title: Injury response checkpoint and developmental timing in insects.
abstract: In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.
authors.affiliation: a School of Mathematical and Natural Sciences; Arizona State University ; Phoenix , AZ USA ;
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Hackney
authors.forename: Peter
authors.initials: P
authors.lastname: Cherbas
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D007313:Insecta / Q000254:growth & development* / Q000502:physiology*; D007814:Larva
chemical_list: D019476:Insect Proteins
keywords: 20E 20-hydroxyecdysone; DILP8, Drosophila Insulin-Like Peptide 8; Developmental Timing; Drosophila Development; E, ecdysone; Ecdysone; Injury; PTTH; PTTH, prothoracicotropic hormone; Regeneration
references.citation: Annu Rev Pharmacol Toxicol. 1999;39:295-312
references.pmid: 10331086
references.citation: Cell. 1999 Jun 25;97(7):865-75
references.pmid: 10399915
references.citation: Development. 1999 Oct;126(20):4581-9
references.pmid: 10498692
references.citation: Cell. 1999 Sep 17;98(6):779-90
references.pmid: 10499795
references.citation: Genetics. 2000 Mar;154(3):1203-11
references.pmid: 10757764
references.citation: Biochem J. 2000 Jul 1;349(Pt 1):239-45
references.pmid: 10861234
references.citation: Dev Biol. 2000 Oct 1;226(1):1-17
references.pmid: 10993670
references.citation: Best Pract Res Clin Endocrinol Metab. 2002 Mar;16(1):73-90
references.pmid: 11987900
references.citation: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7438-43
references.pmid: 12032301
references.citation: Horm Res. 2002;57 Suppl 2:53-6
references.pmid: 12065928
references.citation: Evol Dev. 2003 Mar-Apr;5(2):188-97
references.pmid: 12622736
references.citation: BMC Dev Biol. 2003 Jul 5;3:5
references.pmid: 12844367
references.citation: Development. 1992 Dec;116(4):865-76
references.pmid: 1295740
references.citation: Aust J Biol Sci. 1954 Aug;7(3):302-7
references.pmid: 13219037
references.citation: Aust J Biol Sci. 1954 Nov;7(4):525-36
references.pmid: 13229848
references.citation: Radiat Res. 1956 Dec;5(6):657-73
references.pmid: 13379619
references.citation: Genetics. 2003 Dec;165(4):1869-79
references.pmid: 14704172
references.citation: Dev Biol. 2005 Apr 15;280(2):362-72
references.pmid: 15882578
references.citation: PLoS Biol. 2005 Sep;3(9):e289
references.pmid: 16086608
references.citation: Curr Biol. 2005 Oct 25;15(20):1796-807
references.pmid: 16182527
references.citation: Trop Med Int Health. 2005 Nov;10(11):1180-6
references.pmid: 16262744
references.citation: Proc Natl Acad Sci U S A. 1937 Sep;23(9):478-84
references.pmid: 16577798
references.citation: Int J Radiat Biol. 2006 Jun;82(6):435-41
references.pmid: 16846978
references.citation: Biochem Soc Trans. 2006 Dec;34(Pt 6):1256-60
references.pmid: 17073797
references.citation: Dev Cell. 2007 Dec;13(6):857-71
references.pmid: 18061567
references.citation: J Burn Care Res. 2008 May-Jun;29(3):531-40
references.pmid: 18388566
references.citation: Dev Biol. 2008 Sep 1;321(1):18-26
references.pmid: 18632097
references.citation: BMC Dev Biol. 2008 Aug 08;8:78
references.pmid: 18687152
references.citation: PLoS Biol. 2009 Apr 7;7(4):e1000079
references.pmid: 19355788
references.citation: Dev Cell. 2009 Jun;16(6):797-809
references.pmid: 19531351
references.citation: Mech Dev. 2010 May-Jun;127(5-6):308-19
references.pmid: 20093179
references.citation: Curr Biol. 2010 Mar 9;20(5):458-63
references.pmid: 20189388
references.citation: Biol Bull. 1947 Feb;92(1):1-9
references.pmid: 20284989
references.citation: J Exp Zool. 1946 Mar;101:261-80
