title: The relationship of CSF and plasma cytokine levels in HIV infected patients with neurocognitive impairment.
abstract: Although HAD is now rare due to HAART, the milder forms of HAND persist in HIV-infected patients. HIV-induced systemic and localized inflammation is considered to be one of the mechanisms of HAND. The levels of cytokines in CSF were associated with neurocognitive impairment in HIV infection. However, the changes of cytokines involved in cognition impairment in plasma have not been shown, and their relationships between CSF and plasma require to be addressed. We compared cytokine levels in paired CSF and plasma samples from HIV-infected individuals with or without neurocognitive impairment. Cytokine concentrations were measured by Luminex xMAP. In comparing the expression levels of cytokines in plasma and CSF, IFN-α2, IL-8, IP-10, and MCP-1 were significantly higher in CSF. Eotaxin was significantly higher in plasma, whereas G-CSF showed no difference between plasma and CSF. G-CSF (P = 0.0079), IL-8 (P = 0.0223), IP-10 (P = 0.0109), and MCP-1 (P = 0.0497) in CSF showed significant difference between HIV-CI and HIV-NC group, which may indicate their relationship to HIV associated neurocognitive impairment. In addition, G-CSF (P = 0.0191) and IP-10 (P = 0.0377) in plasma were significantly higher in HIV-CI than HIV-NC. The consistent changes of G-CSF and IP-10 in paired plasma and CSF samples might enhance their potential for predicting HAND.
authors.affiliation: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: An
authors.initials: A
authors.lastname: Liu
authors.affiliation: Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Luxin
authors.initials: L
authors.lastname: Qiao
authors.affiliation: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Sheng
authors.affiliation: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.affiliation: Center for Infectious Disease, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Dexi
authors.initials: D
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D016207:Cytokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines
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