title: Primary definitive radiotherapy with or without chemotherapy for squamous cell carcinoma of the temporal bone.
abstract: We aimed to evaluate the impact of concurrent chemoradiotherapy (CCRT) on the survival of patients with squamous cell carcinoma of the temporal bone. We retrospectively analyzed the data of 13 consecutive patients who were treated by definitive radiation therapy (RT) or CCRT as the initial treatment between 1999 and 2012. There were 5 patients with stage II disease, 5 with stage III, and 3 with stage IV, as classified according to the University of Pittsburgh system. Among these, 2, 4, and 3 patients, respectively, were treated by CCRT; whereas the remaining (3 patients with stage II and 1 with stage III) were treated by RT alone. Median follow-up duration was 39 months (12-106 months) in all cases, and 61.5 months (17-70 months) in censored cases. The 5-year overall survival (OS) rates were 51 % in all patients, and 40, 100, and 0 % in patients with stage II, stage III, and stage IV disease, respectively. In patients with stage II and III disease, the 5-year OS rates were 80 % in the CCRT group and 50 % in the RT-alone group. We found better prognosis in patients with stage II and III disease who were treated by CCRT. Only 2 patients treated by CCRT experienced adverse events more than grade 3, which were neutropenia and dermatitis. There was no late adverse event of bony necrosis. Our study results indicate that CCRT is safe and very effective as a first-line treatment for stage II and III squamous cell carcinoma of the temporal bone.
authors.affiliation: Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama, Japan. yousuke.kitani@gmail.com.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kitani
authors.affiliation: Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Kubota
authors.affiliation: Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Furukawa
authors.affiliation: Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: Kaname
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nakayama
authors.affiliation: Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nonaka
authors.affiliation: Department of Radiation Oncology, Kanagawa Cancer Center, 2-3-2 Nakao, Asahi-ku, Yokohama, Kanagawa, 241-8515, Japan.
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Mizoguchi
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D059248:Chemoradiotherapy / Q000009:adverse effects / Q000379:methods; D016371:Cranial Irradiation / Q000009:adverse effects / Q000379:methods; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009503:Neutropenia / Q000453:epidemiology / Q000209:etiology; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013701:Temporal Bone / Q000473:pathology*
keywords: CCRT; Carcinoma of the temporal bone; Concurrent chemoradiotherapy; Definitive radiotherapy
references.citation: Arch Otolaryngol Head Neck Surg. 2002 Jan;128(1):93-4
references.pmid: 11784271
references.citation: Lancet. 2000 Mar 18;355(9208):949-55
references.pmid: 10768432
references.citation: Arch Otolaryngol. 1975 Jan;101(1):23-5
references.pmid: 1119983
references.citation: Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1326-34
references.pmid: 17446002
references.citation: Auris Nasus Larynx. 2006 Sep;33(3):251-7
references.pmid: 16431060
references.citation: Ann Otol Rhinol Laryngol. 1990 Sep;99(9 Pt 1):714-21
references.pmid: 2396807
references.citation: Arch Otolaryngol. 1980 Nov;106(11):675-9
references.pmid: 6252880
references.citation: Am J Otol. 2000 Jul;21(4):582-8
references.pmid: 10912706
references.citation: Laryngoscope. 2010 Jun;120(6):1144-51
references.pmid: 20513031
references.citation: Head Neck. 1999 Aug;21(5):461-6
references.pmid: 10402528
references.citation: Head Neck. 2015 Jul;37(7):1073-80
references.pmid: 24692266
references.citation: J Laryngol Otol. 1989 Jul;103(7):653-6
references.pmid: 2760515
references.citation: Clin Oncol (R Coll Radiol). 2006 Jun;18(5):390-4
references.pmid: 16817330
references.citation: Otol Neurotol. 2011 Jun;32(4):665-9
references.pmid: 21436754
references.citation: J Laryngol Otol. 1991 May;105(5):346-8
references.pmid: 2040835
references.citation: Skull Base. 2011 May;21(3):153-8
references.pmid: 22451818
references.citation: Am J Otol. 1988 Sep;9(5):351-6
references.pmid: 3059809
references.citation: Arch Otolaryngol Head Neck Surg. 1994 Nov;120(11):1228-32
references.pmid: 7917206
references.citation: Am J Otol. 1998 Nov;19(6 Suppl):S1-15
references.pmid: 9827809
references.citation: Am J Otolaryngol. 2009 Jan-Feb;30(1):44-8
references.pmid: 19027512
references.citation: Otolaryngol Head Neck Surg. 1994 Mar;110(3):270-80
references.pmid: 8134137
references.citation: J Laryngol Otol. 1983 Apr;97(4):299-311
references.pmid: 6842060
references.citation: Laryngoscope. 1987 Feb;97(2):158-64
references.pmid: 3807618
references.citation: Laryngoscope. 1996 Oct;106(10):1234-7
references.pmid: 8849792