title: Improving surface and mechanical properties of alginate films by using ethanol as a co-solvent during external gelation.
abstract: Alginate films were prepared by solution casting method and further ionically crosslinked in a calcium chloride (CaCl2) water solution containing different proportions (0-40% v/v) of ethanol as the co-solvent. The addition of ethanol into the CaCl2 water solution was found to improve the visual appearance, thickness, surface homogeneity, and mechanical properties of the films, which can be attributed to the reduced swelling degree of films during crosslinking process. Furthermore, Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDS) analysis indicated that the incorporation of ethanol into the crosslinking solution did not detract from the uniformity of crosslinking throughout the film matrix. However, the swelling degree and calcium content determination indicated that the Ca(2+) crosslinking degree decreased when the ethanol proportion exceeded 30% v/v. Consequently, this study introduces a green, efficient, and simple technique for the preparation of calcium alginate films with excellent surface appearance and mechanical properties for pharmaceutical products.
authors.affiliation: School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Jiwei
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China. Electronic address: hejinmei@hit.edu.cn.
authors.forename: Jinmei
authors.initials: J
authors.lastname: He
authors.affiliation: School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Yudong
authors.initials: Y
authors.lastname: Huang
authors.affiliation: School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Dalong
authors.initials: D
authors.lastname: Li
authors.affiliation: Weihai JieRui Medical Co., Ltd., Weihai 264209, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Chen
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002122:Calcium Chloride / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D018625:Microscopy, Atomic Force; D012997:Solvents / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D007477:Ions; D012997:Solvents; D000431:Ethanol; D020723:Glucuronic Acid; D002122:Calcium Chloride
keywords: Alginate; Calcium; Ethanol; External gelation; Film