title: The multifaceted mitochondrion: An attractive candidate for therapeutic strategies.
abstract: Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments.
authors.affiliation: IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address: f.strappazzon@hsantalucia.it.
authors.forename: Flavie
authors.initials: F
authors.lastname: Strappazzon
authors.affiliation: IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
authors.forename: Francesco
authors.initials: F
authors.lastname: Cecconi
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D028361:Mitochondrial Diseases / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
keywords: Mitochondrial biogenesis; Mitochondrial plasticity; Mitochondrial quality control