title: Considerations and management of a patient with three metachronous cancers in association with Lynch syndrome and ileal Crohn's disease: A case report.
abstract: BACKGROUND
  Lynch syndrome and Crohn's disease are two entirely separate conditions but each have major gastrointestinal characteristics and carry a substantial increase in the risk of intestinal malignancy. Their co-existence in the patient who is the subject of this report dictated the need for an individualised treatment plan to deal with both conditions adequately.
  
  
  METHODS
  We report a case of a 51 year old female with a past medical history that includes Lynch syndrome and small bowel Crohn's disease. Over a period of fifteen months, she developed three separate primary metachronous tumors in her endometrium, colon and duodenum.
  
  
  CONCLUSIONS
  A patient with a combination of Lynch syndrome and ileal Crohn's disease presents significant therapeutic implications that are not usually present when these conditions are treated in isolation.
  
  
  CONCLUSIONS
  The surgical treatment of patients with Lynch syndrome requires a sound knowledge of the possible neoplastic conditions that can arise in the syndrome. Early detection is paramount, either by implementation of evidence based surveillance programs or at least by a heightened clinical awareness of the features of this disease. Ideally this will result in both reduced surgical morbidity and improved oncologic outcome. Furthermore, the medical treatment of Crohn's disease in a patient with tumors arising from Lynch syndrome must be undertaken with at least a consideration of the possibility that the use of immunosuppressive medication might increase the risk of cancer recurrence.
authors: Colorectal Surgery Unit, Royal Melbourne Hospital, Grattan St, Parkville, Victoria 3050, Australia. Electronic address: klourensz@me.com.
authors: Kaleb
authors: K
authors: Lourensz
authors: Colorectal Surgery Unit, Royal Melbourne Hospital, Grattan St, Parkville, Victoria 3050, Australia; Clinical Professorial Fellow, Department of Surgery, The University of Melbourne, Victoria 3050, Australia.
authors: Ian
authors: I
authors: Jones
keywords: Colon cancer; Crohn’s disease; Endometrial cancer; HNPCC; Lynch syndrome; Small bowel cancer