title: Novel experimental rabbit model of anterior glottic web formation.
abstract: CONCLUSIONS
  The rabbit model of anterior glottic web (AGW) formation using the laryngofissure technique resulted in reproducible and stable AGW formation that may facilitate research into this area.
  
  
  OBJECTIVE
  To introduce and validate a novel experimental animal model of AGW formation using the rabbit.
  
  
  METHODS
  The inner larynges of eight New Zealand white rabbits were exposed through the laryngofissure technique. The mucosa of the bilateral true vocal fold was stripped off using the bevel of a needle tip. On the basis of the laryngoscopic findings at 8 weeks postoperatively, the extent of AGW was measured, and the success of this procedure was validated. Laryngeal specimens were sampled at 8 weeks for high-speed recording and histological analysis.
  
  
  RESULTS
  In seven (87.5%) rabbits, laryngoscopic examination revealed the formation of a scar band involving the anterior commissure. The mean extent of AGW ratio on the left and right sides was 0.58 ± 0.073 and 0.55 ± 0.075, respectively. The symmetric formation of AGW (p = 0.655, p = 0.128) and stability of the AGW procedure (p = 0.491, left; p = 0.501, right) were statistically validated. On high-speed recording, the vocal mucosal wave was hindered by AGW formation. Histologically, fibro-connective tissue, especially collagen fiber, was observed in the anterior commissure.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital & Seoul National University College of Medicine , Seoul.
authors.forename: Seong Keun
authors.initials: SK
authors.lastname: Kwon
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kim
authors.forename: Yoon-Jong
authors.initials: YJ
authors.lastname: Ryu
authors.forename: Soo Yeon
authors.initials: SY
authors.lastname: Kim
authors.forename: Hyun
authors.initials: H
authors.lastname: Chang
authors.forename: Myung Whun
authors.initials: MW
authors.lastname: Sung
authors.forename: J Hun
authors.initials: JH
authors.lastname: Hah
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005931:Glottis / Q000473:pathology*; D007828:Laryngoscopy / Q000379:methods*; D007829:Laryngostenosis / Q000473:pathology* / Q000601:surgery*; D008297:Male; D011817:Rabbits; D014827:Vocal Cords / Q000473:pathology
keywords: Stenosis; anterior commissure; laryngofissure technique; larynx