title: p53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease.
abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with a selective loss of dopamine (DA) neurons in the substantia nigra of the midbrain. Recently, it has been demonstrated that acupuncture treatment has protective effects in PD. However, to date, the molecular mechanisms underlying acupuncture's effect on DA neuronal protection are largely unknown. In this study, we report that p53 signalling mediates the protective effects of acupuncture treatment in a mouse model of PD. We found that the acupuncture treatment in the mouse PD model results in significant recovery to the normal in the context of behaviour and molecular signatures. We found that the gene network associated with p53 signalling is closely involved in the protective effects of acupuncture treatment in PD. Consistent with this idea, we demonstrated that specific knockout of the p53 gene in the midbrain DA neurons abrogates the acupuncture induced protective effects in the mouse model of PD. Thus, these data suggest that p53 signalling mediates the protective effects of acupuncture treatment in PD.
authors.affiliation: Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
authors.forename: Ji-Yeun
authors.initials: JY
authors.lastname: Park
authors.affiliation: Department of Biomedical Engineering, Dongguk University, 3-ga, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea.
authors.forename: Hwan
authors.initials: H
authors.lastname: Choi
authors.affiliation: Department of Biomedical Engineering, Dongguk University, 3-ga, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea.
authors.forename: Soonbong
authors.initials: S
authors.lastname: Baek
authors.affiliation: Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea; Department of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
authors.forename: Jaehwan
authors.initials: J
authors.lastname: Jang
authors.affiliation: Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea; Department of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea.
authors.forename: Ahreum
authors.initials: A
authors.lastname: Lee
authors.affiliation: Dongguk University Research Institute of Biotechnology, 3-ga, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea. Electronic address: Jsong0304@hanmail.net.
authors.forename: Songhee
authors.initials: S
authors.lastname: Jeon
authors.affiliation: Department of Biomedical Engineering, Dongguk University, 3-ga, Pil-dong, Chung-gu, Seoul 100-715, Republic of Korea. Electronic address: jk2316@gmail.com.
authors.forename: Jongpil
authors.initials: J
authors.lastname: Kim
authors.affiliation: Studies of Translational Acupuncture Research (STAR), Acupuncture & Meridian Science Research Center (AMSRC), Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea; Department of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemoon-gu, Seoul 130-701, Republic of Korea. Electronic address: acufind@khu.ac.kr.
authors.forename: Hi-Joon
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53
keywords: Acupuncture; Mechanism; Parkinson's disease