title: Hybrid protein-synthetic polymer nanoparticles for drug delivery.
abstract: Among the most common nanoparticulate systems, the polymeric nanocarriers have a number of key benefits, which give a great choice of delivery platforms. Nevertheless, polymeric nanoparticles possess some limitations that include use of toxic solvents in the production process, polymer degradation, drug leakage outside the diseased tissue, and polymer cytotoxicity. The combination of polymers of biological and synthetic origin is an appealing modern strategy for the production of novel nanocarriers with unprecedented properties. Proteins' interface can play an important role in determining bioactivity and toxicity and gives perspective for future development of the polymer-based nanoparticles. The design of hybrid constructs composed of synthetic polymer and biological molecules such as proteins can be considered as a straightforward tool to integrate a broad spectrum of properties and biofunctions into a single device. This review discusses hybrid protein-synthetic polymer nanoparticles with different structures and levels in complexity and functionality, in view of their applications as drug delivery systems.
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria. Electronic address: koseva@polymer.bas.bg.
authors.forename: Neli S
authors.initials: NS
authors.lastname: Koseva
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria; Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rydz
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Ekaterina V
authors.initials: EV
authors.lastname: Stoyanova
authors.affiliation: Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria.
authors.forename: Violeta A
authors.initials: VA
authors.lastname: Mitova
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011091:Polyesters; D011506:Proteins; D011099:Polyglutamic Acid; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: Drug delivery; Hybrid nanoparticles; Peptides; Proteins; Synthetic polymers