title: Palladium-catalyzed oxidative synthesis of highly functionalized ortholactones.
abstract: A palladium-catalyzed oxidative reaction is reported which converts dihydropyrans to their corresponding ortholactone. The products are formed in good to excellent yields with a very high level of chemoselectivity and functional group tolerance. Mechanistic studies confirm that the reaction proceeds by a Wacker-type mechanism.
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, Belfast, BT9 5AG (UK).
authors.forename: Kate L
authors.initials: KL
authors.lastname: Baddeley
authors.forename: Qun
authors.initials: Q
authors.lastname: Cao
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Muldoon
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Cook
keywords: Wacker-type reaction; aerobic oxidation; ortholactone; palladium; synthetic methods