title: Fine control on the photochemical and photobiological properties of Ru(II) arene complexes.
abstract: A series of six Ru(arene) complexes, [(η(6)-p-cymene)Ru(dpb)(py-R)](2+) (1-6, dpb = 2,3-bis(2-pyridyl)benzoquinoxaline, py-R = 4-substituted pyridine, R = N(CH3)2, NH2, OCH3, H, COOCH3 and NO2), were synthesized and their photochemical and photobiological properties were compared in detail. The electron push/pull character of the R groups has a significant impact on both ligand photodissociation and (1)O2 generation of the complexes. The photoinduced DNA covalent binding capabilities increase from 1 to 6 under both aerobic and anaerobic conditions, and DNA photocleavage occurs simultaneously in aerobic environments. 4 has the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. The substituent effect may be ascribed to the influences of the R groups on the energy levels of (3)MC and (3)MLCT states as well as the energy gaps between (3)MC, (3)MLCT and dpb-based (3)IL states. Similar chemical modification on bidentate and arene ligands or other sites of the pyridine ligand may lead to more efficient agents with PDT and/or PACT activities.
authors: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. xswang@mail.ipc.ac.cn zhouqianxiong@mail.ipc.ac.cn.
authors: Yongjie
authors: Y
authors: Chen
authors: Wanhua
authors: W
authors: Lei
authors: Yuanjun
authors: Y
authors: Hou
authors: Chao
authors: C
authors: Li
authors: Guoyu
authors: G
authors: Jiang
authors: Baowen
authors: B
authors: Zhang
authors: Qianxiong
authors: Q
authors: Zhou
authors: Xuesong
authors: X
authors: Wang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D000081007:Cymenes; D004247:DNA / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D039821:Monoterpenes / Q000737:chemistry; D010782:Photolysis / Q000187:drug effects / Q000528:radiation effects; D011725:Pyridines / Q000737:chemistry; D011810:Quinoxalines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism
chemical_list: C482208:2,3-bis(2-pyridyl)benzoquinoxaline; D056831:Coordination Complexes; D000081007:Cymenes; D008024:Ligands; D039821:Monoterpenes; D011725:Pyridines; D011810:Quinoxalines; D013481:Superoxides; C007210:4-cymene; D012428:Ruthenium; D004247:DNA