title: Serum levels of hydroperoxides and multimorbidity among older patients with mild cognitive impairment or late-onset Alzheimer's disease.
abstract: BACKGROUND
  Oxidative stress (OxS) might be involved in the pathogenesis of late-onset Alzheimer disease (LOAD); noteworthy, the presence of multimorbidity is regarded as a common denominator of OxS and dementia.
  
  
  OBJECTIVE
  To evaluate the contribution of multimorbidity to OxS in LOAD and mild cognitive impairment (MCI).
  
  
  METHODS
  Serum hydroperoxides and multimorbidity (CIRS-CI scale) were evaluated in 46 Controls, 104 MCI and 75 LOAD.
  
  
  RESULTS
  A trend toward an increase of hydroperoxides from Controls to MCI to LOAD was observed (LOAD vs Controls p = 0.01). This OxS marker was positively and significantly correlated with CIRS-CI in Controls (p = 0.002) and patients with MCI (p = 0.005) but not in those with LOAD (p = 0.104).
  
  
  CONCLUSIONS
  Multimorbidity is associated with systemic OxS but only in elderly people with either no or mild cognitive impairment. Although OxS is elevated in LOAD patients, its association with multimorbidity seems to be negligible, confirming the existence of strong disease-specific pro-oxidant mechanisms.
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121, Ferrara, Italy.
authors: Carlo
authors: C
authors: Cervellati
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121, Ferrara, Italy.
authors: Arianna
authors: A
authors: Romani
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, 44100, Ferrara, Italy.
authors: Cristina
authors: C
authors: Bosi
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, 44100, Ferrara, Italy.
authors: Stefania
authors: S
authors: Magon
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, 44100, Ferrara, Italy.
authors: Angelina
authors: A
authors: Passaro
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121, Ferrara, Italy.
authors: Carlo M
authors: CM
authors: Bergamini
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, 44100, Ferrara, Italy. zlngnn@unife.it.|Section of Internal and CardioRespiratory Medicine, Department of Medical Sciences, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy. zlngnn@unife.it.
authors: Giovanni
authors: G
authors: Zuliani
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D015415:Biomarkers; D006861:Hydrogen Peroxide
keywords: Alzheimer’s disease; Hydroperoxides; Mild cognitive impairment; Multimorbidity; Oxidative stress