title: [Comparative analysis of ionizing radiation and xenobiotics influence on spermatogenic epithelium and dominant lethal mutations output in laboratory animals].
abstract: The study covered state of spermatogenic epithelium and dominant lethal mutations output in mice of BALB/c and CBA lines, subjected to total gamma-irradiation and in Wistar rats after intraperitoneal injection of potassium bichromate (K2Cr2,O7) in small and sublethal doses. The BALB/c line mice under low irradiation dose (0.25 Gy) demonstrated stimulation effect on spermatogenic epithelium, but in the CBA line mice no such effect was seen. Both mice lines under irradiation of 0.25 Gy and 1.0 Gy demonstrated increase in pathologic sperm counts and in percentage ofpreimplantation embryonal death. In rats, injection of potassium bichromate in doses of 0.028 mg/kg and 2.8 mg/kg increased number of micronuclear spermatids, larger pathologic sperm counts and percentage of postimplantation deaths. Thus, lower general embryonal deaths under radiation exposure is due to preimplantation embryonal deaths, under exposure to 6-valent chromium--is due to postimplantation losses.
authors.forename: V P
authors.initials: VP
authors.lastname: Mamina
authors.forename: O A
authors.initials: OA
authors.lastname: Zhigal'skiĭ
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D020964:Embryo Loss / Q000139:chemically induced / Q000209:etiology / Q000235:genetics; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D005799:Genes, Dominant / Q000187:drug effects / Q000528:radiation effects; D005804:Genes, Lethal / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009154:Mutation; D011192:Potassium Dichromate / Q000633:toxicity*; D011247:Pregnancy; D017208:Rats, Wistar; D012670:Seminiferous Epithelium / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013087:Spermatids / Q000187:drug effects / Q000528:radiation effects; D013091:Spermatogenesis / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D015262:Xenobiotics; D011192:Potassium Dichromate