title: [Misuse and abuse of quetiapine].
abstract: Quetiapine is an atypical antipsychotic agent, frequently used in psychiatry, often for symptomatic treatment against a number of mental disorders differing from the registration indications. One of the use is to soothe the clinical conditions caused by the use of various psychoactive substances. The paper presents and discusses the reports of quetiapine misuse, abuse, and even mental addiction, as well as symptoms similar to the so-called discontinuation syndrome, often mixed with withdrawal syndrome occurring in the course of addiction. Most reports concern males, and especially those with a history of other psychoactive substance abuse, and personality disorders, often in conflict with the law. Therefore, clinicians should be cautious when prescribing quetiapine to such patients. The article discusses potential mechanisms responsible for quetiapine abuse. This is probably related to its sedative and anxiolytic activity which results in the frequent use with stimulants. Also, high affinity for the H1 receptor, as antihistamines agents causes rewarding action.
authors.affiliation: Klinika Psychiatrii Dzieci i Młodzieży IPiN w Warszawie.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Piróg-Balcerzak
authors.affiliation: Zespół Profilaktyki i Leczenia Uzależnień IPiN w Warszawie.
authors.forename: Bogusław
authors.initials: B
authors.lastname: Habrat
authors.affiliation: Zakład Farmakologii i Fizjologii Układu Nerwowego IPiN w Warszawie.
authors.forename: Paweł
authors.initials: P
authors.lastname: Mierzejewski
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D063487:Prescription Drug Misuse / Q000706:statistics & numerical data*; D000069348:Quetiapine Fumarate; D012559:Schizophrenia / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000209:etiology*
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate
keywords: abuse; addiction; quetiapine