title: Hypertension in Older Persons: A Systematic Review of National and International Treatment Guidelines.
abstract: Despite good evidence regarding the benefits of managing hypertension in elderly populations, the extent to which this evidence has been incorporated into national and international clinical hypertension treatment guidelines is unknown. A systematic review was conducted to identify recommendations in current national and international hypertension treatment guidelines with a focus on specific targets and treatment recommendations for older persons with uncomplicated hypertension. Guidelines for the management of hypertension published or updated over a 5-year period (2009-2014) were identified by searching Medline, Google, and Google Scholar. Thirteen guidelines that met the predefined inclusion criteria were included in the review. Among these guidelines was considerable variation regarding who is considered an older person. However, there was general consensus regarding blood pressure targets. While current hypertension guidelines do include recommendations regarding management of uncomplicated hypertension in older populations, the depth and breadth of these recommendations vary considerably between guidelines and may limit the usefulness of such treatment guidelines to clinicians.
authors.affiliation: From the Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.|College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Tariq M
authors.initials: TM
authors.lastname: Alhawassi
authors.affiliation: From the Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
authors.forename: Ines
authors.initials: I
authors.lastname: Krass
authors.affiliation: Australian Institute of Health Innovation, Macquarie University, NSW, Australia.
authors.forename: Lisa G
authors.identifier: http://orcid.org/0000-0002-8545-716X
authors.initials: LG
authors.lastname: Pont
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination / Q000592:standards; D002986:Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017410:Practice Guidelines as Topic / Q000592:standards
chemical_list: D000959:Antihypertensive Agents
references.citation: J Am Coll Cardiol. 2011 May 17;57(20):2037-114
references.pmid: 21524875
references.citation: J Hypertens. 2014 Mar;32(3):454-63
references.pmid: 24384846
references.citation: JAMA. 1995 May 3;273(17):1348-53
references.pmid: 7715059
references.citation: BMJ. 2008 May 17;336(7653):1121-3
references.pmid: 18480116
references.citation: JAMA. 1991 Jun 26;265(24):3255-64
references.pmid: 2046107
references.citation: CMAJ. 2006 Jun 6;174(12):1737-42
references.pmid: 16754904
references.citation: JAMA. 2005 Jul 27;294(4):466-72
references.pmid: 16046653
references.citation: N Engl J Med. 2008 May 1;358(18):1887-98
references.pmid: 18378519
references.citation: Ethn Dis. 1999 Autumn;9(3):333-40
references.pmid: 10600055
references.citation: Stroke. 1989 Jan;20(1):4-13
references.pmid: 2911834
references.citation: Lancet. 2014 May 31;383(9932):1861
references.pmid: 24881973
references.citation: Hypertens Res. 2008 Dec;31(12):2115-27
references.pmid: 19139601
references.citation: PLoS One. 2013;8(1):e53744
references.pmid: 23349738
references.citation: Lancet. 1997 Sep 13;350(9080):757-64
references.pmid: 9297994
references.citation: Eur Heart J. 2013 Jul;34(28):2159-219
references.pmid: 23771844
references.citation: Swiss Med Wkly. 2012 May 09;142:w13574
references.pmid: 22573500
references.citation: J Clin Hypertens (Greenwich). 2014 Apr;16(4):241-5
references.pmid: 24666403
references.citation: JAMA. 1998 Jun 17;279(23):1903-7
references.pmid: 9634263
references.citation: JAMA. 2014 Feb 5;311(5):507-20
references.pmid: 24352797
references.citation: Blood Press. 1996 Sep;5(5):300-4
references.pmid: 8879603
references.citation: Am J Med. 2004 Jul 1;117(1):14-8
references.pmid: 15210383
references.citation: Nat Rev Cardiol. 2012 Mar 13;9(5):286-96
references.pmid: 22411292
references.citation: J Hypertens. 1986 Aug;4(4):511-3
references.pmid: 3534088
references.citation: Can Fam Physician. 2011 Jul;57(7):e253-62
references.pmid: 21753084
references.citation: Can Fam Physician. 2013 Jan;59(1):19-21, 22-4
references.pmid: 23341648
references.citation: S Afr Med J. 2011 Dec 14;102(1 Pt 2):57-83
references.pmid: 22273141
references.citation: Hypertens Res. 2014 Apr;37(4):253-390
references.pmid: 24705419
references.citation: Drugs. 2014 Nov;74(17):2033-51
references.pmid: 25315030
references.citation: J Hum Hypertens. 1991 Dec;5(6):469-74
references.pmid: 1791605
references.citation: Hypertens Res. 2004 Sep;27(9):657-61
references.pmid: 15750259
references.citation: JAMA. 2003 May 21;289(19):2560-72
references.pmid: 12748199
references.citation: Can J Cardiol. 2014 May;30(5):485-501
references.pmid: 24786438
references.citation: Drug Healthc Patient Saf. 2013 Jun 24;5:143-50
references.pmid: 23843704
references.citation: Cochrane Database Syst Rev. 2009 Oct 07;(4):CD000028
references.pmid: 19821263
references.citation: J Formos Med Assoc. 2010 Oct;109(10):740-73
references.pmid: 20970072
references.citation: Lancet. 1993 Nov 27;342(8883):1317-22
references.pmid: 7901634
references.citation: J Hypertens. 2009 May;27(5):905-22
references.pmid: 19349909
references.citation: Nat Rev Endocrinol. 2013 Apr;9(4):189-90
references.pmid: 23381036
references.citation: J Clin Hypertens (Greenwich). 2014 Jan;16(1):14-26
references.pmid: 24341872