title: The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study.
abstract: Although a growing attention is being paid to acute ischemic stroke patients, the correlation between clinical outcome and infectious events in this population has been poorly investigated. 749 ischemic stroke (mean age 71 years old, males 56%) patients were enrolled in this prospective case-control study by 11 Italian Stroke Units. Demographic data, vascular risk factors, previous infections and post-stroke infections (PSIs) were recorded. Blood samples were collected and the enzyme-linked immunoassay was chosen to measure Chlamydia pneumoniae IgG and IgA plasma antibodies (antibody titers were classified with specific cut-off levels: IgA > 1:16 and IgG > 1:64). Early poor outcome was defined as mRS score >2 at discharge, while poor outcome at 6-month follow-up. Univariate and multivariate analyses were performed. Median NIHSS was 7, IgA and IgG antichlamydia pneumoniae seropositivities were observed in 308 (37.1%) and 207 (23.6%) patients, respectively. Multivariate analyses showed significant correlations between PSIs and NIHSS (RR: 1.06; 95% CI 1.02-1.09; p < 0.001) and PSIs and IgA antichlamydia pneumoniae seropositivity (RR: 3.84; 95% CI 2.53-5.84; p < 0.001). Significant disability was associated with baseline NIHSS (RR: 1.32; 95% CI 1.16-1.50; p < 0.001), IgA (RR: 2.67; 95% CI 1.06-6.70; p = 0.035) and IgG antichlamydia (RR: 5.75; 95% CI 1.83-18.03; p = 0.003) seropositivity and atrial fibrillation (RR: 2.58; 95% CI 1.81-3.67; p < 0.001). While previous infections were not associated with functional outcome, antichlamydia antibodies play a negative role in ischemic stroke patients. Preventive strategies may reduce the stroke burden and improve the clinical outcome.
authors: Department of Neurology, "G. Jazzolino" Hospital, Via P. Fleming, 89900, Vibo Valentia, Italy, neurologiavv@live.it.
authors: Domenico
authors: D
authors: Consoli
authors: Simone
authors: S
authors: Vidale
authors: Umberto
authors: U
authors: Aguglia
authors: Pietro
authors: P
authors: Bassi
authors: Anna
authors: A
authors: Cavallini
authors: Arturo
authors: A
authors: Consoli
authors: Franco
authors: F
authors: Galati
authors: Donata
authors: D
authors: Guidetti
authors: Giuseppe
authors: G
authors: Micieli
authors: Giuseppe
authors: G
authors: Neri
authors: Maurizia
authors: M
authors: Rasura
authors: Roberto
authors: R
authors: Sterzi
authors: Danilo
authors: D
authors: Toni
authors: Domenico
authors: D
authors: Inzitari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D002545:Brain Ischemia / Q000150:complications; D016022:Case-Control Studies; D002689:Chlamydia / Q000276:immunology / Q000472:pathogenicity*; D002690:Chlamydia Infections; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000209:etiology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial