title: Role of scavenger receptors in dendritic cell function.
abstract: Dendritic cells (DCs), the most potent of the antigen-presenting cells, are crucial in initiating and shaping innate and adaptive immune responses. DCs discriminate unmodified self antigens from non-self and altered/modified self antigens via a large family of receptors called pattern-recognition receptors, which include Toll-like receptors and scavenger receptors (SRs). Recent findings underscore the critical role of SRs on DCs in pathogen clearance, atherosclerosis, apoptotic cell recognition, diesel exhaust particle recognition, etc. These new findings present SRs as an unexplored therapeutic target that warrants further basic and applied research, and have implications for vaccine development. This review highlights recent insights into the emerging role of these receptors in DC-mediated immune responses.
authors: Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Dan
authors: D
authors: Wang
authors: Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China. Electronic address: sunboy4554@163.com.
authors: Bo
authors: B
authors: Sun
authors: Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Mei
authors: M
authors: Feng
authors: Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Hong
authors: H
authors: Feng
authors: Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Wuxian
authors: W
authors: Gong
authors: Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Qiang
authors: Q
authors: Liu
authors: Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, Jinan 250021, Shandong, PR China.
authors: Shujian
authors: S
authors: Ge
mesh_terms: D056704:Adaptive Immunity; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology*; D017209:Apoptosis; D002450:Cell Communication; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D052638:Particulate Matter / Q000737:chemistry / Q000276:immunology; D051116:Receptors, Scavenger / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000235:genetics* / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D000956:Antigens, Viral; D052638:Particulate Matter; D051116:Receptors, Scavenger; D051193:Toll-Like Receptors
keywords: Antigen-presenting cells; Dendritic cell; Scavenger receptors