title: [Meningococcal vaccines. Global epidemiological situation and strategies for prevention by vaccination].
abstract: N. meningitidis is a major cause of meningitis and septicemia and a major public health problem in many countries. The disease, that can be fulminant, has a high mortality and may cause serious sequelae, even in cases of apparently optimal medical treatment. Chemoprophylaxis may prevent secondary cases among those in close contact with the ill, but, since secondary cases represent only 1%-2% of all meningococcal disease, chemoprophylaxis has a small impact when fighting most of endemic and epidemic forms. Given that al least 5% -15% of children and young adults are carriers, the fight against meningococcal disease based on chemotherapeutic elimination of nasopharyngeal colonization is virtually impossible. Therefore, immunization is the only rational way to combat this disease.
authors: Pediatría Clínica, Infectológica y Traslacional. Departamento de Pediatría, Hospital Clínico Universitario de Santiago, Unidad de Investigación en Vacunas, GENVIP, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, La Coruña, España. Electronic address: irina667@hotmail.com.
authors: Irene
authors: I
authors: Rivero Calle
authors: Pediatría Clínica, Infectológica y Traslacional. Departamento de Pediatría, Hospital Clínico Universitario de Santiago, Unidad de Investigación en Vacunas, GENVIP, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, La Coruña, España.
authors: Carmen
authors: C
authors: Rodriguez-Tenreiro Sánchez
authors: Pediatría Clínica, Infectológica y Traslacional. Departamento de Pediatría, Hospital Clínico Universitario de Santiago, Unidad de Investigación en Vacunas, GENVIP, Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, La Coruña, España.
authors: Federico
authors: F
authors: Martinón-Torres
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D019072:Antibiotic Prophylaxis; D002353:Carrier State / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control; D004197:Disease Reservoirs; D005060:Europe / Q000453:epidemiology; D014943:Global Health; D006801:Humans; D015994:Incidence; D007223:Infant; D008589:Meningococcal Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D022401:Meningococcal Vaccines; D008875:Middle Aged; D009305:Nasopharynx / Q000382:microbiology; D009345:Neisseria meningitidis / Q000145:classification / Q000302:isolation & purification; D012703:Serotyping; D014611:Vaccination / Q000379:methods; D055815:Young Adult
chemical_list: D022401:Meningococcal Vaccines
keywords: Antimeningococcal vaccines; Enfermedad meningocócica; Meningococcal disease; Neisseria meningitidis; Vacunas antimeningocócicas