title: Minimal conductance-based model of auditory coincidence detector neurons.
abstract: Sound localization is a fundamental sensory function of a wide variety of animals. The interaural time difference (ITD), an important cue for sound localization, is computed in the auditory brainstem. In our previous modeling study, we introduced a two-compartment Hodgkin-Huxley type model to investigate how cellular and synaptic specializations may contribute to precise ITD computation of the barn owl's auditory coincidence detector neuron. Although our model successfully reproduced fundamental physiological properties observed in vivo, it was unsuitable for mathematical analyses and large scale simulations because of a number of nonlinear variables. In the present study, we reduce our former model into three types of conductance-based integrate-and-fire (IF) models. We test their electrophysiological properties using data from published in vivo and in vitro studies. Their robustness to parameter changes and computational efficiencies are also examined. Our numerical results suggest that the single-compartment active IF model is superior to other reduced models in terms of physiological reproducibility and computational performance. This model will allow future theoretical studies that use more rigorous mathematical analysis and network simulations.
authors.affiliation: Cluster of Excellence "Hearing4all", Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
authors.forename: Go
authors.initials: G
authors.lastname: Ashida
authors.affiliation: Systems Biology, Osaka Bioscience Institute, Suita, Osaka, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Funabiki
authors.affiliation: Cluster of Excellence "Hearing4all", Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
authors.forename: Jutta
authors.initials: J
authors.lastname: Kretzberg
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D013017:Sound Localization / Q000502:physiology*; D020305:Strigiformes / Q000502:physiology*
references.citation: Nature. 1996 Sep 5;383(6595):76-81
references.pmid: 8779718
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13480-5
references.pmid: 10557346
references.citation: J Neurosci. 2002 Dec 15;22(24):11019-25
references.pmid: 12486197
references.citation: Neural Comput. 1998 Nov 15;10(8):1987-2017
references.pmid: 9804669
references.citation: J Neurosci. 2008 Jul 2;28(27):6914-25
references.pmid: 18596166
references.citation: Biol Cybern. 2006 Aug;95(2):97-112
references.pmid: 16821035
references.citation: Physiol Rev. 2010 Jul;90(3):983-1012
references.pmid: 20664077
references.citation: Nature. 2006 Dec 21;444(7122):1069-72
references.pmid: 17136099
references.citation: Nature. 2002 May 30;417(6888):543-7
references.pmid: 12037566
references.citation: J Neurophysiol. 2006 May;95(5):3113-28
references.pmid: 16467426
references.citation: J Physiol. 2010 Sep 1;588(Pt 17):3187-200
references.pmid: 20519310
references.citation: IEEE Trans Neural Netw. 2004 Sep;15(5):1063-70
references.pmid: 15484883
references.citation: J Neurosci. 1996 Nov 1;16(21):7046-54
references.pmid: 8824340
references.citation: J Neurophysiol. 1998 Dec;80(6):2824-35
references.pmid: 9862887
references.citation: Science. 2006 Oct 6;314(5796):80-5
references.pmid: 17023649
references.citation: J Math Biol. 2004 Dec;49(6):577-603
references.pmid: 15565447
references.citation: Neural Comput. 2003 Jun;15(6):1321-40
references.pmid: 12816575
references.citation: Nat Neurosci. 2010 May;13(5):601-9
references.pmid: 20364143
references.citation: J Neurosci. 1990 Oct;10(10):3227-46
references.pmid: 2213141
references.citation: J Neurophysiol. 2010 Oct;104(4):2274-90
references.pmid: 20685926
references.citation: Front Comput Neurosci. 2013 Nov 08;7:102
references.pmid: 24265615
references.citation: J Neurosci. 2011 Oct 26;31(43):15245-56
references.pmid: 22031870
references.citation: Neuron. 2013 Jun 5;78(5):936-48
references.pmid: 23764292
references.citation: J Neurophysiol. 2009 Dec;102(6):3447-60
references.pmid: 19812289
references.citation: J Neurosci. 1996 Feb 1;16(3):993-1007
references.pmid: 8558268
references.citation: J Neurosci. 2003 Dec 17;23(37):11628-40
references.pmid: 14684865
references.citation: J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2002 Dec;188(11-12):981-92
references.pmid: 12471495
references.citation: Curr Opin Neurobiol. 2011 Oct;21(5):745-51
references.pmid: 21646012
references.citation: Biol Cybern. 2003 Nov;89(5):388-96
references.pmid: 14669019
references.citation: J Neurosci. 2011 Jun 15;31(24):8936-47
references.pmid: 21677177
references.citation: J Neurophysiol. 1990 Aug;64(2):465-88
references.pmid: 2213127
references.citation: Front Comput Neurosci. 2013 Nov 08;7:151
references.pmid: 24265616
references.citation: J Neurosci. 2005 Mar 23;25(12):3046-58
references.pmid: 15788761
references.citation: Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18138-43
references.pmid: 22006305
references.citation: J Speech Lang Hear Res. 2002 Dec;45(6):1249-61
references.pmid: 12546491
references.citation: J Neurophysiol. 2003 Jun;89(6):3097-113
references.pmid: 12783953
references.citation: SIAM J Sci Comput. 2013;35(3):B623-B643
references.pmid: 24058276
references.citation: J Comp Neurol. 1993 Aug 15;334(3):337-55
references.pmid: 8376623
references.citation: J Neurophysiol. 2006 Apr;95(4):2664-77
references.pmid: 16551843
references.citation: J Neurosci. 2010 Oct 6;30(40):13472-87
references.pmid: 20926673
references.citation: Front Neurosci. 2010 Sep 30;4:
references.pmid: 20953249
references.citation: Biol Cybern. 1999 Nov;81(5-6):381-402
references.pmid: 10592015
references.citation: Brain Res. 1993 Nov 19;628(1-2):330-4
references.pmid: 8313166
references.citation: J Physiol. 2012 Nov 15;590(22):5563-9
references.pmid: 22930273
references.citation: J Neurosci. 2009 Jun 24;29(25):7978-90
references.pmid: 19553438
references.citation: J Neurosci. 1997 May 1;17(9):3312-21
references.pmid: 9096164
references.citation: Sci Am. 1993 Apr;268(4):66-73
references.pmid: 8446882
references.citation: J Neurosci. 1994 Sep;14(9):5352-64
references.pmid: 8083740
references.citation: J Neurophysiol. 1969 Jul;32(4):613-36
references.pmid: 5810617
references.citation: J Comput Neurosci. 2000 May-Jun;8(3):183-208
references.pmid: 10809012
references.citation: Biol Cybern. 2008 Jun;98(6):541-59
references.pmid: 18491165
references.citation: J Neurophysiol. 2007 Mar;97(3):2267-82
references.pmid: 17135480
references.citation: Network. 2003 Feb;14(1):137-50
references.pmid: 12613555
references.citation: J Neurosci. 2005 Aug 31;25(35):7887-95
references.pmid: 16135745
references.citation: Trends Neurosci. 2007 Feb;30(2):70-8
references.pmid: 17188761