title: Bioactive glass/hydroxyapatite composites: mechanical properties and biological evaluation.
abstract: Bioactive glass/hydroxyapatite composites for bone tissue repair and regeneration have been produced and discussed. The use of a recently developed glass, namely BG_Ca/Mix, with its low tendency to crystallize, allowed one to sinter the samples at a relatively low temperature thus avoiding several adverse effects usually reported in the literature, such as extensive crystallization of the glassy phase, hydroxyapatite (HA) decomposition and reaction between HA and glass. The mechanical properties of the composites with 80wt.% BG_Ca/Mix and 20wt.% HA are sensibly higher than those of Bioglass® 45S5 reference samples due to the presence of HA (mechanically stronger than the 45S5 glass) and to the thermal behaviour of the BG_Ca/Mix, which is able to favour the sintering process of the composites. Biocompatibility tests, performed with murine fibroblasts BALB/3T3 and osteocites MLO-Y4 throughout a multi-parametrical approach, allow one to look with optimism to the produced composites, since both the samples themselves and their extracts do not induce negative effects in cell viability and do not cause inhibition in cell growth.
authors.affiliation: Dipartimento di Ingegneria "E. Ferrari", Università di Modena and Reggio Emilia, Via P Vivarelli 10, 41125 Modena, Italy. Electronic address: devis.bellucci@unimore.it.
authors.forename: Devis
authors.initials: D
authors.lastname: Bellucci
authors.affiliation: Dipartimento di Ingegneria "E. Ferrari", Università di Modena and Reggio Emilia, Via P Vivarelli 10, 41125 Modena, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Sola
authors.affiliation: Laboratorio dei Biomateriali, Dipartimento di Scienze Mediche Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Anesi
authors.affiliation: Laboratorio dei Biomateriali, Dipartimento di Scienze Mediche Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Salvatori
authors.affiliation: Laboratorio dei Biomateriali, Dipartimento di Scienze Mediche Chirurgiche Materno-Infantili e dell'Adulto, Università di Modena e Reggio Emilia, Via Campi 213/A, 41125 Modena, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiarini
authors.affiliation: Dipartimento di Ingegneria "E. Ferrari", Università di Modena and Reggio Emilia, Via P Vivarelli 10, 41125 Modena, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Cannillo
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects*; D002516:Ceramics / Q000737:chemistry* / Q000633:toxicity*; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry* / Q000633:toxicity*; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry / Q000633:toxicity
chemical_list: C425330:bioactive glass 45S5; D017886:Durapatite
keywords: Bioglass; Cell culture; Composites; Cytotoxicity; Hydroxyapatite