title: Complications of serogroup B meningococcal disease in survivors: a review.
abstract: This systematic review evaluates the prevalence of long-term complications of serogroup B meningococcal disease (MD) in light of the recent licensure of a vaccine against meningococcal B disease. Twelve appropriate studies were identified by searching available databases from 1946 to July 2014. The average prevalence of hearing impairment was 4.2% among serogroup B MD survivors; 2.3% suffered amputation and 2.3% developed seizures. When compared with complications due to non-meningococcal B bacterial meningitis, physical impairment and seizures were more common in survivors of meningococcal B disease but hearing impairment had similar prevalence. Few studies quantified less frequent complications such as visual impairment and cognitive dysfunction. Better comprehensive reporting of the complications and costs of serogroup B MD in survivors and their families is needed to inform vaccination policy.
authors: Fereshteh
authors: F
authors: Dastouri
authors: Ahmad Mirmohammad
authors: AM
authors: Hosseini
authors: Elizabeth
authors: E
authors: Haworth
authors: Gulam
authors: G
authors: Khandaker
authors: Harunor
authors: H
authors: Rashid
authors: National Centre for Immunisation Research and Surveillance, Kids Research Institute, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. fereshteh.dastouri@health.nsw.gov.au.
authors: Robert
authors: R
authors: Booy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008585:Meningitis, Meningococcal / Q000150:complications*; D008589:Meningococcal Infections / Q000150:complications*; D022401:Meningococcal Vaccines; D008875:Middle Aged; D038541:Neisseria meningitidis, Serogroup B; D015995:Prevalence; D017741:Survivors / Q000706:statistics & numerical data; D014611:Vaccination; D055815:Young Adult
chemical_list: D022401:Meningococcal Vaccines