title: Relationship Between Vertebral Fracture Burden, Height Loss, and Pulmonary Function in Postmenopausal Women With Osteoporosis.
abstract: The purpose of this analysis was to assess the association of osteoporosis-related vertebral fracture burden and pulmonary function. This study also examined the relationship between vertebral fracture burden and height loss, estimated by arm span - height. This was a single-site and single-visit study. Patients had a history of at least 1 moderate or severe vertebral fracture. Vertebral fracture burden was quantified using the spinal deformity index (SDI). Pulmonary function during inspiration was determined by spirometry. Forty-one women aged 70-91 completed the study. Vertebral fracture burden negatively correlated with forced inspiratory vital capacity and inspiratory time. For each unit increase in SDI, forced inspiratory vital capacity decreased by 1.62%, and inspiratory time decreased by 2.39%. There was no correlation between SDI and measures of inspiratory flow. For each unit increase in SDI, height decreased by about 0.5 cm. Vertebral fractures were associated with decreased lung volume and height loss.
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. Electronic address: krege_john_henry@lilly.com.
authors.forename: John H
authors.initials: JH
authors.lastname: Krege
authors.affiliation: University of British Columbia, Vancouver, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Kendler
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
authors.forename: Kelly
authors.initials: K
authors.lastname: Krohn
authors.affiliation: University of California San Francisco, San Francisco, CA, USA.
authors.forename: Harry
authors.initials: H
authors.lastname: Genant
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
authors.forename: Jahangir
authors.initials: J
authors.lastname: Alam
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Berclaz
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Coffey
authors.affiliation: Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA.
authors.forename: Corina
authors.initials: C
authors.lastname: Loghin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001827:Body Height; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D015663:Osteoporosis, Postmenopausal / Q000150:complications* / Q000503:physiopathology*; D013124:Spinal Injuries / Q000209:etiology* / Q000503:physiopathology; D013147:Spirometry
keywords: Height loss; lung volume; osteoporosis; pulmonary function; vertebral fractures