title: Prognostic value of c-Met in colorectal cancer: a meta-analysis.
abstract: OBJECTIVE
  To assess the prognostic value of c-Met status in colorectal cancer.
  
  
  METHODS
  We conducted a search in PubMed, Web of Science, and the Cochrane Library covering all published papers up to July 2014. Only studies assessing survival in colorectal cancer by c-Met status were included. This meta-analysis was performed by using STATA11.0.
  
  
  RESULTS
  Ultimately, 11 studies were included in this analysis. Meta-analysis of the hazard ratios (HR) indicated that patients with high c-Met expression have a significantly poorer overall survival (OR) (HR = 1.33, 95%CI: 1.06-1.59) and progression-free survival (PFS) (HR = 1.47, 95%CI: 1.03-1.91). Subgroup analysis showed a significant association between high c-Met expression and poorer overall survival in the hazard ratio reported (HR = 1.41, 95%CI: 1.08-1.74).
  
  
  CONCLUSIONS
  The present meta-analysis indicated that high c-Met expression was associated with poor prognosis in patients with colorectal cancer.
authors.affiliation: Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Yu
authors.affiliation: Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zou
authors.affiliation: Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Zi-Hua
authors.initials: ZH
authors.lastname: Luo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018572:Disease-Free Survival; D006801:Humans; D016017:Odds Ratio; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D012307:Risk Factors; D015398:Signal Transduction; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: Colorectal cancer; Meta-analysis; Overall survival; Prognosis; c-Met
references.citation: Cancer Chemother Pharmacol. 2014 Apr;73(4):749-57
references.pmid: 24500024
references.citation: Mod Pathol. 2013 Feb;26(2):302-13
references.pmid: 22936063
references.citation: Histopathology. 1999 Oct;35(4):360-7
references.pmid: 10564391
references.citation: Neoplasia. 2000 May-Jun;2(3):226-34
references.pmid: 10935508
references.citation: Ann Surg Oncol. 2002 Dec;9(10):944-53
references.pmid: 12464585
references.citation: Clin Cancer Res. 2003 Nov 1;9(14):5161-70
references.pmid: 14613995
references.citation: Clin Cancer Res. 2004 May 1;10(9):3069-75
references.pmid: 15131045
references.citation: Cancer Cell. 2004 Jul;6(1):75-84
references.pmid: 15261143
references.citation: Cancer. 1990 Nov 1;66(9):1960-6
references.pmid: 2224793
references.citation: Dis Colon Rectum. 1991 Dec;34(12):1097-102
references.pmid: 1959459
references.citation: Jpn J Clin Oncol. 1997 Dec;27(6):378-83
references.pmid: 9437998
references.citation: Stat Med. 1998 Dec 30;17(24):2815-34
references.pmid: 9921604
references.citation: Oncology. 1999;56(4):314-21
references.pmid: 10343196
references.citation: Clin Exp Metastasis. 2004;21(5):409-17
references.pmid: 15672865
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2316-21
references.pmid: 16461907
references.citation: FASEB J. 2006 Aug;20(10):1611-21
references.pmid: 16873884
references.citation: Cancer Lett. 2007 Apr 18;248(2):219-28
references.pmid: 16945480
references.citation: Cancer Lett. 2008 Jul 8;265(2):258-69
references.pmid: 18395971
references.citation: Clin Cancer Res. 2008 Jun 15;14(12):3814-22
references.pmid: 18559601
references.citation: Dis Colon Rectum. 2008 Aug;51(8):1268-74
references.pmid: 18536971
references.citation: Anticancer Res. 2009 Nov;29(11):4807-11
references.pmid: 20032439
references.citation: Clin Colorectal Cancer. 2011 Dec;10(4):325-32
references.pmid: 21729677
references.citation: Int J Colorectal Dis. 2013 Jan;28(1):9-18
references.pmid: 22733437
references.citation: Cancer Sci. 2014 Aug;105(8):1002-7
references.pmid: 24863535