title: Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population.
abstract: BACKGROUND
  Neurodevelopmental effects of omega-3 fatty acids and mercury from fish consumption have been characterized in children. In contrast, neurobehavioral outcomes associated with fish are not well studied in adults.
  
  
  OBJECTIVE
  This study of avid seafood consumers on Long Island (NY, USA) sought to define associations between mercury, seafood consumption, omega-3 fatty acids and neurobehavioral outcomes.
  
  
  METHODS
  A computer-based test system was used to assess neurobehavioral function. Blood total Hg (Hg) and omega-3 index were measured in 199 adult avid seafood eaters, who also completed the neurobehavioral assessment and an extensive food and fish frequency and demographic questionnaire.
  
  
  RESULTS
  For most of the outcomes considered, neither Hg nor omega-3 index was associated with neurobehavioral outcomes after adjustment for key confounding variables. Fish consumption, however, was associated with decreased odds of both self-reported fatigue (OR 0.85; 95 % CI 0.72, 1.01) and a constellation of neurologic symptoms (OR 0.79; 95 % CI 0.66, 0.96).
  
  
  CONCLUSIONS
  Results from our study provide little evidence that omega-3 fatty acids or Hg is associated with cognitive function in adult avid seafood consumers. Larger studies are needed to confirm our finding of associations between fish consumption and decreased self-reported fatigue and neurologic impairment.
authors.affiliation: Program in Public Health, Department of Preventive Medicine, Stony Brook University, Stony Brook, NY, 11794, USA. caterina.vacchi-suzzi@stonybrookmedicine.edu.
authors.forename: Caterina
authors.initials: C
authors.lastname: Vacchi-Suzzi
authors.affiliation: School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Roxanne
authors.initials: R
authors.lastname: Karimi
authors.affiliation: School of Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Kruse
authors.affiliation: Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, 98195, USA.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Silbernagel
authors.affiliation: Trace Inorganics Department, Technologies for Industry and the Environment, RTI International, Research Triangle Park, NC, 27709, USA.
authors.forename: Keith E
authors.initials: KE
authors.lastname: Levine
authors.affiliation: Occupational and Environmental Health, University of Iowa, Iowa City, IA, 52242, USA.|Oregon Institute for Occupational Health Sciences, Oregon Health and Science University, Portland, OR, 97239, USA.
authors.forename: Diane S
authors.initials: DS
authors.lastname: Rohlman
authors.affiliation: Program in Public Health, Department of Preventive Medicine, Stony Brook University, Stony Brook, NY, 11794, USA.
authors.forename: Jaymie R
authors.initials: JR
authors.lastname: Meliker
mesh_terms: D000328:Adult; D000818:Animals; D003071:Cognition; D003863:Depression / Q000097:blood / Q000209:etiology; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D005399:Fishes; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008628:Mercury / Q000097:blood*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D009518:New York; D017747:Seafood / Q000032:analysis; D012643:Selenium / Q000097:blood; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D015525:Fatty Acids, Omega-3; D008628:Mercury; D012643:Selenium
keywords: Mercury; Methylmercury; Neurobehavioral test; Neurological test; Omega-3; n-3 fatty acids
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