title: Water-soluble L-cysteine-coated FePt nanoparticles as dual MRI/CT imaging contrast agent for glioma.
abstract: Nanoparticles (NPs) are advantageous for the delivery of diagnosis agents to brain tumors. In this study, we attempted to develop an L-cysteine coated FePt (FePt-Cys) NP as MRI/CT imaging contrast agent for the diagnosis of malignant gliomas. FePt-Cys NPs were synthesized through a co-reduction route, which was characterized by transmission electron microscopy, high-resolution transmission electron microscopy, powder X-ray diffraction, Fourier transform infrared spectroscopy, and dynamic light scattering. The MRI and CT imaging ability of FePt-Cys NPs was evaluated using different gliomas cells (C6, SGH44, U251) as the model. Furthermore, the biocompatibility of the as-synthesized FePt-Cys NPs was evaluated using three different cell lines (ECV304, L929, and HEK293) as the model. The results showed that FePt-Cys NPs displayed excellent biocompatibility and good MRI/CT imaging ability, thereby indicating promising potential as a dual MRI/CT contrast agent for the diagnosis of brain malignant gliomas.
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Shuyan
authors.initials: S
authors.lastname: Liang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People's Republic of China ; Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, People's Republic of China ; Biomedical Material and Engineering Center of Hubei Province, Wuhan University of Technology, Wuhan, People's Republic of China.
authors.forename: Qingzhi
authors.initials: Q
authors.lastname: Wu
authors.affiliation: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
mesh_terms: D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D005910:Glioma / Q000378:metabolism*; D057809:HEK293 Cells; D006801:Humans; D007501:Iron / Q000737:chemistry* / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media; D010984:Platinum; D007501:Iron; D003545:Cysteine
keywords: CT; MRI; glioma
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2006 Jan;63(1):160-3
references.pmid: 15955726
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2011 May;78(5):1515-24
references.pmid: 21377921
references.citation: Toxicol In Vitro. 2014 Aug;28(5):990-8
references.pmid: 24768613
references.citation: Adv Mater. 2011 Jun 24;23(24):H136-50
references.pmid: 21506172
references.citation: J Am Chem Soc. 2010 Sep 29;132(38):13270-8
references.pmid: 20572667
references.citation: Int J Nanomedicine. 2014 Apr 17;9:1919-29
references.pmid: 24790434
references.citation: J Colloid Interface Sci. 2005 Oct 15;290(2):444-9
references.pmid: 15935370
references.citation: Cancer Treat Rev. 2014 Mar;40(2):229-41
references.pmid: 22858248
references.citation: J Am Chem Soc. 2008 Sep 3;130(35):11828-33
references.pmid: 18681432
references.citation: Biomaterials. 2011 Jan;32(2):495-502
references.pmid: 20970851
references.citation: Mol Neurobiol. 2013 Oct;48(2):368-79
references.pmid: 23832531
references.citation: Biomaterials. 2014 Jun;35(19):5226-39
references.pmid: 24695093
references.citation: Acc Chem Res. 2009 Aug 18;42(8):1097-107
references.pmid: 19476332
references.citation: Nano Res. 2011 Nov;4(11):1163-1173
references.pmid: 29423130
references.citation: J Mater Chem B. 2014 Mar 21;2(11):1521-1529
references.pmid: 32261370
references.citation: Tumour Biol. 2014 Mar;35(3):2445-9
references.pmid: 24163108
references.citation: Clin Pharmacol Ther. 2009 May;85(5):531-4
references.pmid: 19242401
references.citation: Biomaterials. 2014 Jan;35(4):1249-56
references.pmid: 24211079
references.citation: J Control Release. 2011 Nov 7;155(3):393-9
references.pmid: 21763736
references.citation: Nano Lett. 2005 Jun;5(6):1003-8
references.pmid: 15943433
references.citation: Nanomedicine (Lond). 2008 Aug;3(4):495-505
references.pmid: 18694312
references.citation: Neurotoxicology. 2013 Jan;34:243-53
references.pmid: 22995439
references.citation: Mol Pharm. 2014 Jun 2;11(6):1823-34
references.pmid: 24779677
references.citation: Int J Nanomedicine. 2012;7:3295-307
references.pmid: 22848161
references.citation: J Biomed Mater Res A. 2014 Jun;102(6):1726-36
references.pmid: 23776183
references.citation: J Colloid Interface Sci. 2014 Mar 1;417:159-65
references.pmid: 24407672
references.citation: Biomaterials. 2008 Feb;29(4):487-96
references.pmid: 17964647
references.citation: Int J Nanomedicine. 2011;6:591-603
references.pmid: 21674016
references.citation: J Nanosci Nanotechnol. 2014 Jan;14(1):415-32
references.pmid: 24730272
references.citation: J Am Chem Soc. 2010 Oct 27;132(42):15022-9
references.pmid: 20919679
references.citation: Chem Soc Rev. 2009 Sep;38(9):2532-42
references.pmid: 19690734
references.citation: Acc Chem Res. 2011 Oct 18;44(10):875-82
references.pmid: 21661754
references.citation: Biochim Biophys Acta. 2014 Jun;1840(6):1657-69
references.pmid: 24361614
references.citation: J Colloid Interface Sci. 2014 Dec 1;435:67-74
references.pmid: 25218049
references.citation: Small. 2013 Dec 20;9(24):4123-9
references.pmid: 23873826
references.citation: ACS Nano. 2014 Feb 25;8(2):1231-42
references.pmid: 24397730
references.citation: Small. 2010 May 7;6(9):1022-31
references.pmid: 20394071
references.citation: N Engl J Med. 2008 Jul 31;359(5):492-507
references.pmid: 18669428
references.citation: Int J Nanomedicine. 2014;9:273-87
references.pmid: 24421639
references.citation: Biomaterials. 2014 May;35(14):4319-32
references.pmid: 24565520
references.citation: Nanomedicine (Lond). 2013 Oct;8(10):1601-9
references.pmid: 23265347
references.citation: Adv Drug Deliv Rev. 2014 Feb;66:42-57
references.pmid: 24060923