title: [Management of side effects of targeted therapies in renal cancer: nephrological side effects].
abstract: Several types of nephrological side-effects can occur during treatment with targeted therapy: high blood pressure, proteinuria, thrombotic microangiopathy, kidney failure, etc. Screening and treatment for high blood pressure, proteinuria and kidney failure are recommended during treatment with molecular targeted therapy (mainly for anti-VEGF). If BP is greater than 140/90mmHg on two measurements, it must be treated before the start of treatment. Self-measurement or ambulatory measurement of blood pressure is recommended. All antihypertensive drugs may be used apart from those, which interfere with cytochrome P450 (verapamil and diltiazem). Specialist advice (cardiology or nephrology) is recommended in the event of uncontroled hypertension. It is essential to monitor proteinuria with a urine strip test: if proteinuria is less than 2+ (grade 1), maintain treatment with molecular targeted therapy; if proteinuria is greater or equal to 2+ (grade2 or 3, confirmed by weight assay), specialist advice is required. Persisting proteinuria of grade2 or 3 requires nephrological monitoring. Thrombotic microangiopathy must be investigated in the event of hypertension greater than grade2 and/or proteinuria greater than 2+.
authors.affiliation: CHU de la Pitié-Salpêtrière, service de néphrologie, 47-83, boulevard de l'Hôpital, 75651 Paris Cedex 13, France. Electronic address: hassan.izzedine@psl.aphp.fr.
authors.forename: Hassan
authors.initials: H
authors.lastname: Izzedine
authors.affiliation: Centre Léon-Bérard, service d'oncologie médicale, 28, rue Laennec, 69373 Lyon Cedex 8, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Négrier
authors.affiliation: Hôpital Foch, service d'urologie, 40, rue Worth, BP 36, 92151 Suresnes Cedex, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Neuzillet
authors.affiliation: CHRU de Lille, service d'urologie, Lille, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Zini
keywords: hypertension (high blood pressure); hypertension artérielle; insuffisance rénale; kidney failure; micro-angiopathie thrombotique; proteinuria; protéinurie; thrombotic microangiopathy