title: Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.
abstract: Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India.
authors: S S
authors: SS
authors: Nair
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India.
authors: J J
authors: JJ
authors: Manalil
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India.
authors: S K
authors: SK
authors: Ramavarma
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India.
authors: I M
authors: IM
authors: Suseela
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India.
authors: A
authors: A
authors: Thekkepatt
authors: Department of Biochemistry, Amala Cancer Research Centre, University of Calicut, Amala Nagar, Thrissur, Kerala, India achuthanm@gmail.com.
authors: A C
authors: AC
authors: Raghavamenon
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001806:Blood Urea Nitrogen; D000074263:Coconut Oil; D003404:Creatinine / Q000378:metabolism; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D019587:Dietary Supplements; D004487:Edema / Q000473:pathology / Q000517:prevention & control; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010938:Plant Oils / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000477:Alkylating Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; D005557:Formaldehyde; D003520:Cyclophosphamide; D003404:Creatinine; D000074263:Coconut Oil
keywords: Antioxidant enzyme; VCO; chemotherapy; cytoprotection; lipid peroxidation