title: Role of dexmedetomidine in early extubation of the intensive care unit patients.
abstract: OBJECTIVE
  Patients on ventilatory support in intensive care unit (ICU) require sedation and analgesia to facilitate mechanical ventilation and endotracheal tube tolerance. The selection of the agent should be such that it does not interfere with the early extubation of the patients. We compared the efficacy of dexmedetomidine with midazolam to facilitate extubation of patients from mechanical ventilation in terms of the sedative properties, cardiovascular responses, ventilation, and extubation characteristics and safety profile.
  
  
  METHODS
  A total of 40 adult, mechanically ventilated patients of either sex, aged 18-60 years, meeting the standard criteria for weaning, randomized into 2 groups of 20 patients each, received intravenous infusion of dexmedetomidine (0.2-0.7 mcg/kg/h) or midazolam (0.04-0.2 mg/kg/h) as needed for Ramsay sedation scale 2-4. Extubation following standard extubation protocol was done. Time for extubation and vital parameters were regularly recorded.
  
  
  RESULTS
  The time to extubation in the dexmedetomidine group was significantly lower than in the midazolam group. Heart rate and blood pressure was significantly lower in dexmedetomidine group than the midazolam group at most of the times.
  
  
  CONCLUSIONS
  Dexmedetomidine has clinically relevant benefits compared with midazolam in facilitating extubation due to its shorter time to extubation, more hemodynamic stability, easy arousability, and lack of respiratory depression.
authors: Department of Anaesthesiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors: Shikha
authors: S
authors: Gupta
authors: Department of Anaesthesiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors: Dupinder
authors: D
authors: Singh
authors: Department of Anaesthesiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors: Dinesh
authors: D
authors: Sood
authors: Department of Anaesthesiology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors: Suneet
authors: S
authors: Kathuria
keywords: Dexmedetomidine; extubation; intensive care unit; midazolam; sedation