title: Rate of evolutionary change in cranial morphology of the marsupial genus Monodelphis is constrained by the availability of additive genetic variation.
abstract: We tested the hypothesis that the rate of marsupial cranial evolution is dependent on the distribution of genetic variation in multivariate space. To do so, we carried out a genetic analysis of cranial morphological variation in laboratory strains of Monodelphis domestica and used estimates of genetic covariation to analyse the morphological diversification of the Monodelphis brevicaudata species group. We found that within-species genetic variation is concentrated in only a few axes of the morphospace and that this strong genetic covariation influenced the rate of morphological diversification of the brevicaudata group, with between-species divergence occurring fastest when occurring along the genetic line of least resistance. Accounting for the geometric distribution of genetic variation also increased our ability to detect the selective regimen underlying species diversification, with several instances of selection only being detected when genetic covariances were taken into account. Therefore, this work directly links patterns of genetic covariation among traits to macroevolutionary patterns of morphological divergence. Our findings also suggest that the limited distribution of Monodelphis species in morphospace is the result of a complex interplay between the limited dimensionality of available genetic variation and strong stabilizing selection along two major axes of genetic variation.
authors.affiliation: Department of Biology, Washington University in St Louis, St Louis, MO, USA.
authors.forename: A
authors.initials: A
authors.lastname: Porto
authors.forename: H
authors.initials: H
authors.lastname: Sebastião
authors.forename: S E
authors.initials: SE
authors.lastname: Pavan
authors.forename: J L
authors.initials: JL
authors.lastname: VandeBerg
authors.forename: G
authors.initials: G
authors.lastname: Marroig
authors.forename: J M
authors.initials: JM
authors.lastname: Cheverud
mesh_terms: D000818:Animals; D005075:Biological Evolution; D014644:Genetic Variation; D048309:Monodelphis / Q000033:anatomy & histology* / Q000235:genetics*; D012886:Skull / Q000033:anatomy & histology
keywords: constraints; mammals; morphospace; quantitative genetics
references.citation: Evolution. 2001 Dec;55(12):2576-600
references.pmid: 11831671
references.citation: Genetica. 2001;112-113:9-32
references.pmid: 11838790
references.citation: Am J Phys Anthropol. 2002 Mar;117(3):260-71
references.pmid: 11842405
references.citation: Am Nat. 2004 Mar;163(3):417-28
references.pmid: 15026977
references.citation: Evolution. 2004 Oct;58(10):2353-70
references.pmid: 15562696
references.citation: Genetics. 2004 Dec;168(4):2295-306
references.pmid: 15611193
references.citation: Evolution. 2005 May;59(5):1128-42
references.pmid: 16136810
references.citation: J Evol Biol. 2007 Jan;20(1):1-8
references.pmid: 17209986
references.citation: Evol Dev. 2007 May-Jun;9(3):290-8
references.pmid: 17501752
references.citation: Bioessays. 2007 Dec;29(12):1185-8
references.pmid: 18008372
references.citation: Am Nat. 2008 Mar;171(3):366-85
references.pmid: 18194086
references.citation: PLoS Genet. 2008 Feb 29;4(2):e1000008
references.pmid: 18454194
references.citation: Genetics. 2008 Jun;179(2):977-84
references.pmid: 18505862
references.citation: J Evol Biol. 2008 Sep;21(5):1201-19
references.pmid: 18662244
references.citation: Proc Biol Sci. 2009 Mar 22;276(1659):1183-91
references.pmid: 19129097
references.citation: Evolution. 2010 May;64(5):1470-88
references.pmid: 20015239
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3400-5
references.pmid: 20133636
references.citation: J Exp Zool B Mol Dev Evol. 2010 Dec 15;314(8):663-83
references.pmid: 20718017
references.citation: Biol Lett. 2012 Feb 23;8(1):74-7
references.pmid: 21752813
references.citation: Evolution. 2012 May;66(5):1506-24
references.pmid: 22519787
references.citation: BMC Biol. 2013 Apr 26;11:52
references.pmid: 23622087
references.citation: Genetics. 2013 Jul;194(3):753-67
references.pmid: 23636737
references.citation: Evolution. 2013 Nov;67(11):3305-22
references.pmid: 24152009
references.citation: Nat Commun. 2014 Apr 04;5:3625
references.pmid: 24704703
references.citation: Philos Trans R Soc Lond B Biol Sci. 2014 Aug 19;369(1649):20130252
references.pmid: 25002697
references.citation: Mol Phylogenet Evol. 2014 Oct;79:199-214
references.pmid: 25017146
references.citation: Evolution. 1976 Jun;30(2):314-334
references.pmid: 28563044
references.citation: Evolution. 1975 Dec;29(4):707-722
references.pmid: 28563091
references.citation: Evolution. 1996 Oct;50(5):1766-1774
references.pmid: 28565589
references.citation: Evolution. 1988 Sep;42(5):1085-1089
references.pmid: 28581161