title: Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats.
abstract: Type 2 diabetes mellitus (T2DM) is a group of metabolic disorders characterized by hyperglycemia owing to insulin resistance and/or insulin deficiency. Current theories of T2DM pathophysiology include a decline in β-cells function, a defect in insulin signaling pathways, and a dysregulation of secretory function of adipocytes. This study aimed to investigate the effect of different antidiabetic drugs on serum levels of certain adipocytokines and nonesterified fatty acids (NEFA) in high-fat diet (HFD)/streptozotocin- (STZ-) induced diabetic rats. All treatments significantly decreased serum NEFA level. Metformin and sitagliptin increased serum adiponectin level, whereas they decreased serum leptin level. Glimepiride showed significant decline in serum levels of both adiponectin and leptin. All treatments remarkably ameliorated insulin resistance, suggested by an improvement of glycemic control, a significant reduction in homeostasis model assessment of insulin resistance (HOMA-IR), and a correction in lipid profile. Modulation of adipocytokines production (i.e., increased serum adiponectin and decreased serum leptin) may also underlie the improvement of insulin resistance and could be a possible mechanism for the beneficial cardiovascular effects of metformin and sitagliptin.
authors.affiliation: Biochemistry Department, Medical Research Institute, Alexandria University, 165 Elhorreya Avenue, P.O. Box 21561, Alexandria, Egypt.
authors.forename: Mohamed I
authors.initials: MI
authors.lastname: Saad
authors.affiliation: Biochemistry Department, Medical Research Institute, Alexandria University, 165 Elhorreya Avenue, P.O. Box 21561, Alexandria, Egypt.
authors.forename: Maher A
authors.initials: MA
authors.lastname: Kamel
authors.affiliation: Biochemistry Department, Medical Research Institute, Alexandria University, 165 Elhorreya Avenue, P.O. Box 21561, Alexandria, Egypt.
authors.forename: Mervat Y
authors.initials: MY
authors.lastname: Hanafi
references.citation: Curr Atheroscler Rep. 2011 Apr;13(2):115-22
references.pmid: 21170611
references.citation: Mol Metab. 2014 Jan 21;3(3):230-40
references.pmid: 24749053
references.citation: Nat Rev Immunol. 2011 Feb;11(2):85-97
references.pmid: 21252989
references.citation: Clin Sci (Lond). 2004 Dec;107(6):519-32
references.pmid: 15324298
references.citation: Lancet. 2014 Mar 22;383(9922):1068-83
references.pmid: 24315620
references.citation: Dig Dis Sci. 2009 Sep;54(9):1847-56
references.pmid: 19052866
references.citation: Diabetes Obes Metab. 2013 Oct;15(10):915-22
references.pmid: 23574533
references.citation: Nat Rev Mol Cell Biol. 2008 Mar;9(3):193-205
references.pmid: 18200017
references.citation: Clin Sci (Lond). 2012 Mar;122(6):253-70
references.pmid: 22117616
references.citation: Nat Clin Pract Endocrinol Metab. 2009 Mar;5(3):150-9
references.pmid: 19229235
references.citation: Diabetes. 2006 Mar;55(3):716-24
references.pmid: 16505235
references.citation: Lancet. 2011 Jul 9;378(9786):169-81
references.pmid: 21705072
references.citation: Br J Clin Pharmacol. 2010 Nov;70(5):631-44
references.pmid: 20831513
references.citation: Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36
references.pmid: 22064493
references.citation: Mol Med. 2008 Nov-Dec;14(11-12):741-51
references.pmid: 19009016
references.citation: Clin Chim Acta. 2007 Jan;375(1-2):20-35
references.pmid: 16956601
references.citation: FEBS Lett. 2003 Jul 3;546(1):45-50
references.pmid: 12829235
references.citation: Lancet. 2006 Nov 11;368(9548):1696-705
references.pmid: 17098089
references.citation: Drugs. 2003;63(18):1879-94
references.pmid: 12930161
references.citation: Atherosclerosis. 2013 Jul;229(1):23-9
references.pmid: 23643052
references.citation: Curr Vasc Pharmacol. 2010 May;8(3):327-37
references.pmid: 19485923
references.citation: J Endocrinol. 2010 Jan;204(1):1-11
references.pmid: 19770178
references.citation: Acta Physiol (Oxf). 2014 Apr;210(4):733-53
references.pmid: 24495317