title: Can the height-independent Pottel eGFR equation be used as a screening tool for chronic kidney disease in children?
abstract: Determination of plasma creatinine (Pcr) should be associated to an estimation of glomerular filtration rate (eGFR). Pottel et al. established a height-independent equation, eGFR = 107.3/(Pcr/Q) where Q is the median of Pcr (Pottel-Belgium). The aims were to 1) determine a local height-independent equation (Pottel-Lyon), 2) evaluate the performance of these equations compared to the Schwartz 2009 and Schwartz-Lyon equations, and 3) evaluate the height-independent equations in laboratory routine. Therefore, 1) all first pediatric Pcr determination (December 2009-June 2011) were collected, and median of Pcr was determined for each 1-year age interval (Q-Lyon), 2) GFR was measured (mGFR) in 359 children (438 measures) and compared to eGFR, and 3) all first Pcr determination (January 2012-June 2013) were used to calculate eGFR with the Pottel-Lyon and the Pottel-Belgium equations. Pcr was determined by an IDMS-standardized enzymatic assay. In the population with a mGFR, the Pottel-Lyon and the Schwartz-Lyon showed the best performance (bias, P10 and P30). However, the performance in identifying patients with a mGFR < 75 mL/min/1.73 m(2) was similar for all the studied equations.
  
  
  CONCLUSIONS
  The performance of the height-independent and dependent equations to identify mild renal dysfunction is similar. The height-independent Pottel equation could be proposed as an excellent screening tool for kidney disease when height information is not available. "
  
  
  BACKGROUND
  " • Determination of plasma creatinine in children is rarely associated to an estimation of glomerular filtration rate due to the lack of height information. • Pottel et al. developed a height-independent equation (eGFR = 107.3/(Pcr/Q) where Q is the median of Pcr for each age class. "
  
  
  BACKGROUND
  " • The performance of the height-independent (Pottel) or height-dependent (Schwartz) equations is similar to identify renal dysfunction (GFR < 75 mL/min/1.73 m (2) ) in children. • The height-independent Pottel equation could be an excellent screening tool for kidney disease in a general pediatric laboratory when height information is not available.
authors.affiliation: Exploration Fonctionnelle Rénale, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, Lyon, France, vandreasouza@gmail.com.
authors.forename: Vandréa
authors.initials: V
authors.lastname: De Souza
authors.forename: Hans
authors.initials: H
authors.lastname: Pottel
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Hoste
authors.forename: Olga
authors.initials: O
authors.lastname: Dolomanova
authors.forename: Regine
authors.initials: R
authors.lastname: Cartier
authors.forename: Luciano
authors.initials: L
authors.lastname: Selistre
authors.forename: Bruno
authors.initials: B
authors.lastname: Ranchin
authors.forename: Aoumeur
authors.initials: A
authors.lastname: Hadj-Aïssa
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lemoine
authors.forename: Pierre
authors.initials: P
authors.lastname: Cochat
authors.forename: Laurence
authors.initials: L
authors.lastname: Dubourg
mesh_terms: D000293:Adolescent; D001530:Belgium / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008403:Mass Screening; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D003404:Creatinine
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