title: Neutrophil-to-lymphocyte ratio as a prognostic marker in infective endocarditis: in-hospital and long-term clinical results.
abstract: OBJECTIVE
  The neutrophil-to-lymphocyte ratio (NLR) is an independent predictor of poor prognosis in different clinical conditions such as infectious and cardiovascular diseases. It was hypothesized that a patient's admission NLR would be predictive of an adverse clinical outcome in cases of infective endocarditis (IE).
  
  
  METHODS
  A total of 171 patients with IE was enrolled retrospectively, and allocated to two tertiles based on admission NLR values. The high-NLR group (n = 76) was defined as having an NLR value in the third tertile (> 5.46), and the low-NLR group (n = 95) as having a value in the lower two tertiles (≤ 5.46).
  
  
  RESULTS
  Patients in the high-NLR group had a significantly higher incidence of in-hospital mortality than the low-NLR group (39.4% versus 18.9%, p = 0.003). A high NLR was found to be an independent predictor of in-hospital mortality (odds ratio 2.53, 95% confidence interval 1.19-5.3; p = 0.01). The mean follow up was 25.5 months, and long-term follow up mortality was similar in both groups (12.9% versus 19.5%; p = 0.33).
  
  
  CONCLUSIONS
  A high NLR at admission is associated with increased in-hospital mortality in patients with IE. During the long-term follow up, NLR showed no predictive indication of mortality.
authors: Mehmet
authors: M
authors: Bozbay
authors: Murat
authors: M
authors: Ugur
authors: Huseyin
authors: H
authors: Uyarel
authors: Gokhan
authors: G
authors: Cicek
authors: Bayram
authors: B
authors: Koroglu
authors: Eyyup
authors: E
authors: Tusun
authors: Murat
authors: M
authors: Sunbul
authors: Ahmet
authors: A
authors: Murat
authors: Ibrahim
authors: I
authors: Sari
authors: Mehmet
authors: M
authors: Eren
mesh_terms: D000328:Adult; D000368:Aged; D004696:Endocarditis / Q000150:complications / Q000276:immunology* / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors