title: Selective C-arylation of 2,5-dibromo-3-hexylthiophene via Suzuki cross coupling reaction and their pharmacological aspects.
abstract: The present study reports the synthesis of various new derivatives based on 5-aryl-2-bromo-3-hexylthiophene with moderate-to-good yields via a palladium-catalyzed Suzuki cross-coupling reaction. This coupling method involved the reaction of 2,5-dibromo-3-hexylthiophene with several arylboronic acids in order to synthesize corresponding thiophene derivatives under controlled and optimal reaction conditions. The different substituents (CH3, OCH3, Cl, F etc.) present on arylboronic acids are found to have significant electronic effects on the overall properties of new products. The synthesized thiophene molecules were studied for their haemolytic, biofilm inhibition and anti-thrombolytic activities, and almost all products showed potentially good properties. The compound 2-bromo-5-(3-chloro-4-fluorophenyl)-3-hexylthiophenein particular exhibited the highest values for haemolytic and bio-film inhibition activities among all newly synthesized derivatives. In addition, the compound 2-bromo-3-hexyl-5-(4-iodophenyl)thiophene also showed high anti-thrombolytic activity, suggesting the potential medicinal applications of these newly synthesized compounds.
authors: Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan. chemistue@gmail.com.
authors: Hafiz Mansoor
authors: HM
authors: Ikram
authors: Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan. nasirrasool@gcuf.edu.pk.
authors: Nasir
authors: N
authors: Rasool
authors: Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan. gulchemist35@gmail.com.
authors: Gulraiz
authors: G
authors: Ahmad
authors: Department of Chemistry, SBA School of Science & Engineering, Lahore University of Management Sciences, Sector U, DHA, Lahore Cantt. 54792, Pakistan. ghayoor.abbas@lums.edu.pk.
authors: Ghayoor Abbas
authors: GA
authors: Chotana
authors: International Center for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. musharraf1977@yahoo.com.
authors: Syed Ghulam
authors: SG
authors: Musharraf
authors: Department of Chemistry, Government College University Faisalabad, Faisalabad 38000, Pakistan. nr_308@hotmail.com.
authors: Muhammad
authors: M
authors: Zubair
authors: Sustainable Energy Technologies (SET) center, College of Engineering, PO-Box 800, King Saud University, Riyadh 11421, Saudi Arabia. urana@ksu.edu.sa.
authors: Usman Ali
authors: UA
authors: Rana
authors: The Patent Office, Karachi 74200, Pakistan. ahirzia@gmail.com.
authors: Muhammad
authors: M
authors: Zia-Ul-Haq
authors: Department of Crop Science, Faculty of Agriculture, University Putra Malaysia, Serdang 43400, Selangor, Malaysia. hawazej@gmail.com.
authors: Hawa Ze
authors: HZ
authors: Jaafar
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D001773:Blood Cells / Q000187:drug effects*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D053878:Hemolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D005343:Fibrinolytic Agents; D053878:Hemolytic Agents; D013876:Thiophenes; D010165:Palladium; D002244:Carbon