title: A formal anti-Markovnikov hydroamination of allylic alcohols via tandem oxidation/1,4-conjugate addition/1,2-reduction using a Ru catalyst.
abstract: A formal anti-Markovnikov hydroamination of allylic alcohols using a Ru catalyst via tandem oxidation/1,4-conjugate addition/1,2-reduction was developed. Thus, the reaction of allylic alcohols with amines was performed in the presence of the catalyst generated from RuClH(CO)(PPh3)3 and 2,6-bis(n-butyliminomethyl)pyridine in situ to afford the corresponding γ-amino alcohols efficiently.
authors.affiliation: Department of Biomedical Information, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, 610-0321, Japan. yoe@mail.doshisha.ac.jp.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohta
authors.forename: Yohei
authors.initials: Y
authors.lastname: Oe
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D010084:Oxidation-Reduction; D020005:Propanols / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000588:Amines; D056831:Coordination Complexes; D020005:Propanols; C006463:allyl alcohol; D012428:Ruthenium