title: [Expression of RASAL2 in hepatocellular carcinoma and the clinical significance].
abstract: OBJECTIVE
  To detect the expression of RA SAL2 in patients with hepatocellular carcinoma (HCC), and to investigate the association of RASAL2 expression with pathological characteristics and prognosis.
  
  
  METHODS
  Immunohistochemical SP method was used to detect the expression of RA SAL2 in 164 samples of HCC tissue and the adjacent tissue. Th e association of RA SAL2 expression with clinical features and prognosis was analyzed.
  
  
  RESULTS
  The expression of RASAL2 in adjacent tissue was significantly increased compared to that in HCC tissue (P<0.001). The expression level of RASAL2 was associated with the degree of differentiation, tumor TNM stage and vascular invasion (P<0.001), but not associated with the level of AFP, tumor size, or the number of nodules (P>0.05). The 5 years recurrence-free survival (RFS) in patients with low expression of RASLA2 was significantly reduced compared with that in patients with high expression of RASLA2 (P<0.001). Cox analysis showed that low expression of RASLA2 was the independent factor for recurrence and death in HCC patients after surgery (P<0.001).
  
  
  CONCLUSIONS
  Low expression of RRASAL2 is significantly associated with the poor prognosis of HCC, which is an independent factor for HCC prognosis.
authors.affiliation: Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ganlu
authors.initials: G
authors.lastname: Deng
authors.forename: Junli
authors.initials: J
authors.lastname: Ma
authors.forename: Yanling
authors.initials: Y
authors.lastname: Qu
authors.forename: Shan
authors.initials: S
authors.lastname: Zeng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D020690:GTPase-Activating Proteins; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
chemical_list: D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; C576391:RASAL2 protein, human