title: An update on the transport and metabolism of iron in Listeria monocytogenes: the role of proteins involved in pathogenicity.
abstract: Listeria monocytogenes is a Gram-positive bacterium that causes a rare but severe human disease with high mortality rate. The microorganism is widespread in the natural environment where it shows a saprophytic lifestyle. In the human body it infects many different cell types, where it lives intracellularly, however it may also temporarily live extracellularly. The ability to survive and grow in such diverse niches suggests that this bacterium has a wide range of mechanisms for both the acquisition of various sources of iron and effective management of this microelement. In this review, data about the mechanisms of transport, metabolism and regulation of iron, including recent findings in these areas, are summarized with focus on the importance of these mechanisms for the virulence of L. monocytogenes. These data indicate the key role of haem transport and maintenance of intracellular iron homeostasis for the pathogenesis of L. monocytogenes. Furthermore, some of the proteins involved in iron homeostasis like Fri and FrvA seem to deserve special attention due to their potential use in the development of new therapeutic antilisterial strategies.
authors.affiliation: Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096, Warsaw, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Lechowicz
authors.forename: Agata
authors.initials: A
authors.lastname: Krawczyk-Balska
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D001692:Biological Transport; D007501:Iron / Q000378:metabolism*; D008089:Listeria monocytogenes / Q000737:chemistry / Q000378:metabolism* / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D007501:Iron
references.citation: Infect Immun. 1998 Feb;66(2):747-55
references.pmid: 9453636
references.citation: Infect Immun. 1998 Aug;66(8):3758-66
references.pmid: 9673259
references.citation: Biochem Biophys Res Commun. 1998 Aug 19;249(2):526-30
references.pmid: 9712730
references.citation: Infect Immun. 1999 Jan;67(1):182-6
references.pmid: 9864213
references.citation: Adv Microb Physiol. 1998;40:281-351
references.pmid: 9889981
references.citation: J Bacteriol. 1999 Oct;181(20):6223-9
references.pmid: 10515908
references.citation: Mol Microbiol. 2005 Feb;55(3):927-40
references.pmid: 15661014
references.citation: Microbiology. 2005 Mar;151(Pt 3):925-33
references.pmid: 15758237
references.citation: Curr Opin Microbiol. 2005 Apr;8(2):174-81
references.pmid: 15802249
references.citation: Biochemistry. 2005 Apr 19;44(15):5572-8
references.pmid: 15823015
references.citation: Annu Rev Biochem. 2005;74:247-81
references.pmid: 15952888
references.citation: FEMS Microbiol Lett. 2005 Sep 15;250(2):253-61
references.pmid: 16098690
references.citation: Can J Microbiol. 2005 Sep;51(9):745-51
references.pmid: 16391652
references.citation: Mol Microbiol. 2006 Feb;59(4):1185-98
references.pmid: 16430693
references.citation: IUBMB Life. 2005 Nov;57(11):749-59
references.pmid: 16511968
references.citation: Infect Immun. 2006 Apr;74(4):2215-23
references.pmid: 16552052
references.citation: FEMS Immunol Med Microbiol. 2006 Apr;46(3):330-9
references.pmid: 16553805
references.citation: Mol Genet Genomics. 2006 Apr;275(4):344-53
references.pmid: 16528570
references.citation: Infect Immun. 2006 Jun;74(6):3687-91
references.pmid: 16714605
references.citation: Biometals. 2006 Apr;19(2):143-57
references.pmid: 16718600
references.citation: Infect Immun. 2006 Jul;74(7):3987-4001
references.pmid: 16790772
references.citation: Science. 2004 Sep 10;305(5690):1626-8
references.pmid: 15361626
references.citation: Contrib Microbiol. 2005;12:210-33
references.pmid: 15496782
references.citation: J Cell Biol. 1989 Oct;109(4 Pt 1):1597-608
references.pmid: 2507553
references.citation: Infect Immun. 1990 Aug;58(8):2715-8
references.pmid: 2115028
references.citation: J Bacteriol. 1992 Jan;174(2):568-74
references.pmid: 1729245
references.citation: EMBO J. 1992 May;11(5):1981-90
references.pmid: 1582425
references.citation: FEMS Microbiol Lett. 1993 Apr 15;108(3):311-8
references.pmid: 8514118
references.citation: J Bacteriol. 1993 Sep;175(17):5428-37
references.pmid: 8396117
references.citation: Infect Immun. 1994 Sep;62(9):4091-4
references.pmid: 8063432
references.citation: Mol Microbiol. 1994 Dec;14(5):843-50
references.pmid: 7715446
references.citation: Biometals. 1995 Apr;8(2):129-36
references.pmid: 7734925
references.citation: Appl Environ Microbiol. 1995 Apr;61(4):1643-5
