title: Association of PPAR-γ2 and β3-AR Polymorphisms With Postmenopausal Hypertension.
abstract: The aim of this study was to test the association of peroxisome proliferator-activated receptor (PPAR-γ2) (Pro12Ala, C1431T) and β3-AR (Trp64Arg) polymorphisms with metabolic, nutritional, and blood pressure parameters in 271 postmenopausal women (151 hypertensive and 120 normotensive controls). The TaqMan genotyping assay and restriction fragment length polymorphism methods were used to determine the distributions of selected alleles and genotype frequencies. Nutritional status was determined by a bioimpedance method and dietary habits were assessed via 7-day dietary recall. The distribution of selected genotypes and allele frequencies did not differ between hypertensive women and normal controls after analysis by chi-square test. The postmenopausal hypertensive women were older and had higher body fat mass, serum glucose, and triglyceride levels. The cluster analysis showed that the hypertensive group with Pro12Pro genotype had highest pulse pressure and mean arterial pressure values when compared with Pro12Ala patients. In the logistic regression analysis, blood glucose (Pro12Ala polymorphism) and energy intake (C1431Tand T1431T polymorphisms) determined hypertension.
authors.affiliation: Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Bogna
authors.initials: B
authors.lastname: Grygiel-Górniak
authors.affiliation: Department of Bioinformatics and Computational Biology, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Kaczmarek
authors.affiliation: Department of Molecular Pathology, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Mosor
authors.affiliation: Department of Bromatology and Human Nutrition, Poznan University of Medical Sciences, Poznan, Poland.
authors.forename: Juliusz
authors.initials: J
authors.lastname: Przysławski
authors.affiliation: Department of Molecular Pathology, Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nowak
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000235:genetics; D002149:Energy Intake; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D047495:PPAR gamma / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics* / Q000378:metabolism; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D047495:PPAR gamma; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides
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