title: Mini review: linkage between α-Synuclein protein and cognition.
abstract: α-synuclein is a protein that plays important roles in cognitive function in the normal brain, although its exact role is not fully understood. However, current studies reveal that defects in α-synuclein function could contribute to various neurodegenerative disorders, such as Parkinson's disease (PD), a disease with symptomatic progression of deterioration in motor and cognitive function. Recent studies show that the level of α -synuclein in cerebrospinal fluid (CSF) is highly correlated with speed of cognitive decline, suggesting a potential role of α-synuclein in cognitive function. In this mini review, we will be focus on literatures of α-synuclein in cognitive function in the non-diseased brain, as well as the impact that defective α-synuclein has on cognition in disease brain. This will be accomplished by assessing the effects of soluble α-synuclein, α-synuclein oligomers, and extracellular α-synuclein transport, on neurodegeneration.
authors.affiliation: Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute, Sarasota, FL 34243 USA.
authors.forename: Huda
authors.initials: H
authors.lastname: Saleh
authors.affiliation: Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute, Sarasota, FL 34243 USA.
authors.forename: Ayeh
authors.initials: A
authors.lastname: Saleh
authors.affiliation: Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute, Sarasota, FL 34243 USA.
authors.forename: Hailan
authors.initials: H
authors.lastname: Yao
authors.affiliation: Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243 USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Cui
authors.affiliation: Center for Advanced Therapeutic Strategies for Brain Disorders Roskamp Institute, Sarasota, FL 34243 USA ; Neurodegenerative Disease Research Center, School of Life Sciences, University of Science and Technology of China, Anhui, 230027 China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243 USA ; Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100088 China.
authors.forename: Rena
authors.initials: R
authors.lastname: Li
keywords: Alzheimer’s disease; Cognition; Learning; Memory; Parkinson’s disease; α-Synuclein
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