title: [Apoptogenic activity of microbes-associants during Epstein-Barr virus infection].
abstract: OBJECTIVE
  Study apoptogenic activity of-microbes-associants during Epstein-Barr virus infection (EBVI) on the model of mice peritoneal macrophages in vitro.
  
  
  METHODS
  Evaluation of apoptosis induced by bacteria isolated from EBVI patients was carried out by characteristic morphological changes of macrophages in smears stained by May-Grunwald with additional staining by Romanowsky-Giemsa.
  
  
  RESULTS
  All the EBVI microbes-associants were established to have apoptogenic activity, however, the highest pathogenic potential was noted in Streptococcus pyogenes.
  
  
  CONCLUSIONS
  The presence of apoptogenic activity in bacterial microflora accompanying EBVI against immune system cells could serve as means of their survival and be the pathogenetic basis for prolonged persistence in the organism.
authors: M A
authors: MA
authors: Kim
authors: É N
authors: ÉN
authors: Simovanian
authors: É L
authors: ÉL
authors: Alutina
authors: G G
authors: GG
authors: Kharseeva
mesh_terms: D000293:Adolescent; D000818:Animals; D017209:Apoptosis; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000382:microbiology* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D017737:Macrophages, Peritoneal / Q000382:microbiology*; D008297:Male; D051379:Mice; D008853:Microscopy; D009061:Mouth Mucosa / Q000276:immunology / Q000382:microbiology* / Q000821:virology; D061251:Primary Cell Culture; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity; D013211:Staphylococcus aureus / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity; D013212:Staphylococcus epidermidis / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity; D013297:Streptococcus pyogenes / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity*; D034363:Viridans Streptococci / Q000254:growth & development / Q000302:isolation & purification / Q000472:pathogenicity