title: Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery.
abstract: A chimeric aptamer-DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.
authors: Department of Nanobiotechnology, Vision Research Foundation, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Chennai, India. drkrishnakumar_2000@yahoo.com.
authors: Nithya
authors: N
authors: Subramanian
authors: Jagat R
authors: JR
authors: Kanwar
authors: Balachandran
authors: B
authors: Akilandeswari
authors: Rupinder K
authors: RK
authors: Kanwar
authors: Vikas
authors: V
authors: Khetan
authors: Subramanian
authors: S
authors: Krishnakumar
mesh_terms: D052157:Aptamers, Nucleotide / Q000378:metabolism*; D045744:Cell Line, Tumor; D021881:DNA, Catalytic / Q000378:metabolism*; D004337:Drug Carriers / Q000378:metabolism*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000378:metabolism*; D000077022:Survivin; D000097796:Nucleolin
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D004337:Drug Carriers; D051034:Inhibitor of Apoptosis Proteins; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D000077022:Survivin; D000097796:Nucleolin; C107489:BIRC5 protein, human