title: Association of prior antiplatelet agents with mortality in sepsis patients: a nationwide population-based cohort study.
abstract: BACKGROUND
  Antiplatelet agents are widely used for cardiovascular disea ses, but their pleiotropic effects in sepsis are controversial.
  
  
  OBJECTIVE
  To investigate the association between antiplatelet agents and the survival benefit for sepsis patients.
  
  
  METHODS
  A nationwide population-based cohort and nested case-control study.
  
  
  METHODS
  Taiwan National Health Insurance database.
  
  
  METHODS
  All patients (age ≥18 years) who were hospitalized for sepsis between January 2000 and December 2010.
  
  
  METHODS
  Conditional logistic regression was used to adjust for confounding. Adjusted odd ratios (ORs) were used to compare the mortality rate due to sepsis in antiplatelet drug users and nonusers.
  
  
  RESULTS
  Of 683,421 included patients, 229,792 (33.6 %) patients died during hospitalization for sepsis, and the rest (64.4 %) survived to discharge. Use of antiplatelet agents before admission was associated with a lower risk of mortality in sepsis patients (aOR 0.82, 95 % confidence interval [CI] 0.81-0.83, P < 0.001). By using another case-control study design, the beneficial effect was more significant in current users (aOR 0.78, 95 % CI 0.76-0.79) than in recent users (aOR 0.88, 95 % CI 0.85-0.91), but was not significant in past users (aOR 1.00, 95 % CI 0.98-1.02).
  
  
  CONCLUSIONS
  Observational study.
  
  
  CONCLUSIONS
  Prior use of antiplatelet agents was associated with a survival benefit in sepsis patients.
authors.affiliation: Department of Internal Medicine, Taipei Veterans General Hospital, Suao Branch, Yilan, Taiwan.
authors.forename: Min-Juei
authors.initials: MJ
authors.lastname: Tsai
authors.forename: Shuo-Ming
authors.initials: SM
authors.lastname: Ou
authors.forename: Chia-Jen
authors.initials: CJ
authors.lastname: Shih
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Chao
authors.forename: Lan-Fu
authors.initials: LF
authors.lastname: Wang
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Shih
authors.forename: Szu-Yuan
authors.initials: SY
authors.lastname: Li
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Kuo
authors.forename: Yen-Tao
authors.initials: YT
authors.lastname: Hsu
authors.forename: Yung-Tai
authors.initials: YT
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality*; D013624:Taiwan / Q000453:epidemiology
chemical_list: D010975:Platelet Aggregation Inhibitors
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