title: Incidence and survival of lacunar infarction in a southern Chinese population: A 7-year prospective study.
abstract: OBJECTIVE
  Little attention has been paid to the epidemiological characteristics of lacunar infarction (LAC) in China before. This study aimed to examine the incidence and survival of LAC in a southern Chinese population.
  
  
  METHODS
  From 2004-2010 in Changsha, two communities with a registered population of ∼100 000 were selected and data from first-ever ischaemic stroke (IS) cases were prospectively collected. Then the epidemiological characteristics of LAC and non-LAC were evaluated.
  
  
  RESULTS
  During the study period, the age-standardized incidence increased at an annual rate of 0.7% (p < 0.001) for LAC and 2.0% (p < 0.001) for non-LAC. The mean annual age-standardized incidence of LAC and non-LAC was 28.2/100 000 and 45.0/100 000, respectively. Compared with non-LAC patients, the prevalence of hypertension, diabetes and hyperlipidemia was significantly higher in patients with LAC (p < 0.05). Although the 30-day fatality rate was significantly lower in patients with LAC than non-LAC (0.5% vs. 14.9%, p < 0.001), there was no significant difference in survival between the two groups (96.7% vs. 95.2%, p = 0.203) after excluding the patients who died within 1 year of stroke onset.
  
  
  CONCLUSIONS
  LAC is a common stroke sub-type in southern China and the long-term prognosis is not benign.
authors.affiliation: Department of Neurology, the Second Hospital, Shanxi Medical University , Taiyuan, Shanxi Province , PR China .
authors.forename: Xin-Gang
authors.initials: XG
authors.lastname: Sun
authors.forename: Te
authors.initials: T
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: Yang
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D020520:Brain Infarction / Q000453:epidemiology / Q000401:mortality; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D059409:Stroke, Lacunar / Q000453:epidemiology* / Q000401:mortality
keywords: Incidence; lacunar infarct; risk factors; survival