title: Palladium-catalyzed picolinamide-directed coupling of C(sp(2))-H and C(sp(2))-H: a straightforward approach to quinolinone and pyridone scaffolds.
abstract: An unprecedented palladium-catalyzed picolinamide-directed coupling of C(sp(2))-H and C(sp(2))-H has been developed with exclusive formation of the six-membered ring heterocyclics - quinolinone and pyridone. The method employs cyclic hypervalent iodine as oxidant and features good functional-group tolerance. Another advantage of this reaction is that sequential C-H/C-H and C-H/N-H coupling could be achieved.
authors.affiliation: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China. hliu@mail.shcnc.ac.cn.
authors.forename: Dengyou
authors.initials: D
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Yong
authors.initials: Y
authors.lastname: Nian
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hualiang
authors.initials: H
authors.lastname: Jiang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu