title: Double-faceted mechanism of parvoviral oncosuppression.
abstract: The H-1 parvovirus (H-1PV) exerts oncosuppressive action that has two components: oncotoxicity and immunostimulation. While many human tumor cells, including conventional drug-resistant ones, can be killed by H-1PV, some fail to support progeny virus production, necessary for infection propagation in neoplastic tissues. This limitation can be overcome through forced selection of H-1PV variants capable of enhanced multiplication and spreading in human tumor cells. In the context of further developing H-1PV for use in cancer therapy, arming it with immunostimulatory CpG motifs under conditions preserving replication and oncolysis enhances its action as an anticancer vaccine adjuvant. A first clinical study of H-1PV treatment in glioma patients has yielded evidence of intratumoral synthesis of the viral oncotoxic protein NS1 and immune cell infiltration.
authors.affiliation: German Cancer Research Center, Infection and Cancer Program, Division of Tumor Virology, 69120 Heidelberg, Germany; Department of Neurosurgery, University Hospital, 69120 Heidelberg, Germany.
authors.forename: Karsten
authors.initials: K
authors.lastname: Geletneky
authors.affiliation: German Cancer Research Center, Infection and Cancer Program, Division of Tumor Virology, 69120 Heidelberg, Germany.
authors.forename: Jürg Pf
authors.initials: JP
authors.lastname: Nüesch
authors.affiliation: German Cancer Research Center, Infection and Cancer Program, Division of Tumor Virology, 69120 Heidelberg, Germany.
authors.forename: Assia
authors.initials: A
authors.lastname: Angelova
authors.affiliation: German Cancer Research Center, Infection and Cancer Program, Division of Tumor Virology, 69120 Heidelberg, Germany.
authors.forename: Irina
authors.initials: I
authors.lastname: Kiprianova
authors.affiliation: German Cancer Research Center, Infection and Cancer Program, Division of Tumor Virology, 69120 Heidelberg, Germany. Electronic address: j.rommelaere@dkfz.de.
authors.forename: Jean
authors.initials: J
authors.lastname: Rommelaere
mesh_terms: D018138:Alphaherpesvirinae / Q000235:genetics / Q000502:physiology*; D000818:Animals; D052661:H-1 parvovirus / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000628:therapy* / Q000821:virology; D050130:Oncolytic Virotherapy; D050504:Oncolytic Viruses / Q000235:genetics / Q000502:physiology*