title: Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression.
abstract: The aim of the present study was to investigate the effect of different resistance-training regimens (S or P) on the expression of genes related to the MSTN signaling pathway in physically-active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n=11) or a power-training group (P; n=11). The control group (C; n=7) was composed of healthy physically-active males. The S and the P groups performed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3 A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST (S: 4.2 fold induction and P: 3.7 fold induction, p<0.01) and FL-3 (S: 5.6 fold induction and P: 5.6 fold induction, p<0.01), was detected after the training period. SMAD-7 gene expression was similarly augmented after both training protocols (S: 2.5 fold induction; P: 2.8 fold induction; p<0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner.
authors.affiliation: School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Santos
authors.affiliation: School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Lamas
authors.affiliation: School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors.forename: C
authors.initials: C
authors.lastname: Ugrinowitsch
authors.affiliation: School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Tricoli
authors.affiliation: Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: E H
authors.initials: EH
authors.lastname: Miyabara
authors.affiliation: Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
authors.forename: A G
authors.initials: AG
authors.lastname: Soares
authors.affiliation: School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Aoki
mesh_terms: D000328:Adult; D001706:Biopsy; D015870:Gene Expression; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism*; D055435:Myostatin / Q000235:genetics* / Q000378:metabolism; D010806:Physical Education and Training / Q000379:methods*; D060888:Real-Time Polymerase Chain Reaction; D055070:Resistance Training / Q000379:methods*; D015398:Signal Transduction; D055815:Young Adult
chemical_list: C525911:MSTN protein, human; D055435:Myostatin