title: [AntI-inflammatory, antipyretic and antimicrobial activity of flavonoid-containing extract of Gratiola officinalis L].
abstract: The extract of Gratiola officinalis L. has been obtained by an original method ensuring the maximum yield of flavonoids. The extract simultaneously exhibits high anti-inflammatory activity, selective antimicrobial properties (with respect to Staphylococcus aureus and Pseudomonas aeruginosa, but not to conditionally pathogenic E. coli) and antipyretic effect (observed for the first time in Gratiola officinalis L. preparations). Advantages of the proposed preparation are low toxicity, availability of the raw material, and broad spectrum of therapeutic effects.
authors.forename: N V
authors.initials: NV
authors.lastname: Polukonova
authors.forename: N A
authors.initials: NA
authors.lastname: Navolokin
authors.forename: S V
authors.initials: SV
authors.lastname: Raĭkova
authors.forename: G N
authors.initials: GN
authors.lastname: Masliakova
authors.forename: A B
authors.initials: AB
authors.lastname: Bucharskaia
authors.forename: N A
authors.initials: NA
authors.lastname: Durnova
authors.forename: G M
authors.initials: GM
authors.lastname: Shub
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D058633:Antipyretics / Q000302:isolation & purification / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D005334:Fever / Q000188:drug therapy* / Q000503:physiopathology; D005419:Flavonoids / Q000494:pharmacology; D006614:Hindlimb; D020128:Inhibitory Concentration 50; D019686:Lamiaceae / Q000737:chemistry*; D007928:Lethal Dose 50; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D005419:Flavonoids; D010936:Plant Extracts; D004008:Diclofenac