title: Extended Daily Dialysis Versus Continuous Renal Replacement Therapy for Acute Kidney Injury: A Meta-analysis.
abstract: BACKGROUND
  Extended daily dialysis (EDD) has been suggested as an effective renal replacement therapy for acute kidney injury. However, results from studies comparing EDD to continuous renal replacement therapy (CRRT) are inconclusive.
  
  
  METHODS
  A systematic review and meta-analysis was performed by searching in MEDLINE, EMBASE, the Cochrane Library, Google Scholar, and a Chinese database (SinsoMed).
  
  
  METHODS
  Patients with acute kidney injury.
  
  
  METHODS
  Randomized controlled trials (RCTs) and observational studies were included. EDD was defined as extended hemodialysis or hemodiafiltration for more than 6 but less than 24 hours per session using a conventional hemodialysis machine.
  
  
  METHODS
  Renal replacement therapy comparing EDD with CRRT.
  
  
  RESULTS
  Mortality, kidney recovery, and fluid removal.
  
  
  RESULTS
  We included 17 studies from 2000 to 2014: 7 RCTs and 10 observational studies involving 533 and 675 patients, respectively. Meta-analysis of RCTs showed no difference in mortality rates between EDD and CRRT (relative risk, 0.90; 95% CI, 0.74-1.11; P=0.3). However, EDD was associated with lower mortality risk compared with CRRT in observational studies (relative risk, 0.86; 95% CI, 0.74-1.00; P=0.05). There was no evidence of heterogeneity in RCTs (I(2)=0%) or observational studies (I(2)=15%). In both RCTs and observational studies, there were no significant differences in recovery of kidney function, fluid removal, or days in the intensive care unit, and EDD showed similar biochemical efficacy to CRRT during treatment (serum urea, serum creatinine, and serum phosphate).
  
  
  CONCLUSIONS
  The survival benefit of EDD is dependent on only observational studies and might have been affected by allocation or selection bias.
  
  
  CONCLUSIONS
  EDD is associated with similar outcomes to CRRT in RCTs. The finding that EDD is associated with a lower mortality rate relies on data from observational studies, which are potentially subject to allocation or selection bias, making further high-quality RCTs desirable.
authors.affiliation: Division of Nephrology, West China Hospital of Sichuan University, Sichuan, Chengdu, China; Division of Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: West China School of Medicine, Sichuan University, Sichuan, Chengdu, China.
authors.forename: Jiqiao
authors.initials: J
authors.lastname: Yang
authors.affiliation: Division of Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia.
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Eastwood
authors.affiliation: Division of Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia; Division of Intensive Care Unit, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Zhu
authors.affiliation: Division of Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia.
authors.forename: Aiko
authors.initials: A
authors.lastname: Tanaka
authors.affiliation: Division of Intensive Care Unit, Austin Health, Heidelberg, VIC, Australia. Electronic address: rinaldo.bellomo@austin.org.au.
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D003422:Critical Care / Q000379:methods*; D017583:Hemodiafiltration / Q000379:methods; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D006435:Renal Dialysis / Q000379:methods; D017582:Renal Replacement Therapy / Q000379:methods*; D016896:Treatment Outcome
keywords: Extended daily dialysis (EDD); acute kidney injury (AKI); acute renal failure (ARF); continuous renal replacement therapy (CRRT); fluid removal; hemodiafiltration; hemofiltration; kidney recovery; meta-analysis; mortality; prolonged intermittent dialysis; sustained low-efficiency dialysis/diafiltration (SLED), hemodialysis