title: Different postprandial lipid metabolism and insulin resistance between non-diabetic patients with and without coronary artery disease.
abstract: BACKGROUND
  Postprandial hyperlipidemia and hyperinsulinemia have been thought to play an important role in the development of atherosclerosis. Diabetes mellitus (DM) has an impact on lipid metabolism, however, little is known about the relationship between the postprandial lipid and glucose metabolism in normoglycemic patients with coronary artery disease (CAD).
  
  
  METHODS
  To compare the postprandial lipid and glucose metabolism in normoglycemic patients with and without CAD, a total of 36 normoglycemic patients: 19 patients with stable CAD (CAD group, age 60.2±11.3 years) and 17 patients without CAD (Non-CAD group, age 60.4±9.6 years) were loaded with a high-fat and high-glucose test meal, and the changes in serum level of the lipid and glucose parameters were monitored before and 0, 2, 4, and 6h later.
  
  
  RESULTS
  In the Non-CAD group, postprandial serum levels of triglycerides (TG) and remnant-like particle cholesterol increased significantly and reached peak levels at the 4th hour and decreased significantly at the 6th hour of observation, whereas those levels in CAD group kept rising during 6h of observation. Although there was no significant difference in the area under the curves (AUCs) for the postprandial plasma glucose levels between CAD and Non-CAD group, the AUCs for the postprandial plasma insulin and C-peptide levels were significantly higher in the CAD group than in the Non-CAD group. The AUCs for postprandial TG levels showed good correlation with those for postprandial plasma insulin and C-peptide levels (insulin: r=0.455, p<0.005; C-peptide: r=0.462, p<0.05).
  
  
  CONCLUSIONS
  These findings suggest that postprandial hyperlipidemia and hyperinsulinemia may have a close relationship in CAD patients without DM and might play an important role in the development of atherosclerosis even before the onset of diabetes.
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan. Electronic address: AkihiroNakamura0223@msn.com.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Nakamura
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Monma
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Shoko
authors.initials: S
authors.lastname: Kajitani
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kozu
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Ikeda
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Noda
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Sota
authors.initials: S
authors.lastname: Nakajima
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Endo
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: Department of Cardiology, Iwate Prefectural Central Hospital, Morioka, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Nozaki
mesh_terms: D000368:Aged; D019540:Area Under Curve; D050197:Atherosclerosis / Q000209:etiology; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000150:complications / Q000378:metabolism*; D059305:Diet, High-Fat; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D006949:Hyperlipidemias / Q000209:etiology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D013549:Sweetening Agents / Q000008:administration & dosage; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D013549:Sweetening Agents; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol; D005947:Glucose
keywords: Coronary artery disease; Hyperinsulinemia; Postprandial hyperlipidemia