title: [The effect of leucine and lysine dipeptides on the proliferation of the myocardium and spleen from young and old rats in organotypic culture].
abstract: The effect of new dipeptides consisting from leucine and lysine was investigated in organotypic tissue culture on the cell proliferation development in spleen and myocardium explants in 3- and 24-months old rats. Dipeptide L-Leu-Lys stimulated the cell proliferation in the young and old rats at concentrations 0,001-10 ng/ml and 0,01-1 ng/ml accordingly. Dipeptide L-Lys-Leu stimulated as well the cell proliferation in the young and old rats at some deviation of diapason of stimulating concentrations. The data obtained aboutthe new dipeptides with high biological activity create a basis for future research at the organism level for their application in geriatrics to enhance regenerative processes in lymphoid and myocard tissue.
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: A N
authors.initials: AN
authors.lastname: Zhekalov
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D009206:Myocardium / Q000166:cytology*; D009924:Organ Culture Techniques; D017208:Rats, Wistar; D012038:Regeneration; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
chemical_list: D004151:Dipeptides; C000600949:leucyl-lysine