title: Exercise intensity and the protection from postprandial vascular dysfunction in adolescents.
abstract: Acute exercise transiently improves endothelial function and protects the vasculature from the deleterious effects of a high-fat meal (HFM). We sought to identify whether this response is dependent on exercise intensity in adolescents. Twenty adolescents (10 male, 14.3 ± 0.3 yr) completed three 1-day trials: 1) rest (CON); 2) 8 × 1 min cycling at 90% peak power with 75 s recovery [high-intensity interval exercise (HIIE)]; and 3) cycling at 90% of the gas exchange threshold [moderate-intensity exercise (MIE)] 1 h before consuming a HFM (1.50 g/kg fat). Macrovascular and microvascular endothelial function was assessed before and immediately after exercise and 3 h after the HFM by flow-mediated dilation (FMD) and laser Doppler imaging [peak reactive hyperemia (PRH)]. FMD and PRH increased 1 h after HIIE [P < 0.001, effect size (ES) = 1.20 and P = 0.048, ES = 0.56] but were unchanged after MIE. FMD and PRH were attenuated 3 h after the HFM in CON (P < 0.001, ES = 1.78 and P = 0.02, ES = 0.59). FMD remained greater 3 h after the HFM in HIIE compared with MIE (P < 0.001, ES = 1.47) and CON (P < 0.001, ES = 2.54), and in MIE compared with CON (P < 0.001, ES = 1.40). Compared with CON, PRH was greater 3 h after the HFM in HIIE (P = 0.02, ES = 0.71) and MIE (P = 0.02, ES = 0.84), with no differences between HIIE and MIE (P = 0.72, ES = 0.16). Plasma triacylglycerol concentration and total antioxidant status concentration were not different between trials. We conclude that exercise intensity plays an important role in protecting the vasculature from the deleterious effects of a HFM. Performing HIIE may provide superior vascular benefits than MIE in adolescent groups.
authors.affiliation: Children's Health and Exercise Research Centre, Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom;
authors.forename: B
authors.initials: B
authors.lastname: Bond
authors.affiliation: Diabetes and Vascular Medicine, University of Exeter Medical School, Exeter, United Kingdom; and.
authors.forename: P E
authors.initials: PE
authors.lastname: Gates
authors.affiliation: Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom.
authors.forename: S R
authors.initials: SR
authors.lastname: Jackman
authors.affiliation: Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom.
authors.forename: L M
authors.initials: LM
authors.lastname: Corless
authors.affiliation: Children's Health and Exercise Research Centre, Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom;
authors.forename: C A
authors.initials: CA
authors.lastname: Williams
authors.affiliation: Children's Health and Exercise Research Centre, Sport and Health Science, College of Life and Environmental Sciences, University of Exeter, Exeter, United Kingdom; A.R.Barker@exeter.ac.uk.
authors.forename: A R
authors.initials: AR
authors.lastname: Barker
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D059305:Diet, High-Fat / Q000009:adverse effects*; D004730:Endothelium, Vascular / Q000502:physiology*; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D019518:Postprandial Period; D014652:Vascular Diseases / Q000209:etiology / Q000517:prevention & control*; D014664:Vasodilation
keywords: cardiovascular disease; endothelial function; postprandial lipemia; young people