title: Pediatric systemic lupus erythematosus presenting with coronary arteritis: A case series and review of the literature.
abstract: OBJECTIVE
  Pediatric-onset systemic lupus erythematosus (pSLE) is typically more aggressive in presentation than adult-onset lupus. Presenting manifestations of lupus in children and adults involve similar organ systems, with renal and neuropsychiatric involvement more common in pSLE. Cardiac manifestations are similar in the 2 groups, with pericarditis accounting for the majority of cardiac lupus at presentation. There are no reports to our knowledge of coronary arteritis as a presenting feature of pSLE.
  
  
  METHODS
  This is a retrospective case series describing 4 pediatric lupus patients who presented with prominent coronary artery dilatation and a review of the literature regarding coronary artery involvement in lupus.
  
  
  RESULTS
  Coronary arteritis appears to be a more common feature of pSLE than previously thought. Based on our experience, coronary artery changes tend to resolve once the SLE is treated.
  
  
  CONCLUSIONS
  Early recognition of this disease manifestation may guide therapy and result in improved long-term cardiovascular outcomes.
authors.affiliation: Children's Hospital Los Angeles, 4650 Sunset Blvd Mailstop 60, Los Angeles, CA 90027. Electronic address: aragarwal@chla.usc.edu.
authors.forename: Arunima
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Stephanie Biglarian
authors.initials: SB
authors.lastname: Medical Student
authors.affiliation: Children's Hospital Los Angeles, 4650 Sunset Blvd Mailstop 60, Los Angeles, CA 90027.
authors.forename: Sophia
authors.initials: S
authors.lastname: Lim-Stavros
authors.affiliation: Children's Hospital Los Angeles, 4650 Sunset Blvd Mailstop 60, Los Angeles, CA 90027; Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Jodie K
authors.initials: JK
authors.lastname: Votava-Smith
authors.affiliation: Children's Hospital Los Angeles, 4650 Sunset Blvd Mailstop 60, Los Angeles, CA 90027; Keck School of Medicine, University of Southern California, Los Angeles, CA.
authors.forename: Anusha
authors.initials: A
authors.lastname: Ramanathan
mesh_terms: D000293:Adolescent; D001167:Arteritis / Q000150:complications*; D002648:Child; D003324:Coronary Artery Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D012189:Retrospective Studies
keywords: Coronary artery; Pediatrics; Systemic lupus erythematosus; Vasculitis