title: Association of metabotropic glutamate receptor 3 gene polymorphisms with schizophrenia risk: evidence from a meta-analysis.
abstract: To date, the role of metabotropic glutamate receptor 3 (GRM3) rs274622, rs1468412, rs917071, rs6465084, and rs2299225 polymorphisms in schizophrenia remains controversial. To provide a clearer picture for the effect of the five most studied GRM3 polymorphisms on risk of schizophrenia, this meta-analysis with eligible data from published studies was performed. Relevant case-control studies were retrieved by literature search and selected according to established inclusion criteria. Odds ratios with 95% confidence intervals were used to assess the strength of association. A total of 33 individual studies were identified and included in our meta-analysis: nine for rs1468412, with 5,314 cases and 6,147 controls; six for rs917071, with 2,660 cases and 3,517 controls; seven for rs274622, with 3,820 cases and 4,015 controls; five for rs2299225, with 3,492 cases and 3,735 controls; and six for rs6465084, with 4,960 cases and 5,613 controls. However, no significant association was found between these GRM3 polymorphisms and schizophrenia in the overall population. With respect to rs1468412 polymorphism, a finding of very borderline statistical significance emerged in dominant comparison model for non-Asian populations, calling for large-scale verification to assess the marginally elevated risk of schizophrenia. In conclusion, these GRM3 polymorphisms have limited effect on the risks of schizophrenia. Further large and well-designed studies are needed to confirm this conclusion.
authors.affiliation: Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, People's Republic of China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, College of Health Sciences, Guangzhou Medical University, People's Republic of China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Forensic Medicine, School of Basic Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yue
keywords: GRM3; SNP; meta-analysis; schizophrenia
references.citation: Mol Psychiatry. 2005 Jan;10(1):40-68; image 5
references.pmid: 15263907
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 5;147(3):392-6
references.pmid: 17948896
references.citation: Neuropsychiatr Dis Treat. 2014 Jun 20;10:1133-9
references.pmid: 25018632
references.citation: Psychopharmacology (Berl). 2015 Jan;232(1):145-54
references.pmid: 25096017
references.citation: Schizophr Res. 2005 Sep 15;77(2-3):253-60
references.pmid: 15913960
references.citation: J Clin Invest. 2013 Nov;123(11):4557-63
references.pmid: 24177465
references.citation: Schizophr Res. 2005 Feb 1;73(1):21-6
references.pmid: 15567072
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12604-9
references.pmid: 15310849
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: PLoS One. 2014 Jan 31;9(1):e87247
references.pmid: 24498053
references.citation: Neuropsychobiology. 2009;59(3):142-50
references.pmid: 19439994
references.citation: Schizophr Res. 1999 Jul 27;38(1):71-5
references.pmid: 10427612
references.citation: Alcohol Alcohol. 2014 May-Jun;49(3):256-60
references.pmid: 24585043
references.citation: Schizophr Res. 2014 May;155(1-3):8-14
references.pmid: 24680030
references.citation: BMJ. 2003 Sep 6;327(7414):557-60
references.pmid: 12958120
references.citation: Annu Rev Pharmacol Toxicol. 2002;42:165-79
references.pmid: 11807169
references.citation: BMC Psychiatry. 2005 May 13;5:23
references.pmid: 15892884
references.citation: Psychiatr Genet. 2003 Jun;13(2):71-6
references.pmid: 12782962
references.citation: Psychiatr Genet. 2007 Dec;17(6):358
references.pmid: 18075480
references.citation: Brain Res Brain Res Rev. 2000 Mar;31(2-3):288-94
references.pmid: 10719155
references.citation: J Psychopharmacol. 2008 May;22(3):308-22
references.pmid: 18541626
references.citation: Psychiatry Clin Neurosci. 2008 Apr;62(2):239-40
references.pmid: 18412850
references.citation: J Natl Cancer Inst. 1959 Apr;22(4):719-48
references.pmid: 13655060
references.citation: Eur Neuropsychopharmacol. 2008 Oct;18(10 ):768-72
references.pmid: 18614340
references.citation: Schizophr Res. 2006 Dec;88(1-3):260-4
references.pmid: 16904291
references.citation: BMJ. 1997 Sep 13;315(7109):629-34
references.pmid: 9310563
references.citation: Arch Gen Psychiatry. 1995 Dec;52(12):998-1007
references.pmid: 7492260
references.citation: Arch Gen Psychiatry. 1998 Jan;55(1):67-74
references.pmid: 9435762
references.citation: Epidemiol Rev. 2008;30:67-76
references.pmid: 18480098
references.citation: Neurosci Lett. 2014 Nov 7;583:43-8
references.pmid: 25240594