title: Tuberculosis elimination in the post Millennium Development Goals era.
abstract: The Millennium Development Goal for tuberculosis (TB) is to stop the increase in incidence and halve the mortality of TB between 1990 and 2015. This goal has now been reached on a global scale, although not in the most affected region of Africa. The new target is TB elimination, defined as one case of active TB per one million population per year, which is to be reached before 2050. This review will discuss the main tools in play, namely case-finding and new diagnostics, increased access and effectiveness of anti-TB therapy (directly observed therapy, short course (DOTS)), preventive therapy for latent infection, and vaccination. Each approach is discussed and a way forward in research and management is suggested.
authors: GloHAU, Center for Global Health, School of Public Health, Aarhus University, Bartholins Alle 2, 8000 Aarhus C, Denmark; Deparment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark; Bandim Health Project, Guinea Bissau. Electronic address: wejse@dadlnet.dk.
authors: Christian
authors: C
authors: Wejse
mesh_terms: D000349:Africa / Q000453:epidemiology; D023801:Directly Observed Therapy; D006040:Goals; D006801:Humans; D015994:Incidence; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D032581:Tuberculosis Vaccines
chemical_list: D032581:Tuberculosis Vaccines
keywords: Case-finding; Elimination; Preventive therapy; Tuberculosis