title: Antibodies to BK virus in children prior to allogeneic hematopoietic cell transplant.
abstract: BK virus (BKV) is associated with kidney and bladder disease after hematopoietic cell transplantation (HCT) but less is known about the seroprevalence of pre-transplant antibodies to BKV in children. We measured BKV IgG antibody titers in 36 children before HCT. BKV IgG antibodies were detected in all 36 patients, with 28/36 (77.8%) developing BK viremia in the first 100 days. Pre-HCT BKV IgG antibody titers >1:40,960 were protective against later BK viremia ≥10,000 copies/ml. The seroprevalence of antibodies to BKV is high in children undergoing HCT and post-transplant BK viremia, which is associated with bladder and kidney injury, is common.
authors.affiliation: Division of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Laskin
authors.affiliation: Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Sullivan
authors.affiliation: Viracor-IBT Laboratories, Lee's Summit, Missouri.
authors.forename: Jeff
authors.initials: J
authors.lastname: Hester
authors.affiliation: Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Jens
authors.initials: J
authors.lastname: Goebel
authors.affiliation: Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Stella M
authors.initials: SM
authors.lastname: Davies
authors.affiliation: Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
authors.forename: Sonata
authors.initials: S
authors.lastname: Jodele
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D001739:BK Virus / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D002648:Child; D003556:Cystitis / Q000209:etiology / Q000821:virology; D004198:Disease Susceptibility; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006417:Hematuria / Q000209:etiology / Q000821:virology; D006801:Humans; D008297:Male; D027601:Polyomavirus Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D012306:Risk; D016036:Seroepidemiologic Studies; D019172:Transplantation Conditioning / Q000009:adverse effects; D014412:Tumor Virus Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D019562:Viral Load; D014766:Viremia / Q000453:epidemiology / Q000209:etiology; D014775:Virus Activation
chemical_list: D000914:Antibodies, Viral
keywords: BK virus; hematopoietic cell transplant; humoral immunity; pediatrics
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