title: Mutual interaction between BCL6 and microRNAs in T cell differentiation.
abstract: The transcription factor B-cell CLL/lymphoma 6 (BCL6) and the regulatory factor microRNAs (miRNAs) are of great importance in the differentiation of T cell subsets. An increasing body of evidence has demonstrated that BCL6 and miRNAs can target one another and mutually adjust their expression in T cell subsets, such as T helper (Th)-2, Th17, CD8+ regulatory T (CD8+Treg) and T follicular helper (Tfh) cells. Here, we discuss the most recent advances and emerging concepts in how BCL6 and miRNAs regulate one another, and the effects of such mutual regulations on T cell subset differentiation.
authors.affiliation: a Institute of Immunology; PLA; Third Military Medical University ; Chongqing , PR China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Wei
authors.forename: Weiwu
authors.initials: W
authors.lastname: Gao
authors.forename: Yuzhang
authors.initials: Y
authors.lastname: Wu
authors.forename: Bing
authors.initials: B
authors.lastname: Ni
authors.forename: Yi
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D051560:Proto-Oncogene Proteins c-bcl-6; D016176:T-Lymphocyte Subsets / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: C084103:BCL6 protein, human; D004268:DNA-Binding Proteins; D035683:MicroRNAs; D051560:Proto-Oncogene Proteins c-bcl-6
keywords: BCL6; T lymphocyte; differentiation; interaction; miRNA
references.citation: Autoimmun Rev. 2011 May;10(7):369-74
references.pmid: 21195808
references.citation: J Transl Med. 2011;9:44
references.pmid: 21507256
references.citation: Cell. 2000 Mar 17;100(6):655-69
references.pmid: 10761931
references.citation: J Exp Med. 2000 Dec 4;192(11):1545-52
references.pmid: 11104797
references.citation: J Exp Med. 2000 Dec 4;192(11):1553-62
references.pmid: 11104798
references.citation: J Exp Med. 2001 Jun 18;193(12):1373-81
references.pmid: 11413192
references.citation: Science. 2003 Feb 14;299(5609):1057-61
references.pmid: 12522256
references.citation: Blood. 2003 Dec 1;102(12):4107-14
references.pmid: 12893750
references.citation: Cell. 2004 Jan 23;116(2):281-97
references.pmid: 14744438
references.citation: Cell. 1997 May 16;89(4):587-96
references.pmid: 9160750
references.citation: Int Immunol. 1998 Jun;10(6):775-83
references.pmid: 9678758
references.citation: J Exp Med. 1999 Oct 18;190(8):1123-34
references.pmid: 10523610
references.citation: J Exp Med. 2004 Nov 1;200(9):1123-34
references.pmid: 15520244
references.citation: J Exp Med. 2010 Mar 15;207(3):475-89
references.pmid: 20212066
references.citation: Cell. 2010 Mar 19;140(6):777-83
references.pmid: 20303868
references.citation: Immunity. 2010 Apr 23;32(4):568-80
references.pmid: 20381385
references.citation: J Clin Immunol. 2010 May;30(3):347-57
references.pmid: 20393792
references.citation: J Immunol. 2010 Jul 15;185(2):823-33
references.pmid: 20543104
references.citation: ScientificWorldJournal. 2010;10:1239-43
references.pmid: 20602081
references.citation: J Neuroimmunol. 2010 Sep 14;226(1-2):165-71
references.pmid: 20637509
references.citation: Nature. 2010 Sep 16;467(7313):328-32
references.pmid: 20844537
references.citation: Immunol Rev. 2013 May;253(1):5-11
references.pmid: 23550634
references.citation: Immunol Rev. 2013 May;253(1):53-64
references.pmid: 23550638
references.citation: Immunol Rev. 2013 May;253(1):82-96
references.pmid: 23550640
references.citation: J Immunol. 2013 Jun 15;190(12):5972-80
references.pmid: 23686497
references.citation: Invest Ophthalmol Vis Sci. 2013 Jun;54(6):4017-25
references.pmid: 23674757
references.citation: Nat Immunol. 2013 Aug;14(8):777-84
references.pmid: 23867934
references.citation: Nat Rev Immunol. 2013 Sep;13(9):666-78
references.pmid: 23907446
references.citation: Nat Immunol. 2014 Apr;15(4):393-401
references.pmid: 24608041
references.citation: Cancer Genet. 2014 Mar;207(3):87-93
references.pmid: 24674866
