title: The epidemiology and progression time from transient to permanent psychiatric disorders of substance-induced psychosis in Taiwan.
abstract: BACKGROUND
  Substance-induced psychosis (SIP), including alcohol-induced psychotic disorder (AIPD) and substance-induced psychotic disorder (SIPD), is gradually increasing in importance in clinical practice. However, few studies have investigated the epidemiology and progression time from transient to permanent psychiatric disorders for AIPD and SIPD patients.
  
  
  METHODS
  We utilized the National Health Insurance Research Database (NHIRD) to investigate the incidence and prevalence of AIPD and SIPD in Taiwan and determined the timing of AIPD or SIPD followed by the development of persistent psychotic conditions.
  
  
  RESULTS
  The average incidence and prevalence were 1.97 and 2.94 per 100,000 person-years for AIPD, 3.09 and 5.67 per 100,000 person-years for SIPD in Taiwan. Moreover, 10.9% to 24.3% of subjects with either AIPD or SIPD had a change in diagnosis to either schizophrenia or affective disorder, and ~50% of patients had a psychotic or affective transformation in their first year after AIPD and SIPD diagnoses. The mean progression time of psychotic or affective transformation was 1.9 to 2.7 years.
  
  
  CONCLUSIONS
  SIP is a predictive factor for persistent psychotic and affective transformation, and a three-year follow-up may be an optimal clinical practice to prevent psychotic or affective transformation in 60% of patients.
authors.affiliation: Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; Aging Medicine Program, China Medical University, Taichung, Taiwan, ROC. Electronic address: weiling325@vghtc.gov.tw.
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Chen
authors.affiliation: Aging Medicine Program, China Medical University, Taichung, Taiwan, ROC; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC; Department of Biomedical Informatics, Asia University, Taichung, Taiwan, ROC. Electronic address: chhsiehcmu@mail.cmu.edu.tw.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Hsieh
authors.affiliation: Aging Medicine Program, China Medical University, Taichung, Taiwan, ROC; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, ROC; Department of Computer Science and Information Engineering, Asia University, Taichung, Taiwan, ROC. Electronic address: htchang@mail.cmu.edu.tw.
authors.forename: Hao-Teng
authors.initials: HT
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. Electronic address: cocohung@vghtc.gov.tw.
authors.forename: Chia-Chun
authors.initials: CC
authors.lastname: Hung
authors.affiliation: Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. Electronic address: alwin@vghtc.gov.tw.
authors.forename: Chin-Hong
authors.initials: CH
authors.lastname: Chan
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D011605:Psychoses, Substance-Induced / Q000453:epidemiology*; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology
keywords: Alcohol-induced psychotic disorder; National Health Insurance Research Database (NHIRD); Substance-induced psychosis; Substance-induced psychotic disorder