title: Novel ferrocene-based bifunctional amine-thioureas for asymmetric Michael addition of acetylacetone to nitroolefins.
abstract: An efficient method was developed to synthesize ferrocene-based bifunctional amine-thioureas bearing multiple hydrogen-bonding donors. Asymmetric Michael addition of acetylacetone to nitroolefins catalyzed by these novel bifunctional catalysts affords the Michael adducts in high yield and moderate to excellent enantioselectivities. Multiple hydrogen-bonds play an important role in accelerating the reaction.
authors.affiliation: Key Laboratory of Applied Surface and Colloid Chemistry, School of Chemistry and Chemical Engineering Shaanxi Normal University, Xi'an, Shaanxi 710062, P.R. China. ychai@snnu.edu.cn.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ren
authors.forename: Chunyan
authors.initials: C
authors.lastname: He
authors.forename: Yingle
authors.initials: Y
authors.lastname: Feng
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Chai
authors.forename: Wei
authors.initials: W
authors.lastname: Yao
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.forename: Shengyong
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D000075163:Metallocenes; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010422:Pentanones / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000588:Amines; D005296:Ferrous Compounds; D000075163:Metallocenes; D009574:Nitro Compounds; D010422:Pentanones; C008790:acetylacetone; D013890:Thiourea; C004998:ferrocene