title: Minimally invasive treatment of a painful osteolytic lumbar lesion secondary to epithelioid hemangioendothelioma.
abstract: Study Design Case report. Objective Multifocal epithelioid hemangioendothelioma (EHE) of the spine is a rare disorder. We describe a novel, multimodal treatment of a painful osteolytic lumbar lesion secondary to EHE. The minimally invasive treatment results in an excellent patient outcome with decreased morbidity compared to traditional techniques. Methods A previously healthy young adult presented with a painful osteolytic lesion at the L2 vertebrae. Imaging revealed multifocal spinal lesions consistent with a history of EHE. Core needle biopsy confirmed the diagnosis. Preoperative cryoablation of L2 was followed by a staged surgery, which included a partial L2 corpectomy, tumor resection, bone grafting, and vertebral reconstruction using a minimally invasive technique. This treatment was followed by prolonged therapy with interferon and bisphosphonate. Results At 3.5 years' follow-up, the patient has maintained his vertebral body height, has not required a fusion, and has had no recurrence of disease. Conclusion Multimodal treatment consisting of tumor cryoablation, partial corpectomy, allograft reconstruction of the vertebrae, and adjuvant interferon and bisphosphonate can result in good outcomes for well-contained EHE tumors of the spine.
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Arjun S
authors.initials: AS
authors.lastname: Sebastian
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Adair
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Morris
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Mustafa H
authors.initials: MH
authors.lastname: Khan
authors.affiliation: Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Carola A S
authors.initials: CA
authors.lastname: Arndt
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minnesota, United States.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Nassr
keywords: MIS; cryoablation; intravertebral polyethylene mesh bag; multifocal spinal epithelioid hemangioendothelioma
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