title: Models for predicting the adult height and age at first menstruation of girls with idiopathic central precocious puberty.
abstract: BACKGROUND
  It is difficult to determine whether to treat a given girl who has idiopathic central precocious puberty (CPP) with gonadotropin-releasing hormone analog (GnRHa) in terms of adult height (AH). The objective was to provide an easy tool for predicting AH and age at first menstruation at initial evaluation to help guide the decision regarding whether to treat.
  
  
  METHODS
  Data analysis using multiple linear regression models was performed in 134 girls with CPP. Among them 78 were given GnRHa because of low predicted AH (n=45), pubertal luteinising hormone (LH)/follicle-stimulating hormone peaks (FSH) ratio (n=50) and/or high plasma estradiol concentration (n=45). 56 girls were followed without treatment.
  
  
  RESULTS
  In the whole population, the actual AH (162.1±5.61 cm) was similar to target height (161.7±4.91 cm) and to AH predicted by the Bayley and Pinneau method (161.9±7.98 cm). Separated models for treated and untreated girls provide very close estimations, leading to a unique formula for both groups. The AH (cm) could be calculated at the initial evaluation: 2.21 (height at initial evaluation, SD) + 2.32 (target height, SD) - 1.83 (LH/FSH peaks ratio) + 159.68. The actual AH was lower than the calculated AH by more than 1 SD (5.6 cm) in 11 girls (8.0%). The time between onset of puberty and first menstruation (in untreated girls) can be estimated with: 10.9 - 0.57 (LH/FSH peaks ratio). The formulae are available at http://www.kamick.org/lemaire/med/girls-cpp15.html.
  
  
  CONCLUSIONS
  We established formulae that can be used at an initial evaluation to predict the AH, and the time between onset of puberty and first menstruation after spontaneous puberty. The similarity of the formulae for both groups suggests that the treatment had no significant effect on the AH. However, the criteria used to select treatment suggest that it prevents the deterioration of AH in cases with rapidly evolving form of CPP.
authors.affiliation: Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
authors.forename: Eloïse
authors.initials: E
authors.lastname: Giabicani
authors.affiliation: Université Grenoble Alpes and CNRS, G-SCOP, F-38000 Grenoble, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lemaire
authors.affiliation: Université Paris Descartes and Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
authors.forename: Raja
authors.initials: R
authors.lastname: Brauner
mesh_terms: D000367:Age Factors; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007986:Luteinizing Hormone; D008572:Menarche; D015233:Models, Statistical; D011629:Puberty, Precocious / Q000175:diagnosis*; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
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