title: Potential pharmacological interventions against hematotoxicity: an overview.
abstract: Various treatment regimens, including chemotherapy, are known to induce heavy oxidative stress on the system, which in turn leads to adverse effects on healthy tissues. Blood being prone to oxidative stress is affected the most. At this juncture, it might not be prudent to anticipate having chemotherapeutic agents with no hematotoxicity; the best way forward is to look for potential anti-hematotoxic compounds, which could be supplemented to exposed patients, thus reducing the toxic burden on blood cells. We mined existing literature for reviewing possible interventions against hematotoxicity and figured that there is a great lacuna in this field in terms of not having such useful information at one place. This review presents the possible entities based on their antioxidant potentials, including their mechanistic pathways.
authors.affiliation: Academy for Scientific and Innovative Research, New Delhi 110 001, India.
authors.forename: Pooja
authors.initials: P
authors.lastname: Shukla
authors.forename: Rama
authors.initials: R
authors.lastname: Singh
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D006402:Hematologic Diseases / Q000188:drug therapy* / Q000209:etiology*; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D019172:Transplantation Conditioning / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D016298:Hematopoietic Cell Growth Factors
keywords: anti-hematotoxic; cancer; chemotherapeutic; hematotoxicity; oxidative stress