title: Serum omentin levels in adolescent girls with anorexia nervosa and obesity.
abstract: It is believed that omentin is secreted by stromal cells of adipose tissue and modulates insulin sensitivity. Data from a few studies have shown lower serum omentin in obese children and higher in anorexia nervosa. However, to date, there is lack of research on serum omentin concentrations in adolescent patients in a wide range of body mass index (BMI) and insulin resistance. In this cross-sectional study omentin-1 serum concentrations were evaluated using commercially available ELISA kit in 47 Polish girls with restrictive anorexia nervosa (AN), 50 with simple obesity (OB) and 39 healthy controls (C). The mean serum omentin-1 concentration in girls with AN was statistically significantly higher than that of C and OB girls. Statistically significant (P<0.0001) negative correlations between the serum concentrations of omentin-1 and body weight (r=-0.73), BMI (r=-0.75), standard deviation score for body mass index (BMI-SDS) (r=-0.75), insulin (r=-0.81) and HOMA-IR index (r=-0.82) were seen in the entire examined population. We conclude, that omentin-1 is the nutritional marker reflecting body weight and insulin resistance. Our findings support the hypothesized role of omentin in maintenance of body weight and regulation of appetite and suggest the adaptation of its secretion to body weight and glucose metabolism.
authors: Department of Pediatrics, Medical University of Silesia in Katowice, Zabrze, Poland. smina@poczta.onet.pl.
authors: J
authors: J
authors: Oświęcimska
authors: A
authors: A
authors: Suwała
authors: E
authors: E
authors: Świętochowska
authors: Z
authors: Z
authors: Ostrowska
authors: P
authors: P
authors: Gorczyca
authors: K
authors: K
authors: Ziora-Jakutowicz
authors: E
authors: E
authors: Machura
authors: M
authors: M
authors: Szczepańska
authors: M
authors: M
authors: Kukla
authors: M
authors: M
authors: Stojewska
authors: D
authors: D
authors: Ziora
authors: K
authors: K
authors: Ziora
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000502:physiology; D002648:Child; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins