title: Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets.
abstract: This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-Infrared (FT-IR), X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) techniques were used to characterize Cop-CM, in addition to characterization of its powder and ODT dosage form. The effect of particle size distribution of Cop-CM was investigated and found to have no significant influence on the overall tablet physical properties. The compressibility parameter (a) for Cop-CM was calculated from a Kawakita plot and found to be higher (0.661) than that of mannitol (0.576) due to the presence of the highly compressible chitin (0.818). Montelukast sodium and domperidone ODTs produced, using Cop-CM, displayed excellent physicochemical properties. The exceptional binding, fast wetting and superdisintegration properties of Cop-CM, in comparison with commercially available co-processed ODT excipients, results in a unique multifunctional base which can successfully be used in the formulation of oro-dispersible and fast immediate release tablets.
authors.affiliation: The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan. nidalda@hotmail.com.|Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime Kent ME44TB, UK. nidalda@hotmail.com.
authors.forename: Nidal
authors.initials: N
authors.lastname: Daraghmeh
authors.affiliation: Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime Kent ME44TB, UK. b.z.chowdhry@greenwich.ac.uk.
authors.forename: Babur Z
authors.initials: BZ
authors.lastname: Chowdhry
authors.affiliation: Faculty of Engineering & Science, University of Greenwich, Medway Campus, Chatham Maritime Kent ME44TB, UK. s.a.leharne@greenwich.ac.uk.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Leharne
authors.affiliation: The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan. momari@jpm.com.jo.
authors.forename: Mahmoud M H
authors.initials: MM
authors.lastname: Al Omari
authors.affiliation: The Jordanian Pharmaceutical Manufacturing Co., PO Box 94, Naor 11710, Jordan. jpm@go.com.jo.
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Badwan
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000737:chemistry; D000284:Administration, Oral; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000737:chemistry; D000932:Antiemetics / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002686:Chitin / Q000737:chemistry* / Q000648:ultrastructure; D003521:Cyclopropanes; D004294:Domperidone / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D008353:Mannitol / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D033362:Powder Diffraction; D011804:Quinolines / Q000008:administration & dosage / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013440:Sulfides; D013607:Tablets; D014867:Water / Q000032:analysis
chemical_list: D000085:Acetates; D018927:Anti-Asthmatic Agents; D000932:Antiemetics; D003521:Cyclopropanes; D005079:Excipients; D011804:Quinolines; D013440:Sulfides; D013607:Tablets; D014867:Water; D002686:Chitin; D008353:Mannitol; D004294:Domperidone; C093875:montelukast
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