title: Systems Toxicology: The Future of Risk Assessment.
abstract: Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment. Developing such an approach requires a mechanistic understanding of the process by which xenobiotic substances perturb biological systems and lead to toxicity. Supplementing the shortfalls of traditional risk assessment with mechanistic biological data has been widely discussed but not routinely implemented in the evaluation of chemical exposure. These mechanistic approaches to risk assessment have been generally referred to as systems toxicology. This Symposium Overview article summarizes 4 talks presented at the 35th Annual Meeting of the American College of Toxicology.
authors: Predictive Safety Testing Consortium (PSTC), Critical Path Institute, Tucson, AZ, USA.
authors: John Michael
authors: JM
authors: Sauer
authors: Bloomberg School of Public Health, John Hopkins University, Baltimore, MD, USA.
authors: Thomas
authors: T
authors: Hartung
authors: University of Konstanz, Konstanz, Germany.
authors: Marcel
authors: M
authors: Leist
authors: US Environmental Protection Agency, Research Triangle Park, NC, USA.
authors: Thomas B
authors: TB
authors: Knudsen
authors: Philip Morris International R&D, Neuchâtel, Switzerland.
authors: Julia
authors: J
authors: Hoeng
authors: Harvard University, Cambridge, MA, USA University of Massachusetts School of Public Health, Amherst, MA, USA awallacehayes@comcast.net.
authors: A Wallace
authors: AW
authors: Hayes
mesh_terms: D000818:Animals; D003226:Congresses as Topic; D004195:Disease Models, Animal; D004781:Environmental Exposure; D015386:Hazardous Substances / Q000633:toxicity; D006801:Humans; D018570:Risk Assessment; D014116:Toxicology; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D015386:Hazardous Substances; D015262:Xenobiotics
keywords: risk assessment; systems toxicology