title: Synthetic approaches to the 2013 new drugs.
abstract: New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of twenty-four NCEs that were approved for the first time in 2013 and two 2012 drugs which were not covered during the previous edition of this review.
authors: Pharmacodia (Beijing) Co., Ltd, Beijing 100085, China. Electronic address: Sheryl.ding@pharmacodia.com.
authors: Hong X
authors: HX
authors: Ding
authors: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: carolyn.a.leverett@pfizer.com.
authors: Carolyn A
authors: CA
authors: Leverett
authors: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: robert.kynejr@pfizer.com.
authors: Robert E
authors: RE
authors: Kyne
authors: Lilly China Research and Development Center, Shanghai 201203, China. Electronic address: Liu_kang_zhi_kevin@lilly.com.
authors: Kevin K-C
authors: KK
authors: Liu
authors: BioDuro Co., Ltd, Shanghai 200131, China. Electronic address: Sarah.fink@bioduro.com.
authors: Sarah J
authors: SJ
authors: Fink
authors: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: andrew.flick@pfizer.com.
authors: Andrew C
authors: AC
authors: Flick
authors: Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States. Electronic address: christopher.j.odonnell@pfizer.com.
authors: Christopher J
authors: CJ
authors: O'Donnell
mesh_terms: D015195:Drug Design; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations
keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents