title: The Signature Program: Bringing the Protocol to the Patient.
abstract: Early-phase clinical development in oncology has evolved dramatically with the deciphering of the human genome in 2004. Genomic analysis and the tools identifying genetically disrupted pathways within a patient's tumor have been a driving force for personalized medicine and for the development of highly targeted novel therapies. Tumors are often genetically heterogeneous, with multiple concurrent genetic abnormalities. On the other hand, tumors arising from different tissues may share identical molecular drivers.
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: B P
authors: BP
authors: Kang
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: E
authors: E
authors: Slosberg
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: S
authors: S
authors: Snodgrass
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: C
authors: C
authors: Lebedinsky
authors: MD Anderson Cancer Center, Houston, Texas and Berry Consultants, Austin, Texas, USA.
authors: D A
authors: DA
authors: Berry
authors: Oregon Health & Science University, Portland, Oregon, USA.
authors: C L
authors: CL
authors: Corless
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: S
authors: S
authors: Stein
authors: Novartis Pharmaceuticals, East Hanover, New Jersey, USA.
authors: A
authors: A
authors: Salvado
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000235:genetics*; D019091:Critical Pathways; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008495:Medical Oncology / Q000379:methods*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D018579:Patient Selection; D010641:Phenotype; D057285:Precision Medicine; D011237:Predictive Value of Tests; D011379:Prognosis; D016730:Program Development; D012107:Research Design
chemical_list: D014408:Biomarkers, Tumor