title: Multiorgan dysfunction syndrome secondary to joint supplement overdosage in a dog.
abstract: A 5-year-old spayed female Bernese mountain dog, with a chief complaint of vomiting and melena ingested approximately 200 nutritional joint supplement tablets. Despite aggressive therapy, the patient developed a coagulopathy, pancreatitis, peritonitis, acute kidney injury, and was euthanized. Postmortem examination revealed myocardial necrosis, pneumonia, centrilobular hemorrhage and necrosis of the liver, vasculitis, and acute tubular necrosis.
authors.affiliation: BluePearl Veterinary Partners - ER/CC, 3000 Busch Lake Blvd, Tampa, Florida 33614, USA (Nobles); ASPCA - Animal Poison Control Center, Urbana, Illinois, USA (Khan).
authors.forename: Irma J
authors.initials: IJ
authors.lastname: Nobles
authors.affiliation: BluePearl Veterinary Partners - ER/CC, 3000 Busch Lake Blvd, Tampa, Florida 33614, USA (Nobles); ASPCA - Animal Poison Control Center, Urbana, Illinois, USA (Khan).
authors.forename: Safdar
authors.initials: S
authors.lastname: Khan
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000662:veterinary; D002809:Chondroitin Sulfates / Q000009:adverse effects / Q000633:toxicity*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D062787:Drug Overdose; D005260:Female; D005944:Glucosamine / Q000009:adverse effects / Q000633:toxicity*; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D002809:Chondroitin Sulfates; D005944:Glucosamine
references.citation: Toxicol Pathol. 1997 Jul-Aug;25(4):344-50
references.pmid: 9280117
references.citation: BMJ Case Rep. 2012;2012. pii: bcr2012007665. doi: 10.1136/bcr-2012-007665
references.pmid: 23239775
references.citation: Vet Clin North Am Small Anim Pract. 2004 Jan;34(1):7-38
references.pmid: 15032124
references.citation: Food Chem Toxicol. 2005 Feb;43(2):187-201
references.pmid: 15621331
references.citation: BMJ Case Rep. 2009;2009:null
references.pmid: 21887162
references.citation: J Am Vet Med Assoc. 2001 Jun 1;218(11):1755-60
references.pmid: 11394823
references.citation: Free Radic Biol Med. 1995 Aug;19(2):227-50
references.pmid: 7649494
references.citation: J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):501-6
references.pmid: 19821894
references.citation: J Am Vet Med Assoc. 2009 Jun 1;234(11):1393-7
references.pmid: 19480618
references.citation: Regul Toxicol Pharmacol. 2007 Feb;47(1):78-83
references.pmid: 16942821
references.citation: J Anim Physiol Anim Nutr (Berl). 2004 Apr;88(3-4):150-6
references.pmid: 15059240
references.citation: World J Gastroenterol. 2013 Aug 28;19(32):5381-4
references.pmid: 23983444
references.citation: Food Chem Toxicol. 2002 Oct;40(10):1459-62
references.pmid: 12387309
references.citation: J Am Vet Med Assoc. 2010 Mar 1;236(5):509-10
references.pmid: 20344826
references.citation: Am J Physiol Regul Integr Comp Physiol. 2003 Oct;285(4):R762-9
references.pmid: 12959920