title: Interactions between plasma homocysteine and arterial stiffness in chronic kidney disease in community-dwelling individuals: The Maine-Syracuse Study.
abstract: Plasma homocysteine (tHcy) is associated with kidney disease. However, few, if any, studies have examined homocysteine in relation to arterial stiffness, with stratification by the presence or absence of early-stage chronic kidney disease (CKD). The aim of this study was to examine prospective associations between tHcy and carotid-femoral pulse wave velocity (PWV) in persons with and without early-stage CKD in a sample of community-living individuals free from end-stage renal disease, dialysis, stroke and dementia. We conducted a prospective study with 498 participants of the Maine-Syracuse Longitudinal Study (mean age 61 years). Levels of tHcy were positively related to PWV measured 4-5 years later for participants with early-stage CKD (estimated glomerular filtration rate <60 ml min(-1) per 1.73 m(2)). Statistical adjustment was made for multiple confounders, including demographic factors, PWV-related variables and cardiovascular risk factors (b=4.27, 95% confidence interval: 0.23-8.31, P=0.04). These associations were not observed in persons free from CKD. Plasma tHcy is an important predictor of arterial stiffness, as indexed by PWV, in community-living individuals with modest CKD.
authors: Department of Psychology, University of Maine, Orono, ME, USA.|Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA.
authors: M F
authors: MF
authors: Elias
authors: Nutritional Physiology Research Centre, University of South Australia, Adelaide, SA, Australia.|Centre de Recherche Public Santé, Centre d'Etudes en Santé, Grand-Duchy of Luxembourg, Luxembourg.
authors: G E
authors: GE
authors: Crichton
authors: College of Medicine, Biology, and Environment, Australian National University, Canberra, ACT, Australia.
authors: W P
authors: WP
authors: Abhayaratna
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000503:physiopathology*; D059289:Vascular Stiffness
chemical_list: D006710:Homocysteine