title: The relationship between CSE1L expression and axillary lymph node metastasis in breast cancer.
abstract: OBJECTIVE
  CSE1L is the human homologue to the yeast gene CSE1 and CSE1L is a gene related to cancer progression. Thus, CSE1L may regulate the invasion and metastasis of breast cancer. The aim of this study is to show the relationship between CSE1L and axillary lymph node metastasis.
  
  
  METHODS
  Sixty-six breast cancer patients were evaluated according to patient and tumor characteristics. Immunohistochemistry was carried out on formalin-fixed, paraffin-embedded archival breast tumor tissues. The results of CSE1L staining were analyzed according to the percentage of immunoreactive cells.
  
  
  RESULTS
  There were 29 patients without axillary lymph node metastasis and 37 patients with nodal metastasis. The mean age of the patients was 50.6 ± 11.3 years. Age, tumor size, nuclear grade and hormone receptor status were similar in the axillary lymph node positive and negative groups. There was a statistically significant relationship between cytoplasmic CSE1L expression and axillary lymph node metastasis. However, nuclear CSE1L expression did not have any effect on axillary lymph node metastasis.
  
  
  CONCLUSIONS
  Cytoplasmic CSE1L overexpression may be a valuable tool for prognosis of breast cancer in future.
authors: Department of Surgery, Oncology Training and Research Hospital, Ankara - Turkey.
authors: Ulvi Murat
authors: UM
authors: Yuksel
authors: Gulay
authors: G
authors: Dilek
authors: Lutfi
authors: L
authors: Dogan
authors: Mehmet Ali
authors: MA
authors: Gulcelik
authors: Ugur
authors: U
authors: Berberoglu
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology*; D029563:Cellular Apoptosis Susceptibility Protein / Q000032:analysis*; D003593:Cytoplasm / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D029563:Cellular Apoptosis Susceptibility Protein