title: Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid on Wound Healing.
abstract: We examined the in vivo efficacy of ultra-high molecular weight poly-γ-glutamic acid (UHMW γ-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW γ-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW γ-PGAtreated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW γ-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW γ-PGA-treated groups. Increased levels of transforming growth factor-beta and β-catenin were also observed in skin samples collected from UHMW γ-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW γ-PGA promotes wound healing in vivo.
authors: BioLeaders Corporation, Daejeon 305-500, Republic of Korea.|Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 136-702, Republic of Korea.
authors: Jae-Chul
authors: JC
authors: Choi
authors: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita 565-0871, Japan.
authors: Hiroshi
authors: H
authors: Uyama
authors: Department of Pharmacy, College of Pharmacy, Hanyang University, Kyeonggi-do 426-791, Republic of Korea.
authors: Chul-Hoon
authors: CH
authors: Lee
authors: BioLeaders Corporation, Daejeon 305-500, Republic of Korea.|Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 136-702, Republic of Korea.
authors: Moon-Hee
authors: MH
authors: Sung
mesh_terms: D000818:Animals; D001699:Biometry; D003879:Dermatologic Agents / Q000737:chemistry / Q000494:pharmacology*; D008970:Molecular Weight; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000033:anatomy & histology / Q000293:injuries; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003879:Dermatologic Agents; C511775:poly(gamma-glutamic acid); D011099:Polyglutamic Acid