title: Paper-Based Systems for Point-of-Care Biosensing.
abstract: Paper-based systems have been widely investigated for developing point-of-care devices because of their simplicity, affordability, and ease of use. Recent advances have resulted in paper systems that have progressed beyond the historical "single-strip" format and allow for a larger range of functions. This review provides a summary of the advances that have been made to improve the utility of paper-based diagnostic tests for biosensing. Specifically, techniques for designing paper devices, including different geometries and chemical patterning to control fluid flow, are discussed. This review also examines novel approaches to improve paper-based assay sensitivities, such as sample preconcentration, signal amplification at the detection zone, and electrochemical methods.
authors: Department of Bioengineering, University of California, Los Angeles, CA, USA.
authors: Sherine F
authors: SF
authors: Cheung
authors: Department of Bioengineering, University of California, Los Angeles, CA, USA.
authors: Samantha K L
authors: SK
authors: Cheng
authors: Department of Bioengineering, University of California, Los Angeles, CA, USA kamei@seas.ucla.edu.
authors: Daniel T
authors: DT
authors: Kamei
mesh_terms: D015374:Biosensing Techniques; D004867:Equipment Design; D006801:Humans; D046210:Microfluidic Analytical Techniques; D010209:Paper; D019095:Point-of-Care Systems
keywords: 2D Paper Network; aqueous two-phase systems; electrochemical; lateral-flow immunoassay; µPAD