title: Adult stem cells in neural repair: Current options, limitations and perspectives.
abstract: Stem cells represent a promising step for the future of regenerative medicine. As they are able to differentiate into any cell type, tissue or organ, these cells are great candidates for treatments against the worst diseases that defy doctors and researchers around the world. Stem cells can be divided into three main groups: (1) embryonic stem cells; (2) fetal stem cells; and (3) adult stem cells. In terms of their capacity for proliferation, stem cells are also classified as totipotent, pluripotent or multipotent. Adult stem cells, also known as somatic cells, are found in various regions of the adult organism, such as bone marrow, skin, eyes, viscera and brain. They can differentiate into unipotent cells of the residing tissue, generally for the purpose of repair. These cells represent an excellent choice in regenerative medicine, every patient can be a donor of adult stem cells to provide a more customized and efficient therapy against various diseases, in other words, they allow the opportunity of autologous transplantation. But in order to start clinical trials and achieve great results, we need to understand how these cells interact with the host tissue, how they can manipulate or be manipulated by the microenvironment where they will be transplanted and for how long they can maintain their multipotent state to provide a full regeneration.
authors: Eric Domingos Mariano, Suely Kazue Nagahashi Marie, Guilherme Lepski, Department of Neurology, Medicine School, University of São Paulo, São Paulo SP 01246-903, Brazil.
authors: Eric Domingos
authors: ED
authors: Mariano
authors: Eric Domingos Mariano, Suely Kazue Nagahashi Marie, Guilherme Lepski, Department of Neurology, Medicine School, University of São Paulo, São Paulo SP 01246-903, Brazil.
authors: Manoel Jacobsen
authors: MJ
authors: Teixeira
authors: Eric Domingos Mariano, Suely Kazue Nagahashi Marie, Guilherme Lepski, Department of Neurology, Medicine School, University of São Paulo, São Paulo SP 01246-903, Brazil.
authors: Suely Kazue Nagahashi
authors: SK
authors: Marie
authors: Eric Domingos Mariano, Suely Kazue Nagahashi Marie, Guilherme Lepski, Department of Neurology, Medicine School, University of São Paulo, São Paulo SP 01246-903, Brazil.
authors: Guilherme
authors: G
authors: Lepski
keywords: Adult stem cells; Bone marrow stem cells; Mesenchymal stem cells; Neural stem cells; Olfactory ensheathing cells; Stem cell therapy; Stem cells