title: Korean studies on blood stasis: an overview.
abstract: Blood stasis is one of the important pathological concepts in Korean medicine. We analyzed the Korean studies concerning blood stasis. We searched for articles in eight electronic databases from their inception to September, 2014. We included reviews, clinical studies, and preclinical studies that had studied blood stasis and excluded articles in which blood stasis was not mentioned or in which the original authors had not explained blood stasis. Of 211 total included studies, 19 were reviews, 52 were clinical studies, and 140 were preclinical articles. "Stagnant blood within the body" was the most frequently mentioned phrase of the traditional concept of blood stasis. Traumatic injury was the most frequently studied disease/condition in the clinical studies. In the preclinical studies, coagulopathy was studied most frequently, followed by hyperviscosity, hyperlipidemia, inflammation, neoplasm, ischemic brain injury, and atherosclerosis. Hyeolbuchukeo-tang and Angelicae Gigantis Radix were the most frequent formula and single herb, respectively, used in the blood stasis researches. The results showed that blood stasis was mainly recognized as disorder of circulation and many studies showed the effectiveness of activating blood circulating herbs for diseases and pathologies such as traumatic injury or coagulopathy. Further studies are needed in the pathologic mechanisms and various diseases of blood stasis.
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Bongki
authors.identifier: 0000-0003-2647-7678
authors.initials: B
authors.lastname: Park
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Sooseong
authors.identifier: 0000-0001-6948-892X
authors.initials: S
authors.lastname: You
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Jeeyoun
authors.initials: J
authors.lastname: Jung
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Ju Ah
authors.initials: JA
authors.lastname: Lee
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Yun
authors.affiliation: Medical Research Division, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
authors.forename: Myeong Soo
authors.identifier: 0000-0001-6651-7641
authors.initials: MS
authors.lastname: Lee
references.citation: J Ethnopharmacol. 2008 May 22;117(3):473-7
references.pmid: 18417308
references.citation: Chin J Integr Med. 2012 Dec;18(12):891-6
references.pmid: 23238996
references.citation: Evid Based Complement Alternat Med. 2013;2013:130702
references.pmid: 24371451
references.citation: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Nov;32(11):1500-2
references.pmid: 23359973
references.citation: Complement Ther Med. 2014 Apr;22(2):391-9
references.pmid: 24731911
references.citation: Evid Based Complement Alternat Med. 2008 Dec;5(4):463-74
references.pmid: 18955217
references.citation: Evid Based Complement Alternat Med. 2013;2013:416932
references.pmid: 23878597
references.citation: Evid Based Complement Alternat Med. 2013;2013:510208
references.pmid: 23762142
references.citation: Zhong Yao Cai. 2013 May;36(5):780-3
references.pmid: 24218973
references.citation: BMC Complement Altern Med. 2014 Jan 02;14:2
references.pmid: 24383676
references.citation: Chin J Integr Med. 2014 Jul;20(7):490-5
references.pmid: 24972576
references.citation: Chin J Integr Med. 2014 Jul;20(7):483-9
references.pmid: 24610412
references.citation: Zhong Xi Yi Jie He Xue Bao. 2010 Sep;8(9):848-52
references.pmid: 20836975
references.citation: Chin J Integr Med. 2014 Mar;20(3):163-9
references.pmid: 23918233
references.citation: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32(10):1420-2
references.pmid: 23163160
references.citation: Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Oct;32(10):1313-8
references.pmid: 23163136
references.citation: Zhongguo Zhong Yao Za Zhi. 2014 Jan;39(1):113-20
references.pmid: 24754179
references.citation: Zhongguo Zhong Yao Za Zhi. 2012 May;37(9):1327-31
references.pmid: 22803386
references.citation: Complement Ther Med. 2013 Dec;21(6):633-40
references.pmid: 24280472