title: Partial hydatidiform mole with extensive angiomatoid vessel configuration in a first trimester miscarriage.
abstract: We report a first trimester miscarriage (9 wk gestation) with a macroscopic grape-like aspect due to extensive angiomatoid changes with widened communicating thin-walled villous vessels. Fluorescence in situ hybridization analysis and microsatellite analysis revealed a diandric triploidy of the trophoblastic tissue, so this miscarriage is indeed a genetic partial hydatidiform mole. This is remarkable since the typical morphologic hallmarks of partial hydatidiform mole, especially enhanced trophoblastic proliferation and marked villous cistern formation, were not prominent. The finding of extensive angiomatoid morphology is to our knowledge an undescribed morphology of an early partial hydatidiform mole. It serves as an example of the morphologic variability of this probably underestimated condition that has a slightly elevated risk for the development of gestational trophoblastic disease.
authors.affiliation: Institute of Pathology (H.F.) Department of Obstetrics and Gynecology (J.O.), Diakonissenkrankenhaus Flensburg, Flensburg Department of Human Genetics (A.C.), University of Kiel, Kiel Institute of Pathology of the Charite (N.S.), Humboldt-University, Berlin Institute of Pathology (K.H.), Medical School, Hannover, Germany.
authors.forename: Henning
authors.initials: H
authors.lastname: Feist
authors.forename: Almuth
authors.initials: A
authors.lastname: Caliebe
authors.forename: Jennifer
authors.initials: J
authors.lastname: Oates
authors.forename: Nanette
authors.initials: N
authors.lastname: Sarioglu
authors.forename: Kais
authors.initials: K
authors.lastname: Hussein
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000098:blood supply / Q000235:genetics / Q000473:pathology*; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D057885:Triploidy; D014594:Uterine Neoplasms / Q000235:genetics / Q000473:pathology*