title: Antioxidant Houttuynia cordata extract upregulates filaggrin expression in an aryl hydrocarbon-dependent manner.
abstract: The plant Houttuynia cordata, which is called "dokudami" in Japanese, is known as a potent antioxidant herb that has been traditionally consumed as a folk medicine for various ailments, such as diabetes, obesity, cough, fever and skin diseases, in Asia. However, its antioxidant mechanism remains largely unknown. In the present study, we investigated the effects of Houttuynia cordata extract (HCE) on human keratinocytes. HCE activated aryl hydrocarbon receptor (AHR) and nuclear factor E2-related factor 2, with subsequent induction of the antioxidative enzyme NAD (P)H: quinone oxidoreductase 1 gene. HCE inhibited the generation of reactive oxygen species (ROS) in keratinocytes stimulated with tumor necrosis factor α or benzo(α)pyrene. Moreover, HCE upregulated the gene expression of filaggrin, an essential skin barrier protein, in an AHR-dependent manner. HCE may be beneficial for treating ROS-related photoaging and barrier-disrupted skin conditions.
authors: Kazuko
authors: K
authors: Doi
authors: Chikage
authors: C
authors: Mitoma
authors: Takeshi
authors: T
authors: Nakahara
authors: Hiroshi
authors: H
authors: Uchi
authors: Akiko
authors: A
authors: Hashimoto-Hachiya
authors: Masakazu
authors: M
authors: Takahara
authors: Gaku
authors: G
authors: Tsuji
authors: Makiko
authors: M
authors: Nakahara
authors: Masutaka
authors: M
authors: Furue
mesh_terms: D000975:Antioxidants; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000078404:Epidermal Cells; D000091344:Filaggrin Proteins; D015870:Gene Expression / Q000187:drug effects*; D052859:Houttuynia; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; C442781:Houttuynia cordata extract; D007381:Intermediate Filament Proteins; D051267:NF-E2-Related Factor 2; D017382:Reactive Oxygen Species; D018336:Receptors, Aryl Hydrocarbon; D014409:Tumor Necrosis Factor-alpha; D001564:Benzo(a)pyrene; D009249:NADP; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human