title: Comparison the effects of paracetamol with sufentanil infusion on postoperative pain control after craniotomy in patients with brain tumor.
abstract: BACKGROUND
  Patients experience severe pain after craniotomy surgery that leads to discomfort. Our target in this study that performed in interventional method is an evaluation of sufentanil and paracetamol effect on postoperative pain control in patients undergone craniotomy surgery at Urmia Imam Khomeini Hospital.
  
  
  METHODS
  Totally, 45 patients between the ages 18 and 65 were studied. The effect of sufentanil and paracetamol medicines in pain management, hemodynamic stability, and side effects compared with control group that were receiving morphine (subcutaneous [SC]) in 3 groups of 15 people at time 0, 2, 4, 12 and 24-h were evaluated. Collected data were included and monitoring blood pressure, O2 Sat, heart rate (HR) and pain, nausea, vomiting and use of morphine.
  
  
  RESULTS
  According to the analysis of results, there was a significant difference between 3 groups on postoperative pain (P < 0.05). In patients that used sufentanil, pain score of visual analog scale (VAS) is lowest and in the paracetamol group the highest VAS score was seen. There was a significant difference in HR between 3 groups (P < 0.05). Maximum average of HR was observed in the paracetamol group. There was a significant difference in mean arterial pressure between 3 groups (P < 0.05). In paracetamol group, there was the highest value (99.3). There was no significant difference in Glasgow Coma scale and SPO2 between 3 groups (P > 0.05).
  
  
  CONCLUSIONS
  Sufentanil compared to morphine (which is routinely used for patients pain control after craniotomy surgery) has better pain control, less nausea and vomiting, and better hemodynamic stability. Although paracetamol has the least nausea and vomiting, it has the lowest quality of pain relief.
authors.affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Hassani
authors.affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Mahoori
authors.affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Shahryar
authors.initials: S
authors.lastname: Sane
authors.affiliation: Department of Anesthesiology, Urmia University of Medical Sciences, Urmia, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Tolumehr
keywords: Craniotomy; paracetamol; postoperative pain management; sufentanil; visual analogue scale
references.citation: Anesth Analg. 2012 Feb;114(2):416-23
references.pmid: 22156333
references.citation: Br J Neurosurg. 2011 Feb;25(1):100-3
references.pmid: 21158514
references.citation: Neurosurgery. 2006 Oct;59(4):852-7; discussion 857
references.pmid: 17038949
references.citation: J Neurosurg. 2009 Aug;111(2):343-50
references.pmid: 19249923
references.citation: Anesthesiol Clin. 2012 Jun;30(2):347-67
references.pmid: 22901614
references.citation: J Neurosurg Anesthesiol. 2002 Apr;14(2):96-101
references.pmid: 11907388