title: Take my breath away: necrosis in kidney transplants kills the lungs!
abstract: Necrosis is not only a regulated process, it is an interconnected molecular network allowing different genetically encoded forms that are more or less immunogenic. Zhao et al. elegantly illustrate this concept, underscore the need for combination therapy to successfully interfere with regulated necrosis, and identify the role of regulated necrosis in the pathophysiology of remote lung injury.
authors.affiliation: 1] Inflammation Research Center, VIB, Ghent, Belgium [2] Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Vanden Berghe
authors.affiliation: Clinic for Nephrology and Hypertension, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Linkermann
mesh_terms: D055371:Acute Lung Injury / Q000473:pathology* / Q000517:prevention & control*; D000818:Animals; D053938:DNA Fragmentation; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008168:Lung / Q000473:pathology*; D008297:Male; D015427:Reperfusion Injury / Q000150:complications*