title: Addition of N-terminal pro-B-type natriuretic peptide levels to electrocardiography criteria for detection of left ventricular hypertrophy: the ARIRANG study.
abstract: The utility of electrocardiography (ECG) in screening for left ventricular hypertrophy (LVH) in general populations is limited mainly because its low sensitivity. B-type natriuretic peptide (BNP) is released due to the remodeling processes of LVH and could improve the diagnostic accuracy for the ECG criteria for LVH. We hypothesized that addition of BNP levels to ECG criteria could aid LVH detection compared with ECG alone in a general population. We enrolled consecutive 343 subjects from a community-based cohort. LVH was defined as LV mass index > 95 g/m(2) for females and > 115 g/m(2) for males according to echocardiography. The area under the receiver operator characteristic (ROC) curve to detect LVH was 0.55 (95% confidence interval [CI], 0.50-0.61) in Sokolow-Lyon criteria and 0.53 (0.47-0.59) in the Cornell voltage criteria. After addition of N-terminal-proBNP levels to the model, the corresponding areas under the ROC were 0.63 (0.58-0.69) and 0.64 (0.59-0.69), respectively. P values for the comparison in areas under the ROC for models with and without N-terminal-proBNP levels were < 0.001. These data suggest that addition of N-terminal-proBNP levels to ECG criteria could significantly improve the diagnostic accuracy of LVH in general populations.
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Min-Soo
authors.identifier: 0000-0001-5730-8215
authors.initials: MS
authors.lastname: Ahn
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Byung-Su
authors.identifier: 0000-0002-3395-4279
authors.initials: BS
authors.lastname: Yoo
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Ji Hyun
authors.identifier: 0000-0002-7162-1248
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Jun-Won
authors.identifier: 0000-0001-6206-1704
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Young Jin
authors.identifier: 0000-0001-7066-7474
authors.initials: YJ
authors.lastname: Youn
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Sung Gyun
authors.identifier: 0000-0002-1528-2739
authors.initials: SG
authors.lastname: Ahn
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Jang-Young
authors.identifier: 0000-0002-0813-7082
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Seung-Hwan
authors.identifier: 0000-0002-1186-0917
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Junghan
authors.identifier: 0000-0002-3363-2675
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Preventive Medicine, Institute of Genomic Cohort, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Jong-Ku
authors.identifier: 0000-0002-6773-1815
authors.initials: JK
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Institute of Genomic Cohort, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Song Vogue
authors.identifier: 0000-0002-2771-6792
authors.initials: SV
authors.lastname: Ahn
authors.affiliation: Institute of Life Style Medicine, Wonju College of Medicine, Yonsei University, Wonju, Korea.
authors.forename: Eunhee
authors.identifier: 0000-0002-3449-0672
authors.initials: E
authors.lastname: Choi
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004562:Electrocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012372:ROC Curve
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Electrocardiography; Hypertrophy; Left Ventricular; Natriuretic Peptides
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