title: Genetic and environmental effects on the bone development of the hand and wrist in Chinese young twins.
abstract: We assessed genetic and environmental effects on bone development of the hand and wrist, and on key anthropometric measures in Chinese young twins. In total, 139 monozygotic and 95 dizygotic twin pairs aged from 5 to 18 years were recruited. The twin correlations of total hand and wrist scores for monozygotic (MZ) and dizygotic (DZ) twins were 0.71 and 0.36, respectively. Bivariate model analysis showed moderate genetic correlations only for total skeletal maturity vs. weight and total skeletal maturity vs. waist circumference (r, 0.51 and 0.46, respectively). Our findings demonstrated that genetic factors played important roles in bone development of the hand and wrist in Chinese young twins, and that these genetic effects might be distinct from those influencing anthropometric measures.
authors: School of Public Health, Shandong University, Jinan 250012, Shandong, China; Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Li Yan
authors: LY
authors: Dong
authors: School of Public Health, Jilin University, Changchun 130021, Jilin, China; Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors: Ji Bin
authors: JB
authors: Tan
authors: Qingdao Center Medical Group, Qingdao 266033, Shandong, China.
authors: Jing Lan
authors: JL
authors: Zhao
authors: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Fa Chun
authors: FC
authors: Jiang
authors: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Xiao Cao
authors: XC
authors: Tian
authors: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Feng
authors: F
authors: Ning
authors: Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Shao Jie
authors: SJ
authors: Wang
authors: Department of Epidemiology and Health Statistics, Medical College, Qingdao University, Qingdao 266021, Shandong, China.
authors: Dong Feng
authors: DF
authors: Zhang
authors: School of Public Health, Shandong University, Jinan 250012, Shandong, China; Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
authors: Zeng Chang
authors: ZC
authors: Pang
authors: School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors: Zhong Tang
authors: ZT
authors: Zhao
mesh_terms: D000293:Adolescent; D001846:Bone Development / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002681:China; D004781:Environmental Exposure; D050276:Hand Bones / Q000254:growth & development*; D006801:Humans; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D014953:Wrist / Q000254:growth & development*