title: Effective binding of a phosphatidylserine-targeting antibody to Ebola virus infected cells and purified virions.
abstract: Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
authors: Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK.
authors: S D
authors: SD
authors: Dowall
authors: Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK.
authors: V A
authors: VA
authors: Graham
authors: Peregrine Pharmaceuticals, Inc., Tustin, CA 92780, USA.
authors: K
authors: K
authors: Corbin-Lickfett
authors: Peregrine Pharmaceuticals, Inc., Tustin, CA 92780, USA.
authors: C
authors: C
authors: Empig
authors: Peregrine Pharmaceuticals, Inc., Tustin, CA 92780, USA.
authors: K
authors: K
authors: Schlunegger
authors: Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK.
authors: C B
authors: CB
authors: Bruce
authors: Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK.
authors: L
authors: L
authors: Easterbrook
authors: Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK.
authors: R
authors: R
authors: Hewson
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology* / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D029043:Ebolavirus / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D019142:Hemorrhagic Fever, Ebola / Q000276:immunology / Q000821:virology; D006801:Humans; D010718:Phosphatidylserines / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding / Q000276:immunology; D014709:Vero Cells; D014771:Virion / Q000276:immunology* / Q000378:metabolism
chemical_list: D000914:Antibodies, Viral; D010718:Phosphatidylserines