title: Dopaminergic modulation of synaptic plasticity in rat prefrontal neurons.
abstract: The prefrontal cortex (PFC) is thought to store the traces for a type of long-term memory - the abstract memory that determines the temporal structure of behavior often termed a "rule" or "strategy". Long-term synaptic plasticity might serve as an underlying cellular mechanism for this type of memory. We therefore studied the induction of synaptic plasticity in rat PFC neurons, maintained in vitro, with special emphasis on the functionally important neuromodulator dopamine. First, the induction of long-term potentiation (LTP) was facilitated in the presence of tonic/background dopamine in the bath, and the dose-dependency of this background dopamine followed an "inverted-U" function, where too high or too low dopamine levels could not facilitate LTP. Second, the induction of long-term depression (LTD) by low-frequency stimuli appeared to be independent of background dopamine, but required endogenous, phasically-released dopamine during the stimuli. Blockade of dopamine receptors during the stimuli and exaggeration of the effect of this endogenously-released dopamine by inhibition of dopamine transporter activity both blocked LTD. Thus, LTD induction also followed an inverted-U function in its dopamine-dependency. We conclude that PFC synaptic plasticity is powerfully modulated by dopamine through inverted-U-shaped dose-dependency.
authors.affiliation: Center for Medical Education, Faculty of Health Sciences, Ryotokuji University, Chiba, Japan, otani@ryotokuji-u.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Otani
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Kevin
authors.initials: K
authors.lastname: Blot
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D059290:Dopaminergic Neurons / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D017397:Prefrontal Cortex / Q000166:cytology*
chemical_list: D004298:Dopamine
references.citation: J Biol Chem. 2004 Aug 20;279(34):35671-8
references.pmid: 15159403
references.citation: Neuron. 2008 Apr 10;58(1):104-17
references.pmid: 18400167
references.citation: Neuropharmacology. 2007 Oct;53(5):583-7
references.pmid: 17709119
references.citation: Annu Rev Neurosci. 2007;30:259-88
references.pmid: 17600522
references.citation: Behav Brain Res. 2006 Nov 25;175(1):189-94
references.pmid: 16978714
references.citation: Prog Neurobiol. 2013 Apr;103:131-55
references.pmid: 22521602
references.citation: Biol Psychiatry. 2010 Feb 1;67(3):199-207
references.pmid: 19833323
references.citation: Cereb Cortex. 2009 Nov;19(11):2708-18
references.pmid: 19282455
references.citation: J Neurosci. 1999 Aug 15;19(16):7152-61
references.pmid: 10436068
references.citation: J Neurosci. 2005 Aug 10;25(32):7393-400
references.pmid: 16093390
references.citation: Neuroscience. 1999;94(4):1019-27
references.pmid: 10625044
references.citation: J Neurosci. 2004 Mar 10;24(10):2475-80
references.pmid: 15014123
references.citation: Eur J Neurosci. 2005 Jun;21(12):3310-20
references.pmid: 16026469
references.citation: Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):301-6
references.pmid: 11134516
references.citation: Neuroscience. 2003;119(2):497-505
references.pmid: 12770563
references.citation: Eur J Neurosci. 2004 Apr;19(7):1826-36
references.pmid: 15078556
references.citation: J Neurophysiol. 2007 Mar;97(3):2448-64
references.pmid: 17229830
references.citation: Neuroscience. 1987 Sep;22(3):849-62
references.pmid: 3683852
references.citation: Cereb Cortex. 2014 Apr;24(4):945-55
references.pmid: 23236206
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5632-7
references.pmid: 17369358
references.citation: J Neurosci. 1999 Nov 15;19(22):9788-802
references.pmid: 10559388
references.citation: Science. 2014 Sep 26;345(6204):1616-20
references.pmid: 25258080
references.citation: Schizophr Bull. 2010 Sep;36(5):919-34
references.pmid: 20566491
references.citation: J Neurosci. 1994 Oct;14(10):6084-93
references.pmid: 7931564
references.citation: J Biol Chem. 1995 Nov 17;270(46):27489-94
references.pmid: 7499206
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3236-41
references.pmid: 14981263
references.citation: Biol Psychiatry. 2014 Mar 1;75(5):361-70
references.pmid: 24011822
references.citation: Prog Brain Res. 2000;126:133-63
references.pmid: 11105645
references.citation: J Neurosci. 2006 May 3;26(18):4803-10
references.pmid: 16672653
references.citation: Neuroscience. 1998 Aug;85(3):669-76
references.pmid: 9639264
references.citation: J Neurochem. 2000 Oct;75(4):1775-8
references.pmid: 10987862
references.citation: J Neurophysiol. 1999 Oct;82(4):1927-33
references.pmid: 10515982
references.citation: Neurosci Lett. 1999 Sep 17;272(3):179-82
references.pmid: 10505610
references.citation: Prog Neurobiol. 2004 Sep;74(1):1-58
references.pmid: 15381316
references.citation: J Neurosci. 2004 Feb 11;24(6):1265-71
references.pmid: 14960596