title: Macular structure-function relationship at various spatial locations in glaucoma.
abstract: OBJECTIVE
  To study whether the structure-function (S-F) relationship in glaucoma differs according to macular location using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry 10-2 and 24-2 visual fields (VFs).
  
  
  METHODS
  We enrolled 151 eyes of 151 healthy, preperimetric and perimetric glaucomatous subjects. Macular ganglion cell-inner plexiform layer thicknesses at different parafoveal locations were measured using Cirrus SD-OCT. The mean sensitivity of 10-2 and 24-2 VFs was recorded in the decibel and 1/L scales. The topographic relationships between structure and function were assessed at different parafoveal and hemimacular locations using 'weighted' correlation coefficients. The strength of S-F relationships between macular ganglion cell-inner plexiform layer thickness measurements and VF mean sensitivity in various parafoveal locations and in superior and inferior hemimacula was compared using Steiger's test.
  
  
  RESULTS
  The temporal parafoveal sector showed a significantly greater S-F relationship in each hemimacula compared with other parafoveal sectors (p<0.05). The inferior hemimacula showed a significantly greater S-F relationship than superior hemimacula (p<0.001).
  
  
  CONCLUSIONS
  The strength of the S-F associations at the temporal parafoveal location is significantly greater than that of the central or nasal parafoveal location in each hemimacula. The strength of the S-F association is significantly greater in the inferior hemimacula than in the superior hemimacula.
authors.affiliation: Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Soa
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Seon-Ok
authors.initials: SO
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kook
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008266:Macula Lutea / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields
keywords: Field of vision; Glaucoma; Macula