title: [Research progress of effects of strontium ranelate on osteoarthritis].
abstract: OBJECTIVE
  To review the research progress focused on the effects of strontium ranelate (SR) on osteoarthritis.
  
  
  METHODS
  The relevant literature about the effects and mechanism of SR intervening osteoarthritis in recent years was extensively reviewed and comprehensively analyzed.
  
  
  RESULTS
  SR not only could improve the microenvironment of bone metabolism in articular cartilage with osteoarthritis, promote activity of osteoblasts, and inhibit activity of osteoclasts, but also could adjust the expression of key proteases which affect cartilage formation, and therefore it has a potential protective effect on subchondral bone during the progression of osteoarthritis cartilage.
  
  
  CONCLUSIONS
  SR is expected to become a drug of osteoarthritis disease remission, but further studies are needed to clarify the mechanism of SR in osteoarthritis, and finally confirm the best application dosage of SR in osteoarthritis treatment.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Muwei
authors.initials: M
authors.lastname: Dai
authors.forename: Faming
authors.initials: F
authors.lastname: Tian
authors.forename: Liu
authors.initials: L
authors.lastname: Zhang
mesh_terms: D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001842:Bone and Bones; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D009942:Organometallic Compounds; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D013876:Thiophenes / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate