title: Effect of crystallinity and plasticizer on mechanical properties and tissue integration of starch-based materials from two botanical origins.
abstract: The application of starch-based materials for biomedical purposes has attracted significant interest due to their biocompatibility. The physical properties and crystal structure of materials based on potato starch (PS) and amylomaize starch (AMS) were studied under physiological conditions. PS plasticized with 20% glycerol presented the best mechanical properties with an elastic modulus of 1.6MPa and a weak swelling, remaining stable for 30 days. The in vitro cell viability of 3T3 cells after contact with extracts from PS and AMS with 20% glycerol is 72% and 80%, respectively. PS presented good tissue integration and no significant inflammation or foreign body response after 30 days intra-muscular implantation in a rat model, contrary to AMS. It was shown that glycerol plasticization favors a fast B-type crystallization of PS materials, enhancing their mechanical strength and durability, and making them a good candidate for bioresorbable and biocompatible materials for implantable medical devices.
authors.affiliation: INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, 44316 Nantes, France. Electronic address: diegoalejandro83@gmail.com.
authors.forename: Diego
authors.initials: D
authors.lastname: Velasquez
authors.affiliation: INSERM, U1148, Université Paris 13, Université Paris7, Sorbonne Paris Cité LVTS, 46, rue Henri Huchard, 75877 Paris, France. Electronic address: graciela.pavon@univ-paris13.fr.
authors.forename: Graciela
authors.initials: G
authors.lastname: Pavon-Djavid
authors.affiliation: INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, 44316 Nantes, France. Electronic address: laurent.chaunier@nantes.inra.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Chaunier
authors.affiliation: INSERM, U1148, Université Paris 13, Université Paris7, Sorbonne Paris Cité LVTS, 46, rue Henri Huchard, 75877 Paris, France; Université Paris 13, Sorbonne Paris Cité, Institut Universitaire de Technologie de Saint-Denis, Place du 8 mai 1945, 93206 Saint-Denis, France. Electronic address: anne.pelle@inserm.fr.
authors.forename: Anne
authors.initials: A
authors.lastname: Meddahi-Pellé
authors.affiliation: INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, 44316 Nantes, France. Electronic address: denis.lourdin@nantes.inra.fr.
authors.forename: Denis
authors.initials: D
authors.lastname: Lourdin
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D055119:Elastic Modulus; D005990:Glycerol / Q000737:chemistry; D008297:Male; D051379:Mice; D023421:Models, Animal; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D010968:Plasticizers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D011198:Solanum tuberosum / Q000737:chemistry / Q000378:metabolism; D013213:Starch / Q000737:chemistry* / Q000494:pharmacology; D003313:Zea mays / Q000737:chemistry / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D010968:Plasticizers; D013213:Starch; D005990:Glycerol
keywords: Biocompatibility; Crystallization; Mechanical properties; Starch