title: Palladium(II)-catalyzed directed trifluoromethylthiolation of unactivated C(sp³)-H bonds.
abstract: The synthesis of trifluoromethylthiolated aliphatic acid derivatives by Pd-catalyzed C(sp(3))-H bond functionalization was developed. Using a bidentate directing group, the direct and selective introduction of a SCF3 moiety was possible on a range of amides with remarkable selectivity for C(sp(3))-centers with an electrophilic SCF3 source and pivalic acid as an additive. This work constitutes an example of the unactivated C(sp(3))-SCF3 bond formation by C-H activation offering a new access to relevant molecules.
authors: Normandie Université, COBRA, UMR 6014 et FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors: Heng-Ying
authors: HY
authors: Xiong
authors: Normandie Université, COBRA, UMR 6014 et FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors: Tatiana
authors: T
authors: Besset
authors: Normandie Université, COBRA, UMR 6014 et FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors: Dominique
authors: D
authors: Cahard
authors: Normandie Université, COBRA, UMR 6014 et FR 3038; Université de Rouen; INSA Rouen; CNRS, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors: Xavier
authors: X
authors: Pannecoucke