title: Visceral pain and gastrointestinal microbiome.
abstract: A complex set of interactions between the microbiome, gut and brain modulate responses to visceral pain. These interactions occur at the level of the gastrointestinal mucosa, and via local neural, endocrine or immune activity; as well as by the pro-duction of factors transported through the circulatory system, like bacterial metabolites or hormones. Various psychological, in-fectious and other stressors can disrupt this harmonious relationship and alter both the microbiome and visceral pain responses. There are critical sensitive periods that can impact visceral pain responses in adulthood. In this review we provide a brief background of the intestinal microbiome and emerging concepts of the bidirectional interactions between the micro-biome, gut and brain. We also discuss recent work in animal models, and human clinical trials using prebiotics and probiotics that alter the microbiome with resultant alterations in visceral pain responses.
authors.affiliation: Mead Johnson Nutrition, Evansville, IN, USA.
authors.forename: Maciej
authors.identifier: http://orcid.org/0000-0002-6004-2195
authors.initials: M
authors.lastname: Chichlowski
authors.affiliation: Mead Johnson Nutrition, Evansville, IN, USA.|Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, CA, USA.
authors.forename: Colin
authors.identifier: http://orcid.org/0000-0002-2842-1224
authors.initials: C
authors.lastname: Rudolph
keywords: Microbiome; Prebiotics; Probiotics; Visceral pain
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