title: Surgical treatment for mono-segmental lumbar tuberculosis by single-stage posterior debridement, compact bone grafting and posterior single-segment ﬁxation.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of single-stage posterior debridement, compact bone grafting and posterior single-segment fixation for the treatment of mono-segmental lumbar tuberculosis.
  
  
  METHODS
  We enrolled 32 patients with mono-segmental lumbar tuberculosis from January 2005 to April 2011. The severity of damage to the vertebral bodies is not more than 2/3 height. All the patients were treated by single-stage posterior debridement, compact bone grafting and posterior single-segment fixation.
  
  
  RESULTS
  Patients were followed 21-63 months (43.5±9.5 months). The average Cobb angle decreased to 5.3±3.0° postoperatively from 22.1±6.1° preoperatively. Meanwhile, average 1.8±1.0° loss was observed at last visit. Fusion occurred at 3-9 months (mean 5.1 months). All patients with preoperative neurologic deficit recovered in different degree. 1 with grade B recovered to grade D; 2 with grade C recovered to grade E; 18 with grade D recovered to grade E. No mortality occurred. One patient experienced anti-tuberculosis drug-induced liver dysfunction which was managed successfully with modified anti-TB treatment and hepato-protective treatment. The Oswestry Disability Index decreased from 40.1±4.0 preoperatively to 13.7±3.1 postoperatively.
  
  
  CONCLUSIONS
  Single-stage posterior debridement, compact bone grafting and posterior single-segment fixation is an effective method for the treatment of mono-segmental lumbar tuberculosis.
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: xzqdoc@163.com.
authors: Zhengquan
authors: Z
authors: Xu
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: wxyxydoc@163.com.
authors: Xiyang
authors: X
authors: Wang
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: 1615316345@qq.com.
authors: Ping
authors: P
authors: Wu
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: 523631750@qq.com.
authors: Xiaoyang
authors: X
authors: Pang
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: xyyyxyp@163.com.
authors: Chengke
authors: C
authors: Luo
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: xiangyajzwk@163.com.
authors: Penghui
authors: P
authors: Zhang
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: xiangjzwk@163.com.
authors: Hao
authors: H
authors: Zeng
authors: Department of Spine Surgery, the Xiangya Hospital of Central South University, 87# Xiangya Road, Changsha, Hunan 410008, People's Republic of China. Electronic address: xyjzwk@163.com.
authors: Wei
authors: W
authors: Peng
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001863:Bone Screws; D016025:Bone Transplantation / Q000379:methods; D002681:China / Q000453:epidemiology; D003646:Debridement / Q000379:methods; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal / Q000379:methods; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D011184:Postoperative Period; D017410:Practice Guidelines as Topic; D011859:Radiography; D013123:Spinal Fusion / Q000379:methods; D016896:Treatment Outcome; D014399:Tuberculosis, Spinal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*
chemical_list: D000995:Antitubercular Agents
keywords: Compact bone grafting; Mono-segmental lumbar tuberculosis; Posterior debridement; Single-segment ﬁxation; Surgical treatment