title: Optimization of solid-supported Glaser-Hay reactions in the microwave.
abstract: The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.
authors: Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA. jslampkowski@email.wm.edu.
authors: Jessica S
authors: JS
authors: Lampkowski
authors: Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA. jcmaza@email.wm.edu.
authors: Johnathan C
authors: JC
authors: Maza
authors: Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA. sverma01@email.wm.edu.
authors: Sanjana
authors: S
authors: Verma
authors: Department of Chemistry, College of William & Mary, P.O. Box 8795, Williamsburg, VA 23187, USA. dyoung01@wm.edu.
authors: Douglas D
authors: DD
authors: Young
mesh_terms: D002384:Catalysis; D053280:Diynes / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D013997:Time Factors
chemical_list: D053280:Diynes