title: Effects of post-training modafinil administration in a discriminative avoidance task in mice.
abstract: OBJECTIVE
  Although the cognitive-enhancing abilities after modafinil have been demonstrated, its effects on memory consolidation remain overlooked. We investigated the effects of repeated modafinil administration on consolidation of a discriminative avoidance task.
  
  
  METHODS
  Mice were trained in the plus-maze discriminative avoidance task. After training, mice received intraperitonial modafinil (doses of 32, 64 or 128 mg/kg). Animals were treated for more 9 consecutive days; 30 min after the last injection, testing was performed. In addition, the effects of 32 mg/kg modafinil on consolidation at different time points were examined.
  
  
  RESULTS
  The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion. Still, modafinil post-training administration at 1 or 2 h impaired memory persistence.
  
  
  CONCLUSIONS
  Modafinil impaired memory consolidation in a dose- and time-dependent fashion.
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Helaine Arrais
authors: HA
authors: Fernandes
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Karina Agustini
authors: KA
authors: Zanin
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Camilla de Lima
authors: Cde L
authors: Patti
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Leonardo Brito
authors: LB
authors: Lopes-Silva
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Carolina Souza
authors: CS
authors: Bizerra
authors: 2Department of Psychobiology,Federal University of São Paulo,SP,Brazil.
authors: Lia Rita Azeredo
authors: LR
authors: Bittencourt
authors: 2Department of Psychobiology,Federal University of São Paulo,SP,Brazil.
authors: Sergio
authors: S
authors: Tufik
authors: 1Department of Pharmacology,Federal University of São Paulo,SP,Brazil.
authors: Roberto
authors: R
authors: Frussa-Filho
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001362:Avoidance Learning / Q000187:drug effects; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced; D051379:Mice; D000077408:Modafinil; D064690:Wakefulness-Promoting Agents / Q000494:pharmacology*
chemical_list: D001559:Benzhydryl Compounds; D064690:Wakefulness-Promoting Agents; D000077408:Modafinil
keywords: anxiety; locomotion; memory consolidation; mice; modafinil