title: Pagetoid dyskeratosis in dermatopathology.
abstract: Pagetoid dyskeratosis (PD) is an incidental pathologic finding that appears in several skin conditions. In an attempt to better understand PD and its incidence in dermatopathology, the authors have analyzed all skin biopsies performed over the period of 1 year in our Department of Dermatology and examined their clinical and dermatopathological variables. The criteria used for a keratinocyte to be considered a PD cell were: (1) a size larger than normal, (2) the presence of pycnotic nucleus, (3) a clear halo surrounding the nucleus, and (4) a pale eosinophilic cytoplasm. A total of 3565 biopsies were analyzed, PD cells being found in 80 cases (2.24%). Melanocytic nevi were the commonest skin lesions in which PD was observed, followed by soft fibromas, angiofibromas, and acrochordons. Most lesions were located on the head, neck, and trunk. Most cases displayed fewer than 15 PD cells per field. PD cells were normally located in the mid epidermis (frequently in clusters). The biopsies usually revealed indirect signs of rubbing, although PD cells were also found in places where rubbing was unlikely. Here, the authors report the largest series of PD analyzed to date, expanding our understanding of this striking pathological observation.
authors: *Dermatopathologist, Service of Dermatology, Department of Pathology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; †Dermatologist, Service of Dermatology, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; ‡Pathologist, Department of Pathology, Hospital Universitario de Salamanca, Salamanca, Spain; §Dermatologist, Service of Dermatology, Hospital Clinic, Barcelona, Spain; and ¶Dermatologist, Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
authors: Angel
authors: A
authors: Santos-Briz
authors: Javier
authors: J
authors: Cañueto
authors: Sofía
authors: S
authors: del Carmen
authors: Jose M
authors: JM
authors: Mir-Bonafe
authors: Emilia
authors: E
authors: Fernandez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D048430:Cell Shape; D048429:Cell Size; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology*; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000145:classification / Q000473:pathology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012871:Skin Diseases / Q000145:classification / Q000473:pathology*; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*; D013030:Spain; D009626:Terminology as Topic; D055815:Young Adult