title: Impact of osteopathic manipulative therapy on quality of life of patients with deep infiltrating endometriosis with colorectal involvement: results of a pilot study.
abstract: OBJECTIVE
  A prospective pilot study to evaluate the potential role of osteopathic manipulative therapy (OMT) on quality of life (QOL) of patients with Deep Infiltrating Endometriosis (DIE) and colorectal involvement.
  
  
  METHODS
  Twenty patients with DIE and colorectal infiltration completed the SF-36 QOL questionnaire before and after undergoing OMT.
  
  
  RESULTS
  The median age (range) of the patients was 30.4 years (22-39). Thirty-five percent of the patients had undergone previous surgery for endometriosis and 70% were on medical treatment. Fifteen of the 20 patients (75%) completed the protocol. There was no difference in the epidemiological characteristics or in the pre-OMT Physical Component Summary (PCS) and Mental Component Summary (MCS) of the SF-36 questionnaire between patients who completed the protocol or not. After a mean period of 24 days (15-53), a significant improvement in PCS (p=0.03) and MCS (p=0.0009) compared to pre-OMT values was observed giving a success rate of 80% and 60% in intention-to-treat, respectively.
  
  
  CONCLUSIONS
  Our results support that OMT can improve QOL of patients with DIE and colorectal involvement. Moreover, this pilot study can serve to determine power calculations for future randomized trials.
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France; Institut Privé d'Enseignement Ostéopathique (IPEO), 5/13 rue Auger, Pantin, France.
authors: Camille
authors: C
authors: Daraï
authors: Institut Privé d'Enseignement Ostéopathique (IPEO), 5/13 rue Auger, Pantin, France.
authors: Olivier
authors: O
authors: Deboute
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France.
authors: Chrysoula
authors: C
authors: Zacharopoulou
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France.
authors: Enora
authors: E
authors: Laas
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France.
authors: Geoffroy
authors: G
authors: Canlorbe
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France.
authors: Jéremie
authors: J
authors: Belghiti
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France.
authors: Sonia
authors: S
authors: Zilberman
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France; UMRS938, Université Pierre et Marie Curie, Paris 6, France.
authors: Marcos
authors: M
authors: Ballester
authors: Service de Gynécologie-Obstétrique et Reproduction Humaine, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris 6, GRC-6 UPMC, Centre Expert En Endométriose (C3E), Paris, France; UMRS938, Université Pierre et Marie Curie, Paris 6, France. Electronic address: emile.darai@tnn.aphp.fr.
authors: Emile
authors: E
authors: Daraï
mesh_terms: D000328:Adult; D003108:Colonic Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D004715:Endometriosis / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D057194:Intention to Treat Analysis; D008279:Magnetic Resonance Imaging; D026301:Manipulation, Osteopathic; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D012002:Rectal Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D011795:Surveys and Questionnaires; D014463:Ultrasonography; D055815:Young Adult
keywords: Colorectal endometriosis; Deep infiltrating endometriosis; Endometriosis; Osteopathic manipulative therapy; Quality of life; SF-36