title: Dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.
abstract: BACKGROUND
  Dexmedetomidine as an adjuvant to local anesthetics in peripheral nerve blocks has been used in only a few studies.
  
  
  OBJECTIVE
  We aimed at assessing the effect of dexmedetomidine as an adjuvant to ropivacaine in supraclavicular brachial plexus block.
  
  
  METHODS
  Random, controlled, and triple blind.
  
  
  METHODS
  Sixty American Society of Anesthesiologist grade I and II patients of either sex scheduled for elective upper limb surgery under supraclavicular brachial plexus block were divided into three equal groups in a prospective randomized double-blind controlled manner. For block patients in Group C received 0.5% ropivacaine (30cc), 0.5% ropivacaine with 50 μg dexmedetomidine (30cc) in Group D and 0.5% ropivacaine (30cc) in Group D-IV along with intravenous infusion of 50 μg dexmedetomidine in normal saline.
  
  
  METHODS
  IBM-SPSS software version 17, Chi-square test, Mann-Whitney U-test.
  
  
  RESULTS
  Demographic profile and surgical characteristics were similar in all the three groups. Sensory block and motor block onset was earlier in group D than in group D-IV and group C. The sensory block and motor block duration was also prolonged in group D when compared with group D-IV and group C. The duration of analgesia was significantly longer in group D and D-IV when compared to group C.
  
  
  CONCLUSIONS
  Dexmedetomidine as an adjuvant to 0.5%ropivacaine in ultrasound guided brachial plexus block shortens the sensory as well as motor block onset time, prolongs sensory and motor block duration and also increases the duration of analgesia. The action of dexmedetomidine most probably is local rather than centrally mediated.
authors.affiliation: Department of Anesthesia. Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors.forename: Suneet
authors.initials: S
authors.lastname: Kathuria
authors.affiliation: Department of Anesthesia. Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors.forename: Shikha
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Anesthesia. Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
authors.forename: Ira
authors.initials: I
authors.lastname: Dhawan
keywords: Dexmedetomidine; ropivacaine; supraclavicular brachial plexus block
references.citation: Anesthesiology. 2008 Sep;109(3):502-11
references.pmid: 18719449
references.citation: Br J Anaesth. 2013 Mar;110(3):438-42
references.pmid: 23161360
references.citation: Anesth Analg. 1992 Oct;75(4):602-6
references.pmid: 1530173
references.citation: J Anaesthesiol Clin Pharmacol. 2014 Jan;30(1):36-40
references.pmid: 24574591
references.citation: Eur J Pharmacol. 1988 Feb 9;146(2-3):223-8
references.pmid: 3163552
references.citation: Anesth Analg. 2000 May;90(5):1122-8
references.pmid: 10781465
references.citation: Anesth Analg. 1998 Dec;87(6):1316-9
references.pmid: 9842819
references.citation: Anesthesiology. 2009 Nov;111(5):1111-9
references.pmid: 19858875
references.citation: Reg Anesth Pain Med. 2010 Sep-Oct;35(5):427-31
references.pmid: 20814283
references.citation: Biochim Biophys Acta. 1990 May 7;1031(2):163-224
references.pmid: 2160274
references.citation: Acta Anaesthesiol Scand. 2006 Feb;50(2):222-7
references.pmid: 16430546
references.citation: Int J Clin Exp Med. 2014 Mar 15;7(3):680-5
references.pmid: 24753763
references.citation: Anesth Analg. 2010 Dec;111(6):1548-51
references.pmid: 20889939
references.citation: Eur J Anaesthesiol. 2009 Oct;26(10):851-5
references.pmid: 19550340
references.citation: Indian J Anaesth. 2012 May;56(3):243-9
references.pmid: 22923822