title: Clinical characteristics of pregnancies with a history of recurrent miscarriage at a Japanese perinatal center.
abstract: OBJECTIVE
  We examined obstetric and fetal/neonatal outcomes in women with a history of recurrent miscarriage.
  
  
  METHODS
  We reviewed the obstetric records of all 5,829 nulliparous pregnant women who delivered at #8805;14 weeks' gestation from 2008 through 2013 at our perinatal center. Of these women, 74 had a history of recurrent miscarriage (1.3%). The control population consisted of 4,176 nulliparous women without a history of miscarriage. Demographic information and characteristics of labor were extracted from patient charts.
  
  
  RESULTS
  The rate of maternal age #8805;40 years (p<0.01) and the rate of in vitro fertilization use (p<0.01) were higher in women with recurrent miscarriage than in women without miscarriage. Eleven women with recurrent miscarriage (14.9%) were treated with low-dose aspirin with and without subcutaneous heparin. In addition, the rate of cesarean delivery was higher in women with recurrent miscarriage than in women without miscarriage (p=0.02). However, fetal/neonatal outcomes did not differ significantly between the populations.
  
  
  CONCLUSIONS
  The pregnancy of women with a history of recurrent miscarriage is not associated with adverse outcomes at our perinatal center.
authors: Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital.
authors: Kayoko
authors: K
authors: Terada
authors: Kazuho
authors: K
authors: Nakanishi
authors: Shunji
authors: S
authors: Suzuki
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D005307:Fertilization in Vitro; D005313:Fetal Death; D005865:Gestational Age; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007564:Japan; D050498:Live Birth; D008423:Maternal Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D006493:Heparin; D001241:Aspirin