title: Erythrocyte: A systems model of the control of aggregation and deformability.
abstract: Human erythrocytes are highly specialized enucleate cells that are involved in providing efficient gas transport. Erythrocytes have been extensively studied both experimentally and by mathematical modeling in recent years. However, understanding of how aggregation and deformability are regulated is limited. These properties of the erythrocyte are essential for the physiological functioning of the cell. In this work, we propose a novel mathematical model of the molecular system that controls the aggregation and deformability of the erythrocyte. This model is based on the experimental results of previously published studies. Our model suggests fundamentally new mechanisms that regulate aggregation and deformability in a latch-like manner. The results of this work could be used as a general explanation of how the erythrocytes regulate their aggregation and deformability, and are essential in understanding erythrocyte disorders and aging.
authors: Institute of Physics, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation. Electronic address: antonina.bazanovas@yandex.ru.
authors: Antonina N
authors: AN
authors: Bazanovas
authors: Institute of Physics, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation. Electronic address: alevstiv@gmail.com.
authors: Aleksandr I
authors: AI
authors: Evstifeev
authors: Department of Biochemistry and Molecular Biology, University of Nevada, Reno, School of Medicine, Reno, NV, USA; Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation. Electronic address: sv.khaiboullina@gmail.com.
authors: Svetlana F
authors: SF
authors: Khaiboullina
authors: College of Engineering, Mathematics and Physical Sciences, University of Exeter, EX4 4QF Exeter, UK. Electronic address: ildar.sadreev@gmail.com.
authors: Ildar I
authors: II
authors: Sadreev
authors: Institute of Physics, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation; Kazan Institute of Biochemistry and Biophysics, 420111 Kazan, Russian Federation. Electronic address: askorink@yandex.ru.
authors: Andrey I
authors: AI
authors: Skorinkin
authors: Institute of Physics, Kazan Federal University, 420008 Kazan, Republic of Tatarstan, Russian Federation. Electronic address: nvkotov@gmail.com.
authors: Nikolay V
authors: NV
authors: Kotov
mesh_terms: D002449:Cell Aggregation; D004912:Erythrocytes / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction
keywords: Aggregation; Calcium; Calmodulin; Deformability; Erythrocyte