title: A Meta-analysis of Central Corneal Thickness Changes With Overnight Orthokeratology.
abstract: OBJECTIVE
  To assess the change of central corneal thickness (CCT) in the treatment of orthokeratology in patients with myopia.
  
  
  METHODS
  A systematic search of all relevant studies published through April 2014 was conducted, and 95% confidence intervals (CI) of CCT change were calculated. Random or fixed-effects models were used according to heterogeneity. Publication bias of the articles was evaluated using funnel plots and Begg test.
  
  
  RESULTS
  A total of 10 studies with 239 patients (339 eyes) from clinical studies were included. Central corneal thickness reduced significantly from 1 day to 1 week by 5.73 μm (95% CI, 1.75-9.70 μm; P=0.005), and a significant mean reduction of 5.89 μm also occurred from 1 day to 1 month (95% CI, 3.50-8.29 μm; P<0.001). No significant reduction was found between 1 week and 1 month (P=0.32).
  
  
  CONCLUSIONS
  Our meta-analysis demonstrated that most reduction of CCT occurred during the first week and remained thinner for 1 month. Further randomized controlled trials with larger sample sizes, standardized outcome measurements, and different follow-up periods are warranted to find the precise change.
authors.affiliation: Tianjin Key Laboratory of Ophthalmology and Vision Science (F.L., Z.-X.J., P.H., X.L.), Tianjin Eye Hospital, Tianjin Eye Institute, Tianjin, China; and Medical School of Nankai University (F.L.), Tianjin, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Zhi-Xin
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Peng
authors.initials: P
authors.lastname: Hao
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
mesh_terms: D003261:Contact Lenses; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D006801:Humans; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D054158:Orthokeratologic Procedures; D012029:Refraction, Ocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology