title: BDNF Val66Met is Associated With Performance in a Computerized Visual-Motor Tracking Test In Healthy Adults.
abstract: The brain-derived neurotrophic factor gene (BDNF) is known to play an important role in neuroplasticity and cognitive processes. We explored the association of BDNF Val66Met polymorphism with performance in a visual-motor tracking test. One hundred and sixty-seven young, healthy Colombian adults completed a computerized version of the Pursuit Rotor Task, using the Psychology Experiment Building Language (PEBL) platform. DNA genotyping was performed by allele-specific polymerase chain reaction. We found that BDNF Val/Met and Met/Met subjects performed better in the pursuit rotor task (p = .03). Our findings suggest that the BDNF gene is essential to understand differences in motor performance in healthy participants in different populations. This approach could be useful for future fine mapping of genetic modifiers for neuropsychiatric diseases.
authors.affiliation: Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine, Universidad Antonio Nariño, Bogotá, Colombia.
authors.forename: Yeimy
authors.initials: Y
authors.lastname: González-Giraldo
authors.forename: Johana
authors.initials: J
authors.lastname: Rojas
authors.forename: Shane T
authors.initials: ST
authors.lastname: Mueller
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Piper
authors.forename: Ana
authors.initials: A
authors.lastname: Adan
authors.forename: Diego A
authors.initials: DA
authors.lastname: Forero
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011597:Psychomotor Performance / Q000502:physiology*; D012044:Regression Analysis; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor