title: History of Mechanical Ventilation. From Vesalius to Ventilator-induced Lung Injury.
abstract: Mechanical ventilation is a life-saving therapy that catalyzed the development of modern intensive care units. The origins of modern mechanical ventilation can be traced back about five centuries to the seminal work of Andreas Vesalius. This article is a short history of mechanical ventilation, tracing its origins over the centuries to the present day. One of the great advances in ventilatory support over the past few decades has been the development of lung-protective ventilatory strategies, based on our understanding of the iatrogenic consequences of mechanical ventilation such as ventilator-induced lung injury. These strategies have markedly improved clinical outcomes in patients with respiratory failure.
authors.affiliation: 1 Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; and.
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Slutsky
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000266:history* / Q000517:prevention & control; D032761:Animal Experimentation / Q000266:history*; D000818:Animals; D003422:Critical Care / Q000266:history / Q000379:methods* / Q000639:trends; D005544:Forecasting; D049669:History, 16th Century; D049670:History, 17th Century; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D011051:Poliomyelitis / Q000150:complications / Q000266:history / Q000628:therapy; D011175:Positive-Pressure Respiration / Q000266:history / Q000379:methods; D012121:Respiration, Artificial / Q000009:adverse effects / Q000266:history* / Q000295:instrumentation / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000266:history / Q000628:therapy; D012131:Respiratory Insufficiency / Q000150:complications / Q000209:etiology / Q000628:therapy*; D012151:Resuscitation / Q000266:history* / Q000295:instrumentation / Q000379:methods; D014140:Tracheotomy / Q000266:history / Q000379:methods
keywords: ARDS; artificial respiration; history of medicine; iatrogenic; ventilators