title: Histopathological findings in goiter: A review of 624 thyroidectomies.
abstract: OBJECTIVE
  To identify the histopathological patterns of goiter in thyroidectomy specimens and their frequency in relation to age and gender of the patients.
  
  
  METHODS
  We present a retrospective data of 624 thyroidectomy specimens diagnosed over a period of six year (2007-2012) at the Department of Pathology, Holy Family Hospital, Rawalpindi, Pakistan.
  
  
  RESULTS
  A total of 624 consecutive thyroidectomy specimens were selected. Patient's age ranges from 11-89 years, 541 females and 83 males. There were 512 (82%) non-neoplastic lesions, which includes; 475 (76.1%) multi-nodular goiter (MNG), 16 (2.6%) Hashimoto thyroiditis, 11 (1.8%) colloid goiter, 4 (0.6%) toxic goiter, 2 (0.3%) chronic lymphocytic thyroiditis, 2 (0.3%) tuberculous thyroiditis and 2 (0.3%) miscellaneous. From 112 (18%) neoplastic lesions, 43 (6.9%) were adenomas (41 females and 2 males) and 69 (11.0%) were carcinomas (58 females and 11 males). Peak age for thyroid malignancy was 3rd to 4th decades. The histological subtypes of thyroid carcinomas includes, 35 (5.6%) follicular variant of papillary carcinoma (FVPC), 15 (2.5%) well-differentiated tumor of uncertain malignant potential (WDT-UMP), 6 (1%) medullary carcinomas, 6 (1%) papillary carcinomas, 3 (0.5%) anaplastic carcinomas, 2 (0.3%) follicular carcinomas and 2 (0.3%) other carcinomas. Twenty-nine (4.6%) neoplastic lesions were associated with MNG, includes; 2 (3.5%) follicular adenomas, 3 (0.5%) WDT-UMP and 4 (0.6%) FVPC.
  
  
  CONCLUSIONS
  MNG is common and FVPC is the common thyroid cancer seen in females. The overall frequency of thyroid cancer is 11%. Follicular adenoma and FVPC appears to be associated with long standing MNG of iodine deficiency.
authors: Department of Pathology, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
authors: Imtiaz Ahmad
authors: IA
authors: Qureshi
authors: Department of Pathology, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
authors: Mohamad Nidal
authors: MN
authors: Khabaz
authors: Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
authors: Mukhtiar
authors: M
authors: Baig
authors: Department of Pathology, Holy Family Hospital, Rawalpindi, Pakistan.
authors: Bilquis
authors: B
authors: Begum
authors: Department of Pathology, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
authors: Amer Shafie
authors: AS
authors: Abdelrehaman
authors: Department of Microbiology, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
authors: Muhammad Barkaat
authors: MB
authors: Hussain
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015897:Comorbidity; D005260:Female; D006042:Goiter / Q000145:classification / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology; D013965:Thyroidectomy / Q000706:statistics & numerical data; D013966:Thyroiditis / Q000453:epidemiology* / Q000473:pathology; D055815:Young Adult
chemical_list: D007455:Iodine