title: An exposure and health risk assessment of lead (Pb) in lipstick.
abstract: Lead (Pb) content in lipstick and other consumer products has become an increasing concern. In 2010, the United States Food and Drug Administration tested 400 lipstick samples and found a maximum Pb concentration of 7.19 ppm. To assess the safety of lipstick in adults that chronically apply lipstick as well as instances where children might incidentally ingest lipstick products, the United States Environmental Protection Agency's (US EPA) Adult Lead Model and Integrated Exposure Uptake Biokinetic Model for Lead in Children were used to determine the blood Pb concentrations of adults and children ingesting varying amounts of lipstick of different Pb concentrations. Modeled blood Pb concentrations were compared with oral ingestion guidelines and to the Centers for Disease Control and the US EPA's actionable blood Pb levels of 5 and 10 µg/dL. Background Pb exposure was the primary contributor to estimated blood Pb levels (BLLs) in children and adults, and Pb exposure from lipstick did not significantly increase estimated BLLs. These results suggest that the safety of consumer products and cosmetics should be assessed not only by the presence and amounts of hazardous contents, but also in conjunction with an assessment of estimated background exposures and comparison to health-based standards.
authors.affiliation: Cardno ChemRisk, LLC, 101 2nd St., Suite 700, San Francisco, CA 94105, USA. Electronic address: andrew.monnot@cardno.com.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Monnot
authors.affiliation: Cardno ChemRisk, LLC, 20 Stanwix St., Suite 505, Pittsburgh, PA 15222, USA.
authors.forename: Whitney V
authors.initials: WV
authors.lastname: Christian
authors.affiliation: Cardno ChemRisk, LLC, 20 Stanwix St., Suite 505, Pittsburgh, PA 15222, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Abramson
authors.affiliation: Syracuse Research Corporation, Scarborough, ME 04074, USA.
authors.forename: Mark H
authors.initials: MH
authors.lastname: Follansbee
mesh_terms: D003257:Consumer Product Safety / Q000592:standards; D003358:Cosmetics / Q000737:chemistry*; D006801:Humans; D007854:Lead / Q000097:blood / Q000737:chemistry* / Q000633:toxicity*; D014481:United States
chemical_list: D003358:Cosmetics; D007854:Lead
keywords: Lead; Lipstick; Risk assessment