title: IPEX Syndrome, FOXP3 and Cancer.
abstract: In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression. Potential mechanisms ofFOXP3inactivation and transcriptional regulation are discussed with recent advances. Finally, we point out current issues and a potential FOXP3-mediated therapeutic strategy as well as the reactivation of FOXP3 in patients with IPEX syndrome and cancer.
authors.affiliation: Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
authors.forename: Runhua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
authors.forename: Silin
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia 31404, USA.
authors.forename: Wei-Hsiung
authors.initials: WH
authors.lastname: Yang
authors.forename: Lizhong
authors.initials: L
authors.lastname: Wang
keywords: Cancer; FOXP3; IPEX; Syndrome; Tumor suppressors
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