title: Lupus anticoagulants and anticardiolipin antibodies in Indian women with spontaneous, recurrent fetal loss.
abstract: Spontaneous and recurrent pregnancy loss are common complications of pregnancy resulting from varied causes including antiphospholipid syndrome (APS). Treatment of women with APS increases the chance of a subsequent successful pregnancy. The study aimed to find the prevalence of lupus anticoagulants (LA) and anticardiolipin antibodies (ACAs) in women with spontaneous/recurrent fetal loss and compare with women with normal obstetric history. Hundred women with spontaneous/recurrent fetal loss and 50 healthy pregnant controls were tested for LA by complete blood counts, Prothrombin time, Activated partial thromboplastin time (APTT), LA sensitive APTT and dilute Russell viper venom time (dRVVT) (screening and confirmatory) and ACAs (ELISA). LA was detected in 15 % patients using dRVVT confirmatory test and ACA in 5 %, all controls being negative. Twenty one % patients were detected by LA sensitive APTT (sensitivity 92.9 %, specificity 100 %) and 100 % with dRVVT screening test (sensitivity 98.8 %, specificity 100 %). We recommend that screening for antiphospholipid antibodies must be done in women with spontaneous/recurrent foetal loss even in the absence of other clinical manifestations using a combination of tests.
authors.affiliation: Department of Pathology, University College of Medical Sciences and GTB Hospital, Delhi, 110095 India.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Rawat
authors.affiliation: Department of Pathology, University College of Medical Sciences and GTB Hospital, Delhi, 110095 India.
authors.forename: Meera
authors.initials: M
authors.lastname: Sikka
authors.affiliation: Department of Pathology, University College of Medical Sciences and GTB Hospital, Delhi, 110095 India.
authors.forename: Usha
authors.initials: U
authors.lastname: Rusia
authors.affiliation: Department of OBG, University College of Medical Sciences and GTB Hospital, Delhi, 110095 India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
keywords: APTT; Anticardiolipin antibodies; Lupus anticoagulant; Recurrent pregnancy loss; dRVVT
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