title: Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host.
abstract: Remarkable progress in structural biology has equipped virologists with insight into structures of viral proteins and virions at increasingly high resolution. Structural information has been used extensively to address fundamental questions about virtually all aspects of how viruses replicate in cells, interact with the host, and in the design of antiviral compounds. However, many critical aspects of virology exist outside the snapshots captured by traditional methods used to generate high-resolution structures. Like all proteins, viral proteins are not static structures. The conformational flexibility and dynamics of proteins play a significant role in protein-protein interactions, and in the structure and biology of virus particles. This review will discuss the implications of the dynamics of viral proteins on the biology, antigenicity, and immunogenicity of flaviviruses.
authors.affiliation: Departments of Biological Sciences and Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: kuhnr@purdue.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kuhn
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: dowdka@mail.nih.gov.
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Dowd
authors.affiliation: Departments of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. Electronic address: cbp@purdue.edu.
authors.forename: Carol
authors.initials: C
authors.lastname: Beth Post
authors.affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: piersontc@mail.nih.gov.
authors.forename: Theodore C
authors.initials: TC
authors.lastname: Pierson
mesh_terms: D000956:Antigens, Viral / Q000737:chemistry / Q000378:metabolism; D005416:Flavivirus / Q000276:immunology / Q000502:physiology*; D054884:Host-Pathogen Interactions; D011487:Protein Conformation; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000956:Antigens, Viral; D014764:Viral Proteins
keywords: Antibody-mediated neutralization; Dengue virus; Flavivirus; Structural dynamics; Viral breathing; West Nile virus
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