title: Treatment of Periodontal Disease with an Octenidine-based Antiseptic in HIV-positive Patients.
abstract: OBJECTIVE
  To evaluate the effects of a periodontal therapy with subsequent application of an octenidine (OCT)-based antiseptic in HIV-positive patients receiving highly active antiretroviral therapy.
  
  
  METHODS
  HIV-positive patients with a clinically diagnosed periodontal disease were randomly divided into two groups (n = 30/group). Both groups initially received a periodontal therapy. Patients in the OCT group additionally used an OCT-based mouthwash. Subgingival plaque samples and periodontal indices were analysed prior to treatment onset as well as one and 3 months post-treatment.
  
  
  RESULTS
  Periodontal therapy has resulted in a significant decrease in the values of all periodontal indices one and 3 months following the therapy completion (P = 0.000). The effects of the two applied therapeutic protocols differed significantly in terms of the variation in the PBI (F = 4.617; P = 0.017) and the PD (F = 3.203; P = 0.044) value. In the patients in the OCT group, a more pronounced decrease in the PBI and PD was noted at 1-month follow-up as well as a greater increase in the PD value 3 months upon treatment completion. In the OCT group, no more atypical microorganisms were detectable 1 month post-treatment, while in the control group they were found in 34.5% of patients.
  
  
  CONCLUSIONS
  The periodontal therapy bears good results in HIV-positive patients. Additional administration of OCT contributes to the significant decline in the PBI and DS values and eliminates atypical microorganisms within 1 month post-treatment. However, more favourable results were not noted in the OCT group at the 3-month assessment.
authors.affiliation: Department of Periodontology and Oral Medicine, Clinic for Dentistry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: I
authors.initials: I
authors.lastname: Gušić
authors.affiliation: Institute of Public Health of Vojvodina, Centre for Microbiology, Novi Sad, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Medić
authors.affiliation: Miofarm Export-Import Ltd., Novi Sad, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Radovanović Kanjuh
authors.affiliation: Department of Periodontology and Oral Medicine, Clinic for Dentistry, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Ðurić
authors.affiliation: Clinic for Infectious Diseases, Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: S
authors.initials: S
authors.lastname: Brkić
authors.affiliation: Clinic for Infectious Diseases, Clinical Centre of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: V
authors.initials: V
authors.lastname: Turkulov
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: T
authors.initials: T
authors.lastname: Predin
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: J
authors.initials: J
authors.lastname: Mirnić
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D012534:Dental Scaling; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007097:Imines; D017622:Periodontal Attachment Loss / Q000628:therapy; D010510:Periodontal Diseases / Q000150:complications / Q000628:therapy*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy; D010518:Periodontitis / Q000628:therapy; D011725:Pyridines / Q000627:therapeutic use*; D016745:Root Planing
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; C034213:octenidine
keywords: HIV seropositivity; highly active antiretroviral therapy; octenidine; scaling and root planing