title: Role of Cellular Magnesium in Human Diseases.
abstract: Magnesium is required for many of the major organs to function and plays a crucial role in human and mammalian physiology. Magnesium is essential for the structure of bones and teeth, acts as a cofactor for more than 300 enzymes in the body, including binding to ATP for kinase reactions, and affects permeability of excitable membranes and neuromuscular transmission. Despite these essential roles, much is still unknown about magnesium physiology and homeostasis. Currently, nutritionists believe that the general population intakes insufficient magnesium daily through the diet. The effects of magnesium deficiency are, for the most part undetected, and simple, widespread assessments of magnesium intake remain unavailable for humans. Many of the patients admitted to hospitals or medical care facilities are unaware of their low magnesium levels. Moreover, because magnesium is predominantly an intracellular cation (>99%), serum magnesium levels remain a poor predictor of tissue magnesium content and availability. This review will discuss the effects of magnesium deficiency in various pathologies affecting the human population. The underlying causes for magnesium depletion in major physiological systems will be examined along with the involved signaling pathways and the main roles of magnesium homeostasis. Where possible (e.g. alcoholism), the implications of administering supplemental magnesium will be discussed. Ultimately, this review will advocate for the necessity of identifying easy and reproducible methods to assess serum and cellular magnesium levels and to identify magnesium deficiency in order to alleviate related pathological conditions.
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, USA.
authors.forename: Samantha
authors.initials: S
authors.lastname: Long
authors.affiliation: Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, USA.
authors.forename: Andrea Mp
authors.initials: AM
authors.lastname: Romani
keywords: Alcoholism; Bones; Cardiovascular system; Diabetes; Endocrine system; Magnesium homeostasis; Renal system; Reproductive biology
references.citation: Med Hypotheses. 2006;67(2):362-70
references.pmid: 16542786
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2894-9
references.pmid: 14976260
references.citation: Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S17-23
references.pmid: 15885623
references.citation: Br J Pharmacol. 1982 Dec;77(4):649-59
references.pmid: 7150872
references.citation: J R Soc Med. 1995 Aug;88(8):441-5
references.pmid: 7562826
references.citation: Calcif Tissue Int. 2003 Jan;72(1):32-41
references.pmid: 12370796
references.citation: Magnes Res. 2010 Jun;23(2):73-80
references.pmid: 20513641
references.citation: Neuropathology. 2006 Apr;26(2):115-28
references.pmid: 16708544
references.citation: J Aerosol Med. 2001 Fall;14(3):301-7
references.pmid: 11693841
references.citation: PLoS One. 2013;8(3):e57720
references.pmid: 23520480
references.citation: Arch Dis Child. 2005 Jan;90(1):74-7
references.pmid: 15613519
references.citation: J Nutr. 1985 Dec;115(12):1656-62
references.pmid: 4067656
references.citation: J Nutr. 1980 May;110(5):851-8
references.pmid: 6445415
references.citation: Int J Clin Exp Med. 2014 Jan 15;7(1):1-21
references.pmid: 24482684
references.citation: Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2046-55
references.pmid: 20935146
references.citation: PLoS One. 2013 Aug 15;8(8):e71096
references.pmid: 23976986
references.citation: J Res Med Sci. 2012 Oct;17(10):938-41
references.pmid: 23825993
references.citation: Lab Invest. 1975 Jul;33(1):80-7
references.pmid: 49455
references.citation: Chest. 2005 Jul;128(1):337-44
references.pmid: 16002955
references.citation: J Nutr. 1995 May;125(5):1205-10
references.pmid: 7738680
references.citation: Cell. 2003 Jul 25;114(2):191-200
references.pmid: 12887921
references.citation: J Nutr. 1984 Aug;114(8):1479-83
references.pmid: 6747730
references.citation: Subst Abuse Treat Prev Policy. 2008 Jan 25;3:1
references.pmid: 18218147
references.citation: Biochim Biophys Acta. 2013 Nov;1828(11):2778-92
references.pmid: 23954807
references.citation: Biol Trace Elem Res. 2010 Feb;133(2):136-43
references.pmid: 19488681
references.citation: Br J Anaesth. 2013 Feb;110(2):183-90
references.pmid: 23234642
references.citation: Nutr Rev. 2012 Mar;70(3):153-64
references.pmid: 22364157
references.citation: Nutrients. 2013 Jul 31;5(8):3022-33
references.pmid: 23912329
references.citation: Aust N Z J Psychiatry. 2009 Jan;43(1):45-52
references.pmid: 19085527
references.citation: Ann Emerg Med. 2000 Sep;36(3):181-90
references.pmid: 10969218
references.citation: Magnes Res. 2009 Sep;22(3):158S-162S
references.pmid: 19780402
references.citation: Nefrologia. 2013;33(3):389-99
references.pmid: 23640095
references.citation: Biol Trace Elem Res. 2003 Aug;94(2):105-12
references.pmid: 12958401
references.citation: Circulation. 2013 Jan 1;127(1):33-8
references.pmid: 23172839
references.citation: J Nutr Sci Vitaminol (Tokyo). 2013;59(6):560-3
references.pmid: 24477254
references.citation: Neuropharmacology. 2004 Dec;47(8):1189-97
references.pmid: 15567428
references.citation: Niger J Clin Pract. 2013 Oct-Dec;16(4):448-53
references.pmid: 23974737
references.citation: Asia Pac Allergy. 2012 Jan;2(1):76-85
references.pmid: 22348210
references.citation: J Int Med Res. 2007 Sep-Oct;35(5):692-5
references.pmid: 17944055
references.citation: Indian J Endocrinol Metab. 2012 Nov;16(6):1000-3
references.pmid: 23226651
references.citation: J Nat Sci Biol Med. 2013 Jan;4(1):113-6
references.pmid: 23633845
references.citation: Respir Med. 2013 Mar;107(3):321-30
references.pmid: 23290189
references.citation: Biol Trace Elem Res. 2010 May;134(2):119-29
references.pmid: 19629403
references.citation: Magnes Res. 2008 Dec;21(4):197-204
references.pmid: 19271417
references.citation: Science. 2013 Jul 12;341(6142):186-91
references.pmid: 23846901
references.citation: J Immunol. 2012 Jun 15;188(12):6338-46
references.pmid: 22611240
references.citation: J Physiol. 1954 May 28;124(2):370-84
references.pmid: 13175138
references.citation: Br J Exp Pathol. 1963 Apr;44:151-5
references.pmid: 13968527
references.citation: Int Urol Nephrol. 2008;40(4):1075-82
references.pmid: 18568412
references.citation: Int J Clin Exp Med. 2013 Oct 25;6(10):861-79
references.pmid: 24260592