title: Low-dose ramosetron accelerates gastric emptying in the early phase: A crossover study in healthy volunteers using a continuous real-time 13C breath test (BreathID System).
abstract: OBJECTIVE
  The aim of this study was to determine the correlation between low-dose ramosetron pre-treatment and gastric emptying using a novel, non-invasive technique for measuring gastric emptying, namely, the continuous real-time 13C breath test (BreathID system: Exalenz Bioscience Ltd., Israel).
  
  
  METHODS
  Twelve healthy male volunteers participated in this randomized two-way crossover study. The subjects fasted overnight and were randomly assigned to receive the test meal (200 kcal per 200 mL) after an hour pre-treatment with 5 µg ramosetron or the test meal alone. Gastric emptying was monitored for 4 hours after administration of the test meal with the 13C-acetic acid breath test performed continuously using the BreathID system. Using Oridion Research Software (β version), T 1/2, T lag, GEC and the regression-estimated constants (β and κ) were calculated. The differences in the parameters measured at two time-points were analyzed using Wilcoxon's signed-rank test.
  
  
  RESULTS
  There was a significant difference in the calculated parameter β. No significant differences in the calculated parameters T 1/2, T lag, GEC or κ were observed between the test meal with ramosetron group and the test meal alone group.
  
  
  CONCLUSIONS
  This study showed that ramosetron pre-treatment enhances the early gastric emptying of liquid nutrients.
authors.affiliation: Department of Medical Education, Yokohama City University Faculty of Medicine, Yokohama, Japan. inamorim@med.yokohama-cu.ac.jp.
authors.forename: Sho
authors.initials: S
authors.lastname: Inoue
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sekino
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Eiji
authors.initials: E
authors.lastname: Gotoh
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
mesh_terms: D000328:Adult; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D005746:Gastric Emptying / Q000187:drug effects*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D011897:Random Allocation; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D001562:Benzimidazoles; D002247:Carbon Isotopes; D012702:Serotonin Antagonists; C071315:ramosetron