title: Implications of fundamental signalling alterations in diabetes mellitus-associated cardiovascular disease .
abstract: The chronic diabetes mellitus (DM) is a major risk factor for cardiovascular disease. The incidence of cardiovascular disease might be a foremost cause of morbidity and mortality in patients afflicted with DM. In fact, DM is associated with multi-factorial cardiovascular signalling alterations via significant modulation of expression pattern, activation or release of PI3K, PKB, eNOS, EDRF, NADPH oxidase, EDHF, CGRP, adenosine, iNOS, ROCK, PKC-β2, CaMKII, microRNA (miR)-126 and miR-130a, which could result in inadequate maintenance of cardiovascular physiology and subsequent development of cardiovascular pathology. This review highlights the possible adverse implications of fundamental cardiovascular signalling alteration in DM-associated cardiovascular disease pathology.
authors.forename: Pitchai
authors.initials: P
authors.lastname: Balakumar
mesh_terms: D000818:Animals; D003324:Coronary Artery Disease / Q000378:metabolism*; D048909:Diabetes Complications / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism*; D006801:Humans; D008955:Models, Cardiovascular; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction; D018487:Ventricular Dysfunction, Left / Q000378:metabolism*
chemical_list: D020543:Proteome