title: Surgery and survival outcomes of 30 patients with neurological deficit due to clear cell renal cell carcinoma spinal metastases.
abstract: OBJECTIVE
  The aim of this study was to provide some useful insights into the clinical and imaging presentations, treatment and prognostic factors in patients with neurological deficit caused by clear cell renal cell carcinoma (CCRCC) spinal metastases for the sake of designing individualized therapeutic plans for such patients.
  
  
  METHODS
  A total of 30 patients with neurological deficit due to CCRCC spinal metastases who received surgery in our department were identified during an 8-year period from 2003 to 2012 and used for discussion of treatment options for CCRCC spinal metastases on the basis of literature review and our own experience.
  
  
  RESULTS
  Univariate analysis showed that age (≤45 years/>45 years), visceral metastasis, Tomita score (3-5/6-8), Tokuhashi score (4-9/10-12) and radiotherapy were suggested as the potential prognostic factors. However, the multivariate Cox regression model showed that only Tokuhashi score was an independent prognostic factor.
  
  
  CONCLUSIONS
  Tokuhashi score 10 or more is a favorable prognostic factor of CCRCC spinal metastasis.
authors.affiliation: Department of Bone Tumor Surgery, Spine Tumor Center, Changzheng Hospital, Second Military Medical University, Fengyang Rd 415#, Huangpu District, Shanghai, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Han
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.forename: Dongjie
authors.initials: D
authors.lastname: Jiang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Wangjun
authors.initials: W
authors.lastname: Yan
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.forename: Wang
authors.initials: W
authors.lastname: Zhou
authors.forename: Jianru
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000556:secondary* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D009422:Nervous System Diseases / Q000209:etiology*; D011379:Prognosis; D012720:Severity of Illness Index; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome
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