title: 1H nuclear magnetic resonance-based metabolomic study on efficacy of Qingrehuatan decoction against abundant phlegm-heat syndrome in young adults with essential hypertension.
abstract: OBJECTIVE
  To observe the influence of Qingrehuatan decoction (QRHT) on serum metabolic profile in young essential hypertension (YEH) patients with abundant phlegm-heat syndrome and provide a basis for treatment with the decoction.
  
  
  METHODS
  Twelve male YEH patients were randomly selected and serum samples were collected for examination before and after 4 weeks of the treatment with QRHT. Twelve healthy males were randomly selected and their serum samples were collected as a control. All serum samples were detected using metabolomic technology with 1H nuclear magnetic resonance. Differences in metabolites were studied by principal component analysis and partial least squares-discriminate analysis, which produced scores and loadings plots.
  
  
  RESULTS
  After 4 weeks of treatment, serum substances could be distinguished between the YEH patients with abundant phlegm-heat syndrome and the control patients. The specific serum endog- enous metabolites tended to improve after the treatment. QRHT can appropriately increase the levels of glucose, lactic acid, citric acid, high-density lipoprotein, phosphatidylcholine, glycerophosphate choline, hydroxybutyrate, alanine, and glutamate. QRHT could also decrease the levels of low-density lipoprotein/very low-density lipoprotein, lipids, N-acetyl glycoprotein, and O-acetyl glycoprotein.
  
  
  CONCLUSIONS
  QRHT can effectively ameliorate metabolic disorders in YEH Patients with abundant phlegm-heat syndrome. 1H NMR-based metabolomic technology can provide an objective basis for the treatment of YEH patients with abundant phlegm-heat syndrome using QRHT.
authors.forename: Xuanchao
authors.initials: X
authors.lastname: Feng
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Yuguang
authors.initials: Y
authors.lastname: Chu
authors.forename: Bai
authors.initials: B
authors.lastname: Du
authors.forename: Mei
authors.initials: M
authors.lastname: Su
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Wang
authors.forename: Chunying
authors.initials: C
authors.lastname: Jiang
authors.forename: Yuanhui
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics; D009093:Mucus / Q000378:metabolism; D044967:Serum / Q000737:chemistry* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal