title: Biological markers, lifestyles and metabolic syndrome in workers.
abstract: OBJECTIVE
  The association between metabolic syndrome (MetS) and biological inflammatory or anti-coagulant markers were clarified in combination with lifestyle factors.
  
  
  METHODS
  The target subjects were 5102 working men without metabolic diseases, aged 30-60 years old. The authors measured the serum levels of high-sensitivity C-reactive protein (CRP), uric acid and plasma fibrinogen as potential key biomarkers of MetS.
  
  
  RESULTS
  Mean values of uric acid, log-transformed serum CRP and plasma fibrinogen increased significantly as the number of components of MetS increased after adjustment for age. Multivariate analysis revealed significant associations between the presence of MetS and age, habitual exercise, not current smoking, the log-transformed value of serum CRP and serum uric acid, with odds ratios (ORs) of 1.03 (95% confidence interval (CI): 1.02-1.04; p<0.001), 0.77 (95% CI: 0.65-0.90; p<0.01), 0.82 (95% CI: 0.70-0.96; p<0.05), 3.2 (95% CI: 2.6-3.9; p<0.001) and 1.5 (95% CI: 1.4-1.6; p<0.001), respectively for the presence of MetS.
  
  
  CONCLUSIONS
  Elevated serum level of CRP, uric acid, not habitual exercise and current smoking were associated with MetS in this cross-sectional study.
authors: Department of Hygiene and Public Health, Nippon Medical School, Japan. Electronic address: kawada@nms.ac.jp.
authors: Tomoyuki
authors: T
authors: Kawada
authors: Department of Hygiene and Public Health, Nippon Medical School, Japan.
authors: Toshiaki
authors: T
authors: Otsuka
authors: Department of Hygiene and Public Health, Nippon Medical School, Japan.
authors: Hirofumi
authors: H
authors: Inagaki
authors: Department of Hygiene and Public Health, Nippon Medical School, Japan.
authors: Yoko
authors: Y
authors: Wakayama
authors: Department of Hygiene and Public Health, Nippon Medical School, Japan.
authors: Masao
authors: M
authors: Katsumata
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D005340:Fibrinogen; D002097:C-Reactive Protein
keywords: C-reactive protein; Fibrinogen; Lifestyle factors; Metabolic syndrome; Uric acid