title: In vivo antitumor potential of Ipomoea pes-caprae on melanoma cancer.
abstract: BACKGROUND
  The incidence of skin cancers is rising gradually. The treatment of melanoma is also necessary to prevent the spread of cancer to other body organs. Scientific literatures have not documented any evidence of the antitumor potential of Ipomoea pes-caprae on melanoma.
  
  
  OBJECTIVE
  Explore in vivo antitumor potential of I. pes-caprae on melanoma cancer.
  
  
  METHODS
  Petroleum ether (60°C-80°C), methanolic and aqueous extracts, and swaras prepared from the whole herb of I. pes-caprae were assessed for their antitumor activity. The extracts and swaras at doses of 25 and 50 mg/kg b. wt. were administered intraperitoneal along with chemo and radiotherapy for 40 days for exploring antitumor activity against melanoma cancer (B16F10) in male C57BL mice. The results obtained from tumor volume, and histopathological studies were compared with the control and dacarbazine used as a standard.
  
  
  RESULTS
  Antitumor effect of I. pes-caprae extracts and swaras on melanoma cancer was found to be significant (P < 0.01) compared to normal control. The tumor volume inhibition against tumor-bearing mice, although differed from each other, was concentration dependent. Administration of plant extracts and swaras from the day 1 since tumor inducted. The induction of tumor was found delayed by 10-15 days and the tumor volume on the day 40 was similar to the Dacarbazine treatment used as a standard.
  
  
  CONCLUSIONS
  The results obtained from the tumor volume and histopathological studies clearly revealed the antitumor potential of I. pes-caprae on melanoma cancer.
authors.affiliation: Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Manigauha
authors.affiliation: Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh, India.
authors.forename: M D
authors.initials: MD
authors.lastname: Kharya
authors.affiliation: Research Division, Jawaharlal Nehru Cancer Hospital and Research Centre, Madhya Pradesh, India.
authors.forename: N
authors.initials: N
authors.lastname: Ganesh
keywords: Chemo and radiotherapy; Ipomoea pes-caprae; dacarbazine; enzymatic antioxidants; melanoma cancer; tumor volume
references.citation: Free Radic Biol Med. 2005 Nov 15;39(10):1385-98
references.pmid: 16257648
references.citation: Science. 1973 Feb 9;179(4073):588-90
references.pmid: 4686466
references.citation: Planta Med. 2004 Aug;70(8):691-705
references.pmid: 15326546
references.citation: J Lab Clin Med. 1991 Jul;118(1):7-16
references.pmid: 2066646
references.citation: Drugs. 1991 Oct;42(4):569-605
references.pmid: 1723362
references.citation: J Agric Food Chem. 2002 Aug 14;50(17):4791-5
references.pmid: 12166961
references.citation: Methods Enzymol. 1984;105:121-6
references.pmid: 6727660
references.citation: J Invest Dermatol. 2000 May;114(5):935-40
references.pmid: 10771474
references.citation: Oncologist. 2006 Jul-Aug;11(7):732-41
references.pmid: 16880232
references.citation: J Biol Chem. 1990 Jul 15;265(20):11919-27
references.pmid: 2195028
references.citation: Semin Oncol. 2005 Apr;32(2 Suppl 4):S24-38
references.pmid: 16015552
references.citation: J Ethnopharmacol. 2006 Dec 6;108(3):340-8
references.pmid: 16846707
references.citation: J Ethnopharmacol. 1991 Oct;35(1):65-9
references.pmid: 1684405
references.citation: Integr Cancer Ther. 2005 Sep;4(3):219-29
references.pmid: 16113029
references.citation: Molecules. 2011 Sep 29;16(10):8273-91
references.pmid: 21959299
references.citation: Anal Biochem. 1971 Nov;44(1):276-87
references.pmid: 4943714
references.citation: Anticancer Res. 2010 Jun;30(6):1911-9
references.pmid: 20651334
references.citation: Anal Biochem. 1972 Jun;47(2):389-94
references.pmid: 4556490
references.citation: Anal Biochem. 1979 Jun;95(2):351-8
references.pmid: 36810
references.citation: Methods Enzymol. 1984;105:114-21
references.pmid: 6727659
references.citation: Cell. 1994 Aug 26;78(4):539-42
references.pmid: 8069905
references.citation: Planta Med. 2003 Mar;69(3):193-201
references.pmid: 12677520