title: A clinical study of autologous bone marrow mononuclear cells for cerebral palsy patients: a new frontier.
abstract: Cerebral palsy is a nonprogressive heterogeneous group of neurological disorders with a growing rate of prevalence. Recently, cellular therapy is emerging as a potential novel treatment strategy for cerebral palsy. The various mechanisms by which cellular therapy works include neuroprotection, immunomodulation, neurorestoration, and neurogenesis. We conducted an open label, nonrandomized study on 40 cases of cerebral palsy with an aim of evaluating the benefit of cellular therapy in combination with rehabilitation. These cases were administered autologous bone marrow mononuclear cells intrathecally. The follow-up was carried out at 1 week, 3 months, and 6 months after the intervention. Adverse events of the treatment were also monitored in this duration. Overall, at six months, 95% of patients showed improvements. The study population was further divided into diplegic, quadriplegic, and miscellaneous group of cerebral palsy. On statistical analysis, a significant association was established between the symptomatic improvements and cell therapy in diplegic and quadriplegic cerebral palsy. PET-CT scan done in 6 patients showed metabolic improvements in areas of the brain correlating to clinical improvements. The results of this study demonstrate that cellular therapy may accelerate the development, reduce disability, and improve the quality of life of patients with cerebral palsy.
authors: Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Alok
authors: A
authors: Sharma
authors: Department of Research & Development, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Hemangi
authors: H
authors: Sane
authors: Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Nandini
authors: N
authors: Gokulchandran
authors: Department of Research & Development, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Pooja
authors: P
authors: Kulkarni
authors: Department of NeuroRehabilitation, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Sushant
authors: 0000-0002-6762-0867
authors: S
authors: Gandhi
authors: Department of NeuroRehabilitation, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Jyothi
authors: J
authors: Sundaram
authors: Department of NeuroRehabilitation, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Amruta
authors: A
authors: Paranjape
authors: Department of NeuroRehabilitation, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Akshata
authors: A
authors: Shetty
authors: Department of Research & Development, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Khushboo
authors: K
authors: Bhagwanani
authors: Department of NeuroRehabilitation, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Hema
authors: H
authors: Biju
authors: Department of Medical Services and Clinical Research, NeuroGen Brain & Spine Institute, Stem Asia Hospital and Research Centre, Sector 40, Plot No. 19, Palm Beach Road, Seawood (W), Navi Mumbai 400706, India.
authors: Prerna
authors: P
authors: Badhe