title: Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype.
abstract: Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes the interconversion of pyruvate and lactate. However, the roles of LDHB in glycolysis and tumor progression were obscure in different types of cancer. Here, we determined the roles of LDHB in pancreatic cancer development and progression. We found suppressed expression of LDHB in pancreatic cancer which was due to promoter hypermethylation and deceased expression of LDHB led to glycolytic transition. Functional analysis revealed that suppressed expression of LDHB promoted pancreatic cancer cells proliferation, invasion, and migration in hypoxia. Thus, LDHB might function as a suppressor of glycolysis and suppressed pancreatic cancer progression.
authors: Department of Oncology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, People's Republic of China.
authors: Jiujie
authors: J
authors: Cui
authors: Ming
authors: M
authors: Quan
authors: Weihua
authors: W
authors: Jiang
authors: Hai
authors: H
authors: Hu
authors: Feng
authors: F
authors: Jiao
authors: Ning
authors: N
authors: Li
authors: Ziliang
authors: Z
authors: Jin
authors: Lei
authors: L
authors: Wang
authors: Yu
authors: Y
authors: Wang
authors: Liwei
authors: L
authors: Wang
mesh_terms: D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006019:Glycolysis / Q000235:genetics*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D007770:L-Lactate Dehydrogenase