title: Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.
abstract: Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-α-induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo.
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Ming-Zhi
authors.initials: MZ
authors.lastname: Zhao
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Nai-Peng
authors.initials: NP
authors.lastname: Cui
authors.affiliation: Central Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Lin
authors.affiliation: Central Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: An-Yi
authors.initials: AY
authors.lastname: Zhang
authors.affiliation: Central Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Liu
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Wei-Tao
authors.initials: WT
authors.lastname: Yan
authors.affiliation: Central Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Shi
authors.affiliation: Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.
authors.forename: Bao-Ping
authors.initials: BP
authors.lastname: Chen
keywords: Apoptosis; Breast cancer; EMT, epithelial–mesenchymal transition; FACS, fluorescence-activated cell sorting; FBS, fetal bovine serum; KLF4, Krüppel-like factor 4; Krüppel-like factor 4; Proliferation; SNK, Student–Newman–Keuls; TNF-α, tumor necrosis factor-α; Tumorigenicity; iPSC, induced pluripotent stem cell
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