title: Selective Tumor Cell Inhibition Effect of Ni-Ti Layered Double Hydroxides Thin Films Driven by the Reversed pH Gradients of Tumor Cells.
abstract: Nitinol is widely fabricated as stents for the palliation treatment of many kinds of cancers. It is of great importance to develop nitinol stents with selective tumor cell inhibition effects. In this work, a series of pH sensitive films composed of Ni(OH)2 and Ni-Ti layered double hydroxide (Ni-Ti LDH) with different Ni/Ti ratios were prepared on the surface of nitinol via hydrothermal treatment. The films with specific Ni/Ti ratios would release a large amount of nickel ions under acidic environments but were relatively stable in neutral or weak alkaline medium. Cell viability tests showed that the films can effectively inhibit the growth of cancer cells but have little adverse effects to normal cells. Besides, extraordinarily high intracellular nickel content and reactive oxygen species (ROS) level were found in cancer cells, indicating the death of cancer cells may be induced by the excessive intake of nickel ions. Such selective cancer cell inhibition effect of the films is supposed to relate with the reversed pH gradients of tumor cells.
authors.affiliation: †State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Donghui
authors.initials: D
authors.lastname: Wang
authors.affiliation: ‡Intervention Center, Eastern Hepatobilialy Surgery Hospital, the Second Military Medical University, Shanghai 200438, China.
authors.forename: Naijian
authors.initials: N
authors.lastname: Ge
authors.affiliation: †State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Li
authors.affiliation: †State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: †State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Hongqin
authors.initials: H
authors.lastname: Zhu
authors.affiliation: †State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000497:Alloys / Q000008:administration & dosage* / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008567:Membranes, Artificial
chemical_list: D000497:Alloys; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; C013616:nitinol
keywords: Ni−Ti layered double hydroxide; cancer; nickel; nitinol; stent; tumor