title: Hepatocyte nuclear factor-1β: A regulator of kidney development and cystogenesis.
abstract: The understanding of the genomics of the renal tissue has gathered a considerable interest and is making rapid progress. The molecular mechanisms as well as the precise function of the associated molecular components toward renal pathophysiology have recently been realized. For the cystic kidney disease, the regulation of gene expression affecting epithelial cells proliferation, apoptosis as well as process of differentiation/de-differentiation represent key molecular targets. For the cystic disorders, molecular targets have been identified, which besides lending heterogeneity to cysts may also provide tools to unravel their functional importance to understand the renal tissue homeostasis. This review focuses on providing comprehensive information about the transcriptional regulatory role of hepatocyte nuclear factor-1β, a homeoprotein, as well as its interacting partners in renal tissue development and pathophysiology.
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh, India.
authors.forename: V
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Panjab University, Chandigarh, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Singla
authors.affiliation: Department of Nephrology, PGIMER, Chandigarh, India.
authors.forename: V
authors.initials: V
authors.lastname: Jha
authors.affiliation: Centre for Systems Biology and Bioinformatics, Under University Institute of Emerging Areas in Science and Technology, Panjab University, Chandigarh, India.
authors.forename: V
authors.initials: V
authors.lastname: Puri
authors.affiliation: Biotechnology Branch, University Institute of Engineering and Technology, Chandigarh, India ; Centre for Stem Cell and Issue Engineering, University Institute of Emerging Areas in Science and Technology, Panjab University, Chandigarh, India.
authors.forename: S
authors.initials: S
authors.lastname: Puri
keywords: Kidney development; hepatocyte nuclear factor-1β; renal cystogenesis; transcription factor
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