title: Influence of asafoetida on prevention and treatment of memory impairment induced by d-galactose and NaNO2 in mice.
abstract: In Iranian traditional medicine, asafoetida is introduced as a valuable remedy for nervous disorders. Dementia was induced by injection of d-galactose and NaNO2 for 60 consecutive days. Animals were divided into normal control (NC), dementia control (DC), dementia prophylactic (DP), and dementia treated (DT). The learning and memory functions were examined by 1-way active and passive avoidance tests, using a shuttle box device. Avoidance response in training tests and 1 and 3 weeks later was significantly increased in NC, DP, and DT groups compared to the DC group. Step through latency in all groups was significantly greater than the DC group. Total time spent in light room, which shows the memory retention ability, in DP, NC, and DT was significantly greater than the DC group. Our findings indicate that asafoetida could prevent and treat amnesia. These beneficial effects maybe related to some constituent's effectiveness such as ferulic acid and umbelliferone.
authors: Department of Physiology, Herbal Medicine Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, Islamic Republic of Iran.
authors: Seyyed Majid
authors: SM
authors: Bagheri
authors: Department of Physiology, Herbal Medicine Research Center, Shahid Sadoghi University of Medical Sciences, Yazd, Islamic Republic of Iran dashti_mh@yahoo.com.
authors: Mohammad Hossein
authors: MH
authors: Dashti-R
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003704:Dementia / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D004195:Disease Models, Animal; D005309:Ferula; D005520:Food Preservatives / Q000008:administration & dosage / Q000494:pharmacology; D005690:Galactose / Q000008:administration & dosage / Q000494:pharmacology; D007492:Iran; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D051379:Mice; D008517:Phytotherapy / Q000379:methods*; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D012977:Sodium Nitrite / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D005520:Food Preservatives; D028321:Plant Preparations; D012977:Sodium Nitrite; D005690:Galactose
keywords: Alzheimer’s disease; NaNO2; asafoetida; d-galactose; shuttle box