title: Mesoscopic and macroscopic optoacoustic imaging of cancer.
abstract: Optoacoustic imaging combines the rich contrast of optical methods with the resolution of ultrasound imaging. It can therefore deliver optical visualization of cancer far deeper in tissue than optical microscopy and other conventional optical imaging methods. Technological progress and novel contrast media have resulted in optoacoustic imaging being propagated to basic cancer research and in clinical translation projects. We briefly review recent technological advances, showcase the ability to resolve unique cancer biomarkers based on spectral features at different imaging scales, and highlight the imaging performance achieved in preclinical and clinical imaging applications. .
authors.affiliation: Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany. v.ntziachristos@tum.de.
authors.forename: Adrian
authors.initials: A
authors.lastname: Taruttis
authors.affiliation: Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
authors.forename: Gooitzen M
authors.initials: GM
authors.lastname: van Dam
authors.affiliation: Institute for Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany. Chair for Biological Imaging, Technische Universität München, Munich, Germany.
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D061088:Photoacoustic Techniques / Q000379:methods*; D012680:Sensitivity and Specificity; D014465:Ultrasonics / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D003287:Contrast Media