title: The intestinal fatty acid binding protein-2 Ala54Thr polymorphism is associated with diabetic retinopathy in Chinese population.
abstract: OBJECTIVE
  Endothelial dysfunction which is induced by serum saturated fatty acids increasing is one of pathogenesis of diabetic retinopathy (DR). The intestinal fatty acid binding protein-2 (FABP2) Ala54Thr polymorphism results in serum saturated fatty acids elevating. In the present study, we assessed the association of FABP2 gene polymorphism (Ala54Thr) with DR in Chinese population.
  
  
  METHODS
  In this case-control association study, 810 T2DM patients were recruited. 420 patients with retinal neovascularization, microneurysms and hemorrhages were considered as cases (DR) and 390 patients with T2DM and no clinical signs of retinopathy (DNR), were recruited as controls. Genotypes for FABP2(Ala54Thr) polymorphisms were assessed with the PCR-RFLP method.
  
  
  RESULTS
  A significant difference in genotype distribution and allele frequency was observed between cases and controls. Patients with DR had significantly higher frequency of the Ala/Thr + Thr/Thr genotypes compared to DNR group [62.6% vs. 46.2%; OR (95% CI), 1.95 (1.48-2.59); p < 0.001]. The DR group showed a significantly higher frequency of the the Thr allele compared to the DNR group [39.5% vs. 29.4%; OR (95% CI), 1.56 (1.16-2.09); p = 0.003]. Binary logistic analyses showed FFA levels (p = 0.014) and Ala54Thr (p = 0.011) were independent correlates of the presence of DR.
  
  
  CONCLUSIONS
  We examined that FABP2 polymophism on the Ala54Thr is significant and independent associated with DR.
authors: Key Laboratory of Hormone and Development, Ministry of Health, Tianjin Metabolic Disease Hospital, Tianjin Medical University, Tianjin, 300070 China.
authors: Zhu
authors: Z
authors: Li
authors: Key Laboratory of Hormone and Development, Ministry of Health, Tianjin Metabolic Disease Hospital, Tianjin Medical University, Tianjin, 300070 China.
authors: Chang-Lin
authors: CL
authors: Ni
authors: Key Laboratory of Hormone and Development, Ministry of Health, Tianjin Metabolic Disease Hospital, Tianjin Medical University, Tianjin, 300070 China ; Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease of the Educational Ministry of China, Tianjin Medical University, Tianjin, 300070 China.
authors: Wen-Yan
authors: WY
authors: Niu
authors: Key Laboratory of Hormone and Development, Ministry of Health, Tianjin Metabolic Disease Hospital, Tianjin Medical University, Tianjin, 300070 China.
authors: Bao-Cheng
authors: BC
authors: Chang
authors: Key Laboratory of Hormone and Development, Ministry of Health, Tianjin Metabolic Disease Hospital, Tianjin Medical University, Tianjin, 300070 China.
authors: Li-Ming
authors: LM
authors: Chen
keywords: Diabetic retinopathy; Single nucleotide polymorphism; The intestinal fatty acid binding protein-2