title: HOMA, BMI, and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic, Nonobese, and Nondiabetic Chronic Hepatitis C Genotype 1 Patients.
abstract: Objective. To investigate the relationship between insulin resistance and viral load decay in nondiabetic and noncirrhotic genotype 1 chronic HCV patients during peginterferon and ribavirin treatment and the possible influence of BMI and leptin as metabolic confounders. Methods. 75 consecutive noncirrhotic, nonobese, and nondiabetic patients with genotype 1 chronic hepatitis C treated with peginterferon alpha 2a plus ribavirin were evaluated. HOMA-IR, serum leptin, and BMI were measured in all patients at baseline and at weeks 12 and 48, whereas viral load was measured at the same time points and then 24 weeks after the end of treatment. Results. HOMA-IR was significantly associated with both BMI and leptin at baseline. During peginterferon plus ribavirin treatment, there was a significant reduction of HOMA-IR at weeks 12 and 48 from baseline (P = 0.033 and 0.048, resp.) in patients who achieved an early viral load decay (EVR), a trend not observed in patients who not achieved EVR. No variations during treatment were observed regarding BMI and leptin irrespective of EVR. Conclusion. The early reduction of HOMA-IR but not of BMI and leptin during antiviral treatment in noncirrhotic, chronic hepatitis C genotype 1 patients who achieved EVR suggests a viral genesis of insulin resistance in patients with nonmetabolic phenotype.
authors.affiliation: Gastroenterology Unit, San Paolo Hospital, Via Genova 38, 17100 Savona, Italy.
authors.forename: Alessandro
authors.identifier: 0000-0003-2401-3861
authors.initials: A
authors.lastname: Grasso
authors.affiliation: Gastroenterology Unit, San Paolo Hospital, Via Genova 38, 17100 Savona, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Malfatti
authors.affiliation: Department of Endocrinology, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Andraghetti
authors.affiliation: Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Marenco
authors.affiliation: Department of Endocrinology, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Mazzucchelli
authors.affiliation: Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Labanca
authors.affiliation: Department of Endocrinology, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Cordera
authors.affiliation: Gastroenterology Unit, San Paolo Hospital, Via Genova 38, 17100 Savona, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Testa
authors.affiliation: Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, 16132 Genoa, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Picciotto
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