title: Combined angiotensin receptor blockade and neprilysin inhibition attenuates angiotensin-II mediated renal cellular collagen synthesis.
authors.affiliation: Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia.
authors.forename: Bing H
authors.initials: BH
authors.lastname: Wang
authors.affiliation: Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia; Department of Cardiology B, Oslo University Hospital Ullevål, 0407 Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Norway.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: von Lueder
authors.affiliation: Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia; Department of Medicine, University of Melbourne, St Vincent's Hospital, Fitzroy, VIC 3068 Australia.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Kompa
authors.affiliation: Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia.
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.affiliation: Novartis Pharmaceuticals Corp., Development Franchise - Critical Care, East Hanover, USA.
authors.forename: Randy
authors.initials: R
authors.lastname: Webb
authors.affiliation: Novartis Pharma DS&E and Oncology, Drug Safety and Epidemiology, Basel, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Jordaan
authors.affiliation: Department of Cardiology B, Oslo University Hospital Ullevål, 0407 Oslo, Norway.
authors.forename: Dan
authors.initials: D
authors.lastname: Atar
authors.affiliation: Monash Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC 3004, Australia. Electronic address: henry.krum@monash.edu.
authors.forename: Henry
authors.initials: H
authors.lastname: Krum
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D015260:Neprilysin / Q000037:antagonists & inhibitors*
chemical_list: D057911:Angiotensin Receptor Antagonists; D000804:Angiotensin II; D003094:Collagen; D015260:Neprilysin
keywords: ARNi; Angiotensin; LCZ696; Natriuretic peptide; Neutral endopeptidase; Renal fibrosis