title: Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans.
abstract: The aim of this study was to investigate the phenolic composition of a natural food colourant (G8000™) as well as its effects on plasma markers after 28-day consumption by healthy individuals at a dietary dose (70 g). Parameters of total cholesterol and its fractions, triglycerides and plasma enzymes biomarkers of muscle injury were measured. Major compounds identified in G8000™ by ESI-MS showed the presence of anthocyanins, organic acids, phenolic acids as well as monosaccharides. HDL levels significantly increased from 43 ± 10.2 mg/dL to 95 ± 16.9 mg/dL. LDL levels significantly decreased from 110 ± 40.9 mg/dL to 69 ± 39 mg/dL (p < 0.001). No significant statistical differences (p > 0.05) were observed for total cholesterol, triglycerides and VLDL. After the intake, plasma enzyme CK-MB decreased from 20 ± 12.1 U/L to 10 ± 1.9 U/L while LDH levels increased from 275 ± 124.4 U/L to 317 ± 114.7 U/L (p < 0.005). No significant differences were observed for CK levels. Taken together, dietary intake of natural colourant G8000™ was able to exert beneficial effects on atherosclerosis biomarkers.
authors.affiliation: Departamento de Biociências, Universidade Federal de São Paulo - UNIFESP , Santos, SP , Brazil .
authors.forename: Rogerio Correa
authors.initials: RC
authors.lastname: Peres
authors.forename: Andrea Pitelli Boiago
authors.initials: AP
authors.lastname: Gollücke
authors.forename: Clayton
authors.initials: C
authors.lastname: Soares
authors.forename: Patricia
authors.initials: P
authors.lastname: Machado
authors.forename: Vitor
authors.initials: V
authors.lastname: Viveiros Filho
authors.forename: Silvana
authors.initials: S
authors.lastname: Rocha
authors.forename: Damila Rodrigues
authors.initials: DR
authors.lastname: Morais
authors.forename: Giovana Anceski
authors.initials: GA
authors.lastname: Bataglion
authors.forename: Marcos Nogueira
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005505:Food Coloring Agents / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010636:Phenols / Q000097:blood / Q000494:pharmacology; D010936:Plant Extracts / Q000097:blood* / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D027843:Vitis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005505:Food Coloring Agents; D010636:Phenols; D010936:Plant Extracts; D014280:Triglycerides
keywords: Cardiovascular diseases; grape; natural food colourant; nutraceuticals; plasma injury enzymes; polyphenols