title: Resolving sorting mechanisms into exosomes.
abstract: The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.
authors.affiliation: Utrecht University, Faculty of Veterinary Medicine, Dept. of Biochemistry & Cell Biology, Yalelaan 2, 3584 CM, The Netherlands.
authors.forename: Willem
authors.initials: W
authors.lastname: Stoorvogel
mesh_terms: D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D018797:Cell Cycle Proteins / Q000096:biosynthesis*; D056827:Endosomal Sorting Complexes Required for Transport / Q000096:biosynthesis*; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D053667:Syndecans / Q000096:biosynthesis*; D053676:Syntenins / Q000096:biosynthesis*
chemical_list: D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D053667:Syndecans; D053676:Syntenins; D005966:Glucuronidase
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