title: [A case of ampullary carcinoma progression-free for four years after treatment with TS-1].
abstract: A 63-year old man was referred to our hospital because of fever, appetite loss, and increased biliary enzyme levels. Upper gastrointestinal endoscopy revealed a tumor in the duodenal papilla, diagnosed as an adenocarcinoma via biopsy, and computed tomography (CT) revealed multiple tumors in the liver. Chemotherapy with TS-1 was initiated based on a diagnosis of ampullary cancer with multiple liver metastases. After TS-1 treatment, the multiple tumors were no longer detectable, and the primary tumor did not increase in size for 4 years. At this time, however, the patient experienced fever, jaundice, and appetite loss. The hepatic mass was not detected via CT or MRI. The primary tumor was determined to be resectable; therefore, we performed subtotal stomach preserving pancreatoduodenectomy. The patient was discharged 55 days after surgery and is alive without recurrence 2 years after surgery.
authors: Dept. of Surgery, Yamagata Prefectural Central Hospital.
authors: Naoki
authors: N
authors: Mori
authors: Naoki
authors: N
authors: Sakurai
authors: Hajime
authors: H
authors: Iizawa
mesh_terms: D014670:Ampulla of Vater / Q000473:pathology*; D018450:Disease Progression; D004379:Duodenal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008875:Middle Aged; D016577:Pancreaticoduodenectomy; D017640:Silicates / Q000627:therapeutic use*; D014025:Titanium / Q000627:therapeutic use*
chemical_list: D017640:Silicates; C103828:titanium silicide; D014025:Titanium