title: Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging.
abstract: The correlation of physiological sensitivity to insulin ( vis-à-vis glycemic regulation) and longevity is extensively established, creating a justifiable gerontological interest on whether insulin sensitivity is causative, or even predictive, of some or all phenotypes of slowed senescence (including longevity). The growth hormone receptor/ binding protein gene-disrupted (GHR-KO) mouse is the most extensively investigated insulin-sensitive, attenuated aging model. It was reported that, in a manner divergent from similar mutants, GHR-KO mice fail to respond to caloric restriction (CR) by altering their insulin sensitivity. We hypothesized that maximized insulin responsiveness is what causes GHR-KO mice to exhibit a suppressed survivorship response to dietary (including caloric) restriction; and attempted to refute this hypothesis by assessing the effects of CR on GHR-KO mice for varied slow-aging-associated phenotypes. In contrast to previous reports, we found GHR-KO mice on CR to be less responsive than their ad libitum (A.L.) counterparts to the hypoglycemia-inducing effects of insulin. Further, CR had negligible effects on the metabolism or cognition of GHR-KO mice. Therefore, our data suggest that the effects of CR on the insulin sensitivity of GHR-KO mice do not concur with the effects of CR on the aging of GHR-KO mice.
authors: Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
authors: Oge
authors: O
authors: Arum
authors: Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
authors: Jamal
authors: J
authors: Saleh
authors: Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
authors: Ravneet
authors: R
authors: Boparai
authors: Department of Surgery, Division of ENT-Otolaryngology, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
authors: Jeremy
authors: J
authors: Turner
authors: Edison Biotechnology Institute and Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.
authors: John
authors: J
authors: Kopchick
authors: Department of Internal Medicine, Division of Endocrinology & Metabolism, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
authors: Romesh
authors: R
authors: Khardori
authors: Department of Internal Medicine, Southern Illinois University-School of Medicine, Springfield, IL, 62794, USA.
authors: Andrzej
authors: A
authors: Bartke
keywords: Longevity regulation; endocrinology & metabolism; insulin sensitivity; growth hormone hormonal signaling; caloric restriction; (neuro)endocrinology of senescence