title: Dye-free near-infrared surface-enhanced Raman scattering nanoprobes for bioimaging and high-performance photothermal cancer therapy.
abstract: Near-infrared surface-enhanced Raman scattering (NIR SERS) imaging is now a promising molecular imaging technology due to its narrow spectral bandwidth, low background interference and deep imaging depth. In this work, we report a novel strategy for fabrication of NIR SERS nanoprobes without using any expensive and highly toxic organic dyes. Multifunctional conducting polymer (CP) materials, serving as both biocompatible surface coatings and NIR-active reporters, are directly fabricated on the surface of gold nanorods (GNRs) via facile oxidative polymerization. The dye-free NIR SERS nanoprobes (GNR-CPs) exhibit good structural stability, good biocompatibility and intriguing NIR SERS activity. GNR-CPs also show an extraordinary NIR photothermal transduction efficiency, indicating the potential for cancer therapy. The applications of GNR-CPs as new types of theranostic agents for NIR SERS imaging and high-performance photothermal therapy are accomplished in vitro and in vivo.
authors: MOE Key Laboratory of Laser Life Science & SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou, Guangdong 510631, PR China. liuzm021@126.com ann@scnu.edu.cn.
authors: Zhiming
authors: Z
authors: Liu
authors: Binggang
authors: B
authors: Ye
authors: Mei
authors: M
authors: Jin
authors: Haolin
authors: H
authors: Chen
authors: Huiqing
authors: H
authors: Zhong
authors: Xinpeng
authors: X
authors: Wang
authors: Zhouyi
authors: Z
authors: Guo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D004396:Coloring Agents / Q000737:chemistry; D005260:Female; D006801:Humans; D051379:Mice; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D010777:Photochemistry; D011108:Polymers / Q000737:chemistry; D019265:Spectroscopy, Near-Infrared; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D004396:Coloring Agents; D011108:Polymers