title: Role of PMK-1/p38 MAPK defense in Caenorhabditis elegans against Klebsiella pneumoniae infection during host-pathogen interaction.
abstract: The present study reports that Klebsiella pneumoniae (KP) killed the Caenorhabditis elegans as a consequence of an accumulation and proliferation of the pathogen inside the worms' intestine. The real-time PCR analysis of the genes responsible for vulval development (let-23) and egg laying (lin-29) in KP infected C. elegans confirmed the reproductive defects provoked by KP at the molecular level. In addition, the genetic analysis in N2 wild type, tol-1, sek-1 and pmk-1 mutants unveiled that KP attenuates the toll-dependent p38 mitogen-activated protein kinase (p38 MAPK) by chiefly inhibiting the production of antimicrobial factors such as nlp-29, lys-1 and C-type lectins. Conclusively, the surrendering of the host immune system appears to be attenuated by the toll-dependent p38 MAPK pathway regulation in C. elegans.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630 004, Tamil Nadu, India.
authors.forename: Arumugam
authors.initials: A
authors.lastname: Kamaladevi
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630 004, Tamil Nadu, India bsuryar@yahoo.com.
authors.forename: Krishnaswamy
authors.initials: K
authors.lastname: Balamurugan
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology*; D029742:Caenorhabditis elegans Proteins / Q000037:antagonists & inhibitors*; D054884:Host-Pathogen Interactions; D057131:Immune Evasion; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000276:immunology*; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*
chemical_list: D029742:Caenorhabditis elegans Proteins; D020928:Mitogen-Activated Protein Kinases; C463460:Pmk-1 protein, C elegans; D048051:p38 Mitogen-Activated Protein Kinases
keywords: Caenorhabditis elegans; Klebsiella pneumoniae; host immunity; p38 mitogen-activated protein kinase; toll-like receptor