title: Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma.
authors.affiliation: Sterna Biologicals GmbH, Marburg, Germany.
authors.forename: Ursula
authors.initials: U
authors.lastname: Homburg
authors.affiliation: Institute of Laboratory Medicine and Pathobiochemistry-Molecular Diagnostics, Medical Faculty, Philipps University Marburg, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Renz
authors.affiliation: Private Consultant, Munich, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Timmer
authors.affiliation: Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
authors.forename: Jens M
authors.initials: JM
authors.lastname: Hohlfeld
authors.affiliation: CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany.
authors.forename: Friedeborg
authors.initials: F
authors.lastname: Seitz
authors.affiliation: Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Lüer
authors.affiliation: CRS Clinical Research Services Mannheim GmbH, Mannheim, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Mayer
authors.affiliation: Engelhard Arzneimittel GmbH, Niederdorfelden, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Wacker
authors.affiliation: Engelhard Arzneimittel GmbH, Niederdorfelden, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Schmidt
authors.affiliation: Sterna Biologicals GmbH, Marburg, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Kuhlmann
authors.affiliation: Sterna Biologicals GmbH, Marburg, Germany.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Turowska
authors.affiliation: Vectura GmbH, Gauting, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Roller
authors.affiliation: AccelPharm, Basel, Switzerland.
authors.forename: Klaus
authors.initials: K
authors.lastname: Kutz
authors.affiliation: Private Consultant, Wuppertal, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schlüter
authors.affiliation: Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Krug
authors.affiliation: Institute of Laboratory Medicine and Pathobiochemistry-Molecular Diagnostics, Medical Faculty, Philipps University Marburg, Universities of Giessen and Marburg Lung Center (UGMLC), Marburg, Germany. Electronic address: garn@staff.uni-marburg.de.
authors.forename: Holger
authors.initials: H
authors.lastname: Garn
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019540:Area Under Curve; D001249:Asthma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D021881:DNA, Catalytic / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005541:Forced Expiratory Volume; D050990:GATA3 Transcription Factor / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D012333:RNA, Messenger / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D014797:Vital Capacity
chemical_list: D018927:Anti-Asthmatic Agents; D021881:DNA, Catalytic; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D012333:RNA, Messenger