title: Immunotherapeutic approaches for cancer therapy: An updated review.
abstract: In spite of specific immune effector mechanisms raised against tumor cells, there are mechanisms employed by the tumor cells to keep them away from immune recognition and elimination; some of these mechanisms have been identified, while others are still poorly understood. Manipulation or augmentation of specific antitumor immune responses are now the preferred approaches for treatment of malignancies, and traditional therapeutic approaches are being replaced by the use of agents which potentiate immune effector mechanisms, broadly called "immunotherapy". Cancer immunotherapy is generally classified into two main classes including active and passive methods. Interventions to augment the immune system of the patient, for example, vaccination or adjuvant therapy, actively promote antitumor effector mechanisms to improve cancer elimination. On the other hand, administration of specific monoclonal antibodies (mAbs) against different tumor antigens and adoptive transfer of genetically-modified specific T cells are currently the most rapidly developing approaches for cancer targeted therapy. In this review, we will discuss the different modalities for active and passive immunotherapy for cancer.
authors: a Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Immunology , Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Tohid
authors: T
authors: Kazemi
authors: c Department of Immunology , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran.
authors: Vahid
authors: V
authors: Younesi
authors: c Department of Immunology , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran.
authors: Farhad
authors: F
authors: Jadidi-Niaragh
authors: a Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Immunology , Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors: Mehdi
authors: M
authors: Yousefi
mesh_terms: D019264:Adoptive Transfer / Q000379:methods*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000912:Antibodies, Neoplasm / Q000627:therapeutic use*; D006801:Humans; D017710:Lymphocyte Transfusion / Q000379:methods*; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000637:transplantation*
chemical_list: D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm
keywords: cancer; cancer stem cell; dendritic cell; immunotherapy; monoclonal antibody; vaccination