title: Sepsis in head and neck cancer patients treated with chemotherapy and radiation: Literature review and consensus.
abstract: The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a review of recent literature in these topics.
authors.affiliation: Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: aurora.mirabile@gmail.com.
authors.forename: Aurora
authors.initials: A
authors.lastname: Mirabile
authors.affiliation: Medical Oncology Unit, Ospedale U. Parini, Viale Ginevra 3, 11100 Aosta, Italy. Electronic address: gnumico@ausl.vda.it.
authors.forename: Gianmauro
authors.initials: G
authors.lastname: Numico
authors.affiliation: Radiation Oncology Department, AO. S. Croce e Carle, Cuneo, Italy. Electronic address: elviorussi@gmail.com.
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Russi
authors.affiliation: Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: paolo.bossi@istitutotumori.mi.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bossi
authors.affiliation: Infectious Disease Department, AO.S. Paolo, Milano, Italy. Electronic address: fulvio.crippa@unimi.it.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Crippa
authors.affiliation: Radio-Oncology Department, IRCCS San Martino - IST, Largo R Benzi 10, 16132 Genoa, Italy. Electronic address: almalina.bacigalupo@hsanmartino.it.
authors.forename: Almalina
authors.initials: A
authors.lastname: Bacigalupo
authors.affiliation: Department of Radiotherapy, University "La Sapienza" Rome Italy. Electronic address: vitaliana.desanctis@uniroma1.it.
authors.forename: Vitaliana
authors.initials: V
authors.lastname: De Sanctis
authors.affiliation: Critical Care Department, AO S. Croce e Carle Cuneo, Italy. Electronic address: musso.s@ospedale.cuneo.it.
authors.forename: Stefania
authors.initials: S
authors.lastname: Musso
authors.affiliation: Radiation Oncology Department, Ospedale di Circolo di Busto Arsizio, Italy. Electronic address: anna.merlotti@virgilio.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Merlotti
authors.affiliation: Department of Oncology, Ospedale dell Angelo, Via Paccagnella 11, 30174 Mestre-Venezia, Italy. Electronic address: mariagraziaghi@yahoo.it.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Ghi
authors.affiliation: Medical Oncology Department, AO. S. Croce e Carle, Cuneo, Italy. Electronic address: mcmerlano@gmail.com.
authors.forename: Marco C
authors.initials: MC
authors.lastname: Merlano
authors.affiliation: Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy. Electronic address: Lisa.Licitra@istitutotumori.mi.it.
authors.forename: Lisa
authors.initials: L
authors.lastname: Licitra
authors.affiliation: Radiotherapy Department, AOU Città della Salute e della Scienza, Turin, Italy. Electronic address: moretto.francesco@hotmail.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Moretto
authors.affiliation: Medical Oncology Department, AO. S. Croce e Carle, Cuneo, Italy. Electronic address: nerinadenaro@gmail.com.
authors.forename: Nerina
authors.initials: N
authors.lastname: Denaro
authors.affiliation: Radiation Oncology Department, Isola Tiberina Fatebenefratelli Hospital, Rome, Italy. Electronic address: Fabriori@libero.it.
authors.forename: Orietta
authors.initials: O
authors.lastname: Caspiani
authors.affiliation: Radiation Oncology Department, University of Brescia and Spedali Civili, Brescia, Italy. Electronic address: michela.buglione@unibs.it.
authors.forename: Michela
authors.initials: M
authors.lastname: Buglione
authors.affiliation: Radiation Oncology Department, Unit of University of Messina, Italy. Electronic address: stpergolizzi@unime.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pergolizzi
authors.affiliation: Department of Human Pathology, University of Messina, Via Consolare Valeria n. 1, 98125 Messina, Italy. Electronic address: acascio@unime.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cascio
authors.affiliation: Department of Radio-Oncology, Genolier Clinic, Genolier and Geneva, Switzerland. Electronic address: jbernier@genolier.net.
authors.forename: Jacques
authors.initials: J
authors.lastname: Bernier
authors.affiliation: Department of Oral and Maxillofacial Surgery, Academic Medical Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: jraber@worldonline.nl.
authors.forename: Judith
authors.initials: J
authors.lastname: Raber-Durlacher
authors.affiliation: Department of Medical Oncology, Universitair Ziekenhuis Antwerpen, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: janb.vermorken@uza.be.
authors.forename: Jan B
authors.initials: JB
authors.lastname: Vermorken
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Vanderbilt University, Nashville, TN, USA. Electronic address: barbara.murphy@vanderbilt.edu.
authors.forename: Barbara
authors.initials: B
authors.lastname: Murphy
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, University of Turin, S. Giovanni Battista-Molinette Hospital, Turin, Italy. Electronic address: Marco.ranieri@unito.it.
authors.forename: Marco V
authors.initials: MV
authors.lastname: Ranieri
authors.affiliation: Cooper Medical School of Rowan University, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ, USA. Electronic address: Dellinger-Phil@CooperHealth.edu.
authors.forename: R Phillip
authors.initials: RP
authors.lastname: Dellinger
mesh_terms: D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D018805:Sepsis / Q000139:chemically induced / Q000453:epidemiology / Q000628:therapy
keywords: Chemotherapy; Head and neck cancer; Radiotherapy; Sepsis