title: Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp.
abstract: Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 μM) and a panel of human cancer cell lines (IC50 > 7.5 μM). Significantly, 1-4 were cytotoxic (IC50 0.7-1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin.
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Zeinab G
authors: ZG
authors: Khalil
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Ritesh
authors: R
authors: Raju
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Andrew M
authors: AM
authors: Piggott
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Angela A
authors: AA
authors: Salim
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Antje
authors: A
authors: Blumenthal
authors: †Institute for Molecular Bioscience, ⊥Diamantina Institute, and ∥Australian Infectious Diseases Research Centre, The University of Queensland, St Lucia, QLD 4072, Australia.
authors: Robert J
authors: RJ
authors: Capon
mesh_terms: D018943:Anthracyclines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D001412:Bacillus subtilis / Q000187:drug effects; D001483:Base Sequence; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009163:Mycobacterium bovis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C000600879:aranciamycin I; C000600880:aranciamycin J; C075925:aranciamycin