title: Dextrin-coated zinc substituted cobalt-ferrite nanoparticles as an MRI contrast agent: In vitro and in vivo imaging studies.
abstract: Application of superparamagnetic iron oxide nanoparticles (NPs) as a negative contrast agent in magnetic resonance imaging (MRI) has been of widespread interest. These particles can enhance contrast of images by altering the relaxation times of the water protons. In this study, dextrin-coated zinc substituted cobalt-ferrite (Zn0.5Co0.5Fe2O4) NPs were synthesized by a co-precipitation method, and the morphology, size, structure and magnetic properties of the NPs were investigated. These NPs had superparamagnetic behavior with an average size of 3.9 (±0.9, n=200)nm measured by transmission electron microscopy. Measurements on the relaxivities (r2 and r2(*)) of the NPs were performed in vitro by agarose phantom. In addition, after subcutaneous injection of the NPs into C540 cell line in C-57 inbred mice, the relaxivities were measured in vivo by a 1.5T MRI system. These NPs could effectively increase the image contrast in both T2-and T2(*)-weighted samples.
authors.affiliation: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Sattarahmady
authors.affiliation: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: T
authors.initials: T
authors.lastname: Zare
authors.affiliation: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Mehdizadeh
authors.affiliation: Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Azarpira
authors.affiliation: Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Heidari
authors.affiliation: Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Lotfi
authors.affiliation: Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: heli@sums.ac.ir.
authors.forename: H
authors.initials: H
authors.lastname: Heli
mesh_terms: D000818:Animals; D003035:Cobalt / Q000737:chemistry*; D003287:Contrast Media / Q000493:pharmacokinetics*; D003912:Dextrins / Q000737:chemistry*; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D046529:Microscopy, Electron, Transmission; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D010316:Particle Size; D019047:Phantoms, Imaging; D011522:Protons; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays; D015032:Zinc / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D003912:Dextrins; D005290:Ferric Compounds; D011522:Protons; C001215:ferrite; D003035:Cobalt; D015032:Zinc
keywords: Contrast agent; MRI; Relaxivity; Superparamagnetic nanoparticles; Zinc substituted cobalt ferrite