title: Role of endogenous pain modulation in chronic pain mechanisms and treatment.
abstract: Development and application of psychophysical test paradigms to assess endogenous pain modulation in healthy controls and in patients yielded large body of data over the last 2 decades. These tests can assist in predicting pain acquisition, in characterizing pain syndromes and related dysfunctions of pain modulation, and in predicting response to treatment. This chapter reviews the development of thought on pain modulation in the clinical setup, focusing on conditioned pain modulation, and update on accumulated data regarding the mechanism, protocols of administration, and applications in the clinic.
authors: Department of Neurology, Rambam Health Care Campus, and Clinical Neurophysiology Laboratory, Technion Faculty of Medicine, Haifa, Israel.
authors: David
authors: D
authors: Yarnitsky
mesh_terms: D000818:Animals; D059333:Central Nervous System Sensitization / Q000502:physiology*; D059350:Chronic Pain / Q000628:therapy*; D003213:Conditioning, Psychological; D006801:Humans; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology