title: Regulation of miRNAs affects radiobiological response of lung cancer stem cells.
abstract: Radiotherapy (RT) is a key therapeutic strategy for lung cancer, the most common cause of cancer-related deaths worldwide, but radioresistance often occurs and leads to failure of RT. It is therefore important to clarify the mechanism underlying radioresistance in lung cancer. Cancer stem cells (CSCs) are considered the fundamental reason for radioresistance. MicroRNAs (miRNAs) have been regarded as important regulatory molecules of CSCs, carcinogenesis, and treatment response of cancers. It is crucial to clarify how regulation of miRNAs affects repair of DNA damage, redistribution, repopulation, reoxygenation, and radiosensitivity (5R) of lung cancer stem cells (LCSCs). A thorough understanding of the regulation of miRNAs affecting 5R of LCSCs has potential impact on identifying novel targets and thus may improve the efficacy of lung cancer radiotherapy.
authors: Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China.
authors: Yan-mei
authors: YM
authors: Xu
authors: Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China.
authors: Xing-yun
authors: XY
authors: Liao
authors: Medical English Department, College of Basic Medicine, Third Military Medical University, Shapingba District, Chongqing 400038, China.
authors: Xie-wan
authors: XW
authors: Chen
authors: Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China.
authors: De-zhi
authors: DZ
authors: Li
authors: Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China.
authors: Jian-guo
authors: JG
authors: Sun
authors: Medical English Department, College of Basic Medicine, Third Military Medical University, Shapingba District, Chongqing 400038, China.
authors: Rong-xia
authors: RX
authors: Liao
mesh_terms: D063646:Carcinogenesis / Q000235:genetics / Q000528:radiation effects; D004249:DNA Damage / Q000528:radiation effects; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D011836:Radiation Tolerance
chemical_list: D035683:MicroRNAs