title: Evaluation of weight loss and metabolic changes in diabetic patients treated with liraglutide, effect of RS 6923761 gene variant of glucagon-like peptide 1 receptor.
abstract: BACKGROUND
  A polymorphism of GLP-1 R (rs6923761) has potential implications in weight loss and metabolic control. We decide to investigate the role of this polymorphism on metabolic changes and weight loss secondary to treatment with liraglutide.
  
  
  METHODS
  A population of 90 patients with diabetes mellitus type 2 and overweight, unable to achieve glycemic control (HbA1c>7%) with metformin alone that require initiation of liraglutide treatment in progressive dose to 1.8mg/day subcutaneously, was analyzed.
  
  
  RESULTS
  Fifty one patients (56.7%) had the genotype GG and 39 (43.3%) patients; GA (30 patients, 33.3%) or AA (9 patients, 10%) (A allele carriers). In patients with both genotypes, body mass index (BMI), weight and fat decreased. The proportion of the mentioned reductions was higher in the variant allele carriers; BMI (-0.59±2.5kg/m(2) vs. -1.69±3.9kg/m(2); P<0.05), weight (-2.78±2.8kg vs. -4.52±4.6kg; P<0.05) and fat mass (-0.59±2.5kg vs. -1.69±3.9kg; P<0.05). Weight reduction after liraglutide treatment was greater in the A-allele carriers by 2.9kg (95% CI: 0.27-5.64). The decrease of basal glucose, HOMA-R and HbA1c was similar in both genotypes.
  
  
  CONCLUSIONS
  Our data showed better anthropometric parameters in overweight diabetic subjects with the variant allele (A) of rs6923761 GLP-1 R polymorphism. A allele carriers had a greater decrease in weight and fat mass after treatment with liraglutide. The present study is a preliminary observation, and its results need to be replicated with a higher number of patients in different populations.
authors.affiliation: Center of Investigation of endocrinology and Nutrition, Medicine School, Department of Endocrinology and Nutrition Hospital Clinico Universitario, University of Valladolid, Valladolid Spain. Electronic address: dadluis@yahoo.es.
authors.forename: Daniel Antonio
authors.initials: DA
authors.lastname: de Luis
authors.affiliation: Center of Investigation of endocrinology and Nutrition, Medicine School, Department of Endocrinology and Nutrition Hospital Clinico Universitario, University of Valladolid, Valladolid Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Diaz Soto
authors.affiliation: Center of Investigation of endocrinology and Nutrition, Medicine School, Department of Endocrinology and Nutrition Hospital Clinico Universitario, University of Valladolid, Valladolid Spain.
authors.forename: Olatz
authors.initials: O
authors.lastname: Izaola
authors.affiliation: Center of Investigation of endocrinology and Nutrition, Medicine School, Department of Endocrinology and Nutrition Hospital Clinico Universitario, University of Valladolid, Valladolid Spain.
authors.forename: Enrique
authors.initials: E
authors.lastname: Romero
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D005260:Female; D000067757:Glucagon-Like Peptide-1 Receptor / Q000235:genetics*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D000069450:Liraglutide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000008:administration & dosage; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D050177:Overweight / Q000150:complications / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D015431:Weight Loss / Q000187:drug effects* / Q000235:genetics
chemical_list: D001786:Blood Glucose; D000067757:Glucagon-Like Peptide-1 Receptor; D006442:Glycated Hemoglobin; D000069450:Liraglutide; D008687:Metformin; C517652:hemoglobin A1c protein, human
keywords: Glucagon-like peptide 1 receptor; Liraglutide; Metabolic parameters; Obesity; rs6923761