title: UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.
abstract: UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.
authors.affiliation: Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina.
authors.forename: Eduardo R
authors.initials: ER
authors.lastname: Lazarowski
authors.affiliation: Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina tkh@med.unc.edu.
authors.forename: T Kendall
authors.initials: TK
authors.lastname: Harden
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000378:metabolism; D058470:Receptors, Purinergic P2Y / Q000378:metabolism*; D015398:Signal Transduction; D014539:Uridine Diphosphate Sugars / Q000378:metabolism*
chemical_list: D058470:Receptors, Purinergic P2Y; D014539:Uridine Diphosphate Sugars
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