title: Nickel-catalyzed direct thiolation of C(sp(3))-H bonds in aliphatic amides.
abstract: Nickel-catalyzed thiolation of the inactivated methyl C(sp(3))-H bonds of aliphatic amides with disulfide is described. It is a novel strategy for the synthesis of thioethers with the ultimate goal of generating thioether carboxylic acids with various functional groups.
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
authors.forename: Xie
authors.initials: X
authors.lastname: Wang
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.|‡Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, 565-0871, Japan.
authors.forename: Renhua
authors.initials: R
authors.lastname: Qiu
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
authors.forename: Chunyang
authors.initials: C
authors.lastname: Yan
authors.affiliation: ‡Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Osaka, 565-0871, Japan.
authors.forename: Vutukuri Prakash
authors.initials: VP
authors.lastname: Reddy
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
authors.forename: Longzhi
authors.initials: L
authors.lastname: Zhu
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Xu
authors.affiliation: †State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
authors.forename: Shuang-Feng
authors.initials: SF
authors.lastname: Yin
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D013438:Sulfhydryl Compounds; D009532:Nickel