title: Targeted treatment with pazopanib in metastatic soft tissue sarcoma: Nearly complete response in two cases.
abstract: Soft tissue sarcomas (STS) are a group of rare mesenchymal cancers that include approximately 50 histological types and account for 1% of all adult cancers. The standard curative treatment option for localized disease is surgical resection and, if a surgically removed tumor exhibits high-risk characteristics, adjuvant chemotherapy and radiotherapy may be administered. Sarcoma presenting at an advanced stage has a dismal prognosis and survival has not markedly improved over the last 20 years. The standard first-line treatment for advanced STS, other than gastrointestinal stromal tumors, is cytotoxic chemotherapy. Therapies targeting pro-angiogenic factors have been a focus of drug development for STS over the last few years. Pazopanib, a multitargeted tyrosine kinase inhibitor, is a novel treatment option for patients with metastatic STS in the second-line setting. This is a presentation of 2 case reports of patients with metastatic STS who responded well to treatment with pazopanib.
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Ali Murat
authors: AM
authors: Sedef
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Fatih
authors: F
authors: Köse
authors: Internal Medicine, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Özlem
authors: Ö
authors: Doğan
authors: Radiology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Tarkan
authors: T
authors: Ergün
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Ahmet
authors: A
authors: Sezer
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Hüseyin
authors: H
authors: Mertsoylu
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Sadik
authors: S
authors: Muallaoğlu
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Ayberk
authors: A
authors: Beşen
authors: Departments of Medical Oncology, Baskent University Adana Hospital, Yuregır, Adana, Turkey.
authors: Özgur
authors: Ö
authors: Özyilkan
keywords: metastatic soft tissue sarcomas; pazopanib; response rate; targeted therapy