title: Corneal epithelial thickness mapping using Fourier-domain optical coherence tomography for detection of form fruste keratoconus.
abstract: OBJECTIVE
  To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus.
  
  
  METHODS
  French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France.
  
  
  METHODS
  Retrospective comparative study.
  
  
  METHODS
  Eyes with normal corneas, form fruste keratoconus, moderate keratoconus, or severe keratoconus were assessed using Fourier-domain OCT (RTVue 5.5), scanning-slit corneal topography (Orbscan IIz), and rotating Scheimpflug camera (Pentacam Comprehensive Eye Scanner). Several parameters provided by the software or derived from elevation maps, OCT pachymetric maps, and OCT epithelium parameters were evaluated and compared between the 4 groups.
  
  
  RESULTS
  The study involved 145 eyes. There were no significant differences in the keratometry (K) value, inferior-superior value, keratoconus index, central K index, and topographic keratoconus classification indices between the form fruste keratoconus group and the control group (P > .05). Form fruste keratoconic corneas had less epithelial thickness in the thinnest corneal zone than normal corneas, and greater epithelial thickness in the thinnest corneal zone than keratoconic corneas (P < .005). The epithelial thickness in the thinnest corneal zone in form fruste corneas was located inferiorly (P < .005) and corresponded with the zone of minimum epithelial thickness and maximum posterior elevation (P < .005). The receiver operating characteristic curve analysis showed good overall predictive accuracy of the epithelial thickness in the thinnest corneal zone, with a 52 μm threshold value for discriminating form fruste keratoconic corneas from normal corneas.
  
  
  CONCLUSIONS
  The epithelial thickness in the thinnest corneal zone and its location provided by the OCT epithelial mapping might be useful for the early diagnosis of form fruste keratoconus.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France. Electronic address: ctemstet@gmail.com.
authors.forename: Cyril
authors.initials: C
authors.lastname: Temstet
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Otman
authors.initials: O
authors.lastname: Sandali
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Nacim
authors.initials: N
authors.lastname: Bouheraoua
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Taous
authors.initials: T
authors.lastname: Hamiche
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Alice
authors.initials: A
authors.lastname: Galan
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Sanharawi
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Elena
authors.initials: E
authors.lastname: Basli
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Laroche
authors.affiliation: From Centre Hospitalier National d'Ophtalmologie des XV-XX (Temstet, Sandali, Bouheraoua, Hamiche, Galan, El Sanharawi, Basli, Laroche, Borderie), Pierre et Marie Curie University, and Research Team 968 (Bouheraoua, Laroche, Borderie), Institut de la Vision, Paris, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Borderie
mesh_terms: D000328:Adult; D063171:Corneal Pachymetry; D019781:Corneal Topography; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis*; D008297:Male; D009929:Organ Size; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence