title: Brain/MINDS: brain-mapping project in Japan.
abstract: There is an emerging interest in brain-mapping projects in countries across the world, including the USA, Europe, Australia and China. In 2014, Japan started a brain-mapping project called Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS). Brain/MINDS aims to map the structure and function of neuronal circuits to ultimately understand the vast complexity of the human brain, and takes advantage of a unique non-human primate animal model, the common marmoset (Callithrix jacchus). In Brain/MINDS, the RIKEN Brain Science Institute acts as a central institute. The objectives of Brain/MINDS can be categorized into the following three major subject areas: (i) structure and functional mapping of a non-human primate brain (the marmoset brain); (ii) development of innovative neurotechnologies for brain mapping; and (iii) human brain mapping; and clinical research. Brain/MINDS researchers are highly motivated to identify the neuronal circuits responsible for the phenotype of neurological and psychiatric disorders, and to understand the development of these devastating disorders through the integration of these three subject areas.
authors.affiliation: Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan hidokano@brain.riken.jp hidokano@a2.keio.jp.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Okano
authors.affiliation: Laboratory for Cell Function Dynamics, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan matsushi@brain.riken.jp.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyawaki
authors.affiliation: Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan kasaik-tky@umin.net.
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007564:Japan; D009415:Nerve Net / Q000502:physiology; D012107:Research Design
keywords: brain mapping by integrated neurotechnologies for disease studies; neuropsychiatric and neurodegenerative diseases; optogenetics; super-resolution microscopy; tissue clearing; transgenic non-human primates
references.citation: Arch Gen Psychiatry. 2007 May;64(5):521-9
references.pmid: 17485604
references.citation: Cereb Cortex. 2016 Mar;26(3):1027-35
references.pmid: 25452567
references.citation: Microscopy (Oxf). 2015 Feb;64(1):57-67
references.pmid: 25527636
references.citation: ACS Chem Neurosci. 2012 Aug 15;3(8):585-92
references.pmid: 22896802
references.citation: Neuropsychol Rev. 2014 Mar;24(1):63-76
references.pmid: 24496903
references.citation: Nat Neurosci. 2014 Nov;17(11):1448-54
references.pmid: 25349911
references.citation: Nature. 2014 Oct 9;514(7521):151-2
references.pmid: 25297413
references.citation: Cell. 2014 Aug 14;158(4):945-58
references.pmid: 25088144
references.citation: Schizophr Res. 2013 Jul;147(2-3):355-61
references.pmid: 23688384
references.citation: Hum Brain Mapp. 2014 May;35(5):2073-98
references.pmid: 23894001
references.citation: J Neurosci. 2007 Oct 31;27(44):11991-8
references.pmid: 17978040
references.citation: Annu Rev Biomed Eng. 2014 Jul 11;16:103-29
references.pmid: 25014785
references.citation: Cell. 2014 Apr 24;157(3):726-39
references.pmid: 24746791
references.citation: Cold Spring Harb Protoc. 2011 Jun;2011(6):664-9
references.pmid: 21632773
references.citation: Semin Fetal Neonatal Med. 2012 Dec;17(6):336-40
references.pmid: 22871417
references.citation: Neuroradiology. 2010 Oct;52(10):865-73
references.pmid: 20033142
references.citation: Cell. 2014 Nov 6;159(4):896-910
references.pmid: 25417164
references.citation: Front Cell Neurosci. 2014 Aug 29;8:258
references.pmid: 25221475
references.citation: Angew Chem Int Ed Engl. 2014 Dec 15;53(51):13972-7
