title: Guiding and controlling percutaneous pancreas biopsies with contrast-enhanced ultrasound: target lesions are not localized on B-mode ultrasound.
abstract: The aim of the study described here was to prospectively investigate the clinical and practical value of percutaneous contrast-enhanced ultrasound (CEUS)-guided biopsy of pancreatic lesions that are not definitively localized by B-mode ultrasound (US). Fifty-three patients underwent CEUS-guided biopsy. The rate of satisfactory percutaneous biopsy was 96.23% (51/53) with a median number of puncture attempts per patient of 3.0, and the diagnostic accuracy in satisfactory sampling was 96.08% (49/51). The sensitivity of CEUS-guided biopsy in diagnosing malignancy was 90.48% (38/42). There was only one major complication in our study, a patient (1/51, 1.96%) with biliary peritonitis. For pancreatic lesions that are not definitively localized by B-mode US, puncture guided by CEUS could improve accuracy, lower the incidence of complications and avoid unnecessary biopsy.
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China. Electronic address: dyuxl301@aliyun.com.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Yu
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Liang
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Cheng
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Han
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Fang-Yi
authors.initials: FY
authors.lastname: Liu
authors.affiliation: Department of Interventional Ultrasound, General Hospital of Chinese People's Liberation Army, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D003287:Contrast Media; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D010743:Phospholipids; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D018084:Ultrasonography, Interventional / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride
keywords: B-mode ultrasound; Biopsy; Contrast-enhanced ultrasound; Core needle; Pancreas