title: [Comparative study of the determination of the HER2 status in gastric cancer in the biopsy and intraoperative specimens].
abstract: OBJECTIVE
  To determine the HER2 status of gastric adenocarcinomas, by using biopsy and intraoperative specimens.
  
  
  METHODS
  Immunohistochemistry and in situ hybridization were used to examine the HER2 status of 346 gastric cancer biopsy and intraoperative specimens.
  
  
  RESULTS
  The study conducted on a large Russian sample of 346 patients showed a positive HER2 status in 10.7% of the examined specimens. Intestinal-type adenocarcinomas exhibited a positive HER2 status in 21.4% of the cases. Comparative analysis of the HER2 status in the biopsy and intraoperative specimens indicated that there were differences in the determination of the tumor HER2 status in less than 1% of the examined specimens. The remaining found differences (14.7%) failed to change the tumor HER2 status and to affect the choice of a treatment regimen.
  
  
  CONCLUSIONS
  The performed investigation has demonstrated that the tumor HER2 status determined in the biopsy specimen significantly reflects the molecular biological properties of gastric cancer and may be clinically used to determine indications for the use of targeted drugs.
authors.affiliation: Kafedra patologicheskoĭ anatomii GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii, Moskva.
authors.forename: L É
authors.initials: LÉ
authors.lastname: Zavalishina
authors.affiliation: Kafedra patologicheskoĭ anatomii GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii, Moskva.
authors.forename: Iu Iu
authors.initials: II
authors.lastname: Andreeva
authors.affiliation: GBU "Riazanskiĭ oblastnoĭ onkologicheskiĭ dispanser", Riazan'.
authors.forename: I Iu
authors.initials: II
authors.lastname: Vinogradov
authors.affiliation: Kafedra patologicheskoĭ anatomii GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii, Moskva; Fakul'tet fundamental'noĭ meditsiny FGBU VPO "Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova", Moskva, Rossiĭskaia Federatsiia.
authors.forename: N V
authors.initials: NV
authors.lastname: Danilova
authors.affiliation: Fakul'tet lechebnogo dela GBOU VPO "Rossiĭskiĭ natsional'nyĭ issledovatel'skiĭ meditsinskiĭ universitet im. N.I. Pirogova" Minzdrava Rossii, Moskva.
authors.forename: O A
authors.initials: OA
authors.lastname: Kuznetsova
authors.affiliation: Kafedra patologicheskoĭ anatomii GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia" Minzdrava Rossii, Moskva.
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human