title: Strigolactam: New potent strigolactone analogues for the germination of Orobanche cumana.
abstract: Very recently, strigolactones have been conclusively identified as phytohormones. The progresses achieved in this field are culminating in the identification of the molecular receptors involved in the signal transduction mechanism. The exact mechanism of the mode of action of strigolactones still remains to be fully elucidated and we were interested to gain some insight into the mechanism of action of strigolactones by selectively modifying the reactivity of the lactone C-ring. Therefore, we report here the synthesis of strigolactams 1 and 16 and their surprisingly good activity on the germination of Orobanche cumana parasitic weed seeds.
authors.affiliation: Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Lachia
authors.affiliation: Syngenta Crop Protection AG, Crop Protection Research, Research Biology, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.
authors.forename: Hanno Christian
authors.initials: HC
authors.lastname: Wolf
authors.affiliation: Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.
authors.forename: Pierre Joseph Marcel
authors.initials: PJ
authors.lastname: Jung
authors.affiliation: Syngenta Crop Protection AG, Crop Protection Research, Research Biology, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Screpanti
authors.affiliation: Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland. Electronic address: alain.de_mesmaeker@syngenta.com.
authors.forename: Alain
authors.initials: A
authors.lastname: De Mesmaeker
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018525:Germination / Q000187:drug effects; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D031672:Orobanche / Q000737:chemistry / Q000187:drug effects*; D012639:Seeds / Q000187:drug effects*
chemical_list: C000591191:GR24 strigolactone; D006575:Heterocyclic Compounds, 3-Ring; D007783:Lactones; D015107:4-Butyrolactone
keywords: Cyclobutanones; Ketene-iminium salts; Orobanche cumana; Seed germination induction; Strigolactones