title: Mitochondrial function and disturbances in the septic kidney.
abstract: Per milligram of tissue, only the heart exceeds the kidney's abundance of mitochondria. Not surprisingly, renal mitochondria are most densely concentrated in the epithelium of the nephron, at sites where the chemical work of moving solutes against electrochemical gradients places large and constant demands for adenosine triphosphate. Derangements of renal epithelial mitochondria appear to be a hallmark for diverse forms of acute kidney injury (AKI). The pathogenesis of multiple-organ dysfunction syndrome in sepsis is complex, but a substantial body of experimental and observational human data supports the twin concepts that mitochondrial dysfunction contributes to impaired filtration and that recovery of mitochondrial structure and function is essential for recovery from sepsis-associated AKI. These insights have suggested novel methods to diagnose, stratify, prevent, or even treat this common and deadly complication of critical illness. This review will do the following: (1) describe the structure and functions of healthy mitochondria and how renal energy metabolism relates to solute transport; (2) provide an overview of the evidence linking mitochondrial pathology to renal disease; (3) summarize the mitochondrial lesions observed in septic AKI; (4) analyze the role of mitochondrial processes including fission/fusion, mitophagy, and biogenesis in the development of septic AKI and recovery from this disease; and (5) explore the potential for therapeutically targeting mitochondria to prevent or treat septic AKI.
authors: Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Electronic address: sparikh1@bidmc.harvard.edu.
authors: Samir M
authors: SM
authors: Parikh
authors: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors: Yuan
authors: Y
authors: Yang
authors: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors: Liyu
authors: L
authors: He
authors: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors: Chengyuan
authors: C
authors: Tang
authors: Department of Pathology and Medicine, Northwestern University, Chicago, IL.
authors: Ming
authors: M
authors: Zhan
authors: Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Cellular Biology and Anatomy, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA.
authors: Zheng
authors: Z
authors: Dong
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism*; D004734:Energy Metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D063306:Mitophagy; D001678:Organelle Biogenesis; D018805:Sepsis / Q000150:complications / Q000378:metabolism*
keywords: Sepsis; kidney injury; mitochondria