title: Glycated albumin as a diagnostic tool for diabetes in a general Japanese population.
abstract: OBJECTIVE
  Diabetes mellitus is a major cause of cardiovascular, kidney, neurologic, and eye diseases, and may be preventable in some cases by lifestyle modification. Screening tests for diabetes mellitus include fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c). Our objective was to evaluate the utility of plasma glycated albumin (GA) in the diagnosis of diabetes mellitus.
  
  
  METHODS
  A cross-sectional, community-based population study of 908 non-diabetic Japanese residents was conducted. Of these subjects, 176 with FPG value between 5.5 and 6.9mmol/l, and an HbA1c level of <6.5% received an oral glucose tolerance test (OGTT).
  
  
  RESULTS
  The OGTT results were used for the diagnosis of diabetes mellitus using World Health Organization criteria. Receiver operating characteristic (ROC) analyses demonstrated that optimal threshold values for the diagnosis of diabetes in this population were 15.2% for GA and 5.9% for HbA1c, respectively. Using these cutoff levels, the sensitivity of GA at 62.1% for detecting diabetes was the same as that of HbA1c. However the specificity for GA for detecting diabetes was 61.9%, while for HbA1c it was higher at 66.7%.
  
  
  CONCLUSIONS
  Our results indicate that the measurement of glycated albumin may serve as a useful screening test for diabetes in a general Japanese population.
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan; Cardiovascular Nutrition Laboratory, Jean Mayor USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
authors: Hiroaki
authors: H
authors: Ikezaki
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan. Electronic address: furusyo@gim.med.kyushu-u.ac.jp.
authors: Norihiro
authors: N
authors: Furusyo
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Takeshi
authors: T
authors: Ihara
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Takeo
authors: T
authors: Hayashi
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Kazuya
authors: K
authors: Ura
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Satoshi
authors: S
authors: Hiramine
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Fujiko
authors: F
authors: Mitsumoto
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Koji
authors: K
authors: Takayama
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan.
authors: Masayuki
authors: M
authors: Murata
authors: Diagnostic Department, Asahi-Kasei Pharma, Tokyo 1018101, Japan.
authors: Takuji
authors: T
authors: Kohzuma
authors: Department of Insured Medical Care Management, Tokyo Medical and Dental University Hospital, Tokyo 1138510, Japan.
authors: Masumi
authors: M
authors: Ai
authors: Cardiovascular Nutrition Laboratory, Jean Mayor USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
authors: Ernst J
authors: EJ
authors: Schaefer
authors: Department of General Internal Medicine, Kyushu University Hospital, Fukuoka 8128582, Japan; Kyushu General Internal Medicine Center, Hara-Doi Hospital, Fukuoka 8138588, Japan.
authors: Jun
authors: J
authors: Hayashi
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D017127:Glycation End Products, Advanced; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*; D055815:Young Adult; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Diabetes; Glycated albumin; Oral glucose tolerance test