title: [Elective single embryo transfer policy at 48/72 h: which results after fresh transfers and frozen/thawed transfers?].
abstract: OBJECTIVE
  To evaluate our elective single embryo transfer policy performed at 48/72h and define predictive factors of pregnancy after frozen/thawed embryo transfer.
  
  
  METHODS
  Analysis of 289 elective single embryo transfers (eSET) performed in a selected population in the ART center of Marseille University Hospital from January 2005 to December 2011, as well as the 325 following frozen/thawed embryo transfers performed in this population between May 2005 and December 2012.
  
  
  RESULTS
  Cumulative pregnancy rate/oocyte retrieval was of 62.6%; 45% of the couples obtained the birth of at least one child. During this studied period, cumulative pregnancy and delivery rates in the whole population remained stable while multiple delivery rate/delivery clearly decreased. Elective single embryo after frozen/thawed transfer gave satisfying results (24.6% pregnancy/transfer) only in the lack of lysis or in case of mild lysis (1-25%) of the transferred embryo.
  
  
  CONCLUSIONS
  The implementation of an eSET policy gives satisfying results, depending largely on embryo quality. By proposing eSET to a well-targeted population, chosen both on clinical and biological criteria, a clear reduction of cumulative multiple delivery rate/delivery was obtained in our center over this period, without any global decrease of cumulative pregnancy rate/attempt. Embryo quality is a major factor of success, especially in frozen/thawed cycles. The elective single embryo frozen/thawed transfer should be carried out only if embryo lysis after thawing does not exceed 25%.
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France.
authors: P
authors: P
authors: Bottin
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France; Laboratoire d'histologie-embryologie, faculté de médecine de Marseille, Aix-Marseille université, 27, boulevard Jean-Moulin, 13005 Marseille, France; Équipe biogénotoxicologie, santé humaine et environnement, institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), UMR 7263 - IRD 237/FR CNRS 3098, Aix-Marseille université, 13005 Marseille, France. Electronic address: vincent.achard@ap-hm.fr.
authors: V
authors: V
authors: Achard
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France; Équipe biogénotoxicologie, santé humaine et environnement, institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), UMR 7263 - IRD 237/FR CNRS 3098, Aix-Marseille université, 13005 Marseille, France.
authors: B
authors: B
authors: Courbiere
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France.
authors: M
authors: M
authors: Paci
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France.
authors: A
authors: A
authors: Gnisci
authors: CIC-CPCET, centre d'évaluation thérapeutique et de biostatistiques, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France.
authors: E
authors: E
authors: Jouve
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France; Laboratoire d'histologie-embryologie, faculté de médecine de Marseille, Aix-Marseille université, 27, boulevard Jean-Moulin, 13005 Marseille, France.
authors: J-M
authors: JM
authors: Grillo
authors: Centre clinico-biologique d'assistance médicale à la procréation, Gynépôle, CHU de la Conception, AP-HM, 147, boulevard Baille, 13005 Marseille, France; Laboratoire d'histologie-embryologie, faculté de médecine de Marseille, Aix-Marseille université, 27, boulevard Jean-Moulin, 13005 Marseille, France.
authors: O
authors: O
authors: Paulmyer-Lacroix
mesh_terms: D015925:Cryopreservation; D017558:Elective Surgical Procedures; D004624:Embryo Transfer / Q000379:methods; D005260:Female; D005602:France; D006358:Hot Temperature; D006801:Humans; D057766:Policy; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple; D056826:Single Embryo Transfer / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Accouchement multiple; Cumulative pregnancy rate; Elective transfer; Embryo lysis; Embryo quality; FIV; Frozen/thawed embryo transfer; Lyse embryonnaire; Multiple delivery; Qualité embryonnaire; Taux cumulés de grossesse; Transfert d’embryons congelés; Transfert électif