title: Regulation of bacterial virulence by Csr (Rsm) systems.
abstract: Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens.
authors.affiliation: Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Vakulskas
authors.affiliation: Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA.
authors.forename: Anastasia H
authors.initials: AH
authors.lastname: Potts
authors.affiliation: Department of Biochemistry and Molecular Biology, Center for RNA Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Babitzke
authors.affiliation: Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA Department of Microbiology, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Brian M M
authors.initials: BM
authors.lastname: Ahmer
authors.affiliation: Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, USA tromeo@ufl.edu.
authors.forename: Tony
authors.initials: T
authors.lastname: Romeo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D020563:Gammaproteobacteria / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D015964:Gene Expression Regulation, Bacterial; D053263:Gene Regulatory Networks; D016680:Genome, Bacterial; D006801:Humans; D008954:Models, Biological; D010944:Plants / Q000382:microbiology; D017433:Protein Structure, Secondary; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D037521:Virulence Factors
references.citation: Annu Rev Biophys. 2012;41:343-70
references.pmid: 22577823
references.citation: J Bacteriol. 2012 Jan;194(1):79-89
references.pmid: 22037401
references.citation: Mol Microbiol. 2008 Oct;70(1):236-57
references.pmid: 18713317
references.citation: Cold Spring Harb Perspect Med. 2013 Oct 01;3(10):a016717
references.pmid: 24086068
references.citation: Annu Rev Microbiol. 2013;67:83-112
references.pmid: 23799815
references.citation: Mol Microbiol. 1999 Aug;33(3):669-70
references.pmid: 10417657
references.citation: PLoS One. 2013;8(1):e54248
references.pmid: 23372695
references.citation: Nature. 2002 Jan 31;415(6871):545-9
references.pmid: 11823863
references.citation: Biosci Biotechnol Biochem. 2004 Aug;68(8):1758-67
references.pmid: 15322361
references.citation: Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14591-6
references.pmid: 18799744
references.citation: Curr Opin Microbiol. 1999 Feb;2(1):30-4
references.pmid: 10047559
references.citation: J Bacteriol. 2004 Jul;186(14):4466-75
references.pmid: 15231778
references.citation: Microbiology (Reading). 2007 Aug;153(Pt 8):2689-2699
references.pmid: 17660433
references.citation: Microbiology (Reading). 2006 Feb;152(Pt 2):405-418
references.pmid: 16436429
references.citation: Nat Rev Microbiol. 2007 Feb;5(2):157-61
references.pmid: 17191074
references.citation: FEMS Microbiol Rev. 2001 Aug;25(4):365-404
references.pmid: 11524130
references.citation: Mol Microbiol. 2004 Jan;51(1):15-32
references.pmid: 14651608
references.citation: Annu Rev Microbiol. 2012;66:493-520
references.pmid: 22746331
references.citation: Nature. 2014 May 29;509(7502):588-92
references.pmid: 24828038
references.citation: J Bacteriol. 2008 Jul;190(13):4736-48
references.pmid: 18456804
references.citation: Appl Environ Microbiol. 2009 Oct;75(20):6568-80
references.pmid: 19717631
references.citation: FEMS Microbiol Rev. 2005 Jan;29(1):83-98
references.pmid: 15652977
references.citation: J Bacteriol. 1993 Aug;175(15):4744-55
references.pmid: 8393005
references.citation: J Biol Chem. 2008 Apr 11;283(15):9933-44
references.pmid: 18256026
references.citation: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8487-92
references.pmid: 16687478
references.citation: Mol Microbiol. 2006 Nov;62(3):631-40
references.pmid: 16995895
references.citation: Phys Biol. 2013 Aug;10(4):046008
references.pmid: 23883670
references.citation: J Bacteriol. 1997 Jun;179(11):3711-20
references.pmid: 9171421
references.citation: Microbiology (Reading). 2011 Sep;157(Pt 9):2504-2514
references.pmid: 21680637
references.citation: J Bacteriol. 2001 Aug;183(16):4876-85
references.pmid: 11466291
references.citation: Appl Environ Microbiol. 1998 Sep;64(9):3127-33
references.pmid: 9726849
references.citation: Mol Microbiol. 2000 Feb;35(3):635-46
references.pmid: 10672185
references.citation: Infect Immun. 2009 Sep;77(9):3552-68
references.pmid: 19581394
references.citation: Microbiology (Reading). 2008 Aug;154(Pt 8):2184-2194
references.pmid: 18667552
references.citation: Clin Rev Allergy Immunol. 2008 Dec;35(3):124-34
references.pmid: 18509765
references.citation: Curr Top Microbiol Immunol. 2009;337:61-91
references.pmid: 19812980
references.citation: Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15055-60
references.pmid: 23980177
references.citation: J Bacteriol. 2001 Sep;183(18):5395-401
references.pmid: 11514525
references.citation: Annu Rev Microbiol. 2011;65:189-213
references.pmid: 21639793
references.citation: Curr Opin Infect Dis. 2003 Apr;16(2):135-43
references.pmid: 12734446
references.citation: Mol Microbiol. 2006 Mar;59(5):1542-58
references.pmid: 16468994
references.citation: Mol Microbiol. 2009 May;72(3):612-32
references.pmid: 19426209
references.citation: Curr Opin Struct Biol. 2012 Jun;22(3):279-86
references.pmid: 22579413
references.citation: Infect Immun. 2004 Sep;72(9):4973-84
references.pmid: 15321989
references.citation: J Bacteriol. 2010 Sep;192(18):4627-42
references.pmid: 20622062
references.citation: Curr Opin Microbiol. 2009 Feb;12(1):67-73
references.pmid: 19157961
references.citation: Appl Environ Microbiol. 2010 Mar;76(5):1497-506
references.pmid: 20048056
references.citation: Int J Med Microbiol. 2006 Nov;296(7):449-66
references.pmid: 16949866
references.citation: Plant Dis. 2007 Apr;91(4):462
references.pmid: 30781201
references.citation: J Mol Biol. 2009 Sep 18;392(2):511-28
references.pmid: 19619561
references.citation: Int J Med Microbiol. 2006 Apr;296(2-3):73-81
references.pmid: 16476569
references.citation: J Mol Biol. 2006 Feb 3;355(5):1026-36
references.pmid: 16359708
references.citation: Microbiology (Reading). 2013 Sep;159(Pt 9):1931-1936
references.pmid: 23831999
references.citation: Mol Microbiol. 2005 Jun;56(6):1648-63
references.pmid: 15916613
references.citation: Mol Microbiol. 1994 Dec;14(5):999-1010
references.pmid: 7715460
references.citation: Mol Microbiol. 2001 Sep;41(6):1249-69
references.pmid: 11580832
references.citation: mBio. 2014 Mar 18;5(2):e00929-14
references.pmid: 24643865
references.citation: Mol Microbiol. 2002 Apr;44(1):107-18
references.pmid: 11967072
references.citation: PLoS Genet. 2008 Oct;4(10):e1000233
references.pmid: 18949034
references.citation: J Bacteriol. 2001 Nov;183(22):6676-83
references.pmid: 11673439
references.citation: J Bacteriol. 2008 Dec;190(24):7910-7
references.pmid: 18849421
references.citation: Mol Microbiol. 2001 Jun;40(5):1201-14
references.pmid: 11401723
references.citation: Mol Microbiol. 2008 Jun;68(5):1179-95
references.pmid: 18430141
references.citation: Mol Microbiol. 1999 Aug;33(4):721-31
references.pmid: 10447882
references.citation: Infect Immun. 2002 Mar;70(3):1657-63
references.pmid: 11854262
references.citation: PLoS Genet. 2014 Jun 19;10(6):e1004440
references.pmid: 24945892
references.citation: J Mol Biol. 2012 May 18;418(5):300-15
references.pmid: 22370561
references.citation: BMC Genomics. 2012 Oct 31;13:577
references.pmid: 23114024
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E707-15
references.pmid: 23382224
references.citation: Curr Top Microbiol Immunol. 2009;337:231-55
references.pmid: 19812985
references.citation: Genes Dev. 2011 Feb 15;25(4):397-408
references.pmid: 21325136
references.citation: Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):
references.pmid: 20980440
references.citation: Int J Med Microbiol. 2004 Apr;293(7-8):479-82
references.pmid: 15149021
references.citation: Nucleic Acids Res. 2006 Jul 05;34(11):3361-9
references.pmid: 16822857
references.citation: J Bacteriol. 2006 Aug;188(16):6026-33
references.pmid: 16885472
references.citation: Mol Genet Genomics. 2001 Apr;265(2):287-92
references.pmid: 11361339
references.citation: Mol Plant Microbe Interact. 1997 May;10(4):462-71
references.pmid: 9150595
references.citation: J Bacteriol. 2005 May;187(10):3496-501
references.pmid: 15866937
references.citation: J Bacteriol. 1995 Sep;177(17):5108-15
references.pmid: 7665490
references.citation: Mol Microbiol. 2010 Oct;78(1):158-72
references.pmid: 20735777
references.citation: Front Microbiol. 2013 Dec 16;4:375
references.pmid: 24379807
references.citation: Mol Plant Microbe Interact. 2003 Jan;16(1):53-64
references.pmid: 12580282
references.citation: Cell. 2005 Jan 14;120(1):49-58
references.pmid: 15652481
references.citation: Front Microbiol. 2011 Aug 22;2:167
references.pmid: 21991261
references.citation: Appl Environ Microbiol. 2009 Apr;75(7):1826-37
references.pmid: 19201975
references.citation: J Bacteriol. 2005 Jan;187(1):276-85
references.pmid: 15601712
references.citation: J Mol Biol. 2013 Oct 9;425(19):3662-77
references.pmid: 23274138
references.citation: Mol Microbiol. 2006 Dec;62(5):1469-83
references.pmid: 17074075
references.citation: PLoS One. 2013;8(2):e55492
references.pmid: 23383333
references.citation: Infect Immun. 2009 Jan;77(1):374-86
references.pmid: 18936184
references.citation: Mol Microbiol. 2009 Mar;71(5):1190-1204
references.pmid: 19170883
references.citation: Environ Microbiol. 2015 Jan;17(1):105-18
references.pmid: 24803210
references.citation: Clin Microbiol Rev. 2013 Oct;26(4):822-80
references.pmid: 24092857
references.citation: Nature. 2010 Sep 23;467(7314):426-9
references.pmid: 20864996
references.citation: Curr Opin Microbiol. 2008 Apr;11(2):128-33
references.pmid: 18396449
references.citation: Appl Environ Microbiol. 2003 Mar;69(3):1783-90
references.pmid: 12620870
references.citation: Infect Immun. 2005 Jun;73(6):3228-41
references.pmid: 15908347
references.citation: Nucleic Acids Res. 2014 Jun;42(11):6811-25
references.pmid: 24782516
references.citation: Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1562-6
references.pmid: 1311842
references.citation: FEMS Microbiol Lett. 2000 Jun 1;187(1):53-8
references.pmid: 10828400
references.citation: Clin Infect Dis. 2012 Sep;55(5):712-9
references.pmid: 22615330
references.citation: EMBO J. 1993 Jun;12(6):2467-76
references.pmid: 8508772
references.citation: J Bacteriol. 2014 Jan;196(2):357-66
references.pmid: 24187093
references.citation: J Bacteriol. 1992 May;174(9):3011-20
references.pmid: 1314807
references.citation: mBio. 2012 Nov 06;3(6):e00228-12
references.pmid: 23131828
references.citation: Mol Microbiol. 1996 Nov;22(4):715-27
references.pmid: 8951818
references.citation: Nat Protoc. 2014 Feb;9(2):263-93
references.pmid: 24407355
references.citation: FEMS Microbiol Lett. 2005 Feb 1;243(1):251-8
references.pmid: 15668026
references.citation: Plant Biol (Stuttg). 2007 Jan;9(1):4-20
references.pmid: 17058178
references.citation: Mol Plant Pathol. 2012 Aug;13(6):614-29
references.pmid: 22672649
references.citation: Nature. 1993 Aug 12;364(6438):639-42
references.pmid: 8350922
references.citation: Mol Microbiol. 1997 Apr;24(2):309-19
references.pmid: 9159518
references.citation: Biochem Biophys Res Commun. 2007 Jan 19;352(3):769-73
references.pmid: 17141182
references.citation: J Bacteriol. 1998 Jun;180(12):3187-96
references.pmid: 9620970
references.citation: Nature. 2007 Dec 6;450(7171):883-6
references.pmid: 18004304
references.citation: Mol Microbiol. 2003 Oct;50(2):445-61
references.pmid: 14617170
references.citation: BMC Microbiol. 2007 Jan 18;7:3
references.pmid: 17233907
references.citation: Mol Microbiol. 2012 Feb;83(3):599-611
references.pmid: 22229925
references.citation: Biochim Biophys Acta. 2013 Aug;1829(8):866-77
references.pmid: 23415794
references.citation: Curr Opin Microbiol. 2010 Feb;13(1):24-33
references.pmid: 20080057
references.citation: Cell. 2002 Aug 9;110(3):303-14
references.pmid: 12176318
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3129-34
references.pmid: 11854465
references.citation: Mol Microbiol. 2011 Jun;80(6):1561-80
references.pmid: 21488981
references.citation: Mol Microbiol. 2012 Apr;84(1):17-35
references.pmid: 22289118
references.citation: Mol Plant Microbe Interact. 2003 Dec;16(12):1106-17
references.pmid: 14651344
references.citation: J Bacteriol. 2003 Feb;185(3):1071-81
references.pmid: 12533483
references.citation: Mol Microbiol. 2003 Jun;48(6):1633-45
references.pmid: 12791144
references.citation: J Bacteriol. 1998 Jul;180(14):3629-34
references.pmid: 9658007
references.citation: Genes Dev. 2014 Jun 1;28(11):1239-51
references.pmid: 24888591
references.citation: Front Immunol. 2013 Dec 04;4:418
references.pmid: 24363655
references.citation: Appl Environ Microbiol. 2001 Mar;67(3):1400-3
