title: On the HUNT for cardiovascular risk factors and disease in patients with psoriatic arthritis: population-based data from the Nord-Trøndelag Health Study.
abstract: OBJECTIVE
  To compare the presence of cardiovascular (CV) risk factors and established CV disease in patients with psoriatic arthritis (PsA) and the general population and to compare the 10-year risk of a fatal CV event calculated by the Systematic Coronary Risk Evaluation (SCORE) algorithm.
  
  
  METHODS
  Patients with PsA (n=338) and controls (n=50 468) were recruited from the Nord-Trøndelag Health Study 3. Age-adjusted and sex-adjusted prevalence rates of CV risk factors and comorbidity were calculated and the SCORE algorithm was applied.
  
  
  RESULTS
  There was an increased prevalence of angina pectoris (5.0% vs 3.6%, p=0.01), history of percutaneous coronary intervention (2.4% vs 1.4%, p=0.04), hypertension (45.3% vs 39.3%, p=0.01), obesity (32.0% vs 22.4%) and tobacco smoking (21.3% vs 16.4%, p=0.02) in patients with PsA compared with controls. Patients with PsA had elevated levels of C reactive protein (CRP; p<0.001), body mass index (BMI; p<0.001) and triglycerides (p=0.01). The median calculated CV risk in patients with PsA was low and comparable with controls (0.87 vs 0.83, p=0.24). The distribution across CV risk classes was similar among patients with PsA and controls.
  
  
  CONCLUSIONS
  Patients with PsA have a higher risk of CV disease than the background population, although there was no difference between groups in 10-year risk of a fatal CV event estimated by SCORE. However, patients with PsA had elevated levels of CV risk factors not included in the SCORE algorithm, such as BMI, triglycerides and CRP.
authors: Department of Rheumatology, St. Olavs Hospital, Trondheim, Norway Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Agnete Malm
authors: AM
authors: Gulati
authors: Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
authors: Anne Grete
authors: AG
authors: Semb
authors: Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
authors: Silvia
authors: S
authors: Rollefstad
authors: Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Pål R
authors: PR
authors: Romundstad
authors: Department of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, California, USA.
authors: Arthur
authors: A
authors: Kavanaugh
authors: Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway Department of Neurosurgery, St. Olavs Hospital, Trondheim, Norway Norwegian Centre of Competence in Deep Brain Stimulation for Movement Disorders, Trondheim, Norway.
authors: Sasha
authors: S
authors: Gulati
authors: Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway.
authors: Glenn
authors: G
authors: Haugeberg
authors: Department of Rheumatology, St. Olavs Hospital, Trondheim, Norway Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
authors: Mari
authors: M
authors: Hoff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D015535:Arthritis, Psoriatic / Q000150:complications / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D015995:Prevalence; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: Arthritis; Cardiovascular Disease; Epidemiology; Psoriatic Arthritis