title: Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly.
abstract: OBJECTIVE
  Elderly patients with gastrointestinal stromal tumors (GISTs) synchronous with other digestive tract malignancies have been rarely reported. In this study, clinicopathological characteristics were evaluated among elderly patients with GISTs with or without coexisting digestive tract malignancies.
  
  
  METHODS
  A total of 161 patients (≥65 years) were retrospectively reviewed at the West China Hospital, Sichuan University from January 2009 to June 2014.
  
  
  RESULTS
  Sixty-one patients were diagnosed with synchronous digestive tract malignancies (synchronous group), whereas 100 patients were diagnosed with no synchronous condition (no-synchronous group). The synchronous group exhibited a higher percentage of males (70.49% vs. 53.00%, P = 0.028) and poorer Eastern Cooperative Oncology Group performance status than the no-synchronous group (P = 0.029). The three-year overall survival (OS) rate was significantly lower among patients with synchronous digestive tract malignancies than that among patients without synchronous condition (64.5% vs. 84.0%, P = 0.003). Multivariate analysis showed that the presence of synchronous digestive tract malignancies (P = 0.002), co-morbidity (P = 0.004), and mitotic count ≥10 mitoses/50 high power fields (P = 0.012) were associated with poor OS.
  
  
  CONCLUSIONS
  A synchronous condition with other digestive tract malignancies is common in elderly patients with GISTs. OS primarily depends on synchronous digestive tract malignancies, mitotic count, and co-morbidity.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Chaoyong
authors.initials: C
authors.lastname: Shen
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Haining
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Jiaju
authors.initials: J
authors.lastname: Chen
authors.affiliation: Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Luyin
authors.initials: L
authors.lastname: Han
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Jiaping
authors.initials: J
authors.lastname: Chen
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: digestive tract malignancies; elderly; gastrointestinal stromal tumors; synchronous neoplasm
references.citation: World J Surg Oncol. 2014;12:25
references.pmid: 24479763
references.citation: World J Gastroenterol. 2009 Apr 28;15(16):2027-31
references.pmid: 19399938
references.citation: Int J Surg. 2014;12 Suppl 1:S145-7
references.pmid: 24859399
references.citation: Hum Pathol. 2008 Oct;39(10):1411-9
references.pmid: 18774375
references.citation: Lancet Oncol. 2012 Mar;13(3):265-74
references.pmid: 22153892
references.citation: J Gastroenterol Hepatol. 2005 Jun;20(6):818-24
references.pmid: 15946127
references.citation: J Gastroenterol. 2007 Aug;42(8):641-9
references.pmid: 17701127
references.citation: Turk J Gastroenterol. 2010 Sep;21(3):302-4
references.pmid: 20931437
references.citation: Chir Ital. 2008 Jan-Feb;60(1):135-9
references.pmid: 18389758
references.citation: World J Surg. 2010 Jul;34(7):1523-33
references.pmid: 20145924
references.citation: World J Gastroenterol. 2013 May 28;19(20):3117-23
references.pmid: 23716992
references.citation: Hum Pathol. 2006 Dec;37(12):1527-35
references.pmid: 16996566
references.citation: J Pak Med Assoc. 2006 Apr;56(4):184-6
references.pmid: 16711342
references.citation: Semin Diagn Pathol. 2006 May;23(2):120-9
references.pmid: 17193825
references.citation: J Clin Gastroenterol. 2002 Oct;35(4):332-4
references.pmid: 12352297
references.citation: Target Oncol. 2013 Dec;8(4):295-300
references.pmid: 23263874
references.citation: World J Gastroenterol. 2006 Sep 7;12(33):5360-2
references.pmid: 16981268
references.citation: Crit Rev Oncol Hematol. 2009 Jun;70(3):256-61
references.pmid: 18977152
references.citation: Tumour Biol. 2013 Apr;34(2):919-27
references.pmid: 23283817
references.citation: Intern Med. 2014;53(21):2483-8
references.pmid: 25366007
references.citation: World J Gastrointest Endosc. 2014 Jul 16;6(7):266-71
references.pmid: 25031785
references.citation: Oncologist. 2008;13 Suppl 2:4-7
references.pmid: 18434631
references.citation: Cancer. 2005 Feb 15;103(4):821-9
references.pmid: 15648083
references.citation: J Natl Compr Canc Netw. 2010 Apr;8 Suppl 2:S1-41; quiz S42-4
references.pmid: 20457867
references.citation: Am J Surg Pathol. 2010 Oct;34(10):1480-91
references.pmid: 20861712
references.citation: Leuk Res. 2010 Nov;34(11):1472-5
references.pmid: 20708799
references.citation: Arch Surg. 2009 Jul;144(7):670-8
references.pmid: 19620548
references.citation: Surg Endosc. 2008 Dec;22(12):2583-7
references.pmid: 18322738
references.citation: Br J Cancer. 2010 Jul 13;103(2):165-70
references.pmid: 20588273