title: Neuropeptide Y system in the retina: From localization to function.
abstract: The retina is a highly complex structure where several types of cells communicate through countless different molecules to codify visual information. Each type of cells plays unique roles in the retina, presenting a singular expression of neurotransmitters. Some neurotransmitter systems in the retina are well understood, while others need to be better explored to unravel the intricate signaling system involved. Neuropeptide Y (NPY), a 36 amino acid peptide, is one of the most common peptide neurotransmitter in the CNS and a highly conserved peptide among species. We review the localization of NPY and NPY receptors (mainly NPY Y1, Y2, Y4 and Y5) in retinal cells. Common features of the expression of NPY and NPY receptors in mammalian and non-mammalian species indicate universal roles of this system in the retina. In the present review, we highlight the putative roles of NPY receptor activation in the retina, discussing, in particular, their involvement in retinal development, neurotransmitter release modulation, neuroprotection, microglia and Muller cells function, retinal pigmented epithelium changes, retinal endothelial physiology and proliferation of retinal progenitor cells. Further studies are needed to confirm that targeting the NPY system might be a potential therapeutic strategy for retinal degenerative diseases.
authors: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal; Instituto de Educação e Cidadania, 3770-033 Mamarrosa, Portugal.
authors: Ana
authors: A
authors: Santos-Carvalho
authors: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal; Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; AIBILI-Association for Innovation and Biomedical Research on Light and Image, Azinhaga Santa Comba, 3000-548 Coimbra, Portugal.
authors: António Francisco
authors: AF
authors: Ambrósio
authors: CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal. Electronic address: ccavadas@uc.pt.
authors: Cláudia
authors: C
authors: Cavadas
mesh_terms: D000818:Animals; D006801:Humans; D009478:Neuropeptide Y / Q000502:physiology*; D017476:Receptors, Neuropeptide Y / Q000502:physiology*; D012160:Retina / Q000166:cytology / Q000502:physiology*; D055351:Retinal Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y
keywords: NPY receptors; Neuromodulation; Neuropeptide Y; Retina; Retinal cells