title: Effectiveness of a desensitizing agent for topical and home use for dentin hypersensitivity: a randomized clinical trial.
abstract: OBJECTIVE
  To evaluate the effectiveness of a desensitizing gel for topical and home use for the treatment of dentin hypersensitivity (DH) by means of a 3-arm parallel, randomized, double blind clinical trial.
  
  
  METHODS
  107 participants were allocated to three groups: placebo gel (PG), test gel (TG) (5% sodium fluoride, 5% potassium oxalate, 10% strontium chloride) and 2% sodium fluoride gel (FG). DH measurement was performed by a single blind examiner by means of the visual analog scale (VAS) after tactile (blunt tipped probe), thermal (air blast) and osmotic (water blast) stimulus at time intervals of baseline, 7, 15 and 30 days.
  
  
  RESULTS
  The greatest reductions in DH were observed for the TG, with significant differences for FG in the thermal (Δ = -56 vs -30) and osmotic stimuli (Δ = -44 vs -18). Considering the percentage of participants with moderate/severe pain at 30 days, the TG demonstrated the lowest percentages, with significant differences in comparison with the other groups in thermal and osmotic stimuli. We can conclude that the test gel showed a greater reduction in DH than fluoride 2% and placebo gel, and maybe a treatment option for individuals with DH.
authors.forename: Raquel Pippi
authors.initials: RP
authors.lastname: Antoniazzi
authors.forename: Michely Ediani
authors.initials: ME
authors.lastname: Machado
authors.forename: Alessandra Pascotini
authors.initials: AP
authors.lastname: Grellmann
authors.forename: Roberto Christ Vianna
authors.initials: RC
authors.lastname: Santos
authors.forename: Fabricio Batistin
authors.initials: FB
authors.lastname: Zanatta
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003807:Dentin Sensitivity / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019815:Oxalic Acid / Q000008:administration & dosage*; D012969:Sodium Fluoride / Q000008:administration & dosage*; D013324:Strontium / Q000008:administration & dosage*
chemical_list: D012969:Sodium Fluoride; D019815:Oxalic Acid; C025700:strontium chloride; D013324:Strontium