title: Estimating the number of sudden cardiac deaths attributable to the use of domperidone in France.
abstract: OBJECTIVE
  The aim of this study was to estimate of the number of sudden cardiac deaths attributable to the use of domperidone in France in 2012 METHODS: Computation of the attributable fraction, function of the increase in risk of sudden cardiac death induced by domperidone and of the exposure prevalence. Multiplying the attributable fraction by the risk of sudden cardiac death in the French population gives an estimation of the number of sudden cardiac deaths attributable to domperidone.
  
  
  RESULTS
  The use of domperidone in France is the cause of 231 deaths per year in the population aged 18 years or over.
  
  
  CONCLUSIONS
  This risk should be taken into consideration by clinicians when prescribing a drug which provides a minor benefit.
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Hill
authors.forename: Philippe
authors.initials: P
authors.lastname: Nicot
authors.forename: Christine
authors.initials: C
authors.lastname: Piette
authors.forename: Karelle
authors.initials: K
authors.lastname: Le Gleut
authors.forename: Gérard
authors.initials: G
authors.lastname: Durand
authors.forename: Bruno
authors.initials: B
authors.lastname: Toussaint
mesh_terms: D000932:Antiemetics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000209:etiology; D004294:Domperidone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D017723:Drug Utilization Review; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012306:Risk
chemical_list: D000932:Antiemetics; D004294:Domperidone
keywords: adverse effect; domperidone; pharmacoepidemiology; sudden cardiac death; surveillance