title: Non-cell autonomous and non-catalytic activities of ATX in the developing brain.
abstract: The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Raanan
authors: R
authors: Greenman
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Anna
authors: A
authors: Gorelik
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Tamar
authors: T
authors: Sapir
authors: University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany ; Central Laboratory Animal Facility, University Medical Center, Johannes Gutenberg-University Mainz Mainz, Germany.
authors: Jan
authors: J
authors: Baumgart
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Vanessa
authors: V
authors: Zamor
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Michal
authors: M
authors: Segal-Salto
authors: Department of Chemical Research Support, Weizmann Institute of Science Rehovot, Israel.
authors: Smadar
authors: S
authors: Levin-Zaidman
authors: Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming' Athens, Greece.
authors: Vassilis
authors: V
authors: Aidinis
authors: Graduate School of Pharmaceutical Sciences, Tohoku University Miyagi, Japan.
authors: Junken
authors: J
authors: Aoki
authors: University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany.
authors: Robert
authors: R
authors: Nitsch
authors: University Medical Center, Institute for Microscopic Anatomy and Neurobiology, Johannes Gutenberg-University Mainz Mainz, Germany.
authors: Johannes
authors: J
authors: Vogt
authors: Department of Molecular Genetics, Weizmann Institute of Science Rehovot, Israel.
authors: Orly
authors: O
authors: Reiner
keywords: LPA; autotaxin; cortical development; in utero electroporation; neuronal stem cell; radial glia