title: Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins.
abstract: Pomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.
authors.affiliation: Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente , México, D. F. , México .
authors.forename: María Eva
authors.initials: ME
authors.lastname: González-Trujano
authors.forename: Francisco
authors.initials: F
authors.lastname: Pellicer
authors.forename: Pedro
authors.initials: P
authors.lastname: Mena
authors.forename: Diego A
authors.initials: DA
authors.lastname: Moreno
authors.forename: Cristina
authors.initials: C
authors.lastname: García-Viguera
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D029561:Lythraceae; D008297:Male; D051379:Mice; D059226:Nociceptive Pain / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D059808:Polyphenols; C013515:ellagitannin
keywords: Anti-inflammatory; anthocyanin; antinociception; ellagitannin; formalin test; gastroprotection