title: Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.
abstract: Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.
authors: Department of Computational Sciences, Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
authors: Samar Hayat Khan
authors: SH
authors: Tareen
authors: Department of Computational Sciences, Research Center for Modeling and Simulation (RCMS), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
authors: Jamil
authors: J
authors: Ahmad
mesh_terms: D000818:Animals; D057906:Circadian Clocks; D056925:Circadian Rhythm Signaling Peptides and Proteins / Q000378:metabolism; D003198:Computer Simulation; D004268:DNA-Binding Proteins / Q000378:metabolism; D005502:Food; D000076249:Heat Shock Transcription Factors; D022781:Hepatocytes / Q000378:metabolism*; D008322:Mammals / Q000378:metabolism; D008954:Models, Biological; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D056564:Sirtuin 1 / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D056925:Circadian Rhythm Signaling Peptides and Proteins; D004268:DNA-Binding Proteins; C000619706:HSF1 protein, human; D000076249:Heat Shock Transcription Factors; D014157:Transcription Factors; C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; C447939:SIRT1 protein, human; D056564:Sirtuin 1