references.pmid: 11229941
references.citation: PLoS Biol. 2007 Oct;5(10):2177-89
references.pmid: 17760501
references.citation: Travel Med Infect Dis. 2011 Nov;9(6):263-77
references.pmid: 22118951
references.citation: Nat Rev Microbiol. 2004 May;2(5):363-78
references.pmid: 15100690
references.citation: J Bacteriol. 1999 Jul;181(13):4133-6
references.pmid: 10383988
references.citation: Microbiol Mol Biol Rev. 2012 Mar;76(1):46-65
references.pmid: 22390972
references.citation: J Bacteriol. 2014 Jan;196(2):325-36
references.pmid: 24187088
references.citation: J Gen Microbiol. 1991 Oct;137(10):2273-9
references.pmid: 1663150
references.citation: Microbiology (Reading). 2013 Mar;159(Pt 3):475-492
references.pmid: 23288541
references.citation: J Bacteriol. 2003 Sep;185(17):5096-108
references.pmid: 12923082
references.citation: Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2593-7
references.pmid: 8637919
references.citation: J Exp Med. 1994 Feb 1;179(2):601-8
references.pmid: 8294870
references.citation: Infect Immun. 1983 Sep;41(3):1340-51
references.pmid: 6350186
references.citation: J Bacteriol. 2003 Aug;185(15):4450-60
references.pmid: 12867454
references.citation: J Bacteriol. 2006 Jun;188(11):3995-4006
references.pmid: 16707691
references.citation: J Biol Chem. 2005 Apr 15;280(15):14765-72
references.pmid: 15710615
references.citation: J Bacteriol. 2002 Aug;184(15):4089-95
references.pmid: 12107125
references.citation: J Bacteriol. 2003 Dec;185(24):7257-65
references.pmid: 14645287
references.citation: J Bacteriol. 2004 Jul;186(14):4457-65
references.pmid: 15231777
references.citation: EMBO J. 2001 Apr 17;20(8):1850-62
references.pmid: 11296219
references.citation: Nat Rev Microbiol. 2012 Feb 16;10(3):203-12
references.pmid: 22337166
references.citation: Mol Microbiol. 2014 Jun;92(5):1039-55
references.pmid: 24720786
references.citation: Infect Immun. 2006 Oct;74(10):5893-902
references.pmid: 16988269
references.citation: Infect Immun. 1998 Jul;66(7):3029-34
references.pmid: 9632562
references.citation: J Bacteriol. 2009 Nov;191(21):6654-64
references.pmid: 19717612
references.citation: J Bacteriol. 2006 Feb;188(4):1211-7
references.pmid: 16452401
references.citation: Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13120-5
references.pmid: 23878244
references.citation: Microb Pathog. 1986 Apr;1(2):139-48
references.pmid: 2907769
references.citation: RNA Biol. 2012 Jun;9(6):751-71
references.pmid: 22699555
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14073-8
references.pmid: 10570200
references.citation: Mol Microbiol. 2005 Aug;57(3):691-705
references.pmid: 16045614
references.citation: Mol Microbiol. 2007 Feb;63(3):859-71
references.pmid: 17181781
references.citation: J Bacteriol. 2010 Mar;192(6):1479-86
references.pmid: 20008065
references.citation: J Biol Chem. 2006 Oct 20;281(42):31832-42
references.pmid: 16923806
references.citation: Mol Microbiol. 1998 Oct;30(1):175-88
references.pmid: 9786194
references.citation: Clin Microbiol Rev. 1998 Jan;11(1):142-201
references.pmid: 9457432
references.citation: Mol Microbiol. 1998 Jul;29(1):219-34
references.pmid: 9701816
references.citation: Mol Microbiol. 2009 Apr;72(1):183-201
references.pmid: 19226327
references.citation: Mol Microbiol. 1998 Jun;28(5):917-29
references.pmid: 9663679
references.citation: Cell. 2004 Jul 9;118(1):69-82
references.pmid: 15242645
references.citation: Appl Environ Microbiol. 1995 May;61(5):1959-67
references.pmid: 7646031
references.citation: Curr Opin Microbiol. 2009 Feb;12(1):101-9
references.pmid: 19144561
references.citation: Mol Plant Microbe Interact. 2001 Apr;14(4):516-26
references.pmid: 11310739
references.citation: J Biol Chem. 2001 Jan 5;276(1):225-31
references.pmid: 11022030
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17162-7
references.pmid: 15569938
references.citation: Infect Immun. 2003 Jan;71(1):1-12
references.pmid: 12496143
references.citation: J Bacteriol. 2008 Apr;190(7):2527-36
references.pmid: 18223081
references.citation: Mol Genet Genomics. 2008 Apr;279(4):313-22
references.pmid: 18080141
references.citation: Mol Microbiol. 2003 May;48(3):657-70
references.pmid: 12694612
references.citation: Mol Microbiol. 2009 Feb;71(3):640-58
