title: Clinical and angiographic outcomes of paclitaxel-eluting coronary stent implantation in hemodialysis patients: A prospective multicenter registry: The OUCH-TL study (outcome in hemodialysis of TAXUS Liberte).
abstract: BACKGROUND
  The outcome of percutaneous coronary intervention (PCI) has been reported to be poor in hemodialysis (HD) patients even in the drug-eluting stent era. We have reported relatively poor outcomes after sirolimus-eluting stent implantation in the OUCH study.
  
  
  METHODS
  The OUCH-TL study is a prospective, non-randomized, single-arm registry designed to assess the results of paclitaxel-eluting stent (PES) in HD patients with follow-up quantitative coronary angiography analysis. The primary endpoint was the occurrence of target-vessel failure (TVF) defined as cardiac death, myocardial infarction (MI), and target-vessel revascularization (TVR) at 12 months.
  
  
  RESULTS
  A total of 119 patients with 154 lesions were enrolled (one withdrawal). Mean age was 65±10 years, male gender was 79%, 89% of cases had stable coronary disease. Diabetic nephropathy was diagnosed in 61% of the patients. American College of Cardiology/American Heart Association type B2/C accounted for 96% of lesions and 22.7% of lesions were treated with Rotablator (Boston Scientific Corporation, Natick, MA, USA). Rates of TVF, death, MI, stent thrombosis and TVR at 12 months were 20.2%, 5.9%, 5.0%, 1.4%, and 12.6%, respectively. TVR was performed in 8.4% of the patients up to 12 months. Late loss in-stent was 0.48±0.61mm, and late loss in-segment was 0.37±0.61mm at 9 months. Binary restenosis in-stent was 10.3% and in-segment was 14.5%.
  
  
  CONCLUSIONS
  Outcomes of PES implantation in hemodialysis patients appears comparable to those of non-hemodialysis patients.
authors.affiliation: Teikyo University Hospital, Tokyo, Japan. Electronic address: PXE00364@nifty.com.
authors.forename: Ken
authors.initials: K
authors.lastname: Kozuma
authors.affiliation: Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Otsuka
authors.affiliation: Tokai University School of Medicine, Isehara, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikari
authors.affiliation: The Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Uehara
authors.affiliation: Kokura Memorial Hospital, Kitakyushu, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Yokoi
authors.affiliation: Iwatsuki Minami Hospital, Saitama, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Sano
authors.affiliation: Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Tanabe
authors.affiliation: Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hibi
authors.affiliation: Sekishinkai Sayama Hospital, Sayama, Japan.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Yamane
authors.affiliation: Toranomon Hospital, Tokyo, Japan.
authors.forename: Sugao
authors.initials: S
authors.lastname: Ishiwata
authors.affiliation: Itabashi Chuo Medical Center, Tokyo, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohta
authors.affiliation: Kikuna Memorial Hospital, Yokohama, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suematsu
authors.affiliation: Jichi Medical University Hospital, Shimotsuke, Japan.
authors.forename: Mio
authors.initials: M
authors.lastname: Nakayama
authors.affiliation: Sendai Kousei Hospital, Sendai, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Inoue
authors.affiliation: Teikyo University Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kyono
authors.affiliation: Teikyo University Hospital, Tokyo, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.affiliation: Teikyo University Hospital, Tokyo, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Isshiki
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology; D017239:Paclitaxel / Q000008:administration & dosage; D062645:Percutaneous Coronary Intervention / Q000295:instrumentation / Q000401:mortality*; D011446:Prospective Studies; D012042:Registries; D006435:Renal Dialysis; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000008:administration & dosage; D014481:United States
chemical_list: D050257:Tubulin Modulators; D017239:Paclitaxel
keywords: Coronary heart disease; Drug-eluting stent; Hemodialysis; Kidney; Prognosis