title: Fluoride content in breast milk after the use of fluoridated food supplement. A randomized clinical trial.
abstract: OBJECTIVE
  To evaluate if the intake of a fluoridated food supplement in breastfeeding mothers increases the fluoride concentration in breast milk.
  
  
  METHODS
  A double-blind randomized placebo-controlled study was designed. Two groups of women were formed: a fluoride group (n = 112), using a non-sucrose food supplement containing fluoride (1,500 μg/l for each dose) and a control group (n = 116), using a non-sucrose food supplement without fluoride content. The women were followed for 6 weeks. Samples of breast milk were collected and analyzed using an ion-specific electrode.
  
  
  RESULTS
  85 women in the fluoride group and 83 in the control group concluded the trial. Fluoride concentrations in the two groups were statistically significantly different (515 μg/l in the fluoride and 476 μg/l in the control group P= 0.04) at the end of the experimental period. In the fluoride group, a statistically significant increment in fluoride concentration during the experimental period was also observed (from 468 ± 104 μg/l to 515 ± 105 μg/l). The use of a non-sucrose food supplement containing fluoride resulted in a significant increment in fluoride concentration in breast milk.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Campus
authors.forename: Giovanna
authors.initials: G
authors.lastname: Congiu
authors.forename: Fabio
authors.initials: F
authors.lastname: Cocco
authors.forename: Silvana
authors.initials: S
authors.lastname: Sale
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Cagetti
authors.forename: Gavino
authors.initials: G
authors.lastname: Sanna
authors.forename: Peter
authors.initials: P
authors.lastname: Lingström
authors.forename: Franklin
authors.initials: F
authors.lastname: Garcia-Godoy
mesh_terms: D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis*; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D010919:Placebos
chemical_list: D010919:Placebos; D005459:Fluorides