title: Pericytes, microvasular dysfunction, and chronic rejection.
abstract: Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention.
authors: 1 The Houston Methodist Research Institute, Houston, TX. 2 CNRS/University Rennes1 UMR 6290, Institute of Genetics and Development of Rennes, Cell Cycle Group, Faculty of Medicine, 35-043 Rennes, France.
authors: Malgorzata
authors: M
authors: Kloc
authors: Jacek Z
authors: JZ
authors: Kubiak
authors: Xian C
authors: XC
authors: Li
authors: Rafik M
authors: RM
authors: Ghobrial
mesh_terms: D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D002450:Cell Communication; D054338:Cell Transdifferentiation; D002908:Chronic Disease; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D005355:Fibrosis; D006084:Graft Rejection / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008833:Microcirculation; D055806:Microvessels / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects*; D020286:Pericytes / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D042501:Angiogenic Proteins; D018836:Inflammation Mediators