title: Fronto-Parietal Network Reconfiguration Supports the Development of Reasoning Ability.
abstract: The goal of this fMRI study was to examine how well developmental improvements in reasoning ability can be explained by changes in functional connectivity between specific nodes in prefrontal and parietal cortices. To this end, we examined connectivity within the lateral fronto-parietal network (LFPN) and its relation to reasoning ability in 132 children and adolescents aged 6-18 years, 56 of whom were scanned twice over the course of 1.5 years. Developmental changes in strength of connections within the LFPN were most prominent in late childhood and early adolescence. Reasoning ability was related to functional connectivity between left rostrolateral prefrontal cortex (RLPFC) and inferior parietal lobule (IPL), but only among 12-18-year olds. For 9-11-year olds, reasoning ability was most strongly related to connectivity between left and right RLPFC; this relationship was mediated by working memory. For 6-8-year olds, significant relationships between connectivity and performance were not observed; in this group, processing speed was the primary mediator of improvement in reasoning ability. We conclude that different connections best support reasoning at different points in development and that RLPFC-IPL connectivity becomes an important predictor of reasoning during adolescence.
authors.forename: Carter
authors.initials: C
authors.lastname: Wendelken
authors.forename: Emilio
authors.initials: E
authors.lastname: Ferrer
authors.forename: Kirstie J
authors.initials: KJ
authors.lastname: Whitaker
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Bunge
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D001931:Brain Mapping; D002648:Child; D002657:Child Development; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009434:Neural Pathways / Q000254:growth & development / Q000502:physiology; D010296:Parietal Lobe / Q000254:growth & development / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology*
keywords: adolescent; child; development; dorsolateral; functional connectivity; inferior parietal lobule; parietal cortex; prefrontal cortex; processing speed; reasoning; rostrolateral; working memory
references.citation: Genome Res. 2012 Apr;22(4):611-22
references.pmid: 22300767
references.citation: Neuroimage. 2009 May 15;46(1):338-42
references.pmid: 19457362
references.citation: J Cogn Neurosci. 2011 Nov;23(11):3483-97
references.pmid: 21568632
references.citation: Neuroimage. 2012 Mar;60(1):623-32
references.pmid: 22233733
references.citation: Nat Neurosci. 1999 Oct;2(10):861-3
references.pmid: 10491603
references.citation: Neuropsychologia. 2011 Jul;49(8):2185-98
references.pmid: 21371485
references.citation: Psychoneuroendocrinology. 2011 Sep;36(8):1101-13
references.pmid: 21641727
references.citation: Neuroimage. 2007 Mar;35(1):396-405
references.pmid: 17239622
references.citation: Brain Res. 2012 Jan 5;1428:13-23
references.pmid: 21129363
references.citation: Dev Cogn Neurosci. 2012 Feb 15;2 Suppl 1:S139-51
references.pmid: 22682903
references.citation: Transl Psychiatry. 2013;3:e238
references.pmid: 23462989
references.citation: PLoS Comput Biol. 2009 May;5(5):e1000395
references.pmid: 19492086
references.citation: Psychol Sci. 2004 Mar;15(3):155-63
references.pmid: 15016286
references.citation: Cereb Cortex. 2005 Mar;15(3):239-49
references.pmid: 15238433
references.citation: J Cogn Neurosci. 2010 May;22(5):837-47
references.pmid: 19320546
references.citation: Cereb Cortex. 2014 Sep;24(9):2283-96
references.pmid: 23563963
references.citation: Neuroimage. 2012 Jan 2;59(1):431-8
references.pmid: 21810475
references.citation: PLoS Comput Biol. 2009 May;5(5):e1000381
references.pmid: 19412534
