title: HIV-associated neurocognitive disorders: the relationship of HIV infection with physical and social comorbidities.
abstract: The prevalence of HIV (human immunodeficiency virus) associated neurocognitive disorders (HAND) will undoubtedly increase with the improved longevity of HIV-infected persons. HIV infection, itself, as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications. These comorbidities confound the diagnosis, assessment, and interventions for neurocognitive disorders. In this review, we discuss the role of several key comorbid factors that may contribute significantly to the development and progression of HIV-related neurocognitive impairment, as well as the current status of diagnostic strategies aimed at identifying HIV-infected individuals with impaired cognition and future research priorities and challenges.
authors: Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors: Ellen M
authors: EM
authors: Tedaldi
authors: Department of Physical Medicine and Rehabilitation, Temple University Hospital, Philadelphia, PA 19140, USA.
authors: Nancy L
authors: NL
authors: Minniti
authors: Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
authors: Tracy
authors: T
authors: Fischer
mesh_terms: D000375:Aging / Q000473:pathology; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015897:Comorbidity; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology