title: Casein/pectin nanocomplexes as potential oral delivery vehicles.
abstract: Delivery systems prepared with natural biopolymers are of particular interests for applications in food, pharmaceutics and biomedicine. In this study, nanocomplex particles of sodium caseinate (NaCas) and pectin were fabricated and investigated as potential oral delivery vehicles. Nanocomplexes were prepared with three mass ratios of NaCas/pectin by acidification using glucono-δ-lactone and thermal treatment. NaCas/pectin at 1:1 mass ratio resulted in dispersions with the lowest turbidity and the smallest and most uniform nanocomplexes. Thermal treatment at 85 °C for 30 min facilitated the formation of stable, compact, and spherical nanocomplexes. Heating not only greatly increased the yield of nanocomplexes but also significantly improved the encapsulation capability of rutin studied as a model compound. Pectin in nanocomplexes delayed the hydrolysis of NaCas by pepsin at gastric conditions and enabled the controlled release of most rutin in simulated intestinal conditions. The nanocomplexes based on food-sourced biopolymers have promising features for oral delivery of nutrients and medicines.
authors: Department of Food Science and Technology, University of Tennessee, 2510 River Drive, Knoxville, TN 37996, United States; Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, United States. Electronic address: yangchao.luo@uconn.edu.
authors: Yangchao
authors: Y
authors: Luo
authors: Department of Food Science and Technology, University of Tennessee, 2510 River Drive, Knoxville, TN 37996, United States.
authors: Kang
authors: K
authors: Pan
authors: Department of Food Science and Technology, University of Tennessee, 2510 River Drive, Knoxville, TN 37996, United States. Electronic address: qzhong@utk.edu.
authors: Qixin
authors: Q
authors: Zhong
mesh_terms: D002364:Caseins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005942:Gluconates / Q000737:chemistry; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010194:Pancreatin / Q000737:chemistry; D010368:Pectins / Q000737:chemistry*; D010434:Pepsin A / Q000737:chemistry; D012431:Rutin / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D002364:Caseins; D004337:Drug Carriers; D005942:Gluconates; D007783:Lactones; D012431:Rutin; D010194:Pancreatin; D010368:Pectins; D010434:Pepsin A; C106477:glucono-1,4-lactone
keywords: Casein; Delayed gastric digestion; Nanocomplexes; Oral delivery vehicles; Pectin