title: Efficient approach to 2-hydroxy-2,3-dihydrofuran derivatives and its application for the synthesis of novel 4-(1H-pyrazol-4-yl)pyridazines.
abstract: A highly efficient method for the synthesis of 2-hydroxy-2,3-dihydrofuran derivatives from 1,4-enediones and phenacyl pyridinium halides via a domino reaction has been developed. This is a simple and beneficial strategy for the construction of 2-hydroxy-2,3-dihydrofuran compounds from readily available starting materials under mild conditions. Moreover, the application of this reaction provides a straightforward and practical route for the synthesis of the novel 4-(1H-pyrazol-4-yl)pyridazine skeleton.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chwuax@mail.ccnu.edu.cn.
authors.forename: Jun-Rui
authors.initials: JR
authors.lastname: Ma
authors.forename: Wen-Ming
authors.initials: WM
authors.lastname: Shu
authors.forename: Kai-Lu
authors.initials: KL
authors.lastname: Zheng
authors.forename: Fan
authors.initials: F
authors.lastname: Ni
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Yin
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wu
mesh_terms: D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry; D011726:Pyridinium Compounds / Q000737:chemistry*
chemical_list: D005663:Furans; D006846:Hydrocarbons, Halogenated; D007659:Ketones; D011720:Pyrazoles; D011724:Pyridazines; D011726:Pyridinium Compounds