title: Characteristics of Sleep-Disordered Breathing in Etiologic Subtypes of Minor-to-Moderate Acute Ischemic Stroke.
abstract: BACKGROUND
  Sleep-disordered breathing (SDB) is frequent in stroke patients. A strong association has been suggested between SDB and atrial fibrillation (AF). In this study, we evaluated the characteristics of SDB in etiologic subtypes of acute ischemic stroke. We also investigated the relationship between SDB and AF in acute ischemic stroke.
  
  
  METHODS
  We prospectively enrolled 72 patients with minor-to-moderate acute ischemic stroke. Clinical and laboratory characteristics of population were recorded on admission. SDB was assessed using standard polysomnography within 7 days after stroke onset.
  
  
  RESULTS
  Apnea-hypopnea index (AHI) in small-vessel strokes was significantly lower than that in large-artery atherosclerosis strokes (P = .031), cardioembolic strokes (P = .011), and strokes of other or unknown etiology (.008). Desaturation index (DI) in small-vessel strokes was significantly lower than that in cardioembolic strokes and in large-artery strokes (P = .008, P = .035). Arousal index (AI) in large-artery strokes was significantly higher than that in small-vessel strokes (P = .013), cardioembolic strokes (P = .007), and strokes of other or unknown etiology (.027). In a multivariate regression model were age (odds ratio [OR], 1.083; 95% confidence interval [CI], 1.022-1.148; P = .007) and DI (OR, 1.037; 95% CI, 1.004-1.071; P = .026) the only significant variables independently associated with AF.
  
  
  CONCLUSIONS
  We observed higher AHI, DI, and AI in large-artery strokes that may relate to more severe neurologic deficit in this subgroup. Age and DI were the only independent variables significantly associated with AF in acute ischemic stroke. Higher AHI and DI in cardioembolic strokes may thus mirror more frequent premorbid presence of SDB in patients with AF.
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Pavel
authors: P
authors: Šiarnik
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. Electronic address: branislavkollarmd@gmail.com.
authors: Branislav
authors: B
authors: Kollár
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Zuzana
authors: Z
authors: Čarnická
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Stanislav
authors: S
authors: Šutovský
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Katarína
authors: K
authors: Klobučníková
authors: 1(st) Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
authors: Peter
authors: P
authors: Turčáni
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000145:classification* / Q000150:complications* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011446:Prospective Studies; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000209:etiology*; D015898:Tomography Scanners, X-Ray Computed
keywords: Sleep-disordered breathing; atrial fibrillation; etiologic stroke subtypes; ischemic stroke; polysomnography