title: Family load impacts orbitofrontal volume in first-episode schizophrenia.
abstract: In schizophrenia, reduced orbitofrontal cortex (OFC) volume is inconsistently reported. To investigate the impact of genetic load on OFC volume, manual MRI-tracing in 23 first-episode schizophrenia patients (FE-SZ) and 23 controls was performed. FE-SZ with genetic load showed a decrease in OFC volume compared to FE-SZ without load and controls.
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany. Electronic address: Berend.Malchow@med.uni-muenchen.de.
authors: Berend
authors: B
authors: Malchow
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany.
authors: Alkomiet
authors: A
authors: Hasan
authors: Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany.
authors: Kristina
authors: K
authors: Meyer
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany.
authors: Thomas
authors: T
authors: Schneider-Axmann
authors: Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany.
authors: Katrin E
authors: KE
authors: Radenbach
authors: Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany.
authors: Oliver
authors: O
authors: Gruber
authors: Department of Neuroradiology, Saarland University Hospital, Kirrberger Straße, 66421 Homburg, Germany.
authors: Wolfgang
authors: W
authors: Reith
authors: Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom.
authors: Andrew M
authors: AM
authors: McIntosh
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, Rua Dr. Ovidio Pires de Campos 785, 05453-010 São Paulo, SP, Brazil.
authors: Andrea
authors: A
authors: Schmitt
authors: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany.
authors: Peter
authors: P
authors: Falkai
authors: Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany; Centre of Mental Health, County Hospitals Darmstadt-Dieburg, Krankenhausstraße 7, 64823 Groß-Umstadt, Germany.
authors: Thomas
authors: T
authors: Wobrock
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D040741:Genetic Load; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000473:pathology*; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D055815:Young Adult
keywords: First episode schizophrenia; Genetic load; Magnetic resonance imaging; Orbitofrontal cortex