title: Rates of residual disease with close but negative margins in breast cancer surgery.
abstract: OBJECTIVE
  A recent multidisciplinary consensus defined an adequate breast cancer margin as no ink on tumor. The purpose of this study was to analyze rates of residual disease at re-excision by margin width.
  
  
  METHODS
  A prospective database at a single institution was reviewed from 2000 to 2012. Institutional protocol had been to perform re-excision surgery when margins were <2 millimeters (mm).
  
  
  RESULTS
  There were 2520 procedures. Re-excision surgery was performed for 12% of breast conserving therapy (BCT) procedures and 2% of mastectomies; residual disease was present in 38% and 26%, respectively. The rates of residual disease for all patients with positive, 0.1-0.9 mm, and 1.0-1.9 mm margins were 40%, 38%, and 33%, respectively. Age, race, menopause status, width of closest final margin, tumor histology, hormone receptor status, triple-negative disease and presence of lymphovascular invasion (LVI) were not significantly associated with the presence of residual disease. The presence of multiple margins <2 mm trended toward significance (p = 0.06). Median follow-up was 43 months. The five-year local recurrence rates (5-year LR) were 1.1% for mastectomy patients and 1.9% for BCT patients.
  
  
  CONCLUSIONS
  Breast cancer patients with margins of excision <2 mm have a substantial risk of residual disease but the rates far exceed LR rates. These findings suggest that using residual disease rates to determine the appropriate margin width is not reliable, but also serve as a note of caution to track LR rates as institutions conform to new national guidelines for margin management.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Erin M
authors.initials: EM
authors.lastname: Garvey
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Senior
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Pockaj
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA.
authors.forename: Nabil
authors.initials: N
authors.lastname: Wasif
authors.affiliation: Section of Biostatistics, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Amylou C
authors.initials: AC
authors.lastname: Dueck
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Ann E
authors.initials: AE
authors.lastname: McCullough
authors.affiliation: Department of Pathology and Laboratory Medicine, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Idris T
authors.initials: IT
authors.lastname: Ocal
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA. Electronic address: Gray.Richard@mayo.edu.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gray
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024221:Antineoplastic Protocols; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D011446:Prospective Studies; D012086:Reoperation
keywords: Breast cancer surgery; Breast conserving therapy; Local recurrence; Margins; Mastectomy; Residual disease