title: Risk factors for cytarabine-induced cutaneous toxicity in patients with haematological malignancies.
abstract: BACKGROUND
  The risk factors for cytarabine (Ara-C)-induced cutaneous toxicity are unclear.
  
  
  METHODS
  We retrospectively reviewed the medical charts of patients with haematopoietic malignancies treated with Ara-C and examined risk factors for Ara-C-induced cutaneous toxicity.
  
  
  RESULTS
  We reviewed 114 patients (76 men, 38 women) and found that 47 patients (41.2%) experienced cutaneous toxicity. In 93 patients (81.6%) with non-Hodgkin's lymphoma (NHL) and acute myeloid leukaemia (AML), the toxicity was significantly associated with the cancer type [AML/NHL: odds ratio (OR) = 4.84; 95% confidence interval (CI) = 1.99-11.81; p = 0.001], age (<50/≥50 years: OR = 2.54; 95% CI = 1.08-5.95; p = 0.032) and concurrent steroid administration (yes/no: OR = 0.22; 95% CI = 0.09-0.56; p = 0.001). AML was the only significant association (OR = 3.83; 95% CI = 1.21-12.06; p = 0.022) in the multivariate logistic analysis.
  
  
  CONCLUSIONS
  AML, age <50 years and no steroid use are considered to be risk factors for Ara-C-induced cutaneous toxicity.
authors.affiliation: Department of Clinical Pharmacy and Education, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
authors.forename: Kayoko
authors.initials: K
authors.lastname: Morio
authors.forename: Masao
authors.initials: M
authors.lastname: Mizuki
authors.forename: Takashi
authors.initials: T
authors.lastname: Sozu
authors.forename: Etsuko
authors.initials: E
authors.lastname: Uejima
mesh_terms: D003561:Cytarabine / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012871:Skin Diseases / Q000139:chemically induced*
chemical_list: D003561:Cytarabine