title: Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications.
abstract: The purpose of this study was to assess postural instability in patients with schizophrenia using a pressure-sensitive platform and to examine the effects of anxiety, psychiatric symptoms, and the use of neuroleptic medications on postural sway. Participants were 23 patients with schizophrenia and 23 healthy controls. We found that the patients showed greater overall postural instability than the controls. Furthermore, they demonstrated greater instability when the test was performed with the eyes closed than with the eyes open. However, removal of visual input had less impact on the indices of postural instability in the patients than in the controls, suggesting that schizophrenia is associated with difficulties in integrating visual information and proprioceptive signals. Furthermore, in contrast to the controls, anxiety exacerbated postural instability in the patients. There were significant associations between postural stability and psychiatric symptoms in the patients without extrapyramidal symptoms, whereas medication dose did not significantly correlate with postural stability.
authors: Graduate School of Human Sciences, Osaka University, 1-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Yukako
authors: Y
authors: Matsuura
authors: Graduate School of Human Sciences, Osaka University, 1-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Haruo
authors: H
authors: Fujino
authors: Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan; Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Ryota
authors: R
authors: Hashimoto
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Yuka
authors: Y
authors: Yasuda
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan; Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Hidenaga
authors: H
authors: Yamamori
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Kazutaka
authors: K
authors: Ohi
authors: Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2, Yamadaoka, Suita, Osaka 5650871, Japan.
authors: Masatoshi
authors: M
authors: Takeda
authors: Graduate School of Human Sciences, Osaka University, 1-2, Yamadaoka, Suita, Osaka 5650871, Japan. Electronic address: osamui@hus.osaka-u.ac.jp.
authors: Osamu
authors: O
authors: Imura
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001007:Anxiety / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D004856:Postural Balance / Q000187:drug effects*; D011434:Proprioception / Q000187:drug effects / Q000502:physiology*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents
keywords: Anxiety; Extrapyramidal symptoms; Postural instability; Proprioception; Schizophrenia