title: A genetic variant in CHRNB3-CHRNA6 increases risk of esophageal squamous cell carcinoma in Chinese populations.
abstract: Nicotinic acetylcholine receptors are important regulators of smoking behavior and tobacco carcinogenesis. We studied the association of the CHRNB3-A6 variant rs13280604 in relation to esophageal squamous cell carcinoma (ESCC) in Chinese populations. Two independent case-control studies were conducted. The first case-control study, consisted of 866 ESCC patients and 1621 healthy controls from Northern China, and the second case-control study consisted of 853 ESCC patients and 860 unrelated controls from Southern China. A logistic regression model was used to evaluate the associations of rs13280604 with cancer risk. We found that Rs13280604 GG/AG genotypes were significantly associated with increased risk for ESCC in both case-control studies from Northern [odds ratio (OR), 1.42, 95% confidence interval (CI), 1.19-1.70, P = 1.1×10(-4)], Southern China (OR, 1.56, 95% CI, 1.26-1.93, P = 5.2×10(-5)), and the combined population of both studies (OR, 1.44, 95% CI, 1.26-1.65, P = 8.7×10(-8)), respectively. Our results suggest that this CHRNB3-A6 variant confers susceptibility to ESCC risk. However, future larger studies are needed to validate our finding.
authors.affiliation: Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong Province, China.
authors.forename: Yipeng
authors.initials: Y
authors.lastname: Song
authors.affiliation: Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong Province, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Head and Neck Surgery, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.affiliation: Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong Province, China.
authors.forename: Jinbo
authors.initials: J
authors.lastname: Ma
authors.affiliation: Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong Province, China.
authors.forename: Ercheng
authors.initials: E
authors.lastname: Chen
authors.affiliation: Radiation Oncology Department, Affiliated Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong Province, China.
authors.forename: Rukun
authors.initials: R
authors.lastname: Zang
authors.affiliation: Key Laboratory of Oncology in Southern China and Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong Province, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jia
authors.affiliation: Radiology Department, Shanghai Ninth People's Hospital Affiliated Shanghai Jiaotong University School of Medicine, Shanghai, China, cjr.taoxiaofeng@vip.163.com.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Tao
authors.affiliation: Radiation Oncology Department, Qilu Hospital, Shandong University, Jinan, Shandong Province, China cjr.taoxiaofeng@vip.163.com hlk8868@yahoo.com.
authors.forename: Likuan
authors.initials: L
authors.lastname: Hu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012372:ROC Curve; D011978:Receptors, Nicotinic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; C470410:CHRNA6 protein, human; C539371:CHRNB3 protein, human; D011978:Receptors, Nicotinic