title: Antisynthetase Syndrome: two case report and literature review.
abstract: Antissintetase Syndrome (ASS) is characterized by myositis, Raunaud's phenomenon, fever, intertitial lung disease, mechanic's hands and arthropathy associated with the presence of antibodies against tRNA synthetase, especially anti-Jo-1. This article aims to review the literature on ASS and report two cases where the first is a patient with polymyositis who developed subluxation on the proximal interphalangeal joint of bilateral first right finger after a few years of the disease, associated with pulmonary manifestations and positive anti-JO-1. In the second case, we present a patient with dermatomyositis, who developed a subluxation of the two first fingers, anti-Jo1 positive and chest CT changes, but without clinical evidence of pulmonary involvement. These cases reveal the importance of performing early diagnosis. The authors describe two cases of this rare syndrome, emphasizing the severity of interstitial lung disease and arthritis.
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Lívia Regina
authors.initials: LR
authors.lastname: Theilacker
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Fabíola Sampaio
authors.initials: FS
authors.lastname: Brandão
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Fernanda Velloso
authors.initials: FV
authors.lastname: Goulart
authors.affiliation: Disciplina de Reumatologia, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: João Luiz Pereira
authors.initials: JL
authors.lastname: Vaz
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Luiz Octávio Dias
authors.initials: LO
authors.lastname: D'Almeida
authors.affiliation: Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil; Disciplina de Reumatologia, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. Electronic address: cecilsalgado@yahoo.com.br.
authors.forename: Maria Cecília
authors.initials: MC
authors.lastname: da Fonseca Salgado
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis*
keywords: Anti Jo1; Antissintetase Syndrome; Anti‐Jo 1; Doença intersticial pulmonar; Interstitial lung disease; Polidermatomiosite; Polydermatomyositis; Síndrome antissintetase