title: Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells.
abstract: Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells.
authors.affiliation: College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea; Department of Food Science, Gyeongnam National University of Science and Technology, Jinju 660-758, Republic of Korea.
authors.forename: Dahae
authors.initials: D
authors.lastname: Lee
authors.affiliation: Natural Product Research Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Ki Hyun
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea; Department of Chemistry, Gangneung Wonju National University, Gangneung 210-340, Republic of Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Moon
authors.affiliation: College of Dental Medicine, Gangneung Wonju National University, Gangneung 210-340, Republic of Korea.
authors.forename: Heesu
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea. Electronic address: kkang@gachon.ac.kr.
authors.forename: Ki Sung
authors.initials: KS
authors.lastname: Kang
authors.affiliation: Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea; Department of Biological Chemistry, University of Science and Technology (UST), Daejeon 305-333, Republic of Korea. Electronic address: jwlee5@kist.re.kr.
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D002945:Cisplatin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000166:cytology* / Q000187:drug effects*; D015394:Molecular Structure; D020011:Protective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine
chemical_list: D020011:Protective Agents; D002599:Chalcone; D002945:Cisplatin
keywords: Chalcone; Cisplatin-induced nephrotoxicity; MAPKs-p53-caspase-3; Renoprotection