title: Distinct domains of impulsivity are impaired in juvenile myoclonic epilepsy but not in temporal lobe epilepsy.
abstract: OBJECTIVE
  The Barratt Impulsiveness Scale (BIS-11) is the most widely used questionnaire to study impulsivity in persons with psychiatric disorders, but it has rarely been applied to persons with epilepsy. The present study aimed to evaluate the usefulness of BIS-11 as a tool to explore impulsivity in two distinct epilepsy syndromes.
  
  
  METHODS
  The BIS-11 was applied to 20 patients with juvenile myoclonic epilepsy (JME) (32.5±8.95years old), 20 patients with temporal lobe epilepsy (TLE) (37.7±13.25years old), and 26 healthy controls (31.86±11.25years old). The scores in motor, attentional, and lack of planning impulsivity were compared between groups.
  
  
  RESULTS
  Patients with JME showed higher scores than patients with TLE and controls in all domains: motor (JME vs TLE: 28.60 vs 13.25 (mean score), p<0.001 and JME vs controls: 28.60 vs 14.12, p<0.001), attentional (JME vs TLE: 21.55 vs 13.45, p<0.001 and JME vs controls: 21.55 vs 14.88, p<0.001) and nonplanning (JME vs TLE: 28.05 vs 13.10, p<0.001 and JME vs controls: 28.05 vs 16.15, p<0.001).
  
  
  CONCLUSIONS
  Higher BIS-11 scores in all domains of impulsivity [i.e., motor, attentional, and lack of planning] corroborated previous findings described in patients with JME. On the other hand, BIS-11 could not demonstrate problem solving and inhibitory control deficits related to impulsive behavior, which were described in patients with TLE. Other behavioral measures may be more sensitive to some aspects of impulsivity in TLE. Our results reinforce the concept that distinct epileptic syndromes require different neuropsychological approaches, especially considering a complex construct such as impulsivity.
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil; Laboratory of Neuroimaging in Psychiatry, Clinics Hospital, University of Sao Paulo (USP), Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo (USP), Brazil. Electronic address: patriciarzezak@gmail.com.
authors.forename: Patricia
authors.initials: P
authors.lastname: Rzezak
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil.
authors.forename: Sylvie P
authors.initials: SP
authors.lastname: Moschetta
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil.
authors.forename: Ellen
authors.initials: E
authors.lastname: Lima
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil.
authors.forename: Carolina X L
authors.initials: CX
authors.lastname: Castro
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil; Laboratory of Neuroimaging in Psychiatry, Clinics Hospital, University of Sao Paulo (USP), Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo (USP), Brazil.
authors.forename: Silvia
authors.initials: S
authors.lastname: Vincentiis
authors.affiliation: Department of Neurology, University of Campinas (UNICAMP), Brazil.
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Coan
authors.affiliation: Department of Neurology, University of Campinas (UNICAMP), Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Guerreiro
authors.affiliation: Laboratory of Neuroimaging in Psychiatry, Clinics Hospital, University of Sao Paulo (USP), Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo (USP), Brazil.
authors.forename: Geraldo Busatto
authors.initials: GB
authors.lastname: Filho
authors.affiliation: Group for the Study of Cognitive and Psychiatric Disorders in Epilepsy, Clinics Hospital, University of Sao Paulo (USP), Brazil; Laboratory of Neuroimaging in Psychiatry, Clinics Hospital, University of Sao Paulo (USP), Brazil; Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo (USP), Brazil.
authors.forename: Kette D
authors.initials: KD
authors.lastname: Valente
mesh_terms: D000328:Adult; D004833:Epilepsy, Temporal Lobe / Q000523:psychology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020190:Myoclonic Epilepsy, Juvenile / Q000523:psychology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Barratt Impulsiveness Scale; Impulsivity; Juvenile myoclonic epilepsy; Temporal lobe epilepsy