title: Etoposide incorporated into camel milk phospholipids liposomes shows increased activity against fibrosarcoma in a mouse model.
abstract: Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarcoma in a murine model. Fibrosarcoma was induced in mice by injecting benzopyrene (BAP) and tumor-bearing mice were treated with various formulations of etoposide, including etoposide entrapped camel milk phospholipids liposomes (ETP-Cam-liposomes) and etoposide-loaded DPPC-liposomes (ETP-DPPC-liposomes). The tumor-bearing mice treated with ETP-Cam-liposomes showed slow progression of tumors and increased survival compared to free ETP or ETP-DPPC-liposomes. These results suggest that ETP-Cam-liposomes may prove to be a better drug delivery system for anticancer drugs.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah 51412, Saudi Arabia.
authors.forename: Hamzah M
authors.initials: HM
authors.lastname: Maswadeh
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Qassim University, Buraidah 51412, Saudi Arabia.
authors.forename: Ahmad N
authors.initials: AN
authors.lastname: Aljarbou
authors.affiliation: Department of Pharmacology & Therapeutics, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
authors.forename: Mohammed S
authors.initials: MS
authors.lastname: Alorainy
authors.affiliation: Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia.
authors.forename: Mansour S
authors.initials: MS
authors.lastname: Alsharidah
authors.affiliation: Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia.
authors.forename: Masood A
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D002162:Camelus; D004058:Diffusion; D004357:Drug Synergism; D005047:Etoposide / Q000008:administration & dosage* / Q000737:chemistry; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000473:pathology*; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008081:Liposomes; D010743:Phospholipids; D005047:Etoposide
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