title: Alcohol intake and risk of incident psoriatic arthritis in women.
abstract: OBJECTIVE
  Alcohol intake has been associated with an increased risk of psoriasis. However, the association between alcohol intake and risk of psoriatic arthritis (PsA) has been unclear. We evaluated the association between alcohol intake and risk of incident PsA in a large cohort of US women.
  
  
  METHODS
  Our present study included a total of 82,672 US women who provided repeated data on alcohol intake over the followup period (1991-2005). Self-reported PsA was validated using the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire. Cox proportional hazards models were used to estimate the age-adjusted and multivariate-adjusted HR and 95% CI for the PsA in association with alcohol intake.
  
  
  RESULTS
  We documented 141 incident PsA cases during 14 years (1,137,763 person-yrs) of followup. Compared to non-drinkers, the multivariate HR for PsA were 0.70 (95% CI 0.48-1.01) for 0.1-14.9 g/day, 1.43 (95% CI 0.67-3.08) for 15.0-29.9 g/day, and 4.45 (95% CI 2.07-9.59) for ≥ 30.0 g/day of cumulative average alcohol intake. Risk estimates were generally consistent when using updated alcohol intake and baseline alcohol intake in 1991 as the exposures, and when the analysis was restricted to those who developed psoriasis during the followup.
  
  
  CONCLUSIONS
  Excessive alcohol intake was associated with an increased risk of incident PsA in a cohort of US women.
authors.affiliation: From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School.
authors.forename: Shaowei
authors.initials: S
authors.lastname: Wu
authors.affiliation: From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School.
authors.forename: Eunyoung
authors.initials: E
authors.lastname: Cho
authors.affiliation: From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School.
authors.forename: Wen-Qing
authors.initials: WQ
authors.lastname: Li
authors.affiliation: From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School.
authors.forename: Jiali
authors.initials: J
authors.lastname: Han
authors.affiliation: From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School. Abrar_qureshi@brown.edu.
authors.forename: Abrar A
authors.initials: AA
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology*; D015535:Arthritis, Psoriatic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D012306:Risk; D057566:Self Report; D014481:United States / Q000453:epidemiology
keywords: ALCOHOL; COHORT STUDY; PSORIATIC ARTHRITIS
references.citation: Clin Exp Dermatol. 2013 Dec;38(8):819-22
references.pmid: 24252076
references.citation: Arthritis Rheumatol. 2014 Feb;66(2):304-10
references.pmid: 24504802
references.citation: Cancer Epidemiol Biomarkers Prev. 2014 Jun;23(6):1080-9
references.pmid: 24876226
references.citation: BMJ. 1999 Dec 11;319(7224):1523-8
references.pmid: 10591709
references.citation: Clin Exp Dermatol. 2001 Jun;26(4):333-7
references.pmid: 11422185
references.citation: Arch Dermatol Res. 2003 Jun;295(2):56-62
references.pmid: 12720008
references.citation: Am J Epidemiol. 1991 Apr 15;133(8):810-7
references.pmid: 2021148
references.citation: Acta Derm Venereol. 1996 Jul;76(4):260-3
references.pmid: 8869679
references.citation: Br J Dermatol. 1996 Nov;135(5):746-51
references.pmid: 8977675
references.citation: Am J Epidemiol. 1999 Mar 15;149(6):531-40
references.pmid: 10084242
references.citation: N Engl J Med. 2005 Jan 20;352(3):245-53
references.pmid: 15659724
references.citation: Br J Dermatol. 2005 May;152(5):915-9
references.pmid: 15888146
references.citation: J Am Acad Dermatol. 2005 Oct;53(4):573
references.pmid: 16198775
references.citation: Arch Intern Med. 2006 Dec 11-25;166(22):2437-45
references.pmid: 17159008
references.citation: Photodermatol Photoimmunol Photomed. 2007 Aug;23(4):130-4
references.pmid: 17598866
references.citation: Lancet. 2007 Jul 21;370(9583):263-71
references.pmid: 17658397
references.citation: J Am Acad Dermatol. 2007 Oct;57(4):581-7
references.pmid: 17610990
references.citation: Br J Dermatol. 2008 Jan;158(1):138-40
references.pmid: 17999698
references.citation: J Eur Acad Dermatol Venereol. 2008 Jun;22(6):712-7
references.pmid: 18312327
references.citation: Alcohol Clin Exp Res. 2009 Feb;33(2):220-32
references.pmid: 19053973
references.citation: Nat Clin Pract Rheumatol. 2009 Feb;5(2):83-91
references.pmid: 19182814
references.citation: Lancet. 2009 Jun 27;373(9682):2223-33
references.pmid: 19560604
references.citation: Clin Exp Dermatol. 2009 Aug;34(6):698-701
references.pmid: 19438541
references.citation: N Engl J Med. 2009 Jul 30;361(5):496-509
references.pmid: 19641206
references.citation: Arch Dermatol Res. 2009 Sep;301(8):573-9
references.pmid: 19603175
references.citation: Br J Dermatol. 2009 Oct;161(4):778-84
references.pmid: 19566664
references.citation: Circulation. 2010 May 4;121(17):1951-9
references.pmid: 20439811
references.citation: Br J Dermatol. 2010 Apr;162(4):711-6
references.pmid: 19922527
references.citation: J Dermatol. 2010 May;37(5):426-30
references.pmid: 20536647
references.citation: Clin Exp Dermatol. 2010 Dec;35(8):923-5
references.pmid: 20500519
references.citation: Arthritis Rheum. 2010 Dec;62(12):3554-9
references.pmid: 20827783
references.citation: Arch Dermatol. 2010 Dec;146(12):1364-9
references.pmid: 20713772
references.citation: Arthritis Care Res (Hoboken). 2011 Aug;63(8):1091-7
references.pmid: 21560259
references.citation: PLoS Med. 2011 Sep;8(9):e1001090
references.pmid: 21909248
references.citation: Int J Dermatol. 2011 Nov;50(11):1323-31
references.pmid: 22004481
references.citation: JAMA. 2011 Nov 2;306(17):1884-90
references.pmid: 22045766
references.citation: J Dermatol. 2012 Sep;39(9):770-3
references.pmid: 22568495
references.citation: Rheumatology (Oxford). 2013 Mar;52(3):510-4
references.pmid: 23175569
references.citation: Skin Pharmacol Physiol. 2013;26(3):119-26
references.pmid: 23549156
references.citation: J Eur Acad Dermatol Venereol. 2013 Aug;27 Suppl 3:30-5
references.pmid: 23845150
references.citation: Rheumatology (Oxford). 2013 Sep;52(9):1701-7
references.pmid: 23793744
references.citation: BMJ. 2013;347:f6633
references.pmid: 24231178