title: Evaluation of advanced oxidation protein products, prooxidant-antioxidant balance, and total antioxidant capacity in untreated vitiligo patients.
abstract: BACKGROUND
  Vitiligo is a chronic, common disease of unknown etiology, and oxidative stress is suggested to have a role in its etiopathogenesis.
  
  
  OBJECTIVE
  Advanced oxidation protein products (AOPPs), prooxidant-antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were evaluated regarding their role in the pathogenesis of vitiligo as well as their relationship with clinical presentation and disease severity, and these parameters were compared with those of healthy controls.
  
  
  METHODS
  The study included 53 patients with vitiligo and 20 healthy volunteers as the control group. AOPP level, PAB, and FRAP were determined by colorimetric methods.
  
  
  RESULTS
  PAB and FRAP level were significantly higher in patients with vitiligo than in healthy controls (p<0.001). The AOPP levels in vitiligo patients were not statistically significantly higher than those in healthy controls. The Vitiligo Area Scoring Index positively correlated with disease duration (rs: 0.531, p<0.001).
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first report of AOPP and PAB status in vitiligo. PAB may be used as an indicator for oxidative stress in the etiopathogenesis of vitiligo. Our results show that these parameters may play a major role in the melanocyte damage observed in vitiligo. Further studies are required to confirm the mechanisms underlying this effect.
authors.affiliation: Kırklareli University, School of Health, Kırklareli, İstanbul, Turkey.
authors.forename: Gülcan
authors.initials: G
authors.lastname: Güntaş
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Burhan
authors.initials: B
authors.lastname: Engin
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Medical Biochemistry, İstanbul University, İstanbul, Turkey.
authors.forename: Özlem Balcı
authors.initials: ÖB
authors.lastname: Ekmekçi
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Zekayi
authors.initials: Z
authors.lastname: Kutlubay
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Medical Biochemistry, İstanbul University, İstanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ekmekci
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Songür
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Tuğba Kevser Üstünbaş
authors.initials: TK
authors.lastname: Uzunçakmak
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Medical Biostatistics, İstanbul University, İstanbul, Turkey.
authors.forename: Hayriye Ertem
authors.initials: HE
authors.lastname: Vehid
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Server
authors.initials: S
authors.lastname: Serdaroğlu
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, İstanbul, Turkey.
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Tüzün
authors.affiliation: Cerrahpaşa Medical Faculty, Department of Medical Biochemistry, İstanbul University, İstanbul, Turkey.
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
keywords: Advanced oxidation protein products; Ferric-reducing antioxidant power; Prooxidant-antioxidant balance; Vitiligo
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