title: Induction of apoptosis by hypertension via endoplasmic reticulum stress.
abstract: OBJECTIVE
  Endoplasmic reticulum (ER) stress is one of the intrinsic apoptosis pathways, and cardiac apoptosis can occur in cardiovascular diseases, such as hypertension. However, the mechanisms by which ER stress leads to apoptosis remain enigmatic, particularly in the progression from cardiac hypertrophy to diastolic heart failure due to hypertension.
  
  
  METHODS
  We used spontaneously hypertensive rats (SHRs) to investigate possible signalling pathways for ER stress.
  
  
  RESULTS
  We found that cardiac protein and mRNA levels of glucoseregulated protein 78 were up-regulated. In addition, the CHOP- and caspase-12-dependent pathways, but not that of JNK, were activated in the SHR rats.
  
  
  CONCLUSIONS
  These results suggest that ER stress can contribute to myocardial apoptosis during hypertensive disease.
authors: Yingying
authors: Y
authors: Sun
authors: Tong
authors: T
authors: Zhang
authors: Li
authors: L
authors: Li
authors: Ji
authors: J
authors: Wang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006973:Hypertension / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY