title: [Study of protective activivty of "Staphylovac-2" vaccine].
abstract: OBJECTIVE
  Study the protective properties of "Staphylovac-2" vaccinie.
  
  
  METHODS
  Samples of the vaccine manufactured by SPA "Microgen" based on the developed technology were studied in balb/c mice during 3- and 6-fold immunization schemes. Protective activity of the preparation was determined in experiments with active and passive protection during intraperitoneal infection, seeding of the causative agent from spleen and kidneys during intravenous infection, of animals.
  
  
  RESULTS
  In experiments with active protection of mice for both 3- and 6-fold immunization schemes, a significant protective activity of the studied series was determined, compared with the control group of mice. Sera obtained after animal immunization (rabbits, mice) by staphylococcus vaccine had protective properties. A reduction of spleen and kidneys seeding by Staphylococcus aureus in immunized mice compared with the control group was detected in the model of generalized staphylococci infection.
  
  
  CONCLUSIONS
  The preclinical studies carried out with the "Staphylovac-2" vaccine, developed baed on the complex of protective staplylococci antigens, have confirmed the high protective activity of the preparation.
authors: I M
authors: IM
authors: Gruber
authors: N B
authors: NB
authors: Egorova
authors: N A
authors: NA
authors: Mikhaĭlova
authors: L S
authors: LS
authors: Cherkasova
authors: O E
authors: OE
authors: Tarasova
authors: E A
authors: EA
authors: Astashkina
authors: O M
authors: OM
authors: Ignatova
authors: E A
authors: EA
authors: Kurbatova
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D058491:Bacterial Load; D007106:Immune Sera / Q000008:administration & dosage*; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011817:Rabbits; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D013211:Staphylococcus aureus / Q000737:chemistry / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D007106:Immune Sera; D013209:Staphylococcal Vaccines