title: [Urinary biomarkers of kidney dysfunction].
abstract: The early diagnosis of chronic kidney disease (CKD) is based on the detection of markers of renal damage in urine collection. These urinary bio-markers are measurable before the appearance of functional defect, which is diagnosed with a decrease of glomerular filtration rate. Albuminuria, preferentially expressed as urinary albumin/creatinin ratio, is one of the marker of CKD. But today, other urinary biomarkers, monitoring tubulointersticial damage, are of interest in early diagnosis of CKD. In acute kidney injury, these markers could improve diagnostic tests, since they increase faster than serum creatinin. We propose a review of the urinary biomarkers of renal dysfunction used in routine clinical practice in 2015.
authors.affiliation: Laboratoire de biologie médicale, Centre hospitalier d'Avignon, Avignon, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Piéroni
authors.affiliation: Service de biochimie, CHU Lapeyronie, Montpellier, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000652:urine; D000419:Albuminuria / Q000175:diagnosis / Q000652:urine; D015415:Biomarkers / Q000652:urine*; D042241:Early Diagnosis; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000652:urine*; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis / Q000652:urine; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000652:urine
chemical_list: D015415:Biomarkers
keywords: albuminuria; kidney dysfunction; proteinuria; urinary biomarkers