title: [Case report of disseminated carcinomatosis of the bone marrow originating from gastric cancer with cancer-related disseminated intravascular coagulation successfully treated with recombinant human soluble thrombomodulin].
abstract: A 62-year-old man, who underwent distal gastrectomy due to gastric cancer, was diagnosed with disseminated carcinomatosis of the bone marrow 8 years later. Chemotherapy was administered following treatment with recombinant human soluble thrombomodulin (rTM), and as a result, he successfully recovered from his disseminated intravascular coagulation (DIC) status and experienced improvement of his severe cancer-related pain. The use of rTM may enable the safe continuation of chemotherapy, and rTM may also be a useful treatment for DIC associated with solid cancer, such as gastric cancer.
authors: Dept. of Gastroenterological Surgery and Oncology, Tazuke Kofukai Foundation, Medical Research Institute, Kitano Hospital.
authors: Hiroshi
authors: H
authors: Kawamoto
authors: Yoichiro
authors: Y
authors: Uchida
authors: Shugo
authors: S
authors: Ueda
authors: Soshi
authors: S
authors: Yanagita
authors: Hiroaki
authors: H
authors: Terajima
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011994:Recombinant Proteins / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy*; D018180:Thrombomodulin / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; C546931:THBD protein, human; D018180:Thrombomodulin