title: Inverse association of serum vitamin D in relation to carotid intima-media thickness in Chinese postmenopausal women.
abstract: OBJECTIVE
  This study aimed to investigate the relationship between serum vitamin D level and carotid intima-media thickness (C-IMT) in Chinese postmenopausal women.
  
  
  METHODS
  Nine hundred and twenty six Chinese postmenopausal women without carotid artery plaque or history of cardiovascular disease were selected for analysis. Measurements of serum 25 hydroxyvitamin D3 (25(OH)D3) concentration and C-IMT were made by electrochemiluminescence immunoassay and B-mode ultrasound, respectively. Trend analysis was conducted according to tertiles of C-IMT.
  
  
  RESULTS
  The median serum 25(OH)D3 level was 11.03 ng/mL, with an interquartile range of 8.22-14.70. A decreasing trend of serum 25(OH)D3 level was accompanied by increased C-IMT tertiles (P for trend = 0.001). Correlation analysis found an inverse relationship between serum 25(OH)D3 level and C-IMT (r = -0.113, P = 0.001). After adjustment for confounding factors, multiple regression analysis showed that serum 25(OH)D3 level independently and negatively associated with C-IMT (Standard β = -0.112, P < 0.001). Moreover, the inverse correlation of serum 25(OH)D3 with C-IMT was also found in a subgroup of women with normal glucose tolerance, blood pressure and body mass index, and without undergoing lipid-lowering therapy (standard β = -0.140, P = 0.018).
  
  
  CONCLUSIONS
  Serum 25(OH)D3 level was inversely correlated with C-IMT in Chinese postmenopausal women.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Xiong
authors.affiliation: Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China.
authors.forename: Jiaan
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Yuqian
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
mesh_terms: D000368:Aged; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood* / Q000502:physiology*; D017539:Tunica Intima / Q000502:physiology*; D014807:Vitamin D / Q000097:blood
chemical_list: D014807:Vitamin D; D002112:Calcifediol
references.citation: Am J Clin Nutr. 2013 Mar;97(3):524-30
references.pmid: 23364011
references.citation: Ann Intern Med. 2001 Dec 4;135(11):939-53
references.pmid: 11730394
references.citation: Eur J Endocrinol. 2012 Oct;167(4):553-60
references.pmid: 22875588
references.citation: JAMA. 1999 Oct 6;282(13):1247-53
references.pmid: 10517427
references.citation: Transplant Proc. 2012 Nov;44(9):2588-9
references.pmid: 23146463
references.citation: J Am Coll Cardiol. 2008 Dec 9;52(24):1949-56
references.pmid: 19055985
references.citation: Diabetes. 2010 Jan;59(1):242-8
references.pmid: 19833894
references.citation: Ann Nutr Metab. 2007;51(1):59-64
references.pmid: 17356256
references.citation: J Clin Invest. 2002 Jul;110(2):229-38
references.pmid: 12122115
references.citation: World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253
references.pmid: 11234459
references.citation: Menopause. 2013 Nov;20(11):1194-9
references.pmid: 23571521
references.citation: Arterioscler Thromb. 1994 May;14(5):840-56
references.pmid: 8172861
references.citation: Circulation. 2011 Feb 1;123(4):e18-e209
references.pmid: 21160056
references.citation: J Womens Health (Larchmt). 2011 Sep;20(9):1341-8
references.pmid: 21732811
references.citation: J Clin Endocrinol Metab. 2013 Jan;98(1):345-51
references.pmid: 23162093
references.citation: Diabetes Metab Syndr Obes. 2011 Jan 19;4:23-34
references.pmid: 21448319
references.citation: J Clin Endocrinol Metab. 2005 Feb;90(2):635-40
references.pmid: 15546897
references.citation: Atherosclerosis. 2012 Aug;223(2):437-41
references.pmid: 22632919
references.citation: Circulation. 1993 Mar;87(3 Suppl):II56-65
references.pmid: 8443925
references.citation: Arch Intern Med. 2007 Jun 11;167(11):1159-65
references.pmid: 17563024
references.citation: Circulation. 2009 Aug 25;120(8):687-98
references.pmid: 19667238
references.citation: N Engl J Med. 1987 Apr 30;316(18):1105-10
references.pmid: 3574358
references.citation: Zhonghua Xin Xue Guan Bing Za Zhi. 2007 May;35(5):390-419
references.pmid: 17711682
references.citation: Curr Med Res Opin. 2008 Jan;24(1):99-106
references.pmid: 18028585
references.citation: Med Sci Sports Exerc. 2003 Aug;35(8):1381-95
references.pmid: 12900694
references.citation: Curr Med Res Opin. 2007 Aug;23(8):1939-44
references.pmid: 17631697
references.citation: Kidney Int. 2013 Jul;84(1):54-63
references.pmid: 23423254
references.citation: Eur J Endocrinol. 2013 Dec;169(6):767-72
references.pmid: 24005315
references.citation: Clin Endocrinol (Oxf). 2006 Nov;65(5):593-7
references.pmid: 17054459
references.citation: Int J Obes (Lond). 2012 Sep;36(9):1203-8
references.pmid: 22124446