title: Black soybean extract reduces fatty acid contents in subcutaneous, but not in visceral adipose triglyceride in high-fat fed rats.
abstract: It is known that black soybean (BS) extract, rich in polyphenols, has beneficial effects against obesity, inflammation and insulin resistance. However, detailed effects of BS on lipid metabolism have not been documented well. In the present study, we compared fatty acid composition in visceral and subcutaneous adipose tissues of high-fat fed (HFF) rats and BS administered HFF rats. Black soybean administration for 6 weeks influenced neither body nor adipose tissue weights, blood glucose, plasma insulin levels, or insulin sensitivity. However, BS reduced several saturated (C14:0 and C16:0), monounsaturated (C14:1n-5 and C18:1n-9) and n-6 polyunsaturated (C18:2n-6, C20:3n-6, C20:4n-6 and C22:4n-6) fatty acid contents in subcutaneous fat without any change in n-3 polyunsaturated fatty acid contents. No such effect was observed in fatty acid composition in visceral fat. Long-chain fatty acids are involved in regulation of inflammation. Therefore, those reduced fatty acids may be linked to the effects on suppressing inflammation.
authors.affiliation: Department of Biomedical Information Engineering, Graduate School of Medical Science, Yamagata University , Yamagata , Japan .
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sato
authors.forename: Masataka
authors.initials: M
authors.lastname: Kusunoki
authors.forename: Narumi
authors.initials: N
authors.lastname: Seino
authors.forename: Atsuyoshi
authors.initials: A
authors.lastname: Nishina
authors.forename: Zhonggang
authors.initials: Z
authors.lastname: Feng
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Takao
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D059808:Polyphenols / Q000494:pharmacology* / Q000627:therapeutic use; D017208:Rats, Wistar; D013025:Glycine max / Q000737:chemistry*; D050151:Subcutaneous Fat / Q000187:drug effects* / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides
keywords: Adipose tissue; black soybean extract; fatty acid composition; polyphenol