title: Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest.
abstract: The mechanism by which the healthy heart and brain die rapidly in the absence of oxygen is not well understood. We performed continuous electrocardiography and electroencephalography in rats undergoing experimental asphyxia and analyzed cortical release of core neurotransmitters, changes in brain and heart electrical activity, and brain-heart connectivity. Asphyxia stimulates a robust and sustained increase of functional and effective cortical connectivity, an immediate increase in cortical release of a large set of neurotransmitters, and a delayed activation of corticocardiac functional and effective connectivity that persists until the onset of ventricular fibrillation. Blocking the brain's autonomic outflow significantly delayed terminal ventricular fibrillation and lengthened the duration of detectable cortical activities despite the continued absence of oxygen. These results demonstrate that asphyxia activates a brainstorm, which accelerates premature death of the heart and the brain.
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Duan
authors.initials: D
authors.lastname: Li
authors.affiliation: Chemistry, Pharmacology.
authors.forename: Omar S
authors.initials: OS
authors.lastname: Mabrouk
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Tiecheng
authors.initials: T
authors.lastname: Liu
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Fangyun
authors.initials: F
authors.lastname: Tian
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Santiago
authors.initials: S
authors.lastname: Rengifo
authors.affiliation: Chemistry.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Abhay
authors.initials: A
authors.lastname: Mathur
authors.affiliation: Departments of Molecular and Integrative Physiology.
authors.forename: Charles P
authors.initials: CP
authors.lastname: Crooks
authors.affiliation: Chemistry, Pharmacology.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Kennedy
authors.affiliation: Departments of Molecular and Integrative Physiology, Neurology, and Neuroscience Graduate Program, Cardiovascular Center, and Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI 48105.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Wang
authors.affiliation: Cardiovascular Center, and Internal Medicine-Cardiology, Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109; and.
authors.forename: Hamid
authors.initials: H
authors.lastname: Ghanbari
authors.affiliation: Departments of Molecular and Integrative Physiology, Neurology, and Neuroscience Graduate Program, Cardiovascular Center, and Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109; and borjigin@umich.edu.
authors.forename: Jimo
authors.initials: J
authors.lastname: Borjigin
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000503:physiopathology; D001237:Asphyxia / Q000150:complications* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004562:Electrocardiography; D004569:Electroencephalography; D005071:Evoked Potentials; D006321:Heart / Q000503:physiopathology*; D006323:Heart Arrest / Q000150:complications* / Q000503:physiopathology*; D006334:Heart Function Tests; D006339:Heart Rate; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D017208:Rats, Wistar; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000150:complications / Q000503:physiopathology
chemical_list: D018377:Neurotransmitter Agents
keywords: asphyxic cardiac arrest; autonomic nervous system; coherence; directed connectivity; near-death experience
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