title: Diabetes and Alzheimer disease, two overlapping pathologies with the same background: oxidative stress.
abstract: There are several oxidative stress-related pathways interconnecting Alzheimer's disease and type II diabetes, two public health problems worldwide. Coincidences are so compelling that it is attractive to speculate they are the same disorder. However, some pathological mechanisms as observed in diabetes are not necessarily the same mechanisms related to Alzheimer's or the only ones related to Alzheimer's pathology. Oxidative stress is inherent to Alzheimer's and feeds a vicious cycle with other key pathological features, such as inflammation and Ca(2+) dysregulation. Alzheimer's pathology by itself may lead to insulin resistance in brain, insulin resistance being an intervening variable in the neurodegenerative disorder. Hyperglycemia and insulin resistance from diabetes, overlapping with the Alzheimer's pathology, aggravate the progression of the neurodegenerative processes, indeed. But the same pathophysiological background is behind the consequences, oxidative stress. We emphasize oxidative stress and its detrimental role in some key regulatory enzymes.
authors: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Sierra Mojada 800, Colonia Independencia, 44340 Guadalajara, JAL, Mexico.
authors: Sergio
authors: S
authors: Rosales-Corral
authors: Department of Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors: Dun-Xian
authors: DX
authors: Tan
authors: Department of Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors: Lucien
authors: L
authors: Manchester
authors: Department of Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
authors: Russel J
authors: RJ
authors: Reiter
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology*; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008928:Mitochondria / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D018384:Oxidative Stress; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D013879:Thioredoxins; D009249:NADP; D005978:Glutathione; D002118:Calcium