title: Ethionamide-induced Pellagra.
abstract: Pellagra is a disorder characterized by dermatitis, diarrhea, dementia and eventually death, resulting from a deficiency of niacin or its precursor tryptophan. Ethionamide (a second-line antituberculosis agent)-induced pellagra is rarely encountered in clinical practice. Prompt diagnosis and treatment with nicotinamide can prevent life-threatening complications. To date, only three cases have been reported. We report a 13-year-old girl presenting with ethionamide-induced pellagra that resolved after the administration of niacin.
authors.affiliation: Pediatric TB Clinic, B J Wadia Hospital for Children, Mumbai 400012, India.
authors.forename: Yashashree
authors.initials: Y
authors.lastname: Gupta
authors.affiliation: Pediatric TB Clinic, B J Wadia Hospital for Children, Mumbai 400012, India Consultant in Pediatric Infectious Diseases and Pediatric Hepatology, Nanavati Hospital, Mumbai 400056, India irashah@pediatriconcall.com.
authors.forename: Ira
authors.initials: I
authors.lastname: Shah
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005000:Ethionamide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009525:Niacin / Q000627:therapeutic use; D010383:Pellagra / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D009525:Niacin; D005000:Ethionamide
keywords: Ethionamide; niacin; pellagra