title: Mitochondrial tRNA mutations in patients with myelodysplastic syndromes.
abstract: Increasing evidence showed that mitochondria play an important role in the development of myelodysplastic syndromes (MDS). Mitochondrial dysfunctions caused by mitochondrial DNA mutations, especially mitochondrial tRNA mutations, were found to be associated with MDS in many studies. However, the link between a candidate mitochondrial tRNA mutation and MDS was not clear. In this study, we investigated the role of some mitochondrial tRNA mutations, and their deleterious roles were further discussed.
authors: a Department of Hematology , Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
authors: Hui-Rui
authors: HR
authors: Wang
authors: a Department of Hematology , Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
authors: Ya-Wei
authors: YW
authors: Li
authors: a Department of Hematology , Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
authors: Jun-Long
authors: JL
authors: Wu
authors: a Department of Hematology , Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , China.
authors: Shu-Li
authors: SL
authors: Guo
mesh_terms: D000483:Alleles; D019143:Evolution, Molecular; D050259:Genes, Mitochondrial; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012343:RNA, Transfer / Q000235:genetics*
chemical_list: D012343:RNA, Transfer
keywords: Association; MDS; mitochondrial tRNA mutations