title: Nonurothelial bladder cancer and rare variant histologies.
abstract: At present, radical cystectomy is a mainstay in the management of all bladder cancers, whether of conventional urothelial histology or variant. However, in the case of some variants, it is clearly not enough and multimodal therapy is an imperative. In other cases, systemic therapy might be ineffective or even detrimental if it leads to delay in surgery (ie, squamous cell carcinoma). Thus, identification of variant histology is a critical part of bladder cancer staging because such histology may require appropriately tailored therapy.
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373 Houston, TX 77030, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Willis
authors.affiliation: The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373 Houston, TX 77030, USA. Electronic address: akamat@mdanderson.org.
authors.forename: Ashish M
authors.initials: AM
authors.lastname: Kamat
mesh_terms: D019468:Disease Management; D006801:Humans; D060787:Neoplasm Grading; D011379:Prognosis; D035583:Rare Diseases; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy
keywords: Chemotherapy; Micropapillary bladder cancer; Radical cystectomy; Treatment guidelines; Urothelial carcinoma; Variant histology