title: [The association of polymorphisms in SLC18A1, TPH1 and RELN genes with risk of paranoid schizophrenia].
abstract: We have developed a biochip for the analysis of polymorphisms in candidate genes for schizophrenia: DISC1, RELN, ZNF804A, PLXNA2, COMT, SLC18A41, CACNA1C, ANK3, TPH1, PLAA and SNAP-25. Using biochip the allele and genotype frequencies in 198 patients with schizophrenia and 192 healthy individuals have been obtained. For SLC18A1 polymorphism rs2270641 A>C, the frequencies of A allele (p = 0.007) and AA genotype (p = 0.002) were lower in patients compared with healthy individuals. A significant association was found between AA genotype (p = 0.036) of the TPH1 polymorphism rs1800532 C>A and schizophrenia. The C allele (p = 0.039) of the RELNpolymorphism rs7341475 C>T were lower in patients with schizophrenia compared with healthy individuals in a tatar population. Genotype AA of the TPH1 polymorphism rs1800532 C>A were more frequent in patients with schizophrenia compared with healthy individuals. Ithas been shown that the C allele (p = 0.0001) and GC (p = = 0.0001) genotype of the PLXNA2 polymorphism rs1327175 G>C are associated with the family history in patients with paranoid schizophrenia. The obtained data suggest that SLC18A1, TPH1 and RELN gene polymorphisms are associated with the risk of paranoid schizophrenia.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Galaktionova
authors.forename: A E
authors.initials: AE
authors.lastname: Gareeva
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: T V
authors.initials: TV
authors.lastname: Nasedkina
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000091042:Reelin Protein; D012563:Schizophrenia, Paranoid / Q000235:genetics*; D012697:Serine Endopeptidases / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C493449:SLC18A1 protein, human; D050493:Vesicular Monoamine Transport Proteins; C497467:TPH1 protein, human; D014365:Tryptophan Hydroxylase; C000717127:RELN protein, human; D012697:Serine Endopeptidases