title: Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin.
abstract: Kinins, such as Bradykinin (BK), are peptide hormones of the kallikrein-kinin system. Apart from being a vasodilator, BK also increases urinary sodium excretion to reduce systemic blood pressure. It is becoming appreciated that BK modulates function of the epithelial Na(+) channel in the distal part of the renal nephron to affect tubular sodium reabsorption. In this chapter, we outline the molecular details, as well as discuss the physiological relevance of this regulation for the whole organism sodium homeostasis and setting chronic blood pressure.
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Mykola
authors.initials: M
authors.lastname: Mamenko
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Oleg
authors.initials: O
authors.lastname: Zaika
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Nabila
authors.initials: N
authors.lastname: Boukelmoune
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Madden
authors.affiliation: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, Texas, USA. Electronic address: Oleh.M.Pochynyuk@uth.tmc.edu.
authors.forename: Oleh
authors.initials: O
authors.lastname: Pochynyuk
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001920:Bradykinin / Q000378:metabolism*; D053503:Epithelial Sodium Channels / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D009399:Nephrons / Q000378:metabolism*; D065608:Renal Reabsorption / Q000502:physiology*; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000502:physiology
chemical_list: D053503:Epithelial Sodium Channels; D012964:Sodium; D001920:Bradykinin
keywords: ACE inhibition; Blood pressure; Kidney; Natriuresis; Renal tubule; Salt sensitivity