title: Prostate carcinoma in liver transplant recipients: Think about it!
abstract: OBJECTIVE
  To analyze retrospectively our series of prostate cancer (PC) in liver transplant recipients (LTRs) given an increase in frequency in an aging recipient population when no studies were reported in literature.
  
  
  METHODS
  We conducted a retrospective analysis of LTRs in a single institution. After liver transplantation, all patients were followed up in our institution with an annual digital rectal examination by a urologist and prostate-specific antigen measurement after the age of 50 years.
  
  
  RESULTS
  Between 1995 and 2013, among 361 male LTRs, 12 (3.3%) had PC. The mean age at diagnosis was 62.8 years, and the time lapse between liver transplantation and diagnosis was 55.7 months. The median initial prostate-specific antigen level was 7.4ng/ml. In total, 9 patients underwent radical prostatectomy. Histological findings showed 5 pT2 and 4 pT3 cancers. A patient showed invasion in the lymph nodes and was treated with hormonotherapy. Another patient had a biochemical recurrence at 10 months and underwent salvage radiotherapy. After 32.9 months of follow-up, no other patients showed any recurrence. Moreover, 1 patient was treated by radiohormonotherapy for high-risk PC with no recurrence at 65 months, and 1 patient was treated with high-intensity focal ultrasound. There was 1 patient with metastatic disease who received hormonotherapy and died 5 months after diagnosis.
  
  
  CONCLUSIONS
  Our incidence of intermediate- and high-risk PCs in LTRs was slightly higher than in the general population. In the absence of any recommendations, individual screening should be proposed to LTRs. The treatment of choice remains surgery or radiotherapy to ensure a good carcinologic control.
authors: Urology and Transplantation Department, CHU de Caen, Caen, France. Electronic address: xavtillou@hotmail.com.
authors: Xavier
authors: X
authors: Tillou
authors: Surgery and Liver Transplantation Department, CHU de Bordeaux, Bordeaux, France.
authors: Laurence
authors: L
authors: Chiche
authors: Urology and Transplantation Department, CHU de Caen, Caen, France.
authors: Kerem
authors: K
authors: Guleryuz
authors: Gastroenterology and Liver Disease Department, CHU de Caen, Caen, France.
authors: Sophie
authors: S
authors: Hervé
authors: Urology Department, CHU de Bordeaux, Bordeaux, France.
authors: Henri
authors: H
authors: Bensadoun
authors: Urology and Transplantation Department, CHU de Caen, Caen, France.
authors: Arnaud
authors: A
authors: Doerfler
mesh_terms: D055088:Early Detection of Cancer; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology; D012189:Retrospective Studies
keywords: Cancer; Cancer screening; Liver transplantation; Prostate