title: Relationship between postprandial endotoxemia in nonobese postmenopausal women and diabetic nonobese postmenopausal women.
abstract: BACKGROUND
  We hypothesised that nonobese postmenopausal women (NoPoW) and diabetic NoPoW (DNoPoW) may be independently associated with postprandial endotoxemia.
  
  
  METHODS
  NoPoW and DNoPoW were evaluated for weight, eating habits, physical activity, body circumferences, fasting plasma glucose level, postprandial plasma glucose level, and insulin level. The lipopolysaccharide (LPS) levels and circulating LPS-binding protein (LBP) were determined in serum at fasting, 1 h, 2 h, 3 h, and 4 h after meal intake and their levels were co-related in 80 NoPoW and 80 DNoPoW.
  
  
  RESULTS
  Both DNoPoW group and NoPoW group showed a significant increase (P < 0.05) in LPS levels and circulating LBP in plasma after the meal intake, interestingly the increase was higher in the DNoPoW group.
  
  
  CONCLUSIONS
  Elevated LPS and circulating LBP were associated significantly with DNoPoW group and NoPoW, especially after a meal intake. These findings suggested a role of LPS and LBP in postprandial systemic inflammation in DNoPoW group. Prospective studies are needed to confirm these results.
authors: Department of Clinical Biochemistry, Government College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.
authors: Gaffar Sarwar
authors: GS
authors: Zaman
authors: Head of Operations and Quality Manager Ekopath Metropolis, Guwahati, Assam, India.
authors: Fawzia
authors: F
authors: Zaman
keywords: Endotoxemia; lipopolysaccharide; lipopolysaccharide-binding protein; postmenopause