title: Acute effect of hemodialysis on arterial elasticity.
abstract: OBJECTIVE
  Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD.
  
  
  METHODS
  In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations.
  
  
  RESULTS
  At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 ± 2.6 mL/mmHg x 100) than in healthy individuals (8.9 ± 3.4 mL/mmHg x 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 ± 2.6 mL/mmHg x 100 to 3.4 ± 2.3, P < 0.05).
  
  
  CONCLUSIONS
  We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.
authors: Saim
authors: S
authors: Sağ
authors: Dilek
authors: D
authors: Yeşilbursa
authors: Abdulmecit
authors: A
authors: Yildiz
authors: Kamil
authors: K
authors: Dilek
authors: Tunay
authors: T
authors: Şentürk
authors: Osman Akın
authors: OA
authors: Serdar
authors: Ali
authors: A
authors: Aydinlar
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology*; D016022:Case-Control Studies; D004548:Elasticity / Q000502:physiology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D006435:Renal Dialysis