title: Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia.
abstract: Tao-Hong-Si-Wu decoction (TSD) as a traditional chinese medicine (TCM) has been developed to treat thrombotic diseases for hundreds of years, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. In this study, the protective effect of TSD on memory impairment and brain damage in rat model of VD induced by middle cerebral artery occlusion (MCAO) was investigated. The study showed that rats in MCAO treatment with TSD for 14 days significantly improved behavioral function, increased densities of neuron, and induced angiogenesis in the brain compared with model rats. TSD also adjusted the neurotransmitter levels, reduced the content of endothelin-1 (ET-1), and induced the activities of vascular endothelial growth factor (VEGF) in hippocampus. Moreover, the immunohistochemical staining and western blotting results also revealed that TSD decreased apoptosis via upregulated B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax) ratio. These results demonstrated TSD possesses neuroprotective and antidementia properties by preventing the loss of neural cells, adjusting brain neurotransmitter, promoting cerebral blood circulation, and decreasing apoptosis. These results suggested that TSD might be developed as an effective drug for the prevention of VD.
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Han
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Zhaojie
authors.initials: Z
authors.lastname: Ji
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Dengke
authors.initials: D
authors.lastname: Yin
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Li
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Pharmacy, Maanshan Central Hospital, No. 27, Hudong Bei Road, Maanshan 243000, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhu
authors.affiliation: School of Pharmacy, Anhui University of Traditional Chinese Medicine, Xiangshan Road, Hefei 230012, China.
authors.forename: Daiyin
authors.initials: D
authors.lastname: Peng
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