title: A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer.
abstract: Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional logistic regression adjusted by sex and combinations of study and country for 5942 UADT squamous cell carcinoma case patients and 8086 control patients from nine different studies. All statistical tests were two-sided. rs11571833 was associated with UADT cancers (odds ratio = 2.53, 95% confidence interval = 1.89 to 3.38, P = 3x10(-10)) and was present in European, Latin American, and Indian populations but extremely rare in Japanese populations. The association appeared more apparent in smokers (current or former) compared with never smokers (P het = .026). A robust association between a truncating BRCA2 variant and UADT cancer risk suggests that treatment strategies orientated towards BRCA2 mutations may warrant further investigation in UADT tumors.
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Manon
authors.initials: M
authors.lastname: Delahaye-Sourdeix
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Devasena
authors.initials: D
authors.lastname: Anantharaman
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Maria N
authors.initials: MN
authors.lastname: Timofeeva
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaborieau
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Amélie
authors.initials: A
authors.lastname: Chabrier
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Maxime P
authors.initials: MP
authors.lastname: Vallée
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Ivana
authors.initials: I
authors.lastname: Holcátová
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Richiardi
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Kristina
authors.initials: K
authors.lastname: Kjaerheim
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsagué
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Macfarlane
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Luigi
authors.initials: L
authors.lastname: Barzan
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Cristina
authors.initials: C
authors.lastname: Canova
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Nalin S
authors.initials: NS
authors.lastname: Thakker
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: David I
authors.initials: DI
authors.lastname: Conway
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Ariana
authors.initials: A
authors.lastname: Znaor
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Claire M
authors.initials: CM
authors.lastname: Healy
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ahrens
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: David
authors.initials: D
authors.lastname: Zaridze
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Neonilia
authors.initials: N
authors.lastname: Szeszenia-Dabrowska
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Jolanta
authors.initials: J
authors.lastname: Lissowska
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fabianova
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Ioan Nicolae
authors.initials: IN
authors.lastname: Mates
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bencko
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Lenka
authors.initials: L
authors.lastname: Foretova
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Vladimir
authors.initials: V
authors.lastname: Janout
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Maria Paula
authors.initials: MP
authors.lastname: Curado
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Sergio
authors.initials: S
authors.lastname: Koifman
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Ana
authors.initials: A
authors.lastname: Menezes
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Victor
authors.initials: V
authors.lastname: Wünsch-Filho
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: José
authors.initials: J
authors.lastname: Eluf-Neto
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Leticia
authors.initials: L
authors.lastname: Fernández Garrote
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Marcin
authors.initials: M
authors.lastname: Lener
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Ewa
authors.initials: E
authors.lastname: Jaworowska
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Stefania
authors.initials: S
authors.lastname: Boccia
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Thangarajan
authors.initials: T
authors.lastname: Rajkumar
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Tanuja A
authors.initials: TA
authors.lastname: Samant
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Manoj B
authors.initials: MB
authors.lastname: Mahimkar
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Graham
authors.initials: G
authors.lastname: Byrnes
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.affiliation: : Genetic Cancer Susceptibility Group (MDS, AC, MPV, JDM), Genetic Epidemiology Group (DA, MNT, VG, PBr), Infections and Cancer Epidemiology Group (SF), and Biostatistics Group (GB), International Agency for Research on Cancer, Lyon, France; Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council, Human Genetics Unit, Edinburgh, UK (MNT); Department of Hygiene, Epidemiology and Medical Statistics, University of Athens School of Medicine, Athens, Greece (PL); Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic (IH, VB); University of Turin, Department of Medical Sciences, Unit of Cancer Epidemiology, Turin, Italy (LR); Cancer Registry of Norway, Oslo, Norway (KK); Catalan Institute of Oncology-ICO, IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain (AA, XC); CIBER Epidemiología y Salud Pública, Spain (XC); School of Medicine and Dentistry, University of Aberdeen, Aberdeen, UK (TVM); General Hospital of Pordenone, Pordenone, Italy (LB); Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy (CC); MRC-HPA Centre for Environment and Health, Respiratory Epidemiology and Public Health, National Heart and Lung Institute, Imperial College, London, UK (CC); University of Manchester, School of Dentistry, Manchester, UK (NST); University of Glasgow Dental School, Glasgow, Scotland, UK (DIC); Croatian National Cancer Registry, Croatian National Institute of Public Health, Zagreb, Croatia (AZ); Trinity College School of Dental Science, Dublin, Ireland (CMH); Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany (WA); Faculty of Mathematics and Computer Science, University of Bremen, Bremen, Germany (WA); Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russian Federation (DZ); Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland (NSD); Department of Ca
authors.forename: James D
authors.initials: JD
authors.lastname: McKay
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology; D024682:BRCA2 Protein / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human
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