title: Heroin use in Indonesia is associated with higher expression of CCR5 on CD4+ cells and lower ex-vivo production of CCR5 ligands.
abstract: Opioid use may affect HIV infection through altered expression of HIV co-receptors. This was examined in Indonesia among antiretroviral therapy-naive HIV patients, many of whom use drugs. C-C chemokine receptor type 5 (CCR5) expression on CD4+ cells was higher in heroin (P = 0.007), methadone (P = 0.024) and former opioid users (P = 0.003) compared to nonusers, whereas production of RANTES and other CCR5 ligands was similar or lower. This suggests that opioids can affect HIV susceptibility through up-regulation of CCR5 or down-regulation of its ligands.
authors.forename: Hinta
authors.initials: H
authors.lastname: Meijerink
authors.forename: Agnes R
authors.initials: AR
authors.lastname: Indrati
authors.forename: Suharyani
authors.initials: S
authors.lastname: Soedarmo
authors.forename: Fitri
authors.initials: F
authors.lastname: Utami
authors.forename: Cor A J
authors.initials: CA
authors.lastname: de Jong
authors.forename: Bachti
authors.initials: B
authors.lastname: Alisjahbana
authors.forename: Reinout
authors.initials: R
authors.lastname: van Crevel
authors.forename: Rudi
authors.initials: R
authors.lastname: Wisaksana
authors.forename: Andre J A M
authors.initials: AJ
authors.lastname: Van der Ven
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000187:drug effects*; D018946:Chemokine CCL5 / Q000032:analysis*; D005260:Female; D006556:Heroin Dependence / Q000276:immunology*; D006801:Humans; D007214:Indonesia; D008297:Male; D009293:Opioid-Related Disorders / Q000276:immunology*; D019713:Receptors, CCR5 / Q000032:analysis*; D015728:Receptors, HIV / Q000032:analysis*
chemical_list: C584933:CCR5 protein, human; D018946:Chemokine CCL5; D019713:Receptors, CCR5; D015728:Receptors, HIV