title: Three minimal sequences found in Ebola virus genomes and absent from human DNA.
abstract: BACKGROUND
  Ebola virus causes high mortality hemorrhagic fevers, with more than 25 000 cases and 10 000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed.
  
  
  RESULTS
  Analysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that appear nowhere in the human genome. We identify the shortest such sequences with lengths between 12 and 14. Only three absent sequences of length 12 exist and they consistently appear at the same location on two of the Ebola virus proteins, in all Ebola virus genomes, but nowhere in the human genome. The alignment-free method used is able to identify pathogen-specific signatures for quick and precise action against infectious agents, of which the current Ebola virus outbreak provides a compelling example.
authors.affiliation: IEETA and.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Silva
authors.affiliation: IEETA and DETI, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
authors.forename: Diogo
authors.initials: D
authors.lastname: Pratas
authors.affiliation: IEETA and.
authors.forename: Luísa
authors.initials: L
authors.lastname: Castro
authors.affiliation: IEETA and DETI, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
authors.forename: Armando J
authors.initials: AJ
authors.lastname: Pinho
authors.affiliation: IEETA and DETI, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.
authors.forename: Paulo J S G
authors.initials: PJ
authors.lastname: Ferreira
mesh_terms: D004279:DNA, Viral / Q000737:chemistry*; D004196:Disease Outbreaks; D029043:Ebolavirus / Q000235:genetics*; D015894:Genome, Human; D016679:Genome, Viral; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000821:virology; D006801:Humans; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins
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