title: Evolutionary dynamics of metazoan TRP channels.
abstract: Transient receptor potential (TRP) channels are unusual among cation channels because of their diverse cation selectivities and activation mechanisms. TRP channels thus play major roles in various sensory perceptions by functioning as multimodal signal integrators. Some TRP subfamily members are also implicated in acute and chronic pain and inflammation. So far, most TRP channel studies have been targeted to human and model organisms within a limited evolutionary context. Classification of TRP channels in various animal genomes has revealed extensive gene gain and loss events across animal species. Furthermore, the chemical activation profiles of some orthologous TRP channels were different between species such as human and mouse. Amino acid substitutions must underlie such differences, and the crucial amino acid residues have been identified in some cases. These changes represent the evolution of TRP channels at the amino acid sequence level. There is also evidence that TRP channels have obtained species-diversity through alternative splicing and possibly cis-regulatory element mutations. All of the above demonstrate the dynamic and plastic evolutionary history of metazoan TRP channels at multiple levels, possibly in conjunction with the specific habitats and life histories of individual species.
authors.affiliation: Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, 111 Ren'ai Road, Dushu Lake Higher Education Town, Suzhou, Jiangsu Province, 215123, China. Tatsuhiko.Kadowaki@xjtlu.edu.cn.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D012326:RNA Splicing; D050051:Transient Receptor Potential Channels / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: D050051:Transient Receptor Potential Channels
keywords: Amino acid substitution; Animal genomes; Evolution; Gene loss/gain; Pre-mRNA splicing; TRP channel; cis-regulatory mutations
references.citation: Biochem J. 2014 Aug 15;462(1):15-24
references.pmid: 25057889
references.citation: Cell Calcium. 2015 Mar;57(3):214-21
references.pmid: 25533790
references.citation: J Biol Chem. 2012 Aug 31;287(36):30743-54
references.pmid: 22791718
references.citation: Biochim Biophys Acta. 2007 Aug;1772(8):851-8
references.pmid: 17306511
references.citation: J Biol Chem. 2004 May 7;279(19):20283-95
references.pmid: 14996838
references.citation: Nature. 2008 Aug 21;454(7207):955-60
references.pmid: 18719581
references.citation: Nat Chem Biol. 2007 Mar;3(3):174-82
references.pmid: 17293875
references.citation: BMC Evol Biol. 2014 Jan 13;14:3
references.pmid: 24410880
references.citation: Nat Genet. 2005 Mar;37(3):305-10
references.pmid: 15731759
references.citation: Cell Rep. 2012 Jan 26;1(1):43-55
references.pmid: 22347718
references.citation: Nature. 2010 Mar 25;464(7288):597-600
references.pmid: 20237474
references.citation: Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7801-5
references.pmid: 11427713
references.citation: Nat Rev Genet. 2011 Dec 06;13(1):59-69
references.pmid: 22143240
references.citation: BMC Evol Biol. 2009 Sep 10;9:228
references.pmid: 19740447
references.citation: Nat Genet. 2005 Jul;37(7):739-44
references.pmid: 15924139
references.citation: Cell. 2002 Feb 8;108(3):421-30
references.pmid: 11853675
references.citation: BMC Genomics. 2006 Jun 20;7:159
references.pmid: 16787531
references.citation: Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1249-55
references.pmid: 24639527
references.citation: Am J Hum Genet. 2009 Nov;85(5):711-9
references.pmid: 19878917
references.citation: Am J Hum Genet. 2009 Nov;85(5):720-9
references.pmid: 19896113
references.citation: Annu Rev Biochem. 2007;76:387-417
references.pmid: 17579562
references.citation: Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13606-11
references.pmid: 19666538
references.citation: J Neurosci. 2010 Sep 15;30(37):12219-29
references.pmid: 20844118
references.citation: Curr Biol. 2011 Apr 12;21(7):592-7
references.pmid: 21458266
references.citation: J Cell Biol. 2002 Jan 7;156(1):29-34
references.pmid: 11781332
references.citation: Nat Genet. 2010 Feb;42(2):160-4
references.pmid: 20037588
references.citation: Science. 2003 Jul 4;301(5629):96-9
references.pmid: 12805553
references.citation: J Biol Chem. 2004 Sep 3;279(36):37423-30
references.pmid: 15234965
references.citation: Nature. 2013 Jan 10;493(7431):221-5
references.pmid: 23222543
references.citation: J Neurosci. 2008 Sep 24;28(39):9640-51
references.pmid: 18815250
references.citation: Nat Genet. 2010 Feb;42(2):165-9
references.pmid: 20037587
