title: Multi-Center Randomized Controlled Trial on the Effect of Triclosan-Coated Sutures on Surgical Site Infection after Colorectal Surgery.
abstract: BACKGROUND
  Surgical site infection (SSI) remains the most frequent complication after colorectal resection. The role of sutures coated with antimicrobial agents such as triclosan in reducing SSI is controversial.
  
  
  METHODS
  This was a multi-center randomized controlled trial with patients and outcome assessors blinded to treatment. The study was performed in four university referral hospitals. Patient candidates for elective colorectal resection were assigned randomly to abdominal incision closure with polyglactin 910 triclosan-coated sutures (triclosan group) or with polyglactin 910 without triclosan (control group). The primary outcome was the rate of SSI within 30 d after hospital discharge. The secondary outcomes were the overall rate of incision complications and length of hospital stay (LOS).
  
  
  RESULTS
  Two hundred eighty-one patients (triclosan group: 140; control group: 141) were analyzed after randomization. The rate of SSI was 12.9% (18/140) in the triclosan group versus 10.6% (15/141) in the control group (odds ratio: 1.24; 95% confidence interval: 0.60-2.57; p=0.564). Secondary outcome analysis showed an overall incision complication rate of 38.3% in the control group versus 45.7% in the triclosan group (odds ratio: 1.36; 95% confidence interval: 0.84-2.18; p=0.208). Median LOS was 11 d in both groups (p=0.55).
  
  
  CONCLUSIONS
  Surgical sutures coated with triclosan do not appear to be effective in reducing the rate of SSI.
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Ilaria
authors: I
authors: Mattavelli
authors: 2Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, Milano-Bicocca University, Monza, Italy.
authors: Paola
authors: P
authors: Rebora
authors: 3Department of Surgery, Policlinico Gemelli, Cattolica University, Rome, Italy.
authors: Gianbattista
authors: G
authors: Doglietto
authors: 4Deparment of Surgery, Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: Paolo
authors: P
authors: Dionigi
authors: 5Department of Surgical Sciences, Ospedale Circolo Fondazione Macchi, University of Insubria, Varese, Italy.
authors: Lorenzo
authors: L
authors: Dominioni
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Margherita
authors: M
authors: Luperto
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Angela
authors: A
authors: La Porta
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Mattia
authors: M
authors: Garancini
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Luca
authors: L
authors: Nespoli
authors: 3Department of Surgery, Policlinico Gemelli, Cattolica University, Rome, Italy.
authors: Sergio
authors: S
authors: Alfieri
authors: 3Department of Surgery, Policlinico Gemelli, Cattolica University, Rome, Italy.
authors: Roberta
authors: R
authors: Menghi
authors: 4Deparment of Surgery, Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: Tommaso
authors: T
authors: Dominioni
authors: 4Deparment of Surgery, Policlinico San Matteo, University of Pavia, Pavia, Italy.
authors: Lorenzo
authors: L
authors: Cobianchi
authors: 5Department of Surgical Sciences, Ospedale Circolo Fondazione Macchi, University of Insubria, Varese, Italy.
authors: Nicola
authors: N
authors: Rotolo
authors: 5Department of Surgical Sciences, Ospedale Circolo Fondazione Macchi, University of Insubria, Varese, Italy.
authors: Gabriele
authors: G
authors: Soldini
authors: 2Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, Milano-Bicocca University, Monza, Italy.
authors: Maria Grazia
authors: MG
authors: Valsecchi
authors: 6Department of Surgery, A. Manzoni Hospital, Lecco, Italy.
authors: Marco
authors: M
authors: Chiarelli
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Angelo
authors: A
authors: Nespoli
authors: 1Department of Surgery and Translational Medicine, Milano-Bicocca University, San Gerardo Hospital, Monza, Italy.
authors: Luca
authors: L
authors: Gianotti
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D003107:Colorectal Surgery / Q000009:adverse effects* / Q000379:methods*; D004203:Disinfection / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D013536:Suture Techniques; D013537:Sutures; D016896:Treatment Outcome; D014260:Triclosan / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D014260:Triclosan