title: Regulation of N-myristoyltransferase by the calpain and caspase systems.
abstract: N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems.
authors.forename: Rajendra K
authors.initials: RK
authors.lastname: Sharma
authors.forename: Sujeet
authors.initials: S
authors.lastname: Kumar
authors.forename: Sreejit
authors.initials: S
authors.lastname: Parameswaran
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dimmock
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D002154:Calpain / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase; D002154:Calpain; D020169:Caspases