title: Disseminated histoplasmosis associated with acquired hemophagocytic lymphohistiocytosis.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening clinical syndrome caused by uncontrolled activation of lymphocytes and histiocytes resulting in high levels of cytokines. Acquired HLH occurs in autoimmune, inflammatory, infectious, and immunosuppressive disorders. Prompt identification and treatment of an underlying triggering cause improves clinical outcome.
authors.affiliation: Division of Hematopathology, The Ottawa Hospital Ottawa, Ontario, Canada ; Eastern Ontario Regional Laboratory Association Ottawa, Ontario, Canada.
authors.forename: Ashish
authors.initials: A
authors.lastname: Rajput
authors.affiliation: Division of Hematology, The Ottawa Hospital Ottawa, Ontario, Canada.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bence-Bruckler
authors.affiliation: Division of Hematology, The Ottawa Hospital Ottawa, Ontario, Canada.
authors.forename: Lothar
authors.initials: L
authors.lastname: Huebsch
authors.affiliation: Eastern Ontario Regional Laboratory Association Ottawa, Ontario, Canada ; Division of Microbiology, The Ottawa Hospital Ottawa, Ontario, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Jessamine
authors.affiliation: Eastern Ontario Regional Laboratory Association Ottawa, Ontario, Canada ; Division of Microbiology, The Ottawa Hospital Ottawa, Ontario, Canada.
authors.forename: Baldwin
authors.initials: B
authors.lastname: Toye
authors.affiliation: Division of Hematopathology, The Ottawa Hospital Ottawa, Ontario, Canada ; Eastern Ontario Regional Laboratory Association Ottawa, Ontario, Canada.
authors.forename: Ruth
authors.initials: R
authors.lastname: Padmore
keywords: Bone marrow; hemophagocytic lymphohistiocytosis; histoplasmosis