title: Morphological and migratory alterations in retinal Müller cells during early stages of hypoxia and oxidative stress.
abstract: In the present study, retinal Müller cells were cultured in vitro and treated with hydrogen peroxide (oxidative stressor) and cobalt chloride (hypoxic injury). Following 24 hours of culture, compensatory hypertrophy was observed and cellular apoptosis increased. Hypoxia enhanced the migration ability of retinal Müller cells and induced the expression of α-smooth muscle actin. Oxidative stress altered the morphology of Müller cells when compared with hypoxia treatment.
authors: Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an 710004, Shaanxi Province, China.
authors: Xiaohui
authors: X
authors: Zhang
authors: Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an 710004, Shaanxi Province, China.
authors: Zhaohui
authors: Z
authors: Feng
authors: Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an 710004, Shaanxi Province, China.
authors: Chunhua
authors: C
authors: Li
authors: Department of Ophthalmology, Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an 710004, Shaanxi Province, China.
authors: Yuping
authors: Y
authors: Zheng
keywords: Müller cells; glutamine synthetase; hypoxia; migration; neural regeneration; oxidative stress; retina; α-smooth muscle actin