title: History of fat grafting: from ram fat to stem cells.
abstract: Fat injection empirically started 100 years ago to correct contour deformities mainly on the face and breast. The German surgeon Eugene Hollaender (1867-1932) proposed a cocktail of human and ram fat, to avoid reabsorption. Nowadays, fat injection has evolved, and it ranks among the most popular procedures, for it provides the physician with a range of aesthetic and reconstructive clinical applications with regenerative effects on the surrounding tissues. New research from all over the world has demonstrated the role of adipose-derived stem cells, present in the adipose tissue, in the repair of damaged or missing tissues.
authors.affiliation: Department of Clinical Sciences and Community Health, Fondazione Ospedale Maggiore Policlinico IRCCS, Via F. Sforza 35, Milano 20122, Italy. Electronic address: riccardo.mazzola@fastwebnet.it.
authors.forename: Riccardo F
authors.initials: RF
authors.lastname: Mazzola
authors.affiliation: Department of Otolaryngology, Fondazione Ospedale Maggiore Policlinico IRCCS, Via F. Sforza 35, Milano 20122, Italy.
authors.forename: Isabella C
authors.initials: IC
authors.lastname: Mazzola
mesh_terms: D017667:Adipocytes / Q000637:transplantation; D000273:Adipose Tissue / Q000637:transplantation*; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D019651:Plastic Surgery Procedures / Q000266:history*; D044968:Regenerative Medicine / Q000266:history*; D033581:Stem Cell Transplantation / Q000266:history* / Q000379:methods; D013518:Surgery, Plastic / Q000266:history*
keywords: Adipose derived stem cells; Fat injection; History of fat grafting; History of surgery; Regenerative medicine