title: Micro-terminator: 'Hasta la vista, lncRNA!'.
abstract: Transcriptional termination is an important yet incompletely understood aspect of gene expression. Proudfoot, Jopling and colleagues now identify a new Microprocessor-mediated mechanism of transcriptional termination, which acts specifically on long noncoding transcripts that serve as microRNA precursors.
authors.affiliation: Division 'RNA Biology &Cancer', German Cancer Research Center (DKFZ), Heidelberg, Germany, and the Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Diederichs
mesh_terms: D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008957:Models, Genetic; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
references.citation: Nat Rev Mol Cell Biol. 2011 May;12(5):283-94
references.pmid: 21487437
references.citation: Cancer Cell. 2010 Jan 19;17(1):28-40
references.pmid: 20060366
references.citation: Gene. 2007 Jul 15;396(2):373-90
references.pmid: 17531405
references.citation: PLoS Genet. 2013 Apr;9(4):e1003373
references.pmid: 23593011
references.citation: Nature. 2003 Sep 25;425(6956):415-9
references.pmid: 14508493
references.citation: Nature. 2004 Nov 25;432(7016):522-5
references.pmid: 15565158
references.citation: Genome Res. 2009 Mar;19(3):347-59
references.pmid: 19106332
references.citation: Mol Cell Biol. 2009 Oct;29(20):5632-8
references.pmid: 19667074
references.citation: Cell. 2012 Sep 14;150(6):1147-57
references.pmid: 22980978
references.citation: RNA Biol. 2011 Nov-Dec;8(6):1105-14
references.pmid: 21955497
references.citation: Nucleic Acids Res. 2014 Jan;42(1):264-75
references.pmid: 24097444
references.citation: Cell. 2012 Apr 27;149(3):538-53
references.pmid: 22502866
references.citation: Genes Dev. 2014 Mar 1;28(5):491-501
references.pmid: 24532688
references.citation: Genome Res. 2012 Oct;22(10):2054-66
references.pmid: 22722342
references.citation: Cell. 2009 Aug 21;138(4):673-84
references.pmid: 19703394
references.citation: Nat Struct Mol Biol. 2015 Apr;22(4):319-27
references.pmid: 25730776
references.citation: Nat Rev Genet. 2013 Jul;14(7):496-506
references.pmid: 23774734
references.citation: Nat Struct Mol Biol. 2008 Sep;15(9):902-9
references.pmid: 19172742
references.citation: Genes Dev. 2009 Feb 15;23(4):466-81
references.pmid: 19240133
references.citation: Nat Cell Biol. 2009 Mar;11(3):228-34
references.pmid: 19255566
references.citation: Cell. 2008 Nov 28;135(5):919-32
references.pmid: 19041754
references.citation: J Mol Med (Berl). 2013 Jul;91(7):791-801
references.pmid: 23529762
references.citation: Cancer Res. 2013 Feb 1;73(3):1180-9
references.pmid: 23243023
references.citation: RNA. 2005 Mar;11(3):241-7
references.pmid: 15701730