title: Versicorin, a new lovastatin analogue from the fungus Aspergillus versicolor SC0156.
abstract: A new lovastatin analogue versicorin (1), together with three related compounds, decumbenones A (2) and B (3) and versiol (4), were isolated from mycelial solid cultures of Aspergillus versicolor SC0156. Their structures were elucidated on the basis of MS data and NMR spectroscopic analysis. The new compound versicorin (1) possesses a hexahydro-2H-naphtho[1,8-bc]furan moiety, which is a rare type of the lovastatin-analogous compounds. A hypothetical biosynthetic pathway for compounds 1-4 was proposed.
authors.affiliation: a Key Laboratory of Plant Resources Conservation and Sustainable Utilization/Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences , Xingke Road 723, Guangzhou 510650 , People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fu
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Jinghua
authors.initials: J
authors.lastname: Xue
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.forename: Hanxiang
authors.initials: H
authors.lastname: Li
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D006090:Gram-Negative Bacteria; D006094:Gram-Positive Bacteria; D006801:Humans; D008148:Lovastatin / Q000031:analogs & derivatives*; D015394:Molecular Structure
chemical_list: C000601244:versicorin; D008148:Lovastatin
keywords: Aspergillus versicolor; lovastatin analogue; secondary metabolites; soil fungus