title: Pregnancy-associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome.
abstract: OBJECTIVE
  To evaluate pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), procalcitonin, and troponin I levels as diagnostic markers of acute coronary syndrome in patients admitted to the emergency department.
  
  
  METHODS
  The serum PAPP-A, IMA, procalcitonin, and troponin I levels were measured in 100 patients with acute coronary syndrome admitted to the emergency department and 100 healthy control subjects.
  
  
  RESULTS
  Patients with acute coronary syndrome had significantly greater mean serum PAPP-A (patients, 10 ± 10 mIU/L; control subjects, 6 ± 10 mIU/L; P < 0.001), procalcitonin (patients, 2 ± 10 µg/L; control subjects, 0.4 ± 2 µg/L; P < 0.001), and troponin I levels (patients, 6 ± 8 µg/L; control subjects, 0.2 ± 0.3 µg/L; P < 0.001) than control subjects. There was no difference in mean IMA levels between patients and control subjects. There were no significant correlations between PAPP-A levels and IMA, procalcitonin, or troponin I levels in patients with acute coronary syndrome.
  
  
  CONCLUSIONS
  The PAPP-A, procalcitonin, and troponin I levels were increased in patients with acute coronary syndrome. Therefore, elevated PAPP-A and procalcitonin levels, in addition to troponin I levels, may be useful markers of myocardial injury on admission to the emergency department.
authors: Ayşegül
authors: A
authors: Bayir
authors: Hasan
authors: H
authors: Kara
authors: Aysel
authors: A
authors: Kiyici
authors: Bahadır
authors: B
authors: Özturk
authors: Abdullah
authors: A
authors: Sivrikaya
authors: Fikret
authors: F
authors: Akyürek
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011498:Protein Precursors / Q000097:blood*; D012307:Risk Factors; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D019210:Troponin I / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D012709:Serum Albumin; D019210:Troponin I; C561522:ischemia-modified albumin; D002116:Calcitonin; D011266:Pregnancy-Associated Plasma Protein-A; D015740:Calcitonin Gene-Related Peptide; D000075462:Serum Albumin, Human