title: Re-engineering islet cell transplantation.
abstract: We are living exciting times in the field of beta cell replacement therapies for the treatment of diabetes. While steady progress has been recorded thus far in clinical islet transplantation, novel approaches are needed to make cell-based therapies more reproducible and leading to long-lasting success. The multiple facets of diabetes impose the need for a transdisciplinary approach to attain this goal, by targeting immunity, promoting engraftment and sustained functional potency. We discuss herein the emerging technologies applied to this rapidly evolving field.
authors: Cell Transplant Center, Diabetes Research Institute, University of Miami, USA; University of Pisa, Italy.
authors: Nicoletta
authors: N
authors: Fotino
authors: Cell Transplant Center, Diabetes Research Institute, University of Miami, USA.
authors: Carmen
authors: C
authors: Fotino
authors: Cell Transplant Center, Diabetes Research Institute, University of Miami, USA; Departments of Surgery, Miller School of Medicine, University of Miami, USA; Departments of Microbiology and Immunology, Miller School of Medicine, University of Miami, USA; Department of Biomedical Engineering, University of Miami, USA. Electronic address: apileggi@miami.edu.
authors: Antonello
authors: A
authors: Pileggi
mesh_terms: D000818:Animals; D057005:Bioengineering; D003920:Diabetes Mellitus / Q000378:metabolism / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D006801:Humans; D056747:Immunomodulation; D016381:Islets of Langerhans Transplantation / Q000379:methods*
keywords: Beta cells; Biomaterials; Cellular therapies; Diabetes; Implantable devices; Insulin; Islet transplantation; Islets of Langerhans; Stem cells; Tissue engineering