title: Electrical and electrochemical monitoring of nucleic Acid amplification.
abstract: Nucleic acid amplification is a gold standard technique for analyzing a tiny amount of nucleotides in molecular biology, clinical diagnostics, food safety, and environmental testing. Electrical and electrochemical monitoring of the amplification process draws attention over conventional optical methods because of the amenability toward point-of-care applications as there is a growing demand for nucleic acid sensing in situations outside the laboratory. A number of electrical and electrochemical techniques coupled with various amplification methods including isothermal amplification have been reported in the last 10 years. In this review, we highlight recent developments in the electrical and electrochemical monitoring of nucleic acid amplification.
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.
authors: Tatsuro
authors: T
authors: Goda
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.
authors: Miyuki
authors: M
authors: Tabata
authors: Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU) , Tokyo , Japan.
authors: Yuji
authors: Y
authors: Miyahara
keywords: PCR; electrical biosensor; field-effect transistor; isothermal amplification; pH monitoring