title: Airway response to methacholine following eucapnic voluntary hyperpnea in athletes.
abstract: OBJECTIVE
  To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes.
  
  
  METHODS
  Two MIT preceded (visit 1) or not (visit 2) by an EVH, were performed in 28 athletes and 24 non-athletes. Twelve athletes and 13 non-athletes had airway hyperresponsiveness (AHR) to methacholine, and 11 athletes and 11 non-athletes had AHR to EVH (EVH+).
  
  
  RESULTS
  The MIT PC20 post-EVH was significantly lower compared to baseline MIT PC20 by 1.3±0.7 doubling-concentrations in EVH+ athletes only (p<0.0001). No significant change was observed in EVH- athletes and EVH+/EVH- non-athletes. A significant correlation between the change in MIT PC20 post-EVH and EVH+/EVH- status and athlete/nonathlete status was found (Adjusted R2=0.26 and p<0.001). Three (11%) athletes and one (4%) non-athlete had a change in the diagnosis of AHR when MIT was performed consecutively to EVH.
  
  
  CONCLUSIONS
  The responsiveness to methacholine was increased by a previous indirect challenge in EVH+ athletes only. The mechanisms for such increase remain to be determined. MIT and EVH should ideally be performed on separate occasions as there is a small but possible risk to obtain a false-positive response to methacholine when performed immediately after the EVH.
  
  
  BACKGROUND
  ClinicalTrials.gov NCT00686491.
authors: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada; Université de Lille, EA4488 « Activité physique, muscle, santé », Lille, France.
authors: Valérie
authors: V
authors: Bougault
authors: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
authors: Evelyne
authors: E
authors: Blouin
authors: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
authors: Julie
authors: J
authors: Turmel
authors: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada.
authors: Louis-Philippe
authors: LP
authors: Boulet
mesh_terms: D056352:Athletes; D016535:Bronchial Hyperreactivity / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000187:drug effects; D015444:Exercise; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology*; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D016210:Methacholine Chloride