title: Evaluation of autoinflammatory disease genes in nasal polyposis.
abstract: OBJECTIVE
  To investigate cold-induced autoinflammatory syndrome 1 (CIAS 1) gene polymorphisms that cause autoinflammatory diseases in patients with nasal polyposis (NP).
  
  
  METHODS
  The study included 30 patients diagnosed with NP and 30 healthy age-matched individuals as a control group. CIAS1 polymorphisms were assessed by DNA sequence analysis. Patients with nasal polyps and the control group were compared in terms of gene polymorphisms. Each of the 8 polymorphisms of the CIAS1 gene was analyzed separately in the patient group.
  
  
  RESULTS
  The most frequently observed polymorphisms in the patient group were c.732G > A in 83%, c.663C > T in 23%, and c.1308C > A in 23% of the patients. c.732G > A polymorphism was evaluated separately. Guanine was transformed to adenine at the 732nd nucleotide position of the CIAS1 gene in the cDNA of chromosome 1.
  
  
  CONCLUSIONS
  The CIAS1 gene c.732G > A polymorphism was thought to be responsible for an increase in disease susceptibility. The frequency of the "A" allele is higher in the patient group compared to the control group. Autoinflammatory diseases seem like a candidate to be one of these factors. This is the first report to define the role of autoinflammatory diseases among these factors.
authors: Sabri
authors: S
authors: Köseoğlu
authors: Kürşat Murat
authors: KM
authors: Özcan
authors: Aykut
authors: A
authors: İkincioğullari
authors: Mehmet Ali
authors: MA
authors: Cetin
authors: Talih
authors: T
authors: Özdaş
authors: Sibel
authors: S
authors: Özdaş
authors: Serdar
authors: S
authors: Ensari
authors: Hacı Hüseyin
authors: HH
authors: Dere
mesh_terms: D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D056660:Hereditary Autoinflammatory Diseases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009298:Nasal Polyps / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human