title: Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains.
abstract: While isolating fungal strains from soil samples, two strains, Talaromyces siamensis FKA-61 and Phomopsis sp. FKA-62, were found to produce a black pigment near the boundary with an adjoining colony on agar plates. Moreover, strain FKA-61 inhibited the growth of strain FKA-62. Co-culture of T. siamensis FKA-61 with Phomopsis sp. FKA-62 resulted in the production of an antifungal agent, BE-31405, which proved active against Phomopsis sp. FKA-62. We screened for fungal genera that have the ability to induce production of antifungal BE-31405. Surprisingly, production of BE-31405 was induced only by co-culturing T. siamensis FKA-61 with a variety of BE-31405-sensitive fungal strains but never with BE-31405-insensitive strains. This is the first report of the induced production of a specific antibiotic active against antibiotic-sensitive fungal strains by co-culturing with them.
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors: Kenichi
authors: K
authors: Nonaka
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors: Masato
authors: M
authors: Iwatsuki
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors: Syunsuke
authors: S
authors: Horiuchi
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors: Kazuro
authors: K
authors: Shiomi
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Ōmura
authors: Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
authors: Rokuro
authors: R
authors: Masuma
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification*; D001952:Bridged-Ring Compounds / Q000302:isolation & purification*; D018920:Coculture Techniques; D005658:Fungi / Q000378:metabolism*; D012988:Soil Microbiology; D032901:Talaromyces / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; C117815:BE 31405; D001952:Bridged-Ring Compounds