title: Salivary fluoride levels after use of high-fluoride dentifrice.
abstract: The aim of the study was to evaluate salivary fluoride (F) availability after toothbrushing with a high-F dentifrice. Twelve adult volunteers took part in this crossover and blind study. F concentration in saliva was determined after brushing with a high-F dentifrice (5000 µg F/g) or with a conventional F concentration dentifrice (1100 µg F/g) followed by a 15 mL distilled water rinse. Samples of nonstimulated saliva were collected on the following times: before (baseline), and immediately after spit (time = 0) and after 1, 2, 3, 4, 5, 10, 15, 20, 30, 45, 60, 90, and 120 min. F analysis was performed with a fluoride-sensitive electrode and the area under curve of F salivary concentration × time (µg F/mL × min(-1)) was calculated. At baseline, no significant difference was found among dentifrices (P > 0.05). After brushing, both dentifrices caused an elevated fluoride level in saliva; however salivary F concentration was significantly higher at all times, when high-F dentifrice was used (P < 0.01). Even after 120 min, salivary F concentration was still higher than the baseline values for both dentifrices (P < 0.001). High-F dentifrice enhanced the bioavailability of salivary F, being an option for caries management in patients with high caries risk.
authors.affiliation: Federal University of Piauí, 6404-550 Teresina, PI, Brazil.
authors.forename: Glauber Campos
authors.initials: GC
authors.lastname: Vale
authors.affiliation: Federal University of Piauí, 6404-550 Teresina, PI, Brazil.
authors.forename: Priscila Figueiredo
authors.initials: PF
authors.lastname: Cruz
authors.affiliation: Federal University of Piauí, 6404-550 Teresina, PI, Brazil.
authors.forename: Ana Clarissa Cavalcante Elvas
authors.initials: AC
authors.lastname: Bohn
authors.affiliation: Federal University of Piauí, 6404-550 Teresina, PI, Brazil.
authors.forename: Marcoeli Silva
authors.initials: MS
authors.lastname: de Moura
mesh_terms: D000328:Adult; D001682:Biological Availability; D002327:Cariostatic Agents / Q000032:analysis / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D003731:Dental Caries / Q000517:prevention & control; D003802:Dentifrices / Q000737:chemistry*; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012969:Sodium Fluoride / Q000032:analysis; D014099:Toothbrushing; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D012969:Sodium Fluoride; D005459:Fluorides
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