title: Longterm efficacy and safety of abatacept in patients with rheumatoid arthritis treated in routine clinical practice: effect of concomitant methotrexate after 24 weeks.
abstract: OBJECTIVE
  Our study aimed to evaluate the longterm efficacy and safety of abatacept (ABA), and to explore factors that increase its longterm efficacy in patients with rheumatoid arthritis (RA) treated in routine clinical practice.
  
  
  METHODS
  There were 231 participants with RA treated with ABA who were prospectively registered in a Japanese multicenter registry. They were followed up for at least 52 weeks.
  
  
  RESULTS
  Mean age of the patients was 64.3 years, mean disease duration was 12.1 years, mean 28-joint Disease Activity Score (DAS28)-C-reactive protein was 4.49, and 48.5% of patients were concomitantly treated with methotrexate (MTX). Overall retention rate of ABA was 77.1% at 52 weeks; 14.8% of patients discontinued because of inadequate response and 3.5% because of adverse events. The proportion of patients achieving DAS28-defined low disease activity (LDA) significantly increased from baseline to 52 weeks (7.3% to 43.8%, p < 0.01); 40.9% of patients who did not achieve LDA at 24 weeks had more than 1 categorical improvement in DAS28-defined disease activity at 52 weeks. Multivariate logistic regression revealed concomitant MTX use to be an independent predictor of the categorical improvement in DAS28-defined disease activity from 24 to 52 weeks (adjusted OR 3.124, p = 0.010).
  
  
  CONCLUSIONS
  In routine clinical practice, ABA demonstrated satisfactory clinical efficacy and safety in patients with established RA for 52 weeks. The clinical efficacy of ABA increased with time even after 24 weeks, and this was strongly influenced by concomitant MTX use. Our study provides valuable real-world findings on the longterm management of RA with ABA.
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine. nobunori@med.nagoya-u.ac.
authors.forename: Nobunori
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Kojima
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Daihei
authors.initials: D
authors.lastname: Kida
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirano
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujibayashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yabe
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Hideki
authors.initials: H
authors.lastname: Takagi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oguchi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyake
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kato
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kanayama
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Koji
authors.initials: K
authors.lastname: Funahashi
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Shuji
authors.initials: S
authors.lastname: Asai
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshioka
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Toki
authors.initials: T
authors.lastname: Takemoto
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Kenya
authors.initials: K
authors.lastname: Terabe
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Asai
authors.affiliation: From the Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, and Nagoya Medical Centre, and Nagoya Central Hospital, Nagoya; Department of Rheumatology, Toyohashi Municipal Hospital, Toyohashi; Department of Orthopedic Surgery, Konan Kosei Hospital, Konan; Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Tokyo; Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo; Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Ichinomiya; Kato Orthopedic Clinic, Okazaki; Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya; Department of Rheumatology, Nagano Red Cross Hospital, Nagano; Department of Orthopedic Surgery, Toyota Kosei Hospital, Toyota, Japan.N. Takahashi, MD, PhD; T. Kojima, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine; A. Kaneko, MD; D. Kida, MD, PhD; Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Centre; Y. Hirano, MD, PhD, Department of Rheumatology, Toyohashi Municipal Hospital; T. Fujibayashi, MD, PhD, Department of Orthopedic Surgery, Konan Kosei Hospital; Y. Yabe, MD, PhD, Department of Rheumatology, Tokyo Kosei Nenkin Hospital; H. Takagi, MD, PhD, Department of Orthopedic Surgery, Nagoya Central Hospital; T. Oguchi, MD, PhD, Department of Orthopedic Surgery, Anjo Kosei Hospital; H. Miyake, MD, PhD, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital; T. Kato, MD, PhD, Kato Orthopedic Clinic; T. Watanabe, MD, PhD, Department of Orthopedic Surgery, Kariya-Toyota General Hospital; M. Hayashi, MD, Department of Rheumatology, Nagano Red Cross Hospital; Y. Kanayama, MD, PhD, Department of Orthopedic Surgery, Toyota Kosei Hospital; K. Funahashi, MD, PhD; S. Asai, MD, PhD; Y. Yoshioka, MD, PhD; T. Takemoto, MD; K. Terabe, MD; N. Asai, MD; N. Ishiguro, MD, PhD, Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000069594:Abatacept / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D012042:Registries; D012074:Remission Induction; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D000069594:Abatacept; D008727:Methotrexate
keywords: ABATACEPT; LONGTERM EFFECT; METHOTREXATE; MULTICENTER STUDIES; RHEUMATOID ARTHRITIS