title: Six challenges in the eradication of infectious diseases.
abstract: Eradication and elimination are increasingly a part of the global health agenda. Once control measures have driven infection to low levels, the ecology of disease may change posing challenges for eradication efforts. These challenges vary from identifying pockets of susceptibles, improving monitoring during and after the endgame, to quantifying the economics of disease eradication versus sustained control, all of which are shaped and influenced by processes of loss of immunity, susceptible build-up, emergence of resistance, population heterogeneities and non-compliance with control measures. Here we discuss how modelling can be used to address these challenges.
authors.affiliation: Department of Applied Mathematics and Theoretical Physics, Cambridge University, Cambridge, UK. Electronic address: pklepac@alum.mit.edu.
authors.forename: Petra
authors.initials: P
authors.lastname: Klepac
authors.affiliation: Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Funk
authors.affiliation: Mathematics Institute and the School of Life Sciences, University of Warwick, UK; Liverpool School of Tropical Medicine, UK.
authors.forename: T Deirdre
authors.initials: TD
authors.lastname: Hollingsworth
authors.affiliation: Department of Ecology and Evolutionary Biology and the Woodrow Wilson School, Princeton University, Princeton, NJ, USA.
authors.forename: C Jessica E
authors.initials: CJ
authors.lastname: Metcalf
authors.affiliation: Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, UK.
authors.forename: Katie
authors.initials: K
authors.lastname: Hampson
mesh_terms: D003140:Communicable Disease Control / Q000191:economics / Q000379:methods; D003141:Communicable Diseases / Q000191:economics / Q000453:epidemiology / Q000276:immunology; D003362:Cost-Benefit Analysis; D060740:Disease Eradication / Q000191:economics / Q000379:methods*; D004198:Disease Susceptibility / Q000453:epidemiology; D006801:Humans; D015233:Models, Statistical; D011159:Population Surveillance
keywords: Dynamics; Elimination; Heterogeneity; Modelling; Surveillance
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