title: N-Heterocyclic carbene-catalyzed annulation of cyclic β-enamino esters with enals: access to functionalized indolo[2,3-a]quinolizidines.
abstract: A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene (NHC)-catalyzed annulation of cyclic β-enamino esters with enals . This methodology offers a pathway for quick and efficient construction of an indolo[2,3-a]quinolizidine skeleton which is a core structure of many natural products with diverse bioactivities.
authors: State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China. lut163@163.com ddmn9999@cpu.edu.cn.
authors: Shihe
authors: S
authors: Hu
authors: Bingyang
authors: B
authors: Wang
authors: Yu
authors: Y
authors: Zhang
authors: Weifang
authors: W
authors: Tang
authors: Mengyuan
authors: M
authors: Fang
authors: Tao
authors: T
authors: Lu
authors: Ding
authors: D
authors: Du
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004952:Esters / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D054837:Quinolizidines / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D004952:Esters; D006571:Heterocyclic Compounds; D007211:Indoles; D054837:Quinolizidines; D012997:Solvents; C030011:carbene; D002244:Carbon; D008697:Methane