title: Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one.
abstract: The neurobiological basis of pathological anxiety and the improvement of its pharmacological treatment are a matter of intensive investigation. Here, using electrophysiological techniques in brain slices from animals of the high anxiety-related behavior (HAB) and normal anxiety-related behavior (NAB) mouse model, we show that basal neurotransmission at ventral hippocampal CA3-CA1 synapses is weaker in HAB compared to NAB mice. We further demonstrate that paired-pulse facilitation (PPF) and long-term potentiation (LTP) at these synapses are more pronounced in slices from HAB animals. Based on previous findings, we also examined whether intranasal delivery of neuropeptide S (NPS), which increasingly emerges as a potential novel treatment option for anxiety symptoms occurring in a variety of diseases like anxiety disorders, posttraumatic stress disorder, and major depression, impacts on the high-anxiety electrophysiological endophenotype in HAB mice. Strikingly, we detected enhanced basal neurotransmission and reduced PPF and LTP in slices from NPS-treated HAB animals. Collectively, our study uncovers a multifaceted high-anxiety neurophysiological endophenotype in the murine ventral hippocampus and provides the first evidence that an intranasally applied neuropeptide can shift such an endophenotype in an anxiety-regulating brain structure towards a "normal"-anxiety one.
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany; Department Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Julien
authors.initials: J
authors.lastname: Dine
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Ionescu
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Charilaos
authors.initials: C
authors.lastname: Avrabos
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Yen
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Landgraf
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Schmidt
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany; Department Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Eder
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects; D055724:Electrophysiological Phenomena / Q000187:drug effects*; D058068:Endophenotypes; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology*; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D051379:Mice; D009479:Neuropeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D009479:Neuropeptides
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