title: Baseline predictors of visual acuity and retinal thickness in patients with retinal vein occlusion.
abstract: This study investigated the baseline predictors of best corrected visual acuity (BCVA) and central retinal thickness (CRT) at 6 months in patients with treatment-naïve branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO). This multicenter, interventional case series included 208 BRVO and 123 CRVO patients with follow-up period of 6 months or more. Outcome measures of BCVA (logMAR) included absolute change from baseline and a gain or loss of ≥ 0.3 from baseline. Outcome measures of CRT included absolute change from baseline and a measurement of ≤ 250 µm or ≥ 400 µm at 6 months. Univariate and multiple regression analyses were done to find baseline predictors. For BRVO, younger age, worse baseline BCVA, and shorter duration of symptom were associated with more gain in BCVA. For CRVO, worse baseline BCVA was associated with more gain in BCVA. For CRT outcomes, higher baseline CRT predicted greater decrease at 6 months in both BRVO and CRVO. Younger age and better baseline BCVA were associated with an increased likelihood of measurement of a ≤ 250 µm outcome for BRVO and CRVO, respectively. For CRVO, smoking was associated with greater decrease from baseline and decreased likelihood of measurement of a CRT ≥ 400 µm at 6 months. In conclusion, several baseline factors including age, symptom duration, and baseline BCVA and CRT are associated with BCVA and CRT outcomes at 6 months, which may help to predict disease course for RVO patients.
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sang Jin
authors.identifier: 0000-0002-1502-3155
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Asan Medical Center, University of Ulsan, Seoul, Korea.
authors.forename: Young Hee
authors.identifier: 0000-0002-2849-7528
authors.initials: YH
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea.
authors.forename: Ha Kyoung
authors.identifier: 0000-0002-5581-0057
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, St. Mary's Eye Clinic, Busan, Korea.
authors.forename: Hee Seong
authors.identifier: 0000-0001-9441-3057
authors.initials: HS
authors.lastname: Yoon
authors.affiliation: Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Se Woong
authors.identifier: 0000-0003-2095-6977
authors.initials: SW
authors.lastname: Kang
authors.affiliation: Department of Ophthalmology, Asan Medical Center, University of Ulsan, Seoul, Korea.
authors.forename: June-Gone
authors.identifier: 0000-0003-1181-941X
authors.initials: JG
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors.forename: Kyu Hyung
authors.identifier: 0000-0002-5516-8121
authors.initials: KH
authors.lastname: Park
authors.affiliation: Department of Ophthalmology, Chungnam National University Hospital, Deajeon, Korea.
authors.forename: Young Joon
authors.identifier: 0000-0002-1542-9841
authors.initials: YJ
authors.lastname: Jo
authors.affiliation: Department of Ophthalmology, Asan Medical Center, University of Ulsan, Seoul, Korea.
authors.forename: Dong-Hoon
authors.identifier: 0000-0002-7571-7749
authors.initials: DH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000473:pathology / Q000503:physiopathology*; D014792:Visual Acuity
keywords: Macular Edema; Retinal Vein Occlusion; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A; Visual Acuity
references.citation: Trans Am Ophthalmol Soc. 2000;98:133-41; discussion 141-3
references.pmid: 11190017
references.citation: Am J Ophthalmol. 1984 Sep 15;98(3):271-82
references.pmid: 6383055
references.citation: Am J Ophthalmol. 2008 May;145(5):841-6
references.pmid: 18321467
references.citation: Ophthalmology. 2009 Mar;116(3):497-503
references.pmid: 19167079
references.citation: Ophthalmology. 2009 Sep;116(9):1770-1777.e1
references.pmid: 19619896
references.citation: Arch Ophthalmol. 2009 Sep;127(9):1101-14
references.pmid: 19752419
references.citation: Arch Ophthalmol. 2009 Sep;127(9):1115-28
references.pmid: 19752420
references.citation: Ophthalmology. 2010 Jun;117(6):1124-1133.e1
references.pmid: 20381871
references.citation: Ophthalmology. 2010 Jun;117(6):1102-1112.e1
references.pmid: 20398941
references.citation: Ophthalmology. 2010 Jun;117(6):1113-1123.e15
references.pmid: 20430446
references.citation: Ophthalmology. 2010 Jun;117(6):1094-1101.e5
references.pmid: 20430447
references.citation: N Engl J Med. 2010 Nov 25;363(22):2135-44
references.pmid: 21105795
references.citation: Ophthalmology. 2011 Feb;118(2):345-52
references.pmid: 20926135
references.citation: Ophthalmology. 2011 Dec;118(12):2453-60
references.pmid: 21764136
references.citation: Br J Ophthalmol. 2012 Mar;96(3):380-5
references.pmid: 21733920
references.citation: J Korean Med Sci. 2013 Jan;28(1):136-44
references.pmid: 23341724