title: [Aspirin hypersensitivity: characteristics and diagnostic approach].
abstract: BACKGROUND
  In routine medical practice, the diagnosis of aspirin hypersensitivity (AH) remains difficult. No clinical feature or biomarker is available to reliably confirm this diagnosis and oral provocation tests (OPT) are rarely performed.
  
  
  OBJECTIVE
  To compare asthmatics with and without AH.
  
  
  METHODS
  The clinical characteristics of 21 asthmatics with and 24 without AH respectively were determined. AH was defined by a positive OPT. A full blood count was done before and 24 hours after the OPT.
  
  
  RESULTS
  The medical history was associated with a weak sensitivity (52%) and a good specificity (96%) for assessing the diagnosis of AH. There was a higher prevalence of AH in women, and a higher frequency of allergic rhinitis in AH, but no characteristic was useful to facilitate the diagnosis of AH in asthmatic patients. Our results demonstrate higher values of platelets in AH patients. Following OPT, in AH patients only, a decrease in blood eosinophils and an increase in neutrophils was observed.
  
  
  CONCLUSIONS
  These results confirm that the diagnosis of AH is challenging, with the history having only weak sensitivity. The observation that fluctuations in eosinophils and neutrophils occur following OPT in AH patients only warrants further investigations and suggests a rapid pro-inflammatory role for aspirin.
authors.affiliation: Service de pneumologie, centre hospitalier Lyon Sud, HCL, 69317 Lyon, France.
authors.forename: H
authors.initials: H
authors.lastname: Baudrand
authors.affiliation: Service d'ORL, centre hospitalier Lyon Sud, HCL, 69003 Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Zaouche
authors.affiliation: Service de pneumologie, hôpital Louis-Pradel, HCL, 69500 Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Dubost
authors.affiliation: Service de pneumologie, centre hospitalier Lyon Sud, HCL, 69317 Lyon, France.
authors.forename: A
authors.initials: A
authors.lastname: Carsin
authors.affiliation: Service de pneumologie, 69004 Caluire, France.
authors.forename: G
authors.initials: G
authors.lastname: Chatte
authors.affiliation: Service de pneumologie, centre hospitalier Lyon Sud, HCL, 69317 Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Freymond
authors.affiliation: Service de pneumologie, 69006 Lyon, France.
authors.forename: D
authors.initials: D
authors.lastname: Piperno
authors.affiliation: Service d'ORL, centre hospitalier Lyon Sud, HCL, 69003 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Dubreuil
authors.affiliation: Service d'ORL, hôpital E.-Herriot, HCL, 69003 Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Froehlich
authors.affiliation: Service de pneumologie, centre hospitalier Lyon Sud, HCL, 69317 Lyon, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Pacheco
authors.affiliation: Service de pneumologie, hôpital de la Croix-Rousse, HCL, 103, Grande-Rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France. Electronic address: gilles.devouassoux@chu-lyon.fr.
authors.forename: G
authors.initials: G
authors.lastname: Devouassoux
mesh_terms: D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects* / Q000276:immunology; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D001772:Blood Cell Count; D001792:Blood Platelets / Q000187:drug effects; D015897:Comorbidity; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology; D004804:Eosinophils / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000453:epidemiology; D009504:Neutrophils / Q000187:drug effects; D011446:Prospective Studies; D012130:Respiratory Hypersensitivity / Q000139:chemically induced; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000453:epidemiology; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D055815:Young Adult
chemical_list: D018927:Anti-Asthmatic Agents; D001241:Aspirin
keywords: Aspirin; Aspirine; Asthma; Asthme; Drug hypersensitivity; Inflammation; Intolérance médicamenteuse; Nasal polyposis; Polypose naso-sinusienne