title: The Role of 7,8-Dihydroxyflavone in Preventing Dendrite Degeneration in Cortex After Moderate Traumatic Brain Injury.
abstract: Our previous research showed that traumatic brain injury (TBI) induced by controlled cortical impact (CCI) not only causes massive cell death, but also results in extensive dendrite degeneration in those spared neurons in the cortex. Cell death and dendrite degeneration in the cortex may contribute to persistent cognitive, sensory, and motor dysfunction. There is still no approach available to prevent cells from death and dendrites from degeneration following TBI. When we treated the animals with a small molecule, 7,8-dihydroxyflavone (DHF) that mimics the function of brain-derived neurotrophic factor (BDNF) through provoking TrkB activation reduced dendrite swellings in the cortex. DHF treatment also prevented dendritic spine loss after TBI. Functional analysis showed that DHF improved rotarod performance on the third day after surgery. These results suggest that although DHF treatment did not significantly reduced neuron death, it prevented dendrites from degenerating and protected dendritic spines against TBI insult. Consequently, DHF can partially improve the behavior outcomes after TBI.
authors: Department of Histology and Embryology, Southern Medical University, Guangzhou, China.
authors: Shu
authors: S
authors: Zhao
authors: Spinal Cord and Brain Injury Research Group, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA.|Stark Neuroscience Research Institute, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA.|Department of Neurosurgery, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA.
authors: Xiang
authors: X
authors: Gao
authors: Department of Histology and Embryology, Southern Medical University, Guangzhou, China. wrdong@163.com.|, 1838 North Guangzhou Blvd, Guangzhou, 510515, China. wrdong@163.com.
authors: Weiren
authors: W
authors: Dong
authors: Spinal Cord and Brain Injury Research Group, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu.|Stark Neuroscience Research Institute, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu.|Department of Neurosurgery, Indiana University, 950 W. Walnut Street, Indianapolis, IN, 46202, USA. chen204@iupui.edu.|Indiana University, School of Medicine, 980 W. Walnut Street, R3, Indianapolis, IN, 46202, USA. chen204@iupui.edu.
authors: Jinhui
authors: J
authors: Chen
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000070642:Brain Injuries, Traumatic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000473:pathology*; D003712:Dendrites; D047309:Flavones / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: C485383:6,7-dihydroxyflavone; D047309:Flavones; D018696:Neuroprotective Agents
keywords: 7,8-Dihydroxyflavone; Brain-derived neurotrophic factor; Degeneration; Dendrite; Traumatic brain injury