title: An official American Thoracic Society/European Respiratory Society statement: research questions in COPD.
abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) research statement is to describe evidence related to diagnosis, assessment and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified. Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS research statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes.
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Bartolome R
authors.initials: BR
authors.lastname: Celli
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Marc
authors.initials: M
authors.lastname: Decramer
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Jadwiga A
authors.initials: JA
authors.lastname: Wedzicha
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Wilson
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Alvar
authors.initials: A
authors.lastname: Agustí
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Criner
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: William
authors.initials: W
authors.lastname: MacNee
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Make
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Rennard
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stockley
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Claus
authors.initials: C
authors.lastname: Vogelmeier
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Antonio
authors.initials: A
authors.lastname: Anzueto
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: David H
authors.initials: DH
authors.lastname: Au
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barnes
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Pierre-Regis
authors.initials: PR
authors.lastname: Burgel
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Calverley
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Ciro
authors.initials: C
authors.lastname: Casanova
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Enrico M
authors.initials: EM
authors.lastname: Clini
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Cooper
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Harvey O
authors.initials: HO
authors.lastname: Coxson
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Dusser
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Leonardo M
authors.initials: LM
authors.lastname: Fabbri
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Fahy
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Gary T
authors.initials: GT
authors.lastname: Ferguson
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Andrew
authors.initials: A
authors.lastname: Fisher
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Monica J
authors.initials: MJ
authors.lastname: Fletcher
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Maurice
authors.initials: M
authors.lastname: Hayot
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: John R
authors.initials: JR
authors.lastname: Hurst
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Jones
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Donald A
authors.initials: DA
authors.lastname: Mahler
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: François
authors.initials: F
authors.lastname: Maltais
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: David M
authors.initials: DM
authors.lastname: Mannino
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Fernando J
authors.initials: FJ
authors.lastname: Martinez
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Marc
authors.initials: M
authors.lastname: Miravitlles
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Paula M
authors.initials: PM
authors.lastname: Meek
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Alberto
authors.initials: A
authors.lastname: Papi
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Rabe
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Roche
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Frank C
authors.initials: FC
authors.lastname: Sciurba
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Sethi
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Nikos
authors.initials: N
authors.lastname: Siafakas
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Don D
authors.initials: DD
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.initials: JB
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: James K
authors.initials: JK
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.initials: DP
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Thierry
authors.initials: T
authors.lastname: Troosters
authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.initials: GM
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Johny
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
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authors.initials: GR
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Robert A
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Emiel F M
authors.initials: EF
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authors.affiliation: Further details of this ATS/ERS Task Force for COPD Research can be found in the acknowledgements section. Project co-chairs; should be considered co-first authors.
authors.forename: Richard L
authors.initials: RL
authors.lastname: ZuWallack
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration*; D019468:Disease Management; D005060:Europe; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D012955:Societies, Medical / Q000458:organization & administration*; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D014481:United States