title: Intraocular lens power changes after mitomycin trabeculectomy.
abstract: OBJECTIVE
  To evaluate biometric changes after mitomycin C augmented trabeculectomy and their effect on intraocular lens (IOL) power calculation using different formulas.
  
  
  METHODS
  In this prospective, interventional case series study, 34 eyes of 31 phakic glaucoma patients who were scheduled for primary trabeculectomy were enrolled. Using a noncontact biometry device (Lenstar, Haag-Streit AG, Koeniz, Switzerland), axial length (AL), mean corneal power, and IOL power were calculated with the Hoffer Q, Holladay, and SRK/T formulas 1 day before surgery and compared to those obtained 3 and 6 months after the operation. Bland-Altman plot was used to determine agreement between preoperative and postoperative IOL power values.
  
  
  RESULTS
  The AL was significantly decreased at month 3 (-0.14 ± 0.13 mm) and month 6 (-0.14 ± 0.15 mm) as compared to baseline values (both p values &lt;0.001). Mean corneal power increased significantly at month 3 (0.41 ± 0.46 D; p&lt;0.001) and month 6 (0.27 ± 0.47 D; p = 0.008). Using different formulas, IOL power did not change significantly after the operation (all ps≥0.17). The IOL power changes using the Hoffer Q formula were -0.09 ± 0.76 (p = 0.505) and 0.14 ± 0.9 D (p = 0.442) at 3 and 6 months, respectively; corresponding values were -0.1 ± 0.75 (p = 0.427) and 0.16 ± 0.79 D (p = 0.319) for Holladay and 0.01 ± 0.64 (p = 0.895) and 0.2 ± 0.71 D (p = 0.17) employing the SRK/T formula.
  
  
  CONCLUSIONS
  Despite significant changes in AL and corneal power after trabeculectomy, IOL power calculation remains unchanged; therefore adjustment of IOL power calculation after trabeculectomy seems unnecessary.
authors.affiliation: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Pakravan
authors.affiliation: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
authors.forename: Azam
authors.initials: A
authors.lastname: Alvani
authors.affiliation: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
authors.forename: Shahin
authors.initials: S
authors.lastname: Yazdani
authors.affiliation: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Esfandiari
authors.affiliation: Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran - Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yaseri
mesh_terms: D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage*; D001699:Biometry; D003131:Combined Modality Therapy; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D055095:Optics and Photonics; D011184:Postoperative Period; D011446:Prospective Studies; D014130:Trabeculectomy / Q000379:methods*; D055815:Young Adult
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin