title: Effect of Cyperus rotundus on ischemia-induced brain damage and memory dysfunction in rats.
abstract: OBJECTIVE
  Global cerebral ischemia-reperfusion injury causes loss of pyramidal cells in CA1 region of hippocampus. In this study, we investigated the possible neuroprotective effects of the ethanol extract of Cyperus rotundus (EECR) on a model of global transient ischemia in rat, by evaluating the pathophysiology of the hippocampal tissue and spatial memory.
  
  
  METHODS
  Treatment group (EECR, 100 mg/kg/day) was gavaged from 4 days before, to 3 days after ischemia. Morris water maze test was performed 1 week after ischemia for 4 days. Brain tissue was prepared for Nissl staining.
  
  
  RESULTS
  Our data showed no statistical difference between the treatment and ischemia groups in water maze task. So, treatment of ischemia with EECR cannot improve spatial learning and memory. On the contrary EECR ameliorated the CA1 pyramidal cell loss due to transient global ischemia/reperfusion injury.
  
  
  CONCLUSIONS
  These results suggest that EECR cannot reduce the ischemia-induced, cognitive impairments seen after transient, global cerebral ischemia but can prevent pyramidal cell loss in CA1 region of hippocampus.
authors.affiliation: Research Institute for Islamic and Complementary Medicine, Iran University of Medical Science, Tehran, Iran.
authors.forename: Fataneh Hashem
authors.initials: FH
authors.lastname: Dabaghian
authors.affiliation: Genetic Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Biology Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Entezari
authors.affiliation: Anatomy Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Movassaghi
authors.affiliation: Research Institute for Islamic and Complementary Medicine, Iran University of Medical Science, Tehran, Iran.
authors.forename: Seyed Ashrafadin
authors.initials: SA
authors.lastname: Goushegir
authors.affiliation: Biology Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Kalantari
authors.affiliation: School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Movafagh
authors.affiliation: Anatomy Department, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Zahra Nadia
authors.initials: ZN
authors.lastname: Sharifi
keywords: Cerebral ischemia; Cyperus rotundus; Morris water maze; Spatial memory
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