title: Prominent Decrease of Tear Meniscus Height With Contact Lens Wear and Efficacy of Eye Drop Instillation.
abstract: OBJECTIVE
  To investigate the change in tear meniscus height (TMH) before and after wearing soft contact lenses (CLs) of different water contents (WCs) and the influence of eye drop instillation on TMH during CL wear.
  
  
  METHODS
  Tear meniscus heights were measured using anterior segment optical coherence tomography in 20 normal subjects wearing a high-WC CL (WC, 69%) in 1 eye and a low-WC CL (WC, 24%) in the other. Tear meniscus height change after eye drop instillation with 3% diquafosol ophthalmic solution or saline with CL wear was evaluated at 5, 15, 30, and 60 min after instillation.
  
  
  RESULTS
  A significant decrease in TMH was observed after lens insertions of both CLs. Tear meniscus height was significantly decreased with high-WC CL wear compared with that with low-WC CL wear. With high-WC CL wear, TMH increased significantly (P<0.001) at 5 min after the instillation of 3% diquafosol ophthalmic solution compared with the baseline values and then returned to the pre-instillation level. No significant TMH changes were found with the instillation of either eye drop (diquafosol or saline) with low-WC CL wear.
  
  
  CONCLUSIONS
  Tear meniscus height decreased with CL wear, especially with high-WC CL wear. Significant increases in TMH were observed at 5 min after the instillation of diquafosol ophthalmic solution with high-WC CL wear. The increases in TMH after diquafosol instillation tended to be greater than those after saline instillation at least for 30 min with both high-WC and low-WC CLs.
authors.affiliation: Department of Ophthalmology (Y.N., S.K., N.M., K.N., H.W.), Osaka University Graduate School of Medicine, Suita, Osaka, Japan; and Department of Ophthalmology (H.W.), Kansai Rosai Hospital, Amagasaki, Hyogo, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Nagahara
authors.forename: Shizuka
authors.initials: S
authors.lastname: Koh
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D015352:Dry Eye Syndromes / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D011122:Polyphosphates / Q000008:administration & dosage*; D013666:Tears / Q000187:drug effects / Q000378:metabolism; D041623:Tomography, Optical Coherence / Q000379:methods; D014500:Uracil Nucleotides / Q000008:administration & dosage*
chemical_list: D009883:Ophthalmic Solutions; D011122:Polyphosphates; D014500:Uracil Nucleotides; C403315:diquafosol