title: In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads.
abstract: In the present study, sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) blend hydrogel beads were prepared in ferric chloride solution. The developed hydrogel beads exhibited pH sensitive for deliver Metformin hydrochloride (MH). Preparation conditions of the beads (ferric chloride solution) were significantly affected the encapsulation efficiency, swelling and in vitro release profiles of the beads. Swelling studies were accomplished in gastric and intestine stimuli atmosphere at 37°C. The swelling studies reveal that the beads at pH 7.4 showed higher swelling properties compare to pH 1.2. Exterior morphology of beads was analyzed by scanning electron microscope. SEM indicates the surface of the beads is spherical with smooth surface and size of beads drastically reduced with increasing crosslinker concentration. The crosslinking reaction between NaAlg and NaCMC with ferric chloride was confirmed by FTIR analysis. XRD analysis indicates that MH drug molecularly dispersed in the polymer matrix. In vitro release studies of MH loaded beads showed higher release profiles at pH 7.4 compared to pH 1.2. The polymeric matrices followed slightly deviation with Fickian diffusion and fit for experimental co-relation (r(2)) values.
authors: Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea.
authors: Bala Yerri
authors: BY
authors: Swamy
authors: Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonju, Chonbuk 561-756, Republic of Korea. Electronic address: ysyun@jbnu.ac.kr.
authors: Yeoung-Sang
authors: YS
authors: Yun
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D007700:Kinetics; D008687:Metformin / Q000737:chemistry*; D008863:Microspheres
chemical_list: D000464:Alginates; D002712:Chlorides; D004337:Drug Carriers; D005290:Ferric Compounds; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D008687:Metformin; D007501:Iron; D002266:Carboxymethylcellulose Sodium; C024555:ferric chloride
keywords: Hydrogel beads; Metformin hydrochloride (MH); Sodium alginate (NaAlg); Sodium carboxymethyl cellulose (NaCMC); pH sensitive