title: Combination of Paris and Vienna classifications may optimize follow-up of gastric epithelial neoplasia patients.
abstract: BACKGROUND
  The aim of this study was to evaluate the efficiency of the combination of Paris and Vienna classifications in a follow-up study of gastric epithelial neoplasia (GEN) patients.
  
  
  METHODS
  This study was conducted between January 2003 and September 2010, during which 170 biopsy-proven GEN patients were followed up by gastroenterologists and pathologists according to our follow-up regimen (modified Vienna classification).
  
  
  RESULTS
  In total, 161 patients with low-grade neoplasia (LGN) and 9 patients with high-grade neoplasia (HGN) were randomly enrolled in our study. Eighteen patients with depressed appearance were observed, of which 9 patients had HGN and 9 patients had low-grade dysplasia (LGD). Three patients with type 0-IIa were observed with low-grade adenoma (LGA), and type 0-I was observed in 2 patients with LGN. Endoscopic or surgical treatments were performed to avoid potential malignancy or bleeding. Two patients with ulcer lesions, 2 patients with non-depressed type 0 appearance, and 3 patients without visible lesions were shown to have higher-grade lesions during follow-up. The misdiagnosis rate of forceps biopsy - 62.07% - was determined by comparing pre- and post-resection diagnoses of 29 patients.
  
  
  CONCLUSIONS
  The combination of the Paris and Vienna classifications for GEN may optimize the follow-up routines for patients with suspicious precancerous lesions and may significantly improve the detection of early gastric cancer (EGC) while helping gastroenterologists select the best therapy option.
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital Binjiang Campus, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.affiliation: Department of Gastroenterology, Zhuhai Hospital, Jinan University College of Medicine, Zhuhai, Guangdong, China (mainland).
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Ai
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital Binjiang Campus, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
authors.forename: Yi-Miao
authors.initials: YM
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Fourth Affiliated Hospital, School of Medicine, Zhejiang University, Yiwu, Zhejiang, China (mainland).
authors.forename: Tie-Mei
authors.initials: TM
authors.lastname: Han
authors.affiliation: Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.affiliation: Department of Gastroenterology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China (mainland).
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003710:Demography; D004848:Epithelium / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome
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