title: Connectivity Study of the Neuromechanism of Acute Acupuncture Needling during fMRI in "Overweight" Subjects.
abstract: This functional connectivity study depicts how acupoints ST 36 and SP 9 and their sham acupoints acutely act on blood glucose (GLU), core body temperature (CBT), hunger, and sensations pertaining to needling (De-qi) via the limbic system and dopamine (DA) to affect various brain areas in fasting, adult, and "overweight" Chinese males using functional magnetic resonance imaging. Functional connectivity (FC) analysis utilized the amygdala (AMY) and hypothalamus (HYP) as regions of interest (ROIs) in the discrete cosine transform and seed correlation analysis methods. There was a significant difference in the spatial patterns of the distinct brain regions between groups. Correlation results showed that increased HYP-hippocampus FC after ACU was positively correlated with ACU-induced change in CBT; increased HYP-putamen-insula FC after ACU was positively correlated with ACU-induced change in GLU; and increased HYP-anterior cingulate cortex FC after ACU was positively correlated with ACU-induced change in HUNGER suggesting that increased DA modulation during ACU was probably associated with increased poststimulation limbic system and spinothalamic tract connectivity. Decreased HYP-thalamus FC after ACU was negatively correlated or anticorrelated with ACU-induced change in HUNGER suggesting that increased DA modulation during ACU was possibly associated with decreased poststimulation limbic system and spinothalamic tract connectivity. No correlation was found for min SHAM. This was an important study in addressing acute acupuncture effects and neural pathways involving physiology and appetite regulation in overweight individuals.
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China ; Department of Psychiatry & McKnight Brain Institute, University of Florida, 1149 S. Newell Dr. L4-100K, Gainesville, FL 32610, USA.
authors.forename: Karen M
authors.identifier: 0000-0002-5310-1003
authors.initials: KM
authors.lastname: von Deneen
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Minghao
authors.identifier: 0000-0002-0190-6985
authors.initials: M
authors.lastname: Dong
authors.affiliation: Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, P.O. Box 100126 2015 SW 16th Avenue, Gainesville, FL 32610, USA.
authors.forename: Huisheng
authors.initials: H
authors.lastname: Xie
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Yi
authors.identifier: 0000-0003-0859-9735
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry & McKnight Brain Institute, University of Florida, 1149 S. Newell Dr. L4-100K, Gainesville, FL 32610, USA.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Gold
authors.affiliation: Department of Psychiatry & McKnight Brain Institute, University of Florida, 1149 S. Newell Dr. L4-100K, Gainesville, FL 32610, USA.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Life Science and Technology, Xidian University, Xi'an 710071, China.
authors.forename: Jie
authors.identifier: 0000-0003-0498-0432
authors.initials: J
authors.lastname: Tian
references.citation: Zhonghua Liu Xing Bing Xue Za Zhi. 2004 Dec;25(12):1035-8
references.pmid: 15769358
references.citation: Acupunct Med. 2013 Mar;31(1):88-97
references.pmid: 23153472
references.citation: Neurosci Biobehav Rev. 2002 Jun;26(4):393-428
references.pmid: 12204189
references.citation: Int J Neurosci. 2006 Feb;116(2):165-75
references.pmid: 16393882
references.citation: J Magn Reson Imaging. 2009 Jul;30(1):41-6
references.pmid: 19557845
references.citation: Hum Brain Mapp. 2005 Mar;24(3):193-205
references.pmid: 15499576
references.citation: Brain Res. 2006 Oct 9;1114(1):138-48
references.pmid: 16919246
references.citation: Neuroimage. 2005 Sep;27(3):479-96
references.pmid: 16046146
references.citation: Endocrinology. 2002 Nov;143(11):4409-21
references.pmid: 12399438
references.citation: Hum Brain Mapp. 2005 Sep;26(1):15-29
references.pmid: 15852468
references.citation: Endocrinol Metab Clin North Am. 2008 Dec;37(4):811-23
references.pmid: 19026933
references.citation: Radiology. 1999 Jul;212(1):133-41
references.pmid: 10405732
references.citation: J Cereb Blood Flow Metab. 1993 Jan;13(1):5-14
references.pmid: 8417010
references.citation: Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):61-73
references.pmid: 15998351
references.citation: Nutrition. 2000 Oct;16(10):843-57
references.pmid: 11054589
references.citation: Hum Brain Mapp. 2003 Mar;18(3):222-32
references.pmid: 12599281
references.citation: Cell Metab. 2007 Nov;6(5):345-7
references.pmid: 17983579
references.citation: Pain. 2004 Jul;110(1-2):205-14
references.pmid: 15275769
references.citation: Endocrinology. 2002 Feb;143(2):726-9
references.pmid: 11796530
references.citation: Endocr Rev. 1999 Feb;20(1):68-100
references.pmid: 10047974
references.citation: J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):260-2
references.pmid: 15654046
references.citation: Obes Rev. 2012 May;13(5):409-30
references.pmid: 22292480
references.citation: J Altern Complement Med. 2002 Aug;8(4):411-9
references.pmid: 12230901
references.citation: Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E297-304
references.pmid: 15039149
references.citation: J Neurosci. 2001 Jul 15;21(14):5304-10
references.pmid: 11438606
references.citation: Int J Eat Disord. 2006 Jul;39(5):357-63
references.pmid: 16565998
references.citation: Diabetes Technol Ther. 2001 Winter;3(4):617-22
references.pmid: 11911174
references.citation: J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):615-9
references.pmid: 17158560
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: J Addict Dis. 2004;23(3):5-21
references.pmid: 15256341
references.citation: Int J Obes (Lond). 2009 Jun;33(6):653-61
references.pmid: 19365394
references.citation: Neuroreport. 2004 Aug 26;15(12):1937-40
references.pmid: 15305141
references.citation: Brain Res. 2009 Jul 7;1279:37-49
references.pmid: 19427842
references.citation: Mol Pain. 2010 Nov 02;6:73
references.pmid: 21044291
references.citation: J Addict Dis. 2004;23(3):23-37
references.pmid: 15256342
references.citation: Trends Pharmacol Sci. 2001 Jan;22(1):46-7
references.pmid: 11165672
references.citation: Nature. 2006 Sep 21;443(7109):289-95
references.pmid: 16988703
references.citation: Mol Pain. 2008 Nov 13;4:55
references.pmid: 19014532
references.citation: Brain Res. 1999 Nov 27;848(1-2):114-23
references.pmid: 10612703
references.citation: Front Neuroendocrinol. 1996 Oct;17(4):371-401
references.pmid: 8905347
references.citation: J Neurocytol. 2002 Mar-Jun;31(3-5):373-85
references.pmid: 12815254
references.citation: Physiol Behav. 2005 Dec 15;86(5):773-95
references.pmid: 16289609
references.citation: Neurosci Biobehav Rev. 1997 May;21(3):341-59
references.pmid: 9168269
references.citation: Regul Pept. 2003 Mar 28;111(1-3):1-11
references.pmid: 12609743
references.citation: Front Neuroendocrinol. 2000 Jul;21(3):263-307
references.pmid: 10882542
references.citation: Mol Endocrinol. 2008 May;22(5):1023-31
references.pmid: 18202144
references.citation: Neuroimage. 2004 Jun;22(2):932-40
references.pmid: 15193624