title: "...Rewritten in the skin": clues to skin biology and aging from inherited disease.
abstract: The growing diversity of heritable skin diseases, a practical challenge to clinicians and dermato-nosologists alike, has nonetheless served as a rich source of insight into skin biology and disease mechanisms. I summarize below some key insights from the recent gene-driven phase of research on Werner syndrome, a heritable adult progeroid syndrome with prominent dermatologic features, constitutional genomic instability, and an elevated risk of cancer. I also indicate how new insights into skin biology, disease, and aging may come from unexpected sources.
authors: Department of Pathology and Genome Sciences, University of Washington, Seattle, Washington, USA. Electronic address: monnat@u.washington.edu.
authors: Raymond J
authors: RJ
authors: Monnat
mesh_terms: D000375:Aging; D000818:Animals; D001816:Bloom Syndrome / Q000235:genetics; D003880:Dermatology / Q000379:methods; D018450:Disease Progression; D005192:Family Health; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D016678:Genome; D042822:Genomic Instability; D006801:Humans; D051379:Mice; D010641:Phenotype; D053484:RecQ Helicases / Q000378:metabolism; D012307:Risk Factors; D012879:Skin Physiological Phenomena; D013577:Syndrome; D014898:Werner Syndrome / Q000235:genetics*
chemical_list: D053484:RecQ Helicases