title: Prognostic factors of early morphological response to treatment with ranibizumab in patients with wet age-related macular degeneration.
abstract: Aim. To assess the significance of age, gender, baseline best corrected visual acuity, baseline macula thickness, and type and size of choroidal neovascularization in early morphological therapeutic response to ranibizumab treatment in patients with the wet form of age-related macular degeneration. Methods. From 09/2008 to 06/2013 we evaluated 1153 newly diagnosed, treatment-naïve patients treated with ranibizumab. Based on the morphological findings in the macula following the initial 3 injections of ranibizumab, the patients were divided into two groups based on active and inactive choroidal neovascularization. Results. After the initial 3 injections of ranibizumab, we examined the sample of 841 eyes with active CNV and 312 eyes with inactive CNV. In the inactive group, we found a statistically higher proportion of occult CNV (P < 0.001) and lower incidence of CNV greater than 5DA (P < 0.001) compared with the active group. We found no statistically significant difference in age, gender, baseline best corrected visual acuity, or baseline macula thickness between the inactive and active groups. Conclusion. Occult CNV and CNV smaller than 5DA are optimistic factors for a better morphological therapeutic response at the beginning of ranibizumab treatment.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
authors.forename: Oldřich
authors.initials: O
authors.lastname: Chrapek
authors.affiliation: Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University, Kamenice 126/3, 625 00 Brno, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Jarkovský
authors.affiliation: Department of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Šín
authors.affiliation: Department of Ophthalmology, Faculty of Medicine in Hradec Králové, Charles University in Prague and University Hospital in Hradec Králové, Sokolská 581, 500 03 Hradec Králové, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Studnička
authors.affiliation: Department of Ophthalmology, University Hospital, Jihlavská 340/20, 625 00 Brno, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Kolář
authors.affiliation: Department of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
authors.forename: Barbora
authors.initials: B
authors.lastname: Jirková
authors.affiliation: Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University, Kamenice 126/3, 625 00 Brno, Czech Republic.
authors.forename: Ladislav
authors.identifier: 0000-0002-8589-4378
authors.initials: L
authors.lastname: Dušek
authors.affiliation: Private Eye Clinic, V Hůrkách 1296/10, 158 00 Prague, Czech Republic.
authors.forename: Šárka
authors.initials: Š
authors.lastname: Pitrová
authors.affiliation: Department of Ophthalmology, Faculty of Medicine and Dentistry, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
authors.forename: Jiří
authors.initials: J
authors.lastname: Řehák
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