title: Scalable Architecture for Federated Translational Inquiries Network (SAFTINet) Technology Infrastructure for a Distributed Data Network.
abstract: BACKGROUND
  Distributed Data Networks (DDNs) offer infrastructure solutions for sharing electronic health data from across disparate data sources to support comparative effectiveness research. Data sharing mechanisms must address technical and governance concerns stemming from network security and data disclosure laws and best practices, such as HIPAA.
  
  
  METHODS
  The Scalable Architecture for Federated Translational Inquiries Network (SAFTINet) deploys TRIAD grid technology, a common data model, detailed technical documentation, and custom software for data harmonization to facilitate data sharing in collaboration with stakeholders in the care of safety net populations. Data sharing partners host TRIAD grid nodes containing harmonized clinical data within their internal or hosted network environments. Authorized users can use a central web-based query system to request analytic data sets.
  
  
  CONCLUSIONS
  SAFTINet DDN infrastructure achieved a number of data sharing objectives, including scalable and sustainable systems for ensuring harmonized data structures and terminologies and secure distributed queries. Initial implementation challenges were resolved through iterative discussions, development and implementation of technical documentation, governance, and technology solutions.
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Schilling
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Bethany M
authors.initials: BM
authors.lastname: Kwan
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Charles T
authors.initials: CT
authors.lastname: Drolshagen
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Hosokawa
authors.affiliation: American Academy of Family Physicians.
authors.forename: Elias
authors.initials: E
authors.lastname: Brandt
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Wilson D
authors.initials: WD
authors.lastname: Pace
authors.affiliation: Recombinant by Deloitte.
authors.forename: Christopher
authors.initials: C
authors.lastname: Uhrich
authors.affiliation: Recombinant by Deloitte.
authors.forename: Michael
authors.initials: M
authors.lastname: Kamerick
authors.affiliation: Recombinant by Deloitte.
authors.forename: Aidan
authors.initials: A
authors.lastname: Bunting
authors.affiliation: The Ohio State University.
authors.forename: Philip R O
authors.initials: PR
authors.lastname: Payne
authors.affiliation: The Ohio State University.
authors.forename: William E
authors.initials: WE
authors.lastname: Stephens
authors.affiliation: The Ohio State University.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: George
authors.affiliation: The Ohio State University.
authors.forename: Mark
authors.initials: M
authors.lastname: Vance
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Kelli
authors.initials: K
authors.lastname: Giacomini
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Jason
authors.initials: J
authors.lastname: Braddy
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Mika K
authors.initials: MK
authors.lastname: Green
authors.affiliation: University of Colorado Anschutz Medical Campus.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kahn
keywords: Comparative Effectiveness; Data Use and Quality; De-identification; Health Information Technology; Research Networks; SAFTINet
references.citation: Science. 2005 May 6;308(5723):814-7
references.pmid: 15879208
references.citation: Indian J Endocrinol Metab. 2012 Nov;16(6):871-2
references.pmid: 23226628
references.citation: Bioinformatics. 2006 Aug 1;22(15):1910-6
references.pmid: 16766552
references.citation: JAMA. 2003 Sep 24;290(12):1624-32
references.pmid: 14506122
references.citation: J Am Med Inform Assoc. 2008 Mar-Apr;15(2):138-49
references.pmid: 18096909
references.citation: Appl Clin Inform. 2011 Aug 17;2(3):331-44
references.pmid: 23616879
references.citation: Arch Intern Med. 2010 Mar 8;170(5):403-4
references.pmid: 20212173
references.citation: N Engl J Med. 2000 Jun 22;342(25):1878-86
references.pmid: 10861324
references.citation: Stud Health Technol Inform. 2012;175:9-18
references.pmid: 22941983
references.citation: US Statut Large. 1996 Aug 21;110:1936-2103
references.pmid: 16477734
references.citation: J Chem Inf Model. 2006 May-Jun;46(3):971-84
references.pmid: 16711715
references.citation: Physiother Theory Pract. 2010 Jul;26(5):308-17
references.pmid: 20557261
references.citation: Health Aff (Millwood). 2010 Nov;29(11):2082-90
references.pmid: 21041752
references.citation: Ann Intern Med. 2009 Sep 1;151(5):341-4
references.pmid: 19638403