title: Shaping of the tumor microenvironment: Stromal cells and vessels.
abstract: Lymphomas develop and progress in a specialized tissue microenvironment such as bone marrow as well as secondary lymphoid organs such as lymph node and spleen. The lymphoma microenvironment is characterized by a heterogeneous population of stromal cells, including fibroblastic reticular cells, nurse-like cells, mesenchymal stem cells, follicular dendritic cells, and inflammatory cells such as macrophages, T- and B-cells. These cell populations interact with the lymphoma cells to promote lymphoma growth, survival and drug resistance through multiple mechanisms. Angiogenesis is also recognized as an important factor associated with lymphoma progression. In recent years, we have learned that the interaction between the malignant and non-malignant cells is bidirectional and resembles, at least in part, the pattern seen between non-neoplastic lymphoid cells and the normal microenvironment of lymphoid organs. A summary of the current knowledge of lymphoma microenvironment focusing on the cellular components will be reviewed here.
authors: Division of Hematology-Oncology, Department of Medicine, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, United States.
authors: Marzenna
authors: M
authors: Blonska
authors: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, United States.
authors: Nitin K
authors: NK
authors: Agarwal
authors: Division of Hematopathology, Department of Pathology, University of Miami and Sylvester Comprehensive Cancer Center, Miami, FL, United States. Electronic address: fvega@med.miami.edu.
authors: Francisco
authors: F
authors: Vega
mesh_terms: D000818:Animals; D002470:Cell Survival; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D009389:Neovascularization, Pathologic; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D059016:Tumor Microenvironment / Q000235:genetics / Q000276:immunology
keywords: Angiogenesis; Hedgehog signaling; Lymphoma microenvironment; NF-κB signaling; Stromal cells