title: Basal cell adenoma-clinicopathological, immunohistochemical analysis and surgical considerations of a rare salivary gland tumor with review of literature.
abstract: BACKGROUND
  Basal cell adenoma (BCA) of the salivary glands is a rare benign salivary gland tumour. Differentiation of BCA from varied entities involving maxillofacial area is mandatory.
  
  
  OBJECTIVE
  To analyze the clinicopathological, histopathologic features, immunohistochemcal analysis and surgical considerations of this rare entity.
  
  
  METHODS
  This study included 12 cases of BCA from archives of department reported over the period of 13 years. All the pertaining clinicopathologic features such as incidence, age, sex and site of lesions were assessed. Tissue sections were stained by using panel of immunohistochemical markers, i.e. Pan CK, CK 5/6 and S100, Calponin, p63, CD 117 and smooth muscle actin.
  
  
  RESULTS
  BCA was observed in 26-52 years age group (mean age, 38.75 years) with female propensity of 7:5 male to female ratio. It is seen more commonly in parotid gland, followed by upper lip, buccal mucosa and palate. Solid type is the most common histopathologic type followed by tubular, membranous and trabecular. Only one case of membranous type of BCA showed recurrence. Pan CK, CK 5/6 showed strong immunoreactivity, calponin showed moderate staining, p63 and Ki-67 mild staining, whereas CD 117 and SMA showed negative immunostaining.
  
  
  CONCLUSIONS
  Vigilant comprehensive analysis of all the pertaining clinicopathologic and histopathologic features and immunohistochemical analysis are required for differentiating from other lesions with basaloid differentiation having varying prognosis.
authors.affiliation: Department of Oral Surgery, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India.
authors.forename: A D
authors.initials: AD
authors.lastname: Bhagat Singh
authors.affiliation: Department of Prosthodontics, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India.
authors.forename: Swapan
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Department of Conservative Dentistry, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India.
authors.forename: Amal Kanti
authors.initials: AK
authors.lastname: Ghosh
authors.affiliation: Department of Oral and Maxillofacial Surgery, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Gandi
authors.affiliation: Department of Oral Pathology, RKDF Dental College and Research Center, Bhopal, Madhya Pradesh, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Choudaha
authors.affiliation: Department of Oral Pathology, RKDF Dental College and Research Center, Bhopal, Madhya Pradesh, India.
authors.forename: Ipsita
authors.initials: I
authors.lastname: Sharma
authors.affiliation: Department of Orthodontics, Mithala Minority Dental College and Hospital, Mansukh Nagar, Darbhanga, Bihar, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Pal
keywords: Basal cell adenoma; basal cell adenocarcinoma; monomorphic adenoma
references.citation: Rev Eur Odontoestomatol. 1991 Sep-Oct;3(5):333-6
references.pmid: 1667078
references.citation: Oral Surg Oral Med Oral Pathol. 1980 Nov;50(5):433-40
references.pmid: 6935599
references.citation: J Oral Maxillofac Pathol. 2009 Jul;13(2):101-4
references.pmid: 21887012
references.citation: Acta Otorrinolaringol Esp. 1997 Mar;48(2):169-72
references.pmid: 9198471
references.citation: Acta Histochem Cytochem. 2012 Oct 31;45(5):269-82
references.pmid: 23209336
references.citation: Acta Otolaryngol. 1998 Jul;118(4):588-93
references.pmid: 9726688
references.citation: Oral Surg Oral Med Oral Pathol. 1982 Apr;53(4):375-86
references.pmid: 6281711
references.citation: Cancer. 1992 Jul 15;70(2):379-85
references.pmid: 1617588
references.citation: Laryngoscope. 1974 Oct;84(10):1756-66
references.pmid: 4371182
references.citation: Laryngoscope. 1997 Sep;107(9):1276-80
references.pmid: 9292617
references.citation: J Oral Maxillofac Surg. 2010 Jan;68(1):179-82
references.pmid: 20006174
references.citation: Am J Clin Oncol. 2008 Feb;31(1):95-9
references.pmid: 18376235
references.citation: J Nihon Univ Sch Dent. 1997 Sep;39(3):128-32
references.pmid: 9354027
references.citation: Am J Surg Pathol. 1992 Oct;16(10):939-46
references.pmid: 1384369
references.citation: Cancer. 1998 Feb 1;82(3):439-47
references.pmid: 9452259