title: HBV reactivation in a HBsAg-negative patient with multiple myeloma treated with prednisolone maintenance therapy after autologous HSCT.
abstract: Hepatitis B virus (HBV) reactivation has previously occurred in hepatitis B surface antigen-negative patients with malignant lymphoma who received rituximab-based combination chemotherapy. However, few reports have described cases of HBV reactivation in patients with multiple myeloma thus far. We report a case of HBV reactivation in a patient with multiple myeloma treated with chemotherapy, autologous hematopoietic stem cell transplantation, and maintenance steroid therapy. For the HBV reactivation, the patient was treated with the antiviral agent entecavir. The clinical symptoms and laboratory findings improved after 3 months. Further studies should target the identification of patients at high risk of HBV reactivation in multiple myeloma treated with autologous hematopoietic stem cell transplantation and steroid therapy for maintenance and establish viral prophylaxis strategies, especially in Korea, in which HBV infection is endemic.
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Ha Ra
authors.initials: HR
authors.lastname: Gu
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Dong-Yeop
authors.initials: DY
authors.lastname: Shin
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Hong Seok
authors.initials: HS
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Chae Ho
authors.initials: CH
authors.lastname: Moon
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Su Cheol
authors.initials: SC
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Kang
keywords: Chemotherapy; HBV reactivation; Multiple myeloma; Prednisolone; Transplantation
references.citation: Korean J Gastroenterol. 2010 Apr;55(4):266-9
references.pmid: 20389182
references.citation: Hepatology. 2007 Feb;45(2):507-39
references.pmid: 17256718
references.citation: Biol Blood Marrow Transplant. 2007 Apr;13(4):463-8
references.pmid: 17382252
references.citation: Korean J Intern Med. 2007 Dec;22(4):237-43
references.pmid: 18309681
references.citation: Leuk Lymphoma. 2002 Nov;43(11):2159-63
references.pmid: 12533042
references.citation: Korean J Intern Med. 2013 Jul;28(4):413-9
references.pmid: 23864799
references.citation: J Clin Oncol. 2009 Feb 1;27(4):605-11
references.pmid: 19075267
references.citation: Bone Marrow Transplant. 1999 Dec;24(11):1243-4
references.pmid: 10642815
references.citation: Gastroenterology. 1975 Jan;68(1):105-12
references.pmid: 1054319
references.citation: J Infect Dis. 2010 Jul 15;202(2):192-201
references.pmid: 20533878
references.citation: Virology. 1988 Dec;167(2):630-3
references.pmid: 3201757