title: Effects of lateral ventricular transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene on cognition in a rat model of Alzheimer's disease.
abstract: In the present study, transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene into the lateral ventricle of a rat model of Alzheimer's disease, resulted in significant attenuation of nerve cell damage in the hippocampal CA1 region. Furthermore, brain-derived neurotrophic factor and tyrosine kinase B mRNA and protein levels were significantly increased, and learning and memory were significantly improved. Results indicate that transplantation of bone marrow-derived mesenchymal stem cells modified with brain-derived neurotrophic factor gene can significantly improve cognitive function in a rat model of Alzheimer's disease, possibly by increasing the levels of brain-derived neurotrophic factor and tyrosine kinase B in the hippocampus.
authors: Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China.
authors: Ping
authors: P
authors: Zhang
authors: Research Center for Bioengineering Technology, Hebei University, Baoding 071000, Hebei Province, China.
authors: Gangyong
authors: G
authors: Zhao
authors: College of Life Science, Hebei University, Baoding 071000, Hebei Province, China.
authors: Xianjiang
authors: X
authors: Kang
authors: Department of Neurology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China.
authors: Likai
authors: L
authors: Su
keywords: Alzheimer's disease; bone marrow-derived mesenchymal stem cells; brain-derived neurotrophic factor; electrotransfection; lateral ventricle; neural regeneration