title: Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia.
abstract: According to the 2008 revision of the World Health Organization (WHO) classification of myeloid malignancies, philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPNs) include clonal, hematologic disorders such as polycythemia vera, primary myelofibrosis, and essential thrombocythemia.Recent years have witnessed major advances in the understanding of the molecular pathophysiology of these rare subgroups of chronic, myeloproliferative disorders. Identification of somatic mutations in genes associated with pathogenesis and evolution of these myeloproliferative conditions (Janus Kinase 2; myeloproliferative leukemia virus gene; calreticulin) led to substantial changes in the international guidelines for diagnosis and treatment of Ph-negative MPN during the last few years.The MPN-Working Group (MPN-WG), a panel of hematologists with expertise in MPN diagnosis and treatment from various parts of India, examined applicability of this latest clinical and scientific evidence in the context of hematology practice in India.This manuscript summarizes the consensus recommendations formulated by the MPN-WG that can be followed as a guideline for management of patients with Ph-negative MPN in the context of clinical practice in India.
authors: Department of Hematology, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.
authors: M B
authors: MB
authors: Agarwal
authors: Division of Medical Oncology, RK Birla Cancer Center, SMS Medical College Hospital, Jaipur, Rajasthan, India.
authors: Hemant
authors: H
authors: Malhotra
authors: Department of Hematology, NRS Medical College, Kolkata, West Bengal, India.
authors: Prantar
authors: P
authors: Chakrabarti
authors: Department of Hematology and Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Neelam
authors: N
authors: Varma
authors: Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India.
authors: Vikram
authors: V
authors: Mathews
authors: Department of Clinical Hematology, Guwahati Medical College and Hospital, Assam, India.
authors: Jina
authors: J
authors: Bhattacharyya
authors: Department of Hematology, All India Institute of Medical Sciences, Delhi Cantonment, India.
authors: Tulika
authors: T
authors: Seth
authors: Department of Hematopathology, Lifeline Tapadia Diagnostic Centre, Hyderabad, Telangana, India.
authors: K
authors: K
authors: Gayathri
authors: Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: Hari
authors: H
authors: Menon
authors: Department of Hematopathology Laboratory, Tata Memorial Hospital, Mumbai, Maharashtra, India.
authors: P G
authors: PG
authors: Subramanian
authors: Hematology and Center for Stem Cell Transplantation and Research, Army Research and Referral Hospital, Delhi Cantonment, India.
authors: Ajay
authors: A
authors: Sharma
authors: Institute of Hematology and Transfusion Medicine, Medical College, Kolkata, West Bengal, India.
authors: Maitreyee
authors: M
authors: Bhattacharyya
authors: Centre of Excellence in Histopathology, SRL Diagnostics, Mumbai, Maharashtra, India.
authors: Jay
authors: J
authors: Mehta
authors: Cancer Institute-Division of Medical Oncology and Haemotology, Medanta-The Medicity, New Delhi, India.
authors: A K
authors: AK
authors: Vaid
authors: Department of Medical Oncology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
authors: Sandeep
authors: S
authors: Shah
authors: Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India.
authors: Shyam
authors: S
authors: Aggarwal
authors: East India Hematological Centre, Rajgarh Road, Guwahati, Assam, India.
authors: P K
authors: PK
authors: Gogoi
authors: Department of Clinical Hematology, Tata Medical Centre, Kolkata, West Bengal, India.
authors: Reena
authors: R
authors: Nair
authors: Ashirwad Hematology Centre, Dadar, Mumbai, Maharashtra, India.
authors: Usha
authors: U
authors: Agarwal
authors: Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.
authors: Subhash
authors: S
authors: Varma
authors: Division of Medical Oncology, Apollo Cancer Hospitals, Hyderabad, Telangana, India.
authors: S V S S
authors: SV
authors: Prasad
authors: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Marie Therese
authors: MT
authors: Manipadam
keywords: Essential thrombocythemia; myeloproliferative neoplasms; polycythemia vera; primary myelofibrosis