title: Usefulness of Somatostatin Receptor Scintigraphy (Tc-[HYNIC, Tyr3]-Octreotide) and 123I-Metaiodobenzylguanidine Scintigraphy in Patients with SDHx Gene-Related Pheochromocytomas and Paragangliomas Detected by Computed Tomography.
abstract: OBJECTIVE
  The aim of this study was to assess the usefulness of somatostatin receptor scintigraphy (SRS) using (99m)Tc-[HYNIC, Tyr3]-octreotide (TOC) and 123I-metaiodobenzylguanidine (mIBG) in patients with SDHx-related syndromes in which paragangliomas were detected by computed tomography and to establish an optimal imaging diagnostic algorithm in SDHx mutation carriers.
  
  
  METHODS
  All carriers with clinical and radiological findings suggesting paragangliomas were screened by SRS and 123I-mIBG. Lesions were classified by body regions, i.e. head and neck, chest, abdomen with pelvis and adrenal gland as well as metastasis.
  
  
  RESULTS
  We evaluated 46 SDHx gene mutation carriers (32 index cases and 14 relatives; 28 SDHD, 16 SDHB and 2 SDHC). In this group, 102 benign tumors were found in 39 studied patients, and malignant disease was diagnosed in 7 patients. In benign tumors, the sensitivity of SRS was estimated at 77% and of 123I-mIBG at 22.0%. The SRS and mIBG sensitivity was found to be clearly region dependent (p < 0.001). The highest SRS sensitivity was found in head and neck paragangliomas (HNP; 91.4%) and the lowest was found in abdominal paragangliomas and pheochromocytomas (40 and 42.9%, respectively). The highest 123I-mIBG sensitivity was found in pheochromocytomas (sensitivity of 100%) and the lowest in HNP (sensitivity of 3.7%). In metastatic disease, SRS was superior to mIBG (sensitivity of 95.2 vs. 23.8%, respectively).
  
  
  CONCLUSIONS
  SRS and 123I-mIBG single photon emission computed tomography (SPECT) sensitivity in SDHx patients is highly body region dependent. In malignant tumors, SRS is superior to 123I-mIBG SPECT.
authors: Department of Radiology, Institute of Cardiology, Warsaw, Poland.
authors: Ilona
authors: I
authors: Michałowska
authors: Jarosław B
authors: JB
authors: Ćwikła
authors: Mariola
authors: M
authors: Pęczkowska
authors: Mariusz I
authors: MI
authors: Furmanek
authors: John R
authors: JR
authors: Buscombe
authors: Wojciech
authors: W
authors: Michalski
authors: Aleksander
authors: A
authors: Prejbisz
authors: Małgorzata
authors: M
authors: Szperl
authors: Angelica
authors: A
authors: Malinoc
authors: Dariusz
authors: D
authors: Moczulski
authors: Zbigniew
authors: Z
authors: Szutkowski
authors: Andrzej
authors: A
authors: Kawecki
authors: Jolanta
authors: J
authors: Antoniewicz
authors: Piotr
authors: P
authors: Pęczkowski
authors: Anna
authors: A
authors: Lewczuk
authors: Maciej
authors: M
authors: Otto
authors: Andrzej
authors: A
authors: Cichocki
authors: Grażyna
authors: G
authors: Bednarek-Tupikowska
authors: Marek
authors: M
authors: Kabat
authors: Hanna
authors: H
authors: Janaszek-Sitkowska
authors: Katarzyna
authors: K
authors: Przybyłowska
authors: Jadwiga
authors: J
authors: Janas
authors: Hartmut P H
authors: HP
authors: Neumann
authors: Andrzej
authors: A
authors: Januszewicz
mesh_terms: D019797:3-Iodobenzylguanidine; D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015282:Octreotide; D010235:Paraganglioma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D010673:Pheochromocytoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000235:genetics; D011446:Prospective Studies; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013667:Technetium; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin; D019797:3-Iodobenzylguanidine; D013667:Technetium; D015282:Octreotide