title: Molecular diagnostics.
abstract: Orthopaedic infections are complex conditions that require immediate diagnosis and accurate identification of the causative organisms to facilitate appropriate management. Conventional methodologies for diagnosis of these infections sometimes lack accuracy or sufficient rapidity. Molecular diagnostics is an emerging area of bench-to-bedside research in orthopaedic infections. Examples of promising molecular diagnostics include measurement of a specific biomarker in the synovial fluid, polymerase chain reaction-based detection of bacterial genes, and metabolomic determination of responses to orthopaedic infection.
authors: Hyonmin
authors: H
authors: Choe
authors: Carl A
authors: CA
authors: Deirmengian
authors: Noreen J
authors: NJ
authors: Hickok
authors: Tiffany N
authors: TN
authors: Morrison
authors: Rocky S
authors: RS
authors: Tuan
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001850:Bone Diseases, Infectious / Q000175:diagnosis*; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D055442:Metabolome / Q000276:immunology; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D016133:Polymerase Chain Reaction; D016459:Prosthesis-Related Infections / Q000175:diagnosis; D013582:Synovial Fluid / Q000382:microbiology
chemical_list: D015415:Biomarkers; D004269:DNA, Bacterial