title: Pearls and pitfalls in diagnosis and management of coats disease.
abstract: OBJECTIVE
  To review current literature on Coats disease and provide a structured framework for differentiating challenging clinical features in Coats disease patients.
  
  
  METHODS
  We critically reappraise historical and current literature and present clinical methods for developing a thorough differential diagnosis and management strategy for Coats disease.
  
  
  RESULTS
  Coats disease is a sporadic, usually unilateral condition typically occurring in young males. When untreated, this disorder can lead to total exudative retinal detachment and secondary glaucoma.
  
  
  CONCLUSIONS
  Anti-VEGF agents are currently a treatment option in combination with ablative therapy of telangiectatic vessels. Anti-VEGF agents appear particularly useful for patients with extensive areas of exudative retinal detachment, and are an effective treatment option for total retinal detachment.
authors: *Department of Ophthalmology, Torino Eye Hospital and Centre for Macular Research and Allied Diseases, San Mauro, Italy; †Department of Biomedical and Clinical Science "Luigi Sacco", Eye Clinic, Sacco Hospital, University of Milan, Milan, Italy; ‡Department of Ophthalmology, Torino Eye Hospital, Torino, Italy; §Ophthalmic Consultants of Long Island, Division of Retina and Vitreous, Rockville Centre, New York; and ¶Ophthalmic Consultants of Long Island, Division of Retina and Vitreous, Lynbrook, New York.
authors: Andrea
authors: A
authors: Grosso
authors: Marco
authors: M
authors: Pellegrini
authors: Matteo G
authors: MG
authors: Cereda
authors: Claudio
authors: C
authors: Panico
authors: Giovanni
authors: G
authors: Staurenghi
authors: Eric J
authors: EJ
authors: Sigler
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005901:Glaucoma / Q000209:etiology; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D012163:Retinal Detachment / Q000209:etiology; D058456:Retinal Telangiectasis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D012737:Sex Factors; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A