title: Myosin-X and disease.
abstract: Myosin-X (Myo10) is a motor protein best known for its role in filopodia formation. New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. This review focuses on these developments with emphasis on the emerging roles of Myo10 in formation of cancer cell protrusions and metastasis. A number of aggressive cancers show high levels of Myo10 expression and knockdown of Myo10 has been shown to dramatically limit cancer cell motility in 2D and 3D systems. Myo10 knockdown also limits spread of intracellular pathogens marburgvirus and Shigella flexneri. Consideration is given to how these properties might arise and potential paths of future research.
authors.affiliation: Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
authors.forename: David S
authors.initials: DS
authors.lastname: Courson
authors.affiliation: Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address: richard_cheney@med.unc.edu.
authors.forename: Richard E
authors.initials: RE
authors.lastname: Cheney
mesh_terms: D006801:Humans; D009218:Myosins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: C498718:MYO10 protein, human; D009218:Myosins
keywords: Cancer; Filopodia; Infectious disease; Metastasis; Myo10; Myosin-X
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