title: Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action?
abstract: Skeletal muscle insulin resistance, which increases the risk for developing various metabolic diseases, including type 2 diabetes, is a common metabolic disorder in obesity and aging. If potential treatments are to be developed to treat insulin resistance, then it is important to fully understand insulin signaling and glucose metabolism. While recent large-scale "omics" studies have revealed the acetylome to be comparable in size to the phosphorylome, the acetylation of insulin signaling proteins and its functional relevance to insulin-stimulated glucose transport and glucose metabolism is not fully understood. In this Mini Review we discuss the acetylation status of proteins involved in the insulin signaling pathway and review their potential effect on, and relevance to, insulin action in skeletal muscle.
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Diego, CA, 92093, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: LaBarge
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Diego, CA, 92093, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Migdal
authors.affiliation: Department of Orthopaedic Surgery, University of California, San Diego, CA, 92093, USA.|Biomedical Sciences Graduate Program, University of California, San Diego, CA, 92093, USA.
authors.forename: Simon
authors.initials: S
authors.lastname: Schenk
mesh_terms: D000107:Acetylation; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007328:Insulin
keywords: SIRT1/HDAC; acetyltransferase; deacetylase; insulin signaling; p300/CBP
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