title: Convenient recycling and reuse of bombarded [¹⁸O]H₂O for the production and the application of [¹⁸F]F⁻.
abstract: The limited availability and the increasing demands of [(18)O]H2O force the reuse of bombarded [(18)O]H2O for the production of [(18)F]F(-) at least for the purposes of research. Therefore, inorganic and organic contaminants have to be removed from the [(18)O]H2O after bombardment. We present a simple, effective, easy-handling and reliable method of [(18)O]H2O purification including oxidation and distillation. The obtained recycled [(18)O]H2O had comparable quality to commercially distributed [(18)O]water. This was confirmed by a detailed comparison of produced radionuclides and their activities and the application of [(18)F]F(-) for the automated synthesis of [(18)F]fluspidine.
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany. Electronic address: s.roetering@hzdr.de.
authors.forename: Sven
authors.initials: S
authors.lastname: Rötering
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Franke
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Zessin
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Brust
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Füchtner
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Fischer
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Departments of Neuroradiopharmaceuticals and Production of Radiopharmaceuticals, POB 51 01 19, D-01314 Dresden, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Steinbach
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis / Q000302:isolation & purification; D057168:Distillation / Q000295:instrumentation / Q000379:methods; D004340:Drug Contamination; D017743:Equipment Reuse; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D010084:Oxidation-Reduction; D010103:Oxygen Isotopes / Q000737:chemistry*; D010880:Piperidines / Q000138:chemical synthesis / Q000302:isolation & purification; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification; D013051:Spectrometry, Gamma; D014867:Water / Q000737:chemistry*
chemical_list: C558383:1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine); D001572:Benzofurans; D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D010880:Piperidines; D019275:Radiopharmaceuticals; D014867:Water
keywords: Analysis methods; Production of [(18)F]fluoride; Purification of used [(18)O]water; Radiosynthesis; Recycling and reuse