title: Effect of Huanshuai Recipe Oral Liquid ([characters: see text]) on renal dysfunction progression in patients with atherosclerotic renal artery stenosis.
abstract: OBJECTIVE
  To investigate the effect of Huanshuai Recipe Oral Liquid ([characters: see text], HSR) on retarding the progression of renal dysfunction in patients with atherosclerotic renal artery stenosis (ARAS).
  
  
  METHODS
  A total of 52 ARAS patients with the Chinese medicine (CM) syndrome of qi deficiency and blood stasis, phlegm and dampness retention were recruited and randomly assigned into the treatment group (36 cases) and the control group (16 cases). Both groups received a basic treatment (high-quality low-protein diet, blood pressure control, lipid-lowering, correcting the acidosis, etc.). In addition, the treatment group received 20 mL HSR and the control group received placebo, 3 times a day for 6 months. Renal function (serum creatinine, blood urea nitrogen and uric acid) and blood lipids (cholesterol, triglycerides and low density lipoprotein) were examined monthly. The estimated glomerular filtration rate (eGFR) and CM syndrome score were compared between groups.
  
  
  RESULTS
  After treatment, compared with the control group, the serum creatinine level, uric acid level and CM syndrome score of the treatment group were significantly decreased (P<0.05 or P<0.01), and the eGFR in the treatment group were significantly increased (P<0.05).
  
  
  CONCLUSIONS
  HSR can effectively improve the renal function and clinical symptoms of ARAS patients.
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Xiu-juan
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China. raoyisheng@163.com.
authors.forename: Xiang-rong
authors.initials: XR
authors.lastname: Rao
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Gai-hua
authors.initials: GH
authors.lastname: Zhang
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Dong-yan
authors.initials: DY
authors.lastname: Han
authors.affiliation: Department of Nephropathy, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Nephropathy, Beijing Fangshan Hospital of Traditional Chinese Medicine, Beijing, 102400, China.
authors.forename: Nan-nan
authors.initials: NN
authors.lastname: Zhang
authors.affiliation: Department of Nephropathy, The Second People's Hospital of Zhuhai, Zhuhai, Guangdong Province, 519000, China.
authors.forename: Xue-xia
authors.initials: XX
authors.lastname: Li
authors.affiliation: Department of Nephropathy, Beijing Miyun Hospital of Traditional Chinese Medicine, Beijing, 101500, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000368:Aged; D050197:Atherosclerosis / Q000188:drug therapy*; D018450:Disease Progression; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests; D008055:Lipids / Q000097:blood; D008297:Male; D012078:Renal Artery Obstruction / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D008055:Lipids; C553673:huanshuai
keywords: Chinese medicine; Huanshuai Recipe Oral Liquid; atherosclerotic renal artery stenosis; renal dysfunction
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