title: Challenges of ionizing radiation in tumor treatment and role of angiogenesis.
abstract: Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply. Rapid growing tumors cause hypoxia that upregulates many pro-survival pathways. At clinical doses, radiation activates inflammatory pathways and causes oxidative stress that plays a positive role during angiogenesis. Selective targeting of signaling mechanisms may radiosensitize tumors.
authors.forename: Subir Kumar
authors.initials: SK
authors.lastname: Das
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000276:immunology / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology* / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000532:radiotherapy*; D010100:Oxygen / Q000276:immunology*; D011839:Radiation, Ionizing; D020266:Radiotherapy, Conformal / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D010100:Oxygen