title: Primitive neuroectodermal tumor of the kidney in a young male: Case report and review of literature.
abstract: Primitive neuroectodermal tumor of the kidney is a rare tumor. A total of approximately 79 primary renal cases have been reported to date. Primitive neuroectodermal tumors occur preferentially in the soft-tissues of the paravertebral region and chest wall, less frequently in extremities, with a slight male predominance. We report a case of primitive neuroectodermal tumor of the kidney in a 17-year-old male with a pre-operative diagnosis of renal cell carcinoma-stage 4. The patient underwent radical nephrectomy and histopathological examination revealed a highly aggressive tumor of monotonous sheets of round cells with focal areas of rosette formations and high mitotic rate with Ki67 index of 25-30%. Tumor cells were positive for CD 99 confirming the diagnosis of primitive neuroectodermal tumor. Primitive neuroectodermal tumor of the kidney needs to be kept in mind as a differential diagnosis in young adults presenting with a large kidney mass.
authors.affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Nivedita
authors.initials: N
authors.lastname: Patnaik
authors.affiliation: Department of Pathology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Mishra
authors.affiliation: Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Saini
authors.affiliation: Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India.
authors.forename: Nitin
authors.initials: N
authors.lastname: Agarwal
keywords: Blastemal wilms; immunohistochemistry; kidney; primitive neuroectodermal tumor
references.citation: Med Pediatr Oncol. 1994;23(5):437-40
references.pmid: 8084311
references.citation: Am J Surg Pathol. 2005 Aug;29(8):1025-33
references.pmid: 16006796
references.citation: Pathol Res Pract. 2002;198(8):563-9
references.pmid: 12390000
references.citation: Rare Tumors. 2012 Jan 2;4(1):e15
references.pmid: 22532913
references.citation: Mod Pathol. 2004 May;17(5):547-52
references.pmid: 15001993
references.citation: Histopathology. 1990 May;16(5):461-7
references.pmid: 2163356
references.citation: Hum Pathol. 2007 Feb;38(2):205-11
references.pmid: 17134738