title: Formulation of rizatriptan benzoate fast dissolving buccal films by emulsion evaporation technique.
abstract: OBJECTIVE
  The present study deals with the formulation of fast dissolving films of Rizatriptan benzoate that is used for the treatment of Migraine. The concept of fast-dissolving drug delivery emerged from the desire to provide patient with more conventional means of taking their medication.
  
  
  METHODS
  In the present research work, various trials were carried out using film forming agents such as maltodextrin, gum karaya and xanthan gum to prepare an ideal film. Emulsion evaporation method was used for the preparation of films. The prepared films were evaluated for weight uniformity, drug content, film thickness, folding endurance, dispersion test and curling. The in vitro dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate buffer).
  
  
  RESULTS
  About 97% of the drug was found to be released from the film within 10 min that is a desirable character for fast absorption. The drug excipient interaction studies carried out by differential scanning calorimetry analysis and Fourier transform infrared studies revealed that there were no major interactions between the drugs and excipients used for the preparation of films.
  
  
  CONCLUSIONS
  Fast dissolving films of Rizatriptan benzoate prepared by emulsion evaporation technique were found to be suitable for eliciting better therapeutic effect in the treatment of migraine.
authors.affiliation: Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.
authors.forename: Suryadevara
authors.initials: S
authors.lastname: Vidyadhara
authors.affiliation: Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.
authors.forename: Reddyvallam Lankapalli
authors.initials: RL
authors.lastname: Sasidhar
authors.affiliation: Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.
authors.forename: Thalamanchi
authors.initials: T
authors.lastname: Balakrishna
authors.affiliation: Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.
authors.forename: Malapolu Santha
authors.initials: MS
authors.lastname: Vardhan
keywords: Emulsion evaporation method; fast dissolving films; gum karaya; maltodextrin; rizatriptan benzoate; xanthan gum
references.citation: Indian J Pharm Sci. 2008 Mar-Apr;70(2):175-9
references.pmid: 20046708
references.citation: Int J Pharm Investig. 2011 Apr;1(2):99-104
references.pmid: 23071928
references.citation: Materials (Basel). 2010 Aug 09;3(8):4291-4299
references.pmid: 28883330
references.citation: J Pharm Pharmacol. 1998 Apr;50(4):375-82
references.pmid: 9625481