title: Animal models of Epstein Barr virus infection.
abstract: Epstein Barr virus (EBV) was the first human tumor virus to be described. Despite its discovery now more than fifty years ago, immune control of this virus is still not very well understood and no vaccine is available. This knowledge gap is due in part to the lack of a preclinical small animal model which can faithfully recapitulate EBV infection and immune control, and would allow testing of EBV specific vaccine candidates. With the advent of mice with reconstituted human immune system compartments (HIS mice) during the past decade this is changing. We will discuss which aspects of EBV infection and its immune control can already be modeled in HIS mice, and which shortcomings still need to be overcome in order to recapitulate the immunobiology of oncogenic EBV infection.
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Gujer
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
authors.forename: Bithi
authors.initials: B
authors.lastname: Chatterjee
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Landtwing
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
authors.forename: Ana
authors.initials: A
authors.lastname: Raykova
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland.
authors.forename: Donal
authors.initials: D
authors.lastname: McHugh
authors.affiliation: Viral Immunobiology, Institute for Experimental Immunology, University of Zürich, Switzerland. Electronic address: christian.muenz@uzh.ch.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology