title: Impact of cardiovascular complications among patients with Type 2 diabetes mellitus: a systematic review.
abstract: Macrovascular and microvascular complications that accompany Type 2 diabetes mellitus (T2DM) add to the burden among patients. The purpose of this systematic review is to conduct a comprehensive search of the medical literature investigating the prevalence of cardiovascular (CV) complications and assess their impact on healthcare costs, quality of life and mortality among patients with T2DM in the context of microvascular complications. A total of 76 studies and reports were used in this systematic review. Hypertension was the most prevalent complication among patients with T2DM. The additional cost burden due to CV complications was higher than any other complication except end-stage renal disease. Quality of life was much lower among patients with CV complications and T2DM, and mortality was higher than either illness alone.
authors.affiliation: Department of Pharmacy Practice, Pharmacy Health Care Administration, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Science Campus 3000 Arlington Ave., Toledo, OH 43614, USA.
authors.forename: Varun
authors.initials: V
authors.lastname: Vaidya
authors.forename: Nilesh
authors.initials: N
authors.lastname: Gangan
authors.forename: Jack
authors.initials: J
authors.lastname: Sheehan
mesh_terms: D002318:Cardiovascular Diseases / Q000191:economics / Q000453:epidemiology* / Q000209:etiology; D017281:Cost of Illness; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000191:economics / Q000401:mortality; D017048:Health Care Costs; D006801:Humans; D015995:Prevalence; D011788:Quality of Life
keywords: Type 2 diabetes mellitus; cardiovascular conditions; complications; healthcare costs; mortality; prevalence; quality of life