title: Effects of increased surface coverage of polyvinylpyrrolidone over a polysulfone hemofilter membrane on permeability and cell adhesion during continuous hemofiltration.
abstract: The purpose of the present study was to evaluate the adhesiveness of blood cells and the solute removal performance change of modified polysulfone membranes which have increased polyvinylpyrrolidone (PVP) coverage over their surface. Continuous hemofiltration (CHF) experiments for 24 h were carried out using an ex vivo hemofilter evaluation system to compare a modified polysulfone hemofilter (SHG) with the conventional polysulfone hemofilter (SH). The 25 and 50 % cutoff values of the sieving coefficient of dextran after CHF and the protein concentration in the filtrate was higher in SHG, indicating that less fouling occurred in the SHG membrane. Adhesion of blood cells after 24 h of CHF was significantly higher in the case of SH than in the case of SHG. Blood cell adhesion and membrane fouling were reduced with the use of a polysulfone membrane modified with increased PVP coverage over the surface.
authors.affiliation: Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan, kokubo@kitasato-u.ac.jp.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kokubo
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kurihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsukao
authors.forename: Naoko
authors.initials: N
authors.lastname: Maruyama
authors.forename: Kozue
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shinbo
authors.forename: Minoru
authors.initials: M
authors.lastname: Hirose
authors.forename: Hirosuke
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001773:Blood Cells / Q000502:physiology*; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D006440:Hemofiltration / Q000295:instrumentation*; D008567:Membranes, Artificial; D010539:Permeability; D011108:Polymers; D011205:Povidone; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D013552:Swine
chemical_list: D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D011205:Povidone
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