title: Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery.
abstract: Gating of mesoporous silica nanoparticles (MSNs) with the stimuli-responsive poly(β-amino ester) has been achieved. This hybrid nanocarrier releases doxorubicin (DOX) under acidic conditions or in the presence of porcine liver esterase. The DOX loaded poly(β-amino ester)-capped MSNs reduce cell viability when tested on MDA-MB-231 human breast cancer cells.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA. stoddart@northwestern.edu.
authors.forename: Isurika R
authors.initials: IR
authors.lastname: Fernando
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Ferris
authors.forename: Marco
authors.initials: M
authors.lastname: Frasconi
authors.forename: Dmitry
authors.initials: D
authors.lastname: Malin
authors.forename: Elena
authors.initials: E
authors.lastname: Strekalova
authors.forename: M Deniz
authors.initials: MD
authors.lastname: Yilmaz
authors.forename: Michael W
authors.initials: MW
authors.lastname: Ambrogio
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Algaradah
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hong
authors.forename: Xinqi
authors.initials: X
authors.lastname: Chen
authors.forename: Majed S
authors.initials: MS
authors.lastname: Nassar
authors.forename: Youssry Y
authors.initials: YY
authors.lastname: Botros
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Cryns
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D004950:Esterases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013552:Swine
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; C509968:MCM-41; D011108:Polymers; C507253:poly(beta-amino ester); D012822:Silicon Dioxide; D004317:Doxorubicin; D004950:Esterases