title: [Familial hypercholesterolemia in cardiac rehabilitation: a new field of interest].
abstract: Familial hypercholesterolemia (FH) is a frequently undiagnosed genetic disease characterized by substantial elevations of low-density lipoprotein cholesterol (LDL-C). The prevalence of heterozygous FH (HeFH) in the general population is 1:500 inhabitants, while the prevalence of homozygous FH (HoFH) is 1:1,000,000. If FH is not identified and aggressively treated at an early age, affected individuals have a 20-fold increased lifetime risk of coronary heart disease compared with the general population. This narrative review provide a concise overview of recommendations for diagnosis and treatment of adults and children with FH, and discuss the utility of considering FH as a comorbidity at the entry of cardiac rehabilitation programmes.
authors.forename: Marco
authors.initials: M
authors.lastname: Ambrosetti
authors.forename: Gabriella
authors.initials: G
authors.lastname: Malfatto
authors.forename: Anna
authors.initials: A
authors.lastname: Maria Cremona
authors.forename: Marcello
authors.initials: M
authors.lastname: Arca
authors.forename: Pompilio
authors.initials: P
authors.lastname: Faggiano
mesh_terms: D000328:Adult; D002648:Child; D003327:Coronary Disease / Q000453:epidemiology* / Q000534:rehabilitation; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors