title: Increased risk of dementia among patients with pulmonary tuberculosis: a retrospective population-based cohort study.
abstract: OBJECTIVE
  We investigated and compared the risk of dementia development in a cohort of patients with tuberculosis (TB).
  
  
  METHODS
  The study involved 6473 patient with newly diagnosed TB, and each patient was randomly frequency matched with 4 people without TB based on age, sex, and index year. The risk of dementia development was analyzed using Cox proportional hazards regression.
  
  
  RESULTS
  Among the patients with TB, the overall risk of developing dementia was 1.21-fold significantly higher than the non-TB cohort. In the stratified analysis of dementia risks, only the patients with TB who were male or 50 to 64 years of age exhibited a significantly higher risk of dementia development compared with those without TB. An analysis of the follow-up duration revealed that patients with TB had a 1.78-fold increased risk within 1 year of follow-up.
  
  
  CONCLUSIONS
  Patients with TB have a significantly higher risk of developing dementia than that of the general population.
authors: Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan Department of Respiratory Therapy, China Medical University, Taichung, Taiwan.
authors: Yi-Hao
authors: YH
authors: Peng
authors: Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: Chih-Yu
authors: CY
authors: Chen
authors: Section of Respiratory Therapy, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.
authors: Ching-Hua
authors: CH
authors: Su
authors: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan.
authors: Chih-Hsin
authors: CH
authors: Muo
authors: Department of Neurology, China Medical University Hospital, Taichung, Taiwan Department of Neurology, China Medical University Beigang Hospital, Yunlin, Taiwan.
authors: Kuan-Fei
authors: KF
authors: Chen
authors: Department of Respiratory Therapy, China Medical University, Taichung, Taiwan Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: Wei-Chih
authors: WC
authors: Liao
authors: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan d10040@mail.cmuh.org.tw.
authors: Chia-Hung
authors: CH
authors: Kao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D016208:Databases, Factual / Q000706:statistics & numerical data; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012306:Risk; D013624:Taiwan / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*; D055815:Young Adult
keywords: cohort study; comorbidity; dementia; tuberculosis