title: miR-218 suppresses cardiac myxoma proliferation by targeting myocyte enhancer factor 2D.
abstract: Cardiac myxoma is the most common type of human heart tumor, yet the molecular mechanism is still poorly understood. In the present study, we found that the level of myocyte enhancer factor 2D (MEF2D), a key regulatory protein for cardiac development, was elevated in specimens of cardiac myxoma, and was positively associated with the proliferation of myxoma cells. MEF2D suppression reduced the proliferation of myxoma cells and its tumorigenicity. Cell cycle progression was also inhibited by MEF2D suppression. miR-218, which is downregulated in myxoma, suppressed MEF2D expression by targeting its mRNA 3'UTR. Altogether, we found that miR-218/MEF2D may be an effective target for myxoma treatment.
authors: Department of Cardiovascular Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Quanxing
authors: Q
authors: Cao
authors: Department of Cardiology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Pingshuan
authors: P
authors: Dong
authors: Department of Cardiology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Yanyu
authors: Y
authors: Wang
authors: Department of Cardiovascular Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Junwei
authors: J
authors: Zhang
authors: Department of Cardiovascular Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Xinge
authors: X
authors: Shi
authors: Department of Cardiovascular Surgery, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
authors: Yongsheng
authors: Y
authors: Wang
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D002478:Cells, Cultured; D015536:Down-Regulation / Q000235:genetics; D006338:Heart Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D064326:MEF2 Transcription Factors / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D032342:Muscle Cells / Q000378:metabolism / Q000473:pathology; D009232:Myxoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D020413:3' Untranslated Regions; D064326:MEF2 Transcription Factors; C547471:MIRN218 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger