title: RASSF1A gene methylation is associated with nasopharyngeal carcinoma risk in Chinese.
abstract: In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.
authors.affiliation: Medical Faculty, Kunming University of Science and Technology, Kunming, Yunnan, P.R. China E-mail : txd06@163.com.
authors.forename: Kun
authors.initials: K
authors.lastname: Wu
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Pu
authors.forename: Bo-Yuan
authors.initials: BY
authors.lastname: Wang
authors.forename: Xiao-Dan
authors.initials: XD
authors.lastname: Tang
mesh_terms: D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D019175:DNA Methylation; D006801:Humans; D015201:Meta-Analysis as Topic; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C411762:RASSF1 protein, human; D025521:Tumor Suppressor Proteins