title: Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases.
abstract: Vaccination, which provides effective, safe infectious disease protection, is among the most important recent public health and immunological achievements. However, infectious disease remains the leading cause of death in developing countries because several vaccines require repeated administrations and children are often incompletely immunized. Microsphere-based systems, providing controlled release delivery, can obviate the need for repeat immunizations. Here, we review the function of sustained and pulsatile release of biodegradable polymeric microspheres in parenteral and mucosal single-dose vaccine administration. We also review the active-targeting function of polymeric particles. With their shield and co-delivery functions, polymeric particles are applied to develop single-dose and mucosally administered vaccines as well as to improve subunit vaccines. Because polymeric particles are easily surface-modified, they have been recently used in vaccine development for cancers and many infectious diseases without effective vaccines (e.g., human immunodeficiency virus infection). These polymeric particle functions yield important vaccine carriers and multiple benefits.
authors.affiliation: a Food and Drug Administration ; Ministry of Health and Welfare ; Taiwan (R.O.C.).
authors.forename: Chi-Ying
authors.initials: CY
authors.lastname: Lin
authors.forename: Shih-Jie
authors.initials: SJ
authors.lastname: Lin
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Yang
authors.forename: Der-Yuan
authors.initials: DY
authors.lastname: Wang
authors.forename: Hwei-Fang
authors.initials: HF
authors.lastname: Cheng
authors.forename: Ming-Kung
authors.initials: MK
authors.lastname: Yeh
mesh_terms: D063566:Biodegradable Plastics; D003141:Communicable Diseases / Q000453:epidemiology*; D004337:Drug Carriers / Q000008:administration & dosage*; D006801:Humans; D008863:Microspheres; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D063566:Biodegradable Plastics; D004337:Drug Carriers; D014612:Vaccines
keywords: APC,antigen-presenting cell; DC, dendritic cell; DEN-1–DEN-4, dengue virus serotypes 1–4; DT or TD, diphtheria + tetanus vaccine; DT, diphtheria toxoid; DTP, diphtheria + tetanus + pertussis vaccine; NS1, nonstructural protein 1; PEG, poly (ethylene glycol); PLA, poly (lactide); PLGA, Poly (lactic-co-glycolic acid); TT, tetanus-toxoid; VC, Vibrio cholera; WHO, World Health Organization; biodegradable; immunization; infectious diseases; polymeric microspheres; vaccines
references.citation: J Immunol. 2004 Sep 1;173(5):3148-54
references.pmid: 15322175
references.citation: J Drug Target. 1996;3(6):455-67
references.pmid: 8863138
references.citation: Biomaterials. 2005 Oct;26(28):5727-36
references.pmid: 15878378
references.citation: Infect Immun. 1999 Jun;67(6):2884-90
references.pmid: 10338495
references.citation: Adv Drug Deliv Rev. 2005 Jan 10;57(3):391-410
references.pmid: 15560948
references.citation: J Pharm Sci. 1996 Jun;85(6):547-52
references.pmid: 8773947
references.citation: Adv Drug Deliv Rev. 1998 Jul 6;32(3):225-246
references.pmid: 10837646
references.citation: Curr Opin Mol Ther. 2009 Feb;11(1):72-80
references.pmid: 19169962
references.citation: Nat Med. 1999 Nov;5(11):1249-55
references.pmid: 10545990
references.citation: Nat Immunol. 2011 Jun;12(6):509-17
references.pmid: 21739679
references.citation: Pharm Biotechnol. 1995;6:389-412
references.pmid: 7551227
references.citation: Pan Afr Med J. 2013;14:3
references.pmid: 23504493
references.citation: Infect Immun. 1997 May;65(5):1716-21
references.pmid: 9125552
references.citation: Clin Infect Dis. 2008 Aug 1;47(3):401-9
references.pmid: 18558875
references.citation: Nat Med. 2004 Aug;10(8):806-10
references.pmid: 15286782
references.citation: Nat Med. 2004 May;10(5):475-80
references.pmid: 15122249
references.citation: Vaccine. 1999 Sep;18(3-4):209-15
references.pmid: 10506644
references.citation: J Control Release. 2002 Aug 21;82(2-3):237-47
references.pmid: 12175740
references.citation: Biomaterials. 2011 Oct;32(28):6791-803
references.pmid: 21724247
references.citation: J Food Drug Anal. 2014 Mar;22(1):95-104
references.pmid: 24673907
references.citation: Int J Nanomedicine. 2014;9:813-22
references.pmid: 24550673
references.citation: Trends Biotechnol. 1999 Jan;17(1):25-9
references.pmid: 10098275
references.citation: Biomaterials. 2007 Nov;28(33):4991-9
