title: Effect of unilateral mandibular distraction osteogenesis on mandibular morphology in rabbits with antigen-induced temporomandibular joint arthritis.
abstract: Aim was to evaluate effect of unilateral distraction osteogenesis (DO) on mandibular morphology in rabbits with antigen-induced arthritis in the temporomandibular joint (TMJ). Forty 8-week-old rabbits were divided into four groups. In groups A,C, arthritis was induced in the right TMJ. Groups A,B underwent DO. Group D served as control group. Cephalometric analysis of mandibular angle, mandibular ramus height, mandibular collum height, and total posterior mandibular height was done on CT-scans preoperatively (T0), after distraction (T1), and at euthanasia (T2). Two-factor ANOVA evaluated the effect of DO and antigen-induced arthritis. No effect of DO or arthritis was observed on mandibular angle or mandibular collum height. For T0-T1, DO increased mandibular ramus height 12.3% (95% CI 5.2-19.4%) in group B (P=0.001) and total posterior mandibular height 6.2% (95% CI 0.3-12.1%) in group A (P=0.04) and 10.0% (95% CI 4.3-15.7%) in group B (P=0.001). For T1-T2, no significant changes occurred in arthritic rabbits (group A). In conclusion, DO increased total posterior mandibular height in rabbits with arthritis. Postoperatively, no significant effect of DO was observed in rabbits with arthritis. Mandibular DO could be a viable treatment modality in patients with TMJ-arthritis.
authors.affiliation: Section of Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University, Aarhus, Denmark. Electronic address: krisae@rm.dk.
authors.forename: K
authors.initials: K
authors.lastname: Andersen
authors.affiliation: Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark; Section of Orthodontics, Department of Dentistry, Aarhus University, Aarhus, Denmark.
authors.forename: T K
authors.initials: TK
authors.lastname: Pedersen
authors.affiliation: Department of Radiology, Aalborg University Hospital, Aalborg, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Svendsen
authors.affiliation: Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: E M
authors.initials: EM
authors.lastname: Hauge
authors.affiliation: Section of Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University, Aarhus, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Schou
authors.affiliation: Section of Oral and Maxillofacial Surgery and Oral Pathology, Department of Dentistry, Aarhus University, Aarhus, Denmark; Department of Oral and Maxillofacial Surgery, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: S E
authors.initials: SE
authors.lastname: Nørholt
mesh_terms: D000818:Animals; D010003:Osteoarthritis / Q000000981:diagnostic imaging / Q000601:surgery*; D019857:Osteogenesis, Distraction; D011817:Rabbits; D011857:Radiographic Image Interpretation, Computer-Assisted; D011897:Random Allocation; D013705:Temporomandibular Joint Disorders / Q000000981:diagnostic imaging / Q000601:surgery*; D014057:Tomography, X-Ray Computed
keywords: animal experimental study; distraction osteogenesis; juvenile arthritis; rabbits; temporomandibular joint