title: [Exfoliative esophagitis while taking dabigatran].
abstract: History | A 77-year-old woman was admitted with severe chest pain, heartburn, dysphagia and odynophagia. She had been on dabigatran for 13 months due to atrial fibrillation and arterial hypertension. Investigations and findings | Endoscopy of the esophagus revealed sloughing of mucosal casts, predominantly in the upper half of the organ. Treatment and course | The patient was placed on pantoprazol, local anaesthetic antacid and i. v. fluids. Dabigatran was discontinued. The symptoms disappeared within 3 days. Control endoscopy after 12 days showed complete healing of the esophageal mucosa. Conclusion | The intake of dabigatran was associated with exfoliative esophagitis, possibly due to caustic tissue damage by prolonged drug contact.
authors.affiliation: Medizinische Klinik, Schwerpunkt Gastroenterologie / Rheumatologie.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Scheppach
authors.affiliation: Medizinische Klinik, Schwerpunkt Kardiologie / Internistische Intensivmedizin, Krankenhaus Juliusspital Würzburg.
authors.forename: Malte
authors.initials: M
authors.lastname: Meesmann
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000991:Antithrombins / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy*; D001562:Benzimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D000069604:Dabigatran; D016145:Endoscopy, Digestive System; D004941:Esophagitis / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D000077402:Pantoprazole; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000077402:Pantoprazole; D000069604:Dabigatran