title: Enzyme-Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes.
abstract: We describe the design and function of an artificial enzyme-linked receptor (ELR) that can bind different members of the glutathione-S-transferase (GST) enzyme family. The artificial enzyme-enzyme interactions distinctly affect the catalytic activity of the natural enzymes, the biomimetic, or both, enabling the system to discriminate among structurally similar GST isozymes.
authors.affiliation: Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel 76100.
authors.forename: Karuthapandi
authors.initials: K
authors.lastname: Selvakumar
authors.affiliation: Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel 76100.
authors.forename: Leila
authors.initials: L
authors.lastname: Motiei
authors.affiliation: Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel 76100.
authors.forename: David
authors.initials: D
authors.lastname: Margulies
mesh_terms: D055162:Biocatalysis; D005982:Glutathione Transferase / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism*; D007527:Isoenzymes / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase