title: Postpartum depression: A systematic review of the genetics involved.
abstract: Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression (PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression (MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases PubMed, LILACS and SciELO using the index terms "postpartum depression" and "genetics". Literature searches for articles in peer-reviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD.
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Tiago Castro E
authors: TC
authors: Couto
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Mayra Yara Martins
authors: MY
authors: Brancaglion
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: António
authors: A
authors: Alvim-Soares
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Lafaiete
authors: L
authors: Moreira
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Frederico Duarte
authors: FD
authors: Garcia
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Rodrigo
authors: R
authors: Nicolato
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Regina Amélia Lopes P
authors: RA
authors: Aguiar
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Henrique Vitor
authors: HV
authors: Leite
authors: Tiago Castro e Couto, Mayra Yara Martins Brancaglion, António Alvim-Soares, Lafaiete Moreira, Frederico Duarte Garcia, Rodrigo Nicolato, Humberto Corrêa, Postgraduate Program in Molecular Medicine, School of Medicine, Universidade Federal de Minas Gerais ,Belo Horizonte 30130100, MG, Brazil.
authors: Humberto
authors: H
authors: Corrêa
keywords: Genes; Genetics; Molecular; Postpartum depression; Single nucleotide polymorphisms