title: A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats.
abstract: An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.
authors: Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China.
authors: Xuntai
authors: X
authors: Ma
authors: Department of Histology and Embryology, Institute of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China ; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors: Yong
authors: Y
authors: Tang
authors: Department of Geriatrics, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors: Yang
authors: Y
authors: Lv
authors: Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors: Oumei
authors: O
authors: Cheng
authors: Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors: Yong
authors: Y
authors: Yan
keywords: cortical dysplasia; heterotopic nodules; medullary sheath; myelinated fibers; stereology; white matter