title: Juxtamembrane contribution to transmembrane signaling.
abstract: Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single-span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the transmembrane helix with the rest of the cytoplasmic domain participates directly in the signaling process via several novel mechanisms. This review briefly highlights several modes of JM dynamics in the context of signal transduction that are shared by different types of transmembrane receptors.
authors.affiliation: Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, 30322.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, GA, 30322.
authors.forename: Renhao
authors.initials: R
authors.lastname: Li
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface
keywords: juxtamembrane; proteinlipid interaction; signal transduction; transmembrane receptor
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):703-8
references.pmid: 20080739
references.citation: Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16524-9
references.pmid: 20813958
references.citation: Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22481-6
references.pmid: 21156831
references.citation: J Biol Chem. 2011 Mar 18;286(11):9577-86
references.pmid: 21220419
references.citation: Blood. 2011 Jun 2;117(22):6012-23
references.pmid: 21464369
references.citation: J Immunol. 2011 Jun 15;186(12):6839-47
references.pmid: 21543646
references.citation: Annu Rev Biochem. 2011;80:211-37
references.pmid: 21548783
references.citation: FASEB J. 2011 Jul;25(7):2234-44
references.pmid: 21402716
references.citation: Annu Rev Cell Dev Biol. 2011;27:321-45
references.pmid: 21663444
references.citation: Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19323-8
references.pmid: 22084078
references.citation: Nature. 2012 Jan 12;481(7380):209-13
references.pmid: 22178926
references.citation: J Clin Endocrinol Metab. 2001 Apr;86(4):1716-23
references.pmid: 11297608
references.citation: J Biol Chem. 2002 May 24;277(21):18801-9
references.pmid: 11844795
references.citation: Mol Biol Cell. 2002 Jul;13(7):2547-57
references.pmid: 12134089
references.citation: Biochemistry. 2002 Dec 31;41(52):15618-24
references.pmid: 12501190
references.citation: FEBS Lett. 2003 Mar 13;538(1-3):113-6
references.pmid: 12633863
references.citation: Mol Cell. 2003 Sep;12(3):541-52
references.pmid: 14527402
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4094-9
references.pmid: 15024114
references.citation: Nat Rev Mol Cell Biol. 2004 Jun;5(6):464-71
references.pmid: 15173825
references.citation: J Biol Chem. 2012 Aug 3;287(32):26513-27
references.pmid: 22711531
references.citation: J Biol Chem. 2012 Sep 7;287(37):31515-26
references.pmid: 22822084
references.citation: PLoS One. 2012;7(11):e48875
references.pmid: 23155421
references.citation: J Biol Chem. 2012 Dec 21;287(52):43810-24
references.pmid: 23105112
references.citation: J Biol Chem. 2004 Jun 18;279(25):26666-73
references.pmid: 15067009
references.citation: Cell. 1986 Jun 6;45(5):649-57
references.pmid: 2871941
references.citation: Biochemistry. 1987 Mar 10;26(5):1434-42
references.pmid: 3494472
references.citation: Biochemistry. 1987 Mar 10;26(5):1443-51
references.pmid: 3494473
references.citation: EMBO J. 1992 Mar;11(3):923-32
references.pmid: 1347745
references.citation: J Biol Chem. 1993 Jul 15;268(20):15229-37
references.pmid: 7686912
references.citation: J Biol Chem. 1994 Nov 11;269(45):28214-9
references.pmid: 7961759
references.citation: Nat Struct Biol. 1996 Mar;3(3):252-8
references.pmid: 8605627
references.citation: J Biol Chem. 1996 Mar 22;271(12):6571-4
references.pmid: 8636068
references.citation: Curr Opin Chem Biol. 1999 Feb;3(1):95-9
references.pmid: 10021405
references.citation: Science. 1999 Sep 10;285(5434):1751-4
references.pmid: 10481014
references.citation: Exp Hematol. 2005 Jan;33(1):85-93
references.pmid: 15661401
references.citation: Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1424-9
references.pmid: 15671157
references.citation: J Gen Physiol. 2005 Jul;126(1):41-53
references.pmid: 15955874
references.citation: J Biol Chem. 2005 Dec 30;280(52):42573-9
references.pmid: 16253987
references.citation: Blood. 2006 Mar 1;107(5):1864-71
references.pmid: 16249382
references.citation: J Biol Chem. 2006 Mar 17;281(11):7002-11
references.pmid: 16414957
references.citation: J Biol Chem. 2006 Aug 11;281(32):22744-51
references.pmid: 16774916
references.citation: Cell. 2006 Sep 8;126(5):929-40
references.pmid: 16959572
references.citation: Cell. 2006 Nov 3;127(3):447-50
references.pmid: 17081964
references.citation: Science. 2006 Dec 1;314(5804):1458-61
references.pmid: 17095657
references.citation: Biochemistry. 2006 Dec 26;45(51):15731-9
references.pmid: 17176095
references.citation: J Biol Chem. 2007 May 11;282(19):14253-61
references.pmid: 17369254
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20782-7
references.pmid: 18093920
references.citation: Curr Opin Struct Biol. 2008 Aug;18(4):412-9
references.pmid: 18539023
references.citation: J Mol Biol. 2008 Oct 3;382(2):448-57
references.pmid: 18674540
references.citation: Cell. 2008 Nov 14;135(4):702-13
references.pmid: 19013279
references.citation: EMBO J. 2009 May 6;28(9):1351-61
references.pmid: 19279667
references.citation: Cell. 2009 Jun 26;137(7):1293-307
references.pmid: 19563760
references.citation: Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17729-34
references.pmid: 19805198
references.citation: EMBO J. 2009 Nov 18;28(22):3623-32
references.pmid: 19798053
references.citation: Nature. 2013 Jan 3;493(7430):111-5
references.pmid: 23201688
references.citation: Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1646-51
references.pmid: 23319611
references.citation: Cell. 2013 Jan 31;152(3):543-56
references.pmid: 23374349
references.citation: Cell. 2013 Jan 31;152(3):557-69
references.pmid: 23374350
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2540-5
references.pmid: 23359689
references.citation: PLoS One. 2013;8(5):e62861
references.pmid: 23658780
references.citation: J Mol Biol. 2013 Sep 23;425(18):3549-62
references.pmid: 23796515
references.citation: Science. 2014 May 16;344(6185):1249783
references.pmid: 24833397
references.citation: Biochemistry. 2014 Aug 5;53(30):5000-7
references.pmid: 25010350
references.citation: Int J Cancer. 2014 Dec 1;135(11):2547-57
references.pmid: 24740739
references.citation: Trends Biochem Sci. 2014 Oct;39(10):437-46
references.pmid: 25242369
references.citation: Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15987-92
references.pmid: 25349418
references.citation: J Biol Chem. 2014 Dec 19;289(51):35159-71
references.pmid: 25359776
references.citation: PLoS One. 2015;10(1):e0116368
references.pmid: 25565389
references.citation: J Biol Chem. 2000 Mar 17;275(11):7839-53
references.pmid: 10713099
references.citation: Semin Immunol. 2000 Feb;12(1):23-34
references.pmid: 10723795
references.citation: Cell. 2000 Oct 13;103(2):211-25
references.pmid: 11057895
references.citation: Nat Struct Biol. 2000 Nov;7(11):1023-6
references.pmid: 11062556
references.citation: Biochemistry. 2001 Feb 6;40(5):1358-66
references.pmid: 11170463
references.citation: Mol Cell. 2001 Feb;7(2):377-85
references.pmid: 11239466
references.citation: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4379-84
references.pmid: 11296286