title: Fatty acid metabolism meets organelle dynamics.
abstract: Upon nutrient deprivation, cells metabolize fatty acids (FAs) in mitochondria to supply energy, but how FAs, stored as triacylglycerols in lipid droplets, reach mitochondria has been mysterious. Rambold et al. (2015) now show that FA mobilization depends on triacylglycerol lipolysis, whereas autophagy feeds the lipid droplet pool for continued fueling of mitochondria.
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.
authors: Laurence
authors: L
authors: Walch
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France.
authors: Alenka
authors: A
authors: Čopič
authors: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75013 Paris, France. Electronic address: jackson@ijm.univ-paris-diderot.fr.
authors: Catherine L
authors: CL
authors: Jackson
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D008066:Lipolysis / Q000502:physiology*; D063154:Mitochondrial Dynamics / Q000502:physiology*; D013217:Starvation / Q000378:metabolism*
chemical_list: D005227:Fatty Acids