title: Serum levels of HGF, IL-6, and TGF-α after benign liver tumor resection.
abstract: OBJECTIVE
  Literature is void of data on the relationship between pre- and postoperative levels of hepatocyte growth factor (HGF), interleukin 6 (IL-6), and tumor growth factor α (TGF-α) after liver resection performed for particular benign liver tumors. The purpose of this study was to assess whether there is a different degree of liver regeneration through the kinetics of HGF, IL-6, and TGF-α in 2 particular types of benign liver lesions.
  
  
  METHODS
  The study included 9 patients diagnosed with hepatic hemangioma and 13 patients with focal nodular hyperplasia (FNH) who underwent liver resection. HGF, IL-6, and TGF-α were measured using enzyme-linked immunosorbent assay (ELISA) from blood serum drawn at 6 time points during an 8-day period. Statistical analysis was based on two-factor variance analysis with replicate measurements.
  
  
  RESULTS
  The HGF, IL-6, and TGF-α levels in patients who underwent FNH resection were not significantly different from the levels observed in hemangioma resection patients. Significant increases in HGF, IL-6, and TGF-α concentrations were observed only during the first 24h after resection in both groups of patients.
  
  
  CONCLUSIONS
  Obtained results suggest that the pre- and post-operative levels of HGF, IL-6, and TGF-α do not depend on the particular type of benign tumor. After resection of FNH and hemangioma tumors, the serum levels of HGF, IL-6, and TGF-α increased at similar rates during the first 24h, followed by significant declines back to pre-operative levels.
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland. Electronic address: oskar.kornasiewicz@gmail.com.
authors: Oskar
authors: O
authors: Kornasiewicz
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.
authors: Michał
authors: M
authors: Grąt
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.
authors: Krzysztof
authors: K
authors: Dudek
authors: Department of Epidemiology, Medical University of Warsaw, Poland.
authors: Zbigniew
authors: Z
authors: Lewandowski
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.
authors: Zuzanna
authors: Z
authors: Gorski
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.
authors: Krzysztof
authors: K
authors: Zieniewicz
authors: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland.
authors: Marek
authors: M
authors: Krawczyk
mesh_terms: D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood* / Q000601:surgery*; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016211:Transforming Growth Factor alpha / Q000097:blood*
chemical_list: C066855:HGF protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016211:Transforming Growth Factor alpha; D017228:Hepatocyte Growth Factor
keywords: Benign liver tumor; FNH; Hemangioma; Liver resection