title: Lung transplantation for cystic fibrosis: results, indications, complications, and controversies.
abstract: Survival in patients with cystic fibrosis (CF) has improved dramatically over the past 30 to 40 years, with mean survival now approximately 40 years. Nonetheless, progressive respiratory insufficiency remains the major cause of mortality in CF patients, and lung transplantation (LT) is eventually required. Timing of listing for LT is critical, because up to 25 to 41% of CF patients have died while awaiting LT. Globally, approximately 16.4% of lung transplants are performed in adults with CF. Survival rates for LT recipients with CF are superior to other indications, yet LT is associated with substantial morbidity and mortality (∼50% at 5-year survival rates). Myriad complications of LT include allograft failure (acute or chronic), opportunistic infections, and complications of chronic immunosuppressive medications (including malignancy). Determining which patients are candidates for LT is difficult, and survival benefit remains uncertain. In this review, we discuss when LT should be considered, criteria for identifying candidates, contraindications to LT, results post-LT, and specific complications that may be associated with LT. Infectious complications that may complicate CF (particularly Burkholderia cepacia spp., opportunistic fungi, and nontuberculous mycobacteria) are discussed.
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Clinical Immunology and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Lynch
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Clinical Immunology and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: David M
authors.initials: DM
authors.lastname: Sayah
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Clinical Immunology and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: John A
authors.initials: JA
authors.lastname: Belperio
authors.affiliation: Division of Pulmonary, Critical Care Medicine, Clinical Immunology and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California.
authors.forename: S Sam
authors.initials: SS
authors.lastname: Weigt
mesh_terms: D003550:Cystic Fibrosis / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D016040:Lung Transplantation; D011183:Postoperative Complications / Q000175:diagnosis*
references.citation: Thorax. 2004 Jan;59(1):79-80
references.pmid: 14694255
references.citation: J Heart Lung Transplant. 2002 Feb;21(2):217-25
references.pmid: 11834350
references.citation: Am J Infect Control. 2003 May;31(3 Suppl):S1-62
references.pmid: 12762292
references.citation: Transplant Proc. 1997 Feb-Mar;29(1-2):627-8
references.pmid: 9123449
references.citation: J Thorac Cardiovasc Surg. 1998 Feb;115(2):404-13; discussion 413-4
references.pmid: 9475536
references.citation: Transplant Proc. 2013 Apr;45(3):1137-41
references.pmid: 23622646
references.citation: Am J Transplant. 2009 Sep;9(9):2085-91
references.pmid: 19645709
references.citation: J Heart Lung Transplant. 2006 Aug;25(8):985-8
references.pmid: 16890122
references.citation: Thorax. 2003 Sep;58(9):794-6
references.pmid: 12947141
references.citation: J Transplant. 2012;2012:135738
references.pmid: 22848792
references.citation: Eur Respir J. 1996 Jan;9(1):169-71
references.pmid: 8834350
references.citation: N Engl J Med. 2007 Jan 25;356(4):335-47
references.pmid: 17251530
references.citation: J Heart Lung Transplant. 1996 Mar;15(3):249-54
references.pmid: 8777207
references.citation: Am J Respir Crit Care Med. 2005 May 1;171(9):1053-9
references.pmid: 15695493
references.citation: Med J Aust. 2011 Oct 3;195(7):392-5
references.pmid: 21978346
references.citation: J Heart Lung Transplant. 2010 May;29(5):523-30
references.pmid: 20061165
references.citation: Dermatol Surg. 2012 Aug;38(8):1369-74
references.pmid: 22551390
references.citation: J Natl Cancer Inst. 2003 Mar 5;95(5):381-7
references.pmid: 12618503
references.citation: Transplant Proc. 2004 Apr;36(3):648-50
references.pmid: 15110621
references.citation: Semin Respir Crit Care Med. 2013 Feb;34(1):87-94
references.pmid: 23460008
references.citation: Am J Transplant. 2013 Apr;13(4):919-27
references.pmid: 23398785
references.citation: J Thorac Dis. 2014 Aug;6(8):1024-31
references.pmid: 25132969
