title: A human breathing lung-on-a-chip.
abstract: Here we describe a microphysiological system that replicates the functional unit of the living human lung. This human "breathing lung-on-a-chip" microdevice provides unique capabilities to reconstitute three-dimensional microarchitecture, dynamic mechanical activity, and integrated physiological function of the alveolar-capillary interface. We demonstrate the potential of this microengineered biomimetic model for screening environmental particulates and modeling complex human disease processes.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Dongeun Dan
authors.initials: DD
authors.lastname: Huh
mesh_terms: D040761:Biomimetic Materials; D006801:Humans; D008168:Lung / Q000502:physiology*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*
keywords: lung; lung-on-a-chip; microfluidics; organ-on-a-chip
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