references.pmid: 17707503
references.citation: Infect Immun. 2001 Dec;69(12):7481-6
references.pmid: 11705923
references.citation: J Immunol. 2002 Jul 1;169(1):566-74
references.pmid: 12077289
references.citation: Adv Drug Deliv Rev. 1997 Oct 13;28(1):97-119
references.pmid: 10837567
references.citation: Front Cell Infect Microbiol. 2013;3:13
references.pmid: 23532930
references.citation: Vaccine. 2000 Dec 8;19(9-10):1047-54
references.pmid: 11137238
references.citation: J Food Drug Anal. 2014 Mar;22(1):76-85
references.pmid: 24673905
references.citation: J Food Drug Anal. 2014 Mar;22(1):64-75
references.pmid: 24673904
references.citation: Vaccine. 1994 Mar;12(4):299-306
references.pmid: 8178550
references.citation: Vaccine. 1996 Oct;14(15):1429-38
references.pmid: 8994318
references.citation: J Food Drug Anal. 2014 Mar;22(1):86-94
references.pmid: 24673906
references.citation: Pharm Res. 1995 Nov;12(11):1796-800
references.pmid: 8592689
references.citation: Int J Nanomedicine. 2013;8:1683-96
references.pmid: 23761969
references.citation: Pharm Res. 1993 Jul;10(7):945-53
references.pmid: 8378256
references.citation: Nat Rev Cancer. 2012 Apr;12(4):265-77
references.pmid: 22437871
references.citation: Biomaterials. 2011 May;32(14):3666-78
references.pmid: 21345488
references.citation: J Control Release. 2001 Jan 29;70(1-2):1-20
references.pmid: 11166403
references.citation: J Food Drug Anal. 2014 Mar;22(1):105-15
references.pmid: 24673908
references.citation: J Food Drug Anal. 2014 Mar;22(1):1-2
references.pmid: 24673899
references.citation: Vaccine. 1993;11(5):596-7
references.pmid: 8488720
references.citation: Vaccine. 1995 Aug;13(11):1006-12
references.pmid: 8525683
references.citation: Methods Enzymol. 1985;112:101-16
references.pmid: 4046844
references.citation: J Clin Invest. 2013 Feb;123(2):844-54
references.pmid: 23298832
references.citation: J Pharm Sci. 1996 Dec;85(12):1261-70
references.pmid: 8961136
references.citation: J Food Drug Anal. 2014 Mar;22(1):147-60
references.pmid: 24673911
references.citation: Blood. 2013 Apr 11;121(15):2836-44
references.pmid: 23390195
references.citation: Nat Rev Immunol. 2014 Oct;14(10):705-11
references.pmid: 25190285
references.citation: Eur J Immunol. 2008 May;38(5):1404-13
references.pmid: 18389478
references.citation: Immunobiology. 1992 Feb;184(2-3):113-25
references.pmid: 1587538
references.citation: J Interferon Cytokine Res. 1999 May;19(5):455-62
references.pmid: 10386857
references.citation: Adv Exp Med Biol. 1989;251:191-202
references.pmid: 2610110
references.citation: J Food Drug Anal. 2014 Mar;22(1):116-27
references.pmid: 24673909
references.citation: Annu Rev Biomed Eng. 2012;14:17-46
references.pmid: 22524387
references.citation: J Pharm Sci. 2003 May;92(5):957-66
references.pmid: 12712415
references.citation: Am J Physiol. 1998 Jul;275(1 Pt 1):G130-7
references.pmid: 9655693
references.citation: J Control Release. 2010 Jun 1;144(2):118-26
references.pmid: 20156497
references.citation: Nature. 1989 Nov 9;342(6246):115-20
references.pmid: 2812009
references.citation: J Immunol. 2008 Mar 15;180(6):3647-50
references.pmid: 18322168
references.citation: Vaccine. 2010 Aug 31;28(38):6282-91
references.pmid: 20638455
references.citation: Vaccine. 1995 May;13(7):683-9
references.pmid: 7668038
references.citation: Biotechnol Bioeng. 2012 Jun;109(6):1443-60
references.pmid: 22407777
references.citation: Biotechnol Bioeng. 2007 Feb 1;96(2):203-9
references.pmid: 17191251
references.citation: J Microencapsul. 2004 Feb;21(1):91-106
references.pmid: 14718189
references.citation: J Pharm Sci. 2009 Apr;98(4):1278-316
references.pmid: 18704954
references.citation: Vaccine. 1998 Apr;16(7):698-707
references.pmid: 9562689
references.citation: J Virol. 2001 Jun;75(11):5416-20
references.pmid: 11333927
references.citation: Methods Enzymol. 2012;509:143-63
references.pmid: 22568905
references.citation: Infect Immun. 1997 Jul;65(7):2676-84
references.pmid: 9199436
references.citation: Int J Nanomedicine. 2013;8:3161-9
references.pmid: 23990724
references.citation: Immunity. 2008 Sep 19;29(3):319-24
references.pmid: 18799140
references.citation: Vaccine. 2008 Mar 20;26(13):1626-37
references.pmid: 18295941
references.citation: Lancet. 2008 Jul 12;372(9633):164-75
references.pmid: 18620952
references.citation: Int J Pharm. 2002 Mar 2;234(1-2):75-90
references.pmid: 11839439
references.citation: J Control Release. 2013 Jan 10;165(1):62-74
references.pmid: 23103983