title: Frequency-dependent changes of local resting oscillations in sleep-deprived brain.
abstract: Sleep deprivation (SD) adversely affects brain function and is accompanied by frequency dependent changes in EEG. Recent studies have suggested that BOLD fluctuations pertain to a spatiotemporal organization with different frequencies. The present study aimed to investigate the frequency-dependent SD-related brain oscillatory activity by using the amplitude of low-frequency fluctuation (ALFF) analysis. The ALFF changes were measured across different frequencies (Slow-4: 0.027-0.073 Hz; Slow-5: 0.01-0.027 Hz; and Typical band: 0.01-0.08 Hz) in 24 h SD as compared to rested wakeful during resting-state fMRI. Sixteen volunteers underwent two fMRI sessions, once during rested wakefulness and once after 24 h of SD. SD showed prominently decreased ALFF in the right inferior parietal lobule (IPL), bilateral orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex (DLPFC), while increased ALFF in the visual cortex, left sensorimotor cortex and fusiform gyrus. Across the Slow-4 and Slow-5, results differed significantly in the OFC, DLPFC, thalamus and caudate in comparison to typical frequency band; and Slow-4 showed greater differences. In addition, negative correlations of behavior performance and ALFF patterns were found mainly in the right IPL across the typical frequency band. These observations provided novel insights about the physiological responses of SD, identified how it disturbs the brain rhythms, and linked SD with frequency-dependent alterations in amplitude patterns.
authors: Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors: Lei
authors: L
authors: Gao
authors: The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.
authors: Lijun
authors: L
authors: Bai
authors: Zonglian Experimental Class, Xi'an Jiaotong University, Xi'an, China.
authors: Yuchen
authors: Y
authors: Zhang
authors: Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors: Xi-jian
authors: XJ
authors: Dai
authors: Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Rana
authors: R
authors: Netra
authors: Acupuncture & Rehabilitation Department, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.
authors: Youjiang
authors: Y
authors: Min
authors: Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors: Fuqing
authors: F
authors: Zhou
authors: Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Chen
authors: C
authors: Niu
authors: Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Wanghuan
authors: W
authors: Dun
authors: Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
authors: Honghan
authors: H
authors: Gong
authors: Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
authors: Ming
authors: M
authors: Zhang
mesh_terms: D001931:Brain Mapping; D058256:Brain Waves; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology; D066191:Sensorimotor Cortex / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology*; D013788:Thalamus / Q000502:physiology; D055815:Young Adult