title: The relationship between renal volume and histology in obese and nonobese kidney donors.
abstract: BACKGROUND
  Obesity and related kidney diseases have become a global epidemic problem. However, the underlying pathogenesis of obesity-related renal diseases has not been clearly understood. In this study, we explored the link between renal volume (RV) determined by computed tomography (CT) and renal histology together with functional parameters in an obese population.
  
  
  METHODS
  Eighty-two kidney donors who underwent CT for the measurement of kidney volume and zero-hour renal biopsy for renal histology were included in this cross-sectional study. Protein creatinine clearance and eGFR were evaluated in 24-h urine specimens as indicators of renal function.
  
  
  RESULTS
  Mean body mass index (BMI) was 28 ± 4.2 kg/m(2); 32.9% (n = 27) were obese. Mean RV was 196 ± 36 cm(3). RV was positively correlated with BMI, body surface area and creatinine clearance and negatively with HDL-cholesterol in the whole population. Renal function parameters of obese subjects were better, and their renal volumes were higher compared with the nonobese subjects. In obese subjects, corrected RV was positively correlated with glomerular filtration rate (r = 0.46, P = 0.01) and negatively with sclerotic glomeruli (r = -0.38, P = 0.04) and chronicity index (r = -0.43, P = 0.02). In adjusted ordinal logistic regression analysis, corrected RV was significantly associated with chronicity index (OR: 0.96; P = 0.01).
  
  
  CONCLUSIONS
  In obese cases, decreased RV determined by CT is associated with worse renal histology. In this population, kidney imaging techniques may provide important clues about renal survival.
authors.affiliation: Department of Nephrology, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.
authors.forename: Erhan
authors.initials: E
authors.lastname: Tatar
authors.affiliation: Department of Patology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Sen
authors.affiliation: Department of Radiology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Harman
authors.affiliation: Department of Nephrology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.affiliation: Department of Nephrology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Ozkan
authors.initials: O
authors.lastname: Gungor
authors.affiliation: Department of Patology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Sarsik
authors.affiliation: Department of Nephrology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Gulay
authors.initials: G
authors.lastname: Asci
authors.affiliation: Department of General Surgery, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Cuneyt
authors.initials: C
authors.lastname: Hoscoskun
authors.affiliation: Department of Nephrology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Basci
authors.affiliation: Department of Nephrology, Ege University School of Medicine, Izmir, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Toz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging / Q000473:pathology*; D009929:Organ Size; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Computer tomography; obesity; renal histology; renal transplant donors; renal volume