title: Shear wave elastography plaque characterization with mechanical testing validation: a phantom study.
abstract: Determining plaque vulnerability is critical when selecting the most suitable treatment for patients with atherosclerotic plaque. Currently, clinical non-invasive ultrasound-based methods for plaque characterization are limited to visual assessment of plaque morphology and new quantitative methods are needed. In this study, shear wave elastography (SWE) was used to characterize hard and soft plaque mimicking inclusions in six common carotid artery phantoms by using phase velocity analysis in static and dynamic environments. The results were validated with mechanical tensile testing. In the static environment, SWE measured a mean shear modulus of 5.8 ± 0.3 kPa and 106.2 ± 17.2 kPa versus 3.3 ± 0.5 Pa and 98.3 ± 3.4 kPa measured by mechanical testing in the soft and hard plaques respectively. Furthermore, it was possible to measure the plaques' shear moduli throughout a simulated cardiac cycle. The results show good agreement between SWE and mechanical testing and indicate the possibility for in vivo arterial plaque characterization using SWE.
authors: Department of Medical Engineering, School of Technology and Health, KTH Royal Institute of Technology, 114 28 Stockholm, Sweden. Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Solna, Sweden.
authors: E
authors: E
authors: Widman
authors: E
authors: E
authors: Maksuti
authors: D
authors: D
authors: Larsson
authors: M W
authors: MW
authors: Urban
authors: A
authors: A
authors: Bjällmark
authors: M
authors: M
authors: Larsson
mesh_terms: D000465:Algorithms; D032701:Biomimetics; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D019047:Phantoms, Imaging; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D033081:Shear Strength; D013314:Stress, Mechanical