title: Survival analysis and other clinical outcomes of immediate implant placement in sites with periapical lesions: systematic review.
abstract: OBJECTIVE
  Immediate implantation has become one of the therapeutic options for replacement of a hopeless tooth. In the case of a tooth with a periapical lesion, this approach remains controversial. The aims of this article were to systematically review the evidence on immediate implants in sites with periapical lesions with reference to: (1) survival rates, (2) changes in crestal bone levels and marginal tissues, (3) complication rates, and (4) comparison of clinical outcomes with other implant treatments.
  
  
  METHODS
  An electronic search was conducted in MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE for articles published between January 1990 and August 2013. Publications were screened, and data extraction and quality assessment were performed. Implant survival rates were calculated using predicted Kaplan-Meier survival analysis. Crestal bone level changes, soft tissue outcomes, complications, and procedure characteristics were analyzed descriptively.
  
  
  RESULTS
  Initially, 301 articles were identified. Three prospective controlled trials of immediate implant placement in sites with periapical lesions with a follow-up period of at least 1 year were selected for the survival analysis. The predicted cumulative 5-year survival rate of immediate implants in sites with periapical lesions was 96.23%. Bone and gingival level changes were comparable to those of implants placed in sites without periapical pathology. The complication rates, reported in only one study, were 15.4% (2/13) in sites with periapical lesions and 6.7% (1/15) in healthy sites.
  
  
  CONCLUSIONS
  Limited evidence suggests that immediate implant placement in sites with periapical lesions leads to clinical outcomes comparable to those of immediate implants in healthy sites. Additional prospective controlled trials with large sample sizes and long-term follow-up are needed to further investigate these results.
authors.forename: Chun-Teh
authors.initials: CT
authors.lastname: Lee
authors.forename: Sung-Kiang
authors.initials: SK
authors.lastname: Chuang
authors.forename: Janet
authors.initials: J
authors.lastname: Stoupel
mesh_terms: D003758:Dental Implantation, Endosseous / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D010485:Periapical Periodontitis; D011446:Prospective Studies; D020390:Tooth Socket / Q000601:surgery