title: [Accumulation of p53 protein and overexpression of the HER3 receptor in colorectal cancer].
abstract: In patients with colorectal cancer, nuclear accumulation of p53 is often associated with poor prognosis and resistance to chemotherapy. Overexpression of HER3 is associated with poor prognosis and resistance to therapy targeting EGFR. Our study was performed on 16 samples of colorectal adenocarcinomas. The pieces fixed in formalin were embedded in paraffin. The study of the expression of p53 and HER3 is performed by immunohistochemical technique. Immunohistochemical study of the expression of p53 showed nuclear accumulation of this protein in 87% of colorectal adenocarcinomas analyzed. Regarding the HER3 receptor overexpression was observed in 56% of cases. Overall, 50% of the cases co-expressed p53 and HER3. HER3 and p53 are important markers of colorectal cancer because they provide information about the distinctive biological characteristics of tumors. The prognostic and predictive value of the combination of these two markers could be an important clinical tool.
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc.
authors.forename: Siham
authors.initials: S
authors.lastname: Amsaguine
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc.
authors.forename: Sara
authors.initials: S
authors.lastname: El Mhaia
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc, Service de chirurgie, Centre hospitalier Ibn Sina, Rabat, Maroc.
authors.forename: Houda
authors.initials: H
authors.lastname: Drissi
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc.
authors.forename: Chrifa
authors.initials: C
authors.lastname: Amer
authors.affiliation: Service de chirurgie, Centre hospitalier Ibn Sina, Rabat, Maroc.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ahallat
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc.
authors.forename: Najat
authors.initials: N
authors.lastname: El Amrani
authors.affiliation: Equipe « Signalisations cellulaires et pathologies associées », Laboratoire biologie et santé, URAC 34, Université Hassan II, Faculté des sciences Ben M'sik, Casablanca, Maroc.
authors.forename: Driss
authors.initials: D
authors.lastname: Radallah
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D011237:Predictive Value of Tests; D011379:Prognosis; D020893:Receptor, ErbB-3 / Q000378:metabolism*; D014018:Tissue Distribution; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D016159:Tumor Suppressor Protein p53; C581292:ERBB3 protein, human; D020893:Receptor, ErbB-3
keywords: HER3 receptor; colorectal cancer; immunohistochemistry; p53; prognostic value; tumor markers