title: Controlling the unfolded protein response-mediated life and death decisions in cancer.
abstract: Cancer cells are exposed to intrinsic (oncogene) or extrinsic (microenvironmental) challenges, leading to activation of stress response pathways. The unfolded protein response (UPR) is the cellular response to endoplasmic reticulum (ER) stress and plays a pivotal role in tumor development. Depending on ER stress intensity and duration, the UPR is either pro-survival to preserve ER homeostasis or pro-death if the stress cannot be resolved. On one hand, the adaptive arm of the UPR is essential for cancer cells to survive the harsh conditions they are facing, and on the other hand, cancer cells have evolved mechanisms to bypass ER stress-induced cell death, thereby conferring them with a selective advantage for malignant transformation. Therefore, the mechanisms involved in the balance between survival and death outcomes of the UPR may be exploited as therapeutic tools to treat cancer.
authors: Apoptosis Research Centre, National University of Ireland, Galway, Ireland; Centre de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France.
authors: Marion
authors: M
authors: Maurel
authors: Apoptosis Research Centre, National University of Ireland, Galway, Ireland.
authors: Eoghan P
authors: EP
authors: McGrath
authors: Apoptosis Research Centre, National University of Ireland, Galway, Ireland.
authors: Katarzyna
authors: K
authors: Mnich
authors: Apoptosis Research Centre, National University of Ireland, Galway, Ireland.
authors: Sandra
authors: S
authors: Healy
authors: Inserm U1052, F-33000, University of Bordeaux, Bordeaux, France; Centre de Lutte Contre le Cancer Eugène Marquis, 35000 Rennes, France.
authors: Eric
authors: E
authors: Chevet
authors: Apoptosis Research Centre, National University of Ireland, Galway, Ireland. Electronic address: afshin.samali@nuigalway.ie.
authors: Afshin
authors: A
authors: Samali
mesh_terms: D051702:Activating Transcription Factor 6 / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D017209:Apoptosis; D019070:Cell Lineage; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D004721:Endoplasmic Reticulum / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress; D004722:Endoribonucleases / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D056811:Unfolded Protein Response
chemical_list: C497111:ATF6 protein, human; D051702:Activating Transcription Factor 6; D000255:Adenosine Triphosphate; C528229:ERN1 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases
keywords: Apoptosis; Cancer; Cell death; ER stress; UPR