title: Down-regulated E-cadherin expression is associated with poor five-year overall survival in bone and soft tissue sarcoma: results of a meta-analysis.
abstract: OBJECTIVE
  To conduct a meta-analysis to evaluate the prognostic role of E-cadherin expression in bone and soft tissue sarcomas.
  
  
  METHODS
  The PubMed, EMBASE, and Web of Science databases were searched using terms related to E-cadherin, sarcoma, and prognosis for all articles published in English before March 2014. Pooled effect was calculated from the available data to evaluate the association between negative E-cadherin expression and 5-year overall survival and tumor clinicopathological features in sarcoma patients. Pooled odds ratios (OR) and risk ratios (RR) with 95% confidence intervals (CI) were calculated using a fixed-effects model.
  
  
  RESULTS
  Eight studies met the selection criteria and reported on 812 subjects. A total of 496 subjects showed positive E-cadherin expression (59.9%). Negative E-cadherin expression in bone and soft tissue sarcomas was correlated with lower 5-year overall survival (OR = 3.831; 95% CI: 2.246-6.534), and was associated with higher clinical stage (RR = 1.446; 95% CI: 1.030-2.028) and with male sex (RR = 0.678; 95% CI: 0.493-0.933).
  
  
  CONCLUSIONS
  In the E-cadherin negative group, 5-year overall survival was significantly worse than in the E-cadherin positive group. However, further studies are required to confirm these results.
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of ICU intensive care, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
authors.forename: Yong-Lai
authors.initials: YL
authors.lastname: He
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Li-Juan
authors.initials: LJ
authors.lastname: Pang
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zou
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Liu
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Hu
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Pathology, Shihezi University School of Medicine, Shihezi, Xinjiang, China; Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University and Chinese Ministry of Education, Shihezi, Xinjiang, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D001859:Bone Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012509:Sarcoma / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D015820:Cadherins; D025521:Tumor Suppressor Proteins
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