title: Hydroxyapatite whisker reinforced 63s glass scaffolds for bone tissue engineering.
abstract: Bioactive glass (BG) is widely used for bone tissue engineering. However, poor mechanical properties are the major shortcomings. In the study, hydroxyapatite nanowhisker (HANw) was used as a reinforcement to improve the mechanical properties. 63s glass/HANw scaffolds were successfully fabricated by selective laser sintering (SLS). It was found that the optimal compressive strength and fracture toughness were achieved when 10 wt.% HANw was added. This led to 36% increase in compressive strength and 83% increase in fracture toughness, respectively, compared with pure 63s glass scaffolds. Different reinforcement mechanisms were analyzed based on the microstructure investigation. Whisker bridging and whisker pulling-out were efficient in absorbing crack propagating energy, resulting in the improvement of the mechanical properties. Moreover, bioactivity and biocompatibility of the scaffolds were evaluated in vitro. The results showed that composite scaffolds with 10 wt.% HANw exhibited good apatite-forming ability and cellular affinity.
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China ; Orthopedic Biomedical Materials Institute, Central South University, Changsha 410001, China.
authors.forename: Cijun
authors.initials: C
authors.lastname: Shuai
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.
authors.forename: Yiyuan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.
authors.forename: Chengde
authors.initials: C
authors.lastname: Gao
authors.affiliation: State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Feng
authors.affiliation: Orthopedic Biomedical Materials Institute, Central South University, Changsha 410001, China ; Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410001, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Xiao
authors.affiliation: Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha 410006, China ; School of Basic Medical Science, Central South University, Changsha 410078, China.
authors.forename: Shuping
authors.initials: S
authors.lastname: Peng
mesh_terms: D018786:Bone Substitutes / Q000138:chemical synthesis*; D002448:Cell Adhesion / Q000502:physiology; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005898:Glass / Q000737:chemistry*; D006244:Hardness; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; C570103:bioactive glass 63S; D017886:Durapatite
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