title: Dual-time-point O-(2-[(18)F]fluoroethyl)-L-tyrosine PET for grading of cerebral gliomas.
abstract: OBJECTIVE
  We aimed to evaluate the diagnostic potential of dual-time-point imaging with positron emission tomography (PET) using O-(2-[(18)F]fluoroethyl)-L-tyrosine ((18)F-FET) for non-invasive grading of cerebral gliomas compared with a dynamic approach.
  
  
  METHODS
  Thirty-six patients with histologically confirmed cerebral gliomas (21 primary, 15 recurrent; 24 high-grade, 12 low-grade) underwent dynamic PET from 0 to 50 min post-injection (p.i.) of (18)F-FET, and additionally from 70 to 90 min p.i. Mean tumour-to-brain ratios (TBRmean) of (18)F-FET uptake were determined in early (20-40 min p.i.) and late (70-90 min p.i.) examinations. Time-activity curves (TAC) of the tumours from 0 to 50 min after injection were assigned to different patterns. The diagnostic accuracy of changes of (18)F-FET uptake between early and late examinations for tumour grading was compared to that of curve pattern analysis from 0 to 50 min p.i. of (18)F-FET.
  
  
  RESULTS
  The diagnostic accuracy of changes of the TBRmean of (18)F-FET PET uptake between early and late examinations for the identification of HGG was 81% (sensitivity 83%; specificity 75%; cutoff - 8%; p < 0.001), and 83% for curve pattern analysis (sensitivity 88%; specificity 75%; p < 0.001).
  
  
  CONCLUSIONS
  Dual-time-point imaging of (18)F-FET uptake in gliomas achieves diagnostic accuracy for tumour grading that is similar to the more time-consuming dynamic data acquisition protocol.
  
  
  CONCLUSIONS
  • Dual-time-point imaging is equivalent to dynamic FET PET for grading of gliomas. • Dual-time-point imaging is less time consuming than dynamic FET PET. • Costs can be reduced due to higher patient throughput. • Reduced imaging time increases patient comfort and sedation might be avoided. • Quicker image interpretation is possible, as no curve evaluation is necessary.
authors: Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Wilhelm-Johnen-Str., Jülich, 52428, Germany.
authors: Philipp
authors: P
authors: Lohmann
authors: Hans
authors: H
authors: Herzog
authors: Elena
authors: E
authors: Rota Kops
authors: Gabriele
authors: G
authors: Stoffels
authors: Natalie
authors: N
authors: Judov
authors: Christian
authors: C
authors: Filss
authors: Norbert
authors: N
authors: Galldiks
authors: Lutz
authors: L
authors: Tellmann
authors: Carolin
authors: C
authors: Weiss
authors: Michael
authors: M
authors: Sabel
authors: Heinz Hubert
authors: HH
authors: Coenen
authors: Nadim Jon
authors: NJ
authors: Shah
authors: Karl-Josef
authors: KJ
authors: Langen
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D005910:Glioma / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010808:Physical Examination; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014443:Tyrosine / Q000031:analogs & derivatives*
chemical_list: C117289:O-(2-fluoroethyl)tyrosine; D019275:Radiopharmaceuticals; D014443:Tyrosine