title: Comorbidities against quality control of VKA therapy in non-valvular atrial fibrillation: a French national cross-sectional study.
abstract: BACKGROUND
  Given the prevalence of non-valvular atrial fibrillation in the geriatric population, thromboembolic prevention by means of vitamin K antagonists (VKA) is one of the most frequent daily concerns of practitioners. The effectiveness and safety of treatment with VKA correlates directly with maximizing the time in therapeutic range, with an International Normalized Ratio (INR) of 2.0-3.0. The older population concentrates many of factors known to influence INR rate, particularly concomitant medications and concurrent medical conditions, also defined as comorbidities.
  
  
  OBJECTIVE
  Determine whether a high burden on comorbidities, defined by a Charlson Comorbidity Index (CCI) of 3 or greater, is associated a lower quality of INR control.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  French geriatric care units nationwide.
  
  
  METHODS
  2164 patients aged 80 and over and treated with vitamin K antagonists.
  
  
  METHODS
  Comorbidities were assessed using the Charlson Comorbidity Index (CCI). The recorded data included age, sex, falls, kidney failure, hemorrhagic event, VKA treatment duration, and the number and type of concomitant medications. Quality of INR control, defined as time in therapeutic range (TTR), was assessed using the Rosendaal method.
  
  
  RESULTS
  487 patients were identified the low-quality control of INR group. On multivariate logistic regression analysis, low-quality control of INR was independently associated with a CCI ≥3 (OR = 1.487; 95% CI [1.15; 1.91]). The other variables associated with low-quality control of INR were: hemorrhagic event (OR = 3.151; 95% CI [1.64; 6.07]), hospitalization (OR = 1.614, 95% CI [1.21; 2.14]).
  
  
  CONCLUSIONS
  An elevated CCI score (≥3) was associated with low-quality control of INR in elderly patients treated with VKA. Further research is needed to corroborate this finding.
authors: Department of Geriatrics, EA 1156-12, Nantes University Hospital, Nantes, France.
authors: Agnes
authors: A
authors: Rouaud
authors: Department of Geriatrics, Broca Hospital, Public Hospital of Paris, Paris, France.
authors: Olivier
authors: O
authors: Hanon
authors: Department of Geriatrics, EA 1156-12, Nantes University Hospital, Nantes, France.
authors: Anne-Sophie
authors: AS
authors: Boureau
authors: Guillaume
authors: G
authors: Chapelet
authors: Department of Geriatrics, EA 1156-12, Nantes University Hospital, Nantes, France.
authors: Guillaume Gilles
authors: GG
authors: Chapelet
authors: Department of Geriatrics, EA 1156-12, Nantes University Hospital, Nantes, France.
authors: Laure
authors: L
authors: de Decker
mesh_terms: D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000188:drug therapy*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005602:France; D006801:Humans; D019934:International Normalized Ratio; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D011786:Quality Control; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D014812:Vitamin K