title: Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression.
abstract: Recent studies have revealed the essential role played by nerves in tumor progression. Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate cancer cell growth and dissemination. This mechanism involves the release of neurotransmitters, such as catecholamines and acetylcholine, directly into the vicinity of cancer and stromal cells to activate corresponding membrane receptors. Conversely, the secretion of neurotrophic growth factors by cancer cells drives the outgrowth of nerves in solid tumors. This reciprocal interaction between nerves and cancer cells provides new insights into the cellular and molecular bases of tumorigenesis and points to the potential utility of antineurogenic therapies. This review will discuss our evolving understanding of the cross-talk between nerves and cancer cells.
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan New South Wales, Australia. Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia.
authors: Phillip
authors: P
authors: Jobling
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan New South Wales, Australia. Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia.
authors: Jay
authors: J
authors: Pundavela
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan New South Wales, Australia. Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia.
authors: Sonia M R
authors: SM
authors: Oliveira
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan New South Wales, Australia. Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia.
authors: Séverine
authors: S
authors: Roselli
authors: Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia. School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan New South Wales, Australia.
authors: Marjorie M
authors: MM
authors: Walker
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan New South Wales, Australia. Hunter Medical Research Institute, University of Newcastle, Callaghan New South Wales, Australia. hubert.hondermarck@newcastle.edu.au.
authors: Hubert
authors: H
authors: Hondermarck
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D009414:Nerve Growth Factors / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D059016:Tumor Microenvironment / Q000502:physiology
chemical_list: D009414:Nerve Growth Factors