title: Injury and repair in perinatal brain injury: Insights from non-invasive MR perfusion imaging.
abstract: Injury to the developing brain remains an important complication in critically ill newborns, placing them at risk for future neurodevelopment impairments. Abnormal brain perfusion is often a key mechanism underlying neonatal brain injury. A better understanding of how alternations in brain perfusion can affect normal brain development will permit the development of therapeutic strategies that prevent and/or minimize brain injury and improve the neurodevelopmental outcome of these high-risk newborns. Recently, non-invasive MR perfusion imaging of the brain has been successfully applied to the neonatal brain, which is known to be smaller and have lower brain perfusion compared to older children and adults. This article will present an overview of the potential role of non-invasive perfusion imaging by MRI to study maturation, injury, and repair in perinatal brain injury and demonstrate why this perfusion sequence is an important addition to current neonatal imaging protocols, which already include different sequences to assess the anatomy and metabolism of the neonatal brain.
authors: Department of Pediatrics, Montreal Children's Hospital, McGill University, 2300 rue Tupper, C-920, Montreal, Quebec, Canada H3H 1P3. Electronic address: pia.wintermark@bluemail.ch.
authors: Pia
authors: P
authors: Wintermark
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D018810:Magnetic Resonance Angiography; D055420:Perfusion Imaging; D010927:Placental Insufficiency / Q000175:diagnosis*; D011247:Pregnancy; D015203:Reproducibility of Results
keywords: Arterial spin labeling; Brain; Magnetic resonance imaging; Newborn; Perfusion