title: Experimental modulation and computational model of nano-hydrophobicity.
abstract: We demonstrate that nano-hydrophobicity, which governs the biological aggressiveness of nanoparticles, is determined by the outermost regions of surface ligands. We have also successfully modulated nano-hydrophobicity using systematic surface ligand modifications and built the first computational model of nano-hydrophobicity.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Shuhuan
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhai
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Jinmei
authors.initials: J
authors.lastname: Wu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiao
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, Rutgers University, Camden, NJ, United States; The Rutgers Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, China. Electronic address: drbingyan@yahoo.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D002851:Chromatography, High Pressure Liquid; D003198:Computer Simulation; D006046:Gold / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D008027:Light; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods*; D012542:Scattering, Radiation; D013499:Surface Properties
chemical_list: D008024:Ligands; D006046:Gold
keywords: Cytotoxicity; Gold; Hydrophilicity/hydrophobicity; Macrophages; Nanoparticle; Transmission electron microscopy (TEM)
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