title: Smartphone-based portable biosensing system using impedance measurement with printed electrodes for 2,4,6-trinitrotoluene (TNT) detection.
abstract: Rapid, sensitive, selective and portable detection of 2,4,6-trinitrotoluene (TNT) is in high demand for public safety and environmental monitoring. In this study, we reported a smartphone-based system using impedance monitoring for TNT detection. The screen-printed electrodes modified with TNT-specific peptides were used as disposable a biosensor to produce impedance responses to TNT. The responses could be monitored by a hand-held device and send out to smartphone through Bluetooth. Then, the smartphone was used to display TNT responses in real time and report concentration finally. In the measurement, the system was demonstrated to detect TNT at concentration as low as 10(-6) M and distinguish TNT versus different chemicals in high specificity. Thus, the smartphone-based biosensing platform provided a convenient and efficient approach to design portable instruments for chemical detections such as TNT recognition.
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China; Cyber Innovation Joint Research Center, Zhejiang University, Hangzhou 310027, PR China.
authors: Diming
authors: D
authors: Zhang
authors: Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, Illinois 61801, USA.
authors: Jing
authors: J
authors: Jiang
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Junye
authors: J
authors: Chen
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Qian
authors: Q
authors: Zhang
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Yanli
authors: Y
authors: Lu
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Yao
authors: Y
authors: Yao
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Shuang
authors: S
authors: Li
authors: Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, Illinois 61801, USA.
authors: Gang
authors: G
authors: Logan Liu
authors: Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China; Cyber Innovation Joint Research Center, Zhejiang University, Hangzhou 310027, PR China. Electronic address: qjliu@zju.edu.cn.
authors: Qingjun
authors: Q
authors: Liu
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004209:Disposable Equipment; D004566:Electrodes; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053834:Explosive Agents / Q000032:analysis; D008904:Miniaturization; D063731:Mobile Applications; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000068997:Smartphone; D014303:Trinitrotoluene / Q000032:analysis*; D014584:User-Computer Interface; D059015:Wireless Technology / Q000295:instrumentation
chemical_list: D053834:Explosive Agents; D014303:Trinitrotoluene
keywords: 2 4 6-trinitrotoluene (TNT); Impedance; Peptide; Portable instrument; Screen-printed electrode; Smartphone