title: An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma.
abstract: Esophageal squamous cell cancer (ESCC) is an aggressive type of cancer with poor prognosis and leading to decreased quality of life. The identification of patients at increased risk of esophageal squamous cell cancer may improve current understanding of the role of micro (mi)RNA in tumorigenesis, since the miRNA pattern of these patients may be associated with tumorigenesis. In the present study, the miRNA and mRNA expression profiles of ESCC tissue samples and adjacent normal control tissue samples were obtained from two dependent GEO series. Bioinformatics analyses, including the use of the Gene Oncology and Kyoto Encyclopedia of Genes and Genomes databases, were used to identify genes and pathways, which were specifically associated with miRNA-associated ESCC oncology. A total of 17 miRNAs and 1,670 probes were differentially expressed in the two groups, and the differentially expressed miRNA and target interactions were analyzed. The mRNA of miRNA target genes were found to be involve 49 GO terms and 14 pathways. Of the genes differentially expressed between the two groups, miRNA-181a, miRNA-202, miRNA-155, FNDC3B, BNC2 and MBD2 were the most significantly altered and may be important in the regulatory network. In the present study, a novel pattern of differential miRNA-target expression was constructed, which with further investigation, may provide novel targets for diagnosing and understanding the mechanism of ESCC.
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated Tongji University, Shanghai 200433, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Linyi Tumor Hospital, Linyi, Shandong 276001, P.R. China.
authors.forename: Dianbo
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated Tongji University, Shanghai 200433, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated Tongji University, Shanghai 200433, P.R. China.
authors.forename: Gening
authors.initials: G
authors.lastname: Jiang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005353:Fibronectins / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D063990:Gene Ontology; D053263:Gene Regulatory Networks; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D058977:Molecular Sequence Annotation; D009367:Neoplasm Staging; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: C484527:BNC2 protein, human; D004268:DNA-Binding Proteins; C543006:FNDC3B protein, human; D005353:Fibronectins; C489325:MBD2 protein, human; C524942:MIRN155 microRNA, human; C569392:MIRN202 microRNA, human; C540193:MIrn181 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger
references.citation: Cancer Control. 2011 Jan;18(1):8-15
references.pmid: 21273975
references.citation: J Transl Med. 2011;9:30
references.pmid: 21426561
references.citation: Indian J Pathol Microbiol. 2014 Jan-Mar;57(1):13-8
references.pmid: 24739825
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8
references.pmid: 9843981
references.citation: Cell Death Differ. 2012 Mar;19(3):378-86
references.pmid: 21979467
references.citation: FEBS Lett. 2014 May 21;588(10):1913-20
references.pmid: 24704686
references.citation: Cell. 2005 Jan 14;120(1):15-20
references.pmid: 15652477
references.citation: Nature. 2008 Apr 17;452(7189):896-9
references.pmid: 18368051
references.citation: Mol Cell. 2007 Jul 6;27(1):91-105
references.pmid: 17612493
references.citation: Curr Opin Investig Drugs. 2006 Jun;7(6):560-4
references.pmid: 16784027
references.citation: Nat Struct Mol Biol. 2011 Oct;18(10):1139-46
references.pmid: 21909094
references.citation: Nature. 2005 Jun 9;435(7043):834-8
references.pmid: 15944708
references.citation: Gut. 2014 Nov;63(11):1700-10
references.pmid: 24522499
references.citation: Nat Med. 2005 Jul;11(7):712-4
references.pmid: 16015356
references.citation: J Radiat Res. 2013 May;54(3):401-8
references.pmid: 23188185
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):243-50
references.pmid: 15668501
references.citation: BMC Bioinformatics. 2006;7:30
references.pmid: 16423281
references.citation: Cancer Treat Rev. 2009 May;35(3):201-9
references.pmid: 19081199
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80
references.pmid: 14681412
references.citation: Genome Res. 2009 Jan;19(1):92-105
references.pmid: 18955434
references.citation: Exp Ther Med. 2012 Jul;4(1):33-42
references.pmid: 23060919
references.citation: Int J Clin Exp Pathol. 2014;7(2):602-10
references.pmid: 24551280
references.citation: Biomarkers. 2014 Feb;19(1):43-8
references.pmid: 24320161
references.citation: Genome Biol. 2003;4(5):P3
references.pmid: 12734009
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: Mol Cells. 2014 Dec 31;37(12):873-80
references.pmid: 25518924
references.citation: Pathol Oncol Res. 2014 Apr;20(2):381-9
references.pmid: 24531888
references.citation: J Gen Virol. 2005 Mar;86(Pt 3):751-5
references.pmid: 15722536
references.citation: Nature. 2005 Dec 1;438(7068):685-9
references.pmid: 16258535
references.citation: Genome Res. 2007 Oct;17(10):1537-45
references.pmid: 17785539
references.citation: Int J Cancer. 2011 Aug 1;129(3):565-73
references.pmid: 20878956
references.citation: BMC Genomics. 2006;7:252
references.pmid: 17029630
references.citation: Biochem Soc Trans. 2005 Dec;33(Pt 6):1537-40
references.pmid: 16246164
references.citation: Int J Cancer. 2009 Nov 15;125(10):2349-59
references.pmid: 19670330
references.citation: Clin Cancer Res. 2008 Jul 15;14(14):4631-9
references.pmid: 18628478
references.citation: Brief Bioinform. 2013 Mar;14(2):144-61
references.pmid: 22908213
references.citation: Clin Cancer Res. 2009 Oct 1;15(19):6192-200
references.pmid: 19789312
references.citation: Br J Cancer. 2011 Feb 15;104(4):545-53
references.pmid: 21119666
references.citation: Immunology. 2008 Oct;125(2):154-60
references.pmid: 18798919
references.citation: CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29
references.pmid: 24399786
references.citation: Zhonghua Zhong Liu Za Zhi. 2013 Aug;35(8):590-4
references.pmid: 24314216
references.citation: Cell Cycle. 2012 May 1;11(9):1773-81
references.pmid: 22510613
references.citation: Nucleic Acids Res. 2011 Jan;39(Database issue):D152-7
references.pmid: 21037258
references.citation: J Comput Biol. 2009 Feb;16(2):265-78
references.pmid: 19183004
references.citation: Gastroenterology. 2013 Oct;145(4):853-64.e9
references.pmid: 23770133