title: Soluble c-Met is a reliable and sensitive marker to detect c-Met expression level in lung cancer.
abstract: c-Met has been demonstrated as an attractive target in lung cancer therapy. Current studies showed that detection of c-Met status in tumor is critical in Met-targeted therapy. However not all patients are suitable for tissue sample collection. It is important to discover novel surrogate markers to detect c-Met status. In the study, soluble c-Met (s-Met) in plasma from 146 Chinese lung cancer patients and 40 disease-free volunteers was measured by enzyme-linked immunosorbent. In parallel, expression of c-Met in those tumors was also assessed by immunohistochemistry. Results showed that, in 146 lung cancer patients, 93 were c-Met expression positive and 74 of 93 were overexpressed. In c-Met-overexpressed patients, plasma s-Met was significantly increased. And further studies showed that plasma s-Met linearly correlated with c-Met expression in tumor. After tumor was removed in Met-overexpressed patients via resection, plasma s-Met significantly decreased to basal level. In addition, plasma s-Met showed to be poorly correlated with tumor size in Met-overexpressed patients. These results demonstrated that plasma s-Met is a sensitive and reliable marker to detect c-Met overexpression in lung cancers, and it is independent of tumor volume.
authors.affiliation: Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Huilai
authors.initials: H
authors.lastname: Lv
authors.affiliation: Tumor Research Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Baoen
authors.initials: B
authors.lastname: Shan
authors.affiliation: Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Tian
authors.affiliation: Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Yuefeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Fifth Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Shiwang
authors.initials: S
authors.lastname: Wen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis* / Q000235:genetics; D047368:Tumor Burden / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D019859:Proto-Oncogene Proteins c-met
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