title: Studies on the development of ¹⁶⁹Yb-brachytherapy seeds: New generation brachytherapy sources for the management of cancer.
abstract: This paper describes development of (169)Yb-seeds by encapsulating 0.6-0.65 mm (ϕ) sized (169)Yb2O3 microspheres in titanium capsules. Microspheres synthesized by a sol-gel route were characterized by XRD, SEM/EDS and ICP-AES. Optimization of neutron irradiation was accomplished and (169)Yb-seeds up to 74 MBq of (169)Yb could be produced from natural Yb2O3 microspheres, which have the potential for use in prostate brachytherapy. A protocol to prepare (169)Yb-brachytherapy sources (2.96-3.7 TBq of (169)Yb) with the use of enriched targets was also formulated.
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. Electronic address: sksaxena@barc.gov.in.
authors.forename: Sanjay Kumar
authors.initials: SK
authors.lastname: Saxena
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Yogendra
authors.initials: Y
authors.lastname: Kumar
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: K C
authors.initials: KC
authors.lastname: Jagadeesan
authors.affiliation: Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Nuwad
authors.affiliation: Fuel Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Y R
authors.initials: YR
authors.lastname: Bamankar
authors.affiliation: Isotope Production & Applications Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Dash
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D006801:Humans; D008297:Male; D008863:Microspheres; D009502:Neutrons; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011868:Radioisotopes / Q000008:administration & dosage* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000627:therapeutic use; D013052:Spectrometry, X-Ray Emission; D013499:Surface Properties; D014025:Titanium; D015018:Ytterbium / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; D014025:Titanium; D015018:Ytterbium
keywords: (169)Yb; Brachytherapy; EDS; Leachability; Microspheres; SEM; Sol–gel