title: Nutritional status and clinical outcome in postterm neonates undergoing surgery for congenital heart disease.
abstract: OBJECTIVE
  Poor growth is a common complication in infants with congenital heart disease. There has been much focus on low birth weight as having increased risk of adverse outcomes following neonatal heart surgery. In this study, we examined whether preoperative nutritional status, measured by admission weight-for-age z score, was associated with postoperative clinical outcome.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Pediatric Cardiac ICU at the Royal Brompton Hospital.
  
  
  METHODS
  Neonates undergoing surgery for congenital heart disease. Those undergoing ductus arteriosus ligation alone were excluded. Children with coexisting noncardiac morbidity were excluded. Outcome variables included prevalence of postoperative complications (including sepsis, delayed chest closure, renal impairment, and necrotizing enterocolitis), duration of ventilation, intensive care stay, postoperative mortality, and mortality at 1 year after surgery.
  
  
  METHODS
  None. Analysis of patient data only.
  
  
  RESULTS
  Two hundred forty-eight neonates fulfilled the entry criteria. Median (interquartile range) age was 7 days (2-15 d), median (interquartile range) weight was 3.3 kg (2.91-3.6 kg), and median weight-for-age z score was -0.77 (-1.44 to 0.01). Twenty-eight children (11%) had a weight-for-age z score of less than -2. There was no evidence that children with lower weight-for-age z score had less severe surgery as measured by the Risk Adjustment for Congenital Heart Surgery 1 score. In multivariable regression analysis, the weight-for-age z at admission had strong correlation with the number of days free of respiratory support (invasive and noninvasive ventilation) at 28 days (p < 0.0001) and with all-cause mortality at 1 year (p = 0.001).
  
  
  CONCLUSIONS
  Poor nutritional status as measured by weight-for-age z is associated with adverse short- and long-term outcomes in neonates undergoing surgery for congenital heart disease.
authors.affiliation: 1Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom. 2Southampton University Hospital NHS Foundation Trust, Southampton, United Kingdom. 3Great Ormond Street Hospital, London, United Kingdom. 44Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Mitting
authors.forename: Luise
authors.initials: L
authors.lastname: Marino
authors.forename: Duncan
authors.initials: D
authors.lastname: Macrae
authors.forename: Nitin
authors.initials: N
authors.lastname: Shastri
authors.forename: Rosan
authors.initials: R
authors.lastname: Meyer
authors.forename: Nazima
authors.initials: N
authors.lastname: Pathan
mesh_terms: D001835:Body Weight; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality / Q000706:statistics & numerical data*; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D009752:Nutritional Status; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012307:Risk Factors