title: Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus).
abstract: Class I sirtuin genes including SIRT1, SIRT2 and SIRT3, are members of the nicotinamide adenine dinucleotide (NAD)-dependent family of histone deacetylases, and play essential roles in senescence, metabolism, and apoptosis. This study was conducted to detect potential polymorphisms of the bovine class I sirtuin genes and explore their relationships with ultrasound carcass traits in Qinchuan cattle. Four non-coding mutations in the 3'UTR (SIRT1: g.25751A > C, SIRT1: g.25846A > G, SIRT2: g.19676G > A and SIRT3: g. 25702C > T) and three mutations in exons (SIRT2: g.4062C > T; SIRT2: g.4406C > T and SIRT3: g.25557A > G) were identified in 468 individuals of Qinchuan cattle. Chi-square tests showed that g.25751A > C, g.19676G > A, and g.25702C > T were in Hardy-Weinberg disequilibrium (χ(2) < χ0.05(2)). The statistical analyses indicated that six SNPs were significantly associated with the ultrasound carcass traits (P < 0.05) except g.4062C > T (SIRT2) (P > 0.05). These results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi 712100, PR China. Electronic address: 26660162@qq.com.
authors.forename: Linsheng
authors.initials: L
authors.lastname: Gui
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi 712100, PR China. Electronic address: hrjxx@126.com.
authors.forename: Ruijie
authors.initials: R
authors.lastname: Hao
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi 712100, PR China. Electronic address: 827136244@qq.com.
authors.forename: Yaran
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi 712100, PR China. Electronic address: 231708352@qq.com.
authors.forename: Xianlin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: College of Animal Science and Technology, Northwest A & F University, Yangling, Shaanxi 712100, PR China; National Beef Cattle Improvement Center of Northwest A & F University, Yangling, Shaanxi 712100, PR China. Electronic address: zanlinsen@163.com.
authors.forename: Linsen
authors.initials: L
authors.lastname: Zan
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001823:Body Composition; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002681:China; D056726:Genetic Association Studies; D006239:Haplotypes; D008460:Meat; D009130:Muscle, Smooth; D020641:Polymorphism, Single Nucleotide; D056564:Sirtuin 1 / Q000235:genetics*
chemical_list: D056564:Sirtuin 1
keywords: Association analysis; Class I sirtuins; Qinchuan cattle; Single nucleotide polymorphisms (SNP)