title: Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups.
abstract: Four types of ligands (Q1-Q4) and their complexes (1-36) with transition metal ions have been synthesized, in which two new complexes (15 and 20) have been prepared and tested. In vitro antimicrobial activities of the ligands and their complexes were investigated against a representative panel of strains including two Gram positive bacteria (Sarcina ureae, Staphylococcus aureus), two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungi (Aspergillus niger, Saccharomyces cerevisiae, Fusarium oxysporum f. sp. cubense). The relationship between the structure and the antibacterial activities was discussed. Our study results indicated that some compounds have preferred antibacterial activities that may have potential pharmaceutical applications.
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors: Li-Jie
authors: LJ
authors: Zhang
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China. Electronic address: zhangja@126.com.
authors: Jing-An
authors: JA
authors: Zhang
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors: Xun-Zhong
authors: XZ
authors: Zou
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China; College of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors: Ya-Jie
authors: YJ
authors: Liu
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors: Ning
authors: N
authors: Li
authors: School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, People's Republic of China.
authors: Zi-Jie
authors: ZJ
authors: Zhang
authors: Department of Environmental Engineering, Guangdong Industry Technical College, Guangzhou 510300, People's Republic of China. Electronic address: liyuletter@163.com.
authors: Yu
authors: Y
authors: Li
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013329:Structure-Activity Relationship; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D011725:Pyridines; D011804:Quinolines; D028561:Transition Elements; C087618:8-mercaptoquinoline; C023666:pyridine
keywords: 8-Mercaptoquinoline; Antimicrobial effects; Pyridine; Transition metal complex