title: Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults.
abstract: OBJECTIVE
  To investigate in a population sample of Portuguese young adults the association of the FTO variant rs9939609 with obesity, BMI, and body-fat and interaction with physical activity (PA) on obesity-susceptibility.
  
  
  METHODS
  SNP rs9939609 A/T was genotyped in 550 subjects (231 males and 319 females; 18-36 years old; mean age 21 years old) by TaqMan assay. PA was assessed with a validated self-reported questionnaire of IPAQ.
  
  
  RESULTS
  We replicated the association of rs9939609-A risk allele with BMI (P = 0.04) and fat-mass (P = 0.031), and with overweight (including obesity) under a recessive model (P = 0.034). Stratified analyses showed (i) a significant association with overweight/obesity in inactive individuals (P = 0.02) but not in a group reporting participation in sports (P = 0.97). Spearman's correlation test suggested that the impact of a successive increase in PA was a decrease in the body-fat percentage (r = -0.16; P = 0.0002), which is accentuated for homozygous AA (r = -0.34; P = 0.002), and an increase in BMI (r = 0.14; P = 0.001), with a statistically significant correlation for homozygous TT (r = 0.22; P = 0.002).
  
  
  CONCLUSIONS
  This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes.
authors: Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.|Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
authors: Magdalena
authors: M
authors: Muc
authors: Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.|Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
authors: Cristina
authors: C
authors: Padez
authors: Research Centre for Anthropology and Health (CIAS), University of Coimbra, Coimbra, Portugal.|Department of Life Sciences, University of Coimbra, Coimbra, Portugal.
authors: Licínio
authors: L
authors: Manco
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics; D011110:Polymorphism, Genetic; D011174:Portugal / Q000453:epidemiology; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human