title: An extraordinary relationship involving MIF-1 and other peptides.
abstract: In commemoration of Abba J. Kastin's exceptional service as the founding editor for the international journal Peptides, I review our collaborative work on how neuropeptides are involved in depression and other neuropsychiatric behavior. A special focus is on MIF-1 (prolyl-leucyl-glycinamide) that was discovered in the Kastin laboratory and shown effective to treat human depression with greater efficacy and faster onset of action than traditional antidepressants at the time of clinical trial. My personal reflection of the evolving changes of translational research on neuropeptides will hopefully provide some insight to young investigators.
authors.affiliation: Department of Psychiatry, Ochsner Medical Center, New Orleans, LA, USA. Electronic address: rudyehren@aol.com.
authors.forename: Rudolph H
authors.initials: RH
authors.lastname: Ehrensing
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D009075:MSH Release-Inhibiting Hormone / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D009075:MSH Release-Inhibiting Hormone
keywords: AJ Kastin; Depression; MIF-1; MSH/ACTH4-10; Peptides; TRH