references.pmid: 19040633
references.citation: Mol Microbiol. 1990 Jun;4(6):1029-36
references.pmid: 2215211
references.citation: Cold Spring Harb Perspect Med. 2012 Nov 01;2(11):
references.pmid: 23125205
references.citation: J Bacteriol. 2010 Apr;192(7):2009-12
references.pmid: 20118252
references.citation: J Bacteriol. 2008 May;190(10):3670-80
references.pmid: 18359807
references.citation: Mol Microbiol. 2007 Jun;64(6):1466-85
references.pmid: 17555434
references.citation: Mol Microbiol. 2008 May;68(3):657-71
references.pmid: 18373522
references.citation: Environ Microbiol. 2010 Feb;12(2):524-40
references.pmid: 19919539
references.citation: J Clin Microbiol. 2004 Nov;42(11):5229-37
references.pmid: 15528719
references.citation: Mol Microbiol. 2002 Nov;46(4):1135-47
references.pmid: 12421317
references.citation: Front Microbiol. 2011 Oct 28;2:208
references.pmid: 22059087
references.citation: Trends Microbiol. 2011 May;19(5):217-24
references.pmid: 21333542
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12283-8
references.pmid: 11050248
references.citation: J Health Popul Nutr. 2013 Sep;31(3):299-307
references.pmid: 24288942
references.citation: Infect Immun. 1999 Nov;67(11):5690-8
references.pmid: 10531217
references.citation: Environ Microbiol. 2003 Dec;5(12):1294-308
references.pmid: 14641575
references.citation: Infect Immun. 2007 Apr;75(4):1946-53
references.pmid: 17261615
references.citation: FEMS Microbiol Lett. 2009 Aug;297(1):80-6
references.pmid: 19538511
references.citation: J Bacteriol. 2011 Sep;193(17):4516-22
references.pmid: 21705596
references.citation: RNA. 2005 Oct;11(10):1579-87
references.pmid: 16131593
references.citation: Mol Microbiol. 2001 Apr;40(1):245-56
references.pmid: 11298291
references.citation: Annu Rev Phytopathol. 2010;48:419-36
references.pmid: 19400638
references.citation: Future Microbiol. 2012 Jun;7(6):685-703
references.pmid: 22702524
references.citation: J Bacteriol. 1992 May;174(9):3021-9
references.pmid: 1314808
references.citation: Emerg Infect Dis. 2011 Jan;17(1):7-15
references.pmid: 21192848
references.citation: J Bacteriol. 2004 May;186(9):2724-34
references.pmid: 15090514
references.citation: Mol Microbiol. 1997 Dec;26(5):1023-34
references.pmid: 9426139
references.citation: Curr Top Microbiol Immunol. 2013;358:3-32
references.pmid: 23340801
references.citation: PLoS One. 2013;8(1):e54456
references.pmid: 23372726
references.citation: Clin Microbiol Rev. 2010 Apr;23(2):274-98
references.pmid: 20375353
references.citation: Mol Microbiol. 2000 May;36(4):940-54
references.pmid: 10844680
references.citation: Virulence. 2013 Nov 15;4(8):785-95
references.pmid: 23958954
references.citation: RNA Biol. 2013 Jan;10(1):96-110
references.pmid: 23093803
references.citation: Appl Environ Microbiol. 2007 Jan;73(2):650-4
references.pmid: 17098922
references.citation: Methods Mol Biol. 2014;1126:399-410
references.pmid: 24549678
references.citation: Mol Microbiol. 1998 Jan;27(2):323-36
references.pmid: 9484888
references.citation: J Bacteriol. 1999 Feb;181(3):899-906
references.pmid: 9922254
references.citation: Mol Microbiol. 2009 Aug;73(3):434-45
references.pmid: 19602144
references.citation: J Bacteriol. 2001 Oct;183(20):6017-27
references.pmid: 11567002
references.citation: J Bacteriol. 2011 May;193(9):2168-76
references.pmid: 21378194
references.citation: PLoS Pathog. 2014 Feb 27;10(2):e1003945
references.pmid: 24586158
references.citation: Microbiol Mol Biol Rev. 2013 Mar;77(1):1-52
references.pmid: 23471616
references.citation: J Bacteriol. 2005 Jul;187(14):4792-803
references.pmid: 15995194
references.citation: Infect Immun. 2000 Dec;68(12):6790-7
references.pmid: 11083797
references.citation: Curr Top Microbiol Immunol. 2013;376:103-15
references.pmid: 23918176
references.citation: Clin Microbiol Rev. 1997 Apr;10(2):257-76
references.pmid: 9105754
references.citation: Infect Immun. 2010 Nov;78(11):4674-82
references.pmid: 20713625
references.citation: Environ Microbiol. 2010 Dec;12(12):3196-212
references.pmid: 20626455
references.citation: PLoS Pathog. 2009 Mar;5(3):e1000354
references.pmid: 19325879
references.citation: Infect Immun. 1999 Aug;67(8):4099-105
references.pmid: 10417179
