title: Magnetic resonance imaging-measured bone marrow adipose tissue area is inversely related to cortical bone area in children and adolescents aged 5-18 years.
abstract: Previous studies have shown an inverse correlation between bone marrow adipose tissue and bone mineral density in cancellous bone; however, such relationships in cortical bone are less studied, especially in children. A total of 185 healthy children and adolescents (76 females and 109 males, aged 5-18 years) were included in this study. Right femoral bone marrow adipose tissue area (BMA), right femoral cortical bone area (CBA), subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle were accessed by whole-body magnetic resonance imaging. In regression analysis with CBA as the dependent variable and BMA as the independent variable, BMA negatively contributed to CBA after adjusting for weight and total body fat or subcutaneous adipose tissue, visceral adipose tissue, and skeletal muscle (β = -0.201 to -0.272, p < 0.001). These results suggest an inverse relationship between BMA and CBA in children and adolescents after adjustment of body weight or body composition. The data support the hypothesis that a competitive relationship exists between bone and marrow fat in cortical bone and is consistent with a similar finding in cancellous bone in previous studies. Future research is needed to clarify the role of marrow fat in childhood fractures that are related to cortical bone quality.
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA.
authors.forename: Kuang
authors.initials: K
authors.lastname: Zong
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA.
authors.forename: Zackary
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Metabolic Bone Disease Unit, Columbia University, New York, NY, USA.
authors.forename: Mishaela R
authors.initials: MR
authors.lastname: Rubin
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Metabolism-Body Composition, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
authors.forename: Steven B
authors.initials: SB
authors.lastname: Heymsfield
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA.
authors.forename: Dympna
authors.initials: D
authors.lastname: Gallagher
authors.affiliation: New York Obesity Research Center, Department of Medicine and Institute of Human Nutrition, Columbia University, New York, NY, USA. Electronic address: WS2003@Columbia.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D000293:Adolescent; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005269:Femur / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D006801:Humans; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D009929:Organ Size; D012044:Regression Analysis; D050151:Subcutaneous Fat / Q000033:anatomy & histology / Q000000981:diagnostic imaging
keywords: Adolescents; body composition; bone marrow adipose tissue; children; cortical bone area; dual-energy X-ray absorptiometry; magnetic resonance imaging
references.citation: Endocrinology. 2002 Oct;143(10):4065-73
references.pmid: 12239118
references.citation: J Clin Endocrinol Metab. 2011 Mar;96(3):782-6
references.pmid: 21177790
references.citation: Bone. 1996 Nov;19(5):421-8
references.pmid: 8922639
references.citation: Bonekey Rep. 2013 Apr 10;2:315
references.pmid: 23951544
references.citation: Hormones (Athens). 2005 Jan-Mar;4(1):18-27
references.pmid: 16574628
references.citation: J Clin Densitom. 2014 Jan-Mar;17(1):163-9
references.pmid: 23522982
references.citation: Osteoporos Int. 2012 Sep;23(9):2293-301
references.pmid: 22173789
references.citation: Int J Obes (Lond). 2007 Sep;31(9):1384-91
references.pmid: 17452992
references.citation: Pediatr Res. 2012 Oct;72(4):420-5
references.pmid: 22821057
references.citation: Osteoporos Int. 2012 Aug;23(8):2219-26
references.pmid: 22124576
references.citation: Eur J Appl Physiol. 2000 Jul;82(4):268-74
references.pmid: 10958368
references.citation: Spine (Phila Pa 1976). 2004 Dec 15;29(24):2844-50
references.pmid: 15599288
references.citation: J Clin Endocrinol Metab. 2013 May;98(5):E954-61
references.pmid: 23533226
references.citation: Obesity (Silver Spring). 2011 Jan;19(1):49-53
references.pmid: 20467419
references.citation: J Bone Miner Res. 2005 Oct;20(10):1858-66
references.pmid: 16160744
references.citation: Int J Pediatr Obes. 2011 Apr;6(2):149-56
references.pmid: 20528126
references.citation: J Clin Endocrinol Metab. 2013 Jun;98(6):2294-300
references.pmid: 23553860
references.citation: Osteoporos Int. 2007 May;18(5):641-7
references.pmid: 17139464
references.citation: Radiology. 2005 Sep;236(3):945-51
references.pmid: 16055699
references.citation: J Clin Invest. 2004 Mar;113(6):846-55
references.pmid: 15067317
references.citation: Eur J Clin Nutr. 2012 Sep;66(9):983-8
references.pmid: 22491495
references.citation: J Clin Endocrinol Metab. 2010 Jun;95(6):2977-82
references.pmid: 20392872
references.citation: AJR Am J Roentgenol. 1994 Jun;162(6):1399-406
references.pmid: 8192007
references.citation: Osteoporos Int. 2014 Aug;25(8):2035-45
references.pmid: 24809809
references.citation: J Bone Miner Res. 2004 Dec;19(12):1976-81
references.pmid: 15537440
references.citation: Nutr Metab (Lond). 2009 Apr 16;6:17
references.pmid: 19371437
references.citation: Mol Cell Endocrinol. 2010 Mar 25;316(2):147-53
references.pmid: 19723558
references.citation: Kidney Int. 2013 Mar;83(3):495-502
references.pmid: 23032560
references.citation: J Clin Endocrinol Metab. 2008 Jun;93(6):2281-6
references.pmid: 18381577
references.citation: J Clin Endocrinol Metab. 2013 May;98(5):1930-8
references.pmid: 23547048
references.citation: J Biomech. 2011 Feb 24;44(4):593-9
references.pmid: 21130997
references.citation: Biol Res. 2012;45(3):279-87
references.pmid: 23283437
references.citation: J Clin Endocrinol Metab. 2012 Apr;97(4):1337-46
references.pmid: 22319043