title: Urinary triclosan concentrations are inversely associated with body mass index and waist circumference in the US general population: Experience in NHANES 2003-2010.
abstract: BACKGROUND
  Humans are extensively exposed to triclosan, an antibacterial and antifungal agent. Triclosan's effects on human health, however, have not been carefully investigated.
  
  
  OBJECTIVE
  To examine whether triclosan exposure is associated with obesity traits.
  
  
  METHODS
  This study included 2898 children (6-19 years old) and 5066 adults (20 years or older) who participated in the National Health and Nutrition Examination Surveys (NHANES) 2003-2010 and had a detectable level of urinary triclosan. Multiple linear regression models were used to examine the association between urinary triclosan and both body mass index (BMI) and waist circumference.
  
  
  RESULTS
  Each standard deviation increase in urinary triclosan was associated with a 0.34 (95% confidence interval, CI: 0.05, 0.64) kg/m² lower level of BMI (P=0.02) and 0.92 (95% CI: 0.09, 1.74)cm smaller waist circumference (P=0.03) in boys, and a 0.62 (95% CI: 0.31, 0.94) kg/m² lower level of BMI (P=0.0002) and 1.32 (95% CI: 0.54, 2.09) cm smaller waist circumference in girls (P=0.001); a 0.42 (95% CI: 0.06, 0.77) kg/m² lower level of BMI (P=0.02) and 1.35 (95% CI: 0.48, 2.22) cm smaller waist circumference (P=0.003) in men, and a 0.71 (95% CI: 0.34, 1.07) kg/m² lower level of BMI (P=0.0002) and 1.68 (95% CI: 0.86, 2.50) cm smaller waist circumference (P=0.0001) in women. In both children and adults, there was a consistent trend for lower levels of BMI and smaller waist circumference with increasing levels of urinary triclosan, from the lowest to the highest quartile of urinary triclosan (P ≤ 0.001 in all cases).
  
  
  CONCLUSIONS
  Triclosan exposure is inversely associated with BMI and waist circumference. The biological mechanisms linking triclosan exposure to obesity await further investigation.
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States. Electronic address: sli10@tulane.edu.
authors.forename: Shengxu
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, United States.
authors.forename: Guangdi
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
authors.forename: Felicia
authors.initials: F
authors.lastname: Rabito
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, United States; Ochsner Health System, New Orleans, LA 70121, United States.
authors.forename: Marie
authors.initials: M
authors.lastname: Krousel-Wood
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, United States.
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000652:urine*; D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys / Q000706:statistics & numerical data*; D009765:Obesity / Q000652:urine; D014260:Triclosan / Q000652:urine*; D014481:United States; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D014260:Triclosan
keywords: NHANES; Obesity; Triclosan
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