title: Copper-catalyzed trifluoromethylation of trisubstituted allylic and homoallylic alcohols.
abstract: An efficient copper-catalyzed trifluoromethylation of trisubstituted allylic and homoallylic alcohols with Togni's reagent has been developed. This strategy, accompanied by a double-bond migration, leads to various branched CF3-substituted alcohols by using readily available trisubstituted cyclic/acyclic alcohols as substrates. Moreover, for alcohols in which β-H elimination is prohibited, CF3-containing oxetanes are isolated as the sole product.
authors: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Guangzhou 510530 (P. R. China).
authors: Jian
authors: J
authors: Lei
authors: Xiaowu
authors: X
authors: Liu
authors: Shaolin
authors: S
authors: Zhang
authors: Shuang
authors: S
authors: Jiang
authors: Minhao
authors: M
authors: Huang
authors: Xiaoxing
authors: X
authors: Wu
authors: Qiang
authors: Q
authors: Zhu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D005617:Chlorofluorocarbons, Methane / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D005617:Chlorofluorocarbons, Methane; D004988:Ethers, Cyclic; D006571:Heterocyclic Compounds; D020005:Propanols; C006463:allyl alcohol; D003300:Copper; C009554:fluoroform
keywords: (homo)allylic alcohols; branched products; copper; radical reactions; trifluoromethylation