title: Piceatannol lowers the blood glucose level in diabetic mice.
abstract: We previously found that passion fruit (Passiflora edulis) seeds contained a high amount of piceatannol (3,5,3',4'-trans-tetrahydroxystilbene), a natural analog of resveratrol (3,5,4'-trans-trihydroxystilbene). Resveratrol has been proposed as a potential anti-metabolic disorder compound, by its activation of sirtuin and AMP-activated protein kinase. Many reports show that resveratrol ameliorates diet-induced obesity and insulin resistance. However, it is not known whether piceatannol also affects diet-induced obesity. We explored the effect of piceatannol on high fat diet-fed mice. The results showed that piceatannol did not affect high fat diet-induced body weight gain or visceral fat gain in mice. However, piceatannol did reduce fasting blood glucose levels. Furthermore, to explore the potential of passion fruit seed extract containing piceatannol as a functional food, passion fruit seed extract was administered in a genetic diabetic mouse model (db/db mice). Single administration of passion fruit seed extract, as well as piceatannol reduced the blood glucose levels of these db/db mice. These results suggest that piceatannol and passion fruit seed extract may have potential application in the prevention of diabetes.
authors.affiliation: Health Science Research Center, Morinaga & Co., Ltd.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Uchida-Maruki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inagaki
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Ito
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kurita
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sai
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Ito
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D059305:Diet, High-Fat; D004435:Eating / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D020738:Leptin / Q000097:blood; D008297:Male; D008810:Mice, Inbred C57BL; D029598:Passiflora; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D020738:Leptin; D010936:Plant Extracts; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene