title: [Stereotactic body radiation radiotherapy for oligometastatic non-small cell lung cancer (NSCLC): A case report].
abstract: Metastatic non-small cell lung cancer is associated with a poor prognosis, and palliative chemotherapy is the mainstay of treatment. However, long-time survival has been observed in oligometastatic patients treated with locally ablative therapies to all sites of metastatic disease. An 80-year-old man was diagnosed with an adenocarcinoma of the lung. The right upper lobe lesion was classified cT2aN0M0 and was treated with stereotactic body radiation therapy at the dose of 60Gy in eight fractions. A few months after, he successively presented with two brain metastases and one left adrenal metastasis, with a complete response on the primary tumor. The three secondary lesions were treated with stereotactic body radiation therapy alone. Thirty months after the diagnosis and 12months after metastases' apparition, primary and brain lesion kept controlled (complete response). Oligometastatic non-small cell lung cancer management is not clear. Locally ablative therapies such as stereotactic body radiation therapy, surgery and radiofrequency are efficient and should be considered. A phase III study should evaluate radical treatment strategies in such patients.
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Pôle de pathologie respiratoire, service de pneumologie, centre hospitalier universitaire, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Leduc
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Fédération de médecine translationnelle de Strasbourg (FMTS), laboratoire EA 3430, université de Strasbourg, 67000 Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Antoni
authors.affiliation: Pôle de pathologie respiratoire, service de pneumologie, centre hospitalier universitaire, 1, place de l'Hôpital, BP 426, 67091 Strasbourg cedex, France.
authors.forename: É
authors.initials: É
authors.lastname: Quoix
authors.affiliation: Département universitaire de radiothérapie, centre Paul-Strauss, 3, rue de la Porte-de-l'Hôpital, BP 42, 67065 Strasbourg cedex, France; Fédération de médecine translationnelle de Strasbourg (FMTS), laboratoire EA 3430, université de Strasbourg, 67000 Strasbourg, France. Electronic address: gnoel@strasbourg.unicancer.fr.
authors.forename: G
authors.initials: G
authors.lastname: Noël
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D000310:Adrenal Gland Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D002278:Carcinoma in Situ / Q000601:surgery; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D010490:Pericardial Effusion / Q000209:etiology; D016634:Radiosurgery / Q000379:methods*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
keywords: Ablative therapy; CBNPC; Cancer bronchique non à petites cellules; NSCLC; Non-small cell lung cancer; Oligometastatic disease; Oligométastatique; Radiothérapie en conditions stéréotaxiques; SBRT; Stereotactic body radiation therapy; Traitement curatif