title: Acupuncture treatment modulates the resting-state functional connectivity of brain regions in migraine patients without aura.
abstract: OBJECTIVE
  To investigate the modulatory effect of acupuncture treatment on the resting-state functional connectivity of brain regions in migraine without aura (MWoA) patients.
  
  
  METHODS
  Twelve MWoA patients were treated with standard acupuncture treatment for 4 weeks. All MWoA patients received resting-state functional magnetic resonance imaging (fMRI) scanning before and after acupuncture treatment. Another 12 normal subjects matched in age and gender were recruited to serve as healthy controls. The changes of restingstate functional connectivity in MWoA patients before and after the acupuncture treatment and those with the healthy controls were compared.
  
  
  RESULTS
  Before acupuncture treatment, the MWoA patients had significantly decreased functional connectivity in certain brain regions within the frontal and temporal lobe when compared with the healthy controls. After acupuncture treatment, brain regions showing decreased functional connectivity revealed significant reduction in MWoA patients compared with before acupuncture treatment.
  
  
  CONCLUSIONS
  Acupuncture treatment could increase the functional connectivity of brain regions in the intrinsic decreased brain networks in MWoA patients. The results provided further insights into the interpretation of neural mechanisms of acupuncture treatment for migraine.
authors.affiliation: Department of Neurology and Stroke Center, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology and Stroke Center, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Kuang-shi
authors.initials: KS
authors.lastname: Li
authors.affiliation: Department of Neurology and Stroke Center, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Liu
authors.affiliation: Department of Neurology and Stroke Center, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Cai-hong
authors.initials: CH
authors.lastname: Fu
authors.affiliation: Department of Acupuncture, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Magnetic Resonance Imaging, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China.
authors.forename: Zhong-jian
authors.initials: ZJ
authors.lastname: Tan
authors.affiliation: Department of Neurology and Stroke Center, Dongzhimen Hospital, the First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, 100700, China. rywendy1982@sina.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Ren
mesh_terms: D015670:Acupuncture Therapy; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D003710:Demography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020326:Migraine without Aura / Q000503:physiopathology*; D009415:Nerve Net / Q000503:physiopathology*; D012146:Rest; D016896:Treatment Outcome
keywords: acupuncture; functional connectivity; functional magnetic resonance imaging; migraine without aura; resting-state
references.citation: PLoS One. 2012;7(9):e45476
references.pmid: 23029036
references.citation: Cephalalgia. 2011 Aug;31(11):1220-31
references.pmid: 21816769
references.citation: PLoS One. 2012;7(12):e52927
references.pmid: 23285228
references.citation: NMR Biomed. 2012 May;25(5):806-12
references.pmid: 22020869
references.citation: PLoS One. 2012;7(4):e32960
references.pmid: 22496739
references.citation: NMR Biomed. 2013 Jan;26(1):58-64
references.pmid: 22674568
references.citation: Brain. 2012 Aug;135(Pt 8):2546-59
references.pmid: 22843414
references.citation: CMAJ. 2012 Mar 6;184(4):401-10
references.pmid: 22231691
references.citation: PLoS One. 2014 Jun 10;9(6):e99538
references.pmid: 24915066
references.citation: Cephalalgia. 2013 Aug;33(11):885-90
references.pmid: 23482725
references.citation: Cephalalgia. 2013 Jan;33(1):34-42
references.pmid: 23150889
references.citation: Pain. 2013 Mar;154(3):459-67
references.pmid: 23352757
references.citation: Headache. 2014 Apr;54(4):601-9
references.pmid: 24666114
references.citation: Lancet Neurol. 2009 Jun;8(6):560-8
references.pmid: 19446275
references.citation: Chin J Integr Med. 2009 Aug;15(4):248-50
references.pmid: 19688310
references.citation: BMJ. 2011 Jan 18;342:c7357
references.pmid: 21245119
references.citation: Forsch Komplementmed. 2012;19(4):197-201
references.pmid: 22964986
references.citation: Pain. 1986 May;25(2):215-21
references.pmid: 3725409
references.citation: Lancet Neurol. 2006 Apr;5(4):310-6
references.pmid: 16545747
references.citation: Pain. 2013 Sep;154(9):1738-42
references.pmid: 23693159
references.citation: Cephalalgia. 2004;24 Suppl 1:9-160
references.pmid: 14979299
references.citation: Evid Based Complement Alternat Med. 2013;2013:812568
references.pmid: 23737848
references.citation: Lancet Neurol. 2013 May;12 (5):454-61
references.pmid: 23578775
references.citation: J Headache Pain. 2013 Nov 08;14:89
references.pmid: 24207164
references.citation: Zhongguo Zhen Jiu. 2010 Apr;30(4):325-8
references.pmid: 20568442
references.citation: Mol Pain. 2010 Nov 02;6:73
references.pmid: 21044291
references.citation: Chin J Integr Med. 2014 Mar;20(3):184-93
references.pmid: 24615211
references.citation: Cephalalgia. 2012 Oct;32(14):1041-8
references.pmid: 22908362
references.citation: Headache. 2012 Apr;52(4):582-91
references.pmid: 22590713
references.citation: PLoS One. 2011;6(11):e27049
references.pmid: 22073251
references.citation: J Tradit Complement Med. 2013 Oct;3(4):213-20
references.pmid: 24716180
references.citation: Ann N Y Acad Sci. 2008 Mar;1124:1-38
references.pmid: 18400922
references.citation: Psychiatry Res. 1989 May;28(2):193-213
references.pmid: 2748771
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001218
references.pmid: 19160193
references.citation: Neurology. 2007 Jan 30;68(5):343-9
references.pmid: 17261680
references.citation: Ann Neurol. 2011 Nov;70(5):838-45
references.pmid: 22162064
references.citation: Cephalalgia. 2012 Jun;32(8):607-20
references.pmid: 22623760
references.citation: Eur J Neurol. 2012 Jan;19(1):155-62
references.pmid: 22175760
references.citation: Pain. 2011 Aug;152(8):1864-71
references.pmid: 21616596