title: A prospective randomized blinded clinical trial: large-volume nasal irrigation with fluticasone propionate in the early postoperative period following septoplasty.
abstract: BACKGROUND
  The aim of this study was to compare 2 methods of nasal irrigation after septoplasty. The combined use of low-pressure, high-volume nasal saline (LPHVNS) irrigation, together with fluticasone propionate (FP) (LPHVNS+FP), was compared with high-pressure, low-volume nasal saline (HPLVNS) irrigation during the early postoperative period following septoplasty.
  
  
  METHODS
  Seventy-three patients undergoing septoplasty for nasal obstruction were recruited for the study. The patients were randomly divided into 2 groups; nasal irrigation was applied for 4 weeks in both groups. Group 1 (n = 40) used HPLVNS irrigation. Group 2 (n = 33) used the LPHVNS+FP combination. The patients were evaluated using the visual analogue scale (VAS), Nasal Obstruction Symptom Evaluation (NOSE), nasal examination scores, acoustic rhinometry, rhinomanometry, and peak nasal inspiratory flowmetry (PNIF) measurements.
  
  
  RESULTS
  In group 2, the increase in VAS results was more prominent than in group 1. NOSE scores were significantly lower in group 2 than in group 1. The nasal examination revealed that group 2 had less edema and less crusting than group 1. The decrease in nasal airway resistance was significantly higher in group 2. The PNIF values increased to a significantly greater extent in group 2 than in group 1.
  
  
  CONCLUSIONS
  Nasal irrigation with the LPHVNS+FP combination during the early postoperative period following septoplasty is an effective method, resulting not only in increased patient satisfaction and nasal air flow but also in decreased edema and crust formation.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Tugrul
authors.affiliation: Department of Otorhinolaryngology, Bayrampaşa State Hospital, İstanbul, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Dogan
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Senturk
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Sabri Baki
authors.initials: SB
authors.lastname: Eren
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Meric
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Ozturan
mesh_terms: D000293:Adolescent; D000328:Adult; D004487:Edema / Q000517:prevention & control; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D055556:Nasal Lavage / Q000379:methods*; D009297:Nasal Mucosa / Q000187:drug effects*; D015508:Nasal Obstruction / Q000601:surgery*; D009300:Nasal Septum / Q000601:surgery*; D017060:Patient Satisfaction; D011182:Postoperative Care; D011446:Prospective Studies; D011897:Random Allocation; D012225:Rhinoplasty; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D000068298:Fluticasone
keywords: fluticasone propionate; irrigation; large volume; nasal; septoplasty