title: Self-assembled anchor layers/polysaccharide coatings on titanium surfaces: a study of functionalization and stability.
abstract: Composite materials based on a titanium support and a thin, alginate hydrogel could be used in bone tissue engineering as a scaffold material that provides biologically active molecules. The main objective of this contribution is to characterize the activation and the functionalization of titanium surfaces by the covalent immobilization of anchoring layers of self-assembled bisphosphonate neridronate monolayers and polymer films of 3-aminopropyltriethoxysilane and biomimetic poly(dopamine). These were further used to bind a bio-functional alginate coating. The success of the titanium surface activation, anchoring layer formation and alginate immobilization, as well as the stability upon immersion under physiological-like conditions, are demonstrated by different surface sensitive techniques such as spectroscopic ellipsometry, infrared reflection-absorption spectroscopy and X-ray photoelectron spectroscopy. The changes in morphology and the established continuity of the layers are examined by scanning electron microscopy, surface profilometry and atomic force microscopy. The changes in hydrophilicity after each modification step are further examined by contact angle goniometry.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Ognen
authors.initials: O
authors.lastname: Pop-Georgievski
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Dana
authors.initials: D
authors.lastname: Kubies
authors.affiliation: Institute of Physics, Academy of Sciences of the Czech Republic, Cukrovarnicka 10, 16253 Prague 6, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Zemek
authors.affiliation: Institute of Physics, Academy of Sciences of the Czech Republic, Cukrovarnicka 10, 16253 Prague 6, Czech Republic.|Czech Technical University in Prague, Faculty of Nuclear Sciences and Physical Engineering, Trojanova 13, 12000 Prague 2, Czech Republic.
authors.forename: Neda
authors.initials: N
authors.lastname: Neykova
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Roman
authors.initials: R
authors.lastname: Demianchuk
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Eliška Mázl
authors.initials: EM
authors.lastname: Chánová
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Šlouf
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: Milan
authors.initials: M
authors.lastname: Houska
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky sq. 2, 16206 Prague 6, Czech Republic.
authors.forename: František
authors.initials: F
authors.lastname: Rypáček
keywords: XPS; alginate; biomimetic surfaces; bisphosphonates; neridronate; poly(dopamine); spectroscopic ellipsometry; surface characterization; surface modification; titanium
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