title: Default mode network, motor network, dorsal and ventral basal ganglia networks in the rat brain: comparison to human networks using resting state-fMRI.
abstract: Rodent models are developed to enhance understanding of the underlying biology of different brain disorders. However, before interpreting findings from animal models in a translational aspect to understand human disease, a fundamental step is to first have knowledge of similarities and differences of the biological systems studied. In this study, we analyzed and verified four known networks termed: default mode network, motor network, dorsal basal ganglia network, and ventral basal ganglia network using resting state functional MRI (rsfMRI) in humans and rats. Our work supports the notion that humans and rats have common robust resting state brain networks and that rsfMRI can be used as a translational tool when validating animal models of brain disorders. In the future, rsfMRI may be used, in addition to short-term interventions, to characterize longitudinal effects on functional brain networks after long-term intervention in humans and rats.
authors: Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
authors: Adam
authors: A
authors: Sierakowiak
authors: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors: Cyril
authors: C
authors: Monnot
authors: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors: Sahar Nikkhou
authors: SN
authors: Aski
authors: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors: Martin
authors: M
authors: Uppman
authors: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors: Tie-Qiang
authors: TQ
authors: Li
authors: Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
authors: Peter
authors: P
authors: Damberg
authors: Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
authors: Stefan
authors: S
authors: Brené
mesh_terms: D000328:Adult; D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging* / Q000502:physiology; D001927:Brain Diseases / Q000503:physiopathology; D001931:Brain Mapping; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D023421:Models, Animal; D009415:Nerve Net / Q000502:physiology*; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley