title: Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease.
abstract: Traditional dogma regarding the brain as an immune exempt organ has changed in recent years. New research has highlighted the role of the classical complement cascade in both synaptic elimination and function, driven largely by the role of the pathway initiating protein C1q. Given the links between C1q and cognitive function we assessed the genetic variability of the C1q encoding genes: C1QA, C1QB and C1QC between PD patients and matched controls. Despite a strong link between C1Q/cognitive decline and PD/cognitive decline we were unable to find a link between common C1Q variation and PD. We conclude that common C1Q-A/B/C genetic variation is unlikely to contribute to cognitive decline or the missing heritability in PD.
authors: Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom.
authors: Sophia
authors: S
authors: Carbutt
authors: Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom.
authors: Jennifer
authors: J
authors: Duff
authors: Institute for Ageing and Health, University of Newcastle Upon Tyne, United Kingdom.
authors: Alison
authors: A
authors: Yarnall
authors: Institute for Ageing and Health, University of Newcastle Upon Tyne, United Kingdom.
authors: David J
authors: DJ
authors: Burn
authors: Mitochondrial Research Group, University of Newcastle Upon Tyne, United Kingdom. Electronic address: Gavin.Hudson@ncl.ac.uk.
authors: Gavin
authors: G
authors: Hudson
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000235:genetics*; D015922:Complement C1q / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000523:psychology
chemical_list: D015922:Complement C1q
keywords: Cognitive decline; Parkinson’s disease