title: Light-emitting diode-assisted narrow band imaging video endoscopy system in head and neck cancer.
abstract: OBJECTIVE
  To validate the effectiveness of a newly developed light-emitting diode (LED)-narrow band imaging (NBI) system for detecting early malignant tumors in the oral cavity.
  
  
  METHODS
  Six men (mean age, 51.5 years) with early oral mucosa lesions were screened using both the conventional white light and LED-NBI systems.
  
  
  RESULTS
  Small elevated or ulcerative lesions were found under the white light view, and typical scattered brown spots were identified after shifting to the LED-NBI view for all six patients. Histopathological examination confirmed squamous cell carcinoma. The clinical stage was early malignant lesions (T1), and the patients underwent wide excision for primary cancer. This is the pilot study documenting the utility of a new LED-NBI system as an adjunctive technique to detect early oral cancer using the diagnostic criterion of the presence of typical scattered brown spots in six high-risk patients.
  
  
  CONCLUSIONS
  Although large-scale screening programs should be established to further verify the accuracy of this technology, its lower power consumption, lower heat emission, and higher luminous efficiency appear promising for future clinical applications.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Hsin-Jen
authors.initials: HJ
authors.lastname: Chang
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Yen-Liang
authors.initials: YL
authors.lastname: Chang
authors.affiliation: Electronic and Optoelectronic Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
authors.forename: Tzuan-Ren
authors.initials: TR
authors.lastname: Jeng
authors.affiliation: Electronic and Optoelectronic Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
authors.forename: Chun-Te
authors.initials: CT
authors.lastname: Wu
authors.affiliation: Electronic and Optoelectronic Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Angot
authors.affiliation: Electronic and Optoelectronic Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan.
authors.forename: Chun-Hsing
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Cathay General Hospital, Taipei, Taiwan.
authors.forename: Pa-Chun
authors.initials: PC
authors.lastname: Wang
keywords: Endoscopy; Light-emitting diode; Mouth neoplasms; Narrow band imaging; Screening
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