title: Differences in clinical features of Crohn's disease and intestinal tuberculosis.
abstract: OBJECTIVE
  To investigate the clinical features of Crohn's disease (CD) and intestinal tuberculosis (ITB) with a scoring system that we have developed.
  
  
  METHODS
  A total of 25 CD and 40 ITB patients were prospectively enrolled from August 2011 to July 2012. Their characteristics and clinical features were recorded. Laboratory, endoscopic, histologic and radiographic features were determined. The features with a high specificity were selected to establish a scoring system. The features supporting CD scored +1, and those supporting ITB scored -1; each patient received a final total score. A receiver operating characteristic (ROC) curve was used to determine the best cut-off value for distinguishing CD from ITB.
  
  
  RESULTS
  Based on a high specificity of differentiating between CD and ITB, 12 features, including longitudinal ulcers, nodular hyperplasia, cobblestone-like mucosa, intestinal diseases, intestinal fistula, the target sign, the comb sign, night sweats, the purified protein derivative test, the interferon-γ release assay (T-SPOT.TB), ring ulcers and ulcer scars, were selected for the scoring system. The results showed that the average total score of the CD group was 3.12 ± 1.740, the average total score of the ITB group was -2.58 ± 0.984, the best cutoff value for the ROC curve was -0.5, and the diagnostic area under the curve was 0.997, which was statistically significant (P < 0.001). The patients whose total scores were higher than -0.5 were diagnosed with CD; otherwise, patients were diagnosed with ITB. Overall, the diagnostic accuracy rate and misdiagnosis rate of this scoring system were 97% and 3%, respectively.
  
  
  CONCLUSIONS
  Some clinical features are valuable for CD and ITB diagnosis. The described scoring system is key to differentiating between CD and ITB.
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Wang-Di
authors.initials: WD
authors.lastname: Liao
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yu
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tu
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Pan
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: You-Xiang
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Nong-Hua
authors.initials: NH
authors.lastname: Lv
authors.affiliation: Xin Huang, Wang-Di Liao, Xiao-Lin Pan, You-Xiang Chen, Nong-Hua Lv, Xuan Zhu, Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D003106:Colon / Q000000981:diagnostic imaging / Q000382:microbiology / Q000473:pathology; D003113:Colonoscopy; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D059425:Interferon-gamma Release Tests; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D011859:Radiography; D014374:Tuberculin Test; D014385:Tuberculosis, Gastrointestinal / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology; D055815:Young Adult
keywords: Clinical features; Crohn’s disease; Differential diagnosis; Intestinal tuberculosis; Scoring system
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