title: Endothelial Function in Patients with Migraine without Aura during the Interictal Period.
abstract: BACKGROUND
  In most of the studies, the association of vascular events is limited to migraine with aura or it is stronger in this group, whereas the link between migraine without aura (MO) and vascular events remained uncertain. Therefore, we decided to evaluate endothelial function by chemical and functional markers of endothelium in MO and compare with normal population.
  
  
  METHODS
  In this study, 39 patients and 25 healthy subjects were enrolled and flow-mediated dilatation (FMD), C-reactive protein (CRP), nitrite and nitrate were measured in these two groups.
  
  
  RESULTS
  The mean of FMD in healthy people was higher than the migraine patients (mean difference - 7.67%; 95% confidence interval [CI] -9.90--5.44). The means of nitrite concentration in migraineurs was significantly lower than healthy subjects (mean difference - 2.0 μmol/L; 95% CI - 3.45--0.54). But the CRP concentrations in both groups were not significantly different (mean difference 0.42 pmol/L; 95% CI - 0.13-0.98).
  
  
  CONCLUSIONS
  This study can show the endothelial dysfunction in migraineurs without aura and suggest that MO could also be a risk for cardiovascular disease.
authors: Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Kiyan
authors: K
authors: Heshmat-Ghahdarijani
authors: Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Shaghayegh Haghjooy
authors: SH
authors: Javanmard
authors: Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Seyed Ali
authors: SA
authors: Sonbolestan
authors: Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad
authors: M
authors: Saadatnia
authors: Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Seyed Ahmad
authors: SA
authors: Sonbolestan
keywords: C-reactive protein; endothelial dysfunction; flow-mediated dilatation; migraine without aura; nitric oxide