title: Highly efficient ablation of metastatic breast cancer using ammonium-tungsten-bronze nanocube as a novel 1064 nm-laser-driven photothermal agent.
abstract: Photothermal ablation (PTA) therapy has been viewed as an invasive option for cancer therapy with minimal deconstruction of healthy tissues. In this study, a potent candidate of (NH4)xWO3 nanocube was developed for PTA treatment of metastatic breast cancer in the second near-infrared (NIR) window. It was found that the as-synthesized (NH4)xWO3 nanocube had significant photoabsorption across the whole NIR window of 780-2500 nm and exhibited considerable photo-heat conversion efficiency. Moreover, the as-prepared (NH4)xWO3 nanocube displayed good biocompatibility and high cellular uptake efficiency through endocytosis pathway without nuclei entry. The PTA study employing 1064 nm laser in the second NIR window revealed that (NH4)xWO3 nanocubes induced significant cell necrosis and apoptosis by producing obviously hyperthermia effect inside cancer cells. Using an orthotopicly implanted breast tumor model, it demonstrated that the (NH4)xWO3 nanocube was a promising photothermal agent for effective ablation of solid tumors and suppressing their distant metastasis.
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Chongshen
authors.initials: C
authors.lastname: Guo
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: hjyu@simm.ac.cn.
authors.forename: Haijun
authors.initials: H
authors.lastname: Yu
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Feng
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Gao
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Yan
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: ypli@simm.ac.cn.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Lab of Microsystem and Microstructure (Ministry of Education), Harbin Institute of Technology, Harbin 150080, China. Electronic address: shaoqinliu@hit.edu.cn.
authors.forename: Shaoqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D064751:Ammonium Compounds / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry; D004705:Endocytosis; D005260:Female; D007834:Lasers; D008027:Light; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000379:methods*; D019265:Spectroscopy, Near-Infrared; D014414:Tungsten / Q000737:chemistry
chemical_list: D064751:Ammonium Compounds; D001672:Biocompatible Materials; D003300:Copper; D014414:Tungsten
keywords: Cancer; Metastasis; Photothermal ablation therapy; Tungsten bronze