title: Effect of a high-fat meal on the pharmacokinetics of 300-milligram posaconazole in a solid oral tablet formulation.
abstract: Posaconazole in oral suspension must be taken multiple times a day with food (preferably a high-fat meal) to ensure adequate exposure among patients. We evaluated the effect of food on the bioavailability of a new delayed-release tablet formulation of posaconazole at the proposed clinical dose of 300 mg once daily in a randomized, open-label, single-dose, two-period crossover study with 18 healthy volunteers. When a single 300-mg dose of posaconazole in tablet form (3 tablets × 100 mg) was administered with a high-fat meal, the posaconazole area under the concentration-time curve from 0 to 72 h (AUC0-72) and maximum concentration in plasma (Cmax) increased 51% and 16%, respectively, compared to those after administration in the fasted state. The median time to Cmax (Tmax) shifted from 5 h in the fasted state to 6 h under fed conditions. No serious adverse events were reported, and no subject discontinued the study due to an adverse event. Six of the 18 subjects reported at least one clinical adverse event; all of these events were mild and short lasting. The results of this study demonstrate that a high-fat meal only modestly increases the mean posaconazole exposure (AUC), ∼1.5-fold, after administration of posaconazole tablets, in contrast to the 4-fold increase in AUC observed previously for a posaconazole oral suspension given with a high-fat meal.
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Kersemaekers
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Dogterom
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Jialin
authors.initials: J
authors.lastname: Xu
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA Eugene.marcantonio@merck.com.
authors.forename: Eugene E
authors.initials: EE
authors.lastname: Marcantonio
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Rik
authors.initials: R
authors.lastname: de Greef
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Hetty
authors.initials: H
authors.lastname: Waskin
authors.affiliation: Merck Sharp & Dohme Corp., Kenilworth, New Jersey, USA.
authors.forename: Marlou L P S
authors.initials: ML
authors.lastname: van Iersel
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013607:Tablets / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014230:Triazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D013607:Tablets; D014230:Triazoles; C101425:posaconazole
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