title: Oxidative stress and immune system in vitiligo and thyroid diseases.
abstract: Vitiligo is an acquired dermatological disease frequently associated with autoimmune thyroid disorders. Several theories have been proposed so far to unravel the complex vitiligo pathogenesis. Currently, the autocytotoxic and the autoimmune theories are the most accredited hypothesis, since they are sustained by several important clinical and experimental evidences. A growing body of evidences shows that autoimmunity and oxidative stress strictly interact to finally determine melanocyte loss. In this scenario, associated thyroid autoimmunity might play an active and important role in triggering and maintaining the depigmentation process of vitiligo.
authors.affiliation: Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Ospedale Piero Palagi, Viale Michelangelo 41, 50125 Florence, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Colucci
authors.affiliation: Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Ospedale Piero Palagi, Viale Michelangelo 41, 50125 Florence, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Dragoni
authors.affiliation: Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Ospedale Piero Palagi, Viale Michelangelo 41, 50125 Florence, Italy.
authors.forename: Silvia
authors.identifier: 0000-0002-0681-7690
authors.initials: S
authors.lastname: Moretti
mesh_terms: D015551:Autoimmunity; D006801:Humans; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D013959:Thyroid Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D014820:Vitiligo / Q000276:immunology / Q000378:metabolism*
chemical_list: D017382:Reactive Oxygen Species
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