title: Chemical Constituents and an Alternative Medicinal Veterinary Herbal Soap Made from Senna macranthera.
abstract: Upon undergoing biomonitoring, the most active dichloromethane extract retrieved from Senna macranthera roots led to the isolation of three main compounds: emodine, physione, and chrysophanol. In this sequence, these compounds revealed a potential antibacterial activity against Staphylococcus aureus strains isolated from animals with mastitis infections with minimum inhibitory concentration (MIC) values of 20, 90, and 90 μg mL(-1), respectively. Therefore, an herbal soap was also produced from this same active extract. This soap was tested in vitro using gloves contaminated by animals with bovine mastitis that had been discarded after use by milkers and showed similar results to previously tested compounds. These results indicate the potential of this plant as an alternative veterinary medicine for the production of antibacterial soaps that aimed at controlling bovine mastitis infections in small Brazilian farms.
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Flávia
authors.initials: F
authors.lastname: Inoue Andrade
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Gislaine Aparecida
authors.initials: GA
authors.lastname: Purgato
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Thalita
authors.initials: T
authors.lastname: de Faria Maia
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Raoni
authors.initials: R
authors.lastname: Pais Siqueira
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Sâmia
authors.initials: S
authors.lastname: Lima
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Gaspar
authors.identifier: 0000-0002-7515-0420
authors.initials: G
authors.lastname: Diaz
authors.affiliation: Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, 36570-000 Viçosa, MG, Brazil.
authors.forename: Marisa Alves Nogueira
authors.initials: MA
authors.lastname: Diaz
references.citation: Mem Inst Oswaldo Cruz. 2002 Oct;97(7):1027-31
references.pmid: 12471432
references.citation: J Agric Food Chem. 2001 Sep;49(9):4168-70
references.pmid: 11559104
references.citation: PLoS Pathog. 2009 May;5(5):e1000422
references.pmid: 19424490
references.citation: J Agric Food Chem. 2004 Oct 6;52(20):6096-100
references.pmid: 15453672
references.citation: J Antimicrob Chemother. 2007 Feb;59(2):301-4
references.pmid: 17142818
references.citation: Clin Microbiol Rev. 1999 Oct;12(4):564-82
references.pmid: 10515903
references.citation: Int J Dermatol. 2004 Jul;43 Suppl 1:3-8
references.pmid: 15271193
references.citation: J Med Microbiol. 2007 Apr;56(Pt 4):519-23
references.pmid: 17374894