references.citation: Am J Respir Crit Care Med. 2001 Feb;163(2):335-8
references.pmid: 11179102
references.citation: J Cyst Fibros. 2014 May;13(3):296-305
references.pmid: 24176390
references.citation: J Infect. 2012 Nov;65(5):453-64
references.pmid: 22898389
references.citation: Lancet Respir Med. 2014 Jan;2(1):73-82
references.pmid: 24461904
references.citation: Semin Respir Crit Care Med. 2011 Dec;32(6):717-26
references.pmid: 22167399
references.citation: Eur J Cardiothorac Surg. 2013 Jun;43(6):1220-5
references.pmid: 23091227
references.citation: Clin Infect Dis. 2008 Feb 1;46(3):327-60
references.pmid: 18177225
references.citation: Semin Respir Crit Care Med. 2013 Jun;34(3):380-404
references.pmid: 23821512
references.citation: J Cyst Fibros. 2013 Dec;12(6):729-36
references.pmid: 23478131
references.citation: J Heart Lung Transplant. 2009 Nov;28(11):1226-30
references.pmid: 19782585
references.citation: Curr Opin Pulm Med. 2006 Nov;12(6):459-63
references.pmid: 17053498
references.citation: Med Mycol. 2010 Nov;48 Suppl 1:S32-6
references.pmid: 21067327
references.citation: Transplantation. 2007 May 27;83(10):1330-6
references.pmid: 17519782
references.citation: Chest. 2009 Dec;136(6):1554-60
references.pmid: 19505987
references.citation: Prog Transplant. 2004 Dec;14(4):331-6
references.pmid: 15663018
references.citation: J Thorac Cardiovasc Surg. 2013 Apr;145(4):1065-70; discussion 1070-1
references.pmid: 23332185
references.citation: Thorax. 2004 Nov;59(11):948-51
references.pmid: 15516469
references.citation: Pediatr Pulmonol. 2010 Aug;45(8):764-71
references.pmid: 20597074
references.citation: J Heart Lung Transplant. 2001 Mar;20(3):288-96
references.pmid: 11257554
references.citation: Clin Gastroenterol Hepatol. 2013 Apr;11(4):333-42; quiz e30-1
references.pmid: 23142604
references.citation: J Clin Microbiol. 2010 May;48(5):1978-82
references.pmid: 20220160
references.citation: Transpl Infect Dis. 2010 Jun;12(3):220-9
references.pmid: 20113459
references.citation: Lancet. 1994 Aug 20;344(8921):552-3
references.pmid: 7520109
references.citation: Eur Radiol. 2004 Mar;14 Suppl 3:E34-42
references.pmid: 14749960
references.citation: Curr Opin Pulm Med. 2013 Nov;19(6):676-80
references.pmid: 24060981
references.citation: J Clin Microbiol. 2009 Dec;47(12):4124-8
references.pmid: 19846643
references.citation: ANZ J Surg. 2014 Oct;84(10):740-4
references.pmid: 24237857
references.citation: Am J Gastroenterol. 1996 Nov;91(11):2382-90
references.pmid: 8931422
references.citation: Transpl Infect Dis. 2009 Jun;11(3):243-8
references.pmid: 19298240
references.citation: Ann Thorac Surg. 1989 Nov;48(5):744-5
references.pmid: 2818077
references.citation: JAMA. 2005 Feb 2;293(5):581-8
references.pmid: 15687313
references.citation: J Hosp Infect. 2004 Apr;56(4):277-82
references.pmid: 15066737
references.citation: J Cyst Fibros. 2014 Mar;13(2):212-8
references.pmid: 24041590
references.citation: Clin Infect Dis. 1998 Mar;26(3):753-5
references.pmid: 9524855
references.citation: Clin Infect Dis. 2005 Feb 15;40(4):581-7
references.pmid: 15712081
references.citation: J Cyst Fibros. 2015 Jan;14(1):104-10
references.pmid: 24948447
references.citation: Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1206-12
references.pmid: 10764313
references.citation: Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1892-9
references.pmid: 9620924
references.citation: Best Pract Res Clin Gastroenterol. 2010 Oct;24(5):585-92
references.pmid: 20955961
references.citation: Paediatr Respir Rev. 2013 May;14 Suppl 1:26-7
references.pmid: 23601208
references.citation: Chest. 2002 Oct;122(4):1185-91
references.pmid: 12377840
references.citation: Am J Infect Control. 2000 Oct;28(5):381-5
references.pmid: 11029140
references.citation: Ann Thorac Surg. 1994 Jun;57(6):1423-7; discussion 1428
references.pmid: 8010783
references.citation: J Cyst Fibros. 2010 Jul;9(4):272-6
references.pmid: 20400381
references.citation: J Heart Lung Transplant. 2008 Jul;27(7):729-34
references.pmid: 18582801
references.citation: J Heart Lung Transplant. 2008 Jan;27(1):60-5
references.pmid: 18187088
references.citation: J Heart Lung Transplant. 2006 May;25(5):603-7
references.pmid: 16678041
references.citation: Chest. 2000 Jul;118(1):115-22
references.pmid: 10893368
