title: [Evolution conservativity of scar DNA localization in warm-blooded vertebrates isochores].
abstract: In meiotic prophase I attached to the lateral elements of the synaptonemal complex chromatin fibrils form loops. SCARs DNA (Synaptonemal Complex Associated Regions of DNA) is a family of genomic DNA sequences tightly associated with the synaptonemal complex and lying at the loop basements. Isochore compositional fractions of the human and chicken genomes were used as 32P-labeled probes for hybridization with the SCARs DNA isolated previously from the spermatocyte nucleus of the golden hamster Mesocricetus auratus. The localization of sequences, similar to golden hamster SCARs DNA in the human and chicken genome isochores was established. It was concluded that SCARs DNA localization into isochore com- partments of examined genomes is evolutionary conservative.
authors.forename: T V
authors.initials: TV
authors.lastname: Sizova
authors.forename: O I
authors.initials: OI
authors.lastname: Karpova
mesh_terms: D000818:Animals; D002645:Chickens; D017124:Conserved Sequence; D006224:Cricetinae; D019143:Evolution, Molecular; D006801:Humans; D032085:Isochores / Q000235:genetics*; D008297:Male; D008647:Mesocricetus; D013090:Spermatocytes / Q000378:metabolism; D013573:Synaptonemal Complex / Q000235:genetics* / Q000378:metabolism
chemical_list: D032085:Isochores