title: Paraneoplastic retinopathy associated with systemic follicular cell lymphoma.
abstract: The authors describe two rare cases of autoimmune retinopathy associated with follicular cell lymphoma, including a 54-year-old man who experienced nyctalopia for 1 year (patient 1) and a 59-year-old man who had bilateral loss of central vision for 6 months (patient 2). Visual field testing of patient 1 revealed nonspecific defects, and multifocal electroretinogram (ERG) testing showed mildly subnormal amplitudes more pronounced in the left than the right eye. Serologic testing detected antibodies against a 47-kD protein, presumed to be alpha-enolase. Goldmann perimetry of patient 2 showed dense central scotomas, and a full-field ERG revealed reduced amplitudes of bright scotopic responses. Serological testing yielded anti-bipolar cell antibodies. A variable presentation of autoimmune retinopathy can occur in the setting of follicular cell lymphoma. Disparate serum autoantibodies may have mediated the pathogenesis of retinal degeneration in these two patients and could explain the difference in course and severity of retinopathy.
authors.forename: Kavita V
authors.initials: KV
authors.lastname: Bhavsar
authors.forename: Thomas
authors.initials: T
authors.lastname: Hedges
authors.forename: Charles E
authors.initials: CE
authors.lastname: Thirkill
authors.forename: Elias
authors.initials: E
authors.lastname: Reichel
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood*; D004596:Electroretinography; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009755:Night Blindness / Q000175:diagnosis; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis* / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D051245:Retinal Bipolar Cells / Q000276:immunology; D012607:Scotoma / Q000175:diagnosis; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D010751:Phosphopyruvate Hydratase