title: Asymmetric Suzuki-Miyaura cross-coupling of 1-bromo-2-naphthoates using the helically chiral polymer ligand PQXphos.
abstract: A single-handed helical polymer ligand PQXphos afforded axially chiral biaryl esters with high enantioselectivities in asymmetric Suzuki-Miyaura cross-coupling. The use of naphthyl bromide bearing a 2,4-dimethyl-3-pentyl ester resulted in both high yields and high enantioselectivities. Either enantiomer could be synthesized selectively by using a single PQXphos through a solvent-dependent switch of the helical chirality.
authors: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan. suginome@sbchem.kyoto-u.ac.jp.
authors: Yuto
authors: Y
authors: Akai
authors: Laure
authors: L
authors: Konnert
authors: Takeshi
authors: T
authors: Yamamoto
authors: Michinori
authors: M
authors: Suginome
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D008024:Ligands; D009281:Naphthalenes; D011108:Polymers; C085312:1-naphthoic acid