title: Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling.
abstract: Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.
authors.affiliation: Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA; and Department of Nutrition and Physiology and Ingestive Behavior, AgroParisTech, Paris, France.
authors.forename: Charlotte C
authors.initials: CC
authors.lastname: Ronveaux
authors.affiliation: Department of Nutrition and Physiology and Ingestive Behavior, AgroParisTech, Paris, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Tomé
authors.affiliation: Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, Davis, CA; and heraybould@ucdavis.edu.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Raybould
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating / Q000502:physiology*; D041981:Gastrointestinal Tract / Q000378:metabolism; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood* / Q000378:metabolism; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D020738:Leptin / Q000097:blood*; D009475:Neurons, Afferent / Q000378:metabolism*; D018027:Receptors, Glucagon / Q000378:metabolism; D012527:Satiation / Q000502:physiology; D015398:Signal Transduction
chemical_list: D001786:Blood Glucose; C000593833:GLP1R protein, human; D054439:Ghrelin; D000067757:Glucagon-Like Peptide-1 Receptor; D020738:Leptin; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1
keywords: food intake; ghrelin; glucagon-like peptide 1; leptin; vagal afferent neurons
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