title: A new protocol for nickel-catalysed regio- and stereoselective hydrocyanation of allenes.
abstract: Regio- and stereoselective hydrocyanation under nickel catalysis is described. This report shows that allenyl C-C double bonds are discriminated and converted to the corresponding carbonitriles as a single product. The key functionalities for achieving high regio- and stereocontrol are aryl and cyclopropyl groups in the substrates.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan. araisgr@chiba-u.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Arai
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hori
authors.forename: Yuka
authors.initials: Y
authors.lastname: Amako
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nishida
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003485:Cyanates / Q000737:chemistry; D003500:Cyclization; D003521:Cyclopropanes / Q000737:chemistry; D009532:Nickel / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D003485:Cyanates; D003521:Cyclopropanes; D009570:Nitriles; D009532:Nickel; C030797:cyclopropane