title: Mouse brain magnetic resonance microscopy: Applications in Alzheimer disease.
abstract: Over the past two decades, various Alzheimer's disease (AD) trangenetic mice models harboring genes with mutation known to cause familial AD have been created. Today, high-resolution magnetic resonance microscopy (MRM) technology is being widely used in the study of AD mouse models. It has greatly facilitated and advanced our knowledge of AD. In this review, most of the attention is paid to fundamental of MRM, the construction of standard mouse MRM brain template and atlas, the detection of amyloid plaques, following up on brain atrophy and the future applications of MRM in transgenic AD mice. It is believed that future testing of potential drugs in mouse models with MRM will greatly improve the predictability of drug effect in preclinical trials.
authors: Biomedical Engineering Department, College of Life Science and Bioengineering, Beijing University of Technology, Beijing, 100124, China.
authors: Lan
authors: L
authors: Lin
authors: Zhenrong
authors: Z
authors: Fu
authors: Xiaoting
authors: X
authors: Xu
authors: Shuicai
authors: S
authors: Wu
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008822:Mice, Transgenic; D008853:Microscopy / Q000379:methods*; D011859:Radiography
keywords: Alzheimer's disease; MRM; computational neuroanatomy; mouse model