title: Cholecystectomy does not significantly increase the risk of fatty liver disease.
abstract: OBJECTIVE
  To investigate the relationship between cholecystectomy and fatty liver disease (FLD) in a Chinese population.
  
  
  METHODS
  A total of 32428 subjects who had voluntarily undergone annual health checkups in the Second Affiliated Hospital of Nanjing Medical University from January 2011 to May 2013 were included in this study. Basic data collection, physical examination, laboratory examination, and abdominal ultrasound examination were performed.
  
  
  RESULTS
  Subjects undergoing cholecystectomy were associated with greater age, female sex, higher body mass index, and higher levels of systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, and triglycerides. However, no significant differences were found in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, albumin, and serum uric acid. The overall prevalence of FLD diagnosed by ultrasonography was high at 38.4%. The prevalence of FLD was significantly higher for subjects who had undergone cholecystectomy (46.9%) than those who had not undergone cholecystectomy (38.1%; χ(2) test, P < 0.001). Cholecystectomy was positively associated with FLD (OR = 1.433, 95%CI: 1.259-1.631). However, after adjusting for possible factors associated with FLD, multivariate regression analysis showed that the association between cholecystectomy and FLD was not statistically significant (OR = 1.096; 95%CI: 0.939-1.279).
  
  
  CONCLUSIONS
  According to our study results, cholecystectomy may not be a significant risk factor for FLD.
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Hong-Gang
authors.initials: HG
authors.lastname: Wang
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Li-Zhen
authors.initials: LZ
authors.lastname: Wang
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Hang-Jiang
authors.initials: HJ
authors.lastname: Fu
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shen
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Huang
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Zhang
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Xie
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Xiao-Zhong
authors.initials: XZ
authors.lastname: Yang
authors.affiliation: Hong-Gang Wang, Peng Shen, Rui Xie, Xiao-Zhong Yang, Department of Gastroenterology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an 223300, Jiangsu Province, China.
authors.forename: Guo-Zhong
authors.initials: GZ
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D002763:Cholecystectomy / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Cholecystectomy; Cross-sectional study; Fatty liver disease; Relationship
references.citation: J Dig Dis. 2011 Feb;12(1):1-2
references.pmid: 21091929
references.citation: Am J Gastroenterol. 2010 Jan;105(1):14-32; quiz 33
references.pmid: 19904248
references.citation: Gut. 2012 Mar;61(3):409-15
references.pmid: 21846782
references.citation: Hepatology. 2012 Jun;55(6):2005-23
references.pmid: 22488764
references.citation: Am J Gastroenterol. 2013 Jun;108(6):952-8
references.pmid: 23545713
references.citation: Am J Gastroenterol. 2010 Jun;105(6):1364-73
references.pmid: 20068558
references.citation: Liver Int. 2011 Jan;31(1):52-64
references.pmid: 21040411
references.citation: N Engl J Med. 2002 Apr 18;346(16):1221-31
references.pmid: 11961152
references.citation: Hepatology. 2003 May;37(5):1202-19
references.pmid: 12717402
references.citation: N Engl J Med. 1973 Dec 6;289(23):1213-6
references.pmid: 4748594
references.citation: J Clin Invest. 1977 May;59(5):828-40
references.pmid: 856870
references.citation: Gut. 1978 Jul;19(7):640-9
references.pmid: 567165
references.citation: Hepatology. 1995 Jan;21(1):41-5
references.pmid: 7806167
references.citation: Lancet. 2005 Apr 16-22;365(9468):1398-405
references.pmid: 15836888
references.citation: J Hepatol. 2005 Sep;43(3):508-14
references.pmid: 16006003
references.citation: World J Gastroenterol. 2007 Mar 14;13(10):1579-84
references.pmid: 17461452
references.citation: World J Gastroenterol. 2007 Dec 21;13(47):6419-24
references.pmid: 18081233
references.citation: Hepatobiliary Pancreat Dis Int. 2009 Aug;8(4):377-82
references.pmid: 19666406
references.citation: Hepatology. 2012 Feb;55(2):575-83
references.pmid: 21953282