title: Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway.
abstract: The present study was to determine the preventive effect of resveratrol (Res) on diabetes-induced cardiac dysfunction and the possible signaling pathway involved. Diabetes was induced in rats by injection of streptozotocin (STZ) at 45 mg/kg. The animals were randomly divided into three groups (10 rats/group): normal group, diabetes groups with or without Res (80 mg/kg) treatment. Biochemistry, cardiac function and fibrosis were detected. Moreover, pro-inflammatory cytokines were evaluated, and heart tissues were homogenized for western blot analysis to analyze the possible mechanisms. The results indicated that Res might regulate glucose and lipid metabolism, ameliorate cardiac function and fibrosis response in STZ-induced diabetic rats. The protective effects were consistent with the inhibition of inflammatory factors such as TNF-α, IL-6 and IL-1β. In addition, Res favorably shifted STZ-induced AT1R, ERK1/2 and p38 MAPK activation in rat heart. In conclusion, the results suggested that Res attenuated diabetes-induced cardiac dysfunction, and the effects were associated with attenuation inflammatory response and down-regulation of AT1R-ERK/p38 MAPK signaling pathway.
authors: School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
authors: Yonglin
authors: Y
authors: Gao
authors: School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
authors: Le
authors: L
authors: Kang
authors: School of Pharmacy, Yantai University, Yantai, 264005, Shandong, People's Republic of China. gaoyonglin@luye.cn.
authors: Chunmei
authors: C
authors: Li
authors: School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
authors: Xiaoyan
authors: X
authors: Wang
authors: School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
authors: Chengfeng
authors: C
authors: Sun
authors: School of Life Sciences, Yantai University, Yantai, 264005, Shandong, People's Republic of China.
authors: Qingzhong
authors: Q
authors: Li
authors: Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, People's Republic of China.
authors: Ruihua
authors: R
authors: Liu
authors: Yantai Yuhuangding Hospital, Yantai, 264000, Shandong, People's Republic of China. gylbill@163.com.
authors: Jianping
authors: J
authors: Wang
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D006331:Heart Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology / Q000627:therapeutic use*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D013267:Stilbenes; D048051:p38 Mitogen-Activated Protein Kinases; D000077185:Resveratrol
keywords: AT1R-ERK/p38 MAPK; Diabetes-induced cardiac dysfunction; Glucose and lipid metabolism; Inflammation response; Resveratrol