title: Expression of endothelin-1 and endothelin-1 receptor A in canine mammary tumours.
abstract: Endothelins and their receptors have been implicated in numerous diseases and have recently emerged as relevant players in a variety of malignancies. Tumours overexpress the Endothelin-1 (ET-1) and the Endothelin-A receptors (ETAR) and their interaction enhances tumour growth and metastasis by promoting tumour cell survival, proliferation and angiogenesis. In this study we have evaluated the expression of ET-1 and ETAR in 50 canine mammary tumours, compared to normal controls. Results demonstrated a progressive increase in ET-1 and ETAR expression from benign tumour to grade 1 and to grade 2 malignant mammary tumours with a decrease of expression in grade 3 carcinomas. Co-localization of ET-1 and ETAR was observed in benign mammary tumours and in G1 and G2 carcinomas, while absent in G3 carcinomas. Concluding, ET-1/ETAR can be considered reliable markers for evaluating malignancy of canine mammary tumours and could have importance for the development of specific anticancer therapies.
authors: Department of Veterinary Medicine and Animal Production, Naples University "Federico II", Via F. Delpino 1, 80137 Naples, Italy. Electronic address: restucci@unina.it.
authors: B
authors: B
authors: Restucci
authors: Department of Veterinary Medicine and Animal Production, Naples University "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
authors: M
authors: M
authors: Martano
authors: Department of Veterinary Medicine and Animal Production, Naples University "Federico II", Via F. Delpino 1, 80137 Naples, Italy.
authors: P
authors: P
authors: Maiolino
mesh_terms: D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D002277:Carcinoma / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology / Q000378:metabolism*; D004285:Dogs; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D015674:Mammary Neoplasms, Animal / Q000209:etiology / Q000378:metabolism*; D044022:Receptor, Endothelin A / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D044022:Receptor, Endothelin A
keywords: Angiogenesis; Dog; Endothelin-1; Endothelin-A-receptor; Mammary tumours