title: Anilide formation from thioacids and perfluoroaryl azides.
abstract: A metal-free method for fast and clean anilide formation from perfluoroaryl azide and thioacid is presented. The reaction proved highly efficient, displaying fast kinetics, high yield, and good chemoselectivity. The transformation was compatible with various solvents and tolerant to a wide variety of functional groups, and it showed high performance in polar protic/aprotic media, including aqueous buffer systems.
authors.affiliation: †Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 36, S-10044 Stockholm, Sweden.
authors.forename: Sheng
authors.initials: S
authors.lastname: Xie
authors.affiliation: †Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 36, S-10044 Stockholm, Sweden.
authors.forename: Ryo
authors.initials: R
authors.lastname: Fukumoto
authors.affiliation: †Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 36, S-10044 Stockholm, Sweden.
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
authors.affiliation: †Department of Chemistry, KTH-Royal Institute of Technology, Teknikringen 36, S-10044 Stockholm, Sweden.|‡Department of Chemistry, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts 01854, United States.
authors.forename: Mingdi
authors.initials: M
authors.lastname: Yan
mesh_terms: D000813:Anilides / Q000138:chemical synthesis* / Q000737:chemistry; D001386:Azides / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000813:Anilides; D001386:Azides; D013438:Sulfhydryl Compounds; C005732:thioacetic acid