title: Synthesis and biological activity of arylspiroborate salts derived from caffeic Acid phenethyl ester.
abstract: Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether chelation to boron improves their biological activity. Sodium salt 4 was generally more active than ammonium salt 5 in the biological assays and surpassed the radical scavenging ability of CAPE. Compounds 4 and 5 were more active than CAPE and Zileuton in human polymorphonuclear leukocytes. These results clearly show the effectiveness of the synthesized salts as transporter of CAPE.
authors.affiliation: Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
authors.forename: Martin J G
authors.initials: MJ
authors.lastname: Hébert
authors.affiliation: Department of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Flewelling
authors.affiliation: Department of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
authors.forename: Trevor N
authors.initials: TN
authors.lastname: Clark
authors.affiliation: Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
authors.forename: Natalie A
authors.identifier: 0000-0003-2383-8167
authors.initials: NA
authors.lastname: Levesque
authors.affiliation: Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
authors.forename: Jacques
authors.initials: J
authors.lastname: Jean-François
authors.affiliation: Department of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5.
authors.forename: Marc E
authors.initials: ME
authors.lastname: Surette
authors.affiliation: Department of Biology, University of New Brunswick, Saint John, NB, Canada E2L 4L5 ; Department of Chemistry, University of New Brunswick, Fredericton, NB, Canada E3B 5A3.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
authors.affiliation: Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada E4L 1G8.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Vogels
authors.affiliation: Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Touaibia
authors.affiliation: Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada E4L 1G8.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Westcott
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