title: The cost of liver disease in Korea: methodology, data, and evidence.
abstract: OBJECTIVE
  This study introduces methods for estimating the cost of liver disease and presents useful and reliable sources of data. The available evidence on the costs associated with liver disease is also discussed.
  
  
  METHODS
  Costing methodology can be used to identify, measure, and value relevant resources incurred during the care of patients with liver diseases. It adjusts for discounting, skewed distribution, and missing or censored cost data. The human capital approach for productivity cost assumes that deceased patients would have lived to a normal expected life expectancy, and have earned a salary in line with the current age profile of wages, in order to measure potential earnings lost due to premature death or job loss.
  
  
  METHODS
  The number of deaths due to liver cancer (C22) increased from 6,384 in 1983 to 11,405 in 2013, while deaths due to other liver diseases (K70-K76) increased from 12,563 in 1983 to 13,458 in 1995, and then declined to 6,665 in 2013. According to the Global Burden of Disease study conducted by the World Health Organization, liver cancer caused 325,815 disability-adjusted life years (DALYs), and cirrhosis of the liver caused 206,917 DALYs in 2012. The total cost of liver disease was estimated at 1,941 billion Korean won in 2001 and 5,689 billion Korean won in 2008. Much of this cost is attributable to productivity cost, and especially that of economically active men.
  
  
  CONCLUSIONS
  The economic burden of liver disease is immense because of the associated high mortality and morbidity, especially among the economically active population. This indicates the need to prioritize the development of appropriate health interventions.
authors.affiliation: Healthcare Management, School of Business, Hallym University, Chuncheon, Korea.
authors.forename: Wankyo
authors.initials: W
authors.lastname: Chung
mesh_terms: D017281:Cost of Illness; D006801:Humans; D008107:Liver Diseases / Q000191:economics* / Q000453:epidemiology / Q000401:mortality; D008113:Liver Neoplasms / Q000191:economics* / Q000453:epidemiology / Q000401:mortality; D056910:Republic of Korea / Q000453:epidemiology
keywords: Cost of illness; Liver disease
references.citation: Korean J Hepatol. 2011 Dec;17(4):274-91
references.pmid: 22310792
references.citation: Health Econ. 2010 Mar;19(3):316-33
references.pmid: 19378353
references.citation: Lancet. 2012 Dec 15;380(9859):2163-96
references.pmid: 23245607
references.citation: Lancet. 2012 Dec 15;380(9859):2063-6
references.pmid: 23245602
references.citation: Hepatology. 2002 Jul;36(1):227-42
references.pmid: 12085369