title: The use of cisplatin-loaded mucoadhesive nanofibers for local chemotherapy of cervical cancers in mice.
abstract: Polymer-based local drug delivery system may be suitable for the treatment of cervix cancer. A pilot study was carried out to examine the efficacy of cisplatin-loaded poly(ethylene oxide)/polylactide composite electrospun nanofibers as a local chemotherapy system against cervical cancer in mice via vaginal implantation. The nanofibers were proven to have good mucoadhesive property by in vitro mucoadhesion test and in vivo vaginal retention evaluation. An orthotopic cervical/vaginal cancer model was established by injecting murine cervical cancer U14 cells into the vaginal submucosa nearby the cervix. By inserting the nanofibers mat into the vagina of mice, the cisplatin released from the fiber-mat showed a much more accumulation in the vagina/cervix region than in the peripheral organs such as kidneys, liver, or blood, in contrary to the case of intravenous (i.v) injection. The in vivo trials showed that a better balance between anti-tumor efficacy and systemic safety was achieved in nanofibers group than that in i.v injection group at the equal drug dose. Therefore, electrospun nanofibers present a promising approach to the local drug delivery via vagina against cervical cancer.
authors.affiliation: The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zong
authors.affiliation: China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.affiliation: The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Xuzhou Central Hospital Affiliated to Southeast University, Xuzhou 221009, China.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wu
authors.affiliation: China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Li
authors.affiliation: The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Wenhai
authors.initials: W
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Yubin
authors.initials: Y
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Xie
authors.affiliation: The First Hospital of Jilin University, Changchun 130021, China. Electronic address: yying119@126.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yue
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: liushi@ciac.ac.cn.
authors.forename: Shi
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers; D005260:Female; D051379:Mice; D009077:Mucins / Q000737:chemistry; D057139:Nanofibers; D050997:Nanomedicine; D010865:Pilot Projects; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014018:Tissue Distribution; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009077:Mucins; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide); D002945:Cisplatin
keywords: Cervical cancer; Cisplatin; Local chemotherapy; Nanofibers; Vaginal delivery