title: Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology?
abstract: Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.
authors.affiliation: Department of Anatomical Pathology and Cytology, Global Hospitals, Hyderabad, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Radha
authors.affiliation: Department of Anatomical Pathology and Cytology, Global Hospitals, Hyderabad, Andhra Pradesh, India.
authors.forename: T
authors.initials: T
authors.lastname: Afroz
authors.affiliation: Department of Nephrology, Gandhi Medical College, Secunderabad, Andhra Pradesh, India.
authors.forename: Ch R
authors.initials: ChR
authors.lastname: Prasad
authors.affiliation: Department of Nephrology, Global Hospitals, Hyderabad, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Sridhar
authors.affiliation: Department of Nephrology, Hyderabad Kidney and Laparoscopic Centre, Hyderabad, Andhra Pradesh, India.
authors.forename: K G
authors.initials: KG
authors.lastname: Rajaram
authors.affiliation: Department of Nephrology, Global Hospitals, Hyderabad, Andhra Pradesh, India.
authors.forename: S
authors.initials: S
authors.lastname: Reddy
keywords: Focal segmental glomerulosclerosis; kidney transplantation; renal allografts
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