title: Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water.
abstract: This study highlights the potential application of antimicrobial quaternary ammonium nanomaterials for water disinfection. Quaternary ammonium polyethylenimine (QA-PEI) nanoparticles (NPs) were synthesized by polyethylenimine crosslinking and alkylation with octyl iodide followed by methyl iodide quaternization. Particles modified with octyldodecyl alkyl chains were also prepared and evaluated. The antimicrobial activity of QA-PEI NPs was studied after anchoring in non-leaching polymeric coatings and also in aqueous suspension. Particles at different loadings (w/w) were embedded in polyethylene vinyl acetate and polyethylene methacrylic acid coatings and tested for antimicrobial activity against four representative strains of bacteria in static and dynamic modes. Coatings embedded with fluorescent labelled particles tracked by Axioscope fluorescence microscope during the antimicrobial test indicates no particles leaching out. Coatings loaded with 5% w/w QA-PEI exhibited strong antibacterial activity. Aqueous suspension was tested and found effective for bacterial decontamination at 0.1 ppm and maintains its activity for several weeks.
authors: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
authors: Shady
authors: S
authors: Farah
authors: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Oren
authors: O
authors: Aviv
authors: Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Natalia
authors: N
authors: Laout
authors: Strauss-Water Co, R&D Laboratories, Petach Tikva, Israel.
authors: Stanislav
authors: S
authors: Ratner
authors: Department of Prosthodontics, Faculty of Dentistry, The Hebrew University-Hadassah, Jerusalem 91120, Israel.
authors: Nurit
authors: N
authors: Beyth
authors: Institute of Drug Research, School of Pharmacy-Faculty of Medicine, Center for Nanoscience and Nanotechnology and The Alex Grass Center for Drug Design and Synthesis, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Electronic address: avid@ekmd.huji.ac.il.
authors: Abraham J
authors: AJ
authors: Domb
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003666:Decontamination / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D052836:Heterotrophic Processes / Q000187:drug effects; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011094:Polyethyleneimine / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014871:Water Microbiology; D014876:Water Pollution
chemical_list: D000900:Anti-Bacterial Agents; D006847:Hydrocarbons, Iodinated; D011145:Polyvinyls; D000644:Quaternary Ammonium Compounds; C016438:ethylenevinylacetate copolymer; D011094:Polyethyleneimine; C014055:methyl iodide
keywords: Antimicrobial nanoparticles; Antimicrobial surface; Polyethylenimine; Water disinfection