title: Au-catalyzed ring-opening reactions of 2-(1-alkynyl-cyclopropyl)pyridines with nucleophiles.
abstract: A novel method for the C-C bond cleavage of cyclopropanes was developed by gold-catalyzed cycloisomerization of 2-(1-alkynyl-cyclopropyl)pyridine with nucleophiles, which provides efficient access to structurally diverse indolizines under mild conditions. A series of N-, C- and O-based nucleophiles were involved in this reaction to afford the corresponding indolizines in modest to excellent yields.
authors.affiliation: College of Chemical Engineering, Zhejiang University of Technology, Chaowang Road 18#, Hangzhou 310014, China. yxjia@zjut.edu.cn.
authors.forename: Ren-Rong
authors.initials: RR
authors.lastname: Liu
authors.forename: Shi-Chun
authors.initials: SC
authors.lastname: Ye
authors.forename: Chuan-Jun
authors.initials: CJ
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Xiang
authors.forename: Jianrong
authors.initials: J
authors.lastname: Gao
authors.forename: Yi-Xia
authors.initials: YX
authors.lastname: Jia