title: Remarkable regression of massive deep vein thrombosis in response to intensive oral rivaroxaban treatment.
abstract: Deep vein thrombosis (DVT) is a common disease and is associated with pulmonary embolism (PE). Proximal iliofemoral DVT may lead to severe PE and chronic venous insufficiency. The standard therapy for DVT is anticoagulant therapy using heparin and a vitamin K antagonist, but a recent clinical study showed that rivaroxaban, an oral Xa inhibitor, was comparable to standard therapy and had less bleeding complications. Intensive high-dose anticoagulation is recommended during the initial 3 weeks of DVT treatment. The present report describes a case of a 77-year-old male showing a remarkable regression of DVT in response to rivaroxaban treatment within the initial 3 weeks of therapy and who did not experience any adverse events. His DVT was massive and was accompanied by proximal iliofemoral vein thrombus and iliac vein compression syndrome. Rivaroxaban, especially in intensive high-dose treatment, might be a safe and effective therapeutic choice for massive DVT.
authors: Department of Medicine and Biological Sciences, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511 Japan.
authors: Norimichi
authors: N
authors: Koitabashi
authors: Department of Cardiovascular Medicine, Maebashi Red Cross Hospital, Maebashi, Gunma Japan.
authors: Nogiku
authors: N
authors: Niwamae
authors: Department of Internal Medicine, Fukaya Red Cross Hospital, Fukaya, Saitama Japan.
authors: Tetsuya
authors: T
authors: Taguchi
authors: Department of Medicine and Biological Sciences, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511 Japan.
authors: Yoshiaki
authors: Y
authors: Ohyama
authors: Department of Medicine and Biological Sciences, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511 Japan.
authors: Noriaki
authors: N
authors: Takama
authors: Department of Medicine and Biological Sciences, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511 Japan.
authors: Masahiko
authors: M
authors: Kurabayashi
keywords: Anticoagulation; Deep vein thrombosis; Iliac vein compression; Rivaroxaban; Thrombus regression