title: Lipodystrophies: adipose tissue disorders with severe metabolic implications.
abstract: Lipodystrophy encompass a group of heterogeneous disorders consisting in marked reduction, absence, and/or the redistribution of adipose tissue. Lipodystrophy is frequently complicated with severe insulin resistance, diabetes, hyperlipidemia, and fatty liver. Anatomically, lipodystrophies can be partial or generalized. Etiologically, they can be congenital or acquired. Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. Conventional insulin-sensitizing approaches usually fail to fully ameliorate insulin resistance in lipodystrophic patients. Leptin replacement is an approved therapy for the metabolic complications of congenital generalized lipodystrophy. Novel nutritional interventions are promising complementary approaches for treating lipodystrophy metabolic complications.
authors.affiliation: Department of Nutrition, Diabetes and Metabolism, Pontificia Universidad Católica de Chile, C/ Av. Libertador Bernardo O'Higgins 340, Santiago, Chile, vcortes@med.puc.cl.
authors.forename: Víctor A
authors.initials: VA
authors.lastname: Cortés
authors.forename: Marta
authors.initials: M
authors.lastname: Fernández-Galilea
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D006801:Humans; D007333:Insulin Resistance; D008060:Lipodystrophy / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*
references.citation: Hum Mol Genet. 2000 Jan 1;9(1):109-12
references.pmid: 10587585
references.citation: Am J Med Genet A. 2010 Sep;152A(9):2245-53
references.pmid: 20684003
references.citation: Diabetes Care. 2013 Aug;36(8):2247-53
references.pmid: 23423695
references.citation: Circulation. 2012 Jun 5;125(22):2782-91
references.pmid: 22665886
references.citation: Tex Heart Inst J. 2008;35(2):196-9
references.pmid: 18612489
references.citation: J Clin Endocrinol Metab. 2004 Sep;89(9):4258-63
references.pmid: 15356018
references.citation: J Pediatr Endocrinol Metab. 2002 Apr;15(4):441-7
references.pmid: 12008692
references.citation: Rev Med Chil. 2014 Jun;142(6):738-47
references.pmid: 25327319
references.citation: Eur J Epidemiol. 2009;24(5):267-74
references.pmid: 19322667
references.citation: Metabolism. 1997 Feb;46(2):159-63
references.pmid: 9030822
references.citation: Medicine (Baltimore). 2004 Jan;83(1):18-34
references.pmid: 14747765
references.citation: J Cell Biol. 2009 Dec 28;187(7):945-57
references.pmid: 20038676
references.citation: Clin J Am Soc Nephrol. 2006 Jul;1(4):616-22
references.pmid: 17699267
references.citation: Diabetes Care. 2013 Aug;36(8):2142-5
references.pmid: 23881965
references.citation: PLoS One. 2014 Feb 26;9(2):e89088
references.pmid: 24586518
references.citation: Ann Nutr Metab. 2010;57(1):9-17
references.pmid: 20616542
references.citation: Clin Genet. 2010 Jul;78(1):66-73
references.pmid: 20041886
references.citation: Medicine (Baltimore). 2003 Mar;82(2):129-46
references.pmid: 12640189
references.citation: J Clin Endocrinol Metab. 1954 Feb;14(2):193-204
references.pmid: 13130666
references.citation: J Clin Endocrinol Metab. 2004 Jul;89(7):3199-207
references.pmid: 15240593
references.citation: Am J Physiol Endocrinol Metab. 2004 Feb;286(2):E252-60
references.pmid: 14570702
references.citation: Semin Immunopathol. 2015 Jan;37(1):39-46
references.pmid: 25315349
references.citation: Diabetes Care. 2003 Jan;26(1):30-5
references.pmid: 12502655
references.citation: Q J Med. 1974 Jan;43(169):33-48
references.pmid: 4362786
references.citation: J Clin Endocrinol Metab. 2002 Jan;87(1):408-11
references.pmid: 11788685
references.citation: Nature. 1999 Sep 2;401(6748):73-6
references.pmid: 10485707
references.citation: Nature. 2002 Jan 17;415(6869):339-43
references.pmid: 11797013
references.citation: Hum Mol Genet. 2011 Oct 1;20(19):3779-86
references.pmid: 21724554
references.citation: J Biol Chem. 2012 Nov 23;287(48):40441-7
references.pmid: 23024365
references.citation: Diabetes Care. 2003 Jun;26(6):1819-24
references.pmid: 12766116
references.citation: Humangenetik. 1975 Sep 10;29(2):111-20
references.pmid: 170190
references.citation: Diabetologia. 2011 Jul;54(7):1639-44
references.pmid: 21479595
references.citation: Cell. 2007 Jan 26;128(2):309-23
references.pmid: 17254969
references.citation: Jpn J Med. 1989 Jul-Aug;28(4):534-7
references.pmid: 2530377
references.citation: Nutr Metab Cardiovasc Dis. 2014 Mar;24(3):216-9
references.pmid: 24462051
references.citation: J Clin Endocrinol Metab. 2007 Feb;92(2):532-41
references.pmid: 17118991
references.citation: PLoS One. 2013 Apr 12;8(4):e61380
references.pmid: 23593476
references.citation: N Engl J Med. 2011 Feb 24;364(8):740-8
references.pmid: 21345103
references.citation: Trends Pharmacol Sci. 2005 Feb;26(2):88-93
references.pmid: 15681026
references.citation: J Clin Endocrinol Metab. 2007 Dec;92(12):4835-44
references.pmid: 17711925
references.citation: Diabetes Obes Metab. 2008 Dec;10(12):1275-6
references.pmid: 19040647
references.citation: Diabetes. 2005 Jul;54(7):1994-2002
references.pmid: 15983199
references.citation: Metabolism. 2009 Jun;58(6):854-9
references.pmid: 19375132
references.citation: J Clin Endocrinol Metab. 2011 Nov;96(11):3313-25
references.pmid: 21865368
references.citation: Obstet Gynecol. 2012 Feb;119(2 Pt 2):452-5
references.pmid: 22270436
references.citation: Am J Transplant. 2004 Mar;4(3):447-9
references.pmid: 14962001
references.citation: N Engl J Med. 2002 Feb 21;346(8):570-8
references.pmid: 11856796
references.citation: Acta Paediatr. 1959 Nov;48:555-74
references.pmid: 14444642
references.citation: Trends Endocrinol Metab. 2010 Jun;21(6):345-52
references.pmid: 20223680
references.citation: J Clin Invest. 2004 Feb;113(3):414-24
references.pmid: 14755338
references.citation: J Am Geriatr Soc. 1977 Apr;25(4):175-8
references.pmid: 845358
references.citation: PLoS One. 2014 Jan 31;9(1):e87173
references.pmid: 24498038
references.citation: J Lipid Res. 2014 Feb;55(2):276-88
references.pmid: 24293639
references.citation: J Clin Invest. 2002 May;109(10):1345-50
references.pmid: 12021250
references.citation: Diabetologia. 2010 Jan;53(1):27-35
references.pmid: 19727665
references.citation: Endocrinol Metab Clin North Am. 2008 Sep;37(3):753-68, x-xi
references.pmid: 18775362