title: Gangliocytic paraganglioma: a rare cause of gastrointestinal bleeding.
abstract: Duodenal neuroendocrine tumors (NETs) are rare tumors, consisting of five different types of tumors. In many cases, they may be asymptomatic, leading to delay in diagnosis. Clinical symptoms are related to local tumor growth and mucosal ulceration. We report a 38-year old man with duodenal gangliocytic paraganglioma causing overt upper gastrointestinal bleeding and anemia. We describe specific clinical and histopathological features of the tumor, and review the diagnostic and therapeutic strategy. Gangliocytic paragangliomas are regarded as benign tumors. However, the disease recurrence and the malignant potential of the tumor have also been reported.
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu Mures, Romania.
authors.forename: Alina
authors.initials: A
authors.lastname: Boeriu
authors.affiliation: Department of Gastroenterology, University of Medicine and Pharmacy, Târgu Mures, Romania.
authors.forename: Daniela
authors.initials: D
authors.lastname: Dobru
authors.affiliation: Department of Surgery, University of Medicine and Pharmacy Targu Mures, Romania.
authors.forename: Rareș
authors.initials: R
authors.lastname: Georgescu
authors.affiliation: Department of Pathology, Targu Mures County Emergency Hospital, Romania.
authors.forename: Simona
authors.initials: S
authors.lastname: Mocan
authors.affiliation: Emergency Department, University of Medicine and Pharmacy, Târgu Mures Romania. cboeriu@gmail.com.
authors.forename: Cristian
authors.initials: C
authors.lastname: Boeriu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004379:Duodenal Neoplasms / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D004384:Duodenoscopy; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010235:Paraganglioma / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D011237:Predictive Value of Tests
chemical_list: D014408:Biomarkers, Tumor