title: Comparison of the current and a new RTVue OCT software version for detection of ganglion cell complex changes due to cataract surgery.
abstract: The purpose was to compare the current (6.3) and a novel software version (6.12) of the RTVue-100 optical coherence tomograph (RTVue OCT) for ganglion cell complex (GCC) and retinal nerve fibre layer thickness (RNFLT) changes after phacoemulsification in healthy cataract eyes, and to investigate whether version 6.12, in which image segmentation is improved, provides benefits over version 6.3 for RNFLT and GCC imaging via mild cataract. One eye of 22 consecutive healthy cataract patients were imaged before and 1 month after uncomplicated cataract surgery using RTVue-100 OCT software version 6.3. The images were analysed with both software versions. Signal strength index increased significantly after surgery for both RNFLT and the GCC measurements (p ≤ 0.0015). No difference was seen for any RNFLT parameter between the software versions and time points (p ≥ 0.0140). The GCC values did not differ between the versions either before or after surgery (p ≥ 0.4471), but all increased significantly after surgery with software version 6.12 (p < 0.0001). Neither focal loss volume (FLV) nor global loss volume (GLV) differed between the software versions before and after surgery, respectively, but GLV decreased (improved) significantly after surgery (p = 0.010 and <0.001 for versions 6.3 and 6.12, respectively). Cataract surgery induced similar changes with both software versions, but version 6.12 identified the increase of GCC thickness and the decrease of GLV better than the current version. Although no significant difference between software versions was seen before surgery, our results suggest that version 6.12 may be more precise in measuring GCC parameters than the currently available version.
authors: Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary. hollo.gabor@med.semmelweis-univ.hu.
authors: Gábor
authors: G
authors: Holló
authors: Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.
authors: Farzaneh
authors: F
authors: Naghizadeh
authors: Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.|College of Medicine, University of Central Florida, Orlando, FL, USA.
authors: Sofia
authors: S
authors: Hsu
authors: Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.
authors: Tamás
authors: T
authors: Filkorn
authors: Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.
authors: Mária
authors: M
authors: Bausz
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D002387:Cataract Extraction / Q000379:methods; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009798:Ocular Hypertension / Q000175:diagnosis; D012165:Retinal Ganglion Cells / Q000473:pathology; D012984:Software; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000592:standards; D014792:Visual Acuity / Q000502:physiology
keywords: Cataract surgery; Ganglion cell complex; RTVue-100 Fourier-domain optical coherence tomography; Retinal nerve fibre layer thickness; Signal-to-noise ratio