title: [Regularities in the development of the toxic process in dependence on the stages of disorganization and adaptation].
abstract: At the based of the terms "disorganization" and "adaptation" there was studied the variation of the quantitative criterion of toxic effect--the threshold dose during the experiment with 222 chemicals with the oral toxicity. It is shown that the first manifestation of the effect may occur already in the 5th or 10th or 15th-20th day of intoxication. In the short-term and chronic experiments the dynamics of the toxic process on threshold effect level in time was established to be characterized by four types of models: the growth of the effect (reduction of the threshold doses)--14% of the substances, the absence of the changes in threshold doses--46% of the substances, the apparent weakening of the effect (increase of the threshold dose)--10% of the substances, undulating nature of the threshold doses changes (periodic rise and fall)--30% of the substances. The analysis of these differences with regard to the stage of disorganization and adaptation is carried out. The recommendations for clarifying the procedure of toxicological experiment depending on the dynamics of the toxic process at the threshold level are developed.
authors.forename: Z I
authors.initials: ZI
authors.lastname: Zholdakova
authors.forename: O O
authors.initials: OO
authors.lastname: Sinitsyna
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000426:Alcohol Dehydrogenase / Q000037:antagonists & inhibitors; D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D015386:Hazardous Substances / Q000633:toxicity*; D008954:Models, Biological; D051381:Rats; D020711:Threshold Limit Values; D013997:Time Factors; D018675:Toxicity Tests
chemical_list: D015386:Hazardous Substances; D000426:Alcohol Dehydrogenase; D002374:Catalase