title: Primary immunoglobulin repertoire development: time and space matter.
abstract: The primary immunoglobulin repertoire develops via opposing forces of expanding diversification balanced by contracting selection mechanisms. The resulting shape is essential for host health and immune fitness. While the molecular mechanisms of Ig diversification have largely been defined, selection forces shaping emerging Ig repertoires are poorly understood. During lifetime, human and mouse early B cell development occurs at distinct locations-beginning in fetal liver before transferring to bone marrow and spleen by the end of gestation. During an early life window of time, the murine gut lamina propria harbors developing immature B cells in proximity to intestinal contents such as commensal microbes and dietary antigens. Location and timing of early B cell development may thus endow neighboring antigens with primary repertoire-shaping capabilities.
authors: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors: Alessandra
authors: A
authors: Granato
authors: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
authors: Yuezhou
authors: Y
authors: Chen
authors: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: dwesemann@research.bwh.harvard.edu.
authors: Duane R
authors: DR
authors: Wesemann
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D002454:Cell Differentiation; D060966:Clonal Selection, Antigen-Mediated; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D056724:Immunity, Humoral; D007136:Immunoglobulins / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D010581:Peyer's Patches / Q000276:immunology / Q000378:metabolism
chemical_list: D000941:Antigens; D007136:Immunoglobulins