title: Serum IgG and IgA levels in polio and non-polio acute flaccid paralysis cases in western Uttar Pradesh, India.
abstract: OBJECTIVE
  IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and non-polio acute flaccid paralysis.
  
  
  METHODS
  932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA and IgG levels were determined by sandwich ELISA.
  
  
  RESULTS
  Mean (SD) IgA levels [0.87 (0.62)g/L; n=28] of virologically confirmed poliomyelitis cases were lower than those of virus negative [1.21 (0.83)g/L; n=612] and non-polio Enterovirus positive [1.22 (0.79)g/L; n=240] cases of acute flaccid paralysis. No significant difference was observed in the concentration of IgG among these groups.
  
  
  CONCLUSIONS
  IgA plays an important role in protection against poliomyelitis.
authors.affiliation: Enterovirus Research Center, Indian Council of Medical Research, Haffkine Institute Campus, Acharya Donde Marg, Parel, Mumbai, India. Correspondence to: Dr Jagadish Mohanrao Deshpande, Director, Enterovirus Reseach Center, Indian Council of Medical Research, Haffkine Institute Campus, Acharya Donde Marg, Parel, Mumbai 400 012, India. deshpandejm@gmail.com.
authors.forename: Madhu C
authors.initials: MC
authors.lastname: Mohanty
authors.forename: Uma P
authors.initials: UP
authors.lastname: Nalavade
authors.forename: Jagadish M
authors.initials: JM
authors.lastname: Deshpande
mesh_terms: D002675:Child, Preschool; D005243:Feces / Q000821:virology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D010264:Paraplegia / Q000453:epidemiology* / Q000276:immunology*; D011051:Poliomyelitis / Q000453:epidemiology* / Q000276:immunology*; D017955:Poliovirus / Q000276:immunology; D016036:Seroepidemiologic Studies
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G