references.citation: Emerg Infect Dis. 2008 Mar;14(3):378-84
references.pmid: 18325250
references.citation: J Heart Lung Transplant. 2005 Jul;24(7):865-9
references.pmid: 15982615
references.citation: J Appl Microbiol. 2008 Jun;104(6):1539-51
references.pmid: 18217926
references.citation: Pediatr Transplant. 2014 Jun;18(4):393-7
references.pmid: 24802346
references.citation: Transplant Proc. 2014 Jul-Aug;46(6):1849-51
references.pmid: 25131052
references.citation: Transplant Proc. 2011 May;43(4):1162-3
references.pmid: 21620078
references.citation: J Artif Organs. 2013 Sep;16(3):382-5
references.pmid: 23508264
references.citation: Transplantation. 2003 Aug 27;76(4):683-8
references.pmid: 12973109
references.citation: Cochrane Database Syst Rev. 2014;3:CD002010
references.pmid: 24627308
references.citation: J Clin Microbiol. 2001 Feb;39(2):816-9
references.pmid: 11158161
references.citation: J Heart Lung Transplant. 2006 Oct;25(10):1268-72
references.pmid: 17045941
references.citation: Transplantation. 2012 Aug 15;94(3):281-6
references.pmid: 22790447
references.citation: Am J Respir Crit Care Med. 2013 Jun 15;187(12):1335-40
references.pmid: 23590274
references.citation: Pediatr Pulmonol. 2009 Nov;44(11):1100-6
references.pmid: 19830845
references.citation: Semin Respir Crit Care Med. 2009 Oct;30(5):539-46
references.pmid: 19760541
references.citation: Chest. 2004 Aug;126(2):412-9
references.pmid: 15302726
references.citation: J Thorac Cardiovasc Surg. 2004 Jan;127(1):114-22
references.pmid: 14752421
references.citation: Clin Infect Dis. 2000 Mar;30(3):603-5
references.pmid: 10722455
references.citation: Proc Am Thorac Soc. 2010 May;7(3):210-5
references.pmid: 20463250
references.citation: Antimicrob Agents Chemother. 2012 May;56(5):2371-7
references.pmid: 22330924
references.citation: J Cyst Fibros. 2012 Jan;11(1):40-5
references.pmid: 22035707
references.citation: BMJ Case Rep. 2009;2009:null
references.pmid: 21686410
references.citation: J Cyst Fibros. 2012 Mar;11(2):131-6
references.pmid: 22112935
references.citation: Pediatr Pulmonol. 2004 May;37(5):419-26
references.pmid: 15095325
references.citation: Antimicrob Agents Chemother. 1993 Jan;37(1):123-5
references.pmid: 8431009
references.citation: Thorax. 2009 Jun;64(6):535-40
references.pmid: 19282318
references.citation: J Infect Chemother. 2003 Dec;9(4):328-32
references.pmid: 14691654
references.citation: J Cyst Fibros. 2013 Sep;12 Suppl 2:S1-20
references.pmid: 24064077
references.citation: Paediatr Respir Rev. 2013 May;14 Suppl 1:6-9
references.pmid: 23497942
references.citation: Transplant Proc. 2013 Sep;45(7):2621-3
references.pmid: 24034007
references.citation: Semin Respir Crit Care Med. 2011 Dec;32(6):673-81
references.pmid: 22167395
references.citation: J R Soc Med. 2008 Jul;101 Suppl 1:S31-5
references.pmid: 18607016
references.citation: Int J Antimicrob Agents. 2009 May;33(5):394-404
references.pmid: 19097867
references.citation: Ann Thorac Surg. 1995 Jul;60(1):139-43
references.pmid: 7598576
references.citation: J Heart Lung Transplant. 2007 Jan;26(1):41-7
references.pmid: 17234516
references.citation: J Heart Lung Transplant. 2008 Jan;27(1):11-6
references.pmid: 18187081
references.citation: Pediatr Transplant. 2013 Dec;17(8):E182-8
references.pmid: 24164831
references.citation: J Cyst Fibros. 2008 Sep;7(5):368-72
references.pmid: 18276200
references.citation: Am J Transplant. 2009 Aug;9(8):1903-11
references.pmid: 19459819
references.citation: J Heart Lung Transplant. 1998 Oct;17(10):1029-33
references.pmid: 9811413
references.citation: Ther Drug Monit. 2003 Feb;25(1):28-35
references.pmid: 12548141
references.citation: Semin Respir Crit Care Med. 2013 Feb;34(1):124-34
references.pmid: 23460012
references.citation: Hepat Mon. 2013 Aug 14;13(8):e11215
references.pmid: 24171010
references.citation: Chest. 2003 Jun;123(6):1832-7
references.pmid: 12796157
references.citation: Arch Bronconeumol. 2013 Jun;49(6):272-4
references.pmid: 23427867
references.citation: Transplant Rev (Orlando). 2008 Apr;22(2):89-104
references.pmid: 18631862
references.citation: Clin Infect Dis. 2001 Jun 1;32(11):1648-50
references.pmid: 11340540
references.citation: Am J Respir Crit Care Med. 2006 Mar 15;173(6):659-66
references.pmid: 16387803
references.citation: Transpl Infect Dis. 2006 Dec;8(4):213-8
