title: Dyslipidaemia in woman with polycystic ovarian syndrome: a case control study in tertiary care hospital of Karachi.
abstract: OBJECTIVE
  To compare lipid profile in lean and obese women with polycystic ovary syndrome with normal weight and obese controls.
  
  
  METHODS
  The case-control study was conducted at the Department of Chemical Pathology, Liaquat National Hospital, Karachi, from March 2006 to April 2007. It comprised 50 cases of polycystic ovary syndrome along with 50 healthy controls matching for age, gender and weight. SPSS 14 was used for statistical analysis.
  
  
  RESULTS
  The mean fasting levels of triglyceride and Low density lipoprotein cholesterol were considerably higher in women with polycystic ovary syndrome than those in the control group (p < 0.05), while high-density lipoprotein cholesterolwas significantly low in patients than the controls (p <0.001). Obese patients had high triglyceride value (p < 0.05). There was significant interaction between polycystic ovary syndrome, obesity and triglyceride levels (p < 0.05).
  
  
  CONCLUSIONS
  Polycystic ovary syndrome is associated with a more pronounced atherogenic lipid profile. Lipid parameters were adversely affected in a subgroup that was obese. As such, women with polycystic ovary syndrome are at high risk of developing cardiovascular disease due to the presence of dyslipidaemia.
authors.forename: Amna
authors.initials: A
authors.lastname: Hussain
authors.forename: Junaid Mahmood
authors.initials: JM
authors.lastname: Alam
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D009765:Obesity; D010154:Pakistan / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology*; D062606:Tertiary Care Centers; D055815:Young Adult