title: Complex of rutin with β-cyclodextrin as potential delivery system.
abstract: This study aimed to obtain and characterize an RU-β-CD complex in the context of investigating the possibility of changes in the solubility, stability, antioxidative and microbiological activity as well as permeability of complexated rutin as against its free form. The formation of the RU-β-CD complex via a co-grinding technique was confirmed by using DSC, SEM, FT-IR and Raman spectroscopy, and its geometry was assessed through molecular modeling. It was found that the stability and solubility of the so-obtained complex were greater compared to the free form; however, a slight decrease was observed inits antibacterial potency. An examination of changes in the EPR spectra of thecomplex excluded any reducing effect of complexation on the antioxidative activity of rutin. Considering the prospect of preformulation studies involving RU-β-CD complexes, of significance is also the observed possibility of prolongedly releasing rutin from the complex at a constant level over along period of 20 h, and the fact that twice as much complexated rutin was able topermeate compared to its free form.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Paczkowska
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Mizera
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Piotrowska
authors.affiliation: Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, Poznan, Poland.
authors.forename: Daria
authors.initials: D
authors.lastname: Szymanowska-Powałowska
authors.affiliation: Department of Molecular Crystals, Institute of Molecular Physics, Polish Academy Sciences, Poznan, Poland.
authors.forename: Kornelia
authors.initials: K
authors.lastname: Lewandowska
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University in Poznan, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Goscianska
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University in Poznan, Poznan, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Pietrzak
authors.affiliation: Department of Solid State Radiospectroscopy, Institute of Molecular Physics, Polish Academy Sciences, Poznan, Poland.
authors.forename: Waldemar
authors.initials: W
authors.lastname: Bednarski
authors.affiliation: Adamed Sp. z o.o., Czosnów near Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Majka
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Judyta
authors.initials: J
authors.lastname: Cielecka-Piontek
mesh_terms: D002152:Calorimetry, Differential Scanning / Q000379:methods; D008958:Models, Molecular; D012431:Rutin / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods; D014961:X-Ray Diffraction / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D047392:beta-Cyclodextrins; D012431:Rutin; C031215:betadex
references.citation: J Agric Food Chem. 2003 Oct 22;51(22):6452-5
references.pmid: 14558761
references.citation: Int J Pharm. 2014 Oct 20;474(1-2):80-90
references.pmid: 25128698
references.citation: Microbiol Res. 2010 Aug 20;165(6):496-504
references.pmid: 19840899
references.citation: Carbohydr Polym. 2012 Nov 6;90(4):1764-70
references.pmid: 22944445
references.citation: J Agric Food Chem. 2000 Sep;48(9):3830-8
references.pmid: 10995278
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:331-6
references.pmid: 24317259
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2003 Dec;59(14):3421-9
references.pmid: 14607238
references.citation: Phytochemistry. 2013 Sep;93:49-62
references.pmid: 23566717
references.citation: Food Chem. 2013 Dec 15;141(4):4194-9
references.pmid: 23993605
references.citation: Food Chem. 2013 Jan 1;136(1):186-92
references.pmid: 23017411