title: Amisulpride augmentation for clozapine-refractory positive symptoms: additional benefit in reducing hypersialorrhea.
abstract: One-third to half of patients taking clozapine suffer from refractory symptoms despite adequate treatment. Among other adverse effects, clozapine-induced hypersalivation (CIH) occurs in approximately half of all patients. This is a case of a 30-year-old male with refractory schizophrenia; in this patient, the remission of residual positive symptoms, as well as the reduction of CIH, was achieved by treatment with clozapine augmented with amisulpride.
authors.affiliation: Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil.
authors.forename: Fabiani
authors.initials: F
authors.lastname: Bogorni
authors.affiliation: Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil.
authors.forename: Frederico Fernandes
authors.initials: FF
authors.lastname: Moreira
authors.affiliation: Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil.
authors.forename: Eduardo Mylius
authors.initials: EM
authors.lastname: Pimentel
authors.affiliation: Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil.
authors.forename: Géder Evandro Motta
authors.initials: GE
authors.lastname: Grohs
authors.affiliation: Programa de Residência Médica em Psiquiatria do Instituto de Psiquiatria de Santa Catarina (IPQ/SC), 88.123-300 São José, SC, Brazil ; Centro de Neurociências Aplicadas, Universidade Federal de Santa Catarina, 88.040-970 Florianópolis, SC, Brazil.
authors.forename: Alexandre Paim
authors.initials: AP
authors.lastname: Diaz
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