title: Kinase-two-hybrid: towards the conditional interactome.
abstract: The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase-dependent yeast two‐hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyrosine phosphorylation regulates the changes in the interactome under varying conditions.
authors: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
authors: David
authors: D
authors: Ochoa
authors: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.
authors: Pedro
authors: P
authors: Beltrao
mesh_terms: D006801:Humans; D010750:Phosphoproteins / Q000378:metabolism*; D060066:Protein Interaction Maps; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D010750:Phosphoproteins; D014443:Tyrosine