title: Histology of psoriatic erythroderma in infants: analytical study of eight cases.
abstract: BACKGROUND
  Erythroderma in infants is a rare condition of varied etiology. Psoriasis is now emerging as the most common cause of erythroderma in infants. Early diagnosis of the etiological cause much depends upon the histological confirmation, which is essential for an early and appropriate treatment.
  
  
  OBJECTIVE
  It was aimed to study the histological findings in psoriatic erythroderma in infants.
  
  
  METHODS
  A total of 8 infants up to 1 year of age presenting with erythroderma, clinically suspected to be of psoriatic etiology attending private clinic were included. After detailed history taking and astute clinical exam, all of them were biopsied. In case 6, with a positive family history of psoriasis and asthma in parents, biopsy was taken from two sites. The histological findings of all nine biopsies were studied and analyzed.
  
  
  RESULTS
  Histology of all eight children showed psoriasi form pattern with acanthosis (AC) and dilated papillary capillaries (PC). Spongiform (SF) pattern was seen in the second biopsy (6b) of child with features of both psoriasis and atopy. SF pustule of Kogoj or Munro's abscess was not seen in any of them.
  
  
  CONCLUSIONS
  Regular AC and PC dilatation were the consistent histological findings observed in infants with erythrodermic psoriasis. These were the early findings observed in younger infants. Co-existence of psoriasis with atopic dermatitis may indicate a common pathogenic mechanism or an immunogenetic spin-off.
authors: Department of Dermatology, Thanjavur Medical College, Thanjavur, India.
authors: Parimalam
authors: P
authors: Kumar
authors: Department of Skin and STD, Sree Balaji Medical College, Chennai, Tamil Nadu, India.
authors: Jayakar
authors: J
authors: Thomas
authors: Department of Dermatology, KK Child's Trust Hospital, Chennai, Tamil Nadu, India.
authors: Devaraj
authors: D
authors: Dineshkumar
keywords: Histology; infantile erythroderma; psoriasis