title: Investigations into Transition Metal Catalyzed Arene Trifluoromethylation Reactions.
abstract: Trifluoromethyl-substituted arenes and heteroarenes are widely prevalent in pharmaceuticals and agrochemicals. As a result, the development of practical methods for the formation of aryl-CF3bonds has become an active field of research. Over the past five years, transition metal catalyzed cross-coupling between aryl-X (X = halide, organometallic, or H) and various "CF3" reagents has emerged as a particularly exciting approach for generating aryl-CF3bonds. Despite many recent advances in this area, current methods generally suffer from limitations such as poor generality, harsh reaction conditions, the requirement for stoichiometric quantities of metals, and/or the use of costly CF3sources. This Account describes our recent efforts to address some of these challenges by: (1) developing aryl trifluoromethylation reactions involving high oxidation state Pd intermediates, (2) exploiting AgCF3for C-H trifluoromethylation, and (3) achieving Cu-catalyzed trifluoromethylation with photogenerated CF3•.
authors.affiliation: University of Michigan, Department of Chemistry, 930 North University Avenue, Ann Arbor, MI 48109, USA.
authors.forename: Yingda
authors.initials: Y
authors.lastname: Ye
authors.affiliation: University of Michigan, Department of Chemistry, 930 North University Avenue, Ann Arbor, MI 48109, USA.
authors.forename: Melanie S
authors.initials: MS
authors.lastname: Sanford
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