title: Xueshuan Xinmaining Tablet Treats Blood Stasis through Regulating the Expression of F13a1, Car1, and Tbxa2r.
abstract: Xueshuan Xinmaining Tablet (XXT), the Chinese formula, has long been administered in clinical practice for the treatment of cerebral thrombosis and coronary heart disease. In this study, we aimed to study the effect and the molecular mechanism of activating blood circulation and removing blood stasis. Rat models of cold coagulation blood stasis were induced with ice-water bath and epinephrine to assess the amelioration of blood stasis by XXT. Microarray technique was used to identify gene expression from the model and XXT-treated rats. In addition, Quantitative Real-Time PCR (qPCR) was performed to verify the microarray results. The results showed that XXT had a good therapeutic effect on blood stasis by reducing the whole blood viscosity (WBV), plasma viscosity (PV), increasing PT, APTT and TT, and by inhibiting platelet aggregation. Genes were differentially expressed in rats among the model group and the XXT-pretreated groups. XXT ameliorated blood stasis by regulating the expressions of F13a1, Car1, and Tbxa2r.
authors.affiliation: Department of Pathogeny Biology, Basic Medical College, Jilin University, Changchun 130021, China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Pathogeny Biology, Basic Medical College, Jilin University, Changchun 130021, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Pathogeny Biology, Basic Medical College, Jilin University, Changchun 130021, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Sai
authors.affiliation: Department of Pathogeny Biology, Basic Medical College, Jilin University, Changchun 130021, China.
authors.forename: Fan
authors.identifier: 0000-0002-7998-0093
authors.initials: F
authors.lastname: Li
authors.affiliation: Departments of Pharmaceutical, Jilin University, Changchun 130021, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Hospital, Jilin University, Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathogeny Biology, Basic Medical College, Jilin University, Changchun 130021, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
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