title: [Molecular pathology of soft tissue tumors: Contribution to diagnosis and therapy prediction].
abstract: Soft tissue tumors are often challenging for pathologists on the basis of morphology alone; therefore, tumor-specific chromosomal aberrations, such as translocations and fusions, amplifications or deletions can be diagnostically useful. Fluorescence in situ hybridization is widely used for the detection of most aberrations in routine diagnostics. Furthermore, reverse transcriptase PCR, sequencing and specific immunohistochemical assays are also applied. Next generation sequencing has already contributed to the identification of hitherto unknown aberrations. Molecular pathology is mainly used in sarcomas to discriminate between different tumor entities. In terms of personalized therapy and targeted treatment, molecular pathology can be utilized to detect predictive markers.
authors.affiliation: Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Schmitz
authors.forename: H-U
authors.initials: HU
authors.lastname: Schildhaus
mesh_terms: D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004252:DNA Mutational Analysis; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D025202:Molecular Diagnostic Techniques; D008969:Molecular Sequence Data; D057285:Precision Medicine; D011379:Prognosis; D012509:Sarcoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology* / Q000628:therapy
chemical_list: D005819:Genetic Markers
references.citation: Am J Clin Pathol. 2011 Jun;135(6):839-44
references.pmid: 21571956
references.citation: Ann Oncol. 2010 Oct;21 Suppl 7:vii265-9
references.pmid: 20943625
references.citation: Sarcoma. 2012;2012:714986
references.pmid: 22550424
references.citation: Biotechniques. 2005 Jul;39(1):75-85
references.pmid: 16060372
references.citation: Biologics. 2007 Dec;1(4):347-53
references.pmid: 19707305
references.citation: Genes Chromosomes Cancer. 2010 Dec;49(12):1114-24
references.pmid: 20815032
references.citation: Lab Invest. 2011 Oct;91(10 ):1427-33
references.pmid: 21826056
references.citation: J Pathol. 2008 Oct;216(2):176-82
references.pmid: 18686281
references.citation: Mod Pathol. 2006 Jan;19(1):1-8
references.pmid: 16258512
references.citation: Genet Res Int. 2011;2011:497148
references.pmid: 22567356
references.citation: Am J Surg Pathol. 2010 Feb;34(2):216-22
references.pmid: 20087159
references.citation: PLoS One. 2015 Apr 06;10(4):e0120079
references.pmid: 25844809
references.citation: Histopathology. 2014 Jan;64(1):26-37
references.pmid: 24215322
references.citation: J Clin Oncol. 2002 Jun 1;20(11):2672-9
references.pmid: 12039929
references.citation: Nat Genet. 2013 Feb;45(2):180-5
references.pmid: 23313952
references.citation: Mod Pathol. 2012 Dec;25(12):1551-8
references.pmid: 22766794
references.citation: Cancer Discov. 2014 Aug;4(8):889-95
references.pmid: 24875859
references.citation: Clin Cancer Res. 2008 Jul 15;14(14):4550-5
references.pmid: 18628470
references.citation: Hum Pathol. 2012 May;43(5):764-8
references.pmid: 22154050
references.citation: Histopathology. 2014 Jan;64(1):2-11
references.pmid: 24164390
references.citation: BMC Clin Pathol. 2014 Jul 28;14:36
references.pmid: 25126005
references.citation: Mod Pathol. 2012 Jan;25(1):75-85
references.pmid: 21909081
references.citation: BMC Cancer. 2014 Jan 10;14 :13
references.pmid: 24410877
references.citation: Neuro Oncol. 2008 Dec;10 (6):946-57
references.pmid: 18650488
references.citation: Genes Chromosomes Cancer. 2011 Aug;50(8):644-53
references.pmid: 21584898
references.citation: Genes Chromosomes Cancer. 2015 Feb;54(2):63-71
references.pmid: 25231231
references.citation: Hum Pathol. 2014 Mar;45(3):573-82
references.pmid: 24444465
references.citation: Histopathology. 2013 Jan;62(2):294-304
references.pmid: 23020601
references.citation: Am J Surg Pathol. 2013 Nov;37(11):1648-59
references.pmid: 24061512
references.citation: Hum Pathol. 2011 Feb;42(2):176-84
references.pmid: 21111450
references.citation: Virchows Arch. 2012 Jun;460(6):621-8
references.pmid: 22569967
references.citation: Hum Pathol. 2011 Nov;42(11):1667-75
references.pmid: 21531005
references.citation: Br J Cancer. 2000 Apr;82(7):1271-5
references.pmid: 10755400
references.citation: Histopathology. 2012 Jul;61(1):59-68
references.pmid: 22394371
references.citation: Diagn Mol Pathol. 2006 Jun;15(2):83-9
references.pmid: 16778588