title: Global and regional brain volumes normalization in weight-recovered adolescents with anorexia nervosa: preliminary findings of a longitudinal voxel-based morphometry study.
abstract: The recent literature on anorexia nervosa (AN) suggests that functional and structural abnormalities of cortico-limbic areas might play a role in the evolution of the disease. We explored global and regional brain volumes in a cross-sectional and follow-up study on adolescents affected by AN. Eleven adolescents with AN underwent a voxel-based morphometry study at time of diagnosis and immediately after weight recovery. Data were compared to volumes carried out in eight healthy, age and sex matched controls. Subjects with AN showed increased cerebrospinal fluid volumes and decreased white and gray matter volumes, when compared to controls. Moreover, significant regional gray matter decrease in insular cortex and cerebellum was found at time of diagnosis. No regional white matter decrease was found between samples and controls. Correlations between psychological evaluation and insular volumes were explored. After weight recovery gray matter volumes normalized while reduced global white matter volumes persisted.
authors.affiliation: Child and Adolescent Mental Health Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Bomba
authors.affiliation: Child and Adolescent Mental Health Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Riva
authors.affiliation: Medical Physics Department, San Gerardo Hospital, Monza, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Morzenti
authors.affiliation: Department of Radiology, Humanitas Research Hospital, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Grimaldi
authors.affiliation: Child and Adolescent Mental Health Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Neri
authors.affiliation: Child and Adolescent Mental Health Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
authors.forename: Renata
authors.initials: R
authors.lastname: Nacinovich
keywords: adolescent; anorexia nervosa; gray matter; insula; voxel-based morphometry study
references.citation: Science. 1978 Jun 2;200(4345):1076-8
references.pmid: 653357
references.citation: Neuropsychologia. 2010 Aug;48(10):2878-85
references.pmid: 20553738
references.citation: Neuroradiology. 1985;27(4):304-12
references.pmid: 3876520
references.citation: Cerebellum. 2007;6(3):254-67
references.pmid: 17786822
references.citation: Neuroimage. 2012 Jan 16;59(2):1106-13
references.pmid: 21967727
references.citation: Psychother Psychosom. 1987;48(1-4):176-80
references.pmid: 3505712
references.citation: Acta Psychiatr Scand Suppl. 1980;286:41-6
references.pmid: 6935923
references.citation: Psychiatry Res. 2005 Dec 30;140(3):251-8
references.pmid: 16288853
references.citation: Int J Eat Disord. 2013 Dec;46(8):841-8
references.pmid: 23904101
references.citation: Neuroimage. 2008 Jul 1;41(3):903-13
references.pmid: 18424084
references.citation: Expert Opin Med Diagn. 2012 May 1;6(3):235-244
references.pmid: 22936952
references.citation: Int J Eat Disord. 2003 Jan;33(1):33-44
references.pmid: 12474197
references.citation: Ital J Pediatr. 2013 Feb 19;39:14
references.pmid: 23418915
references.citation: J Pediatr. 1996 Feb;128(2):296-301
references.pmid: 8636835
references.citation: Am J Psychiatry. 2007 Dec;164(12):1842-9
references.pmid: 18056239
references.citation: J Endocrinol Invest. 2006 Jul-Aug;29(7):581-93
references.pmid: 16957405
references.citation: Psychiatry Res. 1997 Dec 30;76(2-3):139-41
references.pmid: 9522406
references.citation: J Neurodev Disord. 2012 Jul 06;4(1):19
references.pmid: 22958744
references.citation: BMC Psychiatry. 2011 Nov 17;11:179
references.pmid: 22093442
references.citation: J Pediatr. 1996 Dec;129(6):794-803
references.pmid: 8969719
references.citation: Nat Rev Neurosci. 2009 Aug;10(8):573-84
references.pmid: 19603056
references.citation: J Psychiatr Res. 2009 Jan;43(3):331-40
references.pmid: 18486147
references.citation: Arch Pediatr Adolesc Med. 1997 Aug;151(8):793-7
references.pmid: 9265880
references.citation: Eur Eat Disord Rev. 2012 Mar;20(2):94-105
references.pmid: 22052722
references.citation: Am J Psychiatry. 1986 Jan;143(1):96-8
references.pmid: 3942296
references.citation: J Comput Assist Tomogr. 1977 Oct;1(4):415-8
references.pmid: 615219
references.citation: Psychol Med. 1996 Jan;26(1):15-28
references.pmid: 8643754
references.citation: Arch Gen Psychiatry. 1997 Jun;54(6):537-42
references.pmid: 9193194
references.citation: Cleve Clin J Med. 2011 Jan;78(1):50-8
references.pmid: 21199907
references.citation: Neuroimage. 2002 Jan;15(1):273-89
references.pmid: 11771995
references.citation: J Clin Endocrinol Metab. 2011 Feb;96(2):333-43
references.pmid: 21159848
references.citation: Int J Eat Disord. 2004 Sep;36(2):238-41
references.pmid: 15282696
references.citation: Psychiatry Res. 2011 Jan 30;191(1):24-30
references.pmid: 21081268
references.citation: J Radiol. 2003 Apr;84(4 Pt 1):369-79
references.pmid: 12759650
references.citation: Cardiol Rev. 2006 Sep-Oct;14(5):227-31
references.pmid: 16924163
references.citation: Psychiatry Res. 2011 Jun 30;192(3):154-9
references.pmid: 21546219
references.citation: Neuroimage. 2000 Jun;11(6 Pt 1):805-21
references.pmid: 10860804