title: [The characteristic of immunity in long-lived persons and selection of the immunosenescence markers].
abstract: Purpose of the work is to select the indices of immunograms, associated with immunosenescence. The lymphocyte subpopulations were defined by the method of polychrome flowing cytometry in 276 patients of 90+ year with the identical spectrum of chronic unspecific inflammatory diseases. The cluster was revealed consisting of subpopulation of T-lymphocytes (T-lymph) with the high frequency of deviations from standard--helper CD4+, cytotoxic CD8+--T-lymph. The activation of immunity was confirmed by the expression of HLA-DR molecule in 100% of persons with an increase of the absolute number CD4+ and/or CD8+. Reduction in the CD8+ and/or CD4+ was associated with the immune deficient state and the frequency of the increased actTcontent within limits of 63-83%. In 36 long-livers a quantity CD4+ and CD8+ corresponded to standard, 33 of them demonstrated actT exceeded standard. These patients were carried to the group of activation also. Basic group had the quantity CD8+ deficit (73%). In this group, frequency of the development of neuro-degenerate distributions and pathologic changes in the osteomuscular tissue were reliably higher in the persons at the age of 92 years and older than in persons younger 92 years. We consider that CD8+ deficit at the age older 90 year is biomarker of immunosenescence and the risk of an increase in the frequency of development of chronic unspecific inflammatory diseases.
authors.forename: I V
authors.initials: IV
authors.lastname: Miroshnichenko
authors.forename: V N
authors.initials: VN
authors.lastname: Stolpnikova
authors.forename: T V
authors.initials: TV
authors.lastname: Levashova
authors.forename: E A
authors.initials: EA
authors.lastname: Sorokina
authors.forename: S G
authors.initials: SG
authors.lastname: Toporova
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000276:immunology* / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008136:Longevity / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D018655:Lymphocyte Count; D015166:Monitoring, Immunologic; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens; D007136:Immunoglobulins