title: Pityriasis Lichenoides in Childhood: Review of Clinical Presentation and Treatment Options.
abstract: Pityriasis lichenoides (PL) is a skin condition of unclear etiology that occurs not uncommonly in childhood. It is often classified into the acute form, pityriasis lichenoides et varioliformis acuta (PLEVA), and the chronic form, pityriasis lichenoides chronica (PLC). We performed a comprehensive review of the English-language literature using the PubMed database of all cases of childhood PL reported from 1962 to 2014 and summarized the epidemiology, clinical features, treatment options, and prognosis of this condition in children. The proposed etiologies are discussed, including its association with infectious agents, medications, and immunizations and evidence for PL as a lymphoproliferative disorder. We found an average age of PL onset of 6.5 years, with a slight (61%) male predominance. We also found that PLEVA and PLC tend to occur with equal frequency and that, in many cases, there is clinical and histopathologic overlap between the two phenotypes. When systemic therapy is indicated, we propose that oral erythromycin and narrowband ultraviolet B phototherapy should be first-line treatment options for children with PL since they have been shown to be effective and well tolerated. In most cases, PL follows a benign course with no greater risk of cutaneous T-cell lymphoma, although given the rare case reports of transformation, long-term follow-up of these patients is recommended.
authors: Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.|Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
authors: Lauren
authors: L
authors: Geller
authors: College of Physicians and Surgeons, Columbia University, New York, New York.
authors: Nina K
authors: NK
authors: Antonov
authors: Department of Dermatology, Columbia University, New York, New York.|Department of Pediatrics, Columbia University, New York, New York.
authors: Christine T
authors: CT
authors: Lauren
authors: Department of Dermatology, Columbia University, New York, New York.|Department of Pediatrics, Columbia University, New York, New York.
authors: Kimberly D
authors: KD
authors: Morel
authors: Department of Dermatology, Columbia University, New York, New York.|Department of Pediatrics, Columbia University, New York, New York.
authors: Maria C
authors: MC
authors: Garzon
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001707:Biopsy, Needle; D002648:Child; D002981:Clindamycin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D017514:Pityriasis Lichenoides / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D012737:Sex Factors; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*
chemical_list: D002981:Clindamycin