title: Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer.
abstract: The Asn118Asn (rs11615) variant in theERCC1gene, and the Lys751Gln (rs13181) and Asp312Asn (rs1799793) variants in theERCC2gene have been associated with the development of varied types of cancer. The aim of the present study was to test for any association between theERCC1andERCC2gene variants and three different types of cancer in Mexican-mestizo patients. Patients and their respective controls were formed into three groups: The osteosarcoma group, with 28 patients and 97 controls; the colorectal group, with 108 patients and 119 controls; and the breast cancer group, with 71 patients and 74 controls. Genotyping was performed using TaqMan probes and quantitative polymerase chain reaction. Allele and genotype frequencies were compared using a χ2test. Only one SNP (rs1799793) was found to be associated with breast cancer. This is the first study analyzing the SNPs inERCC1andERCC2genes and the susceptibility to cancer in Mexican-mestizo patients with osteosarcoma, and colorectal and breast cancer.
authors: National Institute of Rehabilitation, México City, México.
authors: Benjamín
authors: B
authors: Gómez-Díaz
authors: Institute of Human Genetics, UCHS, University of Guadalajara, Wet Saw, Guadalajara, México.
authors: María
authors: M
authors: DE LA Luz Ayala-Madrigal
authors: Department of Clinics, UCALTOS, University of Guadalajara, Tepatitlán, Jalisco, México.
authors: Melva
authors: M
authors: Gutiérrez-Angulo
authors: National Medical Centre '20th November,' Institute for Social Security of State Workers, México City, México.
authors: Aura Erazo
authors: AE
authors: Valle-Solis
authors: National Institute of Rehabilitation, México City, México.
authors: Luis Miguel
authors: LM
authors: Linares-González
authors: National Institute of Rehabilitation, México City, México.
authors: Roberto
authors: R
authors: González-Guzmán
authors: National Institute of Rehabilitation, México City, México.
authors: David
authors: D
authors: Cruz-Guillén
authors: National Institute of Rehabilitation, México City, México.
authors: Ana Lilia
authors: AL
authors: Cedeño-Garcidueñas
authors: Obesity Research Unit, Faculty of Medicine, National Autonomous University of Mexico, México City, México.
authors: Patricia
authors: P
authors: Canto
authors: National Medical Centre '20th November,' Institute for Social Security of State Workers, México City, México.
authors: Luz Berenice
authors: LB
authors: López-Hernández
keywords: ERCC1; ERCC2; Mexican-mestizos; cancer