title: Improved Outcomes for Women on the Heart Transplant Wait List in the Modern Era.
abstract: BACKGROUND
  Whether the routine use of continuous-flow left ventricular assist devices (LVAD) has affected gender differences in outcomes for patients listed for heart transplantation (HT) is unclear.
  
  
  RESULTS
  We identified 20,468 adults (25% women) listed as status 1A or 1B for HT from 2000 to 2014. Sex differences in removal from the wait list during the first 365 days due to death or deterioration was assessed with the use of Kaplan-Meier survival analysis. Patients were stratified according to listing before (era 1) or after (era 2) Food and Drug Administration approval of the Heartmate II LVAD on April 22, 2008. Freedom from death or deterioration on the wait list was higher for men than for women (70% vs 64%; P < .001). After adjusting for risk factors, women had a higher risk of removal from the wait list at 365 days during both era 1 (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.10-1.36; P < .001) and era 2 (HR 1.15, 95% CI 1.01-1.31; P = .029). Further adjustment for LVAD use eliminated the higher risk for women in era 2 (HR 1.14, 95% CI 0.99-1.29; P = .053) and not in era 1 (HR 1.22, 95% CI 1.10-1.36; P < .001).
  
  
  CONCLUSIONS
  The higher risk for death or deterioration in women waiting for HT has improved in the modern era.
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Division of Cardiology Department of Medicine, Atlanta VA Medical Center, Atlanta, Georgia. Electronic address: aamorr3@emory.edu.
authors: Alanna A
authors: AA
authors: Morris
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors: Robert T
authors: RT
authors: Cole
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors: S Raja
authors: SR
authors: Laskar
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors: Andreas
authors: A
authors: Kalogeropoulos
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Division of Cardiology Department of Medicine, Atlanta VA Medical Center, Atlanta, Georgia.
authors: J David
authors: JD
authors: Vega
authors: Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors: Andrew
authors: A
authors: Smith
authors: Division of Cardiology Department of Medicine, Stony Brook University, Stony Brook, New York.
authors: Javed
authors: J
authors: Butler
mesh_terms: D000328:Adult; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D016027:Heart Transplantation / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends; D006353:Heart-Assist Devices / Q000706:statistics & numerical data*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010043:Outcome and Process Assessment, Health Care; D011300:Preoperative Care / Q000295:instrumentation / Q000379:methods / Q000401:mortality / Q000639:trends; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D014850:Waiting Lists / Q000401:mortality*
keywords: Sex; heart transplant; ventricular assist device