title: Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family.
abstract: Alleles at the D7S820 STR locus have 6-14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10-11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10-11 were a linked inheritance in this family.
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Erlie
authors: E
authors: Jiang
authors: DNA Typing Laboratory, Shanghai Tissuebank Biotechnology Co., LTD, Shanghai, China.
authors: Jie
authors: J
authors: Pan
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Mingzhe
authors: M
authors: Han
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Liang
authors: L
authors: Chen
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Qiaoling
authors: Q
authors: Ma
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Jialin
authors: J
authors: Wei
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Yong
authors: Y
authors: Huang
authors: Department of Hematology, Tianjin Hematonosis Hospital, Tianjin, China.
authors: Sizhou
authors: S
authors: Feng
authors: DNA Typing Laboratory, Shanghai Tissuebank Biotechnology Co., LTD, Shanghai, China.
authors: Qin
authors: Q
authors: Sun
authors: DNA Typing Laboratory, Shanghai Tissuebank Biotechnology Co., LTD, Shanghai, China.
authors: Peili
authors: P
authors: Xiao
authors: DNA Typing Laboratory, Shanghai Tissuebank Biotechnology Co., LTD, Shanghai, China. zhengzhongzheng@catb.net.cn.
authors: Zhongzheng
authors: Z
authors: Zheng
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D016172:DNA Fingerprinting; D005787:Gene Frequency; D008040:Genetic Linkage; D056426:Genetic Loci; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction
keywords: D7S820 locus; DNA typing; Short tandem repeat (STR); Tri-allelic patterns