title: Mechanistic overview of ADP-ribosylation reactions.
abstract: ADP-ribosylation reactions consist of mono-ADP-ribosylation, poly-ADP-ribosylation and cyclic ADP-ribosylation. These reactions play essential roles in many important physiological and pathophysiological events. The types of chemical linkages, the evolutionarily conserved motif within the enzymes to determine the target specificity, stereochemistry of the ADP-ribosylated products, and the chemical reactions taking place among the enzymes and substrates are discussed.
authors.affiliation: Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Harvard University, MA 02115, USA. Electronic address: mvsung@gmail.com.
authors.forename: Vicky M-H
authors.initials: VM
authors.lastname: Sung
mesh_terms: D036002:ADP Ribose Transferases / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D006801:Humans
chemical_list: D000246:Adenosine Diphosphate Ribose; D036002:ADP Ribose Transferases
keywords: ADP-ribosylation; Cyclic ADP-ribosylation; Mono-ADP-ribosylation; NAD(+); Poly-ADP-ribosylation; Schiff base