title: A Signal-Passing DNA-Strand-Exchange Mechanism for Active Self-Assembly of DNA Nanostructures.
abstract: DNA nanostructured tiles play an active role in their own self-assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self-assembly of tiles and enables local communication during the self-assembly process. This localized signal-passing mechanism provides a new element of control for autonomous self-assembly of DNA nanostructures.
authors: Department of Chemistry, New York University, New York, NY 10003 (USA); Current Address: Department of Materials Science and Engineering, Boise State University, Boise, ID 83725 (USA). jenniferepadilla@boisestate.edu.
authors: Jennifer E
authors: JE
authors: Padilla
authors: Ruojie
authors: R
authors: Sha
authors: Martin
authors: M
authors: Kristiansen
authors: Junghuei
authors: J
authors: Chen
authors: Natasha
authors: N
authors: Jonoska
authors: Nadrian C
authors: NC
authors: Seeman
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*
chemical_list: D004247:DNA
keywords: DNA structures; DNA tiles; nanotechnology; self-assembly; strand displacement