title: Angiotensins as therapeutic targets beyond heart disease.
abstract: The renin-angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating hypertension and related cardiovascular diseases is well established. However, actions of the RAS go far beyond the targets initially described. In this regard, the recent identification of novel components of the RAS, including angiotensin-(1-7) [Ang-(1-7)], Ang-(1-9), and alamandine, have opened new possibilities for interfering with the development and manifestations of cardiovascular and non-cardiovascular diseases. In this article, we briefly review novel targets for angiotensins and its therapeutic implications in diverse areas, including cancer, inflammation, and glaucoma.
authors.affiliation: National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Danielle Gomes
authors.initials: DG
authors.lastname: Passos-Silva
authors.affiliation: Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile.
authors.forename: Enrique
authors.initials: E
authors.lastname: Brandan
authors.affiliation: National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Instituto de Cardiologia do Rio Grande do Sul/Fundação Universitária de Cardiologia, 395 Avenida Princesa Isabel, Porto Alegre, Rio Grande do Sul, 90620-001, Brazil. Electronic address: robsonsant@gmail.com.
authors.forename: Robson Augusto Souza
authors.initials: RA
authors.lastname: Santos
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000378:metabolism; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism; D006331:Heart Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D011658:Pulmonary Fibrosis / Q000188:drug therapy* / Q000378:metabolism; D012084:Renin-Angiotensin System
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors
keywords: Mas receptor; angiotensin II; angiotensin-(1–7); cancer; renin–angiotensin system