title: An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.
abstract: The roles of both kainate receptors (KARs) and metabotropic glutamate receptors (mGluRs) in mossy fiber long-term potentiation (MF-LTP) have been extensively studied in hippocampal brain slices, but the findings are controversial. In this study, we have addressed the roles of both mGluRs and KARs in MF-LTP in anesthetized rats. We found that MF-LTP could be induced in the presence of either GluK1-selective KAR antagonists or group I mGluR antagonists. However, LTP was inhibited when the group I mGluRs and the GluK1-KARs were simultaneously inhibited. Either mGlu1 or mGlu5 receptor activation is sufficient to induce this form of LTP as selective inhibition of either subtype alone, together with the inhibition of KARs, did not inhibit MF-LTP. These data suggest that mGlu1 receptors, mGlu5 receptors, and GluK1-KARs are all engaged during high-frequency stimulation, and that the activation of any one of these receptors alone is sufficient for the induction of MF-LTP in vivo.
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: James L
authors.initials: JL
authors.lastname: Wallis
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Irvine
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: David E
authors.initials: DE
authors.lastname: Jane
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: David
authors.initials: D
authors.lastname: Lodge
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: Graham L
authors.initials: GL
authors.lastname: Collingridge
authors.affiliation: Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
authors.forename: Zuner A
authors.initials: ZA
authors.lastname: Bortolotto
mesh_terms: D000818:Animals; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D064529:Receptor, Metabotropic Glutamate 5 / Q000037:antagonists & inhibitors / Q000502:physiology*; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D064529:Receptor, Metabotropic Glutamate 5; D018092:Kainic Acid Receptors; D018094:Receptors, Metabotropic Glutamate; C578937:Grm5 protein, rat; C104077:metabotropic glutamate receptor type 1
keywords: CA3; LTP; dentate; granule cells
references.citation: Neuron. 2001 Jan;29(1):209-16
references.pmid: 11182092
references.citation: Nat Neurosci. 2003 Oct;6(10):1058-63
references.pmid: 12947409
references.citation: Brain Res Bull. 1991 Aug;27(2):219-23
references.pmid: 1660336
references.citation: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10290-4
references.pmid: 7937943
references.citation: J Neurosci. 2004 Nov 10;24(45):10093-8
references.pmid: 15537878
references.citation: Neuron. 2001 Nov 20;32(4):697-709
references.pmid: 11719209
references.citation: Br J Pharmacol. 2000 Dec;131(7):1429-37
references.pmid: 11090117
references.citation: J Neurosci. 2010 Sep 29;30(39):12996-3004
references.pmid: 20881117
references.citation: Nat Neurosci. 1999 Jul;2(7):625-33
references.pmid: 10404192
references.citation: Eur J Pharmacol. 1993 Jan 15;244(2):195-7
references.pmid: 8381746
references.citation: Behav Brain Res. 2012 Mar 17;228(2):406-14
references.pmid: 22203159
references.citation: Neuropharmacology. 1995 Nov;34(11):1567-72
references.pmid: 8606804
references.citation: Nature. 1995 Sep 14;377(6545):115-8
references.pmid: 7675078
references.citation: Eur J Neurosci. 1994 Jun 1;6(6):1050-4
references.pmid: 7952274
references.citation: Neuropharmacology. 1999 Oct;38(10):1493-503
references.pmid: 10530811
references.citation: Neurosci Lett. 1986 Sep 25;70(1):132-7
references.pmid: 3022192
references.citation: J Physiol. 1996 Jun 1;493 ( Pt 2):447-55
references.pmid: 8782108
references.citation: Eur J Neurosci. 2005 Jan;21(2):411-21
references.pmid: 15673440
references.citation: Neurochem Int. 2012 Sep;61(4):482-9
references.pmid: 22564530
references.citation: Nat Neurosci. 2001 Feb;4(2):125-6
references.pmid: 11175870
references.citation: Nature. 1993 Jan 7;361(6407):31-9
references.pmid: 8421494
references.citation: Nature. 1993 May 27;363(6427):347-50
references.pmid: 8388549
references.citation: J Med Chem. 2012 Jan 12;55(1):327-41
references.pmid: 22111545
references.citation: Neuron. 2003 Jul 17;39(2):327-41
references.pmid: 12873388
references.citation: Neuropharmacology. 1997 Nov-Dec;36(11-12):1533-8
references.pmid: 9517423
references.citation: Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12181-6
references.pmid: 17620617
references.citation: J Neurosci Methods. 2007 May 15;162(1-2):346-56
references.pmid: 17306885
references.citation: J Neurophysiol. 2005 May;93(5):2668-73
references.pmid: 15548625
references.citation: Neuropharmacology. 2004 Jul;47(1):46-64
references.pmid: 15165833
references.citation: Cereb Cortex. 2010 May;20(5):1121-30
references.pmid: 19903765
references.citation: Neuropharmacology. 2009 Jan;56(1):121-30
references.pmid: 18789344
references.citation: Sci Rep. 2011;1:103
references.pmid: 22355621
references.citation: Int J Gen Med. 2012;5:935-42
references.pmid: 23204857
references.citation: Nat Rev Neurosci. 2005 Nov;6(11):863-76
references.pmid: 16261180
references.citation: Mol Brain. 2013;6:5
references.pmid: 23339575
references.citation: Hippocampus. 2012 Jan;22(1):1-8
references.pmid: 20848610
references.citation: Brain Res. 2001 May 18;901(1-2):237-46
references.pmid: 11368972
references.citation: Neuroreport. 1991 Jun;2(6):333-6
references.pmid: 1680482
references.citation: Cereb Cortex. 2004 Feb;14(2):189-98
references.pmid: 14704216
references.citation: Neuropharmacology. 2009 Jan;56(1):90-113
references.pmid: 18793656
references.citation: Br J Pharmacol. 1983 Jun;79(2):565-75
references.pmid: 6317114
references.citation: Neuropharmacology. 1999 Oct;38(10):1431-76
references.pmid: 10530808
references.citation: Neuropharmacology. 2009 Jan;56(1):131-40
references.pmid: 18761361
references.citation: Nature. 1999 Nov 18;402(6759):297-301
references.pmid: 10580501
references.citation: Neuroscience. 1998 Oct;86(3):709-21
references.pmid: 9692711