title: Development and evaluation of a live attenuated camelpox vaccine from a local field isolate of the virus.
abstract: A strain of camelpox virus (CMLV) isolated in the Sudan was attenuated by serial passage in Vero cell monolayers for use as a future vaccine strain. The safety and potency of passage 115 virus (designated Sudan CMLV/115) was tested. Camels inoculated with CMLV/115 showed no clinical disease or skin lesions, developed low-level antibodies and cell-mediated immune response and resisted challenge with virulent wild-type CMLV. Field testing of the candidate vaccine showed that the developed vaccine induces immune response and is safe for young and pregnant camels.
authors: Department of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Shambat, P.O. Box 32, Khartoum North, Sudan|Department of Microbiology, Faculty of Veterinary Science, University of Nyala, P.O. Box 155, Nyala, Sudan
authors: M M
authors: MM
authors: Abdellatif
authors: Department of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Shambat, P.O. Box 32, Khartoum North, Sudan
authors: A A
authors: AA
authors: Ibrahim
authors: Department of Microbiology, Faculty of Veterinary Medicine, University of Khartoum, Shambat, P.O. Box 32, Khartoum North, Sudan
authors: A I
authors: AI
authors: Khalafalla
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D008297:Male; D018155:Orthopoxvirus / Q000276:immunology*; D011213:Poxviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D011247:Pregnancy; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
keywords: Camelpox; Camelpox virus; Cell culture attenuation; Vaccine; Vaccine evaluation