title: Immunoglobulin G4-related disease in the urinary bladder.
abstract: Immunoglobulin G4-related disease is a fibroinflammatory condition of unclear etiology that can present with inflammatory changes and enlargement of a wide variety of organs, most commonly in the gastrointestinal tract. A diagnosis requires an elevated serum immunoglobulin G4 concentration and a tissue biopsy showing a dense plasma cell infiltrate with an increased percentage of immunoglobulin G4+ plasma cells. This disease infrequently presents in the genitourinary tract, and as such might be unfamiliar to and potentially overlooked by urologists. Here we present the third reported case of immunoglobulin G4-related disease manifesting as a mass in the urinary bladder.
authors.affiliation: Geisel School of Medicine at Dartmouth, Hanover, USA.
authors.forename: Benjamin M
authors.identifier: http://orcid.org/0000-0002-6105-610X
authors.initials: BM
authors.lastname: Dropkin
authors.affiliation: Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, USA.
authors.forename: Johann P
authors.initials: JP
authors.lastname: Ingimarsson
authors.affiliation: Geisel School of Medicine at Dartmouth, Hanover, USA.|Section of Rheumatology, Dartmouth-Hitchcock Medical Center, Lebanon, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Jones
authors.affiliation: Geisel School of Medicine at Dartmouth, Hanover, USA.|Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Pettus
authors.affiliation: Geisel School of Medicine at Dartmouth, Hanover, USA.|Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Seigne
mesh_terms: D000368:Aged; D005260:Female; D005355:Fibrosis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood*; D007155:Immunologic Factors / Q000627:therapeutic use; D007249:Inflammation / Q000097:blood / Q000473:pathology; D010950:Plasma Cells / Q000737:chemistry; D000069283:Rituximab / Q000627:therapeutic use; D001743:Urinary Bladder / Q000473:pathology*; D001745:Urinary Bladder Diseases / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007155:Immunologic Factors; D000069283:Rituximab
keywords: fibroinflammatory; immunoglobulin G; immunoglobulin G4-related disease; urinary bladder; urinary bladder neoplasm