title: Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway.
abstract: There are few studies on the correlation between heme oxygenase-1 (HO-1) and acute myeloid leukemia (AML). We found that HO-1 was aberrantly overexpressed in the majority of AML patients, especially in patients with acute monocytic leukemia (M5) and leukocytosis, and inhibited the apoptosis of HL-60 and U937 cells. Moreover, silencing HO-1 prolonged the survival of xenograft mouse models. Further studies demonstrated that HO-1 suppressed the apoptosis of AML cells through activating the JNK/c-JUN signaling pathway. These data indicate a molecular role of HO-1 in inhibiting cell apoptosis, allowing it to be a potential target for treating AML.
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, the Affiliated Baiyun Hospital of Guiyang Medical College, Guiyang 550004, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Fang
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Shuya
authors.initials: S
authors.lastname: Chen
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Zhe
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Qixiang
authors.initials: Q
authors.lastname: Chai
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Meisheng
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Yaming
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China.
authors.forename: Ziming
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Guiyang Medical College, Guiyang 550004, China; Department of Hematology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; Guizhou Provincial Laboratory of Hematopoietic Stem Cell Transplantation Center, Guiyang 550004, China. Electronic address: wangjishi9646@163.com.
authors.forename: Jishi
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D015536:Down-Regulation; D005260:Female; D018922:HL-60 Cells; D051547:Heme Oxygenase-1 / Q000502:physiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008875:Middle Aged; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*; D020298:U937 Cells; D055815:Young Adult
chemical_list: D016755:Proto-Oncogene Proteins c-jun; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1
keywords: Acute myeloid leukemia; Apoptosis; Heme oxygenase-1; JNK/c-JUN; Signaling pathway