title: The interplay of the gut microbiome, bile acids, and volatile organic compounds.
abstract: Background. There has been an increasing interest in the use of volatile organic compounds (VOCs) as potential surrogate markers of gut dysbiosis in gastrointestinal disease. Gut dysbiosis occurs when pathological imbalances in gut bacterial colonies precipitate disease and has been linked to the dysmetabolism of bile acids (BA) in the gut. BA metabolites as a result of microbial transformations act as signaling molecules and have demonstrated regulation of intestinal homeostasis through the TGR5 and FXR receptors by inhibiting inflammation, preventing pathogen invasion, and maintaining cell integrity. The presence of VOC footprints is the resultant effect to gut microbiome substrate fermentation. Aim. To review the role of the gut microbiome and bile acid signaling in intestinal homeostasis and the resultant use of VOCs as potential noninvasive surrogate biomarkers in gut dysbiosis. Methods. A systematic search on PubMed and Medline databases was performed to identify articles relevant to gut dysbiosis, BA metabolism, and VOCs. Conclusions. The host and presence of the gut microbiome appear to regulate the BA pool size. A dysbiotic gut microbiome results in disrupted intestinal homeostasis, which may be reflected by VOCs, differentiating those who are healthy and those with disease.
authors.affiliation: Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Nidhi M
authors.initials: NM
authors.lastname: Sagar
authors.affiliation: Clinical Sciences Research Institute, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Cree
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Covington
authors.affiliation: Clinical Sciences Research Institute, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Ramesh P
authors.identifier: 0000-0002-2231-3062
authors.initials: RP
authors.lastname: Arasaradnam
references.citation: FEMS Microbiol Rev. 2005 Sep;29(4):625-51
references.pmid: 16102595
references.citation: J Lipid Res. 1979 Mar;20(3):325-33
references.pmid: 36438
references.citation: Biochem Biophys Res Commun. 2008 Jul 18;372(1):78-84
references.pmid: 18468513
references.citation: World J Gastroenterol. 2010 Sep 28;16(36):4532-40
references.pmid: 20857523
references.citation: Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7503-8
references.pmid: 20363958
references.citation: Inflamm Bowel Dis. 2013 Apr;19(5):999-1003
references.pmid: 23478806
references.citation: J Dig Dis. 2009 May;10(2):85-90
references.pmid: 19426389
references.citation: Pathogens. 2013 Dec 30;3(1):14-24
references.pmid: 25437605
references.citation: Neurogastroenterol Motil. 2012 Jun;24(6):513-20, e246-7
references.pmid: 22356587
references.citation: Lancet. 1998 Oct 10;352(9135):1187-9
references.pmid: 9777836
references.citation: Microbiologica. 1982 Jul;5(3):185-94
references.pmid: 7121297
references.citation: Clin Gastroenterol Hepatol. 2010 Feb;8(2):159-65
references.pmid: 19879973
references.citation: Aliment Pharmacol Ther. 2014 Apr;39(8):780-9
references.pmid: 24612215
references.citation: Aliment Pharmacol Ther. 2003 Apr 1;17(7):895-904
references.pmid: 12656692
references.citation: J Lipid Res. 2006 Feb;47(2):241-59
references.pmid: 16299351
references.citation: Gastroenterology. 2011 May;140(6):1768-75
references.pmid: 21530743
references.citation: Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4586-91
references.pmid: 20571116
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13580-5
references.pmid: 18757757
references.citation: Mol Cell. 2000 Sep;6(3):517-26
references.pmid: 11030332
references.citation: FEMS Immunol Med Microbiol. 2005 Feb 1;43(2):213-22
references.pmid: 15747442
references.citation: Gastroenterology. 2007 Mar;132(3):913-20
references.pmid: 17383420
references.citation: Nature. 2012 Jul 5;487(7405):104-8
references.pmid: 22722865
references.citation: World J Gastroenterol. 2004 Jun 15;10(12):1802-5
references.pmid: 15188510
references.citation: Gut. 1999 Mar;44(3):400-6
references.pmid: 10026328
references.citation: Neurogastroenterol Motil. 2013 Jan;25(1):4-15
references.pmid: 23279728
references.citation: Science. 2004 Mar 12;303(5664):1662-5
references.pmid: 15016999
references.citation: Am J Gastroenterol. 2000 May;95(5):1231-8
references.pmid: 10811333
references.citation: Gut Microbes. 2012 Sep-Oct;3(5):455-9
references.pmid: 22825495
references.citation: Biochimie. 2013 Mar;95(3):504-17
references.pmid: 22766017
references.citation: J Clin Invest. 2004 May;113(10):1408-18
references.pmid: 15146238
references.citation: J Appl Microbiol. 2003;95(1):86-91
references.pmid: 12807457
references.citation: Nature. 2012 Aug 9;488(7410):178-84
references.pmid: 22797518
references.citation: J Biol Chem. 1990 Jul 5;265(19):10925-8
references.pmid: 2358447
references.citation: Am J Gastroenterol. 2000 Dec;95(12):3503-6
references.pmid: 11151884
references.citation: Eur J Gastroenterol Hepatol. 2001 Oct;13(10):1143-7
references.pmid: 11711768
references.citation: J Clin Invest. 2002 May;109(9):1125-31
references.pmid: 11994399
references.citation: Semin Immunol. 2008 Feb;20(1):59-66
references.pmid: 18243016
references.citation: Science. 2005 Jun 10;308(5728):1635-8
references.pmid: 15831718
references.citation: Am J Gastroenterol. 2011 Feb;106(2):329-36
references.pmid: 21102570
references.citation: Am J Gastroenterol. 2009 Feb;104(2):404-10
references.pmid: 19174795
references.citation: Steroids. 1980 Jan;35(1):103-9
references.pmid: 7376208
references.citation: Science. 2005 Mar 25;307(5717):1915-20
references.pmid: 15790844
references.citation: J Biol Chem. 2004 May 28;279(22):23158-65
references.pmid: 15047713
references.citation: Sensors (Basel). 2013 Sep 06;13(9):11899-912
references.pmid: 24018955
references.citation: Exp Biol Med (Maywood). 2014 Nov;239(11):1489-504
references.pmid: 24951470
references.citation: Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6
references.pmid: 18240544
references.citation: J Clin Microbiol. 2005 Jul;43(7):3380-9
references.pmid: 16000463
references.citation: Am J Physiol Gastrointest Liver Physiol. 2013 Feb 1;304(3):G227-34
references.pmid: 23203158
references.citation: Ann Intern Med. 1981 Sep;95(3):257-82
references.pmid: 7023307
references.citation: Clin Infect Dis. 2008 Feb 15;46(4):594-9
references.pmid: 18205536
references.citation: J Dairy Sci. 1998 Jul;81(7):1818-24
references.pmid: 9710749
references.citation: Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):13-20
references.pmid: 18090652
references.citation: Proc Natl Acad Sci U S A. 2006 Mar 7;103(10 ):3920-5
references.pmid: 16473946
references.citation: Mutat Res. 2005 Jan;589(1):47-65
references.pmid: 15652226