title: Challenges and opportunities in designing clinical trials for neuromyelitis optica.
abstract: Current management of neuromyelitis optica (NMO) is noncurative and only partially effective. Immunosuppressive or immunomodulatory agents are the mainstays of maintenance treatment. Safer, better-tolerated, and proven effective treatments are needed. The perceived rarity of NMO has impeded clinical trials for this disease. However, a diagnostic biomarker and recognition of a wider spectrum of NMO presentations has expanded the patient population from which study candidates might be recruited. Emerging insights into the pathogenesis of NMO have provided rationale for exploring new therapeutic targets. Academic, pharmaceutical, and regulatory communities are increasingly interested in meeting the unmet needs of patients with NMO. Clinical trials powered to yield unambiguous outcomes and designed to facilitate rapid evaluation of an expanding pipeline of experimental agents are needed. NMO-related disability occurs incrementally as a result of attacks; thus, limiting attack frequency and severity are critical treatment goals. Yet, the severity of NMO and perception that currently available agents are effective pose challenges to study design. We propose strategies for NMO clinical trials to evaluate agents targeting recovery from acute attacks and prevention of relapses, the 2 primary goals of NMO treatment. Aligning the interests of all stakeholders is an essential step to this end.
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Brian G
authors.initials: BG
authors.lastname: Weinshenker
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Gerard
authors.initials: G
authors.lastname: Barron
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Jacinta M
authors.initials: JM
authors.lastname: Behne
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Bennett
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Peter S
authors.initials: PS
authors.lastname: Chin
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Bruce A C
authors.initials: BA
authors.lastname: Cree
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Jerome
authors.initials: J
authors.lastname: de Seze
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Armando
authors.initials: A
authors.lastname: Flor
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fujihara
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Benjamin
authors.initials: B
authors.lastname: Greenberg
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Sayumi
authors.initials: S
authors.lastname: Higashi
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: William
authors.initials: W
authors.lastname: Holt
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Volker
authors.initials: V
authors.lastname: Knappertz
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Michael
authors.initials: M
authors.lastname: Levy
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Angela T
authors.initials: AT
authors.lastname: Melia
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Palace
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Terry J
authors.initials: TJ
authors.lastname: Smith
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Sormani
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Katja
authors.initials: K
authors.lastname: Van Herle
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Susan
authors.initials: S
authors.lastname: VanMeter
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Pablo
authors.initials: P
authors.lastname: Villoslada
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Marc K
authors.initials: MK
authors.lastname: Walton
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Warren
authors.initials: W
authors.lastname: Wasiewski
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Dean M
authors.initials: DM
authors.lastname: Wingerchuk
authors.affiliation: From the Department of Neurology (B.G.W.), Mayo Clinic, Rochester, MN; MedImmune Ltd. (G.B., A.F.), Riverside Building, Granta Park, Great Abington, Cambridge, UK; Guthy-Jackson Foundation (J.M.B., K.V.H.), San Diego, CA; Departments of Neurology and Ophthalmology (J.L.B.), University of Colorado Denver, Aurora; Novartis Pharmaceuticals Corporation (P.S.C.), East Hanover, NJ; Department of Neurology (B.A.C.C.), University of California San Francisco; CIC (Clinical Investigation Center) INSERM and UMR 1119 (J.d.S.), INSERM, Federation de Medecine Translationelle de Strasbourg, Université de Strasbourg; Department of Multiple Sclerosis Therapeutics (K.F.), Tohoku University, Sendai, Japan; Department of Neurology (B.G.), University of Texas Southwestern; Chugai Pharma USA (S.H., A.T.M.), Berkeley Heights, NJ; PPD Inc. (W.H.), Wilmington, NC; Department of Neurology (O.K.), Wayne State University, Detroit, MI; Teva Pharmaceuticals (V.K.), Frazer, PA; Department of Neurology (V.K.), Heinrich-Heine University, Dusseldorf, Germany; Department of Neurology (M.L.), Johns Hopkins University, Baltimore, MD; Department of Neurology (J.P.), Oxford University Hospital Trust, UK; Department of Ophthalmology and Visual Sciences (T.J.S.), Kellogg Eye Center, and Division of Metabolism, Endocrine, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor; Department of Health Science (M.P.S.), University of Genoa, Italy; David Geffen School of Medicine at UCLA (K.V.H.), Los Angeles, CA; GlaxoSmithKline (S.V.), Research Triangle Park, NC; Center of Neuroimmunology (P.V.), Institute of Biomedical Research August Pi Sunyer (IDIBAPS)-Hospital Clinic Barcelona, Villarroel, Spain; United States Food and Drug Administration (M.K.W.), Center for Drug Evaluation and Research, Silver Spring, MD; Alexion Pharmaceuticals Inc. (W.W.), Cheshire, CT; Department of Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Department of Medicine (M.R.Y.), Divisions of M
authors.forename: Michael R
authors.initials: MR
authors.lastname: Yeaman
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D006801:Humans; D009471:Neuromyelitis Optica / Q000188:drug therapy*; D012107:Research Design / Q000592:standards*
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