title: Association between cadherin-17 expression and pathological characteristics of gastric cancer: a meta-analysis.
abstract: OBJECTIVE
  To construct a meta-analysis in order to examine the relationship between cadherin-17 (CDH17) and gastric cancer (GC).
  
  
  METHODS
  Related articles were selected by searching the following English or Chinese electronic databases: CINAHL, MEDLINE, Science Citation Index, the Chinese Journal Full-Text, and the Weipu Journal. Newcastle-Ottawa Scale (NOS) criteria were used to ensure consistency in reviewing and reporting results. Statistical analyses were conducted with Version 12.0 STATA statistical software.
  
  
  RESULTS
  Ultimately, 11 articles, with a total of 2,120 GC patients, were found to be eligible for study inclusion. In comparisons of GC patients by TNM stage (III-IV vs I-II: OR = 2.35, 95%CI: 1.15-4.825, P = 0.019), histologic grade (3-4 vs 1-2: OR = 3.48, 95%CI: 1.36-8.92, P = 0.009), invasion grade (T3-4 vs T1-2: OR = 2.86; 95%CI: 1.69-4.83; P = 0.000), and lymph node metastasis (positive vs negative: OR = 2.64; 95%CI: 1.33-5.27; P = 0.006), it was found that CDH17 showed more positive expressions in each of the more severe cases. Country-stratified analyses from all four experimental subgroups showed that high CDH17 expression levels may be related to GC among Chinese and Korean populations (all P < 0.05), with the exception of the invasion grade T3-4 vs T1-2 comparison, where the relation only held among the Chinese population (OR = 2.86, 95%CI: 1.69-4.83, P = 0.000).
  
  
  CONCLUSIONS
  Collectively, the data reflects the capacity of CDH17 in tumor proliferation and metastasis among GC patients.
authors.affiliation: Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Zi-Wen
authors.initials: ZW
authors.lastname: Long
authors.affiliation: Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Meng-Long
authors.initials: ML
authors.lastname: Zhou
authors.affiliation: Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Fu
authors.affiliation: Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Xian-Qun
authors.initials: XQ
authors.lastname: Chu
authors.affiliation: Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Ya-Nong
authors.initials: YN
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D016014:Linear Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016017:Odds Ratio; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C490584:CDH17 protein, human; D015820:Cadherins
keywords: Cadherin 17; Gastric cancer; Meta-analysis; Protein expression
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