title: Structural chromosomal abnormalities in couples with recurrent abortion in Egypt.
abstract: OBJECTIVE
  To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis.
  
  
  METHODS
  The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis.
  
  
  RESULTS
  Among the 125 couples tested, 8 c6uples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed a reciprocal translocation and 1 (0.8%) showed a Robertsonian translocation. All carriers of these translocations were aged <35 years. A significant proportion of carriers reported a poor obstetric history and a past fetal malformation. All male carriers had a normal semen analysis.
  
  
  CONCLUSIONS
  Couples who experience ≥2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.
authors: Nagwa E A
authors: NE
authors: Gaboon
authors: Ahmed Ramy
authors: AR
authors: Mohamed
authors: Solaf M
authors: SM
authors: Elsayed
authors: Osama K
authors: OK
authors: Zaki
authors: Mohamed A
authors: MA
authors: Elsayed
mesh_terms: D059786:Abnormal Karyotype / Q000706:statistics & numerical data; D000026:Abortion, Habitual / Q000453:epidemiology* / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005313:Fetal Death; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult