title: Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET.
abstract: Introduction. Alzheimer's disease (AD) causes progressive hippocampus dysfunctions leading to the impairment of learning and memory ability and low level of uptake rate of glucose in hippocampus. What is more, there is no effective treatment for AD. In this study, we evaluated the beneficial and protective effects of electroacupuncture in senescence-accelerated mouse prone 8 (SAMP8). Method. In the electroacupuncture paradigm, electroacupuncture treatment was performed once a day for 15 days on 7.5-month-old SAMP8 male mice. In the normal control paradigm and AD control group, 7.5-month-old SAMR1 male mice and SAMP8 male mice were grabbed and bandaged while electroacupuncture group therapy, in order to ensure the same treatment conditions, once a day, 15 days. Results. From the Morris water maze (MWM) test, we found that the treatment of electroacupuncture can improve the spatial learning and memory ability of SAMP8 mouse, and from the micro-PET test, we proved that after the electroacupuncture treatment the level of uptake rate of glucose in hippocampus was higher than normal control group. Conclusion. These results suggest that the treatment of electroacupuncture may provide a viable treatment option for AD.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences & Comparative Medical Center, Peking Union Medical College, Beijing 100021, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Gao
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Anping
authors.initials: A
authors.lastname: Xu
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Suhua
authors.initials: S
authors.lastname: Shi
authors.affiliation: Community Health Service Center of Dongcheng District, Beijing 100010, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100029, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Li
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