title: Royal Jelly and its dual role in TNBS colitis in mice.
abstract: Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil ; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Luis Paulo
authors.initials: LP
authors.lastname: Manzo
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil ; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Felipe Meira
authors.initials: FM
authors.lastname: de-Faria
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Ricardo José
authors.initials: RJ
authors.lastname: Dunder
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Eduardo Augusto
authors.initials: EA
authors.lastname: Rabelo-Socca
authors.affiliation: Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Silvio Roberto
authors.initials: SR
authors.lastname: Consonni
authors.affiliation: Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Ana Cristina Alves
authors.initials: AC
authors.lastname: de Almeida
authors.affiliation: Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil ; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, Brazil.
authors.forename: Alba Regina Monteiro
authors.initials: AR
authors.lastname: Souza-Brito
authors.affiliation: Department of Biological Sciences, Federal University of Goiás (UFG), Regional Catalão, 75704-020 Catalão, GO, Brazil.
authors.forename: Anderson
authors.initials: A
authors.lastname: Luiz-Ferreira
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D003092:Colitis / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D055951:Functional Food; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity; D000099219:Royal Jelly
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D051546:Cyclooxygenase 2; D005227:Fatty Acids; D005978:Glutathione; D005979:Glutathione Peroxidase; D016328:NF-kappa B; D014302:Trinitrobenzenesulfonic Acid; D000099219:Royal Jelly; C077623:Ptgs2 protein, mouse
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