title: Catatonia in an adolescent with velo-cardio-facial syndrome.
abstract: Velo-cardio-facial syndrome (VCFS) is the most common microdeletion syndrome in humans and is probably the most frequent genetic cause of psychosis currently known. Many psychiatric disorders have been reported to occur in people with VCFS including, but not limited to schizophrenia, unipolar and bipolar mood disorders (with or without psychotic features), schizoaffective disorder, psychosis NOS, social phobia, generalized and separation anxiety, obsessive-compulsive disorder, autism spectrum disorder, cognitive impairment, and ADHD. This report describes the psychiatric onset and development of catatonia in an adolescent female with VCFS that was undiagnosed until 15 years of age. Catatonia may be a relatively common presentation in people with VCFS with treatment-refractory psychiatric manifestations.
authors.affiliation: Lucio Bini Mood Disorders Center, New York, New York.|Department of Child and Adolescent Psychiatry, NYU Medical Center, New York, New York.|The Virtual Center for Velo-Cardio-Facial Syndrome, Inc., Manlius, New York.
authors.forename: Gianni L
authors.initials: GL
authors.lastname: Faedda
authors.affiliation: Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Lee E
authors.initials: LE
authors.lastname: Wachtel
authors.affiliation: The Virtual Center for Velo-Cardio-Facial Syndrome, Inc., Manlius, New York.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Higgins
authors.affiliation: The Virtual Center for Velo-Cardio-Facial Syndrome, Inc., Manlius, New York.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Shprintzen
mesh_terms: D000293:Adolescent; D002389:Catatonia / Q000235:genetics*; D004062:DiGeorge Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics
keywords: 22q11.2 deletion; catatonia; psychosis; velo-cardio-facial syndrome