title: [Few drugs dominate among clinically important interactions. Swedish register study lists problem drugs].
abstract: In a recent Swedish register study, a limited number of specific drugs explained a large part of clinically relevant, potential drug-drug interactions (DDI), as defined and detected by the DDI database SFINX. Regarding interactions that should be avoided according to the definition in the database (class D), 15 drug combinations accounted for as much as 80 % of the prevalence in the Swedish population. Ten specific drugs were involved in 94 % of all detected class D interactions. About half of the clinically relevant interactions detected during the four-month study period were associated with an increased risk of adverse drug reactions, whereas the other half has a potential to cause therapeutic failure. An increased awareness among prescribers of these interacting drugs could contribute to safer and more effective drug use.
authors.affiliation: Karolinska universitetssjukhuset - Klinisk farmakologi Stockholm, Sweden Karolinska universitetssjukhuset - Klinisk farmakologi Stockholm, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Holm
authors.affiliation: Karolinska Institutet - Institutionen för laboratoriemedicin Stockholm, Sweden Labtech - Klinisk farmakologi Huddinge, Sweden.
authors.forename: Birgit
authors.initials: B
authors.lastname: Eiermann
authors.affiliation: Klinisk Farmakologi - Karolinska Universitetssjukhuset Huddinge Stockholm, Sweden - .
authors.forename: Erik
authors.initials: E
authors.lastname: Eliasson
authors.affiliation: Södersjukhuset - Sektionen för endokrinologi och diabetes Stockholm, Sweden Södersjukhuset - Sektionen för endokrinologi och diabetes Stockholm, Sweden.
authors.forename: Buster
authors.initials: B
authors.lastname: Mannheimer
mesh_terms: D000367:Age Factors; D016208:Databases, Factual; D020000:Decision Support Systems, Clinical; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012042:Registries; D012737:Sex Factors; D013548:Sweden