title: MicroRNAs in inflammatory bowel diseases: paradoxes and possibilities.
abstract: MicroRNAs (miRNAs) are single-stranded RNA molecules, which influence the translation of messenger RNA and hence protein synthesis. The altered expression of miRNAs in disease states in cancer and autoimmune diseases including inflammatory bowel disease is providing new insights into disease pathogenesis. This understanding is leading to consideration of the utility of miRNAs in diagnostics, prognostics, and therapeutics in inflammatory bowel disease. A literature search was conducted using the MEDLINE/PubMed databases using search terms inflammatory bowel disease, miRNA, treatment, and biomarkers.
authors.affiliation: *Department of Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom; and †Department of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.
authors.forename: Simon R
authors.initials: SR
authors.lastname: Whiteoak
authors.forename: Richard
authors.initials: R
authors.lastname: Felwick
authors.forename: Tilman
authors.initials: T
authors.lastname: Sanchez-Elsner
authors.forename: J R
authors.initials: JR
authors.lastname: Fraser Cummings
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs