title: Negative impact of manganese on honeybee foraging.
abstract: Anthropogenic accumulation of metals such as manganese is a well-established health risk factor for vertebrates. By contrast, the long-term impact of these contaminants on invertebrates is mostly unknown. Here, we demonstrate that manganese ingestion alters brain biogenic amine levels in honeybees and fruit flies. Furthermore, we show that manganese exposure negatively affects foraging behaviour in the honeybee, an economically important pollinator. Our findings indicate that in addition to its direct impact on human health, the common industrial contaminant manganese might also have indirect environmental and economical impacts via the modulation of neuronal and behavioural functions in economically important insects.
authors: Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2122, Australia.
authors: Eirik
authors: E
authors: Søvik
authors: Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2122, Australia.
authors: Clint J
authors: CJ
authors: Perry
authors: Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA.
authors: Angie
authors: A
authors: LaMora
authors: Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2122, Australia.
authors: Andrew B
authors: AB
authors: Barron
authors: Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA benshahary@wustl.edu.
authors: Yehuda
authors: Y
authors: Ben-Shahar
mesh_terms: D000818:Animals; D001516:Bees / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001679:Biogenic Amines / Q000378:metabolism / Q000502:physiology*; D001923:Brain Chemistry / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology; D004785:Environmental Pollutants / Q000633:toxicity*; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D008345:Manganese / Q000633:toxicity*
chemical_list: D001679:Biogenic Amines; D004785:Environmental Pollutants; D008345:Manganese
keywords: Apis mellifera; Drosophila melanogaster; biogenic amines; dopamine; fruit fly