title: The effects of cyclosporin A and Heteropterys tomentosa on the rat liver.
abstract: Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15 mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment.
authors: Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Karine M
authors: KM
authors: de Freitas
authors: Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Jacqueline M
authors: JM
authors: Almeida
authors: Departamento de Ciências Agronômicas e Biológicas, Universidade Federal do Espírito Santo, São Mateus, ES, Brasil.
authors: Juliana C
authors: JC
authors: Monteiro
authors: Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Maria Aparecida S
authors: MA
authors: Diamante
authors: Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Jéssica S F do
authors: JS
authors: Vale
authors: Departamento de Bioquímica, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Camila
authors: C
authors: Camargo
authors: Empresa Brasileira de Pesquisa Agropecuária, Gama, DF, Brasil.
authors: Marçal H A
authors: MH
authors: Jorge
authors: Departamento de Biologia Estrutural e Funcional, Universidade Estadual de Campinas, Campinas, SP, Brasil.
authors: Heidi
authors: H
authors: Dolder
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D016572:Cyclosporine / Q000008:administration & dosage / Q000633:toxicity*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D029581:Malpighiaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D010936:Plant Extracts; D016572:Cyclosporine