title: Factors associated with asthma control in patients with aspirin-exacerbated respiratory disease.
abstract: BACKGROUND
  Effective control of asthma is the primary goal of its treatment. Despite an improved understanding of asthma pathogenesis and accessibility of novel therapies, the rate of uncontrolled asthma remains high.
  
  
  OBJECTIVE
  To find potential factors associated with asthma control in patients with aspirin-exacerbated respiratory disease (AERD).
  
  
  METHODS
  Clinical data were collected from a specifically structured questionnaire. Demographics, a history of upper airway symptoms, asthma course, exacerbations expressed as emergency department (ED) visits/hospitalizations, and asthma treatment were considered. Spirometry, skin prick tests, total IgE concentration, and blood eosinophil count were evaluated. Asthma control was assessed through the Asthma Control Test (ACT).
  
  
  RESULTS
  Out of 201 AERD patients, 41 (20.4%), 69 (34.3%), and 91 (45.3%) had controlled, partially controlled, and uncontrolled asthma, respectively. A multivariate ordered logistic regression analysis revealed that hospitalizations for asthma in the previous 12 months (OR 2.88; 95%CI, 1.11-7.46), ED visits for asthma throughout its duration (OR 1.05; 95%CI, 1.004-1.10), and total IgE concentration (OR 1.28; 95%CI, 1.02-1.60) were positively associated with poor asthma control, whereas FEV1 values (OR 0.98; 95%CI, 0.96-0.99) and medical care at a referential specialty clinic (OR 0.50; 95%CI, 0.27-0.95) were positively associated with good asthma control.
  
  
  CONCLUSIONS
  The prevalence of uncontrolled asthma in AERD patients is high and similar to that observed in different asthmatic populations. Owing both to the specificity and complexity of the disease, AERD patients should stay under regular care of well experienced referential medical centers to ensure that this asthma phenotype is dealt with effectively.
authors.affiliation: Department of Internal Medicine, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland. Electronic address: mmbochen@cyf-kr.edu.pl.
authors.forename: Grazyna
authors.initials: G
authors.lastname: Bochenek
authors.affiliation: Department of Epidemiology and Population Studies, Faculty of Health Sciences, Jagiellonian University Medical College, Grzegorzecka 20, 31-531 Krakow, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Szafraniec
authors.affiliation: Department of Internal Medicine, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kuschill-Dziurda
authors.affiliation: Department of Internal Medicine, Jagiellonian University Medical College, Skawinska 8, 31-066 Krakow, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Nizankowska-Mogilnicka
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects*; D055963:Asthma, Aspirin-Induced / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D015331:Cohort Studies; D004804:Eosinophils / Q000473:pathology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011044:Poland / Q000453:epidemiology; D015995:Prevalence
chemical_list: D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007073:Immunoglobulin E; D001241:Aspirin
keywords: Aspirin-exacerbated respiratory disease; Asthma control; Asthma control test; Asthma phenotype; Nonsteroidal anti-inflammatory drugs