title: How gene expression in fast-proliferating cells keeps pace.
abstract: The development of living organisms requires a precise coordination of all basic cellular processes, in space and time. Early embryogenesis of most species with externally deposited eggs starts with a series of extremely fast cleavage cycles. These divisions have a strong influence on gene expression as mitosis represses transcription and pre-mRNA processing. In this review, we will describe the distinct adaptations for efficient gene expression and discuss the emerging role of the multifunctional NineTeen Complex (NTC) in gene expression and genomic stability during fast proliferation.
authors.affiliation: Departamento de Ciências Biomédicas e Medicina, Regenerative Medicine Program, Universidade do Algarve, Campus de Gambelas, Faro, Portugal; Center for Biomedical Research, Universidade do Algarve, Campus de Gambelas, Faro, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
authors.forename: Rui G
authors.initials: RG
authors.lastname: Martinho
authors.forename: Leonardo G
authors.initials: LG
authors.lastname: Guilgur
authors.forename: Pedro
authors.initials: P
authors.lastname: Prudêncio
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000235:genetics / Q000502:physiology; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics; D017381:Spliceosomes / Q000235:genetics*
chemical_list: D012322:RNA Precursors
keywords: MBT; MZT; NTC/Prp19; drosophila; intronless genes; splicing; transcription