title: Two half-sandwiched ruthenium (II) compounds containing 5-fluorouracil derivatives: synthesis and study of DNA intercalation.
abstract: Two novel coordination compounds of half-sandwiched ruthenium(II) containing 2-(5-fluorouracil)-yl-N-(pyridyl)-acetamide were synthesized, and their intercalation binding modes with calf thymus DNA were revealed by hyperchromism of ultraviolet-visible spectroscopy; the binding constants were determined according to a Langmuir adsorption equation that was deduced on the base of careful cyclic voltammetry measurements. The two compounds exhibited DNA intercalation binding activities with the binding constants of 1.13×106 M-1 and 5.35 ×105 M-1, respectively.
authors: Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Key Laboratory of Plant Nutrition and Fertilizer, Ministry of Agriculture, Beijing, China.
authors: Zhao-Jun
authors: ZJ
authors: Li
authors: Institute of Biotechnology and Nucleic Technology, Sichuan Academy of Agricultural Sciences, Chengdu, China.
authors: Yong
authors: Y
authors: Hou
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China.
authors: Da-An
authors: DA
authors: Qin
authors: College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
authors: Zhi-Min
authors: ZM
authors: Jin
authors: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, China.
authors: Mao-Lin
authors: ML
authors: Hu
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D055664:Electrochemical Techniques; D004566:Electrodes; D005472:Fluorouracil / Q000737:chemistry*; D007364:Intercalating Agents / Q000138:chemical synthesis* / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D056831:Coordination Complexes; D007364:Intercalating Agents; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA; D005472:Fluorouracil