title: Evaluation of the anti-inflammatory effects of peri-operative infusion of magnesium sulfate on the microsurgical procedures for intracranial tumors.
abstract: BACKGROUND
  The anti-inflammatory properties of magnesium sulfate have never been discussed in brain tumor surgeries.
  
  
  OBJECTIVE
  This study is aimed to find anti-inflammatory aspects of high dose magnesium sulfate infusion during perioperative period of neurosurgical patients through checking the serial C-reactive protein (CRP) blood levels as a biomarker of inflammation.
  
  
  METHODS
  Sixty patients who were candidate for elective craniotomy were enrolled randomly into two equal groups to receive either magnesium sulfate or normal saline during their perioperative period. Infusion of magnesium was performed three times during the study and a summation of 15 grams was administered: 1- two days before surgery, 2- one day before surgery, 3- from the beginning of surgery (five grams was infused within six hours in each session). Serum level of CRP was checked just before commencement of magnesium infusion and on the first and second day after surgery as primary outcome. Hemodynamic parameters, total propofol requirement and total blood loss were recorded as well.
  
  
  RESULTS
  No significant difference was found between groups in terms of serum CRP levels. The mean arterial blood pressure, heart rate, blood loss and total anesthetic requirement were significantly lower in magnesium group in comparison to the control group.
  
  
  CONCLUSIONS
  We did not find conclusive evidence for anti-inflammatory effects of magnesium in craniotomy for microsurgery of intracranial tumors using CRP level changes. However, high dose magnesium might be suggested as a safe anesthetic adjuvant in neurosurgery.
authors: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Farhad
authors: F
authors: Etezadi
authors: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Majid
authors: M
authors: Aklamli
authors: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Atabak
authors: A
authors: Najafi
authors: Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammadreza
authors: M
authors: Khajavi
authors: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Shariat Moharari
authors: Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Teheran, Iran.
authors: Bahador
authors: B
authors: Mirrahimi
authors: Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Seyed Abolghasem
authors: SA
authors: Mortazavi
authors: Pharmaceutical Sciences Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Teheran, Iran.
authors: Mojtaba
authors: M
authors: Mojtahedzadeh
keywords: Brain Tumor; C - reactive protein; Magnesium Sulfate; Surgery