title: Latent sensitization: a model for stress-sensitive chronic pain.
abstract: Latent sensitization is a rodent model of chronic pain that reproduces both its episodic nature and its sensitivity to stress. It is triggered by a wide variety of injuries ranging from injection of inflammatory agents to nerve damage. It follows a characteristic time course in which a hyperalgesic phase is followed by a phase of remission. The hyperalgesic phase lasts between a few days to several months, depending on the triggering injury. Injection of μ-opioid receptor inverse agonists (e.g., naloxone or naltrexone) during the remission phase induces reinstatement of hyperalgesia. This indicates that the remission phase does not represent a return to the normal state, but rather an altered state in which hyperalgesia is masked by constitutive activity of opioid receptors. Importantly, stress also triggers reinstatement. Here we describe in detail procedures for inducing and following latent sensitization in its different phases in rats and mice.
authors.affiliation: Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.|Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Marvizon
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Wendy
authors.initials: W
authors.lastname: Walwyn
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
authors.forename: Ani
authors.initials: A
authors.lastname: Minasyan
authors.affiliation: Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.|Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
authors.forename: Wenling
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Physiology, School of Medicine, University of Kentucky Medical Center, Lexington, Kentucky.
authors.forename: Bradley K
authors.initials: BK
authors.lastname: Taylor
mesh_terms: D000818:Animals; D059333:Central Nervous System Sensitization / Q000502:physiology*; D059350:Chronic Pain / Q000503:physiopathology*; D002985:Clinical Protocols; D004195:Disease Models, Animal; D005260:Female; D006930:Hyperalgesia / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: chronic pain; constitutive activity; hyperalgesia; latent sensitization; neuropathic pain; opioid receptor; stress
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