title: Colonization of extended-spectrum-β-lactamase- and NDM-1-producing Enterobacteriaceae among pregnant women in the community in a low-income country: a potential reservoir for transmission of multiresistant Enterobacteriaceae to neonates.
abstract: The spread of extended-spectrum-β-lactamase-producing Enterobacteriaceae (ESBL-PE) in low-income countries, where the burden of neonatal sepsis is high, may have a serious impact on neonatal mortality rates. Given the potential for mother-to-child transmission of multiresistant bacteria, this study investigated the ESBL-PE rectal colonization among pregnant women at delivery in the community in Madagascar and estimated a prevalence of 18.5% (95% confidence interval, 14.5% to 22.6%). One strain of Klebsiella pneumoniae isolated was also a New Delhi metallo-β-lactamase-1 (NDM-1) producer.
authors.affiliation: Inserm UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Paris, France Institut Pasteur, UMR 1181, B2PHI, Paris, France University Versailles St-Quentin-en-Yvelines, UMR 1181, Biostatistics, B2PHI, Montigny-le-Bretonneux, France fanny.chereau@inserm.fr.
authors.forename: Fanny
authors.initials: F
authors.lastname: Chereau
authors.affiliation: Epidemiology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
authors.forename: Perlinot
authors.initials: P
authors.lastname: Herindrainy
authors.affiliation: Laboratoire de Bactériologie Expérimentale, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
authors.forename: Benoit
authors.initials: B
authors.lastname: Garin
authors.affiliation: Inserm UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Paris, France Institut Pasteur, UMR 1181, B2PHI, Paris, France University Versailles St-Quentin-en-Yvelines, UMR 1181, Biostatistics, B2PHI, Montigny-le-Bretonneux, France.
authors.forename: Bich-Tram
authors.initials: BT
authors.lastname: Huynh
authors.affiliation: Centre de Biologie Clinique, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
authors.forename: Frederique
authors.initials: F
authors.lastname: Randrianirina
authors.affiliation: Inserm UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Paris, France Institut Pasteur, UMR 1181, B2PHI, Paris, France University Versailles St-Quentin-en-Yvelines, UMR 1181, Biostatistics, B2PHI, Montigny-le-Bretonneux, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Padget
authors.affiliation: Epidemiology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
authors.forename: Patrice
authors.initials: P
authors.lastname: Piola
authors.affiliation: Inserm UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Paris, France Institut Pasteur, UMR 1181, B2PHI, Paris, France University Versailles St-Quentin-en-Yvelines, UMR 1181, Biostatistics, B2PHI, Montigny-le-Bretonneux, France AP-HP, Raymond Poincare Hospital, Garches, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Guillemot
authors.affiliation: Inserm UMR 1181, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), Paris, France Institut Pasteur, UMR 1181, B2PHI, Paris, France University Versailles St-Quentin-en-Yvelines, UMR 1181, Biostatistics, B2PHI, Montigny-le-Bretonneux, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Delarocque-Astagneau
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000635:transmission*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008270:Madagascar; D011247:Pregnancy; D055815:Young Adult; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1
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