title: The complex evolution of antibiotic resistance in Mycobacterium tuberculosis.
abstract: Multidrug-resistant and extensively drug-resistant tuberculosis (TB) represent a major threat to the control of the disease worldwide. The mechanisms and pathways that result in the emergence and subsequent fixation of resistant strains of Mycobacterium tuberculosis are not fully understood and recent studies suggest that they are much more complex than initially thought. In this review, we highlight the exciting new areas of research within TB resistance that are beginning to fill these gaps in our understanding, whilst also raising new questions and providing future directions.
authors: Centre for Clinical Microbiology, University College London, London, NW3 2PF, UK. Electronic address: rebmjco@ucl.ac.uk.
authors: J D
authors: JD
authors: Fonseca
authors: TB Modelling Group, TB Centre, Centre for the Mathematical Modelling of Infectious Diseases, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
authors: G M
authors: GM
authors: Knight
authors: Centre for Clinical Microbiology, University College London, London, NW3 2PF, UK.
authors: T D
authors: TD
authors: McHugh
mesh_terms: D005075:Biological Evolution; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D054908:Extensively Drug-Resistant Tuberculosis / Q000382:microbiology; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*
keywords: Drug resistance; Molecular mechanisms of resistance; Tuberculosis