title: [Effects of ozurdex on intraocular pressure. A real life clinical practice study].
abstract: OBJECTIVE
  The dexamethasone biodegradable implant, ozurdex, is approved by the US Food and Drug Administration and by the European Medical Agency for the treatment of intermediate and posterior uveitis, and for the treatment of macular edema following retinal vein occlusion and diabetic macular edema. The aim of this study was to assess the effects of intraocular pressure in a cohort of patients from a real-life clinical practice.
  
  
  METHODS
  Retrospective review was performed on the clinical records of patients treated with Ozurdex in Hospital Universitario Cruces in a 6 month period. The following variables were recorded: age, gender, diagnosis and history of glaucoma; intraocular pressure, antihypertensive treatment and macular thickness were recorded before the injection, and in the 1st, 2nd, 4th, and 6th months after the injection.
  
  
  METHODS
  Mann-Whitney U test, Chi square test (with Fisher correction when needed) and Wilcoxon test. The level of statistical significance was set at P<.05.
  
  
  RESULTS
  The effects of 75 injections given to 67 patients (35 women: 52%; mean age: 62) were evaluated. Mean intraocular pressure before the injection was 15.9 mmHg and at 1st, 2nd, 4th and 6th months after de injection it was 18.80 (P=.627), 18.84 (P=.494), 17.02 (P=.796) and 15.5 (P=.829), respectively. No statistically significant differences were observed in intraocular pressure measurements at the mentioned follow-up visits between patients with and without a history of glaucoma.
  
  
  CONCLUSIONS
  In real-life clinical practice, ozurdex shows an excellent safety profile in terms of intraocular hypertension. Patients with a history of glaucoma may also show this profile, with ozurdex being a good option to treat retinal diseases in these patients.
authors.affiliation: Sección de Retina y Uveítis, Hospital Universitario Cruces, Barakaldo, España. Electronic address: bjimenez003@gmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Jiménez-Gómez
authors.affiliation: Sección de Retina y Uveítis, Hospital Universitario Cruces, Barakaldo, España.
authors.forename: M
authors.initials: M
authors.lastname: González-Montpetit
authors.affiliation: Sección de Retina y Uveítis, Hospital Universitario Cruces, Barakaldo, España.
authors.forename: A
authors.initials: A
authors.lastname: Fonollosa Calduch
authors.affiliation: Sección de Retina y Uveítis, Hospital Universitario Cruces, Barakaldo, España.
authors.forename: A
authors.initials: A
authors.lastname: Orive Bañuelos
authors.affiliation: Sección de Retina y Uveítis, Hospital Universitario Cruces, Barakaldo, España.
authors.forename: S
authors.initials: S
authors.lastname: Valsero Franco
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003930:Diabetic Retinopathy / Q000188:drug therapy; D004343:Drug Implants; D005260:Female; D005901:Glaucoma / Q000150:complications; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D058449:Intravitreal Injections; D008269:Macular Edema / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000453:epidemiology; D012170:Retinal Vein Occlusion / Q000188:drug therapy; D012189:Retrospective Studies; D014065:Tonometry, Ocular
chemical_list: D000959:Antihypertensive Agents; D004343:Drug Implants; D003907:Dexamethasone
keywords: Glaucoma; Intraocular pressure; Ozurdex; Presión intraocular