title: [Histoplasmosis: the multiple sides of an uncommon disease].
abstract: Disseminated histoplasmosis is an invasive fungal infection documented in patients with impaired cellular immunity coming from endemic areas (America, Asia, Africa). We report two cases of disseminated histoplasmosis in AIDS patients paradigmatic of the multifaceted nature of the disease, which may be an expression either of an advanced state of immunosuppression or the immune reconstitution inflammatory syndrome (IRIS).
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Amadori
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Doria
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Gemignani
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Sarah
authors.initials: S
authors.lastname: Flammini
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Leonildi
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Eugenio Mario
authors.initials: EM
authors.lastname: Ciancia
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.affiliation: Unita Operativa di Malattie Infettive, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Unita Operativa di Anatomia Patologica Seconda, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Laboratorio di Microbiologia, Universita Cattolica del Sacro Cuore, Policlinico A. Gemelli, Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Menichetti
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001938:Brazil; D003840:Deoxycholic Acid / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004338:Drug Combinations; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications; D019701:Hepatitis D, Chronic / Q000150:complications; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018451:Homosexuality, Male; D006801:Humans; D016867:Immunocompromised Host; D000072742:Invasive Fungal Infections; D007558:Italy; D008297:Male; D012307:Risk Factors; D013785:Thailand; D016896:Treatment Outcome; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination; D065819:Voriconazole