title: Interactions between environmental factors and melatonin receptor type 1A polymorphism in relation to oral cancer susceptibility and clinicopathologic development.
abstract: BACKGROUND
  The purpose of this study was to explore the combined effect of melatonin receptor type 1A (MTNR1A) gene polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of oral cancer.
  
  
  RESULTS
  Three polymorphisms of the MTNR1A gene from 618 patients with oral cancer and 560 non-cancer controls were analyzed by real-time polymerase chain reaction (PCR). The CTA haplotype of the studied MTNR1A polymorphisms (rs2119882, rs13140012, rs6553010) was related to a higher risk of oral cancer. Moreover, MTNR1A gene polymorphisms exhibited synergistic effects of environmental factors (betel quid and tobacco use) on the susceptibility of oral cancer. Finally, oral-cancer patients with betel quid-chewing habit who had T/T allele of MTNR1A rs13140012 were at higher risk for developing an advanced clinical stage and lymph node metastasis.
  
  
  CONCLUSIONS
  These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.
authors: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Feng-Yan
authors: FY
authors: Lin
authors: Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan; Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Chiao-Wen
authors: CW
authors: Lin
authors: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Shun-Fa
authors: SF
authors: Yang
authors: Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Wei-Jiunn
authors: WJ
authors: Lee
authors: Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Yung-Wei
authors: YW
authors: Lin
authors: Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Liang-Ming
authors: LM
authors: Lee
authors: Department of Medical Management, Taoyuan Armed Forces General Hospital, Taoyuan County, Taiwan; School of Medicine, Pathology Department, National Defense Medical Center, Taipei, Taiwan.
authors: Junn-Liang
authors: JL
authors: Chang
authors: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Division of Urology, Department of Surgery, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.
authors: Wei-Chun
authors: WC
authors: Weng
authors: Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan.
authors: Chien-Huang
authors: CH
authors: Lin
authors: Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan; Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors: Ming-Hsien
authors: MH
authors: Chien
mesh_terms: D000483:Alleles; D001114:Areca / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide; D044094:Receptors, Melatonin / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D064424:Tobacco Use / Q000009:adverse effects
chemical_list: D044094:Receptors, Melatonin