title: Effect of magnesium sulphate on sugammadex reversal time for neuromuscular blockade: a randomised controlled study.
abstract: Magnesium potentiates neuromuscular blockade. Sugammadex reverses rocuronium-induced blockade. The aim of this study was to determine the effect of pre-treatment with magnesium sulphate on sugammadex reversal time for neuromuscular blockade. Seventy-three patients were randomly assigned to receive magnesium sulphate (40 mg.kg(-1) ) or saline intravenously. After anaesthetic induction, continuous train-of-four monitoring was performed and rocuronium was administered (0.6 mg.kg(-1) ). When a second twitch appeared, the patients received sugammadex (2 mg.kg(-1) ). The median (IQR [range]) reversal time of moderate neuromuscular blockade to a train-of-four ratio of 0.9 facilitated by sugammadex was 115 (93-177.5 [68-315]) s in the magnesium group and 120 (105-140 [70-298]) s in the saline group (p = 0.79). The median (IQR [range]) clinical duration was 45 (35.5-53 [22-102]) min in the magnesium group and 37 (31-43 [19-73]) min in the saline group (p = 0.031). Pre-treatment with magnesium did not significantly affect sugammadex reversal time of moderate neuromuscular blockade induced by rocuronium.
authors.affiliation: Department of Surgery, Anaesthesiology, Surgical Sciences Postgraduate Program, Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro), Rio de Janeiro, Brazil.|Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health, Rio de Janeiro, Brazil.
authors.forename: P A
authors.initials: PA
authors.lastname: Germano Filho
authors.affiliation: Department of General and Specialised Surgery, Anaesthesiology, Fluminense Federal University (Universidade Federal Fluminense), Niteroi, Brazil.
authors.forename: I L
authors.initials: IL
authors.lastname: Cavalcanti
authors.affiliation: Faculty of Medicine, Anaesthesiology, Surgical Sciences Postgraduate Program, Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro), Rio de Janeiro, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Barrucand
authors.affiliation: Department of Surgery, Anaesthesiology, Surgical Sciences Postgraduate Program, Federal University of Rio de Janeiro (Universidade Federal do Rio de Janeiro), Rio de Janeiro, Brazil.|Bonsucesso Federal Hospital (Hospital Federal de Bonsucesso)/Brazilian Ministry of Health, Rio de Janeiro, Brazil.
authors.forename: N
authors.initials: N
authors.lastname: Verçosa
mesh_terms: D000328:Adult; D000732:Androstanols / Q000037:antagonists & inhibitors*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors*; D011446:Prospective Studies; D000077123:Rocuronium; D012965:Sodium Chloride / Q000008:administration & dosage; D000077122:Sugammadex; D013997:Time Factors; D047408:gamma-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D047408:gamma-Cyclodextrins; D000077122:Sugammadex; D012965:Sodium Chloride; D008278:Magnesium Sulfate; D000077123:Rocuronium