title: [Genetically modified animals as model systems of psoriasis].
abstract: Psoriasis is a chronic autoimmune skin disorder. Experimental models of psoriasis can be used to study the disease in controlled conditions. Moreover, the experimental models allow to study a certain aspect of the pathological process. Although none of the multiple mouse models reproduces the human disease precisely, lab animals as model systems can be very helpful because of two reasons. First, introduction of new mutations into animal genome allows to reveal the new genes that may play a certain role in pathogenesis of the disease. Second, the experiments that are carried on the lab animals can be used for testing the new drugs and selection of the most efficient chemical agents from a variety of the proposed experimental preparations. The aim of this paper was to summarize the data on the lab animals that serve as experimental models of psoriasis.
authors.forename: A G
authors.initials: AG
authors.lastname: Soboleva
authors.forename: A V
authors.initials: AV
authors.lastname: Mezentsev
authors.forename: S A
authors.initials: SA
authors.lastname: Bruskin
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001324:Autoantigens / Q000235:genetics; D004195:Disease Models, Animal; D005814:Genes, Viral; D006801:Humans; D008322:Mammals / Q000235:genetics; D008817:Mice, Mutant Strains; D009154:Mutation; D011506:Proteins / Q000235:genetics; D011565:Psoriasis / Q000209:etiology* / Q000235:genetics; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism; D016038:Skin Transplantation
chemical_list: D001324:Autoantigens; D011506:Proteins; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; C110455:Sox13 protein, mouse; C505359:TTC7 protein, mouse