title: Modified hydroxypropyl methyl cellulose: Efficient matrix for controlled release of 5-amino salicylic acid.
abstract: Hydroxypropyl methyl cellulose has been modified by grafting synthetic polyacrylamide chains [g-HPMC (M)] in presence of microwave irradiation, which has used as carrier for controlled release of 5-amino salicylic acid (5-ASA). The FTIR and UV-vis-NIR studies reveal the excellent compatibility between g-HPMC (M) and 5-ASA. Field emission scanning electron microscopy (FESEM) and UV-vis-NIR analyses suggest that physical interaction predominates between the drug and matrix. % equilibrium swelling ratio (% ESR) of g-HPMC (M) decreased with addition of salt solutions and follow the order: Na(+)>K(+)>Mg(2+)>Ca(2+)>Al(3+). The in vitro 5-ASA release studies indicate that g-HPMC (M) delivers the drug preferentially in colonic region in more sustained way than that of HPMC. The 5-ASA release follows first order kinetics and non-Fickian diffusion mechanism. These favorable features make the graft copolymer a potential matrix for colon specific delivery of 5-ASA.
authors: Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad 826004, India.
authors: Raghunath
authors: R
authors: Das
authors: Polymer Chemistry Laboratory, Department of Applied Chemistry, Indian School of Mines, Dhanbad 826004, India. Electronic address: sagarpal1@hotmail.com.
authors: Sagar
authors: S
authors: Pal
mesh_terms: D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020100:Hydrogels / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry*; D007700:Kinetics; D019804:Mesalamine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D012492:Salts / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D012492:Salts; D065347:Hypromellose Derivatives; D019804:Mesalamine
keywords: 5-Amino salicylic acid; Controlled drug release; HPMC