title: Premedication with oral pregabalin for the prevention of acute postsurgical pain in coronary artery bypass surgery.
abstract: BACKGROUND
  For coronary artery bypass grafting (CABG) sternotomy should be performed. The pain after surgery is severe and requires medical intervention. Use of the analgesics is limited by their side effects and studies suggest that prevention with some medications before surgery is effective in controlling the postoperative pain.
  
  
  OBJECTIVE
  We investigated the efficacy of pregabalin administration before surgery in the treatment of acute postoperative pain after CABG surgery.
  
  
  METHODS
  Sixty patients indicated for elective CABG surgery were randomly allocated to two groups. One group received placebo and the other received 150 mg of oral pregabalin before surgery. Heart rates, blood pressure, respiratory rate, intensive care unit (ICU) stay duration, morphine consumption, and pain score according to the visual analog scale (VAS) were measured and recorded at 4, 12, and 24 hours of surgery.
  
  
  RESULTS
  Pregabalin consumption did not alter hemodynamic parameters and was safe in patients after CABG. Its consumption was associated with significant reduction in the pain score (P values were 0.035, 0.026, and 0.047 respectively at 4, 12, and 24 hours of surgery). Its use was not associated with changes in the morphine consumption at 4, 12, and 24 hours of surgery (P > 0.05).
  
  
  CONCLUSIONS
  Premedication with studied dose of pregabalin is effective for the prevention of postoperative pain in patients after CABG and has no adverse effects. Trials with other treating schedule and doses of the drug should be performed to determine the best treatment plan.
authors.affiliation: Department of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Ziyaeifard
authors.affiliation: Department of Cardiac Anesthesia, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Mehrabanian
authors.affiliation: Department of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
authors.forename: Seyedeh Zahra
authors.initials: SZ
authors.lastname: Faritus
authors.affiliation: Department of Cardiac Anesthesia, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, IR Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Khazaei Koohpar
authors.affiliation: Department of Anesthesiology, Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
authors.forename: Rasool
authors.initials: R
authors.lastname: Ferasatkish
authors.affiliation: Department of Anesthesia, Shahrood Branch of Islamic Azad University, Shahrood, Iran.
authors.forename: Heidar
authors.initials: H
authors.lastname: Hosseinnejad
authors.affiliation: Department of Neurosurgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mehrabanian
keywords: Acute Pain; Coronary Artery Bypass; Morphine; Pain Management; Pregabalin
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