title: Enhancement of memory consolidation by the histone deacetylase inhibitor sodium butyrate in aged rats.
abstract: Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) immediately after training in a step-down inhibitory avoidance task produced an enhancement of memory consolidation that persisted across consecutive retention tests during 14 days in aged rats, while it did not significantly affect memory in young adults. Control aged and young adult rats showed comparable basal levels of memory retention. Our results suggest that HDACis can display memory-enhancing effects specific for aged animals, even in the absence of age-related memory impairment.
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; Cancer and Neurobiology Laboratory, University Hospital Experimental Research Center (CPE-HCPA), Federal University of Rio Grande do Sul 90035-003 Porto Alegre, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil. Electronic address: martina.blank@ufsc.br.
authors.forename: Martina
authors.initials: M
authors.lastname: Blank
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Werenicz
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Luciana Azevedo
authors.initials: LA
authors.lastname: Velho
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Diana F
authors.initials: DF
authors.lastname: Pinto
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil.
authors.forename: Ana Cláudia
authors.initials: AC
authors.lastname: Fedi
authors.affiliation: Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil.
authors.forename: Mark William
authors.initials: MW
authors.lastname: Lopes
authors.affiliation: Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil.
authors.forename: Tanara Vieira
authors.initials: TV
authors.lastname: Peres
authors.affiliation: Department of Biochemistry, Federal University of Santa Catarina, 88040-900 Florianópolis, Brazil.
authors.forename: Rodrigo Bainy
authors.initials: RB
authors.lastname: Leal
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil.
authors.forename: Arethuza S
authors.initials: AS
authors.lastname: Dornelles
authors.affiliation: Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul 90050-170 Porto Alegre, RS, Brazil; Cancer and Neurobiology Laboratory, University Hospital Experimental Research Center (CPE-HCPA), Federal University of Rio Grande do Sul 90035-003 Porto Alegre, Brazil; National Institute for Translational Medicine (INCT-TM), 90035-003 Porto Alegre, Brazil.
authors.forename: Rafael
authors.initials: R
authors.lastname: Roesler
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D020148:Butyric Acid / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D017208:Rats, Wistar
chemical_list: D056572:Histone Deacetylase Inhibitors; D020148:Butyric Acid
keywords: Epigenetics; Histone deacetylase; Inhibitory avoidance; Memory consolidation; Sodium butyrate