references.citation: J Biol Chem. 2014 May 2;289(18):12446-56
references.pmid: 24644282
references.citation: Nat Commun. 2014;5:3904
references.pmid: 24887457
references.citation: J Immunol. 2014 Jun 15;192(12):5599-609
references.pmid: 24842756
references.citation: Trends Pharmacol Sci. 2014 Oct;35(10):493-500
references.pmid: 25131183
references.citation: Immunity. 2009 Sep 18;31(3):457-68
references.pmid: 19631565
references.citation: Cancer Lett. 2009 Nov 28;285(2):116-26
references.pmid: 19464788
references.citation: Nat Immunol. 2009 Dec;10(12):1252-9
references.pmid: 19838199
references.citation: Hepatology. 2010 Mar;51(3):836-45
references.pmid: 20041405
references.citation: J Immunol. 2005 Jun 1;174(11):7292-301
references.pmid: 15905576
references.citation: J Biol Chem. 2005 Aug 19;280(33):29409-19
references.pmid: 15975924
references.citation: Retrovirology. 2005;2:81
references.pmid: 16381609
references.citation: J Immunol. 2006 Sep 1;177(5):2775-83
references.pmid: 16920912
references.citation: Cell. 2006 Sep 22;126(6):1121-33
references.pmid: 16990136
references.citation: Nature. 2007 Feb 22;445(7130):936-40
references.pmid: 17237761
references.citation: Genes Dev. 2007 Mar 1;21(5):578-89
references.pmid: 17344418
references.citation: Proc Natl Acad Sci U S A. 2007 May 8;104(19):8029-34
references.pmid: 17483450
references.citation: Immunity. 2007 Aug;27(2):190-202
references.pmid: 17723214
references.citation: Mol Cancer. 2007;6:60
references.pmid: 17894887
references.citation: Eur J Immunol. 2008 Mar;38(3):640-6
references.pmid: 18266270
references.citation: Nat Immunol. 2008 Apr;9(4):405-14
references.pmid: 18327259
references.citation: Diabetes. 2008 Jul;57(7):1878-86
references.pmid: 18420485
references.citation: Hum Immunol. 2008 Nov;69(11):715-20
references.pmid: 18817830
references.citation: Retrovirology. 2008;5:118
references.pmid: 19114009
references.citation: J Immunol. 2009 Mar 1;182(5):2578-82
references.pmid: 19234151
references.citation: J Autoimmun. 2009 May-Jun;32(3-4):246-53
references.pmid: 19345069
references.citation: Immunity. 2009 May;30(5):744-52
references.pmid: 19446474
references.citation: Lab Invest. 2009 Jun;89(6):708-16
references.pmid: 19349957
references.citation: Eur J Immunol. 2009 Jun;39(6):1608-18
references.pmid: 19408243
references.citation: Eur J Immunol. 2009 Aug;39(8):2106-19
references.pmid: 19609979
references.citation: Nat Rev Immunol. 2011 Jun;11(6):375-88
references.pmid: 21610741
references.citation: Nat Immunol. 2011 Jul;12(7):597-606
references.pmid: 21685955
references.citation: Nat Immunol. 2011 Aug;12(8):796-803
references.pmid: 21706005
references.citation: Immunity. 2011 Aug 26;35(2):169-81
references.pmid: 21820330
references.citation: Blood. 2011 Nov 17;118(20):5487-97
references.pmid: 21972292
references.citation: Oral Dis. 2012 Mar;18(2):127-31
references.pmid: 21895886
references.citation: J Immunol. 2012 Apr 1;188(7):3042-52
references.pmid: 22387553
references.citation: Annu Rev Immunol. 2012;30:295-312
references.pmid: 22224773
references.citation: Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1248-57
references.pmid: 22517757
references.citation: Nat Immunol. 2012 Jun;13(6):587-95
references.pmid: 22544395
references.citation: Eur J Immunol. 2012 Aug;42(8):2100-8
references.pmid: 22585398
references.citation: Mol Immunol. 2013 Jul;54(3-4):435-42
references.pmid: 23416424
references.citation: BMC Musculoskelet Disord. 2010;11:209
references.pmid: 20840794
references.citation: Immunity. 2010 Oct 29;33(4):607-19
references.pmid: 20888269
references.citation: J Immunol. 2010 Nov 15;185(10):5714-22
references.pmid: 20935202
references.citation: Blood. 2010 Dec 2;116(23):e118-27
references.pmid: 20733160
references.citation: Ann Rheum Dis. 2011 Mar;70 Suppl 1:i92-6
references.pmid: 21339228
references.citation: Annu Rev Immunol. 2011;29:621-63
references.pmid: 21314428