title: Prognostic value of microRNA-145 in patients with various cancers: a meta-analysis.
abstract: BACKGROUND
  MicroRNA-145 (miR-145) plays a crucial role in cancer prognosis.
  
  
  OBJECTIVE
  This study aimed to investigate the prognostic value of miR-145 in patients with various cancers.
  
  
  METHODS
  We pooled published literature from PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews and calculated the hazard ratios (HRs) with 95% confidence intervals (CIs) to estimate the correlation between miR-145 expression levels and survival of patients with general cancers.
  
  
  RESULTS
  A total of 615 cases from 8 studies of multiple cancers were examined in this meta-analysis. The HR for overall survival (OS) of low miR-145 expression in multiple cancers was 1.80 (95% CI = 1.19-2.70). Furthermore, after excluding 1 study for its potential heterogeneity, the results suggested an increasing prognostic value of low miR-145 expression (HR = 2.20, 95% CI = 1.63-1.97). In addition, there was no significant difference between miR-145 expression levels and recurrence-free survival (RFS).
  
  
  CONCLUSIONS
  In conclusion, our findings suggest that miR-145 expression is associated with OS in cancer patients and can serve as a promising biomarker for monitoring prognosis.
authors: Shu-Long
authors: SL
authors: Dai
authors: Jin
authors: J
authors: Zhou
authors: Chao
authors: C
authors: Pan
authors: Guan
authors: G
authors: Huang
authors: Zuo-Liang
authors: ZL
authors: Shi
authors: Shi-Yong
authors: SY
authors: Yang
authors: Kun-Xing
authors: KX
authors: Yang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C541010:MIRN145 microRNA, human; D035683:MicroRNAs
keywords: cancer; meta-analysis; microRNA-145; prognosis