title: Non-tumor-Associated Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in Chinese Girls With Positive Anti-thyroid Antibodies.
abstract: Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a new category of autoimmune encephalitis associated with anti-NMDA receptor antibodies. The disease was first described in 2007, and it predominantly affects young women with or without ovarian teratomas. Most patients typically present with seizures, a decreased consciousness level, dyskinesia, autonomic dysfunction, and psychiatric symptoms. The presence of anti-thyroid antibodies in non-tumor-associated anti-NMDA receptor encephalitis was first described in 2010. Additionally, anti-thyroid antibodies were found in teratoma-associated anti-NMDA receptor encephalitis. We report the cases of 3 Chinese girls with non-tumor-associated anti-NMDA receptor encephalitis with positive anti-thyroid antibodies. We followed up the details of their titers and suggest that anti-thyroid antibodies were an indicator of autoimmune predisposition in the development of non-tumor-associated anti-NMDA receptor encephalitis.
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Wenjuan
authors: W
authors: Guan
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Zhenqiang
authors: Z
authors: Fu
authors: Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, Henan, People's Republic of China.
authors: Hui
authors: H
authors: Zhang
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Lijun
authors: L
authors: Jing
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Jingjing
authors: J
authors: Lu
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Jing
authors: J
authors: Zhang
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Hong
authors: H
authors: Lu
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
authors: Junfang
authors: J
authors: Teng
authors: Department of Neurology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, People's Republic of China jiayanjie1971@aliyun.com.
authors: Yanjie
authors: Y
authors: Jia
mesh_terms: D000293:Adolescent; D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D001323:Autoantibodies
keywords: anti-N-methyl-d-aspartate (NMDA) receptor encephalitis; anti-thyroid antibodies; chinese adolescents