title: Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach.
abstract: A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity.
authors.affiliation: Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China. zly0605@ustc.edu.cn.
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhang
authors.forename: Jun Cheng
authors.initials: JC
authors.lastname: Er
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jun Jie
authors.initials: JJ
authors.lastname: Heng
authors.forename: Animesh
authors.initials: A
authors.lastname: Samanta
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
authors.forename: Chi-Lik Ken
authors.initials: CL
authors.lastname: Lee
mesh_terms: D002232:Carbocyanines / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D054856:G-Quadruplexes; D008958:Models, Molecular; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D002232:Carbocyanines; D005456:Fluorescent Dyes; D054852:Small Molecule Libraries; C085321:cyanine dye 5