title: Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients.
abstract: OBJECTIVE
  The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients.
  
  
  METHODS
  We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome.
  
  
  RESULTS
  There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01), blood concentrations of brain natriuretic peptide (P<0.01), reactive oxygen metabolites (markers of oxidative stress, P<0.001), and the cardio-ankle vascular index (marker of arterial function, P<0.01). Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor.
  
  
  CONCLUSIONS
  The findings of this study indicate that in vivo oxidative stress and abnormality of arterial function are closely associated with an increase in hs-cTnT concentrations in Japanese metabolic syndrome patients.
authors: Hitsumoto Medical Clinic, Yamaguchi, Japan.
authors: Takashi
authors: T
authors: Hitsumoto
authors: Department of Vascular Function (donated), Sakura Hospital, Toho University School of Medicine, Chiba, Japan.
authors: Kohji
authors: K
authors: Shirai
keywords: cardio–ankle vascular index; metabolic syndrome; oxidative stress; risk factor; troponin