references.pmid: 17116134
references.citation: J Antimicrob Chemother. 2009 Dec;64(6):1274-81
references.pmid: 19841031
references.citation: Chest. 2006 Jul;130(1):222-6
references.pmid: 16840406
references.citation: Lancet. 2013 May 4;381(9877):1551-60
references.pmid: 23541540
references.citation: Eur Respir J. 2007 Mar;29(3):522-6
references.pmid: 17182652
references.citation: J Heart Lung Transplant. 2007 Aug;26(8):834-8
references.pmid: 17692788
references.citation: Lancet. 2005 Aug 6-12;366(9484):463-71
references.pmid: 16084254
references.citation: Medicine (Baltimore). 1999 Mar;78(2):123-38
references.pmid: 10195093
references.citation: Medicine (Baltimore). 2012 Sep;91(5):261-73
references.pmid: 22932790
references.citation: J Heart Lung Transplant. 2002 Mar;21(3):391-4
references.pmid: 11897529
references.citation: Am J Respir Crit Care Med. 1994 Jun;149(6):1601-7
references.pmid: 7516251
references.citation: Thorax. 2008 Aug;63(8):732-7
references.pmid: 18408050
references.citation: Dig Dis Sci. 1992 Sep;37(9):1464-8
references.pmid: 1505297
references.citation: Ther Drug Monit. 2013 Feb;35(1):133-6
references.pmid: 23188182
references.citation: Chest. 1998 Nov;114(5):1321-9
references.pmid: 9824009
references.citation: J Heart Lung Transplant. 2007 Sep;26(9):890-7
references.pmid: 17845927
references.citation: Am J Respir Crit Care Med. 2001 Jan;163(1):43-8
references.pmid: 11208624
references.citation: J Clin Epidemiol. 1990;43(2):125-31
references.pmid: 2303842
references.citation: Curr Opin Infect Dis. 2013 Aug;26(4):317-25
references.pmid: 23743815
references.citation: Clin Microbiol Infect. 2005 May;11(5):359-65
references.pmid: 15819861
references.citation: Semin Respir Crit Care Med. 2009 Oct;30(5):596-610
references.pmid: 19760547
references.citation: Thorax. 1997 Apr;52(4):318-21
references.pmid: 9196512
references.citation: J Heart Lung Transplant. 2006 Dec;25(12):1447-55
references.pmid: 17178340
references.citation: Eur Respir J. 2004 Feb;23(2):334-42
references.pmid: 14979513
references.citation: J Clin Microbiol. 2000 May;38(5):1763-6
references.pmid: 10790095
references.citation: Clin Infect Dis. 2010 Jun 15;50(12):1559-67
references.pmid: 20450350
references.citation: J Clin Microbiol. 2001 Oct;39(10):3427-36
references.pmid: 11574551
references.citation: Eur J Clin Microbiol Infect Dis. 2009 Oct;28(10):1275-9
references.pmid: 19575248
references.citation: Pulm Med. 2014;2014:621342
references.pmid: 24800072
references.citation: Am J Respir Crit Care Med. 2005 Jan 15;171(2):158-64
references.pmid: 15502116
references.citation: Ann Thorac Surg. 1992 Jul;54(1):27-31; discussion 31-2
references.pmid: 1610249
references.citation: J Heart Lung Transplant. 2003 Jul;22(7):764-9
references.pmid: 12873544
references.citation: Chest. 1998 May;113(5):1230-4
references.pmid: 9596299
references.citation: Transplantation. 2006 Feb 15;81(3):320-6
references.pmid: 16477215
references.citation: Am J Respir Crit Care Med. 2012 Jan 15;185(2):231-2
references.pmid: 22246710
references.citation: Transpl Int. 2015 Jan;28(1):129-33
references.pmid: 25070399
references.citation: Pediatr Transplant. 2013 May;17(3):271-7
references.pmid: 23489441
references.citation: Clin Microbiol Infect. 2011 Sep;17(9):1381-6
references.pmid: 21087348
references.citation: Transplantation. 1996 Mar 27;61(6):915-9
references.pmid: 8623160
references.citation: Transplantation. 2014 Feb 15;97(3):351-7
references.pmid: 24305637
references.citation: Lancet. 1993 Jul 3;342(8862):15-9
references.pmid: 7686239
references.citation: Semin Respir Crit Care Med. 2013 Jun;34(3):297-304
references.pmid: 23821505
references.citation: Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
references.pmid: 17277290
references.citation: J Natl Cancer Inst. 2013 Jan 16;105(2):122-9
references.pmid: 23178438
references.citation: Am J Respir Crit Care Med. 1995 Jul;152(1):374-6
references.pmid: 7599848
references.citation: Eur J Clin Microbiol Infect Dis. 2007 Dec;26(12):879-86
references.pmid: 17874329
references.citation: Am J Respir Crit Care Med. 2003 Mar 15;167(6):828-34
references.pmid: 12433668
references.citation: J Heart Lung Transplant. 2006 Jul;25(7):745-55
references.pmid: 16818116
