title: Cylindrical diffuser axial detection profile is dependent on fiber design.
abstract: The axial emission and detection profiles of 1- and 2-cm cylindrical diffusing fibers based on concentration gradients of scatterers were measured. Based on these measurements, we describe a method for determination of the scatterer concentration gradient within the diffusers. Using a Monte Carlo model incorporating these concentrations, detection was simulated and found to agree with measurements. The measured and simulated detection profiles for these diffusers were found to be drastically different from those previously measured in an alternative diffuser design incorporating an end reflector. When using cylindrical diffusers as detection fibers, it is, therefore, important to understand the design of the fiber and characterize the detection behavior.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Baran
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D004058:Diffusion; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007909:Lenses; D008027:Light; D008029:Lighting / Q000295:instrumentation*; D008962:Models, Theoretical; D055100:Optical Fibers; D010778:Photochemotherapy / Q000295:instrumentation*; D012031:Refractometry / Q000295:instrumentation*; D012542:Scattering, Radiation
references.citation: Phys Med Biol. 2008 May 7;53(9):R61-109
references.pmid: 18401068
references.citation: Lasers Surg Med. 2004;34(4):348-51
references.pmid: 15083496
references.citation: Phys Med Biol. 1996 Jun;41(6):951-61
references.pmid: 8794477
references.citation: J Photochem Photobiol B. 2005 Jun 1;79(3):231-41
references.pmid: 15896650
references.citation: Clin Cancer Res. 2008 Aug 1;14(15):4869-76
references.pmid: 18676760
references.citation: CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81
references.pmid: 21617154
references.citation: J Biomed Opt. 2011 Aug;16(8):085003
references.pmid: 21895311
references.citation: Phys Med Biol. 2012 Oct 7;57(19):6025-46
references.pmid: 22968172
references.citation: Lasers Surg Med. 2013 Oct;45(8):542-50
references.pmid: 24037853
references.citation: J Biomed Opt. 2013 Oct;18(10):107007
references.pmid: 24150093