title: Preoperative embolization of intracranial meningiomas using n-butyl cyanoacrylate.
abstract: BACKGROUND
  Preoperative embolization for intracranial meningioma has been controversial for several decades. This study retrospectively reviewed our experience using n-butyl cyanoacrylate (n-BCA) to identify the factors for effective devascularization and procedure-related complications.
  
  
  METHODS
  Fifty-seven patients who underwent preoperative embolization with n-BCA were analyzed to collect the following data: age, sex, tumor size, location, pathology, and presence or absence of pial arterial supply. The predictive factors for total devascularization and complications were examined using univariate and multivariate analyses.
  
  
  RESULTS
  Injected n-BCA penetrated into the tumor vessels in 51 cases (89%) but resulted in feeder occlusion in 6 (11%). Angiographic total devascularization was achieved in 29 cases (51%) and partial devascularization in 28 (49%). Small size, superficial location, and absence of pial supply were independent factors for total devascularization. No major complication was encountered, but asymptomatic or transient adverse events occurred in nine patients and were significantly associated with elderly patients and large tumors.
  
  
  CONCLUSIONS
  Preoperative embolization for intracranial meningiomas using n-BCA can attain effective devascularization without major complications. The effect of preoperative embolization on surgical resection or patient outcome is still unknown.
authors.affiliation: Department of Neurosurgery, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan, masa.a6221@gmail.com.
authors.forename: Masanori
authors.initials: M
authors.lastname: Aihara
authors.forename: Isao
authors.initials: I
authors.lastname: Naito
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiroya
authors.initials: H
authors.lastname: Fujimaki
authors.forename: Ken
authors.initials: K
authors.lastname: Asakura
authors.forename: Naoko
authors.initials: N
authors.lastname: Miyamoto
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Yoshimoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004621:Embolization, Therapeutic / Q000379:methods*; D004659:Enbucrilate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000628:therapy*; D008579:Meningioma / Q000628:therapy*; D008875:Middle Aged; D011300:Preoperative Care; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D004659:Enbucrilate
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