title: Thromboembolic events following brachytherapy: case reports.
abstract: Pulsed-dose-rate (PDR) brachytherapy is a recent brachytherapy modality combining the radiobiological advantages of low-dose-rate (LDR) brachytherapy with increased possibilities of dose optimization and radiation safety. However, treatment duration remains protracted, as the prescribed dose is typically delivered through pulses that do not exceed 0.5 Gy/h for critical organs. It is frequently used for the treatment of gynaecological malignancies. Although, the relationship between thrombosis and cancer is well known, specific data on thromboembolic events during brachytherapy are scarce. We report two cases of major thromboembolic events during brachytherapy treatment for gynaecological malignancies. We discuss the possible causal relationship between brachytherapy procedures and the occurrence of thromboembolic events, drawing a preventive practical attitude.
authors.affiliation: Département de Radiothérapie, Institut de Cancérologie de la Loire - Lucien Neuwirth, Saint-Priest en Jarez.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Département of Radiation Oncology, Centre Antoine Lacassagne, Nice.
authors.forename: Alexander Tuan
authors.initials: AT
authors.lastname: Falk
authors.affiliation: Radiation Oncology, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.affiliation: Université Jean-Monnet, Groupe de Recherche surla Thrombose, St-Etienne ; Centre Hospitalier Universitaire, Service de Médecine Vasculaire et Thérapeutique, St-Etienne, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Bertoletti
authors.affiliation: Département de Radiothérapie, Institut de Cancérologie de la Loire - Lucien Neuwirth, Saint-Priest en Jarez.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
keywords: brachytherapy; endometrial cancer; pulmonary embolism; thromboembolic events
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