title: Pustular drug hypersensitivity syndrome due to allopurinol.
abstract: Allopurinol hypersensitivity syndrome (AHS) is a severe drug reaction. It is characterized by rash, fever, and internal organ involvement. It may present in different clinical forms. We present a case of acute generalized exanthematous pustulosis occurring as a manifestation of AHS.
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Chaker
authors.initials: C
authors.lastname: Ben Salem
authors.affiliation: Department of Dermatology, Farhat Hached University Hospital, Tunisia.
authors.forename: Wafa
authors.initials: W
authors.lastname: Saidi
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Sofiene
authors.initials: S
authors.lastname: Larif
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Neila
authors.initials: N
authors.lastname: Fathallah
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Raoudha
authors.initials: R
authors.lastname: Slim
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Sousse, Tunisia.
authors.forename: Houssem
authors.initials: H
authors.lastname: Hmouda
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000493:Allopurinol / Q000009:adverse effects*; D001706:Biopsy; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D033461:Hyperuricemia / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D006074:Gout Suppressants; D000493:Allopurinol
keywords: Allopurinol; hypersensitivity syndrome; pustulosis
references.citation: J Dermatol. 2012 Dec;39(12):1077-8
references.pmid: 22901319
references.citation: J Dermatol. 2013 Feb;40(2):118-22
references.pmid: 23216243
references.citation: Clin Pharmacol Ther. 1981 Aug;30(2):239-45
references.pmid: 7249508
references.citation: Ann Pharmacother. 2010 Oct;44(10):1681-2
references.pmid: 20841519
references.citation: Cutan Ocul Toxicol. 2011 Sep;30(3):243-4
references.pmid: 21345152
references.citation: Curr Opin Immunol. 2012 Dec;24(6):730-5
references.pmid: 23062470