title: Neural correlates of taste and pleasantness evaluation in the metabolic syndrome.
abstract: Metabolic syndrome (MetS) is a constellation of cardiometabolic abnormalities that commonly occur together and increase risk for cardiovascular disease and type II diabetes. Having MetS, especially during middle-age, increases the risk for dementia in later life. Abdominal obesity is a central feature of MetS; therefore, increased efforts to prevent obesity and identify predictors of weight gain are of extreme importance. Altered processing of food reward in the brain of obese individuals has been suggested to be a possible mechanism related to overeating. We scanned fifteen healthy middle-aged controls (aged 44-54) and sixteen middle-aged adults with MetS after a fast (hungry) and after a preload (sated), while they rated the pleasantness of sucrose (sweet) and caffeine (bitter) solutions. Data were analyzed using voxelwise linear mixed-effects modeling, and a region of interest analysis to examine associations between hypothalamic activation to sweet taste and BMI during hunger and satiety. The results indicate that middle-aged individuals with MetS respond with significantly less brain activation than controls without MetS during pleasantness evaluation of sweet and bitter tastes in regions involved in sensory and higher-level taste processing. Participants with higher BMI had greater hypothalamic response during pleasantness evaluation of sucrose in the sated condition. Importantly, this study is the first to document differential brain circuitry in middle-aged adults with MetS, a population at risk for poor physical and cognitive outcomes. Future research aimed at better understanding relationships among MetS, obesity, and brain function is warranted to better conceptualize and develop interventions for overeating in these disorders.
authors.affiliation: San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
authors.forename: Erin
authors.initials: E
authors.lastname: Green
authors.affiliation: Department of Psychology, San Diego State University, San Diego, CA, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Jacobson
authors.affiliation: Department of Psychiatry, University of California, San Diego School of Medicine, San Diego, CA, USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Haase
authors.affiliation: San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Department of Psychology, San Diego State University, San Diego, CA, USA; Division of Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, USA. Electronic address: cmurphy@mail.sdsu.edu.
authors.forename: Claire
authors.initials: C
authors.lastname: Murphy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000254:growth & development / Q000503:physiopathology*; D001931:Brain Mapping; D002110:Caffeine; D019422:Dietary Sucrose; D005260:Female; D006801:Humans; D006815:Hunger / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008659:Metabolic Diseases / Q000503:physiopathology*; D008875:Middle Aged; D055696:Olfactory Perception / Q000502:physiology; D011601:Psychophysics; D012527:Satiation / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D055697:Taste Perception / Q000502:physiology*
chemical_list: D019422:Dietary Sucrose; D002110:Caffeine
keywords: Aging; Hunger; Metabolic syndrome; Obesity; Reward; Satiety; Taste; fMRI
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