title: Decisional impairments in cocaine addiction, reward bias, and cortical oscillation "unbalance".
abstract: A vast amount of research has suggested that subjects with substance use disorder (SUD) might have difficulty making advantageous decisions that opt in favor of a longer-term, larger reward than an immediate, smaller reward. The current research explored the impact of reward bias and cortical frontal asymmetry (left lateralization effect) in SUD in response to a decisional task (Iowa Gambling Task). Fifty SUD participants and 40 controls (CG) were tested using the Iowa Gambling Task. Electrophysiology (electroencephalography) recording was performed during task execution. We measured left and right dorsolateral prefrontal cortex power activity. Behavioral responses (gain/loss options); frequency band modulation (asymmetry index) for delta, theta, alpha, and beta band; and cortical source localization (standardized low-resolution brain electromagnetic tomography) were considered. The SUD group opted in favor of the immediate reward option (loss) more frequently than the long-term option (gain) when compared to the CG. Secondly, SUD showed increased left-hemisphere activation in response to losing (with immediate reward) choices in comparison with the CG. The left hemispheric unbalance effect and the "reward bias" were adduced to explain the decisional impairment in SUD.
authors.affiliation: Research Unit in Affective and Social Neuroscience, Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Balconi
authors.affiliation: Research Unit in Affective and Social Neuroscience, Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Finocchiaro
keywords: Iowa Gambling Task; cortical brain oscillations; drug addiction; left lateralization effect; reward mechanism
references.citation: Science. 2006 Nov 3;314(5800):829-32
references.pmid: 17023614
references.citation: Psychophysiology. 1986 Nov;23(6):695-703
references.pmid: 3823345
references.citation: J Neuropsychiatry Clin Neurosci. 2007 Summer;19(3):298-303
references.pmid: 17827415
references.citation: Behav Pharmacol. 2006 Dec;17(8):651-67
references.pmid: 17110792
references.citation: Brain Cogn. 2008 Apr;66(3):243-52
references.pmid: 17942206
references.citation: Biol Psychol. 2004 Oct;67(1-2):219-33
references.pmid: 15130532
references.citation: Behav Neurosci. 2003 Feb;117(1):11-20
references.pmid: 12619903
references.citation: Laterality. 2010 May;15(3):361-84
references.pmid: 19536685
references.citation: Neuropsychologia. 2002;40(10):1675-89
references.pmid: 11992656
references.citation: Int J Psychophysiol. 1994 Oct;18(1):49-65
references.pmid: 7876038
references.citation: Clin EEG Neurosci. 2009 Jan;40(1):1-4
references.pmid: 19278126
references.citation: Drug Alcohol Depend. 1998 Apr 1;50(2):137-45
references.pmid: 9649965
references.citation: Addiction. 2001 Jan;96(1):73-86
references.pmid: 11177521
references.citation: Neuroimage. 2003 Jul;19(3):1085-94
references.pmid: 12880834
references.citation: Clin EEG Neurosci. 2015 Jul;46(3):197-207
references.pmid: 24677014
references.citation: Neurosci Biobehav Rev. 2004 May;28(3):343-51
references.pmid: 15225976
references.citation: Eur J Neurosci. 2010 Feb;31(3):593-7
references.pmid: 20105234
references.citation: Cereb Cortex. 2006 Jul;16(7):1040-55
references.pmid: 16207931
references.citation: Neuropsychologia. 2004;42(7):939-43
references.pmid: 14998708
references.citation: Hum Brain Mapp. 2006 Jul;27(7):572-87
references.pmid: 16372256
references.citation: Psychophysiology. 1993 Jan;30(1):82-9
references.pmid: 8416065
references.citation: Cognition. 1994 Apr-Jun;50(1-3):7-15
references.pmid: 8039375
references.citation: Open Neuroimag J. 2010;4:114-20
references.pmid: 21673979
references.citation: Addict Behav. 2014 Jun;39(6):1026-32
references.pmid: 24629323
references.citation: Nat Neurosci. 2005 Nov;8(11):1458-63
references.pmid: 16251988
references.citation: Psychiatry Res. 2008 Mar 15;158(2):172-80
references.pmid: 18237786
references.citation: Biol Psychiatry. 2007 Mar 1;61(5):720-4
references.pmid: 16950228
references.citation: Alcohol Clin Exp Res. 2005 Dec;29(12):2158-69
references.pmid: 16385186
references.citation: Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20895-9
references.pmid: 19948957
references.citation: Brain Res Rev. 2011 Jan 1;65(2):124-49
references.pmid: 20837060
references.citation: Electroencephalogr Clin Neurophysiol Suppl. 1999;52:3-6
references.pmid: 10590970
references.citation: Phys Med Biol. 2007 Apr 7;52(7):1783-800
references.pmid: 17374911
references.citation: J Neurophysiol. 2009 Mar;101(3):1679-89
references.pmid: 19109453
references.citation: Trends Mol Med. 2006 Dec;12(12):559-66
references.pmid: 17070107
references.citation: Neuron. 2004 Nov 18;44(4):729-40
references.pmid: 15541319
references.citation: Biol Psychol. 2004 Oct;67(1-2):51-76
references.pmid: 15130525
references.citation: Psychol Sci. 2009 Jan;20(1):33-8
references.pmid: 19152538
references.citation: Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12
references.pmid: 12575463
references.citation: Electroencephalogr Clin Neurophysiol. 1992 Oct;83(4):236-47
references.pmid: 1382945
references.citation: Neuropharmacology. 2009;56 Suppl 1:48-62
references.pmid: 18722390
references.citation: Harv Rev Psychiatry. 2004 Nov-Dec;12(6):305-20
references.pmid: 15764467
references.citation: J Neurosci. 1999 Jul 1;19(13):5473-81
references.pmid: 10377356
references.citation: Neuroimage Clin. 2013 Mar 05;2:385-93
references.pmid: 24179792
references.citation: Int J Psychophysiol. 2009 Nov;74(2):158-65
references.pmid: 19709636