title: Bacterial melanin promotes recovery after sciatic nerve injury in rats.
abstract: Bacterial melanin, obtained from the mutant strain of Bacillus Thuringiensis, has been shown to promote recovery after central nervous system injury. It is hypothesized, in this study, that bacterial melanin can promote structural and functional recovery after peripheral nerve injury. Rats subjected to sciatic nerve transection were intramuscularly administered bacterial melanin. The sciatic nerve transected rats that did not receive intramuscular administration of bacterial melanin served as controls. Behavior tests showed that compared to control rats, the time taken for instrumental conditioned reflex recovery was significantly shorter and the ability to keep the balance on the rotating bar was significantly better in bacterial melanin-treated rats. Histomorphological tests showed that bacterial melanin promoted axon regeneration after sciatic nerve injury. These findings suggest that bacterial melanin exhibits neuroprotective effects on injured sciatic nerve, contributes to limb motor function recovery, and therefore can be used for rehabilitation treatment of peripheral nerve injury.
authors: Institute of Physiology, National Academy of Sciences of Armenia, Orbeli str. 22, Yerevan, Armenia.
authors: Olga V
authors: OV
authors: Gevorkyan
authors: Institute of Physiology, National Academy of Sciences of Armenia, Orbeli str. 22, Yerevan, Armenia.
authors: Irina B
authors: IB
authors: Meliksetyan
authors: Department of Kinesiology, Armenian State Institute of Physical Culture, Alex Manukyan 11, Yerevan, Armenia.
authors: Tigran R
authors: TR
authors: Petrosyan
authors: Scientific and Production Center "Armbiotechnology", National Academy of Sciences of Armenia, Yerevan, Armenia.
authors: Anichka S
authors: AS
authors: Hovsepyan
keywords: bacterial melanin; behaviors; histomorphology; motor function; nerve regeneration; neural regeneration; peripheral nerve injury; sciatic nerve injury