title: Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data.
abstract: The skin tissue has been shown to behave like a nonlinear anisotropic material. This study was aimed to employ a constitutive fiber family equation to characterize the nonlinear anisotropic mechanical behavior of the rat and mice skin tissues in different anatomical locations, including the abdomen and back, using histostructural and uniaxial data. The rat and mice skin tissues were excised from the animals' body and then the histological analyses were performed on each skin type to determine the mean fiber orientation angle. Afterward, the preconditioned skin tissues were subjected to a series of quasi-static axial and circumferential loads until the incidence of failure. The crucial role of fiber orientation was explicitly added into a proposed strain energy density function. The material coefficients were determined using the constrained nonlinear optimization method based on the axial and circumferential extension data of the rat and mice samples at different anatomical locations. The material coefficients of the skins were given with R(2) ≥ 0.998. The results revealed a significant load-bearing capacity and stiffness of the rat abdomen compared to the rat back tissues. In addition, the mice abdomen showed a higher stiffness in the axial direction in comparison with circumferential one, while the mice back displayed its highest stiffness in the circumferential direction. The material coefficients of the rat and mice skin tissues were determined and well compared to the experimental data. The optimized fiber angles were also compared to the experimental histological data, and in all cases less than 11.85% differences were observed in both the skin tissues.
authors.affiliation: a School of Mechanical Engineering ; Iran University of Science and Technology ; Tehran , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Karimi
authors.forename: Seyyed Mohammadali
authors.initials: SM
authors.lastname: Rahmati
authors.forename: Mahdi
authors.initials: M
authors.lastname: Navidbakhsh
mesh_terms: D000818:Animals; D016880:Anisotropy; D008297:Male; D055595:Mechanical Phenomena; D051379:Mice; D008954:Models, Biological; D051381:Rats; D012867:Skin / Q000737:chemistry* / Q000648:ultrastructure*
keywords: anatomical locations; histological structure of skin tissue; skin tissues mechanics; strain-energy density function; uniaxial extension
references.citation: J Biomech. 2006;39(9):1603-10
references.pmid: 15990103
references.citation: J Biomech. 1979;12(6):423-36
references.pmid: 457696
references.citation: J Biomech. 2009 Mar 11;42(4):524-30
references.pmid: 19159887
references.citation: Comput Biol Med. 1998 Jul;28(4):377-92
references.pmid: 9805198
references.citation: Comput Methods Biomech Biomed Engin. 2015;18(16):1768-74
references.pmid: 25266627
references.citation: Australas Phys Eng Sci Med. 2014 Dec;37(4):645-54
references.pmid: 25151140
references.citation: J Biomech. 2001 Oct;34(10):1279-89
references.pmid: 11522307
references.citation: Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):2550-4
references.pmid: 23623067
references.citation: Comput Methods Biomech Biomed Engin. 2014 May;17(7):695-703
references.pmid: 22920461
references.citation: Dermatologica. 1957 Aug;115(2):106-11
references.pmid: 13473397
references.citation: Ann Biomed Eng. 2007 Jan;35(1):19-29
references.pmid: 17066325
references.citation: Skin Res Technol. 2000 Nov;6(4):214-221
references.pmid: 11428960
references.citation: J R Soc Interface. 2006 Feb 22;3(6):15-35
references.pmid: 16849214
references.citation: Biomech Model Mechanobiol. 2008 Aug;7(4):323-34
references.pmid: 17701064
references.citation: Br J Plast Surg. 1978 Jan;31(1):3-8
references.pmid: 342028
references.citation: Perfusion. 2014 Mar;29(2):178-83
references.pmid: 23999817
references.citation: Comput Methods Biomech Biomed Engin. 2015;18(13):1418-26
references.pmid: 24773299
references.citation: J R Soc Interface. 2012 Jun 7;9(71):1275-86
references.pmid: 22171063
references.citation: Biomaterials. 2009 Mar;30(8):1587-95
references.pmid: 19108884
references.citation: Acta Biomater. 2013 Apr;9(4):5913-25
references.pmid: 23261928
references.citation: J Biomech. 2007;40(11):2559-63
references.pmid: 17207488
references.citation: Comput Methods Biomech Biomed Engin. 2014;17 Suppl 1:26-7
references.pmid: 25074147
references.citation: Med Biol Eng Comput. 2014 Jul;52(7):589-99
references.pmid: 24888756
references.citation: Tissue Cell. 2015 Apr;47(2):152-8
references.pmid: 25758947
references.citation: Biomed Tech (Berl). 2014 Oct;59(5):439-46
references.pmid: 24706422
references.citation: J Synchrotron Radiat. 2005 Nov;12(Pt 6):727-33
references.pmid: 16239740
references.citation: Skin Res Technol. 2015 May;21(2):149-57
references.pmid: 25078795
references.citation: J Biomech. 2004 Jul;37(7):989-1000
references.pmid: 15165869
references.citation: Burns. 2004 Mar;30(2):109-14
references.pmid: 15019116
references.citation: J Theor Biol. 2006 Jan 21;238(2):290-302
references.pmid: 16043190
references.citation: J Mech Behav Biomed Mater. 2013 Feb;18:240-52
references.pmid: 23290820
references.citation: J R Soc Interface. 2011 Mar 6;8(56):435-50
references.pmid: 20659928
references.citation: J Biomech. 1976;9(10):649-57
references.pmid: 965417
references.citation: Comput Methods Biomech Biomed Engin. 2008 Oct;11(5):539-51
references.pmid: 19230148
references.citation: Med Eng Phys. 2008 Jun;30(5):599-606
references.pmid: 17869160
references.citation: Mater Sci Eng C Mater Biol Appl. 2014 Jun 1;39:253-8
references.pmid: 24863223
references.citation: J Invest Dermatol. 2011 Oct;131(10):2069-78
references.pmid: 21697889