references.pmid: 25371081
references.citation: Curr Opin Neurobiol. 2010 Oct;20(5):667-75
references.pmid: 20833533
references.citation: Neurosci Res. 2015 Apr;93:136-43
references.pmid: 25315397
references.citation: Trends Biotechnol. 2011 Mar;29(3):144-52
references.pmid: 21251723
references.citation: Nat Protoc. 2012 Nov;7(11):1983-95
references.pmid: 23060243
references.citation: Neuroimage. 2011 Feb 14;54(4):2741-9
references.pmid: 21044887
references.citation: Psychiatry Clin Neurosci. 2010 Aug;64(4):394-402
references.pmid: 20546170
references.citation: Annu Rev Biochem. 1998;67:509-44
references.pmid: 9759496
references.citation: Front Psychiatry. 2013 Sep 23;4:115
references.pmid: 24069006
references.citation: N Engl J Med. 2013 Apr 4;368(14):1326-34
references.pmid: 23550670
references.citation: Nature. 2011 Mar 10;471(7337):183-8
references.pmid: 21390125
references.citation: J Neurosci. 2012 Apr 11;32(15):5039-53
references.pmid: 22496550
references.citation: Dev Growth Differ. 2014 Jan;56(1):53-62
references.pmid: 24387631
references.citation: Radiology. 2015 May;275(2):430-7
references.pmid: 25602507
references.citation: Exp Brain Res. 2011 Aug;213(1):63-71
references.pmid: 21713504
references.citation: Curr Opin Cell Biol. 2014 Oct;30:112-20
references.pmid: 25216352
references.citation: Nat Methods. 2011;8(10):871-8
references.pmid: 21909102
references.citation: Neurosci Res. 2015 Jan;90:65-71
references.pmid: 25433093
references.citation: Nature. 2011 Mar 10;471(7337):177-82
references.pmid: 21390124
references.citation: Nat Rev Neurosci. 2013 Sep;14(9):659-64
references.pmid: 23958663
references.citation: Nat Neurosci. 2013 Aug;16(8):1154-61
references.pmid: 23792946
references.citation: Neurosci Res. 2013 Feb;75(2):89-93
references.pmid: 23262062
references.citation: Methods Cell Biol. 2012;111:157-73
references.pmid: 22857928
references.citation: Neuroimage. 2014 Nov 15;102 Pt 1:207-19
references.pmid: 24361664
references.citation: Nature. 2007 Nov 1;450(7166):56-62
references.pmid: 17972876
references.citation: Cell. 2007 Mar 23;128(6):1205-17
references.pmid: 17382887
references.citation: Nature. 2009 May 28;459(7246):523-7
references.pmid: 19478777
references.citation: Neurosci Res. 2015 Apr;93:3-7
references.pmid: 25264372
references.citation: Development. 2013 Mar;140(6):1364-8
references.pmid: 23444362
references.citation: Nature. 2014 Apr 10;508(7495):207-14
references.pmid: 24695228
references.citation: Neuron. 2012 Mar 8;73(5):862-85
references.pmid: 22405199
references.citation: Biol Psychiatry. 2014 Oct 15;76(8):639-47
references.pmid: 24199662
references.citation: Radiology. 2008 Dec;249(3):855-64
references.pmid: 19011185
references.citation: Neuropsychol Rev. 2014 Mar;24(1):49-62
references.pmid: 24562737
references.citation: Nature. 2013 May 16;497(7449):332-7
references.pmid: 23575631
references.citation: Arch Gen Psychiatry. 2003 Aug;60(8):766-75
references.pmid: 12912760
references.citation: Hum Brain Mapp. 2011 Oct;32(10):1762-73
references.pmid: 20886579
references.citation: Neuron. 2005 Oct 20;48(2):189-99
references.pmid: 16242400
references.citation: Cell. 2013 Jun 20;153(7):1602-11
references.pmid: 23768684
references.citation: Neuron. 2006 Sep 7;51(5):527-39
references.pmid: 16950152
references.citation: Nature. 2013 Apr 18;496(7445):363-6
references.pmid: 23563268
references.citation: Nat Neurosci. 2011 Nov;14(11):1481-8
references.pmid: 21878933
references.citation: Cold Spring Harb Protoc. 2012 Feb;2012(2):213-7
references.pmid: 22301651
references.citation: Prog Brain Res. 2012;196:235-63
references.pmid: 22341329