title: Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements.
abstract: An association between postoperative analgesic requirements in subjects who underwent orthognathic surgery and the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene was suggested by our previous genome-wide association study. To verify this association, we analyzed the association between the rs1465040 SNP and analgesic requirements, including opioid requirements, after open abdominal surgery. The association between the rs1465040 SNP and postoperative analgesic requirements was confirmed in the open abdominal surgery group (P = 0.036), suggesting that the TRPC3 SNP may contribute to predicting postoperative analgesic requirements.
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Aoki
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishizawa
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Hasegawa
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kasai
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Yoshida
authors.affiliation: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koukita
authors.affiliation: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ichinohe
authors.affiliation: Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nagashima
authors.affiliation: Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
authors.forename: Ryoji
authors.initials: R
authors.lastname: Katoh
authors.affiliation: Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Satoh
authors.affiliation: Department of Anesthesiology, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba 285-8741, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Tagami
authors.affiliation: Department of Anesthesiology, Juntendo University, 3-1-3 Hongou, Bunkyo-ku, Tokyo 113-8431, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hayashida
authors.affiliation: Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Fukuda
authors.affiliation: Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan. Electronic address: ikeda-kz@igakuken.or.jp.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D005260:Female; D005544:Forecasting; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures; D010149:Postoperative Pain / Q000188:drug therapy* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011182:Postoperative Care; D050052:TRPC Cation Channels / Q000235:genetics*; D055815:Young Adult
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D050052:TRPC Cation Channels; C104603:TRPC3 cation channel
keywords: Analgesics; Polymorphism; TRPC3