title: Methylphenidate Efficacy: Immediate versus Extended Release at Short Term in Mexican Children with ADHD Assessed by Conners Scale and EEG.
abstract: Attention deficit hyperactivity disorder (ADHD) affects 5-6% of school aged children worldwide. Pharmacological therapy is considered the first-line treatment and methylphenidate (MPH) is considered the first-choice medication. There are two formulations: immediate release (IR) MPH and long-acting (or extended release) formulation (MPH-ER). In this work, we measure the efficacy of treatment for both presentations in one month with Conners' scales and electroencephalography (EEG). Results. for IR group, in parents and teachers Conners test, all items showed significant differences, towards improvement, except for teachers in perfectionism and emotional instability. For ER group in parent's Conners test, the items in which there were no significant differences are psychosomatic and emotional instability. For teachers, there were no significant differences in: hyperactivity and perfectionism. Comparing the Conners questionnaires (parents versus teachers) we find significant differences before and after treatment in hyperactivity, perfectionism, psychosomatics, DSM-IV hyperactive-impulsive, and DSM-IV total. In the EEG the Wilcoxon test showed a significant difference (P < 0.0001). As we can see, both presentations are suitable for managing the ADHD and have the same effect on the symptomatology and in the EEG.
authors.affiliation: Laboratorio de Neuroprotección, Servicio de Neurorrehabilitación, Instituto Nacional de Rehabilitación, 14389 México, DF, Mexico ; Centro de Atención Médica y Educación Especial, 14370 México, DF, Mexico.
authors.forename: Alfredo
authors.identifier: 0000-0003-0950-2368
authors.initials: A
authors.lastname: Durand-Rivera
authors.affiliation: Laboratorio de Neuroprotección, Servicio de Neurorrehabilitación, Instituto Nacional de Rehabilitación, 14389 México, DF, Mexico.
authors.forename: Efren
authors.initials: E
authors.lastname: Alatorre-Miguel
authors.affiliation: Laboratorio de Neurofisiología Cognitiva, Instituto Nacional de Rehabilitación, 14389 México, DF, Mexico.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Zambrano-Sánchez
authors.affiliation: Laboratorio de Neuroprotección, Servicio de Neurorrehabilitación, Instituto Nacional de Rehabilitación, 14389 México, DF, Mexico.
authors.forename: Celia
authors.initials: C
authors.lastname: Reyes-Legorreta
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