title: Economic burden of common variable immunodeficiency: annual cost of disease.
abstract: OBJECTIVE
  In the context of the unknown economic burden imposed by primary immunodeficiency diseases, in this study, we sought to calculate the costs associated with the most prevalent symptomatic disease, common variable immunodeficiency (CVID).
  
  
  METHODS
  Direct, indirect and intangible costs were recorded for diagnosed CVID patients. Hidden Markov model was used to evaluate different disease-related factors and Monte Carlo method for estimation of uncertainty intervals.
  
  
  RESULTS
  The total estimated cost of diagnosed CVID is US$274,200/patient annually and early diagnosis of the disease can save US$6500. Hospital admission cost (US$25,000/patient) accounts for the most important expenditure parameter before diagnosis, but medication cost (US$40,600/patients) was the main factor after diagnosis primarily due to monthly administration of immunoglobulin.
  
  
  CONCLUSIONS
  The greatest cost-determining factor in our study was the cost of treatment, spent mostly on immunoglobulin replacement therapy of the patients. It was also observed that CVID patients' costs are reduced after diagnosis due to appropriate management.
authors: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Bamdad
authors: B
authors: Sadeghi
authors: Hassan
authors: H
authors: Abolhassani
authors: Ali
authors: A
authors: Naseri
authors: Nima
authors: N
authors: Rezaei
authors: Asghar
authors: A
authors: Aghamohammadi
mesh_terms: D017074:Common Variable Immunodeficiency / Q000175:diagnosis / Q000191:economics* / Q000628:therapy; D017046:Cost Savings; D017281:Cost of Illness; D042241:Early Diagnosis; D017048:Health Care Costs; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000191:economics* / Q000627:therapeutic use; D007492:Iran; D008390:Markov Chains; D017059:Models, Econometric; D009010:Monte Carlo Method; D012042:Registries
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: common variable immunodeficiency; cost; economic burden; primary immunodeficiency