title: Inflammatory bowel disease pathogenesis: where are we?
abstract: Inflammatory bowel disease (IBD) is presently one of the most investigated human disorders. Expansion of knowledge of its pathophysiology has helped in developing novel medications to combat gut inflammation with a considerably degree of success. Despite this progress, much more remains to be done in regard to gaining a more profound understanding of IBD pathogenesis, detecting inflammation before it clinically manifests, implementing lifestyle modifications, and developing agents that can modify the natural course of the disease. One of the limitations to achieve these goals is the lack of integration of the major components of IBD pathogenesis, that is the exposome, the genome, the gut microbiome, and the immunome. An "IBD integrome" approach that takes advantage of all functional information derived from the detailed investigation of each single pathogenic component through the use of systems biology may offer the solution to understand IBD and cure it.
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: Claudio
authors.initials: C
authors.lastname: Fiocchi
mesh_terms: D000818:Animals; D015551:Autoimmunity; D004195:Disease Models, Animal; D015894:Genome, Human / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000209:etiology*; D007422:Intestines / Q000382:microbiology; D008019:Life Style; D051379:Mice; D064307:Microbiota; D058990:Molecular Targeted Therapy; D013997:Time Factors
keywords: Crohn's disease; inflammatory bowel disease; integrome; pathogenesis; ulcerative colitis