title: Adoptive cell transfer as personalized immunotherapy for human cancer.
abstract: Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to each cancer. These results have expanded the reach of ACT to the treatment of common epithelial cancers. In addition, the ability to genetically engineer lymphocytes to express conventional T cell receptors or chimeric antigen receptors has further extended the successful application of ACT for cancer treatment.
authors.affiliation: Surgery Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 9000 Rockville Pike, CRC Building, Room 3W-3940, Bethesda, MD 20892, USA. sar@nih.gov restifo@nih.gov.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rosenberg
authors.affiliation: Surgery Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 9000 Rockville Pike, CRC Building, Room 3W-3940, Bethesda, MD 20892, USA. sar@nih.gov restifo@nih.gov.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: Restifo
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology; D005818:Genetic Engineering; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D008212:Lymphocyte Depletion; D008545:Melanoma / Q000235:genetics / Q000556:secondary / Q000628:therapy; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D013601:T-Lymphocytes / Q000637:transplantation
chemical_list: D000951:Antigens, Neoplasm
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