title: Air pollution exposure: a novel environmental risk factor for interstitial lung disease?
abstract: Air pollution exposure is a well-established risk factor for several adverse respiratory outcomes, including airways diseases and lung cancer. Few studies have investigated the relationship between air pollution and interstitial lung disease (ILD) despite many forms of ILD arising from environmental exposures. There are potential mechanisms by which air pollution could cause, exacerbate, or accelerate the progression of certain forms of ILD via pulmonary and systemic inflammation as well as oxidative stress. This article will review the current epidemiologic and translational data supporting the plausibility of this relationship and propose a new conceptual framework for characterizing novel environmental risk factors for these forms of lung disease.
authors.affiliation: Department of Medicine, University of California, San Francisco, CA; Department of Medicine, University of Calgary, Calgary, AB, Canada.
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Johannson
authors.affiliation: Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA.
authors.forename: John R
authors.initials: JR
authors.lastname: Balmes
authors.affiliation: Department of Medicine, University of California, San Francisco, CA. Electronic address: kerri.johannson@albertahealthservices.ca.
authors.forename: Harold R
authors.initials: HR
authors.lastname: Collard
mesh_terms: D000397:Air Pollution / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D014943:Global Health; D006801:Humans; D015994:Incidence; D017563:Lung Diseases, Interstitial / Q000139:chemically induced / Q000453:epidemiology*; D012307:Risk Factors
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