title: Modularity enhances the rate of evolution in a rugged fitness landscape.
abstract: Biological systems are modular, and this modularity affects the evolution of biological systems over time and in different environments. We here develop a theory for the dynamics of evolution in a rugged, modular fitness landscape. We show analytically how horizontal gene transfer couples to the modularity in the system and leads to more rapid rates of evolution at short times. The model, in general, analytically demonstrates a selective pressure for the prevalence of modularity in biology. We use this model to show how the evolution of the influenza virus is affected by the modularity of the proteins that are recognized by the human immune system. Approximately 25% of the observed rate of fitness increase of the virus could be ascribed to a modular viral landscape.
authors: Department of Physics & Astronomy Rice University, Houston, TX 77005-1892, USA. Department of Physics, The Catholic University of Korea, Bucheon 420-743, Korea.
authors: Jeong-Man
authors: JM
authors: Park
authors: Man
authors: M
authors: Chen
authors: Dong
authors: D
authors: Wang
authors: Michael W
authors: MW
authors: Deem
mesh_terms: D005075:Biological Evolution; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D056084:Genetic Fitness; D006801:Humans; D007113:Immunity, Innate; D009980:Influenza A virus / Q000235:genetics / Q000502:physiology; D007251:Influenza, Human; D008957:Models, Genetic; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014764:Viral Proteins