title: Oxidized LDL and NO synthesis--Biomarkers of endothelial dysfunction and ageing.
abstract: Oxidized LDL (oxLDL) and nitric oxide (NO) exert contradictory actions within the vascular endothelium microenvironment influencing key events in atherogenesis. OxLDL and NO are so far regarded as representative parameters of oxidative stress and endothelial dysfunction, new targets in prevention, diagnosis and therapy of cardiovascular diseases, and also as candidate biomarkers in evaluating the human biological age. The aim of this review is to explore recent literature on molecular mechanisms and pathophysiological relationships between LDL oxidation, NO synthesis and vascular endothelium function/dysfunction in ageing, focusing on the following aspects: (1) the impact of metabolic status on both LDL oxidation and NO synthesis in relation with oxidative stress, (2) the use of oxidized LDL and NO activity as biomarkers in human studies reporting on cardiovascular outcomes, and (3) evidences supporting the importance of oxidized LDL and NO activity as relevant biomarkers in vascular ageing and age-related diseases.
authors: Ana Aslan National Institute of Gerontology and Geriatrics, 9 Caldarusani Street, Sector 1, P.O. Box 2-4, 011241 Bucharest, Romania; Carol Davila University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Biochemistry, 6 Taian Vuia Street, Sector 2, 020956 Bucharest, Romania. Electronic address: daniela.gradinaru@umf.ro.
authors: Daniela
authors: D
authors: Gradinaru
authors: Ana Aslan National Institute of Gerontology and Geriatrics, 9 Caldarusani Street, Sector 1, P.O. Box 2-4, 011241 Bucharest, Romania.
authors: Claudia
authors: C
authors: Borsa
authors: Ana Aslan National Institute of Gerontology and Geriatrics, 9 Caldarusani Street, Sector 1, P.O. Box 2-4, 011241 Bucharest, Romania.
authors: Cristina
authors: C
authors: Ionescu
authors: Ana Aslan National Institute of Gerontology and Geriatrics, 9 Caldarusani Street, Sector 1, P.O. Box 2-4, 011241 Bucharest, Romania; Carol Davila University of Medicine and Pharmacy, Faculty of Medicine, Department of Geriatrics and Gerontology, 37 Dionisie Lupu Street, Sector 2, 020021 Bucharest, Romania.
authors: Gabriel Ioan
authors: GI
authors: Prada
mesh_terms: D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D009569:Nitric Oxide
keywords: Ageing; Biomarker; Endothelial dysfunction; Nitric oxide; Oxidized LDL