title: Differential expression of hypertension-associated microRNAs in the plasma of patients with white coat hypertension.
abstract: White coat hypertension (WCH) is a high cardiovascular risk condition, and a fundamental understanding of the cause and pathophysiology of the disorder is still lacking. Recent studies demonstrated that microRNAs (miRNAs) are involved in hypertension; however, the roles of miRNAs in WCH are not known. The expressions of selected 10 miRNAs were investigated independently in plasma samples from 30 hypertension (HT) patients, 30 WCH patients, and 30 normotensive (NT) subjects. MiR-21, miR-122, miR-637, and let-7e expression levels were significantly upregulated in the HT group compared with the NT groups (P = 0.017, P = 0.022, P = 0.048, and P = 0.013, respectively). MiR-122 and miR-637 expressions were also significantly upregulated in the WCH group compared with the NT group (P = 0.048 and P = 0.039, respectively). MiR-296-5p expression level was significantly downregulated in HT patients and upregulated in the WCH patients compared with the NT group (P = 0.049 and P = 0.039, respectively). Additionally, the ambulatory 24-hour and daytime systolic and diastolic blood pressures were negatively correlated with miR-296-5p. MiR-296 and miR-637 had area under the curve (AUC) values of 0.778 and 0.774, respectively, which demonstrates their sufficiency to distinguish WCH from NT individuals. MiR-296 and miR-637 had AUC values of 0.868 and 0.680, respectively, which shows their potential to distinguish WCH from HT individuals. We report for the first time a plasma miRNA profile for WCH patients and demonstrate a novel link between miRNA and WCH. These findings may reveal crucial insights into the development of WCH.
authors.affiliation: From the Department of Internal Medicine (MC, SY, CA, HY, YK), Cerrahpasa Medical School, Istanbul University; Department of Medical Genetics (OFK, E Koparir, E Kirat, MO), Istanbul University Cerrahpasa Medical School, Istanbul; Molecular Biology and Genetics Department (OFK), Erzurum Technical University, Erzurum, Turkey; Department of Pathology & Immunology (MO), Baylor College of Medicine, Houston, Texas; and Department of Molecular Biology and Genetics (MO), Biruni University, Istanbul, Turkey.
authors.forename: Mahir
authors.initials: M
authors.lastname: Cengiz
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Karatas
authors.forename: Erkan
authors.initials: E
authors.lastname: Koparir
authors.forename: Serap
authors.initials: S
authors.lastname: Yavuzer
authors.forename: Chayar
authors.initials: C
authors.lastname: Ali
authors.forename: Hakan
authors.initials: H
authors.lastname: Yavuzer
authors.forename: Emre
authors.initials: E
authors.lastname: Kirat
authors.forename: Yesari
authors.initials: Y
authors.lastname: Karter
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015854:Up-Regulation; D059466:White Coat Hypertension / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
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