title: Colorectal neoplasia pathways: state of the art.
abstract: Colorectal cancer (CRC) is a heterogeneous disease and each CRC possesses a unique molecular tumor profile. The main pathways of oncogenesis are the chromosomal instability, microsatellite instability and serrated neoplasia pathway. Sessile serrated adenomas/polyps (SSA/Ps) may be the precursor lesions of CRC arising via the serrated neoplasia pathway. This has led to a paradigm shift because all SSA/Ps should be detected and resected during colonoscopy. The ability to accurately detect and resect only those polyps with a malignant potential could result in safer and cost-effective practice. Optimization of the endoscopic classification systems is however needed to implement targeted prevention methods.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, Room C2-231, Amsterdam 1105 AZ The Netherlands.
authors.forename: Joep Evert Godfried
authors.initials: JE
authors.lastname: IJspeert
authors.affiliation: Laboratory for Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, Academic Medical Center (AMC), Meibergdreef 9, Room G2-131, Amsterdam 1105 AZ, The Netherlands.
authors.forename: Jan Paul
authors.initials: JP
authors.lastname: Medema
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, Room C2-115, Amsterdam 1105 AZ, The Netherlands. Electronic address: e.dekker@amc.uva.nl.
authors.forename: Evelien
authors.initials: E
authors.lastname: Dekker
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D063646:Carcinogenesis / Q000473:pathology*; D003111:Colonic Polyps / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D006801:Humans; D053842:Microsatellite Instability; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D012307:Risk Factors
keywords: Chromosomal instability; Colonoscopy; Colorectal cancer; Colorectal polyps; Microsatellite instability; Serrated neoplasia pathway