title: Histiocytic glomerulopathy associated with macrophage activation syndrome.
abstract: We present an interesting case of a 37-year old man with acute renal failure following a febrile illness. Laboratory results showed features of macrophage activation syndrome (MAS) with anemia, thrombocytopenia, hypofibrinogenemia and elevated ferritin levels. Renal biopsy was then done to determine the cause of renal failure and showed unique glomerular findings with massive histiocytic infiltration ('histiocytic glomerulopathy') and evidence of endothelial injury. Recognizing that the histiocytic infiltrate and endothelial injury is a part of MAS is important because early recognition and treatment is of utmost importance since the disease can be fatal.
authors: Division of Nephrology and Hypertension, Department of Internal Medicine , Mayo Clinic , Rochester, MN , USA.
authors: Alfonso
authors: A
authors: Eirin
authors: Division of Nephrology and Hypertension, Department of Internal Medicine , Mayo Clinic , Rochester, MN , USA.
authors: Maria V
authors: MV
authors: Irazabal
authors: Division of Nephrology and Hypertension, Department of Internal Medicine , Mayo Clinic , Rochester, MN , USA.
authors: Fernando C
authors: FC
authors: Fervenza
authors: Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology , Mayo Clinic , Rochester, MN , USA.
authors: Sanjeev
authors: S
authors: Sethi
keywords: hemophagocytic syndrome; histiocytosis; macrophage; macrophage activation syndrome; thrombotic microangiopathy