title: Matrix Metalloproteinase-9 as a Novel Player in Synaptic Plasticity and Schizophrenia.
abstract: Recent findings implicate alterations in glutamate signaling, leading to aberrant synaptic plasticity, in schizophrenia. Matrix metalloproteinase-9 (MMP-9) has been shown to regulate glutamate receptors, be regulated by glutamate at excitatory synapses, and modulate physiological and morphological synaptic plasticity. By means of functional gene polymorphism, gene responsiveness to antipsychotics and blood plasma levels MMP-9 has recently been implicated in schizophrenia. This commentary critically reviews these findings based on the hypothesis that MMP-9 contributes to pathological synaptic plasticity in schizophrenia.
authors.affiliation: Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lepeta
authors.affiliation: Department of Molecular and Cellular Neurobiology, Nencki Institute, Warsaw, Poland l.kaczmarek@nencki.gov.pl.
authors.forename: Leszek
authors.initials: L
authors.lastname: Kaczmarek
mesh_terms: D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D017470:Receptors, Glutamate / Q000378:metabolism*; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*
chemical_list: D017470:Receptors, Glutamate; D020780:Matrix Metalloproteinase 9
keywords: extracellular matrix; glutamate; synaptic plasticity
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