title: Characterization of patients with cystic fibrosis presenting an indeterminate glucose tolerance (INDET).
abstract: BACKGROUND
  CFRD is preceded and associated with a significantly increased morbidity and mortality. We aimed to characterize a large newly established glucose tolerance subgroup named INDET (indeterminate; 1-h oral glucose tolerance test (OGTT)>11.0 but 2h-OGTT<7.8 mmol/L) in adult patients with cystic fibrosis (CF).
  
  
  METHODS
  All CF participants (n=252, ≥18 yrs without CFRD) underwent a 2h-OGTT with glucose and insulin sample measurements every 30 min. They were then classified as having either normal, impaired, or INDET glucose tolerance, or de novo CFRD. Other clinical characteristics were collected such as the BMI and pulmonary function.
  
  
  RESULTS
  All groups were of similar age (P=0.629) and BMI (P=0.813). We found that the INDETs displayed decreased lung function comparable to de novo CFRD. OGTT-derived glucose or insulin secretion/sensitivity parameters cannot fully explain this observation.
  
  
  CONCLUSIONS
  Prospective studies are required to establish if the INDET-CF group can identify clinically relevant outcomes.
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada.
authors.forename: Adèle
authors.initials: A
authors.lastname: Coriati
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada.
authors.forename: Sophie
authors.initials: S
authors.lastname: Ziai
authors.affiliation: Department of Medicine, Université de Montréal, Montréal, Québec H3T1J4, Canada.
authors.forename: Mirna
authors.initials: M
authors.lastname: Azar
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada; Department of Medicine, Université de Montréal, Montréal, Québec H3T1J4, Canada.
authors.forename: Yves
authors.initials: Y
authors.lastname: Berthiaume
authors.affiliation: Institut de Recherches Cliniques de Montréal, Montréal, Québec H2W 1R7, Canada; Department of Nutrition, Université de Montréal, Montréal, Québec H3T 1A8, Canada; Cystic Fibrosis Clinic of the Centre hospitalier de l'Université de Montréal, Montréal, Québec H2W 1T8, Canada; Department of Medicine, Université de Montréal, Montréal, Québec H3T1J4, Canada. Electronic address: remi.rabasa-lhoret@ircm.qc.ca.
authors.forename: Rémi
authors.initials: R
authors.lastname: Rabasa-Lhoret
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002170:Canada; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000175:diagnosis; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D012129:Respiratory Function Tests / Q000379:methods; D013223:Statistics as Topic
chemical_list: D001786:Blood Glucose
keywords: CFRD; Cystic fibrosis; Indeterminate glucose tolerance; Oral glucose tolerance test; Pulmonary function