title: Reducing β-amyloid by inhibition of BACE1: how low should you go?
authors.affiliation: Institute of Psychiatry, Psychology & Neuroscience, King's College London.
authors.forename: Richard
authors.initials: R
authors.lastname: Killick
authors.affiliation: Reta Lilla Weston Research Laboratories, University College London (UCL) Institute of Neurology. Electronic address: j.hardy@ucl.ac.uk.
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, University College London, London, United Kingdom.
authors.forename: J Paul
authors.initials: JP
authors.lastname: Simons
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000172:deficiency*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000172:deficiency*; D001921:Brain / Q000378:metabolism*; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000378:metabolism*; D049229:Dendritic Spines / Q000378:metabolism*; D006801:Humans; D055366:Synaptic Potentials / Q000502:physiology*
chemical_list: D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases