title: [Assessment of motor and sensory pathways of the brain using diffusion-tensor tractography in children with cerebral palsy].
abstract: BACKGROUND
  Diffusion tensor tractography--a new method of magnetic resonance imaging, that allows to visualize the pathways of the brain and to study their structural-functional state.
  
  
  OBJECTIVE
  The authors investigated the changes in motor and sensory pathways of brain in children with cerebral palsy using routine magnetic resonance imaging and diffusion-tensor tractography.
  
  
  METHODS
  The main group consisted of 26 patients with various forms of cerebral palsy and the comparison group was 25 people with normal psychomotor development (aged 2 to 6 years) and MR-picture of the brain. Magnetic resonance imaging was performed on the scanner with the induction of a magnetic field of 1,5 Tesla. Coefficients of fractional anisotropy and average diffusion coefficient estimated in regions of the brain containing the motor and sensory pathways: precentral gyrus, posterior limb of the internal capsule, thalamus, posterior thalamic radiation and corpus callosum.
  
  
  RESULTS
  Statistically significant differences (p < 0.05) values of fractional anisotropy and average diffusion coefficient in patients with cerebral palsy in relation to the comparison group. All investigated regions, the coefficients of fractional anisotropy in children with cerebral palsy were significantly lower, and the average diffusion coefficient, respectively, higher.
  
  
  CONCLUSIONS
  These changes indicate a lower degree of ordering of the white matter tracts associated with damage and subsequent development of gliosis of varying severity in children with cerebral palsy. It is shown that microstructural damage localized in both motor and sensory tracts that plays a leading role in the development of the clinical picture of cerebral palsy.
authors: A M
authors: AM
authors: Memedyarov
authors: L S
authors: LS
authors: Namazova-Baranova
authors: Y V
authors: YV
authors: Ermolina
authors: A V
authors: AV
authors: Anikin
authors: O I
authors: OI
authors: Maslova
authors: M Z
authors: MZ
authors: Karkashadze
authors: O A
authors: OA
authors: Klochkova
mesh_terms: D016880:Anisotropy; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging; D005260:Female; D005911:Gliosis / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values