title: Biological effects and mechanisms of action of mesenchymal stem cell therapy in chronic obstructive pulmonary disease.
abstract: Chronic obstructive pulmonary disease (COPD) is the most frequent chronic respiratory disease and a leading cause of morbidity and mortality, worldwide. Given that the foremost risk factor leading to the development of COPD is cigarette smoke, the initial treatment for COPD is smoking cessation. Even after smoking cessation, inflammation, apoptosis and oxidative stress can persist and continue to contribute to COPD. Although current therapies for COPD (which are primarily based on anti-inflammatory drugs such as corticosteroids, theophylline and bronchodilators) reduce airway obstruction, limit COPD exacerbation and improve the patient's health-related quality-of-life, none can prevent disease progression or reduce mortality. Recent advances in stem cell research have provided novel insight into the potential of bone marrow mesenchymal stem cells (MSCs) in the treatment of several pulmonary diseases. This review article discusses the biological effects and mechanisms of action of MSC transplantation in COPD, and highlights the foundation that MSCs provide for novel therapeutic approaches in COPD.
authors.affiliation: Second Department of Respiratory Medicine, The First People's Hospital of Kunming, Kunming, Yunnan Province, China.
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Stem Cell Engineering Laboratory of Yunnan Province, Department of Clinical Research, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan Province, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Pan
authors.affiliation: Second Department of Respiratory Medicine, The First People's Hospital of Kunming, Kunming, Yunnan Province, China.
authors.forename: Kaihua
authors.initials: K
authors.lastname: Zhou
authors.affiliation: Second Department of Respiratory Medicine, The First People's Hospital of Kunming, Kunming, Yunnan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Bi
authors.affiliation: Second Department of Respiratory Medicine, The First People's Hospital of Kunming, Kunming, Yunnan Province, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Pathology, The First People's Hospital of Kunming, Kunming, Yunnan Province, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
authors.affiliation: Second Department of Respiratory Medicine, The First People's Hospital of Kunming, Kunming, Yunnan Province, China Wangqing87329@126.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D064987:Cell- and Tissue-Based Therapy / Q000009:adverse effects / Q000379:methods*; D002908:Chronic Disease / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D059630:Mesenchymal Stem Cells; D018384:Oxidative Stress / Q000502:physiology; D029424:Pulmonary Disease, Chronic Obstructive / Q000628:therapy*; D012907:Smoking / Q000009:adverse effects
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents
keywords: Chronic obstructive pulmonary disease (COPD); emphysema; mesenchymal stem cell (MSC)