title: Pentoxifylline-tocopherol-clodronate combination: A novel treatment for osteoradionecrosis of the temporal bone.
abstract: BACKGROUND
  Osteoradionecrosis (ORN) of the temporal bone is a complication of radiation therapy that is extremely challenging to manage.
  
  
  METHODS
  We report the case of a patient treated at our institution and present a review of the literature.
  
  
  RESULTS
  A 52-year-old woman presented with ORN of the temporal bone 20 years after radiation therapy for an ipsilateral parotid tumor. She failed conservative management, including serial debridements, oral and topical antibiotics/antifungals, and aural lavage. As an alternative to hyperbaric oxygen (HBO) and/or temporal bone resection, treatment with pentoxifylline-tocopherol-clodronate combination (PENTOCLO) was pursued and her condition improved dramatically.
  
  
  CONCLUSIONS
  This is the first document use of PENTOCLO to treat ORN of the temporal bone. PENTOCLO may represent an effective nonsurgical management option for ORN of the temporal bone.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: Jordan T
authors.initials: JT
authors.lastname: Glicksman
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: Sammy
authors.initials: S
authors.lastname: Khalili
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: Kevin
authors.initials: K
authors.lastname: Fung
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: Lorne S
authors.initials: LS
authors.lastname: Parnes
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
authors.forename: Sumit K
authors.initials: SK
authors.lastname: Agrawal
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004002:Clodronic Acid / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000188:drug therapy* / Q000209:etiology*; D010307:Parotid Neoplasms / Q000532:radiotherapy*; D010431:Pentoxifylline / Q000627:therapeutic use*; D013701:Temporal Bone / Q000187:drug effects*; D024505:Tocopherols / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D004338:Drug Combinations; C559761:pentoxifylline-tocopherol-clodronate; D004002:Clodronic Acid; D024505:Tocopherols; D010431:Pentoxifylline
keywords: osteoradionecrosis; pentoxifylline; pentoxifylline-tocopherol-clodronate combination (PENTOCLO); temporal bone