title: Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice.
abstract: OBJECTIVE
  It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder.
  
  
  METHODS
  The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques.
  
  
  RESULTS
  Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05).
  
  
  CONCLUSIONS
  The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Seheon
authors.initials: S
authors.lastname: Jung
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sun-Ouck
authors.initials: SO
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Kyung-Aa
authors.initials: KA
authors.lastname: Cho
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Seung Hee
authors.initials: SH
authors.lastname: Song
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Teak Won
authors.initials: TW
authors.lastname: Kang
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Kwangsung
authors.initials: K
authors.lastname: Park
authors.affiliation: Department of Urology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Dongdeuk
authors.initials: D
authors.lastname: Kwon
keywords: Aquaporin 1; Bladder; Caveolin 1
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