title: Regional brain monitoring in the neurocritical care unit.
abstract: Regional multimodality monitoring has evolved over the last several years as a tool to understand the mechanisms of brain injury and brain function at the cellular level. Multimodality monitoring offers an important augmentation to the clinical exam and is especially useful in comatose neurocritical care patients. Cerebral microdialysis, brain tissue oxygen monitoring, and cerebral blood flow monitoring all offer insight into permutations in brain chemistry and function that occur in the context of brain injury. These tools may allow for development of individual therapeutic strategies that are mechanistically driven and goal-directed. We present a summary of the discussions that took place during the Second Neurocritical Care Research Conference regarding regional brain monitoring.
authors.affiliation: Cerebrovascular Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland Clinic Mail Code S80, Cleveland, OH, 44195, USA, jisuarez@bcm.tmc.edu.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Frontera
authors.forename: Wendy
authors.initials: W
authors.lastname: Ziai
authors.forename: Kristine
authors.initials: K
authors.lastname: O'Phelan
authors.forename: Peter D
authors.initials: PD
authors.lastname: Leroux
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Kirkpatrick
authors.forename: Michael N
authors.initials: MN
authors.lastname: Diringer
authors.forename: Jose I
authors.initials: JI
authors.lastname: Suarez
mesh_terms: D001927:Brain Diseases / Q000378:metabolism* / Q000503:physiopathology* / Q000628:therapy; D003422:Critical Care; D006801:Humans; D064926:Neurophysiological Monitoring
references.citation: Acta Physiol Scand. 1986 Aug;127(4):547-51
references.pmid: 3092579
references.citation: Brain Res. 1991 Dec 13;567(1):1-10
references.pmid: 1667742
references.citation: Neurosci Lett. 1985 Dec 4;62(2):231-5
references.pmid: 4088534
references.citation: J Neurosurg. 2005 Jul;103(1):25-30
references.pmid: 16121969
references.citation: J Neurosurg. 2000 Jan;92 (1):7-13
references.pmid: 10616076
references.citation: J Cereb Blood Flow Metab. 2005 Jun;25(6):763-74
references.pmid: 15716852
references.citation: Crit Care Med. 2009 Jan;37(1):283-90
references.pmid: 19050612
references.citation: J Neurosurg. 2012 Mar;116(3):648-56
references.pmid: 22098203
references.citation: Crit Care Med. 2009 Jun;37(6):2057-63
references.pmid: 19384213
references.citation: Anesth Analg. 2008 Jan;106(1):234-9, table of contents
references.pmid: 18165583
references.citation: Neurosurgery. 2011 Nov;69(5):1037-45; discussion 1045
references.pmid: 21673608
references.citation: Neurocrit Care. 2011 Jun;14(3):361-9
references.pmid: 21394543
references.citation: Acta Neurochir Suppl. 2008;102:145-51
references.pmid: 19388307
references.citation: Neurol Res. 1998;20 Suppl 1:S91-4
references.pmid: 9584933
references.citation: Acta Physiol Scand. 1986 Sep;128(1):9-14
references.pmid: 2876587
references.citation: Stroke. 2012 Dec;43(12 ):3230-7
references.pmid: 23150652
references.citation: Crit Care Med. 2009 Feb;37(2):432-40
references.pmid: 19114880
references.citation: Life Sci. 1990;46(4):301-8
references.pmid: 2304373
references.citation: J Head Trauma Rehabil. 2001 Apr;16(2):135-48
references.pmid: 11275575
references.citation: Stroke. 2006 Nov;37(11):2720-5
references.pmid: 17008623
references.citation: Acta Neurochir Suppl. 2005;95:25-8
references.pmid: 16463814
references.citation: J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):455-61
references.pmid: 11561027
references.citation: Neurocrit Care. 2012 Oct;17 (2):211-8
references.pmid: 21691895
references.citation: N Engl J Med. 2012 Dec 27;367 (26):2471-81
references.pmid: 23234472
references.citation: J Neurosurg Anesthesiol. 2011 Jan;23 (1):41-4
references.pmid: 21252706
references.citation: J Cereb Blood Flow Metab. 1996 Jul;16(4):637-44
references.pmid: 8964803
references.citation: J Neurosurg. 2008 Jan;108(1):66-73
references.pmid: 18173312
references.citation: J Cereb Blood Flow Metab. 1992 Jan;12(1):12-24
references.pmid: 1345756
references.citation: Neurosurgery. 1997 Jul;41(1):11-7; discussion 17-9
references.pmid: 9218290
references.citation: Stroke. 2009 Sep;40(9):3039-44
references.pmid: 19628806
references.citation: Neurocrit Care. 2012 Aug;17(1):131-8
references.pmid: 21845489
references.citation: J Neurosurg. 2003 Dec;99(6):991-8
references.pmid: 14705726
references.citation: Stroke. 1996 Oct;27(10 ):1829-34
references.pmid: 8841340
references.citation: Neurosurgery. 2000 Sep;47(3):701-9; discussion 709-10
references.pmid: 10981758
references.citation: Acta Neurochir (Wien). 1990;102(3-4):91-7
references.pmid: 1970920
references.citation: J Neurotrauma. 1988;5(4):315-30
references.pmid: 3249310
references.citation: Neurosurgery. 2013 May;72(5):840-4
references.pmid: 23392270
references.citation: Stroke. 2003 Oct;34(10 ):2404-9
references.pmid: 12947157