title: Advances in the diagnosis and treatment of vestibular disorders: psychophysics and prosthetics.
abstract: Although vestibular disorders are common and often disabling, they remain difficult to diagnose and treat. For these reasons, considerable interest has been focused on developing new ways to identify peripheral and central vestibular abnormalities and on new therapeutic options that could benefit the numerous patients who remain symptomatic despite optimal therapy. In this review, I focus on the potential utility of psychophysical vestibular testing and vestibular prosthetics. The former offers a new diagnostic approach that may prove to be superior to the current tests in some circumstances; the latter may be a way to provide the brain with information about head motion that restores some elements of the information normally provided by the vestibular labyrinth.
authors.affiliation: Department of Otology and Laryngology and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02114 Richard_lewis@meei.harvard.edu.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Lewis
mesh_terms: D006801:Humans; D019736:Prostheses and Implants / Q000639:trends*; D011601:Psychophysics; D015837:Vestibular Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D014722:Vestibule, Labyrinth / Q000503:physiopathology
references.citation: Arch Intern Med. 2009 May 25;169(10):938-44
references.pmid: 19468085
references.citation: J Neurophysiol. 1994 Mar;71(3):1222-49
references.pmid: 8201414
references.citation: Exp Brain Res. 2008 Apr;186(4):677-81
references.pmid: 18350283
references.citation: Hear Res. 1999 Jan;127(1-2):108-18
references.pmid: 9925022
references.citation: Neurology. 1995 Jan;45(1):42-4
references.pmid: 7824132
references.citation: Conf Proc IEEE Eng Med Biol Soc. 2011;2011:2277-9
references.pmid: 22254795
references.citation: Brain. 1984 Dec;107 ( Pt 4):1123-42
references.pmid: 6334543
references.citation: Laryngoscope. 2012 Jun;122(6):1342-52
references.pmid: 22460150
references.citation: J Neurophysiol. 2011 Jan;105(1):209-23
references.pmid: 21068266
references.citation: Neurology. 2000 Nov 28;55(10):1431-41
references.pmid: 11094095
references.citation: Curr Opin Otolaryngol Head Neck Surg. 2012 Oct;20(5):404-8
references.pmid: 22902415
references.citation: Curr Opin Neurol. 2013 Jun;26(3):248-53
references.pmid: 23591684
references.citation: J Neurophysiol. 2010 Feb;103(2):1066-79
references.pmid: 20018838
references.citation: IEEE Trans Neural Syst Rehabil Eng. 2013 Sep;21(5):830-9
references.pmid: 23649285
references.citation: Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1323-6
references.pmid: 22254560
references.citation: Adv Space Biol Med. 2005;10:105-64
references.pmid: 16101106
references.citation: J Vestib Res. 2011;21(6):323-30
references.pmid: 22348937
references.citation: Neurology. 2014 Jun 10;82(23):2120-6
references.pmid: 24814847
references.citation: Nature. 1999 Apr 15;398(6728):615-8
references.pmid: 10217143
references.citation: Front Neurol. 2014 Apr 29;5:66
references.pmid: 24808890
references.citation: J Neurophysiol. 2012 Sep;108(5):1511-20
references.pmid: 22673321
references.citation: Hear Res. 2011 Nov;281(1-2):74-83
references.pmid: 21888961
references.citation: IEEE Trans Biomed Eng. 2007 Jun;54(6 Pt 1):1005-15
references.pmid: 17554820
references.citation: J Assoc Res Otolaryngol. 2013 Dec;14(6):863-77
references.pmid: 24013822
references.citation: Otol Neurotol. 2013 Aug;34(6):974-9
references.pmid: 23714711
references.citation: Ann Biomed Eng. 2000 May;28(5):572-81
references.pmid: 10925955
references.citation: J Neurophysiol. 2012 Jul;108(2):390-405
references.pmid: 22514288
references.citation: J Neurol. 2009 Mar;256(3):333-8
references.pmid: 19225823
references.citation: J Neurosci. 1999 Jan 1;19(1):316-27
