title: γHV68 vGAT: a viral pseudoenzyme pimping for PAMPs.
abstract: In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses.
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kolakofsky
authors.affiliation: Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva 4, Switzerland. Electronic address: dominique.garcin@unige.ch.
authors.forename: Dominique
authors.initials: D
authors.lastname: Garcin
mesh_terms: D000818:Animals; D019733:Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor / Q000276:immunology*; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D018142:Gammaherpesvirinae / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000235:genetics*; D012367:RNA, Viral / Q000276:immunology*; D011971:Receptors, Immunologic; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D012367:RNA, Viral; D011971:Receptors, Immunologic; D014764:Viral Proteins; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D019733:Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; C022385:phosphoribosylformylglycinamidine synthetase