title: Biotoxicity of commonly used root canal sealers: A meta-analysis.
abstract: BACKGROUND
  The main objective of a root canal sealer is to provide a fluid tight seal. The purpose of this systematic meta-analysis was to determine the relative toxicity of commonly used root canal sealers like zinc oxide eugenol, calcium hydroxide, and resin-based sealers.
  
  
  METHODS
  An online search was conducted in peer-reviewed journals listed in PubMed, Cochrane, EBSCO, and IndMed databases between 2000 and 2012). Statistical analysis was carried out by using analysis of variance (ANOVA) followed by post-hoc comparison by Bonferroni method. The comparison between toxicity at 24 h and between 3 and 7 days was done by using paired t-test for each sealer.
  
  
  RESULTS
  At 24 h, the relative biotoxicity of the three sealers reported was insignificant (P- value 0.29), but the difference in toxicity was found significant (P < 0.001) after 3 days.
  
  
  CONCLUSIONS
  Calcium hydroxide sealer and zinc oxide eugenol were found to be significantly biotoxic as compared to resin-based sealers after 3 days.
authors.affiliation: Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Amandeep
authors.initials: A
authors.lastname: Kaur
authors.affiliation: Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Naseem
authors.initials: N
authors.lastname: Shah
authors.affiliation: Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Logani
authors.affiliation: Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Navin
authors.initials: N
authors.lastname: Mishra
keywords: Biocompatibility; cytotoxicity; meta-analysis; root canal sealers
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