title: Activation of corticostriatal circuitry relieves chronic neuropathic pain.
abstract: Neural circuits that determine the perception and modulation of pain remain poorly understood. The prefrontal cortex (PFC) provides top-down control of sensory and affective processes. While animal and human imaging studies have shown that the PFC is involved in pain regulation, its exact role in pain states remains incompletely understood. A key output target for the PFC is the nucleus accumbens (NAc), an important component of the reward circuitry. Interestingly, recent human imaging studies suggest that the projection from the PFC to the NAc is altered in chronic pain. The function of this corticostriatal projection in pain states, however, is not known. Here we show that optogenetic activation of the PFC produces strong antinociceptive effects in a rat model (spared nerve injury model) of persistent neuropathic pain. PFC activation also reduces the affective symptoms of pain. Furthermore, we show that this pain-relieving function of the PFC is likely mediated by projections to the NAc. Thus, our results support a novel role for corticostriatal circuitry in pain regulation.
authors.affiliation: Department of Anesthesiology.
authors.forename: Michelle
authors.initials: M
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology.
authors.forename: Toby R
authors.initials: TR
authors.lastname: Manders
authors.affiliation: Department of Anesthesiology.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Eberle
authors.affiliation: Department of Anesthesiology.
authors.forename: Chen
authors.identifier: http://orcid.org/0000-0003-3571-6554
authors.initials: C
authors.lastname: Su
authors.affiliation: Department of Otolaryngology, Department of Neuroscience & Physiology, New York University School of Medicine, New York, New York 10016, Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute for Biomolecular Medicine, New York, New York 10016, and.
authors.forename: James
authors.initials: J
authors.lastname: D'amour
authors.affiliation: Department of Anesthesiology.
authors.forename: Runtao
authors.identifier: http://orcid.org/0000-0002-0400-4418
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology.
authors.forename: Hau Yueh
authors.initials: HY
authors.lastname: Lin
authors.affiliation: Department of Bioengineering, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California 94305.
authors.forename: Karl
authors.initials: K
authors.lastname: Deisseroth
authors.affiliation: Department of Otolaryngology, Department of Neuroscience & Physiology, New York University School of Medicine, New York, New York 10016, Molecular Neurobiology Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute for Biomolecular Medicine, New York, New York 10016, and.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Froemke
authors.affiliation: Department of Anesthesiology, Department of Neuroscience & Physiology, New York University School of Medicine, New York, New York 10016, jing.wang2@nyumc.org.
authors.forename: Jing
authors.identifier: http://orcid.org/0000-0003-1580-1356
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D008297:Male; D009434:Neural Pathways / Q000502:physiology*; D009437:Neuralgia / Q000503:physiopathology* / Q000628:therapy*; D009714:Nucleus Accumbens / Q000166:cytology / Q000502:physiology*; D062308:Optogenetics; D010147:Pain Measurement; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D051381:Rats
keywords: affective; nucleus accumbens; optogenetics; pain; prefrontal cortex
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