title: Paving the path to HIV neurotherapy: Predicting SIV CNS disease.
abstract: HIV-induced damage to the CNS remains a major challenge for over 30 million people in the world despite the successes of combined antiretroviral therapy in limiting viral replication. Predicting development and progression of HIV-associated CNS disease is crucial because prevention and early intervention could be more effective than attempts to promote repair. The SIV/macaque model is the premier platform to study HIV neuropathogenesis, including discovery of predictive factors such as neuroprotective host genes and both blood and CSF biomarkers that precede and predict development of SIV CNS disease. This report details the role of macaque MHC class I genes, longitudinal alterations in biomarkers in the circulation, and expression of inflammatory and neuronal damage markers in CSF using samples from SIV-inoculated pigtailed macaques collected during acute, asymptomatic, and terminal stages of infection.
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Beck
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Queen
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Witwer
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Kelly A
authors.initials: KA
authors.lastname: Metcalf Pate
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Mangus
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Lucio
authors.initials: L
authors.lastname: Gama
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Adams
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: Janice E
authors.initials: JE
authors.lastname: Clements
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
authors.forename: M
authors.initials: M
authors.lastname: Christine Zink
authors.affiliation: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address: jmankows@jhmi.edu.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Mankowski
mesh_terms: D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000821:virology; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D004195:Disease Models, Animal; D006801:Humans; D008254:Macaca nemestrina; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011237:Predictive Value of Tests; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000821:virology; D015302:Simian Immunodeficiency Virus
chemical_list: D015415:Biomarkers; D018696:Neuroprotective Agents
keywords: CCL2; CSF; HIV; IL-6; MHC class I; Pigtailed macaque; Platelets; SIV
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