title: A novel three-filament model of force generation in eccentric contraction of skeletal muscles.
abstract: We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.
authors: Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.
authors: Gudrun
authors: G
authors: Schappacher-Tilp
authors: Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.
authors: Timothy
authors: T
authors: Leonard
authors: Department of Mathematics and Scientific Computing, University of Graz, 8010 Graz, Austria.
authors: Gertrud
authors: G
authors: Desch
authors: Human Performance Laboratory, University of Calgary, Calgary, Alberta, Canada.
authors: Walter
authors: W
authors: Herzog
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D001696:Biomechanical Phenomena; D064211:Connectin / Q000378:metabolism; D008954:Models, Biological; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*
chemical_list: D064211:Connectin