title: Assessment of four experimental models of hyperlipidemia.
abstract: Various animal models of hyperlipidemia are used in research. Four rodent hyperlipidemia experimental models are examined in this study: three chronic hyperlipidemia models based on dietary supplementation with lipid or sucrose for 3 months and one acute hyperlipidemia model based on administration of the nonionic surfactant poloxamer. Neither lipid supplementation nor sucrose supplementation in Wistar rats was effective for establishing hyperlipidemia. Combining both lipid and sucrose supplementation in BALB/c mice induced hypercholesterolemia, as reflected in a considerable increase in blood cholesterol concentration, but did not produce an increase in blood triglyceride concentration. Poloxamer administration in C57BL/J6 mice produced increases in blood cholesterol and triglyceride concentrations. The authors conclude that supplementation of both lipid and sucrose in BALB/c mice was the most effective method for developing chronic hypercholesterolemia.
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: Yisel González
authors: YG
authors: Madariaga
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: María Boffill
authors: MB
authors: Cárdenas
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: Maibia Tamayo
authors: MT
authors: Irsula
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: Orestes Castillo
authors: OC
authors: Alfonso
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: Bennia Alfonso
authors: BA
authors: Cáceres
authors: Department of Experimental Research, Toxicology Center, Medical College of Villa Clara, Villa Clara, Cuba.
authors: Emoe Betancourt
authors: EB
authors: Morgado
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000818:Animals; D004032:Diet; D019587:Dietary Supplements; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000209:etiology*; D008055:Lipids / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020442:Poloxamer / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D008055:Lipids; D020442:Poloxamer; D013395:Sucrose