title: Aerosolized amphotericin B lipid complex and invasive pulmonary aspergillosis: a case report.
abstract: Invasive pulmonary aspergillosis (IPA) is an emerging life-threatening infection in immuno-compromised patients. The incidence of IPA following kidney transplantation is low (between 0.7 and 4%), yet mortality remains unacceptably high (75-80%). A first line therapy with voriconazole or lipid formulations of amphotericin B is often limited by co-morbidities, adverse effects and drug interactions. The case within this publication is the first described report of IPA in a renal transplant recipient responding to aerosolized amphotericin B lipid complex.
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Diana
authors.initials: D
authors.lastname: Canetti
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Cazzadori
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Adami
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lifrieri
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Cristino
authors.affiliation: Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Integrata di Verona, Italy; Nephrology and Dialysis Unit, Ospedale Pierantoni-Morgagni, Forli, Italy.
authors.forename: Ercole
authors.initials: E
authors.lastname: Concia
mesh_terms: D000336:Aerosols; D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy* / Q000401:mortality; D016030:Kidney Transplantation; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B