title: Living donor bone banking: processing and discarding--from procurement to therapeutic use.
abstract: Skeletal muscle and osteoarticular tissue banks are responsible to procure, process, store and distribute tissues, from living and cadaveric donors. The procedures involve the application of protocols covering all aspects of the banking, ensuring the best tissue quality and maximum safety for the recipient. An analysis on the causes of bone tissue discarded by Biotar Tissue Bank between January 2005 and December 2012 was carried. Bone tissue was obtained from both hip and knee replacement (femoral heads and tibial plateau respectively) in living donors treated at different medical-surgical institutions in Argentina. These tissues were processed at the Bank to produce both frozen and lyophilized cancellous bone. Out of 3413 donated bones received by the Bank, 77.55 % resulted in final product, while the remaining 22.44 % was discarded in compliance with the quality standards of both the Bank and the regulatory authority. Comparing the last and the first year of the studied period, the number of discarded tissue increased 3.6 times, while the number of collected bones was approximately 10 times higher. Related to total disposed tissue, reactive serology was the most frequent cause (62.14 %), followed by inappropriate collection/storage of blood sample (30.81 %). A progressive reduction in the percentages of total discard was observed, and this was proportional to inappropriate collection/storage of blood sample. No significant differences were found in the discard rates due to positive serology throughout all the years studied. The success of a tissue bank requires full commitment of all the personnel especially the team members responsible for donor selection and the processing of allografts. It is important to critically screen donors in the early stages of donor recruitment. All of the procedures carried out by the tissue bank are parts of the quality control system which must be strictly carried out. Biotar Tissue Bank is continuously committed to ensure safety to the recipients.
authors: , Rosario, Santa Fe, Argentina.
authors: Paula
authors: P
authors: Hovanyecz
authors: , Rosario, Santa Fe, Argentina. alicia.lorenti@gmail.com.
authors: Alicia
authors: A
authors: Lorenti
authors: , Rosario, Santa Fe, Argentina.
authors: José Manuel Juan
authors: JM
authors: Lucero
authors: , Rosario, Santa Fe, Argentina.
authors: Adrián
authors: A
authors: Gorla
authors: , Rosario, Santa Fe, Argentina.
authors: Alejandro Enrique
authors: AE
authors: Castiglioni
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina; D018586:Bone Banks / Q000706:statistics & numerical data*; D016025:Bone Transplantation / Q000706:statistics & numerical data*; D046148:Donor Selection / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000706:statistics & numerical data; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Biosafety; Bone allografts; Femoral head banking; Living donors