title: Postnatal treadmill exercise attenuates prenatal stress-induced apoptosis through enhancing serotonin expression in aged-offspring rats.
abstract: Maternal stress during pregnancy affects negative impact on health of offspring. In the present study, we compared the effects of maternal treadmill exercise and offspring treadmill exercise on prenatal stress-induced apoptosis and serotonin expression in offspring. Stress to the pregnant rats was induced by exposure of maternal rats to the hunting dog in an enclosed room. Exposure time was 10 min, three times per day, with a 1-h interval between exposures. This regimen was maintained from the seventh day of gestation until delivery. The pregnant rats in the exercise group were forced to run on a motorized tread-mill for 30 min once a day, started 7 days after pregnancy until delivery. The offspring in the exercise group were forced to run on a motorized treadmill for 30 min once a day, started 4 weeks after birth for 4 weeks. In the present results, offspring exposed to prenatal stress exhibited lower Bcl-2 level and higher Bax level in the hippocampus, lower 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) expression in the dorsal raphe, and higher c-Fos expression in the locus coeruleus compared to age-matched control rats. Treadmill exercise of offspring suppressed Bax expression and enhanced Bcl-2 expression in the hippocampus, increased 5-HT and TPH expression in the dorsal raphe, and enhanced c-Fos expression in the locus coeruleus of offspring. Tread-mill exercise of offspring suppressed prenatal stress-induced apoptosis and normalized prenatal stress-induced alterations in serotonin synthesis and neuronal activation. However maternal treadmill exercise during pregnancy exerted no significant effect on offspring.
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Tae-Woon
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Eun-Sang
authors.initials: ES
authors.lastname: Ji
authors.affiliation: Department of Community Sport and Recreation, College of Health Science, Jangan University, Hwasung, Korea.
authors.forename: Tae-Wook
authors.initials: TW
authors.lastname: Kim
authors.affiliation: Department of Physical Education, Korea Military Academy, Seoul, Korea.
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Oriental Physiology, Gachon University College of Oriental Medicine, Seongnam, Korea.
authors.forename: Choong-Yeol
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Physical Education, College of Health, Welfare, and Education, Tong Myong University, Busan, Korea.
authors.forename: Sam-Jun
authors.initials: SJ
authors.lastname: Lee
keywords: Apoptosis; Offspring; Prenatal stress; Rats; Treadmill exercise
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