title: Cancer-related fatigue: scientific progress has been made in 40 years
abstract: Cancer-related fatigue (CRF) is a distressing, persistent symptom that is experienced by survivors during and after treatment. Unsurprisingly, many early CRF studies were conducted by nurses. These studies included a look at patients receiving localized radiation treatment (Haylock & Hart, 1979); an exploration of fatigue as a conceptual approach to a clinical problem (Aistars, 1987); the development of a nursing theory focused on fatigue mechanisms (Piper, Lindsey, & Dodd, 1987); an examination of fatigue mechanisms (St Pierre, Kasper, & Lindsey, 1992), as well as of fatigue in advanced cancer (Bruera & MacDonald, 1988) and in non-small cell lung cancer (Sarna, 1993); and a description of fatigue and potential nursing interventions (Nail & King, 1987). Winningham et al. (1994) wrote a state-of-the-science article about fatigue in the cancer experience for the Oncology Nursing Forum, and Mock et al. (1997) was one of the first to conduct an exercise study regarding the effects of exercise on fatigue, physical functioning, and emotional distress during radiation therapy for breast cancer. Nurse scholars from the 1970s-2000s were pivotal in advancing the science of fatigue in various cancers and have provided a scientific foundation for those four decades.  .
authors.affiliation: School of Nursing, University of North Carolina, Chapel Hill, NC.
authors.forename: Ashley
authors.initials: A
authors.lastname: Leak Bryant
authors.affiliation: College of Nursing, University of Utah in Salt Lake City.
authors.forename: AnnMarie Lee
authors.identifier: 0000-0002-1756-4262
authors.initials: AL
authors.lastname: Walton
authors.affiliation: UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC.
authors.forename: Brett
authors.initials: B
authors.lastname: Phillips
mesh_terms: D004032:Diet; D015444:Exercise; D005221:Fatigue / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D009369:Neoplasms / Q000150:complications*
keywords: Putting Evidence Into Practice; cancer-related fatigue; exercise; nutrition
references.citation: Oncol Nurs Forum. 1987 Nov-Dec;14(6):25-30
references.pmid: 3320982
references.citation: CA Cancer J Clin. 2012 Jul-Aug;62(4):243-74
references.pmid: 22539238
references.citation: Arch Phys Med Rehabil. 2013 Feb;94(2):221-30
references.pmid: 23017985
references.citation: Recent Results Cancer Res. 2011;186:367-87
references.pmid: 21113773
references.citation: Cochrane Database Syst Rev. 2012 Aug 15;(8):CD008465
references.pmid: 22895974
references.citation: Am J Phys Med Rehabil. 2014 Aug;93(8):675-86
references.pmid: 24743466
references.citation: J Sci Med Sport. 2013 Mar;16(2):99-104
references.pmid: 22749527
references.citation: Oncol Nurs Forum. 1997 Jul;24(6):991-1000
references.pmid: 9243585
references.citation: CA Cancer J Clin. 2006 Nov-Dec;56(6):323-53
references.pmid: 17135691
references.citation: CA Cancer J Clin. 2009 Nov-Dec;59(6):391-410
references.pmid: 19897841
references.citation: Semin Oncol Nurs. 1987 Nov;3(4):257-62
references.pmid: 3423447
references.citation: Circulation. 1996 Aug 15;94(4):857-62
references.pmid: 8772712
references.citation: Cancer Nurs. 1979 Dec;2(6):461-7
references.pmid: 259440
references.citation: Am J Nurs. 1988 Jan;88(1):99-100
references.pmid: 3337154
references.citation: Oncol Nurs Forum. 1992 Apr;19(3):419-25
references.pmid: 1594464
references.citation: Circulation. 2006 Jul 4;114(1):82-96
references.pmid: 16785338
references.citation: Cancer Pract. 2002 Mar-Apr;10(2):66-74
references.pmid: 11903271
references.citation: Oncol Nurs Forum. 1994 Jan-Feb;21(1):23-36
references.pmid: 8139999
references.citation: Clin J Oncol Nurs. 2014;18 Suppl:38-58
references.pmid: 25427608
references.citation: J Clin Oncol. 2007 Jun 10;25(17):2345-51
references.pmid: 17557947
references.citation: J Adv Nurs. 1993 May;18(5):714-24
references.pmid: 8390495
references.citation: Oncol Nurs Forum. 1987 Nov-Dec;14(6):17-23
references.pmid: 3320981
references.citation: Oncol Nurs Forum. 1998 Jan-Feb;25(1):107-13
references.pmid: 9460778
references.citation: Med Sci Sports Exerc. 2010 Jul;42(7):1409-26
references.pmid: 20559064
references.citation: J Cancer Surviv. 2010 Jun;4(2):87-100
references.pmid: 20052559