title: Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers.
abstract: OBJECTIVE
  Post-radiation skin damage is the result of alterations produced in the irradiated zone. There are different studies aimed at verifying the effectiveness of several kinds of molecules in the treatment of radiation-induced skin damage. The purpose of this study is to test a mixture with a formulation containing several natural active ingredients on actinic ulcers in patients receiving radiation therapies.
  
  
  METHODS
  The authors recruited 13 patients, and randomly divided them into a test group (T1) and a control group (T2). The patients in both groups were undergoing radiotherapy. The T1 group was treated with a mixture called ozolipoile, whereas the T2 group was administered hyaluronic acid gel followed by non-ablative laser therapy. We evaluated the obtained results, the time of clinical healing, the reduction of pain, and each side effect, comparing all data between the T1 and T2 groups.
  
  
  RESULTS
  The average Visual Analog Scale results showed decrease in pain in both groups; however, while the T1 group showed a significant decrease in the values, the T2 group reported a more gradual reduction in the values, without ever reaching the minimum values obtained with the treatment with ozolipoile.
  
  
  CONCLUSIONS
  Treatment of actinic ulcers with ozolipoile mixture leads to faster control of pain and to better healing of small-size ulcers.
authors.affiliation: Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Inchingolo
authors.affiliation: Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Tarullo
authors.affiliation: Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Cagiano
authors.affiliation: Private Practice, Dental Clinic, Bari, Italy.
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Resta
authors.affiliation: Private Practice, Dental Clinic, Bari, Italy.
authors.forename: Gianna
authors.initials: G
authors.lastname: Dipalma
authors.affiliation: Private Practice, Dental Clinic, Bari, Italy.
authors.forename: Angelo Michele
authors.initials: AM
authors.lastname: Inchingolo
authors.affiliation: Private Practice, Dental Clinic, Bari, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Tarullo
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sensorial Organs, University of Bari "Aldo Moro", Bari, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Scacco
authors.affiliation: Maxillofacial Unit, Calabrodental Clinic, Crotone, Italy ; Healthcare Center, Marrelli Hospital, Crotone, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Marrelli
authors.affiliation: UOC of Radiotherapy and Nuclear Medicine IOV - IRCCS, University of Padova, Padova, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Corti
authors.affiliation: Biomedical Section, Tecnologica Research Institute, Crotone, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tatullo
keywords: actinic ulcers; ozonide; radiation-induced ulcers; skin wound; wound healing
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