title: Antioxidant status in peri- and postmenopausal women.
abstract: Menopause is a risk factor for oxidative stress. The aim of our study is to assess antioxidant system parameters (α-tocopherol, retinol, reduced glutathione, total antioxidant activity) in peri- and postmenopausal women. The antioxidant defense activity by estimation of total antioxidant activity, α-tocopherol, retinol, oxidized and reduced glutathione levels was studied in women of reproductive age (n=37), in perimenopausal (n=41) and postmenopausal women (n=41). In our study we used spectrofluorofotometer methods. Statistical analysis was performed by non-parametric tests with p<0.05 as the level of significance. The results of our study showed the decrease of α-tocopherol and retinol concentrations and the increase of oxidized glutathione level in blood serum both in perimenopausal and postmenopausal women, the total antioxidant activity of blood serum was decreased in postmenopausal women only. The results of our study demonstrate that decrease of antioxidant defense system resources depends on the menopausal phase.
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Lubov
authors.initials: L
authors.lastname: Kolesnikova
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia. Electronic address: natkor_84@mail.ru.
authors.forename: Natalya
authors.initials: N
authors.lastname: Semenova
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Irina
authors.initials: I
authors.lastname: Madaeva
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Larisa
authors.initials: L
authors.lastname: Suturina
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Solodova
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Grebenkina
authors.affiliation: Scientific Centre of Family Health and Human Reproduction Problems, Department of Reproductive Pathophysiology, Irkutsk, Russia.
authors.forename: Marina
authors.initials: M
authors.lastname: Darenskaya
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D005978:Glutathione / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D008875:Middle Aged; D018384:Oxidative Stress; D047648:Perimenopause / Q000097:blood*; D017698:Postmenopause / Q000097:blood*; D014801:Vitamin A / Q000097:blood; D055815:Young Adult; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D014801:Vitamin A; D005978:Glutathione; D024502:alpha-Tocopherol; D019803:Glutathione Disulfide
keywords: Antioxidant system; Perimenopause; Postmenopause