title: Follow-up of children exposed to ionising radiation from cardiac catheterisation: the Coccinelle study.
abstract: Cardiac catheterisation has become an essential tool in the diagnosis and treatment of children with a wide variety of congenital and acquired forms of cardiovascular disease. Despite the clear clinical benefit to the patient, radiation exposure from paediatric cardiac catheterisation procedures (CCPs) may be substantial. Given children's greater sensitivity to radiation and the longer life span during which radiation health effects can develop, an epidemiological cohort study, named Coccinelle or 'Ladybird' (French acronym for 'Cohorte sur le risque de cancer après cardiologie interventionnelle pédiatrique'), is carried out in France to evaluate the risks of leukaemia and solid cancers in this population. A total number of 8000 included children are expected. Individual CCP-related doses will be assessed for each child included in the cohort. For each CCP performed, dosimetric parameters (dose-area product, fluoroscopy time and total number of cine frames) are retrieved retrospectively. Organ doses, especially to the lung, the oesophagus and the thyroid, are calculated with PCXMC software. The cohort will be followed up through linkage with French paediatric cancer registries.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France helene.baysson@irsn.fr.
authors.forename: H
authors.initials: H
authors.lastname: Baysson
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France.
authors.forename: B
authors.initials: B
authors.lastname: Nkoumazok
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France.
authors.forename: S
authors.initials: S
authors.lastname: Barnaoui
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Réhel
authors.affiliation: Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Girodon
authors.affiliation: Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Milani
authors.affiliation: Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Boudjemline
authors.affiliation: Centre de Référence Malformations Cardiaques Congénitales Complexes, M3C Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Bonnet
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France.
authors.forename: D
authors.initials: D
authors.lastname: Laurier
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, BP 17, Fontenay aux Roses 92260, France.
authors.forename: M O
authors.initials: MO
authors.lastname: Bernier
mesh_terms: D000293:Adolescent; D006328:Cardiac Catheterization / Q000706:statistics & numerical data*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000706:statistics & numerical data*; D011834:Radiation Monitoring / Q000706:statistics & numerical data; D015641:Radiography, Interventional / Q000706:statistics & numerical data*; D012042:Registries; D012107:Research Design; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors
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