title: Eyelid myokymia in patients with migraine taking topiramate.
abstract: OBJECTIVE
  Although ocular side effects of topiramate are common, neuroophthalmologic manifestations such as blepharospasm, myokymia and oculogyric crisis are scarcely reported.
  
  
  METHODS
  We present a serie of 8 patients with migraine who developed eyelid myokymia after treatment with topiramate. We reviewed all patients with migraine treated with topiramate attending the headache outpatient clinic of our hospital from January 2008 to December 2012.
  
  
  RESULTS
  During the study period, a total of 140 patients with migraine were treated with topiramate in our headache clinic. Eight presented eyelid myokymia after beginning treatment with topiramate (5,7%). Topiramate was stopped and myokymia disappeared in all patients, it was prescribed again and eyelid myokymia reappeared with their previous characteristics in all patients.
  
  
  CONCLUSIONS
  Eyelid myokymia is an underreported side-effect of topiramate in patients with migraine, of unknown cause, so that in future, further studies are need to examine whether patients with migraine are predisposed or not to this adverse effect.
authors.affiliation: Department of Neurology, Hospital General Universitario Virgen De La Salud, Elda, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Medrano-Martínez
authors.affiliation: Department of Neurology, Hospital General Universitario De Alicante, Alicante, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pérez-Sempere
authors.affiliation: Department of Neurology, Hospital Verge Dels Lliris, Alcoi, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Moltó-Jordá
authors.affiliation: Department of Neurology, Hospital General Universitario Virgen De La Salud, Elda, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Fernández-Izquierdo
authors.affiliation: Department of Neurology, Hospital General Universitario Virgen De La Salud, Elda, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Francés-Pont
authors.affiliation: Department of Neurology, Hospital General Universitario Virgen De La Salud, Elda, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Mallada-Frechin
authors.affiliation: Department of Neurology, Hospital General Universitario Virgen De La Salud, Elda, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Piqueras-Rodríguez
mesh_terms: D000293:Adolescent; D000328:Adult; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D020385:Myokymia / Q000139:chemically induced*; D000077236:Topiramate
chemical_list: D000077236:Topiramate; D005632:Fructose
keywords: eyelid myokymia; isolated myokymia; migraine; neuro-ophthalmologic manifestations; ocular side effects; topiramate