title: Distribution of perfluorooctane sulfonate isomers and predicted risk of thyroid hormonal perturbation in drinking water.
abstract: We documented the distribution of seven perfluorooctane sulfonate (PFOS) isomers in drinking water in Jiangsu Province, China. Compared to the 30% proportion of branched PFOS in technical PFOS, the levels of branched PFOS in drinking water increased to 31.8%-44.6% of total PFOS. Because of previous risk assessment without considering the PFOS isomer profile and the toxicity of individual PFOS isomers, here we performed a new health risk assessment of PFOS for thyroid hormonal perturbation in drinking water with the contribution from individual PFOS isomers. The risk quotients (RQs) of individual PFOS isomers indicated that linear PFOS contributed most to the risk among all the target PFOS isomers (83.0%-90.2% of the total PFOS RQ), and that risk from 6m-PFOS (5.2%-11.9% of the total PFOS RQ) was higher than that from other branched PFOS isomers. We found that the risks associated with PFOS in drinking water would be overestimated by 10.0%-91.7% if contributions from individual PFOS isomers were not considered. The results revealed that the PFOS isomer profile and the toxicity of individual PFOS isomers were important factors in health risk assessment of PFOS and should be considered in the future risk assessments.
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Nanyang
authors: N
authors: Yu
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Xiaoxiang
authors: X
authors: Wang
authors: State Environmental Protection Key Laboratory of Monitoring and Analysis for Organic Pollutants in Surface Water, Jiangsu Provincial Environmental Monitoring Center, Nanjing, PR China.
authors: Beibei
authors: B
authors: Zhang
authors: Laboratory of Immunology and Reproductive Biology, School of Medicine, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Jingping
authors: J
authors: Yang
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Meiying
authors: M
authors: Li
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Jun
authors: J
authors: Li
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China.
authors: Wei
authors: W
authors: Shi
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China. Electronic address: weisi@nju.edu.cn.
authors: Si
authors: S
authors: Wei
authors: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu, PR China. Electronic address: yuhx@nju.edu.cn.
authors: Hongxia
authors: H
authors: Yu
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D060766:Drinking Water / Q000737:chemistry*; D052244:Endocrine Disruptors / Q000737:chemistry / Q000494:pharmacology*; D005466:Fluorocarbons / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007536:Isomerism; D018570:Risk Assessment; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000737:chemistry / Q000494:pharmacology
chemical_list: D017738:Alkanesulfonic Acids; D060766:Drinking Water; D052244:Endocrine Disruptors; D005466:Fluorocarbons; D013963:Thyroid Hormones; D014874:Water Pollutants, Chemical; C076994:perfluorooctane sulfonic acid
keywords: Branched isomer; Health risk assessment; Isomer specific method; Perfluorooctane sulfonate