title: Excitement about inhibitory presynaptic terminals.
abstract: Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell-deep cerebellar nuclei neuron synapses, changes in presynaptic action potential waveform substantially contribute to synaptic depression.
authors: IST Austria (Institute of Science and Technology Austria), Am Campus 1, 3400 Klosterneuburg, Austria.
authors: David H F
authors: DH
authors: Vandael
authors: IST Austria (Institute of Science and Technology Austria), Am Campus 1, 3400 Klosterneuburg, Austria.
authors: Claudia
authors: C
authors: Espinoza
authors: IST Austria (Institute of Science and Technology Austria), Am Campus 1, 3400 Klosterneuburg, Austria. Electronic address: peter.jonas@ist.ac.at.
authors: Peter
authors: P
authors: Jonas
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000502:physiology*; D011689:Purkinje Cells / Q000166:cytology*; D013569:Synapses / Q000502:physiology*