title: The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
abstract: The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures during this critical period. Key exposure domains include indoor and outdoor air pollutants, inhalation, ingestion and dermal uptake of chemicals, mold, dampness, biological allergens, pets and pests, housing structure, and living behavior, together with infections, nutrition, psychosocial environment, and medications. Assessments of early life exposures are focused on those linked to inflammatory responses driven by the acquired and innate immune systems. Mothers complete extensive environmental questionnaires including time-activity behavior at recruitment and when the child is 3, 6, 12, 24, 30, 36, 48, and 60 months old. House dust collected during a thorough home assessment at 3-4 months, and biological specimens obtained for multiple exposure-related measurements, are archived for analyses. Geo-locations of homes and daycares and land-use regression for estimating traffic-related air pollution complement time-activity-behavior data to provide comprehensive individual exposure profiles. Several analytical frameworks are proposed to address the many interacting exposure variables and potential issues of co-linearity in this complex data set.
authors: Simon Fraser University, Vancouver, British Columbia, Canada.
authors: Tim K
authors: TK
authors: Takaro
authors: University of Toronto, Toronto, Ontario, Canada.
authors: James A
authors: JA
authors: Scott
authors: Simon Fraser University, Vancouver, British Columbia, Canada.
authors: Ryan W
authors: RW
authors: Allen
authors: McMaster University, Hamilton, Ontario, Canada.
authors: Sonia S
authors: SS
authors: Anand
authors: University of Manitoba, Winnipeg, Manitoba, Canada.
authors: Allan B
authors: AB
authors: Becker
authors: University of Alberta, Edmonton, Alberta, Canada.
authors: A Dean
authors: AD
authors: Befus
authors: University of British Columbia, Vancouver, British Columbia, Canada.
authors: Michael
authors: M
authors: Brauer
authors: McMaster University, Hamilton, Ontario, Canada.
authors: Joanne
authors: J
authors: Duncan
authors: McMaster University, Hamilton, Ontario, Canada.
authors: Diana L
authors: DL
authors: Lefebvre
authors: University of Toronto, Toronto, Ontario, Canada.
authors: Wendy
authors: W
authors: Lou
authors: University of Alberta, Edmonton, Alberta, Canada.
authors: Piush J
authors: PJ
authors: Mandhane
authors: Simon Fraser University, Vancouver, British Columbia, Canada.
authors: Kathleen E
authors: KE
authors: McLean
authors: Northwestern University, Evanston, Illinois, USA.
authors: Gregory
authors: G
authors: Miller
authors: University of British Columbia, Vancouver, British Columbia, Canada.
authors: Hind
authors: H
authors: Sbihi
authors: Simon Fraser University, Vancouver, British Columbia, Canada.|Karlstad University, Karlstad, Värmland, Sweden.
authors: Huan
authors: H
authors: Shu
authors: University of Toronto, Toronto, Ontario, Canada.|Hospital for Sick Children, Toronto, Ontario, Canada.
authors: Padmaja
authors: P
authors: Subbarao
authors: University of British Columbia, Vancouver, British Columbia, Canada.
authors: Stuart E
authors: SE
authors: Turvey
authors: Edith Cowan University, Joondalup, Western Australia, Australia.|Health Canada, Ottawa, Ontario, Canada.
authors: Amanda J
authors: AJ
authors: Wheeler
authors: University of Waterloo, Waterloo, Ontario, Canada.
authors: Leilei
authors: L
authors: Zeng
authors: McMaster University, Hamilton, Ontario, Canada.
authors: Malcolm R
authors: MR
authors: Sears
authors: University of Toronto, Toronto, Ontario, Canada.|Environment Canada, Toronto, Ontario, Canada.
authors: Jeffrey R
authors: JR
authors: Brook
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects / Q000032:analysis; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis; D000818:Animals; D002170:Canada; D002657:Child Development / Q000187:drug effects*; D002675:Child, Preschool; D003296:Cooking; D004391:Dust / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D005430:Floors and Floorcoverings; D006801:Humans; D007223:Infant; D007374:Interior Design and Furnishings; D008137:Longitudinal Studies; D057805:Pets; D011446:Prospective Studies; D011795:Surveys and Questionnaires
chemical_list: D000393:Air Pollutants; D004391:Dust