title: The development or exacerbation of eating disorder symptoms after topiramate initiation.
abstract: The Food and Drug Administration recently approved topiramate for migraine prevention in adolescents. Given the well-established appetite-suppressant side effects of topiramate, as well as data suggesting a potential comorbidity between migraine and eating disorders, susceptible young migraine patients may be at a greater risk for the development or worsening of eating disorder symptoms with topiramate therapy. This case series comprises 7 adolescent patients in whom serious eating disorders developed or were exacerbated after the initiation of topiramate therapy. Clinical characteristics of these patients are highlighted. In addition, this case series provides guidelines for providers to use in assessing eating disorders before prescribing topiramate for migraine prevention in adolescents.
authors.affiliation: Departments of Psychiatry and Psychology and Departments of Psychiatry and Behavioral Sciences and j.lebow@med.miami.edu.
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Lebow
authors.affiliation: Radiology, Miller School of Medicine, University of Miami, Miami, Florida.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Chuy
authors.affiliation: Departments of Psychiatry and Psychology and.
authors.forename: Kyle
authors.initials: K
authors.lastname: Cedermark
authors.affiliation: Cardiovascular Disease, Mayo Clinic College of Medicine, Rochester, Minnesota; and.
authors.forename: Katlyn
authors.initials: K
authors.lastname: Cook
authors.affiliation: Departments of Psychiatry and Psychology and.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Sim
mesh_terms: D000293:Adolescent; D018450:Disease Progression; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D012189:Retrospective Studies; D000077236:Topiramate
chemical_list: D000077236:Topiramate; D005632:Fructose
keywords: eating disorders; migraine; topiramate