title: Graphene oxide-encoded Ag nanoshells with single-particle detection sensitivity towards cancer cell imaging based on SERRS.
abstract: Developing ultrasensitive Raman nanoprobes is one of the emerging interests in the field of biosensing and bioimaging. Herein, we constructed a new type of surface-enhanced resonance Raman scattering nanoprobe composed of an Ag nanoshell as a surface-enhanced Raman scattering-active nanostructure, which was encapsulated with 4,7,10-trioxa-1,13-tridecanediamine-functionalized graphene oxide as an ultrasensitive Raman reporter exhibiting strong resonance Raman scattering including distinct D and G modes. The designed nanoprobe was able to produce much more intense and simpler Raman signals even at a single particle level than the Ag nanoshell bearing a well-known Raman reporter, which is beneficial for the sensitive detection of a target in a complex biological system. Finally, this ultrasensitive nanoprobe successfully demonstrated its potential for bioimaging of cancer cells using Raman spectroscopy.
authors: Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea. kjh75@hanyang.ac.kr.
authors: DaBin
authors: D
authors: Yim
authors: Homan
authors: H
authors: Kang
authors: Su-Ji
authors: SJ
authors: Jeon
authors: Hye-In
authors: HI
authors: Kim
authors: Jin-Kyoung
authors: JK
authors: Yang
authors: Tae Wook
authors: TW
authors: Kang
authors: Sangyeop
authors: S
authors: Lee
authors: Jaebum
authors: J
authors: Choo
authors: Yoon-Sik
authors: YS
authors: Lee
authors: Jin Woong
authors: JW
authors: Kim
authors: Jong-Ho
authors: JH
authors: Kim
mesh_terms: D000588:Amines / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D061986:MCF-7 Cells; D008958:Models, Molecular; D008968:Molecular Conformation; D057054:Molecular Imaging / Q000379:methods*; D057145:Nanoshells / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D000588:Amines; D010087:Oxides; D012834:Silver; D012822:Silicon Dioxide; D006108:Graphite