title: Aspiration-related acute respiratory distress syndrome in acute stroke patient.
abstract: BACKGROUND
  Aspiration of oral or gastric contents into the larynx and lower respiratory tract is a common problem in acute stroke patients, which significantly increases the incidence of acute respiratory distress syndrome (ARDS). However, little is known about the clinical characteristics of aspiration-related ARDS in acute stroke patients.
  
  
  METHODS
  Over 17-month period a retrospective cohort study was done on 1495 consecutive patients with acute stroke. The data including demographic characteristics, clinical manifestations, laboratory examinations, chest imaging, and hospital discharge status were collected to analysis.
  
  
  RESULTS
  Aspiration-related ARDS was diagnosed in 54 patients (3.6%). The most common presenting symptom was tachypnea (respiratory rate ≥25 breaths/min) in 50 cases. Computed tomography (CT) images usually demonstrated diffuse ground-glass opacities (GGOs) and inhomogeneous patchy consolidations involving the low lobes. Age, NIHSS score, GCS score, dysphagia, dysarthria, hemoglobin concentration, serum aspertate aminotransferase (AST), serum albumin, serum sodium, and admission glucose level were independently associated with aspiration-related ARDS (odds ratio (OR) 1.05, 95% confidence interval (CI) (1.04-1.07); OR 2.87, (2.68-3.63); OR 4.21, (3.57-5.09); OR 2.18, (1.23-3.86); OR 1.67, (1.31-2.14); OR 2.31, (1.11-4.84); OR 1.68, (1.01-2.80); OR 2.15, (1.19-3.90); OR 1.92, (1.10-3.36) and OR 1.14, (1.06-1.21) respectively).
  
  
  CONCLUSIONS
  Aspiration-related ARDS frequently occurs in acute stroke patient with impairment consciousness. It is advisable that performing chest CT timely may identify disease early and prompt treatment to rescue patients.
authors: Department of Respiratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
authors: Jiang-nan
authors: JN
authors: Zhao
authors: Department of Respiratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
authors: Yao
authors: Y
authors: Liu
authors: Department of Respiratory Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China.
authors: Huai-chen
authors: HC
authors: Li
mesh_terms: D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D003680:Deglutition Disorders / Q000473:pathology; D004401:Dysarthria / Q000473:pathology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016017:Odds Ratio; D053120:Respiratory Aspiration / Q000150:complications*; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000473:pathology*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D012964:Sodium / Q000097:blood; D020521:Stroke / Q000150:complications*; D059246:Tachypnea / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D012709:Serum Albumin; D012964:Sodium; D001219:Aspartate Aminotransferases