title: Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome.
abstract: Repetitive elements (REs) make up the vast majority of the mammalian genomes. We identified species-specific genomic libraries of RE arrays. The non-random configurations of RE arrays suggest their functions. We tested whether RE arrays undergo age- and tissue/cell-specific rearrangements. An RE array of C57BL/6J mice, containing tandem repeats of a mosaic of transposable REs, was selected to examine rearrangements in different ages and tissues. There were marked changes in the array configuration in the genomes of the skin and brain in all mice of six weeks and older, whereas the heart and liver had alterations at 29weeks. The temporal variations were confirmed by identifying putative rearrangement junctions. Temporal and spatial rearrangements of certain RE arrays may contribute to the acquired characteristics of the genome information system.
authors.affiliation: Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
authors.forename: Kang-Hoon
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Yee
authors.affiliation: Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
authors.forename: Debora
authors.initials: D
authors.lastname: Lim
authors.affiliation: Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA.
authors.forename: David
authors.initials: D
authors.lastname: Greenhalgh
authors.affiliation: Department of Surgery, University of California, Davis and Shriners Hospitals for Children Northern California, Sacramento, CA 95817, USA. Electronic address: kcho@ucdavis.edu.
authors.forename: Kiho
authors.initials: K
authors.lastname: Cho
mesh_terms: D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D016678:Genome; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012867:Skin / Q000254:growth & development / Q000378:metabolism*; D013045:Species Specificity
keywords: Acquired genome characteristics; Dynamic genome; Four-dimensional genome unit; RE array(CHR7.32); Spatial rearrangement; Temporal rearrangement
references.citation: PLoS One. 2014;9(7):e97984
references.pmid: 24988390
references.citation: PLoS One. 2012;7(4):e35156
references.pmid: 22529984
references.citation: Curr Genomics. 2010 Apr;11(2):115-28
references.pmid: 20885819
references.citation: J Virol. 2005 Oct;79(19):12507-14
references.pmid: 16160178
references.citation: Nature. 2004 Oct 21;431(7011):931-45
references.pmid: 15496913
references.citation: Chromosome Res. 2013 Mar;21(1):15-26
references.pmid: 23359013
references.citation: Cell. 2013 Mar 28;153(1):101-11
references.pmid: 23540693
references.citation: Genomics. 2012 Sep;100(3):131-40
references.pmid: 22750555
references.citation: Shock. 2008 Aug;30(2):105-16
references.pmid: 18317406
references.citation: Retrovirology. 2014;11:59
references.pmid: 25063042
references.citation: Exp Mol Pathol. 2012 Aug;93(1):167-72
references.pmid: 22548960
references.citation: Genome Res. 2002 Oct;12(10):1455-65
references.pmid: 12368238
references.citation: Genomics. 2011 Nov;98(5):381-9
references.pmid: 21803149
references.citation: Nature. 2002 Dec 5;420(6915):520-62
references.pmid: 12466850
references.citation: Exp Mol Pathol. 2014 Apr;96(2):178-87
references.pmid: 24509167
references.citation: BMC Immunol. 2013;14:2
references.pmid: 23289855
references.citation: Shock. 2009 Jul;32(1):80-8
references.pmid: 18948849
references.citation: Exp Mol Pathol. 2011 Jun;90(3):300-11
references.pmid: 21376035
references.citation: Nature. 2001 Feb 15;409(6822):860-921
references.pmid: 11237011