title: The electrical interplay between proteins and lipids in membranes.
abstract: All molecular interactions that are relevant to cellular and molecular structures are electrical in nature but manifest in a rich variety of forms that each has its own range and influences on the net effect of how molecular species interact. This article outlines how electrical interactions between the protein and lipid membrane components underlie many of the activities of membrane function. Particular emphasis is placed on spatially localised behaviour in membranes involving modulation of protein activity and microdomain structure. The interactions between membrane lipids and membrane proteins together with their role within cell biology represent an enormous body of work. Broad conclusions are not easy given the complexities of the various systems and even consensus with model membrane systems containing two or three lipid types is difficult. By defining two types of broad lipid-protein interaction, respectively Type I as specific and Type II as more non-specific and focussing on the electrical interactions mostly in the extra-membrane regions it is possible to assemble broad rules or a consensus of the dominant features of the interplay between these two fundamentally important classes of membrane component. This article is part of a special issue entitled: Lipid-protein interactions.
authors: Cell Biophysics Group, Institute of Biophysics, Imaging and Optical Science, School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
authors: Joanna L
authors: JL
authors: Richens
authors: Cell Biophysics Group, Institute of Biophysics, Imaging and Optical Science, School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
authors: Jordan S
authors: JS
authors: Lane
authors: Cell Biophysics Group, Institute of Biophysics, Imaging and Optical Science, School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
authors: Jonathan P
authors: JP
authors: Bramble
authors: Cell Biophysics Group, Institute of Biophysics, Imaging and Optical Science, School of Life Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Electronic address: paul.oshea@nottingham.ac.uk.
authors: Paul
authors: P
authors: O'Shea
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D004553:Electric Conductivity; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins
keywords: DLVO theory; Membrane dipole potential; Membrane electrostatic surface potential; Membrane functional imaging; Membrane microdomain; Potential of mean force