title: A bioelectronic system for insulin release triggered by ketone body mimicking diabetic ketoacidosis in vitro.
abstract: A bioelectronic system composed of two modified electrodes, one activated in the presence of ketone bodies, a biomarker of diabetic ketoacidosis, and another releasing insulin upon receiving a signal, was designed and tested in vitro to operate as a Sense-and-Act device. The functional integration of biomarker-sensing and insulin-releasing electrodes represents a step to a theranostic system with autonomous operation.
authors.affiliation: Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699-5810, USA. ekatz@clarkson.edu.
authors.forename: Maria
authors.initials: M
authors.lastname: Gamella
authors.forename: Nataliia
authors.initials: N
authors.lastname: Guz
authors.forename: José M
authors.initials: JM
authors.lastname: Pingarrón
authors.forename: Roshanak
authors.initials: R
authors.lastname: Aslebagh
authors.forename: Costel C
authors.initials: CC
authors.lastname: Darie
authors.forename: Evgeny
authors.initials: E
authors.lastname: Katz
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D015374:Biosensing Techniques; D016883:Diabetic Ketoacidosis / Q000378:metabolism*; D004566:Electrodes; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007657:Ketone Bodies / Q000032:analysis* / Q000378:metabolism*; D008958:Models, Molecular
chemical_list: D015415:Biomarkers; D007328:Insulin; D007657:Ketone Bodies