title: Causal relevance of circulating high-density lipoprotein cholesterol with cancer: a Mendelian randomization meta-analysis.
abstract: We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently by two authors. Data were analyzed by STATA software. Twenty-five articles that examined the associations of APOE gene ε2/ε3/ε4 polymorphism with either cancer risk (n = 22) or circulating lipid changes (n = 4) were eligible. The presence of ε2 and ε4 alleles showed no overall associations with overall cancer risk when compared with ε3 allele. The ε4 allele was significantly associated with 1.40-fold (odds ratio or OR = 1.40; 95% confidence interval or CI: 1.00-1.94; P = 0.047) increased risk of developing cancer in Asian populations, and the presence of heterogeneity was low (I(2) = 37.6%). Carriers of ε3/ε4 genotype had a significant reduction in circulating HDL-C (WMD = -2.62; 95% CI: -4.19 to -1.04; P = 0.001) without heterogeneity (I(2) = 16.6%). The predicted odds of having cancer for 1 mg/dL reduction in circulating HDL-C was 1.14 (95% CI: 1.00 to 1.89). The findings of this Mendelian randomization meta-analysis demonstrate that reduced circulating HDL-C might be a potentially causal risk factor for the development of overall cancer in Asians.
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Yang
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Tian
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Mi
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Wei
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Xuri
authors.initials: X
authors.lastname: Li
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Xianglin
authors.initials: X
authors.lastname: Li
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Wenming
authors.initials: W
authors.lastname: Wang
authors.affiliation: Medicine and Pharmacy Research Center, Binzhou Medical University, Laishan District, Yantai, Shandong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood*; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D009369:Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008055:Lipids
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