title: A single quantum dot-based biosensor for telomerase assay.
abstract: Telomerase is a promising biomarker and a therapeutic target due to its extensive expression in human tumors such as lung cancer and breast cancer. Here, we develop a single quantum dot (QD)-based biosensor for the sensitive detection of telomerase activity. This single QD-based biosensor has significant advantages of simplicity and high sensitivity, and it can be applied for the discrimination of tumor cells from normal cells as well as the screening of anticancer drugs.
authors: Single-Molecule Detection and Imaging Laboratory, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. zhangcy@siat.ac.cn.
authors: Guichi
authors: G
authors: Zhu
authors: Kun
authors: K
authors: Yang
authors: Chun-Yang
authors: CY
authors: Zhang
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D002232:Carbocyanines / Q000737:chemistry; D045744:Cell Line, Tumor; D057075:Enzyme Assays / Q000379:methods*; D006801:Humans; D045663:Quantum Dots / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D019098:Telomerase / Q000378:metabolism*
chemical_list: D002232:Carbocyanines; C085321:cyanine dye 5; D019098:Telomerase