title: A new minor diketopiperazine from the sponge-derived fungus Simplicillium sp. YZ-11.
abstract: Chemical investigation of the cultures of a sponge-derived fungus Simplicillium sp. YZ-11 led to the isolation of a new minor diketopiperazine alkaloid cyclo-(2-hydroxy-Pro-Gly) (1) and a natural lactone (S)-dihydro-5-[(S)- hydroxyphenylmethyl]-2(3H)-furanone (2), together with five known ergostane-type sterols (3-7). Their structures were established based on extensive spectroscopic methods ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC and HMBC) and optical rotation analysis.
authors.affiliation: a Chemistry & Chemical Engineering College, Yantai University , Yantai 264005 , P.R. China.
authors.forename: Bing-Fei
authors.initials: BF
authors.lastname: Yan
authors.forename: Sheng-Tao
authors.initials: ST
authors.lastname: Fang
authors.forename: Wen-Zuo
authors.initials: WZ
authors.lastname: Li
authors.forename: Su-Jing
authors.initials: SJ
authors.lastname: Liu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Chuan-Hai
authors.initials: CH
authors.lastname: Xia
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D000818:Animals; D001203:Ascomycota / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology*; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000470:Alkaloids; D054659:Diketopiperazines; D007783:Lactones; D013261:Sterols
keywords: Simplicillium sp; cyclo-(2-hydroxy-Pro-Gly); diketopiperazine; marine sponge; sterols