title: Contributions of Basal Glucose and Postprandial Glucose Concentrations to Hemoglobin A1c in the Newly Diagnosed Patients with Type 2 Diabetes--the Preliminary Study.
abstract: OBJECTIVE
  The aim of this preliminary study is to investigate contributions of basal glucose (BG) and postprandial glucose (PPG) increments to overall hyperglycemia in newly diagnosed patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  We evaluated the relative contributions of BG and PPG to overall hyperglycemia in 59 newly diagnosed T2DM patients according to BG baseline value of 6.1 mmol/L and 24-h glucose profiles of normal glucose tolerance (NGT) subjects obtained by continuous glucose monitoring as baseline, respectively.
  
  
  RESULTS
  When the baseline was 24-h glucose profiles of the NGT subjects, the relative contributions of PPG in the T2DM patients with hemoglobin A1c (HbA1c) levels of ≤ 7.0%, 7.0-9.0%, and >9.0% were 57.58%, 44.69%, and 21.56%, respectively. When the baseline value was equal to 6.1 mmol/L, the relative contributions of PPG in the T2DM patients with HbA1c levels of ≤ 7.0%, 7.0-9.0%, and >9.0% were 77.23%, 53.43%, and 22.78%, respectively. Compared with the 24-h glucose profiles of the NGT subjects as the baseline, the relative contribution of PPG was overestimated by about 10-20% in the T2DM patients with HbA1c levels of ≤ 9.0% when 6.1 mmol/L was chosen as the baseline.
  
  
  CONCLUSIONS
  In the newly diagnosed T2DM patients with mild hyperglycemia, PPG is a predominant contributor, whereas the relative contributions of BG gradually increase from mild to severe hyperglycemia and obviously exceed PPG in the T2DM patients with HbA1c levels of >9.0%. This finding implies that the initial pharmacotherapy may target PPG in those patients with mild hyperglycemia and target BG in those patients with severe hyperglycemia.
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Xin
authors.initials: X
authors.lastname: Kang
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Lifang
authors.initials: L
authors.lastname: Lv
authors.affiliation: 2 Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Guanjian
authors.initials: G
authors.lastname: Liu
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Yanzhi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Liping
authors.initials: L
authors.lastname: He
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Lihong
authors.initials: L
authors.lastname: Chen
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Xiujun
authors.initials: X
authors.lastname: Li
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Haoming
authors.initials: H
authors.lastname: Tian
authors.affiliation: 3 Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University , Shanghai, People's Republic of China .
authors.forename: Weiping
authors.initials: W
authors.lastname: Jia
authors.affiliation: 1 Department of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, People's Republic of China .
authors.forename: Xingwu
authors.initials: X
authors.lastname: Ran
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D015190:Blood Glucose Self-Monitoring; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
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