title: Synthesis of folic acid functionalized redox-responsive magnetic proteinous microcapsules for targeted drug delivery.
abstract: Folic acid (FA) functionalized magnetic bovine serum albumin (BSA) microcapsules (FA-MBMCs) were prepared by a facile sonochemical method, in which FA molecule was immobilized onto the outer walls of microcapsules as a targeting ligand and oleic acid (OA) modifying Fe3O4 magnetic nanoparticles (OA-Fe3O4 MNPs) were wrapped into the microcapsules. The obtained FA-MBMCs possessed a nice spherical morphology with the mean size of 1.4 μm. FA-MBMCs also showed an excellent magnetic and molecular dual-targeted property. Besides, the reductant-triggered diffusion of coumarin 6 suggested superior drug controlled release of FA-MBMCs.
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Zhanfeng
authors.initials: Z
authors.lastname: Li
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Songfeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Shurong
authors.initials: S
authors.lastname: Wang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Linhui
authors.initials: L
authors.lastname: Qiang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: wang_hy@jlu.edu.cn.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Interfaces, Max Planck Institute of Colloids and Interfaces, Potsdam 14476, Germany.
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.affiliation: College of Chemistry, Jilin University, Changchun 130012, China. Electronic address: cui_xj@jlu.edu.cn.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Cui
mesh_terms: D000818:Animals; D002214:Capsules; D002417:Cattle; D016503:Drug Delivery Systems; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D002214:Capsules; D012710:Serum Albumin, Bovine; D019301:Oleic Acid; D005492:Folic Acid; D052203:Ferrosoferric Oxide
keywords: Dual-targeted; Folic acid; Microcapsule; Reductant-triggered; Sonochemical