title: Cerebral involvement in IgG4-related disease.
abstract: IgG4-related disease is a recently recognised multi-system disease. Common organ involvement includes the pancreas, biliary tree and salivary glands. Central nervous system involvement has been infrequently reported. In a single-centre cohort of 84 patients, we report cerebral involvement in three (4%) patients. Details of cerebral involvement in these patients are outlined, including pituitary involvement in two patients and a diffuse autoimmune-like encephalopathy in the other.
authors.affiliation: Department of Gastroenterology, University College London Hospitals, London, UK;
authors.forename: Deepak
authors.initials: D
authors.lastname: Joshi
authors.affiliation: Department of Radiology, University College London Hospitals, London, UK;
authors.forename: Rolf
authors.initials: R
authors.lastname: Jager
authors.affiliation: Department of Endocrinology, University College London Hospitals, London, UK;
authors.forename: Steven
authors.initials: S
authors.lastname: Hurel
authors.affiliation: Department of Gastroenterology, University College London Hospitals, London, UK;
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
authors.affiliation: Department of Gastroenterology, University College London Hospitals, London, UK;
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Johnson
authors.affiliation: Department of Gastroenterology, University College London Hospitals, London, UK;
authors.forename: Michael
authors.initials: M
authors.lastname: Chapman
authors.affiliation: Department of Respiratory Medicine, Barking, Havering and Redbridge University Hospitals, UK;
authors.forename: Robert
authors.initials: R
authors.lastname: Fowler
authors.affiliation: Department of Pathology, University College London Hospitals, London, UK;
authors.forename: Alison
authors.initials: A
authors.lastname: Winstanley
authors.affiliation: The National Hospital for Neurology and Neurosurgery, London, UK;
authors.forename: Nicholas
authors.initials: N
authors.lastname: Losseff
authors.affiliation: Department of Gastroenterology, University College London Hospitals, London, UK george.webster@uclh.nhs.uk.
authors.forename: George Jm
authors.initials: GJ
authors.lastname: Webster
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
chemical_list: D007074:Immunoglobulin G
keywords: Autoimmune pancreatitis; IgG4-related disease; encephalopathy; hypophysitis
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