title: The utility of thromboelastometry in prophylactic platelet transfusion for hematological malignancies.
abstract: There is still debate on how platelet transfusions should be used to prevent severe bleeding. The aim of our study is to assess the clinical efficacy of thromboelastometry in reducing number of prophylactic platelet transfusions in patients with hematological malignancies. One hundred hematological malignancy patients were included in the study. Six units random donor platelets (RDPs) was given to the first group, three units RDPs was given to the second group, one unit single donor platelets (SDPs) was given to the third group, and 1/2 unit SDPs was given to the fourth group. Before and 15 minutes after transfusion, rotation thromboelastometry (ROTEM) was performed (Pentapharm GmbH, Munich, Germany). ROTEM(®) parameters did not show any statistical difference between 'low dose' and 'high dose' random or single donor platelet transfusions. Therefore, low dose platelet transfusion can be considered because of its reduced adverse transfusion reactions and economic burden.
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors.forename: Olga Meltem
authors.initials: OM
authors.lastname: Akay
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey. Electronic address: drdenizgoren@gmail.com.
authors.forename: Deniz
authors.initials: D
authors.lastname: Goren Sahin
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Andic
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors.forename: Eren
authors.initials: E
authors.lastname: Gunduz
authors.affiliation: Department of Hematology, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karagulle
authors.affiliation: Department of Biostatistics, Eskisehir Osmangazi University Medical School, Eskisehir, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Colak
authors.affiliation: Bone Marrow Transplantation Center, Anatolia Health Center, Gebze, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Gulbas
mesh_terms: D005260:Female; D019337:Hematologic Neoplasms / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion; D013916:Thrombelastography
keywords: Platelet; Thromboelastometry; Transfusion