title: Lung disease in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) affects approximately 1% of the US population frequently has extra-articular manifestations. Most compartments of the lung are susceptible to disease. Interstitial lung disease (ILD) and airways disease are the most common forms of RA-related lung disease. RA-ILD carries the worst prognosis and most often manifests in a histologic pattern of usual interstitial pneumonia or nonspecific interstitial pneumonia. There have been no large, well-controlled prospective studies investigating therapies for RA-ILD. Treatment usually entails immunomodulatory agents. Further studies are needed to better understand pathogenic mechanisms of disease that lead to lung involvement in these patients.
authors.affiliation: Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.
authors.forename: Zulma X
authors.initials: ZX
authors.lastname: Yunt
authors.affiliation: Autoimmune Lung Center, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address: solomonj@njhealth.org.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Solomon
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
keywords: Bronchiolitis; Drug-induced lung disease; Extra-articular disease; Interstitial lung disease; Interstitial pneumonia; Pleural effusion; Pulmonary; Rheumatoid arthritis
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