title: A new biodegradable and biocompatible gadolinium (III) -polymer for liver magnetic resonance imaging contrast agent.
abstract: A new biodegradable and biocompatible gadolinium (III) -copolymer (ACL-A2-DOTA-Gd) has been developed as a potential liver magnetic resonance imaging (MRI) contrast agent. ACL-A2-DOTA-Gd consisted of a poly (aspartic acid-co-leucine) unit bound with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (Gd-DOTA) via the linkage of ethylenediamine. In vitro, the biodegradable experiment and cytotoxicity assay showed the biodegradability and biocompatibility of this gadolinium-polymer. ACL-A2-DOTA-Gd presented an increase in relaxivity of 2.4 times than the clinical Gd-DOTA. In vivo, gadolinium (III)-copolymer was mainly accumulated in the liver, and it could be excreted via the renal and hepatobiliary mechanism. The average enhancement of ACL-A2-DOTA-Gd (60.71±5.93%, 50-80 min) in liver was 2.62-fold greater than that of Gd-DOTA (23.16±3.55%, 10-30 min). ACL-A2-DOTA-Gd could be as a potential liver MRI contrast agent with a long time-window.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China; National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xue
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China.
authors.forename: Tianyan
authors.initials: T
authors.lastname: You
authors.affiliation: National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China. Electronic address: xjli@ciac.ac.cn.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Li
authors.affiliation: National Analytical Research Center of Electrochemistry and Spectroscopy,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin Street 5625, Changchun 130022, PR China.
authors.forename: Fengkui
authors.initials: F
authors.lastname: Pei
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005029:Ethylenediamines / Q000493:pharmacokinetics; D006571:Heterocyclic Compounds / Q000493:pharmacokinetics*; D006801:Humans; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging; D051379:Mice; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D011108:Polymers; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
chemical_list: D003287:Contrast Media; D005029:Ethylenediamines; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D011108:Polymers; C031234:ethylenediamine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
keywords: Biocompatibility; Gadolinium (III) -polymer; Liver; MRI contrast agent; Relaxivity