title: State-of-the-Art: Hypo-responsiveness to oral antiplatelet therapy in patients with type 2 diabetes mellitus.
abstract: Diabetes mellitus is a global pandemic, associated with a high burden of cardiovascular disease. There are multiple platelet derangements in patients with diabetes, and antiplatelet drugs remain the first-line agents for secondary prevention as well as for high-risk primary prevention among patients with diabetes. This review provides a summary of oral antiplatelet drug hypo-responsiveness in patients with diabetes, specifically aspirin and Clopidogrel resistance. Topics discussed include antiplatelet testing, definitions used to define hypo-response and resistance, its prevalence, association with clinical outcomes and strategies to mitigate resistance. The role of prasugrel and ticagrelor, as well as investigational agents, is also discussed.
authors.affiliation: UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9047, /
authors.forename: Dharam J
authors.initials: DJ
authors.lastname: Kumbhani
authors.affiliation: UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-, /
authors.forename: Steven P
authors.initials: SP
authors.lastname: Marso
authors.affiliation: Texas Tech University Health Sciences Center, 5920 Forest Park Road, Dallas, TX 75235, /
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Alvarez
authors.affiliation: UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8830, /
authors.forename: Darren K
authors.initials: DK
authors.lastname: McGuire
keywords: Clopidogrel resistance; antiplatelet; antiplatelet resistance; aspirin resistance; diabetes mellitus; high on-treatment platelet reactivity; platelets
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