title: Monoamine oxidase a gene polymorphisms and bipolar disorder in Iranian population.
abstract: BACKGROUND
  Bipolar disorder (BPD) is a common and severe mood disorder. Although genetic factors have important rolesin the etiology of bipolar disorder, no specific gene has been identified in relation to this disorder. Monoamine oxidase gene is suggested to be associated with bipolar disorder in many studies.
  
  
  OBJECTIVE
  This study aimed to investigatethe role of MAOA gene polymorphisms in the etiology of bipolar disorder in Iranian population.
  
  
  METHODS
  This study is a case-control study, with convenient sampling. Three common polymorphisms, a CA microsatellite, a VNTR, and a RFLP were typed in 156 bipolar patients and 173 healthy controls. Patients were chosen from Imam Hossein General Hospital, Psychiatry Ward (Tehran/Iran). Controlsamples for this study consisted of 173 healthy individuals recruitedby convenient sampling. Allelic distributions of these polymorphisms were analyzed in bipolar and control groups to investigate any association with MAOA gene.
  
  
  RESULTS
  Significant associations were observed regarding MAOA-CA (P = 0.016) and MAOA-VNTR (P = 0.004) polymorphisms in the bipolar females. There was no association between MAOA-RFLP and bipolar disorder.
  
  
  CONCLUSIONS
  The obtained results confirm some previous studies regardinga gender specific association of MAOA gene with the bipolar disorder.
authors: Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Mohammad Reza
authors: MR
authors: Eslami Amirabadi
authors: Behavioral Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Sepideh
authors: S
authors: Rajezi Esfahani
authors: Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Rozita
authors: R
authors: Davari-Ashtiani
authors: Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Mojgan
authors: M
authors: Khademi
authors: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Babak
authors: B
authors: Emamalizadeh
authors: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Abolfazl
authors: A
authors: Movafagh
authors: Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Said
authors: S
authors: Sadr
authors: Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Fariba
authors: F
authors: Arabgol
authors: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors: Hossein
authors: H
authors: Darvish
authors: Department of Psychiatry, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors: Katayoon
authors: K
authors: Razjoyan
keywords: Bipolar Disorder; Genetic Association Studies; Genetics; Iran; Monoamine Oxidase