title: [GABA-ergic mechanism of cerebrovascular and antiischemic effects of docosahexaenoic acid].
abstract: In experiments on rats, measurements of the local blood flow in the cortex of cerebrum with the aid of a laser Doppler flow meter showed that docosahexaenoic acid (DHA) enhanced the local cerebral circulation in animals with global transient cerebral ischemia, while not influencing that in intact animals. This vasodilatory effect of DHA in ischemized rats is blocked by bicuculline (specific GABA(A) receptor blocker), which is indicative of a GABA-ergic mechanisms of the vascular tone regulation. The results of radioligand binding assay in vitro showed the possibility of direct DHA interaction with cerebrovascular GABA(A) receptors.
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: G I
authors.initials: GI
authors.lastname: Kovalev
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Firstova
authors.forename: V V
authors.initials: VV
authors.lastname: Bezuglov
authors.forename: N M
authors.initials: NM
authors.lastname: Gretskaia
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D007275:Injections, Intravenous; D017078:Laser-Doppler Flowmetry; D008297:Male; D011724:Pyridazines / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism*; D014316:Tritium; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D058787:GABA-A Receptor Antagonists; D011724:Pyridazines; D011963:Receptors, GABA-A; D014665:Vasodilator Agents; D014316:Tritium; D004281:Docosahexaenoic Acids; C049853:gabazine; D001640:Bicuculline