title: Long-term results of adipose-derived stem cell therapy for the treatment of Crohn's fistula.
abstract: A previous phase II clinical trial of adipose-derived stem cell (ASC) therapy for fistulae associated with Crohn's disease, a devastating condition with a high recurrence rate, demonstrated safety and therapeutic potential with a 1-year sustained response. In the present study, 41 of the 43 phase II trial patients were followed for an additional year, regardless of response in the initial year. At 24 months, complete healing was observed in 21 of 26 patients (80.8%) in modified per protocol analysis and 27 of 36 patients (75.0%) in modified intention-to-treat analysis. No adverse events related to ASC administration were observed. Furthermore, complete closure after initial treatment was well-sustained. These results strongly suggest that autologous ASCs may be a novel treatment option for Crohn's fistulae.
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Cho
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Kyu Joo
authors.initials: KJ
authors.lastname: Park
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Sang Nam
authors.initials: SN
authors.lastname: Yoon
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Kee Ho
authors.initials: KH
authors.lastname: Song
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Do Sun
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Jung
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Mihyung
authors.initials: M
authors.lastname: Kim
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea.
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Jeong
authors.affiliation: Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; Department of Surgery, Seoul National University College of Medicine, Seoul, Korea; Department of Colon & Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea; Department of Surgery, Daehang Hospital, Seoul, Korea; Department of Surgery, Yeungnam University Medical Center, Daegu, Korea; Anterogen Co., Ltd., Seoul, Korea csyu@amc.seoul.kr.
authors.forename: Chang Sik
authors.initials: CS
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D064987:Cell- and Tissue-Based Therapy; D003424:Crohn Disease / Q000473:pathology / Q000628:therapy*; D005260:Female; D005402:Fistula / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing
keywords: Adipose-derived stem cells; Autologous stem cells; Complete closure of fistula; Crohn’s fistula; Sustained response
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