title: Targeted high-resolution ion mobility separation coupled to ultrahigh-resolution mass spectrometry of endocrine disruptors in complex mixtures.
abstract: Traditional separation and detection of targeted compounds from complex mixtures from environmental matrices requires the use of lengthy prefractionation steps and high-resolution mass analyzers due to the large number of chemical components and their large structural diversity (highly isomeric). In the present work, selected accumulation trapped ion mobility spectrometry (SA-TIMS) is coupled to Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) for direct separation and characterization of targeted endocrine-disrupting compounds (EDC) from a complex environmental matrix in a single analysis. In particular, targeted identification based on high-resolution mobility (R ∼ 70-120) and ultrahigh-resolution mass measurements (R > 400 000) of seven commonly targeted EDC and their isobars (e.g., bisphenol A, (Z)- and (E)-diethylstilbestrol, hexestrol, estrone, α-estradiol, and 17-ethynylestradiol) is shown from a complex mixture of water-soluble organic matter (e.g., Suwannee River Fulvic Acid Standard II) complemented with reference standard measurements and theoretical calculations (<3% error).
authors.affiliation: †Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.
authors.forename: Paolo
authors.initials: P
authors.lastname: Benigni
authors.affiliation: ‡Bruker Daltonics Inc., Billerica, Massachusetts 01821, United States.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Thompson
authors.affiliation: ‡Bruker Daltonics Inc., Billerica, Massachusetts 01821, United States.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Ridgeway
authors.affiliation: ‡Bruker Daltonics Inc., Billerica, Massachusetts 01821, United States.
authors.forename: Melvin A
authors.initials: MA
authors.lastname: Park
authors.affiliation: †Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, United States.|§Biomolecular Sciences Institute, Florida International University, Miami, Florida 33199, United States.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernandez-Lima
mesh_terms: D052244:Endocrine Disruptors / Q000032:analysis*; D013058:Mass Spectrometry; D009930:Organic Chemicals / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014867:Water / Q000737:chemistry*
chemical_list: D052244:Endocrine Disruptors; D009930:Organic Chemicals; D014867:Water
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