title: Effect of sugarcane biopolymer in vocal fold of rabbits. Comparative study with calcium hydroxyapatite.
abstract: OBJECTIVE
  To compare the inflammatory reaction caused by the injection of a sugarcane biopolymer (SCB) into the vocal fold of rabbits with that caused by calcium hydroxyapatite (CaH).
  
  
  METHODS
  CaH (Radiesse(r)) and SCB gel were injected respectively into the right and left vocal cords of thirty rabbits. The rabbits were distributed into two equal groups and sacrificed at three and twelve weeks after injection. We then evaluated the intensity of the inflammatory reaction, plus levels of neovascularization, fibrogenesis and inflammatory changes in the vocal mucosa.
  
  
  RESULTS
  The vocal cords injected with CaH had a stronger inflammatory reaction by giant cells in both study periods. The SCB group had a more intense inflammatory involvement of polymorphonuclear cells three weeks after injection. SCB caused a higher level of neovascularization compared with CaH three weeks after the procedure.
  
  
  CONCLUSIONS
  Whereas calcium hydroxyapatite triggers a more intense and lasting inflammatory reaction mediated by giant cells, sugarcane biopolymer causes a greater response from polymorphonuclear leukocytes, as well as higher levels of vneoascularization three weeks after injection.
authors: University of Sao Paulo, Brazil.
authors: Silvio José de
authors: SJ
authors: Vasconcelos
authors: Department of Otolaryngology and Head and Neck Surgery, Agamenon Magalhaes Hospital, Recife, PE, Brazil.
authors: Rodrigo Augusto Souza
authors: RA
authors: Leão
authors: Department of Pathology, Federal University of Pernambuco, Brazil.
authors: Sidcley
authors: S
authors: Bernardino-Araújo
authors: Department of Pathology, UFPE, Recife, PE, Brazil.
authors: Mariana Montenegro de Melo
authors: MM
authors: Lira
authors: Department of Otolaryngology, USP, Sao Paulo, SP, Brazil.
authors: Domingos Hiroshi
authors: DH
authors: Tsuji
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D001704:Biopolymers / Q000009:adverse effects*; D017886:Durapatite / Q000009:adverse effects*; D005355:Fibrosis; D015726:Giant Cells / Q000187:drug effects / Q000473:pathology; D007267:Injections; D007827:Laryngitis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009389:Neovascularization, Pathologic; D011817:Rabbits; D011897:Random Allocation; D031786:Saccharum / Q000737:chemistry*; D012720:Severity of Illness Index; D013997:Time Factors; D014827:Vocal Cords / Q000187:drug effects* / Q000473:pathology
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D017886:Durapatite