title: In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta.
abstract: BACKGROUND
  The aerial parts of Thymelaea hirsuta (TH) are used as a decoction in the treatment of different pathologies in folk medicine in Morocco.
  
  
  OBJECTIVE
  The aqueous extracts were evaluated for its anti-inflammatory activity and in inhibition of adjuvant induction arthritis in male Wistar rats.
  
  
  METHODS
  The anti-inflammatory activity was carried out using carrageenan-induced rat paw edema model, and the antiarthritic activity was carried out using complete Freund's adjuvant-induced arthritis model.
  
  
  RESULTS
  The plant extract (500 mg/kg body weight) exhibited significant activity in acute inflammation produced 60% of inhibition after 4 h as compared with that of the standard anti-inflammatory drug, the diclofenac (100 mg/kg) which showed 40% of inhibition. In arthritis model, the extract produced 85% inhibition after 18 days when compared with the diclofenac (10 mg/kg; 72%).
  
  
  CONCLUSIONS
  These results indicate that the aqueous extract of TH had an anti-inflammatory activity and inhibited the induction of adjuvant arthritis in male Wistar rats.
authors.affiliation: Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco.
authors.forename: Zora
authors.initials: Z
authors.lastname: Azza
authors.affiliation: Department of Biology, Faculty of Sciences Ain Chock, Laboratory of Physiology and Molecular Genetics, Immunology Unit, University Hassan II, B.P. 5366, Mâarif, Casablanca, Morocco.
authors.forename: Mounia
authors.initials: M
authors.lastname: Oudghiri
keywords: Antiarthritis; Antiinflammation; Medicinal plants; Thymelaea hirsuta; Wistar rats
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