title: Quality compared to quantity of life in laryngeal cancer: A time trade-off study.
abstract: The purpose of this study was to use time trade-off to assess the factors influencing patients' decisions in advanced laryngeal cancer. Time trade-off is a well-established method of assessing how individuals value a particular health state.
  
  
  
  We developed vignettes depicting life after chemoradiotherapy or laryngectomy. One hundred fourteen participants ranked them, assigned utility values, and rated the importance of survival on treatment choice.
  
  
  
  Chemoradiotherapy was preferred by 62% and laryngectomy by 38%. Chemoradiotherapy optimal outcome had the highest mean utility value (0.64) followed by total laryngectomy optimal outcome (0.56). Total laryngectomy poor outcome (0.33) was equivalent to chemoradiotherapy poor outcome (0.32).The average survival advantage required for a participant to change their preferred choice was 2.1 years.
  
  
  
  The functional treatment outcome had a greater effect on health state utility values than treatment modality. In many individuals, larynx conservation may not be the primary consideration in treatment preference. © 2015 Wiley Periodicals, Inc. Head Neck 38: E631-E637, 2016.
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: David W
authors.initials: DW
authors.lastname: Hamilton
authors.affiliation: Jeroen Bosch Hospital, Hertogenbosch, The Netherlands.
authors.forename: Janneke E
authors.initials: JE
authors.lastname: Bins
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: McMeekin
authors.affiliation: Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Ami
authors.initials: A
authors.lastname: Pedersen
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Steen
authors.affiliation: Institute of Cellular Medicine, Respiratory Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.|Respiratory Medicine Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Anthony
authors.initials: A
authors.lastname: De Soyza
authors.affiliation: Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom.
authors.forename: Richard
authors.initials: R
authors.lastname: Thomson
authors.affiliation: Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Vinidh
authors.initials: V
authors.lastname: Paleri
authors.affiliation: Freeman Hospital, Newcastle upon Tyne, United Kingdom.
authors.forename: Janet A
authors.initials: JA
authors.lastname: Wilson
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy*; D007825:Laryngectomy; D007830:Larynx / Q000601:surgery; D008297:Male; D057240:Patient Preference; D011788:Quality of Life; D016896:Treatment Outcome
keywords: chemoradiotherapy; head and neck neoplasms; laryngeal neoplasms; laryngectomy; larynx