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17136-41
references.pmid: 16286659
references.citation: FEMS Microbiol Lett. 2007 Mar;268(1):81-7
references.pmid: 17263850
references.citation: PLoS One. 2008 Feb 13;3(2):e1603
references.pmid: 18270590
references.citation: Infect Immun. 2006 May;74(5):3012-5
references.pmid: 16622241
references.citation: J Bacteriol. 2007 Aug;189(15):5472-81
references.pmid: 17526692
references.citation: J Bacteriol. 2007 Aug;189(15):5574-81
references.pmid: 17545286
references.citation: Biochim Biophys Acta. 2013 Aug;1829(8):878-83
references.pmid: 23291566
references.citation: Curr Opin Biotechnol. 2000 Jun;11(3):290-7
references.pmid: 10851149
references.citation: Infect Immun. 2003 May;71(5):2839-58
references.pmid: 12704158
references.citation: Microbiol Mol Biol Rev. 2005 Mar;69(1):12-50
references.pmid: 15755952
references.citation: Mol Microbiol. 1999 Jan;31(2):665-77
references.pmid: 10027982
references.citation: Annu Rev Microbiol. 2008;62:35-51
references.pmid: 18454629
references.citation: Mol Microbiol. 1997 Jan;23(2):399-407
references.pmid: 9044273
references.citation: PLoS Pathog. 2010 Aug 26;6(8):e1001068
references.pmid: 20865170
references.citation: Mol Microbiol. 2000 Feb;35(4):949-60
references.pmid: 10692170
references.citation: Front Cell Infect Microbiol. 2012 Dec 17;2:158
references.pmid: 23251905
references.citation: Cell. 2003 Jul 25;114(2):157-9
references.pmid: 12887917
references.citation: Infect Immun. 1985 Nov;50(2):572-6
references.pmid: 3932213
references.citation: Mol Microbiol. 2007 Oct;66(2):341-56
references.pmid: 17850261
references.citation: J Biol Chem. 1975 May 25;250(10):3607-612
references.pmid: 805130
references.citation: J Biol Chem. 2009 Dec 11;284(50):34976-85
references.pmid: 19840935
references.citation: Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9851-6
references.pmid: 10449783
references.citation: Mol Plant Microbe Interact. 2005 Feb;18(2):169-78
references.pmid: 15720086
references.citation: Mol Microbiol. 2011 Oct;82(2):447-61
references.pmid: 21895793
references.citation: Mol Plant Microbe Interact. 2005 Jul;18(7):682-93
references.pmid: 16042014
references.citation: Genes Dev. 2006 Sep 15;20(18):2605-17
references.pmid: 16980588
references.citation: Transl Res. 2008 Dec;152(6):257-64
references.pmid: 19059160
references.citation: Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4365-70
references.pmid: 20150509
references.citation: Mol Microbiol. 2013 Feb;87(4):851-66
references.pmid: 23305111
references.citation: Mol Microbiol. 2005 May;56(4):858-70
references.pmid: 15853876
references.citation: Nat Rev Genet. 2004 Jan;5(1):34-42
references.pmid: 14708014
references.citation: J Biol Chem. 1997 Jul 11;272(28):17502-10
references.pmid: 9211896
references.citation: Mol Microbiol. 2002 Dec;46(5):1451-64
references.pmid: 12453229
references.citation: Gut Microbes. 2010 Jan;1(1):30-41
references.pmid: 21327114
references.citation: J Biol Chem. 1994 Dec 16;269(50):31567-72
references.pmid: 7989325
references.citation: Mol Microbiol. 2007 Jun;64(6):1605-20
references.pmid: 17555441
references.citation: RNA Biol. 2012 Apr;9(4):503-19
references.pmid: 22546937
references.citation: Microbiology (Reading). 2006 Nov;152(Pt 11):3411-3424
references.pmid: 17074910
references.citation: Adv Exp Med Biol. 1999;473:261-74
references.pmid: 10659367
references.citation: Mol Microbiol. 2013 Nov;90(3):457-71
references.pmid: 23957692
references.citation: Environ Microbiol. 2013 Feb;15(2):313-24
references.pmid: 22672726
references.citation: Mol Microbiol. 2011 Jun;80(6):1637-56
references.pmid: 21518393
references.citation: Nat Struct Mol Biol. 2007 Sep;14(9):807-13
references.pmid: 17704818
references.citation: PLoS One. 2012;7(2):e31765
references.pmid: 22363726
references.citation: Infect Immun. 1999 Jan;67(1):213-9
references.pmid: 9864218
references.citation: Methods Mol Biol. 2008;419:53-67
references.pmid: 18369975
references.citation: J Bacteriol. 2010 Jul;192(14):3584-96
references.pmid: 20472799
references.citation: Cell Microbiol. 2008 Jun;10(6):1209-20
references.pmid: 18363881
references.citation: Mol Plant Microbe Interact. 1996 Sep;9(7):565-73
references.pmid: 8810071
