title: Silk fibroin nanoparticle as a novel drug delivery system.
abstract: Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Nanocarrier-based drug delivery systems, in particular nanoparticles, have generated great excitement in the field of drug delivery since they provide new opportunities to overcome the limitations of conventional delivery methods with regards to the drugs. Silk fibroin (SF) is a naturally occurring protein polymer with several unique properties that make it a suitable material for incorporation into a variety of drug delivery vehicles capable of delivering a range of therapeutic agents. SF matrices have been shown to successfully deliver anticancer drugs, small molecules, and biomolecules. This review will provide an in-depth discussion of the development of SF nanoparticle-based drug delivery systems.
authors: Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors: Fatemeh
authors: F
authors: Mottaghitalab
authors: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran. Electronic address: mehdifarkhi83@gmail.com.
authors: Mehdi
authors: M
authors: Farokhi
authors: National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran.
authors: Mohammad Ali
authors: MA
authors: Shokrgozar
authors: Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 14174, Iran.
authors: Fatemeh
authors: F
authors: Atyabi
authors: Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan; Center of Excellence in Nanomedicine, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
authors: Hossein
authors: H
authors: Hosseinkhani
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D012831:Bombyx / Q000737:chemistry*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005349:Fibroins / Q000737:chemistry* / Q000648:ultrastructure; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011506:Proteins / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011506:Proteins; D005349:Fibroins
keywords: Drug delivery; Nanoparticles; Silk fibroin