title: Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy.
abstract: OBJECTIVE
  To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN.
  
  
  METHODS
  102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed.
  
  
  RESULTS
  Several findings were demonstrated with the increase of serum HBV DNA: 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly (P%lt;0.05), while the plasma level of albumin decreased significantly (P%lt;0.05); The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group (P%lt;0.01).
  
  
  CONCLUSIONS
  With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased.
authors: Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
authors: Wei
authors: W
authors: Jiang
authors: National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors: Tuo
authors: T
authors: Liu
authors: Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
authors: Hui
authors: H
authors: Dong
authors: Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
authors: Yan
authors: Y
authors: Xu
authors: Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China.
authors: Li Qiu
authors: LQ
authors: Liu
authors: Department of Nephrology, The Second Hospital of Shandong University, Jinan 250100, Shandong, China.
authors: Guang Ju
authors: GJ
authors: Guan
authors: Department of Nephrology, The Second Hospital of Shandong University, Jinan 250100, Shandong, China.
authors: Xiang Chun
authors: XC
authors: Liu
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D004261:DNA Replication; D004279:DNA, Viral / Q000097:blood*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology*; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D019259:Lamivudine; D000225:Adenine; C106812:adefovir dipivoxil
keywords: Adefovir dipivoxil; Hepatitis B virus; Lamivudine; Nephritis; Pathology; Proteinuria