title: [Is PON1 a factor of cardiovascular risk in type 2 diabetes?].
abstract: OBJECTIVE
  We evaluate the association between the decrease of serum paraxonase 1 activity and the risk of cardiovascular disease in type 2 diabetes.
  
  
  METHODS
  One hundred and fourteen patients with type 2 diabetes were included in the present study. Seventy-one of them have significant coronary disease. The control group consisted of 53 healthy adults.
  
  
  RESULTS
  PON1 activity was significantly reduced in diabetic patients compared to controls (P=0.021), especially in those with significant coronary disease (P=0.013). No significant variation in PON1 activity according to age was observed both in controls and in patients. When HDLc≥1.03mmol/L, the PON1 activity was significantly higher in patients without significant coronary disease compared to those with significant coronary disease (0.030). In case of significant coronary disease, a decrease of 12.23% in PON1 activity was observed in smokers compared with non-smokers, but without statistical significance. The PON1 activity did not very significantly according to the presence or absence of hypertension in patients with significant coronary disease.
  
  
  CONCLUSIONS
  The implication of diabetes in the decrease of PON1 activity seems highly probable but PON1 activity seems not to be in itself a marker of cardiovascular disease.
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie. Electronic address: triki_sony@yahoo.fr.
authors: S
authors: S
authors: Triki
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: O
authors: O
authors: Fekih
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: I
authors: I
authors: Hellara
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: F
authors: F
authors: Neffati
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: W
authors: W
authors: Douki
authors: Department of cardiology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: K
authors: K
authors: Ben Hamda
authors: Department of cardiology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: F
authors: F
authors: Maatouk
authors: Department of biochemistry, toxicology, Fattouma Bourguiba university hospital, Monastir, Tunisie.
authors: M F
authors: MF
authors: Najjar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D043303:Aryldialkylphosphatase
keywords: Cardivascular disease; Diabetes; Diabète type 2; PON1; Risque cardiovasculaire