title: [RPN4 the yeast transcription factor promotes the complex defence against methyi, methanesulfonate].
abstract: Methyl methanesulfonate (MMS) is an alkylating agent commonly used in models of genotoxic stress. It methylates bases in DNA but also leads to oxidative stress. The transcription factor Rpn4 protects yeast cells from toxic effect of MMS. Although Rpn4 is a major regulator of ubiquitin-proteasome system (UPS), a number of data points to its participation in the stress response regardless of the UPS. We have demonstrated that under the methyl methanesulfonate stress Rpn4 promotes the regulation of several genes involved in DNA repair, antioxidant response and glucose metabolism. We suggest a mechanism of complex action of Rpn4 in the stress response.
authors.forename: D S
authors.initials: DS
authors.lastname: Spasskaia
authors.forename: D S
authors.initials: DS
authors.lastname: Karpov
authors.forename: A S
authors.initials: AS
authors.lastname: Mironov
authors.forename: V L
authors.initials: VL
authors.lastname: Karpov
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D008741:Methyl Methanesulfonate / Q000493:pharmacokinetics*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D013312:Stress, Physiological / Q000187:drug effects* / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004268:DNA-Binding Proteins; C119430:RPN4 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025801:Ubiquitin; D008741:Methyl Methanesulfonate; D046988:Proteasome Endopeptidase Complex; D005947:Glucose