title: Safety of recombinant VSV-Ebola virus vaccine vector in pigs.
abstract: The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
authors: Emmie
authors: E
authors: de Wit
authors: Andrea
authors: A
authors: Marzi
authors: Trenton
authors: T
authors: Bushmaker
authors: Doug
authors: D
authors: Brining
authors: Dana
authors: D
authors: Scott
authors: Juergen A
authors: JA
authors: Richt
authors: Thomas W
authors: TW
authors: Geisbert
authors: Heinz
authors: H
authors: Feldmann
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D004274:DNA, Recombinant; D029043:Ebolavirus / Q000235:genetics*; D005822:Genetic Vectors / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics* / Q000276:immunology; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D013552:Swine; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000235:genetics* / Q000276:immunology; D014779:Virus Replication; D017201:Virus Shedding
chemical_list: D000914:Antibodies, Viral; D004274:DNA, Recombinant; D007074:Immunoglobulin G; D014765:Viral Vaccines
keywords: Ebola virus; VSV; VSV vaccine; pigs; recombinant VSV–Ebola virus vaccine vector; safety; vaccines; vesicular stomatitis viruses; viruses; zoonoses