title: [Fat-soluble vitamins supplementation in patients with cystic fibrosis: is enough Aquadek's®?].
abstract: OBJECTIVE
  Evaluate the safety and efficacy of a novel polyvitaminic (Aquadek's®) in patients with Cystic Fibrosis (CF).
  
  
  METHODS
  Prospective, longitudinal and non-randomized study. CF patients with pancreatic insufficiency and clinically stable were given Aquadek's® (two chewable tablets) daily for 12 months. Serum levels of retinol, beta-carotene, 25 OH vitamin D and α-tocopherol were evaluated twelve months before, at baseline and 12 months after.
  
  
  METHODS
  paired t tests.
  
  
  RESULTS
  28 patients aged 6 to 39 years (median 18.5 years) were included. Aquadek's® supplementation led to an increase in vitamin A dose and a decrease in the number of tablets administered. At baseline, 89% had at least one vitamin deficiency (61% pro-Vitamin A and 54% vitamin D). After one year, serum beta-carotene levels were increases 160 (95% CI 98-222) mcg/l (p <0.001) and decreased the percentage of patients with pro-vitamin A deficiency 46% (95% CI 22-64) (p <0.001). The proportion of patients with vitamin D insuficiency increased 18%(95% CI 2-32) (p =0.025). In any case serum levels exceeded the upper limits used to assess the risk of toxicity.Conclusions: Two daily Aquadek's® chewable tablets are safe and effective for maintaining vitamin A and E status of CF patients older than 6 years, although it is insufficient to normalize serum 25OHvitaminD according to the current recommendations for this disease.
authors: Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo. España.. domixixon@gmail.com.
authors: David
authors: D
authors: González Jiménez
authors: Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo. España.. ringerbou@yahoo.es.
authors: Carlos
authors: C
authors: Bousoño García
authors: Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo. España.. juanjo.diazmartin@gmail.com.
authors: Juan Jose
authors: JJ
authors: Díaz Martin
authors: Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, AGC de Pediatría, Hospital Universitario Central de Asturias, Oviedo. España.. principevegeta@hotmail.com.
authors: Santiago
authors: S
authors: Jiménez Treviño
mesh_terms: D000293:Adolescent; D000328:Adult; D001361:Avitaminosis / Q000188:drug therapy / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D010188:Exocrine Pancreatic Insufficiency / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013607:Tablets; D014815:Vitamins / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D013607:Tablets; D014815:Vitamins