title: QuEChERs Combined with Online Interference Trapping LC-MS/MS Method for the Simultaneous Determination of 20 Polyfluoroalkane Substances in Dietary Milk.
abstract: In this study, a highly sensitive and reliable method for the determination of 20 polyfluoroalkane substances (PFASs) in milk was established using the QuEChERS approach and an online interference trapping LC-MS/MS analysis. By a calibration with stable-isotope-labeled internal standards, we showed that the method displayed excellent linear dynamic ranges for 20 PFASs (correlation coefficients ≥0.997). The LOQs for the two types of PFASs, perfluorinated carboxylic acids (PFCAs) and perfluorinated sulfonic acids (PFSAs), were 0.010 and 0.050 μg/L, respectively. At the three spiking levels, the average recoveries for PFCAs ranged from 78.5 to 111% with the RSD (n = 6) within 1.20-13.1%, and those for PFSAs ranged from 72.8 to 105% with the RSD (n = 6) within 3.53-14.9%. By the developed method, 16 PFASs were found to be positive in 46 milk samples, and the levels for the PFASs with longer chains were significantly higher than those reported from other known regions.
authors.affiliation: †Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.|‡School of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Yu
authors.affiliation: †Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.|‡School of Food and Biological Engineering, Jimei University, Xiamen 361021, China.
authors.forename: Dunming
authors.initials: D
authors.lastname: Xu
authors.affiliation: §Agilent Technologies (China) Limited, Beijing 100102, China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Lu
authors.affiliation: §Agilent Technologies (China) Limited, Beijing 100102, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Zhou
authors.affiliation: ∥Chinese Academy of Inspection and Quarantine, Beijing 100123, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.affiliation: ⊥Shenzhen Academy of Inspection and Quarantine, Shenzhen 518000, China.
authors.forename: Zhenfeng
authors.initials: Z
authors.lastname: Yue
authors.affiliation: †Xiamen Entry-Exit Inspection and Quarantine Bureau, Xiamen 361026, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D001331:Automation / Q000379:methods; D002417:Cattle; D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005466:Fluorocarbons / Q000737:chemistry* / Q000302:isolation & purification*; D005506:Food Contamination / Q000032:analysis; D008892:Milk / Q000737:chemistry*; D015394:Molecular Structure; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D005466:Fluorocarbons
keywords: LC-MS/MS; QuEChERS; interference trapping; milk; polyfluoroalkane substances