title: Maternal fish oil supplementation in pregnancy: a 12 year follow-up of a randomised controlled trial.
abstract: A number of trials have been undertaken to assess whether the intake of omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) during pregnancy can influence the neurological development of the offspring, yet no consensus from these trials has been reached. We aimed to investigate the long-term effects (12 years) of fish oil supplementation in pregnancy on neurodevelopment, including cognition, language and fine motor skills. In a follow up of a previously published randomised controlled trial of 98 pregnant women, their children were assessed at 12 years of age using a battery of neurodevelopmental assessments. Fifty participants were assessed at 12 years, with 25 participant's mothers receiving fish oil supplementation, and 25 receiving control capsules. There were no significant differences for any of the assessment measures completed. Our data indicate that fish oil supplementation during pregnancy does not influence the cognition, language or fine motor skills of children in late primary school (12 years of age).
authors: Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia. Suzanne.meldrum@uwa.edu.au.|School of Psychology and Social Science, Faculty of Health, Engineering and Science, Edith Cowan University, Joondalup 6027, Australia. Suzanne.meldrum@uwa.edu.au.
authors: Suzanne
authors: S
authors: Meldrum
authors: Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia. dunstan.jan@gmail.com.
authors: Janet A
authors: JA
authors: Dunstan
authors: Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia. jonathan.foster@uwa.edu.au.|School of Psychology and Speech Pathology, Faculty of Health Sciences, Curtin University, Bentley 6102, Australia. jonathan.foster@uwa.edu.au.
authors: Jonathan K
authors: JK
authors: Foster
authors: Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia. karen.simmer@uwa.edu.au.
authors: Karen
authors: K
authors: Simmer
authors: Centre for Neonatal Research and Education, School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Crawley 6009, Australia. susan.prescott@uwa.edu.au.|Telethon Kids Institute, University of Western Australia, Perth 6008, Australia. susan.prescott@uwa.edu.au.
authors: Susan L
authors: SL
authors: Prescott
mesh_terms: D000328:Adult; D002648:Child; D002657:Child Development / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D005500:Follow-Up Studies; D006801:Humans; D007804:Language Development; D008297:Male; D009048:Motor Skills; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils