title: Lineage factors and differentiation states in lung cancer progression.
abstract: Lung cancer encompasses a heterogeneous group of malignancies. Here we discuss how the remarkable diversity of major lung cancer subtypes is manifested in their transforming cell of origin, oncogenic dependencies, phenotypic plasticity, metastatic competence and response to therapy. More specifically, we review the increasing evidence that links this biological heterogeneity to the deregulation of cell lineage-specific pathways and the transcription factors that ultimately control them. As determinants of pulmonary epithelial differentiation, these poorly characterized transcriptional networks may underlie the etiology and biological progression of distinct lung cancers, while providing insight into innovative therapeutic strategies.
authors.affiliation: Department of Pathology, Pathology and Cancer Center, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: W K C
authors.initials: WK
authors.lastname: Cheung
authors.affiliation: Department of Pathology, Pathology and Cancer Center, Yale University School of Medicine, New Haven, CT, USA.|Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: D X
authors.initials: DX
authors.lastname: Nguyen
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D018450:Disease Progression; D022781:Hepatocytes / Q000473:pathology / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
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