title: Modification of nitrate uptake pathway in plants affects the cadmium uptake by roots.
abstract: NRT1.1 is a dual-affinity nitrate (NO3(-)) transporter involved in both high- and low-affinity NO3(-) uptake in Arabidopsis plants. In a recent study, we showed that, under cadmium (Cd) exposure, blocking the NRT1.1-mediated NO3(-) uptake reduces Cd entry into roots, thus lowing Cd levels in plants and improving plant growth. In addition, we also found that the Cd levels in edible parts of 11 Chinese cabbage (Brassica rapa L. ssp. pekinensis) cultivars correlated well with the NO3(-) uptake rates of their roots. These results suggested that the NO3(-) uptake of roots negatively regulate Cd uptake. Modification of NO3(-) uptake in crops by modulating NO3(-) uptake pathway might provide a biological engineering approach to reducing Cd accumulation in edible organs, thus improving food safety.
authors.affiliation: a College of Natural Resources and Environmental Science; Zhejiang University ; Hangzhou , China.
authors.forename: Mei Yan
authors.initials: MY
authors.lastname: Guan
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Fan
authors.forename: Xian Zhi
authors.initials: XZ
authors.lastname: Fang
authors.forename: Chong Wei
authors.initials: CW
authors.lastname: Jin
mesh_terms: D027321:Anion Transport Proteins / Q000378:metabolism*; D017360:Arabidopsis / Q000378:metabolism*; D029741:Brassica rapa / Q000378:metabolism; D002104:Cadmium / Q000378:metabolism*; D017136:Ion Transport; D026901:Membrane Transport Proteins / Q000378:metabolism; D009566:Nitrates / Q000378:metabolism*; D009584:Nitrogen / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D018517:Plant Roots / Q000378:metabolism*
chemical_list: D027321:Anion Transport Proteins; D026901:Membrane Transport Proteins; C101492:NRT1.1 protein, Arabidopsis; D009566:Nitrates; D010940:Plant Proteins; D002104:Cadmium; D009584:Nitrogen
keywords: cadmium; nitrate transporter; nitrate uptake; nitrogen form
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