title: Prolidase activity and oxidative stress in patients with schizophrenia: a preliminary study.
abstract: OBJECTIVE
  To determine whether serum prolidase levels are associated with the etiopathogenesis of schizophrenia.
  
  
  METHODS
  The study was conducted at the psychiatry outpatient clinics of the University Hospitals of Recep Tayyip Erdogan and Afyonkocatepe in spring 2013. It comprised patients with schizophrenia who were consecutively recruited from the Psychiatry outpatient clinics of the hospital. An equal number of healthy individuals were recruited from the community. Each patient underwent a detailed diagnostic evaluation by psychiatry residents by using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV. Serum prolidase activity and oxidative parameters were measured in patient and control groups.The severity of psychotic symptoms was assessed using the positive and negative syndrome scale. SPSS 16 was used for statitistical analysis.
  
  
  RESULTS
  There were 30 subjects in each group, with 18 (60%) females among the patients and 21 (70%) among the controls. Serum prolidase level was significantly higher in schizophrenia patients compared to the controls (p < 0.001). Total Oxidative Stress and Oxidative Stress Index parameters were found to be significantly different between the patients and the controls (p = 0.024 and p < 0.001). Serum prolidase level did not show any correlation with markers of oxidative stress in the patients.
  
  
  CONCLUSIONS
  Prolidase activity, glutamate transmission and oxidative stress may be inter-related in the etiopathogenesis of schizophrenia.
authors.forename: Bulent
authors.initials: B
authors.lastname: Bahceci
authors.forename: Erman
authors.initials: E
authors.lastname: Bagcioglu
authors.forename: Mehmet Hanefi
authors.initials: MH
authors.lastname: Kokacya
authors.forename: Aziz Ramazan
authors.initials: AR
authors.lastname: Dilek
authors.forename: Ilkay
authors.initials: I
authors.lastname: Bahceci
authors.forename: Salih
authors.initials: S
authors.lastname: Selek
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004150:Dipeptidases / Q000378:metabolism*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D012559:Schizophrenia / Q000201:enzymology* / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D055815:Young Adult
chemical_list: D018698:Glutamic Acid; D004150:Dipeptidases; C022449:proline dipeptidase