title: Anti-tumor effects and cellular mechanisms of resveratrol.
abstract: Resveratrol (3, 5, 4'-trihydroxystilbene) is a phytoalexin contained in a variety of plants, such as grapes, berries and especially in the dried roots of Polygonum cuspidatum Sieb. et Zucc. It has been shown to exhibit anti-oxidative and anti-inflammation activity, and to reverse the effects of aging. Its ability to suppress cell proliferation, induce apoptosis and suppress the metastasis and invasion in a number of cell lines has prompted a large interest from people for its use as an anti-tumor component. In this review, evidence of resveratrol's anti-tumor effects and molecular mechanisms are recapitulated. First, we present the anti-apoptosis, anti-invasion/metastasis and anti-inflammation effect of resveratrol; second, the main signaling pathways involved in these activities are described and summarized with the studies of different tumors involved. Resveratrol not only induces apoptosis of tumor cells through intrinsic/extrinsic pathways and cell cycle arrest, but also inhibits the invasion and metastasis abilities of tumors via modulating collagen degradation-related molecular targets. Altogether, the present findings suggest the anti-tumor potential of resveratrol against various types of cancers.
authors: Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
authors: Guohua
authors: G
authors: Han
authors: Jufeng
authors: J
authors: Xia
authors: Jianjun
authors: J
authors: Gao
authors: Yoshinori
authors: Y
authors: Inagaki
authors: Wei
authors: W
authors: Tang
authors: Norihiro
authors: N
authors: Kokudo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; D020780:Matrix Metalloproteinase 9; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol