title: Particle doses in the pulmonary lobes of electronic and conventional cigarette users.
abstract: The main aim of the present study was to estimate size segregated doses from e-cigarette aerosols as a function of the airway generation number in lung lobes. After a 2-second puff, 7.7 × 10(10) particles (DTot) with a surface area of 3.6 × 10(3) mm(2) (STot), and 3.3 × 10(10) particles with a surface area of 4.2 × 10(3) mm(2) were deposited in the respiratory system for the electronic and conventional cigarettes, respectively. Alveolar and tracheobronchial deposited doses were compared to the ones received by non-smoking individuals in Western countries, showing a similar order of magnitude. Total regional doses (D(R)), in head and lobar tracheobronchial and alveolar regions, ranged from 2.7 × 10(9) to 1.3 × 10(10) particles and 1.1 × 10(9) to 5.3 × 10(10) particles, for the electronic and conventional cigarettes, respectively. D(R) in the right-upper lung lobe was about twice that found in left-upper lobe and 20% greater in right-lower lobe than the left-lower lobe.
authors: DIT, INAIL Settore Ricerca, Certificazione e Verifica, via IV Novembre 144, 00187 Rome, Italy. Electronic address: m.manigrasso@inail.it.
authors: Maurizio
authors: M
authors: Manigrasso
authors: Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Di Biasio 43, 03043 Cassino, Italy; Queensland University of Technology, Brisbane, Australia.
authors: Giorgio
authors: G
authors: Buonanno
authors: Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, via Di Biasio 43, 03043 Cassino, Italy.
authors: Luca
authors: L
authors: Stabile
authors: Queensland University of Technology, Brisbane, Australia.
authors: Lidia
authors: L
authors: Morawska
authors: DIT, INAIL Settore Ricerca, Certificazione e Verifica, via IV Novembre 144, 00187 Rome, Italy.
authors: Pasquale
authors: P
authors: Avino
mesh_terms: D000336:Aerosols; D066300:Electronic Nicotine Delivery Systems / Q000009:adverse effects; D006801:Humans; D008954:Models, Biological; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects / Q000032:analysis* / Q000493:pharmacokinetics*; D012137:Respiratory System / Q000737:chemistry*; D014018:Tissue Distribution; D062789:Tobacco Products / Q000009:adverse effects; D014028:Tobacco Smoke Pollution / Q000032:analysis*
chemical_list: D000336:Aerosols; D052638:Particulate Matter; D014028:Tobacco Smoke Pollution
keywords: Cigarette-generated particles; Electronic cigarette; Human respiratory system; Lobar bronchi; Multiple-path particle dosimetry model; Particle lobar doses