title: Severity of influenza A(H1N1) illness and emergence of D225G variant, 2013-14 influenza season, Florida, USA.
abstract: Despite a regional decline in influenza A(H1N1)pdm09 virus infections during 2013-14, cases at a Florida hospital were more severe than those during 2009-10. Examined strains had a hemagglutinin polymorphism associated with enhanced binding to lower respiratory tract receptors. Genetic changes in this virus must be monitored to predict the effect of future pandemic viruses.
authors: Nicole M
authors: NM
authors: Iovine
authors: J Glenn
authors: JG
authors: Morris
authors: Kristianna
authors: K
authors: Fredenburg
authors: Kenneth
authors: K
authors: Rand
authors: Hassan
authors: H
authors: Alnuaimat
authors: Gloria
authors: G
authors: Lipori
authors: Joseph
authors: J
authors: Brew
authors: John A
authors: JA
authors: Lednicky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D005260:Female; D005431:Florida / Q000453:epidemiology; D014644:Genetic Variation; D049674:History, 21st Century; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000453:epidemiology* / Q000266:history / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009026:Mortality; D012621:Seasons; D055815:Young Adult
keywords: D225G polymorphism; Florida; H1N1 subtype; acute respiratory distress syndrome; genetic changes; hemagglutinin; influenza; influenza virus; pandemic; respiratory tract disease; sialic acid; viruses