title: Vasculoplacental complications in pregnant women with HIV infection: a case-control study.
abstract: OBJECTIVE
  Data from the international literature suggest that there may be an association between maternal human immunodeficiency virus (HIV) infection and vasculoplacental complications during pregnancy. Studies on this subject have reached discordant conclusions. The aim of this study was to assess the incidence of vasculoplacental complications during pregnancy in women with and without HIV infection.
  
  
  METHODS
  This single-center case-control study compared the incidence of pregnancy-related hypertension, preeclampsia, eclampsia, and vascular intrauterine growth restriction in 280 women with HIV and 560 women not infected with HIV, matched for age, parity, and geographic origin.
  
  
  RESULTS
  The incidence rates of pregnancy-related hypertension, preeclampsia, eclampsia, and vascular growth restriction did not differ between the women with and without HIV infection. The overall incidence of vasculoplacental complications did not differ between the 2 groups (7.5% vs 9.8%, respectively; P = .27). The risk of these was not associated with exposure to antiretroviral treatments, viral load, or CD4 T-cell counts at the beginning of pregnancy.
  
  
  CONCLUSIONS
  This study shows no difference in the incidence of vasculoplacental complications between women with and without HIV infection.
authors: Department of Gynecology and Obstetrics, Hôpital Bichat-Claude Bernard, Université Paris Diderot, Paris, France; Hospital and University Departments of Risk in Pregnancy, Paris, France.
authors: Geoffroy
authors: G
authors: Canlorbe
authors: Department of Infectious and Tropical Infections, Hôpital Bichat-Claude Bernard, Université Paris Diderot, Paris, France; Infection, Antimicrobials, Modeling, and Evolution Unité Mixte de Recherche 1137, French Institute of Health and Medical Research, Paris, France.
authors: Sophie
authors: S
authors: Matheron
authors: Hospital and University Departments of Risk in Pregnancy, Paris, France; Department of Gynecology and Obstetrics, Assistance Publique-Hôpitaux de Paris Hôpital Louis Mourier, Colombes, France.
authors: Laurent
authors: L
authors: Mandelbrot
authors: Department of Gynecology and Obstetrics, Hôpital Bichat-Claude Bernard, Université Paris Diderot, Paris, France; Hospital and University Departments of Risk in Pregnancy, Paris, France.
authors: Barbara
authors: B
authors: Oudet
authors: Department of Gynecology and Obstetrics, Hôpital Bichat-Claude Bernard, Université Paris Diderot, Paris, France; Hospital and University Departments of Risk in Pregnancy, Paris, France.
authors: Dominique
authors: D
authors: Luton
authors: Department of Gynecology and Obstetrics, Hôpital Bichat-Claude Bernard, Université Paris Diderot, Paris, France; Hospital and University Departments of Risk in Pregnancy, Paris, France; Obstetric, Perinatal, and Pediatric Epidemiology Team, Epidemiology and Biostatistics Center, Institute of Health and Medical Research Unité 1153, Sorbonne Paris Cité Center, Paris, France. Electronic address: eazria@hpsj.fr.
authors: Elie
authors: E
authors: Azria
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes; D016022:Case-Control Studies; D004461:Eclampsia / Q000453:epidemiology; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology*; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D010927:Placental Insufficiency / Q000453:epidemiology*; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D012367:RNA, Viral / Q000097:blood*; D012307:Risk Factors; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging; D019562:Viral Load; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral
keywords: antiretroviral therapy; human immunodeficiency virus; ischemic placental disease; low birthweight; preeclampsia; pregnancy-related hypertension