title: Dermatology facing autoinflammatory syndrome.
abstract: Cutaneous symptoms are characteristic for the autoinflammatory disorders (AIDs), both in the classical autoinflammatory phenotype and in most disorders included in this syndrome, but they are not specific and inconstant. Several skin disorders (pyoderma gangrenosum and pustular acne) may be encountered either isolate or associated with autoinflammatory symptoms, forming well-defined clinical entities within the autoinflammatory syndrome. The high prevalence of cutaneous manifestations is an important characteristic of AIDs. The presence of cutaneous symptoms in AIDs opens the perspective of understanding the contribution of innate immunity mechanisms involved in skin pathology. It is possible that many diseases present the alteration, in various degrees, of the innate immune mechanisms. Recently, dermatology faced two challenges connected to AIDs. The first involves the diagnosis of skin symptoms in a clinical autoinflammatory setting and the investigative approach to identify a disorder classified as AID. The second is to identify the altered mechanisms of inborn immunity among the pathogenetic mechanisms of known dermatological diseases (e.g., neutrophilic dermatoses). On the other hand, cutaneous symptoms are in certain cases regarded as a criterion to asses the efficacy of specific or non-specific therapies with monoclonal antibodies in disorders included in AIDs. Dermatology mostly benefits from the identification and knowledge of AIDs due to the role of innate immunity in skin pathogeny and also due to the large extent of clinical forms resulting from the association of skin symptoms with other disorders included in this group.
authors.affiliation: Department of Dermatology, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, Bucharest, Romania; noime85@yahoo.com.
authors.forename: Mihail
authors.initials: M
authors.lastname: Alecu
authors.forename: Gabriela
authors.initials: G
authors.lastname: Coman
authors.forename: Alina
authors.initials: A
authors.lastname: Muşetescu
authors.forename: Marian Emanuel
authors.initials: ME
authors.lastname: Cojoacă
authors.forename: Oana Andreia
authors.initials: OA
authors.lastname: Coman
mesh_terms: D000152:Acne Vulgaris / Q000276:immunology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000737:chemistry; D003165:Complement System Proteins / Q000378:metabolism; D003880:Dermatology / Q000379:methods*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000188:drug therapy*; D053583:Interleukin-1beta / Q000378:metabolism; D008264:Macrophages; D009154:Mutation; D010641:Phenotype; D017511:Pyoderma Gangrenosum / Q000276:immunology; D011994:Recombinant Proteins / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000503:physiopathology; D012871:Skin Diseases / Q000276:immunology*; D012879:Skin Physiological Phenomena
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D053583:Interleukin-1beta; D011994:Recombinant Proteins; D003165:Complement System Proteins