title: Palladium catalyzed vinyltrifluoromethylation of aryl halides through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid.
abstract: An efficient Pd-catalyzed stereoselective vinyltrifluoromethylation of aryl halides, through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid is described. The ready availability of the starting materials, the high level of functional group tolerance, and excellent E/Z selectivity make this protocol a safe and operationally convenient strategy for efficient synthesis of vinyltrifluoromethyl derivatives.
authors.forename: Subban
authors.initials: S
authors.lastname: Kathiravan
authors.affiliation: ‡Department of Chemistry, BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
authors.forename: Ian A
authors.initials: IA
authors.lastname: Nicholls
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: C411824:2-(trifluoromethyl)acrylic acid; D000179:Acrylates; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D010165:Palladium