title: [Current situation and perspectives of proton therapy].
abstract: Proton beam therapy is indicated as a treatment for some rare tumours and paediatric tumours because the technique allows a good local control with minimal toxicity; the growing number of centres that use proton beam therapy is associated with an increase of dosimetric and clinical data for other malignant tumours as well. This paper reviews potential indications of proton beam therapy. A systematic review on Medline was performed with the following keywords proton beam therapy, cancer, heavy particle, charged particle. No phase III trial has been published using proton beam therapy in comparison with the best photon therapy, but numerous retrospective and dosimetric studies have revealed an advantage of proton beam therapy compared to photons, above all in tumours next to parallel organs at risk (thoracic and abdominal tumours). This could be accompanied with a better safety profile and/or a better tumoural control; numerous phase 0, I, II, III and IV studies are ongoing to examine these hypotheses in more common cancers. Use of proton beam therapy is growing for common cancers within clinical trials but some indications could be applied sooner since in silico analysis showed major advantages with this technique.
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Doyen
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Bondiau
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: K
authors.initials: K
authors.lastname: Bénézéry
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: M-È
authors.initials: MÈ
authors.lastname: Chand
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Thariat
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: A
authors.initials: A
authors.lastname: Leysalle
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Gérard
authors.affiliation: Département de radiothérapie, centre François-Baclesse, 3, avenue du Général-Harris, 14076 Caen cedex 05, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Habrand
authors.affiliation: Pôle de radiothérapie, centre Antoine-Lacassagne, université Nice-Sophia, 33, avenue de Valombrose, 06000 Nice, France. Electronic address: jean-michel.hannoun-levi@nice.unicancer.fr.
authors.forename: J-M
authors.initials: JM
authors.lastname: Hannoun-Lévi
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D001984:Bronchial Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D002173:Cancer Care Facilities / Q000600:supply & distribution; D002277:Carcinoma / Q000453:epidemiology / Q000532:radiotherapy; D002986:Clinical Trials as Topic; D004067:Digestive System Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D005260:Female; D005602:France / Q000453:epidemiology; D006040:Goals; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D006285:Health Planning; D006297:Health Services Accessibility; D006689:Hodgkin Disease / Q000453:epidemiology / Q000532:radiotherapy; D006801:Humans; D008654:Mesothelioma / Q000453:epidemiology / Q000532:radiotherapy; D009369:Neoplasms / Q000532:radiotherapy*; D010386:Pelvic Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D017785:Photons / Q000627:therapeutic use; D061766:Proton Therapy / Q000379:methods / Q000706:statistics & numerical data / Q000639:trends; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012186:Retroperitoneal Neoplasms / Q000453:epidemiology / Q000532:radiotherapy; D012509:Sarcoma / Q000453:epidemiology / Q000532:radiotherapy
keywords: Cancer; Hadronthérapie; Particle therapy; Proton beam therapy; Protonthérapie; Radiotherapy; Radiothérapie