title: HER2 expression in gastric and oesophageal cancer: a meta-analytic review.
abstract: BACKGROUND
  Since the advent and the success of adjuvant medical therapy for human epidermal growth factor receptor 2 (HER2)-positive breast cancer in the form of trastuzumab there has been increasing interest in the development of similar therapies in other solid organ malignancies including gastric cancer and oesophageal cancer. Over the years, multiple observational studies have been inconsistent. Several meta-analyses have been published looking at the association between HER2 and gastric cancer and oesophageal cancer. This review aims to summarize the meta-analytic evidence for the association between HER2 in gastric and oesophageal cancer.
  
  
  METHODS
  A systematic search was conducted using MEDLINE, PubMed, EMBASE, Current Contents Connect, Cochrane Library, Google Scholar, Science Direct, and Web of Science.
  
  
  RESULTS
  Of the articles selected, only nine studies met full criteria. Six of them reviewed the role of HER2 in gastric cancer and the remaining three reviewed its role in oesophageal cancer.
  
  
  CONCLUSIONS
  The current evidence regarding the role of HER2 is unclear. However, it clearly plays a key role in the pathogenesis of gastric and oesophageal carcinomas. Targeted therapy towards this subgroup (despite variable frequency and association with survival) would offer a mortality benefit and improve survival.
authors.affiliation: The Whiteley-Martin Research Centre, Discipline of Surgery, The Sydney Medical School Nepean, Penrith, NSW 2751, Australia.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Nagaraja
authors.affiliation: The Whiteley-Martin Research Centre, Discipline of Surgery, The Sydney Medical School Nepean, Penrith, NSW 2751, Australia.
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
keywords: Human epidermal growth factor receptor 2 (HER2); esophageal cancer; gastric cancer
references.citation: Asian Pac J Cancer Prev. 2014;15(14):5551-6
references.pmid: 25081663
references.citation: J Zhejiang Univ Sci B. 2014 Jun;15(6):582-9
references.pmid: 24903996
references.citation: Asian Pac J Cancer Prev. 2011;12(6):1417-23
references.pmid: 22229170
references.citation: Am J Clin Pathol. 2009 Oct;132(4):539-48
references.pmid: 19762531
references.citation: Asian Pac J Cancer Prev. 2014;15(13):5343-8
references.pmid: 25040999
references.citation: Appl Immunohistochem Mol Morphol. 2014;22(2):146-52
references.pmid: 23702645
references.citation: Int J Cancer. 2012 Jun 15;130(12):2845-56
references.pmid: 21780108
references.citation: Control Clin Trials. 1986 Sep;7(3):177-88
references.pmid: 3802833
references.citation: CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
references.pmid: 15761078
references.citation: Tumour Biol. 2014 Jun;35(6):5315-21
references.pmid: 24557541
references.citation: Gynecol Oncol. 2014 Nov;135(2):364-70
references.pmid: 25220628
references.citation: J Gastrointest Oncol. 2014 Feb;5(1):25-35
references.pmid: 24490040
references.citation: Oncologist. 2011;16(12):1706-13
references.pmid: 22143936
references.citation: J Cancer. 2012;3:137-44
references.pmid: 22481979
references.citation: J Urol. 2010 Sep;184(3):842-50
references.pmid: 20663525
references.citation: Histopathology. 2008 Jun;52(7):797-805
references.pmid: 18422971
references.citation: Tumour Biol. 2014 May;35(5):4849-58
references.pmid: 24449506
references.citation: Tumour Biol. 2014 Nov;35(11):10799-804
references.pmid: 25077923
references.citation: Arch Med Res. 2013 Jul;44(5):380-9
references.pmid: 23871709
references.citation: Gastric Cancer. 2015 Oct;18(4):691-7
references.pmid: 25224659
references.citation: Aktuelle Urol. 2005 Sep;36(5):423-9
references.pmid: 16163605
references.citation: J Gastrointest Surg. 2012 Oct;16(10):1821-9
references.pmid: 22843084
references.citation: BMC Cancer. 2013 Nov 11;13:539
references.pmid: 24206575
references.citation: Science. 1985 Sep 6;229(4717):974-6
references.pmid: 2992089
references.citation: Br J Cancer. 2003 Sep 15;89(6):959-65
references.pmid: 12966408
references.citation: Br J Cancer. 2009 Jul 7;101(1):149-59
references.pmid: 19513073
references.citation: Tumour Biol. 2014 Sep;35(9):8939-43
references.pmid: 24899264
references.citation: Lancet. 2010 Aug 28;376(9742):687-97
references.pmid: 20728210
references.citation: J Clin Pathol. 2008 Jul;61(7):818-24
references.pmid: 18381380
references.citation: Tumour Biol. 2014 Jan;35(1):33-8
references.pmid: 23873100