title: Palladium-catalyzed aminocarbonylation of N-chloroamines with boronic acids.
abstract: Aryl (pseudo)halide-based (C-X) carbonylation reactions have been extensively studied during the past few decades. From both academic and synthetic points of view, the carbonylative transformation of N-X bonds represents an interesting and attractive area of investigation. In light of this, the first carbonylative cross-coupling between N-chloroamines and organoboronic acids has been developed. This new type of aminocarbonylation proceeds at mild temperatures (45-55 °C) with 2 mol % Pd/C (10 wt %) as the ligand-free catalyst. Not only arylboronic acids, but also alkenyl- and alkylboronic acids can be applied as the substrates and bromide and iodide substituents in the substrates are well tolerated. Initial mechanistic investigations have also been performed.
authors: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29 a, 18059 Rostock (Germany).
authors: Wanfang
authors: W
authors: Li
authors: Xiao-Feng
authors: XF
authors: Wu
keywords: N-chloroamine; amides; aminocarbonylation; boronic acids; palladium