title: Substrates for clinical applicability of stem cells.
abstract: The capability of human pluripotent stem cells (hPSCs) to differentiate into a variety of cells in the human body holds great promise for regenerative medicine. Many substrates exist on which hPSCs can be self-renewed, maintained and expanded to further the goal of clinical application of stem cells. In this review, we highlight numerous extracellular matrix proteins, peptide and polymer based substrates, scaffolds and hydrogels that have been pioneered. We discuss their benefits and shortcomings and offer future directions as well as emphasize commercially available synthetic peptides as a type of substrate that can bring the benefits of regenerative medicine to clinical settings.
authors: Sanjar Enam, Sha Jin, Department of Biomedical Engineering, Thomas J Watson School of Engineering and Applied Sciences, State University of New York in Binghamton, Binghamton, NY 13902, United States.
authors: Sanjar
authors: S
authors: Enam
authors: Sanjar Enam, Sha Jin, Department of Biomedical Engineering, Thomas J Watson School of Engineering and Applied Sciences, State University of New York in Binghamton, Binghamton, NY 13902, United States.
authors: Sha
authors: S
authors: Jin
keywords: Extracellular matrix protein; Human pluripotent stem cells; Hydrogel; Peptide; Polymer; Scaffold; Synthetic substrate