title: Time to recanalisation in patients with cerebral venous thrombosis under anticoagulation therapy.
abstract: OBJECTIVE
  Few studies have investigated the rates of recanalisation after cerebral venous thrombosis (CVT). Our objective was to investigate the recanalisation rate and to identify predictors of recanalisation in patients with CVT.
  
  
  METHODS
  We included 102 patients with confirmed first-ever, non-septic CVT. All patients received anticoagulation for 12 months or until complete recanalisation. To assess recanalisation, patients underwent MR venography every 3 months until partial or complete recanalisation or for 12 months after diagnosis. We conducted two parallel analyses of complete recanalisation versus partial and no recanalisation versus any recanalisation. As a secondary objective we explored the influence of recanalisation on outcome and recurrent events. We calculated the probability of recanalisation using Kaplan-Meier analysis and conducted multivariate analysis using a Cox model.
  
  
  RESULTS
  The mean age of patients was 33.5±11 years (80 (78.4%) women). Survival analysis indicated that 50% of the patients had any recanalisation (grades I, II and III) by 64 days and complete recanalisation (grade III) by 169 days. Adjusted Cox proportional model revealed that age <50 years (HR=11.5 95% CI=1.58 to 84.46, p=0.01) and isolated superior sagittal sinus thrombosis (HR=0.39, 95% CI=0.14 to 1.04, p=0.05) predict complete recanalisation, while age <50 years (HR=4.79; 95% CI=1.69 to 13.5, p=0.003) predicts any recanalisation. Patients with complete recanalisation had a greater chance of good functional outcome (HR=5.17; 95% CI=2.8 to 9.53, p<0.001).
  
  
  CONCLUSIONS
  We found that recanalisation occurs over time, until month 11. Complete recanalisation may influence functional outcome.
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Antonio
authors: A
authors: Arauz
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Juan-Camilo
authors: JC
authors: Vargas-González
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Nayelli
authors: N
authors: Arguelles-Morales
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Miguel A
authors: MA
authors: Barboza
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Juan
authors: J
authors: Calleja
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Elizabeth
authors: E
authors: Martínez-Jurado
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Angélica
authors: A
authors: Ruiz-Franco
authors: Stroke Clinic, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico.
authors: Alejandro
authors: A
authors: Quiroz-Compean
authors: Neurology Department, Johns Hopkins Community Physicians, Bethesda, Maryland, USA.
authors: José G
authors: JG
authors: Merino
mesh_terms: D000328:Adult; D000367:Age Factors; D000925:Anticoagulants / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D010690:Phlebography / Q000187:drug effects*; D012189:Retrospective Studies; D013997:Time Factors; D020246:Venous Thrombosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000925:Anticoagulants
keywords: CEREBROVASCULAR DISEASE