title: From local to global changes in proteins: a network view.
abstract: To fulfill the biological activities in living organisms, proteins are endowed with dynamics, robustness and adaptability. The three properties co-exist because they allow global changes in structure to arise from local perturbations (dynamics). Robustness refers to the ability of the protein to incur such changes without suffering loss of function; adaptability is the emergence of a new biological activity. Since loss of function may jeopardize the survival of the organism and lead to disease, adaptability may occur through the combination of two local perturbations that together rescue the initial function. The review highlights the relevancy of computational network analysis to understand how a local change produces global changes.
authors: Laboratoire de Mathématiques (LAMA UMR 5127), Université Savoie Mont Blanc, CNRS, Le Bourget du Lac, France.
authors: Laurent
authors: L
authors: Vuillon
authors: UGA-CNRS AGIM FRE3405, IXXI, Ecole Normale Supérieure de Lyon, France. Electronic address: claire.lesieur@ens-lyon.fr.
authors: Claire
authors: C
authors: Lesieur
mesh_terms: D000596:Amino Acids; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000596:Amino Acids; D011506:Proteins