title: [Comparative study of the effects of new neuroactive amino acid derivatives on the postnatal development of the rat's offspring with experimental preeclampsia].
abstract: BACKGROUND
  Our aim was to investigate the effect of derivatives of GABA and glutamate on the postnatal development of the offspring of rats with experimental preeclampsia.
  
  
  METHODS
  The experiments were performed on 35 albino female rats aged 5-7 months, weighing 220-240 g, and their offspring in the amount of 284 individuals. Experimental preeclampsia was modeled by replacing the drinking water by 1.8% NaCl solution to pregnant females from 7 to 21 days ofgestation. Glutamic acid--compound RSPU-135 at a dose of26mg/kg, GABA derivative - compound RSPU-242 at a dose of 23 mg/kg and the reference drug sulodexide in a dose of 30 mg/kg administered to female orally daily, since the 7th day of gestation prior to delivery. Evaluated the physical development of offspring, sensory-motor reflexes, mental functions.
  
  
  RESULTS
  It was found that the experimental preeclampsia causes a delay in physical development and maturation of sensory-motor reflexes in the offspring, as indicated by the later periods of eruption of the incisors and eye opening, response to the emergence of audio and olfactory stimuli, forming vestibular stability and coordination of movements compared to pups from females with physiological pregnancy. Offspring from females with experimental preeclampsia were noted for lagging behind in mental development, as evidenced by the decline of the orienting-exploratory activity, learning and memory, increase of anxiety level. Compound RSPU-135, to a greater extent, improves physical development, increases the rate of maturation of sensory-motor reflexes, RSPU-242--stimulation of cognitive functions, keeping the memory trace, orienting-exploratory, spontaneous locomotor activity, and reduce of anxiety level.
  
  
  CONCLUSIONS
  The neuroactive amino acid derivatives limit the negative effects of experimental preeclampsia on the offspring.
authors: I N
authors: IN
authors: Tyurenkov
authors: V N
authors: VN
authors: Perfilova
authors: L I
authors: LI
authors: Mikhailova
authors: G A
authors: GA
authors: Zhakupova
authors: S A
authors: SA
authors: Lebedeva
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D018811:Maternal Exposure; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy; D051381:Rats; D012018:Reflex / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: C581791:RGPU-135; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid