title: 3-Hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use.
abstract: Although iron is one of the most important metal ions for living organisms, it becomes toxic when in excess or misplaced. This review presents a glance at representative examples of hydroxypyridinone-based chelators, which have been recently developed as potential clinically useful drugs for metal overload diseases, mostly associated with excess of iron but also other hard metal-ions. It also includes a detailed discussion on the factors assisting chelator design strategy toward fulfillment of the most relevant biochemical properties of hydroxypyridinone chelators, highlighting structure-activity relationships and a variety of potential clinical applications, beyond chelatotherapy. This study appears as a response to the growing interest on metal chelation therapy and opens new perspectives of possible applications in future medicine.
authors.affiliation: Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: M Amélia
authors.initials: MA
authors.lastname: Santos
authors.forename: Sílvia
authors.initials: S
authors.lastname: Chaves
mesh_terms: D000818:Animals; D015913:Chelation Therapy; D006801:Humans; D007502:Iron Chelating Agents / Q000737:chemistry* / Q000627:therapeutic use*; D019190:Iron Overload / Q000188:drug therapy*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: C121031:3-hydroxypyridin-4-one; D007502:Iron Chelating Agents; D011725:Pyridines