title: Effect of clove and cinnamon extracts on experimental model of acute hematogenous pyelonephritis in albino rats: Immunopathological and antimicrobial study.
abstract: Recent studies showed prominent antimicrobial activity of some plant extracts on some pathogenic microorganisms so we evaluated antimicrobial activity of aqueous extracts of clove and cinnamon using the agar well diffusion method. An in vivo study was carried out on 40 adult healthy male albino rats divided into four groups: Group 1: negative control group (received intragastric saline solution daily); Group 2: injected with mixed bacterial suspension of S. aureus and E.coli as a model of pyelonephritis then received intragastric saline solution daily; Group 3: injected with the same dose of mixed bacterial suspension then received intragastric clove extract 500 mg/kg/day; and Group (4): injected with mixed bacterial suspension then received intragastric cinnamon 500 mg/kg/day. Five rats from each group were sacrificed after 1 and 4 weeks. Serum and blood samples were collected for lysozymes activity and nitric oxide production, lymphocyte transformation test, as well as counting of both total and differential leukocytes and erythrocytes. Kidney samples were tested histopathologically. Both in vivo and in vitro results confirmed the efficacy of clove extract as natural antimicrobials and suggested the possibility of its use in treatment of such bacterial infections.
authors: Medical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Ta'if, Saudi Arabia Pathology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt moh_nassan@yahoo.com.
authors: M A
authors: MA
authors: Nassan
authors: Medical Microbiology Department, Faculty of Applied Medical Sciences, Taif University, Ta'if, Saudi Arabia Bacteriology, Mycology and Immunology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
authors: E H
authors: EH
authors: Mohamed
authors: Medical Microbiology Department, Faculty of Applied Medical Sciences, Taif University, Ta'if, Saudi Arabia Immunobiology and Immunopharmacology Unit, Animal Reproduction Research Institute, Giza, Egypt.
authors: S
authors: S
authors: Abdelhafez
authors: Medical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Ta'if, Saudi Arabia Physiology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
authors: T A
authors: TA
authors: Ismail
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002935:Cinnamomum zeylanicum / Q000737:chemistry*; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000187:drug effects; D006402:Hematologic Diseases / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011704:Pyelonephritis / Q000188:drug therapy*; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects; D027842:Syzygium / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts
keywords: cinnamon; clove; extract; pyelonephritis