title: Use of aromatase inhibitors in practice of gynecology.
abstract: OBJECTIVE
  The conversion of androgens into estrogens by aromatase is called aromatization and is inhibited by aromatase inhibitors (AIs). The aim of this article is to evaluate the use of aromatase inhibitors in gynecological diseases such as endometriosis, leiomyoma, estrogen- dependent gynecologic neoplasia and infertility.
  
  
  METHODS
  This is a review of literature combined with experience and use of aromatase inhibitors ın practıce of gynecology.
  
  
  CONCLUSIONS
  AIs are promising agents in treatment of estrogen dependent disease. However lack of experience, side effects and cost are limiting factors for using these agents in infertility treatment. However there is need for larger, well designed randomized trials to generate robust data in order to establish the true potential of aromatase inhibitors.
authors.forename: Betul
authors.initials: B
authors.lastname: Usluogullari
authors.forename: Candan
authors.initials: C
authors.lastname: Duvan
authors.forename: Celil
authors.initials: C
authors.lastname: Usluogullari
mesh_terms: D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006176:Gynecology / Q000379:methods; D006801:Humans
chemical_list: D047072:Aromatase Inhibitors
references.citation: J Clin Endocrinol Metab. 1994 Dec;79(6):1831-4
references.pmid: 7989490
references.citation: Fertil Steril. 2004 Feb;81(2):290-6
references.pmid: 14967362
references.citation: Fertil Steril. 1993 Jul;60(1):95-8
references.pmid: 8513965
references.citation: Endocr Rev. 2009 Jun;30(4):343-75
references.pmid: 19389994
references.citation: J Steroid Biochem Mol Biol. 1994 Jun;49(4-6):281-7
references.pmid: 8043490
references.citation: Int J Gynaecol Obstet. 2008 Jan;100(1):10-2
references.pmid: 17889878
references.citation: J Am Acad Dermatol. 2001 Sep;45(3 Suppl):S116-24
references.pmid: 11511861
references.citation: Lancet Oncol. 2006 Aug;7(8):633-43
references.pmid: 16887480
references.citation: J Clin Endocrinol Metab. 2006 Mar;91(3):760-71
references.pmid: 16384846
references.citation: Curr Opin Oncol. 2007 Jul;19(4):347-52
references.pmid: 17545798
references.citation: Hum Reprod Update. 2012 May-Jun;18(3):301-12
references.pmid: 22431566
references.citation: Obstet Gynecol. 2007 Sep;110(3):643-9
references.pmid: 17766612
references.citation: Obstet Gynecol. 2007 Jun;109(6):1421-3
references.pmid: 17540816
references.citation: Reprod Biomed Online. 2006 Aug;13(2):208-12
references.pmid: 16895634
references.citation: J Clin Oncol. 2002 Aug 1;20(15):3317-27
references.pmid: 12149306
references.citation: Fertil Steril. 2006 Jun;85(6):1761-5
references.pmid: 16650422
references.citation: J Assist Reprod Genet. 1998 Apr;15(4):193-7
references.pmid: 9565848
references.citation: Aust N Z J Obstet Gynaecol. 2001 Feb;41(1):65-8
references.pmid: 11284649
references.citation: Int J Gynecol Cancer. 2008 Jul-Aug;18(4):600-14
references.pmid: 17894799
references.citation: J Clin Oncol. 2005 Jul 1;23(19):4347-53
references.pmid: 15824416
references.citation: Trends Endocrinol Metab. 1999 Oct;10(8):301-311
references.pmid: 10481160
references.citation: J Clin Endocrinol Metab. 1994 Mar;78(3):736-43
references.pmid: 8126151
references.citation: Fertil Steril. 2005 Aug;84(2):300-4
references.pmid: 16084868
references.citation: Ann Oncol. 2008 Aug;19(8):1407-16
references.pmid: 18448451
references.citation: Best Pract Res Clin Obstet Gynaecol. 2004 Oct;18(5):773-88
references.pmid: 15380146
references.citation: Int J Gynecol Cancer. 2004 Jul-Aug;14(4):650-8
