title: [Microviscosity of erythrocyte membranes in chronic coronary insufficiency in patients of middle and older age groups].
abstract: We examined the ratios microviscosity in the area of integral and annularly lipid membranes of erythrocytes of peripheral blood in patients of 35-50 and 60-75 years with chronic ischemic heart disease, as well as age-matched healthy controls. In healthy donors coefficients microviscosity in the area of integral and annularly lipids proved to be significantly higher in the older age group (60-75 years). In CHD, regardless of the age of the patients, erythrocyte membranes can be characterized as raising and lowering the parameters microviscosity of lipid-lipid interactions. In the protein-lipid contacts for patients aged 35-50 years an increase is typical, while for patients of 60-75 years, on the contrary, a decrease of the coefficient of microviscosity. It is concluded that the values of the microviscosity of erythrocyte membranes in patients of different age groups in the development of chronic ischemic heart disease, reflect both the implementation of the general mechanisms of adaptive changes of cell membranes, and the specifics of an individual, determined by their lipid and protein composition.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Rebrova
authors.forename: S A
authors.initials: SA
authors.lastname: Afanas'ev
authors.forename: O D
authors.initials: OD
authors.lastname: Putrova
authors.forename: A N
authors.initials: AN
authors.lastname: Repin
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D001809:Blood Viscosity; D016022:Case-Control Studies; D055598:Chemical Phenomena; D002908:Chronic Disease; D004910:Erythrocyte Membrane / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D018056:Hemorheology; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications
chemical_list: D008563:Membrane Lipids