title: Significance of circulating and crevicular matrix metalloproteinase-9 in rheumatoid arthritis-chronic periodontitis association.
abstract: In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n = 21), active RA (n = 16), CP (n = 14), and RA-CP association (n = 12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.
authors.affiliation: Department of Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
authors.forename: Isabela
authors.initials: I
authors.lastname: Silosi
authors.affiliation: Department of Physiology, University Titu Maiorescu of Bucharest, Faculty of Medicine, 187 Calea Vacaresti Street, 004051 Bucharest, Romania.
authors.forename: Manole
authors.initials: M
authors.lastname: Cojocaru
authors.affiliation: Department of Biochemistry, University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania.
authors.forename: Lili
authors.initials: L
authors.lastname: Foia
authors.affiliation: Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
authors.forename: Mihail Virgil
authors.initials: MV
authors.lastname: Boldeanu
authors.affiliation: Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
authors.forename: Florin
authors.initials: F
authors.lastname: Petrescu
authors.affiliation: Department of Periodontology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
authors.forename: Petra
authors.identifier: 0000-0003-3469-8008
authors.initials: P
authors.lastname: Surlin
authors.affiliation: Department of Medical Semiology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
authors.forename: Viorel
authors.initials: V
authors.lastname: Biciusca
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000378:metabolism*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D020780:Matrix Metalloproteinase 9
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