title: Baseline blood levels of manganese, lead, cadmium, copper, and zinc in residents of Beijing suburb.
abstract: Baseline blood concentrations of metals are important references for monitoring metal exposure in environmental and occupational settings. The purpose of this study was to determine the blood levels of manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), and cadmium (Cd) among the residents (aged 12-60 years old) living in the suburb southwest of Beijing in China and to compare the outcomes with reported values in various developed countries. Blood samples were collected from 648 subjects from March 2009 to February 2010. Metal concentrations in the whole blood were determined by ICP-MS. The geometric means of blood levels of Mn, Cu, Zn, Pb and Cd were 11.4, 802.4, 4665, 42.6, and 0.68 µg/L, respectively. Male subjects had higher blood Pb than the females, while the females had higher blood Mn and Cu than the males. There was no gender difference for blood Cd and Zn. Smokers had higher blood Cu, Zn, and Cd than nonsmokers. There were significant age-related differences in blood levels of all metals studied; subjects in the 17-30 age group had higher blood levels of Mn, Pb, Cu, and Zn, while those in the 46-60 age group had higher Cd than the other age groups. A remarkably lower blood level of Cu and Zn in this population as compared with residents of other developed countries was noticed. Based on the current study, the normal reference ranges for the blood Mn were estimated to be 5.80-25.2 μg/L; for blood Cu, 541-1475 μg/L; for blood Zn, 2349-9492 μg/L; for blood Pb, <100 μg/L; and for blood Cd, <5.30 μg/L in the general population living in Beijing suburbs.
authors.affiliation: Department of Occupational Diseases Control and Prevention, Fengtai Center for Disease Control and Prevention, Beijing 100071, PR China. Electronic address: Longlian57@163.com.
authors.forename: Long-Lian
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: Department of Occupational Diseases Control and Prevention, Fengtai Center for Disease Control and Prevention, Beijing 100071, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.affiliation: Institute for Occupational Health and Poison Control in China Center for Disease Prevention and Control, Beijing 100050, PR China.
authors.forename: Ya-Juan
authors.initials: YJ
authors.lastname: Pan
authors.affiliation: Institute for Occupational Health and Poison Control in China Center for Disease Prevention and Control, Beijing 100050, PR China.
authors.forename: Chun-Guang
authors.initials: CG
authors.lastname: Ding
authors.affiliation: Department of Occupational Diseases Control and Prevention, Fengtai Center for Disease Control and Prevention, Beijing 100071, PR China.
authors.forename: Da-Yong
authors.initials: DY
authors.lastname: Xu
authors.affiliation: Institute for Occupational Health and Poison Control in China Center for Disease Prevention and Control, Beijing 100050, PR China.
authors.forename: Chuan-Feng
authors.initials: CF
authors.lastname: Huang
authors.affiliation: Institute for Occupational Health and Poison Control in China Center for Disease Prevention and Control, Beijing 100050, PR China.
authors.forename: Xing-Fu
authors.initials: XF
authors.lastname: Pan
authors.affiliation: School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: wzheng@purdue.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002681:China; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008670:Metals / Q000097:blood*; D008875:Middle Aged; D012907:Smoking; D013383:Suburban Population; D055815:Young Adult
chemical_list: D008670:Metals
keywords: Cadmium; Cooper; Lead; Manganese; Reference range; Resident; Whole blood; Zinc
references.citation: J Trace Elem Med Biol. 2011 Jan;25(1):19-26
references.pmid: 21242073
references.citation: Chemosphere. 2007 Nov;70(1):155-64
references.pmid: 17707880
references.citation: Biol Trace Elem Res. 1998 Jan;61(1):61-70
references.pmid: 9498332
references.citation: Neurotoxicology. 2012 Aug;33(4):881-6
