title: [Participation of pineal gland in antistressor activity of adaptogenic drugs].
abstract: Chronic stress produces some morphological changes in rats, including thymus weight reduction, adrenal hypertrophy, and peptic ulcers in stomach. Repeated administration of phytoadaptogenic drugs (ginseng and bilobil) decreased these stress-induced disorders. The antistressor activity of drugs was attenuated upon by removal of the pineal gland. Histochemical and morphometric investigation of pineal tissues in stressed animals showed that that the pharmacological effect was accompanied by increasing functional activity of the pineal gland. It is suggested that pineal mobilization may participate in antistressor activity of phytoadaptogenic drugs.
authors.forename: É B
authors.initials: ÉB
authors.lastname: Arushanian
authors.forename: É V
authors.initials: ÉV
authors.lastname: Beĭer
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004597:Electroshock; D020441:Ginkgo biloba / Q000737:chemistry*; D006003:Glycogen / Q000378:metabolism; D007103:Immobilization; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013312:Stress, Physiological; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D014151:Anti-Anxiety Agents; D010936:Plant Extracts; D012313:RNA; D006003:Glycogen; D008550:Melatonin