title: [A clinical study on high-dose erythropoietin therapy for acute encephalopathy or encephalitis].
abstract: OBJECTIVE
  We performed high-dose erythropoietin therapy (hEPO) for acute encephalopathy or encephalitis (AE), and evaluated its safety and efficacy.
  
  
  METHODS
  We performed hEPO in AE patients with widespread lesions demonstrated by diffusion-weighted imaging, and prospectively investigated changes in hemoglobin levels, adverse events, changes in images, and developmental quotients.
  
  
  RESULTS
  All four patients showed neither an increase in the hemoglobin level nor adverse event possibly related to hEPO. One patient with acute encephalitis showed resolution of the lesion and normal developmental quotient. Two patients who had acute encephalopathy with febrile convulsive status epilepticus showed mild cerebral atrophy in the recovery phase;one had a normal developmental quotient. The patient with acute necrotizing encephalopathy including a brainstem lesion avoided acute-phase death.
  
  
  CONCLUSIONS
  Two patients showed no sequelae despite images indicating widespread abnormality. hEPO could be performed safely in patients with AE, however further trials are necessary concerning its efficacy.
authors: Ichiro
authors: I
authors: Kuki
authors: Hisashi
authors: H
authors: Kawawaki
authors: Asako
authors: A
authors: Horino
authors: Takeshi
authors: T
authors: Inoue
authors: Meguni
authors: M
authors: Nukui
authors: Shin
authors: S
authors: Okazaki
authors: Kiyotaka
authors: K
authors: Tomiwa
authors: Kiyoko
authors: K
authors: Amo
authors: Masao
authors: M
authors: Togawa
authors: Masashi
authors: M
authors: Shiomi
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D004660:Encephalitis / Q000188:drug therapy* / Q000503:physiopathology; D004921:Erythropoietin / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome
chemical_list: D004921:Erythropoietin