title: Phenolic diterpenoid derivatives as anti-influenza a virus agents.
abstract: A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.
authors: Surgical Science, Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States.
authors: Zhao
authors: Z
authors: Dang
authors: Surgical Science, Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States.
authors: Katherine
authors: K
authors: Jung
authors: Surgical Science, Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States.
authors: Lei
authors: L
authors: Zhu
authors: School of Dentistry, Meharry Medical College , Nashville, Tennessee 37208, United States.
authors: Hua
authors: H
authors: Xie
authors: Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina , Chapel Hill, North Carolina 27599, United States ; Chinese Medicine Research and Development Center, China Medical University and Hospital , Taichung, Taiwan.
authors: Kuo-Hsiung
authors: KH
authors: Lee
authors: Surgical Science, Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States.
authors: Chin-Ho
authors: CH
authors: Chen
authors: Surgical Science, Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States.
authors: Li
authors: L
authors: Huang
keywords: Influenza A; hemagglutinin; influenza inhibitor; podocarpic acid; totarol