references.citation: Mol Microbiol. 2001 Jun;40(6):1289-99
references.pmid: 11442828
references.citation: Mol Microbiol. 2010 Jun;76(6):1427-43
references.pmid: 20398205
references.citation: Genes Dev. 2009 Feb 15;23(4):522-34
references.pmid: 19240136
references.citation: Mol Microbiol. 1998 Sep;29(6):1321-30
references.pmid: 9781871
references.citation: BMC Microbiol. 2006 Mar 10;6:27
references.pmid: 16529647
references.citation: Genes Dev. 2013 May 15;27(10):1132-45
references.pmid: 23666921
references.citation: Mol Microbiol. 2002 Jun;44(6):1599-610
references.pmid: 12067347
references.citation: J Bacteriol. 2002 Feb;184(4):1046-56
references.pmid: 11807065
references.citation: Nature. 2000 Oct 12;407(6805):762-4
references.pmid: 11048725
references.citation: J Vis Exp. 2010 Jul 02;(41):
references.pmid: 20644507
references.citation: Mol Microbiol. 2009 May;72(3):741-62
references.pmid: 19400772
references.citation: J Bacteriol. 2005 Dec;187(23):8026-38
references.pmid: 16291676
references.citation: Environ Microbiol. 2000 Apr;2(2):203-15
references.pmid: 11220306
references.citation: PLoS Genet. 2009 Jan;5(1):e1000344
references.pmid: 19165319
references.citation: Mol Microbiol. 2000 Jul;37(2):300-15
references.pmid: 10931326
references.citation: Microbiol Rev. 1996 Sep;60(3):539-74
references.pmid: 8840786
references.citation: Structure. 2013 Sep 3;21(9):1659-71
references.pmid: 23954502
references.citation: RNA Biol. 2012 Apr;9(4):379-91
references.pmid: 22336760
references.citation: J Bacteriol. 2011 Nov;193(22):6162-70
references.pmid: 21908661
references.citation: J Bacteriol. 1993 Sep;175(17):5740-1
references.pmid: 8366066
references.citation: J Bacteriol. 1994 Dec;176(24):7468-75
references.pmid: 8002569
references.citation: Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17480-5
references.pmid: 21969563
references.citation: Dev Cell. 2004 Nov;7(5):745-54
references.pmid: 15525535
references.citation: Am J Respir Crit Care Med. 2005 Jun 1;171(11):1209-23
references.pmid: 15695491
references.citation: J Bacteriol. 1999 Aug;181(16):4879-89
references.pmid: 10438758
references.citation: Infect Immun. 1980 Sep;29(3):1146-51
references.pmid: 6107276
references.citation: PLoS One. 2014 Feb 24;9(2):e89653
references.pmid: 24586939
references.citation: Mol Plant Microbe Interact. 2006 Mar;19(3):257-69
references.pmid: 16570656
references.citation: Microbiology (Reading). 2010 Aug;156(Pt 8):2470-2483
references.pmid: 20466769
references.citation: Mol Microbiol. 2013 Mar;87(5):1045-60
references.pmid: 23289537
references.citation: Mol Microbiol. 2009 May;72(4):995-1010
references.pmid: 19400807
references.citation: Trends Microbiol. 2009 Aug;17(8):361-70
references.pmid: 19660954
references.citation: Trends Microbiol. 2005 Oct;13(10):497-503
references.pmid: 16140013
references.citation: PLoS One. 2012;7(4):e36043
references.pmid: 22558320
references.citation: J Bacteriol. 2002 Sep;184(18):5130-40
references.pmid: 12193630
references.citation: J Bacteriol. 2008 Mar;190(6):2023-30
references.pmid: 18178737
references.citation: Proc Natl Acad Sci U S A. 1992 Jan 15;89(2):718-22
references.pmid: 1731345
references.citation: FEMS Microbiol Lett. 1994 Feb 15;116(2):155-60
references.pmid: 8150259
references.citation: Crit Rev Microbiol. 2012 Nov;38(4):276-99
references.pmid: 22435753
references.citation: Microbiology (Reading). 2008 Jan;154(Pt 1):16-29
references.pmid: 18174122
references.citation: FEMS Microbiol Rev. 2010 Mar;34(2):107-33
references.pmid: 19925633
references.citation: J Bacteriol. 2006 Jul;188(13):4715-26
references.pmid: 16788181
references.citation: Annu Rev Microbiol. 2012;66:453-72
references.pmid: 22746332
references.citation: Mol Microbiol. 2011 Aug;81(3):689-704
references.pmid: 21696456
references.citation: J Bacteriol. 2010 Jul;192(14):3597-607
references.pmid: 20453093
references.citation: FEMS Microbiol Rev. 2010 Sep;34(5):866-82
references.pmid: 20662934
references.citation: Infect Immun. 1981 Jul;33(1):142-8
references.pmid: 6790439
references.citation: J Exp Med. 2002 May 6;195(9):1155-66
references.pmid: 11994420
references.citation: Phytopathology. 2012 Jun;102(6):575-87
references.pmid: 22568815
references.citation: mBio. 2012 Jun 12;3(3):
