title: Mouse models of metabolic liver injury.
abstract: Metabolic liver injury is one of the fastest growing health problems worldwide. Alcoholic and non-alcoholic fatty livers have been shown to be associated with progression to end-stage liver diseases, as well as to liver cancers, in humans. More importantly, there are no validated therapies for these disorders, therefore intensive research is required in this area. This review of standard operation procedures focuses on the experimental models of fatty liver disease in the mouse. Firstly, use of these experimental models might improve understanding of underlying mechanisms, and secondly this might help to test potential therapeutic options. This article includes, besides a short historic background, an insight into the pathobiochemical mechanisms and detailed experimental procedures as well as the practical implementation of these models.
authors.affiliation: Department of Internal Medicine III, RWTH University Hospital Aachen, Aachen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Ramadori
authors.affiliation: Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University, Aachen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Weiskirchen
authors.affiliation: Department of Internal Medicine I, University of Bonn, Bonn, Germany jonel.trebicka@ukb.uni-bonn.de kstreetz@ukaachen.de.
authors.forename: J
authors.initials: J
authors.lastname: Trebicka
authors.affiliation: Department of Internal Medicine III, RWTH University Hospital Aachen, Aachen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Streetz
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D017408:Guidelines as Topic; D006801:Humans; D007756:Laboratory Animal Science / Q000592:standards; D051379:Mice
keywords: Lieber-DeCarli; MCD; NAFLD; NASH; fat; inflammation; steatosis