title: Self-assembled autophagy-inducing polymeric nanoparticles for breast cancer interference in-vivo.
abstract: A peptide-conjugated poly(β-amino ester) that self-assembles into micelle-like nanoparticles is prepared by a convenient and modular supramolecular approach. The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy. This approach overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs: poor delivery to tumors owing to enzymatic degradation, and unstable, non-specific bio-distribution and targeting in the tumor tissues.
authors: CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, 100190, Beijing, PR China; University of Chinese Academy of Science (UCAS), No.19A Yuquan Road, 100049, Beijing, PR China.
authors: Yi
authors: Y
authors: Wang
authors: Yao-Xin
authors: YX
authors: Lin
authors: Zeng-Ying
authors: ZY
authors: Qiao
authors: Hong-Wei
authors: HW
authors: An
authors: Sheng-Lin
authors: SL
authors: Qiao
authors: Lei
authors: L
authors: Wang
authors: R P Yeshan J
authors: RP
authors: Rajapaksha
authors: Hao
authors: H
authors: Wang
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D051017:Apoptosis Regulatory Proteins / Q000008:administration & dosage* / Q000737:chemistry; D001343:Autophagy / Q000502:physiology; D000071186:Beclin-1; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism; D008565:Membrane Proteins / Q000008:administration & dosage* / Q000737:chemistry; D008819:Mice, Nude; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009368:Neoplasm Transplantation; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D055550:Protein Stability; D017433:Protein Structure, Secondary
chemical_list: D000179:Acrylates; D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D008565:Membrane Proteins; D008823:Micelles; D011108:Polymers; C507253:poly(beta-amino ester); D011092:Polyethylene Glycols; C020355:1,6-hexanediol diacrylate
keywords: breast cancer; nanoparticles; polymer; self-assembly; therapeutic peptide