title: Continuous Positive Airway Pressure and the Burden of Care for Transient Tachypnea of the Neonate: Retrospective Cohort Study.
abstract: OBJECTIVE
  Transient tachypnea of the neonate (TTN) is the commonest neonatal respiratory disorder. Given TTN physiopathology, continuous positive airway pressure (CPAP) could be indicated for its treatment, but no data are available. Our aim is to clarify if CPAP might reduce the TTN burden of care.
  
  
  METHODS
  Retrospective multicenter cohort study enrolling 42 full-term TTN babies treated with CPAP and 40 with oxygen supplementation.
  
  
  RESULTS
  CPAP-treated infants show shorter intensive care unit stay (CPAP, 2.5 ± 2 vs. Oxygen, 4.4 ± 2.6 days; adjβ, -2.1 [95% confidence interval (CI): -3.1; -1]); p < 0.001) and lower maximal oxygen fraction (adjβ, -4.7 [95% CI: -7.7; -1.7]; p = 0.003). Air leak incidence was similar between the groups (adjOR, 0.36 [95% CI: 0.1; 1.1); p = 0.08). Patients' comfort as per EDIN score was also unchanged. Given the shorter length of intensive care, the use of CPAP for treating TTN would spare on average around 7,000 Euros/infant.
  
  
  CONCLUSIONS
  CPAP seems a useful therapeutics for TTN, as it may reduce the burden of care without increasing air leaks or patients' discomfort.
authors: Department of Pediatrics and Neonatology, "S. Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy.
authors: Camilla
authors: C
authors: Gizzi
authors: Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, "A. Beclere" Medical Centre, Paris, France.
authors: Roman
authors: R
authors: Klifa
authors: Department of Pediatrics and Neonatology, "S. Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy.
authors: Maria Grazia
authors: MG
authors: Pattumelli
authors: Department of Pediatrics and Neonatology, "S. Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy.
authors: Luca
authors: L
authors: Massenzi
authors: Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, "A. Beclere" Medical Centre, Paris, France.
authors: Melanie
authors: M
authors: Taveira
authors: Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, "A. Beclere" Medical Centre, Paris, France.
authors: Shivani
authors: S
authors: Shankar-Aguilera
authors: Division of Pediatrics and Neonatal Critical Care, FAME Department, South Paris University Hospitals, "A. Beclere" Medical Centre, Paris, France.
authors: Daniele
authors: D
authors: De Luca
mesh_terms: D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D012189:Retrospective Studies; D059245:Transient Tachypnea of the Newborn / Q000628:therapy*; D016896:Treatment Outcome