title: Plant NB-LRR proteins: tightly regulated sensors in a complex manner.
abstract: As plants are sessile, they have evolved hundreds of resistance (R) genes to defend themselves against multiple pathogens. Most of plant R genes encode proteins with the nucleotide-binding and leucine-rich repeat (NB-LRR) domains that interact with pathogen effectors to induce defense responses. Recent findings describing R proteins structures, host interactors and transcriptional and posttranscriptional regulators have broadened our understanding of R gene activity regulation. Genome-wide analyses of NB-LRR genes are useful for identifying host and nonhost R genes and elucidating complex resistance mechanisms. This review provides an overview of the functions of identified NB-LRRs and intra- and intermolecular R gene regulators.
authors.forename: Hyun-Ah
authors.initials: HA
authors.lastname: Lee
authors.forename: Seon-In
authors.initials: SI
authors.lastname: Yeom
mesh_terms: D015374:Biosensing Techniques; D018745:Genome, Plant; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D010940:Plant Proteins
keywords: NB-LRR; autoimmunity; effectors; regulatory mechanism; resistance genes