title: Receptor usage and cell entry of porcine epidemic diarrhea coronavirus.
abstract: Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
authors: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
authors: Chang
authors: C
authors: Liu
authors: Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA.
authors: Jian
authors: J
authors: Tang
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: Yuanmei
authors: Y
authors: Ma
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: Xueya
authors: X
authors: Liang
authors: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
authors: Yang
authors: Y
authors: Yang
authors: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.
authors: Guiqing
authors: G
authors: Peng
authors: Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
authors: Qianqian
authors: Q
authors: Qi
authors: Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai, China.
authors: Shibo
authors: S
authors: Jiang
authors: Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
authors: Jianrong
authors: J
authors: Li
authors: Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, USA ldu@nybloodcenter.org lifang@umn.edu.
authors: Lanying
authors: L
authors: Du
authors: Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA ldu@nybloodcenter.org lifang@umn.edu.
authors: Fang
authors: F
authors: Li
mesh_terms: D000818:Animals; D018826:CD13 Antigens / Q000378:metabolism*; D002685:Chiroptera; D000882:Haplorhini; D006801:Humans; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D053485:Porcine epidemic diarrhea virus / Q000502:physiology*; D000085064:Receptors, Coronavirus; D011991:Receptors, Virus / Q000378:metabolism*; D013552:Swine; D053585:Virus Attachment; D053586:Virus Internalization
chemical_list: D000085064:Receptors, Coronavirus; D011991:Receptors, Virus; D018826:CD13 Antigens; D019158:N-Acetylneuraminic Acid