title: Incidence and severity of atherosclerotic cardiovascular artery disease in patients undergoing TAVI.
abstract: Transcatheter aortic valve implantation (TAVI) has extended the treatment options for severe, symptomatic aortic valve stenosis (AS). Risk factors for AS have been shown to be similar to atherosclerosis. Consequently, coronary artery disease (CAD), peripheral vascular and carotid artery diseases are often found concurrently with diagnostic, procedural and prognostic implications. This study sought to describe comprehensive vascular assessment in terms of prevalence, severity and correlations in TAVI candidates. A total of 323 patients (81 ± 6 years) undergoing TAVI were enrolled. Vascular pathologies were evaluated by invasive coronary angiography, computer-tomography (abdominal aorta, renal, iliac and femoral arteries), echo-color Doppler ultrasound (carotid artery), and transoesophageal echocardiography (thoracic aorta). CAD was found in 173 (54%) patients, of which 65 (38%) had 1-vessel, 45 (26%) 2-vessel and 59 (34%) 3-vessel disease. Carotid artery disease was present in 33.6% patients, of which 23.6% unilateral and 10.0% bilateral. Iliac, femoral and renal stenosis were found in 29.2%, 22.0%, and 4.7%, respectively. Cardiovascular risk factor and gender correlated with CAD. CAD patients presented more frequently with significant stenosis (luminal narrowing ≥ 50%) of at least one other district. Multi-districts significant stenosis stratified patients on long-term survival and the coexistence of 3-districts involvement with CAD negatively impacts on mortality. Multimodality imaging assessment shows that coronary, carotid, and peripheral artery disease are often found concurrently in patients undergoing TAVI. Several risk factors and gender correlate with the presence and severity of CAD and peripheral pathologies. Long-term mortality is increased in patients with a more compromised vascular situation.
authors: Centro Cardiologico Monzino IRCCS, Milan, Italy, lfusini@ccfm.it.
authors: Laura
authors: L
authors: Fusini
authors: Oana
authors: O
authors: Mirea
authors: Gloria
authors: G
authors: Tamborini
authors: Manuela
authors: M
authors: Muratori
authors: Paola
authors: P
authors: Gripari
authors: Claudia
authors: C
authors: Cefalù
authors: Sarah
authors: S
authors: Ghulam Ali
authors: Francesco
authors: F
authors: Maffessanti
authors: Daniele
authors: D
authors: Andreini
authors: Gianluca
authors: G
authors: Pontone
authors: Antonio L
authors: AL
authors: Bartorelli
authors: Francesco
authors: F
authors: Alamanni
authors: Marco
authors: M
authors: Agrifoglio
authors: Mauro
authors: M
authors: Pepi
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D016893:Carotid Stenosis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006801:Humans; D015994:Incidence; D007558:Italy; D053208:Kaplan-Meier Estimate; D008297:Male; D061330:Multidetector Computed Tomography; D064847:Multimodal Imaging / Q000379:methods; D016491:Peripheral Vascular Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome