title: Biophysical insights into the intercalative interaction of surfactant cobalt(III) complexes of certain diimine ligands bound to yeast tRNA: Effects of hydrophobicity.
abstract: The interaction of two surfactant cobalt(III) complexes, cis-[Co(ip)₂(DA)₂](ClO₄)₃ 1 and cis-[Co(dpq)₂(DA)₂](ClO₄)₃ 2 where ip=imidazo[4,5-f][1,10]phenanthroline and dpq=dipyrido[3,2-d:2'-3'-f]quinoxaline with yeast tRNA have been explored by using electronic absorption, competitive binding, electrochemical studies and viscosity measurements. The results suggest that these complexes can bind to tRNA by intercalation. The presence of hydrophobic diimine ligand and the long aliphatic double chains of these complexes facilitate its intercalative interaction with the hydrophobic interior of the tRNA. The extent of tRNA binding of complex 2 has greater affinity than that of complex containing imidazo[4,5-f][1,10]phenanthroline ligands.
authors.affiliation: School of Chemistry, Bharathidasan University, Trichirappalli 620024, Tamilnadu, India.
authors.forename: Karuppiah
authors.initials: K
authors.lastname: Nagaraj
authors.affiliation: School of Chemistry, Bharathidasan University, Trichirappalli 620024, Tamilnadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Sakthinathan
authors.affiliation: School of Chemistry, Bharathidasan University, Trichirappalli 620024, Tamilnadu, India. Electronic address: arunasurf@yahoo.com.
authors.forename: Sankaralingam
authors.initials: S
authors.lastname: Arunachalam
mesh_terms: D000818:Animals; D002417:Cattle; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D007097:Imines / Q000737:chemistry / Q000494:pharmacology; D007364:Intercalating Agents / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D010618:Phenanthrolines / Q000737:chemistry / Q000494:pharmacology; D012331:RNA, Fungal / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D056831:Coordination Complexes; D007097:Imines; D007364:Intercalating Agents; D008024:Ligands; D010618:Phenanthrolines; D012331:RNA, Fungal; D013501:Surface-Active Agents; D003035:Cobalt; D004247:DNA; D012343:RNA, Transfer; C427203:calf thymus DNA
keywords: Competitive binding; Hydrophobicity; Intercalation; Surfactant cobalt(IIII) complex; tRNA