title: [Local fibrinolytic therapy in complex of surgical treatment of the brain arterial aneurism in acute period of hemorrhagic insult].
abstract: Hemorrhagic insult (HI) with formation of intracranial hemorrhage of various anatomic form constitutes a typical clinical sign of the brain arterial aneurism rupture. Surgical intervention is the only one method of treatment in such patients. Some of them need performance of a one-staged or multi-staged operative interventions, directed on devascularization of the brain arterial aneurisms, evacuation or drainage of intracranial hemorrhage. One of physiological and perspective methods of clinical situation improvement is a local fibrinolytic therapy (LFTH) in complex of surgical treatment of the brain arterial aneurisms. Retrospective cohort investigation was performed in the clinic in 2012 - 2014 yrs on 86 patients with the objective to determine expediency, efficacy and perspective of LFTH application in complex of surgical treatment of the brain arterial aneurisms in acute period of HI. There was established the effectiveness and perspectivity of LFTH in complex of surgical treatment of the brain arterial aneurisms in acute period of HI, not depending on method of its devascularization and positive impact on general results of the patients treatment.
authors.forename: S O
authors.initials: SO
authors.lastname: Lytvak
authors.forename: M V
authors.initials: MV
authors.lastname: Ieleĭnik
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D002536:Cerebral Arteries / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007276:Injections, Intraventricular; D002532:Intracranial Aneurysm / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D020300:Intracranial Hemorrhages / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012422:Rupture, Spontaneous / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator