title: Autologous serum and plasma rich in growth factors in ophthalmology: preclinical and clinical studies.
abstract: The use of blood derivatives represents an alternative therapeutic approach that is gaining interest in regenerative medicine due to its potential to stimulate and accelerate tissue healing. Autologous serum eye drops and platelet-enriched plasma eye drops are being used in the treatment of different ophthalmological disorders. In this review, we summarize the different blood-derived formulations used in the treatment and care of ocular surface disorders. The biological basis and use of autologous serum and plasma rich in growth factors are deeply evaluated as well as the challenges to be addressed in the future in this new generation of blood-derived therapies.
authors.affiliation: BTI Biotechnology Institute, Vitoria, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.affiliation: BTI Biotechnology Institute, Vitoria, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Muruzabal
authors.affiliation: Microbiology & Immunology, Walter G. Ross Chair in Ophthalmic Research, Ocular Surface Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Tayebba
authors.affiliation: Fernandez-Vega Ophthalmological Institute, Eye Research Foundation, University of Oviedo, Oviedo, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Riestra
authors.affiliation: Microbiology & Immunology, Walter G. Ross Chair in Ophthalmic Research, Ocular Surface Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Victor L
authors.initials: VL
authors.lastname: Perez
authors.affiliation: Fernandez-Vega Ophthalmological Institute, Eye Research Foundation, University of Oviedo, Oviedo, Spain.
authors.forename: Jesus
authors.initials: J
authors.lastname: Merayo-Lloves
authors.affiliation: BTI Biotechnology Institute, Vitoria, Spain.
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
mesh_terms: D001769:Blood; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D005128:Eye Diseases / Q000628:therapy*; D006801:Humans; D009885:Ophthalmology; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D053657:Platelet-Rich Plasma / Q000502:physiology*
chemical_list: D010982:Platelet-Derived Growth Factor
keywords: autologous serum; cornea; dry eye; eye; ocular surface; plasma rich in growth factors; platelet-rich plasma