title: Electrospun polyacrylonitrile nanofibers loaded with silver nanoparticles by silver mirror reaction.
abstract: The silver mirror reaction (SMR) method was selected in this paper to modify electrospun polyacrylonitrile (PAN) nanofibers, and these nanofibers loaded with silver nanoparticles showed excellent antibacterial properties. PAN nanofibers were first pretreated in AgNO3 aqueous solution before the SMR process so that the silver nanoparticles were distributed evenly on the outer surface of the nanofibers. The final PAN nanofibers were characterized by scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), transmission electron microscopy (TEM), TEM-selected area electron diffraction (SAED), X-ray diffraction (XRD) and thermogravimetric analysis (TGA). SEM, TEM micrographs and SAED patterns confirmed homogeneous dispersion of the silver nanoparticles which were composed of monocrystals with diameters 20-30nm. EDS and XRD results showed that these monocrystals tended to form face-centered cubic single silver. TGA test indicated that the nanoparticles loaded on the nanofibers reached above 50wt.%. This material was also evaluated by the viable cell-counting method. The results indicated that PAN nanofibers loaded with silver nanoparticles exhibited excellent antimicrobial activities against gram-negative Escherichia coli (E. coli), gram-positive Staphylococcus aureus (S. aureus) and the fungus Monilia albicans. Thus, this material had many potential applications in biomedical fields.
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Yongzheng
authors.initials: Y
authors.lastname: Shi
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Zhongzhen
authors.initials: Z
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Organic-Inorganic Composites, Key Laboratory of Carbon Fiber and Functional Polymers, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: yangdz@mail.buct.edu.cn.
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003460:Crystallization / Q000379:methods; D004595:Electroplating / Q000379:methods; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012399:Rotation; D012834:Silver / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D053769:Nanocapsules; D012834:Silver
keywords: Antibacterial activity; Biomaterials; Electrospun; Nanoparticles; Polyacrylonitrile