title: The role of omega-3 fatty acids in acute pancreatitis: a meta-analysis of randomized controlled trials.
abstract: To determine whether treatment with omega-3 fatty acids (ω-3 FA) provides benefits to patients with acute pancreatitis (AP). The Cochrane Library, PubMed, Embase, Web of Science, and Chinese Biomedical Literature Database were searched. Data analysis was performed using Revman 5.2 software. A total of eight randomized controlled trials (RCTs) were included. Overall, ω-3 FA treatment resulted in a significantly reduced risk of mortality (RR 0.35; 95% CI 0.16 to 0.75, p < 0.05), infectious complications (RR 0.54; 95% CI 0.34 to 0.85, p < 0.05) and length of hospital stay (MD -6.50; 95% CI -9.54 to -3.46, p < 0.05), but not length of ICU stay (MD -1.98; 95% CI -6.92 to 2.96, p > 0.05). In subgroup analysis, only patients who received ω-3 FA parenterally had some statistically significant benefits in terms of mortality (risk ratio (RR) 0.37; 95% confidence interval (CI) 0.16 to 0.86, p < 0.05), infectious complications (RR 0.5; 95% CI 0.28 to 0.9, p < 0.05) and length of hospital stay (mean difference (MD) -8.13; 95% CI -10.39 to -5.87, p < 0.001). The administration of ω-3 FA may be beneficial for decreasing mortality, infectious complications, and length of hospital stay in AP, especially when used parenterally. Large and rigorously designed RCTs are required to elucidate the efficacy of parenteral or enteral ω-3 FA treatment in AP.
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510515, China. lqiuchenggd@163.com.|Department of General Surgery, Jinling Hospital, Clinical College of Southern Medical University, Nanjing 210002, China. lqiuchenggd@163.com.
authors.forename: Qiu Cheng
authors.initials: QC
authors.lastname: Lei
authors.affiliation: Graduate School, Southern Medical University, Guangzhou 510515, China. MG1335118@smail.nju.edu.cn.|Department of General Surgery, Jinling Hospital, Clinical College of Southern Medical University, Nanjing 210002, China. MG1335118@smail.nju.edu.cn.|Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. MG1335118@smail.nju.edu.cn.
authors.forename: Xin Ying
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Surgery, Prince of Wales Hospital, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong 999077, China. xiaxianf@gmail.com.
authors.forename: Xian Feng
authors.initials: XF
authors.lastname: Xia
authors.affiliation: Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical College, Dongguan 523808, China. zhenghzgd@163.com.
authors.forename: Hua Zhen
authors.initials: HZ
authors.lastname: Zheng
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. ahbijingcheng@163.com.
authors.forename: Jing Cheng
authors.initials: JC
authors.lastname: Bi
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. easyhard666@163.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.affiliation: Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. liningnju@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000208:Acute Disease; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D010195:Pancreatitis / Q000628:therapy*; D010288:Parenteral Nutrition / Q000379:methods; D016032:Randomized Controlled Trials as Topic
chemical_list: D015525:Fatty Acids, Omega-3
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