title: Efficacy of tobramycin aerosol in nasal polyposis.
abstract: BACKGROUND
  Treatment of infected nasal polyposis.
  
  
  METHODS
  Multicenter interventional prospective double-blind randomized study with matched groups: treatment with tobramycin aerosol versus isotonic saline aerosol. The study population included 55 patients: 23 receiving isotonic saline aerosol and 32 receiving tobramycin. A novel device (Easynose®) was used with an original principle limiting pulmonary deposition and ensuring homogeneous peripheral deposition in the nasal cavities.
  
  
  OBJECTIVE
  The principal objective was to compare bacteriological eradication between tobramycin 150mg/3ml versus isotonic saline, both administered by nebulization via the Easynose® device.
  
  
  CONCLUSIONS
  Tobramycin aerosol administered via the Easynose® device showed significantly better bacteriological eradication than isotonic saline.
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris-Descartes, Université Paris V, 20, Rue Leblanc, 75015 Paris, France. Electronic address: pierre.bonfils@egp.aphp.fr.
authors: P
authors: P
authors: Bonfils
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Centre Intercommunal de Créteil, Faculté de Médecine de Paris XII, Université Paris XII, 40, Avenue de Verdun, 94010 Créteil cedex, France.
authors: V
authors: V
authors: Escabasse
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Centre Intercommunal de Créteil, Faculté de Médecine de Paris XII, Université Paris XII, 40, Avenue de Verdun, 94010 Créteil cedex, France.
authors: A
authors: A
authors: Coste
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital, CHU Clermont-Ferrand, Université d'Auvergne, 58, Rue Montalembert, 63000 Clermont-Ferrand, France.
authors: L
authors: L
authors: Gilain
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital, CHU Clermont-Ferrand, Université d'Auvergne, 58, Rue Montalembert, 63000 Clermont-Ferrand, France.
authors: C
authors: C
authors: Louvrier
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital Larrey, CHU de Toulouse, Université de Toulouse, 24, Chemin de Pouvourville, 31400 Toulouse, France.
authors: E
authors: E
authors: Serrano
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital Larrey, CHU de Toulouse, Université de Toulouse, 24, Chemin de Pouvourville, 31400 Toulouse, France.
authors: G
authors: G
authors: de Bonnecaze
authors: Service d'ORL et de Chirurgie Cervico-Faciale, CHR de Lille, Faculté de Médecine de Lille, Université de Lille 2, 2, Avenue Oscar-Lambert, 59000 Lille, France.
authors: G
authors: G
authors: Mortuaire
authors: Service d'ORL et de Chirurgie Cervico-Faciale, CHR de Lille, Faculté de Médecine de Lille, Université de Lille 2, 2, Avenue Oscar-Lambert, 59000 Lille, France.
authors: D
authors: D
authors: Chevalier
authors: Service d'ORL et de Chirurgie Cervico-Faciale, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris-Descartes, Université Paris V, 20, Rue Leblanc, 75015 Paris, France.
authors: O
authors: O
authors: Laccourreye
authors: Service de Microbiologie, Hôpital Européen Georges-Pompidou, Faculté de Médecine Paris-Descartes, Université Paris V, 20, Rue Leblanc, 75015 Paris, France.
authors: J-L
authors: JL
authors: Mainardi
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005602:France; D006801:Humans; D007552:Isotonic Solutions / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000382:microbiology; D009298:Nasal Polyps / Q000188:drug therapy*; D059085:Nasal Sprays; D011446:Prospective Studies; D014031:Tobramycin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D007552:Isotonic Solutions; D059085:Nasal Sprays; D014031:Tobramycin
keywords: Aerosol therapy; Ethmoidectomy; Nasal polyposis; Tobramycin