title: Sclerostin and occlusion: A brief review.
abstract: In its pursuit of understanding the wonders of human body, mankind has stumbled upon yet another discovery which not only is a key to chest of unanswered queries but also opens a plethora of new possibilities. Till recently the osteocytes were considered latent cells merely entrapped in the matrix of bone. With the discovery of beta-catenin pathway and sclerostin molecule, these cells are now being recognized to perform a multitude of physiological functions which are important to bone function and turnover. Mechanosensor function of osteocytes via sclerostin molecule offers new possibilities in alveolar bone preservation. Sclerostin and its inhibitors have potential in prosthetic, regenerative and preventive therapy in dentistry. Osteocytic pathway of sclerostin release and mechanism of its interaction with occlusion is discussed in this article.
authors: Department of Periodontics, Dr. Z A Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors: Pankaj
authors: P
authors: Bansal
authors: Department of Periodontics, Dr. Z A Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors: Pritma
authors: P
authors: Singh
authors: Department of Periodontics and Community Dentistry, Dr. Z A Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors: Afshan
authors: A
authors: Bey
authors: Department of Periodontics and Community Dentistry, Dr. Z A Dental College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
authors: Narinder Dev
authors: ND
authors: Gupta
keywords: Dental occlusion; SOST protein; WNT pathway; osteocytes; sclerostin protein