title: Proteins involved in more domain types tend to be more essential.
abstract: Investigation of essential proteins is significantly valuable for understanding of cellular life, drug design and other practical purposes. In most of current studies, essential proteins are generally mined in protein-protein interaction (PPI) networks with diverse topology features. In this study, we investigate what kind of proteins is inclined to be essential from a new perspective. The investigation implies that protein essentiality is correlated with protein domains, which are functional, structural and evolutionary units of proteins. Proteins with a larger Number of Domain Types (NDT) tend to be essential. The analyses on 22 species show that essential proteins identified by NDT are much more than those identified by ten random identifications. The consideration of the structural feature makes us less dependent on network data and thus enables us to investigate protein essentiality of more species with incomplete and/or inconsistent network data.
authors: School of Information Science and Engineering, Central South University, Changsha 410083, China.
authors: Lu
authors: L
authors: Chen
authors: School of Information Science and Engineering, Central South University, Changsha 410083, China.
authors: Yingjiao
authors: Y
authors: Cheng
authors: School of Information Science and Engineering, Central South University, Changsha 410083, China.
authors: Min
authors: M
authors: Li
authors: School of Information Science and Engineering, Central South University, Changsha 410083, China.
authors: Jianxin
authors: J
authors: Wang
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D020539:Sequence Analysis, Protein / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins
keywords: PPI; bioinformatics; domain types; essential proteins; incomplete data; inconsistent data; protein–protein interaction networks