title: Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology.
abstract: In recent years, the exploitation of phenomena surrounding microfluidics has seen an increase in popularity, as researchers have found a way to use their unique properties to create superior design alternatives. One such application is representing the properties and functions of different organs on a microscale chip for the purpose of drug testing or tissue engineering. With the introduction of "organ-on-a-chip" systems, researchers have proposed various methods on various organ-on-a-chip systems to mimic their in vivo counterparts. In this article, a systematic approach is taken to review current technologies pertaining to organ-on-a-chip systems. Design processes with attention to the particular instruments, cells, and materials used are presented.
authors.affiliation: Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Caplin
authors.affiliation: Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
authors.forename: Norma G
authors.initials: NG
authors.lastname: Granados
authors.affiliation: Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.
authors.forename: Myra R
authors.initials: MR
authors.lastname: James
authors.affiliation: Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.|Center for Advanced Host Defense Immunobiotics and Translational Comparative Medicine, Iowa State University, Ames, IA, 50011, USA.
authors.forename: Reza
authors.initials: R
authors.lastname: Montazami
authors.affiliation: Department of Mechanical Engineering, Iowa State University, Ames, IA, 50011, USA.|Center for Advanced Host Defense Immunobiotics and Translational Comparative Medicine, Iowa State University, Ames, IA, 50011, USA.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Hashemi
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry; D055808:Drug Discovery; D005472:Fluorouracil / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D005472:Fluorouracil
keywords: drug development; microfluidics; organ-on-a-chip technology; toxicology