title: MARK-AGE biomarkers of ageing.
abstract: Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.
authors.affiliation: Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany. Electronic address: alexander.buerkle@uni-konstanz.de.
authors.forename: Alexander
authors.initials: A
authors.lastname: Bürkle
authors.affiliation: Molecular Toxicology Group, Department of Biology, Box 628, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: María
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authors.lastname: Moreno-Villanueva
authors.affiliation: BioTeSys GmbH, 73728 Esslingen, Germany.
authors.forename: Jürgen
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authors.lastname: Bernhard
authors.affiliation: Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro, 28029 Madrid, Spain.
authors.forename: María
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authors.lastname: Blasco
authors.affiliation: DNage BV(1), Leiden, The Netherlands.
authors.forename: Gerben
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authors.lastname: Zondag
authors.affiliation: Department of Genetics, Erasmus University Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
authors.forename: Jan H J
authors.initials: JH
authors.lastname: Hoeijmakers
authors.affiliation: University of Namur, Research Unit on Cellular Biology, Rue de Bruxelles, 61, Namur B-5000, Belgium.
authors.forename: Olivier
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authors.lastname: Toussaint
authors.affiliation: Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020 Innsbruck, Austria.
authors.forename: Beatrix
authors.initials: B
authors.lastname: Grubeck-Loebenstein
authors.affiliation: Translational Research Center of Nutrition and Ageing, IRCCS-INRCA, Via Birarelli 8, 60121 Ancona, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Mocchegiani
authors.affiliation: Nestlé Institute of Health Sciences SA, Molecular Biomarkers, EPFL Innovation Park, 1015 Lausanne, Switzerland.
authors.forename: Sebastiano
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authors.lastname: Collino
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, Athens, Greece.
authors.forename: Efstathios S
authors.initials: ES
authors.lastname: Gonos
authors.affiliation: Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093 Warsaw, Poland.
authors.forename: Ewa
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authors.affiliation: Ana Aslan - National Institute of Gerontology and Geriatrics, Bucharest, Romania.
authors.forename: Daniela
authors.initials: D
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authors.affiliation: National Institute for Public Health and the Environment (RIVM), Centre for Prevention and Health Services Research, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
authors.forename: Martijn
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authors.affiliation: Straticell, Science Park Crealys, Rue Jean Sonet 10, 5032 Les Isnes, Belgium.
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authors.affiliation: Department of Engineering - BCE Protein Engineering, Gustav Wiedsvej 10, 8000 Aarhus, Denmark.
authors.forename: Peter
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authors.affiliation: Life and Health Sciences, Aston Research Centre for Healthy Ageing, Aston University, Birmingham, UK.
authors.forename: Helen R
authors.initials: HR
authors.lastname: Griffiths
authors.affiliation: Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
authors.affiliation: Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany; Department of Nutritional Toxicology, Friedrich Schiller University Jena, Dornburger Str. 24, 07743 Jena, Germany.
authors.forename: Tilman
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authors.lastname: Grune
authors.affiliation: Institute of Nutritional Medicine, University of Hohenheim, 70593 Stuttgart, Germany.
authors.forename: Nicolle
authors.initials: N
authors.lastname: Breusing
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital Halle, Ernst-Grube Str. 40, 06120 Halle (Saale), Germany.
authors.forename: Andreas
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authors.lastname: Simm
authors.affiliation: CIG-Interdepartmental Center "L.Galvani", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Franceschi
authors.affiliation: CIG-Interdepartmental Center "L.Galvani", Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy.
authors.forename: Miriam
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authors.lastname: Capri
authors.affiliation: Unilever Corporate Research, Sharnbrook, UK.
authors.forename: Duncan
authors.initials: D
authors.lastname: Talbot
authors.affiliation: Department of Cellular Biotechnologies and Hematology, Faculty of Pharmacy and Medicine, "Sapienza" University Rome, V.le Regina Elena 324, 00161 Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Caiafa
authors.affiliation: Sorbonne Universités, UPMC Univ Paris 06, UMR UPMC CNRS 8256, Biological adaptation and ageing - IBPS, INSERM U1164, F-75005 Paris, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Friguet
authors.affiliation: Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: P Eline
authors.initials: PE
authors.lastname: Slagboom
authors.affiliation: Medical School, University of Tampere, 33014 Tampere, Finland.
authors.forename: Antti
authors.initials: A
authors.lastname: Hervonen
authors.affiliation: Medical School, University of Tampere, 33014 Tampere, Finland.
authors.forename: Mikko
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authors.lastname: Hurme
authors.affiliation: Regenerative Medicine Group, Cranfield Health, Cranfield, UK.
authors.forename: Richard
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authors.lastname: Aspinall
mesh_terms: D000375:Aging / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D005062:European Union; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D015415:Biomarkers
keywords: Ageing biomarkers; Human studies; MARK-AGE