title: Tandem gold-catalyzed dehydrative cyclization/diels-alder reactions: facile access to indolocarbazole alkaloids.
abstract: A gold-catalyzed synthesis of cyclic 2-oxodienes from readily prepared propargyl alcohols and the subsequent Diels-Alder reaction are reported. The dehydrative cyclization reactions proceeded smoothly, and the dienes formed in situ were demonstrated to undergo cycloaddition with a variety of dienophiles. This method offers a new strategy for the synthesis of indolocarbazole alkaloids, whereby the convergent synthetic design allows for differentiation between the indole nitrogens.
authors: Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, Florida 32611, United States.
authors: Nicholas V
authors: NV
authors: Borrero
authors: Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, Florida 32611, United States.
authors: Lindsey G
authors: LG
authors: DeRatt
authors: Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, Florida 32611, United States.
authors: Lais
authors: L
authors: Ferreira Barbosa
authors: Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, Florida 32611, United States.
authors: Khalil A
authors: KA
authors: Abboud
authors: Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville, Florida 32611, United States.
authors: Aaron
authors: A
authors: Aponick