title: Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: a rare case.
abstract: A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 10(9)/L, 3.4% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of "chronic eosinophilic leukemia, not otherwise specified" (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.
authors.affiliation: Unit of Pediatric Hematology, Dr. A. Y. Ankara Oncology Research and Training Hospital, Ankara, Turkey. laleolcay@hotmail.com.tr.
authors.forename: Meriç
authors.initials: M
authors.lastname: Kaymak-Cihan
authors.forename: Ajlan
authors.initials: A
authors.lastname: Tükün
authors.forename: Barış
authors.initials: B
authors.lastname: Kuşkonmaz
authors.forename: Bilgin
authors.initials: B
authors.lastname: Arıbaş
authors.forename: Işınsu
authors.initials: I
authors.lastname: Kuzu
authors.forename: Serpil
authors.initials: S
authors.lastname: Dizbay-Sak
authors.forename: Nazire
authors.initials: N
authors.lastname: Terzi
authors.forename: Ayşenur
authors.initials: A
authors.lastname: Paç
authors.forename: Nural
authors.initials: N
authors.lastname: Kiper
authors.forename: Macit
authors.initials: M
authors.lastname: Arıyürek
authors.forename: Lale
authors.initials: L
authors.lastname: Olcay
mesh_terms: D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000628:therapy; D007938:Leukemia; D007958:Leukocyte Count; D008775:Methylprednisolone / Q000627:therapeutic use*; D009006:Monosomy
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone