title: Dystrophic-Anagen Effluvium Occurring During Pegylated Interferon-α-2a/Ribavirin Therapy.
abstract: BACKGROUND
  Various types of dermatological manifestations have been reported due to hepatitis C virus (HCV) infection and anti-HCV therapy. Some of them have been described during IFN-based therapies. PEG-IFN-α-2a/RBV combination is used as the international standard of treatment for HCV infection for a long time. The combination therapy yields an adverse-event profile similar to standard interferon (IFN) therapy. Some of these adverse effects are rheumatologic, neuropsychiatric and dermatological manifestations including alopecia.
  
  
  METHODS
  We reported a 43-year-old woman with dystrophic anagen effluvium (DAE), rheumatoid arthritis and Hashimoto thyroiditis, which were developed under the combination therapy for chronic HCV infection.
  
  
  CONCLUSIONS
  Although some cases of alopecia areata (AA) and telogen effluvium (TE) were reported in literature, no case of DAE associated with PEG-INF-α-2a /RBV combination therapy was reported previously.
authors.affiliation: Department of Infectious Diseases, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Turker
authors.affiliation: Department of Dermatology, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Tas
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ozkaya
authors.affiliation: Department of Gastroenterology, Dumlupinar University Faculty of Medicine, Evliya Celebi Research and Training Hospital, Kutahya, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Tas
authors.affiliation: Department of Pathology, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
authors.forename: Aysel
authors.initials: A
authors.lastname: Caglar
authors.affiliation: Department of Pathology, Ministry of Health Bagcilar State Hospital, Istanbul, Turkey.
authors.forename: Umit Seza
authors.initials: US
authors.lastname: Tetikkurt
keywords: Alopecia; Chronic Hepatitis C; Interferon; Therapy
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