title: Comment on "Determination of the quaternary phase diagram of the water-ethylene glycol-sucrose-NaCl system and a comparison between two theoretical methods for synthetic phase diagrams" Cryobiology 61 (2010) 52-57.
abstract: Recently, measurements of a considerable portion of the phase diagram for the quaternary system water-ethylene glycol-sucrose-NaCl were published (Han et al., 2010). In that article, the data were used to evaluate the accuracy of two non-ideal multi-solute solution theories: the Elliott et al. form of the multi-solute osmotic virial equation and the Kleinhans and Mazur freezing point summation model. Based on this evaluation, it was concluded that the freezing point summation model provides more accurate predictions for the water-ethylene glycol-sucrose-NaCl system than the multi-solute osmotic virial equation. However, this analysis suffered from a number of issues, notably including the use of inconsistent solute-specific coefficients for the multi-solute osmotic virial equation. Herein, we reanalyse the data using a recently-updated and consistent set of solute-specific coefficients (Zielinski et al., 2014). Our results indicate that the two models have very similar performance, and, in fact, the multi-solute osmotic virial equation can provide more accurate predictions than the freezing point summation model depending on the concentration units used.
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2R8, Canada.
authors.forename: Michal W
authors.initials: MW
authors.lastname: Zielinski
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2R8, Canada.
authors.forename: Locksley E
authors.initials: LE
authors.lastname: McGann
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada.
authors.forename: John A
authors.initials: JA
authors.lastname: Nychka
authors.affiliation: Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 2V4, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2R8, Canada. Electronic address: janet.elliott@ualberta.ca.
authors.forename: Janet A W
authors.initials: JA
authors.lastname: Elliott
mesh_terms: D008962:Models, Theoretical; D044367:Phase Transition; D012996:Solutions / Q000737:chemistry*
chemical_list: D012996:Solutions
keywords: Ethylene glycol; Freezing point depression; Freezing point summation; Modeling; NaCl; Osmotic virial; Quaternary phase diagram; Sucrose; Thermodynamics