title: Retinoic acid and glycolic acid combination in the treatment of acne scars.
abstract: BACKGROUND
  Acne is a prevalent condition in society affecting nearly 80-90% of adolescents often resulting in secondary damage in the form of scarring. Retinoic acid (RA) is said to improve acne scars and reduce postinflammatory hyperpigmentation while glycolic acid (GA) is known for its keratolytic properties and its ability to reduce atrophic acne scars. There are studies exploring the combined effect of retinaldehyde and GA combination with positive results while the efficacy of retinoic acid and GA (RAGA) combination remains unexplored.
  
  
  OBJECTIVE
  The aim of this study remains to retrospectively assess the efficacy of RAGA combination on acne scars in patients previously treated for active acne.
  
  
  METHODS
  A retrospective assessment of 35 patients using topical RAGA combination on acne scars was done. The subjects were 17-34 years old and previously treated for active acne. Case records and photographs of each patient were assessed and the acne scars were graded as per Goodman and Baron's global scarring grading system (GSGS), before the start and after 12 weeks of RAGA treatment. The differences in the scar grades were noted to assess the improvement.
  
  
  RESULTS
  At the end of 12 weeks, significant improvement in acne scars was noticed in 91.4% of the patients.
  
  
  CONCLUSIONS
  The RAGA combination shows efficacy in treating acne scars in the majority of patients, minimizing the need of procedural treatment for acne scars.
authors.affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Chandrashekar
authors.affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
authors.forename: K R
authors.initials: KR
authors.lastname: Ashwini
authors.affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
authors.forename: Vani
authors.initials: V
authors.lastname: Vasanth
authors.affiliation: Department of Dermatology, CUTIS, Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.
authors.forename: Shreya
authors.initials: S
authors.lastname: Navale
keywords: Acne scars; glycolic acid; retinoic acid; retinoic acid and glycolic acid
references.citation: J Eur Acad Dermatol Venereol. 2011 Apr;25(4):398-402
references.pmid: 21371128
references.citation: Dermatology. 2007;214(3):260-7
references.pmid: 17377389
references.citation: J Cosmet Dermatol. 2006 Mar;5(1):48-52
references.pmid: 17173571
references.citation: Dermatol Res Pract. 2010;2010:893080
references.pmid: 20981308
references.citation: J Am Acad Dermatol. 2008 Oct;59(4):659-76
references.pmid: 18662839
references.citation: Dermatol Surg. 2006 Dec;32(12):1458-66
references.pmid: 17199653
references.citation: Int J Dermatol. 2000 Oct;39(10 ):789-94
references.pmid: 11095203
references.citation: J Am Acad Dermatol. 1984 Nov;11(5 Pt 1):867-79
references.pmid: 6096420
references.citation: J Invest Dermatol. 1991 Jun;96(6):975-8
references.pmid: 2045685
references.citation: Cutis. 1989 Mar;43(3):222-8
references.pmid: 2523288
references.citation: Int J Dermatol. 1999 Feb;38(2):149-53
references.pmid: 10192170
references.citation: Clin Cosmet Investig Dermatol. 2013 Nov 11;6:281-8
references.pmid: 24399880