title: Office-Based Photoangiolytic Laser Treatment of Reinke's Edema: Safety and Voice Outcomes.
abstract: OBJECTIVE
  To evaluate the safety, tolerability, and voice outcomes of office-based photoangiolytic laser treatment of Reinke's edema.
  
  
  METHODS
  Case series with chart review.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  We performed a retrospective analysis of patients undergoing office-based laser treatment of endoscopy-proven Reinke's edema. Safety and tolerability were evaluated by reviewing complications. Voice outcomes were analyzed by comparing pre- and postprocedural acoustic, aerodynamic, and Voice Handicap Index measurements. Complete data sets were not available for all subjects; sample size for each parameter is reported with the corresponding result.
  
  
  RESULTS
  Nineteen patients met inclusion criteria. There were no minor or major complications. Five procedures were truncated due to patient intolerance. Phonatory frequency range increased (n = 12, P = .003), while percent jitter decreased (n = 12, P = .004). Phonation threshold pressure decreased after treatment (n = 4, P = .049). Voice Handicap Index also decreased (n = 14, P < .001).
  
  
  CONCLUSIONS
  This study represents the largest series of patients undergoing office-based photoangiolytic laser treatment specifically for Reinke's edema. Our data suggest that this is a safe and effective modality to treat dysphonia associated with Reinke's edema, although patient intolerance of the procedure may represent a barrier.
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Koszewski
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Hoffman
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: W Greg
authors.initials: WG
authors.lastname: Young
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Ying-Ta
authors.initials: YT
authors.lastname: Lai
authors.affiliation: Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA dailey@surgery.wisc.edu.
authors.forename: Seth H
authors.initials: SH
authors.lastname: Dailey
mesh_terms: D000328:Adult; D000368:Aged; D000556:Ambulatory Surgical Procedures / Q000379:methods*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007431:Intraoperative Complications; D007819:Laryngeal Edema / Q000175:diagnosis / Q000601:surgery*; D007828:Laryngoscopy / Q000379:methods; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D061214:Patient Safety; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014827:Vocal Cords / Q000293:injuries; D014833:Voice Quality
keywords: Reinke’s edema; office-based treatment; photoangiolytic laser; voice