title: Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Turkish patients with systemic lupus erythematosus.
abstract: The LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus. We conducted this study to compare the efficiency of LupusQoL-TR (validated Turkish version of the LupusQoL questionnaire) with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Turkish patients with lupus. Both questionnaires were conducted at a single visit to the clinic. Disease activity was measured with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Associations between the LupusQoL-TR and SF-36 domains were examined while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman's correlation coefficients, and Students t test were performed to analyze the data. A total of 113 consecutive patients with lupus (F/M 108:5, mean age 40.6 ± 11.9 years, mean disease duration 8.5 ± 7.0 years) were included, and 69 % of these were active. The median SLEDAI score was 2 (0-24), the mean global LupusQoL-TR score was 60.9 ± 23.3, and the mean SF-36 score was 41.2 ± 9.0. There was a significant correlation between LupusQoL-TR and SF-36 mean scores (r = 0.83; p < 0.001). QoL assessed by LupusQoL-TR and SF-36 did not correlate with disease activity (r = -0.11; p = 0.244 and r = -0.03; p = 0.721, respectively). LupusQoL-TR and SF-36 questionnaires were beneficial instruments in evaluating HRQoL in Turkish lupus patients. However, LupusQoL-TR and SF-36 were not associated with SLEDAI scores, which suggested that QoL might be affected by other factors besides disease activity, especially in clinically inactive or mildly active patients.
authors.affiliation: Department of Rheumatology, School of Medicine, Marmara University, 34890, Pendik, Istanbul, Turkey. sibely113@mynet.com.
authors.forename: Sibel
authors.initials: S
authors.lastname: Yilmaz-Oner
authors.affiliation: Department of Family Medicine, School of Medicine, Istanbul Bilim University, Istanbul, Turkey.
authors.forename: Can
authors.initials: C
authors.lastname: Oner
authors.affiliation: School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Fatih Mert
authors.initials: FM
authors.lastname: Dogukan
authors.affiliation: School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Toklong Filam
authors.initials: TF
authors.lastname: Moses
authors.affiliation: School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Kubra
authors.initials: K
authors.lastname: Demir
authors.affiliation: School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Nazar
authors.initials: N
authors.lastname: Tekayev
authors.affiliation: Department of Rheumatology, School of Medicine, Marmara University, 34890, Pendik, Istanbul, Turkey.
authors.forename: Pamir
authors.initials: P
authors.lastname: Atagunduz
authors.affiliation: Department of Nephrology, School of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: Serhan
authors.initials: S
authors.lastname: Tuglular
authors.affiliation: Department of Rheumatology, School of Medicine, Marmara University, 34890, Pendik, Istanbul, Turkey.
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
mesh_terms: D000328:Adult; D005260:Female; D006304:Health Status; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014421:Turkey
keywords: LupusQoL-TR; Quality of life; SF-36; Systemic lupus erythematosus
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