title: Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid.
abstract: BACKGROUND
  Spectral domain enhanced depth imaging optical coherence tomography (EDI-OCT) can provide anatomic localization of intraocular tumors.
  
  
  OBJECTIVE
  The aim was to identify topographical and intrinsic patterns of choroidal tumors on EDI-OCT.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Analysis of published reports and personal observations using office based EDI-OCT.
  
  
  RESULTS
  Using EDI-OCT, choroidal nevus displayed a smooth, dome-shaped topography with overlying retinal pigment epithelium alterations, drusen, and occasional subretinal cleft demonstrating photoreceptor loss. Small choroidal melanoma showed smooth, moderately dome-shaped topography, commonly with overlying shallow subretinal fluid that often depicted "shaggy" photoreceptors. Choroidal metastasis showed a minimally "lumpy, bumpy" surface topography and with overlying subretinal fluid and shaggy photoreceptors. Choroidal hemangioma showed a smooth, dome-shaped topography, with expansion of the affected small, medium, and large choroidal vessels. Choroidal lymphoma showed varying topography with increasing tumor thickness as "flat, rippled, or undulating (seasick)" surface. Choroidal osteoma displayed a smooth undulating surface with visible intralesional horizontal lines suggestive of bone lamellae and occasional horizontal and vertical tubules with intralesional "spongy" flecks. Choroidal melanocytosis appeared as uniformly thickened choroid with increased stromal density surrounding the normal choroidal vascular structures.
  
  
  CONCLUSIONS
  Enhanced depth imaging-OCT can depict characteristic patterns that are suggestive of various choroidal tumors.
authors.affiliation: Department of Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
authors.forename: Janet
authors.initials: J
authors.lastname: Manalac
authors.forename: Chandana
authors.initials: C
authors.lastname: Das
authors.forename: Jarin
authors.initials: J
authors.lastname: Saktanasate
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Shields
mesh_terms: D002829:Choroid / Q000473:pathology*; D002830:Choroid Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007089:Image Enhancement; D041623:Tomography, Optical Coherence / Q000379:methods*
references.citation: Arch Ophthalmol. 2007 Nov;125(11):1501-7
references.pmid: 17998511
references.citation: Br J Ophthalmol. 2004 Jan;88(1):120-4
references.pmid: 14693788
references.citation: Retina. 2014 Jul;34(7):1354-9
references.pmid: 24351445
references.citation: Ophthalmology. 2010 Aug;117(8):1630-7
references.pmid: 20417564
references.citation: Ophthalmology. 2011 Dec;118(12):2474-9
references.pmid: 22018683
references.citation: Ophthalmology. 2005 Oct;112(10):1784-9
references.pmid: 16154197
references.citation: Ophthalmology. 2012 May;119(5):1066-72
references.pmid: 22297027
references.citation: Science. 1991 Nov 22;254(5035):1178-81
references.pmid: 1957169
references.citation: Retina. 2005 Apr-May;25(3):243-52
references.pmid: 15805899
references.citation: Retina. 2014 Aug;34(8):1495-512
references.pmid: 25014847
references.citation: Retina. 2014 Jul;34(7):1347-53
references.pmid: 24569490
references.citation: Ophthalmology. 2008 Mar;115(3):546-552.e2
references.pmid: 18067966
references.citation: Arch Ophthalmol. 2009 Aug;127(8):989-98
references.pmid: 19667335
references.citation: Retina. 2013 Jul-Aug;33(7):1293-9
references.pmid: 23751944
references.citation: Retina. 2014 May;34(5):958-63
references.pmid: 24263470
references.citation: Am J Ophthalmol. 2008 Oct;146(4):496-500
references.pmid: 18639219
references.citation: Curr Opin Ophthalmol. 2005 Jun;16(3):141-54
references.pmid: 15870570
references.citation: Arch Ophthalmol. 2000 Mar;118(3):360-4
references.pmid: 10721958
references.citation: Arch Ophthalmol. 2009 Mar;127(3):314-9
references.pmid: 19273796
references.citation: Ophthalmology. 1997 Aug;104(8):1265-76
references.pmid: 9261313
references.citation: Eye (Lond). 2012 Dec;26(12):1598-9
references.pmid: 23037908
references.citation: Arch Ophthalmol. 1998 Oct;116(10):1337-41
references.pmid: 9790633
references.citation: J Fr Ophtalmol. 2013 Mar;36(3):e37-40
references.pmid: 23201343
references.citation: Am J Ophthalmol. 2004 Jan;137(1):90-5
references.pmid: 14700649
references.citation: Eur J Ophthalmol. 2011 May-Jun;21(3):271-5
references.pmid: 21038307
references.citation: Retina. 2015 Apr;35(4):750-7
references.pmid: 25296127
references.citation: Retina. 2011 Feb;31(2):336-43
references.pmid: 21102373
references.citation: Eye (Lond). 2013 Feb;27(2):208-16
references.pmid: 23196648
references.citation: Surv Ophthalmol. 1988 Jul-Aug;33(1):17-27
references.pmid: 3051466
references.citation: J Ophthalmol. 2012;2012:385058
references.pmid: 23008756
references.citation: Arch Ophthalmol. 2012 Jul;130(7):850-6
references.pmid: 22776921
references.citation: Ophthalmology. 2005 Sep;112(9):1612-9
references.pmid: 16039718
references.citation: Ophthalmology. 2014 Jan;121(1):342-351
references.pmid: 23978622
references.citation: Middle East Afr J Ophthalmol. 2015 Apr-Jun;22(2):192-7
references.pmid: 25949077
references.citation: Ophthalmology. 1998 Jan;105(1):195-8
references.pmid: 9442799
references.citation: Arch Ophthalmol. 2005 Dec;123(12):1658-66
references.pmid: 16344436
references.citation: Retina. 2014 Aug;34(8):1588-93
references.pmid: 24743640
references.citation: Ophthalmology. 2011 Dec;118(12):2468-73
references.pmid: 21820181
references.citation: Ophthalmology. 2001 Dec;108(12):2237-48
references.pmid: 11733265
references.citation: Br J Ophthalmol. 2012 Feb;96(2):224-8
references.pmid: 21527415
references.citation: Ophthalmology. 2007 Dec;114(12):e53-8
references.pmid: 17884171
references.citation: Ophthalmology. 2014 Jan;121(1):257-261
references.pmid: 24139152
references.citation: Arch Ophthalmol. 2009 Aug;127(8):981-7
references.pmid: 19667334