title: Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies.
abstract: TheGSTT1gene encodes a key enzyme involved in the metabolism of xenobiotics and its polymorphisms have been associated with individual susceptibility to various malignancies. Numerous molecular epidemiological studies have been performed to investigate the association betweenGSTT1gene polymorphisms and lung cancer susceptibility; however, the results of previous studies were inconsistent. Therefore, the aim of the present study was to conduct a meta-analysis in order to derive a more precise estimation of the association in the East Asian populations. The meta-analysis included 7,415 lung cancer cases and 6,084 controls from 26 published studies in East Asia, which were selected from the PubMed and China National Knowledge Infrastructure databases, up to March 20, 2014. Using crude odds ratios (ORs) with 95% confidence intervals (CIs), a statistically significant association was identified between theGSTT1null genotype and lung cancer in the East Asian populations (OR=1.17; 95% CI, 1.09-1.25; Pheterogeneity=0.003). Furthermore, subgroup analyses revealed that the lung cancer risk in smokers carrying theGSTT1null genotype was significantly increased compared with non-smokers (OR=1.71; 95% CI, 1.04-2.81; Pheterogeneity=0.002). Thus, theGSTT1null genotype may increase the risk of lung cancer among the East Asian populations.
authors: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China ; Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
authors: Yan
authors: Y
authors: Zhao
authors: Department of Social Medicine and Health Service Management, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors: Bingwei
authors: B
authors: Wang
authors: Henan Academy of Medical Sciences, Zhengzhou, Henan 450003, P.R. China.
authors: Kai
authors: K
authors: Hu
authors: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors: Juan
authors: J
authors: Wang
authors: Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China.
authors: S U
authors: SU
authors: Lu
authors: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China ; Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
authors: Yanxi
authors: Y
authors: Zhang
authors: Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
authors: Weiquan
authors: W
authors: Lu
authors: Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
authors: Erjiang
authors: E
authors: Zhao
authors: Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.
authors: Ling
authors: L
authors: Yuan
keywords: glutathione S-transferase θ1; lung cancer; meta-analysis; polymorphism