title: Is high dose rate brachytherapy reliable and effective treatment for prostate cancer patients? A review of the literature.
abstract: The intrinsic physical and radiobiological characteristics of High Dose Rate Brachytherapy (HDR-BT) are well suited to the treatment of prostate cancer. HDR-BT was initially used as a boost to external beam brachytherapy, but has subsequently been employed as the sole treatment, which is termed HDR monotherapy. This review summarizes the clinical outcomes and toxicity results of the principal studies and discusses the radiobiological basis supporting its use.
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. Electronic address: berardino.de-bari@chuv.ch.
authors.forename: Berardino
authors.initials: B
authors.lastname: De Bari
authors.affiliation: Radiation Oncology Department, University of Palermo, Palermo, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Daidone
authors.affiliation: Radiation Oncology Department, Sacro Cuore-Don Calabria Hospital, Negrar-Verona, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Alongi
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods; D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D016879:Salvage Therapy; D016896:Treatment Outcome
keywords: Brachytherapy boost, Radiobiology.; HDR-BT; High-dose rate brachytherapy; Prostate cancer; Salvage brachytherapy