title: Fabrication of aluminum terephthalate metal-organic framework incorporated polymer monolith for the microextraction of non-steroidal anti-inflammatory drugs in water and urine samples.
abstract: Polymer monolith microextraction (PMME) based on capillary monolithic column is an effective and useful technique to preconcentrate trace analytes from environmental and biological samples. Here, we report the fabrication of a novel aluminum terephthalate metal-organic framework (MIL-53(Al)) incorporated capillary monolithic column via in situ polymerization for the PMME of non-steroidal anti-inflammatory drugs (NSAIDs) (ketoprofen, fenbufen and ibuprofen) in water and urine samples. The fabricated MIL-53(Al) incorporated monolith was characterized by X-ray powder diffractometry, scanning electron microscopy, Fourier transform infrared spectrometry, and nitrogen adsorption experiment. The MIL-53(Al) incorporated monolith gave larger surface area than the neat polymer monolith. A 2-cm long MIL-53(Al) incorporated capillary monolith was applied for PMME coupled with high-performance liquid chromatography for the determination of the NSAIDs. Potential factors affecting the PMME were studied in detail. Under the optimized conditions, the developed method gave the enhancement factors of 46-51, the linear range of 0.40-200μgL(-1), the detection limits (S/N=3) of 0.12-0.24μgL(-1), and the quantification limits (S/N=10) of 0.40-0.85μgL(-1). The recoveries for spiked NSAIDs (20μgL(-1)) in water and urine samples were in the range of 77.3-104%. Besides, the MIL-53(Al) incorporated monolith was stable enough for 120 extraction cycles without significant loss of extraction efficiency. The developed method was successfully applied to the determination of NSAIDs in water and urine samples.
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Dan-Ya
authors.initials: DY
authors.lastname: Lyu
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address: cxyang@nankai.edu.cn.
authors.forename: Cheng-Xiong
authors.initials: CX
authors.lastname: Yang
authors.affiliation: College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology (Nankai University), Tianjin Key Laboratory of Molecular Recognition and Biosensing, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address: xpyan@nankai.edu.cn.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yan
mesh_terms: D000327:Adsorption; D000535:Aluminum; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000652:urine; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D007052:Ibuprofen / Q000302:isolation & purification* / Q000652:urine; D007660:Ketoprofen / Q000302:isolation & purification* / Q000652:urine; D057230:Limit of Detection; D008689:Methacrylates; D010654:Phenylbutyrates / Q000302:isolation & purification* / Q000652:urine; D010795:Phthalic Acids; D012492:Salts; D052616:Solid Phase Extraction / Q000295:instrumentation* / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008689:Methacrylates; D010654:Phenylbutyrates; D010795:Phthalic Acids; D012492:Salts; C516546:poly(butyl methacrylate-co-ethylene dimethacrylate); D014867:Water; C011363:terephthalic acid; D007660:Ketoprofen; C010725:fenbufen; D000535:Aluminum; D007052:Ibuprofen
keywords: High-performance liquid chromatography; Metal-organic frameworks; Monolith; Non-steroidal anti-inflammatory drugs; Polymer monolith microextraction