title: Opioid-induced central immune signaling: implications for opioid analgesia.
abstract: Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll-like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted.
authors.affiliation: University of Colorado Boulder, Boulder, CO, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Grace
authors.forename: Steven F
authors.initials: SF
authors.lastname: Maier
authors.forename: Linda R
authors.initials: LR
authors.lastname: Watkins
mesh_terms: D000698:Analgesia / Q000009:adverse effects; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000276:immunology*; D004361:Drug Tolerance / Q000276:immunology*; D006801:Humans; D006930:Hyperalgesia / Q000139:chemically induced / Q000276:immunology; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology*; D051197:Toll-Like Receptor 4 / Q000276:immunology
chemical_list: D000701:Analgesics, Opioid; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4
keywords: P2X4 receptor; P2X7 receptor; TLR4; allodynia; hyperalgesia; opioid receptor
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