title: The pathways by which mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury.
abstract: Several studies have demonstrated that mild hypothermia exhibits a neuroprotective role and it can inhibit endothelial cell apoptosis following ischemia/reperfusion injury by decreasing caspase-3 expression. It is hypothesized that mild hypothermia exhibits neuroprotective effects on neurons exposed to ischemia/reperfusion condition produced by oxygen-glucose deprivation. Mild hypothermia significantly reduced the number of apoptotic neurons, decreased the expression of pro-apoptotic protein Bax and increased mitochondrial membrane potential, with the peak of anti-apoptotic effect appearing between 6 and 12 hours after the injury. These findings indicate that mild hypothermia inhibits neuronal apoptosis following ischemia/reperfusion injury by protecting the mitochondria and that the effective time window is 6-12 hours after ischemia/reperfusion injury.
authors: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China ; Department of Neurology, Guangxi Minzu Hospital, Nanning, Guangxi Zhuang Autonomous Region, China.
authors: Chun
authors: C
authors: Luo
authors: Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China.
authors: Su-Yue
authors: SY
authors: Pan
keywords: Bax; cell apoptosis; ischemia/reperfusion; mild hypothermia; mitochondrial membrane potential; nerve regeneration; neural regeneration; neurons; oxygen-glucose deprivation