title: Dietary supplement use among cancer survivors of the NutriNet-Santé cohort study.
abstract: Dietary supplements (DS) may influence cancer prognosis. Their use in cancer patients has been described in the United States, but data are largely lacking in Europe and notably in France. The present study's objectives were (1) to assess DS use and its sociodemographic, lifestyle, and dietary correlates in a large sample of French cancer survivors; (2) to evaluate the involvement of physicians in such DS use; and (3) to assess the extent of potentially harmful practices. Data were collected by self-administered web-based questionnaires among participants of the NutriNet-Santé cohort. Data on DS use was available for 1081 cancer survivors. DS users were compared to non-users with unconditional logistic regressions. DS use was reported by 62% of women and 29% of men. Vitamins D, B6, C and Mg were the most frequently consumed nutrients. 14% of cancer survivors initiated DS use after diagnosis. For 35% of the DS consumed, subjects did not inform their attending physician. DS use was associated with a healthier lifestyle (normal weight, never smoking and better diet) and substantially contributed to nutrient intake. 18% of DS users had potentially harmful DS use practices, such as the simultaneous use of vitamin E and anticoagulant/antiplatelet agents, the use of β-carotene and smoking or the use of phyto-oestrogens in hormone-dependent cancer patients. The present study suggests that DS use is widespread among cancer survivors, a large amount of that use is performed without any medical supervision and a substantial proportion of that use involves potentially harmful practices. Physicians should be encouraged to more routinely discuss DS use with their cancer patients.
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Camille
authors.initials: C
authors.lastname: Pouchieu
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Philippine
authors.initials: P
authors.lastname: Fassier
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Druesne-Pecollo
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Zelek
authors.affiliation: Cancer, Environment and Nutrition Unit, Anticancer Centre Léon-Bérard,Lyon,France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Bachmann
authors.affiliation: Cancer, Environment and Nutrition Unit, Anticancer Centre Léon-Bérard,Lyon,France.
authors.forename: Marina
authors.initials: M
authors.lastname: Touillaud
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bairati
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.affiliation: DySoLa, EA 4701, Rouen University,Rouen,France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Cohen
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Paule
authors.initials: P
authors.lastname: Latino-Martel
authors.affiliation: Sorbonne Paris Cité, Epidemiology and Biostatistics Research Centre, Nutritional Epidemiology Research Team (EREN), Inserm U1153, Inra U1125, Cnam, Paris 13, 7 and 5 Universities,Bobigny,France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Touvier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D005602:France; D006801:Humans; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D011379:Prognosis; D011795:Surveys and Questionnaires; D017741:Survivors; D014810:Vitamin E / Q000378:metabolism; D055815:Young Adult; D019207:beta Carotene
chemical_list: D019207:beta Carotene; D014810:Vitamin E
keywords: Cancer survivors