title: Regulation of stem cell fate by nanomaterial substrates.
abstract: Stem cells are increasingly studied because of their potential to underpin a range of novel therapies, including regenerative strategies, cell type-specific therapy and tissue repair, among others. Bionanomaterials can mimic the stem cell environment and modulate stem cell differentiation and proliferation. New advances in these fields are presented in this review. This work highlights the importance of topography and elasticity of the nano-/micro-environment, or niche, for the initiation and induction of stem cell differentiation and proliferation.
authors: Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, PO Box 14177-55469, Tehran, Iran.
authors: Omid
authors: O
authors: Mashinchian
authors: Lesley-Anne
authors: LA
authors: Turner
authors: Matthew J
authors: MJ
authors: Dalby
authors: Sophie
authors: S
authors: Laurent
authors: Mohammad Ali
authors: MA
authors: Shokrgozar
authors: Shahin
authors: S
authors: Bonakdar
authors: Mohammad
authors: M
authors: Imani
authors: Morteza
authors: M
authors: Mahmoudi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D002454:Cell Differentiation; D060846:Cell Engineering; D049109:Cell Proliferation; D006801:Humans; D050997:Nanomedicine; D049329:Nanostructures; D015398:Signal Transduction; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
chemical_list: D001672:Biocompatible Materials
keywords: biomimicking; differentiation; nanotechnology; niche; stem cells; substrates