title: Favorable effects of superficially deacetylated chitin nanofibrils on the wound healing process.
abstract: Previous reports indicate that the beneficial effect of chitin nanofibrils (CNFs), and chitosan nanofibrils (CSNFs) for wound healing. In this study, the wound healing effects of superficially deacetylated chitin nanofibrils (SDACNFs) were evaluated using an experimental model. In the experiments using circular excision wound model, SDACNFs induced re-epithelium and proliferation of the fibroblasts and collagen tissue. In the chitin, CNFs, and CSNFs, on the other hand, the e-epithelium and proliferation of the fibroblasts and collagen tissue were not induced perfectly compared with the SDACNFs group. In particular, re-epithelization was observed on day 4 in the only SDACNF group. Moreover, SDACNFs did not induce severe systemic inflammation in the linear incision wound model. The data indicated that SDACNFs effectively induced the proliferation and re-modeling phases compared with chitin, CNFs, and CSNFs in the wound. These data indicate that SDACNFs can be beneficial as a new biomaterial for wound healing.
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Izumi
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Komada
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Ochi
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Lisa
authors.initials: L
authors.lastname: Karasawa
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Murahata
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tsuka
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Imagawa
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Itoh
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Izawa
authors.affiliation: Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Morimoto
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saimoto
authors.affiliation: Department of Veterinary Clinical Medicine, Tottori University, Tottori 680-8533, Japan. Electronic address: kazu-azuma@muses.tottori-u.ac.jp.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Graduate School of Engineering, Tottori University, Tottori 680-8533, Japan. Electronic address: sifuku@chem.tottori-u.ac.jp.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ifuku
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002686:Chitin / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D057139:Nanofibers / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D002686:Chitin
keywords: Biomaterials; Chitin nanofibrils; Re-epithelium; Superficially deacetylated chitin nanofibrils; Wound healing