title: Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.
abstract: BACKGROUND
  Urinary Schistosomiasis is a neglected tropical disease endemic in many sub Saharan -African countries. Collectin Kidney 1 (CL-K1, encoded by COLEC11 on chromosome 2p25.3), a member of the vertebrate C-type lectin super family, has recently been identified as pattern-recognition molecule (PRR) of the lectin complement pathway. CL-K1 is preferentially expressed in the kidneys, but also in other organs and it is considered to play a role in host defense to some infectious agents. Schistosome teguments are fucosylated and CL-K1 has, through its collagen-like domain, a high binding affinity to fucose.
  
  
  RESULTS
  We utilized a Nigerian study group consisting of 167 Schistosoma haematobium infected individuals and 186 matched healthy subjects, and investigated the contribution of CL-K1 deficiency and of COLEC11 polymorphisms to infection phenotype. Higher CL-K1 serum levels were associated with decreased risk of schistosome infection (P corr = 0.0004). CL-K1 serum levels were differentially distributed between the COLEC11 genotypes and haplotypes observed. The non-synonymous variant p.R216H was associated with the occurrence of schistosomiasis (OR = 0.44, 95%CI = 0.22-0.72, P corr = 0.0004). The reconstructed COLEC11*TCCA haplotypes were associated with higher CL-K1 serum levels (P = 0.002) and with decreased schistosomiasis (OR = 0.38, 95%CI = 0.23-0.63, P corr = 0.0001).
  
  
  CONCLUSIONS
  In agreement with findings from our earlier published study, our findings support the observation that CL-K1 and their functional variants may be host factors associated with protection in schistosomiasis and may be a useful marker for further investigations.
authors: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors: Justin S
authors: JS
authors: Antony
authors: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
authors: Olusola
authors: O
authors: Ojurongbe
authors: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors: Peter G
authors: PG
authors: Kremsner
authors: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Fondation Congolaise pour la Recherche Medicale, Brazzaville, Republic of Congo.
authors: Thirumalaisamy P
authors: TP
authors: Velavan
mesh_terms: D015415:Biomarkers / Q000097:blood; D037222:Collectins / Q000097:blood / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D037582:Complement Pathway, Mannose-Binding Lectin / Q000502:physiology*; D004198:Disease Susceptibility / Q000097:blood / Q000378:metabolism*; D005643:Fucose / Q000378:metabolism; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D058069:Neglected Diseases; D009549:Nigeria; D016017:Odds Ratio; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D012553:Schistosomiasis haematobia / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C518521:Colec11 protein, human; D037222:Collectins; D051192:Receptors, Pattern Recognition; D005643:Fucose