title: Macular Thickness Profiles of Intraretinal Layers in Myopia Evaluated by Ultrahigh-Resolution Optical Coherence Tomography.
abstract: OBJECTIVE
  To investigate the thickness and variation profiles of 8 intraretinal layers in myopia.
  
  
  METHODS
  Prospective cross-sectional study.
  
  
  METHODS
  Young subjects with spherical equivalents ranging from +0.50 to -10.25 diopters and good corrected vision were divided into emmetropic (n = 20), low myopic (n = 50), and high myopic (n = 30) groups. Retinal images centered on the fovea along the horizontal and vertical meridians were obtained by ultrahigh-resolution optical coherence tomography (OCT). Macular images were segmented into 8 intraretinal layers by an automatic segmentation algorithm to yield thickness profiles within a 6-mm-diameter circle divided into central, pericentral, and peripheral regions.
  
  
  RESULTS
  For intraretinal layers in the central region, the outer segment of receptors layer was thicker in the high myopic group and positively correlated with axial length. In the pericentral and peripheral regions, all layers except the ganglion cell and inner plexiform layer had thickness changes in high myopia. The total thickness of the peripheral region was less than in the emmetropic controls owing to thinner inner nuclear layer, combined Henle fiber and outer nuclear layer, and outer segment of receptors layer. Nevertheless, the thicknesses of the combined myoid and ellipsoid zone and the combined interdigitation zone and retinal pigment epithelium/Bruch complex in the peripheral region were greater than for the emmetropic controls.
  
  
  CONCLUSIONS
  Intraretinal layer thicknesses in young high myopic eyes varied significantly from emmetropic controls, especially in the peripheral region. Ultrahigh-resolution OCT with automated segmentation can detect changes in retinal macular microstructure during the development of myopia.
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Xinting
authors: X
authors: Liu
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Meixiao
authors: M
authors: Shen
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Yimin
authors: Y
authors: Yuan
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Shenghai
authors: S
authors: Huang
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Dexi
authors: D
authors: Zhu
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Qingkai
authors: Q
authors: Ma
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Xinjie
authors: X
authors: Ye
authors: School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: lufan62@mail.eye.ac.cn.
authors: Fan
authors: F
authors: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009216:Myopia / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D009929:Organ Size; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D055351:Retinal Neurons / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult