title: Maternal serum progesterone-induced blocking factor (PIBF) in the prediction of preterm birth.
abstract: The objective of this study was to analyze the maternal serum concentration of progesterone-induced blocking factor (PIBF) with regard to the prediction and the interval between sampling and the onset of preterm birth. A prospective study was conducted on a sample of 37 women with threatened pre-term birth and 41 healthy pregnant women between the 24th and 28th gestational weeks. Out of 37 patients with threatened preterm birth 11 delivered pre-term and three groups of patients were formed: the preterm delivery group, patients with threatened preterm delivery, and healthy pregnant women. In samples that were taken within 5 days before labor started (6/11, 54.5%), PIBF concentrations were significantly lower than in those obtained more than 5 days before labor (5/11, 45.5%; the mean interval between sampling and the onset of labor was 4.1 ± 1.8 days). Multiple regression analysis of the individual contributions of each observed parameter for preterm delivery demonstrated the significant contribution of a lack of PIBF to preterm birth (p = 0.002). Receiver operating characteristics (ROC) analysis was performed to evaluate the diagnostic accuracy of PIBF for the prediction of preterm birth of women with symptoms of pre-term delivery. The PIBF demonstrated an excellent diagnostic value in the prediction of preterm birth with an area under the ROC curve (AUC) of 0.956 (95% CI = 0.884-0.989; p < 0.0001). Our data suggest that pregnancy termination can be predicted by lower than normal pregnancy PIBF values within 5 days before labor and can contribute to the diagnosis of preterm birth.
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina. Electronic address: i.hudic@bih.net.ba.
authors.forename: Igor
authors.initials: I
authors.lastname: Hudić
authors.affiliation: Division of Obstetrics and Gynaecology, Rikshospitalet, Faculty of Medicine, University of Oslo, Oslo, Norway.
authors.forename: Babill
authors.initials: B
authors.lastname: Stray-Pedersen
authors.affiliation: Department of Medical Microbiology and Immunology, Pecs University, Medical School, Pecs, Hungary; Janos Szentagothai Research Centre, Pecs, Hungary; MTA-PTE Human Reproduction Scientific Research Group, Hungary.
authors.forename: Julia
authors.initials: J
authors.lastname: Szekeres-Bartho
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina.
authors.forename: Zlatan
authors.initials: Z
authors.lastname: Fatušić
authors.affiliation: Clinic for Internal Diseases, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.
authors.forename: Larisa
authors.initials: L
authors.lastname: Dizdarević-Hudić
authors.affiliation: Clinic for Gynecology and Obstetrics, University Hospital Mostar, Bosnia and Herzegovina.
authors.forename: Vajdana
authors.initials: V
authors.lastname: Tomić
authors.affiliation: Department of Medical Microbiology and Immunology, Pecs University, Medical School, Pecs, Hungary; Janos Szentagothai Research Centre, Pecs, Hungary; MTA-PTE Human Reproduction Scientific Research Group, Hungary.
authors.forename: Beata
authors.initials: B
authors.lastname: Polgar
authors.affiliation: School of Medicine, University of Tuzla, Bosnia and Herzegovina.
authors.forename: Bahrudin
authors.initials: B
authors.lastname: Hadžiefendić
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina.
authors.forename: Jasenko
authors.initials: J
authors.lastname: Fatušić
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D047928:Premature Birth / Q000097:blood*; D011446:Prospective Studies; D013491:Suppressor Factors, Immunologic / Q000097:blood*
chemical_list: C110058:PIBF1 protein, human; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic
keywords: Prediction; Preterm birth; Progesterone-induced blocking factor