title: Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study.
abstract: Pretransplant influenza vaccination of the donor or allogeneic hematopoietic SCT (HSCT) candidate was evaluated in a randomized study. One hundred and twenty-two HSCT recipients and their donors were assigned to three randomization groups: no pretransplant vaccination (n=38), donor pretransplant vaccination (n=44) or recipient pretransplant vaccination (n=40). Specific IgG was assessed by both hemagglutinin inhibition (HI) and, in 57 patients, by an indirect influenza-specific ELISA at specified times after HSCT. Vaccinated donors had seroprotective HI titers for Ags H1 and H3 (P<0.001) compared with the other groups at the time of donation. The titers against H1 (P=0.028) and H3 (P<0.001) were highest in the pretransplant recipient vaccination group until day 180 after transplantation. A significant difference was found in the specific Ig levels against pandemic H1N1 at 6 months after SCT (P=0.02). The mean IgG levels against pandemic H1N1 and generic H1N1 and H3N2 were highest in the pretransplant recipient vaccination group. We conclude that pretransplant recipient vaccination improved the influenza-specific seroprotection rates.
authors: 1] Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden [2] Centre for Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden.
authors: A
authors: 0000000184623552
authors: A
authors: Ambati
authors: Virology Laboratory (LIM 52-HCFMUSP), Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.
authors: L S V
authors: LS
authors: Boas
authors: 1] Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden [2] Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
authors: P
authors: 0000000282813245
authors: P
authors: Ljungman
authors: Hematopoietic Stem Cell Transplant Program, Amaral Carvalho Foundation, Jahu, Brazil.
authors: L
authors: L
authors: Testa
authors: Clinics Hospital - School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors: J F
authors: JF
authors: de Oliveira
authors: Division of Therapeutic Immunology (TIM), Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
authors: M
authors: M
authors: Aoun
authors: Hematopoietic Stem Cell Transplant Program, Amaral Carvalho Foundation, Jahu, Brazil.
authors: V
authors: V
authors: Colturato
authors: 1] Centre for Allogeneic Stem Cell Transplantation (CAST), Karolinska University Hospital, Stockholm, Sweden [2] Division of Therapeutic Immunology (TIM), Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
authors: M
authors: M
authors: Maeurer
authors: 1] Virology Laboratory (LIM 52-HCFMUSP), Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil [2] Hematopoietic Stem Cell Transplant Program, Amaral Carvalho Foundation, Jahu, Brazil.
authors: C M
authors: CM
authors: Machado
mesh_terms: D000328:Adult; D064591:Allografts; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D011300:Preoperative Care; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007252:Influenza Vaccines