title: Inhibition of insulin-like growth factor receptor: end of a targeted therapy?
abstract: The Insulin-like Growth Factor 1 (IGF-1) signaling pathway activates several downstream signals important to lung cancer development and survival. IGF-1R activation has been linked to cancer risk in epidemiological studies and tumorigenesis in preclinical models. Several inhibitors of the insulin-like growth factor 1 receptor (IGF-1R) have been tested in clinical trials. Despite promising data in early phase studies, most studies of IGF-1R antagonists in combination with chemotherapy or with epidermal growth factor receptor (EGFR) inhibitors in non-small cell lung cancer (NSCLC) yielded disappointing results. Biomarker studies of clinical trials have identified IGF-1 levels as a potential marker of sensitivity to IGF-1R inhibition. Further study will need to focus on selection of NSCLC patients most likely to benefit from the addition of IGF-1R antagonists to standard therapy and the development of rational strategies for combination therapy in NSCLC.
authors: Winship Cancer Institute, Emory University, GA, USA.
authors: Rathi N
authors: RN
authors: Pillai
authors: Winship Cancer Institute, Emory University, GA, USA.
authors: Suresh S
authors: SS
authors: Ramalingam
keywords: Insulin-like Growth Factor 1 (IGF-1); epidermal growth factor receptor (EGFR); insulin-like growth factor 1 receptor (IGF-1R); non-small cell lung cancer (NSCLC)