title: Nasopharyngeal hyalinizing clear cell carcinoma with EWSR1 rearrangements diagnosed by fluorescence in situ hybridization.
abstract: Hyalinizing clear cell carcinoma (HCCC) is a rare, low-grade salivary gland neoplasm with a predilection for the palate and tongue. A 63-year-old woman presented a 14×14×17-mm mass at the roof of the nasopharynx. Endoscopic resection was performed via a transnasal approach. Histopathological findings of the salivary gland tumor indicated hyalinization of the stroma and neoplastic cells with clear cytoplasm without mucin. Fluorescence in situ hybridization analysis revealed that the tumor cells were positive for EWSR1 rearrangement. We finally diagnosed this case as HCCC of the nasopharynx. EWSR1 rearrangements are non-existent in other salivary gland tumors with clear cell change; thus, the identification of this rearrangement was very useful in accurately diagnosing HCCC.
authors: Department of Otolaryngology, Kushiro City General Hospital, 1-12, Syunkodai, Kushiro-shi, Hokkaido 085-0822, Japan. Electronic address: a.fukuda1019@gmail.com.
authors: Atsushi
authors: A
authors: Fukuda
authors: Department of Pathology, Sapporo Medical University School of Medicine, Minami 1, Nishi 17, Chuou-ku, Sapporo-shi, Hokkaido 060-8556, Japan.
authors: Yohei
authors: Y
authors: Tagami
authors: Department of Pathology, Sapporo Medical University School of Medicine, Minami 1, Nishi 17, Chuou-ku, Sapporo-shi, Hokkaido 060-8556, Japan.
authors: Akira
authors: A
authors: Takasawa
authors: Department of Surgical Pathology, Sapporo Medical University School of Medicine, Minami 1, Nishi 16, Chuou-ku, Sapporo-shi, Hokkaido 060-8543, Japan.
authors: Shintaro
authors: S
authors: Sugita
authors: Department of Otolaryngology, Kushiro City General Hospital, 1-12, Syunkodai, Kushiro-shi, Hokkaido 085-0822, Japan.
authors: Rinnosuke
authors: R
authors: Kuramoto
authors: Department of Otolaryngology, Kushiro City General Hospital, 1-12, Syunkodai, Kushiro-shi, Hokkaido 085-0822, Japan.
authors: Suguru
authors: S
authors: Imai
authors: Department of Surgical Pathology, Sapporo Medical University School of Medicine, Minami 1, Nishi 16, Chuou-ku, Sapporo-shi, Hokkaido 060-8543, Japan.
authors: Tadashi
authors: T
authors: Hasegawa
authors: Department of Otolaryngology, Kushiro City General Hospital, 1-12, Syunkodai, Kushiro-shi, Hokkaido 085-0822, Japan.
authors: Keiji
authors: K
authors: Iizuka
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics*; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics*
chemical_list: D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins
keywords: EWSR1 rearrangement; FISH; Hyalinizing clear cell carcinoma; Nasopharynx; Salivary gland tumor