title: Comparative pharmacokinetics of oxytetracycline in blunt-snout bream (Megalobrama amblycephala) with single and multiple-dose oral administration.
abstract: Research into the pharmacokinetics and residue elimination of oxytetracycline (OTC) is important both to determine the optimal dosage regimens and to establish a safe withdrawal time in fish. A depletion study is presented here for OTC in Megalobrama amblycephala with a single-dose (100 mg/kg) and multiple-dose (100 mg/kg for five consecutive days) oral administration. The study was conducted at 25 °C. As a result, a one-compartment model was developed. For the single dose, the absorption half-life was 5.79, 9.40, 6.96, and 8.06 h in the plasma, liver, kidney, and muscle, respectively. However, the absorption half-life was 3.62, 7.33, 4.59, and 6.02 h with multiple-dose oral administration. The elimination half-time in the plasma, liver, kidney, and muscle was 58.63, 126.43, 65.1, and 58.85 h when M. amblycephala was treated with a single dose. However, the elimination half-time changed to 91.75, 214.87, 126.22, and 135.84 h with multiple-dose oral administration.
authors.affiliation: Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, Wuhan, 430070, Hubei Province, China.
authors.forename: Ru-Qin
authors.initials: RQ
authors.lastname: Li
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Ren
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Can
authors.initials: C
authors.lastname: Huang
authors.forename: Jun-Hui
authors.initials: JH
authors.lastname: Shao
authors.forename: Xiao-Xuan
authors.initials: XX
authors.lastname: Chen
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Wu
mesh_terms: D065966:Absorption, Physicochemical; D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D003530:Cyprinidae / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D010118:Oxytetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D010118:Oxytetracycline
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