title: Difference in the prognostic significance of N-terminal pro-B-type natriuretic peptide between cardioembolic and noncardioembolic ischemic strokes.
abstract: OBJECTIVE
  Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) between cardioembolic and noncardioembolic stroke subgroups.
  
  
  METHODS
  410 acute stroke patients were included. According to the presence of a cardioembolic source (CES), there were 221 patients with CES and 189 patients without CES. Logistic regression analysis was performed to ascertain the association between NT-proBNP and 6-month mortality/functional outcome in each group.
  
  
  RESULTS
  The mean age of our patients was 67.2 years (range, 18-97 years). NT-proBNP was a multivariate independent predictor of mortality in the CES group alone, whereas it was only a univariate predictor of 6-month mortality in the total patient and non-CES groups with its association disappearing in the multivariate model. In addition, it was only a univariate predictor of good functional outcome in all of the groups.
  
  
  CONCLUSIONS
  Our data suggest that NT-proBNP can more reliably predict 6-month mortality in patients with cardioembolic stroke than in patients with other stroke subtypes.
authors.affiliation: Department of Neurology, Sejong General Hospital, Bucheon 422-711, Republic of Korea.
authors.forename: Seung-Jae
authors.identifier: 0000-0003-2299-4870
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Neurology, Sejong General Hospital, Bucheon 422-711, Republic of Korea.
authors.forename: Dong-Geun
authors.initials: DG
authors.lastname: Lee
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon 422-711, Republic of Korea.
authors.forename: Dal-Soo
authors.initials: DS
authors.lastname: Lim
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon 422-711, Republic of Korea.
authors.forename: Sukkeun
authors.identifier: 0000-0001-9054-9459
authors.initials: S
authors.lastname: Hong
authors.affiliation: Department of Cardiology, Sejong General Hospital, Bucheon 422-711, Republic of Korea.
authors.forename: Jin-Sik
authors.initials: JS
authors.lastname: Park
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D020521:Stroke / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
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