title: Microfluidic generation of PEG-b-PLA polymersomes containing alginate-based core hydrogel.
abstract: Herein, we demonstrate a novel method for the generation of monodisperse cell-like structures containing a biocompatible hydrogel matrix surrounded by a membrane responsive to chemical cues. Specifically, we employ droplet-based microfluidics to generate PEG-PLA polymersomes encapsulating alginate in liquid form. We investigate alginate core gelation by creating an osmotic pressure gradient across the polymeric membrane that, through expansion, allows the passage of calcium ions. The effects of calcium concentration on the core gelation are explored.
authors.affiliation: Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering , ETH Zurich, Vladimir Prelog Weg 1, Zürich 8093, Switzerland.
authors.forename: Chiara
authors.identifier: 0000-0003-1887-9853
authors.initials: C
authors.lastname: Martino
authors.affiliation: Department of Chemical and Biomolecular Engineering, KAIST , Daejeon, South Korea.
authors.forename: Tae Yong
authors.initials: TY
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biomolecular Engineering, KAIST , Daejeon, South Korea.
authors.forename: Shin-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering , ETH Zurich, Vladimir Prelog Weg 1, Zürich 8093, Switzerland.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: deMello
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