title: Antiapoptotic Bcl-2 protein as a potential target for cancer therapy: A mini review.
abstract: Bcl-2, an antiapoptotic protein, is considered as a potential target in cancer treatment since its oncogenic potential has been proven and is well documented. Antisense technology and RNA interference (RNAi) have been used to reduce the expression of the Bcl-2 gene in many types of cancer cells and are effective as adjuvant therapy along with the chemotherapeutic agents. The lack of appropriate delivery systems is considered to be the main hurdle associated with the RNAi. In this review, we discuss the antiapoptotic Bcl-2 protein, its oncogenic potential, and various approaches utilized to target Bcl-2 including suitable delivery systems employed for successful delivery of siRNA.
authors: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors: Hitesh
authors: H
authors: Jagani
authors: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors: Narayanan
authors: N
authors: Kasinathan
authors: b Department of Pharmaceutics , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors: Sreenivasa Reddy
authors: SR
authors: Meka
authors: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors: Venkata Rao
authors: VR
authors: Josyula
mesh_terms: D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D034622:RNA Interference; D034741:RNA, Small Interfering
chemical_list: C000595707:BCL2 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D034741:RNA, Small Interfering
keywords: Antisense oligonucleotide; Bcl-2; RNA interference; apoptosis; cancer; drug delivery