title: Mean platelet volume in brucellosis: correlation between brucella standard serum agglutination test results, platelet count, and C-reactive protein.
abstract: BACKGROUND
  Brucellosis, a zoonotic infection, was most widely diagnosed by the Brucella standard serum agglutination test (SAT). No previous publication has demonstrated a correlation between the degree of Brucella SAT agglutination positivity and the severity of brucellosis infection.
  
  
  OBJECTIVE
  To contribute to the clarification of the relationship between patelets and brucellosis. It is also aimed at evaluating the usefulness of the SAT titer as a measure of brucellosis severity.
  
  
  METHODS
  We compared the control (n=60) and patients (n=96) groups in terms of mean platelet volume (MPV), C-reactive protein (CRP) and platelet values. Patients were grouped according to their degree of agglutination positivity titers and compared by means of CRP, MPV and platelet values. We also investigated the relationship among logarithmic values of MPV, platelet and CRP parameters for each group.
  
  
  RESULTS
  Although statistically meaningful difference was observed between control and patients group in terms of MPV and platelet value, there were no statistically significant differences observed among patients groups. The physiological negative correlation between MPV and platelet count was not encountered in group 2 and 3. Logarithmic values of CRP were not correlated with logarithmic values of MPV and platelet counts.
  
  
  CONCLUSIONS
  The MPV could be a new parameter to evaluate hematologic abnormalities in patients with brucellosis. The SAT titer was not a useful measure for evaluation of the severity of brucellosis.
authors.affiliation: Clinical Biochemistry, Ankara Numune Training and Research Hospital, 06100, Ankara, Turkey.
authors.forename: Dogan Halef
authors.initials: DH
authors.lastname: Okan
authors.affiliation: Department of Biostatistics and Medical Informatics, Erciyes University, Faculty of Medicine, 38039, Kayseri -Turkey.
authors.forename: Zararsiz
authors.initials: Z
authors.lastname: Gökmen
authors.affiliation: Clinical Microbiology, Ankara Numune Training and Research Hospital 06100, Ankara, Turkey.
authors.forename: Bayik
authors.initials: B
authors.lastname: Seyit
authors.affiliation: Clinical Biochemistry, Ankara Numune Training and Research Hospital, 06100, Ankara, Turkey.
authors.forename: Koca
authors.initials: K
authors.lastname: Yuksel
authors.affiliation: Clinical Biochemistry, Ankara Numune Training and Research Hospital, 06100, Ankara, Turkey.
authors.forename: Zungun
authors.initials: Z
authors.lastname: Cevdet
authors.affiliation: Clinical Biochemistry, Ankara Numune Training and Research Hospital, 06100, Ankara, Turkey.
authors.forename: Akbulut
authors.initials: A
authors.lastname: Deniz
mesh_terms: D000372:Agglutination Tests / Q000592:standards*; D016470:Bacteremia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D001799:Blood Sedimentation; D002002:Brucella / Q000302:isolation & purification*; D002006:Brucellosis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D011237:Predictive Value of Tests; D012016:Reference Values; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D002097:C-Reactive Protein
keywords: Brucella; CRP; agglutination; mean platelet volume; platelet count
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