title: Safety and efficacy of rivaroxaban versus warfarin in patients undergoing catheter ablation of atrial fibrillation: a meta-analysis of observational studies.
abstract: The safety and efficacy of rivaroxaban in the periprocedural anticoagulation for patients undergoing catheter ablation of atrial fibrillation is not well established. We sought to systematically review this evidence using data from multiple studies. A thorough literature search was conducted in MEDLINE, EMABSE, Web of knowledge, clinicaltrials.gov, and the Cochrane library up to November 2014. Studies of at least 100 patients in rivaroxaban and warfarin groups were included. Nine observational studies were identified enrolling a total of 4,334 patients (1,210 treated with rivaroxaban and 3,124 with warfarin). The primary outcomes were thromboembolic events and major bleeding. The fixed-effects model meta-analysis was performed and risk ratios (RRs) were calculated. No significant differences were found between patients treated with rivaroxaban and warfarin with regard to thromboembolic events (0.25% rivaroxaban vs. 0.29% warfarin; RR: 0.61; 95%CI: 0.21-1.76; P=0.36) and major bleeding (1.03% rivaroxaban vs. 1.83% warfarin; RR: 0.51; 95%CI: 0.26-1.00; P=0.05). This meta-analysis suggests that patients treated with rivaroxaban have a similar incidence of thromboembolic events and major bleeding compared to warfarin. Signals were seen favoring rivaroxaban; however, considering low events rates, more high-quality studies are necessary to thoroughly compare the two strategies.
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Chuanyu
authors.initials: C
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Muwei
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Xianpei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Datun
authors.initials: D
authors.lastname: Qi
authors.affiliation: Henan Institute of Cardiovascular Epidemiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Peiyuan
authors.initials: P
authors.lastname: Hao
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Zhengzhou University People's Hospital, Zhengzhou, Henan 450003, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhu
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage; D001281:Atrial Fibrillation / Q000628:therapy*; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D065427:Factor Xa Inhibitors / Q000008:administration & dosage; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D064887:Observational Studies as Topic; D061214:Patient Safety; D000069552:Rivaroxaban / Q000008:administration & dosage*; D013923:Thromboembolism / Q000517:prevention & control; D016896:Treatment Outcome; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D014859:Warfarin; D000069552:Rivaroxaban