title: Repertoires of autophagy in the pathogenesis of ocular diseases.
abstract: Autophagy is an important intracellular degradative process that delivers cytoplasmic proteins to lysosome for degradation. Dysfunction of autophagy is implicated in several human diseases, such as neurodegenerative diseases, infectious diseases, and cancers. Autophagy-related proteins are constitutively expressed in the eye. Increasing studies have revealed that abnormal autophagy is an important pathological feature of several ocular diseases. Pharmacological manipulation of autophagy may provide an alternative therapeutic target for some ocular diseases. In this manuscript, we reviewed the relevant progress about the role of autophagy in the pathogenesis of ocular diseases.
authors.affiliation: Eye Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Li
authors.forename: Qin
authors.initials: Q
authors.lastname: Jiang
authors.forename: Guo-fan
authors.initials: GF
authors.lastname: Cao
authors.forename: Jin
authors.initials: J
authors.lastname: Yao
authors.forename: Biao
authors.initials: B
authors.lastname: Yan
mesh_terms: D001343:Autophagy; D002386:Cataract / Q000378:metabolism / Q000473:pathology; D003930:Diabetic Retinopathy / Q000378:metabolism / Q000473:pathology; D005128:Eye Diseases / Q000378:metabolism / Q000473:pathology*; D005901:Glaucoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008268:Macular Degeneration / Q000378:metabolism / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000378:metabolism; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D025521:Tumor Suppressor Proteins