title: PNIPAAm-MAA nanoparticles as delivery vehicles for curcumin against MCF-7 breast cancer cells.
abstract: Breast cancer is the most frequently occurring cancer among women throughout the world. Natural compounds such as curcumin hold promise to treat a variety of cancers including breast cancer. However, curcumin's therapeutic application is limited, due to its rapid degradation and poor aqueous solubility. On the other hand, previous studies have stated that drug delivery using nanoparticles might improve the therapeutic response to anticancer drugs. Poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAAm-MAA) is one of the hydrogel copolymers utilized in the drug delivery system for cancer therapy. The aim of this study was to examine the cytotoxic potential of curcumin encapsulated within the NIPAAm-MAA nanoparticle, on the MCF-7 breast cancer cell line. In this work, polymeric nanoparticles were synthesized through the free radical mechanism, and curcumin was encapsulated into NIPAAm-MAA nanoparticles. Then, the cytotoxic effect of curcumin-loaded NIPAAm-MAA on the MCF-7 breast cancer cell line was measured by MTT assays. The evaluation of the results showed that curcumin-loaded NIPAAm-MAA has more cytotoxic effect on the MCF-7 cell line and efficiently inhibited the growth of the breast cancer cell population, compared with free curcumin. In conclusion, this study indicates that curcumin-loaded NIPAAm-MAA suppresses the growth of the MCF-7 cell line. Overall, it is concluded that encapsulating curcumin into the NIPAAm-MAA copolymer could open up new avenues for breast cancer treatment.
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Vahideh
authors.initials: V
authors.lastname: Zeighamian
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|c Department of Clinical Biochemistry and Laboratory Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Darabi
authors.affiliation: d Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|e Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|c Department of Clinical Biochemistry and Laboratory Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rahmati-Yamchi
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.|c Department of Clinical Biochemistry and Laboratory Sciences , Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Zarghami
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Badrzadeh
authors.affiliation: d Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Salehi
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Fatemeh Sadat Tabatabaei
authors.initials: FS
authors.lastname: Mirakabad
authors.affiliation: a Department of Medical Biotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mortaza
authors.initials: M
authors.lastname: Taheri-Anganeh
mesh_terms: D000178:Acrylamides / Q000737:chemistry* / Q000633:toxicity; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D065546:Drug Liberation; D006801:Humans; D007700:Kinetics; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D011109:Polymethacrylic Acids / Q000737:chemistry* / Q000633:toxicity
chemical_list: D000178:Acrylamides; D000970:Antineoplastic Agents; D004337:Drug Carriers; D011109:Polymethacrylic Acids; C085085:poly(N-isopropylacrylamide-co-methacrylic acid); D003474:Curcumin
keywords: PNIPAAm-MAA; breast cancer; curcumin; drug delivery