title: Serum nesfatin-1 and leptin levels in non-obese girls with premature thelarche.
abstract: OBJECTIVE
  We aimed to investigate serum nesfatin-1 level in girls with premature thelarche (PT) and its relationship with anthropometric parameters and leptin, which are involved in the initiation of pubertal process.
  
  
  METHODS
  Non-obese girls who presented with the complaint of early (2-8 years) and isolated breast development were included in the study. The control group consisted of age-matched healthy prepubertal girls. Auxological measurements were performed in all subjects. Gonadotropin-releasing hormone (GnRH) stimulation test and bone age assessment were conducted in subjects with early breast development. Girls with a bone age/chronologic age ratio <1.2 and a peak luteinizing hormone (LH) response to GnRH stimulation <5 mIU/L were included in the PT group.
  
  
  RESULTS
  The study included 22 non-obese girls with PT and 24 healthy prepubertal controls. Body mass index (BMI), BMI-standard deviation score (SDS) and height SDS were similar between the groups (p > 0.05). Serum leptin and nesfatin-1 levels were found significantly higher in the PT group compared to controls (p < 0.05). No correlation was detected between nesfatin-1 and basal LH, basal follicle stimulating hormone (FSH), stimulated peak LH, peak FSH, leptin levels and anthropometric parameters in the PT group (p > 0.05).
  
  
  CONCLUSIONS
  Results of the present study showed that serum nesfatin-1 and leptin levels are significantly higher in girls with PT than in prepubertal controls. This finding suggests that similar to leptin, nesfatin-1 may also have a central or peripheral role in the initiation of pubertal process and may be related to PT pathogenesis.
authors.affiliation: Pediatric Endocrinology Unit, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Çatlı
authors.forename: A
authors.initials: A
authors.lastname: Anık
authors.forename: T
authors.initials: T
authors.lastname: Küme
authors.forename: Ö G
authors.initials: ÖG
authors.lastname: Çalan
authors.forename: B N
authors.initials: BN
authors.lastname: Dündar
authors.forename: E
authors.initials: E
authors.lastname: Böber
authors.forename: A
authors.initials: A
authors.lastname: Abacı
mesh_terms: D015415:Biomarkers / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D009765:Obesity; D011629:Puberty, Precocious / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D020738:Leptin; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins
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