title: Electronic imaging to enhance lesion detection at colonoscopy.
abstract: Adenoma removal prevents colorectal cancer (CRC) development. Lower adenoma detection rates correlate with increased postcolonoscopy CRC. Chromoendoscopy it is not practical for routine use. It was hoped that electronic imaging techniques would offer effective alternatives to improve detection; however, meta-analyses in average-risk patients indicate no benefit. Narrow band imaging may be of benefit for high-risk surveillance. Combining electronic imaging techniques with molecular imaging probes may highlight dysplasia at a molecular level. In future colonoscopy is likely to rely on sensitive and specific, labeled molecular probes detected by electronic endoscopic imaging to enhance detection and reduce miss rates for premalignant lesions.
authors.affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
authors.forename: Shara Nguyen
authors.initials: SN
authors.lastname: Ket
authors.affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bird-Lieberman
authors.affiliation: Translational Gastroenterology Unit, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK. Electronic address: jameseast6@yahoo.com.
authors.forename: James E
authors.initials: JE
authors.lastname: East
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003113:Colonoscopy / Q000379:methods*; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D061848:Optical Imaging / Q000379:methods
keywords: Adenoma; Colonic polyps; Colonoscopy; Colorectal cancer; Inflammatory bowel disease; Lectins; Lynch syndrome; Molecular imaging; Surveillance