title: [Concurrent inpatient smoking cessation and alcohol abstinence programs for alcoholics and their outcomes].
abstract: Alcoholics have a high prevalence of nicotine dependence, and smoking is a major contributor to their high mortality. Three weeks after admission to an addiction center in Japan, 193 alcoholic men who were participating in an 11-week concurrent inpatient smoking cessation and alcohol abstinence programs filled out an anonymous self-report questionnaire regarding smoking and drinking, and 6 months after the completion of the programs, 83 patients were asked to respond to a mailed questionnaire about their smoking and drinking status. Of the 193 subjects, 73.3% were current smokers, but many were highly motivated in regard to both smoking cessation and alcohol abstinence. The subjects' scores on a 0 to 10 point scale for rating motivation and confidence in regard to smoking cessation and smoking urge were significantly correlated with each other and with their scores for motivation and confidence in regard to alcohol abstinence and drinking urge. Three weeks after admission, varenicline treatment was well-tolerated, and the varenicline group had a high rate of smoking cessation than the smoker group not treated with varenicline (67.7% vs. 44.6%, p = 0.012). Forty-six (55.4%) of the 83 subjects who were mailed the questionnaire responded, and the drinking category was 'totally abstinent' in 35 subjects (42.2%), and 'mostly abstinent' in another 4 subjects (4.8%). Seventeen (20.5%) of the 83 subjects were non-smokers before treatment, but after treatment, 23 (50.0%) of the 46 responders and 20 (51.3%) of the 'totally or mostly abstinent' 39 responders were total or almost non-smokers. The response rate of 'totally or mostly abstinent' was higher among the 17 non-smokers before treatment than among the 66 smokers before treatment (70.6% vs. 40.9%, p = 0.033), and the age-adjusted odds ratio (95% confidence interval) for the response of 'totally or mostly abstinent' was 3.30 (1.03-10.56) for the non-smokers before treatment (vs. the smokers before treatment). In conclusion, smoking status had a great impact on the drinking status of treatment-seeking alcoholic men, and smoking cessation should be recommended to smoking alcoholics.
authors.forename: Akira
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mizukami
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakuma
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Junichi
authors.initials: J
authors.lastname: Yoneda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Maesato
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kimura
authors.forename: Sachio
authors.initials: S
authors.lastname: Matsushita
authors.forename: Susumu
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000328:Adult; D000368:Aged; D064829:Alcohol Abstinence; D000437:Alcoholism / Q000523:psychology* / Q000628:therapy*; D001552:Benzazepines / Q000008:administration & dosage; D015928:Cognitive Behavioral Therapy; D005260:Female; D006801:Humans; D007297:Inpatients / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000008:administration & dosage; D011810:Quinoxalines / Q000008:administration & dosage; D012907:Smoking / Q000523:psychology*; D016540:Smoking Cessation / Q000379:methods*; D000074606:Smoking Prevention; D016896:Treatment Outcome; D000068580:Varenicline; D055815:Young Adult
chemical_list: D001552:Benzazepines; D018722:Nicotinic Agonists; D011810:Quinoxalines; D000068580:Varenicline