title: Oxidative stress: dual pathway induction in cardiorenal syndrome type 1 pathogenesis.
abstract: Cardiorenal Syndrome Type 1 (Type 1) is a specific condition which is characterized by a rapid worsening of cardiac function leading to acute kidney injury (AKI). Even though its pathophysiology is complex and not still completely understood, oxidative stress seems to play a pivotal role. In this study, we examined the putative role of oxidative stress in the pathogenesis of CRS Type 1. Twenty-three patients with acute heart failure (AHF) were included in the study. Subsequently, 11 patients who developed AKI due to AHF were classified as CRS Type 1. Quantitative determinations for IL-6, myeloperoxidase (MPO), nitric oxide (NO), copper/zinc superoxide dismutase (Cu/ZnSOD), and endogenous peroxidase activity (EPA) were performed. CRS Type 1 patients displayed significant augmentation in circulating ROS and RNS, as well as expression of IL-6. Quantitative analysis of all oxidative stress markers showed significantly lower oxidative stress levels in controls and AHF compared to CRS Type 1 patients (P < 0.05). This pilot study demonstrates the significantly heightened presence of dual oxidative stress pathway induction in CRS Type 1 compared to AHF patients. Our findings indicate that oxidative stress is a potential therapeutic target, as it promotes inflammation by ROS/RNS-linked pathogenesis.
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy.
authors.forename: Grazia Maria
authors.initials: GM
authors.lastname: Virzì
authors.affiliation: International Renal Research Institute of Vicenza (IRRIV), Italy ; Department of Nephrology and Dialysis, San Giovanni Di Dio Hospital, 92100 Agrigento, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Clementi
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: de Cal
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy ; Department of Medicine DIMED, University of Padua Medical School, 35128 Padua, Italy ; Laboratory of Experimental Hepatology, Department of Medicine, University of Padua, 35128 Padua, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Brocca
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy.
authors.forename: Sonya
authors.initials: S
authors.lastname: Day
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy ; Department of Information Engineering, University of Padua, 35128 Padua, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Pastori
authors.affiliation: Internal Medicine, San Bortolo Hospital, 36100 Vicenza, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Bolin
authors.affiliation: Internal Medicine, San Bortolo Hospital, 36100 Vicenza, Italy ; Internal Medicine Unit, Sant'Antonio Hospital, 35127 Padua, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Vescovo
authors.affiliation: Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, 36100 Vicenza, Italy ; International Renal Research Institute of Vicenza (IRRIV), Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Ronco
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D059347:Cardio-Renal Syndrome / Q000150:complications / Q000473:pathology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000473:pathology; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D009195:Peroxidase / Q000032:analysis; D010544:Peroxidases / Q000378:metabolism; D010865:Pilot Projects; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D015850:Interleukin-6; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D010544:Peroxidases; D009195:Peroxidase; D013482:Superoxide Dismutase
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