title: Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome.
abstract: BACKGROUND
  Brain-derived neurotrophic factor (BDNF) is a well-established neurotrophin that plays a role in the pathophysiology of numerous psychiatric disorders. Many studies have investigated the serum BDNF levels in patients with schizophrenia. However, there are restricted data in the literature that compare the serum BDNF levels in patients with deficit and nondeficit syndromes. In this study, we aimed to compare the serum BDNF levels between schizophrenic patients with deficit or nondeficit syndrome and healthy controls.
  
  
  METHODS
  After fulfilling the inclusion and exclusion criteria, 58 patients with schizophrenia and 36 healthy controls were included in the study. The patients were grouped as deficit syndrome (N=23) and nondeficit syndrome (N=35) according to the Schedule for the Deficit Syndrome. Three groups were compared in terms of the sociodemographic and clinical variants and serum BDNF levels.
  
  
  RESULTS
  The groups were similar in terms of age, sex, body mass index, and smoking status. The serum BDNF levels in patients with deficit syndrome were significantly lower than those in healthy controls. In contrast, the serum BDNF levels in patients with nondeficit syndrome were similar to those in healthy controls.
  
  
  CONCLUSIONS
  This study suggests that decreased BDNF levels may play a role in the pathophysiology of schizophrenic patients with deficit syndrome. Nonetheless, additional studies using a larger patient sample size are needed to investigate the serum BDNF levels in schizophrenic patients with deficit syndrome.
authors.affiliation: Deparment of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey.
authors.forename: Esra Soydaş
authors.initials: ES
authors.lastname: Akyol
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Yakup
authors.initials: Y
authors.lastname: Albayrak
authors.affiliation: Department of Psychiatry, Biga State Hospital, Çanakkale, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Beyazyüz
authors.affiliation: Department of Biochemistry, Yenimahalle Education and Research Hospital, Ankara, Turkey.
authors.forename: Nurkan
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kuloglu
authors.affiliation: Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
keywords: biomarker; neurotrophin; psychosis
references.citation: Dev Neurobiol. 2010 Apr;70(5):304-22
references.pmid: 20186705
references.citation: Neurosci Lett. 2008 Jul 11;439(2):157-9
references.pmid: 18514407
references.citation: J Clin Psychiatry. 2003 Jun;64(6):663-7
references.pmid: 12823080
references.citation: Psychoneuroendocrinology. 2011 May;36(4):523-30
references.pmid: 20933336
references.citation: Biol Psychiatry. 1999 Aug 1;46(3):352-60
references.pmid: 10435200
references.citation: Schizophr Res. 2006 Sep;86(1-3):321-2
references.pmid: 16829047
references.citation: Nature. 1993 May 27;363(6427):350-3
references.pmid: 8497318
references.citation: Psychopharmacology (Berl). 2012 Jul;222(2):277-84
references.pmid: 22274000
references.citation: World J Biol Psychiatry. 2010 Sep;11(6):763-73
references.pmid: 20334574
references.citation: Psychiatry Res. 2002 Jul 31;110(3):249-57
references.pmid: 12127475
references.citation: J Psychiatr Res. 2006 Oct;40(7):664-8
references.pmid: 16386272
references.citation: Neurosci Lett. 2007 Jun 8;420(1):45-8
references.pmid: 17442489
references.citation: Neurosci Lett. 2011 Sep 8;502(1):37-40
references.pmid: 21798311
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jul;28(4):709-13
references.pmid: 15276697
references.citation: Neuropharmacology. 1998 Dec;37(12):1553-61
references.pmid: 9886678
references.citation: Psychiatry Clin Neurosci. 2010 Aug;64(4):341-57
references.pmid: 20653908
references.citation: Psychopharmacology (Berl). 2009 Dec;207(3):375-80
references.pmid: 19787338
references.citation: Schizophr Res. 2009 May;110(1-3):1-23
references.pmid: 19328655
references.citation: Schizophr Res. 2007 Mar;91(1-3):1-5
references.pmid: 17306505
references.citation: J Psychiatr Res. 2007 Dec;41(12):997-1004
references.pmid: 17095017
references.citation: J Biol Chem. 2005 Mar 25;280(12):11995-2001
references.pmid: 15659400
references.citation: Eur Arch Psychiatry Clin Neurosci. 2015 Feb;265(1):83-4
references.pmid: 25362578
references.citation: ISRN Psychiatry. 2012 Mar 01;2012:656274
references.pmid: 23738207
references.citation: Turk Psikiyatri Derg. 2006 Summer;17(2):115-27
references.pmid: 16755412
references.citation: Neurosci Lett. 2003 Nov 13;351(2):111-4
references.pmid: 14583394
references.citation: Psychiatry Res. 2014 Feb 28;215(2):268-73
references.pmid: 24377440
references.citation: Psychiatry Res. 1989 Nov;30(2):119-23
references.pmid: 2616682
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: Schizophr Res. 2005 May 1;74(2-3):263-70
references.pmid: 15722005
references.citation: J Psychiatr Res. 2007 Jan-Feb;41(1-2):31-5
references.pmid: 16546213
references.citation: Arch Gen Psychiatry. 2001 Feb;58(2):165-71
references.pmid: 11177118
references.citation: Mol Psychiatry. 2011 Sep;16(9):960-72
references.pmid: 20733577
references.citation: Neurobiol Aging. 2005 Jan;26(1):115-23
references.pmid: 15585351
references.citation: Neurosignals. 2008;16(2-3):183-93
references.pmid: 18253057
references.citation: Biol Psychiatry. 2008 Sep 15;64(6):527-32
references.pmid: 18571629
references.citation: J Neurosci Res. 2007 Oct;85(13):2813-23
references.pmid: 17387691
references.citation: Am J Psychiatry. 1988 May;145(5):578-83
references.pmid: 3358462
references.citation: Psychiatry Res. 2014 Dec 15;220(1-2):197-200
references.pmid: 25219612
references.citation: Nat Rev Neurosci. 2005 Aug;6(8):603-14
references.pmid: 16062169
references.citation: Neuron. 2003 Aug 28;39(5):735-8
references.pmid: 12948441
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Nov 13;33(8):1508-12
references.pmid: 19720106
references.citation: Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14702-7
references.pmid: 11724927
references.citation: Epidemiol Rev. 2008;30:1-14
references.pmid: 18806255
references.citation: Eur Psychiatry. 2009 Dec;24(8):493-500
references.pmid: 19553087
references.citation: World J Biol Psychiatry. 2010 Mar;11(2 Pt 2):251-5
references.pmid: 20218789
references.citation: Bioessays. 2007 Feb;29(2):116-9
references.pmid: 17226799
references.citation: Trends Neurosci. 2005 Sep;28(9):464-71
references.pmid: 16040136
references.citation: Prog Neurobiol. 2013 Jan;100:15-29
references.pmid: 23044468
references.citation: Neuroscience. 2013 Jun 3;239:271-9
references.pmid: 23380505
references.citation: Schizophr Res. 2008 Apr;101(1-3):58-66
references.pmid: 18289832
references.citation: Biol Psychiatry. 2009 Sep 15;66(6):549-53
references.pmid: 19368899