title: Prevention of peritoneal adhesion using a bacterial cellulose hydrogel, in experimental study.
abstract: OBJECTIVE
  To analyze the effectiveness of bacterial cellulose hydrogel as a barrier in preventing postoperative peritoneal adhesion in rat model.
  
  
  METHODS
  Experimental study with 45 Wistar rats (Rattus norvegicus) that were divided into three groups for the following treatments: A. Saline, B. Oxidized Regenerated Cellulose (ORC) barrier, and C Bacterial Cellulose Hydrogel (BCH) barrier. After 45 days of the surgery the adhesions were classified and graded according to the qualitative score. The histological parameters were evaluated using a modified semi-quantitative scale to rate the extent of fibrosis, inflammatory reaction and vascular proliferation.
  
  
  RESULTS
  Compared with the saline group (A), the treatments with ORC barrier (B) and BHC barrier (C) resulted in a smaller number of adhesions (p=0.019 and p=0.003 on Fisher's exact test, respectively). Data from inflammation and neovascularization showed no statistically significant difference between the groups BHC and ORC (p=0.426 and 0.446 on chi-square test, respectively).
  
  
  CONCLUSIONS
  Bacterial cellulose hydrogel is effective as a bio-re-absorbable barrier for preventing postoperative peritoneal adhesions.
authors: Federal University of Pernambuco, Recife, PE, Brazil.
authors: Elísio Rodrigues
authors: ER
authors: Coelho Junior
authors: College of Medical Sciences of Pernambuco, Department Maternal Child, State University of Pernambuco, Recife, PE, Brazil.
authors: Laura Olinda Bregieiro Fernandes
authors: LO
authors: Costa
authors: Faculty of Medical Sciences of Pernambuco, UPE, Recife, PE, Brazil.
authors: Arinaldo Vasconcelos
authors: AV
authors: Alencar
authors: Department of Gynecology and Obstetrics, Institute of Integrative Medicine Professor Fernando Figueira, Recife, PE, Brazil.
authors: Ana Paula Guimarães
authors: AP
authors: Barbosa
authors: Department of Surgery, Center for Health Sciences, UFPE, Recife, PE, Brazil.
authors: Flávia Crisina Morone
authors: FC
authors: Pinto
authors: Department of Surgery, UFPE, Recife, PE, Brazil.
authors: José Lamartine de Andrade
authors: JL
authors: Aguiar
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry*; D002482:Cellulose / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D010532:Peritoneal Diseases / Q000473:pathology / Q000517:prevention & control*; D010537:Peritoneum / Q000473:pathology; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D011897:Random Allocation; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013997:Time Factors; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control; D016896:Treatment Outcome; D014599:Uterus / Q000473:pathology / Q000601:surgery
chemical_list: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D002482:Cellulose