title: [Age-dependent CYP1A2 gene polymorphism -163C>A in three ethnic groups of Bashkortostan Republic residents].
abstract: On a sample of 1240 persons from Bashkortostan, including Russian, Bashkirs and Tatars, the analysis of allele and genotype frequencies distribution of CYP1A2 gene polymorphism -163C>A was performed by PCR-RFLP in view of belonging to a particular age cohort. In Russian and Bashkirs ethnic groups we observed age-dependent decrease of CYP1A2*C allele and CYP1A2*CI*C genotype frequencies (in Russian statistically significant for allele and genotype, the Bashkirs--only for allele) and a statistically significant increase of CYP1A2*A allele and CYP1A2*A/*A genotype frequencies. The set reduction in the frequency of the wild allele CYP1A2*C and increasing the frequency of the mutant allele CYP1A2*A with age may be due to greater survival of persons who are carriers of that allelic variants of CYP1A2 gene, providing a more efficient metabolism of xenobiotics.
authors.forename: V V
authors.initials: VV
authors.lastname: Érdman
authors.forename: T R
authors.initials: TR
authors.lastname: Nasibullin
authors.forename: I A
authors.initials: IA
authors.lastname: Tuktarova
authors.forename: G F
authors.initials: GF
authors.lastname: Korytina
authors.forename: L Z
authors.initials: LZ
authors.lastname: Akhmadishina
authors.forename: O V
authors.initials: OV
authors.lastname: Kochetova
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000208:ethnology* / Q000235:genetics*; D001486:Bashkiria / Q000208:ethnology; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics* / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics; D015262:Xenobiotics / Q000378:metabolism; D055815:Young Adult
chemical_list: D015262:Xenobiotics; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2