title: Collateral sensitivity of antibiotic-resistant microbes.
abstract: Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that caused multidrug resistance in bacteria simultaneously enhanced sensitivity to many other unrelated drugs (collateral sensitivity). Here, we explore how this emerging research sheds new light on resistance mechanisms and the way it could be exploited for the development of alternative antimicrobial strategies.
authors.affiliation: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary. Electronic address: cpal@brc.hu.
authors.forename: Csaba
authors.initials: C
authors.lastname: Pál
authors.affiliation: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Papp
authors.affiliation: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary.
authors.forename: Viktória
authors.initials: V
authors.lastname: Lázár
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics*; D019020:Directed Molecular Evolution; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D008826:Microbial Sensitivity Tests; D009154:Mutation; D017422:Sequence Analysis, DNA
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibiotic resistance; collateral sensitivity; cross-resistance; experimental evolution; multidrug resistance
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