title: Botulinum-A Toxin's efficacy in the treatment of idiopathic overactive bladder.
abstract: The systematic literature review was carried out to point out the efficacy of botulinum type A toxin (BTX-A) intra-detrusor injections in adults with idiopathic overactive bladder (OAB) and urgency urinary incontinence (UUI). A PubMed search for clinical studies with BTX-A intra-detrusor injections in adults with OAB was performed.The studies showed improvements in quality of life by relieving symptoms (decreased urinary frequency, urgency episodes, incontinence and nocturia). Randomised controlled trials conducted in the preceding two years showed complete continence in patients treated with BTX-A in 22.9% to 55% cases. Following treatment, most studies showed an increase in post-void residual volume, a fact that may lead to urinary tract infections (UTIs) and urinary retention requiring catheterisation. BTX-A is an effective treatment for OAB and results in a significant improvement in the quality of life of patients.
authors.forename: Marius Alexandru
authors.initials: MA
authors.lastname: Moga
authors.forename: Simona
authors.initials: S
authors.lastname: Banciu
authors.forename: Oana
authors.initials: O
authors.lastname: Dimienescu
authors.forename: Nicusor-florin
authors.initials: NF
authors.lastname: Bigiu
authors.forename: Ioan
authors.initials: I
authors.lastname: Scarneciu
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D011788:Quality of Life; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A