references.citation: Semin Respir Crit Care Med. 2013 Jun;34(3):371-9
references.pmid: 23821511
references.citation: Clin Infect Dis. 2010 Apr 15;50(8):1101-11
references.pmid: 20218876
references.citation: Am J Respir Crit Care Med. 1997 May;155(5):1699-704
references.pmid: 9154879
references.citation: Thorax. 2006 Jun;61(6):507-13
references.pmid: 16601086
references.citation: Am J Transplant. 2004 Apr;4(4):583-95
references.pmid: 15023151
references.citation: Am J Respir Crit Care Med. 2011 Jul 15;184(2):159-71
references.pmid: 21471083
references.citation: Ann Thorac Surg. 1993 May;55(5):1087-91; discussion 1091-2
references.pmid: 8494415
references.citation: Chest. 1987 Apr;91(4):527-32
references.pmid: 3829745
references.citation: Transplant Proc. 2013 Jan-Feb;45(1):346-8
references.pmid: 23375321
references.citation: Ann Thorac Surg. 2002 Jul;74(1):13-7; discussion 17-8
references.pmid: 12118744
references.citation: Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):552-6
references.pmid: 1654038
references.citation: Transplantation. 2004 Jan 27;77(2):232-7
references.pmid: 14742987
references.citation: Am J Transplant. 2004 May;4(5):796-802
references.pmid: 15084177
references.citation: Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1572-7
references.pmid: 10556123
references.citation: J Heart Transplant. 1990 Sep-Oct;9(5):459-66; discussion 466-7
references.pmid: 2231084
references.citation: Chest. 2000 Feb;117(2):476-81
references.pmid: 10669693
references.citation: Clin Infect Dis. 2004 May 15;38(10):1428-39
references.pmid: 15156482
references.citation: J Thorac Cardiovasc Surg. 2011 Oct;142(4):755-61
references.pmid: 21924145
references.citation: Clin Microbiol Infect. 2010 Jun;16(6):689-95
references.pmid: 19689467
references.citation: Eur J Clin Microbiol Infect Dis. 2003 Jan;22(1):28-34
references.pmid: 12582741
references.citation: Cancer. 2010 Nov 15;116(22):5290-6
references.pmid: 20665889
references.citation: Diabetes Care. 2010 Feb;33(2):311-6
references.pmid: 19918014
references.citation: Emerg Infect Dis. 2003 Dec;9(12):1587-91
references.pmid: 14720400
references.citation: Transplant Proc. 2010 Dec;42(10):4459-64
references.pmid: 21168718
references.citation: J Antimicrob Chemother. 2008 May;61(5):1057-61
references.pmid: 18316821
references.citation: Pediatr Infect Dis J. 2007 Mar;26(3):263-4
references.pmid: 17484227
references.citation: Pediatr Transplant. 2001 Oct;5(5):339-42
references.pmid: 11560752
references.citation: Am J Transplant. 2011 Feb;11(2):361-6
references.pmid: 21272239
references.citation: Am J Gastroenterol. 2012 Sep;107(9):1346-53
references.pmid: 22777342
references.citation: Clin Transplant. 2002 Aug;16(4):257-61
references.pmid: 12099981
references.citation: Transpl Infect Dis. 2010 Aug 1;12(4):309-15
references.pmid: 20202177
references.citation: Am J Respir Crit Care Med. 2008 Aug 15;178(4):363-71
references.pmid: 18535253
references.citation: Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):941-6
references.pmid: 10988110
references.citation: Antimicrob Agents Chemother. 2010 Oct;54(10):4424-31
references.pmid: 20679503
references.citation: Transplant Proc. 2005 Jul-Aug;37(6):2682-3
references.pmid: 16182783
references.citation: Genome Announc. 2013 Aug 15;1(4):null
references.pmid: 23950125
references.citation: Chest. 1995 May;107(5):1323-7
references.pmid: 7750326
references.citation: Transplantation. 2001 Jan 27;71(2):242-6
references.pmid: 11213067
references.citation: Radiology. 2005 Apr;235(1):282-8
references.pmid: 15703315
references.citation: Am J Respir Crit Care Med. 2003 Mar 15;167(6):835-40
references.pmid: 12433669
references.citation: Am J Transplant. 2008 May;8(5):1025-30
references.pmid: 18318775
references.citation: J Heart Lung Transplant. 1991 Nov-Dec;10(6):877-86; discussion 886-7
references.pmid: 1661607
references.citation: Transpl Infect Dis. 2002 Dec;4(4):195-200
references.pmid: 12535262
references.citation: Ann Transplant. 2000;5(3):13-9
references.pmid: 11147024
references.citation: Pediatr Transplant. 2013 May;17(3):224-30
references.pmid: 23050564
references.citation: Med Mycol Case Rep. 2013 May 23;2:116-8
references.pmid: 24432232
references.citation: Eur Respir J. 2005 Jun;25(6):964-9
references.pmid: 15929949
references.citation: Transplant Proc. 1998 Aug;30(5):2261-3
