title: Malignancy does not dictate the hypercoagulable state following liver resection.
abstract: BACKGROUND
  A hypercoagulable state following intra-abdominal malignant resections has been reported. Whether this is because of the operation or the malignancy, a known cause of hypercoagulability, remains unclear. We determined if malignancy status affected the coagulation profile following liver resection by assessing perioperative thromboelastogram (TEG) values.
  
  
  METHODS
  Retrospective review of prospectively collected TEG values in patients who received a liver resection was conducted. Values among patients with benign or malignant disease were compared.
  
  
  RESULTS
  Fourteen and 63 patients were resected for benign and malignant disease, respectively. No significant differences in TEG values existed between the groups. Combining the groups, patients developed a relative hypercoagulable state postoperatively with decreased R-times (P < .05), although median values remained within the normal range.
  
  
  CONCLUSIONS
  Following liver resection, no differences in TEG values existed between patients with benign and malignant disease; the relative hypercoagulable state is more likely driven by postoperative coagulopathy rather than the malignancy status of the patient.
authors: Division of Trauma, Critical Care and Acute Care Surgery, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA. Electronic address: gordonni@ohsu.edu.
authors: Nicole
authors: N
authors: Gordon
authors: Billings Clinic, 801 North 29th Street, Billings, MT, USA.
authors: Gordon
authors: G
authors: Riha
authors: Division of Surgical Oncology, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA.
authors: Kevin
authors: K
authors: Billingsley
authors: Division of Trauma, Critical Care and Acute Care Surgery, Department of General Surgery, Oregon Health & Science University, Portland, OR, USA.
authors: Martin
authors: M
authors: Schreiber
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009922:Oregon / Q000453:epidemiology; D012189:Retrospective Studies; D013916:Thrombelastography; D019851:Thrombophilia / Q000097:blood / Q000453:epidemiology / Q000209:etiology*
keywords: Benign; Hypercoagulable; Liver; Malignancy; TEG; Thromboelastography