title: Red cell distribution width and inappropriateness of left ventricular mass in patients with untreated essential hypertension.
abstract: BACKGROUND
  Left ventricular hypertrophy (LVH) was suggested to be an important risk factor for hypertensive vascular complications. Previous studies had also shown that red cell distribution width (RDW) was associated with morbidity and mortality of cardiovascular disease. However, few have yet investigated possible association between RDW and LVH. The aim of the present study was to evaluate the relationship between LVH and RDW levels in hypertensive patients.
  
  
  METHODS
  Physical examination, laboratory tests and echocardiography were conducted in 330 untreated newly diagnosed hypertensive patients attending the cardiology consultation unit at the Anzhen Hospital of Beijing. The multivariate logistic regression model was used to verify the independent association between RDW and LVH.
  
  
  RESULTS
  174 patients without LVH and 156 patients with LVH were rolled in the study. The patients with LVH had higher mean SBP, albumin to creatinine ratio, total cholesterol, RDW and fasting glucose compared with non-LVH group. The mean HDL-cholesterol level was significantly lower in patients with LVH than patients without LVH. The multiple logistic regression model suggested that patients with a higher RDW level were more likely to be LVH (OR=2.187, 95%CI: 1.447-3.307, P<0.001). Other predictive factors for LVH were mean SBP, serum creatinine, glucose level. The receiver operating characteristics (ROC) curves indicated area under the curve was 0.688(95%CI: 0.635-0.737, P<0.001) with a cut-off value of 12.9, the RDW predicted LVH status among hypertensive patients with a sensitivity of 72.4% and a specificity of 60.3%.
  
  
  CONCLUSIONS
  The higher RDW level was observed in the LVH group compared with the non-LVH group. RDW might be associated with LVH in hypertensive patients. These data highlight the role of RDW as a predictor of organ damage in essential hypertensive patients.
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Lizhang
authors: L
authors: Chen
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Zhanzhan
authors: Z
authors: Li
authors: Department of emergency, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China.
authors: Yanyan
authors: Y
authors: Li
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Jing
authors: J
authors: Xue
authors: Xiangya Medical School, Central South University, Changsha, Hunan Province, China.
authors: Peng
authors: P
authors: Chen
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Shipeng
authors: S
authors: Yan
authors: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.
authors: Caixiao
authors: C
authors: Jiang
authors: Hunan provincial tumor hospital, Changsha, Hunan Province, China.
authors: Yingyun
authors: Y
authors: Hu
authors: Department of Plastic Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.
authors: Xing
authors: X
authors: Qiao
mesh_terms: D004909:Erythrocyte Indices; D000075222:Essential Hypertension; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000473:pathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000150:complications / Q000473:pathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009929:Organ Size; D012372:ROC Curve