title: Chronic lithium treatment diminishes the female advantage in lifespan in Drosophila melanogaster.
abstract: Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D. melanogaster and that the drug abolishes the female lifespan advantage in flies.
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Fengge
authors: F
authors: Zhu
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Qinggang
authors: Q
authors: Li
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Fujian
authors: F
authors: Zhang
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Xuefeng
authors: X
authors: Sun
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Guangyan
authors: G
authors: Cai
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Weiguang
authors: W
authors: Zhang
authors: Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China.
authors: Xiangmei
authors: X
authors: Chen
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology; D004334:Drug Administration Schedule; D005260:Female; D018021:Lithium Chloride / Q000008:administration & dosage*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008297:Male; D012727:Sex Characteristics; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
chemical_list: D018021:Lithium Chloride
keywords: ageing; lithium; sex difference