title: In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer.
abstract: Current bio-medical imaging researches aim to detect brain micrometastasis in early stage for its increasing incidence and high mortality rates. Synchrotron phase-contrast imaging techniques, such as in-line phase-contrast (IPC) and grating-based phase-contrast (GPC) imaging, could provide a high spatial and density imaging study of biological specimens' 3D structures. In this study, we demonstrated the detection efficiencies of these two imaging tools on breast cancer micrometastasis in an ex vivo mouse brain. We found that both IPC and GPC can differentiate abnormal brain structures induced by micrometastasis from the surrounding normal tissues. We also found that GPC was more sensitive in detecting the small metastasis as compared to IPC.
authors.affiliation: Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Huang
authors.affiliation: Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Binquan
authors.initials: B
authors.lastname: Kou
authors.affiliation: Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Yayun
authors.initials: Y
authors.lastname: Chi
authors.affiliation: 1] School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China [2] Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xi
authors.affiliation: Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: 1] Department of Pathology, Fudan University, Shanghai Cancer Center, Shanghai, People's Republic of China [2] Department of Pathology, First Affiliated Hospital Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
authors.forename: Wenli
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Guo
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Tiqiao
authors.initials: T
authors.lastname: Xiao
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jianqi
authors.initials: J
authors.lastname: Sun
authors.affiliation: 1] School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China [2] Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D051379:Mice; D061206:Neoplasm Micrometastasis / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D017356:Synchrotrons
chemical_list: D003287:Contrast Media
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