title: Rhabdomyolysis Occurring under Statins after Intense Physical Activity in a Marathon Runner.
abstract: Statins are widely used in the treatment of hypercholesterolemia and their side effects on muscles are well established. Conversely, data are sparse regarding the safety of this class of drugs in subjects who engage in sports, particularly those who have intense sports activity. We report the case of a marathon runner who presented with acute rhabdomyolysis during competition while being under rosuvastatin treatment. This case raises the question of the need for temporary discontinuation of statin therapy when intense physical activity is planned.
authors: Clinical Investigation Center for Biotherapy, CIC-1431, FHU INCREASE, University Hospital of Besançon, 25000 Besançon, France ; Department of Rheumatology, University Hospital of Besançon, 25000 Besançon, France ; Department of Therapeutics and EA 4266 "Pathogens and Inflammation", SFR FED 4234, University of Franche-Comté, 25000 Besançon, France.
authors: Éric
authors: É
authors: Toussirot
authors: Department of Sport Medicine, University Hospital of Besançon, 25000 Besançon, France.
authors: Fabrice
authors: F
authors: Michel
authors: Department of Cardiology, University Hospital of Besançon, 25000 Besançon, France ; EA3920 "Marqueurs Pronostiques et Facteurs de Régulation des Pathologies Cardiaques et Vasculaires" SFR FED 4234, University of Franche-Comté, 25000 Besançon, France.
authors: Nicolas
authors: N
authors: Meneveau