title: Josef Rudinger Memorial Lecture: Use of peptides to modulate protein-protein interactions.
abstract: Peptides are destined to play a major role as therapeutic agents. My laboratory is contributing to speeding up this process. On the one hand, we devote efforts to studying the molecular details and dynamics of the events that occur during molecular recognition at protein surfaces. We succeeded to design and synthesize peptides able to modulate these recognition events either permanently or in response to light. On the other hand, we are discovering and designing peptides able to cross biological barriers. Our aim is to use these peptides as shuttles for targeting therapeutic agents to organs, tissues, or cells, with a special emphasis on drug delivery to the brain.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028, Barcelona, Spain.|Department of Organic Chemistry, University of Barcelona, Marti Franqués 1, 08028, Barcelona, Spain.
authors.forename: Ernest
authors.initials: E
authors.lastname: Giralt
mesh_terms: D001812:Blood-Brain Barrier / Q000378:metabolism; D001927:Brain Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008027:Light; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D011485:Protein Binding / Q000187:drug effects*; D060066:Protein Interaction Maps
chemical_list: D010455:Peptides
keywords: NMR; blood brain barrier; drug design; peptide; protein-protein interaction