title: Conventional diagnostic challenges in periprosthetic joint infection.
abstract: Periprosthetic joint infection remains a clinical challenge with no benchmark for diagnosis. The diagnosis is based on many different clinical variables that may be difficult to interpret, especially in the setting of chronic systemic disease. Synovial fluid aspiration, diagnostic imaging, traditional culture, peripheral serum inflammatory markers, and intraoperative frozen sections each have their limitations but continue to be the mainstay for diagnosis of periprosthetic joint infection. As molecular- and biomarker-based technologies improve, the way we interpret and diagnose periprosthetic joint infection will ultimately change and may even improve diagnostic accuracy and turnaround time. Future research on this topic should be focused on improving diagnostic criteria for low-virulence organisms, improving interpretation of intraoperative frozen sections, and establishing improved synovial fluid and peripheral serum biomarker profiles for periprosthetic joint infection.
authors: Scott R
authors: SR
authors: Nodzo
authors: Thomas
authors: T
authors: Bauer
authors: Paul S
authors: PS
authors: Pottinger
authors: Grant E
authors: GE
authors: Garrigues
authors: Hany
authors: H
authors: Bedair
authors: Carl A
authors: CA
authors: Deirmengian
authors: John
authors: J
authors: Segreti
authors: Kevin J
authors: KJ
authors: Blount
authors: Imran M
authors: IM
authors: Omar
authors: Javad
authors: J
authors: Parvizi
mesh_terms: D001170:Arthritis, Infectious / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D015415:Biomarkers / Q000097:blood; D005629:Frozen Sections; D006801:Humans; D016459:Prosthesis-Related Infections / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D013582:Synovial Fluid / Q000382:microbiology*; D014774:Virulence
chemical_list: D015415:Biomarkers