title: Alteration of laboratory findings after radiofrequency ablation of hepatocellular carcinoma: relationship to severity of the underlying liver disease and the ablation volume.
abstract: OBJECTIVE
  To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease.
  
  
  METHODS
  This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2-3 days, and 1-2 weeks after RFA. We classified the subjects into two groups: Child-Pugh A (n=41) and Child-Pugh B (n=24). The ablative margin volume (AMV) of each patient was measured. We analyzed the changes in laboratory profiles from the baseline, and investigated whether these laboratory changes were correlated with the AMV and the Child-Pugh classification.
  
  
  RESULTS
  Most of the laboratory values peaked at 2-3 days after RFA. AMV was significantly correlated with changes in WBC count, hemoglobin level, and serum total bilirubin level (Pearson's correlation coefficient, 0.324-0.453; P<0.05). The alanine aminotransferase (ALT) level varied significantly over time (P=0.023).
  
  
  CONCLUSIONS
  Most of the measured laboratory markers changed from baseline, peaking at 2-3 days. The ALT level was the only parameter for which there was a significant difference after RFA between Child-Pugh A and B patients: it increased significantly more in the Child-Pugh A patients.
authors.affiliation: Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Shin
authors.affiliation: Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. ; Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea.
authors.forename: Woo Kyoung
authors.initials: WK
authors.lastname: Jeong
authors.affiliation: Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
authors.forename: Sanghyeok
authors.initials: S
authors.lastname: Lim
authors.affiliation: Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea.
authors.forename: Yongsoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Radiology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea. ; Department of Radiology, Ajou University Hospital, Ajou University College of Medicine, Suwon, Korea.
authors.forename: Jinoo
authors.initials: J
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D015415:Biomarkers / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase; D001663:Bilirubin
keywords: Alanine aminotransferase; Child-Pugh class; Hepatocellular carcinoma; Leukocytosis; Radiofrequency ablation
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