title: Fixed drug eruption to sitagliptin.
abstract: Fixed drug eruption is a common adverse effect seen with various drugs notably antibiotics, antiepileptics and non-steroidal anti-inflammatory drugs. Herein we report a case of Sitagliptin induced fixed drug eruption in a 46 year old female who developed circumscribed, erythematous macules all over the body within one week of initiation of Sitagliptin. The lesions resolved with residual hyperpigmentation on cessation of the drug. The diagnosis was confirmed by an oral provocation test which led to a reactivation of the lesions. To the best of our knowledge, this is the first case of fixed drug eruption to Sitagliptin reported in the literature.
authors.affiliation: Sudhaa Skin Centre, Jammu, 180019 India.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Acharya Shri Chander College of Medical Sciences, Jammu, 180019 India.
authors.forename: Anish
authors.initials: A
authors.lastname: Gupta
keywords: Fixed drug eruption; Oral provocation test; Sitagliptin
references.citation: J Dermatol. 2012 Aug;39(8):726-8
references.pmid: 21981936
references.citation: Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):316-21
references.pmid: 19474709
references.citation: Dermatol Online J. 2012 Feb 15;18(2):9
references.pmid: 22398230
references.citation: Diabetes Ther. 2012 Dec;3(1):14
references.pmid: 23129260
references.citation: Clin Pharmacol Ther. 1981 Aug;30(2):239-45
references.pmid: 7249508
references.citation: Allergy Asthma Immunol Res. 2014 Sep;6(5):415-20
references.pmid: 25228998
references.citation: J Eur Acad Dermatol Venereol. 2012 Feb;26(2):249-53
references.pmid: 21466592
references.citation: Arch Intern Med. 2010 Jul 12;170(13):1169-71
references.pmid: 20625027