title: Seroprevalence of transfusion transmissible infections (TTI), in first time blood donors in Abeokuta, Nigeria.
abstract: BACKGROUND
  Transfusion transmissible infections, such as HIV, HBV, HCV and syphilis are on the rise and pose a threat to blood safety.
  
  
  OBJECTIVE
  To determine prevalence and demographic profiles of TTI's among first time blood donors in Abeokuta, Nigeria.
  
  
  METHODS
  The study was conducted between February to November 2013; 130 first time blood donors were tested for the presence of HIV, HBsAg, HCV antibodies and Treponema palidium antibodies using EIA based rapid immunochromatographic kits. Data analysis was done using SPSS with a level of significance of p<0.05.
  
  
  RESULTS
  Prevalence rates to HIV, HBsAg, HCV antibody, were 6.2% (n=8), 10% (n=13) and 1.5% (n=2), there was 0% prevalence to Treponema palidium antibodies. Group specific prevalence rates revealed that educational status was associated with HBsAg positivity (p = 0.028), donors with a history of previous blood transfusion was also statistically associated with HIV sero-reactivity (p = 0.013).
  
  
  CONCLUSIONS
  High levels of HBsAg and HIV were observed, there is need to revise the donor testing algorithm in Nigeria in line with the prevalence of TTI's. We also advocate that a National surveillance system for TTI's be established through our National blood transfusion service (NBTS) program, a second serological test is also suggested to reduce the risk of occult HBV infection in Nigeria.
authors.affiliation: Microbiology Unit, Pathology department, Federal Medical Centre, Abeokuta ; Department of Virology, College of Medicine, University of Ibadan.
authors.forename: Babatunde Olanrewaju
authors.initials: BO
authors.lastname: Motayo
authors.affiliation: Department of Virology, College of Medicine, University of Ibadan.
authors.forename: Adedayo Omotayo
authors.initials: AO
authors.lastname: Faneye
authors.affiliation: Hematology and Blood Transfusion Unit, Pathology department, Federal Medical Centre, Abeokuta.
authors.forename: Usen Asuquo
authors.initials: UA
authors.lastname: Udo
authors.affiliation: Department of Virology, College of Medicine, University of Ibadan.
authors.forename: Babatunde Adebiyi
authors.initials: BA
authors.lastname: Olusola
authors.affiliation: Microbiology Unit, Pathology department, Federal Medical Centre, Abeokuta ; Hematology and Blood Transfusion Unit, Pathology department, Federal Medical Centre, Abeokuta.
authors.forename: Isreal
authors.initials: I
authors.lastname: Ezeani
authors.affiliation: Microbiology Unit, Pathology department, Federal Medical Centre, Abeokuta.
authors.forename: Joseph Iruobe
authors.initials: JI
authors.lastname: Ogiogwa
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D017848:Blood-Borne Pathogens / Q000302:isolation & purification*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D018937:Hepatitis C Antibodies / Q000097:blood / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D013587:Syphilis / Q000097:blood / Q000453:epidemiology* / Q000635:transmission; D065227:Transfusion Reaction
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies
keywords: Blood donors; Nigeria; Prevalence rate; TTI's
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