title: Optical coherence tomography in patients with Chiari I malformation.
abstract: OBJECTIVE
  To evaluate optic nerve head with spectral domain optical coherence tomography (OCT) in patients with Chiari I malformation (CMI) compared to healthy controls.
  
  
  METHODS
  Cross-sectional study. OCT of the optic nerve head of 22 patients with CMI and 22 healthy controls was quantitatively analyzed. The healthy controls were matched for age and sex with the study population. Mean retinal nerve fiber layer (RNFL) thickness was calculated for both eyes; the mean thickness value was also registered for each quadrant and for each subfield of the four quadrants.
  
  
  RESULTS
  CMI patients showed a reduction of the RNFL thickness in both eyes. This reduction was more statistically significant (P < 0.05) for the inferior quadrant in the right eye and in each quadrant than nasal one in the left eye.
  
  
  CONCLUSIONS
  A distress of the retinal nerve fibers could explain the observed reduction of the RNFL thickness in patients with CMI; in our series the reduction of the RNFL thickness seems lower when CMI is associated with syringomyelia.
authors: Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.
authors: Michele
authors: 0000-0003-3211-3344
authors: M
authors: Figus
authors: Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.
authors: Chiara
authors: 0000-0003-0222-5177
authors: C
authors: Posarelli
authors: Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.
authors: Francesco
authors: 0000-0001-7618-7308
authors: F
authors: Nasini
authors: Department of Neurosurgery 2, University of Pisa, 56124 Pisa, Italy.
authors: Paolo
authors: P
authors: Perrini
authors: Department of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, 56124 Pisa, Italy.
authors: Mario
authors: M
authors: Miccoli
authors: Department of Translational Research and Advanced Technologies in Medicine and Surgery, University of Pisa, 56124 Pisa, Italy.
authors: Angelo
authors: A
authors: Baggiani
authors: Miguel Servet University Hospital, Aragon Health Sciences Institute, Zaragoza, Spain.
authors: Antonio
authors: 0000-0002-2914-2593
authors: A
authors: Ferreras
authors: Department of Surgical, Medical, Molecular Pathology and Emergency, University of Pisa, 56124 Pisa, Italy.
authors: Marco
authors: M
authors: Nardi
mesh_terms: D000328:Adult; D001139:Arnold-Chiari Malformation / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000000981:diagnostic imaging* / Q000473:pathology; D009898:Optic Disk / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000000981:diagnostic imaging / Q000473:pathology; D041623:Tomography, Optical Coherence