title: The identification and characterization of specific ARF-Aux/IAA regulatory modules in plant growth and development.
abstract: The current model of auxin-inducible transcription describes numerous regulatory interactions between AUXIN RESPONSE FACTORs (ARFs) and Aux/IAAs. However, specific relationships between individual members of these families in planta remain largely uncharacterized. Using a systems biology approach, the entire suite of Aux/IAA genes directly regulated by the developmentally pivotal ARF MONOPTEROS (MP) was recently determined for multiple Arabidopsis tissue types. This study showed that MP directly targets distinct subclades of Aux/IAAs, revealing potential regulatory modules of redundantly acting Aux/IAAs involved in MP-dependent processes. Further, functional analyses indicated that the protein products of these targeted Aux/IAAs negatively feedback on MP. Thus, comprehensive identification of Aux/IAAs targeted by individual ARFs will generate biologically meaningful networks of ARF-Aux/IAA regulatory modules controlling distinct plant pathways.
authors.affiliation: a Department of Biology ; American University ; Washington DC USA.
authors.forename: Naden T
authors.initials: NT
authors.lastname: Krogan
authors.forename: Thomas
authors.initials: T
authors.lastname: Berleth
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*; D008954:Models, Biological; D063245:Plant Development / Q000235:genetics
chemical_list: D029681:Arabidopsis Proteins; D007210:Indoleacetic Acids
keywords: ARF; AUXIN RESPONSE FACTOR (ARF); Arabidopsis development; Aux/IAA genes; Auxin Response Factor; GR; MONOPTEROS.; functional genomics; glucocorticoid receptor; MP; transcriptional regulatory network
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