title: Low levels of serum uric Acid increase the risk of low bone mineral density in young male patients with ankylosing spondylitis.
abstract: OBJECTIVE
  Uric acid (UA) has antiosteoporotic effects in postmenopausal women. This study investigated the association between serum UA levels and bone mineral density (BMD) in young male patients with ankylosing spondylitis (AS).
  
  
  METHODS
  One hundred fifty patients who fulfilled the modified New York criteria for the classification of AS were analyzed. All patients were male and under 50 years of age. BMD, serum UA concentrations, clinical variables, and radiographic progression were assessed. The associations between UA and BMD at the lumbar spine and hip were evaluated using multiple linear regression analysis. Multivariate logistic regression analyses were performed to identify risk factors associated with low BMD.
  
  
  RESULTS
  Mean serum UA concentration in the 150 patients with AS was 5.5 ± 1.3 mg/dl. BMD at the lumbar spine, but not at the total hip and femoral neck, increased with increasing serum UA tertiles (p = 0.033). The significant positive association between serum UA and BMD at the lumbar spine remained after adjustment for confounding factors (β = 0.185, p = 0.014, adjusted R(2) = 0.310). Multiple logistic regression analyses showed that lower UA concentrations (OR 4.02, 95% CI 1.34-12.3) and body mass index and increased erythrocyte sedimentation rate were independently associated with the risk of low BMD.
  
  
  CONCLUSIONS
  Lower serum UA levels are associated with lower BMD in young male patients with AS. UA may be a novel predictive marker or therapeutic target in patients with AS.
authors.affiliation: From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; and the Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital, Incheon, South Korea.K.Y. Kang, MD, PhD; Y.S. Hong, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, and Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital; S.H. Park, MD, PhD; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
authors.forename: Kwi Young
authors.initials: KY
authors.lastname: Kang
authors.affiliation: From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; and the Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital, Incheon, South Korea.K.Y. Kang, MD, PhD; Y.S. Hong, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, and Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital; S.H. Park, MD, PhD; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
authors.forename: Yeon Sik
authors.initials: YS
authors.lastname: Hong
authors.affiliation: From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; and the Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital, Incheon, South Korea.K.Y. Kang, MD, PhD; Y.S. Hong, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, and Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital; S.H. Park, MD, PhD; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea.
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Park
authors.affiliation: From the Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul; and the Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital, Incheon, South Korea.K.Y. Kang, MD, PhD; Y.S. Hong, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, and Division of Rheumatology, Department of Internal Medicine, College of Medicine, Incheon Saint Mary's Hospital; S.H. Park, MD, PhD; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea. juji@catholic.ac.kr.
authors.forename: Ji Hyeon
authors.initials: JH
authors.lastname: Ju
mesh_terms: D000328:Adult; D000367:Age Factors; D015519:Bone Density / Q000502:physiology; D016001:Confidence Intervals; D016208:Databases, Factual; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010024:Osteoporosis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D013167:Spondylitis, Ankylosing / Q000097:blood* / Q000503:physiopathology*; D014527:Uric Acid / Q000097:blood* / Q000378:metabolism
chemical_list: D014527:Uric Acid
keywords: ANKYLOSING SPONDYLITIS; ANTIOXIDANT; BONE MINERAL DENSITY; OSTEOPOROSIS; URIC ACID