title: Mycobacterium tuberculosis effectors interfering host apoptosis signaling.
abstract: Tuberculosis remains a serious human public health concern. The coevolution between its pathogen Mycobacterium tuberculosis and human host complicated the way to prevent and cure TB. Apoptosis plays subtle role in this interaction. The pathogen endeavors to manipulate the apoptosis via diverse effectors targeting key signaling nodes. In this paper, we summarized the effectors pathogen used to subvert the apoptosis, such as LpqH, ESAT-6/CFP-10, LAMs. The interplay between different forms of cell deaths, such as apoptosis, autophagy, necrosis, is also discussed with a focus on the modes of action of effectors, and implications for better TB control.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Three Gorges Eco-Environment and Bioresources, Eco-Environment Key Laboratory of the Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Chongqing, 400715, China, 709729072@qq.com.
authors.forename: Minqiang
authors.initials: M
authors.lastname: Liu
authors.forename: Wu
authors.initials: W
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xiang
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D000942:Antigens, Bacterial / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001343:Autophagy / Q000187:drug effects; D016207:Cytokines / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D009336:Necrosis / Q000378:metabolism; D015398:Signal Transduction; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
chemical_list: D000942:Antigens, Bacterial; D051017:Apoptosis Regulatory Proteins; D016207:Cytokines