title: Diagnosis and therapeutic options for peripheral vasculitic neuropathy.
abstract: Vasculitis can affect the peripheral nervous system alone (nonsystemic vasculitic neuropathy) or can be a part of primary or secondary systemic vasculitis. In cases of pre-existing systemic vasculitis, the diagnosis can easily be made, whereas suspected vasculitic neuropathy as initial or only manifestation of vasculitis requires careful clinical, neurophysiological, laboratory and histopathological workout. The typical clinical syndrome is mononeuropathia multiplex or asymmetric neuropathy, but distal-symmetric neuropathy can frequently be seen. Standard treatments include steroids, azathioprine, methotrexate and cyclophosphamide. More recently the B-cell antibody rituximab and intravenous immunoglobulins have shown to be effective in some vasculitic neuropathy types.
authors.affiliation: Department of Neurology, KKH Gummersbach, Wilhelm-Breckow-Allee 20, 51643 Gummersbach, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Blaes
keywords: autoantibodies; polyneuropathy; rheumatic diseases; treatment; vasculitic neuropathy
references.citation: BMC Gastroenterol. 2008 Feb 27;8:7
references.pmid: 18304354
references.citation: Medicine (Baltimore). 2011 Jan;90(1):19-27
references.pmid: 21200183
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:779-86
references.pmid: 16127015
references.citation: Rheumatology (Oxford). 2001 Feb;40(2):178-84
references.pmid: 11257154
references.citation: Ann Neurol. 1985 Aug;18(2):251-7
references.pmid: 4037764
references.citation: Autoimmun Rev. 2011 Nov;11(1):48-55
references.pmid: 21821153
references.citation: Intern Med. 2013;52(15):1737-40
references.pmid: 23903509
references.citation: Ann Rheum Dis. 2010 Oct;69(10):1744-50
references.pmid: 20448283
references.citation: Rheumatol Int. 2008 Aug;28(10):951-7
references.pmid: 18528693
references.citation: Sarcoidosis Vasc Diffuse Lung Dis. 2003 Jun;20(2):118-25
references.pmid: 12870721
references.citation: Medicine (Baltimore). 1999 Sep;78(5):292-308
references.pmid: 10499071
references.citation: Rheumatology (Oxford). 2011 Dec;50(12):2214-22
references.pmid: 21890618
references.citation: Neurol Clin. 1997 Nov;15(4):849-63
references.pmid: 9367968
references.citation: Transfus Apher Sci. 2010 Jun;42(3):247-51
references.pmid: 20382569
references.citation: Brain. 1996 Oct;119 ( Pt 5):1441-8
references.pmid: 8931569
references.citation: Hum Pathol. 2014 Feb;45(2):427-30
references.pmid: 24289971
references.citation: Lancet. 2012 Jan 28;379(9813):348-60
references.pmid: 21868085
references.citation: J Peripher Nerv Syst. 2006 Mar;11(1):20-9
references.pmid: 16519779
references.citation: Arthritis Rheum. 2007 Dec 15;57(8):1520-9
references.pmid: 18050172
references.citation: J Clin Neuromuscul Dis. 2000 Mar;1(3):117-23
references.pmid: 19078569
references.citation: Ann Rheum Dis. 2003 Dec;62(12):1221-3
references.pmid: 14644864
references.citation: Clin Rheumatol. 2010 Aug;29(8):855-60
references.pmid: 20195878
references.citation: Medicine (Baltimore). 2004 Sep;83(5):280-291
references.pmid: 15342972
references.citation: Rheumatology (Oxford). 2014 May;53(5):834-8
references.pmid: 24369416
references.citation: JAMA Neurol. 2013 Apr;70(4):502-5
references.pmid: 23440288
references.citation: Ann Neurol. 1979 May;5(5):437-44
references.pmid: 223493
references.citation: Arthritis Rheum. 2012 Mar;64(3):843-53
references.pmid: 22147661
references.citation: Rev Med Interne. 2014 Feb;35(2):112-20
references.pmid: 24290030
references.citation: United European Gastroenterol J. 2014 Jun;2(3):165-72
references.pmid: 25360299
references.citation: JAMA. 2010 Dec 1;304(21):2381-8
references.pmid: 21060104
references.citation: Curr Rheumatol Rep. 2013 Aug;15(8):348
references.pmid: 23794082
references.citation: J Clin Neurosci. 2012 Oct;19(10):1392-6
references.pmid: 22901506
