title: IgG4-related disease mimicking chalazion in the upper eyelid with skin manifestations on the trunk.
abstract: IgG4-related disease is a recently defined inflammatory process characterized by IgG4-bearing plasma cells in the involved tissues. The most common sites of involvement are the pancreas, hepatobiliary tract, salivary glands, lymph nodes, retroperitoneum and orbit, especially the lacrimal glands. Other ocular or ocular adnexal sites are rare. To our knowledge, there is one reported case of a conjunctival involvement. We describe a patient, who had an IgG4-RD mimicking chalazion in the upper eyelid, confined to the tarsus, with multiple skin lesions on the trunk. This is a case report of a 55-year-old female. A 55-year-old female presented with an upper eyelid lesion, which was clinically diagnosed as chalazion and drained three times. Histopathological diagnoses were chalazion and inflammation with mixed cells, respectively. Additionally, the patient had had skin nodules on the trunk for several years. Finally, after a third recurrence, the tarsal eyelid lesion was completely excised. The tarsal pathology specimen showed 85 IgG4 positive plasma cells per HPF and the IgG4/IgG ratio was 0.64, suggesting a probable IgG4-related disease. The re-examined skin lesions resembled histologically the eyelid lesion. It is essential to be aware of IgG4-related disease, including in recurrent chalazia.
authors.affiliation: Helsinki University Eye Hospital, PL 220, 00029 HUS, Helsinki, Finland, tiina.leivo@hus.fi.
authors.forename: Tiina
authors.initials: T
authors.lastname: Leivo
authors.forename: Sari
authors.initials: S
authors.lastname: Koskenmies
authors.forename: Marita
authors.initials: M
authors.lastname: Uusitalo
authors.forename: Olli
authors.initials: O
authors.lastname: Tynninen
mesh_terms: D017043:Chalazion / Q000276:immunology*; D003229:Conjunctival Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G
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