title: CARD8 rs2043211 polymorphism is associated with gout in a Chinese male population.
abstract: BACKGROUND &AIM: Previous studies have suggested genetic factors are involved in the development of gout. We performed a case-control study to investigate the genetic association between CARD8 rs2043211 polymorphism and gout.
  
  
  METHODS
  A total of 396 male patients with gout and 403 age- and sex- matched healthy controls were included in this study. Genotyping was performed using TaqMan SNP Genotyping Assays. An association analysis was carried out using the χ² test. The genotype-phenotype analysis was also conducted.
  
  
  RESULTS
  The genotype distribution of CARD8 rs2043211 polymorphism confirmed to HWE in the controls (P = 0.27). There was an obvious difference in the genotype distribution of CARD8 rs2043211 polymorphism between cases and controls (P = 0.017). In addition, there was an obvious association between CARD8 rs2043211 polymorphism and gout under the recessive comparison model (AA vs.
  OR = 0.65, 95%CI 0.47-0.88, P = 0.006). Patients carrying genotype TT of CARD8 rs2043211 polymorphism had higher triglycerides levels compared to those carrying the AA genotype (2.77±2.08 mmol/L vs. 2.07±1.15 mmol/L, P = 0.01). Patients with the TT genotype also had significantly higher systolic blood pressure compared with those with the AA genotype (142.11±21.10 mmHg vs. 135.38±14.66 mmHg, P = 0.03). Patients carrying TT genotype also had an increased risk of renal calculus compared with those carrying the AA genotype.
  
  
  CONCLUSIONS
  CARD8 rs2043211 polymorphism is significantly associated with susceptibility to gout in Chinese Han males.
authors: Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Ying
authors: Y
authors: Chen
authors: Xianfeng
authors: X
authors: Ren
authors: Changgui
authors: C
authors: Li
authors: Shichao
authors: S
authors: Xing
authors: Zhengju
authors: Z
authors: Fu
authors: Ying
authors: Y
authors: Yuan
authors: Robin
authors: R
authors: Wang
authors: Yangang
authors: Y
authors: Wang
authors: Wenshan
authors: W
authors: Lv
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure; D053468:CARD Signaling Adaptor Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003710:Demography; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006073:Gout / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D053468:CARD Signaling Adaptor Proteins; C455623:CARD8 protein, human; D009363:Neoplasm Proteins; D014280:Triglycerides