title: Default mode network dissociation in depressive and anxiety states.
abstract: The resting state brain networks, particularly the Default Mode Network (DMN), have been found to be altered in several psychopathological conditions such as depression and anxiety. In this study we hypothesized that cortical areas of the DMN, particularly the anterior regions--medial prefrontal cortex and anterior cingulate cortex--would show an increased functional connectivity associated with both anxiety and depression. Twenty-four healthy participants were assessed using Hamilton Depression and Anxiety Rating Scales and completed a resting-state functional magnetic resonance imaging scan. Multiple regression was performed in order to identify which areas of the DMN were associated with anxiety and depression scores. We found that the functional connectivity of the anterior portions of DMN, involved in self-referential and emotional processes, was positively correlated with anxiety and depression scores, whereas posterior areas of the DMN, involved in episodic memory and perceptual processing were negatively correlated with anxiety and depression scores. The dissociation between anterior and posterior cortical midline regions, raises the possibility of a functional specialization within the DMN in terms of self-referential tasks and contributes to the understanding of the cognitive and affective alterations in depressive and anxiety states.
authors: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal. joanafpc@gmail.com.
authors: Joana Fernandes
authors: JF
authors: Coutinho
authors: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
authors: Sara Veiga
authors: SV
authors: Fernandesl
authors: Life and Health Sciences Research Institute and ICVS-3Bs PT Government Associate Laboratory, Universityof Minho, Braga, Portugal.
authors: José Miguel
authors: JM
authors: Soares
authors: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
authors: Liliana
authors: L
authors: Maia
authors: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.|Department of Counseling and Applied Educational Psychology, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.|Spaulding Neuromodulation Center, Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Boston, MA, USA.|Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: Óscar Filipe
authors: ÓF
authors: Gonçalves
authors: Neuropsychophysiology Lab, CIPsi, School of Psychology, University of Minho, Braga, Portugal.
authors: Adriana
authors: A
authors: Sampaio
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003863:Depression / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis; D012146:Rest; D055815:Young Adult
keywords: Anterior-posterior dissociation; Anxiety states; Default mode network; Depressive states