title: Tumor-infiltrating dendritic cells in cancer pathogenesis.
abstract: Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immune-stimulatory capacity.
authors: Division of Gynecologic Surgery, Mayo Clinic, Rochester, MN 55906;
authors: Jo Marie
authors: JM
authors: Tran Janco
authors: Department of Immunology, Mayo Clinic, Rochester, MN 55906; and Cancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987.
authors: Purushottam
authors: P
authors: Lamichhane
authors: Cancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987.
authors: Lavakumar
authors: L
authors: Karyampudi
authors: Department of Immunology, Mayo Clinic, Rochester, MN 55906; and Cancer Vaccines and Immune Therapies Program, Vaccine and Gene Therapy Institute, Port St. Lucie, FL 34987 knutson.keith@mayo.edu.
authors: Keith L
authors: KL
authors: Knutson
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D007167:Immunotherapy; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D010641:Phenotype; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors