title: Megaloblastic anemia presenting with massive reversible splenomegaly.
abstract: Megaloblastic anemia (MA) is a common disorder with varied manifestations. It generally results in mild to moderate splenomegaly which is due to sequestration of macrocytic erythrocytes in spleen. Massive splenomegaly is generally seen in infections, myeloproliferative diseases, neoplasms, storage disorders or hematological conditions; but is not heard of and has rarely been reported in MA. We discuss a case of massive splenomegaly who presented with symptomatic anemia and was found to have MA. He was extensive evaluated for all other causes of massive splenomegaly which was normal. Further, after a therapeutic trial of MA he showed a regression in spleen size confirming that the massive splenomegaly was attributable to MA.
authors.affiliation: Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 India.
authors.forename: Vineet
authors.initials: V
authors.lastname: Behera
authors.affiliation: Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 India.
authors.forename: Makarand
authors.initials: M
authors.lastname: Randive
authors.affiliation: Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 India.
authors.forename: Velu
authors.initials: V
authors.lastname: Nair
keywords: Massive splenomegaly; Megaloblastic anemia; Splenomegaly
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