title: Haploidentical stem cell transplantation in patients aged 50 yr and older with leukemia: similar outcomes compared to younger adults.
abstract: OBJECTIVE
  We aimed to analyze the complications and survival associated with myeloablative haploidentical SCT in patients aged ≥ 50 yr and compare these results with a younger group population.
  
  
  METHODS
  In this case-control study, enrolled patients with leukemia were identified from 1262 patients between May 2002 and May 2013 at a single institution.
  
  
  RESULTS
  Thirty-one patients were aged ≥ 50 yr (the older group) and 165 patients were aged 18-49 yr (the younger group). Of the older group, 20 of 31 (64.5%) had a hematopoietic cell transplantation comorbidity index (HCT-CI) of 0 or 2. Statistical analysis showed no significant differences in the incidences of grades II to IV acute GVHD, extensive chronic GVHD, and non-relapse mortality (NRM), or probability of relapse between the two groups. Furthermore, the 3-yr overall survival (OS) and leukemia-free survival (LFS) were not significantly different between the older and younger groups: 67.0 ± 9.3% vs. 75.3 ± 3.4% (p = 0.406) and 60.5 ± 9.6% vs. 72.5 ± 3.5% (p = 0.183), respectively.
  
  
  CONCLUSIONS
  Selected older patients aged ≥ 50 yr with low HCT-CI and good performance status could safely undergo haploidentical SCT.
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Yao
authors: Y
authors: Chen
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Yu
authors: Y
authors: Wang
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Lan-Ping
authors: LP
authors: Xu
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Kai-Yan
authors: KY
authors: Liu
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Huan
authors: H
authors: Chen
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Yu-Hong
authors: YH
authors: Chen
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Xiao-Hui
authors: XH
authors: Zhang
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Feng-Rong
authors: FR
authors: Wang
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Wei
authors: W
authors: Han
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Jing-Zhi
authors: JZ
authors: Wang
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Chen-Hua
authors: CH
authors: Yan
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Yuan-Yuan
authors: YY
authors: Zhang
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.
authors: Yu-Qian
authors: YQ
authors: Sun
authors: Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.|Peking-Tsinghua Center for Life Sciences, Beijing, China.
authors: Xiao-Jun
authors: XJ
authors: Huang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use; D012189:Retrospective Studies; D016019:Survival Analysis; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019653:Myeloablative Agonists
keywords: HLA; age; haploidentical; leukemia; stem cell transplantation