title: Bioengineered stem cells as an alternative for islet cell transplantation.
abstract: Type 1 diabetes is an autoimmune and increasingly prevalent condition caused by immunological destruction of beta cells. Insulin remains the mainstay of therapy. Endeavours in islet transplantation have clearly demonstrated that type 1 diabetes is treatable by cellular replacement. Many challenges remain with this approach. The opportunity to use bioengineered embryonic or adult pluripotential stem cells, or islets derived from porcine xenograft sources could address future demands, but are still associated with considerable challenges. This detailed review outlines current progress in clinical islet transplantation, and places this in perspective for the remarkable scientific advances now occurring in stem cell and regenerative medicine approaches in the treatment of future curative treatment of diabetes.
authors: Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
authors: Sarah J
authors: SJ
authors: Moore
authors: Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
authors: Boris L
authors: BL
authors: Gala-Lopez
authors: Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
authors: Andrew R
authors: AR
authors: Pepper
authors: Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
authors: Rena L
authors: RL
authors: Pawlick
authors: Sarah J Moore, Boris L Gala-Lopez, Andrew R Pepper, Rena L Pawlick, AM James Shapiro, Alberta Diabetes Institute, University of Alberta, Edmonton AB T6G 2E1, Canada.
authors: Am James
authors: AJ
authors: Shapiro
keywords: Diabetes; Hypoxia; Islet transplantation; Stem cell