title: Diffuse thyroid enlargement following metastasis of lung adenocarcinoma.
abstract: A 55-year-old man presented with a rapidly enlarging thyroid. He had been diagnosed with lung adenocarcinoma nine months earlier. Computed tomography (CT) and ultrasound (US) detected reticular cord-like structures, but no nodules, in the thyroid. A fine-needle aspiration biopsy (FNAB) of the thyroid revealed thyroglobulin-negative adenocarcinoma cells, thus establishing the diagnosis of diffuse thyroid metastases of lung cancer. Moreover, the fluid demonstrated milky chyliform effusion. This case suggests that the presence of reticular cord-like structures on US and CT may be a key imaging finding for the clinical diagnosis of diffuse thyroid metastases and that chyliform effusion may contribute to rapid goiter formation.
authors.affiliation: Department of Diabetes and Endocrinology, Osaka Red Cross Hospital, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Murakami
authors.forename: Masato
authors.initials: M
authors.lastname: Taki
authors.forename: Takuo
authors.initials: T
authors.lastname: Nambu
authors.forename: Tomoko
authors.initials: T
authors.lastname: Wakasa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kato
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Shin
authors.initials: S
authors.lastname: Yonemitsu
authors.forename: Seiji
authors.initials: S
authors.lastname: Muro
authors.forename: Shogo
authors.initials: S
authors.lastname: Oki
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000077192:Adenocarcinoma of Lung; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D017809:Fatal Outcome; D006042:Goiter / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000556:secondary*; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional
chemical_list: D019275:Radiopharmaceuticals; D013954:Thyroglobulin