title: Possible salivary and serum biomarkers for oral lichen planus.
abstract: There are few reports concerning the potential for clinical application of oxidative stress (OS) and collagen degradation markers in oral lichen planus (OLP) patients. We investigated the possibility of using some disease-related biomarkers in saliva and serum of OLP patients. Our study included 30 patients with OLP and 30 controls. We evaluated serum and salivary OS biomarkers including 8-OHdG, MDA, uric acid, TAC and GPx. We also investigated collagen degradation markers such as CTX I and MMP-8. We found significantly increased salivary levels of MMP-8 and CTX I in the OLP group compared to controls and significant differences between the OLP and control groups in serum and saliva for 8-OHdG, MDA (significantly increased), uric acid, TAC and GPx (significantly reduced). Currently there are no criteria for evaluating which OLP patients have a greater risk of malignant transformation. In addition to clinical surveillance, the serum and salivary biomarkers that we evaluated may be useful biomarkers for monitoring OLP patients in the future.
authors.affiliation: a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.
authors.forename: A
authors.initials: A
authors.lastname: Totan
authors.affiliation: a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.
authors.forename: D
authors.initials: D
authors.lastname: Miricescu
authors.affiliation: b Oral Pathology Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.
authors.forename: I
authors.initials: I
authors.lastname: Parlatescu
authors.affiliation: a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.
authors.forename: M
authors.initials: M
authors.lastname: Mohora
authors.affiliation: a Biochemistry Department, Faculty of Dental Medicine , University of Medicine Carol Davila , Bucharest , Romania.
authors.forename: M
authors.initials: M
authors.lastname: Greabu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis; D017676:Lichen Planus, Oral / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D018384:Oxidative Stress; D012463:Saliva / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: oral lichen planus; oxidative stress; saliva