title: Four new tetramic acid and one new furanone derivatives from the plant endophytic fungus Neopestalotiopsis sp.
abstract: Four new tetramic acid analogues neopestalotins A-D (1-4), one new furanone derivative neopestalotin E (6), and the known compound hymenosetin have been isolated from the solid cultures of the plant endophytic fungus Neopestalotiopsis sp. The structures of the new compounds were determined mainly by nuclear magnetic resonance (NMR) experiments. The absolute configurations of 1 and 2 were assigned by circular dichroism (CD) data, whereas those of 3 and 4 were deduced by a combination of CD and heteronuclear long range coupling (HETLOC) data. Compound 2 showed modest antimicrobial activity against the Gram-positive bacteria, Bacillus subtilis, Staphylococcus aureus col, and Streptococcus pneumoniae.
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Zhao
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Shenxi
authors.initials: S
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, AMMS, Beijing 100850, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Shubin
authors.initials: S
authors.lastname: Niu
authors.affiliation: Novozymes (China) Investment Co. Ltd China Headquarters, 14 Xinli Road, Shangdi Zone, Haidian District, Beijing 100085, PR China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, AMMS, Beijing 100850, PR China. Electronic address: cheys@im.ac.cn.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000085:Acetates / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001412:Bacillus subtilis / Q000187:drug effects; D060026:Endophytes / Q000737:chemistry; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D005663:Furans; D011760:Pyrrolidinones; C009435:tetramic acid
keywords: Antibacterial activity; Equisetin (PubChem CID: 54684703); Furanone; Neopestalotiopsis sp.; Structure elucidation; Tetramic acid