title: Clopidogrel resistance after renal transplantation.
abstract: BACKGROUND
  Leading causes of mortality and morbidity after kidney transplantation are cardiovascular diseases. One of the fundamentals of their prevention is the inhibition of platelet aggregation. Resistance to anti-platelet agents is a well-established phenomenon; however, its causes are yet to be clarified.
  
  
  METHODS
  Forty post-transplant patients, who received 75 mg clopidogrel q.d. as a prophylactic measure, were examined using optical aggregometry. Subsequently, logistic regression analysis was performed with 24 variables in order to expose possible causes of resistance.
  
  
  RESULTS
  Sixty percent of patients (24) were resistant to clopidogrel therapy; effective thrombocyte inhibition could only be shown in 40% of them (16). Significant correspondence between resistance and variables could not be found.
  
  
  CONCLUSIONS
  Clopidogrel resistance is expected to occur on a large scale in patients who underwent kidney transplant surgery. Thus, a key component of preventive therapy, which stresses the importance of discovering the cause of resistance so as to decrease mortality rates, is missing.
authors: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Adam
authors: A
authors: Varga
authors: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Barbara
authors: B
authors: Sandor
authors: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Karoly Kalmar
authors: KK
authors: Nagy
authors: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Dora
authors: D
authors: Praksch
authors: Department of Public Health Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Katalin
authors: K
authors: Gombos
authors: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Andras
authors: A
authors: Toth
authors: First Department of Medicine, University of Pecs, School of Medicine, Pecs, Hungary.
authors: Kalman
authors: K
authors: Toth
authors: Department of Surgery, University of Pecs, School of Medicine, Pecs, Hungary drszakalyp@t-online.hu.
authors: Peter
authors: P
authors: Szakaly
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D000077144:Clopidogrel; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
keywords: Cardiovascular complication; clopidogrel resistance; platelet aggregation; transplantation