title: Investigation of an unusual increase in human yersinioses in Creuse, France.
abstract: OBJECTIVE
  To investigate an unusual cluster of Y. enterocolitica 4/O:3/VIII human infections that occurred in Creuse (France) during the summer 2008, and to perform retrospective and prospective analyses of yersiniosis cases to get a better view of the general trend.
  
  
  METHODS
  33 pathogenic Y. enterocolitica strains isolated between 2008 and 2010 in Creuse were subjected to phenotypic and molecular typing. The database of the Yersinia National Reference Laboratory was used to compare the number of human cases over 23 years in Creuse and at the national level.
  
  
  RESULTS
  The 33 isolates had three distinct phenotypes and a high genetic diversity, ruling out a unique source of contamination. A long-term analysis of yersiniosis cases in Creuse showed a progressive increase over years, with a peak in 2008 and a subsequent decrease. This trend contrasted with the national cases that showed an opposite pattern.
  
  
  CONCLUSIONS
  Local environmental conditions were most likely responsible for a transient expansion of pathogenic Y. enterocolitica strains in Creuse.
authors: Yersinia National Reference Laboratory, Institut Pasteur, Paris, France.
authors: Liliane
authors: L
authors: Martin
authors: Yersinia National Reference Laboratory, Institut Pasteur, Paris, France.
authors: Nicolas
authors: N
authors: Cabanel
authors: Laboratoires Associés Michaud/Lesoille, Aubusson, France.
authors: Christelle
authors: C
authors: Lesoille
authors: Laboratoire d'Analyses Médicales Biolyss, La Souterraine, France.
authors: Thierry
authors: T
authors: Ménard
authors: Yersinia National Reference Laboratory, Institut Pasteur, Paris, France. Electronic address: elisabeth.carniel@pasteur.fr.
authors: Elisabeth
authors: E
authors: Carniel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D014644:Genetic Variation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D015009:Yersinia Infections / Q000453:epidemiology*; D015008:Yersinia enterocolitica / Q000235:genetics / Q000302:isolation & purification*; D055815:Young Adult
keywords: MLVA; PFGE; Yersinia enterocolitica; diarrhoea; enteropathogen; epidemiology