title: Prospective, randomized comparison of same-day dose of 2 different bowel cleanser for afternoon colonoscopy: picosulfate, magnesium oxide, and citric acid versus polyethylene glycol.
abstract: For afternoon colonoscopy, same-day administration of sodium picosulfate, magnesium oxide, and citric acid (PM/Ca) is recommended. However, few studies have evaluated the bowel-cleansing efficacy and safety of this regimen. The aim of this study was to compare the bowel-cleansing efficacy, side effects, and patient's tolerability of a same-day split administration of PM/Ca with polyethylene glycol (PEG) for afternoon colonoscopy. Patients were randomly assigned to a PM/Ca group or a PEG group. The PM/Ca group consumed 1 sachet of PM/Ca at 06:00 and 1 sachet of PM/Ca 4 hours before the colonoscopy. They also took 2 tablets of bisacodyl before sleep on the night before. The PEG group consumed 2 L of PEG at 06:00 and 2 L of PEG 4 hours before the colonoscopy. All subjects were instructed to finish the bowel cleanser or fluid at least 2 hours before colonoscopy. All colonoscopic examinations were performed in the afternoon on the same day. The bowel-cleansing efficacy was scored using 2 scales: the Ottawa Bowel Preparation Scale (OBPS) and the Aronchick scale. Ease of using the bowel cleanser was rated from 1 (very easy) to 5 (very difficult). Two hundred nine patients underwent colonoscopy. The bowel-cleansing scores by OBPS did not differ between groups (5.0 vs 4.9, P = 0.63). Ease of using the bowel cleanser was superior in the PM/Ca group (P < 0.01). The cleansing efficacy of PM/Ca administered on the day of colonoscopy is comparable to that of PEG. Patients prefer PM/Ca.
authors.affiliation: From the Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, College of Medicine.
authors.forename: Tae-Geun
authors.initials: TG
authors.lastname: Gweon
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Yong-Sun
authors.initials: YS
authors.lastname: Noh
authors.forename: Seawon
authors.initials: S
authors.lastname: Hwang
authors.forename: Na-Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Yoonbum
authors.initials: Y
authors.lastname: Lee
authors.forename: Soon-Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Jong Yul
authors.initials: JY
authors.lastname: Lee
authors.forename: Chul-Hyun
authors.initials: CH
authors.lastname: Lim
authors.forename: Hyung
authors.initials: H
authors.lastname: Hun Kim
authors.forename: Jin Su
authors.initials: JS
authors.lastname: Kim
authors.forename: Yu
authors.initials: Y
authors.lastname: Kyung Cho
authors.forename: Jae
authors.initials: J
authors.lastname: Myung Park
authors.forename: In
authors.initials: I
authors.lastname: Seok Lee
authors.lastname: Myung-Gyu Choi
mesh_terms: D000328:Adult; D001726:Bisacodyl / Q000627:therapeutic use; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002951:Citrates / Q000627:therapeutic use; D019343:Citric Acid / Q000627:therapeutic use; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008277:Magnesium Oxide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use; D010847:Picolines / Q000627:therapeutic use; D011092:Polyethylene Glycols / Q000627:therapeutic use; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010847:Picolines; D001726:Bisacodyl; D019343:Citric Acid; D008277:Magnesium Oxide; D011092:Polyethylene Glycols; C005701:picosulfate sodium
references.citation: Drugs. 2008;68(4):417-37
references.pmid: 18318561
references.citation: Endoscopy. 2007 Jul;39(7):616-9
references.pmid: 17611916
references.citation: Endoscopy. 2009 Dec;41(12):1038-45
references.pmid: 19967619
references.citation: Gastrointest Endosc. 2010 Aug;72(2):313-20
references.pmid: 20561621
references.citation: Am J Gastroenterol. 2010 Sep;105(9):1954-61
references.pmid: 20407434
references.citation: Am J Gastroenterol. 2010 Nov;105(11):2368-74
references.pmid: 20606677
references.citation: Am J Gastroenterol. 2010 Nov;105(11):2318-22
references.pmid: 21048676
references.citation: Dig Dis Sci. 2011 Feb;56(2):539-44
references.pmid: 21042853
references.citation: Endoscopy. 2011 May;43(5):412-8
references.pmid: 21547879
references.citation: Gastrointest Endosc. 2011 Jun;73(6):1207-14
references.pmid: 21481857
references.citation: J Clin Gastroenterol. 2012 Jan;46(1):57-61
references.pmid: 22064553
references.citation: Can J Gastroenterol. 2012 Jul;26(7):424-8
references.pmid: 22803016
references.citation: Endoscopy. 2013;45(2):142-50
references.pmid: 23335011
references.citation: Am J Gastroenterol. 2013 Mar;108(3):401-9
references.pmid: 23318484
references.citation: Dig Dis Sci. 2013 Apr;58(4):926-35
references.pmid: 23095990
references.citation: Gastrointest Endosc. 2013 Jul;78(1):132-41
references.pmid: 23566639
references.citation: Gastrointest Endosc. 2000 Sep;52(3):346-52
references.pmid: 10968848
references.citation: Am J Gastroenterol. 2001 Jun;96(6):1797-802
references.pmid: 11419832
references.citation: Surg Endosc. 2006 Jul;20(7):1147-60
references.pmid: 16763922
references.citation: Am J Gastroenterol. 2006 Dec;101(12):2726-30
references.pmid: 17227519
references.citation: Drugs. 2009;69(1):123-36
references.pmid: 19192941