title: Synthesis and properties of antifouling poly(CL-co-zDMAEMA) zwitterionic copolymer by one-step hybrid copolymerization.
abstract: A novel biocompatible and biodegradable copolymer was synthesized by one-step hybrid copolymerization of ε-caprolactone (CL) and 2-(N,N-dimethylamino) ethyl methacrylate (DMAEMA) employing (1-tert-butyl-4,4,4-tris(dimethylamino)-2,2-bis[tris(dimethylamino)phophoranylidenamino]-2Λ5,Λ5-catenadi(phosphazene) (t-BuP4) as a catalyst. The as-synthesized copolymer was betainizated resulting in a zwitterionic copolymer poly(CL-co-zDMAEMA) and the structure of the zwitterionic copolymer was confirmed by the FT-IR, NMR, and XPS measurements. The results of dynamic light scattering (DLS) show that this zwitterionic copolymer can self-assemble into stable micelles. The results of quartz crystal microbalance with dissipation (QCM-D) analysis and MTT measurement suggest that this zwitterionic copolymer possess better protein resistance and lower cell cytotoxicity in vitro in comparison with the cationic copolymer. The pyrene solubilization measurement of copolymers poly(CL-co-zDMAEMA) indicates an excellent pyrene solubilization capacity. These zwitterionic polymer micelles can release drugs in response to specific signals, such as temperature, pH, and enzymes and have a potential application in drug delivery and gene therapy due to their good antifouling, low cytotoxicity and high pyrene solubilization.
authors.affiliation: College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China. Electronic address: yanmanq@ahu.edu.cn.
authors.forename: Manqing
authors.initials: M
authors.lastname: Yan
authors.affiliation: Jiangsu Key Laboratory of Material Surface Technology, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Yang
authors.affiliation: Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 5106409, China. Electronic address: msgzzhang@scut.edu.cn.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Zhang
mesh_terms: D002470:Cell Survival / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000633:toxicity*; D008823:Micelles; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity*; D011108:Polymers / Q000138:chemical synthesis / Q000633:toxicity; D013499:Surface Properties
chemical_list: D008689:Methacrylates; D008823:Micelles; D053769:Nanocapsules; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; C049840:2-(dimethylamino)ethyl methacrylate
keywords: Antifouling; Cationic copolymer; Hybrid copolymerization; Poly(ε-caprolactone-co-N,N-dimethylaminoethyl methacrylate) copolymer; Zwitterionic copolymer