title: Mean platelet volume is elevated in patients with psoriasis vulgaris.
abstract: OBJECTIVE
  This retrospective study was done to investigate the mean platelet volume (MPV) level in patients with psoriasis vulgaris and its relationship with disease severity.
  
  
  METHODS
  We undertook a cross-sectional study on 176 patients and 101 healthy controls to examine the association between MPV and psoriasis. Various clinical and laboratory parameters were analyzed and compared.
  
  
  RESULTS
  Platelet distribution width and MPV were significantly higher in patients with psoriasis than controls. In addition, there was positive correlation between Psoriasis Area Severity Index (PASI) and MPV. When psoriasis patients were grouped into mild psoriasis (PASI<10) and moderate to severe psoriasis (PASI≥10), the MPV of the latter group was significantly elevated. Nevertheless, patients with higher MPV level (MPV≥10.4 fL) did not show higher PASI than lower MPV level (MPV<10.4 fL). MPV levels significantly decreased after improvements of psoriasis with various treatments. The variations of MPV and PASI also showed significant correlation.
  
  
  CONCLUSIONS
  We have shown that MPV is increased in psoriasis patients and correlates with disease severity. Therefore, MPV levels may be considered as a marker of disease severity of psoriasis.
authors.affiliation: Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Dae Suk
authors.initials: DS
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jungsoo
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Dermatology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
authors.forename: Soo Min
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. mglee@yuhs.ac.
authors.forename: Min-Geol
authors.initials: MG
authors.lastname: Lee
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D011565:Psoriasis / Q000097:blood* / Q000503:physiopathology*; D012189:Retrospective Studies; D012720:Severity of Illness Index
keywords: Psoriasis; mean platelet volume; platelet distribution width
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