title: Invasive pulmonary aspergillosis due to Aspergillus lentulus: Successful treatment of a liver transplant patient.
abstract: We report a patient with severe invasive pulmonary fungal infection caused by Aspergilllus lentulus, which was identified by genetic analysis, following liver transplantation. The patient was initially suspected to have Aspergilllus fumigatus infection, but worsened clinically despite antifungal therapy appropriate for that species. The patient survived after accurate diagnosis, and detailed drug susceptibility testing led to adequate therapy, demonstrating the importance of performing these investigations for severely immunocompromised patients, including organ transplant recipients.
authors.affiliation: Division of Infection Control and Prevention, Osaka University Hospital, Suita City, Osaka, Japan.
authors.forename: Hisao
authors.initials: H
authors.lastname: Yoshida
authors.affiliation: Division of Infection Control and Prevention, Osaka University Hospital, Suita City, Osaka, Japan. Electronic address: sekimm-ngs@umin.ac.jp.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Seki
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Umeyama
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Urai
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Kinjo
authors.affiliation: Department of Laboratory Medicine, Osaka University Hospital, Suita City, Osaka, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Nishi
authors.affiliation: Department of Laboratory Medicine, Osaka University Hospital, Suita City, Osaka, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Toyokawa
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan; Department of Bacteriology, Osaka City University, Osaka, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kaneko
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan; Division of Infectious Diseases, Saitama Medical University Kawagoe Hospital, Kawagoe, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ohno
authors.affiliation: Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Toyama, Tokyo, Japan.
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.affiliation: Division of Infection Control and Prevention, Osaka University Hospital, Suita City, Osaka, Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tomono
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001230:Aspergillus / Q000187:drug effects*; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy* / Q000382:microbiology*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents
keywords: Aspergillus lentulus; Beta-tubulin; Caspofungin; Invasive pulmonary aspergillosis; Liposomal amphotericin B; Voriconazole