title: Endostar combined with chemotherapy compared with chemotherapy alone in the treatment of nonsmall lung carcinoma: A meta-analysis based on Chinese patients.
abstract: BACKGROUND
  Lung cancer is the leading cause of cancer-associated death world-wide. And the lung cancer is generally divided into small cell lung carcinoma and non-small cell lung cancer. For advanced NSCLC, the chemotherapy and target therapy were the important treatment modality. This meta-analysis was to evaluate the clinical efficacy and toxicity between endostar combined chemotherapy and chemotherapy alone in Chinese patients.
  
  
  METHODS
  We searched the PubMed, EMBASE, and CNKI databases to find the potential relevant articles reporting the endostar combined with chemotherapy regimen in the treatment of nonsmall cell lung cancer in Chinese patients. The tumor response and toxicity difference between the two groups were demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). All the data was pooled by Stata 11.0 (http://www.stata.com; Stata Corporation, College Station, TX) software.
  
  
  RESULTS
  We included 14 studies published in Chinese or English studies. The pooled results showed adding endostar in the chemotherapy regimen can significant increase the objective response rate (OR = 2.42, 95% CI = 1.87-3.12, P = 0.00) and disease control rate (OR = 2.22, 95% CI = 1.68-2.94, P = 0.00). For toxicities, the pooled data showed no statistical difference for grade III-IV granulocytopenia risk (OR = 1.04, 95% CI = 0.74-1.44, P = 0.83). Nausea and vomiting (OR = 0.93 95% CI: 0.51-1.52, P = 0.78) and grade III-IV alopecia (OR = 0.99, 95% CI: 0.76-1.29, P = 0.95). The funnel plot showed no statistical publications.
  
  
  CONCLUSIONS
  Combined treatment with endostar can improve the response rate for NSCLC patients without increasing the risk of developing severe adverse event.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: L J
authors.initials: LJ
authors.lastname: Gu
authors.forename: C X
authors.initials: CX
authors.lastname: Fu
authors.forename: Z
authors.initials: Z
authors.lastname: Cao
authors.affiliation: Department of Resporatory, Lishui People's Hospital, Lishui 321400, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Chen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D044466:Asian People; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D003131:Combined Modality Therapy; D043169:Endostatins / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism*; D015316:Genetic Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D011379:Prognosis; D011994:Recombinant Proteins
chemical_list: D043169:Endostatins; D011994:Recombinant Proteins; C522911:endostar protein