title: No evidence of transfusion transmission of Adenovirus and Epstein-Barr virus infections in paediatric recipients post-bone marrow transplant.
abstract: Adenovirus and Epstein-Barr virus can cause significant morbidity and mortality in paediatric patients post-bone marrow transplant. The source of infection is thought to be either reactivation of latent viruses or primary infection. We have investigated whether transfusion of blood components from viraemic donors could provide a route of primary infection in these patients and sought the prevalence of viraemia in the blood donor population from England. In 32 linked donor/recipient samples and 300 unselected blood donors, we found no evidence to suggest that these infections in paediatric bone marrow transplant recipients had been acquired from transfused blood components.
authors.affiliation: R & D Transfusion Microbiology, NHS Blood and Transplant, London, UK.|Blood Borne Virus Unit, Public Health England, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Patel
authors.affiliation: R & D Transfusion Microbiology, NHS Blood and Transplant, London, UK.|Blood Borne Virus Unit, Public Health England, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Tuke
authors.affiliation: R & D Transfusion Microbiology, NHS Blood and Transplant, London, UK.|Blood Borne Virus Unit, Public Health England, London, UK.
authors.forename: K
authors.initials: K
authors.lastname: Tettmar
authors.affiliation: Camelia Botnar Laboratory, Great Ormond Street Hospital, London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Cloutman-Green
authors.affiliation: Camelia Botnar Laboratory, Great Ormond Street Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hartley
authors.affiliation: Infectious Diseases and Microbiology, Institute of Child Health, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Klein
authors.affiliation: Bone Marrow Transplant Unit, Great Ormond Street Hospital, London, UK.
authors.forename: P
authors.initials: P
authors.lastname: Veys
authors.affiliation: R & D Transfusion Microbiology, NHS Blood and Transplant, London, UK.|Blood Borne Virus Unit, Public Health England, London, UK.
authors.forename: R S
authors.initials: RS
authors.lastname: Tedder
mesh_terms: D000256:Adenoviridae / Q000235:genetics* / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000635:transmission / Q000821:virology; D016913:Blood Component Transfusion; D001782:Blood Donors; D016026:Bone Marrow Transplantation; D004279:DNA, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D020031:Epstein-Barr Virus Infections / Q000635:transmission / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D004279:DNA, Viral
keywords: blood safety; bone marrow; transfusion - paediatric; transfusion - transmissible infections; transplantation