title: The evolution of animal welfare and the 3Rs in Brazil, China, and India.
abstract: Increasingly, scientific collaborations and contracts cross country borders. The need for assurance that the quality of animal welfare and the caliber of animal research conducted are equivalent among research partners around the globe is of concern to the scientific and laboratory animal medicine communities, the general public, and other key stakeholders. Therefore, global harmonization of animal care and use standards and practices, with the welfare of the animals as a cornerstone, is essential. In the evolving global landscape of enhanced attention to animal welfare, a widely accepted path to achieving this goal is the successful integration of the 3Rs in animal care and use programs. Currently, awareness of the 3Rs, their implementation, and the resulting animal care and use standards and practices vary across countries. This variability has direct effects on the animals used in research and potentially the data generated and may also have secondary effects on the country's ability to be viewed as a global research partner. Here we review the status of implementation of the 3Rs worldwide and focus on 3 countries-Brazil, China and India-with increasing economic influence and an increasing footprint in the biomedical research enterprise.
authors.affiliation: Association for Assessment and Accreditation of Laboratory Animal Care International, Frederick, Maryland, USA. kbayne@aaalac.org.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Bayne
authors.affiliation: Indian Institute of Science, Bangalore, Karnataka, India.
authors.forename: Gudde S
authors.initials: GS
authors.lastname: Ramachandra
authors.affiliation: Universidade Federal de Goiás, Goiânia-Goiás, Brazil.
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Rivera
authors.affiliation: GlaxoSmithKline R&D China, Shanghai, PR China.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Wang
mesh_terms: D032761:Animal Experimentation; D000822:Animal Husbandry; D000827:Animal Welfare / Q000592:standards; D000818:Animals; D001938:Brazil; D002681:China; D017408:Guidelines as Topic; D007194:India
references.citation: Vet Rec. 2004 Apr 10;154(15):467-70
references.pmid: 15143737
references.citation: Chemosphere. 2013 Jan;90(3):1281-8
references.pmid: 23098581
references.citation: Altern Lab Anim. 2013 Nov;41(5):351-7
references.pmid: 24329743
references.citation: PLoS Biol. 2014 Jan;12(1):e1001756
references.pmid: 24409096
references.citation: Wei Sheng Yan Jiu. 2004 Jul;33(4):515-7
references.pmid: 15461295
references.citation: Cancer Res. 1985 Mar;45(3):945-77
references.pmid: 3971387
references.citation: ALTEX. 2005;22(1):3-6
references.pmid: 15719144
references.citation: Altern Lab Anim. 2005 Dec;33(6):670-2
references.pmid: 16419364
references.citation: Hepatology. 2007 May;45(5):1229-39
references.pmid: 17464996
references.citation: Altern Lab Anim. 2008 Dec;36(6):705-8
references.pmid: 19154096
references.citation: Acta Cir Bras. 2009 Jan-Feb;24(1):69-74
references.pmid: 19169547
references.citation: Altern Lab Anim. 2009 Apr;37(2):197-207
references.pmid: 19453216
references.citation: Science. 2009 Jun 26;324(5935):1643-4
references.pmid: 19556485
references.citation: Altern Lab Anim. 2009 Jul;37(3):297-303
references.pmid: 19678731
references.citation: Am J Bioeth. 2009 Dec;9(12):55-9
references.pmid: 20013503
references.citation: ILAR J. 2009;51(1):e1-e11
references.pmid: 20075493
references.citation: Altern Lab Anim. 2010 Mar;38(1):53-69
references.pmid: 20377304
references.citation: ALTEX. 2009;26(4):303-6
references.pmid: 20383476
references.citation: Altern Lab Anim. 2010 Jun;38(3):239-44
references.pmid: 20602540
references.citation: PLoS Biol. 2010;8(6):e1000412
references.pmid: 20613859
references.citation: ILAR J. 2011;52(1):E8-15
references.pmid: 21447857
references.citation: PLoS One. 2011;6(8):e22478
references.pmid: 21857928
references.citation: Altern Lab Anim. 2011 Oct;39(5):429-47
references.pmid: 22103937
references.citation: J Am Assoc Lab Anim Sci. 2011 Nov;50(6):901-3
references.pmid: 22330784
references.citation: Braz J Otorhinolaryngol. 2012 Apr;78(2):128-31
references.pmid: 22499381
references.citation: Altern Lab Anim. 2004 Jun;32 Suppl 1B:411-5
references.pmid: 23581110