references.citation: Biophys J. 2010 Dec 1;99(11):3609-18
references.pmid: 21112285
references.citation: Nature. 2001 May 31;411(6837):590-5
references.pmid: 11385574
references.citation: Mol Phylogenet Evol. 2015 Mar;84:145-57
references.pmid: 24981559
references.citation: Annu Rev Cell Dev Biol. 2013;29:355-84
references.pmid: 24099085
references.citation: Biol Bull. 2001 Dec;201(3):323-38
references.pmid: 11751245
references.citation: Nature. 2011 Dec 04;481(7379):76-80
references.pmid: 22139422
references.citation: Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1184-91
references.pmid: 21930928
references.citation: Semin Cell Dev Biol. 2006 Dec;17(6):607-17
references.pmid: 17174125
references.citation: Mol Biol Evol. 2012 Jan;29(1):91-100
references.pmid: 21680871
references.citation: Nat Genet. 2010 Feb;42(2):170-4
references.pmid: 20037586
references.citation: J Neurosci. 2007 Sep 12;27(37):9874-84
references.pmid: 17855602
references.citation: Proc Biol Sci. 2013 Oct 07;280(1768):20130959
references.pmid: 23926145
references.citation: Mol Biosyst. 2008 May;4(5):372-9
references.pmid: 18414734
references.citation: Nature. 2010 Aug 5;466(7307):720-6
references.pmid: 20686567
references.citation: Science. 2012 Dec 21;338(6114):1587-93
references.pmid: 23258890
references.citation: Nat Genet. 2002 Jun;31(2):171-4
references.pmid: 12032570
references.citation: Mol Pharmacol. 2009 Jun;75(6):1262-79
references.pmid: 19297520
references.citation: J Neurosci. 2008 May 7;28(19):5063-71
references.pmid: 18463259
references.citation: Nature. 2007 Nov 8;450(7167):294-8
references.pmid: 17994098
references.citation: Neuron. 2010 Jun 10;66(5):671-80
references.pmid: 20547126
references.citation: Mol Biol Evol. 2014 Mar;31(3):708-22
references.pmid: 24398321
references.citation: Nat Commun. 2013;4:2501
references.pmid: 24071625
references.citation: Science. 2005 Jun 17;308(5729):1801-4
references.pmid: 15879175
references.citation: Nature. 2013 Dec 5;504(7478):113-8
references.pmid: 24305161
references.citation: Nature. 2011 Aug 03;476(7358):88-91
references.pmid: 21814281
references.citation: Science. 2001 Feb 9;291(5506):1043-7
references.pmid: 11161216
references.citation: Antonie Van Leeuwenhoek. 2002 Aug;81(1-4):465-80
references.pmid: 12448743
references.citation: Cell. 2014 Jun 5;157(6):1262-78
references.pmid: 24906146
references.citation: Biochim Biophys Acta. 2007 Aug;1772(8):836-50
references.pmid: 17292589
references.citation: Nature. 2013 Dec 5;504(7478):107-12
references.pmid: 24305160
references.citation: Nature. 2003 Jul 3;424(6944):81-4
references.pmid: 12819662
references.citation: Neuron. 2014 Jun 4;82(5):1017-31
references.pmid: 24814535
references.citation: Am J Hum Genet. 2009 Nov;85(5):730-6
references.pmid: 19896109
references.citation: BMC Genomics. 2002;3:3
references.pmid: 11897010
references.citation: Curr Biol. 2008 Sep 23;18(18):R880-9
references.pmid: 18812089
references.citation: Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19564-8
references.pmid: 17164327
references.citation: Genes Brain Behav. 2009 Jul;8(5):546-57
references.pmid: 19531155
references.citation: Mol Biol Evol. 2008 Jul;25(7):1357-61
references.pmid: 18385221
references.citation: J Neurosci. 2013 Jan 16;33(3):894-901
references.pmid: 23325228
references.citation: J Biol Chem. 2005 Jun 10;280(23):22540-8
references.pmid: 15824111
references.citation: J Neurosci. 2008 Oct 1;28(40):9929-38
references.pmid: 18829951
references.citation: Nature. 2010 Apr 15;464(7291):1006-11
references.pmid: 20228791
references.citation: Adv Exp Med Biol. 2011;704:209-19
references.pmid: 21290297
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17373-8
references.pmid: 18988737
references.citation: J Neurosci. 2004 Oct 13;24(41):9059-66
references.pmid: 15483124
references.citation: PLoS Genet. 2011 Apr;7(4):e1002041
references.pmid: 21490957
references.citation: Nat Commun. 2013;4:2399
references.pmid: 24008932
references.citation: J Clin Invest. 2009 Sep;119(9):2737-44
references.pmid: 19726882
references.citation: Genome Biol. 2011;12(3):218
references.pmid: 21401968
references.citation: Nature. 2007 Feb 1;445(7127):541-5
references.pmid: 17237762
references.citation: Cell. 2003 Apr 18;113(2):261-73
references.pmid: 12705873
references.citation: J Biol Chem. 2012 Jan 20;287(4):2388-97
references.pmid: 22130664
references.citation: Pflugers Arch. 2012 Nov;464(5):425-58
references.pmid: 23001121
references.citation: Arch Pharm Res. 2012 Oct;35(10):1823-30
references.pmid: 23139135
references.citation: Nat Neurosci. 2008 Jun;11(6):676-82
references.pmid: 18469811