title: Synthesis, characterization and anticancer activity of gold(I) complexes that contain tri-tert-butylphosphine and dialkyl dithiocarbamate ligands.
abstract: Two new gold(I) complexes that contain tri-ter-butylphosphine and dialkyl dithiocarbamate ligands were synthesized and characterized by FTIR, NMR spectroscopy, Cyclic voltammetry, elemental analysis and X-ray diffraction. The in vitro cytotoxicity of both complexes was examined against A549 (lung cancer), MCF7 (breast cancer), and HeLa (cervical cancer) human cancer cell lines. Both complexes exhibit very strong in vitro cytotoxic effects against A549, MCF7 and HeLa cell lines. The screening of the cytotoxic activity based on IC50 data against the A549, MCF7, and HeLa lines shows that the synthesized gold(I) complexes are highly effective, particularly against HeLa cancer cell line. Based on IC50 data, the cytotoxic activity of both complexes is better than well-known commercial anticancer drug cisplatin against all the three cancer lines tested.
authors.affiliation: Center of Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Altaf
authors.affiliation: Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Monim-ul-Mehboob
authors.affiliation: Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: Adam A A
authors.initials: AA
authors.lastname: Seliman
authors.affiliation: Center of Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: Manzar
authors.initials: M
authors.lastname: Sohail
authors.affiliation: Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia.
authors.forename: Mohammed I M
authors.initials: MI
authors.lastname: Wazeer
authors.affiliation: Department of Chemistry, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. Electronic address: aisab@kfupm.edu.sa.
authors.forename: Anvarhusein A
authors.initials: AA
authors.lastname: Isab
authors.affiliation: King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900 Jeddah, Saudi Arabia.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.affiliation: Deptartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
authors.forename: V
authors.initials: V
authors.lastname: Dhuna
authors.affiliation: Deptartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
authors.forename: G
authors.initials: G
authors.lastname: Bhatia
authors.affiliation: Deptartment of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar 143005, Punjab, India.
authors.forename: K
authors.initials: K
authors.lastname: Dhuna
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D004563:Electrochemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010720:Phosphines / Q000737:chemistry*; D013859:Thiocarbamates / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D010720:Phosphines; D013859:Thiocarbamates; D006046:Gold; C044646:phosphine
keywords: Anticancer activity; Gold(I) complexes; Human A549; MCF7 and HeLa cell lines