title: Plasma BDNFs level initially and post treatment in acute mania: comparison between ECT and atypical antipsychotic treatment and healthy controls.
abstract: BACKGROUND
  Inconsistent findings concerning brain-derived neurotrophic factor (BDNF) levels across different episodes in bipolar disorder have been reported, which is also in line with the treatment effects on BDNF levels in acute mania. We aimed to compare plasma BDNF level alterations after pure antipsychotic drug or ECT plus antipsychotic drug treatment in acute mania.
  
  
  METHODS
  Sixty-eight patients with mania were divided into two treatment arms: the antipsychotic treatment arm (AP) and electroconvulsive therapy (ECT)+AP arm. In addition, 30 healthy controls were included in the study.
  
  
  RESULTS
  There was no significant statistical difference according to mean age, education level, marital and working status between patients and healthy controls. The initial serum BDNF level in patients with acute mania was significantly lower than healthy controls. The initial BDNF level between the ECT arm and AP arm was not significant. The BDNF level decreased significantly after reaching remission in patients with acute mania. The change in BDNF level in the AP arm was not significant while in the ECT arm it was significant after treatment.
  
  
  CONCLUSIONS
  In this study, for the first time we revealed a significant decrease in BDNF levels after ECT sessions in acute manic patients. Besides clinical remission after treatment in acute mania, the decrement in BDNF levels does not seem to be related to clinical response. Thus cumulative effects of mood episodes for the ongoing decrease in BDNF levels might be borne in mind despite the achievement of remission and/or more time being required for an increase in BDNF levels after treatment.
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Karamustafalioglu
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Genc
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Tevfik
authors.initials: T
authors.lastname: Kalelioglu
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey akiftasdemir@mail.com.
authors.forename: Akif
authors.initials: A
authors.lastname: Tasdemir
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Umut
authors.affiliation: Department of Biochemistry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey.
authors.forename: Said
authors.initials: S
authors.lastname: Incir
authors.affiliation: Department of Psychiatry, Bakırkoy Mental Health Research and Training State Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akkuş
authors.affiliation: Department of Psychiatry, Medical School of Cerrahpasa, Istanbul University, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Emul
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy / Q000628:therapy*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D004565:Electroconvulsive Therapy / Q000379:methods*; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008297:Male; D017063:Outcome Assessment, Health Care; D000069348:Quetiapine Fumarate / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D000069348:Quetiapine Fumarate; C579455:BDNF protein, human; D006220:Haloperidol
keywords: Brain derived neurotropic factor; atypical antipsychotics; electroconvulsive therapy (ECT); mania