title: Bidirectional interactions of NK cells and dendritic cells in immunotherapy: current and future perspective.
abstract: NK cells and dendritic cells (DC) are innate cellular components that regulate adaptive immune responses in the immune surveillance of cancer and infections. Interactions of NK and DC are bidirectional. In this mini review, we summarized how NK cells regulate immature DC editing and maturation, how DC regulate NK-cell functions reciprocally in the NK-DC crosstalk, and the importance of NK-DC crosstalk in antitumor immunity. Enhancing NK-DC crosstalk by cellular factor(s), antibodies or creating a microenvironment that promote NK activations, DC maturation and NK-DC crosstalk will provide new insights into future development of DC-based immunotherapy.
authors: Department of Immunology, Room 417 Apotex Center, 750 McDermot Avenue, Winnipeg, Manitoba R3E 0T5, Canada.
authors: Sajid
authors: S
authors: Mahmood
authors: Deepak
authors: D
authors: Upreti
authors: Ibrahim
authors: I
authors: Sow
authors: Abdulaziz
authors: A
authors: Amari
authors: Saravanan
authors: S
authors: Nandagopal
authors: Sam Kp
authors: SK
authors: Kung
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy
keywords: cell migration; dendritic cells; immune regulation; immunotherapy; natural killer cells