title: Sesquiterpene coumarins from seeds of Ferula sinkiangensis.
abstract: A new sesquiterpene coumarin with a novel sesquiterpene carbon framework, Sinkiangenorin D, and ten known sesquiterpene coumarins were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds, including the relative stereochemistry, were elucidated on the basis of spectroscopic data. All of the isolated compounds were tested against the AGS, HeLa, and K562 human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 12.7 and 226.6 μM.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Li
authors.affiliation: Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors.forename: Lijing
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors.forename: Liangang
authors.initials: L
authors.lastname: Shen
authors.affiliation: Xinjiang Institute of Chinese Materia Medica and Ethical Materia Medica, Urumqi 830002, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China.
authors.forename: Junchi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address: jianyongsi@126.com.
authors.forename: Jianyong
authors.initials: J
authors.lastname: Si
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D003374:Coumarins / Q000494:pharmacology*; D005309:Ferula / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*; D012717:Sesquiterpenes / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D012717:Sesquiterpenes; C000601290:sinkiangenorin D; C030123:coumarin
keywords: Colladonin (PubChem CID: 375430); Cytotoxic activities; Episamarcandin; Farnesiferl C (PubChem CID: 15559239); Feklone; Fekrynol; Ferula sinkiangensis; Feselol (PubChem CID: 17977); Lehmannolol; Lehmannolone; Sesquiterpene; Sesquiterpene coumarin; Sinkianone; Umbelliprenin (PubChem CID: 1781413)