title: Insulinoma in a patient with chronic renal failure due to type 2 diabetes mellitus treated effectively with diazoxide.
abstract: A 63-year-old man was diagnosed with diabetes mellitus at 42 years of age. He subsequently exhibited poor blood glucose control for a prolonged period, and his renal failure worsened. He therefore underwent hemodialysis and abdominal magnetic resonance imaging, which revealed a mass in the pancreatic tail. The immunoreactive insulin and C-peptide immunoreactivity levels were significantly elevated, and the results of a fasting test led to a diagnosis of insulinoma. The patient received treatment with oral diazoxide and continuous glucose monitoring (CGM), which resulted in the resolution of the hypoglycemia. This is a rare case of renal failure in which the CGM findings showed improvements in the blood glucose level after diazoxide administration.
authors: Department of Endocrinology and Metabolism, Dokkyo Medical University, Japan.
authors: Masanori
authors: M
authors: Shimizu
authors: Kunihiro
authors: K
authors: Suzuki
authors: Kohei
authors: K
authors: Tsuchida
authors: Masaru
authors: M
authors: Kojima
authors: Hideyuki
authors: H
authors: Hiraishi
authors: Yoshimasa
authors: Y
authors: Aso
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D003981:Diazoxide / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications*; D006435:Renal Dialysis; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D014408:Biomarkers, Tumor; D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D014665:Vasodilator Agents; D003981:Diazoxide