title: Higher frequency of methicillin resistant bacteria in children with familial mediterranean fever.
abstract: OBJECTIVE
  To investigate resistant microorganisms in nasal mucosa of children with Familial Mediterranean Fever.
  
  
  METHODS
  The study was conducted from March to May 2013 at Mustafa Kemal University, Turkey, and comprised children with Familial Mediterranean Fever and healthy controls. All subjects had no history of antibiotic or local and/or systemic steroid use within the preceding 2 weeks. Nasal swab samples were obtained from all the subjects. Strain identification was done by using standard methods. SPSS 13 was used for statistical analysis.
  
  
  RESULTS
  Of the 151 subjects in the study, 73 (48.34%) were cases and 78 (51.65%) were controls. Among the cases, there were 26(35.6%) girls, while among the controls, there were 40(51.3%) girls (p=0.052). The mean age of the cases was 7.78 ± 3.34 years (range: 3-15 years), while it was 8.15 ± 2.71 years (range: 3-16) among the controls (p = 0.208). Methicillin-resistant coagulase-negative staphylococcus and methicillin-resistant staphylococcus aureus were isolated in both the groups. The growth rate of resistant bacteria was 63% (n = 46) in the cases, in the controls (p = 0.003; odds ratio [OR]: 2.7; 95% confidence interval [CI]: 1.4-5.2). Among the controls, history of hospitalisation increased the risk for the presence of resistant bacteria by 7.7 fold (OR: 7.7; 95% CI: 1.4-40.4).
  
  
  CONCLUSIONS
  Higher rates of resistant bacteria showed that they were at risk of comorbidities related to antibiotic resistance.
authors.forename: Erhan
authors.initials: E
authors.lastname: Yengil
authors.forename: Cengiz
authors.initials: C
authors.lastname: Cevik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Silfeler
authors.forename: Erkan
authors.initials: E
authors.lastname: Yula
authors.forename: Ibrahim Ahmet
authors.initials: IA
authors.lastname: Kurtoglu
authors.forename: Vefik
authors.initials: V
authors.lastname: Arica
authors.forename: Cahit
authors.initials: C
authors.lastname: Ozer
mesh_terms: D000293:Adolescent; D002353:Carrier State / Q000382:microbiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D010505:Familial Mediterranean Fever; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D009296:Nasal Cavity / Q000382:microbiology*