title: Effect of addition of statins to antiviral therapy in hepatitis C virus-infected persons: Results from ERCHIVES.
abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been variably noted to affect hepatitis C virus (HCV) treatment response, fibrosis progression, and hepatocellular carcinoma (HCC) incidence, with some having a more potent effect than others. We sought to determine the impact of adding statins to antiviral therapy upon sustained virological response (SVR) rates, fibrosis progression, and HCC development among HCV-infected persons using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES), an established, longitudinal, national cohort of HCV-infected veterans. Within ERCHIVES, we identified those who received HCV treatment and a follow-up of >24 months after treatment completion. We excluded those with human immunodeficiency virus coinfection, hepatitis B surface antigen positivity, cirrhosis, and HCC at baseline. Our main outcomes were liver fibrosis progression measured by FIB-4 scores, SVR rates, and incident HCC (iHCC). Among 7,248 eligible subjects, 46% received statin therapy. Statin use was significantly associated with attaining SVR (39.2% vs. 33.3%; P < 0.01), decreased cirrhosis development (17.3% vs. 25.2%; P < 0.001), and decreased iHCC (1.2% vs. 2.6%; P < 0.01). Statins remained significantly associated with increased odds of SVR (odds ratio = 1.44; 95% confidence interval [CI] = 1.29, 1.61), but lower fibrosis progression rate, lower risk of progression to cirrhosis (hazard ratio [HR] = 0.56; 95% CI = -0.50, 0.63), and of incident HCC (HR = 0.51; 95% CI = 0.34, 0.76) after adjusting for other relevant clinical factors.
  
  
  CONCLUSIONS
  Statin use was associated with improved virological response (VR) rates to antiviral therapy and decreased progression of liver fibrosis and incidence of HCC among a large cohort of HCV-positive Veterans. These data support the use of statins in patients with HCV.
authors.affiliation: VA Pittsburgh Healthcare System, Pittsburgh, PA.|University of Pittsburgh School of Medicine, Pittsburgh, PA.|Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Adeel A
authors.initials: AA
authors.lastname: Butt
authors.affiliation: VA Pittsburgh Healthcare System, Pittsburgh, PA.
authors.forename: Peng
authors.initials: P
authors.lastname: Yan
authors.affiliation: ImmunoScience Inc., Pleasanton, CA.
authors.forename: Hector
authors.initials: H
authors.lastname: Bonilla
authors.affiliation: Hamad Healthcare Quality Institute, Hamad Medical Corporation, Doha, Qatar.
authors.forename: Abdul-Badi
authors.initials: AB
authors.lastname: Abou-Samra
authors.affiliation: VA Pittsburgh Healthcare System, Pittsburgh, PA.|University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors.forename: Obaid S
authors.initials: OS
authors.lastname: Shaikh
authors.affiliation: Brigham and Women's Hospital, Boston, MA.
authors.forename: Tracey G
authors.initials: TG
authors.lastname: Simon
authors.affiliation: Massachusetts General Hospital, Boston, MA.|Harvard Medical School, Boston, MA.
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Chung
authors.affiliation: VA Pittsburgh Healthcare System, Pittsburgh, PA.|University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors.forename: Shari S
authors.initials: SS
authors.lastname: Rogal
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000517:prevention & control / Q000821:virology; D015331:Cohort Studies; D016001:Confidence Intervals; D016208:Databases, Factual; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000401:mortality / Q000517:prevention & control* / Q000821:virology; D008113:Liver Neoplasms / Q000401:mortality / Q000517:prevention & control* / Q000821:virology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States; D014728:Veterans / Q000706:statistics & numerical data; D019562:Viral Load / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors