title: Antimicrobial prophylaxis for external ventricular drains in pediatric neurosurgical patients.
abstract: BACKGROUND
  Our goal was to describe the use of antibiotics for surgical prophylaxis of external ventricular drains (EVDs) in a pediatric neurosurgical population and determine the incidence of EVD-related infections among different antimicrobial prophylaxis strategies.
  
  
  METHODS
  This retrospective chart review included patients up to 18 years old who underwent EVD insertion at either of two tertiary care academic hospitals in the same health system between August 1, 2008, and July 31, 2012. Patients were included if they received at least one dose of antibiotics before EVD insertion. Patients who received only perioperative antibiotics were compared with those who also received antibiotics after this period. The primary endpoint was incidence of EVD-related infection. Descriptive statistics were used to summarize baseline characteristics and compare antibiotic regimens between groups. Pearson's chi square and Mann Whitney U tests compared nonparametric data.
  
  
  RESULTS
  A total of 182 EVD insertions were documented, and 88 included in the study. Of these 88, 27 were associated only with perioperative doses of antibiotics, and 61 with prolonged antibiotic use. Baseline characteristics and antibiotic choices were similar between the groups. At least 55 (63%) catheters were antibiotic-impregnated, but types of catheters couldn't be compared between groups due to insufficient data. No central nervous system infections were identified in either group, so the primary objective could not be evaluated statistically.
  
  
  CONCLUSIONS
  No infections were identified in any study subjects during EVD treatment. An adequately powered, multi-center prospective study should be performed to determine if prolonged use of antibiotics beyond the perioperative period is of benefit.
authors: Department of Pharmacy, Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA, anpete2@gmail.com.
authors: Amanda P
authors: AP
authors: Ifeachor
authors: Kristen R
authors: KR
authors: Nichols
authors: Jennifer L
authors: JL
authors: Morris
authors: Elaine G
authors: EG
authors: Cox
authors: Jodi L
authors: JL
authors: Smith
authors: Elizabeth A
authors: EA
authors: Sinclair
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods*; D002494:Central Nervous System Infections / Q000517:prevention & control; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents