title: Neonatal acute megakaryoblastic leukemia mimicking congenital neuroblastoma.
abstract: We describe a neonate with abdominal distension, massive hepatomegaly, and high serum neuron-specific enolase level suggestive of congenital neuroblastoma. The patient died of pulmonary hemorrhage after therapy. Autopsy revealed that the tumor cells in the liver indicated acute megakaryocytic leukemia with the RBM15-MKL1 fusion gene.
authors.affiliation: Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital Toyama, Japan.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Kawasaki
authors.affiliation: Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital Toyama, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Makimoto
authors.affiliation: Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Nomura
authors.affiliation: Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hoshino
authors.affiliation: Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Hamashima
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, University of Tokyo Tokyo, Japan.
authors.forename: Mitsuteru
authors.initials: M
authors.lastname: Hiwatari
authors.affiliation: Department of Pathology, National Center for Child Health and Development Tokyo, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, University of Tokyo Tokyo, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Takita
authors.affiliation: Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital Toyama, Japan.
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan ; Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Tokyo, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kanegane
keywords: Acute megakaryoblastic leukemia; RBM15-MKL1; neuroblastoma; neuron-specific enolase
references.citation: Leukemia. 2000 Jan;14(1):216-8
references.pmid: 10637500
references.citation: Pediatr Blood Cancer. 2011 May;56(5):846-9
references.pmid: 21370421
references.citation: J Pediatr Hematol Oncol. 2003 May;25(5):396-402
references.pmid: 12759627
references.citation: Arch Pathol Lab Med. 2003 Oct;127(10):1362-5
references.pmid: 14521454
references.citation: Nihon Rinsho. 2005 Aug;63 Suppl 8:717-9
references.pmid: 16149621
references.citation: Blood. 2009 Jul 30;114(5):937-51
references.pmid: 19357394
references.citation: Clin Chim Acta. 1980 Feb 28;101(2-3):257-64
references.pmid: 7357747
references.citation: Lab Invest. 1986 May;54(5):554-60
references.pmid: 3009968
references.citation: Am J Clin Pathol. 1992 Aug;98(2):214-21
references.pmid: 1510033
references.citation: Intern Med. 2000 Oct;39(10):843-6
references.pmid: 11030212
references.citation: Blood. 1990 Apr 1;75(7):1540-8
references.pmid: 2317561
references.citation: Br J Haematol. 2012 Nov;159(3):277-87
references.pmid: 22966823
references.citation: Pathobiology. 2007;74(2):97-114
references.pmid: 17587881
references.citation: J Pediatr Hematol Oncol. 2003 May;25(5):348-61
references.pmid: 12759620
references.citation: Br J Cancer. 1987 Jul;56(1):65-7
references.pmid: 3476145