title: [Effects of APOC3 polymorphisms on the plasma lipids in healthy adolescents with different body mass index].
abstract: OBJECTIVE
  To investigate the possible effects of apolipoprotein C I gene (APOC3) polymorphisms on plasma lipids in healthy adolescents with different body mass index (BMI).
  
  
  METHODS
  Seven hundred and twenty three adolescents were divided into four groups according to BMI: group 1 CBMI= (17.80 +/- 0.75) kg/m2,n=180], group 2 [BMI = (19.39 +/- 0.32) kg/m2, n=182), group 3 [BMI= (20.68 +/- 0.43) kg/m2, n=1813 and group 4 [BMI= (23.40 +/- 2.05) kg/m2 ,n=180J. Fasting venous blood samples were collected, plasma lipids were determined and genome DNA was extracted for determining the genotypes of the APOC3 Sst I and -482C>T polymorphisms by PCR-RFLP.
  
  
  RESULTS
  With the elevation of BMI, height and plasma high-density lipoprotein cholesterol decreased significantly (P<0.001 for both), body mass, waist circumference, hip circumference, waist/hip ratio, plasma triglycerides (TG), total cholesterol and low-density lipoprotein cholesterol levels increased significantly (P<0.001 for all). No significant differences in TG levels among Sst I genotypes were observed in group 1, group 2 and group 3; but in group 4, significant differences in TG levels among Sst I genotypes were observed, S2 carriers had higher TG levels than the adolescents with S1S1 genotype. No significant differences in plasma lipids among -482C>T genotypes were observed in all groups.
  
  
  CONCLUSIONS
  The elevation of plasma TG levels by the S2 allele of APOC3 Sst I polymorphism is associated with BMI. It is possible that the reduction of body mass could favorably modulate the elevation of TG levels by S2 allele in healthy adolescents.
authors: Yong-yan
authors: YY
authors: Song
authors: Ren-rong
authors: RR
authors: Gong
authors: Zhen
authors: Z
authors: Zhang
authors: Yuan-hao
authors: YH
authors: Li
authors: Mei
authors: M
authors: Fan
authors: Min-shan
authors: MS
authors: Hu
authors: Ding-zhi
authors: DZ
authors: Fang
mesh_terms: D000293:Adolescent; D000483:Alleles; D053305:Apolipoprotein C-III / Q000235:genetics*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood*; D005838:Genotype; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood*; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D053305:Apolipoprotein C-III; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol