title: MICA∗078: A novel allele identified in a Moroccan individual affected by celiac disease.
abstract: A novel MICA allele, MICA(∗)078, has been identified during HLA/MICA high resolution typing of Moroccan patients with celiac disease. MICA(∗)078 shows an uncommon variation at a highly conserved nucleotide position (nt 493, G → A), resulting in one amino acid change at codon 142 (V → I) of MICA gene (compared to MICA(∗)002:01), located in the α2-domain, in which V142 is the common residue.
authors: National Research Council (CNR), Institute of Translational Pharmacology, U.O.S. L'Aquila, Italy. Electronic address: daniela.piancatelli@cnr.it.
authors: Daniela
authors: D
authors: Piancatelli
authors: Institute National d'Hygiene, Rabat, Morocco.
authors: Khadija
authors: K
authors: Oumhani
authors: Medicine C, Dep. of Gastroenterology, Ibn Sina Hospital, Mohammed V-Souissi University, Rabat, Morocco.
authors: Imane
authors: I
authors: Benelbarhdadi
authors: National Research Council (CNR), Institute of Translational Pharmacology, U.O.S. L'Aquila, Italy.
authors: Tiziana
authors: T
authors: Del Beato
authors: National Research Council (CNR), Institute of Translational Pharmacology, U.O.S. L'Aquila, Italy.
authors: Alessia
authors: A
authors: Colanardi
authors: National Research Council (CNR), Institute of Translational Pharmacology, U.O.S. L'Aquila, Italy.
authors: Pierluigi
authors: P
authors: Sebastiani
authors: University of L'Aquila, Italy.
authors: Alessandra
authors: A
authors: Tessitore
authors: Hassan II Academy of Science and Technology, Rabat, Morocco.
authors: Rajae
authors: R
authors: El Aouad
authors: Medicine C, Dep. of Gastroenterology, Ibn Sina Hospital, Mohammed V-Souissi University, Rabat, Morocco.
authors: Abdellah
authors: A
authors: Essaid
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D002446:Celiac Disease / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D003062:Codon; D005260:Female; D018703:Founder Effect; D015870:Gene Expression; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008875:Middle Aged; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009018:Morocco; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D003062:Codon; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A
keywords: Allele; Celiac; MICA; SBT