references.pmid: 15304161
references.citation: Br Med J (Clin Res Ed). 1985 Dec 14;291(6510):1693-7
references.pmid: 3935248
references.citation: J Reprod Med. 1997 Apr;42(4):247-50
references.pmid: 9131500
references.citation: Hum Fertil (Camb). 2008 Mar;11(1):17-22
references.pmid: 18320435
references.citation: Fertil Steril. 2011 Oct;96(4):939-42
references.pmid: 21868006
references.citation: Hum Reprod. 2004 Sep;19(9):2031-5
references.pmid: 15217999
references.citation: Eur J Obstet Gynecol Reprod Biol. 2009 May;144(1):48-53
references.pmid: 19261371
references.citation: Hum Reprod. 1999 Nov;14(11):2700-3
references.pmid: 10548604
references.citation: DNA. 1988 Jan-Feb;7(1):27-38
references.pmid: 3390233
references.citation: Fertil Steril. 2010 Jan;93(1):192-8
references.pmid: 19135657
references.citation: J Steroid Biochem Mol Biol. 2005 May;95(1-5):57-62
references.pmid: 16024248
references.citation: Drug Saf. 1999 Oct;21(4):297-309
references.pmid: 10514021
references.citation: BJOG. 2008 Jun;115(7):818-22
references.pmid: 18485158
references.citation: Reprod Biol Endocrinol. 2011;9:88
references.pmid: 21693037
references.citation: J Biol Chem. 1974 Sep 10;249(17):5364-72
references.pmid: 4153532
references.citation: Fertil Steril. 2009 Jun;91(6):2501-7
references.pmid: 18501899
references.citation: Semin Reprod Med. 2004 Feb;22(1):61-78
references.pmid: 15083382
references.citation: Fertil Steril. 2001 Feb;75(2):305-9
references.pmid: 11172831
references.citation: Fertil Steril. 2005 Jan;83(1):229-31
references.pmid: 15652918
references.citation: Reprod Biol Endocrinol. 2011;9:84
references.pmid: 21693030
references.citation: N Engl J Med. 2002 Jan 31;346(5):340-52
references.pmid: 11821512
references.citation: Hum Reprod. 2004 Jan;19(1):160-7
references.pmid: 14688176
references.citation: Eur J Cancer. 2000 Sep;36 Suppl 4:S59-61
references.pmid: 11056321
references.citation: Fertil Steril. 2006 Feb;85(2):277-84
references.pmid: 16595197
references.citation: Int J Gynaecol Obstet. 2011 Jun;113(3):218-21
references.pmid: 21457973
references.citation: Fertil Steril. 2009 Sep;92(3):858-9
references.pmid: 17588568
references.citation: Fertil Steril. 2009 Jan;91(1):240-3
references.pmid: 18249392
references.citation: J Clin Endocrinol Metab. 2002 Jun;87(6):2540-8
references.pmid: 12050211
references.citation: Fertil Steril. 2011 Jan;95(1):291.e15-8
references.pmid: 20579642
references.citation: J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):19-25
references.pmid: 11850203
references.citation: Fertil Steril. 2011 Nov;96(5):1206-8
references.pmid: 21867999
references.citation: Reprod Biomed Online. 2007 May;14(5):559-62
references.pmid: 17509194
references.citation: Curr Opin Investig Drugs. 2003 Oct;4(10):1209-12
references.pmid: 14649213
references.citation: Obstet Gynecol. 1994 Feb;83(2):189-96
references.pmid: 8290180
references.citation: Hum Reprod Update. 2008 Nov-Dec;14(6):571-82
references.pmid: 18812422
references.citation: Fertil Steril. 2005 Jul;84(1):82-7
references.pmid: 16009161
references.citation: J Soc Gynecol Investig. 2004 Sep;11(6):406-15
references.pmid: 15350255
references.citation: Am J Obstet Gynecol. 1986 Dec;155(6):1154-9
references.pmid: 2947467
references.citation: Am J Obstet Gynecol. 2005 Feb;192(2):381-6
references.pmid: 15695975
references.citation: Endocr Rev. 1992 Nov;13(4):641-69
references.pmid: 1281087
references.citation: J Steroid Biochem Mol Biol. 2011 May;125(1-2):13-22
references.pmid: 21335088
references.citation: Cochrane Database Syst Rev. 2014;2:CD010287
references.pmid: 24563180