title: (13)C and (15)N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes.
abstract: (13)C and (15)N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
authors.affiliation: CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
authors.forename: M João G
authors.initials: MJ
authors.lastname: Ferreira
authors.affiliation: IQUIR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Área Técnica Farmacéutica, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: García
authors.affiliation: IQUIR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Área Técnica Farmacéutica, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Leonardi
authors.affiliation: IQUIR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Área Técnica Farmacéutica, Universidad Nacional de Rosario, Rosario, Argentina.
authors.forename: Claudio J
authors.initials: CJ
authors.lastname: Salomon
authors.affiliation: IQUIR-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Área Técnica Farmacéutica, Universidad Nacional de Rosario, Rosario, Argentina. Electronic address: mlamas@fbioyf.unr.edu.ar.
authors.forename: M Celina
authors.initials: MC
authors.lastname: Lamas
authors.affiliation: CQE, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. Electronic address: teresa.nunes@ist.utl.pt.
authors.forename: Teresa G
authors.initials: TG
authors.lastname: Nunes
mesh_terms: D015766:Albendazole / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D033362:Powder Diffraction; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D003505:Cyclodextrins; D015766:Albendazole
keywords: Albendazole; Cyclodextrin; Inclusion complex; Solid-state NMR