title: Spectrophotometric analysis of lithium carbonate used for bipolar disorder.
abstract: Lithium therapy is the gold standard of treatment for patients with Bipolar Disorder. However, despite its effectiveness, it is a potentially hazardous drug requiring regular monitoring of blood levels to ensure toxic levels are not reached. This paper describes the spectrophotometric analysis of Lithium carbonate in solution as a first step in developing a portable home monitoring device for blood lithium analysis.. Using a high-end spectrophotometer, solutions of lithium carbonate (Li2CO3) have been optically fingerprinted. Preliminary measurements indicate that the ultraviolet region shows a strong distinction between different lithium concentrations. Utilizing second derivative absorption curves, the region of 220 nm to 230 nm demonstrated the ability to differentiate between concentrations representing those found in patients. Furthermore, the method could determine to within a 1-6% accuracy whether an unknown solution of Li2CO3 is either inside or outside the high-end of the therapeutic limit.
authors: Biomedical Engineering Research Centre, School of Mathematics, Computer Science & Engineering, City University London, London, EC1V 0HB, UK.
authors: James
authors: J
authors: May
authors: Biomedical Engineering Research Centre, School of Mathematics, Computer Science & Engineering, City University London, London, EC1V 0HB, UK.
authors: Michelle
authors: M
authors: Hickey
authors: Biomedical Engineering Research Centre, School of Mathematics, Computer Science & Engineering, City University London, London, EC1V 0HB, UK.
authors: Iasonas
authors: I
authors: Triantis
authors: Centre for Psychiatry, Barts &The London School of Medicine and Dentistry, Queen Mary University, EC1M 6BQ London, UK.
authors: Eleni
authors: E
authors: Palazidou
authors: Biomedical Engineering Research Centre, School of Mathematics, Computer Science & Engineering, City University London, London, EC1V 0HB, UK.
authors: Panayiotis A
authors: PA
authors: Kyriacou
keywords: (170.0170) Medical optics and biotechnology; (170.1470) Blood or tissue constituent monitoring; (170.6510) Spectroscopy, tissue diagnostics