title: Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation.
abstract: We provide a framework for compensating errors within passive optical quadrature demodulation circuits used in swept-source optical coherence tomography (OCT). Quadrature demodulation allows for detection of both the real and imaginary components of an interference fringe, and this information separates signals from positive and negative depth spaces. To achieve a high extinction (∼60 dB) between these positive and negative signals, the demodulation error must be less than 0.1% in amplitude and phase. It is difficult to construct a system that achieves this low error across the wide spectral and RF bandwidths of high-speed swept-source systems. In a prior work, post-processing methods for removing residual spectral errors were described. Here, we identify the importance of a second class of errors originating in the RF domain, and present a comprehensive framework for compensating both spectral and RF errors. Using this framework, extinctions >60 dB are demonstrated. A stability analysis shows that calibration parameters associated with RF errors are accurate for many days, while those associated with spectral errors must be updated prior to each imaging session. Empirical procedures to derive both RF and spectral calibration parameters simultaneously and to update spectral calibration parameters are presented. These algorithms provide the basis for using passive optical quadrature demodulation circuits with high speed and wide-bandwidth swept-source OCT systems.
authors.forename: Meena
authors.initials: M
authors.lastname: Siddiqui
authors.forename: Serhat
authors.initials: S
authors.lastname: Tozburun
authors.forename: Ellen Ziyi
authors.initials: EZ
authors.lastname: Zhang
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Vakoc
mesh_terms: D000465:Algorithms; D002138:Calibration; D021621:Imaging, Three-Dimensional; D055620:Optical Phenomena; D011846:Radio Waves; D059629:Signal-To-Noise Ratio; D041623:Tomography, Optical Coherence / Q000379:methods*
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