title: [Ecotoxicological effects of chlorotetracycline on earthworm in soil].
abstract: Eiseniafoetida was selected to investigate the ecotoxicological effects of chlorotetracycline on the earthworm in soil. The results showed that 1, 10 and 100 mg · kg(-1) chlorotetracycline had no significant effects on earthworm's body mass after a 7-d exposure, but it was significantly inhibited by 10, 100 mg · kg(-1) chlorotetracycline after 21 days. The soluble protein content of earthworm was induced by 1, 10 and 100 mg · kg(-1) chlorotetracycline, and showed a positive response as the con- centration increased. Also, the earthworm treated by 1, 10 and 100 mg · kg(-1) chlorotetracycline induced the increases of SOD, POD and CAT activities to different degrees. The gene expression in earthworm changed significantly after a 28-d exposure. It is suggested that chlorotetracycline had a chronic ecotoxicological effect on earthworm, and the body mass, soluble protein, antioxidant en- zyme and gene expression could be used as the biomarkers to estimate chlorotetracycline toxicity.
authors: Zhan-Hua
authors: ZH
authors: Ji
authors: Jing
authors: J
authors: An
authors: Ming-Yue
authors: MY
authors: Xiao
authors: Shu-He
authors: SH
authors: Wei
authors: Pei-Dong
authors: PD
authors: Tai
authors: Ze
authors: Z
authors: Lu
mesh_terms: D000818:Animals; D015415:Biomarkers; D002751:Chlortetracycline / Q000633:toxicity*; D054750:Ecotoxicology; D009835:Oligochaeta / Q000187:drug effects*; D012987:Soil; D012989:Soil Pollutants / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D012987:Soil; D012989:Soil Pollutants; D002751:Chlortetracycline