title: A slow-release system of bacterial cellulose gel and nanoparticles for hydrophobic active ingredients.
abstract: A combination of bacterial cellulose (BC) gel and amphiphilic block copolymer nanoparticles was investigated as a drug delivery system (DDS) for hydrophobic active ingredients. Poly(ethylene oxide)-b-poly(caprolactone) (PEO-b-PCL) and retinol were used as the block copolymer and hydrophobic active ingredient, respectively. The BC gel was capable of incorporating copolymer nanoparticles and releasing them in an acetic acid-sodium acetate buffer solution (pH 5.2) at 37 °C. The percentage of released copolymer reached a maximum value of approximately 60% after 6h and remained constant after 24h. The percentage of retinol released from the copolymer-containing BC gel reached a maximum value at 4h. These results show that the combination of BC gel and nanoparticles is a slow-release system that may be useful in the cosmetic and biomedical fields for skin treatment and preparation.
authors.affiliation: Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France; Department of Materials Chemistry, Asahikawa National College of Technology, Asahikawa 071-8142, Japan. Electronic address: numata@res.otaru-uc.ac.jp.
authors.forename: Yukari
authors.initials: Y
authors.lastname: Numata
authors.affiliation: Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France; Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
authors.forename: Leticia
authors.initials: L
authors.lastname: Mazzarino
authors.affiliation: Centre de Recherches sur les Macromoléculés Végétales (CERMAV, UPR-CNRS 5301), Université Grenoble Alpes, BP 53, F-38041 Grenoble Cedex 9, France.
authors.forename: Redouane
authors.initials: R
authors.lastname: Borsali
mesh_terms: D002482:Cellulose / Q000096:biosynthesis / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005782:Gels; D041822:Gluconacetobacter xylinus / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D007783:Lactones / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D014801:Vitamin A / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005782:Gels; D007783:Lactones; C521904:poly(ethylene glycol)-block-poly(epsilon-caprolactone); D014801:Vitamin A; D011092:Polyethylene Glycols; D002482:Cellulose
keywords: Bacterial cellulose gel; Biocompatibility; Block copolymer; Drug delivery system; Nanoparticles; Retinol; Retinol (PubChem CID: 445354)