references.citation: Neuroimage. 2012 Feb 1;59(3):2142-54
references.pmid: 22019881
references.citation: Science. 2003 Nov 14;302(5648):1181-5
references.pmid: 14615530
references.citation: Dev Psychol. 2002 Jan;38(1):115-42
references.pmid: 11806695
references.citation: Neuron. 2010 Jul 15;67(1):156-70
references.pmid: 20624599
references.citation: Neuron. 2009 Jun 11;62(5):733-43
references.pmid: 19524531
references.citation: Sci Rep. 2012;2:411
references.pmid: 22624092
references.citation: Cereb Cortex. 2002 May;12(5):477-85
references.pmid: 11950765
references.citation: J Cogn Neurosci. 2008 Apr;20(4):682-93
references.pmid: 18052787
references.citation: J Neurosci. 2011 Mar 16;31(11):4087-100
references.pmid: 21411650
references.citation: J Exp Child Psychol. 2006 Jul;94(3):249-73
references.pmid: 16620867
references.citation: J Comp Neurol. 1997 Oct 20;387(2):167-78
references.pmid: 9336221
references.citation: J Cogn Neurosci. 2007 Dec;19(12):2082-99
references.pmid: 17892391
references.citation: Neuron. 2011 Nov 17;72(4):665-78
references.pmid: 22099467
references.citation: Dev Psychol. 2004 Nov;40(6):935-52
references.pmid: 15535749
references.citation: Brain Res. 2006 Jun 22;1096(1):125-37
references.pmid: 16750818
references.citation: J Neurosci. 2012 Jun 27;32(26):8988-99
references.pmid: 22745498
references.citation: Hum Brain Mapp. 2013 Dec;34(12):3299-307
references.pmid: 23008156
references.citation: Dev Sci. 2009 Jan;12(1):55-66
references.pmid: 19120413
references.citation: J Neurophysiol. 2008 Dec;100(6):3328-42
references.pmid: 18799601
references.citation: Cereb Cortex. 2010 Mar;20(3):524-33
references.pmid: 19549622
references.citation: J Neurosci. 2011 Nov 23;31(47):17260-8
references.pmid: 22114292
references.citation: Dev Sci. 2010 Nov;13(6):F15-24
references.pmid: 20977551
references.citation: Prog Brain Res. 1994;102:227-43
references.pmid: 7800815
references.citation: Dev Sci. 2013 Nov;16(6):941-51
references.pmid: 24118718
references.citation: J Neurosci. 2013 Mar 13;33(11):4796-803
references.pmid: 23486950
references.citation: J Neurosci. 2007 Feb 28;27(9):2349-56
references.pmid: 17329432
references.citation: Hum Brain Mapp. 2012 Aug;33(8):1952-63
references.pmid: 21834102
references.citation: PLoS Biol. 2009 Jul;7(7):e1000157
references.pmid: 19621066
references.citation: Brain Lang. 2010 May;113(2):59-64
references.pmid: 20206985
references.citation: Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13281-6
references.pmid: 21788513
references.citation: Dev Cogn Neurosci. 2013 Jul;5:40-50
references.pmid: 23328350
references.citation: Front Hum Neurosci. 2008 Mar 28;1:8
references.pmid: 18958222
references.citation: Neuroimage. 2013 Sep;78:426-38
references.pmid: 23624492
references.citation: Neuron. 2014 Dec 3;84(5):906-17
references.pmid: 25475185
references.citation: Cereb Cortex. 2008 Apr;18(4):915-29
references.pmid: 17652464
references.citation: Neuroimage. 2001 Nov;14(5):1136-49
references.pmid: 11697945
references.citation: Neuroimage. 2012 Feb 1;59(3):2831-8
references.pmid: 21982934
references.citation: Hum Brain Mapp. 2014 Jul;35(7):3262-76
references.pmid: 25050424
references.citation: Hum Brain Mapp. 2012 Jun;33(6):1393-406
references.pmid: 21557387
references.citation: Neuropsychologia. 2013 Feb;51(3):464-71
references.pmid: 23206538
references.citation: Front Neurosci. 2009 May 01;3(1):46-51
references.pmid: 19753096
references.citation: Neuron. 2014 Jul 2;83(1):238-51
references.pmid: 24991964
references.citation: Acta Psychol (Amst). 1994 Aug;86(2-3):199-225
references.pmid: 7976467
references.citation: Brain Cogn. 2009 Feb;69(1):1-10
references.pmid: 18835075
references.citation: J Neurosci. 2009 Jun 10;29(23):7619-24
references.pmid: 19515930