title: Atrial Fibrillation and Gastro-Oesophageal Reflux Disease - Controversies and Challenges.
abstract: Atrial fibrillation and gastro-oesophageal reflux are common manifestations in daily practice. The atria and the oesophagus are closely located and have similar nerve innervations. Over the last years, it has been observed that atrial fibrillation development and reflux disease could be related. Atrial fibrillation occurrence could be due to vagal nerve overstimulation. This, in association with vagal nerve-mediated parasympathetic stimulation, has also been observed in patients with gastro-oesophageal reflux. These mechanisms, in addition to inflammation, seem to be implicated in the pathophysiology of both diseases. Despite these associations supported by clinical and experimental studies, this relationship is still considered controversial. This review summarizes critical data regarding the association of gastro-oesophageal reflux and atrial fibrillation as well as their clinical implications.
authors: Mariana
authors: M
authors: Floria
authors: Gastroenterology and Hepathology Institute of Sf. Spiridon University Hospital Iasi, 1 Independentei Street, 700111, Iasi, Romania. oany_leo@yahoo.com.
authors: Oana
authors: O
authors: Barboi
authors: Ciprian
authors: C
authors: Rezus
authors: Valentin
authors: V
authors: Ambarus
authors: Cristina
authors: C
authors: Cijevschi-Prelipcean
authors: Gheorghe
authors: G
authors: Balan
authors: Vasile Liviu
authors: VL
authors: Drug
mesh_terms: D001281:Atrial Fibrillation / Q000150:complications* / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology; D006801:Humans