title: The effect of statins on perioperative inflammation in cardiac and thoracic surgery.
abstract: Statins are being used with increasing frequency for indications beyond lipid-lowering therapy. In the perioperative setting, the use of statins as anti-inflammatory agents has been an area of growing interest. Despite the early clinical adoption, the data are controversial. Herein we review the available clinical trials examining the effects of statin therapy on perioperative markers of inflammation in cardiac and thoracic surgery.
authors: Division of Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI.
authors: Neel R
authors: NR
authors: Sodha
authors: Division of Cardiothoracic Surgery, Alpert Medical School of Brown University, Providence, RI. Electronic address: fsellke@lifespan.org.
authors: Frank W
authors: FW
authors: Sellke
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood; D019616:Thoracic Surgical Procedures / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018836:Inflammation Mediators