title: Gold Nanorods Bioconjugates for Intracellular Delivery and Cancer Cell Apoptosis.
abstract: The aim of this study was to identify an improved delivery scheme for intracellular delivery and anticancer therapy. Novel gold nanorods (GNRs) bioconjugates were prepared by using GNRs as nonviral vectors conjugated with thiol-modified antisense oligodeoxynucleotides (ASODNs). We then investigated the possibility of using GNRs as carriers for nucleus delivery of ASODNs genes by using confocal microscopy and cell transmission electron microscope imaging. Our results demonstrate that the GNRs-ASODNs entered into the cell nucleus and increased cell apoptosis. Therefore, the GNRs could hold great promise for biological delivery applications and gene therapy.
authors: Med-X Research Institutes, Shanghai Jiaotong University, Shanghai, China.
authors: Shouhui
authors: S
authors: Chen
authors: Department of Pediatric Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
authors: Qifeng
authors: Q
authors: Li
authors: Med-X Research Institutes, Shanghai Jiaotong University, Shanghai, China.
authors: Yan
authors: Y
authors: Xu
authors: Department of Surgery, Shanghai Jiaotong University Affiliated Shanghai First People's Hospital, Shanghai, China.
authors: Hao
authors: H
authors: Li
authors: Med-X Research Institutes, Shanghai Jiaotong University, Shanghai, China dingxianting@gmail.com.
authors: Xianting
authors: X
authors: Ding
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D058726:Nanoconjugates / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058726:Nanoconjugates; D006046:Gold
keywords: ASODNs; bioconjugates; cell apoptosis; gold nanorods