title: Molecular epidemiology and antibiotic susceptibility pattern of Acinetobacter baumannii isolated from children in a Turkish university hospital.
abstract: The aim of the present study is to investigate the types of healthcare-associated infections (HC-AIs) caused by Acinetobacter baumannii and the related antibiotic susceptibility patterns as well as the genotypic characteristics of the Acinetobacter baumannii isolates from our center. Sixty-nine Acinetobacter baumannii isolates originating from various samples collected from 69 pediatric patients during their hospital stays were included in the study. The types of healthcare-associated infections caused by these isolates were evaluated, and the antibiotic susceptibility pattern and the genotypic characteristics of the isolates were determined using the pulsed-field gel electrophoresis (PFGE) method. Fifty of the 69 children were observed to have HC-AIs, and 19 children had Acinetobacter baumannii colonization. Healthcare-associated pneumonia (58%) was the most common type of these infections. The rate of carbapenem resistance was found as 91.3%, while tigecycline resistance was found as 18.84%. No colistin resistance was observed in any of the isolates. A total of 10 groups, comprising eight major and two minor groups, were determined using the pulsed-field gel electrophoresis method. Acinetobacter baumannii isolates are the leading cause of healthcare-associated infections, and they show high rates of multidrug antibiotic resistance. Molecular epidemiological evaluation using PFGE plays an important role in preventing healthcare-associated infections.
authors.affiliation: Division of Pediatric Infectious Diseases, Department of Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkey. ozlemozgur1978@yahoo.com.
authors.forename: Özlem Özgür
authors.initials: ÖÖ
authors.lastname: Gündeşlioğlu
authors.forename: Tülin Güven
authors.initials: TG
authors.lastname: Gökmen
authors.forename: Özden Özgür
authors.initials: ÖÖ
authors.lastname: Horoz
authors.forename: Necmi
authors.initials: N
authors.lastname: Aksaray
authors.forename: Fatih
authors.initials: F
authors.lastname: Köksal
authors.forename: Akgün
authors.initials: A
authors.lastname: Yaman
authors.forename: Rıza Dinçer
authors.initials: RD
authors.lastname: Yıldızdaş
authors.forename: Emre
authors.initials: E
authors.lastname: Alhan
authors.forename: Emine
authors.initials: E
authors.lastname: Kocabaş
authors.forename: Derya
authors.initials: D
authors.lastname: Alabaz
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents