title: How and why neural and motor variation are related.
abstract: Movements are variable. Recent findings in smooth pursuit eye movements provide an explanation for motor variation in terms of the organization of the brain's sensory-motor pathways. Variation in sensory estimation is propagated through sensory-motor circuits and ultimately causes motor variation. The sensory origin of motor variation creates trial-by-trial correlations among the responses of neurons at each level of the sensory motor circuit, and between neural and behavioral responses. We suggest that motor variation is a compromise between multiple competing constraints. The brain strives for motor behavior that is 'good enough' in the face of constraints that tend to promote variation.
authors.affiliation: Department of Neurobiology, Howard Hughes Medical Institute, Duke University School of Medicine, Durham, NC, United States. Electronic address: lisberger@neuro.duke.edu.
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Lisberger
authors.affiliation: Department of Psychology, University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Javier F
authors.initials: JF
authors.lastname: Medina
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D006801:Humans; D008959:Models, Neurological; D009039:Motion Perception / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011698:Pursuit, Smooth / Q000502:physiology
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