title: Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome.
abstract: OBJECTIVE
  Wells syndrome (WS) (eosinophilic cellulitis) is an uncommon eosinophilic dermatitis that has been rarely described in association with, but distinct from, hypereosinophilic syndrome (HES).
  
  
  METHODS
  We report a case of an eosinophilic dermatosis with flame figures in association with idiopathic HES, manifested by inflammatory myocarditis, asthma, and peripheral blood eosinophilia.
  
  
  CONCLUSIONS
  The diagnoses of WS and HES, rather than being distinct findings, may represent 2 entities on a spectrum of hypereosinophilic diseases. The diagnosis of WS should be made with caution and should prompt a thorough investigation that includes a work-up for a systemic eosinophilic disorder.
authors.affiliation: Departments of *Dermatology, and †Pathology, Wexner Medical Center, The Ohio State University, Columbus, OH.
authors.forename: Sabrina M
authors.initials: SM
authors.lastname: Smith
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Kiracofe
authors.forename: Lindsey N
authors.initials: LN
authors.lastname: Clark
authors.forename: Alejandro A
authors.initials: AA
authors.lastname: Gru
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology; D002481:Cellulitis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D002607:Charcot-Marie-Tooth Disease / Q000453:epidemiology*; D015897:Comorbidity; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000453:epidemiology
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