title: An enantioselective approach to functionalized amino acids: total synthesis of antiepileptic drug (R)-lacosamide.
abstract: A short and highly efficient synthetic approach to enantiopure functionalized amino acids (FAAs) 1 skeleton from racemic butadiene monoepoxide as a starting material and its application to the total synthesis of an antiepileptic drug (R)-lacosamide 2 are described. The synthesis utilizes the palladium catalyzed Trost's Dynamic Kinetic Asymmetric Transformation (DYKAT) as key step.
authors: School of Chemistry and Biochemistry, Thapar University, Patiala 147001, India.
authors: Yuvraj
authors: Y
authors: Garg
authors: School of Chemistry and Biochemistry, Thapar University, Patiala 147001, India.
authors: Satyendra Kumar
authors: SK
authors: Pandey
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D007700:Kinetics; D000078334:Lacosamide; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000081:Acetamides; D000596:Amino Acids; D000927:Anticonvulsants; D004852:Epoxy Compounds; C024370:3,4-epoxy-1-butene; D000078334:Lacosamide