title: A Major Human White Matter Pathway Between Dorsal and Ventral Visual Cortex.
abstract: Human visual cortex comprises many visual field maps organized into clusters. A standard organization separates visual maps into 2 distinct clusters within ventral and dorsal cortex. We combined fMRI, diffusion MRI, and fiber tractography to identify a major white matter pathway, the vertical occipital fasciculus (VOF), connecting maps within the dorsal and ventral visual cortex. We use a model-based method to assess the statistical evidence supporting several aspects of the VOF wiring pattern. There is strong evidence supporting the hypothesis that dorsal and ventral visual maps communicate through the VOF. The cortical projection zones of the VOF suggest that human ventral (hV4/VO-1) and dorsal (V3A/B) maps exchange substantial information. The VOF appears to be crucial for transmitting signals between regions that encode object properties including form, identity, and color and regions that map spatial information.
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Takemura
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.
authors.forename: Ariel
authors.initials: A
authors.lastname: Rokem
authors.affiliation: Department of Psychology, New York University, New York, NY, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Winawer
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.|Institute for Learning and Brain Science (ILABS), University of Washington, Seattle, WA, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Yeatman
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Wandell
authors.affiliation: Department of Psychology, Stanford University, Stanford, CA, USA.|Department of Psychological and Brain Sciences, Programs in Neuroscience and Cognitive Science, Indiana University, Bloomington, IN, USA.
authors.forename: Franco
authors.initials: F
authors.lastname: Pestilli
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008297:Male; D014793:Visual Cortex / Q000033:anatomy & histology*; D014794:Visual Fields; D014795:Visual Pathways / Q000033:anatomy & histology*; D066127:White Matter / Q000033:anatomy & histology*
keywords: diffusion-weighted MRI; fiber tractography; vertical occipital fasciculus; visual cortex; white matter
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