title: Reduced Expression of miR-23a Suppresses A20 in TLR-stimulated Macrophages.
abstract: High levels of miR-23a expression in human primary macrophages suggested that miR-23a might have an important role in innate immune cells. Therefore, we investigated whether miR-23a regulates the secretion of cytokines by immune cells. Herein, we demonstrate that the expression of miR-23a was reduced in toll-like receptor (TLR)-stimulated macrophages. By targeting A20, miR-23a could affect NF-κB activity and the expression of downstream NF-κB-target genes that encode proinflammatory mediators, such as IL-6 and TNF-α. In summary, our study describes a novel role for miR-23a in the regulation of inflammatory cytokine production in macrophages, which could yield new insights into the regulatory role of miRNAs in the inflammatory response.
authors.affiliation: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1, ShaiFuYuan, Dongcheng District, Beijing, China, 100730.
authors.forename: Ping
authors.initials: P
authors.lastname: Peng
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Li
authors.forename: Xinyan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D002460:Cell Line; D003546:Cysteine Endopeptidases / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000235:genetics; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D051193:Toll-Like Receptors / Q000378:metabolism*; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
chemical_list: D018836:Inflammation Mediators; D047908:Intracellular Signaling Peptides and Proteins; D035683:MicroRNAs; C534062:Mirn23b microRNA, mouse; D051193:Toll-Like Receptors; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D003546:Cysteine Endopeptidases; C513261:Tnfaip3 protein, mouse
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