title: [The effect of electrical stimulation of nucleus tractus solitarius on cardiac nociception and its spinal cord mechanism in rat].
abstract: OBJECTIVE
  Examine the effect of electrical stimulation of nucleus tractus solitaries (NTS) on cardiac-somatic motor reflex (CMR) that induced by intrapericardial administration of capsaicin to clarify the spinal cord mechanism of NTS involved in cardiac nociception in rat.
  
  
  METHODS
  SD rats were randomly divided into electrical stimulation, control, yohimbine and naloxone group and treated with elecetrical stimulation NTS alone, or with intrathecal injection of vehicle, saline, norepinephrine a2 receptors antagonist (yohimbine), opioid receptor antagonist (naloxone) respectively.
  
  
  RESULTS
  Electrical stimulation of NTS (10, 20, 50 MA), the CMR response deceased in an intensity-dependent manner (P<0.05); intrathecal injection of vehicle, saline had no effect on the inhibition effect of electrical stimulation (P>0.05); intrathecal injection of yohimbine (20 microg, 50 microg) or naloxone (50 microg, 100 microg), reversed the inhibition effect of electrical stimulation (P<0.05); intrathecal injection of low dose of naloxone, the inhibition effect of electrical stimulation was potentiated.
  
  
  CONCLUSIONS
  Electrical stimulation of NTS has inhibition effect on cardiac nociception, norepinephrine alpha2 receptors and opioid receptor in spinal cord involved in this descending inhibition, low dose of naloxone has synergetic effect with descending inhibition.
authors: Xiao-hua
authors: XH
authors: Liu
authors: Man
authors: M
authors: Han
authors: Jian-qing
authors: JQ
authors: Du
mesh_terms: D000818:Animals; D002211:Capsaicin; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology*; D007278:Injections, Spinal; D009270:Naloxone / Q000494:pharmacology; D059225:Nociception / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex; D017552:Solitary Nucleus / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D015016:Yohimbine; D009270:Naloxone; D002211:Capsaicin