title: Vascular actions of 20-HETE.
abstract: 20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a myriad of biological effects in the vascular system. This review discusses the current knowledge related to the effects of 20-HETE on vascular reactivity, activation, and remodeling, as well as its role in vascular inflammation and angiogenesis. The information explaining how 20-HETE and the renin-angiotensin system interact to promote hypertension, vasoconstriction, and vascular dysfunction is summarized in this article. 20-HETE enhances vascular inflammation and injury in models of diabetes, ischemia/reperfusion, and cerebrovascular oxidative stress. Recent studies also established a role for 20-HETE in normal and pathological angiogenesis conditions. This review will also discuss the molecular mechanisms through which 20-HETE induces these vascular actions. Potential additional studies are suggested to address shortcomings in the current knowledge of 20-HETE in the vascular system.
authors: Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
authors: Samantha L
authors: SL
authors: Hoopes
authors: Department of Pharmacology, New York Medical College, Valhalla, NY, USA.
authors: Victor
authors: V
authors: Garcia
authors: Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.
authors: Matthew L
authors: ML
authors: Edin
authors: Department of Pharmacology, New York Medical College, Valhalla, NY, USA.
authors: Michal L
authors: ML
authors: Schwartzman
authors: Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address: zeldin@niehs.nih.gov.
authors: Darryl C
authors: DC
authors: Zeldin
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism*; D018919:Neovascularization, Physiologic; D012084:Renin-Angiotensin System; D014652:Vascular Diseases / Q000378:metabolism / Q000473:pathology; D066253:Vascular Remodeling
chemical_list: D006893:Hydroxyeicosatetraenoic Acids; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid
keywords: 20-HETE; Angiogenesis; Renin-angiotensin system; Vascular dysfunction; Vascular inflammation; Vascular remodeling