title: Wine and bone health: a review.
abstract: A light-to-moderate wine consumption has been shown to provide several beneficial effects on the skeletal system, including reduced risk of bone mass loss and fractures. Wine is rich in phenolic compounds, strong phytoestrogens and natural antioxidants, to which bone protection is mainly attributed. The objective of this review was to give an overview of the exact mechanisms by which wine consumption is involved in bone protection. We found a great variety of in vitro research on the beneficial effects of isolated wine phenolics on the skeletal system, with a significant lack of evidence of their in vivo effects. In addition, we found almost no studies investigating how wine, a mixture of these phenolics dissolved in ethanol, affects the skeletal system. Our results warrant further research on this interesting topic.
authors.affiliation: Orthopedic Clinic, Clinical Hospital Centre Split, Split, Croatia.
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Kutleša
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital Split, Spinciceva 1, 21000, Split, Croatia. danijelabudimir@gmail.com.
authors.forename: Danijela
authors.initials: D
authors.lastname: Budimir Mršić
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D014920:Wine
chemical_list: D010636:Phenols
keywords: Osteoblasts; Osteoporosis; Phenolics; Wine
references.citation: Curr Clin Pharmacol. 2007 May;2(2):145-53
references.pmid: 18690862
references.citation: Biol Pharm Bull. 2003 Apr;26(4):523-6
references.pmid: 12673036
references.citation: Am J Clin Nutr. 2009 Apr;89(4):1188-96
references.pmid: 19244365
references.citation: J Bone Miner Metab. 2011 Jan;29(1):15-22
references.pmid: 20458604
references.citation: Ann N Y Acad Sci. 2002 May;957:21-36
references.pmid: 12074959
references.citation: Br J Cancer. 2002 Mar 4;86(5):774-8
references.pmid: 11875742
references.citation: J Nutr. 2003 Nov;133(11):3592-7
references.pmid: 14608079
references.citation: Alcohol Clin Exp Res. 1996 May;20(3):572-8
references.pmid: 8727257
references.citation: J Am Coll Nutr. 2002 Dec;21(6):536-44
references.pmid: 12480799
references.citation: Am J Clin Nutr. 2011 Nov;94(5):1371-5
references.pmid: 21940596
references.citation: Am J Clin Nutr. 2000 Nov;72(5):1206-13
references.pmid: 11063451
references.citation: J Bone Miner Res. 2012 Sep;27(9):1872-8
references.pmid: 22549983
references.citation: Acta Biochim Pol. 2009;56(3):503-7
references.pmid: 19753332
references.citation: Front Biosci (Elite Ed). 2012 Jan 01;4:1505-12
references.pmid: 22201971
references.citation: Eur J Cancer Prev. 2012 Jan;21(1):103-8
references.pmid: 22001915
references.citation: Public Health Nutr. 2013 Apr;16(4):704-12
references.pmid: 22800300
references.citation: Biochem Pharmacol. 2003 Jan 1;65(1):35-42
references.pmid: 12473376
references.citation: Cell Tissue Res. 2005 Mar;319(3):383-93
references.pmid: 15688188
references.citation: Planta Med. 2010 Mar;76(5):407-11
references.pmid: 19937547
references.citation: Biochem Pharmacol. 2007 Feb 15;73(4):504-14
references.pmid: 17113042
references.citation: Bioorg Med Chem. 2005 Sep 1;13(17):5195-205
references.pmid: 15963727
references.citation: J Cell Biochem. 2004 May 15;92(2):285-95
references.pmid: 15108355
references.citation: Am J Clin Nutr. 2012 May;95(5):1261-9
references.pmid: 22456655
references.citation: Calcif Tissue Int. 1994 Jul;55(1):1-7
references.pmid: 7922782
references.citation: Inflamm Res. 2005 Apr;54(4):158-62
references.pmid: 15883738
references.citation: Menopause. 2012 Sep;19(9):974-9
references.pmid: 22922514
references.citation: Am J Clin Nutr. 2004 Jan;79(1):155-65
references.pmid: 14684412
references.citation: Bone. 2009 Sep;45(3):449-54
references.pmid: 19450718
references.citation: J Cardiovasc Pharmacol. 2009 Feb;53(2):116-20
references.pmid: 19188838
references.citation: Osteoporos Int. 2007 Mar;18(3):391-400
references.pmid: 17091218
references.citation: Planta Med. 2009 Dec;75(15):1567-72
references.pmid: 19598079
references.citation: Ann Oncol. 2013 Mar;24(3):807-16
references.pmid: 23104725
references.citation: Eur J Clin Nutr. 2011 Apr;65(4):526-32
references.pmid: 21326269
references.citation: BMC Womens Health. 2013 Sep 22;13:36
references.pmid: 24053784
references.citation: Metabolism. 2011 Mar;60(3):351-8
references.pmid: 20359726
references.citation: Biochem Biophys Res Commun. 2010 Oct 22;401(3):356-62
references.pmid: 20851107
references.citation: Mutat Res. 2012 Jan-Mar;750(1):60-82
references.pmid: 22108298
references.citation: JAMA. 1996 Dec 4;276(21):1747-51
references.pmid: 8940324
references.citation: Am J Epidemiol. 2000 Apr 15;151(8):773-80
references.pmid: 10965974
references.citation: J Appl Toxicol. 1999 Jan-Feb;19(1):39-45
references.pmid: 9989476
references.citation: J Womens Health. 1999 Jan-Feb;8(1):65-73
references.pmid: 10094083
references.citation: Phytomedicine. 2007 Dec;14(12):806-14
references.pmid: 17689939
references.citation: Annu Rev Nutr. 2000;20:561-93
references.pmid: 10940346
references.citation: Eur J Pharmacol. 2006 Dec 3;551(1-3):1-9
references.pmid: 17026990
references.citation: Am J Clin Nutr. 2004 May;79(5):727-47
references.pmid: 15113710
references.citation: J Cell Physiol. 2016 Mar;231(3):558-67
references.pmid: 25545964
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14138-43
references.pmid: 9391166
references.citation: South Med J. 2004 Jul;97(7):664-72
references.pmid: 15301124
references.citation: Am J Epidemiol. 1995 Sep 1;142(5):485-92
references.pmid: 7677127
references.citation: Osteoporos Int. 2007 May;18(5):593-602
references.pmid: 17318666
references.citation: Am J Clin Nutr. 2002 Jul;76(1):245-52
references.pmid: 12081842
references.citation: Physiol Res. 2010;59(4):599-604
references.pmid: 19929136
references.citation: PLoS One. 2014 May 13;9(5):e97177
references.pmid: 24824988
references.citation: Life Sci. 2000 Jan 14;66(8):663-73
references.pmid: 10680575
references.citation: Mol Nutr Food Res. 2009 Nov;53(11):1452-61
references.pmid: 19784998
references.citation: Exp Cell Res. 2009 Oct 15;315(17):2953-62
references.pmid: 19665018
references.citation: BMJ. 1993 Jun 5;306(6891):1506-9
references.pmid: 8518677
references.citation: Endocrinology. 2000 Oct;141(10):3657-67
references.pmid: 11014220
references.citation: J Clin Endocrinol Metab. 2001 Nov;86(11):5217-21
references.pmid: 11701680