title: Integrating -Omics: Systems Biology as Explored Through C. elegans Research.
abstract: -Omics data have become indispensable to systems biology, which aims to describe the full complexity of functional cells, tissues, organs and organisms. Generating vast amounts of data via such methods, researchers have invested in ways of handling and interpreting these. From the large volumes of -omics data that have been gathered over the years, it is clear that the information derived from one -ome is usually far from complete. Now, individual techniques and methods for integration are maturing to the point that researchers can focus on network-based integration rather than simply interpreting single -ome studies. This review evaluates the application of integrated -omics approaches with a focus on Caenorhabditis elegans studies, intending to direct researchers in this field to useful databases and inspiring examples.
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Roel
authors.initials: R
authors.lastname: Van Assche
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Valérie
authors.initials: V
authors.lastname: Broeckx
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Kurt
authors.initials: K
authors.lastname: Boonen
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium; Flemish Institute for Technological Research (VITO), Boeretang 200, 2400 Mol, Belgium.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Maes
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: De Haes
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium.
authors.forename: Liliane
authors.initials: L
authors.lastname: Schoofs
authors.affiliation: Functional Genomics and Proteomics, Department of Biology, KU Leuven Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: liesbet.temmerman@bio.kuleuven.be.
authors.forename: Liesbet
authors.initials: L
authors.lastname: Temmerman
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology*; D019295:Computational Biology / Q000379:methods*; D016208:Databases, Factual; D049490:Systems Biology / Q000379:methods
keywords: -omics; C. elegans; integrating -omics; systems biology