title: Deproteinized Bovine Bone Mineral or Autologous Bone at Dehiscence Type Defects at Implants Installed Immediately into Extraction Sockets: An Experimental Study in Dogs.
abstract: OBJECTIVE
  The aim of this study was to evaluate bone regeneration at surgically created dehiscence buccal defects at implants placed immediately into extraction sockets (IPIES) of small dimensions filled with autogenous bone or deproteinized bovine bone mineral (DBBM) associated with a collagen membrane.
  
  
  METHODS
  Eight Labrador dogs were used and implants were placed immediately into the extraction sockets of the second premolar. The buccal wall was subsequently removed to create a standardized defect, 4 mm wide coronally, 2 mm wide apically, and 6 mm high. Autogenous bone particles (AB) or DBBM granules were used to fill the defects. All surgical sites were subsequently covered by a resorbable collagen membrane and a non-submerged healing was allowed. After 4 months, the animals were euthanized and bone blocks harvested and processed for histomorphometric analysis.
  
  
  RESULTS
  The bony crest at the buccal aspect (C) was located 2.3 ± 0.8 mm and 1.7 ± 0.7 mm apically to the implant shoulder (IS) at the AB and DBBM sites, respectively. The coronal levels of osseointegration at the buccal aspect (B) were located 2.7 ± 0.7 mm and 2.2 ± 1.0 mm apically to IS at the AB and DBBM sites, respectively. At the AB sites, the peri-implant mucosa was located 4.3 ± 0.9 mm, 4.7 ± 0.9 mm, and 2.0 ± 1.6 mm coronally to C, B, and IS, respectively. The corresponding values at the DBBM sites were 4.3 ± 0.6 mm, 4.8 ± 0.6 mm, and 2.5 ± 0.8 mm, respectively. No statistically significant differences were found.
  
  
  CONCLUSIONS
  The treatment of surgically created buccal defects at IPIES sites using Bio-Oss® (Geistlich Biomaterials, Wolhusen, LU, Switzerland) or autogenous bone, concomitantly with a collagen membrane, engenders bone regeneration to a similar extent after 4 months of healing.
authors: Fundação Municipal de Educação e Cultura (FUNEC), Faculty of Dentistry of Araçatuba, UNESP - Universidade Estadual Paulista, Aracatuba, São Paulo, Brazil.
authors: Flavia Priscila
authors: FP
authors: Pereira
authors: Roseto degli Abruzzi (TE), ARDEC, Ariminum Odontologica, Rimini, Italy.
authors: Enzo
authors: E
authors: De Santis
authors: Fundação Municipal de Educação e Cultura (FUNEC), Faculty of Dentistry of Araçatuba, UNESP - Universidade Estadual Paulista, Aracatuba, São Paulo, Brazil.
authors: Eduardo
authors: E
authors: Hochuli-Vieira
authors: Fundação Municipal de Educação e Cultura (FUNEC), Faculty of Dentistry of Araçatuba, UNESP - Universidade Estadual Paulista, Aracatuba, São Paulo, Brazil.
authors: Eduardo F
authors: EF
authors: de Souza Faco
authors: Roseto degli Abruzzi (TE), Italy, San Marino Republic, San Marino.
authors: Fabio
authors: F
authors: Pantani
authors: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirao Preto, São Paulo, Brazil.
authors: Luiz A
authors: LA
authors: Salata
authors: Ariminum Odontologica, Faculty of Dentistry, University of Medical Science, La Habana, Cuba.
authors: Daniele
authors: D
authors: Botticelli
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D002417:Cattle; D003094:Collagen; D015921:Dental Implants; D004285:Dogs; D057893:Immediate Dental Implant Loading; D023421:Models, Animal; D009061:Mouth Mucosa / Q000502:physiology / Q000601:surgery; D020390:Tooth Socket / Q000502:physiology* / Q000601:surgery; D014182:Transplantation, Autologous
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D003094:Collagen
keywords: DBBM; animal study; autologous bone; bone healing; collagen membrane; extraction socket; implant dentistry; osseointegration; regeneration; ridge preservation