title: Effects of an Oral Nutritional Supplementation Plus Physical Exercise Intervention on the Physical Function, Nutritional Status, and Quality of Life in Frail Institutionalized Older Adults: The ACTIVNES Study.
abstract: OBJECTIVE
  The objective of this study was to assess the effects of a hyperproteic, hypercaloric oral nutritional supplement with prebiotic fiber, vitamin D, and calcium, plus a standardized physical intervention, in the functional status, strength, nutritional status, and quality of life of frail institutionalized older adults.
  
  
  METHODS
  Multicentric prospective observational study under usual clinical practice conditions.
  
  
  METHODS
  Four nursing homes from Burgos (2), Albacete, and Madrid, Spain.
  
  
  METHODS
  Participants included 91 institutionalized older adults (age ≥70), able to walk 50 m, and meeting at least 3 of the Fried frailty phenotype criteria.
  
  
  METHODS
  Daily intake of two 200-mL bottles of an oral nutritional supplement, each bottle containing 300 kcal, 20 g protein, 3 g fiber, 500 IU vitamin D, and 480 mg calcium, plus a standardized physical exercise training consisting of flexibility, balance, and strengthening exercises for arms and legs, 5 days per week.
  
  
  METHODS
  Short Physical Performance Battery (SPPB), Short-Form-Late-Life Function and Disability Instrument (SF-LLFDI) function subscale, handgrip strength, EuroQoL-5 Dimensions visual analogic scale (EQ5DVAS), weight, body mass index (BMI), and Short-Form Mini Nutritional Assessment (MNA-SF) at baseline and 6 and 12 weeks.
  
  
  RESULTS
  Forty-eight participants (52.7%) improved at least 1 point in the SPPB at week 6, and 44 (48.4%) did so at week 12; 39 participants (42.9%) improved at least 2 points in the SF-LLFDI at week 6, and 46 (50.5%) at week 12. Participants improved their quality of life measured with the EQ5DVAS by 6% (95% confidence interval [CI] 3%-10%) at week 6, and by 5% (95% CI 0%-10%) at week 12. They also improved their nutritional status (weight gain, BMI increase, and higher MNA-SF scores at 6- and 12-week follow-up). This improvement was higher in participants with more frailty criteria, lower functional level, lower vitamin D levels, and poorer nutritional status.
  
  
  CONCLUSIONS
  A 12-week intervention with oral nutritional supplementation plus physical exercise improves function, nutritional status, and quality of life in frail institutionalized older adults.
authors.affiliation: Geriatrics Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. Electronic address: pabizanda@sescam.jccm.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda
authors.affiliation: Centro Residencial Jardín de Tardajos, Burgos, Spain.
authors.forename: Mateo Díez
authors.initials: MD
authors.lastname: López
authors.affiliation: Department of Medicine, Orpea Group, Madrid, Spain.
authors.forename: Victoria Pérez
authors.initials: VP
authors.lastname: García
authors.affiliation: Residencia Núñez de Balboa, Geriatrics Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
authors.forename: Juan de Dios
authors.initials: Jde D
authors.lastname: Estrella
authors.affiliation: Residencia de Ancianos de la Diputación Provincial de Burgos, Geriatrics Department, Burgos, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: da Silva González
authors.affiliation: Medical Affairs Department, Nestlé Health Science-Nestlé España, Barcelona, Spain.
authors.forename: Núria Barcons
authors.initials: NB
authors.lastname: Vilardell
authors.affiliation: Medical Affairs Department, Nestlé Health Science-Nestlé España, Barcelona, Spain.
authors.forename: Krysmarú Araujo
authors.initials: KA
authors.lastname: Torres
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D019587:Dietary Supplements; D015444:Exercise; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D009735:Nursing Homes; D009752:Nutritional Status; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins
keywords: Frail elderly; function; nursing homes; nutrition enteral; physical exercise