title: Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions.
abstract: OBJECTIVE
  We conducted a neuroimaging analysis to understand the neuroanatomical correlates of gray matter loss in a group of mild cognitive impairment and early Alzheimer's disease patients who developed delusions.
  
  
  METHODS
  With data collected as part of the Alzheimer's Disease Neuroimaging Initiative, we conducted voxel-based morphometry to determine areas of gray matter change in the same Alzheimer's Disease Neuroimaging Initiative participants, before and after they developed delusions.
  
  
  RESULTS
  We identified 14 voxel clusters with significant gray matter decrease in patient scans post-delusional onset, correcting for multiple comparisons (false discovery rate, p < 0.05). Major areas of difference included the right and left insulae, left precuneus, the right and left cerebellar culmen, the left superior temporal gyrus, the right posterior cingulate, the right thalamus, and the left parahippocampal gyrus.
  
  
  CONCLUSIONS
  Although contrary to our initial predictions of enhanced right frontal atrophy, our preliminary work identifies several neuroanatomical areas, including the cerebellum and left posterior hemisphere, which may be involved in delusional development in these patients.
authors.affiliation: Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.|Faculty of Medicine, Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
authors.forename: Corinne E
authors.initials: CE
authors.lastname: Fischer
authors.affiliation: Institute of Medical Science, University of Toronto, Toronto, ON, Canada.|Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Windsor Kwan-Chun
authors.initials: WK
authors.lastname: Ting
authors.affiliation: Department of Clinical Health Psychology, College of Medicine, Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
authors.forename: Colleen P
authors.initials: CP
authors.lastname: Millikin
authors.affiliation: Hotchkiss Brain Institute, Calgary, AB, Canada.
authors.forename: Zahinoor
authors.initials: Z
authors.lastname: Ismail
authors.affiliation: Institute of Medical Science, University of Toronto, Toronto, ON, Canada.|Keenan Research Centre for Biomedical Science, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.|Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.|Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.|Division of Neurosurgery, St. Michael's Hospital, Toronto, ON, Canada.
authors.forename: Tom A
authors.initials: TA
authors.lastname: Schweizer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D001284:Atrophy; D001931:Brain Mapping / Q000379:methods; D060825:Cognitive Dysfunction / Q000473:pathology* / Q000523:psychology; D003702:Delusions / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D059906:Neuroimaging / Q000379:methods
keywords: Alzheimer's disease; delusions; psychosis; voxel-based morphometry
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