title: Impact of osteoporosis in dental implants: A systematic review.
abstract: OBJECTIVE
  To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects.
  
  
  METHODS
  Extensive examination strategies were created to classify studies for this systematic review. MEDLINE (via PubMed) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeSH words described as follow: "osteoporosis" or "osteopenia" or "estrogen deficiency" AND "implant" or "dental implant" or "osseointegration". Assessment of clinical and/or histological peri-implant conditions in osteoporosis subjects treated with titanium dental implants. The examination included a combination of the MeSH terms described as follow: "osteoporosis" or "osteopenia" or "estrogen deficiency" AND "implant" or "dental implant" or "osseointegration".
  
  
  RESULTS
  Of 943 potentially eligible articles, 12 were included in the study. A total of 133 subjects with osteoporosis, 73 subjects diagnosed with osteopenia and 708 healthy subjects were assessed in this systematic review. In these subjects were installed 367, 205, 2981 dental implants in osteoporotic, osteopenic and healthy subjects, respectively. The failure rate of dental implant was 10.9% in osteoporotic subjects, 8.29% in osteopenic and 11.43% in healthy ones. Bone-to-implant contact obtained from retrieved implants ranged between 49.96% to 47.84%, for osteoporosis and non-osteoporotic subjects.
  
  
  CONCLUSIONS
  Osteoporotic subjects presented higher rates of implant loss, however, there is a lower evidence to strengthen or refute the hypothesis that osteoporosis may have detrimental effects on bone healing. Consequently, final conclusions regarding the effect of osteoporosis in dental implant therapy cannot be made at this time. There are no randomized clinical trial accessible for evaluation and the retrospective nature of the evaluated studies shall be taken in account when interpreting this study.
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Gabriela
authors: G
authors: Giro
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Leandro
authors: L
authors: Chambrone
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Abrao
authors: A
authors: Goldstein
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Jose Augusto
authors: JA
authors: Rodrigues
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Elton
authors: E
authors: Zenóbio
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Magda
authors: M
authors: Feres
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Luciene Cristina
authors: LC
authors: Figueiredo
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Alessandra
authors: A
authors: Cassoni
authors: Gabriela Giro, Leandro Chambrone, Abrao Goldstein, Jose Augusto Rodrigues, Elton Zenóbio, Magda Feres, Luciene Cristina Figueiredo, Alessandra Cassoni, Jamil Awad Shibli, Department of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, Guarulhos SP 07023-040, Brazil.
authors: Jamil Awad
authors: JA
authors: Shibli
keywords: Dental implants; Failures; Osseointegration; Osteopenia; Osteoporosis