title: Progressive outer retinal necrosis in a renal transplant recipient: a rare treatment success.
abstract: Renal transplant recipients (RTRs) are subject to a variety of opportunistic infections. We present a rare case of varicella zoster virus-derived progressive outer retinal necrosis in an RTR, who presented with painless visual blurring. This clinical entity heralds an extremely poor visual prognosis and is an important condition to consider in any immunocompromised host. Early diagnosis by aqueous fluid sampling and immediate institution of combined systemic and intravitreal antiviral therapy was successful in this individual.
authors.affiliation: Department of Medicine, Queen Mary Hospital, Hong Kong, China.
authors.forename: G C W
authors.initials: GC
authors.lastname: Chan
authors.affiliation: Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: D Y H
authors.initials: DY
authors.lastname: Yap
authors.affiliation: Department of Medicine, Queen Mary Hospital, Hong Kong, China.
authors.forename: L P Y
authors.initials: LP
authors.lastname: Kwan
authors.affiliation: Department of Microbiology, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, China.
authors.forename: J F W
authors.initials: JF
authors.lastname: Chan
authors.affiliation: Ophthalmology Department, Queen Mary Hospital, Hong Kong, China.
authors.forename: L P
authors.initials: LP
authors.lastname: Iu
authors.affiliation: Ophthalmology Department, Queen Mary Hospital, Hong Kong, China.
authors.forename: I Y
authors.initials: IY
authors.lastname: Wong
authors.affiliation: Division of Nephrology, Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors.forename: S C W
authors.initials: SC
authors.lastname: Tang
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D058449:Intravitreal Injections; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D009336:Necrosis; D012173:Retinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir
keywords: progressive outer retinal necrosis; renal transplantation; varicella zoster virus