title: TNF-related apoptosis inducing ligand in ocular cancers and ocular diabetic complications.
abstract: TNF-related apoptosis inducing ligand (TRAIL) is an intensively studied cytokine, in particular for its anticancer activity. The discovery that conjunctival sac fluid contains extremely high levels of soluble TRAIL as compared to other body fluids suggested important implications in the context of the immunological surveillance of the eye, in particular of the anterior surface. In this review, we discuss the potential physiopathologic and therapeutic role of the TRAIL/TRAIL receptor system in a variety of ocular cancers. Moreover, since an increasing amount of data has indicated the important biological activities of the TRAIL/TRAIL receptor systems also in a completely different pathologic context such as diabetes mellitus, in the second part of this review we summarize the currently available data on the involvement of TRAIL in the ocular complications of diabetes mellitus as modulator of the inflammatory and angiogenic response in the eye.
authors.affiliation: Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Perri
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Zauli
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Arianna
authors.initials: A
authors.lastname: Gonelli
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Milani
authors.affiliation: Department of Life Sciences, University of Trieste, 34137 Trieste, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Celeghini
authors.affiliation: Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lamberti
authors.affiliation: Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44121 Ferrara, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Secchiero
mesh_terms: D017209:Apoptosis / Q000235:genetics; D048909:Diabetes Complications / Q000235:genetics* / Q000473:pathology; D003920:Diabetes Mellitus / Q000235:genetics / Q000473:pathology; D005134:Eye Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006801:Humans; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics*
chemical_list: D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human
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