title: [Special mechanisms for reducing life span of cells and organisms, initiated by some weak external signals].
abstract: The study presents the results of many-years research conducted using biological objects of different organization level. It demonstrates special species-nonspecific form of weak external signals negative effect to cells life expectancy reduction caused by program damage of cells populations. This effect is detected after weak radiation, radio-chemical and thermal influences. It leads to faster extinction of postmitotic populations which can be a reason for life expectancy reduction of multicellular organisms. A possibility of such effect inheritance in the asexual and sexual reproduction is shown. Epigenetic mechanisms of this phenomenon are assumed.
authors.forename: I B
authors.initials: IB
authors.lastname: Bychkovskaia
authors.forename: R F
authors.initials: RF
authors.lastname: Fedortseva
mesh_terms: D000375:Aging / Q000235:genetics / Q000528:radiation effects; D000818:Animals; D018929:Cell Culture Techniques; D016923:Cell Death / Q000235:genetics / Q000528:radiation effects; D016922:Cellular Senescence / Q000235:genetics / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000528:radiation effects; D011829:Radiation Dosage; D012098:Reproduction / Q000235:genetics / Q000528:radiation effects; D014965:X-Rays