title: Palladium-catalyzed Csp(2)-H carbonylation of aromatic oximes: selective access to benzo[d][1,2]oxazin-1-ones and 3-methyleneisoindolin-1-ones.
abstract: A highly selective palladium-catalyzed carbonylation of Csp(2)-H bonds with aromatic oximes for the synthesis of benzo[d][1,2]oxazin-1-ones and 3-methyleneisoindolin-1-ones has been developed. Interestingly, we found that the N-OH group of the oximes could be used as a directing group and/or an internal oxidant under different conditions. This transformation is supposed to proceed through a hydroxyl-directed ortho-Csp(2)-H carbonylation or activation of vinyl Csp(2)-H bond/ortho-Csp(2)-H carbonylation process. The uses of readily available starting materials, atmospheric pressure of carbon monoxide, as well as operational simplicity make this practical and atom-economical method particularly attractive.
authors: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. jianghf@scut.edu.cn.
authors: Yanli
authors: Y
authors: Xu
authors: Weigao
authors: W
authors: Hu
authors: Xiaodong
authors: X
authors: Tang
authors: Jinwu
authors: J
authors: Zhao
authors: Wanqing
authors: W
authors: Wu
authors: Huanfeng
authors: H
authors: Jiang