title: Does Dopamine Replacement Medication Affect Postural Sequence Learning in Parkinson's Disease?
abstract: Deficits in sequence-specific learning (SSL) may be a product of Parkinson's disease (PD) but this deficit could also be related to dopamine replacement. The purpose of this study was to determine whether dopamine replacement affected acquisition and retention of a standing Continuous Tracking Task in individuals with PD. SSL (difference between random/repeated Root Mean Square Error across trials) was calculated over 2 days of practice and 1 day of retention for 4 groups; 10 healthy young (HY), 10 healthy elders, 10 individuals with PD on, 9 individuals with PD off their usual dosage of dopamine replacement. Improvements in acquisition were observed for all groups; however, only the HY demonstrated retention. Therefore, age appeared to have the largest effect on SSL with no significant effect of medication. Additional research is needed to understand the influence of factors such as practice amount, task difficulty, and dopamine replacement status on SSL deficits during postural tasks.
authors.affiliation: Dept. of Physical Therapy, University of Utah, Salt Lake City, UT.
authors.forename: Heather Anne
authors.initials: HA
authors.lastname: Hayes
authors.forename: Nikelle
authors.initials: N
authors.lastname: Hunsaker
authors.forename: Sydney Y
authors.initials: SY
authors.lastname: Schaefer
authors.forename: Barry
authors.initials: B
authors.lastname: Shultz
authors.forename: Thomas
authors.initials: T
authors.lastname: Schenkenberg
authors.forename: Lara A
authors.initials: LA
authors.lastname: Boyd
authors.forename: Andrea T
authors.initials: AT
authors.lastname: White
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Foreman
authors.forename: Philip
authors.initials: P
authors.lastname: Dyer
authors.forename: Rebecca
authors.initials: R
authors.lastname: Maletsky
authors.forename: Leland E
authors.initials: LE
authors.lastname: Dibble
mesh_terms: D000328:Adult; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D011187:Posture
chemical_list: D004298:Dopamine