title: A new triterpenoid bearing octacosanoate from the stems and roots of Clerodendrum philippinum var. simplex (Verbenaceae).
abstract: A new triterpenoid bearing octacosanoate, named taraxer-3β-yl octacosanoate (1), together with 13 known compounds (2-14), was isolated from the ethanol extract of the stems and roots of Clerodendrum philippinum var. simplex. The structure of taraxer-3β-yl octacosanoate (1) was elucidated by extensive spectroscopic analysis. Uncinatone (8) and clerodenone A (10) exhibited inhibition of lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC₅₀ values of 12.50 and 3.18 μM, respectively.
authors: a CAS Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences , Menglun, Mengla , Yunnan , 666303 , P.R. China.
authors: Jia-Rui
authors: JR
authors: Yue
authors: De-Qiang
authors: DQ
authors: Feng
authors: You-Kai
authors: YK
authors: Xu
mesh_terms: D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D002460:Cell Line; D032409:Clerodendrum / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry* / Q000302:isolation & purification; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D045784:Abietanes; D005227:Fatty Acids; D008070:Lipopolysaccharides; D014315:Triterpenes; C000601152:taraxer-3beta-yl octacosanoate; C530229:uncinatone; D009569:Nitric Oxide; C068792:octacosanoic acid
keywords: Clerodendrumphilippinum var. simplex; Dai medicine; Verbenaceae; anti-inflammatory activity; taraxer-3β-yl octacosanoate