title: Effects of Valerianae Radix et Rhizoma extract on psychological stress in mice.
abstract: BACKGROUND
  The aim of this study was to identify the effects of Valerianae Radix et Rhizoma water extract (VRe) originated from Valeriana fauriei Briquet on reducing psychological stress (PS) on mice.
  
  
  OBJECTIVE
  Mice were put under PS with communication box method: Restraining mice and forcing to see other mice underfoot shock stress.
  
  
  METHODS
  Measurements on plasma corticosterone, noradrenaline and lipid peroxidation, and elevated plus-maze (EPM) tests were carried out to determine the effect of VRe administration on physiological and behavioral responses of mice.
  
  
  RESULTS
  VRe showed anxiolytic effects in plasma corticosterone, noradrenaline, and EPM transfer latency levels, but it did not show any significant effects on the other indicators.
  
  
  CONCLUSIONS
  V. fauriei, which has been used as a natural anxiolytic drug, exerts positive effects in the communication box induced PS in mice.
authors.affiliation: Department of Health Service and Population Research, Institute of Psychiatry, King's College of London, London, UK.
authors.forename: Jeong Suk
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Sport Science, College of Sport Science, Pusan National University, Yangsan, Gyeongnam, Republic of Korea.
authors.forename: Jeong Deok
authors.initials: JD
authors.lastname: Ahn
authors.affiliation: Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam, Republic of Korea.
authors.forename: Su-In
authors.initials: SI
authors.lastname: Cho
keywords: Communication box; Valeriana fauriei briquet; psychological stress; valerianae radix et rhizoma
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