title: Highly enantioselective transfer hydrogenation of ketones with chiral (NH)2 P2 macrocyclic iron(II) complexes.
abstract: Bis(isonitrile) iron(II) complexes bearing a C2 -symmetric diamino (NH)2 P2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad scope of substrates (ketones, enones, and imines) in high yield (up to 99.5 %), excellent enantioselectivity (up to 99 % ee), and with low catalyst loading (generally 0.1 mol %). The catalyst can be easily tuned by modifying the substituents of the isonitrile ligand.
authors.affiliation: Departement Chemie und Angewandte Biowissenschaften, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich (Switzerland).
authors.forename: Raphael
authors.initials: R
authors.lastname: Bigler
authors.forename: Raffael
authors.initials: R
authors.lastname: Huber
authors.forename: Antonio
authors.initials: A
authors.lastname: Mezzetti
keywords: alcohols; asymmetric catalysis; hydrogen transfer; iron; macrocyclic ligands