title: Biodistribution and radiation dosimetry of (82)Rb at rest and during peak pharmacological stress in patients referred for myocardial perfusion imaging.
abstract: OBJECTIVE
  (82)Rb is an ultra-short-lived positron emitter used for myocardial blood flow quantification with PET imaging. The aim of this study was to quantify the biodistribution and radiation dosimetry in patients with coronary disease and in healthy normal volunteers.
  
  
  METHODS
  A total of 30 subjects, 26 patients with known or suspected coronary artery disease (CAD) and four healthy volunteers were injected with (82)Rb chloride at 10 MBq/kg followed by a 10-min dynamic PET scan. Chest scans at rest were acquired in all subjects, as well as one additional biodistribution scan of the head, neck, abdomen, pelvis or thighs. Chest scans under stress were acquired in 25 of the CAD patients. (82)Rb time-integrated activity coefficients were determined in 22 source organs using volume of interest analysis, including corrections for partial-volume losses. The mean time-integrated activity coefficients were used to calculate the whole-body effective dose using tissue weighting factors from the International Commission on Radiological Protection (ICRP) Publications 60 and 103.
  
  
  RESULTS
  A total of 283 organ time-integrated activity coefficients were calculated, with a minimum of four values per source organ. The rest and stress mean effective dose was 0.8 mSv/GBq, according to the most recent ICRP definition. Using 10 MBq/kg for 3D PET imaging, the effective dose to a gender-averaged reference person (60 kg female and 73 kg male) is 1.1 mSv for a complete rest and stress perfusion study. For 2D PET using a typical injected activity of 1.1 to 2.2 GBq each for rest and stress, the effective dose for a complete study is 1.8 to 3.5 mSv.
  
  
  CONCLUSIONS
  The current effective dose estimate in CAD patients is four times lower than the values reported previously by the ICRP, and about 35% lower than previous in vivo studies in young healthy subjects.
authors.affiliation: Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
authors.forename: Chad R R N
authors.initials: CR
authors.lastname: Hunter
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hill
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Ziadi
authors.forename: Rob S B
authors.initials: RS
authors.lastname: Beanlands
authors.forename: Robert A
authors.initials: RA
authors.lastname: deKemp
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D049268:Positron-Emission Tomography; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes
references.citation: Ann ICRP. 2007;37(2-4):1-332
references.pmid: 18082557
references.citation: Health Phys. 2010 Dec;99(6):811-3
references.pmid: 21068600
references.citation: J Nucl Med. 2005 Jun;46(6):1023-7
references.pmid: 15937315
references.citation: Ann ICRP. 1991;21(1-3):1-201
references.pmid: 2053748
references.citation: Eur Heart J. 2013 Oct;34(38):2949-3003
references.pmid: 23996286
references.citation: EJNMMI Res. 2014 Mar 13;4(1):16
references.pmid: 24620906
references.citation: Ann ICRP. 1987;18(1-4):1-377
references.pmid: 3505163
references.citation: Ann ICRP. 1998;28(3):1-126
references.pmid: 10840563
references.citation: J Nucl Med. 2010 Oct;51(10):1592-9
references.pmid: 20847168
references.citation: Ann ICRP. 2009;39(2):1-164
references.pmid: 19897132
references.citation: Phys Med Biol. 2007 Feb 7;52(3):659-73
references.pmid: 17228112
references.citation: Eur J Nucl Med Mol Imaging. 2005 Jul;32(7):855-97
references.pmid: 15909197
references.citation: J Nucl Med. 2011 Mar;52(3):485-91
references.pmid: 21321275
references.citation: Circulation. 2003 Sep 16;108(11):1404-18
references.pmid: 12975245
references.citation: Health Phys. 1995 Aug;69(2):187-201
references.pmid: 7622365
references.citation: Eur J Nucl Med Mol Imaging. 2014 Jan;41(1):126-35
references.pmid: 23982454
references.citation: J Nucl Med. 2013 Aug;54(8):1485-507
references.pmid: 23781013
references.citation: J Nucl Med. 1982 Dec;23(12):1128-32
references.pmid: 6982966
references.citation: JACC Cardiovasc Imaging. 2014 Nov;7(11):1119-1127
references.pmid: 25306543
references.citation: J Nucl Med. 2006 Dec;47(12):1960-7
references.pmid: 17138738
references.citation: J Am Coll Cardiol. 2012 Oct 30;60(18):1828-37
references.pmid: 23040573