title: Trehalolipid biosurfactants from nonpathogenic Rhodococcus actinobacteria with diverse immunomodulatory activities.
abstract: Actinobacteria of the genus Rhodococcus produce trehalolipid biosurfactants with versatile biochemical properties and low toxicity. In recent years, these biosurfactants are increasingly studied as possible biomedical agents with expressed immunological activities. Applications of trehalolipids from Rhodococcus, predominantly cell-bound, in biomedicine are also attractive because their cost drawback could be less significant for high-value products. The review summarizes recent findings in immunomodulatory activities of trehalolipid biosurfactants from nonpathogenic Rhodococcus and related actinobacteria and compares their biomedical potential with well-known immunomodifying properties of trehalose dimycolates from Mycobacterium tuberculosis. Molecular mechanisms of trehalolipid interactions with immunocompetent cells are also discussed.
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia; Microbiology and Immunology Department, Perm State University, Perm, Russia. Electronic address: kuyukina@iegm.ru.
authors: Maria S
authors: MS
authors: Kuyukina
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia; Microbiology and Immunology Department, Perm State University, Perm, Russia.
authors: Irena B
authors: IB
authors: Ivshina
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
authors: Tatiana A
authors: TA
authors: Baeva
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia.
authors: Olesia A
authors: OA
authors: Kochina
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia; Microbiology and Immunology Department, Perm State University, Perm, Russia.
authors: Sergey V
authors: SV
authors: Gein
authors: Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences, Perm, Russia; Microbiology and Immunology Department, Perm State University, Perm, Russia; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
authors: Valery A
authors: VA
authors: Chereshnev
mesh_terms: D000818:Animals; D007155:Immunologic Factors / Q000096:biosynthesis* / Q000276:immunology*; D008055:Lipids / Q000276:immunology*; D051379:Mice; D012240:Rhodococcus / Q000145:classification* / Q000276:immunology / Q000378:metabolism*; D013045:Species Specificity; D013501:Surface-Active Agents / Q000378:metabolism*
chemical_list: D007155:Immunologic Factors; D008055:Lipids; D013501:Surface-Active Agents