title: Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: a split-mouth, double-blind, self-controlled, clinical trial.
abstract: We investigated the effect of antibiotic prophylaxis on postoperative inflammatory complications after operations for impacted mandibular third molars in Chinese patients. A total of 207 patients had their bilateral third molars removed in a split-mouth, double-blind, self-controlled, clinical trial in two visits. For one side amoxicillin (or clindamycin) was given (antibiotic group) from one hour before operation until 3 days postoperatively. For the other side a placebo was given (placebo group) at the same time. The outcome, including alveolar osteitis, surgical wound infection, prebuccal infection, and infection of the anterior isthmus of fauces, was assessed 2 and 10 days postoperatively. A total of 192 patients completed the study, and there was no difference between the groups in the incidence of inflammatory complications. In the treatment group, there were 4 cases of alveolar osteitis (2%), 2 infections of the wound (1%), and 14 other reactions (gastrointestinal (n=4), bleeding (n=2), ulcer (n=2), and fever (n=6)). In the placebo group, there were 6 cases of alveolar osteitis (3%), 2 wound infections (1%), and 22 other reactions (bleeding (n=6), ulcer (n=2) and fever (n=14)). There was no significant difference in the extraction time and postoperative reactions, except the pain score on day 10 (p=0.005). Prophylactic amoxicillin (or clindamycin) is not effective for the prevention or reduction of postoperative inflammatory complications after the removal of impacted mandibular third molars in Chinese patients.
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China.
authors: P
authors: P
authors: Xue
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China.
authors: J
authors: J
authors: Wang
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China.
authors: B
authors: B
authors: Wu
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China.
authors: Y
authors: Y
authors: Ma
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China.
authors: F
authors: F
authors: Wu
authors: State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University, Xi'an 710032, China. Electronic address: denthr@sina.com.
authors: R
authors: R
authors: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D002981:Clindamycin / Q000627:therapeutic use; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004368:Dry Socket / Q000517:prevention & control*; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D061646:Operative Time; D006472:Oral Hemorrhage / Q000209:etiology; D019226:Oral Ulcer / Q000209:etiology; D010027:Osteotomy / Q000379:methods; D010149:Postoperative Pain / Q000209:etiology; D010919:Placebos; D019106:Postoperative Hemorrhage / Q000209:etiology; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014095:Tooth, Impacted / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D002981:Clindamycin; D000658:Amoxicillin
keywords: Antibiotic treatment ;; Impacted mandibular third molar surgery; Inflammatory complications