title: Validation of the Toronto Psoriatic Arthritis Screen Version 2 (ToPAS 2).
abstract: OBJECTIVE
  We previously developed and performed an initial validation of a screening questionnaire, the Toronto Psoriatic Arthritis Screen (ToPAS), for psoriatic arthritis (PsA). In our original analysis, we found that the index constructed appeared to discriminate well between those with a confirmed diagnosis of PsA and those without PsA in various clinical settings. However, it was suggested that ToPAS would benefit from additional refinement to the questions and the scoring system, because items pertaining to axial involvement were not included in our original index. Subsequently, a second version of ToPAS was developed, ToPAS 2, which incorporated the suggested refinements. We aimed to validate ToPAS 2 as a screening instrument for PsA.
  
  
  METHODS
  ToPAS 2 was administered to 3 "diagnostic" groups of individuals - patients with PsA, patients with psoriasis, and healthy controls, and the data collected were analyzed.
  
  
  RESULTS
  It was found that the new version of ToPAS, ToPAS 2, again performed well, with the axial domain now featuring in the new scoring system. The constructed index, ToPAS2_cap, had an overall area under the receiver-operation curve of 0.910, with overall values of sensitivity and specificity, at a cutpoint of 8 (or 7), of 87.2% (92.0%) and 82.7% (77.2%), respectively.
  
  
  CONCLUSIONS
  ToPAS 2 shows much promise as a screening instrument for identifying PsA both in people with psoriasis and in individuals from the general population. Its performance against other proposed screening instruments for PsA should be evaluated in other clinics and for other study designs.
authors.affiliation: From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK; the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.B.D. Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health; V. Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; V.T. Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health; C.F. Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto; D.D. Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital.
authors.forename: Brian D M
authors.initials: BD
authors.lastname: Tom
authors.affiliation: From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK; the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.B.D. Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health; V. Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; V.T. Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health; C.F. Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto; D.D. Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital.
authors.forename: Vinod
authors.initials: V
authors.lastname: Chandran
authors.affiliation: From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK; the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.B.D. Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health; V. Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; V.T. Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health; C.F. Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto; D.D. Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital.
authors.forename: Vernon T
authors.initials: VT
authors.lastname: Farewell
authors.affiliation: From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK; the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.B.D. Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health; V. Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; V.T. Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health; C.F. Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto; D.D. Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital.
authors.forename: Cheryl F
authors.initials: CF
authors.lastname: Rosen
authors.affiliation: From the MRC Biostatistics Unit, UK Institute of Public Health, Cambridge, UK; the Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; Division of Dermatology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.B.D. Tom, PhD, MRC Biostatistics Unit, UK Institute of Public Health; V. Chandran, MBBS, MD, DM, PhD, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital; V.T. Farewell, PhD, MRC Biostatistics Unit, UK Institute of Public Health; C.F. Rosen, MD, FRCPC, Division of Dermatology, Toronto Western Hospital, University of Toronto; D.D. Gladman, MD, FRCPC, Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital. dafna.gladman@utoronto.ca.
authors.forename: Dafna D
authors.initials: DD
authors.lastname: Gladman
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012107:Research Design; D012680:Sensitivity and Specificity
keywords: EARLY DIAGNOSIS; PSORIASIS; PSORIATIC ARTHRITIS; SCREENING QUESTIONNAIRE