title: Immunohistochemical Study of Aquaporins in an African Grey Parrot (Psittacus erithacus) With Hydrocephalus.
abstract: A 5-month-old African grey parrot (Psittacus erithacus) was examined after 3 weeks of weakness, ataxia, mental depression, and seizures. Results of a complete blood cell count and plasma biochemical analysis were unremarkable. Magnetic resonance imaging revealed a severe bilateral hydrocephalus. The bird failed to improve with supportive care, and the owner requested euthanasia. Necropsy findings were severe bilateral hydrocephalus with no evidence of cerebrospinal fluid obstruction. Histologic examination of the brain revealed microspongiosis, edema, gliosis, and neuronal chromatolysis of surrounding periventricular tissue. Aquaporins (AQP) and astrocytes were examined to elucidate the participation of these water channel proteins and glial cells in the pathophysiology and resolution of hydrocephalus. Results showed AQP4 and glial fibrillary acidic protein were overexpressed, especially near the ventricles, but expression of AQP1 was decreased. This is the first report, to our knowledge, of AQP immunolabeling in hydrocephalus in avain species.
authors.forename: Ester
authors.initials: E
authors.lastname: Blasco
authors.forename: Jaime
authors.initials: J
authors.lastname: Martorell
authors.forename: Cristian
authors.initials: C
authors.lastname: De la Fuente
authors.forename: Martí
authors.initials: M
authors.lastname: Pumarola
keywords: AQP; African grey parrot; CSF; Psittacus erithacus; aquaporin; avian; cerebrospinal fluid; hydrocephalus