title: Highlights on mechanisms of drugs targeting MDSCs: providing a novel perspective on cancer treatment.
abstract: The hallmark of tumor microenvironment is that it makes up of numerous immunomodulatory cells and factors which exert essential roles in immunoprotection and immunosuppression in addition to tumor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells reported to promote immunosuppression and angiogenesis and facilitate tumor metastasis and invasion. The wide scope of MDSCs functional activities make these cells promising targets for effective cancer treatments. In this review, we briefly discuss the origin, subpopulation, and functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. We focus on the underlying molecular mechanisms of these drugs targeting MDSCs, mainly from the standpoint of molecules related to drug targets.
authors.affiliation: Department of immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.forename: Qian
authors.initials: Q
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Shui
authors.initials: S
authors.lastname: Cao
authors.forename: Xiubao
authors.initials: X
authors.lastname: Ren
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D022423:Myeloid Cells / Q000187:drug effects*; D009369:Neoplasms / Q000188:drug therapy*; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents
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