title: Reliable femoral chronic total occlusion model using a thin biodegradable polymer coated copper stent in a porcine model.
abstract: Chronic total occlusions (CTOs) are common in patients with peripheral arterial disease (PAD). This study aimed to examine the feasibility and reliability of a CTO induced by a thin biodegradable polymer (polyglycolic acid) coated copper stent in a porcine femoral artery. Novel thin biodegradable polymer coated copper stents (9 mm long) were crimped on an angioplasty balloon (4.5 mm diameter × 12 mm length) and inserted into the femoral artery. Histopathologic analysis was performed 35 days after stenting. In five of six stented femoral arteries, severe in-stent restenosis and total occlusion with collateral circulation were observed without adverse effects such as acute stent thrombosis, leg necrosis, or death at 5 weeks. Fibrous tissue deposition, small vascular channels, calcification, and inflammatory cells were observed in hematoxylin-eosin, Carstair's, and von Kossa tissue stains; these characteristics were similar to pathological findings associated with CTOs in humans. The neointima volume measured by micro-computed tomography was 93.9 ± 4.04 % in the stented femoral arteries. CTOs were reliably induced by novel thin biodegradable polymer coated copper stents in porcine femoral arteries. Successful induction of CTOs may provide a practical understanding of their formation and application of an interventional device for CTO treatment.
authors: Cardiovascular Convergence Research Center Nominated by Korea Ministry of Health and Welfare, Gwangju, Korea.
authors: Nan Yeol
authors: NY
authors: Kim
authors: Kyung Seob
authors: KS
authors: Lim
authors: Myung Ho
authors: MH
authors: Jeong
authors: In Ho
authors: IH
authors: Bae
authors: Jun-Kyu
authors: JK
authors: Park
authors: Jae-Woon
authors: JW
authors: Nah
authors: Dae Sung
authors: DS
authors: Park
authors: So Youn
authors: SY
authors: Lee
authors: Eun Jae
authors: EJ
authors: Jang
authors: Jong Min
authors: JM
authors: Kim
authors: Jung Ha
authors: JH
authors: Kim
authors: Hae Jin
authors: HJ
authors: Kee
authors: Soo-Na
authors: SN
authors: Cho
authors: Doo Sun
authors: DS
authors: Sim
authors: Keun-Ho
authors: KH
authors: Park
authors: Young Joon
authors: YJ
authors: Hong
authors: Sang-Gi
authors: SG
authors: Oh
authors: Sang-Hyung
authors: SH
authors: Kim
authors: Youngkeun
authors: Y
authors: Ahn
authors: Jung Chaee
authors: JC
authors: Kang
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000473:pathology / Q000503:physiopathology; D006083:Graft Occlusion, Vascular / Q000473:pathology* / Q000503:physiopathology; D011100:Polyglycolic Acid / Q000737:chemistry*; D015607:Stents; D013552:Swine
chemical_list: D020099:Coated Materials, Biocompatible; D011100:Polyglycolic Acid; D003300:Copper