title: Myelodysplastic syndrome with clonal cytogenetic abnormalities followed by fatal erythroid leukemia after 14 years of exposure to hydroxyurea for sickle cell anemia.
authors: Service D'hématologie Biologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.
authors: Cédric
authors: C
authors: Aumont
authors: Service De Médecine Interne Et Immunologie Clinique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.
authors: Françoise
authors: F
authors: Driss
authors: Service D'anatomie Pathologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre, Cedex, France.
authors: Thierry
authors: T
authors: Lazure
authors: Service D'hématologie Biologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.
authors: Véronique
authors: V
authors: Picard
authors: Service D'hématologie Biologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.
authors: Rita
authors: R
authors: Creidy
authors: Service D'hématologie, Gustave Roussy, Villejuif Cedex, France.|Université Paris Sud 11, Le Kremlin-Bicêtre, Cedex, France.
authors: Stéphane
authors: S
authors: De Botton
authors: Laboratoire D'hématologie, Gustave, Roussy, Villejuif Cedex, France.
authors: Véronique
authors: V
authors: Saada
authors: Service De Médecine Interne Et Immunologie Clinique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.|Université Paris Sud 11, Le Kremlin-Bicêtre, Cedex, France.
authors: Olivier
authors: O
authors: Lambotte
authors: Service D'hématologie Biologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.
authors: Chrystèle
authors: C
authors: Bilhou-Nabera
authors: Service D'hématologie Biologique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.|Université Paris Sud 11, Le Kremlin-Bicêtre, Cedex, France.
authors: Gérard
authors: G
authors: Tertian
authors: Service De Médecine Interne Et Immunologie Clinique, Assistance Publique-Hôpitaux De Paris, Hôpital Universitaire Bicêtre, Le Kremlin Bicêtre Cedex, France.|Service D'hématologie, Gustave Roussy, Villejuif Cedex, France.
authors: Jean-Marie
authors: JM
authors: Michot
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000986:Antisickling Agents / Q000627:therapeutic use*; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17; D002895:Chromosomes, Human, Pair 5; D002999:Clone Cells; D004900:Erythroblasts / Q000378:metabolism / Q000473:pathology; D017809:Fatal Outcome; D042381:Granulocyte Precursor Cells / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D059785:Karyotype; D004915:Leukemia, Erythroblastic, Acute / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D000986:Antisickling Agents; D006918:Hydroxyurea