references.pmid: 21022220
references.citation: Science. 2012 May 4;336(6081):579-82
references.pmid: 22556250
references.citation: Science. 2012 May 4;336(6081):582-5
references.pmid: 22556251
references.citation: Annu Rev Genet. 2012;46:289-310
references.pmid: 22934642
references.citation: Annu Rev Entomol. 2013;58:497-516
references.pmid: 23072462
references.citation: PLoS One. 2012;7(11):e49105
references.pmid: 23166607
references.citation: Dev Biol. 1989 Jul;134(1):222-35
references.pmid: 2471660
references.citation: Keio J Med. 1989 Sep;38(3):262-76
references.pmid: 2511373
references.citation: Wilehm Roux Arch Dev Biol. 1975 Sep;178(3):247-275
references.pmid: 28304775
references.citation: Wilhelm Roux Arch Entwickl Mech Org. 1974 Mar;176(1):23-65
references.pmid: 28304815
references.citation: Wilhelm Roux Arch Entwickl Mech Org. 1972 Mar;170(1):48-82
references.pmid: 28304831
references.citation: Wilehm Roux Arch Dev Biol. 1975 Jun;178(2):167-183
references.pmid: 28304934
references.citation: Wilhelm Roux Arch Entwickl Mech Org. 1973 Dec;172(4):349-354
references.pmid: 28305402
references.citation: Roux Arch Dev Biol. 1990 Apr;199(4):219-227
references.pmid: 28306107
references.citation: Wilhelm Roux Arch Entwickl Mech Org. 1959 Jan;151(3):323-380
references.pmid: 28354209
references.citation: Mol Cell Endocrinol. 1985 Jan;39(1):71-8
references.pmid: 2982678
references.citation: Mol Cell Endocrinol. 1986 Sep;47(1-2):25-33
references.pmid: 3017787
references.citation: Bioessays. 1988 May;8(5):153-7
references.pmid: 3044357
references.citation: Genetics. 1986 Feb;112(2):217-28
references.pmid: 3079719
references.citation: Dev Biol. 1977 Feb;55(2):213-32
references.pmid: 402295
references.citation: Dev Biol. 1973 Aug;33(2):441-56
references.pmid: 4207978
references.citation: Cold Spring Harb Symp Quant Biol. 1974;38:655-62
references.pmid: 4208797
references.citation: Dev Biol. 1974 Jul;39(1):141-57
references.pmid: 4209831
references.citation: J Exp Biol. 1974 Oct;61(2):493-501
references.pmid: 4443741
references.citation: Dev Biol. 1972 Jan;27(1):71-83
references.pmid: 4621757
references.citation: Dev Biol. 1971 Feb;24(2):233-63
references.pmid: 4994924
references.citation: Dev Biol. 1971 Dec;26(4):637-51
references.pmid: 5002603
references.citation: Proc Natl Acad Sci U S A. 1971 Oct;68(10):2594-8
references.pmid: 5002822
references.citation: Gen Comp Endocrinol. 1971 Dec;17(3):483-9
references.pmid: 5128300
references.citation: Biol Bull. 1970 Feb;138(1):47-55
references.pmid: 5437915
references.citation: Nature. 1969 Mar 8;221(5184):933-5
references.pmid: 5765504
references.citation: Endocrinol Exp. 1983 Mar;17(1):33-45
references.pmid: 6409583
references.citation: J Exp Biol. 1984 Jul;111:13-30
references.pmid: 6491588
references.citation: Gen Comp Endocrinol. 1984 Jun;54(3):469-77
references.pmid: 6735164
references.citation: J Embryol Exp Morphol. 1980 Jun;57:107-18
references.pmid: 6776221
references.citation: Proc Natl Acad Sci U S A. 1980 Jul;77(7):4175-9
references.pmid: 6776524
references.citation: Dev Biol. 1982 Sep;93(1):240-56
references.pmid: 6813163
references.citation: J Embryol Exp Morphol. 1980 Jun;57:155-65
references.pmid: 7430927
references.citation: Receptor. 1993 Fall;3(3):203-9
references.pmid: 8167571
references.citation: Biol Bull. 1977 Aug;153(1):145-62
references.pmid: 889943
references.citation: Genetics. 1998 May;149(1):217-31
references.pmid: 9584098
references.citation: Science. 1978 Jun 30;200(4349):1448-59
references.pmid: 96525
references.citation: Genes Dev. 1998 Dec 1;12(23):3741-51
references.pmid: 9851980