title: Implementation of newborn screening for hemoglobin h disease in mainland china.
abstract: Hemoglobin H disease is the most severe non-fatal form of α-thalassemia syndrome characterized by pronounced microcytic hypochromic hemolytic anemia. It is predominantly seen in Southeast Asia, the Middle East and the Mediterranean. Studies suggest that hemoglobin H disease is not as benign a disorder as previously thought. Newborn screening for hemoglobin H disease is especially appealing because the screening test is based on the detection of hemoglobin Bart's (γ4) that is only possible within the newborn period. In this study, we reported on a 4-year period of newborn screening program at a mainland Chinese hospital, which detected 35 babies with hemoglobin H disease in a total of 26 152 newborns. The overall prevalence for hemoglobin H disease among all newborns in southern China is ~1 in 1,000. These children need appropriate follow-up and potential comprehensive care during their growth and development.
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Xie
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhou
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Ru
authors.initials: R
authors.lastname: Li
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Can
authors.initials: C
authors.lastname: Liao
authors.affiliation: Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical University, Jinsui Road 9, Zhujiang New Town, Guangzhou, 510623 Guangdong People's Republic of China.
authors.forename: Dong-Zhi
authors.initials: DZ
authors.lastname: Li
keywords: Hemoglobin H disease; Newborn screening; α-Thalassemia
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