title: Weaker Seniors Exhibit Motor Cortex Hypoexcitability and Impairments in Voluntary Activation.
abstract: BACKGROUND
  Weakness predisposes seniors to a fourfold increase in functional limitations. The potential for age-related degradation in nervous system function to contribute to weakness and physical disability has garnered much interest of late. In this study, we tested the hypothesis that weaker seniors have impairments in voluntary (neural) activation and increased indices of GABAergic inhibition of the motor cortex, assessed using transcranial magnetic stimulation.
  
  
  METHODS
  Young adults (N = 46; 21.2±0.5 years) and seniors (N = 42; 70.7±0.9 years) had their wrist flexion strength quantified along with voluntary activation capacity (by comparing voluntary and electrically evoked forces). Single-pulse transcranial magnetic stimulation was used to measure motor-evoked potential amplitude and silent period duration during isometric contractions at 15% and 30% of maximum strength. Paired-pulse transcranial magnetic stimulation was used to measure intracortical facilitation and short-interval and long-interval intracortical inhibition. The primary analysis compared seniors to young adults. The secondary analysis compared stronger seniors (top two tertiles) to weaker seniors (bottom tertile) based on strength relative to body weight.
  
  
  RESULTS
  The most novel findings were that weaker seniors exhibited: (i) a 20% deficit in voluntary activation; (ii) ~20% smaller motor-evoked potentials during the 30% contraction task; and (iii) nearly twofold higher levels of long-interval intracortical inhibition under resting conditions.
  
  
  CONCLUSIONS
  These findings indicate that weaker seniors exhibit significant impairments in voluntary activation, and that this impairment may be mechanistically associated with increased GABAergic inhibition of the motor cortex.
authors.affiliation: clarkb2@ohio.edu.
authors.forename: Brian C
authors.initials: BC
authors.lastname: Clark
authors.affiliation: Neuroscience Research Australia and the University of New South Wales, Randwick, Australia.
authors.forename: Janet L
authors.initials: JL
authors.lastname: Taylor
authors.forename: S Lee
authors.initials: SL
authors.lastname: Hong
authors.affiliation: Ohio Musculoskeletal and Neurological Institute (OMNI) at Ohio University, Athens. Department of Family Medicine at Ohio University, Athens.
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Law
authors.affiliation: Ohio Musculoskeletal and Neurological Institute (OMNI) at Ohio University, Athens. School of Rehabilitation and Communication Sciences at Ohio University, Athens.
authors.forename: David W
authors.initials: DW
authors.lastname: Russ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009119:Muscle Contraction / Q000502:physiology; D053580:Muscle Strength / Q000502:physiology; D018908:Muscle Weakness / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation; D055815:Young Adult
keywords: Dynapenia; Muscle; Sarcopenia; Transcranial magnetic stimulation.; Weakness
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