title: [Ocular involvement with Candida albicans: report of 2 cases].
abstract: BACKGROUND
  Ocular involvement by Candida albicans is rare and may present as endogenous endophthalmitis or choroiditis. It occurs in the context of C. albicans septicemia, in the context of intensive care unit hospitalization or intravenous drug use. We report two cases referred to our department with different characteristics, background, diagnostic modalities and different courses.
  
  
  METHODS
  A 37-year-old woman, with a history of intravenous drug use, presented with C. albicans endophthalmitis. Intravenous combination antifungal therapy was begun, but vitrectomy and intravitreal amphotericin B were performed due to worsening of the endophthalmitis. The second case was a 53-year-old man who was hospitalized in the intensive care unit for C. albicans septicemia with a left macular chorioretinitis. Intravenous antifungal therapy was initiated and allowed regression of the ocular lesion.
  
  
  CONCLUSIONS
  Our cases illustrate both types of ophthalmic involvement by candidiasis requiring different treatments with well-described recommendations: in the case of endophthalmitis, the use of vitrectomy and intravitreal amphotericin B injection in association with intravenous antifungal treatment, whereas parenteral antifungal treatment is often sufficient in the case of chorioretinitis.
  
  
  CONCLUSIONS
  Early detection, initiation of treatment and ophthalmologic monitoring are difficult but necessary in these populations non-compliant with follow-up or in intensive care units. The management of ocular candidiasis requires good collaboration between the ophthalmology, infectious diseases and intensive care unit departments.
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France. Electronic address: srebika@chu-clermontferrand.fr.
authors.forename: S
authors.initials: S
authors.lastname: Rebika
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France; EA 7281 R2D2, biochemistry laboratory, medicine faculty, Auvergne university, 63000 Clermont-Ferrand, France.
authors.forename: N
authors.initials: N
authors.lastname: Bonnin
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France.
authors.forename: A
authors.initials: A
authors.lastname: Borel
authors.affiliation: RHEUNNIRS pole, infectious diseases department, Clermont-Ferrand university hospital, 63003 Clermont-Ferrand, France.
authors.forename: N
authors.initials: N
authors.lastname: Mrozek
authors.affiliation: RHEUNNIRS pole, infectious diseases department, Clermont-Ferrand university hospital, 63003 Clermont-Ferrand, France.
authors.forename: M
authors.initials: M
authors.lastname: Vidal
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France.
authors.forename: E
authors.initials: E
authors.lastname: Rousseau
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Bacin
authors.affiliation: RMND-M2O pole, ophthalmology department, Clermont-Ferrand university hospital, 63000 Clermont-Ferrand, France; EA 7281 R2D2, biochemistry laboratory, medicine faculty, Auvergne university, 63000 Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Chiambaretta
mesh_terms: D000328:Adult; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy; D002825:Chorioretinitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Candidemia; Candidose oculaire; Candidémie; Chorioretinitis; Endophtalmie; Endophthalmitis; Foyer choroïdien; Intensive care; Intravenous drug user; Ocular candidiasis; Réanimation; Toxicomanie intraveineuse