title: Eight challenges in modelling disease ecology in multi-host, multi-agent systems.
abstract: Many disease systems exhibit complexities not captured by current theoretical and empirical work. In particular, systems with multiple host species and multiple infectious agents (i.e., multi-host, multi-agent systems) require novel methods to extend the wealth of knowledge acquired studying primarily single-host, single-agent systems. We outline eight challenges in multi-host, multi-agent systems that could substantively increase our knowledge of the drivers and broader ecosystem effects of infectious disease dynamics.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California-Los Angeles, Los Angeles, CA, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA. Electronic address: michael.buhnerkempe@ucla.edu.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Buhnerkempe
authors.affiliation: Institute of Natural & Mathematical Sciences, New Zealand Institute for Advanced Study and Infectious Disease Research Centre, Massey University, Auckland, New Zealand.
authors.forename: Mick G
authors.initials: MG
authors.lastname: Roberts
authors.affiliation: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA; Santa Fe Institute, Santa Fe, NM, USA.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Dobson
authors.affiliation: Faculty of Veterinary Medicine, University of Utrecht, Utrecht, Netherlands.
authors.forename: Hans
authors.initials: H
authors.lastname: Heesterbeek
authors.affiliation: Fogarty International Center, National Institutes of Health, Bethesda, MD, USA; Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA; The Huck Institute for Life Sciences, Pennsylvania State University, University Park, PA, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hudson
authors.affiliation: Department of Ecology and Evolutionary Biology, University of California-Los Angeles, Los Angeles, CA, USA; Fogarty International Center, National Institutes of Health, Bethesda, MD, USA.
authors.forename: James O
authors.initials: JO
authors.lastname: Lloyd-Smith
mesh_terms: D003141:Communicable Diseases / Q000453:epidemiology* / Q000635:transmission; D004463:Ecology; D020387:Food Chain; D054884:Host-Pathogen Interactions; D006801:Humans; D008018:Life Cycle Stages; D015233:Models, Statistical; D011157:Population Dynamics
keywords: Community ecology; Food webs; Maintenance; Multiple hosts; Multiple pathogens
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