title: Histopathology of lung disease in the connective tissue diseases.
abstract: The pathologic correlates of interstitial lung disease (ILD) secondary to connective tissue disease (CTD) comprise a diverse group of histologic patterns. Lung biopsies in patients with CTD-associated ILD tend to demonstrate simultaneous involvement of multiple anatomic compartments of the lung. Certain histologic patterns tend to predominate in each defined CTD, and it is possible in many cases to confirm connective tissue-associated lung disease and guide patient management using surgical lung biopsy. This article will cover the pulmonary pathologies seen in rheumatoid arthritis, systemic sclerosis, myositis, systemic lupus erythematosus, Sjögren syndrome, and mixed CTD.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Vivero
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address: rpadera@partners.org.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Padera
mesh_terms: D001706:Biopsy; D003240:Connective Tissue Diseases / Q000150:complications*; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*
keywords: Connective tissue disease; Histopathology; Interstitial lung disease; Myositis; Pathology; Rheumatoid arthritis; Scleroderma