title: Genetic and immunologic susceptibility to statin-related myopathy.
abstract: Statin-related myopathy (SRM) undermines drug adherence that is critical for achieving the benefits of lipid-lowering therapy. While the exact mechanism of SRM remains largely unknown, recent evidence supports specific genetic and immunologic influence on the development of intolerance. Genes of interest include those involved in the pharmacokinetics of statin response (i.e. drug metabolism, uptake transporters, and efflux transporters), pharmacodynamics (i.e. drug toxicity and immune-mediated myopathy), and gene expression. We examine the influence of genetic and immunologic variation on the pharmacokinetics, pharmacodynamics, and gene expression of SRM.
authors.affiliation: Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA; Medical College of Virginia-Virginia Commonwealth University Medical Center, Richmond, VA, USA. Electronic address: jaideepatel@hotmail.com.
authors.forename: Jaideep
authors.initials: J
authors.lastname: Patel
authors.affiliation: Mercer University School of Pharmaceutical Sciences, Atlanta, GA, USA; Cholesterol, Genetics, and Heart Disease Institute, Portola Valley, CA, USA.
authors.forename: H Robert
authors.initials: HR
authors.lastname: Superko
authors.affiliation: Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
authors.forename: Seth S
authors.initials: SS
authors.lastname: Martin
authors.affiliation: Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA.
authors.forename: Roger S
authors.initials: RS
authors.lastname: Blumenthal
authors.affiliation: Johns Hopkins Myositis Center, Baltimore, MD, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Christopher-Stine
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000493:pharmacokinetics; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010597:Pharmacogenetics; D010641:Phenotype; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Anti-HMGCR; Pharmacogenomics; SLCO1B1; Statin-related myopathy