title: Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.
abstract: BACKGROUND
  Current data concerning maternal paracetamol intake during pregnancy, or intake during infancy and risk of wheezing or asthma in childhood is inconclusive based on epidemiological studies. We have investigated whether there is a causal link between maternal paracetamol intake during pregnancy and lactation and the development of house dust mite (HDM) induced allergic airways disease (AAD) in offspring using a neonatal mouse model.
  
  
  METHODS
  Pregnant mice were administered paracetamol or saline by oral gavage from the day of mating throughout pregnancy and/or lactation. Subsequently, their pups were exposed to intranasal HDM or saline from day 3 of life for up to 6 weeks. Assessments of airway hyper-responsiveness, inflammation and remodelling were made at weaning (3 weeks) and 6 weeks of age.
  
  
  RESULTS
  Maternal paracetamol exposure either during pregnancy and/or lactation did not affect development of AAD in offspring at weaning or at 6 weeks. There were no effects of maternal paracetamol at any time point on airway remodelling or IgE levels.
  
  
  CONCLUSIONS
  Maternal paracetamol did not enhance HDM induced AAD in offspring. Our mechanistic data do not support the hypothesis that prenatal paracetamol exposure increases the risk of childhood asthma.
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK Immunology Programme, Centre for Life Sciences, National University of Singapore, Singapore, Singapore.
authors.forename: Debbie C P
authors.initials: DC
authors.lastname: Lee
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Simone A
authors.initials: SA
authors.lastname: Walker
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Byrne
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Gregory
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: James
authors.initials: J
authors.lastname: Buckley
authors.affiliation: Department of Respiratory Paediatrics, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bush
authors.affiliation: Centre for Primary Care and Public Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.
authors.forename: Seif O
authors.initials: SO
authors.lastname: Shaheen
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK Department of Respiratory Paediatrics, Royal Brompton Hospital, and National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Sejal
authors.initials: S
authors.lastname: Saglani
authors.affiliation: Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London, UK.
authors.forename: Clare M
authors.initials: CM
authors.lastname: Lloyd
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D018811:Maternal Exposure; D051379:Mice; D011247:Pregnancy
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
keywords: Allergic lung disease; Asthma; Paediatric asthma
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