title: IL-17 and neutrophils: unexpected players in the type 2 immune response.
abstract: The study of immunity to helminth infection has been central to understanding the function of type 2 cytokines and their targets. Although type 2 cytokines are considered anti-inflammatory and promote tissue repair, they also contribute to allergy and fibrosis. Here, we utilise data from helminth infection models, to illustrate that IL-17 and neutrophils, typically associated with pro-inflammatory responses, are intimately linked with type 2 immunity. Neutrophils work with IL-4Rα-activated macrophages to control incoming larvae but this comes at a cost of enhanced tissue damage. Chitinase like proteins (CLPs) bridge these diverse outcomes, inducing both protective IL-17 and reparative Th2 responses. Dysregulation of CLPs, IL-17 and neutrophils likely contribute to disease severity and pathology associated with type 2 immunity.
authors: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, United Kingdom. Electronic address: j.allen@ed.ac.uk.
authors: Judith E
authors: JE
authors: Allen
authors: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, United Kingdom.
authors: Tara E
authors: TE
authors: Sutherland
authors: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Charlotte Auerbach Road, Edinburgh EH9 3FL, United Kingdom.
authors: Dominik
authors: D
authors: Rückerl
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D017183:Strongylida / Q000145:classification / Q000502:physiology*; D017206:Strongylida Infections / Q000276:immunology* / Q000469:parasitology
chemical_list: D016207:Cytokines; D020381:Interleukin-17