title: Successful Pregnancy After Sacrectomy Combined With Chemotherapy and Radiation for Ewing Sarcoma: Case Report and Literature Review.
abstract: BACKGROUND
  Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival.
  
  
  METHODS
  We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section.
  
  
  CONCLUSIONS
  Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan. Electronic address: jkakogawa@marianna-u.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Kakogawa
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nako
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kawamura
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Mochiduki
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: Naohiro
authors.initials: N
authors.lastname: Kanayama
authors.affiliation: Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D002585:Cesarean Section; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000601:surgery; D011247:Pregnancy; D018714:Radiotherapy, Adjuvant; D012447:Sacrum / Q000601:surgery*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*
keywords: Ewing sarcoma; Fertility preservation; Pregnancy; Sacrectomy