title: [The effect of topology of quorum sensing-related genes in Pectobacterium atrosepticumon their expression].
abstract: In prokaryotic genomes, the neighboring genes are often located on the complementary DNA strands and adjoin each other by their 5'- or 3'-ends or even overlap by their open reading frames. It was suggested that such gene topology hasfunctional purpose providing the regulation of their expression. For those genes that overlap by their coding 3'-termini this assumption has not been confirmed experimentally. In a broad group of bacteria that belong to proteobacteria such a convergent gene arrangement is typical for functionally connected quorum sensing-related genes "P" and "R" that encode synthases of N-acyl homoserine lactones and their sensors, respectively. In the present study on the example of overlapping quorum sensing-related genes of plant pathogenic bacterium Pectobacterium atrosepticum SCRI1043--expI and expR it was shown that the topology of these genes determines the regula- tion of their expression.
authors.forename: N E
authors.initials: NE
authors.lastname: Gogoleva
authors.forename: L V
authors.initials: LV
authors.lastname: Shlykova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Gorshkov
authors.forename: A G
authors.initials: AG
authors.lastname: Daminova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gogolev
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism; D001483:Base Sequence; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D044043:Pectobacterium / Q000235:genetics / Q000502:physiology*; D053038:Quorum Sensing / Q000235:genetics*
chemical_list: D054742:Acyl-Butyrolactones