title: Superoxide Dismutase and Catalase Genotypes in Pediatric Migraine Patients.
abstract: This study compared superoxide dismutase (SOD) and catalase (CAT) alleles in 97 consecutive children and adolescents with migraine to 96 healthy children and adolescents. Isolated genomic DNA was used as a template for SOD1 (35 A/C), SOD2 16 C/T, and CAT2 [(-262 C/T) and (-21 A/T)] allele genotyping. The SOD2 16 C/T genotype and C allele frequency differed significantly between controls and migraine (P = .047; P = .038). CAT -21 AA genotype and A allele frequency were significantly higher in both migraine with aura patients (P = .013; P = .004) and migraine without aura patients (P = .003; P = .001) compared to controls. To our knowledge, this is the first demonstration of differences in SOD and CAT genotypes between pediatric migraine patients and age-matched controls. Further studies on the functional implications of these genetic variants on neural antioxidant capacity and the use of antioxidant modulators for migraine treatment are warranted.
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey semra_saygi@yahoo.com.
authors.forename: Semra
authors.initials: S
authors.lastname: Saygi
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: İlknur
authors.initials: İ
authors.lastname: Erol
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Baskent University Faculty of Medicine, Adana, Turkey.
authors.forename: Füsun
authors.initials: F
authors.lastname: Alehan
authors.affiliation: Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
authors.forename: Yaprak Yılmaz
authors.initials: YY
authors.lastname: Yalçın
authors.affiliation: Kazan Vocational School Business Administration Program, Baskent University, Ankara, Turkey.
authors.forename: Gözde
authors.initials: G
authors.lastname: Kubat
authors.affiliation: Department of Medical Biology, Baskent University School of Medicine, Ankara, Turkey.
authors.forename: Fatma Belgin
authors.initials: FB
authors.lastname: Ataç
mesh_terms: D000293:Adolescent; D002374:Catalase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000201:enzymology / Q000235:genetics*; D020326:Migraine without Aura / Q000201:enzymology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics*; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2
chemical_list: D002374:Catalase; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1; D000099156:Superoxide Dismutase 2; C000606290:SOD1 protein, human
keywords: catalase; children; gene polymorphism; migraine; oxidative stress; superoxide dismutases