction.
authors: Sobia
authors: S
authors: Mushtaq
authors: Tahir
authors: T
authors: Ali
authors: Farhana
authors: F
authors: Altaf
authors: Muhammad
authors: M
authors: Abdullah
authors: Iram
authors: I
authors: Murtaza
mesh_terms: D002154:Calpain; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D002154:Calpain