title: Covert effects of "one drink" of alcohol on brain processes related to car driving: an event-related potential study.
abstract: The effects of a low dose of alcohol on car driving remain controversial. To address this issue, event-related potentials were recorded while subjects performed a simple car-following task in a driving simulator before and after consuming either "one drink" of beer (representing one standard alcoholic beverage containing 14 g of alcohol) or mineral water (control condition). Subjects who had consumed the determined amount of alcohol demonstrated no detectable outward behavioral signs of intoxication while performing the driving task, an observation in agreement with previous findings. However, the parietal P3 elicited by the brake lights of the preceding car was significantly reduced in amplitude, approximately 50% that observed under the control condition, likely indicating alteration of the neural processing of visual information critical for safe driving. The finding suggests that alcohol begins to affect neural processes for driving even at quantities too low to modify behavior.
authors: Toyota Central R&D Labs., Inc 41-1Yokomichi, Nagakute, Aichi 480-1192, Japan.
authors: Kazutoshi
authors: K
authors: Ebe
authors: Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1-757 Asahimachi, Niigata 951-8585, Japan. Electronic address: itoh@bri.niigata-u.ac.jp.
authors: Kosuke
authors: K
authors: Itoh
authors: Department of Neurology, University of California, Davis, 150 Muir Road, Suite 127A, Martinez, CA 94553, USA.
authors: Ingrid L
authors: IL
authors: Kwee
authors: Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1-757 Asahimachi, Niigata 951-8585, Japan; Department of Neurology, University of California, Davis, 150 Muir Road, Suite 127A, Martinez, CA 94553, USA.
authors: Tsutomu
authors: T
authors: Nakada
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000503:physiopathology* / Q000523:psychology; D001334:Automobile Driving / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D000431:Ethanol / Q000494:pharmacology*; D018913:Event-Related Potentials, P300 / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D000431:Ethanol
keywords: Attention; Drinking and driving; Ethanol; P300