references.pmid: 22691391
references.citation: J Bacteriol. 1995 May;177(10):2663-72
references.pmid: 7751274
references.citation: J Bacteriol. 2014 Feb;196(3):681-92
references.pmid: 24272784
references.citation: Sci Prog. 2007;90(Pt 2-3):103-27
references.pmid: 17725229
references.citation: J Bacteriol. 2008 May;190(9):3411-6
references.pmid: 18310331
references.citation: J Bacteriol. 2007 Mar;189(5):1963-73
references.pmid: 17158661
references.citation: Mol Microbiol. 2007 Mar;63(5):1508-23
references.pmid: 17302824
references.citation: Mol Microbiol. 1997 May;24(4):747-56
references.pmid: 9194702
references.citation: EMBO J. 2013 Oct 30;32(21):2872-83
references.pmid: 24056837
references.citation: J Bacteriol. 2002 Aug;184(15):4148-60
references.pmid: 12107132
references.citation: Infect Immun. 2004 Jun;72(6):3284-93
references.pmid: 15155631
references.citation: PLoS One. 2012;7(2):e31348
references.pmid: 22363626
references.citation: Infect Immun. 2008 Feb;76(2):632-8
references.pmid: 18025099
references.citation: J Bacteriol. 2008 Jun;190(12):4233-41
references.pmid: 18424519
references.citation: Mol Microbiol. 2014 Jun;92(5):945-58
references.pmid: 24708042
references.citation: EMBO J. 1993 Jun;12(6):2477-82
references.pmid: 8508773
references.citation: Mol Microbiol. 2006 Mar;59(6):1779-89
references.pmid: 16553883
references.citation: Cell Microbiol. 2011 Nov;13(11):1639-47
references.pmid: 21740501
references.citation: Nucleic Acids Res. 2007;35(22):7651-64
references.pmid: 17982174
references.citation: PLoS Pathog. 2008 Jun 20;4(6):e1000093
references.pmid: 18566662
references.citation: Cell Microbiol. 2007 Dec;9(12):2903-20
references.pmid: 17614967
references.citation: Curr Opin Microbiol. 2009 Feb;12(1):117-24
references.pmid: 19157959
references.citation: Front Biosci (Landmark Ed). 2009 Jan 01;14(11):4103-12
references.pmid: 19273337
references.citation: Int J Med Microbiol. 2001 Nov;291(5):353-60
references.pmid: 11727819
references.citation: Mol Plant Microbe Interact. 2008 Apr;21(4):411-23
references.pmid: 18321187
references.citation: Res Microbiol. 2011 Jun;162(5):488-98
references.pmid: 21527339
references.citation: Trends Microbiol. 1998 Jul;6(7):253-5
references.pmid: 9717210
references.citation: Infect Immun. 1994 Oct;62(10):4641-5
references.pmid: 7927733
references.citation: Nature. 2011 Jul 06;475(7354):118-21
references.pmid: 21734708
references.citation: Gene. 1997 Jun 11;192(1):51-9
references.pmid: 9224874
references.citation: FEMS Microbiol Lett. 2009 Mar;292(1):50-6
references.pmid: 19191877
references.citation: Genes Dev. 2009 Jan 15;23(2):249-59
references.pmid: 19171785
references.citation: Mol Microbiol. 2000 Jan;35(1):139-49
references.pmid: 10632884
references.citation: J Hosp Infect. 2007 Apr;65(4):374-5; author reply 375-6
references.pmid: 17275952
references.citation: Nat Rev Microbiol. 2014 Feb;12(2):137-48
references.pmid: 24384601
references.citation: Nucleic Acids Res. 2014 Apr;42(8):5332-46
references.pmid: 24561806
references.citation: Mol Microbiol. 2005 Nov;58(4):1186-202
references.pmid: 16262799
references.citation: Arch Microbiol. 2000 Mar;173(3):170-7
references.pmid: 10763748
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):171-6
references.pmid: 16373506
references.citation: J Bacteriol. 2000 Mar;182(5):1215-25
references.pmid: 10671440
references.citation: Infect Immun. 2006 Jan;74(1):331-9
references.pmid: 16368988
references.citation: J Bacteriol. 2005 Nov;187(21):7317-24
references.pmid: 16237014
references.citation: Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9930-5
references.pmid: 15985546
references.citation: Curr Opin Microbiol. 2013 Feb;16(1):100-7
references.pmid: 23403118
references.citation: Trends Microbiol. 2008 Jun;16(6):284-90
references.pmid: 18467098
references.citation: Cell Microbiol. 2009 Feb;11(2):351-62
references.pmid: 19016783
references.citation: RNA Biol. 2014;11(5):580-93
references.pmid: 24786463
references.citation: PLoS One. 2008 Jul 30;3(7):e2826
references.pmid: 18665275
references.citation: Annu Rev Microbiol. 2009;63:27-44
references.pmid: 19385727
references.citation: Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1165-83
references.pmid: 17360277