title: Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women.
abstract: OBJECTIVE
  To investigate the relationship between mid-gestational serum uric acid and birth weight in diabetic pregnant women with or without insulin resistance.
  
  
  METHODS
  In a prospective cohort study, fasting uric acid, blood glucose, and serum insulin were measured in 247 pregnant women between 20-22 weeks of gestational period. Insulin resistance was estimated using the homeostasis model assessment-insulin resistance (HOMA-IR). Stratification analysis and independent t-test was used to assess the association between uric acid and birth weights regarding to insulin resistance.
  
  
  RESULTS
  The means of the mid-gestational serum uric acid concentrations were not significantly different in women with and without insulin resistance. But stratification analysis showed that there was a significant difference between uric acid concentration and macrosomic birth in diabetic women without insulin resistance.
  
  
  CONCLUSIONS
  Higher mid - gestation serum uric acid concentration, even if it does not exceed the normal range, is accompanied by lower birth weight only in non-insulin resistance women. Insulin resistance could have a negative confounding effect on hyperuriemia and birth weight.
authors: Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran.
authors: Khadijeh
authors: K
authors: Nasri
authors: Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran.
authors: Maryamsadat
authors: M
authors: Razavi
authors: Department of Endocrinology, Arak University of Medical Sciences, Arak, Iran.
authors: Mohammad Reza
authors: MR
authors: Rezvanfar
authors: Department of Obstetrics and Gynecology, Arak University of Medical Sciences, Arak, Iran.
authors: Esmat
authors: E
authors: Mashhadi
authors: Thyroid Research Center, Arak University of Medical Sciences, Arak, Iran.
authors: Ali
authors: A
authors: Chehrei
authors: Department of Epidemiology and Biostatistics, Health Policy and Promotion Research Center, Qom University of Medical Sciences, Qom, Iran.
authors: Abolfazl
authors: A
authors: Mohammadbeigi
keywords: Metabolic syndrome; Second trimester; homeostasis model assessment-insulin resistance; hyperuricemia