title: Gold mining for PDT: Great expectations from tiny nanoparticles.
abstract: Among many and various products, born by the modern nanotechnology, gold nanoparticles roused a special interest of biomedical researchers. Unique features of the nanoparticles allow to use them not only as effective transporters for therapeutic agents but also as basic components of nanocomposite preparations intended for targeted photodynamic and photothermal therapy of tumours. In the review, physical, chemical and biological properties of gold nanoparticles which can promote PDT efficiency of a designed nanocomposite, are briefly characterized, and promising trends in creation of gold-containing composite photosensitizers are analysed.
authors.affiliation: Laboratory of Quantum Nanobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv 03022, Ukraine. Electronic address: gamaleia@onconet.kiev.ua.
authors.forename: Nikolai F
authors.initials: NF
authors.lastname: Gamaleia
authors.affiliation: Laboratory of Quantum Nanobiology, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, 45 Vasylkivska Str., Kyiv 03022, Ukraine.
authors.forename: Irina O
authors.initials: IO
authors.lastname: Shton
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D002463:Cell Membrane Permeability; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D004337:Drug Carriers; D036341:Intercellular Signaling Peptides and Proteins; D017319:Photosensitizing Agents; D006046:Gold
keywords: Nanogold; Nanoparticles; Photodynamic therapy; Photosensitizers