title: Anti-cancer activity of pegylated liposomal trans-anethole on breast cancer cell lines MCF-7 and T47D.
abstract: OBJECTIVE
  To examine the role of liposomes for the encapsulation of drugs and their suitability for chemotherapy of breast cancer.
  
  
  RESULTS
  Pegylated liposomal trans-anethole nanoparticles were synthesized through a reverse-phase evaporation technique. Nanoparticles were characterized in terms of mean diameter, size distribution, zeta potential, encapsulation and drug loading efficiency, drug release pattern and cytotoxicity effects. Size and zeta potential of pegylated nanoliposomal drug and blank pegylated nanoliposomal were 257 nm and -28 mV; 35.7 nm and -21 mV, respectively. Encapsulation and drug loading efficiency were 78 ± 2.5 and 2.3 ± 4.1 %, respectively. There was a 57 % release of trans-anethole from pegylated liposomal nanoparticles in 48 h. Compared to free drug, toxicological studies indicated around 9- and 8-fold cytotoxicity effect against MCF-7 and T47D cell lines respectively.
  
  
  CONCLUSIONS
  PEG-liposomes provided a high stability and slow release of trans-anethole in two cancer cell lines.
authors: Department of Agricultural Biotechnology, Science and Research Branch, Islamic Azad University, Tehran, Iran, shahede_shahbazian2000@yahoo.com.
authors: Shahedeh
authors: S
authors: Shahbazian
authors: Azim
authors: A
authors: Akbarzadeh
authors: Sepideh
authors: S
authors: Torabi
authors: Mansour
authors: M
authors: Omidi
mesh_terms: D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D061986:MCF-7 Cells; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000970:Antineoplastic Agents; D008081:Liposomes; D011092:Polyethylene Glycols; C006578:anethole