title: Generation of Natural Killer Cell Memory during Viral Infection.
abstract: Immunological memory is classically regarded as an attribute of antigen-specific T and B lymphocytes of the adaptive immune system. Cells of the innate immune system, including natural killer (NK) cells, have been considered short-lived cytolytic cells that can rapidly respond against pathogens in an antigen-independent manner and then die off. However, NK cells have recently been described to possess traits of adaptive immunity, such as clonal expansion after viral antigen exposure to generate long-lived memory cells. In this review, we will discuss the current evidence for viral-induced NK cell memory in both mice and humans.
authors.affiliation: Immunology Program, Memorial Sloan Kettering Cancer Center, New York, N.Y., USA.
authors.forename: Timothy E
authors.initials: TE
authors.lastname: O'Sullivan
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Sun
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D014777:Virus Diseases / Q000276:immunology*
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