title: [Analysis of associations of polymorphic loci of a tumor suppressor gene TP53 with malignant neoplasms in glass fiber manufacturing workers].
abstract: The purpose of the study was to determine the role of TP53 tumor suppressor gene polymorphisms in the occurrence of skin malignant neoplasms in glass fiber manufacturing workers. We carried out a comparative study of polymorphous loci Arg72Pro and dup16bp in TP53 gene in workers with skin cancer and hyperkeratosis (n = 68), occupied in continuous glass fiber manufacture, and in healthy workers (n = 52). The associations of both Pro and dup16 minor alleles of TP53 gene, and Arg/Pro-W/dup16 genotype combination with higher risks for skin oncologic diseases of occupational genesis have been revealed.
authors.forename: G F
authors.initials: GF
authors.lastname: Mukhammadiyeva
authors.forename: A B
authors.initials: AB
authors.lastname: Bakirov
authors.forename: L K
authors.initials: LK
authors.lastname: Karimova
authors.forename: E T
authors.initials: ET
authors.lastname: Valeyeva
mesh_terms: D016022:Case-Control Studies; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005898:Glass; D006801:Humans; D007642:Keratosis / Q000139:chemically induced / Q000235:genetics; D066192:Manufacturing Industry; D009784:Occupational Diseases / Q000209:etiology / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012426:Russia; D012878:Skin Neoplasms / Q000139:chemically induced / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C009753:fiberglass