title: Glycyrrhizic acid derivatives as influenza A/H1N1 virus inhibitors.
abstract: This Letter describes the synthesis and antiviral activity study of some glycyrrhizic acid (GL) derivatives against influenza A/H1N1/pdm09 virus in MDCK cells. Conjugation of GL with l-amino acids or their methyl esters, and amino sugar (d-galactose amine) dramatically changed its activity. The most active compounds were GL conjugates with aromatic amino acids methyl esters (phenylalanine and tyrosine) (SI=61 and 38), and S-benzyl-cysteine (SI=71). Thus modification of GL is a perspective route in the search of new antivirals, and some of GL derivatives are potent as anti-influenza A/H1N1 agents.
authors: Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation. Electronic address: baltina@anrb.ru.
authors: Lidia A
authors: LA
authors: Baltina
authors: Influenza Research Institute, Ministry of Health of Russia, 15/17, prof. Popov str., St. Peterburg 197376, Russian Federation.
authors: Vladimir V
authors: VV
authors: Zarubaev
authors: Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation.
authors: Lia A
authors: LA
authors: Baltina
authors: Influenza Research Institute, Ministry of Health of Russia, 15/17, prof. Popov str., St. Peterburg 197376, Russian Federation.
authors: Iana A
authors: IA
authors: Orshanskaya
authors: Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation.
authors: Alina I
authors: AI
authors: Fairushina
authors: Influenza Research Institute, Ministry of Health of Russia, 15/17, prof. Popov str., St. Peterburg 197376, Russian Federation.
authors: Oleg I
authors: OI
authors: Kiselev
authors: Institute of Organic Chemistry Ufa Research Centre of Russian Academy of Sciences, 71, prospect Oktyabrya, Ufa 450054, Russian Federation.
authors: Marat S
authors: MS
authors: Yunusov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D019695:Glycyrrhizic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D053118:Influenza A Virus, H1N1 Subtype / Q000502:physiology; D061985:Madin Darby Canine Kidney Cells; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D019695:Glycyrrhizic Acid
keywords: Analogs; Antivirals; Derivatives; Glycyrrhizic acid; Influenza A/H1N1 virus