title: The value of a panel of autoantibodies for predicting the activity of lupus nephritis at time of renal biopsy.
abstract: Few studies have correlated serum biomarkers with renal histology, the gold standard for renal activity, in lupus nephritis (LN). We tested a panel of autoantibodies and complement at the time of kidney biopsy and after treatment. Anti-dsDNA, anti-nucleosome, anti-ribosome P, and anti-C1q antibodies and C3/C4 were measured in 107 patients with LN at the time of renal biopsy and after 6-12 months and were correlated with clinical/histological parameters. At multivariate analysis, high titers of anti-C1q antibodies or of anti-dsDNA antibodies (P = 0.005, OR = 8.67, CI: 2.03-37.3) were the independent predictors that discriminate proliferative from nonproliferative LN. All the immunological parameters, except anti-ribosome, showed a significant correlation with activity index but not with chronicity index. Only anti-C1q showed a significant correlation with the amount of proteinuria (R = 0.2, P = 0.03). None of the immunological parameters were predictive of remission at 6 and 12 months. We found that anti-C1q alone or in combination with anti-dsDNA emerged as the most reliable test in differentiating proliferative and nonproliferative LN. Anti-C1q was the only test correlated with the clinical presentation of LN. After treatment, the titre of the autoantibodies was significantly reduced, but none was predictive of remission.
authors: Division of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, Italy.
authors: Gabriella
authors: G
authors: Moroni
authors: Department of Informatics, Università degli Studi di Pavia, 27100 Pavia, Italy.
authors: Silvana
authors: S
authors: Quaglini
authors: Institute of Microbiology, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy ; Renal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy.
authors: Antonella
authors: A
authors: Radice
authors: Renal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy.
authors: Barbara
authors: B
authors: Trezzi
authors: Division of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, Italy.
authors: Francesca
authors: F
authors: Raffiotta
authors: Division of Nephrology, Fondazione Ospedale Maggiore, Mangiagalli, Regina Elena, 20122 Milano, Italy.
authors: Piergiorgio
authors: P
authors: Messa
authors: Renal Unit and Clinical Immunology Unit, Azienda Ospedaliera, Ospedale San Carlo Borromeo, 20153 Milano, Italy.
authors: Renato Alberto
authors: RA
authors: Sinico
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D015415:Biomarkers; D001706:Biopsy; D005260:Female; D006801:Humans; D007668:Kidney / Q000276:immunology* / Q000473:pathology*; D008181:Lupus Nephritis / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers