title: Alkaloids of the Annonaceae: occurrence and a compilation of their biological activities.
abstract: This chapter presents an overview of the chemistry and pharmacology of the alkaloids found in species of the Annonaceae family. The occurrence of alkaloids from Annonaceae species, as well as their chemical structures and pharmacological activities are summarized in informative and easy-to-understand tables. Within the Annonaceae family, the genera Annona, Duguetia, and Guatteria have led to many important publications. Valuable and comprehensive information about the structure of these alkaloids is provided. The alkaloids of the aporphine type represent the predominant group in this family. Many of the isolated alkaloids exhibit unique structures. In addition to the chemical structures, the pharmacological activities of some alkaloids are also presented in this chapter. Thus, the leishmanicidal, antimicrobial, antitumor, cytotoxic, and antimalarial activities observed for these alkaloids are highlighted. The chapter is presented as a contribution for the scientific community, mainly to enable the search for alkaloids in species belonging to the Annonaceae family.
authors.forename: Ana Silvia Suassuna Carneiro
authors.initials: AS
authors.lastname: Lúcio
authors.forename: Jackson Roberto Guedes da Silva
authors.initials: JR
authors.lastname: Almeida
authors.forename: Emídio Vasconcelos Leitão
authors.initials: EV
authors.lastname: Da-Cunha
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
authors.forename: Jos Maria
authors.initials: JM
authors.lastname: Barbosa Filho
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000145:classification / Q000494:pharmacology*; D031041:Annona / Q000737:chemistry; D029061:Annonaceae / Q000737:chemistry* / Q000145:classification; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry / Q000494:pharmacology; D031043:Guatteria / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; C081279:aporphine