title: Serous tubal intraepithelial carcinoma: an incidental finding at the time of prophylactic bilateral salpingo-oophorectomy.
abstract: Background. Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion for high-grade pelvic serous carcinoma. The incidence of STIC is estimated to occur in 0.6% to 6% of women who are BRCA positive or have a strong family history of breast or ovarian cancer. Case. A 56-year-old woman underwent robotic-assisted sacrocolpopexy, rectocele repair, and concurrent bilateral salpingo-oophorectomy for recurrent stage 3 pelvic organ prolapse and reported family history of ovarian cancer. Histopathologic examination of her left fallopian tube revealed STIC. Conclusion. We report this rare occurrence of STIC in a patient undergoing surgery primarily for pelvic organ prolapse and having a family history of ovarian cancer. Possible management options include observation with annual physical exam and CA-125, surgical staging, or empiric chemotherapy. However, due to the lack of consensus regarding management options, referral to a gynecologic oncologist is recommended.
authors: Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.
authors: Monique Hiersoux
authors: MH
authors: Vaughan
authors: Thornton Gynecologic Oncology Division, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.
authors: Susan C
authors: SC
authors: Modesitt
authors: Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
authors: Yunchuan
authors: Y
authors: Mo
authors: Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Virginia Health System, Charlottesville, VA, USA.
authors: Elisa R
authors: ER
authors: Trowbridge