title: Maternal pregnancy weight gain and cord blood iron status are associated with eosinophilia in infancy.
abstract: OBJECTIVE
  Allergic disease is multifactorial in origin. Because iron nutrition affects immune responses and maternal pregnancy weight gain impairs fetal iron delivery while increasing fetal demands for growth, the study examined maternal pregnancy weight gain, newborn iron status and an index of atopic disease, infant eosinophilia.
  
  
  METHODS
  Within a larger prospective study of healthy newborns at risk for developing iron deficiency anemia, umbilical cord iron indicators were compared to infant eosinophil counts.
  
  
  RESULTS
  Infants who developed eosinophilia exhibited higher cord reticulocyte-enriched zinc protoporphyrin/heme ratio, P<0.05 and fewer cord ferritin values in the highest (best) quartile, P<0.05. If cord ferritin was in the upper three quartiles, the negative predictive value for infant eosinophilia was 90%. High maternal pregnancy weight gain predicted infant eosinophil counts, P<0.04, and contributed to cord ferritin predicting eosinophilia, P<0.003.
  
  
  CONCLUSIONS
  Poor fetal iron status may be an additional risk factor for infant eosinophilia.
authors.affiliation: 1] Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA [2] Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: R
authors.initials: R
authors.lastname: Weigert
authors.affiliation: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Dosch
authors.affiliation: 1] Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA [2] Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Bacsik-Campbell
authors.affiliation: 1] Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA [2] University of Cincinnati, Cincinnati, OH, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Guilbert
authors.affiliation: Harlow Center for Biological Psychology, University of Wisconsin, Madison, WI, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Coe
authors.affiliation: Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Kling
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood*; D004802:Eosinophilia / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D005312:Fetal Blood; D006418:Heme; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007501:Iron / Q000097:blood*; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011446:Prospective Studies; D011524:Protoporphyrins; D012307:Risk Factors; D015430:Weight Gain / Q000502:physiology*
chemical_list: D011524:Protoporphyrins; C017803:zinc protoporphyrin; D006418:Heme; D005293:Ferritins; D007501:Iron
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