title: Identification of sequence polymorphisms in the D-loop region of mitochondrial DNA as risk biomarker for liposarcoma.
abstract: Single nucleotide polymorphisms (SNPs) in the Displacement-loop (D-loop) region of mitochondrial DNA have been reported to be associated with cancer risk in various types of cancer. To assess the frequency of D-loop SNPs in a large series of liposarcoma and establish correlations with cancer risk, we sequenced the D-loop of 82 liposarcoma patients and analyzed their use as predictive biomarkers for liposarcoma risk. The minor alleles of nucleotides 73G, 523-524del, 16,290T, 16,319A, 16,356C were associated with an increased risk for liposarcoma patients, whereas the insertion of C at the site 315 (located within the D310) were associated with a decreased risk for liposarcoma patients. These results suggest that SNPs in the mitochondrial D-loop should be considered as a biomarker which may be useful for the early detection of liposarcoma in individuals at risk of this cancer.
authors: a Department of Osteology .
authors: Jianjun
authors: J
authors: Xun
authors: a Department of Osteology .
authors: Xiaolei
authors: X
authors: Song
authors: b Department of Clinical Laboratory , and.
authors: Shejun
authors: S
authors: Gao
authors: c Department of Pathology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , P.R. China.
authors: Huichai
authors: H
authors: Yang
authors: a Department of Osteology .
authors: Zhenxing
authors: Z
authors: Li
authors: a Department of Osteology .
authors: Linxing
authors: L
authors: Li
mesh_terms: D000483:Alleles; D014408:Biomarkers, Tumor / Q000235:genetics*; D016022:Case-Control Studies; D021901:DNA, Intergenic; D005260:Female; D054629:Genome, Mitochondrial; D006801:Humans; D008080:Liposarcoma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D014408:Biomarkers, Tumor; D021901:DNA, Intergenic
keywords: D-loop; SNP; liposarcoma; mtDNA