title: Interleukin-8 -251A/T gene polymorphism and lung cancer susceptibility: a meta-analysis.
abstract: Many studies have examined the association between the interleukin-8 -251T/A (rs4073) gene polymorphism and lung cancer risk in various populations, but the results have been inconsistent. In this meta-analysis, PubMed was searched for case-control studies published through 01 December 2013. The data were extracted, and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. We assessed six published studies on the association between the interleukin-8 -251T/A polymorphism and lung cancer risk. The included studies yielded a total of 3265 lung cancer cases and 3607 controls. For the homozygous A/A and A allele carriers (T/A + A/A), the pooled ORs for all studies combining 3265 cases and 3607 controls were 1.03 (95% CI = 0.92-1.14; P = 0.235 for heterogeneity) and 1.07 (95% CI = 0.96-1.19; P = 0.245 for heterogeneity) when compared with the homozygous wild-type genotype (T/T). When the analysis was stratified by ethnicity, significant risks were found among Asians for both the A allele carriers and the homozygous A/A individuals. However, no significant associations were found in non-Asian populations using any of the genetic models. This meta-analysis suggests that the interleukin-8 -251A allele confer an increased risk for the development of lung cancer among Asians.
authors.affiliation: Department of Thoracic Cardiovascular Surgery, Inner Mongolia Forestry General Hospital, Yakeshi, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China.
authors.forename: Yun-Song
authors.initials: YS
authors.lastname: Li
authors.affiliation: Department of Oncology, Beijing Chest Hospital, Capital Medical University, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8
keywords: Interleukin-8; lung cancer; meta-analysis; polymorphism; susceptibility
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