title: Intratumoral Heterogeneity: From Diversity Comes Resistance.
abstract: Tumors consist of a heterogeneous mixture of functionally distinct cancer cells. These functional differences can be caused by varying levels of receptor activity, differentiation, and distinct metabolic and epigenetic states. Intratumoral heterogeneity can lead to interdependence among different subpopulations of cells for sustained tumor growth. In addition, subpopulations can vary widely in their responses to therapeutic agents. As such, it is believed that intratumoral heterogeneity may underlie incomplete treatment responses, acquired and innate resistance, and disease relapse observed in the clinic in response to conventional chemotherapy and targeted agents.
authors.affiliation: Discovery Oncology, Genentech, Inc., South San Francisco, California.
authors.forename: Ariel
authors.initials: A
authors.lastname: Pribluda
authors.affiliation: Discovery Oncology, Genentech, Inc., South San Francisco, California.
authors.forename: Cecile C
authors.initials: CC
authors.lastname: de la Cruz
authors.affiliation: Discovery Oncology, Genentech, Inc., South San Francisco, California. jackson.erica@gene.com.
authors.forename: Erica L
authors.initials: EL
authors.lastname: Jackson
mesh_terms: D000818:Animals; D019008:Drug Resistance, Neoplasm; D044127:Epigenesis, Genetic; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology