title: Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities.
abstract: BACKGROUND
  While much is known about childhood atopic dermatitis, little is known about persistence of atopic dermatitis into adult life. We report, to our knowledge for the first time, the clinical course of atopic dermatitis in an unselected cohort of adolescents followed into adulthood.
  
  
  METHODS
  The course of atopic dermatitis from adolescence to adulthood was studied prospectively in a cohort of unselected 8th-grade schoolchildren established in 1995 and followed up in 2010 with questionnaire and clinical examination.
  
  
  RESULTS
  The lifetime prevalence of atopic dermatitis was high (34.1%), and a considerable number of adults still suffered from atopic dermatitis evaluated both by questionnaire (17.1%) and clinical examination (10.0%). Persistent atopic dermatitis was found in 50% of those diagnosed in school age, and persistent atopic dermatitis was significantly associated with early onset, childhood allergic rhinitis and hand eczema. A close association was also found with allergic contact dermatitis and increased specific IgE to Malassezia furfur, but not with filaggrin gene defect.
  
  
  CONCLUSIONS
  Persistence of atopic dermatitis in adulthood is common and affects quality of life. Persistent atopic dermatitis is particularly prevalent in those with early onset, allergic rhinitis and hand eczema in childhood. It is important to recognizing atopic dermatitis as a common and disabling disease not only in children but also in adults.
authors.affiliation: Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: C G
authors.initials: CG
authors.lastname: Mortz
authors.affiliation: Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: K E
authors.initials: KE
authors.lastname: Andersen
authors.affiliation: Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Dellgren
authors.affiliation: Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.|OPEN (Odense Patient data Exploratory Network), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Barington
authors.affiliation: Department of Dermatology and Allergy Centre, Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark, Odense, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Bindslev-Jensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001249:Asthma / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D004485:Eczema / Q000453:epidemiology; D005260:Female; D000091344:Filaggrin Proteins; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007381:Intermediate Filament Proteins / Q000235:genetics; D008297:Male; D009154:Mutation; D016017:Odds Ratio; D015995:Prevalence; D011788:Quality of Life; D065631:Rhinitis, Allergic / Q000453:epidemiology; D012307:Risk Factors; D012882:Skin Tests; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins
keywords: atopic dermatitis; incidence; persistence; prevalence; risk factors