title: [Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group].
abstract: Genotype and allele frequencies of uncoupling proteins 2 and 3 genes (UCP2 and UCP3) and peroxisome proliferator-activated receptors genes (PPARA, PPARD and PPARG) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included UCP2 (Ala55Val), UCP3 (C-55T), PPARA (G/C), PPARD (+294T/C), and PPARG (Pro12Ala). The G allele and the G/G genotype (PPARA) were overrepresented in the group of survivors and C/C (UCP3) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster. Feasible protective effects of PPARA gene allele G and C allele of UCP2 genes are briefly discussed.
authors.forename: I V
authors.initials: IV
authors.lastname: Poliakova
authors.forename: O S
authors.initials: OS
authors.lastname: Glotov
authors.forename: L P
authors.initials: LP
authors.lastname: Khoroshinina
authors.forename: L V
authors.initials: LV
authors.lastname: Tur'eva
authors.forename: T É
authors.initials: TÉ
authors.lastname: Ivashchenko
authors.forename: V S
authors.initials: VS
authors.lastname: Baranov
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002947:Cities; D003627:Data Interpretation, Statistical; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008136:Longevity / Q000235:genetics*; D008297:Male; D044342:Malnutrition / Q000235:genetics*; D024101:Mitochondrial Proteins / Q000235:genetics*; D047493:PPAR alpha / Q000235:genetics*; D047494:PPAR delta / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012426:Russia; D017741:Survivors; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3; D047789:World War II
chemical_list: D007473:Ion Channels; D024101:Mitochondrial Proteins; D047493:PPAR alpha; D047494:PPAR delta; D047495:PPAR gamma; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3