title: Relationship between bicuspid aortic valve phenotype, valvular function, and ascending aortic dimensions.
abstract: OBJECTIVE
  Bicuspid aortic valve (BAV) is known to be associated with aortic valve dysfunction and ascending aorta (AA) dilatation. However, the relationship between BAV morphology and AA dimensions remains unclear. Thus, the study aim was to characterize the aortic valve function and AA dimensions according to the presence of raphe and BAV phenotype.
  
  
  METHODS
  A total of 164 patients with BAV who underwent aortic valve surgery between October 2007 and November 2012 was investigated. BAV was classified as either type I (anterior-posterior orientation) or type II (right-left orientation), and subdivided as raphe+ (presence of raphe) and raphe-(no raphe).
  
  
  RESULTS
  Type I BAV was present in 103 patients (62.8%), and raphe+ in 100 (61.0%). Patients with raphe+ were typically younger than those with raphe-, and male gender was more predominant (88.0% and 53.1%, respectively, p < 0.05). Aortic regurgitation was more common in patients with type I and raphe+ BAV, and aortic stenosis in patients with type II and raphe- BAV. In patients with raphe+, the diameters of aortic annulus related to the body surface area (BSA) were larger, and the diameters of the tubular portion of AA indexed to BSA were smaller than in patients with raphe- (p < 0.05).
  
  
  CONCLUSIONS
  BAV morphology is helpful for predicting the type of aortic valve dysfunction and the location of AA dilatation.
authors: Jun Seok
authors: JS
authors: Kim
authors: Sung Min
authors: SM
authors: Ko
authors: Hyun-Keun
authors: HK
authors: Chee
authors: Je Kyoun
authors: JK
authors: Shin
authors: Meong Gun
authors: MG
authors: Song
authors: Hong Ju
authors: HJ
authors: Shin
mesh_terms: D000328:Adult; D000367:Age Factors; D001011:Aorta / Q000473:pathology*; D001021:Aortic Valve / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D000082882:Bicuspid Aortic Valve Disease; D004108:Dilatation, Pathologic; D005260:Female; D006349:Heart Valve Diseases / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors