title: Autophagy in tumorigenesis and cancer treatment.
abstract: Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles for degradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Here we overview articles on autophagy and cancer/tumors in Pubmed and found 327 articles. Autophagy exists in many tumors and is involved in cell malignant transformation and tumor cell growth. In early phases of tumorigenesis, autophagy clears the abnormally folded proteins and dysfunctional organelles such as mitochondria. Autophagy can also inhibit cell stress responses and prevent genetic damage. When a tumor develops, autophagy helps tumor cells survive nutritional deficiencies and hypoxic conditions. Studies of autophagy in the occurrence and progression of tumors should provide new therapeutic strategies for tumors.
authors.affiliation: Department of Chinese Minority Traditional Medicine, Minzu University of China, Beijing, China E-mail : xxu@bwh.harvard.edu, tongxliu123@hotmail.com.
authors.forename: Dong-Wei
authors.initials: DW
authors.lastname: Xu
authors.forename: Guan-Qing
authors.initials: GQ
authors.lastname: Zhang
authors.forename: Zong-Wei
authors.initials: ZW
authors.lastname: Wang
authors.forename: Xiao-Yin
authors.initials: XY
authors.lastname: Xu
authors.forename: Tong-Xiang
authors.initials: TX
authors.lastname: Liu
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001343:Autophagy; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D016588:Anticarcinogenic Agents