title: [The role of E-cadherin cell adhesion molecule in human ontogenesis in norm and pathology].
abstract: E-cadherin is one of the most important cell adhesion molecules, which plays a key role in embryogenesis and adult tissues under normal conditions and during tumor development. Molecules of E-cadherin are located at the epitheliocyte surface and take part in the adhesion contacts formation which are a characteristic feature of epithelial tissues. The role of E-cadherin is not only in the maintenance of intercellular adhesion, but also in provision of cell proliferation and differentiation through participation in the realization of a number of signaling pathways, the main of which is the canonical Wnt signaling pathway. This review provides basic information regarding the role of E-cadherin in human ontogenesis in norm and pathology.
authors.forename: Yu M
authors.initials: YM
authors.lastname: Zasadkevich
authors.forename: S V
authors.initials: SV
authors.lastname: Sazonov
mesh_terms: D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009024:Morphogenesis; D009369:Neoplasms / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015820:Cadherins