title: Alopecia secondary to anti-tumor necrosis factor-alpha therapy.
abstract: Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti-TNF). Psoriasiform cutaneous reactions and few cases of alopecia can occur in some patients while taking these drugs. Two cases of alopecia were reported after anti-TNF therapy. Both also developed psoriasiform lesions on the body. This is the second report about a new entity described as 'anti-TNF therapy-related alopecia', which combines clinical and histopathological features of both alopecia areata and psoriatic alopecia. The recognition of these effects by specialists is essential for the proper management and guidance of these patients.
authors.affiliation: Faculdade de Medicina do ABC, São Paulo, SP, Brazil.
authors.forename: Lara Beatriz Prata
authors.initials: LB
authors.lastname: Ribeiro
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Juliana Carlos Gonçalves
authors.initials: JC
authors.lastname: Rego
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Bruna Duque
authors.initials: BD
authors.lastname: Estrada
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Paula Raso
authors.initials: PR
authors.lastname: Bastos
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Piñeiro Maceira
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Celso Tavares
authors.initials: CT
authors.lastname: Sodré
mesh_terms: D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000139:chemically induced* / Q000473:pathology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D003424:Crohn Disease / Q000188:drug therapy*; D046169:Dermoscopy; D003875:Drug Eruptions; D005260:Female; D006801:Humans; D000069285:Infliximab; D008297:Male; D011565:Psoriasis / Q000139:chemically induced* / Q000473:pathology; D012535:Scalp / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab
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