title: Capgras syndrome in a very late onset, treatment resistant schizophrenia.
abstract: We report a Malay man, with underlying chronic medical illnesses, presenting with positive symptoms of schizophrenia, including Capgras syndrome (CS) at the age of 73. Physical examination and blood investigations were normal and brain CT scan showed age-related cerebral atrophy. Neuropsychological assessment showed probable right hemisphere lesions but relatively intact memory and intellectual functions. Several neuroleptics including depot injections were tried but ineffective. Positive symptoms including CS eventually improved with clozapine before his death from myocardial infarction. This case report highlights the uncommon occurrence of CS in treatment resistant schizophrenia (TRS) of very late onset and its treatment challenges.
authors: Department of Psychiatry,Faculty of Medicine,Universiti Kebangsaan Malaysia Medical Centre,56000,Kuala Lumpur,Malaysia.
authors: M K Nurul
authors: MK
authors: Ain
authors: Department of Psychiatry,Faculty of Medicine,Universiti Kebangsaan Malaysia Medical Centre,56000,Kuala Lumpur,Malaysia.
authors: R
authors: R
authors: Rosdinom
authors: Department of Psychiatry,Faculty of Medicine,Universiti Kebangsaan Malaysia Medical Centre,56000,Kuala Lumpur,Malaysia.
authors: M
authors: M
authors: Raynuha
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001344:Autopsy; D002194:Capgras Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D003024:Clozapine / Q000627:therapeutic use*; D015897:Comorbidity; D003702:Delusions; D006801:Humans; D000067562:Late Onset Disorders; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: Capgras syndrome; elderly; treatment resistant schizophrenia; very late onset schizophrenia