title: Standard bowel cleansing is highly ineffective in cirrhotic patients undergoing screening colonoscopy.
abstract: BACKGROUND
  Few data are available on tolerability and quality of standard bowel cleansing for colonoscopy in patients with chronic disease.
  
  
  OBJECTIVE
  We seek to evaluate the tolerability and results of lavage solution for colonoscopy in cirrhotic patients in comparison with controls.
  
  
  METHODS
  Fifty-three cirrhotic and fifty-two normal subjects undergoing colonoscopy were prospectively enrolled in the study. Data regarding tolerability of lavage solution were harvested at the pre-procedure visit. Data on level of bowel cleansing and other endoscopic variables were recorded after the procedure.
  
  
  RESULTS
  Rate of failure to complete the prescribed bowel preparation and incidence of side effects during its administration were similar between cirrhotic and normal subjects. Despite this, cirrhotic patients exhibited an insufficient level of bowel preparation with approximately half exhibiting bad colon cleansing level (49% versus 5% control, p<0.001).
  
  
  CONCLUSIONS
  Alternative bowel cleansing protocols are needed for cirrhotic subjects to better match their colonoscopic screening needs.
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy; Interdepartmental Endoscopic Service, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Salso
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy; Interdepartmental Endoscopic Service, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: De Leonardis
authors.affiliation: INMI L. Spallanzani Hospital, Rome, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Lionetti
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lenci
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Angelico
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Telese
authors.affiliation: Hepatology Unit, Policlinico Tor Vergata, Rome, Italy; Interdepartmental Endoscopic Service, Policlinico Tor Vergata, Rome, Italy. Electronic address: baiocchi@uniroma2.it.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Baiocchi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects; D002908:Chronic Disease; D003110:Colonic Neoplasms / Q000150:complications / Q000175:diagnosis*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols
keywords: Bowel cleansing; Colonoscopy; Liver cirrhosis