title: Aggregation and environmental transmission in Chronic Wasting Disease.
abstract: Disease transmission depends on the interplay between the infectious agent and the behavior of the host. Some diseases, such as Chronic Wasting Disease, can be transmitted directly between hosts as well as indirectly via the environment. The social behavior of hosts affects both of these pathways, and a successful intervention requires knowledge of the relative influence of the different etiological and behavioral aspects of the disease. We develop a strategic differential equation model for Chronic Wasting Disease and include direct and indirect transmission as well as host aggregation into our model. We calculate the basic reproduction number and perform a sensitivity analysis based on Latin hypercube sampling from published parameter values. We find conditions for the existence of an endemic equilibrium, and show that, under a certain mild assumption on parameters, the model does not exhibit a backward bifurcation or bistability. Hence, the basic reproduction number constitutes the disease elimination threshold. We find that the prevalence of the disease decreases with host aggregation and increases with the lifespan of the infectious agent in the environment.
authors: Department of Mathematics, Christopher Newport University, 1 Avenue of the Arts, Newport News, VA 23606, United States. olga.vasilyeva@cnu.edu.
authors: Olga
authors: O
authors: Vasilyeva
authors: Tamer
authors: T
authors: Oraby
authors: Frithjof
authors: F
authors: Lutscher
mesh_terms: D000465:Algorithms; D000818:Animals; D050936:Basic Reproduction Number; D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D003198:Computer Simulation; D003670:Deer; D004777:Environment; D008962:Models, Theoretical; D011157:Population Dynamics; D017096:Prion Diseases / Q000453:epidemiology; D034081:Wasting Disease, Chronic / Q000453:epidemiology* / Q000635:transmission