title: Mechanisms of a tumor marker, glutathione transferase P, expression during hepatocarcinogenesis of the rat.
abstract: The molecular mechanism of any tumor marker expression may shed a light on the mechanism of the particular tumorigenesis. This idea in mind, we have been pursuing the mechanism of specific induction of the placental type glutathione transferase (GST-P) gene during hepatocarcinogenesis of the rat. Making use of advanced technologies of molecular biology including proteomic analysis, gene cloning and production of specific transgenic rats etc., we were able to identify the enhancer and the activator proteins responsible for this tumor marker expression. Negative regulatory regions and modulatory proteins were also found. The overview of this long range study and the future outlook of the problem will be discussed.
authors: Director, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan . ; Professor Emeritus, Tokyo University School of Medicine, Tokyo, Japan .
authors: Masami
authors: M
authors: Muramatsu
authors: Professor, Dept. Health Sciences, Hokkaido University School of Medicine, Hokkaido, Japan .
authors: Masaharu
authors: M
authors: Sakai
keywords: Hepatocarcinogenesis; glutathione transferase P (GST-P); precancerous lesion; transgenic rat; tumor marker