title: A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.
abstract: Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.
authors: The Key Laboratory of Life-Organic Analysis, College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China.
authors: Min
authors: M
authors: Gao
authors: Rui
authors: R
authors: Wang
authors: Fabiao
authors: F
authors: Yu
authors: Jinmao
authors: J
authors: You
authors: Lingxin
authors: L
authors: Chen
mesh_terms: D000818:Animals; D002470:Cell Survival; D015195:Drug Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D007259:Infrared Rays; D051379:Mice; D008856:Microscopy, Fluorescence; D000067996:RAW 264.7 Cells; D019265:Spectroscopy, Near-Infrared; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D013440:Sulfides; C032915:polysulfide