title: Metabolism of classical cannabinoids and the synthetic cannabinoid JWH-018.
abstract: Although the putative pharmacological targets of synthetic cannabinoids (SCBs) abused in "K2" and "Spice" are similar to Δ(9) -tetrahydrocannabinol (Δ(9) -THC), it remains unclear why SCB toxicity is similar yet different from marijuana. There are obvious potency and efficacy differences, but also important metabolic differences that help explain the unique adverse reactions associated with SCBs. This brief review discusses the limited research on the metabolism of the SCB JWH-018 and contrasts that with the metabolism of Δ(9) -THC.
authors: Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, New York, USA.
authors: M K
authors: MK
authors: Su
authors: Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas, USA.
authors: K A
authors: KA
authors: Seely
authors: Arkansas Department of Health, Public Health Laboratory, Little Rock, Arkansas, USA.|Department of Pharmacology & Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors: J H
authors: JH
authors: Moran
authors: Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, New York, USA.
authors: R S
authors: RS
authors: Hoffman
mesh_terms: D002186:Cannabinoids / Q000378:metabolism*; D019389:Cytochrome P-450 CYP2D6 / Q000502:physiology; D013759:Dronabinol / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000378:metabolism*; D009281:Naphthalenes / Q000378:metabolism*; D043884:Receptor, Cannabinoid, CB1 / Q000187:drug effects
chemical_list: D002186:Cannabinoids; D007211:Indoles; D009281:Naphthalenes; D043884:Receptor, Cannabinoid, CB1; D013759:Dronabinol; D019389:Cytochrome P-450 CYP2D6; C122075:UDP-glucuronosyltransferase, UGT1A3; D014453:Glucuronosyltransferase; C552597:1-pentyl-3-(1-naphthoyl)indole