references.pmid: 9723463
references.citation: Transplantation. 2012 Apr 15;93(7):729-36
references.pmid: 22415051
references.citation: Am J Respir Crit Care Med. 2006 Feb 15;173(4):421-5
references.pmid: 16272450
references.citation: Diabetes Care. 2005 Sep;28(9):2141-4
references.pmid: 16123480
references.citation: Am J Respir Crit Care Med. 2008 Jan 1;177(1):114-20
references.pmid: 17901410
references.citation: Am J Respir Crit Care Med. 2012 Apr 1;185(7):763-8
references.pmid: 22268135
references.citation: Pediatr Transplant. 1998 Aug;2(3):185-90
references.pmid: 10084740
references.citation: J Heart Lung Transplant. 2003 Oct;22(10):1168-73
references.pmid: 14550827
references.citation: J Thorac Cardiovasc Surg. 2010 Mar;139(3):765-773.e1
references.pmid: 19931096
references.citation: Br J Dis Chest. 1984 Jul;78(3):299-302
references.pmid: 6743529
references.citation: Am J Transplant. 2006 Oct;6(10):2365-74
references.pmid: 16925570
references.citation: J Thorac Cardiovasc Surg. 1991 Apr;101(4):633-41; discussion 641-2
references.pmid: 2008101
references.citation: Am J Transplant. 2010 Sep;10(9):2173-8
references.pmid: 20636463
references.citation: Am J Respir Crit Care Med. 2001 Dec 1;164(11):2102-6
references.pmid: 11739142
references.citation: Eur Respir J. 1997 Apr;10(4):952-4
references.pmid: 9150340
references.citation: Eur Respir J. 2008 May;31(5):1037-45
references.pmid: 18256072
references.citation: J R Soc Med. 1996;89 Suppl 27:38-43
references.pmid: 8778449
references.citation: J Cyst Fibros. 2015 Jan;14(1):46-52
references.pmid: 25178871
references.citation: Arch Intern Med. 2001 Feb 26;161(4):525-33
references.pmid: 11252111
references.citation: J Heart Lung Transplant. 2003 Aug;22(8):894-902
references.pmid: 12909470
references.citation: J Heart Lung Transplant. 1994 Jan-Feb;13(1 Pt 1):15-21; discussion 22-3
references.pmid: 7513185
references.citation: Transplantation. 2008 Mar 15;85(5):771-4
references.pmid: 18337673
references.citation: Eur J Cardiothorac Surg. 2002 Oct;22(4):602-9
references.pmid: 12297180
references.citation: J Clin Gastroenterol. 2009 Oct;43(9):858-64
references.pmid: 19525864
references.citation: Am J Transplant. 2013 Mar;13 Suppl 4:228-41
references.pmid: 23465016
references.citation: Eur J Clin Microbiol Infect Dis. 2000 Jan;19(1):53-6
references.pmid: 10706182
references.citation: J Heart Lung Transplant. 2004 Dec;23(12):1451-4
references.pmid: 15607679
references.citation: Drugs. 2004;64(2):133-47
references.pmid: 14717616
references.citation: J Heart Lung Transplant. 2014 Oct;33(10):1009-24
references.pmid: 25242125
references.citation: Proc Am Thorac Soc. 2009 Jan 15;6(1):94-100
references.pmid: 19131534
references.citation: J Clin Microbiol. 2004 Apr;42(4):1491-7
references.pmid: 15070994
references.citation: Chest. 1993 Feb;103(2):466-71
references.pmid: 7679347
references.citation: Clin Infect Dis. 2001 May 1;32(9):1298-303
references.pmid: 11303264
references.citation: Chest. 2002 May;121(5):1714-6
references.pmid: 12006471
references.citation: Clin Transplant. 2013 Mar-Apr;27(2):303-10
references.pmid: 23316931
references.citation: J Cyst Fibros. 2013 Dec;12(6):575-83
references.pmid: 23757360
references.citation: Am J Respir Crit Care Med. 2000 Dec;162(6):2241-5
references.pmid: 11112146
references.citation: J Bone Miner Metab. 2015 Mar;33(2):180-5
references.pmid: 24633535
references.citation: Med Mycol. 2009 Jun;47(4):387-97
references.pmid: 19107638
references.citation: Chest. 1996 May;109(5):1176-83
references.pmid: 8625663
references.citation: Pediatr Transplant. 2001 Feb;5(1):27-31
references.pmid: 11260485
references.citation: Am Rev Respir Dis. 1989 Sep;140(3):802-5
references.pmid: 2506786
references.citation: J Cyst Fibros. 2013 May;12(3):187-93
references.pmid: 23491855
references.citation: Am J Transplant. 2007 Aug;7(8):1989-96
references.pmid: 17617864
references.citation: J Pediatr Surg. 2014 Feb;49(2):280-3
references.pmid: 24528967
references.citation: J Heart Lung Transplant. 2012 Jul;31(7):694-9
references.pmid: 22484291
references.citation: J Heart Lung Transplant. 2007 Feb;26(2):127-31
references.pmid: 17258145
references.citation: Transplantation. 2001 Oct 15;72(7):1251-5
references.pmid: 11602851
