title: Relationship of leptin with adiposity and inflammation and resistin with disease severity in psoriatic patients undergoing anti-TNF-alpha therapy.
abstract: BACKGROUND
  Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases.
  
  
  OBJECTIVE
  To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients who underwent anti-TNF-α therapy.
  
  
  METHODS
  Prospective study of consecutive non-diabetic patients with moderate-to-severe psoriasis who completed 6 months of therapy with anti-TNF-α- adalimumab. Patients with kidney disease, hypertension or body mass index ≥35 Kg/m(2) were excluded. Metabolic and clinical evaluation was performed at the onset of anti-TNF-α treatment and at month 6.
  
  
  RESULTS
  Twenty-nine patients were assessed. A correlation between adiposity and leptin was observed (waist circumference and leptin levels after 6 months of therapy: r = 0.43; P = 0.030). Leptin concentration also correlated with blood pressure before adalimumab onset (systolic: r = 0.48; P = 0.013 and diastolic blood pressure: r = 0.50; P = 0.010 ). A marginally significant negative correlation between insulin sensitivity (QUICKI) and leptin levels was also observed. CRP levels correlated with leptin prior to the onset of adalimumab (r = 0.45; P = 0.020) and with resistin both before (r = 0.45; P = 0.020) and after 6 months of therapy (r = 0.55; P = 0.004). A positive association between parameters of disease activity such as BSA (r = 0.60; P = 0.001) and PASI (r = 0.63; P = 0.001) prior to the onset of adalimumab therapy and resistin concentrations was also disclosed. No significant changes in leptin and resistin concentrations following the 6-month treatment with adalimumab were seen.
  
  
  CONCLUSIONS
  In patients with moderate-to-severe psoriasis leptin correlates with metabolic syndrome features and inflammation whereas resistin correlate with inflammation and disease severity.
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Pina
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Genre
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Lopez-Mejias
authors.affiliation: Dermatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Armesto
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: B
authors.initials: B
authors.lastname: Ubilla
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Mijares
authors.affiliation: Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain.
authors.forename: T
authors.initials: T
authors.lastname: Dierssen-Sotos
authors.affiliation: Dermatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez-Lopez
authors.affiliation: Pathology Division, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Santander, Spain.
authors.forename: M C
authors.initials: MC
authors.lastname: Gonzalez-Vela
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Blanco
authors.affiliation: Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Hernández
authors.affiliation: Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Llorca
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez-Gay
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use*; D050154:Adiposity; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D001830:Body Surface Area; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications; D011446:Prospective Studies; D011565:Psoriasis / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D055105:Waist Circumference
chemical_list: D000893:Anti-Inflammatory Agents; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D000068879:Adalimumab