title: [Oxidative stress in perioperative period of cesarean section].
abstract: OBJECTIVE
  To assess a pro- and antioxidant status in pregnant women at the system level in the perioperative period of cesarean section under regional and general anaesthesia.
  
  
  METHODS
  62 pregnant women aged 21 to 37 years (30,9 ± 6,2 y,ears) undergone delivery by cesarean section under general (n = 33) and regional (29) anaesthesia (1-2 class ASA (American Society ofAnesthesiologists). Blood samples were collected immediately after placing patients on an operating table (T1), immediately after suturing the surgical wound (T2), and 12 (T3) and 24 (T4) hours after taking the first sample. We studied following parameters: superoxide dismutase (SOD), glutathione peroxidase (GP). reduced glutathione (RG), total antioxidant activity, active products that react with thiobarbituric acid (TBA-ap).
  
  
  RESULTS
  In general anaesthesia cesarean critical period activation ofprooxidant and antlioxidant activity is the period T2. Activation prooxidant activity (TBA-ap) was stored at 12 and 24 hours after surgery. Increased antioxidant activity (SOD, GP) was observed in the period T2. which wass replaced by its inhibition to 24 hours. Reduced glutathione content (RG) was reduced during T2 remains at low values up to 24 hours. Regional anaesthesia did not change observed prooxidant (poorly marked increase antioxidant activity (SOD, GP), which persists up to 24 hours). Reduced glutathione content (RG) was reduced in the period T3. but recovered after 24 hours.
  
  
  CONCLUSIONS
  The use of regional imnaesthesia and spontaneous breathing with atmospheric air during an elective caesarean section helps to avoid induction and manifestations of oxidative stress in pregnant women in the perioperative period and to fully implement the program early activation parturients after cesarean section.
authors.forename: A V
authors.initials: AV
authors.lastname: Burlev
authors.forename: V A
authors.initials: VA
authors.lastname: Burlev
authors.forename: N A
authors.initials: NA
authors.lastname: Il'iasova
authors.forename: E M
authors.initials: EM
authors.lastname: Shifman
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural / Q000379:methods*; D000768:Anesthesia, General / Q000379:methods*; D000775:Anesthesia, Spinal / Q000379:methods*; D000975:Antioxidants / Q000378:metabolism*; D002585:Cesarean Section / Q000379:methods*; D005260:Female; D005865:Gestational Age; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D018384:Oxidative Stress; D059035:Perioperative Period; D011247:Pregnancy; D012121:Respiration, Artificial; D013482:Superoxide Dismutase / Q000097:blood; D013858:Thiobarbiturates / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D013858:Thiobarbiturates; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; C029684:thiobarbituric acid