title: Does ketamine target olfactory receptors in the brain?
abstract: The findings of Ho et al. in this issue of Science Signaling suggest that the anesthetic ketamine binds to and activates select olfactory receptors in mouse brain, raising the possibility that ketamine targets a similar set of GPCRs in humans.
authors.affiliation: Department of Biophysics, Ruhr-University Bochum, 44780 Bochum, Germany. Department of Biophysics, CAS-MPG Partner Institute for Computational Biology, Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China.
authors.forename: Steffen
authors.initials: S
authors.lastname: Wolf
authors.affiliation: Department of Cell Physiology, Ruhr-University Bochum, 44780 Bochum, Germany.
authors.forename: Hanns
authors.initials: H
authors.lastname: Hatt
authors.affiliation: Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. oliver.ernst@utoronto.ca.
authors.forename: Oliver P
authors.initials: OP
authors.lastname: Ernst
mesh_terms: D000778:Anesthetics, Dissociative / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D007649:Ketamine / Q000378:metabolism*; D051379:Mice; D018035:Receptors, Odorant / Q000378:metabolism*
chemical_list: D000778:Anesthetics, Dissociative; D018035:Receptors, Odorant; D007649:Ketamine