title: Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer.
abstract: OBJECTIVE
  This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer.
  
  
  METHODS
  Between May 2008 and April 2013, immunohistochemical staining for Ki-67 and p53 was performed in 34 patients with pancreatic head cancer (ductal adenocarcinoma). All 34 patients underwent pancreaticoduodenectomy at Chonnam National University Hwasun Hospital, Hwasun, Korea. Clinical and histopathological characteristics were analyzed, relative to p53 expression.
  
  
  RESULTS
  Thirty (88.2%) and twenty-one (61.7%) of the 34 pancreatic head cancers exhibited positive expression of Ki-67 and p53, respectively. Patients expressing Ki-67 and p53 experienced more frequent tumor recurrences within 1 year after surgical resection (P = 0.003 and P = 0.030, respectively). However, no correlation was detected between Ki-67 and p53 expression. Ki-67 expression was correlated with pathological grade, lymph node metasatsis, and clinical stage (P < 0.05). Importantly, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year in both univariable and multivariable analyses (odds ratio, 27.219; 95% confidence interval, 1.403-528.135; P = 0.029).
  
  
  CONCLUSIONS
  The expression of Ki-67 and p53 are significantly related to early postoperative recurrence within 1 year after surgical resection in pancreatic head cancer. Especially, Ki-67 was the independent predictive factor for postoperative recurrence within 1 year. Therefore, immunohistochemical staining for Ki-67 and p53 may be applied as a predictive marker for early postoperative recurrence in pancreatic head cancer.
authors.affiliation: Department of Trauma Surgery, Pusan National University Hospital, Busan, Korea.
authors.forename: Hohyun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Trauma Surgery, Pusan National University Hospital, Busan, Korea.
authors.forename: Chan Yong
authors.initials: CY
authors.lastname: Park
authors.affiliation: Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jae Hyuk
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Jung Chul
authors.initials: JC
authors.lastname: Kim
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Chol-Kyoon
authors.initials: CK
authors.lastname: Cho
authors.affiliation: Department of Surgery, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Hee Jun
authors.initials: HJ
authors.lastname: Kim
keywords: Immunohistochemistry; Ki-67 antigen; Pancreatic ductal carcinoma; Risk factors; Tumor suppressor protein p53
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