title: Dynamic knee joint function in children with juvenile idiopathic arthritis (JIA).
abstract: BACKGROUND
  Juvenile idiopathic arthritis (JIA) is a chronic illness with a high risk of developing long-term disability. Disease activity is currently being monitored and quantified by ACR core set. Here, joint inflammation is determined; however joint function is the crucial component for developing disability. The aim of this study was to quantify and compare dynamic joint function in healthy and arthritic knee joints and to evaluate response to improvement.
  
  
  METHODS
  A single center cohort study of consecutive children presenting to the rheumatology outpatient clinic was performed to measure dynamic knee joint function. Serial measures were performed if possible. Splint fixed electrogoniometers were used to measure dynamic knee joint function including ROM and flexion and extension torque.
  
  
  RESULTS
  A total of 54 children were tested including 44 with JIA, of whom eight had to be excluded for non-JIA-related knee problems. The study included 36 JIA patients of whom eight had strictly unilateral knee arthritis, and nine controls. Dynamic joint function ROM and torque depended on age and bodyweight, as demonstrated in healthy joints. ROM and torques were significant lower in arthritic compared to unaffected knee joints in children with unilateral arthritis and across the cohort. Importantly, extension torque was the most sensitive marker of impaired joint function. Follow up measurements detected responsiveness to change in disease activity.
  
  
  CONCLUSIONS
  Measuring dynamic joint function with electrogoniometers is feasible and objective. Active ROM and torque during flexion and extension of arthritic knee joints were significant lower compared to unaffected. In dynamic joint measurement extension torque is a sensitive marker for disease activity.
authors.affiliation: Rheumatology, General Pediatrics, Oncology and Hematology University Children's Hospital Tuebingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hansmann
authors.affiliation: Rheumatology, General Pediatrics, Oncology and Hematology University Children's Hospital Tuebingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany ; Rheumatology, Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta Canada.
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Benseler
authors.affiliation: Rheumatology, General Pediatrics, Oncology and Hematology University Children's Hospital Tuebingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany.
authors.forename: Jasmin B
authors.initials: JB
authors.lastname: Kuemmerle-Deschner
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000503:physiopathology*; D053587:Arthrometry, Articular / Q000379:methods; D001835:Body Weight / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D016059:Range of Motion, Articular / Q000502:physiology*; D012720:Severity of Illness Index; D019415:Torque; D055815:Young Adult
keywords: Electrogoniometry; Joint function; Juvenile idiopathic arthritis
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