title: In Vitro Fertilization in Women With Inflammatory Bowel Disease Is as Successful as in Women From the General Infertility Population.
abstract: OBJECTIVE
  Inflammatory bowel disease (IBD) affects women of reproductive age, so there are concerns about its effects on fertility. We investigated the success of in vitro fertilization (IVF) in patients with IBD compared with the general (non-IBD) IVF population.
  
  
  METHODS
  We conducted a matched retrospective cohort study of female patients with IBD who underwent IVF from 1998 through 2011 at 2 tertiary care centers. Patients were matched 4:1 to those without IBD (controls). The primary outcome was the cumulative rate of live births after up to 6 cycles of IVF. Secondary outcomes included the proportion of patients who became pregnant and the rate of live births for each cycle.
  
  
  RESULTS
  Forty-nine patients with Crohn's disease (CD), 71 patients with ulcerative colitis (UC), 1 patient with IBD-unclassified, and 470 controls underwent IVF during the study period. The cumulative rate of live births was 53% for controls, 69% for patients with UC (P = .08 compared with controls), and 57% for patients with CD (P = .87 compared with controls). The incidence of pregnancy after the first cycle of IVF was similar among controls (40.9%), patients with UC (49.3%; P = .18), and patients with CD (42.9%; P = .79). Similarly, the incidence of live births after the first cycle of IVF was similar among controls (30.2%), patients with UC (33.8%; P = .54), and patients with CD (30.6%; P = .95).
  
  
  CONCLUSIONS
  Based on a matched cohort study, infertile women with IBD achieve a rate of live births after IVF that is comparable with those of infertile women without IBD.
authors.affiliation: Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
authors.forename: Sveta Shah
authors.initials: SS
authors.lastname: Oza
authors.affiliation: Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Vikas
authors.initials: V
authors.lastname: Pabby
authors.affiliation: Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Dodge
authors.affiliation: Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
authors.forename: Vasiliki A
authors.initials: VA
authors.lastname: Moragianni
authors.affiliation: Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
authors.forename: Michele R
authors.initials: MR
authors.lastname: Hacker
authors.affiliation: Department of Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Janis H
authors.initials: JH
authors.lastname: Fox
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.
authors.forename: Katharine
authors.initials: K
authors.lastname: Correia
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Stacey A
authors.initials: SA
authors.lastname: Missmer
authors.affiliation: Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
authors.forename: Yetunde
authors.initials: Y
authors.lastname: Ibrahim
authors.affiliation: Reproductive Endocrinology and Infertility, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Reproductive Endocrinology and Infertility, Boston IVF, Boston, Massachusetts.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Penzias
authors.affiliation: Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Robert
authors.initials: R
authors.lastname: Burakoff
authors.affiliation: Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Sonia
authors.initials: S
authors.lastname: Friedman
authors.affiliation: Department of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; Center for Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts. Electronic address: acheifet@bidmc.harvard.edu.
authors.forename: Adam S
authors.initials: AS
authors.lastname: Cheifetz
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000150:complications*; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D011247:Pregnancy; D012107:Research Design; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Crohn's Disease; In Vitro Fertilization; Reproduction; Ulcerative Colitis
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