title: Physical Activity Predicts Higher Physical Function in Older Adults: The Osteoarthritis Initiative.
abstract: OBJECTIVE
  Physical activity reduces mobility impairments in elders. We examined the association of physical activity on risk of subjective and objective physical function in adults with and at risk for osteoarthritis (OA).
  
  
  METHODS
  Adults aged ≥ 60 years from the longitudinal Osteoarthritis Initiative, a prospective observational study of knee OA, were classified by sex-specific quartiles of Physical Activity Score for the Elderly scores. Using linear mixed models, we assessed 6-year data on self-reported health, gait speed, Late-Life Function and Disability Index (LLFDI) and chair stand.
  
  
  RESULTS
  Of 2252 subjects, mean age ranged from 66 to 70 years. Within each quartile, physical component (PCS) of the Short Form-12 and gait speed decreased from baseline to follow-up in both sexes (all P < .001), yet the overall changes across PASE quartiles between these 2 time points were no different (P = .40 and .69, males and females, respectively). Decline in PCS occurred in the younger age group, but rates of change between quartiles over time were no different in any outcomes in either sex. LLFDI scores declined in the 70+ age group. Adjusting for knee extensor strength reduced the strength of association.
  
  
  CONCLUSIONS
  Higher physical activity is associated with maintained physical function and is mediated by muscle strength, highlighting the importance of encouraging physical activity in older adults with and at risk for OA.
authors.affiliation: Section of General Internal Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.
authors.forename: John A
authors.initials: JA
authors.lastname: Batsis
authors.forename: Cassandra M
authors.initials: CM
authors.lastname: Germain
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Vásquez
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Zbehlik
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Bartels
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010003:Osteoarthritis / Q000503:physiopathology*; D011446:Prospective Studies; D016896:Treatment Outcome
references.citation: Arthritis Rheum. 2009 Nov;60(11):3374-7
references.pmid: 19877065
references.citation: Med Sci Sports Exerc. 2009 Jul;41(7):1510-30
references.pmid: 19516148
references.citation: J Clin Endocrinol Metab. 2011 May;96(5):1462-8
references.pmid: 21325457
references.citation: Circulation. 2007 Nov 6;116(19):2110-8
references.pmid: 17967770
references.citation: Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):693-700
references.pmid: 18827572
references.citation: JAMA. 2011 Jan 5;305(1):50-8
references.pmid: 21205966
references.citation: Am J Public Health Nations Health. 1964 Sep;54:1568-79
references.pmid: 14218194
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Oct;56 Spec No 2:23-35
references.pmid: 11730235
references.citation: Nutr J. 2014 Aug 09;13:81
references.pmid: 25106459
references.citation: J Am Geriatr Soc. 2004 Sep;52(9):1554-9
references.pmid: 15341561
references.citation: Qual Health Care. 1994 Mar;3(1):11-6
references.pmid: 10171955
references.citation: Ann Rheum Dis. 2004 Feb;63(2):200-5
references.pmid: 14722211
references.citation: Heart. 2014 Jul;100(13):1037-42
references.pmid: 24829373
references.citation: Am J Prev Med. 2003 Oct;25(3 Suppl 2):204-8
references.pmid: 14552945
references.citation: J Clin Epidemiol. 1994 Jul;47(7):809-15
references.pmid: 7722594
references.citation: BMC Musculoskelet Disord. 2012 Feb 21;13:26
references.pmid: 22353558
references.citation: J Vestib Res. 2006;16(4-5):233-43
references.pmid: 17538213
references.citation: N Engl J Med. 2003 Jan 2;348(1):42-9
references.pmid: 12510042
references.citation: PLoS One. 2012;7(9):e45602
references.pmid: 23029128
references.citation: J Clin Epidemiol. 1993 Feb;46(2):153-62
references.pmid: 8437031
references.citation: J Gerontol A Biol Sci Med Sci. 2014 May;69(5):547-58
references.pmid: 24737557
references.citation: Gerontologist. 1995 Aug;35(4):451-62
references.pmid: 7557515
references.citation: Am J Public Health. 1997 Mar;87(3):378-83
references.pmid: 9096537
references.citation: Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):239-46
references.pmid: 18525377
references.citation: J Chronic Dis. 1987;40(5):373-83
references.pmid: 3558716
references.citation: Phys Ther. 2006 Apr;86(4):520-40
references.pmid: 16579669
references.citation: BMJ. 2013 Sep 20;347:f5555
references.pmid: 24055922
references.citation: Diabetes Res Clin Pract. 2005 Jul;69(1):29-35
references.pmid: 15955385
references.citation: J Gerontol A Biol Sci Med Sci. 2011 May;66(5):577-81
references.pmid: 21382883
references.citation: Arthritis Rheum. 2008 Jan;58(1):26-35
references.pmid: 18163497
references.citation: Med Sci Sports Exerc. 2011 Nov;43(11):2189-94
references.pmid: 21502894
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
references.pmid: 11253156
references.citation: Eur J Intern Med. 2014 Jul;25(6):517-22
references.pmid: 24909976
references.citation: Circulation. 2011 Aug 16;124(7):789-95
references.pmid: 21810663
references.citation: Heart. 2014 Jul;100(13):1043-9
references.pmid: 24829374
references.citation: J Sports Med Phys Fitness. 1999 Dec;39(4):336-40
references.pmid: 10726435
references.citation: PM R. 2012 May;4(5 Suppl):S10-9
references.pmid: 22632687
references.citation: Ann Intern Med. 2002 Aug 6;137(3):208-15
references.pmid: 12160371
references.citation: J Aging Health. 2008 Oct;20(7):767-87
references.pmid: 18559963
references.citation: Arthritis Care Res (Hoboken). 2013 Jan;65(1):34-43
references.pmid: 22674832
references.citation: MMWR Morb Mortal Wkly Rep. 2007 Nov 23;56(46):1209-12
references.pmid: 18030281