title: Ovarian tissue freezing: current status.
abstract: OBJECTIVE
  This article aims to carefully evaluate a number of critical points related to ovarian tissue freezing and presents factual data in terms of live birth rates and risks.
  
  
  RESULTS
  Reimplantation of frozen-thawed ovarian tissue remains an experimental procedure according to the American Society for Reproductive Medicine, despite almost 40 live births reported in the literature. Recent literature on the topic has focused on the risk of reimplanting malignant cells, so the present review assesses the risks according to disease.
  
  
  CONCLUSIONS
  This manuscript emphasizes the crucial importance of not only preserving fertility in young women but also clearly explaining to patients the different available options and their respective success rates. Some previously published reviews have reported inaccurate reimplantation success rates. In this review, we report the true picture, with a live birth rate of 25%. Ovarian tissue freezing may be combined with pickup of immature oocytes (at the time of ovarian biopsy and tissue removal) or mature oocytes (if chemotherapy can be delayed).
authors: aInfertility Research Unit, Société de Recherche pour l'Infertilité (SRI) bGynecology Research Unit, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, Belgium.
authors: Jacques
authors: J
authors: Donnez
authors: Marie-Madeleine
authors: MM
authors: Dolmans
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D015925:Cryopreservation / Q000379:methods*; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D012099:Reproductive Techniques; D016378:Tissue Transplantation / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents