title: Memory, scene construction, and the human hippocampus.
abstract: We evaluated two different perspectives about the function of the human hippocampus--one that emphasizes the importance of memory and another that emphasizes the importance of spatial processing and scene construction. We gave tests of boundary extension, scene construction, and memory to patients with lesions limited to the hippocampus or large lesions of the medial temporal lobe. The patients were intact on all of the spatial tasks and impaired on all of the memory tasks. We discuss earlier studies that associated performance on these spatial tasks to hippocampal function. Our results demonstrate the importance of medial temporal lobe structures for memory and raise doubts about the idea that these structures have a prominent role in spatial cognition.
authors.affiliation: Veterans Affairs San Diego Healthcare System, San Diego, CA 92161; Departments of Psychiatry.
authors.forename: Soyun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Veterans Affairs San Diego Healthcare System, San Diego, CA 92161; Psychology, and.
authors.forename: Adam J O
authors.initials: AJ
authors.lastname: Dede
authors.affiliation: Department of Psychology and Neuroscience Center, Brigham Young University, Provo, UT 84143; and Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT 84143.
authors.forename: Ramona O
authors.initials: RO
authors.lastname: Hopkins
authors.affiliation: Veterans Affairs San Diego Healthcare System, San Diego, CA 92161; Departments of Psychiatry, Psychology, and Neurosciences, University of California at San Diego, La Jolla, CA 92093; lsquire@ucsd.edu.
authors.forename: Larry R
authors.initials: LR
authors.lastname: Squire
mesh_terms: D000328:Adult; D000368:Aged; D000647:Amnesia / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D065855:Spatial Processing / Q000502:physiology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*
keywords: amnesia; boundary extension; hippocampus; memory; spatial cognition
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