title: Pharmacogenomics and herb-drug interactions: merge of future and tradition.
abstract: The worldwide using of herb products and the increasing potential herb-drug interaction issue has raised enthusiasm on discovering the underlying mechanisms. Previous review indicated that the interactions may be mediated by metabolism enzymes and transporters in pharmacokinetic pathways. On the other hand, an increasing number of studies found that genetic variations showed some influence on herb-drug interaction effects whereas these genetic factors did not draw much attention in history. We highlight that pharmacogenomics may involve the pharmacokinetic or pharmacodynamic pathways to affect herb-drug interaction. We are here to make an updated review focused on some common herb-drug interactions in association with genetic variations, with the aim to help safe use of herbal medicines in different individuals in the clinic.
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Mou-Ze
authors.identifier: 0000-0002-6201-8199
authors.initials: MZ
authors.lastname: Liu
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Yue-Li
authors.initials: YL
authors.lastname: Zhang
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Mei-Zi
authors.initials: MZ
authors.lastname: Zeng
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Fa-Zhong
authors.initials: FZ
authors.lastname: He
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Zhi-Ying
authors.initials: ZY
authors.lastname: Luo
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Jian-Quan
authors.initials: JQ
authors.lastname: Luo
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Jia-Gen
authors.initials: JG
authors.lastname: Wen
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Hong-Hao
authors.initials: HH
authors.lastname: Zhou
authors.affiliation: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China ; Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
references.citation: Curr Pharm Biotechnol. 2012 Jul;13(9):1718-30
references.pmid: 22039823
references.citation: Curr Drug Metab. 2012 Jun 1;13(5):640-51
references.pmid: 22292789
references.citation: J Ethnopharmacol. 2014 Jul 3;154(3):672-86
references.pmid: 24832110
references.citation: Fundam Clin Pharmacol. 2009 Jun;23(3):359-65
references.pmid: 19453758
references.citation: J Clin Pharmacol. 2005 Jun;45(6):690-4
references.pmid: 15901751
references.citation: Trends Pharmacol Sci. 2013 Feb;34(2):85-6
references.pmid: 23277336
references.citation: Toxicol Appl Pharmacol. 2014 Mar 1;275(2):163-75
references.pmid: 24380838
references.citation: Evid Based Complement Alternat Med. 2013;2013:179643
references.pmid: 23710212
references.citation: Clin Pharmacol Ther. 2004 Mar;75(3):191-7
references.pmid: 15001970
references.citation: Int Clin Psychopharmacol. 2012 Mar;27(2):121-4
references.pmid: 22113252
references.citation: N Engl J Med. 1993 Jan 28;328(4):246-52
references.pmid: 8418405
references.citation: Pharmacogenet Genomics. 2011 Feb;21(2):84-93
references.pmid: 21280267
references.citation: Br J Pharmacol. 2008 Apr;153(7):1579-86
references.pmid: 18204476
references.citation: Phytother Res. 2011 Aug;25(8):1141-7
references.pmid: 21287651
references.citation: Food Chem Toxicol. 2013 Sep;59:549-53
references.pmid: 23835282
references.citation: Pharmacogenetics. 2004 Dec;14 (12 ):841-50
references.pmid: 15608563
references.citation: Br J Pharmacol. 2008 Aug;154(8):1691-700
references.pmid: 18516070
references.citation: Br J Clin Pharmacol. 2009 Feb;67(2):255-61
references.pmid: 19173680
references.citation: Evid Based Complement Alternat Med. 2013;2013:327629
references.pmid: 23737827
references.citation: Eur J Clin Pharmacol. 2007 Apr;63(4):345-53
references.pmid: 17297618
references.citation: Clin Pharmacol Ther. 2005 Jul;78(1):25-33
references.pmid: 16003289
references.citation: Drug Metab Pharmacokinet. 2013;28(2):104-8
references.pmid: 22850760
references.citation: Expert Rev Mol Diagn. 2012 Nov;12(8):815-30
references.pmid: 23249200
references.citation: J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):98-100
references.pmid: 22323244
references.citation: Curr Drug Metab. 2012 Jun 1;13(5):615-23
references.pmid: 22475332
references.citation: J Ethnopharmacol. 2014;151(1):210-7
references.pmid: 24157377
references.citation: J Clin Pharmacol. 2011 May;51(5):751-60
references.pmid: 20974993
references.citation: Phytomedicine. 2010 Nov;17(13):1016-26
references.pmid: 20739164
references.citation: Pharmacogenomics J. 2012 Oct;12 (5):372-8
references.pmid: 21647174
references.citation: Clin Pharmacol Ther. 2004 Jan;75(1):89-100
references.pmid: 14749695
references.citation: Drug Metab Dispos. 2014 Mar;42(3):301-17
references.pmid: 24335390
references.citation: Clin Pharmacokinet. 2011 Sep;50(9):605-11
references.pmid: 21827215
references.citation: N Engl J Med. 2011 Mar 24;364(12):1144-53
references.pmid: 21428770
references.citation: Mol Nutr Food Res. 2008 Jul;52(7):799-809
references.pmid: 18618477
references.citation: Xenobiotica. 2006 Jan;36(1):95-102
references.pmid: 16507515
references.citation: Curr Opin Drug Discov Devel. 2010 Jan;13(1):50-65
references.pmid: 20047146
references.citation: Acta Pharmacol Sin. 2007 Oct;28(10 ):1685-92
references.pmid: 17883958
references.citation: Br J Clin Pharmacol. 2006 Aug;62(2):177-86
references.pmid: 16842392
references.citation: Clin Pharmacol Ther. 2008 Mar;83(3):471-6
references.pmid: 17851565
references.citation: J Ethnopharmacol. 2013 Apr 19;146(3):744-9
references.pmid: 23422332
references.citation: Eur J Clin Pharmacol. 2009 Jun;65(6):585-91
references.pmid: 19221727
references.citation: Complement Ther Med. 2013 Jun;21(3):260-71
references.pmid: 23642959
references.citation: J Clin Pharmacol. 2004 Jun;44(6):577-81
references.pmid: 15145964
references.citation: Eur J Clin Pharmacol. 2009 Apr;65(4):403-9
references.pmid: 19066872
references.citation: BMC Complement Altern Med. 2008 Apr 23;8:14
references.pmid: 18433476
references.citation: Xenobiotica. 2012 Jun;42(6):596-602
references.pmid: 22208477
references.citation: Clin Pharmacol Ther. 2007 May;81(5):669-78
references.pmid: 17392718
references.citation: Afr J Tradit Complement Altern Med. 2010;7(4):322-30
references.pmid: 21731164
references.citation: Clin Pharmacokinet. 2012 Feb 1;51(2):77-104
references.pmid: 22257149