title: A case of Crohn's disease that developed anti-infliximab and anti-adalimumab antibodies.
abstract: There are few reports about the rapid appearance of anti-adalimumab antibodies in patients with Crohn's disease positive for anti-infliximab antibodies. We report the case of a 29-year-old female patient with a diagnosis of Crohn's disease who revealed a loss of response to infliximab due to high levels of antibodies to infliximab, and did not respond to the subsequent therapy by adalimumab, with a rapid appearance of antibodies to adalimumab. As one of the possible mechanisms of non-response to adalimumab, immunologic reactivity of infliximab to adalimumab was suspected, since the patient's IgG that was obtained just before the induction of adalimumab reacted with infliximab and adalimumab. We should pay attention to the easy appearance of anti-adalimumab antibodies in association with reactivity of anti-infliximab antibodies to adalimumab in patients with high levels of anti-infliximab antibodies.
authors: Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa, Otsu, 520-2192, Japan.
authors: Kenichiro
authors: K
authors: Takahashi
authors: Takehide
authors: T
authors: Fujimoto
authors: Makoto
authors: M
authors: Shioya
authors: Atsushi
authors: A
authors: Nishida
authors: Shigeki
authors: S
authors: Bamba
authors: Osamu
authors: O
authors: Inatomi
authors: Hirotsugu
authors: H
authors: Imaeda
authors: Katsuyuki
authors: K
authors: Kitoh
authors: Akira
authors: A
authors: Andoh
mesh_terms: D000068879:Adalimumab / Q000276:immunology* / Q000627:therapeutic use; D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy* / Q000276:immunology*; D005260:Female; D005765:Gastrointestinal Agents / Q000276:immunology* / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D000069285:Infliximab / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D005765:Gastrointestinal Agents; D007074:Immunoglobulin G; D000069285:Infliximab; D000068879:Adalimumab