title: Transcranial cortical stimulation in the treatment of obsessive-compulsive disorders: efficacy studies.
abstract: Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation methods that became widely used as therapeutic tools during the past two decades especially in cases of depression and schizophrenia. Low frequency rTMS and cathodal effect of tDCS inhibits cortical functioning while high frequency and anodal effect of tDCS have the opposite effect. Prolonged and repetitive application of either methods leads to changes in excitability of the human cortex that outlast the period of stimulation. Both rTMS and tDCS induce functional changes in the brain-modulating neural activity at cortical level. This paper reviews rTMS and tDCS effects in clinical trials for obsessive-compulsive disorder (OCD). Low frequency rTMS, particularly targeting the supplementary motor area and the orbital frontal cortex, seems to be the most promising in terms of therapeutic efficacy while older studies targeting the prefrontal dorsal cortex were not as successful. tDCS clearly needs to be investigated in large scale and sufficiently powered randomized control studies. From a general point of view, these non-invasive techniques hold promise as novel therapeutic tools for OCD patients.
authors.affiliation: Service de Psychiatrie, AP-HP, Hôpitaux Universitaires Henri-Mondor, Créteil, 94000, France, saba.ghassen@wanadoo.fr.
authors.forename: Ghassen
authors.initials: G
authors.lastname: Saba
authors.forename: Albert
authors.initials: A
authors.lastname: Moukheiber
authors.forename: Antoine
authors.initials: A
authors.lastname: Pelissolo
mesh_terms: D002986:Clinical Trials as Topic; D004566:Electrodes; D005625:Frontal Lobe; D006801:Humans; D009044:Motor Cortex; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000628:therapy*; D017397:Prefrontal Cortex; D065908:Transcranial Direct Current Stimulation / Q000379:methods; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome
references.citation: Brain Stimul. 2009 Oct;2(4):241-5
references.pmid: 20633424
references.citation: J Psychiatr Res. 2013 Aug;47(8):999-1006
references.pmid: 23615189
references.citation: Bipolar Disord. 2006 Apr;8(2):203-4
references.pmid: 16542193
references.citation: Chin Med J (Engl). 2014;127(4):601-6
references.pmid: 24534207
references.citation: Indian J Psychiatry. 2011 Oct;53(4):340-2
references.pmid: 22303044
references.citation: Neurosci Biobehav Rev. 2008;32(3):525-49
references.pmid: 18061263
references.citation: Psychiatry Res. 2001 Jul 1;107(1):51-6
references.pmid: 11472864
references.citation: Arch Gen Psychiatry. 2005 Mar;62(3):301-9
references.pmid: 15753243
references.citation: Psychiatry Res. 2013 Dec 30;210(3):1026-32
references.pmid: 24064461
references.citation: Int J Neuropsychopharmacol. 2006 Feb;9(1):95-100
references.pmid: 15982444
references.citation: Trends Cogn Sci. 2012 Jan;16(1):43-51
references.pmid: 22138231
references.citation: Am J Psychiatry. 2001 Jul;158(7):1143-5
references.pmid: 11431238
references.citation: Neurosci Biobehav Rev. 2005 May;29(3):399-419
references.pmid: 15820546
references.citation: Neurology. 2001 Nov 27;57(10):1899-901
references.pmid: 11723286
references.citation: Brain Res Bull. 2006 Feb 15;68(6):459-63
references.pmid: 16459203
references.citation: Psychiatry Res. 2004 Nov 15;132(1):69-79
references.pmid: 15546704
references.citation: Int J Neuropsychopharmacol. 2008 Mar;11(2):249-54
references.pmid: 17559710
references.citation: Br J Psychiatry Suppl. 1998;(35):26-37
references.pmid: 9829024
references.citation: Pain. 2006 May;122(1-2):197-209
references.pmid: 16564618
references.citation: J Clin Psychiatry. 2007 Mar;68(3):416-21
references.pmid: 17388712
references.citation: Int J Neuropsychopharmacol. 2002 Mar;5(1):73-103
references.pmid: 12057034
references.citation: J Neurosci. 2004 Mar 31;24(13):3379-85
references.pmid: 15056717
references.citation: Biol Psychiatry. 2005 Jan 1;57(1):16-20
references.pmid: 15607295
references.citation: J Cogn Neurosci. 2008 May;20(5):751-61
references.pmid: 18201122
references.citation: Cereb Cortex. 2003 Sep;13(9):977-86
references.pmid: 12902397
references.citation: Neurocase. 2013 Aug;19(4):360-70
references.pmid: 22554168
references.citation: Brain. 2005 Mar;128(Pt 3):490-9
references.pmid: 15634731
references.citation: J Clin Psychiatry. 2001 Dec;62(12):981-4
references.pmid: 11780880
references.citation: Am J Psychiatry. 1988 Dec;145(12 ):1560-3
references.pmid: 3264118
references.citation: Biol Psychiatry. 2005 Jul 15;58(2):97-104
references.pmid: 15936729
references.citation: Neuroimage. 2001 Oct;14 (4):883-90
references.pmid: 11554807
references.citation: Arch Gen Psychiatry. 1992 Sep;49(9):690-4
references.pmid: 1514873
references.citation: Clin Neurophysiol. 2007 Oct;118(10):2314-5
references.pmid: 17709291
references.citation: J Clin Psychiatry. 2010 Jul;71(7):873-84
references.pmid: 20361902
references.citation: J Physiol. 2000 Sep 15;527 Pt 3:633-9
references.pmid: 10990547
references.citation: N Engl J Med. 2008 Nov 13;359(20):2121-34
references.pmid: 19005196
references.citation: Psychol Med. 2007 Nov;37(11):1645-9
references.pmid: 17655805
references.citation: Exp Neurol. 2009 Sep;219(1):14-9
references.pmid: 19348793
references.citation: J Clin Neurophysiol. 1998 Jul;15(4):333-43
references.pmid: 9736467
references.citation: Brain Stimul. 2008 Jul;1(3):206-23
references.pmid: 20633386
references.citation: J Anxiety Disord. 2010 Jun;24(5):535-9
references.pmid: 20392594
references.citation: J Affect Disord. 2009 Jun;115(3):386-94
references.pmid: 19027962
references.citation: J Clin Psychiatry. 2009 Dec;70(12):1645-51
references.pmid: 19709504
references.citation: Annu Rev Psychol. 2008;59:537-63
references.pmid: 17937603
references.citation: Am J Psychiatry. 2006 Jul;163(7):1282-4
references.pmid: 16816237
references.citation: Int J Neuropsychopharmacol. 2010 Mar;13(2):217-27
references.pmid: 19691873
references.citation: Neuro Endocrinol Lett. 2006 Jun;27(3):327-32
references.pmid: 16816829
references.citation: Am J Psychiatry. 2012 Jul;169(7):719-24
references.pmid: 22581236
references.citation: Int J Neuropsychopharmacol. 2011 Nov;14(10):1389-97
references.pmid: 21557884
references.citation: Prim Care Companion J Clin Psychiatry. 2009;11(5):226-30
references.pmid: 19956460
references.citation: Clin Neurophysiol. 2003 Apr;114(4):600-4
references.pmid: 12686268
references.citation: Am J Psychiatry. 1997 Jun;154(6):867-9
references.pmid: 9167520
references.citation: Cochrane Database Syst Rev. 2003;(3):CD003387
references.pmid: 12917964
references.citation: J Clin Psychiatry. 2010 Apr;71(4):504-6
references.pmid: 20409448
references.citation: Br J Pharmacol. 2011 Oct;164(4):1044-61
references.pmid: 21486280
references.citation: J Neuropsychiatry Clin Neurosci. 2012 Fall;24(4):437-43
references.pmid: 23224449
references.citation: Biol Psychiatry. 2004 Nov 1;56(9):634-9
references.pmid: 15522246
references.citation: Nature. 2000 Jul 13;406(6792):147-50
references.pmid: 10910346
references.citation: Hum Brain Mapp. 2012 Oct;33(10):2499-508
references.pmid: 21922602
references.citation: World J Biol Psychiatry. 2012 Mar;13(3):164-77
references.pmid: 21623668
references.citation: Curr Opin Psychiatry. 2013 Jan;26(1):13-8
references.pmid: 23154644
references.citation: Neuropsychobiology. 2011;64(2):61-85
references.pmid: 21701225
references.citation: J Physiol. 1964 Aug;172:369-82
references.pmid: 14199369
references.citation: Exp Brain Res. 2003 Mar;149(2):214-21
references.pmid: 12610690