title: The expression levels of JunB, JunD and p-c-Jun are positively correlated with tumor cell proliferation in diffuse large B-cell lymphomas.
abstract: We analyzed the expression of Jun family in relation to CD30 expression, cell proliferation and B-cell differentiation immunophenotypes [Germinal Center and non-Germinal Center] in diffuse large B-cell lymphomas (DLBCL). Expression and high expression of phosphorylated-c-Jun (p-c-Jun), JunB, JunD and CD30 (cut-off scores 20% and 50%, respectively) was found in 18/103, 49/103, 72/101 and 26/102 cases, respectively, and in 6/103, 27/103, 60/101 and 21/102 cases, respectively. The following significant positive correlations were observed: (a) JunB with cyclin A (p = 0.046), cyclin B1 (p = 0.033), cyclin E (p = 0.003), MUM-1 (p = 0.002) and CD30 (p < 0.001), (b) JunD with Ki67 (p = 0.002) and cyclin E (p = 0.014), (c) p-c-Jun with CD30 (p = 0.015), and (d) high p-c-Jun with cyclin A (p = 0.034). The positive correlation between expression of JunB, JunD and p-c-Jun and tumor cell proliferation in DLBCL, suggests that increased JunB, JunD and p-c-Jun expression may be involved in the pathogenesis of DLBCL by increasing tumor cell proliferation.
authors: a Department of Pathology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Alexandra
authors: A
authors: Papoudou-Bai
authors: a Department of Pathology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Anna
authors: A
authors: Goussia
authors: a Department of Pathology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Anna
authors: A
authors: Batistatou
authors: a Department of Pathology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Dimitrios
authors: D
authors: Stefanou
authors: a Department of Pathology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Vassiliki
authors: V
authors: Malamou-Mitsi
authors: b Department of Anatomy-Histology-Embryology , Medical Faculty , University of Ioannina, Ioannina , Greece.
authors: Panagiotis
authors: P
authors: Kanavaros
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D049109:Cell Proliferation; D016000:Cluster Analysis; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D060787:Neoplasm Grading; D010641:Phenotype; D010766:Phosphorylation; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D016755:Proto-Oncogene Proteins c-jun
keywords: Cell cycle and apoptosis changes; Lymphoma and Hodgkin disease; Morphology