title: Serum sLOX-1 Levels Are Correlated with the Presence and Severity of Obstructive Sleep Apnea.
abstract: BACKGROUND
  Inflammation plays a critical role in the development and progression of obstructive sleep apnea (OSA). Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) activation is involved in the pathophysiology of inflammatory process-related disorders.
  
  
  OBJECTIVE
  This study aims to investigate whether serum soluble LOX-1 (sLOX-1) levels are associated with the presence and severity of OSA.
  
  
  METHODS
  A total of 137 OSA patients and 78 controls were recruited in this study. Serum sLOX-1 levels were measured by enzyme-linked immunosorbent assay. The severity of OSA was assessed by the apnea-hypopnea index (AHI).
  
  
  RESULTS
  OSA patients had significantly higher serum sLOX-1 levels compared with controls. Serum sLOX-1 levels elevated with the increment of OSA severity. sLOX-1 was the independent predictor of OSA. Serum sLOX-1 levels were significantly correlated with AHI and high-sensitivity C-reactive protein levels.
  
  
  CONCLUSIONS
  Serum sLOX-1 levels were independently correlated with the presence and severity of OSA. These findings revealed that sLOX-1 might function as a potential biomarker for monitoring the development and progression of OSA.
authors.affiliation: 1 Department of Stomatology, Yiwu Central Hospital , Yiwu, People's Republic of China .
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Xu
authors.forename: Da-Ju
authors.initials: DJ
authors.lastname: Li
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Wu
authors.forename: Han-Jian
authors.initials: HJ
authors.lastname: Lou
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Jiang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Ding
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D008875:Middle Aged; D051127:Scavenger Receptors, Class E / Q000097:blood*; D012891:Sleep Apnea Syndromes / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood*
chemical_list: D015415:Biomarkers; C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; D002097:C-Reactive Protein
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