title: Hierarchical analysis and multi-scale modelling of rat cortical and trabecular bone.
abstract: The aim of this study was to explore the hierarchical arrangement of structural properties in cortical and trabecular bone and to determine a mathematical model that accurately predicts the tissue's mechanical properties as a function of these indices. By using a variety of analytical techniques, we were able to characterize the structural and compositional properties of cortical and trabecular bones, as well as to determine the suitable mathematical model to predict the tissue's mechanical properties using a continuum micromechanics approach. Our hierarchical analysis demonstrated that the differences between cortical and trabecular bone reside mainly at the micro- and ultrastructural levels. By gaining a better appreciation of the similarities and differences between the two bone types, we would be able to provide a better assessment and understanding of their individual roles, as well as their contribution to bone health overall.
authors: Center for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
authors: Ramin
authors: R
authors: Oftadeh
authors: Center for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors: Vahid
authors: V
authors: Entezari
authors: Center for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
authors: Guy
authors: G
authors: Spörri
authors: Center for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
authors: Juan C
authors: JC
authors: Villa-Camacho
authors: Department of Orthopaedics, University of California, San Francisco, CA, USA.
authors: Henry
authors: H
authors: Krigbaum
authors: Laboratory for the Study of Skeletal Disorders and Rehabilitation, Boston Children's Hospital, Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, USA.
authors: Elsa
authors: E
authors: Strawich
authors: Laboratory for the Study of Skeletal Disorders and Rehabilitation, Boston Children's Hospital, Department of Orthopaedic Surgery, Harvard Medical School, Boston, MA, USA.
authors: Lila
authors: L
authors: Graham
authors: Centre Inter Universitaire de Recherche et d'Ingénierie des Matériaux, Ecole Nationale Supérieure des Ingénieurs en Arts Chimiques et Technologiques, Toulouse, France.
authors: Christian
authors: C
authors: Rey
authors: Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA.
authors: Hank
authors: H
authors: Chiu
authors: Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
authors: Ralph
authors: R
authors: Müller
authors: Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
authors: Hamid Nayeb
authors: HN
authors: Hashemi
authors: Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
authors: Ashkan
authors: A
authors: Vaziri
authors: Center for Advanced Orthopaedic Studies, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA anazaria@bidmc.harvard.edu.
authors: Ara
authors: A
authors: Nazarian
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005260:Female; D005269:Femur / Q000502:physiology* / Q000648:ultrastructure*; D006244:Hardness / Q000502:physiology; D008953:Models, Anatomic; D008954:Models, Biological; D051381:Rats; D017207:Rats, Sprague-Dawley; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology
keywords: bone composition and structure; bone mechanical properties; continuum micromechanics; cortical and trabecular bone; hierarchical analysis