title: Utility of peripheral blood parameters in predicting breast cancer risk.
abstract: OBJECTIVE
  We aimed to study the inflammatory parameters of complete blood count in breast cancer cases.
  
  
  METHODS
  This retrospective study covered 178 breast cancer patients and 107 age and body mass index matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/ lymphocyte ratio (PLR) and MPV/platelet were analyzed.
  
  
  RESULTS
  The leukocyte, neutrophil and neutrophil/ lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) while haemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysis showed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001 and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cut- off value for the neutrophil/lymphocyte ratio was 2.56.
  
  
  CONCLUSIONS
  According to our study results, neutrophil levels as part of complete blood count may be used as an independent predictor of breast cancer risk.
authors.affiliation: Internal Medicine, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey E-mail : y.okuturlar@gmail.com.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Okuturlar
authors.forename: Meral
authors.initials: M
authors.lastname: Gunaldi
authors.forename: Elif Eda
authors.initials: EE
authors.lastname: Tiken
authors.forename: Bugra
authors.initials: B
authors.lastname: Oztosun
authors.forename: Yesim Ozdem
authors.initials: YO
authors.lastname: Inan
authors.forename: Tarik
authors.initials: T
authors.lastname: Ercan
authors.forename: Savas
authors.initials: S
authors.lastname: Tuna
authors.forename: Ali Osman
authors.initials: AO
authors.lastname: Kaya
authors.forename: Ozlem
authors.initials: O
authors.lastname: Harmankaya
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Kumbasar
mesh_terms: D001772:Blood Cell Count / Q000706:statistics & numerical data*; D001792:Blood Platelets / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000209:etiology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000209:etiology; D018275:Carcinoma, Lobular / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies