title: Richter syndrome: an aggressive transformation.
abstract: A 71-year-old male patient named M.R. was diagnosed with chronic lymphocytic leukemia (CLL). At the time of diagnosis, M.R. had generalized lymphadenopathy and splenomegaly, which caused him to experience significant abdominal discomfort. M.R. was treated with six cycles of fludarabine, cyclophosphamide, and rituximab (FCR), which is standard first-line chemotherapy, and tolerated this fairly well. His lymphadenopathy quickly resolved and, aside from mild nausea, had no complications from treatment.  .
authors: CancerCare Manitoba, Winnipeg, Canada.
authors: Erin
authors: E
authors: Streu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D002999:Clone Cells / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D064946:Hospice and Palliative Care Nursing; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood / Q000175:diagnosis / Q000451:nursing / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D010166:Palliative Care / Q000523:psychology; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D012307:Risk Factors; D000069283:Rituximab / Q000008:administration & dosage; D016879:Salvage Therapy; D013577:Syndrome; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014408:Biomarkers, Tumor; D009944:Organoplatinum Compounds; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D007770:L-Lactate Dehydrogenase; D014740:Vidarabine; C024352:fludarabine; D011241:Prednisone
keywords: Patient education; Richter syndrome; chronic lymphocytic leukemia; dual diagnosis