title: Rs4948496 within ARID5B gene is associated with clinical features of systemic lupus erythematosus in the Chinese Han population.
abstract: In our previous meta-analysis of genome-wide association study, we identified the single nucleotide polymorphism (SNP) rs4948496 (P = 5.1 × 10(-11) , odds ratio [OR] = 0.85) within the ARID5B gene associated with systemic lupus erythematosus (SLE) in a Chinese population. To investigate its association with disease subphenotypes, we further analyzed the genotype data of rs4948496 in 4348 cases and 6679 controls from our previous meta-analysis and an independent replication cohort in this study. The SNP rs4948496 was significantly associated with SLE (P = 1.61 × 10(-5) , OR = 0.88, 95% confidence interval [CI] = 0.83-0.93) in our group. In case-only study, the genotype of rs4948496 was associated with antinuclear antibodies (P = 0.03, OR = 0.81, 95% CI = 0.68-0.98) and anti-RNP (P = 0.03, OR = 0.86, 95% CI = 0.76-0.99). This study showed that rs4948496 in ARID5B is associated with several subphenotypes of SLE and this gene may cause the complicacy of clinical features.
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Long
authors: L
authors: Jiang
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Jianping
authors: J
authors: Wu
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Weiran
authors: W
authors: Li
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Juan
authors: J
authors: Du
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Wenjun
authors: W
authors: Wang
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Zhengwei
authors: Z
authors: Zhu
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Jinping
authors: J
authors: Gao
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Yujun
authors: Y
authors: Sheng
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Xianyong
authors: X
authors: Yin
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Xiaodong
authors: X
authors: Zheng
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Hui
authors: H
authors: Li
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Yang
authors: Y
authors: Li
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Li
authors: L
authors: Meng
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Xing
authors: X
authors: Fan
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Shengxiu
authors: S
authors: Liu
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Ming
authors: M
authors: Zeng
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Zaixing
authors: Z
authors: Wang
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Yong
authors: Y
authors: Cui
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Huayang
authors: H
authors: Tang
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Liangdan
authors: L
authors: Sun
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Sen
authors: S
authors: Yang
authors: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, Hefei, China.|Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, Hefei, China.
authors: Xuejun
authors: X
authors: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000097:blood; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000208:ethnology; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
chemical_list: C503805:ARID5B protein, human; D000974:Antibodies, Antinuclear; D004268:DNA-Binding Proteins; D014157:Transcription Factors
keywords: genotype; phenotype; single nucleotide polymorphism; susceptibility gene; systemic lupus erythematosus