title: Bilaterally reduced claustral volumes in schizophrenia and major depressive disorder: a morphometric postmortem study.
abstract: Multiple brain structural abnormalities have been reported in schizophrenia and major depressive disorder. A majority of disease-affected brain regions act as relay nodes within neural networks, which are known to be impaired in neuropsychiatric diseases. One of these regions is the claustrum, which has the highest connectivity in the human brain by regional volume. Its possible involvement in disturbed connectivity is yet incompletely explored, however. The present study aimed at searching for possible structural deviations of the claustrum in neuropsychiatric disorders. We found bilaterally reduced claustral volumes both in schizophrenia and in major depressive disorder. These structural impairments may have different, disease-related consequences: In patients with schizophrenia, they may contribute to sensory processing impairments, and in patients with major depressive disorder to disturbances in salience.
authors.affiliation: Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany. Hans-Gert.Bernstein@med.ovgu.de.
authors.forename: Hans-Gert
authors.initials: HG
authors.lastname: Bernstein
authors.affiliation: Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Ortmann
authors.affiliation: Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany.
authors.forename: Henrik
authors.initials: H
authors.lastname: Dobrowolny
authors.affiliation: Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany.
authors.forename: Johann
authors.initials: J
authors.lastname: Steiner
authors.affiliation: Institute of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Ralf
authors.initials: R
authors.lastname: Brisch
authors.affiliation: Institute of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gos
authors.affiliation: Department of Psychiatry, Otto-von-Guericke-University, Leipziger Str. 44, 39120, Magdeburg, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Bogerts
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001479:Basal Ganglia / Q000473:pathology*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D012559:Schizophrenia / Q000473:pathology*; D012727:Sex Characteristics
keywords: Claustrum; MDD; Morphometry; Postmortem study; Schizophrenia
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