title: DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status.
abstract: BACKGROUND
  Jorge Lobo's disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.
  
  
  METHODS
  DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).
  
  
  RESULTS
  The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.
  
  
  CONCLUSIONS
  These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
authors.affiliation: Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil ; Equipe Técnica de Biologia, Instituto Lauro de Souza Lima, Rod. Comte. João Ribeiro de Barros, km 225/226, CEP 17.034-971 Bauru, SP Brazil.
authors.forename: Adriana Sierra Assencio Almeida
authors.initials: AS
authors.lastname: Barbosa
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
authors.forename: Larissa Ragozo Cardoso
authors.initials: LR
authors.lastname: de Oliveira
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
authors.forename: Francilene Capel
authors.initials: FC
authors.lastname: Tavares
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
authors.forename: Carlos Roberto Gonçalves
authors.initials: CR
authors.lastname: de Lima
authors.affiliation: Microbiology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil.
authors.forename: Suzana Madeira
authors.initials: SM
authors.lastname: Diório
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
authors.forename: Sueli Aparecida
authors.initials: SA
authors.lastname: Calvi
authors.affiliation: Biology Technical Team, Lauro de Souza Lima Institute, Bauru, São Paulo State Brazil.
authors.forename: Fátima Regina
authors.initials: FR
authors.lastname: Vilani-Moreno
authors.affiliation: Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo State Brazil.
authors.forename: Paulo Câmara Marques
authors.initials: PC
authors.lastname: Pereira
keywords: Comet assay; Genotoxicity; Jorge Lobo’ disease; Lacazia loboi; Malnutrition; Mice
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