title: Autologous bone marrow mesenchymal stem cells associated with tantalum rod implantation and vascularized iliac grafting for the treatment of end-stage osteonecrosis of the femoral head.
abstract: Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients with osteonecrosis of the femoral head (ONFH) to avert the need for total hip arthroplasty (THA). However, there have been unsatisfactory success rates for end-stage ONFH. The authors describe a modified technique using bone marrow mesenchymal stem cells (BMMSCs) associated with porous tantalum rod implantation combined with vascularized iliac grafting for the treatment of end-stage ONFH. A total of 24 patients (31 hips) with end-stage ONFH were treated with surgery; ARCO IIIc stage was observed in 19 hips and ARCO IV stage was observed in 12 hips. All patients were followed for a mean time of 64.35 ± 13.03 months (range 26-78). Operations on only five hips were converted to THA. The joint-preserving success rate of the entire group was 89.47% for ARCO stage IIIc and 75% for ARCO stage IV. The mean Harris hip score of the 31 hips improved significantly from 38.74 ± 5.88 points (range 22-50) to 77.23 ± 14.75 points (range 33-95). This intervention was safe and effective in delaying or avoiding total hip replacement for end-stage ONFH.
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Dewei
authors: D
authors: Zhao
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China ; Columbia Center of Translational Immunology, Columbia University College of Physicians and Surgeons, 650 West 168th Street, New York City, NY 10032, USA.
authors: Baoyi
authors: B
authors: Liu
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Benjie
authors: B
authors: Wang
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Lei
authors: L
authors: Yang
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Hui
authors: H
authors: Xie
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Shibo
authors: S
authors: Huang
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Yao
authors: Y
authors: Zhang
authors: Department of Orthopedics, Zhongshan Hospital of Dalian University, Jiefang Street No. 6, Dalian, Liaoning 116001, China.
authors: Xiaowei
authors: X
authors: Wei
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D001854:Bone Marrow Cells / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods; D005260:Female; D005271:Femur Head Necrosis / Q000601:surgery / Q000628:therapy*; D006615:Hip / Q000601:surgery; D006801:Humans; D007085:Ilium / Q000637:transplantation*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D008875:Middle Aged; D010020:Osteonecrosis / Q000601:surgery / Q000628:therapy*; D019736:Prostheses and Implants; D013635:Tantalum / Q000627:therapeutic use*; D014182:Transplantation, Autologous / Q000379:methods; D055815:Young Adult
chemical_list: D013635:Tantalum