title: Towards an asymmetric organocatalytic α-cyanation of β-ketoesters.
abstract: This communication describes the first proof of concept for an asymmetric α-cyanation of β-ketoesters using a hypervalent iodine-based electrophilic cyanide-transfer reagent. A series of different organocatalysts has been investigated and it was found that the use of naturally occurring Cinchona alkaloids allows obtaining the target products in good yields and with moderate enantioselectivities up to er = 76:24 under operationally simple conditions.
authors.affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
authors.forename: Raghunath
authors.initials: R
authors.lastname: Chowdhury
authors.affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schörgenhumer
authors.affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
authors.forename: Johanna
authors.initials: J
authors.lastname: Novacek
authors.affiliation: Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
authors.forename: Mario
authors.initials: M
authors.lastname: Waser
keywords: Cinchona alkaloids; Hypervalent iodine; Organocatalysis; Phase-transfer catalysis
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