title: Regulation of hormone-sensitive renal phosphate transport.
abstract: Phosphate is essential for growth and maintenance of the skeleton and for generating high-energy phosphate compounds. Evolutionary adaptation to high dietary phosphorous in humans and other terrestrial vertebrates involves regulated mechanisms assuring the efficient renal elimination of excess phosphate. These mechanisms prominently include PTH, FGF23, and Vitamin D, which directly and indirectly regulate phosphate transport. Disordered phosphate homeostasis is associated with pathologies ranging from kidney stones to kidney failure. Chronic kidney disease results in hyperphosphatemia, an elevated calcium×phosphate product with considerable morbidity and mortality, mostly associated with adverse cardiovascular events. This chapter highlights recent findings and insights regarding the hormonal regulation of renal phosphate transport along with imbalances of phosphate balance due to acquired or inherited diseases states.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: jyothsna.gattineni@utsouthwestern.edu.
authors.forename: Jyothsna
authors.initials: J
authors.lastname: Gattineni
authors.affiliation: Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Friedman
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism*
chemical_list: C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23
keywords: CKD; FGF23; Klotho; Megalin; Npt2a; PDZ proteins; PTH; Vitamin D