title: Radiotherapy and radioembolization for liver metastases.
abstract: Liver metastases are a common source of cancer-related morbidity. While systemic palliative chemotherapy is an option for patients with significant metastatic disease burden, radiotherapy (RT) is a safe, well-tolerated local treatment that can offer durable tumor control and relief of symptoms. Innovations in RT delivery now allow for treatment of liver metastases in one to five sessions with high local control rates. There is a growing body of Phase I-II data supporting the use of such RT techniques, including stereotactic body radiotherapy (SBRT) and radioembolization for the treatment of liver metastases. While there are a variety of local therapies available to patients with liver metastases, RT should be strongly considered in patients with liver metastasis related pain or oligometastatic disease not amenable to surgery. We recommend a multidisciplinary approach when weighing the risks and benefits of the available local treatment modalities for each patient.
authors.affiliation: Department of Radiation Oncology, Wayne State University, Barbara Ann Karmanos Cancer Center, Detroit, MI, USA. mdominel@med.wayne.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Dominello
authors.affiliation: Midwestern University, Glendale, AZ, USA.
authors.forename: John
authors.initials: J
authors.lastname: Bowers
authors.affiliation: Department of Radiation Oncology, Wayne State University, Barbara Ann Karmanos Cancer Center, Detroit, MI, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Zaki
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, The Chester County Hospital, West Chester, PA, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Konski
keywords: Liver metastases; palliation; radiation; radioembolization; stereotactic body radiotherapy (SBRT)