title: Modifications of natural peptides for nanoparticle and drug design.
abstract: Natural products serve as an important source of novel compounds for drug development. Recently, peptides have emerged as a new class of therapeutic agents due to their versatility and specificity for biological targets. Yet, their effective application often requires use of a nanoparticle delivery system. In this chapter, we review the role of natural peptides in the design and creation of nanomedicines, with a particular focus on cell-penetrating peptides, antimicrobial peptides, and peptide toxins. The use of natural peptides in conjunction with nanoparticle delivery systems holds great promise for the development of new therapeutic formulations as well as novel platforms for the delivery of various cargoes.
authors.affiliation: Consortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Jallouk
authors.affiliation: Consortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Rohun U
authors.initials: RU
authors.lastname: Palekar
authors.affiliation: Consortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Hua
authors.initials: H
authors.lastname: Pan
authors.affiliation: Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA.
authors.forename: Paul H
authors.initials: PH
authors.lastname: Schlesinger
authors.affiliation: Consortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA. Electronic address: wicklines@aol.com.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Wickline
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D014118:Toxins, Biological / Q000737:chemistry* / Q000633:toxicity
chemical_list: D001688:Biological Products; D057846:Cell-Penetrating Peptides; D014118:Toxins, Biological
keywords: Antimicrobial peptide; Cell-penetrating peptide; Drug delivery; Nanoparticle; Natural peptide; Peptide toxin
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