references.pmid: 7747980
references.citation: Microbiology. 1995 Aug;141 ( Pt 8):1985-92
references.pmid: 7551061
references.citation: J Bacteriol. 1995 Dec;177(24):7186-93
references.pmid: 8522527
references.citation: Cell. 1996 Mar 22;84(6):923-32
references.pmid: 8601315
references.citation: Arch Microbiol. 1996 Jul;166(1):51-7
references.pmid: 8661944
references.citation: Infect Immun. 1997 Jul;65(7):2778-85
references.pmid: 9199450
references.citation: Res Microbiol. 1996 Nov-Dec;147(9):677-85
references.pmid: 9296102
references.citation: Mol Microbiol. 2007 Mar;63(5):1495-507
references.pmid: 17302823
references.citation: J Mol Biol. 2008 Jan 25;375(4):1086-97
references.pmid: 18068722
references.citation: Microbiol Mol Biol Rev. 2008 Mar;72(1):110-25, table of contents
references.pmid: 18322036
references.citation: J Bacteriol. 2008 May;190(10):3588-96
references.pmid: 18326576
references.citation: Future Microbiol. 2008 Jun;3(3):287-98
references.pmid: 18505395
references.citation: PLoS Pathog. 2011 Nov;7(11):e1002356
references.pmid: 22072970
references.citation: J Biol Chem. 2012 Feb 10;287(7):4752-8
references.pmid: 22084241
references.citation: PLoS One. 2012;7(2):e30928
references.pmid: 22363518
references.citation: Mol Membr Biol. 2012 May-Jun;29(3-4):69-86
references.pmid: 22703022
references.citation: Cold Spring Harb Perspect Med. 2012 Nov;2(11). pii: a010009. doi: 10.1101/cshperspect.a010009
references.pmid: 23125201
references.citation: BMC Microbiol. 2012;12:278
references.pmid: 23176286
references.citation: J Med Microbiol. 2013 Feb;62(Pt 2):185-90
references.pmid: 23105022
references.citation: PLoS One. 2013;8(2):e56529
references.pmid: 23437157
references.citation: Biochim Biophys Acta. 2013 Oct;1833(10):2267-78
references.pmid: 23764491
references.citation: Front Cell Infect Microbiol. 2013;3:59
references.pmid: 24106689
references.citation: PLoS One. 2013;8(10):e77808
references.pmid: 24204978
references.citation: Acta Crystallogr D Biol Crystallogr. 2014 Mar;70(Pt 3):615-26
references.pmid: 24598731
references.citation: Adv Microb Physiol. 2014;65:83-123
references.pmid: 25476765
references.citation: J Biol Chem. 2014 Dec 12;289(50):34886-99
references.pmid: 25315777
references.citation: Microbiology. 2015 Feb;161(Pt 2):264-71
references.pmid: 25416690
references.citation: Arch Microbiol. 2015 Mar;197(2):347-51
references.pmid: 25352185
references.citation: BMC Biochem. 2009;10:3
references.pmid: 19187533
references.citation: Nature. 2009 Jun 18;459(7249):950-6
references.pmid: 19448609
references.citation: J Bacteriol. 2009 Oct;191(19):5921-9
references.pmid: 19633084
references.citation: Bioessays. 2009 Dec;31(12):1309-17
references.pmid: 19877004
references.citation: Appl Environ Microbiol. 2010 Jan;76(2):406-16
references.pmid: 19933349
references.citation: Cell Mol Life Sci. 2010 Feb;67(3):341-51
references.pmid: 19826764
references.citation: Infect Immun. 2010 Jul;78(7):3306-14
references.pmid: 20439472
references.citation: J Biol Chem. 2010 Aug 20;285(34):25978-86
references.pmid: 20543190
references.citation: J Bacteriol. 2010 Sep;192(18):4606-17
references.pmid: 20639324
references.citation: Infect Immun. 2010 Dec;78(12):4977-89
references.pmid: 20679437
references.citation: Curr Opin Chem Biol. 2011 Apr;15(2):260-6
references.pmid: 21339081
references.citation: Mol Microbiol. 2011 Jun;80(6):1581-97
references.pmid: 21545655
references.citation: Annu Rev Microbiol. 2011;65:129-47
references.pmid: 21639791
references.citation: Cell. 2000 Oct 27;103(3):501-10
references.pmid: 11081636
references.citation: Mol Microbiol. 2001 May;40(3):572-85
references.pmid: 11359564
references.citation: Clin Microbiol Rev. 2001 Jul;14(3):584-640
references.pmid: 11432815
references.citation: Science. 2001 Oct 26;294(5543):849-52
references.pmid: 11679669
references.citation: Microbiology. 2002 Aug;148(Pt 8):2273-82
references.pmid: 12177321
references.citation: Microbes Infect. 2002 Sep;4(11):1149-56
references.pmid: 12361915
references.citation: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16243-8
references.pmid: 12446835
references.citation: J Bacteriol. 2003 Feb;185(3):1010-7
references.pmid: 12533477
references.citation: FEMS Microbiol Rev. 2003 Jun;27(2-3):215-37
references.pmid: 12829269
references.citation: J Bacteriol. 2003 Nov;185(21):6295-307
references.pmid: 14563864
references.citation: J Bacteriol. 2004 Apr;186(7):1972-82
references.pmid: 15028680
references.citation: J Bacteriol. 2004 Jun;186(11):3578-89
references.pmid: 15150246