title: [Application of a standardized-human biomonitoring methodology to assess prenatal exposure to mercury].
abstract: World Health Organization (WHO), in cooperation with the Consortium to Perform Human Biomonitoring on a European Scale (COPHES), has developed a standardized methodology for human biomonitoring (HBM) surveys in maternities in order to assess prenatal exposure to mercury. To test this standard methodology and adapt it to Russian settings, a cross-sectional HBM survey involving 120 parturient women was conducted in six maternities of the Moscow Region. Levels of total mercury in maternal hair (geometric mean: 0.21 μg/g, 95th percentile: 0.54 μg/g), cord blood (0.89 μg/L and 2.38 μg/L, respectively) and maternal urine (0.27 μg/L and 0.94 μg/L) in this population were similar to those in other European countries with relatively low fish consumption. Consumption of all types of fish at least once per week during the third trimester of pregnancy compared to fish consumption less than once per month was associated with the increase of geometric mean level of total mercury: in hair by 31% (95% confidence interval: 4%, 66%) higher, in cord blood--by 38% (9%, 74%) and in maternal urine--by 36% (2%, 81%). No biomarker values exceeded levels recommended by WHO or national agencies in the USA and Germany. However; at the population level, adverse effects of prenatal exposures to mercury can still be substantial.
authors.forename: A I
authors.initials: AI
authors.lastname: Egorov
authors.forename: I N
authors.initials: IN
authors.lastname: Ilchenko
authors.forename: S M
authors.initials: SM
authors.lastname: Lyapunov
authors.forename: E V
authors.initials: EV
authors.lastname: Marochkina
authors.forename: O I
authors.initials: OI
authors.lastname: Okina
authors.forename: B V
authors.initials: BV
authors.lastname: Ermolaev
authors.forename: T V
authors.initials: TV
authors.lastname: Karamysheva
mesh_terms: D004784:Environmental Monitoring / Q000379:methods / Q000592:standards; D005247:Feeding Behavior; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006197:Hair / Q000737:chemistry; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects; D008628:Mercury / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012426:Russia; D017747:Seafood; D011795:Surveys and Questionnaires; D014874:Water Pollutants, Chemical / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D014944:World Health Organization
chemical_list: D014874:Water Pollutants, Chemical; D008628:Mercury