title: [New antibiotics produced by Bacillus subtilis strains].
abstract: Two Bacillus subtilis strains isolated from the fruiting body of a basidiomycete fungus Pholiota squarrosa exhibited a broad range of antibacterial activity, including those against methicillin-resistant Staphylococcus aureus INA 00761 (MRSA) and Leuconostoc mes6nteroides VKPM B-4177 resistant to glycopep-> tide antibiotics, as well as antifungal activity. The strains were identified as belonging to the "B. subtilis" com- plex based on their morphological and physiological characteristics, as well as by sequencing of the 16S rRNA gene fragments. Both strains (INA 01085 and INA 01086) produced insignificant amounts of polyene antibiotics (hexaen and pentaen, respectively). Strain INA 01086 produced also a cyclic polypeptide antibiotic containing Asp, Gly, Leu, Pro, Tyr, Thr, Trp, and Phe, while the antibiotic of strain INA 01085 contained, apart from these, two unidentified nonproteinaceous amino acids. Both polypeptide antibiotics were new compounds efficient against gram-positive bacteria and able to override the natural bacterial antibiotic resistance.
authors.forename: I A
authors.initials: IA
authors.lastname: Malanicheva
authors.forename: D G
authors.initials: DG
authors.lastname: Kozlov
authors.forename: T A
authors.initials: TA
authors.lastname: Efimenko
authors.forename: V A
authors.initials: VA
authors.lastname: Zenkova
authors.forename: G S
authors.initials: GS
authors.lastname: Kastrukha
authors.forename: M I
authors.initials: MI
authors.lastname: Reznikova
authors.forename: A M
authors.initials: AM
authors.lastname: Korolev
authors.forename: L N
authors.initials: LN
authors.lastname: Borshchevskaia
authors.forename: O D
authors.initials: OD
authors.lastname: Tarasova
authors.forename: S P
authors.initials: SP
authors.lastname: Sineokiĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Efremenkova
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001412:Bacillus subtilis / Q000737:chemistry / Q000378:metabolism*; D007934:Leuconostoc / Q000254:growth & development*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000254:growth & development*; D055368:Pholiota / Q000254:growth & development*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents