title: In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.
abstract: Chronic traumatic encephalopathy (CTE) is an acquired primary tauopathy with a variety of cognitive, behavioral, and motor symptoms linked to cumulative brain damage sustained from single, episodic, or repetitive traumatic brain injury (TBI). No definitive clinical diagnosis for this condition exists. In this work, we used [F-18]FDDNP PET to detect brain patterns of neuropathology distribution in retired professional American football players with suspected CTE (n = 14) and compared results with those of cognitively intact controls (n = 28) and patients with Alzheimer's dementia (AD) (n = 24), a disease that has been cognitively associated with CTE. [F-18]FDDNP PET imaging results in the retired players suggested the presence of neuropathological patterns consistent with models of concussion wherein brainstem white matter tracts undergo early axonal damage and cumulative axonal injuries along subcortical, limbic, and cortical brain circuitries supporting mood, emotions, and behavior. This deposition pattern is distinctively different from the progressive pattern of neuropathology [paired helical filament (PHF)-tau and amyloid-β] in AD, which typically begins in the medial temporal lobe progressing along the cortical default mode network, with no or minimal involvement of subcortical structures. This particular [F-18]FDDNP PET imaging pattern in cases of suspected CTE also is primarily consistent with PHF-tau distribution observed at autopsy in subjects with a history of mild TBI and autopsy-confirmed diagnosis of CTE.
authors.affiliation: Departments of Molecular and Medical Pharmacology, jbarrio@mednet.ucla.edu vkepe@mednet.ucla.edu.
authors.forename: Jorge R
authors.initials: JR
authors.lastname: Barrio
authors.affiliation: Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, and.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.affiliation: Departments of Molecular and Medical Pharmacology.
authors.forename: Koon-Pong
authors.initials: KP
authors.lastname: Wong
authors.affiliation: Departments of Molecular and Medical Pharmacology.
authors.forename: Sung-Cheng
authors.initials: SC
authors.lastname: Huang
authors.affiliation: Departments of Molecular and Medical Pharmacology.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Psychiatry and Biobehavioral Sciences and the Semel Institute for Neuroscience and Human Behavior, and.
authors.forename: David A
authors.initials: DA
authors.lastname: Merrill
authors.affiliation: Neurosurgery and Pediatrics, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095;
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Giza
authors.affiliation: Fitzsimmons Law Offices, Wheeling, WV 26003;
authors.forename: Robert P
authors.initials: RP
authors.lastname: Fitzsimmons
authors.affiliation: Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817; and.
authors.forename: Bennet
authors.initials: B
authors.lastname: Omalu
authors.affiliation: Department of Neurosurgery, NorthShore University Health System and University of Chicago Pritzker School of Medicine, Evanston, IL 60201.
authors.forename: Julian
authors.initials: J
authors.lastname: Bailes
authors.affiliation: Departments of Molecular and Medical Pharmacology, jbarrio@mednet.ucla.edu vkepe@mednet.ucla.edu.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kepe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000679:Amygdala / Q000382:microbiology / Q000473:pathology; D001344:Autopsy; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D020208:Brain Injury, Chronic / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D003710:Demography; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000382:microbiology / Q000473:pathology; D008875:Middle Aged; D009570:Nitriles; D049268:Positron-Emission Tomography
chemical_list: C444520:2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrile; D009570:Nitriles
keywords: [F-18]FDDNP PET; chronic traumatic encephalopathy; concussions; tau imaging; traumatic brain injury
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