title: A novel safety assessment strategy applied to non-selective extracts.
abstract: A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult to determine. Here, a pragmatic novel safety assessment strategy is applied to the production of non-selective extracts (NSEs), used for different purposes in food such as for colouring purposes, which are complex food mixtures prepared from reference juices. The Complex Mixture Safety Assessment Strategy (CoMSAS) is an exposure driven approach enabling to efficiently assess the safety of the NSE by focussing on newly formed substances or substances that may increase in exposure during the processing of the NSE. CoMSAS enables to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure. This will reduce the amount of work needed for identification, characterisation and safety assessment of unknown substances detected at low concentration, without the need for toxicity testing using animal studies. In this paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes.
authors: TNO, Zeist, The Netherlands.
authors: Sander
authors: S
authors: Koster
authors: TNO, Zeist, The Netherlands. Electronic address: winfried.leeman@tno.nl.
authors: Winfried
authors: W
authors: Leeman
authors: TNO, Zeist, The Netherlands.
authors: Elwin
authors: E
authors: Verheij
authors: TNO, Zeist, The Netherlands.
authors: Ellen
authors: E
authors: Dutman
authors: TNO Triskelion, Zeist, The Netherlands.
authors: Leo
authors: L
authors: van Stee
authors: Chr. Hansen, Hørsholm, Denmark.
authors: Lene Munch
authors: LM
authors: Nielsen
authors: Coca-Cola Services, Brussels, Belgium.
authors: Stefan
authors: S
authors: Ronsmans
authors: The Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, The Netherlands.
authors: Hub
authors: H
authors: Noteborn
authors: TNO, Zeist, The Netherlands.
authors: Lisette
authors: L
authors: Krul
mesh_terms: D045424:Complex Mixtures / Q000737:chemistry* / Q000633:toxicity; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis / Q000517:prevention & control; D005511:Food Handling; D059022:Food Safety / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D064088:Hazard Analysis and Critical Control Points; D006801:Humans
chemical_list: D045424:Complex Mixtures
keywords: Complex mixture safety assessment strategy; Non-selective extract; Processing; Safety; TTC; Threshold of toxicological concern