title: Medication use and predictors of sexual activity in men and women with CVD.
abstract: OBJECTIVE
  To examine the influence of cardiac and noncardiac medications on sexual activity by drug classification and generation of the drug, among men and women with cardiovascular disease.
  
  
  METHODS
  This study was a subanalysis (n = 224) of survey data from a cross-sectional sample of 336 cardiac patients. Self-reported medications were categorized by generic drug name, classification, and subclass and/or generation of the drug. Sexual activity was the presence or absence of current sexual activity in the last 2 months.
  
  
  CONCLUSIONS
  Patients taking generation one beta blockers, particularly men; diuretics as a class; and loop diuretics, were significantly less likely to be sexually active, with diuretics negatively influencing sexual activity in women, but not men. Certain antidepressant medications positively influenced sexual function, particularly for women. Nearly 20% of the variances in sexual activity were explained by younger age, fewer number of medications, higher education, and having a sexual partner.
  
  
  CONCLUSIONS
  A new finding meriting further study was that loop diuretics negatively impacted sexual activity, particularly for women; and further studies of women overall are clearly needed. Advance practice nurses play an important role in evaluating medications, proactively choosing drugs within a class or subclass less likely to cause sexual problems, and in promoting sexual quality of life of cardiac patients.
authors.affiliation: School of Nursing, Wichita State University, Wichita, Kansas.
authors.forename: Elaine E
authors.initials: EE
authors.lastname: Steinke
authors.affiliation: Department of Sociology, Wichita State University, Wichita, Kansas.
authors.forename: Twyla J
authors.initials: TJ
authors.lastname: Hill
authors.affiliation: School of Nursing, Wichita State University, Wichita, Kansas.
authors.forename: Victoria
authors.initials: V
authors.lastname: Mosack
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology; D012725:Sexual Behavior / Q000523:psychology*; D011795:Surveys and Questionnaires
keywords: Sexual intimacy; cardiovascular disease; medications; sexual health