references.pmid: 22202748
references.citation: Toxicol Sci. 2001 May;61(1):107-14
references.pmid: 11294981
references.citation: Pharmacol Ther. 2012 Feb;133(2):177-88
references.pmid: 22115751
references.citation: Neurology. 2006 May 23;66(10):1476-84
references.pmid: 16717205
references.citation: J Clin Chem Clin Biochem. 1987 May;25(5):337-42
references.pmid: 3612033
references.citation: Cent Eur J Public Health. 2005 Dec;13(4):202-7
references.pmid: 16419386
references.citation: Aust N Z J Public Health. 2013 Jun;37(3):233-7
references.pmid: 23731105
references.citation: Cent Eur J Public Health. 2000 May;8(2):117-9
references.pmid: 10857051
references.citation: J Toxicol Environ Health A. 2010;73(13-14):878-87
references.pmid: 20563921
references.citation: Br Med Bull. 2003;68:167-82
references.pmid: 14757716
references.citation: Int J Hyg Environ Health. 2013 Jun;216(3):243-9
references.pmid: 22748699
references.citation: Int J Occup Med Environ Health. 2001;14(2):189-92
references.pmid: 11548070
references.citation: Environ Sci Pollut Res Int. 2003;10(3):192-8
references.pmid: 12846382
references.citation: J Trace Elem Med Biol. 2006;20(4):253-62
references.pmid: 17098585
references.citation: J Occup Environ Med. 2010 Apr;52(4):407-14
references.pmid: 20357679
references.citation: Sci Total Environ. 1997 Sep 26;204(2):147-60
references.pmid: 9301099
references.citation: Int J Hyg Environ Health. 2012 Feb;215(2):185-90
references.pmid: 21964309
references.citation: Ann Ist Super Sanita. 2005;41(2):181-7
references.pmid: 16244391
references.citation: J Trace Elem Med Biol. 2006;20(1):3-18
references.pmid: 16632171
references.citation: Int J Hyg Environ Health. 2002 May;205(4):297-308
references.pmid: 12068749
references.citation: Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Sep;48(9):784-90
references.pmid: 25492289
references.citation: Environ Res. 2002 May;89(1):72-84
references.pmid: 12051788
references.citation: Int J Hyg Environ Health. 2004 Jan;207(1):69-73
references.pmid: 14762976
references.citation: J Toxicol Clin Toxicol. 1999;37(2):279-92
references.pmid: 10382562
references.citation: Int J Hyg Environ Health. 2006 Jul;209(4):359-66
references.pmid: 16740414
references.citation: Curr Alzheimer Res. 2012 Jun;9(5):563-73
references.pmid: 22272628
references.citation: Toxicol Lett. 2012 Sep 3;213(2):211-9
references.pmid: 22796588
references.citation: Sci Total Environ. 1992 Jun 9;120(1-2):63-79
references.pmid: 1641640
references.citation: Environ Health Perspect. 2004 Jul;112(10):1099-103
references.pmid: 15238284
references.citation: NMR Biomed. 2004 Dec;17(8):544-53
references.pmid: 15617053
references.citation: Neurosci Lett. 2011 Feb 18;490(1):16-20
references.pmid: 21167913
references.citation: Ann Nutr Metab. 2013;62 Suppl 1:8-17
references.pmid: 23689109
references.citation: Sci Total Environ. 2009 Jun 15;407(13):3986-93
references.pmid: 19395068
references.citation: Int J Hyg Environ Health. 2011 Mar;214(2):102-9
references.pmid: 20965782
references.citation: Food Chem Toxicol. 2013 Jul;57:161-9
references.pmid: 23537601
references.citation: Sci Total Environ. 1992 Jun 9;120(1-2):39-61
references.pmid: 1641639
references.citation: Free Radic Biol Med. 1995 Dec;19(6):849-52
references.pmid: 8582658
references.citation: Biol Trace Elem Res. 2010 Jan;133(1):1-11
references.pmid: 19468697
references.citation: Sci Total Environ. 1999 May 19;229(3):209-15
references.pmid: 10418170
references.citation: Biol Trace Elem Res. 2008 Summer;123(1-3):277-80
references.pmid: 18259694
references.citation: Rev Esp Fisiol. 1985 Dec;41(4):463-70
references.pmid: 4095368
references.citation: Neurotoxicology. 2011 Jan;32(1):1-8
references.pmid: 20946915
references.citation: Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Feb;48(2):109-13
references.pmid: 24746004
references.citation: Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Feb;48(2):91-6
references.pmid: 24746001
references.citation: Int J Hyg Environ Health. 2012 Jul;215(4):449-57
references.pmid: 22341685