title: Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales.
abstract: Microvascular network remodelling is a common denominator for multiple pathologies and involves both angiogenesis, defined as the sprouting of new capillaries, and network patterning associated with the organization and connectivity of existing vessels. Much of what we know about microvascular remodelling at the network, cellular and molecular scales has been derived from reductionist biological experiments, yet what happens when the experiments provide incomplete (or only qualitative) information? This review will emphasize the value of applying computational approaches to advance our understanding of the underlying mechanisms and effects of microvascular remodelling. Examples of individual computational models applied to each of the scales will highlight the potential of answering specific questions that cannot be answered using typical biological experimentation alone. Looking into the future, we will also identify the needs and challenges associated with integrating computational models across scales.
authors.affiliation: Department of Biomedical Engineering , Tulane University , 500 Lindy Boggs Energy Center, New Orleans, LA 70118 , USA.
authors.forename: Walter L
authors.initials: WL
authors.lastname: Murfee
authors.affiliation: Department of Biomedical Engineering , Tulane University , 500 Lindy Boggs Energy Center, New Orleans, LA 70118 , USA.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Sweat
authors.affiliation: Department of Mechanical Engineering , Chiba University , 1-33 Yayoi, Inage, Chiba 263-8522 , Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Tsubota
authors.affiliation: Department of Biomedical Engineering , Johns Hopkins University , 3400 North Charles Street, Baltimore, MD 21218 , USA ; Department of Materials Science and Engineering , Johns Hopkins University , 3400 North Charles Street, Baltimore, MD 21218 , USA ; Institute for Computational Medicine , Johns Hopkins University , 3400 North Charles Street, Baltimore, MD 21218 , USA.
authors.forename: Feilim
authors.initials: F
authors.lastname: Mac Gabhann
authors.affiliation: Department of Biomedical Engineering , Tulane University , 500 Lindy Boggs Energy Center, New Orleans, LA 70118 , USA.
authors.forename: Damir
authors.initials: D
authors.lastname: Khismatullin
authors.affiliation: Department of Biomedical Engineering , University of Virginia , 415 Lane Road, Charlottesville, VA 22903 , USA.
authors.forename: Shayn M
authors.initials: SM
authors.lastname: Peirce
keywords: agent-based model; angiogenesis; computational fluid dynamics; hypertension; microcirculation; multiscale computational model
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