title: Roles of kinins in the nervous system.
abstract: The kallikrein-kinin system (KKS) is an endogenous pathway involved in many biological processes. Although primarily related to blood pressure control and inflammation, its activation goes beyond these effects. Neurogenesis and neuroprotection might be stimulated by bradykinin being of great interest for clinical applications following brain injury. This peptide is also an important player in spinal cord injury pathophysiology and recovery, in which bradykinin receptor blockers represent substantial therapeutic potential. Here, we highlight the participation of kinin receptors and especially bradykinin in mediating ischemia pathophysiology in the central and peripheral nervous systems. Moreover, we explore the recent advances on mechanistic and therapeutic targets for biological, pathological, and neural repair processes involving kinins.
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
authors.forename: Priscilla D
authors.initials: PD
authors.lastname: Negraes
authors.forename: Cleber A
authors.initials: CA
authors.lastname: Trujillo
authors.forename: Micheli M
authors.initials: MM
authors.lastname: Pillat
authors.forename: Yang D
authors.initials: YD
authors.lastname: Teng
authors.forename: Henning
authors.initials: H
authors.lastname: Ulrich
mesh_terms: D000818:Animals; D006801:Humans; D007705:Kinins / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism*; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis; D018002:Receptors, Bradykinin / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000503:physiopathology
chemical_list: D007705:Kinins; D018002:Receptors, Bradykinin