title: Small RNAs: artificial piRNAs for transcriptional silencing.
abstract: Technologies have been developed in animal germ cells that produce artificial piRNAs from transgenes in piRNA clusters to silence target genes by cleaving their transcripts. A new study provides a simple way to generate artificial piRNAs to direct de novo DNA methylation in mice.
authors.affiliation: Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan.
authors.forename: Takamasa
authors.initials: T
authors.lastname: Hirano
authors.affiliation: Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address: awa403@z2.keio.jp.
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Siomi
mesh_terms: D000818:Animals; D019175:DNA Methylation; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D008297:Male; D034741:RNA, Small Interfering
chemical_list: D034741:RNA, Small Interfering