title: Tenascin-C and integrins in cancer.
abstract: Tenascin-C (TNC) is highly expressed in cancer tissues. Its cellular sources are cancer and stromal cells, including fibroblasts/myofibroblasts, and also vascular cells. TNC expressed in cancer tissues dominantly contains large splice variants. Deposition of the stroma promotes the epithelial-mesenchymal transition, proliferation, and migration of cancer cells. It also facilitates the formation of cancer stroma including desmoplasia and angiogenesis. Integrin receptors that mediate the signals of TNC have also been discussed.
authors: a Department of Pathology and Matrix Biology ; Mie University Graduate School of Medicine.
authors: Toshimichi
authors: T
authors: Yoshida
authors: Tatsuya
authors: T
authors: Akatsuka
authors: Kyoko
authors: K
authors: Imanaka-Yoshida
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D019154:Protein Splicing / Q000235:genetics / Q000502:physiology*; D019063:Tenascin / Q000378:metabolism*
chemical_list: D016023:Integrins; D019063:Tenascin
keywords: CAF, cancer-associated fibroblasts; ECM, extracellular matrix; EDA, extra domain A; EMT, epithelial-mesenchymal transition; FAK, focal adhesion kinase; FBG, fibrinogen-like globe; FN, fibronectin; FNIII, fibronectin type III-like; HS, heparan sulfate; ISH, in situ hybridization; LAP, latency-associated peptide; MMPs, matrix metalloproteinases; OPN, osteopontin; PDGF, platelet-derived growth factor; RPTP, receptor protein-tyrosine phosphatase; Stromal cell; TGF, transforming growth factor; TNC, tenascin-C; VN, vitronectin; cancer cell; integrins; splice variant; tenascin-C