title: Site-specific in situ synthesis of eumelanin nanoparticles by an enzymatic autodeposition-like process.
abstract: A method for in situ formation and controlled deposition of eumelanin nanoparticles is presented. The particles are built up by enzymatic reaction of l-DOPA with tyrosinase. The enzyme is tethered onto the support surface to get site-specific deposition of eumelanin. Due to the immediate deposition, the particles are monodisperse, with diameters of about 30-60 nm. Up to now, eumelanin particles have only been observed with sizes of about 200 nm. Deposition of those particles is site-specific on the areas where enzyme is present and results in different kinds of patterns on the support surface, including versatile monolayer structures.
authors.affiliation: †University of Paderborn, Department of Chemistry - Biobased and Bioinspired Materials, Warburger Str. 100, D-33098 Paderborn, Germany.
authors.forename: Oliver I
authors.initials: OI
authors.lastname: Strube
authors.affiliation: †University of Paderborn, Department of Chemistry - Biobased and Bioinspired Materials, Warburger Str. 100, D-33098 Paderborn, Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Büngeler
authors.affiliation: ‡University of Paderborn, Department of Chemistry - Coating Materials and Polymers, Warburger Str. 100, D-33098 Paderborn, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bremser
mesh_terms: D007980:Levodopa / Q000737:chemistry; D008543:Melanins / Q000138:chemical synthesis / Q000737:chemistry*; D014442:Monophenol Monooxygenase / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D008543:Melanins; C041877:eumelanin; D007980:Levodopa; D014442:Monophenol Monooxygenase