title: Approach to chemotherapy-associated thrombosis.
abstract: Treatment of cancer patients with antineoplastic agents is associated with a heightened risk of thrombotic events, both arterial and venous. In this article, we review the specific agents that are implicated and the pathophysiological processes that are known to be associated with this prothrombotic state. We conclude with current recommendations for prophylactic antithrombotic therapy in these clinical situations.
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA peter.oppelt@uhhospitals.org.
authors.forename: Peter
authors.initials: P
authors.lastname: Oppelt
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Betbadal
authors.affiliation: Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Lalitha
authors.initials: L
authors.lastname: Nayak
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000150:complications; D011655:Pulmonary Embolism / Q000188:drug therapy*; D013923:Thromboembolism / Q000188:drug therapy*; D013927:Thrombosis / Q000139:chemically induced*
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents
keywords: angiogenesis inhibitors; anticoagulants; endothelial cells; pulmonary embolism; review; thromboembolism; thrombosis; venous thrombosis
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