title: Biological properties of nanostructured Ti incorporated with Ca, P and Ag by electrochemical method.
abstract: TiO2 nanotube arrays were synthesized on Ti surface by anodic oxidation. The elements of Ca and P were simultaneously incorporated during nanotubes growth in SBF electrolyte, and then Ag was introduced to nanotube arrays by cathodic deposition, which endowed the good osseointegration and antibacterial property of Ti. The bioactivity of the Ti surface was evaluated by simulated body fluid soaking test. The biocompatibility was investigated by in vitro cell culture test. And the antibacterial effect against Staphylococcus aureus was examined by the bacterial counting method. The results showed that the incorporation of Ca, P and Ag elements had no significant influence on the formation of nanotube arrays on Ti surface during electrochemical treatment. Compared to the polished or nanotubular Ti surface, TiO2 nanotube arrays incorporated with Ca, P and Ag increased the formation of bone-like apatite in simulated body fluid, enhanced cell adhesion and proliferation, and inhibited the bacterial growth. Based on these results, it can be concluded that the nanostructured Ti incorporated with Ca, P and Ag by electrochemical method has promising applications as implant material.
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China.
authors.forename: Baoe
authors.initials: B
authors.lastname: Li
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China.
authors.forename: Jingzu
authors.initials: J
authors.lastname: Hao
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Min
authors.affiliation: Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Shigang
authors.initials: S
authors.lastname: Xin
authors.affiliation: School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou 221116, PR China.
authors.forename: Litong
authors.initials: L
authors.lastname: Guo
authors.affiliation: National Key Laboratory of C1 Chemical Industry, Tianjin University, Tianjin 300072, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China.
authors.forename: Chunyong
authors.initials: C
authors.lastname: Liang
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China.
authors.forename: Hongshui
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300130, PR China. Electronic address: lhpcx@163.com.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000494:pharmacology*; D004595:Electroplating / Q000379:methods; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology*; D010316:Particle Size; D010758:Phosphorus / Q000737:chemistry / Q000494:pharmacology; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; C009495:titanium dioxide; D010758:Phosphorus; D012834:Silver; D014025:Titanium; D002118:Calcium
keywords: Antibacterial property; Bioactivity; Biocompatibility; Electrochemical method; Titanium