title: Current challenges in meeting global iodine requirements.
abstract: Iodine deficiency is a global problem of immense magnitude afflicting 2 billion of the world's population. The adverse effects of iodine deficiency in humans, collectively termed iodine deficiency disorders, result from decreased thyroid hormone production and action, and vary in severity from thyroid enlargement (goiter) to severe, irreversible brain damage, termed endemic cretinism. Thyroid hormone is essential throughout life, but it is critical for normal brain development in the fetus and throughout childhood. During pregnancy, maternal thyroid hormone production must increase by 25-50% to meet maternal-fetal requirements. The principal sources of iodine in the diet include milk and dairy products, seafoods and foods with added iodized salt. Vegetables, fruits and cereals are generally poor sources of iodine because most of our soils and water supplies are deficient in iodine. The accepted solution to the problem is Universal Salt Iodization where all salt for human and animal consumption is iodized at a level of 20-40 µg/g. In principle, mandatory fortification represents the most effective public health strategy where safety and efficacy can be assured and there is a demonstrated need for the nutrient in the population. Voluntary fortification of salt and other foods has many limitations and few benefits. Iodine supplementation is a useful, but expensive, inefficient and unsustainable strategy for preventing iodine deficiency. The current worldwide push to decrease salt intake to prevent cardiovascular disease presents an entirely new challenge in addressing iodine deficiency in both developing and developed countries.
authors.affiliation: International Council for Control of Iodine Deficiency Disorders, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
authors.forename: Creswell J
authors.initials: CJ
authors.lastname: Eastman
authors.forename: Pieter
authors.initials: P
authors.lastname: Jooste
mesh_terms: D004032:Diet; D019587:Dietary Supplements; D005527:Food, Fortified; D014943:Global Health; D006042:Goiter / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007455:Iodine / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency; D009751:Nutritional Requirements; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000097:blood
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007455:Iodine