title: Development of a touch-screen-based paradigm for assessing working memory in the mouse.
abstract: Assessing the working memory of the rodent by using a touch-screen system has several advantages (e.g., allowing highly accurate data collection and flexibility in memory task design). However, there is currently no available testing paradigm utilizing touch-screen systems that can assess working memory in the mouse. In this study, we developed a touch-screen testing paradigm in which mice were trained to choose a location that is matched to a sample location after a time delay. Consistent with previous studies, this study showed that mice could not only learn the rule in the delayed matched to position (DMTP), but also could retain a transitory memory of the sample position during delay. This indicates that a touch-screen system can provide a DMTP testing platform to assess working memory in the mouse.
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Chuljung
authors: C
authors: Kwak
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Chae-Seok
authors: CS
authors: Lim
authors: Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors: Bong-Kiun
authors: BK
authors: Kaang
keywords: delayed match to position; mouse cognition; touch screen; working memory