title: [Cytogenetical alterations in the workers of higher chemical hazard enterprises in accordance with duration of the employment period].
abstract: Cytogenetical examination was performed in 135 workers of higher chemical hazard enterprises with the duration of the employment period from 1 to 23 years. Weak, but statistically significant correlations were observed between indices: the total rate of chromosome aberrations (CA) (Tau = 0.14, p < 0.05), the rate of single fragments (Tau = 0.12, p = 0.01), the rate of ring chronosomes (Tau= 0.12, p = 0.04), the rate of double fragments (Tau = 0.13, p = 0.02), the rate of chromosomal exchange aberrations of chromosome type (Tau = 0.13, p < 0.03) and "the rate of multiaberrant metaphases" (Tau = 0.2, p = 0.0008) and the duration of the employment period at the higher chemical hazard enterprises. The rates of all types of CA was significantly higher in the group with duration of the employment period more than 5 years the significant exceedance of the control level was observed only for the total rate of CA and the rate of single fragments. Other CA types do not significantly exceed control indices. The ratio of carriers of CA of exchange type in the long standing group was significantly higher than in the short standing group, in that ring chromosomes were observed in the long standing group. Differences in the ratio of persons with the normal and increased levels of CA were statistically significant.
authors.forename: T V
authors.initials: TV
authors.lastname: Kharchenko
authors.forename: L G
authors.initials: LG
authors.lastname: Arzhavkina
authors.forename: D A
authors.initials: DA
authors.lastname: Sinyachkin
authors.forename: A V
authors.initials: AV
authors.lastname: Yazenok
mesh_terms: D016022:Case-Control Studies; D002869:Chromosome Aberrations / Q000139:chemically induced* / Q000706:statistics & numerical data; D015331:Cohort Studies; D020732:Cytogenetic Analysis; D004305:Dose-Response Relationship, Drug; D004651:Employment; D015386:Hazardous Substances / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D007221:Industry; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D012307:Risk Factors; D012426:Russia; D013997:Time Factors
chemical_list: D015386:Hazardous Substances