title: Ratiometric detection of oligonucleotide stoichiometry on multifunctional gold nanoparticles by whispering gallery mode biosensing.
abstract: A label-free method is developed to ratiometrically determine the stoichiometry of oligonucleotides attached to the surface of gold nanoparticle (GNP) by whispering gallery mode biosensing. Utilizing this scheme, it is furthermore shown that the stoichiometric ratio of GNP attached oligonucleotide species can be controlled by varying the concentration ratio of thiolated oligonucleotides that are used to modify the GNP.
authors: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors: F C
authors: FC
authors: Wu
authors: Y
authors: Y
authors: Wu
authors: Z
authors: Z
authors: Niu
authors: F
authors: F
authors: Vollmer
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000032:analysis*
chemical_list: D009841:Oligonucleotides; D006046:Gold; D004247:DNA