title: [Genetic factors in pathogenesis, course and treatment of inflammatory bowel diseases].
abstract: Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal disorders with alternating relapses and remissions. Two main types within IBD can be distinguished: Crohn's disease and ulcerative colitis. Considering the epidemiological, immunological and genetic data, it was concluded that IBD possess multifactorial etiology, where genetic and environmental factors form the immunological background for the disease. In this review we discuss the most important genes and their protein products in IBD etiology and their impact on IBD pharmacotherapy.
authors: Zakład Biochemii, Wydział Lekarski, Uniwersytet Medyczny w Łodzi.
authors: Hubert
authors: H
authors: Zatorski
authors: Zakład Biochemii, Wydział Lekarski, Uniwersytet Medyczny w Łodzi.
authors: Maciej
authors: M
authors: Sałaga
authors: Zakład Biochemii, Wydział Lekarski, Uniwersytet Medyczny w Łodzi.
authors: Marta
authors: M
authors: Zielińska
authors: Zakład Biochemii, Wydział Lekarski, Uniwersytet Medyczny w Łodzi.
authors: Jakub
authors: J
authors: Fichna
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D003424:Crohn Disease / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged