title: Physicochemical properties of potential porphyrin photosensitizers for photodynamic therapy.
abstract: This research evaluated the suitability of synthetic photosensitizers for their use as potential photosensitizers in photodynamic therapy using steady state and time-resolved spectroscopic techniques. Four tetraphenylporphyrin derivatives were studied in ethanol and dimethyl sulfoxide. The spectroscopic properties namely electronic absorption and emission spectra, ability to generate singlet oxygen, lifetimes of the triplet state, as well as their fluorescence quantum yield were determined. Also time-correlated single photon counting method was used to precisely determine fluorescence lifetimes for all four compounds. Tested compounds exhibit high generation of singlet oxygen, low generation of fluorescence and they are chemical stable during irradiation. The studies show that the tested porphyrins satisfy the conditions of a potential drug in terms of physicochemical properties.
authors.affiliation: Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland; A. Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. Electronic address: mmalkiewicz@us.edu.pl.
authors.forename: Marta
authors.initials: M
authors.lastname: Kempa
authors.affiliation: Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland; A. Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. Electronic address: pkozub@us.edu.pl.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Kozub
authors.affiliation: Department of Physics & Astronomy, Texas Christian University, Fort Worth, TX 76129, USA. Electronic address: j.d.kimball@tcu.edu.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kimball
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland. Electronic address: marcin.rojkiewicz@us.edu.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Rojkiewicz
authors.affiliation: Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland. Electronic address: pkus@ich.us.edu.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuś
authors.affiliation: Department of Physics & Astronomy, Texas Christian University, Fort Worth, TX 76129, USA. Electronic address: z.gryczynski@tcu.edu.
authors.forename: Zugmunt
authors.initials: Z
authors.lastname: Gryczyński
authors.affiliation: Silesian Center for Education and Interdisciplinary Research, 75 Pułku Piechoty 1A, 41-500 Chorzów, Poland; A. Chełkowski Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland. Electronic address: alicja.ratuszna@us.edu.pl.
authors.forename: Alicja
authors.initials: A
authors.lastname: Ratuszna
mesh_terms: D004121:Dimethyl Sulfoxide / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000431:Ethanol; D004121:Dimethyl Sulfoxide
keywords: Fluorescence lifetime; Photodynamic therapy; Porphyrin; Singlet oxygen; Triplet state lifetime