title: High strain-rate response of injectable PAA hydrogel.
abstract: Hydrogel materials have been widely considered as potential soft tissue replacements because of their high permeability, hydrophilicity, and biocompatibility, as well as their low coefficient of friction. Injectable (thermo-responsive) hydrogels can provide support and cushioning at irregularly shaped disease sites, and are thus suitable for use in treating osteoarthritis or degenerative disc disease. However, while some injectable hydrogels have been proven to sustain human body weight during daily activities, their mechanical properties under harsh dynamic conditions have not been well documented. A specified injectable polyacrylic acid (PAA) hydrogel was prepared for this study. To simulate sudden impacts or unexpected shocks to the PAA hydrogel, the split Hopkinson pressure bar technique was utilized. The dynamic responses of various hydrogels at confined high strain rates (100-2590 s(-1)) were presented. Hydrogel specimens with 3.37, 6.75, and 13.5% acrylic acid (AAc) concentrations were tested in the following three different material conditions: raw, phosphate-buffered saline (PBS) swollen, and PBS swollen with elevated temperature (37 °C). The dynamic bulk moduli of the hydrogels varied from 1.55 to 47.8 MPa depending on the given hydrogel's AAc concentration and swollen condition.
authors: a Department of Chemical and Materials Engineering , Southern Taiwan University of Science and Technology , Tainan , Taiwan.
authors: Hong-Ru
authors: HR
authors: Lin
authors: Shih-Han
authors: SH
authors: Wang
authors: Chia-Chin
authors: CC
authors: Chiang
authors: Yun-Ching
authors: YC
authors: Juang
authors: Fu-Ann
authors: FA
authors: Yu
authors: Liren
authors: L
authors: Tsai
mesh_terms: D065966:Absorption, Physicochemical; D000180:Acrylic Resins / Q000008:administration & dosage / Q000737:chemistry*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D055598:Chemical Phenomena; D003080:Cold Temperature; D055119:Elastic Modulus; D006358:Hot Temperature; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry*; D015552:Injections, Intralesional; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D020442:Poloxamer / Q000008:administration & dosage / Q000737:chemistry*; D016062:Porosity; D011312:Pressure; D013499:Surface Properties; D055676:Viscosupplementation; D055675:Viscosupplements / Q000008:administration & dosage / Q000737:chemistry*; D014867:Water / Q000032:analysis / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D020100:Hydrogels; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D055675:Viscosupplements; D014867:Water; D020442:Poloxamer; C006903:carbopol 940
keywords: PAA; SHPB; hydrogel; strain rate; temperature