title: Down Expression of FBP1 Is a Negative Prognostic Factor for Non-Small-Cell Lung Cancer.
abstract: Downregulation of fructose-1,6-bisphosphatse-1 (FBP1) was observed in several cancers but its role in the lung cancer still remains unknown. We examined the cancer tissues from 140 patients with nonsmall cell lung cancer patients and found that the relative gene expression of FBP1 was significantly lower in lung cancer tissues as compared to incisal marginal tissues and normal tissues. The patients with higher level of FBP1 RNA expression have significantly longer disease free survival and overall survival as compared to the lower expression groups. There was a negative correlation with the level of FBP1 and recurrence of the lung cancer.
authors.affiliation: 1Cancer Research Institute, Zhejiang Cancer Hospital , Hangzhou, Zhejiang , China.
authors.forename: Huaying
authors.initials: H
authors.lastname: Sheng
authors.forename: Lisha
authors.initials: L
authors.lastname: Ying
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Chihong
authors.initials: C
authors.lastname: Zhu
authors.forename: Junzhou
authors.initials: J
authors.lastname: Wu
authors.forename: Jianguo
authors.initials: J
authors.lastname: Feng
authors.forename: Dan
authors.initials: D
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D004265:DNA Helicases / Q000096:biosynthesis* / Q000235:genetics; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D016601:RNA-Binding Proteins
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C492258:FUBP1 protein, human; D016601:RNA-Binding Proteins; D004265:DNA Helicases
keywords: Down expression; FBP1; Non–small-cell lung cancer; Prognosis