title: Challenges and Potential for Ovarian Preservation with SERMs.
abstract: Tamoxifen (TAM) is a selective estrogen receptor modulator with tissue-specific effects on estrogen signaling used predominantly for treatment and chemoprevention of breast cancers. Recent studies have shown that TAM prevents infertility and decreases follicular loss from common cancer chemotherapy and radiation therapy in preclinical models. Here we review current and novel uses of selective estrogen receptor modulator s and advantages and challenges for translation of TAM for human fertility preservation.
authors: Division of Reproduction and Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon.
authors: Alison Y
authors: AY
authors: Ting
authors: Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan bpetroff@msu.edu.
authors: Brian K
authors: BK
authors: Petroff
mesh_terms: D005260:Female; D005298:Fertility / Q000187:drug effects; D006801:Humans; D010053:Ovary / Q000187:drug effects*; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen
keywords: SERM; cancer; fertility; ovary; tamoxifen