title: Quality of Life after Endoluminal Loco-Regional Resection (ELRR) by Transanal Endoscopic Microsurgery (TEM).
abstract: OBJECTIVE
  Endoluminal Loco-Regional Resection (ELRR) by Transanal Endoscopic Microsurgery (TEM) may be considered a valid alternative surgical treatment in patients with rectal cancer. Aim of this study is to evaluate the short and medium term Quality of Life (QoL) from prospectively collected data in patients who underwent ELRR by TEM.
  
  
  METHODS
  From May 2010 to June 2013, 31 patients with iT1-iT2-iT3N0 rectal cancer were enrolled in this study. Patients with T1 rectal cancer underwent ELRR by TEM. Patients with iT2-iT3 rectal cancer underwent neoadjuvant radio-chemoterapy (n-RCT) before surgery. QoL was evaluated by EORTC QLQ-C30 and QLQ-CR38 questionnaires before surgery and 1, 6, and 12 months after surgery.
  
  
  RESULTS
  Mean distance from the anal verge was 5.4 cm (range 1-10). Mean operative time was 145.8 minutes (range 60-300). Pathological staging was as follows: pT0N0 (6), pT1N0 (18), pT2N0 (7). At 1 month after surgery, in QLQC30 questionnaire, significant worsening was observed in Global Health Status (p=0.0028), Physical Functioning (p=0.0016), Role Functioning (p=0.0004), Fatigue (p=0.0024), Pain (p=0.0003) and Dyspnoea (p=0.0192). In QLQCR38 questionnaire significant worsening at 1 month was observed in Defecation Problems (p=0.0005) and Weight Loss (p=0.0008). At six and twelve months after surgery, no significant differences were observed in QLQ-C30 and in QLQCR38 questionnaires.
  
  
  CONCLUSIONS
  QoL evaluation showed worsening results at 1 month after ELRR by TEM, in QLQ-C30 and in QLQCR38 questionnaires.
  
  
  CONCLUSIONS
  At 6 and 12 months after surgery, no significant differences in QoL as compared to preoperative status were observed.
authors: Giancarlo
authors: G
authors: D'Ambrosio
authors: Andrea
authors: A
authors: Balla
authors: Fabrizio
authors: F
authors: Mattei
authors: Silvia
authors: S
authors: Quaresima
authors: Francesca
authors: F
authors: De Laurentis
authors: Alessandro M
authors: AM
authors: Paganini
mesh_terms: D000230:Adenocarcinoma / Q000523:psychology / Q000601:surgery* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D059248:Chemoradiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications / Q000453:epidemiology / Q000523:psychology; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000523:psychology / Q000601:surgery* / Q000628:therapy; D011795:Surveys and Questionnaires; D013997:Time Factors; D000067369:Transanal Endoscopic Microsurgery / Q000523:psychology*; D016896:Treatment Outcome