title: Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechas L.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice.
abstract: We aimed in the present study to investigate the hepato- and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion+various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro- and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato- and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.
authors.affiliation: 1 Laboratory of Metabolic and Endocrine Aggressions Physiology, Department of Life Sciences, Faculty of Sciences of Tunis, Tunis, Tunisia .|2 Laboratory of Nutrition and Animal Physiology, Higher Institute of Biotechnology of Beja, Beja, Tunisia.
authors.forename: Slimen
authors.initials: S
authors.lastname: Selmi
authors.affiliation: 1 Laboratory of Metabolic and Endocrine Aggressions Physiology, Department of Life Sciences, Faculty of Sciences of Tunis, Tunis, Tunisia .
authors.forename: Manel
authors.initials: M
authors.lastname: Jallouli
authors.affiliation: 1 Laboratory of Metabolic and Endocrine Aggressions Physiology, Department of Life Sciences, Faculty of Sciences of Tunis, Tunis, Tunisia .
authors.forename: Najoua
authors.initials: N
authors.lastname: Gharbi
authors.affiliation: 2 Laboratory of Nutrition and Animal Physiology, Higher Institute of Biotechnology of Beja, Beja, Tunisia.
authors.forename: Lamjed
authors.initials: L
authors.lastname: Marzouki
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000032:analysis; D007306:Insecticides; D007668:Kidney / Q000737:chemistry / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D027523:Lavandula / Q000737:chemistry*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008294:Malathion / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051379:Mice; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D013482:Superoxide Dismutase / Q000378:metabolism; D014416:Tunisia
chemical_list: D007306:Insecticides; D009822:Oils, Volatile; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008294:Malathion
keywords: Lavandula stoechas; essential oils; kidney; liver; malathion; mice; oxidative stress
references.citation: Biochem Pharmacol. 1990 Jun 1;39(11):1647-55
references.pmid: 2344365
references.citation: Environ Health Perspect. 1994 Jan;102(1):18-38
references.pmid: 9719666
references.citation: QJM. 2000 Nov;93(11):715-31
references.pmid: 11077028
references.citation: Toxicology. 2007 Mar 7;231(2-3):137-46
references.pmid: 17197067
references.citation: Biochem J. 2001 Apr 1;355(Pt 1):145-53
references.pmid: 11256959
references.citation: Pharmazie. 1987 Oct;42(10):706-7
references.pmid: 3438332
references.citation: C R Biol. 2008 Sep;331(9):655-62
references.pmid: 18722984
references.citation: Environ Toxicol Pharmacol. 2012 Nov;34(3):753-60
references.pmid: 23122842
references.citation: Toxicol Ind Health. 2015 Sep;31(9):783-8
references.pmid: 23344821
references.citation: Evid Based Complement Alternat Med. 2012;2012:837939
references.pmid: 22991573
references.citation: Reprod Toxicol. 2000 Sep-Oct;14(5):457-62
references.pmid: 11020656
references.citation: Evid Based Complement Alternat Med. 2013;2013:681304
references.pmid: 23573142
references.citation: Ann Biol Clin (Paris). 1975;33(1):3-13
references.pmid: 1190573
references.citation: Methods Enzymol. 1984;105:121-6
references.pmid: 6727660
references.citation: Int J Mol Sci. 2014;15(9):15638-78
references.pmid: 25192288
references.citation: Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G1004-13
references.pmid: 12791596
references.citation: Toxicology. 2006 Jul 5;224(1-2):22-32
references.pmid: 16757081
references.citation: Gen Comp Endocrinol. 2015 May 1;215:88-97
references.pmid: 25449180
references.citation: Toxicol Mech Methods. 2010 Nov;20(9):538-43
references.pmid: 20919798
references.citation: J Ethnopharmacol. 2014 Mar 14;152(2):327-32
references.pmid: 24463157
references.citation: Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10316-20
references.pmid: 1332045
references.citation: J Clin Invest. 1995 Sep;96(3):1414-24
references.pmid: 7657814
references.citation: Food Chem Toxicol. 2009 Aug;47(8):1903-8
references.pmid: 19442699
references.citation: J Med Food. 2015 Feb;18(2):241-9
references.pmid: 25105335
references.citation: Am J Clin Nutr. 1996 Jun;63(6):985S-990S
references.pmid: 8644698
references.citation: J Ethnopharmacol. 2008 Feb 28;116(1):64-73
references.pmid: 18063331
references.citation: J Biol Chem. 1972 May 25;247(10):3170-5
references.pmid: 4623845
references.citation: Complement Ther Clin Pract. 2011 Feb;17(1):50-3
references.pmid: 21168115
references.citation: Food Chem Toxicol. 2010 Feb;48(2):633-8
references.pmid: 19941925
references.citation: Toxicology. 2009 May 2;259(1-2):1-9
references.pmid: 19167454
references.citation: Methods Enzymol. 1978;52:302-10
references.pmid: 672633
references.citation: Chem Res Toxicol. 1996 Jan-Feb;9(1):247-54
references.pmid: 8924599
references.citation: J Ethnopharmacol. 2003 Nov;89(1):67-71
references.pmid: 14522434
references.citation: Lipids Health Dis. 2013;12:189
references.pmid: 24373672
references.citation: Food Chem Toxicol. 2013 Nov;61:152-9
references.pmid: 23712099
references.citation: Anal Biochem. 1976 May 7;72:248-54
references.pmid: 942051
references.citation: J Med Food. 2014 Jul;17(7):782-6
references.pmid: 24611963
references.citation: Methods Enzymol. 1984;105:114-21
references.pmid: 6727659
references.citation: Pharmacol Biochem Behav. 1996 Aug;54(4):731-7
references.pmid: 8853197
references.citation: J Tradit Complement Med. 2014 Oct;4(4):253-7
references.pmid: 25379467
references.citation: Curr Opin Lipidol. 2001 Feb;12(1):41-8
references.pmid: 11176202