references.citation: Antimicrob Agents Chemother. 2007 Mar;51(3):1085-8
references.pmid: 17158942
references.citation: Heart Lung. 2010 Mar-Apr;39(2):153-9
references.pmid: 20207276
references.citation: J Cyst Fibros. 2014 Jul;13(4):416-23
references.pmid: 24388063
references.citation: Chest. 2003 Nov;124(5):1689-93
references.pmid: 14605036
references.citation: Am J Transplant. 2006 Dec;6(12):3008-16
references.pmid: 17062003
references.citation: Am J Respir Crit Care Med. 2002 Dec 15;166(12 Pt 1):1550-5
references.pmid: 12406843
references.citation: Clin Transplant. 2005 Dec;19(6):773-8
references.pmid: 16313324
references.citation: J Heart Lung Transplant. 2010 Nov;29(11):1240-4
references.pmid: 20591690
references.citation: Transpl Infect Dis. 2001 Dec;3(4):189-94
references.pmid: 11844150
references.citation: J Thorac Cardiovasc Surg. 2000 Apr;119(4 Pt 1):682-9
references.pmid: 10733756
references.citation: N Engl J Med. 2002 Aug 8;347(6):408-15
references.pmid: 12167683
references.citation: J Cyst Fibros. 2015 Jan;14(1):53-62
references.pmid: 24917112
references.citation: Transpl Infect Dis. 2012 Oct;14(5):452-60
references.pmid: 22676720
references.citation: Chest. 2003 Jan;123(1):37-41
references.pmid: 12527600
references.citation: Clin Infect Dis. 2003 Oct 1;37 Suppl 3:S157-87
references.pmid: 12975751
references.citation: Eur J Pediatr Surg. 1998 Oct;8(5):274-7
references.pmid: 9825236
references.citation: Pediatr Pulmonol. 1998 Aug;26(2):89-96
references.pmid: 9727758
references.citation: N Engl J Med. 1992 Apr 30;326(18):1187-91
references.pmid: 1285737
references.citation: J Heart Lung Transplant. 2013 Sep;32(9):905-13
references.pmid: 23953818
references.citation: Transplantation. 2004 Jan 15;77(1):134-6
references.pmid: 14724449
references.citation: Clin Infect Dis. 2001 Nov 1;33(9):1469-75
references.pmid: 11588691
references.citation: J Pediatr. 2001 Nov;139(5):643-9
references.pmid: 11713440
references.citation: Int J Pediatr Otorhinolaryngol. 2001 Nov 1;61(2):113-9
references.pmid: 11589977
references.citation: Chest. 1997 Nov 5;112(5):1160-4
references.pmid: 9367451
references.citation: Pediatr Pulmonol. 2013 Dec;48(12):1181-9
references.pmid: 23825099
references.citation: J Heart Lung Transplant. 2011 Jul;30(7):790-8
references.pmid: 21482148
references.citation: J Cyst Fibros. 2012 Mar;11(2):158-61
references.pmid: 22133899
references.citation: Pediatr Pulmonol. 2005 Jul;40(1):68-71
references.pmid: 15880421
references.citation: Lancet. 2001 Nov 24;358(9295):1780-1
references.pmid: 11734238
references.citation: Diabetes Care. 2010 Dec;33(12):2697-708
references.pmid: 21115772
references.citation: J Heart Lung Transplant. 2001 Apr;20(4):486-9
references.pmid: 11295588
references.citation: Paediatr Respir Rev. 2012 Dec;13(4):206-14
references.pmid: 23069117
references.citation: Expert Rev Respir Med. 2014 Jun;8(3):315-26
references.pmid: 24655065
references.citation: Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):819-25
references.pmid: 10988089
references.citation: Eur J Clin Microbiol Infect Dis. 2010 Nov;29(11):1387-94
references.pmid: 20703506
references.citation: J Hosp Infect. 1998 Jan;38(1):19-26
references.pmid: 9513065
references.citation: Chest. 2001 Jan;119(1):169-75
references.pmid: 11157600
references.citation: J Thorac Cardiovasc Surg. 1996 Nov;112(5):1284-90; discussion 1290-1
references.pmid: 8911325
references.citation: Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 1):1611-6
references.pmid: 10556129
references.citation: Medicine (Baltimore). 2002 Sep;81(5):333-48
references.pmid: 12352630
references.citation: Am J Epidemiol. 2001 Feb 15;153(4):345-52
references.pmid: 11207152
references.citation: Chest. 1997 Oct;112(4):924-30
references.pmid: 9377954
references.citation: Am J Respir Crit Care Med. 2014 Oct 15;190(8):898-905
references.pmid: 25222938
references.citation: Chest. 2003 Mar;123(3):800-8
references.pmid: 12628881
references.citation: Eur J Cardiothorac Surg. 2014 Feb;45(2):365-9; discussion 369-70
references.pmid: 23900745
references.citation: Clin Infect Dis. 2001 Apr 15;32(8):1237-40
references.pmid: 11283817
references.citation: J Heart Lung Transplant. 2003 Apr;22(4):433-8
references.pmid: 12681421
references.citation: Am J Transplant. 2011 Oct;11(10):2197-204
