title: Hypertriglyceridemia is a potential preoperative predictor for biochemical recurrence after radical prostatectomy.
abstract: OBJECTIVE
  Many previous studies have suggested that the outcome of prostate cancer (PCa) may be closely related to abnormal lipid metabolism. Therefore, in this study, we evaluated the preoperative lipid profiles of patients with clinically localized prostate cancer (PCa) who underwent radical prostatectomy (RP), with particular emphasis on the relationship between these profiles and biochemical recurrence (BCR).
  
  
  METHODS
  We evaluated 715 consecutive men with clinically localized PCa who underwent RP at our institution between January 2011 and December 2013. We defined hypertriglyceridemia as a fasting serum triglyceride (TG) level greater than 200 mg/dL. We used the Kaplan-Meier method to predict BCR-free survival and applied the log-rank test to determine the statistical significance between survival curves. Cox proportional hazard ratio (HR) models were used to identify the significant predictors of BCR according to clinicopathological variables.
  
  
  RESULTS
  Of 663 patients who underwent RP for clinically localized PCa, 66 (10.0%) showed BCR during a median follow-up period of 21 months. Patients without BCR had higher levels of serum TG, and patients with hypertriglyceridemia were significantly more likely to achieve BCR-free survival in the Kaplan-Meier analysis (log-rank test, P = 0.009). In the multivariable analysis, the presence of hypertriglyceridemia (HR 0.22), pathologic Gleason score (≥ 8; HR 2.85), pathologic T stage (≥ pT3; HR 3.44), and a positive surgical margin (HR, 2.39) were still significant BCR predictors.
  
  
  CONCLUSIONS
  We found that preoperative hypertriglyceridemia was associated with a lower risk of BCR after RP in patients with clinically localized PCa. Our results could help to clarify the currently conflicting evidence on the relationship between serum lipid profiles, particularly the presence of hypertriglyceridemia, and the risk of BCR in PC a patients after surgery.
authors: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Minyong
authors: M
authors: Kang
authors: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Chang Wook
authors: CW
authors: Jeong
authors: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Ja Hyeon
authors: JH
authors: Ku
authors: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Choel
authors: C
authors: Kwak
authors: Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea.
authors: Hyeon Hoe
authors: HH
authors: Kim
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D053208:Kaplan-Meier Estimate; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood* / Q000175:diagnosis*; D057234:Preoperative Period; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000601:surgery*; D018709:Statistics, Nonparametric
chemical_list: D014408:Biomarkers, Tumor