title: Targeting dengue virus NS4B protein for drug discovery.
abstract: The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.
authors: Novartis Institute for Tropical Diseases, Singapore.
authors: Xuping
authors: X
authors: Xie
authors: Novartis Institute for Tropical Diseases, Singapore; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing, China.
authors: Jing
authors: J
authors: Zou
authors: Novartis Institute for Tropical Diseases, Singapore. Electronic address: qing_yin.wang@novartis.com.
authors: Qing-Yin
authors: QY
authors: Wang
authors: Novartis Institute for Tropical Diseases, Singapore. Electronic address: pei_yong.shi@novartis.com.
authors: Pei-Yong
authors: PY
authors: Shi
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003716:Dengue Virus / Q000187:drug effects* / Q000502:physiology; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004791:Enzyme Inhibitors; C080107:NS4B protein, flavivirus; D017361:Viral Nonstructural Proteins
keywords: Antivirals; Dengue; Flavivirus; NS4B; Nonstructural protein 4B