title: Shaping of biological tubes by mechanical interaction of cell and extracellular matrix.
abstract: The shape of biological tubes is optimized for supporting efficient circulation of liquid and gas and to maintain organismal homeostasis. Maintaining a constant tube diameter and fitting tube length to body size are two requirements for proper tube function. The tracheal system of the Drosophila embryo is established through branching of ectodermal epithelia in the absence of environmental air, and the branching pattern and geometry of this system are genetically specified. Recent studies identified apical extracellular matrix (aECM) as a crucial regulator of tube expansion and elongation. Evidence suggests that aECM coordinates apical membrane growth and cell contractility to control tube growth at the tissue level. In the present review, we will discuss the physical mechanisms underlying this interaction.
authors.affiliation: Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China; Institute of Evolution & Marine Biodiversity, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
authors.affiliation: Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan; Department of Biology, Kobe University Graduate School of Science, 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8051, Japan. Electronic address: shayashi@cdb.riken.jp.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D002686:Chitin / Q000378:metabolism; D004330:Drosophila / Q000196:embryology*; D004475:Ectoderm / Q000196:embryology*; D005109:Extracellular Matrix / Q000502:physiology; D049452:Green Fluorescent Proteins / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics / Q000502:physiology*; D020545:Respiratory Mucosa / Q000502:physiology*; D012137:Respiratory System / Q000196:embryology*
chemical_list: D002686:Chitin; D049452:Green Fluorescent Proteins