title: Regulation of stimulus-inducible gene expression in myeloid cells.
abstract: One of the best-characterized and biologically important gene expression programmes in myeloid cells is their response to pro-inflammatory stimuli. Macrophages and DCs in particular are key mediators of immune responses, and are widely-used as prototypes to understand and define the determinants of specific and inducible gene expression. In this review we summarize advances and concepts which have been made towards the understanding of inducible gene expression, with a particular focus on insights gained using the myeloid system as a model. We discuss the emerging concept of layered control of gene regulation and cell identity by different functional classes of transcription factors; and examine recent progress to understanding the molecular processes involved, including the involvement of nucleosome positioning, chromatin modifications, and nuclear architecture. We also address the exciting but less-well understood role of non-coding RNAs in controlling specific gene expression programmes in myeloid and other cell-types.
authors.affiliation: Institute for Research in Cancer & Ageing Nice (IRCAN), Equipe Labellisée Ligue Contre le Cancer, INSERM U1081, CNRS UMR 7284, University of Nice-Sophia Antipolis, Faculty of Medicine, 28 Ave de Valombrose, 06107 Nice, France; Max Planck Institute for Immunobiology and Epigenetics (MPI-IE), Stubeweg 51, 7108 Freiburg, Germany. Electronic address: Simona.SACCANI@unice.fr.
authors.forename: Simona
authors.initials: S
authors.lastname: Saccani
authors.affiliation: C3M, INSERM UMR 1065, University of Nice Sophia-Antipolis, 151, Route de St-Antoine-de-Ginestière, 06204 Nice, France. Electronic address: Michele.TRABUCCHI@unice.fr.
authors.forename: Michele
authors.initials: M
authors.lastname: Trabucchi
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin
keywords: Chromatin; Gene expression; Inflammation; Myeloid; Transcription factor; ncRNA