title: Control of bacterial exoelectrogenesis by c-AMP-GMP.
abstract: Major changes in bacterial physiology including biofilm and spore formation involve signaling by the cyclic dinucleotides c-di-GMP and c-di-AMP. Recently, another second messenger dinucleotide, c-AMP-GMP, was found to control chemotaxis and colonization by Vibrio cholerae. We have identified a superregulon of genes controlled by c-AMP-GMP in numerous Deltaproteobacteria, including Geobacter species that use extracellular insoluble metal oxides as terminal electron acceptors. This exoelectrogenic process has been studied for its possible utility in energy production and bioremediation. Many genes involved in adhesion, pilin formation, and others that are important for exoelectrogenesis are controlled by members of a variant riboswitch class that selectively bind c-AMP-GMP. These RNAs constitute, to our knowledge, the first known specific receptors for c-AMP-GMP and reveal that this molecule is used by many bacteria to control specialized physiological processes.
authors.affiliation: Department of Chemistry.
authors.forename: James W
authors.initials: JW
authors.lastname: Nelson
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520.
authors.forename: Narasimhan
authors.initials: N
authors.lastname: Sudarsan
authors.affiliation: Department of Molecular Biophysics and Biochemistry.
authors.forename: Grace E
authors.initials: GE
authors.lastname: Phillips
authors.affiliation: Department of Molecular, Cellular and Developmental Biology.
authors.forename: Shira
authors.initials: S
authors.lastname: Stav
authors.affiliation: Department of Molecular, Cellular and Developmental Biology.
authors.forename: Christina E
authors.initials: CE
authors.lastname: Lünse
authors.affiliation: Department of Molecular, Cellular and Developmental Biology.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: McCown
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520 Department of Molecular Biophysics and Biochemistry, ronald.breaker@yale.edu.
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Breaker
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology; D055724:Electrophysiological Phenomena; D036781:Fimbriae Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D045302:Geobacter / Q000235:genetics / Q000378:metabolism*; D009712:Nucleotides, Cyclic / Q000235:genetics / Q000378:metabolism*; D010087:Oxides / Q000378:metabolism; D014734:Vibrio cholerae
chemical_list: D009712:Nucleotides, Cyclic; D010087:Oxides; C584311:cyclic guanosine monophosphate-adenosine monophosphate; D036781:Fimbriae Proteins
keywords: GEMM; Geobacter; c-di-GMP; riboswitch; second messenger
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