title: Trichoharzianol, a new antifungal from Trichoderma harzianum F031.
abstract: A new decalin derivative, trichoharzianol (1), together with three known compounds, eujavanicol A (2), 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (3), and 4,6-dihydroxy-5-methylphthalide (4), were isolated from Trichoderma harzianum F031. For the first time, compounds 2-4 were reported from the Trichoderma species. Their structures were characterized by spectroscopic methods. Trichoharzianol (1) showed the highest antifungal activity against Colletotrichum gloeosporioides, with a minimum inhibitory concentration (MIC) of 128 μg/mL.
authors: Chotika
authors: C
authors: Jeerapong
authors: Worrapong
authors: W
authors: Phupong
authors: Phuwadol
authors: P
authors: Bangrak
authors: Warin
authors: W
authors: Intana
authors: §Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
authors: Patoomratana
authors: P
authors: Tuchinda
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D020231:Colletotrichum / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D014242:Trichoderma / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; C000603416:trichoharzianol
keywords: Colletotrichum gloeosporioides; Trichoderma harzianum; antifungal activity; chromone; decalin derivatives; phthalide