title: The fate and tissue disposition of deoxynivalenol in broiler chickens.
abstract: To evaluate the fate of deoxynivalenol (DON) in broilers, DON was administered either intravenously or orally to broilers at a dose of 1 mg/kg BW. Concentrations of DON in plasma were measurable up to 4 hr and 2 hr after intravenous and oral administration, respectively. Following intravenous administration, the values for the elimination half-life, the volume of distribution and the clearance were 1.25 ± 0.25 hr, 7.55 ± 2.03 l/kg and 4.16 ± 0.42 l/hr/kg, respectively. The oral bioavailability was 15.46 ± 4.02%. DON was detectable in all tissues examined after oral administration. These results suggest that DON is able to penetrate into the various tissues in broilers, though poorly absorbed from their gastrointestinal tract.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
authors.forename: Sasithorn
authors.initials: S
authors.lastname: Pralatnet
authors.forename: Saranya
authors.initials: S
authors.lastname: Poapolathep
authors.forename: Kanjana
authors.initials: K
authors.lastname: Imsilp
authors.forename: Phanwimol
authors.initials: P
authors.lastname: Tanhan
authors.forename: Supaporn
authors.initials: S
authors.lastname: Isariyodom
authors.forename: Susumu
authors.initials: S
authors.lastname: Kumagai
authors.forename: Amnart
authors.initials: A
authors.lastname: Poapolathep
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002645:Chickens / Q000378:metabolism; D007275:Injections, Intravenous / Q000662:veterinary; D014018:Tissue Distribution; D066007:Toxicokinetics; D014255:Trichothecenes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D014255:Trichothecenes; C007262:deoxynivalenol
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