title: Clinical remission in patients with active psoriatic arthritis treated with adalimumab and correlations in joint and skin manifestations.
abstract: OBJECTIVE
  Adalimumab (ADA) was evaluated for its efficacy in patients with moderate to severely active psoriatic arthritis (PsA) and for the presence of correlations in disease change variables.
  
  
  METHODS
  Patients with inadequate response to standard PsA therapy were given 40 mg of ADA every other week for up to 12 weeks or 20 weeks. Outcome variables encompassed tender joint count (TJC), swollen joint count (SJC), physician's global assessment (PGA) of psoriasis, Health Assessment Questionnaire (HAQ), patient's global assessment (PtGA) of disease activity and pain, C-reactive protein, as well as composite measures of disease activity. Patients with inactive skin disease symptoms at baseline were excluded from the remission analyses.
  
  
  RESULTS
  Of 268 patients with active baseline joint and skin disease and data available at Week 12 following open-label ADA therapy, 73 achieved joint remission (27.2%, TJC ≤ 1 + SJC ≤ 1) and 144 achieved skin remission criteria (53.7%, PGA = clear/almost clear). Simultaneous joint and skin remission criteria were achieved in 16.0% and 24.8% of patients at weeks 12 and 20, respectively. In patients who did not achieve skin and/or joint remission, 12-week ADA treatment improved mean clinical and functional scores. Joint remission was more frequently associated with achieving clinically relevant outcomes including HAQ, PtGA disease activity, and PtGA pain compared to skin remission. No correlation between improvement in skin and joint disease was observed.
  
  
  CONCLUSIONS
  ADA was effective in achieving strict criteria for remission in joint or skin disease in many patients with active PsA within 12 weeks and sustained through 20 weeks. (NCT00235885).
authors.affiliation: From the Ghent University Hospital, Ghent, Belgium; University of California at San Diego, La Jolla, California; University of Washington, Swedish Medical Center, Seattle, Washington, USA; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.F. Van den Bosch, MD, PhD, Ghent University Hospital; A. Kavanaugh, MD, University of California at San Diego; M. Kron, PhD; H. Kupper, MD, AbbVie Deutschland GmbH & Co KG; P.J. Mease, MD, University of Washington, Swedish Medical Center.
authors.forename: Filip
authors.initials: F
authors.lastname: Van den Bosch
authors.affiliation: From the Ghent University Hospital, Ghent, Belgium; University of California at San Diego, La Jolla, California; University of Washington, Swedish Medical Center, Seattle, Washington, USA; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.F. Van den Bosch, MD, PhD, Ghent University Hospital; A. Kavanaugh, MD, University of California at San Diego; M. Kron, PhD; H. Kupper, MD, AbbVie Deutschland GmbH & Co KG; P.J. Mease, MD, University of Washington, Swedish Medical Center.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
authors.affiliation: From the Ghent University Hospital, Ghent, Belgium; University of California at San Diego, La Jolla, California; University of Washington, Swedish Medical Center, Seattle, Washington, USA; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.F. Van den Bosch, MD, PhD, Ghent University Hospital; A. Kavanaugh, MD, University of California at San Diego; M. Kron, PhD; H. Kupper, MD, AbbVie Deutschland GmbH & Co KG; P.J. Mease, MD, University of Washington, Swedish Medical Center.
authors.forename: Martina
authors.initials: M
authors.lastname: Kron
authors.affiliation: From the Ghent University Hospital, Ghent, Belgium; University of California at San Diego, La Jolla, California; University of Washington, Swedish Medical Center, Seattle, Washington, USA; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.F. Van den Bosch, MD, PhD, Ghent University Hospital; A. Kavanaugh, MD, University of California at San Diego; M. Kron, PhD; H. Kupper, MD, AbbVie Deutschland GmbH & Co KG; P.J. Mease, MD, University of Washington, Swedish Medical Center.
authors.forename: Hartmut
authors.initials: H
authors.lastname: Kupper
authors.affiliation: From the Ghent University Hospital, Ghent, Belgium; University of California at San Diego, La Jolla, California; University of Washington, Swedish Medical Center, Seattle, Washington, USA; AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.F. Van den Bosch, MD, PhD, Ghent University Hospital; A. Kavanaugh, MD, University of California at San Diego; M. Kron, PhD; H. Kupper, MD, AbbVie Deutschland GmbH & Co KG; P.J. Mease, MD, University of Washington, Swedish Medical Center. pmease@philipmease.com.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Mease
mesh_terms: D000068879:Adalimumab / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000188:drug therapy*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000068879:Adalimumab
keywords: ADALIMUMAB; MINIMAL DISEASE ACTIVITY; PSORIATIC ARTHRITIS; REMISSION INDUCTION