title: Nanopotentiated combination cancer therapy: Chemotherapeutic and chemosensitizer (2C approach).
abstract: An insight into the complex cancer pathophysiology reveals that a dependable amelioration of the disease could only be envisaged with a multipronged treatment approach. It is highly evident that singular chemotherapeutic agents used in clinical practice have shown limitations like severe side effects, MDR and are often associated with poor QOL while combinations of drugs have yielded better therapeutic outcomes. The current hypothesis takes it a step forward wherein a chemotherapeutic agent is combined with a natural chemosensitizer, both loaded into a nanopotentiated particulate system, which would eventually deliver the drug cargo at the target site with certitude. The encapsulated natural bioactive would then favorably act on the tumor milieu through multiple portals and chemosensibilize the cells towards cytotoxic action of the synthetic drug moiety. This 2C (chemotherapeutic and chemosensitizer) approach along with nanosystem's attributes like high payload, prolonged action and diminished side effects would proffer a more dependable treatment modality. In conclusion, the proposed system would be a value addition to the currently available armamentarium of cancer treatment tools.
authors: Dept of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors: Devina
authors: D
authors: Verma
authors: Dept of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors: Tahir
authors: T
authors: Khuroo
authors: Dept of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India.
authors: Sushama
authors: S
authors: Talegaonkar
authors: Dept of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India. Electronic address: ziqbaljh@yahoo.co.in.
authors: Zeenat
authors: Z
authors: Iqbal
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000627:therapeutic use*; D003474:Curcumin / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D004359:Drug Therapy, Combination / Q000379:methods*; D005419:Flavonoids / Q000627:therapeutic use; D005472:Fluorouracil; D006801:Humans; D008954:Models, Biological; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy*; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D013267:Stilbenes; C040015:myricetin; D003474:Curcumin; D000077185:Resveratrol; D005472:Fluorouracil