title: MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer.
abstract: Larynx cancer organ preservation treatments with chemo and radiotherapy have substantially improved laryngoesophageal dysfunction-free survival. However, both of them lead to a high incidence of acute and chronic toxicities and a significant number of patients relapse. To date, there is no evidence available to establish the group of patients that may benefit from preservation approaches and clinical criteria such as primary tumor extension or pretreatment tracheotomy are not validated. MAP17 is a small non-glycosylated membrane protein overexpressed in carcinomas. The tumoral behavior induced by MAP17 is associated with reactive oxygen species production in which SGLT1 seems involved. In this study we found that the levels of MAP17 were related to clinical findings and survival in a cohort of 58 patients with larynx cancer. MAP17 expression is associated with overall survival (p<0.001) and laryngoesophageal dysfunction-free survival (p=0.002). Locoregional control in patients with high MAP17 showed better outcomes than those with low MAP17 (p=0.016). Besides, a positive correlation was observed between MAP17 expression and SGLT (p=0.022) and the combination of high levels of MAP17/SGLT also led to an increased overall survival (p=0,028). These findings suggest that MAP17, alone or in combination with SGLT1, may become a novel predictive biomarker for laryngeal carcinoma.
authors: Department of Medical Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: María-José
authors: MJ
authors: de Miguel-Luken
authors: Department of Medical Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: Manuel
authors: M
authors: Chaves-Conde
authors: University of Málaga, Málaga, Spain.
authors: Verónica
authors: V
authors: de Miguel-Luken
authors: Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville, Spain.
authors: Sandra
authors: S
authors: Muñoz-Galván
authors: Department of Radiation Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: José Luis
authors: JL
authors: López-Guerra
authors: Department of Radiation Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: Juan C
authors: JC
authors: Mateos
authors: Department of Radiation Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: Jerónimo
authors: J
authors: Pachón
authors: Department of Pathology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: David
authors: D
authors: Chinchón
authors: Department of Radiation Oncology, Hospital Universitario Virgen del Rocío, Seville, Spain.
authors: Vladimir
authors: V
authors: Suarez
authors: Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Consejo Superior de Investigaciones Científicas, Seville, Spain.
authors: Amancio
authors: A
authors: Carnero
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D051269:Sodium-Glucose Transporter 1 / Q000032:analysis / Q000096:biosynthesis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C509768:PDZK1IP1 protein, human; C495674:SLC5A1 protein, human; D051269:Sodium-Glucose Transporter 1
keywords: MAP17; ROS; SGLT; biomarker; larynx/laryngeal cancer