title: Changes in bone mineral density following long-term simultaneous pancreas-kidney transplantation.
abstract: The symptoms of chronic renal disease-related mineral and bone disease improve significantly in patients after successful simultaneous pancreas-kidney transplantation (SPKT); however, bone pathology is still present even after many post-transplant years. The aim of this study was to analyze the bone densitometry in different periods after SPKT. Three-point densitometry was performed with the dual-energy X-ray absorptiometry (DXA) technique. Serum levels of alkaline phosphatase (ALP), total serum calcium, phosphate and parathyroid hormone were analyzed as markers of mineral metabolism. The study population consisted of 48 patients (28 females, 20 males) with a mean age of 35 ± 6 years and mean 24 ± 6 years of prior diabetes. Mean period of maintenance dialysis was 36 ± 26 months. The median time from SPKT and DXA measurement was 0.53, 26.2 and 41.9 months, respectively. Based on the DXA technique, 35.4 % of patients were categorized as having osteoporosis at the lumbar spine and 39.6 % at the femoral neck. Patients with diagnosed osteoporosis had significantly higher levels of ALP (OR = 1.5; 95 % CI = 1.1-2.2; p < 0.05 at the lumbar spine; OR = 1.4; 95 % CI = 1.0-1.9; p < 0.05 at the femoral neck). In addition, subjects with lumbar osteoporosis were characterized by a significantly lower body mass index (BMI) (OR = 0.5; 95 % CI = 0.3-0.9; p < 0.05). In the long-term follow-up, BMD increased significantly at the lumbar spine (T-score -1.86 ± 1.07 to -1.08 ± 0.89) and femoral neck (T-score -2.12 ± 0.78 to -1.63 ± 0.65). A multivariate linear model identified a BMI increase as a significant factor associated with improvement in BMD. Results of our study led us to conclude that, according to three-point densitometry, BMD among patients with functioning kidney and pancreas grafts improved. Increased serum levels of ALP were significantly associated with a decrease in BMD, suggesting a higher risk of osteoporosis. BMI gain was predictive of BMD improvement.
authors.affiliation: Department of Nephrology, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal. acrisbraga@gmail.com.
authors.forename: Ana
authors.initials: A
authors.lastname: Rocha
authors.affiliation: Department of Nephrology, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.
authors.forename: La Salete
authors.initials: LS
authors.lastname: Martins
authors.affiliation: Department of Nephrology, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.
authors.forename: Jorge
authors.initials: J
authors.lastname: Malheiro
authors.affiliation: Department of Endocrinology, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Jorge
authors.initials: J
authors.lastname: Dores
authors.affiliation: Department of Nephrology, Centro Hospitalar de Gaia e Espinho, Espinho, Portugal.
authors.forename: Clara
authors.initials: C
authors.lastname: Santos
authors.affiliation: Department of Nephrology, Centro Hospitalar do Porto, Largo Prof. Abel Salazar, 4099-001, Porto, Portugal.
authors.forename: Castro
authors.initials: C
authors.lastname: Henriques
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006801:Humans; D016030:Kidney Transplantation; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D015999:Multivariate Analysis; D010024:Osteoporosis / Q000503:physiopathology; D016035:Pancreas Transplantation; D011239:Prednisolone / Q000627:therapeutic use; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D011239:Prednisolone
keywords: Alkaline phosphatase; Body mass index; Bone mineral density; Osteoporosis; Simultaneous pancreas-kidney transplantation
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