title: Clinical role of Foxp3+ regulatory T cell in Living donor related liver transplantation for prediction of life-threatening complications.
abstract: OBJECTIVE
  It is no doubt that regulatory T cells (Foxp3(+)CD4(+)CD25(+)T cells: Treg) play important roles in transplant immunity. We investigated the significance of Treg expression in acute stage of living donorrelated liver transplantation (LDLT) for the possibility of the sensitive marker for immunological state and homeostatic stress after liver transplantation.
  
  
  METHODS
  Peripheral blood was drawn from 5 recipients of LDLT preoperatively and on post operative 1, 4, 7, and 14 days. The peripheral blood mononuclear cells (PBMCs) were stained with CD4, CD25, Foxp3, and were analyzed with FACScan. This data was compared with clinical output of LDLT.
  
  
  RESULTS
  The populations of Treg were significantly decreased in all patients on day 1 after LDLT and significantly increased in patients who had early postoperative complications compared with patients who had no complications.
  
  
  CONCLUSIONS
  The population of Treg in peripheral blood may reflect the surgical stress such as life-threatening complications after LDLT.
authors: The Department of Surgery, the University of Tokushima.
authors: Michihito
authors: M
authors: Asanoma
authors: Hiroki
authors: H
authors: Mori
authors: Tetsuya
authors: T
authors: Ikemoto
authors: Toru
authors: T
authors: Utsunomiya
authors: Satoru
authors: S
authors: Imura
authors: Yuji
authors: Y
authors: Morine
authors: Jun
authors: J
authors: Hanaoka
authors: Mami
authors: M
authors: Kanamoto
authors: Yu
authors: Y
authors: Saito
authors: Shinichiro
authors: S
authors: Yamada
authors: Mitsuo
authors: M
authors: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors