title: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group Report.
abstract: The 2006 National Institutes of Health (NIH) Consensus paper presented recommendations by the Ancillary Therapy and Supportive Care Working Group to support clinical research trials in chronic graft-versus-host disease (GVHD). Topics covered in that inaugural effort included the prevention and management of infections and common complications of chronic GVHD, as well as recommendations for patient education and appropriate follow-up. Given the new literature that has emerged during the past 8 years, we made further organ-specific refinements to these guidelines. Minimum frequencies are suggested for monitoring key parameters relevant to chronic GVHD during systemic immunosuppressive therapy and, thereafter, referral to existing late effects consensus guidelines is advised. Using the framework of the prior consensus, the 2014 NIH recommendations are organized by organ or other relevant systems and graded according to the strength and quality of supporting evidence.
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: pcarpent@fredhutch.org.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Carpenter
authors.affiliation: Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Kitko
authors.affiliation: Division of Oral Medicine, Eastman Institute for Oral Health and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York.
authors.forename: Sharon
authors.initials: S
authors.lastname: Elad
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Mary E D
authors.initials: ME
authors.lastname: Flowers
authors.affiliation: Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Juan C
authors.initials: JC
authors.lastname: Gea-Banacloche
authors.affiliation: Department of Hematology, University Hospital Basel, Basel, Switzerland.
authors.forename: Jörg P
authors.initials: JP
authors.lastname: Halter
authors.affiliation: Department of Psychology, Eastern Michigan University, Ypsilanti, Michigan.
authors.forename: Flora
authors.initials: F
authors.lastname: Hoodin
authors.affiliation: Department of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, California.
authors.forename: Laura
authors.initials: L
authors.lastname: Johnston
authors.affiliation: St. Anna Children's Hospital, Medical University, Vienna, Austria.
authors.forename: Anita
authors.initials: A
authors.lastname: Lawitschka
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: George B
authors.initials: GB
authors.lastname: McDonald
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan.
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Opipari
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital and University of BC, Vancouver, British Columbia.
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Schultz
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan.
authors.forename: Sean R
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Syrjala
authors.affiliation: Division of Oral Medicine and Dentistry, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Treister
authors.affiliation: Oncology Department, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Georgia B
authors.initials: GB
authors.lastname: Vogelsang
authors.affiliation: Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Kirsten M
authors.initials: KM
authors.lastname: Williams
authors.affiliation: Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
authors.forename: Steven Z
authors.initials: SZ
authors.lastname: Pavletic
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Martin
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Couriel
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D000075202:Contraindications; D019468:Disease Management; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D019337:Hematologic Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017319:Photosensitizing Agents; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D014184:Transplantation, Homologous
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D017319:Photosensitizing Agents
keywords: Allogeneic hematopoietic cell transplantation; Chronic graft-versus-host disease; Consensus; Guidelines; Supportive care
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