title: Third eyelid gland neoplasms of dogs and cats: a retrospective histopathologic study of 145 cases.
abstract: OBJECTIVE
  To describe the various types of primary neoplasms affecting the third eyelid (TEL) gland of dogs and cats.
  
  
  METHODS
  A retrospective search of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) database was performed. Veterinary ophthalmologists, primary care veterinarians, and, when appropriate, owners were contacted for patient follow-up information. Patient data points collected included species, age, sex, breed, laterality, tumor type, surgical margins, recurrence, metastasis, and length of follow-up.
  
  
  RESULTS
  A total of 127 canine and 18 feline cases met the inclusion criteria. The most common canine TEL gland tumor was adenocarcinoma (n = 108; 85.0%) followed by adenoma (n = 18; 14.2%) and squamous cell carcinoma (SCC) (n = 1; 0.8%). For canine cases with follow-up information available (n = 62), 8.1% had confirmed or suspected metastasis and 11.3% had confirmed or suspected local recurrence of disease. The most common feline TEL gland tumor was adenocarcinoma (n = 15; 83.3%) followed by SCC (n = 3; 16.7%). For feline cases with follow-up information available (n = 9), 40.0% had confirmed or suspected metastasis and 30.0% had confirmed or suspected local recurrence of disease.
  
  
  CONCLUSIONS
  This study determined that adenocarcinoma was the most common third eyelid gland tumor in both dogs and cats. The overall survival times were less, and metastatic occurrence and recurrence rates appeared to be higher for feline tumors as compared to those diagnosed in dogs. This is the first report of SCC originating from glandular ductular epithelium.
authors.affiliation: From Eye Care for Animals, 12419 Metric Blvd, Austin, TX, 78758, USA.
authors.forename: D Dustin
authors.initials: DD
authors.lastname: Dees
authors.affiliation: Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Schobert
authors.affiliation: Comparative Ocular Pathology Laboratory of Wisconsin, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Dubielzig
authors.affiliation: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI, 53706, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Stein
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D002371:Cat Diseases / Q000401:mortality / Q000473:pathology*; D002415:Cats; D004283:Dog Diseases / Q000401:mortality / Q000473:pathology*; D004285:Dogs; D005142:Eyelid Neoplasms / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D009541:Nictitating Membrane / Q000473:pathology*; D012189:Retrospective Studies; D015996:Survival Rate
keywords: adenocarcinoma; adenoma; canine; feline; squamous cell carcinoma; third eyelid gland