title: Nanostructured medical sutures with antibacterial properties.
abstract: Bacterial repellence in suture materials is a desirable property that can potentially improve the healing process by preventing infection. We describe a method for generating nanostructures at the surface of commercial sutures of different composition, and their potential for preventing biofilm formation. We show how bacteria attachment is altered in the presence of nanosized topographies and identify optimum designs for preventing it without compromising biocompatibility and applicability in terms of nanostructure robustness or tissue friction. These studies open new possibilities for flexible and cost-effective realization of topography-based antibacterial coatings for absorbable biomedical textiles.
authors.affiliation: Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Cristina
authors.initials: C
authors.lastname: Serrano
authors.affiliation: Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Luis
authors.initials: L
authors.lastname: García-Fernández
authors.affiliation: Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Fernández-Blázquez
authors.affiliation: Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Mike
authors.initials: M
authors.lastname: Barbeck
authors.affiliation: Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Shahram
authors.initials: S
authors.lastname: Ghanaati
authors.affiliation: Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
authors.forename: Ron
authors.initials: R
authors.lastname: Unger
authors.affiliation: Institute of Pathology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
authors.forename: James
authors.initials: J
authors.lastname: Kirkpatrick
authors.affiliation: INM - Leibniz Institute for New Materials and Saarland University, Saarbrücken, Germany.
authors.forename: Eduard
authors.initials: E
authors.lastname: Arzt
authors.affiliation: B. Braun Surgical, S.A, Rubi, Barcelona, Spain.
authors.forename: Lutz
authors.initials: L
authors.lastname: Funk
authors.affiliation: B. Braun Surgical, S.A, Rubi, Barcelona, Spain.
authors.forename: Pau
authors.initials: P
authors.lastname: Turón
authors.affiliation: Max-Planck-Institut für Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany. Electronic address: delcampo@mpip-mainz.mpg.de.
authors.forename: Aránzazu
authors.initials: A
authors.lastname: del Campo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001422:Bacterial Adhesion; D001672:Biocompatible Materials / Q000737:chemistry*; D018441:Biofilms; D002645:Chickens; D003362:Cost-Benefit Analysis; D016503:Drug Delivery Systems; D004926:Escherichia coli / Q000502:physiology; D005260:Female; D051379:Mice; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties; D013537:Sutures
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011108:Polymers; D010100:Oxygen
keywords: Antibacterial; Antifouling; Nanopatterning; Plasma treatment; Sutures