title: The impact of boundary conditions on surface curvature of polypropylene mesh in response to uniaxial loading.
abstract: Exposure following pelvic organ prolapse repair has been observationally associated with wrinkling of the implanted mesh. The purpose of this study was to quantify the impact of variable boundary conditions on the out-of-plane deformations of mesh subjected to tensile loading. Using photogrammetry and surface curvature analyses, deformed geometries were accessed for two commercially available products. Relative to standard clamping methods, the amount of out-of-plane deformation significantly increased when point loads were introduced to simulate suture fixation in-vivo. These data support the hypothesis that regional increases in the concentration of mesh potentially enhance the host׳s foreign body response, leading to exposure.
authors.affiliation: Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: wbb8@pitt.edu.
authors.forename: William R
authors.initials: WR
authors.lastname: Barone
authors.affiliation: Department of Bioengineering, University of Pittsburgh, Department of Biomedical Engineering, The University of Akron, 260 S. Forge St., Akron, OH 44325, USA. Electronic address: ramini@uakron.edu.
authors.forename: Rouzbeh
authors.initials: R
authors.lastname: Amini
authors.affiliation: Department of Bioengineering, University of Pittsburgh, 360B Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: spm54@pitt.edu.
authors.forename: Spandan
authors.initials: S
authors.lastname: Maiti
authors.affiliation: Magee-Womens Research Institute, Magee-Womens Hospital, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA. Electronic address: moalpa@mail.magee.edu.
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Moalli
authors.affiliation: Magee-Womens Research Institute, Magee-Womens Hospital, University of Pittsburgh, Musculoskeletal Research Center, Department of Bioengineering, University of Pittsburgh, 405 Center for Bioengineering, 300 Technology Drive, Pittsburgh, PA 15219, USA. Electronic address: sdast9@pitt.edu.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Abramowitch
mesh_terms: D003198:Computer Simulation; D019544:Equipment Failure Analysis; D005260:Female; D006801:Humans; D008422:Materials Testing; D056887:Pelvic Organ Prolapse / Q000601:surgery; D011126:Polypropylenes / Q000737:chemistry*; D019736:Prostheses and Implants; D013526:Surgical Mesh; D013537:Sutures; D013718:Tensile Strength
chemical_list: D011126:Polypropylenes
keywords: Boundary conditions; Exposure; Mesh; Pelvic organ prolapse; Photogrammetry; Surface curvature
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