title: Effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice.
abstract: Probiotics have been shown to have a preventative effect on skin photoaging induced by short term UV irradiation, however, the underlying mechanisms and the effect of probiotics on skin photoaging induced by chronic UV irradiation remain unclear. In this study, we investigated the effect of Bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in hairless mice. Mice were irradiated with UVB three times weekly and orally administered B. breve B-3 (2×10(9) cfu/mouse /day) for 7 weeks. Nonirradiated mice and UVB-irradiated mice without probiotic treatment were used as controls. B. breve B-3 significantly suppressed the changes of transepidermal water loss, skin hydration, epidermal thickening and attenuated the damage to the tight junction structure and basement membrane induced by chronic UVB irradiation. Administration of B. breve B-3 tended to suppress the UV-induced interleukin-1β production in skin (P=0.09). These results suggest that B. breve B-3 could potentially be used to prevent photoaging induced by chronic UV irradiation.
authors: 1 Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd., 1-83, 5-Chome, Higashihara, 228-8583 Zama-City, Kanagawa-Pref, Japan.
authors: T
authors: T
authors: Satoh
authors: M
authors: M
authors: Murata
authors: N
authors: N
authors: Iwabuchi
authors: T
authors: T
authors: Odamaki
authors: H
authors: H
authors: Wakabayashi
authors: K
authors: K
authors: Yamauchi
authors: F
authors: F
authors: Abe
authors: J Z
authors: JZ
authors: Xiao
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000254:growth & development*; D053583:Interleukin-1beta / Q000032:analysis; D008297:Male; D008812:Mice, Hairless; D019936:Probiotics / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology* / Q000528:radiation effects*; D015595:Skin Aging / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D053583:Interleukin-1beta
keywords: Bifidobacterium breve; chronic UV irradiation; photoaging; skin barrier