title: Effects of metformin on cell kinetic parameters of MCF-7 breast cancer cells in vitro.
abstract: In this study, the antiproliferative effects of the metformin was evaluated on MCF-7 Cells (human breast adenocarcinoma cell line). For this purpose cell kinetic parameters including cell proliferation assay, mitotic index and labelling index analysis were used. 30 μM, 65 μM and 130 μM Metformin doses were applied to cells for 24, 48 and 72 hours. The results showed that there was a significant decrease in cell proliferation, mitotic index and labelling index for all experimental groups (p<0.05) for all applications.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey E-mail : topcul@istanbul.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Topcul
authors.forename: Idil
authors.initials: I
authors.lastname: Cetin
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D061986:MCF-7 Cells; D008687:Metformin / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin