title: Relaxant effects of selected sildenafil analogues in the rat aorta.
abstract: A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine with chiral amino group has been synthesized and characterized. The compounds were tested for their relaxant effects in the rat aorta. Evaluation of prepared derivatives demonstrated that compound (8a) is probably a non-selective phosphodiesterase (PDE) inhibitor, as it induced aortic relaxation through endothelium-independent mechanism.
authors: a Department of Chemistry , Siedlce University of Natural Sciences and Humanities , Siedlce , Poland .
authors: Mariusz
authors: M
authors: Mojzych
authors: b Department of Pharmacodynamics , Jagiellonian University Medical College , Kraków , Poland , and.
authors: Monika
authors: M
authors: Kubacka
authors: b Department of Pharmacodynamics , Jagiellonian University Medical College , Kraków , Poland , and.
authors: Szczepan
authors: S
authors: Mogilski
authors: b Department of Pharmacodynamics , Jagiellonian University Medical College , Kraków , Poland , and.
authors: Barbara
authors: B
authors: Filipek
authors: c Department of Chemistry , Laboratory of Separation and Spectroscopic Method Applications, Center for Interdisciplinary Research, The John Paul II Catholic University of Lublin , Lublin , Poland.
authors: Emilia
authors: E
authors: Fornal
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000502:physiology*; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D015394:Molecular Structure; D058986:Phosphodiesterase 5 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D058986:Phosphodiesterase 5 Inhibitors; D000068677:Sildenafil Citrate; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5
keywords: PDE5 inhibitors; pyrazolo[4,3-e][1,2,4]triazine; relaxant effect; sildenafil analogues; sulfonamides