title: Potential role of coenzyme Q10 in facilitating recovery from statin-induced rhabdomyolysis.
abstract: Rhabdomyolysis is a rare, but serious complication of statin therapy, and represents the most severe end of the spectrum of statin-induced myotoxicity. We report a case where coenzyme Q10 facilitated recovery from statin-induced rhabdomyolysis and acute renal failure, which had initially persisted despite statin cessation and haemodialysis. This observation is biologically plausible due to the recognised importance of coenzyme Q10 in mitochondrial bioenergetics within myocytes, and the fact that statins inhibit farnesyl pyrophosphate production, a biochemical step crucial for coenzyme Q10 synthesis. Coenzyme Q10 is generally well tolerated, and may potentially benefit patients with statin-induced rhabdomyolysis.
authors.affiliation: Department of Cardiology, St Vincent's Hospital, Darlinghurst, New South Wales, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales, Australia; Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
authors.forename: L W
authors.initials: LW
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Jabbour
authors.forename: C S
authors.initials: CS
authors.lastname: Hayward
authors.forename: T J
authors.initials: TJ
authors.lastname: Furlong
authors.forename: L
authors.initials: L
authors.lastname: Girgis
authors.forename: P S
authors.initials: PS
authors.lastname: Macdonald
authors.forename: A M
authors.initials: AM
authors.lastname: Keogh
mesh_terms: D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function / Q000187:drug effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; C024989:coenzyme Q10
keywords: coenzyme Q10; lipid; renal failure; rhabdomyolysis; statin