title: An unusual complex karyotype in myopericytoma.
abstract: BACKGROUND
  Myopericytoma is a perivascular neoplasm commonly found in the skin and soft tissue of extremities. These lesions often exhibit concentric vascular proliferation of spindle shaped myoid cells.
  
  
  RESULTS
  We present a case of a 76-year old male who was diagnosed with myopericytoma and subsequent cytogenetic analysis found a highly abnormal karyotype. This karyotype includes cytogenetic mutations that have not been described in previous case studies of myopericytoma.
  
  
  CONCLUSIONS
  Some of these aberrations occur on genes that are involved in hedgehog signaling as well as pericyte proliferation, indicating a potential pericyte origin for myopericytoma tumors.
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Le
authors.initials: L
authors.lastname: Chang
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Swati
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Tirado
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
keywords: Complex karyotype; Myopericytoma; Pericyte; Perivascular tumor
references.citation: J Cutan Pathol. 1996 Oct;23(5):445-57
references.pmid: 8915853
references.citation: Gene. 1998 Mar 16;209(1-2):1-11
references.pmid: 9524201
references.citation: Am J Surg Pathol. 2006 Jan;30(1):104-13
references.pmid: 16330949
references.citation: Cancer Genet Cytogenet. 2002 May;135(1):96-100
references.pmid: 12072207
references.citation: J Clin Pathol. 2006 Jan;59(1):67-73
references.pmid: 16394283
references.citation: BMC Cancer. 2004 Aug 04;4:43
references.pmid: 15294024
references.citation: Science. 1996 Jun 14;272(5268):1668-71
references.pmid: 8658145
references.citation: Medicine (Baltimore). 1987 Mar;66(2):98-113
references.pmid: 3547011
references.citation: Cancer Res. 2013 Apr 1;73(7):2139-49
references.pmid: 23338608
references.citation: Am J Pathol. 2004 May;164(5):1645-53
references.pmid: 15111311
references.citation: Br J Cancer. 2012 Nov 6;107(10 ):1702-13
references.pmid: 23047550
references.citation: Science. 1996 Oct 11;274(5285):255-9
references.pmid: 8824192
references.citation: Am J Med Genet A. 2003 Nov 15;123A(1):5-28
references.pmid: 14556242
references.citation: Nature. 1999 Feb 18;397(6720):617-21
references.pmid: 10050855
references.citation: Neuro Oncol. 2005 Oct;7(4):452-64
references.pmid: 16212810
references.citation: Hum Pathol. 2012 Sep;43(9):1524-9
references.pmid: 22575261
references.citation: Acta Cytol. 1995 Jul-Aug;39(4):613-22
references.pmid: 7543232
references.citation: J Exp Med. 2004 Mar 15;199(6):753-61
references.pmid: 15024045
references.citation: Cancer Res. 2004 Feb 1;64(3):934-41
references.pmid: 14871823
references.citation: Stem Cells Dev. 2012 May 20;21(8):1299-308
references.pmid: 21861688
references.citation: Genes Chromosomes Cancer. 2006 Oct;45(10):918-32
references.pmid: 16858696