title: Development of floating chitosan-xanthan beads for oral controlled release of glipizide.
abstract: BACKGROUND
  The aim of the present work was to develop controlled release, floating and mucoadhesive beads of glipizide by using the polyionic complexation technique. Plasma half-life of glipizide being 2-4 h was selected for development of controlled release dosage form.
  
  
  METHODS
  Formulation batches were designed by employing chitosan as cationic and xanthan gum as anionic polymers. In vitro drug release was evaluated for the period of 24 h in phosphate buffer pH 7.4.
  
  
  RESULTS
  Sustained release of drug was observed in all formulation batches with % drug release ranging from 87.50% to 100.67%, no significant effect on the drug release was observed after varying chitosan to xanthan gum ratio. Encapsulation efficiency was found to be in the range of 79.48 ± 1.10-94.48 ± 1.52. In vitro bioadhesion studies showed that beads had satisfactory bioadhesive strength ranging from 67.11% ± 1.73% to 93.12% ± 1.56%. Buoyancy studies revealed that beads possess comparable floating capacity in the gastric fluids. Swelling kinetics was carried in pH 1.2 and 7.4 buffers. Significant difference (P < 0.05) in swelling kinetics was observed. Drug to polymer interaction was analyzed by Fourier transform infrared spectroscopy and differential scanning calorimetry studies. Scanning electron microscopy studies revealed that formed beads were discrete with rough and wrinkled surfaces.
  
  
  CONCLUSIONS
  In conclusion, beads were successfully formed by employing chitosan and xanthan gum and showed to possess sustained release effect. Beads also showed pH dependent swelling kinetics, this property can also be applied for the drugs which are susceptible to the acidic environment in the stomach, and comparable bioadhesive and floating properties were also observed.
authors.affiliation: Department of Pharmacutics, Smt. Kashibai Navale College of Pharmacy, Kondhwa-Saswad Road, Yeolewadi, Kondhwa (Bk.), Pune, Maharashtra, India.
authors.forename: Nilesh
authors.initials: N
authors.lastname: Kulkarni
authors.affiliation: Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Nagsenvan, Aurangabad, Maharashtra, India.
authors.forename: Pravin
authors.initials: P
authors.lastname: Wakte
authors.affiliation: Department of Chemical Technology, North Maharashtra University, Jalgaon, Maharashtra, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Naik
keywords: Beads; chitosan; polyelectrolyte complexation; sustained release; xanthan gum
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