title: Copper-mediated radical 1,2-bis(trifluoromethylation) of alkenes with sodium trifluoromethanesulfinate.
abstract: An efficient chemoselective 1,2-bis(trifluoromethylation) of alkenes with CF3SO2Na promoted by t-BuOOH/CuCl was developed. This protocol provided the first convenient preparation of 1,2-bis(trifluoromethylated) compounds by the vicinal difunctionalization of alkenes. The chemoselectivity of this reaction was accomplished by increasing the concentration of the CF3 radical.
authors: †Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China.
authors: Bin
authors: B
authors: Yang
authors: †Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China.
authors: Xiu-Hua
authors: XH
authors: Xu
authors: †Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China.|‡College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Lu, Shanghai 201620, China.
authors: Feng-Ling
authors: FL
authors: Qing
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000475:Alkenes; D005609:Free Radicals; D006845:Hydrocarbons, Fluorinated; D008698:Mesylates; C000592252:sodium trifluoromethanesulfinate; D003300:Copper