title: Novel antiphospholipid antibodies in autoimmune bullous diseases.
abstract: BACKGROUND
  Pemphigus and bullous pemphigoid are two autoimmune diseases that have similar pathogenesis. Both have a genetic predisposition, which promotes the production of auto antibodies targeted against different components of the epidermal desmosome and hemidesmosome. Antiphospholipid antibodies (aPL) are heterogeneous group of antibodies found in patients with autoimmune diseases and inflammatory conditions and are associated with thrombotic events.
  
  
  OBJECTIVE
  We sought to determine the expression profile of eight non classical aPLs in ABD patients.
  
  
  METHODS
  A cohort of 266 serum samples of patients with pemphigus, bullous pemphigoid and controls was screened for the presence of eight aPL antibodies, using the Bio-Rad BioPlex™ 2200 system.
  
  
  RESULTS
  Phosphatidylserine-beta-2-glycoprotein-I (aPS-β2GPI) and anti prothrombin complex (aPT-PT) serum profiles were significantly more prevalent among ABD patients; 20.7% patients with ABD compared to 5.9% of control patients were positive for aPS-β2GPI IgM. In addition, aPT-PT IgM was more prevalent among ABD patients (31% vs. 14.8%).
  
  
  CONCLUSIONS
  aPL auto antibodies are more prevalent in ABD. Any clinical association should be further determined.
authors: Department of Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel.
authors: Lior
authors: L
authors: Sagi
authors: Department of Dermatology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors: Sharon
authors: S
authors: Baum
authors: The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
authors: Ori
authors: O
authors: Barzilai
authors: The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
authors: Maya
authors: M
authors: Ram
authors: Laboratorio di Patologia Clinica, Ospedale Civile, Tolmezzo, Italy.
authors: Nicola
authors: N
authors: Bizzaro
authors: Fédération Autoimmunité et Thrombose, Laboratoire d'Immunologie Hôpital de La Conception, Marseille, France.
authors: Marielle
authors: M
authors: SanMarco
authors: The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors: Yehuda
authors: Y
authors: Shoenfeld
authors: The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel.
authors: Yaniv
authors: Y
authors: Sherer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D015551:Autoimmunity; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010392:Pemphigus / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D011516:Prothrombin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D053482:beta 2-Glycoprotein I / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology
chemical_list: D017152:Antibodies, Antiphospholipid; D007075:Immunoglobulin M; C097476:asialo-beta 2-glycoprotein I; D053482:beta 2-Glycoprotein I; D011516:Prothrombin
keywords: Autoimmunity; antiphospholipid antibodies; autoantibodies; bullous pemphigoid; pemphigus