title: Decaffeinated Green Tea and Voluntary Exercise Induce Gene Changes Related to Beige Adipocyte Formation in High Fat-Fed Obese Mice.
abstract: We have previously reported that decaffeinated green tea extract (GTE) in combination with voluntary exercise (Ex) reduces metabolic syndrome in high fat-fed C57BL/6J mice. Here, we examined for the first time the effect of treatment with 77 mg/g GTE, Ex, or both (GTE + Ex) on genes related to the conversion of white adipose tissue (WAT) to brown fat-like adipose tissue (BLAT) in this model. GTE+Ex induced genes related to lipolysis (hormone sensitive lipase [3.0-fold] and patatin-like phospholipase domain-containing protein 2 [2-fold]), mitochondrial β-oxidation (NADH dehydrogenase 5 [2.3-fold], cytochrome B [2.0-fold], and cytochrome C oxidase III [1.9-fold increase]), and adipose tissue browning (peroxisome proliferator-activated receptor-γ coactivator-1α [1.8-fold], bone morphogenetic protein 4 [2.6-fold], and phosphatase and tensin homolog [2.6-fold]) in visceral WAT compared to HF-fed mice. These results suggest that GTE+Ex function in part by inducing the conversion of WAT to BLAT and provides novel mechanistic insight into this combination.
authors.affiliation: Department of Food Science, The Pennsylvania State University, University Park, PA 16802.
authors.forename: Sudathip
authors.initials: S
authors.lastname: Sae-Tan
authors.affiliation: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802.
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Rogers
authors.affiliation: Department of Food Science, The Pennsylvania State University, University Park, PA 16802 ; Center For Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Lambert
keywords: Camellia sinensis; beige adipose tissue; green tea; obesity; voluntary exercise
references.citation: Mol Nutr Food Res. 2014 May;58(5):1156-9
references.pmid: 24375945
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807
references.pmid: 23388637
references.citation: Phytother Res. 2009 Aug;23(8):1088-91
references.pmid: 19107849
references.citation: Genes Dev. 2012 Feb 1;26(3):271-81
references.pmid: 22302939
references.citation: Ann Nutr Metab. 2009;54(2):151-7
references.pmid: 19390166
references.citation: Cell. 2012 Jul 20;150(2):366-76
references.pmid: 22796012
references.citation: IUBMB Life. 2004 Oct;56(10):595-600
references.pmid: 15814457
references.citation: Food Funct. 2011 Feb;2(2):111-6
references.pmid: 21779555
references.citation: Nature. 2012 Jan 11;481(7382):463-8
references.pmid: 22237023
references.citation: Obesity (Silver Spring). 2012 Nov;20(11):2311-3
references.pmid: 21633405
references.citation: Nature. 2007 Jun 21;447(7147):1012-6
references.pmid: 17554339
references.citation: FEBS Lett. 2010 Aug 4;584(15):3250-9
references.pmid: 20600006
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2563-8
references.pmid: 23359679
references.citation: Genes Dev. 2013 Feb 1;27(3):234-50
references.pmid: 23388824
references.citation: Am J Physiol Regul Integr Comp Physiol. 2005 Mar;288(3):R708-15
references.pmid: 15563575
references.citation: JAMA. 2010 Jan 20;303(3):235-41
references.pmid: 20071471
references.citation: Cell Metab. 2012 Mar 7;15(3):395-404
references.pmid: 22405074