title: [Contribution of non-HLA genes to juvenile idiopathic arthritis susceptibility].
abstract: Juvenile idiopathic arthritis (JAL4) is the most common chronic rheumatologic disease in children. JIA is a group of disorders that share the clinical manifestation of chronic joint inflammation. The Human Leukocyte Antigen region (HLA) seems to be a major susceptibility locus for JIA that is estimated to account for 17% of familial segregation of the disease. Genome-wide association studies (GWAS), case-control studies and meta-analyses of the post-GWAS era revealed over 20 non-HLA loci conferring susceptibility to JIA. At least a half of those are shared between JIA and rheumatoid arthritis, an adult rheumatic disease, thereby suggesting for similarity of pathogenic mechanisms of both diseases. New findings also suggest for a likely role of epigenetic alterations in the pathogenesis of JIA that should be investigated in the future.
authors: K V
authors: KV
authors: Savost'anov
authors: E I
authors: EI
authors: Alexeeva
authors: D A
authors: DA
authors: Chistiakov
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000235:genetics; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10; D002893:Chromosomes, Human, Pair 3; D002894:Chromosomes, Human, Pair 4; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics; D008285:Major Histocompatibility Complex / Q000235:genetics; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22 / Q000235:genetics; D050797:STAT4 Transcription Factor / Q000235:genetics; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1 / Q000235:genetics
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human; D060907:V-Set Domain-Containing T-Cell Activation Inhibitor 1; C475826:VTCN1 protein, human; C516765:PTPN22 protein, human; D054596:Protein Tyrosine Phosphatase, Non-Receptor Type 22