title: Clinical picture, outcome and predictive factors of lymphoma in Sjӧgren syndrome.
abstract: The intrinsic and complex nature of primary Sjӧgren's syndrome (pSS) makes it difficult to identify risk factors that can predict the development and outcome of non-Hodgkin's lymphoma (NHL), yet patients at high risk for such complication seem to bear certain clinic-serological characteristics that render them a unique profile. In the last decade, research focusing on B-cell hyperactivity as the hallmark of pSS-related lymphoproliferation has shed light on certain biological and molecular factors that participate in disease evolution and lymphoma development, thus indicating possible predictors of lymphoma development and outcome. In this review, we explore all the available data concerning the clinical picture, risk prognostication and outcome of pSS-associated NHLs.
authors: Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
authors: Aristea
authors: A
authors: Papageorgiou
authors: Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece.
authors: Michael
authors: M
authors: Voulgarelis
authors: Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece. Electronic address: agtzi@med.uoa.gr.
authors: Athanasios G
authors: AG
authors: Tzioufas
mesh_terms: D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D011379:Prognosis; D012307:Risk Factors; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology*
keywords: Lymphoma; Outcome; Predictors; Prognosis; Sjӧgren's syndrome