title: Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery.
abstract: A set of novel SO2-containing azabicyclo[3.n.1]alkanes has been synthesized by the double-Mannich annulation of of the corresponding monocyclic S-ketones. These compounds have been rationally designed as 3D-shaped, conformationally restricted SO2-containing building blocks for drug discovery.
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.|‡Department of Chemistry, National Taras Shevchenko University of Kyiv, Volodymyrska 64, Kyiv 01033, Ukraine.
authors.forename: Tetiana
authors.initials: T
authors.lastname: Druzhenko
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.
authors.forename: Olexandr
authors.initials: O
authors.lastname: Denisenko
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kheylik
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.
authors.forename: Sergey
authors.initials: S
authors.lastname: Zozulya
authors.affiliation: §STC 'Institute for Single Crystals', NAS of Ukraine 60 Lenina Avenue, Kharkiv 61001, Ukraine.
authors.forename: Svitlana S
authors.initials: SS
authors.lastname: Shishkina
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.|‡Department of Chemistry, National Taras Shevchenko University of Kyiv, Volodymyrska 64, Kyiv 01033, Ukraine.
authors.forename: Andrei
authors.initials: A
authors.lastname: Tolmachev
authors.affiliation: †Enamine, Ltd., Chervonotkatska 78, Kyiv 01103, Ukraine.|‡Department of Chemistry, National Taras Shevchenko University of Kyiv, Volodymyrska 64, Kyiv 01033, Ukraine.
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk
mesh_terms: D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D055808:Drug Discovery; D015394:Molecular Structure; D013458:Sulfur Dioxide / Q000737:chemistry*
chemical_list: D053961:Azabicyclo Compounds; D013458:Sulfur Dioxide