title: [Systemic toxicity of local anaesthetics in children].
abstract: The article deals with an analysis of the publications devoted of local anaesthetics' systemic toxicity (LAST) due to regional anaesthesia and symptoms of this potentially lethal complication. The review discusses features of systemic absorption and forms of local anaesthetics' neurotoxicity and cardiotoxicity in children, including newborns, differences of clinical signs of the LAST in adults and children and dosage of racemic bupivacaine. Moreover, the article deals with a modified treatment protocol for LAST and a method of lipid resuscitation with 20% lipid emulsion in the form of Intralipid. In conclusion the article discusses recommendations for LAST prophylaxis and scenarios during cardiopulmonary and cerebral resuscitation.
authors.forename: O S
authors.initials: OS
authors.lastname: Geodakian
mesh_terms: D000765:Anesthesia, Conduction / Q000009:adverse effects* / Q000379:methods; D000779:Anesthetics, Local / Q000633:toxicity*; D066126:Cardiotoxicity; D002648:Child; D002675:Child, Preschool; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009420:Nervous System / Q000187:drug effects*
chemical_list: D000779:Anesthetics, Local