title: The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.
abstract: Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regarding the association between catalase C-262T polymorphism and cancer risk were identified, and data were retrieved and analyzed by using Review Manager 5.0.24 and STATA 12.0. A total of 18 publications with 22 case-control studies, including 9777 cancer patients and 12,223 controls, met the inclusion criteria. Meta-analysis results showed significant association between catalase C-262 T polymorphism and cancer risk (TT vs CT + CC: odds ratio [OR] = 1.17, 95% confidence interval [CI] = 1.03-1.31, P = 0.01). Subgroup analyses stratified by cancer types suggested the catalase C-262T polymorphism was significantly associated with an increased prostate cancer risk (TT vs CT + CC: OR = 1.61, 95% CI = 1.17-2.22, P = 0.004); for subgroup analyses stratified by ethnicity, no associations between this polymorphism and Asians or whites were identified (CT + TT vs CC: OR = 1.11, 95% CI = 0.98-1.26, P = 0.09 for whites; OR = 1.19, 95% CI = 0.78-1.80, P = 0.42 for Asians). In summary, the catalase C-262T polymorphism may be a risk factor for cancer with cancer type-specific effects. Further studies should be performed to confirm these findings.
authors.affiliation: From the Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China (YS, DL, PT, JZ, MF, CW, TY, LC); and Radiation Physics Center, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, China (KS).
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.forename: Diandian
authors.initials: D
authors.lastname: Li
authors.forename: Panwen
authors.initials: P
authors.lastname: Tian
authors.forename: Konglong
authors.initials: K
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Mei
authors.initials: M
authors.lastname: Feng
authors.forename: Chun
authors.initials: C
authors.lastname: Wan
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wen
mesh_terms: D002374:Catalase; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044469:Racial Groups; D012307:Risk Factors
chemical_list: C577219:CAT protein, human; D002374:Catalase
references.citation: Cytokine. 2011 Aug;55(2):266-73
references.pmid: 21570316
references.citation: J Nutr. 2011 Sep;141(9):1731-7
references.pmid: 21795425
references.citation: Biochem Pharmacol. 2011 Nov 15;82(10):1384-90
references.pmid: 21689642
references.citation: Biomed Pharmacother. 2011 Oct;65(7):516-24
references.pmid: 21993000
references.citation: Ann Clin Biochem. 2012 Mar;49(Pt 2):152-8
references.pmid: 22130631
references.citation: Infect Genet Evol. 2012 Aug;12(6):1189-94
references.pmid: 22522002
references.citation: Anticancer Res. 2012 Jul;32(7):2599-624
references.pmid: 22753718
references.citation: Clin Genitourin Cancer. 2012 Dec;10(4):251-5
references.pmid: 22959522
references.citation: J Nutrigenet Nutrigenomics. 2012;5(6):339-51
references.pmid: 23363810
references.citation: J Gastroenterol Hepatol. 2013 May;28(5):819-22
references.pmid: 23425094
references.citation: BJU Int. 2013 Aug;112(4):E406-14
references.pmid: 23773345
references.citation: Annu Rev Genomics Hum Genet. 2013;14:441-65
references.pmid: 23724904
references.citation: Nat Rev Drug Discov. 2013 Dec;12(12):931-47
references.pmid: 24287781
references.citation: Exp Cell Res. 2014 Apr 15;323(1):28-40
references.pmid: 24583396
references.citation: Semin Cancer Biol. 2014 Apr;25:23-32
references.pmid: 24406211
references.citation: CA Cancer J Clin. 2014 Jul-Aug;64(4):252-71
references.pmid: 24890451
references.citation: Biomed Pharmacother. 2014 Jun;68(5):603-9
references.pmid: 24855033
references.citation: Medicine (Baltimore). 2015 Jan;94(1):e283
references.pmid: 25569644
references.citation: Tumour Biol. 2015 Feb;36(2):909-14
references.pmid: 25307973
references.citation: Pathol Oncol Res. 2015 Apr;21(2):433-7
references.pmid: 25248722
references.citation: Cancer. 2000 Jul 1;89(1):123-34
references.pmid: 10897009
references.citation: Cancer Res. 2005 Feb 1;65(3):948-56
references.pmid: 15705895
references.citation: Am J Epidemiol. 2005 Nov 15;162(10):943-52
references.pmid: 16192345
references.citation: Lancet. 2005 Nov 19;366(9499):1784-93
references.pmid: 16298215
references.citation: Cancer Res. 2006 Jan 15;66(2):1225-33
references.pmid: 16424062
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1217-22
references.pmid: 16775184
references.citation: Haematologica. 2006 Sep;91(9):1222-7
references.pmid: 16956821
references.citation: Stat Med. 2006 Oct 30;25(20):3443-57
references.pmid: 16345038
references.citation: J Thorac Oncol. 2006 Sep;1(7):648-53
references.pmid: 17409931
references.citation: J Obstet Gynaecol Res. 2007 Apr;33(2):155-60
references.pmid: 17441888
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1115-20
references.pmid: 17548672
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1082-7
references.pmid: 18483329
references.citation: Cancer Lett. 2008 Jul 18;266(1):53-9
references.pmid: 18362051
references.citation: Neuro Oncol. 2008 Oct;10(5):709-15
references.pmid: 18682580
references.citation: Carcinogenesis. 2009 May;30(5):777-84
references.pmid: 19255063
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2336-8
references.pmid: 19622717
references.citation: Antioxid Redox Signal. 2009 Dec;11(12):2985-3011
references.pmid: 19505186
references.citation: Free Radic Res. 2010 Feb;44(2):208-16
references.pmid: 19929244
references.citation: Carcinogenesis. 2010 Apr;31(4):607-13
references.pmid: 20097730
references.citation: J Dermatol Sci. 2010 Oct;60(1):54-6
references.pmid: 20727719