title: Sex and race and/or ethnicity differences in patients undergoing radiofrequency ablation for Barrett's esophagus: results from the U.S. RFA Registry.
abstract: BACKGROUND
  Little is known about differences in Barrett's esophagus (BE) characteristics by sex and race and/or ethnicity or these differences in response to radiofrequency ablation (RFA).
  
  
  OBJECTIVE
  We compared disease-specific characteristics, treatment efficacy, and safety outcomes by sex and race and/or ethnicity in patients treated with RFA for BE.
  
  
  METHODS
  The U.S. RFA patient registry is a multicenter collaboration reporting processes and outcomes of care for patients treated with RFA for BE.
  
  
  METHODS
  Patients enrolled with BE.
  
  
  METHODS
  RFA.
  
  
  METHODS
  We assessed safety (stricture, bleeding, perforation, hospitalization), efficacy (complete eradication of intestinal metaplasia [CEIM]), complete eradication of dysplasia, and number of treatments to CEIM by sex and race and/or ethnicity.
  
  
  RESULTS
  Among 5521 patients (4052 men; 5126 white, 137 Hispanic, 82 African American, 40 Asian, 136 heritage not identified), women were younger (60.0 vs 62.1 years) and had shorter BE segments (3.2 vs 4.4 cm) and less dysplasia (37% vs 57%) than did men. Women were almost twice as likely to stricture (odds ratio 1.7; 95% confidence interval, 1.2-2.3). Although white patients were predominantly male, about half of African Americans and Asians with BE were female. African Americans and Asians had less dysplasia than white patients. Asians and African Americans had more strictures than did white patients. There were no sex or race differences in efficacy.
  
  
  CONCLUSIONS
  Observational study with non-mandated paradigms, no central laboratory for reinterpretation of pathology.
  
  
  CONCLUSIONS
  In the U.S. RFA patient registry, women had shorter BE segments and less-aggressive histology. The usual tendency toward BE in men was absent in African Americans and Asians. Posttreatment stricture was more common among women and Asians. RFA efficacy did not differ by sex or race.
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Sarina
authors.initials: S
authors.lastname: Pasricha
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Bulsiewicz
authors.affiliation: Dartmouth University School of Medicine, Hanover, New Hampshire, USA.
authors.forename: Richard I
authors.initials: RI
authors.lastname: Rothstein
authors.affiliation: Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Infantolino
authors.affiliation: University of Texas School of Medicine, Houston, Texas, USA.
authors.forename: Atilla
authors.initials: A
authors.lastname: Ertan
authors.affiliation: Digestive Health Physicians, Cheektowaga, New York, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Camara
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Evan S
authors.initials: ES
authors.lastname: Dellon
authors.affiliation: Stanford University School of Medicine, Palo Alto, California, USA.
authors.forename: George
authors.initials: G
authors.lastname: Triadafilopoulos
authors.affiliation: Columbia University School of Medicine, New York, New York, USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Lightdale
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Madanick
authors.affiliation: Atlanta Gastroenterology Associates, Atlanta, Georgia, USA.
authors.forename: William D
authors.initials: WD
authors.lastname: Lyday
authors.affiliation: UCLA School of Medicine, Los Angeles, California, USA.
authors.forename: Raman V
authors.initials: RV
authors.lastname: Muthusamy
authors.affiliation: Gastrointestinal Associates, Knoxville, Tennessee, USA.
authors.forename: Bergein F
authors.initials: BF
authors.lastname: Overholt
authors.affiliation: Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Shaheen
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data; D001471:Barrett Esophagus / Q000208:ethnology* / Q000473:pathology / Q000601:surgery*; D017115:Catheter Ablation / Q000009:adverse effects; D004939:Esophageal Perforation / Q000208:ethnology / Q000209:etiology; D004940:Esophageal Stenosis / Q000208:ethnology / Q000209:etiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000208:ethnology / Q000209:etiology; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007198:Indians, North American / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D044382:Population Groups / Q000706:statistics & numerical data*; D019106:Postoperative Hemorrhage / Q000208:ethnology / Q000209:etiology; D011230:Precancerous Conditions / Q000208:ethnology* / Q000473:pathology / Q000601:surgery*; D012042:Registries; D012737:Sex Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
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