title: Ganoderma pfeifferi--A European relative of Ganoderma lucidum.
abstract: In contrast to well-studied and broadly used Ganoderma species, such as Ganoderma lucidum and Ganoderma applanatum, knowledge regarding Ganoderma pfeifferi is very limited. Herein is an overview of the phytochemistry, biological activities and possible applications of this mushroom species. In addition to triterpenoids and polysaccharides, G. pfeifferi contains unique sesquiterpenoids and other small molecular weight compounds. Some of these compounds exhibit remarkable antimicrobial activities in vitro and in vivo against multi-resistant bacteria, such as MRSA. Antiviral properties, UV-protection abilities and other activities are also known. Potential issues arising from the conversion of research results into practical applications are discussed.
authors.affiliation: University Greifswald, Institute for Pharmacy, D-17487 Greifswald, Germany. Electronic address: lindequi@uni-greifswald.de.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Lindequist
authors.affiliation: University Greifswald, Institute for Pharmacy, D-17487 Greifswald, Germany. Electronic address: wjuelich@uni-greifswald.de.
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Jülich
authors.affiliation: Biometec GmbH, Walther-Rathenau-Str. 49a, D-17489 Greifswald, Germany. Electronic address: witt@biometec.de.
authors.forename: Sabine
authors.initials: S
authors.lastname: Witt
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032902:Ganoderma / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015603:Keratinocytes / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D006873:Hydroquinones; D014315:Triterpenes; C408007:ganomycin A; C408008:ganomycin B
keywords: Antibacterial; Antiviral; Farnesylhydroquinones; Ganoderma pfeifferi; Ganodermataceae; Keratinocytes; Triterpenoids