title: Successful therapy with bevacizumab in a case of hereditary hemorrhagic telangiectasia.
abstract: Hereditary hemorrhagic telangiectasia (HHT), genetic disorder manifested by uncontrolled multisystem angiogenesis with epistaxis, gastrointestinal bleeding, iron-deficiency anaemia, and arteriovenous malformations (AVM) is often related with increased levels of vascular endothelial growth factor (VEGF). Bevacizumab, a VEGF inhibitor, reduces epistaxis, telangiectasias, and iron-deficiency anaemia. A case of a female patient with HHT and chronic gastrointestinal bleeding is presented. The patient required iron supplementation and multiple blood transfusions. Bevacizumab brought marked symptomatic improvement and allowed for transfusion-independence. It is intended to apply for approval of the indications for bevacizumab administration in HHT as the 'orphan drug'.
authors.affiliation: a Department of Internal Diseases ; Voivodship Hospital ; Opole , Poland.
authors.forename: J
authors.initials: J
authors.lastname: Kochanowski
authors.forename: M
authors.initials: M
authors.lastname: Sobieszczańska
authors.forename: S
authors.initials: S
authors.lastname: Tubek
authors.forename: M
authors.initials: M
authors.lastname: Żurek
authors.forename: J
authors.initials: J
authors.lastname: Pawełczak
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007501:Iron / Q000627:therapeutic use; D008875:Middle Aged; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D000068258:Bevacizumab; D007501:Iron
keywords: arteriovenosous malformations; bevacizumab; dosing; epistaxis; hereditary hemorrhagic telangiectasia (HHT); vascular endothelial growth factor (VEGF)
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