title: Risk Factors for Age-Related Macular Degeneration in an Elderly Japanese Population: The Hatoyama Study.
abstract: OBJECTIVE
  To estimate the risk factors of AMD in an elderly Japanese population from a suburban area north of metropolitan Tokyo.
  
  
  METHODS
  The Hatoyama Cohort Study was launched in 2010, and 742 persons participated in the baseline study. Among these participants, 596 persons who attended the 2-year follow-up examinations in 2012 were evaluated, and the presence of early and late AMD was determined via grading of their fundus photographs. Based on the cohorts' data, logistic regression analyses were performed to identify the risk factors for AMD. The possible risk factors that we examined were age, sex, medical history of systemic disorders, smoking, inflammatory markers at baseline, and the complement factor H (CFH) I62V and age-related maculopathy susceptibility 2 (ARMS2) A69S variants.
  
  
  RESULTS
  We assessed 480 participants (40.0% women) who had gradable fundus photographs. The prevalence of early AMD was 37.9% and the prevalence of late AMD was 0.6%. Mantel-Haenszel analysis revealed that the CFH I62V and ARMS2 A69S variants were significantly associated with the prevalence of AMD (P = 0.029 and 0.025, respectively).
  
  
  CONCLUSIONS
  The CFH I62V and ARMS2 A69S variants were significantly associated with the prevalence of AMD. (www.umin.ac.jp/ctr number, UMIN000014520.).
authors: Department of Ophthalmology Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 2Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
authors: Aya
authors: A
authors: Aoki
authors: Department of Ophthalmology Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Xue
authors: X
authors: Tan
authors: Department of Ophthalmology Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Reiko
authors: R
authors: Yamagishi
authors: Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
authors: Shoji
authors: S
authors: Shinkai
authors: Department of Ophthalmology Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Ryo
authors: R
authors: Obata
authors: Department of Clinical Trial Data Management, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Tempei
authors: T
authors: Miyaji
authors: Department of Clinical Trial Data Management, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan 4Division of Biostatistics, Tohoku University Graduate School of Medicine, Miyagi, Japan.
authors: Takuhiro
authors: T
authors: Yamaguchi
authors: Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
authors: Jiro
authors: J
authors: Numaga
authors: Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
authors: Hideki
authors: H
authors: Ito
authors: Department of Ophthalmology Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors: Yasuo
authors: Y
authors: Yanagi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008268:Macular Degeneration / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D013997:Time Factors