title: Iridium-catalyzed chemoselective reductive nucleophilic addition to N-methoxyamides.
abstract: Iridium-catalyzed reductive nucleophilic addition to N-methoxyamides is reported. The reaction took place in high yields in the presence of a variety of sensitive functional groups such as esters and nitro groups. Mechanistic studies revealed that the reaction of N-methoxyamides proceeded without equilibrium to an enamine intermediate in contrast to that with tert-amides.
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors: Minami
authors: M
authors: Nakajima
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors: Takaaki
authors: T
authors: Sato
authors: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
authors: Noritaka
authors: N
authors: Chida
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D004952:Esters; D007495:Iridium