title: Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization.
abstract: Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.
authors.affiliation: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil.
authors.forename: Marta
authors.initials: M
authors.lastname: Imamura
authors.affiliation: University of São Paulo School of Medicine, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Ezquerro
authors.affiliation: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil ; São Paulo Adventist University Center, Estrada de Itapecerica, 5859 Jardim IAE, 05858-001 São Paulo, SP, Brazil.
authors.forename: Fábio
authors.initials: F
authors.lastname: Marcon Alfieri
authors.affiliation: Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil.
authors.forename: Lucy
authors.initials: L
authors.lastname: Vilas Boas
authors.affiliation: Tropical Hematology Laboratory, Institute of Tropical Medicine of São Paulo and Medical Research Laboratory, LIM 52, University of São Paulo, Avenida Dr. Arnaldo, 455 Cerqueira César, 01246903 São Paulo, SP, Brazil.
authors.forename: Tania Regina
authors.initials: TR
authors.lastname: Tozetto-Mendoza
authors.affiliation: Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Domingo de Soto 100, Vila Mariana, 04116-030 São Paulo, SP, Brazil.
authors.forename: Janini
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Hacettepe University Medical School, Hacettepe University Faculty of Medicine, Sıhhiye, 06100 Ankara, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Özçakar
authors.affiliation: Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Building D3, 9220 Aalborg E, Denmark.
authors.forename: Lars
authors.initials: L
authors.lastname: Arendt-Nielsen
authors.affiliation: Clinical Research Center, Institute of Physical Medicine and Rehabilitation, University of São Paulo School of Medicine, Rua Jandiatuba, 580 Vila Andrade, 05716-150 São Paulo, SP, Brazil.
authors.forename: Linamara
authors.identifier: 0000-0001-5275-0733
authors.initials: L
authors.lastname: Rizzo Battistella
references.citation: Arthritis Rheum. 2009 Dec 15;61(12):1677-85
references.pmid: 19950319
references.citation: Arthritis Rheum. 1997 Apr;40(4):723-7
references.pmid: 9125256
references.citation: Arch Gerontol Geriatr. 2011 May-Jun;52(3):322-6
references.pmid: 20627334
references.citation: Arthritis Rheum. 2009 Jul;60(7):2037-45
references.pmid: 19565477
references.citation: Curr Opin Rheumatol. 2005 Sep;17(5):624-8
references.pmid: 16093843
references.citation: Arthritis Rheum. 2012 Sep;64(9):2907-16
references.pmid: 22421811
references.citation: Clin Exp Rheumatol. 2002 Nov-Dec;20(6):753-60
references.pmid: 12508765
references.citation: Obes Res. 2003 Apr;11(4):525-31
references.pmid: 12690081
references.citation: J Clin Endocrinol Metab. 1997 Dec;82(12):4196-200
references.pmid: 9398739
references.citation: Rheumatology (Oxford). 2003 Jul;42(7):903-4
references.pmid: 12826709
references.citation: J Bodyw Mov Ther. 2008 Oct;12(4):371-84
references.pmid: 19083696
references.citation: J Appl Physiol (1985). 2005 Nov;99(5):1977-84
references.pmid: 16037403
references.citation: Arthritis Rheum. 2012 Oct;64(10 ):3313-23
references.pmid: 22576756
references.citation: J Gerontol B Psychol Sci Soc Sci. 1999 Nov;54(6):S339-48
references.pmid: 10625969
references.citation: Osteoarthritis Cartilage. 2012 Oct;20(10):1075-85
references.pmid: 22796624
references.citation: Clin J Pain. 2008 Jun;24(5):456-62
references.pmid: 18496311
references.citation: Osteoarthritis Cartilage. 2010 Apr;18(4):476-99
references.pmid: 20170770
references.citation: Arthritis Rheum. 2001 Jun;44(6):1237-47
references.pmid: 11407681
references.citation: Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H735-44
references.pmid: 19151248
references.citation: Anat Rec. 1948 Dec;102(4):409-37
references.pmid: 18102849
references.citation: Annu Rev Cell Biol. 1993;9:317-43
references.pmid: 8280464
references.citation: J Clin Invest. 1993 Apr;91(4):1351-7
references.pmid: 8473487
references.citation: Arthritis Rheum. 1986 Aug;29(8):1039-49
references.pmid: 3741515
references.citation: J Am Geriatr Soc. 2008 Apr;56(4):644-51
references.pmid: 18312558
references.citation: Pain. 2010 Jun;149(3):573-81
references.pmid: 20418016
references.citation: Mod Rheumatol. 2014 Jan;24(1):166-71
references.pmid: 24261774
references.citation: J Am Geriatr Soc. 2002 Dec;50(12):1947-54
references.pmid: 12473005
references.citation: Ann Biol Clin (Paris). 2001 May-Jun;59(3):298
references.pmid: 11397678
references.citation: Br J Rheumatol. 1996 Aug;35(8):761-6
references.pmid: 8761189
references.citation: Aging Dis. 2012 Feb;3(1):130-40
references.pmid: 22500274
references.citation: Clin Interv Aging. 2014 Jun 12;9:939-44
references.pmid: 24959074
references.citation: Arthritis Rheum. 2009 Dec;60(12):3546-53
references.pmid: 19950287
references.citation: Arthritis Res Ther. 2011 Feb 14;13(1):R22
references.pmid: 21320321
references.citation: Arch Phys Med Rehabil. 2008 Jan;89(1):16-23
references.pmid: 18164325
references.citation: Rheumatology (Oxford). 2001 Jul;40(7):743-9
references.pmid: 11477278
references.citation: Eur Cell Mater. 2011 Feb 24;21:202-20
references.pmid: 21351054
references.citation: Clin Microbiol Rev. 1997 Oct;10(4):742-80
references.pmid: 9336671
references.citation: Pain. 2012 Sep;153(9):1932-8
references.pmid: 22805779
references.citation: Arthritis Rheum. 2008 Oct 15;59(10):1424-31
references.pmid: 18821657
references.citation: Osteoarthritis Cartilage. 2009 Aug;17(8):1040-8
references.pmid: 19289234
references.citation: Arthritis Rheum. 2013 Feb;65(2):363-72
references.pmid: 22961435
references.citation: J Rheumatol. 1988 Dec;15(12):1833-40
references.pmid: 3068365
references.citation: Osteoarthritis Cartilage. 2010 Nov;18(11):1441-7
references.pmid: 20816981
references.citation: Osteoarthritis Cartilage. 2007 May;15(5):516-23
references.pmid: 17157039
references.citation: J Neuroimmunol. 2010 Mar 30;220(1-2):108-13
references.pmid: 20129677
references.citation: J Rheumatol. 2004 Oct;31(10):2027-31
references.pmid: 15468370
references.citation: Clin Biochem. 2011 Oct;44(14-15):1218-22
references.pmid: 21819974
references.citation: Longev Healthspan. 2013 May 02;2(1):8
references.pmid: 24472098
references.citation: Rheumatol Int. 2013 Apr;33(4):903-11
references.pmid: 22821260