title: Effects of antenatal magnesium exposure on intestinal blood flow and outcome in preterm neonates.
abstract: OBJECTIVE
  This study aims to investigate the effects of antenatal magnesium sulfate on intestinal blood flow in preterm neonates.
  
  
  METHODS
  In this prospective case-match study, 25 preterm neonates exposed to magnesium sulfate antenatally were included (study group). Overall, 25 gestational age-matched neonates who had no exposure to magnesium constituted the control group. Serial daily Doppler flow measurements of superior mesenteric artery (SMA) were performed. The time to reach full feeds, first meconium passage were assessed. Presence of feeding intolerance or necrotizing enterocolitis was recorded.
  
  
  RESULTS
  Blood flow velocities of SMA were not different between the groups during the first five postnatal days. However, SMA blood flow showed an increasing trend in the control group unlike the study group (control group, p < 0.001; study group, p = 0.29). There was no significant difference between the two groups regarding the time to reach full feeds or first meconium passage and presence of feeding intolerance. No case of necrotizing enterocolitis was seen.
  
  
  CONCLUSIONS
  Antenatal magnesium does not significantly affect intestinal blood flow, but it seems to attenuate the increasing trend of the intestinal blood flow in the early postnatal days. However, this study failed to show any impact of this finding on clinical outcomes.
authors.affiliation: Neonatal Intensive Care Unit, Department of Pediatrics, Koc University School of Medicine, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Gursoy
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Ebru Yalin
authors.initials: EY
authors.lastname: Imamoglu
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Fahri
authors.initials: F
authors.lastname: Ovali
authors.affiliation: Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Guner
authors.initials: G
authors.lastname: Karatekin
mesh_terms: D001783:Blood Flow Velocity; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007422:Intestines / Q000098:blood supply*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D018608:Ultrasonography, Doppler
chemical_list: D008278:Magnesium Sulfate