title: Adherence to a pedometer-based physical activity intervention following kidney transplant and impact on metabolic parameters.
abstract: The majority of kidney transplant recipients die from cardiovascular events. Physical activity may be a modifiable risk factor for cardiovascular disease following transplant. The goal of our study was to examine adherence to a physical activity intervention following kidney transplant and its impact on metabolic parameters. All patients who received a kidney transplant at our center between 12/2010 and 12/2011 received usual care (n = 162), while patients transplanted between 12/2011 and 1/2013 received a 90-day pedometer-based physical activity intervention (n = 145). Metabolic parameters were assessed at four and 12 months post-transplant. Baseline demographics and clinical management were similar between cohorts. Adherence to the prescription was 36.5%. Patients in the physical activity cohort had lower systolic and diastolic blood pressure four months post-transplant compared to the usual care cohort (122 ± 18 vs. 126 ± 16 mmHg, p = 0.049 and 73 ± 10 vs. 77 ± 9, p = 0.004) and less impaired fasting glucose (20.7% vs. 30.9%, p = 0.04). Twelve-month outcomes were not different between cohorts. Over one-third of our cohort adhered to a pedometer-based physical activity intervention following kidney transplant, and the intervention was associated with improved metabolic parameters. Further study of post-transplant exercise interventions and methods to optimize long-term adherence are needed.
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.|William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Lorenz
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.|William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
authors.forename: Hatem
authors.initials: H
authors.lastname: Amer
authors.affiliation: William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.|Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Dean
authors.affiliation: William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.|Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Stegall
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.|William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN, USA.
authors.forename: Fernando G
authors.initials: FG
authors.lastname: Cosio
authors.affiliation: Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Cheville
mesh_terms: D056044:Actigraphy; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D005081:Exercise Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D011182:Postoperative Care; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: blood pressure; cardiovascular disease; exercise; kidney transplant; metabolic outcomes