title: Comparison of efficacy and safety between rabbit anti-thymocyte globulin and anti-T lymphocyte globulin in kidney transplantation from donation after cardiac death: a retrospective cohort study.
abstract: OBJECTIVE
  To compare the efficacy and safety between rabbit anti-thymocyte globulin (Thymoglobulin) and anti-T lymphocyte globulin (ATG-Fresenius, ATG-F) in donation after cardiac death (DCD) kidney transplantation.
  
  
  METHODS
  We retrospectively analyzed 255 cases of DCD kidney transplantation performed at our hospital from February 2007 to October 2013. The patients were divided into two groups based on their induction therapies with Thymoglobulin (n = 188) or ATG-F (n = 67). Clinical data were collected and compared between the two groups.
  
  
  RESULTS
  Delayed graft function (DGF) occurred in 36 (19.1%) patients in the Thymoglobulin group versus 17 (25.4%) patients in the ATG-F group (P = 0.281). However, if we subgroup the patients with increased risk factors for DGF, the DGF rate was 9/40 (22.5%) in the Thymoglobulin group versus 9/16 (56.3%) in the ATG-F group (P = 0.015). Duration of DGF was significantly shorter in the Thymoglobulin group (11.7 days vs. 16.1 days). The acute rejection rate was significantly lower in the Thymoglobulin group (9.6% vs. 19.4%, P = 0.035). One-year graft and patient survival were both comparable between the Thymoglobulin and ATG-F groups. The adjusted odds ratio of DGF was 4.283 (1.137-16.13) between the ATG-F and Thymoglobulin groups in patients with increased risk factors for DGF.
  
  
  CONCLUSIONS
  Compared with ATG-F, Thymoglobulin may reduce duration of DGF and acute rejection rate after DCD kidney transplantation. Moreover, Thymoglobulin significantly reduced DGF in patients with increased risk factors for DGF.
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Guo-Dong
authors: GD
authors: Chen
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Xing-Qiang
authors: XQ
authors: Lai
authors: Departments of Urology and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors: Dicken Shiu-Chung
authors: DS
authors: Ko
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Jiang
authors: J
authors: Qiu
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Chang-Xi
authors: CX
authors: Wang
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Ming
authors: M
authors: Han
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Jun
authors: J
authors: Li
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Gang
authors: G
authors: Huang
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Xiao-Shun
authors: XS
authors: He
authors: Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors: Li-Zhong
authors: LZ
authors: Chen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000961:Antilymphocyte Serum / Q000009:adverse effects / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D051799:Delayed Graft Function / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D006085:Graft Survival / Q000187:drug effects; D006331:Heart Diseases / Q000401:mortality*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors; D013601:T-Lymphocytes / Q000276:immunology*; D060168:Thymocytes / Q000276:immunology*; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents
keywords: anti-T lymphocyte globulin; donation after cardiac death; kidney transplantation; rabbit anti-thymocyte globulin