title: Lack of Association between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis.
abstract: Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was performed on 202 PTB patients and 204 healthy individuals. Genotyping was performed using tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). The results indicated that neither miRNA-499 rs3746444 nor miRNA-146a rs2910164 are associated with the risk of PTB in a sample of Iranian population. Larger studies with different ethnicities are required to validate our findings.
authors: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Mohammad
authors: M
authors: Naderi
authors: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Mohammad
authors: M
authors: Hashemi
authors: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Parisa
authors: P
authors: Khorgami
authors: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Maliheh
authors: M
authors: Koshki
authors: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Mahboubeh
authors: M
authors: Ebrahimi
authors: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Shadi
authors: S
authors: Amininia
authors: Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Batool
authors: B
authors: Sharifi-Mood
authors: Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. ; Genetics of Non-Communicable Diseases Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Mohsen
authors: M
authors: Taheri
keywords: Tuberculosis; miRNA-146a; miRNA-499; microRNA; polymorphism