title: Plasma vitamin D metabolites and C-reactive protein in stage-stop racing endurance sled dogs.
abstract: BACKGROUND
  Dogs are a unique model for examining the effects of exercise on vitamin D status because of their lack of vitamin D synthesis by UV exposure. In addition, the inflammatory response may be associated with hypovitaminosis D.
  
  
  OBJECTIVE
  To investigate the effects of several days of endurance exercise on plasma vitamin D (25-(OH)D3, 24,25-(OH)D3 and 1,25(OH)D3) and serum C-reactive protein (CRP) concentrations in stage-stop racing sled dogs.
  
  
  METHODS
  12 racing sled dogs and 8 control dogs.
  
  
  METHODS
  Blood was collected before the race and immediately after racing on days 2 and 8. Plasma vitamin D metabolites and serum CRP concentrations were measured.
  
  
  RESULTS
  Racing dogs showed a significant increase in 25(OH)D3 on day 2 (P = .027) and day 8 of the race (P < .001), whereas no increases were observed in control dogs. The plasma concentration of 24,25(OH)D3 showed a significant increase by day 8 (P < .001). There were no significant changes in 1,25(OH) D3 concentrations across all time points and groups. Racing dogs had significantly increased CRP concentrations by day 2 (39.3 ± 30.1 μg/mL; P < .001).
  
  
  CONCLUSIONS
  Increases in vitamin D metabolites as well as increases in CRP concentrations were observed in racing sled dogs. This finding was contrary to the hypothesis that decreases in vitamin D status in athletes may be related to the acute phase inflammatory response during exercise. In addition, the increased 24,25(OH)D3 concentrations compared to what is observed in other species suggests metabolic variations in dogs that lead to enhanced disposal of vitamin D.
authors.affiliation: Best Care Pet Hospital, Sioux Falls, SD.
authors.forename: J W
authors.initials: JW
authors.lastname: Spoo
authors.forename: R L
authors.initials: RL
authors.lastname: Downey
authors.forename: C
authors.initials: C
authors.lastname: Griffitts
authors.forename: R J
authors.initials: RJ
authors.lastname: Horst
authors.forename: C B
authors.initials: CB
authors.lastname: Levine
authors.forename: R M
authors.initials: RM
authors.lastname: Childs
authors.forename: J J
authors.initials: JJ
authors.lastname: Wakshlag
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D004285:Dogs / Q000097:blood* / Q000378:metabolism; D010807:Physical Endurance; D013177:Sports; D014807:Vitamin D / Q000097:blood / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D002097:C-Reactive Protein
keywords: Endocrinology; Metabolism; Nutrition; Physiology; Sports medicine; Vitamins and minerals
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