title: The Role of Ubiquitination in Regulation of Innate Immune Signaling.
abstract: Ubiquitination, also denoted ubiquitylation, is a posttranslational modification that has been implicated in the regulation of both innate and adaptive immune responses. Ubiquitination plays crucial roles in innate immune signaling by ensuring the proper orchestration of several signaling mediators that constitute a functional immune response. Herein, we briefly summarize the latest discoveries concerning the molecular ubiquitination-related machinery that senses, assembles, and disassembles innate immune signaling mediators.
authors.affiliation: State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, 430070, P. R. China.
authors.forename: Ali
authors.initials: A
authors.lastname: Zohaib
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Duan
authors.forename: Bibo
authors.initials: B
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.forename: Shengfeng
authors.initials: S
authors.lastname: Wan
authors.forename: Huanchun
authors.initials: H
authors.lastname: Chen
authors.forename: Xueqin
authors.initials: X
authors.lastname: Liu
authors.forename: Shengbo
authors.initials: S
authors.lastname: Cao
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology; D054875:Ubiquitination
chemical_list: D051193:Toll-Like Receptors