title: [Genetic diversity and immunological characteristics of malignant melanoma: the therapeutic spectrum].
abstract: Malignant melanoma, originating from pigment cells, is a highly aggressive tumour affecting patients of any age group. Its incidence is rapidly growing. The most common form can be easily diagnosed by any physician. There are some well-known genetic (skin-, eye-, hair colour, naevi, melanoma in the personal/family history) and environmental (ultraviolet radiation) predisposing factors. Treatment is based on early diagnosis and excision. When metastasis occurs, the traditional chemo- and radiotherapy gives a low response rate. Recently some newly approved targeted therapies and immunomodulant drugs have become available. This review focuses on the classification and novel therapeutic approaches of malignant melanoma to provide guidance to clinicians.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Patológiai Intézet Budapest Fejér Megyei Szent György Egyetemi Oktató Kórház Bőrgyógyászati Osztály Székesfehérvár.
authors.forename: Viktória
authors.initials: V
authors.lastname: Doma
authors.affiliation: Magyar Honvédség Egészségügyi Központ Honvédkórház Budapest.
authors.forename: Ernő
authors.initials: E
authors.lastname: Gulya
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D011905:Genes, ras / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D058990:Molecular Targeted Therapy / Q000379:methods; D009154:Mutation; D009367:Neoplasm Staging; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D012307:Risk Factors; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D000096142:Cutaneous Malignant Melanoma
chemical_list: D000970:Antineoplastic Agents; D007155:Immunologic Factors; D019009:Proto-Oncogene Proteins c-kit; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
keywords: célzott terápia; immunotherapy; immunterápia; jelátviteli útvonal; malignant melanoma; malignus melanoma; signal pathway; targeted therapy