references.pmid: 21831157
references.citation: Chest. 2003 Jan;123(1):217-21
references.pmid: 12527625
references.citation: Clin Infect Dis. 2004 May 1;38(9):1243-50
references.pmid: 15127335
references.citation: Mycoses. 2013 May;56(3):304-10
references.pmid: 23170837
references.citation: J Cyst Fibros. 2007 Sep;6(5):334-50
references.pmid: 17418647
references.citation: J Thorac Cardiovasc Surg. 2004 May;127(5):1493-501
references.pmid: 15116013
references.citation: N Engl J Med. 1992 Dec 10;327(24):1710-4
references.pmid: 1331789
references.citation: Chest. 2002 Jan;121(1):128-34
references.pmid: 11796441
references.citation: Scand J Infect Dis. 2012 Nov;44(11):835-41
references.pmid: 22803836
references.citation: Semin Respir Crit Care Med. 2011 Dec;32(6):693-702
references.pmid: 22167397
references.citation: Pediatr Pulmonol. 2000 Sep;30(3):267-8
references.pmid: 10973047
references.citation: N Engl J Med. 2007 Jan 25;356(4):348-59
references.pmid: 17251531
references.citation: Emerg Infect Dis. 2014 Mar;20(3):364-71
references.pmid: 24565502
references.citation: J Cyst Fibros. 2013 Sep;12(5):482-6
references.pmid: 23294530
references.citation: J Heart Lung Transplant. 1993 Jul-Aug;12(4):669-74
references.pmid: 8369328
references.citation: Thorax. 2004 Nov;59(11):952-4
references.pmid: 15516470
references.citation: Joint Bone Spine. 2012 Jan;79(1):73-7
references.pmid: 21733729
references.citation: Med Mycol. 2010 Nov;48 Suppl 1:S52-9
references.pmid: 21067331
references.citation: Clin Infect Dis. 1998 Nov;27(5):1266-77
references.pmid: 9827281
references.citation: Proc Am Thorac Soc. 2009 Dec;6(8):619-33
references.pmid: 20008865
references.citation: Transplant Proc. 2014 Jan-Feb;46(1):295-7
references.pmid: 24507071
references.citation: Ther Drug Monit. 2012 Feb;34(1):77-84
references.pmid: 22210097
references.citation: Paediatr Respir Rev. 2013 May;14 Suppl 1:22-5
references.pmid: 23518310
references.citation: J Med Microbiol. 2004 Jul;53(Pt 7):663-8
references.pmid: 15184539
references.citation: Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1252-5
references.pmid: 10764320
references.citation: Clin Infect Dis. 2011 May;52(10):1218-26
references.pmid: 21507918
references.citation: J Heart Lung Transplant. 2003 Mar;22(3):258-66
references.pmid: 12633692
references.citation: Semin Respir Crit Care Med. 2003 Dec;24(6):681-92
references.pmid: 16088584
references.citation: Semin Respir Crit Care Med. 2003 Dec;24(6):703-16
references.pmid: 16088586
references.citation: Eur Respir J. 2013 May;41(5):1230-2
references.pmid: 23633613
references.citation: Curr Opin Infect Dis. 2012 Apr;25(2):218-27
references.pmid: 22327466
references.citation: Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1712-7
references.pmid: 8970360
references.citation: J Bacteriol. 2009 Jan;191(1):261-77
references.pmid: 18931103
references.citation: Transpl Infect Dis. 2013 Jun;15(3):233-42
references.pmid: 23432974
references.citation: Transpl Infect Dis. 2007 Jun;9(2):121-5
references.pmid: 17461997
references.citation: J Heart Lung Transplant. 2010 Dec;29(12):1395-404
references.pmid: 20810293
references.citation: Thorax. 2008 Aug;63(8):725-31
references.pmid: 18487317
references.citation: Paediatr Respir Rev. 2008 Sep;9(3):213-9
references.pmid: 18694713
references.citation: Diabetes Care. 2009 Sep;32(9):1626-31
references.pmid: 19542209
references.citation: J Cyst Fibros. 2009 Dec;8(6):386-91
references.pmid: 19740710
references.citation: Eur Respir J. 2013 Aug;42(2):542-4
references.pmid: 23904550
references.citation: Thorax. 2002 Feb;57(2):142-5
references.pmid: 11828044
references.citation: Chest. 1999 Mar;115(3):741-5
references.pmid: 10084486
references.citation: Thorax. 1996 Apr;51(4):374-7
references.pmid: 8733488
references.citation: Ann Intern Med. 1998 Feb 1;128(3):186-93
references.pmid: 9454526
references.citation: Chest. 1998 May;113(5):1235-43
references.pmid: 9596300
references.citation: Semin Respir Crit Care Med. 2011 Aug;32(4):471-93
references.pmid: 21858751
references.citation: J Thorac Cardiovasc Surg. 2004 Dec;128(6):933-40
references.pmid: 15573079
references.citation: J Pediatr. 1998 Jan;132(1):177-9
references.pmid: 9470027
references.citation: Thorax. 1990 May;45(5):397-400
references.pmid: 2382245