title: Importance of interferon inducible trans-membrane proteins and retinoic acid inducible gene I for influenza virus replication: A review.
abstract: Understanding the interplay between Influenza viruses and host cells is key to elucidating the pathogenesis of these viruses. Several host factors have been identified that exert antiviral functions; however, influenza viruses continue to replicate utilizing host cell machinery. Herein, we review the mechanisms of action of two host-derived proteins on conferring cellular resistance to the influenza virus; (1) the interferon inducible trans-membrane proteins, 1, 2 and 3, a recently identified family of early restriction factors; and (2) retinoic acid inducible gene I, a key mediator of antiviral immunity. These data may contribute to the design of novel and efficient anti-influenza treatments.
authors: a College of Veterinary Medicine, Northeast Agricultural University , Xiangfang , Harbin , China.
authors: Siqingaowa
authors: S
authors: Suo
authors: a College of Veterinary Medicine, Northeast Agricultural University , Xiangfang , Harbin , China.
authors: Xiaofeng
authors: X
authors: Ren
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics / Q000378:metabolism*; D060467:Disease Resistance; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007109:Immunity; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D009975:Orthomyxoviridae / Q000502:physiology*; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000821:virology*; D011991:Receptors, Virus / Q000378:metabolism; D015398:Signal Transduction; D014779:Virus Replication
chemical_list: D000943:Antigens, Differentiation; D008565:Membrane Proteins; D011991:Receptors, Virus
keywords: Antiviral immunity; influenza virus; signal pathway