title: [Indication-Related Effectivity of Cervical Occlusion Techniques in Women with Threatening Preterm Birth].
abstract: The aim of this study was to identify which operation technique [total cervical occlusion (TMV), cerclage (C) or combination of both (TMV+C)] would lead to the greatest pregnancy prolongation in 3 different collectives of patients at risk (history of preterm birth, cervical insufficiency, prolapsing membranes). In this retrospective data collection, 200 cervical occlusions performed between 1997 and 2010 were analysed. In patients with a history of preterm birth/stillbirth (n=80) a prophylactic TMV increased the lifebirth rate from 35% without TMV to 95% with TMV (p<0.001). The risk diminuation after TMV was - 60% for stillbirth (p<0.001) and - 30% for preterm birth (p=0.01). In this subcollective the TMV seemed to be more effective in pregnancy prolongation (days) than C (139 vs. 113 days), however the combination of both (C+TMV) did not add much benefit (142 days). In patients with cervical insuffiency (n=86) the pregnancy could be prolonged by 82 (C), 79 (TMV) und 109 days (C+TMV) (p=0.003-0.017) and in patients with membrane prolaps (n=34) by 63 (C), 61 (TMV) und 76 (C+TMV) days. According to present data, the combination of cerclage and TMV has the highest benefit on pregnancy prolongation. This analysis should provide a basis for randomised controlled studies on this topic.
authors.affiliation: Frauenklinik, Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: F
authors.initials: F
authors.lastname: Ohnolz
authors.affiliation: Institut für medizinische Statistik und Epidemiologie, Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: K T M
authors.initials: KT
authors.lastname: Schneider
authors.affiliation: Institut für medizinische Statistik und Epidemiologie, Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: B
authors.initials: B
authors.lastname: Haller
authors.affiliation: Frauenklinik, Klinikum rechts der Isar der Technischen Universität München, München.
authors.forename: B
authors.initials: B
authors.lastname: Kuschel
mesh_terms: D000328:Adult; D023802:Cerclage, Cervical / Q000401:mortality / Q000706:statistics & numerical data*; D003131:Combined Modality Therapy / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D050498:Live Birth / Q000453:epidemiology*; D054238:Perinatal Mortality; D011247:Pregnancy; D047928:Premature Birth / Q000453:epidemiology* / Q000517:prevention & control*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult