title: Transcriptional regulation of chemokine expression in ovarian cancer.
abstract: The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies.
authors: Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, New York, NY 11439, USA. bipradeb.singha10@my.stjohns.edu.
authors: Bipradeb
authors: B
authors: Singha
authors: Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, New York, NY 11439, USA. himavanthreddy.gatla12@my.stjohns.edu.
authors: Himavanth R
authors: HR
authors: Gatla
authors: Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, New York, NY 11439, USA. vancuroi@stjohns.edu.
authors: Ivana
authors: I
authors: Vancurova
mesh_terms: D001483:Base Sequence; D018925:Chemokines / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D014158:Transcription, Genetic
chemical_list: D018925:Chemokines