references.pmid: 9870961
references.citation: Front Neurol. 2012 Feb 20;3:17
references.pmid: 22363316
references.citation: J Neurophysiol. 2006 Jun;95(6):3783-97
references.pmid: 16554521
references.citation: Otolaryngol Head Neck Surg. 2014 Jun;150(6):1040-2
references.pmid: 24647642
references.citation: J Vestib Res. 2009;19(1-2):1-13
references.pmid: 19893191
references.citation: J Neurophysiol. 2008 Jul;100(1):140-53
references.pmid: 18417632
references.citation: Atten Percept Psychophys. 2010 May;72(4):871-84
references.pmid: 20436185
references.citation: J Neurophysiol. 1984 Jun;51(6):1236-56
references.pmid: 6737029
references.citation: Lancet Neurol. 2013 Jul;12(7):706-15
references.pmid: 23769597
references.citation: Otol Neurotol. 2005 Jan;26(1):74-81
references.pmid: 15699723
references.citation: IEEE Trans Neural Syst Rehabil Eng. 2013 Mar;21(2):319-28
references.pmid: 23476007
references.citation: Ann N Y Acad Sci. 2009 May;1164:19-28
references.pmid: 19645876
references.citation: PLoS One. 2013;8(5):e61862
references.pmid: 23671577
references.citation: PLoS One. 2013;8(10):e78767
references.pmid: 24147142
references.citation: Brain Res Cogn Brain Res. 2004 Dec;22(1):32-5
references.pmid: 15561498
references.citation: Exp Brain Res. 2009 Sep;198(2-3):221-31
references.pmid: 19352639
references.citation: Ann Neurol. 2003 Nov;54(5):615-24
references.pmid: 14595651
references.citation: J Neurosci. 2013 May 29;33(22):9530-5
references.pmid: 23719819
references.citation: Semin Neurol. 2013 Jul;33(3):276-85
references.pmid: 24057831
references.citation: Laryngoscope. 2011 May;121(5):1124-5
references.pmid: 21520135
references.citation: Neurology. 1989 Feb;39(2 Pt 1):272-5
references.pmid: 2783767
references.citation: J Neurosci. 1995 Dec;15(12):7757-68
references.pmid: 8613717
references.citation: Exp Brain Res. 2013 Aug;229(2):181-95
references.pmid: 23771587
references.citation: J Neurosci. 2012 Sep 26;32(39):13537-42
references.pmid: 23015443
references.citation: Otol Neurotol. 2002 Jul;23(4):483-7
references.pmid: 12170150
references.citation: Brain Res Rev. 2011 Jun 24;67(1-2):119-46
references.pmid: 21223979
references.citation: J Assoc Res Otolaryngol. 2013 Apr;14(2):233-48
references.pmid: 23355001
references.citation: J Neurol. 2009 Sep;256(9):1488-92
references.pmid: 19434443
references.citation: J Vestib Res. 2012;22(1):11-5
references.pmid: 22699148
references.citation: J Neurosci. 2013 Sep 18;33(38):14978-80
references.pmid: 24048826
references.citation: J Assoc Res Otolaryngol. 2013 Dec;14(6):905-15
references.pmid: 24077672
references.citation: IEEE Trans Neural Syst Rehabil Eng. 2011 Oct;19(5):588-98
references.pmid: 21859631
references.citation: J Neurol. 2008 Sep;255(9):1332-6
references.pmid: 18825437
references.citation: J Assoc Res Otolaryngol. 2013 Jun;14(3):331-40
references.pmid: 23423561
references.citation: IEEE Trans Biomed Eng. 2013 Jun;60(6):1685-92
references.pmid: 23358943
references.citation: J Neurophysiol. 2005 Jul;94(1):186-98
references.pmid: 15728767
references.citation: Nature. 1996 Oct 31;383(6603):770
references.pmid: 8893000
references.citation: Otolaryngol Clin North Am. 2009 Feb;42(1):71-7, ix
references.pmid: 19134491
references.citation: Trends Neurosci. 2012 Mar;35(3):185-96
references.pmid: 22245372
references.citation: Front Neurol. 2014 Nov 10;5:233
references.pmid: 25426098
references.citation: Exp Brain Res. 2012 May;218(3):389-400
references.pmid: 22349559
references.citation: Laryngoscope. 2013 Feb;123(2):484-91
references.pmid: 23070719
references.citation: Laryngoscope. 2012 Jun;122(6):1379-84
references.pmid: 22473616
references.citation: J Neurophysiol. 2005 Feb;93(2):643-55
references.pmid: 15456806
references.citation: Acta Otolaryngol. 1969 Oct;68(4):350-62
references.pmid: 5309166