title: Prevalence and evolution of scleroderma pattern at nailfold videocapillaroscopy in systemic sclerosis patients: Clinical and prognostic implications.
abstract: BACKGROUND
  Microvascular involvement plays a decisive role in systemic sclerosis (SSc) pathogenesis occurring early in the course of the disease. Microangiopathy is responsible of important clinical manifestations, such as Raynaud's phenomenon, digital ulceration, and pulmonary arterial hypertension. Typical microvascular alterations, called scleroderma pattern, are detectable at nailfold capillaroscopy in a significant percentage of SSc patients; however its prevalence is highly variable in published studies.
  
  
  OBJECTIVE
  The aims of this study are to evaluate the prevalence and the evolution of scleroderma pattern in SSc patients and analyze their demographic, clinical and prognostic characteristics according to capillaroscopic features.
  
  
  METHODS
  Two hundred and seventy-five SSc patients, underwent at least two nailfold videocapillaroscopy during follow-up, were retrospectively enrolled.
  
  
  RESULTS
  A scleroderma pattern was observed in 80% of patients at baseline and 87.1% during follow-up, and it was significantly associated to digital ulcers, interstitial lung disease, reduction of diffusion lung of carbon monoxide <75%, teleangectasias and melanodermia, while sicca syndrome and arthralgias were associated to normal/nonspecific pattern. Digital ulcers, teleangectasias, sicca syndrome, and arthralgias remained independently associated with scleroderma pattern on multivariate analysis. In conclusion, the main clinical manifestation correlated with scleroderma pattern is the occurrence of digital ulcers, and their appearance is strictly correlated with the variation of capillaroscopic feature during the time. Further studies should confirm the association between SSc pattern and lung fibrosis.
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ghizzoni
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy. Electronic address: marco.sebastiani@unimore.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Sebastiani
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Andreina
authors.initials: A
authors.lastname: Manfredi
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Campomori
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Colaci
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Dilia
authors.initials: D
authors.lastname: Giuggioli
authors.affiliation: Rheumatology Unit, University of Modena and Reggio Emilia, Italy.
authors.forename: Clodoveo
authors.initials: C
authors.lastname: Ferri
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000737:chemistry; D002196:Capillaries / Q000473:pathology; D002248:Carbon Monoxide / Q000737:chemistry; D004058:Diffusion; D005260:Female; D005385:Fingers / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008171:Lung Diseases / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D020678:Microscopic Angioscopy / Q000379:methods*; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D015995:Prevalence; D011379:Prognosis; D011928:Raynaud Disease / Q000150:complications; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D012883:Skin Ulcer / Q000473:pathology; D014456:Ulcer / Q000503:physiopathology
chemical_list: D001323:Autoantibodies; D002248:Carbon Monoxide
keywords: Digital ulcers; Interstitial lung disease; Nailfold videocapillaroscopy; Scleroderma; Systemic sclerosis