title: Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study.
abstract: It is noteworthy that some children with benign childhood epilepsy with centrotemporal spikes (BECTS) show attention problems despite their favorable seizure outcome. Resting-state functional magnetic resonance imaging (fMRI) is a method widely used to detect brain network alterations in neuropsychiatric diseases. We used resting-state functional magnetic resonance imaging (fMRI) to investigate specific brain networks related to attention deficit in children with BECTS. Resting-state fMRI was performed in patients with BECTS with ADHD (n=15) and those with BECTS without ADHD (n=15) and in healthy controls (n=15). Unbiased seed-based whole-brain functional connectivity analysis was used to study the connectivity pattern of three resting-state networks, including the ventral attention network (VAN) and the dorsal attention network (DAN) and the default mode network (DMN). Patients with BECTS with ADHD displayed decreased functional connectivity in the DAN compared with other two groups, while patients with BECTS without ADHD showed increased functional connectivity in the DAN. Moreover, we found increased functional connectivity in the VAN and in the DMN in patients with BECTS with or without ADHD when comparing with controls. These results showed that the newly-diagnosed children with BECTS displayed brain activity alterations in the ventral and dorsal attention networks. The difference in the extent of impairment in the dorsal attention network of patients with BECTS with ADHD and patients with BECTS without ADHD may lead to improved understanding of the underlying neuropathophysiology and treatment of BECTS with ADHD and BECTS without ADHD.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Fenglai
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: An
authors.affiliation: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Du
authors.initials: D
authors.lastname: Lei
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Tianhua
authors.initials: T
authors.lastname: Yang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jiechuan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Sihan
authors.initials: S
authors.lastname: Chen
authors.affiliation: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.affiliation: Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: zhoudong66@yahoo.de.
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Electronic address: qiyonggong@hmrrc.org.cn.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
mesh_terms: D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002648:Child; D002675:Child, Preschool; D019305:Epilepsy, Rolandic / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000378:metabolism / Q000503:physiopathology*; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D012146:Rest / Q000502:physiology
keywords: Attention deficit and hyperactivity disorder; Benign childhood epilepsy with centrotemporal spikes; Functional connectivity; fMRI