title: How should we manage a patient with invasive mucoromycosis who develops life-threatening reaction to amphotericin B? Report of two cases and literature review.
abstract: This report presents two cases of invasive rhino-orbital mucormycosis who had life-threatening reactions to amphotericin B. Both cases were treated with a combination of posaconazole-caspofungin favorably with no evidence of recurrence upon long-term follow-up. To our knowledge, this is the first report of successful treatment of invasive mucormycosis with azole-echinocandin combination. It may suggest that caspofungin exerts additional or even synergistic antimucoral effects to posaconazole.
authors.affiliation: Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
authors.forename: Fereshte
authors.initials: F
authors.lastname: Sheybani
authors.affiliation: Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
authors.forename: HamidReza
authors.initials: HR
authors.lastname: Naderi
authors.affiliation: Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
authors.forename: MohammadReza
authors.initials: M
authors.lastname: Sarvghad
authors.affiliation: Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
authors.forename: MohammadJavad
authors.initials: M
authors.lastname: Ghabouli
authors.affiliation: Department of infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Imam Reza Teaching Hospital, Mashhad 9137913316, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Arian
keywords: Azole–echinocandin; Caspofungin; Mucormycosis; Posaconazole
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