title: Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury.
abstract: Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived neurotrophic factor expression. In addition, the number of cells double-labeled for 5-bromodeoxyuridine/glial fibrillary acidic protein and cells expressing nestin increased. Finally, blood vessels were newly generated, and the rats exhibited improved motor and cognitive functions. These results suggested that transplantation of autologous bone marrow-derived mesenchymal stem cells promoted brain remodeling and improved neurological functions following traumatic brain injury.
authors: Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors: Jindou
authors: J
authors: Jiang
authors: Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
authors: Xingyao
authors: X
authors: Bu
authors: Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
authors: Meng
authors: M
authors: Liu
authors: Department of Neurosurgery, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China.
authors: Peixun
authors: P
authors: Cheng
keywords: angiogenesis; bone marrow-derived mesenchymal stem cells; neural regeneration; neurogenesis; neurotrophic factors; stem cell transplantation; traumatic brain injury