title: The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women.
abstract: Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Ines
authors.initials: I
authors.lastname: Mrizak
authors.affiliation: Institute of Animal Physiology and Genetics, Academy of Science,Veveří 97,602 00Brno,Czech Republic.
authors.forename: Omar
authors.initials: O
authors.lastname: Šerý
authors.affiliation: Laboratory of Neurobiology and Molecular Psychiatry, Laboratory of Molecular Physiology, Department of Biochemistry, Faculty of Science, Masaryk University,Kotlářská 2,611 37Brno,Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Plesnik
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Amel
authors.initials: A
authors.lastname: Arfa
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Mariem
authors.initials: M
authors.lastname: Fekih
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Ali
authors.initials: A
authors.lastname: Bouslema
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Monia
authors.initials: M
authors.lastname: Zaouali
authors.affiliation: Department of Physiology and Functional Exploration,Farhat Hached University Hospital,Sousse,Tunisia.
authors.forename: Zouhair
authors.initials: Z
authors.lastname: Tabka
authors.affiliation: Physiologie de la Nutrition et Toxicologie, UMR U866 INSERM/Université de Bourgogne/Agro-Sup,6, Boulevard Gabriel,Dijon21000,France.
authors.forename: Naim Akhtar
authors.initials: NA
authors.lastname: Khan
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000483:Alleles; D018955:CD36 Antigens / Q000235:genetics*; D016000:Cluster Analysis; D004041:Dietary Fats; D005260:Female; D005518:Food Preferences; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D019301:Oleic Acid / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D013649:Taste / Q000235:genetics; D013650:Taste Buds / Q000502:physiology*; D055697:Taste Perception / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D014416:Tunisia
chemical_list: D018955:CD36 Antigens; D004041:Dietary Fats; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D019301:Oleic Acid
keywords: Genes