title: Antimicrobial susceptibility of Leptospira isolates from dogs and rats to 12 antimicrobial agents.
abstract: This study determined the antimicrobial susceptibilities of 67 isolates of Leptospira from dogs (suspect canine cases: n=7 and stray dogs: n=6) and rodents (n=54) in Trinidad to 12 antimicrobial agents using broth microdilution and macrodilution techniques. Commonly used antimicrobial agents such as the penicillin G and ceftriaxone had relatively low minimal inhibitory concentrations (MICs) while doxycycline displayed a relatively higher value but was still considered to be effective. While imipenem was the most effective with low MIC values in vitro, sulphamethoxazole-trimethoprim had the highest i.e. least effective. Based on these results, the drugs commonly used in the treatment of leptospirosis (penicillin G, penicillin-streptomycin, doxycycline and ceftriaxone) in both humans and animals in Trinidad appear to have similar MICs and MBCs in vitro when compared with published reports. The serovar of Leptospira spp. and in most cases the origin of the isolates did not significantly (P>0.05) influence their susceptibilities to the antimicrobial agents tested.
authors: School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, Trinidad.
authors: S M
authors: SM
authors: Suepaul
authors: School of Medicine, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies.
authors: C
authors: C
authors: Carrington
authors: School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, Trinidad.
authors: M
authors: M
authors: Campbell
authors: School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, Trinidad.
authors: G
authors: G
authors: Borde
authors: School of Veterinary Medicine, Faculty of Medical Sciences, University of the West Indies, Trinidad.
authors: A A
authors: AA
authors: Adesiyun
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004283:Dog Diseases / Q000382:microbiology*; D004285:Dogs; D007919:Leptospira / Q000187:drug effects* / Q000302:isolation & purification*; D007922:Leptospirosis / Q000382:microbiology / Q000662:veterinary*; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D051381:Rats; D012376:Rodent Diseases / Q000382:microbiology*; D014300:Trinidad and Tobago
chemical_list: D000890:Anti-Infective Agents