title: Preemptive antiretroviral therapy modifications for the management of potential clinically significant drug interactions with direct acting hepatitis C therapies.
abstract: We report a case series of HIV/HCV co-infected patients who underwent preemptive antiretroviral therapy modifications to manage clinically significant drug interactions with HCV therapy. Among the 15 patients reviewed, all changed to a raltegravir-based regimen and none experienced a loss of virologic suppression or increase in HIV-RNA.
authors.affiliation: Departments of Pharmacy and Medicine, Upstate Medical University, Syracuse, NY, USA.
authors.forename: Megan
authors.initials: M
authors.lastname: Stambough
authors.affiliation: Departments of Pharmacy and Medicine, Upstate Medical University, Syracuse, NY, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Roman
authors.affiliation: Departments of Pharmacy and Medicine, Upstate Medical University, Syracuse, NY, USA.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Blair
authors.affiliation: Departments of Pharmacy and Medicine, Upstate Medical University, Syracuse, NY, USA.
authors.forename: Eric F
authors.initials: EF
authors.lastname: Sidman
authors.affiliation: Departments of Pharmacy and Medicine, Upstate Medical University, Syracuse, NY, USA millechr@upstate.edu.
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Miller
mesh_terms: D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D060085:Coinfection / Q000188:drug therapy*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D009518:New York; D012189:Retrospective Studies; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents
keywords: AIDS; HIV; antiretroviral therapy; boceprevir; drug interaction; hepatitis C; raltegravir; telaprevir; treatment; treatment switch