title: Case series report: Early cement-implant interface fixation failure in total knee replacement.
abstract: BACKGROUND
  Early failure in cemented total knee replacement (TKR) due to aseptic loosening is uncommon. A small number of early failures requiring revision were observed at one hospital due to observed cement-implant fixation failure. The purpose of this case series is to report and identify possible causes for these early failures.
  
  
  METHODS
  Between May 2005 and December 2010, 3048 primary TKRs were performed over a five-year period of time by six surgeons. Two total knee systems were used during this period of time. Nine early failures were observed in eight patients. High viscosity cement (HVC) was used in all these cases.
  
  
  RESULTS
  Aseptic loosening of the tibial component was observed in all nine early total knee failures. The high viscosity bone cement was noted to be non-adherent to the tibial trays at the time of revision surgery. HVC was used in all these cases.
  
  
  CONCLUSIONS
  Properties of HVC may contribute to make it more susceptible to early failure in a small number of TKRs. HVC in total hip replacement (THR) has been associated with cement micro-fractures, cement debris generation and early implant failure. The mechanical properties of HVC may similarly contribute to early failure at the cement-implant interface in a small percentage TKRs.
authors: Luke Air Force Base, 56th Medical Group, Orthopaedic Surgery, Luke AFB, AZ, United States. Electronic address: khazelwoodmd@gmail.com.
authors: Kyle J
authors: KJ
authors: Hazelwood
authors: Department of Orthopaedic Surgery, Northshore University Healthsystem, Evanston, IL, United States.
authors: Michael
authors: M
authors: O'Rourke
authors: Department of Orthopaedic Surgery, Northshore University Healthsystem, Evanston, IL, United States.
authors: Van P
authors: VP
authors: Stamos
authors: Department of Orthopaedic Surgery, Northshore University Healthsystem, Evanston, IL, United States.
authors: Robert D
authors: RD
authors: McMillan
authors: Department of Orthopaedic Surgery, Northshore University Healthsystem, Evanston, IL, United States.
authors: David
authors: D
authors: Beigler
authors: Department of Orthopaedic Surgery, Northshore University Healthsystem, Evanston, IL, United States.
authors: William J
authors: WJ
authors: Robb
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D001843:Bone Cements
keywords: Aseptic loosening; Cement–implant interface; Early aseptic total knee failure; High-viscosity cement; Primary total knee arthroplasty