title: IGFBP-rP1 suppresses epithelial-mesenchymal transition and metastasis in colorectal cancer.
abstract: Epithelial-mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-β-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer.
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: S
authors: S
authors: Zhu
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: J
authors: J
authors: Zhang
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: F
authors: F
authors: Xu
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: E
authors: E
authors: Xu
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: W
authors: W
authors: Ruan
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: Y
authors: Y
authors: Ma
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: Q
authors: Q
authors: Huang
authors: 1] Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China [2] Key Laboratory of Disease Proteomics of Zhejiang Province, Hangzhou, Zhejiang, China.
authors: M
authors: M
authors: Lai
mesh_terms: D000368:Aged; D000818:Animals; D063646:Carcinogenesis; D002465:Cell Movement / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics*; D005260:Female; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009362:Neoplasm Metastasis; D051785:Smad Proteins / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000378:metabolism*; D060449:Wnt Signaling Pathway / Q000235:genetics
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D051785:Smad Proteins; D016212:Transforming Growth Factor beta; C102529:insulin-like growth factor binding protein-related protein 1