title: Effect of da-cheng-qi decoction on pancreatitis-associated intestinal dysmotility in patients and in rat models.
abstract: The impairment of intestinal motility and related infectious complications are the predominant clinical phenomenon in patients with severe acute pancreatitis (SAP). We aimed to investigate the effects of Da-Cheng-Qi decoction (DCQD) on the gastrointestinal injury in SAP patients and the potential mechanism involved in rats. DCQD was enema administered to 70 patients for 7 days in West China Hospital. Mortality and organ failure during admission were observed and blood samples for laboratory analysis were collected. We also experimentally examined plasma inflammatory cytokines in rat serum and carried the morphometric studies of the gut. Intestinal propulsion index and serum and tissue vasoactive intestinal peptide (VIP) were also detected. Though DCQD did not affect the overall incidence of organ failure, it shortened the average time of paralytic intestinal obstruction and decreased the morbidity of infectious complications in patients with SAP. Compared with untreated rats, the DCQD lowered the levels of proinflammatory cytokine and decreased the mean pathological intestinal lesion scores. The VIP level in intestinal tissue or serum in DCQD group was obviously lowered and intestinal propulsion index was significantly improved. In conclusion, DCQD has good effect on pancreatitis-associated intestinal dysmotility in patients and in rat models.
authors.affiliation: Department of Pharmacology, School of Preclinical and Forensic Medicine, West China Medical Center, Sichuan University, Chengdu 610041, China.
authors.forename: Jianlei
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Cejun
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Guangyuan
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Wenfu
authors.initials: W
authors.lastname: Tang
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G8-15
references.pmid: 12065286
references.citation: Neurogastroenterol Motil. 2005 Oct;17(5):671-9
references.pmid: 16185305
references.citation: J Surg Res. 1995 Aug;59(2):271-8
references.pmid: 7637343
references.citation: World J Surg. 1988 Apr;12(2):255-62
references.pmid: 3394351
references.citation: J Hepatobiliary Pancreat Surg. 2002;9(4):411-2
references.pmid: 12483261
references.citation: Yakushigaku Zasshi. 2002;37(1):28-35
references.pmid: 12408167
references.citation: Dig Dis Sci. 2001 May;46(5):1127-32
references.pmid: 11341659
references.citation: Lancet. 2008 Feb 23;371(9613):651-9
references.pmid: 18279948
references.citation: J Gastroenterol Hepatol. 2003 Jan;18(1):57-62
references.pmid: 12519225
references.citation: Arch Histol Cytol. 2000 Oct;63(4):357-68
references.pmid: 11073067
references.citation: J Gastroenterol Hepatol. 2009 May;24(5):743-7
references.pmid: 19220667
references.citation: Gastroenterology. 2004 Apr;126(4):997-1004
references.pmid: 15057739
references.citation: World J Gastroenterol. 2014 Dec 7;20(45):16868-80
references.pmid: 25493000
references.citation: Ann Surg. 2007 May;245(5):674-83
references.pmid: 17457158
references.citation: Curr Med Chem. 2006;13(23):2775-87
references.pmid: 17073628
references.citation: Pharm Biol. 2011 Oct;49(10):1058-64
references.pmid: 21595575
references.citation: Surg Gynecol Obstet. 1974 Jul;139(1):69-81
references.pmid: 4834279
references.citation: Clin Cancer Res. 2004 Dec 15;10(24):8235-42
references.pmid: 15623599
references.citation: Gut. 2005 Mar;54(3):426-36
references.pmid: 15710995
references.citation: Am J Physiol. 1997 Dec;273(6 Pt 1):G1233-45
references.pmid: 9435548
references.citation: Crit Care Med. 1985 Oct;13(10):818-29
references.pmid: 3928249