title: Copper-catalysed cross-coupling: an untapped potential.
abstract: Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon-carbon (C-C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl-heteroaryl and heteroaryl-heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C-C bonds.
authors.affiliation: Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131, USA. rgiri@unm.edu.
authors.forename: Surendra
authors.initials: S
authors.lastname: Thapa
authors.forename: Bijay
authors.initials: B
authors.lastname: Shrestha
authors.forename: Santosh K
authors.initials: SK
authors.lastname: Gurung
authors.forename: Ramesh
authors.initials: R
authors.lastname: Giri