title: Lyme carditis--diagnosis, treatment and prognosis.
abstract: BACKGROUND
  There are 60,000 to 100,000 new cases of borreliosis in Germany each year. This infectious disease most commonly affects the skin, joints, and nervous system. Lyme carditis is a rare manifestation with potentially lethal complications.
  
  
  METHODS
  This review is based on selected publications on the clinical manifestations, diagnosis, and treatment of Lyme carditis, and on the authors' scientific and clinical experience.
  
  
  RESULTS
  Lyme carditis is seen in 4% to 10% of all patients with Lyme borreliosis. Whenever the clinical suspicion of Lyme carditis arises, an ECG is mandatory for the detection or exclusion of an atrioventricular conduction block. Patients with a PQ interval longer than 300 ms need continuous ECG monitoring. 90% of patients with Lyme carditis develop cardiac conduction abnormalities, and 60% develop signs of perimyocarditis. Borrelia serology (ELISA) may still be negative in the early phase of the condition, but is always positive in later phases. Cardiac MRI can be used to confirm the diagnosis and to monitor the patient's subsequent course. The treatment of choice is with antibiotics, preferably ceftriaxone. The cardiac conduction disturbances are usually reversible, and the implantation of a permanent pacemaker is only exceptionally necessary. There is no clear evidence at present for an association between borreliosis and the later development of a dilated cardiomyopathy. When Lyme carditis is treated according to the current guidelines, its prognosis is highly favorable.
  
  
  CONCLUSIONS
  Lyme carditis is among the rarer manifestations of Lyme borreliosis but must nevertheless be considered prominently in differential diagnosis because of the potentially severe cardiac arrhythmias that it can cause.
authors.affiliation: Internal Medicine Department I, Department of Cardiology, Memmingen Medical Center, affiliated teaching center of the LMU Munich, Internal Medicine Department I, Department of Cardiology, München-Pasing Medical Center, affiliated teaching center of the LMU Munich, Department of Molecular Pathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen.
authors.forename: Norbert
authors.initials: N
authors.lastname: Scheffold
authors.forename: Bernhard
authors.initials: B
authors.lastname: Herkommer
authors.forename: Reinhard
authors.initials: R
authors.lastname: Kandolf
authors.forename: Andreas E
authors.initials: AE
authors.lastname: May
mesh_terms: D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000628:therapy*; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D008193:Lyme Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D009205:Myocarditis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011379:Prognosis
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