title: From the GPS to HM: Place cells, grid cells, and memory.
abstract: A longstanding debate in hippocampus research has revolved around how to reconcile spatial mapping functions of the hippocampus with the global amnesia produced by hippocampal damage in humans. Is the hippocampus primarily a cognitive map used to support spatial learning, or does it support more general types of learning necessary for declarative memory? In recent years, a general consensus has emerged that the hippocampus receives both spatial and nonspatial inputs from the entorhinal cortex. The hippocampus creates representations of experience in a particular spatial and temporal context. This process allows the individual components of experience to be stored in such a way that they can be retrieved together as a conscious recollection.
authors: Zanvyl Krieger Mind/Brain Institute, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland.
authors: James J
authors: JJ
authors: Knierim
mesh_terms: D000818:Animals; D001931:Brain Mapping; D018728:Entorhinal Cortex / Q000166:cytology*; D006624:Hippocampus / Q000166:cytology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000145:classification / Q000502:physiology*; D013028:Space Perception; D013037:Spatial Behavior / Q000502:physiology*
keywords: entorhinal cortex; grid cells; memory; place cells