title: Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy.
abstract: Small-conductance Ca(2+)-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels because they might constitute a relatively atrial-selective target. This review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how antiarrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and it is hoped that this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.
authors.affiliation: *Acesion Pharma, Copenhagen, Denmark; Departments of †Biomedical Science; and ‡Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jonas G
authors.initials: JG
authors.lastname: Diness
authors.forename: Bo H
authors.initials: BH
authors.lastname: Bentzen
authors.forename: Ulrik S
authors.initials: US
authors.lastname: Sørensen
authors.forename: Morten
authors.initials: M
authors.lastname: Grunnet
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D015507:Drugs, Investigational / Q000627:therapeutic use; D006329:Heart Conduction System / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D058990:Molecular Targeted Therapy; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D024681:Potassium Channels, Calcium-Activated / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000889:Anti-Arrhythmia Agents; D015507:Drugs, Investigational; D026902:Potassium Channel Blockers; D024681:Potassium Channels, Calcium-Activated
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