title: Determination of HLA-A, -C, -B, -DRB1 allele and haplotype frequency in Japanese population based on family study.
abstract: The present study investigates the human leucocyte antigen (HLA) allele and haplotype frequencies in Japanese population. We carried out the frequency analysis in 5824 families living across Japanese archipelago. The studied population has mainly been typed for the purpose of transplant, especially the hematopoietic stem cell transplantation (HSCT). We determined HLA class I (A, B, and C) and HLA class II (DRB1) using Luminex technology. The haplotypes were directly counted by segregation. A total of 44 HLA-A, 29 HLA-C, 75 HLA-B, and 42 HLA-DRB1 alleles were identified. In the HLA haplotypes of A-C-B-DRB1 and C-B, the pattern of linkage disequilibrium peculiar to Japanese population has been confirmed. Moreover, the haplotype frequencies based on family study was compared with the frequencies estimated by maximum likelihood estimation (MLE), and the equivalent results were obtained. The allele and haplotype frequencies obtained in this study could be useful for anthropology, transplantation therapy, and disease association studies.
authors: HLA Foundation Laboratory, Kyoto, Japan.
authors: N
authors: N
authors: Ikeda
authors: H
authors: H
authors: Kojima
authors: M
authors: M
authors: Nishikawa
authors: K
authors: K
authors: Hayashi
authors: T
authors: T
authors: Futagami
authors: T
authors: T
authors: Tsujino
authors: Y
authors: Y
authors: Kusunoki
authors: N
authors: N
authors: Fujii
authors: S
authors: S
authors: Suegami
authors: Y
authors: Y
authors: Miyazaki
authors: D
authors: D
authors: Middleton
authors: H
authors: H
authors: Tanaka
authors: H
authors: H
authors: Saji
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D002648:Child; D005190:Family; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008297:Male; D010375:Pedigree; D014019:Tissue Donors
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D059811:HLA-DRB1 Chains
keywords: Japanese population; allele frequency; family study; haplotype frequency; human leucocyte antigen