title: Mycosis fungoides: Positron emission tomography/computed tomography in staging and monitoring the effect of therapy.
abstract: A 58-year-old woman, diagnosed as a case of mycosis fungoides (MF), underwent [18F]-fluoro-D-glucose positron emission tomography/computed tomography (FDG PET/CT) examination. The study revealed intense FDG uptake in a large ulceroproliferative right thigh lesion, indurated plaques in the chest wall and left thigh, along with multiple sites of cutaneous involvement, axillary and inguinal lymphadenopathy. The patient underwent chemotherapy with CHOP regimen, radiotherapy for the right thigh lesion, along with topical corticosteroids and emollients for the disseminated cutaneous involvement. Repeat [18F]-FDG PET/CT study performed a year later, showed near complete disease regression specifically of the ulceroproliferative lesion and indurated cutaneous plaques, no change in lymphadenopathy, and a subtle diffuse progression of the remaining cutaneous lesions. A multidisciplinary approach to the diagnosis, staging and treatment of MF has long been suggested for optimizing outcomes from management of patients with this disease. This case highlights the potential role of incorporating PET/CT as a single modality imaging technique in the staging and assessment of response to therapy.
authors.affiliation: Division of PET Imaging, Division of PET Imaging, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Maria Mathew
authors.initials: MM
authors.lastname: D'Souza
authors.affiliation: Department of Dermatology and Venereology, ESI Post Graduate Institute of Medical Education and Research, New Delhi, India.
authors.forename: Paschal
authors.initials: P
authors.lastname: D'Souza
authors.affiliation: Division of PET Imaging, Division of PET Imaging, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Rajnish
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Division of PET Imaging, Division of PET Imaging, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Abhinav
authors.initials: A
authors.lastname: Jaimini
authors.affiliation: Division of PET Imaging, Division of PET Imaging, Molecular Imaging and Research Centre, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Mondal
keywords: [18F]-fluoro-D-glucose positron emission tomography/computed tomography; mycosis fungoides; staging
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