title: Mosaic nature of the mitochondrial proteome: Implications for the origin and evolution of mitochondria.
abstract: Comparative studies of the mitochondrial proteome have identified a conserved core of proteins descended from the α-proteobacterial endosymbiont that gave rise to the mitochondrion and was the source of the mitochondrial genome in contemporary eukaryotes. A surprising result of phylogenetic analyses is the relatively small proportion (10-20%) of the mitochondrial proteome displaying a clear α-proteobacterial ancestry. A large fraction of mitochondrial proteins typically has detectable homologs only in other eukaryotes and is presumed to represent proteins that emerged specifically within eukaryotes. A further significant fraction of the mitochondrial proteome consists of proteins with homologs in prokaryotes, but without a robust phylogenetic signal affiliating them with specific prokaryotic lineages. The presumptive evolutionary source of these proteins is quite different in contending models of mitochondrial origin.
authors.affiliation: Department of Biochemistry and Molecular Biology and Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, Halifax, NS, Canada B3H 4R2 m.w.gray@dal.ca.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Gray
mesh_terms: D020561:Alphaproteobacteria / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000502:physiology; D019143:Evolution, Molecular; D018014:Gene Transfer Techniques; D054629:Genome, Mitochondrial; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000502:physiology*; D010802:Phylogeny; D020543:Proteome; D013559:Symbiosis; D015003:Yeasts
chemical_list: D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D020543:Proteome
keywords: endosymbiont; mitochondria; phagotrophy; proteome; syntrophy
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