title: [Perioperative management of direct oral anticoagulants: not much evidence but several different approaches].
abstract: New oral anticoagulants (NOACs) are a major step forward in the field of anticoagulation. As a consequence, the number of patients treated with NOACs that have to undergo surgery constantly increases. The optimal management of such patients is not clearly determined so far as scientifically established data are lacking. A first proposal is to mimic the perioperative management of patients on vitamin-K antagonists. When the risk of perioperative bleeding is low, NOAC intake is stopped 24 hours before surgery. If the risk of postoperative hemorrhage is moderate or high, NOAC treatment is interrupted 5 days before surgery with a low molecular weight heparin bridging whenever necessary. A second option is based on pharmacokinetic data. When the risk of perioperative bleeding is low, NOAC intake is stopped the day before surgery. If the risk of perioperative bleeding is higher, NOAC intake is suspended for 5 half lives before surgery, 48-72 hours or more. This interruption should be for a longer period in the presence of renal failure. When an unforeseen surgery is needed, the procedure must be delayed as late as possible. In case of emergency, non specific pro-hemostatic agents such as prothrombin complexes or recombinant factor VIIa have not strongly proven useful and must only be used in last ditch effort.
authors: L
authors: L
authors: Stebelski
authors: J F
authors: JF
authors: Brichant
authors: L
authors: L
authors: Piérard
authors: P
authors: P
authors: Peters
authors: M
authors: M
authors: Sénard
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D019990:Perioperative Care / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000379:methods; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D000925:Anticoagulants; D015507:Drugs, Investigational