title: Protective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds.
abstract: Steroid hormones synthesized in and secreted from peripheral endocrine glands pass through the blood-brain barrier and play a role in the central nervous system. In addition, the brain possesses an inherent endocrine system and synthesizes steroid hormones known as neurosteroids. Increasing evidence shows that neuroactive steroids protect the central nervous system from various harmful stimuli. Reports show that the neuroprotective actions of steroid hormones attenuate oxidative stress. In this review, we summarize the antioxidative effects of neuroactive steroids, especially 17β-estradiol and progesterone, on neuronal injury in the central nervous system under various pathological conditions, and then describe our recent findings concerning the neuroprotective actions of 17β-estradiol and progesterone on oxidative neuronal injury induced by organometallic compounds, tributyltin, and methylmercury.
authors: Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima 739-8521, Japan.
authors: Yasuhiro
authors: Y
authors: Ishihara
authors: Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima 739-8521, Japan.
authors: Takuya
authors: T
authors: Takemoto
authors: Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima 739-8521, Japan.
authors: Atsuhiko
authors: 0000-0002-6280-2055
authors: A
authors: Ishida
authors: Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima 739-8521, Japan.
authors: Takeshi
authors: T
authors: Yamazaki
mesh_terms: D002490:Central Nervous System / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D006801:Humans; D009942:Organometallic Compounds / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D011374:Progesterone; D004958:Estradiol; D010088:Oxidoreductases