title: [C-KIT in gastrointestinal stromal tumors and associated malignancies: A Study in a population with genetic isolation].
abstract: BACKGROUND
  Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Numerous studies have reported the association between GIST and other neoplasms.
  
  
  OBJECTIVE
  The aim of this study was to investigate the possible association between GIST and other tumors in a genetically isolated population.
  
  
  METHODS
  A retrospective study was conducted of patients with GIST between 2002 and 2009 at our center. Epidemiological, pathological and family data in patients with GIST alone (group A) were compared with those in patients with GIST associated with other neoplasms (group B). A possible common genetic mechanism was investigated between GIST and associated malignancies by testing the detection of the immunohistochemical marker, CD117, in all tumors.
  
  
  RESULTS
  Twenty-two patients with GIST were identified, 10 in group A (45%) and 12 in group B (55%). In group B, the associated tumor was malignant in 6 patients (50%) and benign in another 6 (50%). Of the 22 patients with GIST, 8 (36%) had a family history of malignancies. Of these 8 patients, 7 (87.5%) were in group B (p=0.03) and 3 (37.5%) showed the same pathological type of neoplasm as their relatives. All GIST were positive for CD117 whereas associated malignancies were negative for this marker.
  
  
  CONCLUSIONS
  We did not find immunohistochemical positivity for CD117 in malignancies associated with GIST. Given the special characteristics of the study population, the association between GIST and associated malignancies may be incidental.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: Diana
authors.initials: D
authors.lastname: Rodríguez-González
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España. Electronic address: lucianodelgado1@gmail.com.
authors.forename: Luciano
authors.initials: L
authors.lastname: Delgado-Plasencia
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández-León
authors.affiliation: Servicio de Radiología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: Esther
authors.initials: E
authors.lastname: Torres-Monzón
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: María Elisa
authors.initials: ME
authors.lastname: Castro-Peraza
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario de Canarias, La Cuesta, Santa Cruz de Tenerife, España.
authors.forename: Josefina
authors.initials: J
authors.lastname: Cruz-Jurado
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bravo-Gutiérrez
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital Universitario de Canarias, Santa Cruz de Tenerife, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Medina-Arana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D005192:Family Health; D005260:Female; D018703:Founder Effect; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000208:ethnology / Q000235:genetics*; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000208:ethnology / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000208:ethnology / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis / Q000235:genetics*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D019009:Proto-Oncogene Proteins c-kit
keywords: Aislamiento genético; Associated neoplasm; CD117; Gastrointestinal stromal tumor; Genetic isolation; Neoplasia asociada; Tumores estromales gastrointestinales