title: Asymmetrical dimethylarginine promotes the senescence of human skin fibroblasts via the activation of a reactive oxygen species-p38 MAPK-microRNA-138 pathway.
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hong-Fu
authors.initials: HF
authors.lastname: Xie
authors.affiliation: Department of Dermatology, Hunan Loudi Hospital, Loudi, China.
authors.forename: Wen-Zhi
authors.initials: WZ
authors.lastname: Li
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ying-Xue
authors.initials: YX
authors.lastname: Huang
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. Electronic address: 569085332@qq.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Jian
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: lydia.1208@hotmail.com.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D001415:Back; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects*; D002648:Child; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005145:Face; D005347:Fibroblasts / Q000378:metabolism* / Q000528:radiation effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D020935:MAP Kinase Signaling System / Q000187:drug effects; D035683:MicroRNAs / Q000378:metabolism*; D008875:Middle Aged; D011725:Pyridines / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D015595:Skin Aging / Q000502:physiology; D014466:Ultraviolet Rays
chemical_list: D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D007093:Imidazoles; C546110:MIRN138 microRNA, human; D035683:MicroRNAs; D011725:Pyridines; D017382:Reactive Oxygen Species; C487735:dimethylarginine; D001120:Arginine; C093642:SB 203580; D000111:Acetylcysteine
keywords: ADMA; MMP-1; ROS; Skin senescence; miR-138; p38MAPK