title: Cytokines in the cerebrospinal fluids of patients with chronic fatigue syndrome/myalgic encephalomyelitis.
abstract: OBJECTIVE
  Previous research has provided evidence for dysregulation in peripheral cytokines in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). To date only one study has examined cytokines in cerebrospinal fluid (CSF) samples of CFS/ME patients. The purpose of this pilot study was to examine the role of cytokines in CSF of CFS/ME patients.
  
  
  METHODS
  CSF was collected from 18 CFS/ME patients and 5 healthy controls. The CSF samples were examined for the expression of 27 cytokines (interleukin- (IL-) 1β, IL-1ra, IL-2, IL-4, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17, basic FGF, eotaxin, G-CSF, GM-CSF, IFN-γ, IP-10, MCP-1 (MCAF), MIP-1α, MIP-1β, PDGF-BB, RANTES, TNF-α, and VEGF) using the Bio-Plex Human Cytokine 27-plex Assay.
  
  
  RESULTS
  Of the 27 cytokines examined, only IL-10 was significantly reduced in the CFS/ME patients in comparison to the controls.
  
  
  CONCLUSIONS
  This preliminary investigation suggests that perturbations in inflammatory cytokines in the CSF of CFS/ME patients may contribute to the neurological discrepancies observed in CFS/ME.
authors.affiliation: Simmaron Research, 948 Incline Way, Incline Village, NV 89451, USA.
authors.forename: D
authors.initials: D
authors.lastname: Peterson
authors.affiliation: Griffith Health Institute, School of Medial Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD 4222, Australia.
authors.forename: E W
authors.initials: EW
authors.lastname: Brenu
authors.affiliation: Simmaron Research, 948 Incline Way, Incline Village, NV 89451, USA.
authors.forename: G
authors.initials: G
authors.lastname: Gottschalk
authors.affiliation: Griffith Health Institute, School of Medial Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD 4222, Australia.
authors.forename: S
authors.identifier: 0000-0002-2065-1631
authors.initials: S
authors.lastname: Ramos
authors.affiliation: Griffith Health Institute, School of Medial Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD 4222, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Griffith Health Institute, School of Medial Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD 4222, Australia.
authors.forename: D
authors.identifier: 0000-0002-9647-9954
authors.initials: D
authors.lastname: Staines
authors.affiliation: Griffith Health Institute, School of Medial Sciences, National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Parklands, QLD 4222, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Marshall-Gradisnik
mesh_terms: D016022:Case-Control Studies; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D016207:Cytokines / Q000134:cerebrospinal fluid*; D015673:Fatigue Syndrome, Chronic / Q000134:cerebrospinal fluid*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D010865:Pilot Projects
chemical_list: D016207:Cytokines; D016753:Interleukin-10
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