title: A study on the status of inflammatory systems in camels naturally infected with Toxoplasma gondii.
abstract: Toxoplasma gondii is a unique intracellular parasite with a worldwide distribution. This parasite infects a variety of cells in a wide range of animal species such as dromedary camels (Camelus dromedarius). In order to evaluate the pattern of possible changes in the blood level of some inflammatory mediators and antioxidant enzymes in camels infected with T. gondii, blood samples were taken from a total of 493 dromedary camels and serum concentrations of inflammatory mediators, acute phase proteins and antioxidant enzymes were measured. According to serological data, no seropositivity was found for anti-T. gondii IgM in serum samples; however, 49 camels (9.93 %) showed positive titrations for anti-Toxoplasma IgG. The analyses of data in seropositive animals showed significant increases (P < 0.05) in the serum level of IL-1β and adenosine deaminase activity; however, IFN-γ and TNF-α demonstrated no significant changes in serum samples of the infected camels. In addition, while major acute phase proteins (haptoglobin (Hp) and serum amyloid A (SAA)) were markedly elevated in infected camels, the activity of antioxidant enzymes (SOD and GPX) was remarkably decreased in the blood samples of infected animals. Thus, during the chronic infection in camels, T. gondii can promote significant rises in concentrations of some cytokines (such as IL-1β), acute phase proteins and adenosine deaminase.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Azma
authors.forename: Seyed Mostafa
authors.initials: SM
authors.lastname: Razavi
authors.forename: Saeed
authors.initials: S
authors.lastname: Nazifi
authors.forename: Ehsan
authors.initials: E
authors.lastname: Rakhshandehroo
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Sanati
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood; D000822:Animal Husbandry; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002162:Camelus; D016022:Case-Control Studies; D006242:Haptoglobins / Q000378:metabolism; D007249:Inflammation / Q000662:veterinary; D007371:Interferon-gamma / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D000685:Serum Amyloid A Protein / Q000378:metabolism; D012720:Severity of Illness Index; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000097:blood / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D000913:Antibodies, Protozoan; D006242:Haptoglobins; D053583:Interleukin-1beta; D000685:Serum Amyloid A Protein; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D000243:Adenosine Deaminase
references.citation: Parasitology. 1984 Aug;88 ( Pt 4):579-92
references.pmid: 6387594
references.citation: Trop Biomed. 2011 Aug;28(2):362-5
references.pmid: 22041757
references.citation: Infect Immun. 1992 Jul;60(7):2672-6
references.pmid: 1612737
references.citation: Immunology. 1990 Jan;69(1):33-7
references.pmid: 2107144
references.citation: Klin Wochenschr. 1971 Jun 15;49(12):669-83
references.pmid: 4932493
references.citation: J Nutr. 1974 May;104(5):580-7
references.pmid: 4823943
references.citation: Parasitol Res. 2011 Aug;109(2):275-81
references.pmid: 21301875
references.citation: J Protozool. 1983 May;30(2):351-6
references.pmid: 6631778
references.citation: Vet J. 2004 Jul;168(1):28-40
references.pmid: 15158206
references.citation: J Lab Clin Med. 1967 Jul;70(1):158-69
references.pmid: 6066618
references.citation: J Anim Sci. 2003 May;81(5):1120-5
references.pmid: 12772837
references.citation: Clin Chem. 1992 Jul;38(7):1322-6
references.pmid: 1623598
references.citation: Parasitol Res. 2006 May;98 (6):600-1
references.pmid: 16425066
references.citation: J Infect Dis. 1984 Dec;150(6):961-2
references.pmid: 6438249
references.citation: Parasitol Res. 2009 Jul;105(1):41-6
references.pmid: 19238441
references.citation: Free Radic Res. 2003 Nov;37(11):1181-9
references.pmid: 14703730
references.citation: Vet Res Commun. 2005 Jul;29(5):387-94
references.pmid: 16195933
references.citation: Vet Parasitol. 2011 Aug 25;180(3-4):209-14
references.pmid: 21481533
references.citation: Dev Comp Immunol. 1990 Winter;14(1):95-104
references.pmid: 2338159
references.citation: Vet Parasitol. 1992 Jul;43(3-4):171-5
references.pmid: 1413449
references.citation: J Zhejiang Univ Sci B. 2005 Nov;6(11):1045-56
references.pmid: 16252337
references.citation: Clin Exp Immunol. 1989 Sep;77(3):397-402
references.pmid: 2553309
references.citation: Vet J. 2007 May;173(3):669-74
references.pmid: 16584904
references.citation: Parasitol Res. 2003 Feb;89(3):228-34
references.pmid: 12541066
references.citation: Science. 1988 Apr 22;240(4851):516-8
references.pmid: 3128869
references.citation: Eur J Clin Microbiol Infect Dis. 1998 Jan;17(1):32-6
references.pmid: 9512179
references.citation: Indian J Med Microbiol. 2001 Jul-Sep;19(3):145-8
references.pmid: 17664818