title: Stereogenic α-carbons determine the shape and topology of [13]-macrodilactones.
abstract: The synthesis and characterization of new [13]-macrodilactones substituted at stereogenic centers α- to the carbonyl are reported. When one center is substituted, it directs the topology of the macrocycle; when two centers are substituted, both the shape and the topology are influenced. The findings indicate that the number and configuration of α-centers fine-tune macrocyclic structure.
authors.affiliation: Department of Chemistry, University of Connecticut, 55 North Eagleville Road, U-3060, Storrs, CT 06269, USA. mark.peczuh@uconn.edu.
authors.forename: Anniefer N
authors.initials: AN
authors.lastname: Magpusao
authors.forename: Kelli
authors.initials: K
authors.lastname: Rutledge
authors.forename: Brandon Q
authors.initials: BQ
authors.lastname: Mercado
authors.forename: Mark W
authors.initials: MW
authors.lastname: Peczuh