title: Multivariate fMRI and Eye Tracking Reveal Differential Effects of Visual Interference on Recognition Memory Judgments for Objects and Scenes.
abstract: Recent work has demonstrated that the perirhinal cortex (PRC) supports conjunctive object representations that aid object recognition memory following visual object interference. It is unclear, however, how these representations interact with other brain regions implicated in mnemonic retrieval and how congruent and incongruent interference influences the processing of targets and foils during object recognition. To address this, multivariate partial least squares was applied to fMRI data acquired during an interference match-to-sample task, in which participants made object or scene recognition judgments after object or scene interference. This revealed a pattern of activity sensitive to object recognition following congruent (i.e., object) interference that included PRC, prefrontal, and parietal regions. Moreover, functional connectivity analysis revealed a common pattern of PRC connectivity across interference and recognition conditions. Examination of eye movements during the same task in a separate study revealed that participants gazed more at targets than foils during correct object recognition decisions, regardless of interference congruency. By contrast, participants viewed foils more than targets for incorrect object memory judgments, but only after congruent interference. Our findings suggest that congruent interference makes object foils appear familiar and that a network of regions, including PRC, is recruited to overcome the effects of interference.
authors.affiliation: University of Toronto, Ontario, Canada.
authors.forename: Edward B
authors.initials: EB
authors.lastname: O'Neil
authors.affiliation: University of Toronto, Ontario, Canada.
authors.forename: Hilary C
authors.initials: HC
authors.lastname: Watson
authors.affiliation: University of Toronto, Ontario, Canada.
authors.forename: Sonya
authors.initials: S
authors.lastname: Dhillon
authors.affiliation: University of Toronto, Ontario, Canada.|Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Lobaugh
authors.affiliation: University of Toronto, Ontario, Canada.|Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada.
authors.forename: Andy C H
authors.initials: AC
authors.lastname: Lee
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D053483:Eye Movement Measurements; D005133:Eye Movements; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology*; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D055815:Young Adult