title: Efficient synthesis of C-N-coupled heterobiaryls by sequential N-H functionalization reactions.
abstract: C-N-coupled heterobiaryls were synthesized by sequential N-H functionalization reactions: stereoselective rhodium-catalyzed N-H insertion, followed by regioselective palladium-catalyzed C-H amination. Because of the good substrate scope and excellent selectivity, the developed method presents a novel approach for the synthesis of heterobiaryls, which are potent antibiotics.
authors.affiliation: Department of Chemistry, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic