title: Central and peripheral irisin differentially regulate blood pressure.
abstract: BACKGROUND
  Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown.
  
  
  OBJECTIVE
  To explore the effects of central and peripheral irisin on cardiovascular functions.
  
  
  METHODS
  Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured.
  
  
  RESULTS
  Administration of recombinant human irisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibility. Exogenous irisin reversed atenolol-induced inhibition of cardiac contractibility. In contrast, peripheral administration of irisin reduced blood pressure in both control and spontaneously hypertensive rats. Irisin dilated mesenteric artery rings through ATP-sensitive potassium channels.
  
  
  CONCLUSIONS
  Our studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities.
authors.affiliation: Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, Ann Arbor, MI, 48109, USA, weizhenz@umich.edu.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Chang
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Ruthann
authors.initials: R
authors.lastname: Zhang
authors.forename: Ziru
authors.initials: Z
authors.lastname: Li
authors.forename: Biaoxin
authors.initials: B
authors.lastname: Chai
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.forename: Eugene
authors.initials: E
authors.lastname: Chen
authors.forename: Michael
authors.initials: M
authors.lastname: Mulholland
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D005353:Fibronectins / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006801:Humans; D057967:Infusions, Intraventricular; D054086:KATP Channels / Q000187:drug effects / Q000502:physiology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: C577593:FNDC5 protein, human; C583676:FNDC5 protein, rat; D005353:Fibronectins; D054086:KATP Channels; D011994:Recombinant Proteins
references.citation: Nature. 2012 Jan 26;481(7382):463-8
references.pmid: 22237023
references.citation: Physiol Behav. 1977 Jul;19(1):171-3
references.pmid: 11803683
references.citation: Nature. 2012 Aug 30;488(7413):E9-10; discussion E10-1
references.pmid: 22932392
references.citation: Diabetes. 2014 Feb;63(2):514-25
references.pmid: 24150604
references.citation: Acta Physiol Scand. 2003 Mar;177(3):345-9
references.pmid: 12609005
references.citation: J Physiol. 2014 Mar 1;592(5):1091-107
references.pmid: 24297848
references.citation: FEBS J. 2014 Feb;281(3):739-49
references.pmid: 24237962
references.citation: Int J Biol Sci. 2014;10(3):338-49
references.pmid: 24644429
references.citation: Pharmacol Toxicol. 1992 Jul;71(1):3-10
references.pmid: 1523192
references.citation: Acta Diabetol. 2014 Oct;51(5):705-13
references.pmid: 24619655
references.citation: Peptides. 2014 Nov;61:130-6
references.pmid: 25261800
references.citation: Neuroscience. 2013 Jun 14;240:155-62
references.pmid: 23470775
references.citation: Nutr Diabetes. 2014 Feb 24;4:e110
references.pmid: 24567125
references.citation: Circ Res. 2010 Aug 20;107(4):540-8
references.pmid: 20558825
references.citation: Cell Metab. 2014 Feb 4;19(2):302-9
references.pmid: 24506871
references.citation: Adipocyte. 2013 Oct 1;2(4):289-93
references.pmid: 24052909
references.citation: Metabolism. 2013 Aug;62(8):1131-6
references.pmid: 23664146
references.citation: Neuroscience. 2013 Feb 12;231:296-304
references.pmid: 23219938
references.citation: Gene. 2002 Sep 4;297(1-2):79-83
references.pmid: 12384288
references.citation: Am J Physiol Endocrinol Metab. 2014 Mar 1;306(5):E512-8
references.pmid: 24398403
references.citation: Horm Metab Res. 2014 Feb;46(2):150-4
references.pmid: 24062088
references.citation: Endocrinology. 2010 Jan;151(1):134-42
references.pmid: 19934378
references.citation: Dev Dyn. 2002 Jun;224(2):154-67
references.pmid: 12112469
references.citation: Circulation. 2012 Aug 28;126(9):1067-78
references.pmid: 22855570
references.citation: Hypertension. 2001 Sep;38(3):384-8
references.pmid: 11566909
references.citation: Hypertension. 2007 Mar;49(3):647-52
references.pmid: 17190874
references.citation: BMC Med. 2013;11:235
references.pmid: 24191966