title: Association of chronic thromboembolic pulmonary hypertension with hereditary and acquired risk factors for thromboembolism.
abstract: Thrombophilia increases the incidence of pulmonary thrombosis significantly. Various hereditary and acquired factors are known for thromboembolism. The hereditary factors are two common genetic autosomal mutations including factor V leidan mutation and prothrombin gene mutation. A descriptive- analytical design was conducted on 60 patients with thromboembolism who met the inclusion criteria. Two groups with hereditary and acquired risk factors for thromboembolism (group A, B, each 30 people) were evaluated. All the patients of two groups were evaluated in terms of emboli associated with hereditary and acquired risk factors. Association of thromboembolism risk factors' with pulmonary hypertension were studied at the beginning of the study and six months after the treatment then the results of two groups were compared. Among participants, 31 (56.4%) were men.  The mean age of the patients was 44.4±14 years, ranging between 23-75 years. Significant association was observed between the stability of the blood clot in pulmonary vessel, six months after the treatment with genetic risk factors (P=0.03). However, no significant association was between pulmonary hypertension and hereditary and acquired risk factors (P=0.24). Based on the significant association between the hereditary risk factors and pulmonary emboli, by taking special prevention and therapy measurements (e.g. genetic engineering), some pulmonary and mortality complications can be prevented and the patient himself and health care system would benefit from this issue.
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ghaffary.mohammadreza@yahoo.com.
authors: Mohammad Reza
authors: MR
authors: Ghaffary
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Kansarin@yahoo.com.
authors: Khalil
authors: K
authors: Ansarin
authors: Department of Genetics, Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Esakhinia@yahoo.uk.com.
authors: Ebrahim
authors: E
authors: Sakhinia
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. akhorami@yahoo.com.
authors: Ali Reza
authors: AR
authors: Khoramifar
mesh_terms: D000328:Adult; D000368:Aged; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000473:pathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D013923:Thromboembolism / Q000209:etiology* / Q000235:genetics; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000209:etiology / Q000235:genetics / Q000473:pathology; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V