title: Characterization of multiple NDM-1-producing Enterobacteriaceae isolates from the same patient.
abstract: A male patient was admitted to a community hospital in Ontario, Canada, with an infected sacral ulcer after returning from India, where he was hospitalized. Carbapenem-resistant Escherichia coli (isolated from blood cultures), Enterobacter cloacae, and Providencia stuartii (from urine samples), all positive for bla(NDM-1), were recovered. Comparative NDM-1 plasmid analysis suggests both lateral plasmid transfer and independent acquisition of the bla(NDM-1) gene in these clinical isolates.
authors.affiliation: Public Health Ontario Laboratories, Toronto, Ontario, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Tijet
authors.affiliation: Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada Department of Laboratory Medicine, McMaster University, Hamilton, Ontario, Canada Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Richardson
authors.affiliation: Public Health Ontario Laboratories, Toronto, Ontario, Canada.
authors.forename: Gregory
authors.initials: G
authors.lastname: MacMullin
authors.affiliation: Public Health Ontario Laboratories, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Samir N
authors.initials: SN
authors.lastname: Patel
authors.affiliation: Public Health Ontario Laboratories, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Department of Microbiology, Mt. Sinai Hospital, Toronto, Ontario, Canada roberto.melano@oahpp.ca.
authors.forename: Roberto G
authors.initials: RG
authors.lastname: Melano
mesh_terms: D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D011532:Providencia / Q000187:drug effects / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
references.citation: J Microbiol Methods. 2005 Dec;63(3):219-28
references.pmid: 15935499
references.citation: Mol Microbiol. 2006 Jun;60(5):1136-51
references.pmid: 16689791
references.citation: Clin Microbiol Rev. 2007 Jul;20(3):440-58, table of contents
references.pmid: 17630334
references.citation: BMC Genomics. 2008;9:75
references.pmid: 18261238
references.citation: Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54
references.pmid: 19770275
references.citation: Emerg Infect Dis. 2011 Jan;17(1):103-6
references.pmid: 21192866
references.citation: Antimicrob Agents Chemother. 2011 Feb;55(2):904-9
references.pmid: 21078935
references.citation: Antimicrob Agents Chemother. 2011 Feb;55(2):934-6
references.pmid: 21115785
references.citation: Emerg Infect Dis. 2011 Feb;17(2):306-7
references.pmid: 21291614
references.citation: Diagn Microbiol Infect Dis. 2011 Dec;71(4):474-5
references.pmid: 22083082
references.citation: Antimicrob Agents Chemother. 2012 Feb;56(2):783-6
references.pmid: 22123704
references.citation: Clin Infect Dis. 2012 Dec;55(11):e109-17
references.pmid: 22997214
references.citation: Antimicrob Agents Chemother. 2013 Aug;57(8):4072-6
references.pmid: 23752513
references.citation: Biomed Res Int. 2014;2014:249856
references.pmid: 24790993