title: Light and heavy chain deposition disease associated with CH1 deletion.
abstract: Light and heavy chain deposition disease (LHCDD) is a rare complication of monoclonal gammopathy. In all documented cases, LHCDD is the association of deposits of a monoclonal light chain with a normal heavy chain, especially in the kidneys. We describe here a 78-year-old woman whose renal biopsy showed nodular glomerulosclerosis, initially diagnosed as diabetic nephropathy. Detailed kidney biopsy immunofluorescence study corrected the diagnosis to γ1-κ-LHCDD. Advanced immunoblot analysis showed deletion of CH1 in the both blood and kidney heavy chain. We report here, to our knowledge, the first case of γ1 LHCDD associated with a deletion of CH1.
authors: Service de néphrologie , hôpital Necker , Paris , France.
authors: Camille
authors: C
authors: Cohen
authors: Service de néphrologie , hôpital Necker , Paris , France.
authors: Khalil
authors: K
authors: El-Karoui
authors: Service d'immunologie , hôpital Necker , Paris , France.
authors: Marie-Alexandra
authors: MA
authors: Alyanakian
authors: Service d'anatomo-pathologie , hôpital Necker , Paris , France.
authors: Laure-Hélène
authors: LH
authors: Noel
authors: Service de néphrologie , CHU Poitiers , Poitiers , France.
authors: Franck
authors: F
authors: Bridoux
authors: Service de néphrologie , hôpital Necker , Paris , France.
authors: Bertrand
authors: B
authors: Knebelmann
keywords: MGRS; MIDD; chronic kidney disease; monoclonal gammopathy; multiple myeloma