title: Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats.
abstract: Cognitive impairments severely affect the quality of life of patients who undergo brain irradiation, and there are no effective preventive strategies. In this study, we examined the therapeutic potential of electroacupuncture (EA) administered immediately after brain irradiation in rats. We detected changes in cognitive function, neurogenesis, and synaptic density at different time points after irradiation, but found that EA could protect the blood-brain barrier (BBB), inhibit neuroinflammatory cytokine expression, upregulate angiogenic cytokine expression, and modulate the levels of neurotransmitter receptors and neuropeptides in the early phase. Moreover, EA protected spatial memory and recognition in the delayed phase. At the cellular/molecular level, the preventative effect of EA on cognitive dysfunction was not dependent on hippocampal neurogenesis; rather, it was related to synaptophysin expression. Our results suggest that EA applied immediately after brain irradiation can prevent cognitive impairments by protecting against the early changes induced by irradiation and may be a novel approach for preventing or ameliorating cognitive impairments in patients with brain tumors who require radiotherapy.
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Xing-Wen
authors.initials: XW
authors.lastname: Fan
authors.affiliation: Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Fu
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Guan-Hao
authors.initials: GH
authors.lastname: Chen
authors.affiliation: Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University, Shanghai, China, 200032.
authors.forename: Huan-Huan
authors.initials: HH
authors.lastname: Liu
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
authors.forename: Shi-Kuo
authors.initials: SK
authors.lastname: Guan
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
authors.forename: Yun
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
authors.forename: Sheng-Jian
authors.initials: SJ
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032.
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Peng
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Jiang
authors.affiliation: Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China, 200032; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China, 200032.
authors.forename: Kai-Liang
authors.initials: KL
authors.lastname: Wu
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism / Q000528:radiation effects; D003071:Cognition / Q000528:radiation effects; D003072:Cognition Disorders / Q000517:prevention & control*; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D018891:Dentate Gyrus / Q000473:pathology / Q000528:radiation effects; D015671:Electroacupuncture; D008297:Male; D018782:Maze Learning; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D017207:Rats, Sprague-Dawley; D065852:Spatial Memory / Q000528:radiation effects; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D016207:Cytokines; D016708:Synaptophysin; C569016:Syp protein, rat
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