title: Multiple Pathology in a Single Lesion: AOT Associated with Dentigerous Cyst.
abstract: Odontogenic cysts and tumors are quite common occurrences in jaw bones, although both of them occurring together are rare. The epithelial lining of odontogenic cyst has a potential to transform into neoplastic conditions like squamous cell carcinoma and mucoepidermoid carcinoma, and odontogenic tumors like ameloblastoma and adenomatoid odontogenic tumor. However, the frequency of such cases being encountered is very less. Here, we report a case of adenomatoid odontogenic tumor (AOT) associated with a dentigerous cyst around the crown of an unerupted lateral incisor (follicular variant), in a 14-year-old boy. We also attempt to unravel its mechanism of cytodifferentiation and tumor progression. The origin and nature of such kind of lesions (i.e., independent development of multiple pathologies as a single lesion in a single location, single pathology giving rise to another pathology or a distinct entity/new variant) cannot be explained with certainty at this point of time. The molecular mechanism of tumor development needs to be further elucidated in order to conclude that a different entity called 'hybrid' AOT exists.
authors.affiliation: Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, MNR Nagar, Fasalwadi, Sangareddy 502294 India.
authors.forename: S
authors.initials: S
authors.lastname: Durga Sreenivas
authors.affiliation: Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, MNR Nagar, Fasalwadi, Sangareddy 502294 India.
authors.forename: C
authors.initials: C
authors.lastname: Sree Lalita
authors.affiliation: Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, MNR Nagar, Fasalwadi, Sangareddy 502294 India.
authors.forename: G
authors.initials: G
authors.lastname: Harsha
authors.affiliation: Department of Oral and Maxillofacial Surgery, MNR Dental College and Hospital, MNR Nagar, Fasalwadi, Sangareddy 502294 India.
authors.forename: C Venkateshwara
authors.initials: CV
authors.lastname: Rao
keywords: Adenomatoid odontogenic tumor; Dentigerous cyst; Multiple pathology; Pathogenesis
references.citation: J Oral Pathol Med. 1996 May;25(5):249-55
references.pmid: 8835823
references.citation: J Oral Maxillofac Surg. 1992 Feb;50(2):190-3
references.pmid: 1732497
references.citation: Oral Oncol. 2006 Apr;42(4):398-408
references.pmid: 16376138
references.citation: Acta Pathol Microbiol Scand. 1969;75(3):375-98
references.pmid: 5801660
references.citation: Oral Surg Oral Med Oral Pathol. 1948 Oct;1(10):887-94
references.pmid: 18888040
references.citation: J Oral Pathol Med. 1992 Sep;21(8):348-52
references.pmid: 1403843
references.citation: J Oral Maxillofac Surg. 1996 May;54(5):634-7
references.pmid: 8632252
references.citation: J Philipp Dent Assoc. 1988 Dec-1989 Jan;41(3):35-41
references.pmid: 3271867
references.citation: Int J Pediatr Otorhinolaryngol. 2005 Dec;69(12):1685-8
references.pmid: 15996761
references.citation: J Maxillofac Oral Surg. 2015 Jun;14(2):393-7
references.pmid: 26028864
references.citation: Med Oral Patol Oral Cir Bucal. 2010 Sep 01;15(5):e709-15
references.pmid: 20383104
references.citation: Cancer. 1990 Aug 15;66(4):786-8
references.pmid: 2201428
references.citation: Oral Oncol. 1999 Mar;35(2):125-31
references.pmid: 10435145
references.citation: J Oral Pathol Med. 1991 Apr;20(4):149-58
references.pmid: 2061853
references.citation: Braz J Otorhinolaryngol. 2007 Jan-Feb;73(1):129-31
references.pmid: 17505612
references.citation: Cell. 1989 Jun 30;57(7):1083-93
references.pmid: 2525423
references.citation: J Oral Pathol Med. 2004 Mar;33(3):185-90
references.pmid: 15128061
references.citation: Dev Biol. 1987 Mar;120(1):186-97
references.pmid: 3493183
references.citation: J Clin Pediatr Dent. 1998 Fall;23(1):55-8
references.pmid: 10023235