title: Peritumoral dermis of squamous cell carcinomas in renal transplant recipients contains less CD11c+ myeloid dendritic cells and FoxP3+ T cells compared to immunocompetent controls.
abstract: BACKGROUND
  Renal transplant recipients (RTR) have an increased risk of developing cutaneous squamous cell carcinomas (SCC). These SCC are often more aggressive than SCC in immunocompetent individuals.
  
  
  OBJECTIVE
  In this comparative study, we analysed the cell composition in the tissue immediately surrounding invasive SCC in immunosuppressed RTR and immunocompetent controls in an effort to further elucidate the role of the local immune system.
  
  
  METHODS
  Morphology and quantity of various dendritic cell (DC) subsets, macrophages and FoxP3+ T cells were analysed by immunohistochemical staining.
  
  
  RESULTS
  The number of CD11c+ myeloid DC and FoxP3+ T cells was significantly reduced in RTR, whereas the number of plasmacytoid DC, Langerhans cells and macrophages was similar in RTR and controls.
  
  
  CONCLUSIONS
  A reduction in CD11c+ mDC in peritumoral dermis in RTR might contribute to impaired immunosurveillance thus giving rise to an increased risk to develop aggressive SCC in these patients.
authors.affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.|Department of Dermatology, Haukeland University Hospital, Bergen, Norway.
authors.forename: L F
authors.initials: LF
authors.lastname: Sandvik
authors.affiliation: Section for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Skarstein
authors.affiliation: Department of Pathology and Cytology, Karolinska University Laboratories, Stockholm, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Krynitz
authors.affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Volchenkov
authors.affiliation: Section for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.|Department of Pathology, Haukeland University Hospital, Bergen, Norway.
authors.forename: L
authors.initials: L
authors.lastname: Sviland
authors.affiliation: The Norwegian Renal Registry, Department of Transplantation Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Leivestad
authors.affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Jonsson
authors.affiliation: Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Appel
mesh_terms: D000368:Aged; D039521:CD11c Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000276:immunology*; D003713:Dendritic Cells / Q000737:chemistry / Q000276:immunology*; D020405:Dermis / Q000276:immunology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000032:analysis; D006801:Humans; D007121:Immunocompetence; D007157:Immunologic Surveillance; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation; D007801:Langerhans Cells / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*
chemical_list: D039521:CD11c Antigen; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors