title: Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids.
abstract: BACKGROUND
  The colon plays a key role in regulating the homeostasis of bile acids.
  
  
  OBJECTIVE
  The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids.
  
  
  METHODS
  The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments.
  
  
  RESULTS
  The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p<0.001).
  
  
  CONCLUSIONS
  The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Duan
authors.initials: D
authors.lastname: Dongfeng
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: An
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shujia
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Jikai
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Rui
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Tan
authors.initials: T
authors.lastname: Kai
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Yafeng
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Jianguo
authors.affiliation: Department of general surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, PR China.
authors.forename: Du
authors.initials: D
authors.lastname: Xilin
mesh_terms: D000368:Aged; D001647:Bile Acids and Salts / Q000097:blood*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003110:Colonic Neoplasms / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001647:Bile Acids and Salts
keywords: Colon cancer; conjugated bile acids; free bile acids
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