title: Effect of hyperbaric oxygen therapy on amphotericin-B induced acute renal failure in rats.
abstract: OBJECTIVE
  Acute renal injury may occur after amphotericin B (AmB) administration. The hypothesized injury mechanism is renal vasoconstriction and direct toxic damage. Hyperbaric oxygen therapy (HBO) is indicated for treatment of many ischemic events but not for acute renal failure (ARF). The aim of this study was to investigate the role of HBO therapy in AmB induced ARF.
  
  
  METHODS
  ARF was induced in 41 Sprague-Dawley rats by a single dose of 75 mg/kg AmB. The rats were randomly divided into two groups; one group was treated with daily HBO for 3 consecutive days. The control group received no HBO treatment. Parameters of renal function were taken on the 5th day after AmB administration.
  
  
  RESULTS
  Forty-one rats were treated with AmB, 21 received HBO and 20 served as controls. Body weight loss following the administration of AmB was 13.5+14.7% in the HBO treated rats, as opposed to 24.6+5% in the control group (P=0.004). Serum creatinine and urea were 0.49+0.13 mg/dL and 200.63+87.82 mg/dL in the treatment group and 0.70+0.22 mg/dL and 368.01+169.35 mg/dL, respectively in the control (P=0.001).
  
  
  CONCLUSIONS
  In this model of AmB-induced ARF, HBO treatment alleviated renal injury as reflected by changes in serum creatinine and urea levels.
authors.affiliation: Pediatric Division, Assaf Harofeh Medical Center Zerifin 70300, Sackler Faculty of Medicine Tel Aviv University, Israel - abukishk_i@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Nir
authors.forename: M
authors.initials: M
authors.lastname: Berkovitch
authors.forename: I
authors.initials: I
authors.lastname: Youngster
authors.forename: E
authors.initials: E
authors.lastname: Kozer
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: I
authors.initials: I
authors.lastname: Abu-Kishk
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000666:Amphotericin B; D000818:Animals; D000900:Anti-Bacterial Agents; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D006931:Hyperbaric Oxygenation / Q000379:methods; D007677:Kidney Function Tests; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000097:blood; D015431:Weight Loss / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D000666:Amphotericin B; D014508:Urea; D003404:Creatinine