title: Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with Trypanosoma evansi.
abstract: Trypanosoma evansi causes wasting disease in many livestock. T. evansi infection gives rise to inflammatory immune responses, which contribute to the development of inflammation-associated tissue injury. We previously reported that regulatory dendritic cells (DCs), which act as potential regulators of inflammation, were activated in infected mice and transfer of regulatory DCs to infected mice prolonged their survival. However, the kinetics of regulatory DCs in cattle, which are natural hosts of T. evansi, remained unclear. In this study, we report that the expressions of CCL8 and IL-10, which promote the development of regulatory DCs, were up-regulated in cattle experimentally infected with T. evansi. This finding is potentially useful for studying the control strategy of T. evansi infection in cattle.
authors.affiliation: Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060-0818, Japan.
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Mekata
authors.forename: Shiro
authors.initials: S
authors.lastname: Murata
authors.forename: Claro Niegos
authors.initials: CN
authors.lastname: Mingala
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ohashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Konnai
mesh_terms: D000818:Animals; D002417:Cattle / Q000276:immunology / Q000469:parasitology; D054412:Chemokine CCL8 / Q000097:blood / Q000502:physiology; D016207:Cytokines / Q000097:blood / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology*; D016753:Interleukin-10 / Q000097:blood / Q000502:physiology; D008297:Male; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D014345:Trypanosoma / Q000276:immunology*; D014354:Trypanosomiasis, Bovine / Q000276:immunology* / Q000469:parasitology
chemical_list: D054412:Chemokine CCL8; D016207:Cytokines; D016753:Interleukin-10
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