title: The role of selectins in alopecia areata.
abstract: BACKGROUND
  One of the main histopathological features of alopecia areata (AA) is a lymphocytic infiltration that surrounds hair follicles. Soluble forms of E, L, P-selectins are known indicators of ongoing inflammation. There are no studies regarding the assessment of their contribution in AA.
  
  
  OBJECTIVE
  To assess serum concentrations of selectins (E-selectin, L-selectin and P-selectin) in patients with AA in relation to selected clinical parameters, including disease severity and activity.
  
  
  METHODS
  Sixty-four patients with AA were involved in the study. The diagnosis was based on physical examination and photodermoscopy. The control group consisted of 40 healthy subjects. The serum concentrations of soluble E-selectin, L-selectin and P-selectin were detected with ELISA method.
  
  
  RESULTS
  Statistically significantly higher levels of E, P, L-selectins were found in AA patients as compared with the healthy group. Serum concentrations of soluble forms of E- and L-selectins correlated with the severity of the disease, while E-selectin with activity of AA.
  
  
  CONCLUSIONS
  This study shows that selectins may play an important role in the pathogenesis of AA and may be a target of future therapies in this disease.
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
authors.forename: Wiesława
authors.initials: W
authors.lastname: Sudnik
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dańczak-Pazdrowska
authors.affiliation: Great Poland Center of Allergology and Aesthetic Dermatology "Art Clinic", Poznan, Poland. Head of Center: Prof. Wojciech Silny MD, PhD.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Silny
authors.affiliation: Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Osmola-Mańkowska
authors.affiliation: Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Wojciech Golusiński MD, PhD.
authors.forename: Jakub
authors.initials: J
authors.lastname: Pazdrowski
authors.affiliation: Department of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ryszard Żaba MD, PhD.
authors.forename: Adriana
authors.initials: A
authors.lastname: Polańska
keywords: E-selectin; L-selectin; P-selectin; alopecia areata
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