title: The use of infrared thermography as a rapid, quantitative, and noninvasive method for evaluation of inflammation response in different anatomical regions of rats.
abstract: OBJECTIVE
  Thermographic assessment of temperature distribution within the examined tissues allows a quick, noncontact, noninvasive measurement of their temperature. The aim of the study was to evaluate the usefulness of digital infrared imaging in monitoring experimental inflammation of pleura (PL), lower lip (LL), and left paw (LP) and right paw (RP) of lower limbs in rats.
  
  
  METHODS
  The inflammatory reaction was induced by injection of 1% carrageenin solution into pleural cavity, lip, or paws. With the use of digital infrared imaging temperature measurement was conducted at 0 to 72 hours of the inflammatory reaction.
  
  
  RESULTS
  The temperature decrease was observed at the site of injection directly afterwards. Next, it was gradually increasing and it reached the maximum on the third day of the inflammatory reaction. Statistically significant changes were observed after 48-hour period in PL and LL regions, as well as after 72-hour period in LP and RP regions (P < 0.005).
  
  
  CONCLUSIONS
  It was found that thermographic examination allows for indicating the presence of inflammatory reaction within examined tissues and determining the dynamics of this process. This method could be used as alternative procedure that allows using fewer animals for experiments.
authors.affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618 Wroclaw, Poland.
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Całkosiński
authors.affiliation: Department of Conservative Dentistry and Pedodontics, The Faculty of Dentistry, Wroclaw Medical University, 26 Krakowska Street, 50-425 Wroclaw, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Dobrzyński
authors.affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618 Wroclaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rosińczuk
authors.affiliation: Institute of Machines Design and Operation, Technical University of Wrocław, 7/9 Łukasiewicza Street, 50-371 Wroclaw, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Dudek
authors.affiliation: Department of Animal Physiology and Biostructure, The Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 1/3 Kożuchowska Street, 51-631 Wroclaw, Poland.
authors.forename: Aleksander
authors.initials: A
authors.lastname: Chrószcz
authors.affiliation: Department of Conservative Dentistry and Pedodontics, The Faculty of Dentistry, Wroclaw Medical University, 26 Krakowska Street, 50-425 Wroclaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Fita
authors.affiliation: Department of Nervous System Diseases, The Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618 Wroclaw, Poland.
authors.forename: Robert
authors.identifier: 0000-0002-2806-1775
authors.initials: R
authors.lastname: Dymarek
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000379:methods*; D005121:Extremities / Q000000981:diagnostic imaging* / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000473:pathology; D007259:Infrared Rays; D008297:Male; D010994:Pleura / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D051381:Rats; D012881:Skin Temperature; D013817:Thermography
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