title: Profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches.
abstract: High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches.
authors.affiliation: Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.|Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.|Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. lluis.nisa@dkf.unibe.ch.
authors.forename: Lluís
authors.initials: L
authors.lastname: Nisa
authors.affiliation: Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. daniel.aebersold@insel.ch.|Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. daniel.aebersold@insel.ch.
authors.forename: Daniel Matthias
authors.initials: DM
authors.lastname: Aebersold
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. roland.giger@insel.ch.
authors.forename: Roland
authors.initials: R
authors.lastname: Giger
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. marco.caversaccio@insel.ch.
authors.forename: Marco Domenico
authors.initials: MD
authors.lastname: Caversaccio
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. urs.borner@insel.ch.
authors.forename: Urs
authors.initials: U
authors.lastname: Borner
authors.affiliation: Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.|Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. michaela.medova@dkf.unibe.ch.
authors.forename: Michaela
authors.initials: M
authors.lastname: Medová
authors.affiliation: Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.|Department of Clinical Research, Inselspital, Bern University Hospital, and University of Bern, MEM-E807, Murtenstrasse 35, Bern 3010, Switzerland. yitzhak.zimmer@insel.ch.
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Zimmer
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