title: Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12.
abstract: microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, No. 200, Huihe Road, Wuxi, 214062, China.
authors.forename: Zongtao
authors.initials: Z
authors.lastname: Xie
authors.forename: Liming
authors.initials: L
authors.lastname: Cai
authors.forename: Runsheng
authors.initials: R
authors.lastname: Li
authors.forename: Jinyu
authors.initials: J
authors.lastname: Zheng
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wu
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Yang
authors.forename: Hu
authors.initials: H
authors.lastname: Li
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009363:Neoplasm Proteins; D063151:Polycomb Repressive Complex 2 / Q000096:biosynthesis* / Q000235:genetics; D014157:Transcription Factors
chemical_list: D014408:Biomarkers, Tumor; C552418:MIRN489 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; C430461:SUZ12 protein, human; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2
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