title: Different gonadotropin releasing hormone agonist doses for the final oocyte maturation in high-responder patients undergoing in vitro fertilization/intra-cytoplasmic sperm injection.
abstract: BACKGROUND
  Efficacy of gonadotropin releasing hormone agonists (GnRH-a) for ovulation in high-responders.
  
  
  OBJECTIVE
  The aim of the current study is to compare the impact of different GnRH-a doses for the final oocyte maturation on cycle outcomes and ovarian hyperstimulation syndrome (OHSS) rates in high-responder patients undergoing ovarian stimulation.
  
  
  METHODS
  Electronic medical records of a private in vitro fertilization center, a retrospective analysis.
  
  
  METHODS
  A total of 77 high-responder cases were detected receiving GnRH-a. Group I consisted of 38 patients who received 1 mg of agonist and Group II consisted of 39 patients who received 2 mg of agonist.
  
  
  METHODS
  In order to compare groups, Student's t-test, Mann-Whitney U-test, Pearson's Chi-square test or Fisher's exact test were used where appropriate. A P < 0.05 was considered as statistically significant.
  
  
  RESULTS
  Number of retrieved oocytes (17.5 vs. 15.0, P = 0.510), implantation rates (46% vs. 55.1%, P = 0.419) and clinical pregnancy rates (42.1% vs. 38.5%, P = 0.744) were similar among groups. There were no mild or severe OHSS cases detected in Group I. Only 1 mild OHSS case was detected in Group II.
  
  
  CONCLUSIONS
  A volume of 1 or 2 mg leuprolide acetate yields similar outcomes when used for the final oocyte maturation in high-responder patients.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Turkey.
authors.forename: Emre Goksan
authors.initials: EG
authors.lastname: Pabuccu
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Turkey ; Centrum Clinic Women Healthcare and IVF Center, Ankara, Malatya, Turkey ; Dogu Fertil IVF Center, Malatya, Turkey.
authors.forename: Recai
authors.initials: R
authors.lastname: Pabuccu
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Turkey.
authors.forename: Gamze Sinem
authors.initials: GS
authors.lastname: Caglar
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Yılmaz
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Ufuk University, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Yarcı
keywords: Agonist-trigger; antagonist; high-responder; in vitro fertilization; leuprolide; ovarian hyperstimulation syndrome
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