title: Prevalence and immediate outcome of candida colonized preterm neonates admitted to Special Care Unit of Mulago Hospital, Kampala Uganda.
abstract: BACKGROUND
  Candida species is the third commonest cause of sepsis among neonates. Colonization by Candida is a predictor for candidemia among preterm neonates.
  
  
  OBJECTIVE
  To determine prevalence of early Candida colonization and early outcome among colonized preterm neonates admitted to Mulago hospital Special Care Unit.
  
  
  METHODS
  A prospective observational cohort was conducted between December 2008 and April 2009. Preterm neonates aged >72 hours and less than one week were screened for Candida colonization of the groin, oral pharynx and rectum using CHROMagar. Colonized neonates were followed up for 14 days. Blood cultures were done for those with signs of septicaemia. The Fisher's exact tests and logistic regression were conducted for factors associated with colonization and mortality among colonized neonates. P values of < 0.05 were considered significant and confidence interval of 95% was used.
  
  
  RESULTS
  Candida colonization occurred in 50/213 (23.5%) neonates. Gestational age ≤ 30 weeks was the only factor independently associated with colonization (p = 0.005). Of the colonized 14/46 (30.4%) died and 13/46 (28.3%) developed mucocutaneous candidiasis. No candidemia was identified. Multiple site colonization was independently associated with mortality (p=0.035).
  
  
  CONCLUSIONS
  The consequence of high colonization observed in this study needs to be further elucidated in Uganda.
authors.affiliation: Department of Paediatrics and Child Health, Makerere University College of Health Sciences.
authors.forename: Yaser
authors.initials: Y
authors.lastname: Abdallah
authors.affiliation: Department of Microbiology, Makerere University College of Health Sciences.
authors.forename: Deogratias
authors.initials: D
authors.lastname: Kaddu-Mulindwa
authors.affiliation: Department of Paediatrics and Child Health, Makerere University College of Health Sciences.
authors.forename: Jolly
authors.initials: J
authors.lastname: Nankunda
authors.affiliation: Department of Paediatrics and Child Health, Makerere University College of Health Sciences.
authors.forename: Philippa M
authors.initials: PM
authors.lastname: Musoke
mesh_terms: D002175:Candida / Q000254:growth & development / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D005260:Female; D005865:Gestational Age; D006784:Hospitals, Teaching; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000382:microbiology; D007363:Intensive Care Units, Neonatal; D008297:Male; D008403:Mass Screening; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000628:therapy; D012720:Severity of Illness Index; D014454:Uganda / Q000453:epidemiology
keywords: Candida colonization; Candidemia; Preterm neonates
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