title: Association Between Platelet to Lymphocyte Ratio and Saphenous Vein Graft Disease.
abstract: Atherosclerosis plays an important role in saphenous vein graft disease (SVGD). Previous trials showed that inflammatory blood cells play a role in this process. The platelet to lymphocyte ratio (PLR) has been proposed as a novel predictor for cardiovascular risk and indicator of atherosclerosis. The aim of this study was to assess the relationship between SVGD and PLR. A total of 220 patients with SVG were enrolled (n = 87 with SVGD and n = 133 with patent SVG). A ≥ 50% stenosis within the SVG was defined as clinically significant. Median PLR (P < .001) and mean platelet volume (MPV; P = .043) were significantly higher in patients with SVGD. Also, PLR showed significantly positive correlation with age of SVG (P < .05). Median age of SVGs was also higher in the SVGD group (P = .025). In multivariate logistic regression analyses, the PLR and MPV were independent predictors of SVGD. Using a cutoff level of 106.3, the PLR predicted SVGD with a sensitivity of 87.4% and a specificity of 80.3%. To the best of our knowledge, this study showed, for the first time, that PLR was independently associated with SVGD. Both PLR and MPV might predict SVGD.
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Çağrı
authors.initials: Ç
authors.lastname: Yayla
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey dru_canpolat@yahoo.com.
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.affiliation: Cardiology Clinic, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyel
authors.affiliation: Cardiology Clinic, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Kadriye Gayretli
authors.initials: KG
authors.lastname: Yayla
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Sadık Kadri
authors.initials: SK
authors.lastname: Açikgöz
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Fırat
authors.initials: F
authors.lastname: Özcan
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Turak
authors.affiliation: Cardiology Clinic, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doğan
authors.affiliation: Cardiology Clinic, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Yeter
authors.affiliation: Cardiology Clinic, Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Aydoğdu
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001792:Blood Platelets; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012501:Saphenous Vein / Q000503:physiopathology / Q000637:transplantation*; D016896:Treatment Outcome; D014421:Turkey; D014654:Vascular Patency
keywords: inflammation; platelet to lymphocyte ratio; saphenous vein graft disease