title: Inhibition of ENaC by endothelin-1.
abstract: The amiloride-sensitive epithelial Na(+) channel (ENaC) is a key player in the regulation of Na(+) homeostasis. Its functional activity is under continuous control by a variety of signaling molecules, including bioactive peptides of endothelin family. Since ENaC dysfunction is causative for disturbances in total body Na(+) levels associated with the abnormal regulation of blood volume, blood pressure, and lung fluid balance, uncovering the molecular mechanisms of inhibitory modulation or inappropriate activation of ENaC is crucial for the successful treatment of a variety of human diseases including hypertension. The precise regulation of ENaC is particularly important for normal Na(+) and fluid homeostasis in organs where endothelins are known to act: the kidneys, lung, and colon. Inhibition of ENaC by endothelin-1 (ET-1) has been established in renal cells, and several molecular mechanisms of inhibition of ENaC by ET-1 are proposed and will be reviewed in this chapter.
authors.affiliation: Division of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: sorokin@mcw.edu.
authors.forename: Andrey
authors.initials: A
authors.lastname: Sorokin
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address: staruschenko@mcw.edu.
authors.forename: Alexander
authors.initials: A
authors.lastname: Staruschenko
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D019332:Endothelin-1 / Q000378:metabolism*; D053503:Epithelial Sodium Channels / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D012964:Sodium / Q000378:metabolism*
chemical_list: D019332:Endothelin-1; D053503:Epithelial Sodium Channels; D012964:Sodium
keywords: Blood pressure; Collecting duct; ET-1; ETRA; ETRB; Signal transduction; Sodium reabsorption; βPix
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