title: Saxagliptin is similar in glycaemic variability more effective in metabolic control than acarbose in aged type 2 diabetes inadequately controlled with metformin.
abstract: This study compared the effects on glycaemic variability and glucose control between saxagliptin and acarbose as add-on therapies for aged T2DM inadequately controlled with metformin alone. The results showed that compared with acarbose-metformin, saxagliptin-metformin was more effective in glucose control with similar glycaemic variability.
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Man-man
authors.initials: MM
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Yan-ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Shu
authors.affiliation: Department of Endocrinology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
authors.forename: Hong-yun
authors.initials: HY
authors.lastname: Lu
authors.affiliation: Department of Endocrinology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, China.
authors.forename: Yong-jun
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Ru-ying
authors.initials: RY
authors.lastname: Xie
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
authors.forename: Long-yi
authors.initials: LY
authors.lastname: Zeng
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China. Electronic address: mupanwei@mail.sysu.edu.cn.
authors.forename: Pan-wei
authors.initials: PW
authors.lastname: Mu
mesh_terms: D020909:Acarbose / Q000008:administration & dosage / Q000627:therapeutic use*; D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D048909:Diabetes Complications / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D020909:Acarbose; D000218:Adamantane; D001786:Blood Glucose; D004151:Dipeptides; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; C502994:saxagliptin
keywords: Acarbose; Glycaemic variability; Saxagliptin; Type 2 diabetes mellitus