title: Metabolic and cardiovascular complications in the liver transplant recipient.
abstract: Metabolic syndrome (MS) is an established risk factor for atherosclerosis and cardiovascular disease that affects 20-30% of the adult population in the western world, correlating with increased incidence of cardiovascular disease. Survival following liver transplantation (LT) has been steadily improving over the last 2 decades, with graft loss becoming a relatively rare cause of morbidity and mortality post LT. The improvement in short-term survival following LT has resulted in an increased incidence of metabolic and cardiovascular complications, which affect the mid- and long term survival. Patients following LT typically gain weight and might develop diabetes, hypertension and dyslipidemia as a consequence of their immunosuppressive therapy and their lifestyle. In this paper we review the prevalence of metabolic and cardiovascular complications following LT, their impact on post-transplant morbidity and mortality and their optimal management.
authors.affiliation: Sheila Sherlock Liver Unit and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
authors.forename: Laura De
authors.initials: L
authors.lastname: Luca
authors.affiliation: Sheila Sherlock Liver Unit and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Westbrook
authors.affiliation: Sheila Sherlock Liver Unit and UCL Institute for Liver and Digestive Health, Royal Free Hospital, London, UK.
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Tsochatzis
keywords: Liver transplantation; NAFLD; NASH; cardiovascular disease; diabetes mellitus; dyslipidemia; epidemiology; hypertension; metabolic syndrome; morbidity; mortality; obesity; risk factors
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