title: Photodynamic therapy as a new treatment modality for inflammatory and infectious conditions.
abstract: Photodynamic therapy (PDT) is currently used as a minimally invasive therapeutic modality for cancer. Whereas antitumor treatment regimens require lethal doses of photosensitizer and light, sublethal doses may have immunomodulatory effects, antibacterial action and/or regenerative properties. A growing body of evidence now indicates that non-lethal PDT doses can alleviate inflammation or treat established soft-tissue infections in various murine models of arthritis, experimental encephalomyelitis, inflammatory bowel disease and chronic skin ulcers. Furthermore, PDT is already used in clinical application and clinical trial for the treatment of psoriasis, chronic wounds and periodontitis in humans. Sublethal PDT should be regarded as a new viable option for the treatment of inflammatory conditions.
authors.affiliation: Université de Lorraine, Centre de recherche en automatique de Nancy, 54506 Vandoeuvre-lès-Nancy, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Reinhard
authors.forename: William J
authors.initials: WJ
authors.lastname: Sandborn
authors.forename: Hassan
authors.initials: H
authors.lastname: Melhem
authors.forename: Lina
authors.initials: L
authors.lastname: Bolotine
authors.forename: Mathias
authors.initials: M
authors.lastname: Chamaillard
authors.forename: Laurent
authors.initials: L
authors.lastname: Peyrin-Biroulet
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D006801:Humans; D007239:Infections / Q000628:therapy*; D007249:Inflammation / Q000628:therapy*; D051379:Mice; D010518:Periodontitis / Q000628:therapy*; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends; D011565:Psoriasis / Q000628:therapy*; D014945:Wound Healing
keywords: antimicrobial; immune modulation; inflammation; wound healing; • photodynamic therapy