title: Cardiac memory: The slippery slope twixt normalcy and pathology.
abstract: "Cardiac memory" is an altered repolarization phenotype resulting from prior cardiac rate, rhythm, and/or activation changes. The various types of memory depend on biophysical properties of cardiac ion channels, trafficking of those channels, and/or epigenetic changes in the genes determining the channels. The processes that engage the memory function presage changes in function that ultimately can lead to pathological remodeling. Hence--rather than completely benign--memory may be a warning of disease to come. This article considers the forms, the mechanisms, and the clinical expression of cardiac memory.
authors.affiliation: Departments of Pharmacology and Pediatrics, Columbia University Medical Center, New York, NY. Electronic address: mrr1@columbia.edu.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rosen
authors.affiliation: Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: Lennart
authors.initials: L
authors.lastname: Bergfeldt
mesh_terms: D000200:Action Potentials / Q000502:physiology; D001145:Arrhythmias, Cardiac / Q000503:physiopathology* / Q000628:therapy; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002320:Cardiovascular Physiological Phenomena; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology; D014672:Vectorcardiography; D020257:Ventricular Remodeling / Q000502:physiology*