title: In vitro effects of rabeprazole on human pylorus tone.
abstract: OBJECTIVE
  It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle.
  
  
  METHODS
  Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and re-sponse to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled wa-ter was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10(-6), 10(-5), 10(-4), and 10(-3) M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured.
  
  
  RESULTS
  The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth in-tervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals.
  
  
  CONCLUSIONS
  In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Necdet Fatih
authors.identifier: http://orcid.org/0000-0002-9751-2912
authors.initials: NF
authors.lastname: Yaşar
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Erdal
authors.identifier: http://orcid.org/0000-0002-9463-9846
authors.initials: E
authors.lastname: Polat
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Mustafa
authors.identifier: http://orcid.org/0000-0002-0276-0543
authors.initials: M
authors.lastname: Duman
authors.affiliation: Department of Pharmacology, School of Medicine, Yeditepe University, Istanbul, Turkey.
authors.forename: Meltem
authors.identifier: http://orcid.org/0000-0001-6786-9606
authors.initials: M
authors.lastname: Dağdelen
authors.affiliation: Department of Physiology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Mehmet Yalcın
authors.identifier: http://orcid.org/0000-0001-7702-2441
authors.initials: MY
authors.lastname: Gunal
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Orhan
authors.identifier: http://orcid.org/0000-0001-7586-9075
authors.initials: O
authors.lastname: Uzun
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Cebrail
authors.identifier: http://orcid.org/0000-0003-0917-9345
authors.initials: C
authors.lastname: Akyuz
authors.affiliation: Department of Gastrointestinal Surgery, Kartal Kosuyolu Training and Research Hospital, Istanbul, Turkey.
authors.forename: Kıvanc Derya
authors.identifier: http://orcid.org/0000-0002-8887-3505
authors.initials: KD
authors.lastname: Peker
authors.affiliation: Division of Gastrointestinal Surgery, Department of General Surgery, School of Medicine, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
authors.forename: Sinan
authors.identifier: http://orcid.org/0000-0001-7631-0935
authors.initials: S
authors.lastname: Yol
keywords: Muscle tonus; Proton pump inhibitors; Pylorus; Rabeprazole
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