title: Predictive value of biomarkers for the prognosis of acute pulmonary embolism in Japanese patients: Results of the Tokyo CCU Network registry.
abstract: BACKGROUND
  Several studies from Western countries have reported associations between cardiac troponin and B-type natriuretic peptide (BNP) levels and acute pulmonary embolism prognosis; however, the number of such reports from Asian countries, including Japan, is limited. Thus, we evaluated the relationship between blood biochemical findings and acute-phase pulmonary embolism prognosis in Japanese patients.
  
  
  METHODS
  The subjects included 441 patients with acute pulmonary embolism (191 men, 250 women; average age, 65.8±16.0 years) treated at Tokyo CCU Network Institutions from 2009 to 2011 and registered via survey forms. The association between blood biochemical findings at admission and 30-day mortality was investigated.
  
  
  RESULTS
  The median BNP value was 186.5pg/mL (25th to 75th interquartile range: 49.8-500pg/mL) of 210 cases. No deaths were recorded among those with BNP levels <90pg/mL (n=70), whereas significantly higher mortality (10 deaths/140 cases, 7.1%; p=0.033) was observed among those with BNP levels ≥90pg/mL. A qualitative cardiac troponin test was positive in 58 of the 204 cases (28.4%), with a significantly higher mortality incidence (p=0.017) among the troponin-positive cases [6 (10.3%) versus 3 (2.1%) deaths among the 146 troponin-negative cases]. The overall mean blood glucose level at admission of 331 cases was 152.0±74.0mg/dL, and 30-day mortality significantly increased with blood glucose values (p=0.048).
  
  
  CONCLUSIONS
  Troponin, BNP, and blood glucose levels are useful prognostic biomarkers for acute pulmonary embolism in Japanese patients.
authors.affiliation: Tokyo CCU Network Scientific Committee, Tokyo, Japan. Electronic address: y-tanabe@muj.biglobe.ne.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tanabe
authors.affiliation: Tokyo CCU Network Scientific Committee, Tokyo, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Obayashi
authors.affiliation: Tokyo CCU Network Scientific Committee, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Tokyo CCU Network Scientific Committee, Tokyo, Japan.
authors.forename: Morimasa
authors.initials: M
authors.lastname: Takayama
authors.affiliation: Tokyo CCU Network Scientific Committee, Tokyo, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Nagao
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis*; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D011655:Pulmonary Embolism / Q000097:blood* / Q000401:mortality; D012042:Registries; D014041:Tokyo; D014336:Troponin / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014336:Troponin; D020097:Natriuretic Peptide, Brain
keywords: B-type natriuretic peptide; Blood biomarkers; Hyperglycemia; Pulmonary embolism; Troponin