title: Human cerebral blood volume measurements using dynamic contrast enhancement in comparison to dynamic susceptibility contrast MRI.
abstract: BACKGROUND
  Cerebral blood volume (CBV) is an important parameter for the assessment of brain tumors, usually obtained using dynamic susceptibility contrast (DSC) MRI. However, this method often suffers from low spatial resolution and high sensitivity to susceptibility artifacts and usually does not take into account the effect of tissue permeability. The plasma volume (vp) can also be extracted from dynamic contrast enhancement (DCE) MRI. The aim of this study was to investigate whether DCE can be used for the measurement of cerebral blood volume in place of DSC for the assessment of patients with brain tumors.
  
  
  METHODS
  Twenty-eight subjects (17 healthy subjects and 11 patients with glioblastoma) were scanned using DCE and DSC. vp and CBV values were measured and compared in different brain components in healthy subjects and in the tumor area in patients.
  
  
  RESULTS
  Significant high correlations were detected between vp and CBV in healthy subjects in the different brain components; white matter, gray matter, and arteries, correlating with the known increased tissue vascularity, and within the tumor area in patients.
  
  
  CONCLUSIONS
  This work proposes the use of DCE as an alternative method to DSC for the assessment of blood volume, given the advantages of its higher spatial resolution, its lower sensitivity to susceptibility artifacts, and its ability to provide additional information regarding tissue permeability.
authors.affiliation: Functional Brain Center, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv, 64239, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Artzi
authors.forename: Gilad
authors.initials: G
authors.lastname: Liberman
authors.forename: Guy
authors.initials: G
authors.lastname: Nadav
authors.forename: Faina
authors.initials: F
authors.lastname: Vitinshtein
authors.forename: Deborah T
authors.initials: DT
authors.lastname: Blumenthal
authors.forename: Felix
authors.initials: F
authors.lastname: Bokstein
authors.forename: Orna
authors.initials: O
authors.lastname: Aizenstein
authors.forename: Dafna
authors.initials: D
authors.lastname: Ben Bashat
mesh_terms: D000328:Adult; D001810:Blood Volume; D001811:Blood Volume Determination / Q000379:methods*; D001932:Brain Neoplasms / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003287:Contrast Media; D005260:Female; D005909:Glioblastoma / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D003287:Contrast Media
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