references.citation: Intern Med. 2013;52(4):497-502
references.pmid: 23411709
references.citation: Clin Neuropathol. 2008 Mar-Apr;27(2):96-105
references.pmid: 18402389
references.citation: Neurology. 1997 Dec;49(6):1641-5
references.pmid: 9409360
references.citation: Clin Exp Neurol. 1989;26:99-112
references.pmid: 2642143
references.citation: Clin Exp Rheumatol. 2008 May-Jun;26(3 Suppl 49):S118-30
references.pmid: 18799069
references.citation: Clin J Am Soc Nephrol. 2010 Mar;5(3):445-53
references.pmid: 20093349
references.citation: Brain. 1996 Aug;119 ( Pt 4):1091-8
references.pmid: 8813273
references.citation: Clin Rheumatol. 2000;19(3):242-4
references.pmid: 10870665
references.citation: Intern Med. 2003 Nov;42(11):1100-3
references.pmid: 14686749
references.citation: Arthritis Rheum. 2007 Dec 15;57(8):1473-80
references.pmid: 18050165
references.citation: Semin Arthritis Rheum. 2011 Oct;41(2):203-11
references.pmid: 21641018
references.citation: Neurology. 2013 Apr 30;80(18):1693-7
references.pmid: 23576624
references.citation: Clin Dev Immunol. 2012;2012:315167
references.pmid: 22927871
references.citation: J Peripher Nerv Syst. 2010 Sep;15(3):176-84
references.pmid: 21040139
references.citation: J Neuropathol Exp Neurol. 2011 May;70(5):340-8
references.pmid: 21487308
references.citation: Arthritis Rheum. 2003 Oct 15;49(5):709-15
references.pmid: 14558058
references.citation: Curr Opin Neurol. 2012 Oct;25(5):573-85
references.pmid: 22918487
references.citation: Mayo Clin Proc. 1972 Jul;47(7):461-75
references.pmid: 4402730
references.citation: Neurologist. 2010 Sep;16(5):287-97
references.pmid: 20827117
references.citation: Clin Rheumatol. 2008 Jul;27(7):841-4
references.pmid: 18084807
references.citation: Acta Med Scand. 1968 Jul-Aug;184(1-2):69-77
references.pmid: 4387508
references.citation: J Clin Neuromuscul Dis. 2007 Dec;9(2):285-90
references.pmid: 18090680
references.citation: Muscle Nerve. 1991 Feb;14(2):152-6
references.pmid: 1847991
references.citation: Brain. 2012 Oct;135(Pt 10):3074-88
references.pmid: 23065793
references.citation: Neurology. 1999 Dec 10;53(9):2113-21
references.pmid: 10599791
references.citation: Arthritis Rheum. 2010 Apr;62(4):1186-97
references.pmid: 20131268
references.citation: Ann Endocrinol (Paris). 2008 Dec;69(6):517-22
references.pmid: 18774123
references.citation: J Rheumatol. 2002 Jul;29(7):1408-14
references.pmid: 12136898
references.citation: Lancet Neurol. 2005 Dec;4(12):853-65
references.pmid: 16297843
references.citation: Autoimmun Rev. 2008 Oct;8(1):56-8
references.pmid: 18703170
references.citation: Rev Neurol (Paris). 2007 Jan;163(1):103-6
references.pmid: 17304181
references.citation: Neurology. 2003 Sep 9;61(5):623-30
references.pmid: 12963752
references.citation: Z Rheumatol. 2008 Mar;67(2):137-43; quiz 144
references.pmid: 18309498
references.citation: Semin Arthritis Rheum. 1995 Aug;25(1):28-34
references.pmid: 8525388
references.citation: J Neurol. 2005 Jun;252(6):633-41
references.pmid: 15806339
references.citation: J Clin Neuromuscul Dis. 2011 Jun;12(4):231-4
references.pmid: 22361522
references.citation: J Autoimmun. 2014 Feb-Mar;48-49:84-9
references.pmid: 24485157
references.citation: J Neurol Neurosurg Psychiatry. 2008 Dec;79(12):1376-81
references.pmid: 18819942
references.citation: Ann Rheum Dis. 2008 Mar;67(3):283-7
references.pmid: 17644544
references.citation: Rev Neurol. 2004 Apr 1-15;38(7):619-24
references.pmid: 15098181
references.citation: Rheumatology (Oxford). 2007 Jul;46(7):1087-91
references.pmid: 17519271
references.citation: Pol J Pathol. 2012 Dec;63(4):261-6
references.pmid: 23359196
references.citation: Brain. 1999 Mar;122 ( Pt 3):427-39
references.pmid: 10094252
references.citation: N Engl J Med. 2010 Jul 15;363(3):221-32
references.pmid: 20647199
references.citation: Ann Rheum Dis. 2003 May;62(5):407-13
references.pmid: 12695150