title: Preventive role of estradiol on kidney injury induced by renal ischemia-reperfusion in male and female rats.
abstract: BACKGROUND
  Renal ischemia-reperfusion (RIR) is the main cause of renal failure. The incidence of RIR injury seems to be gender-related due to female sex hormone; estrogen. This study was designed to investigate the protective role of estrogen against RIR injury in male and ovariectomized female rats.
  
  
  METHODS
  Thirty-nine Wistar rats were used in this study as male and ovariectomized female rats in the sham-operated, RIR, and estradiol-treated plus RIR groups. The RIR was induced by clamping the renal vessels for 45 min and then 24 h of reperfusion. All animals finally were sacrificed for the measurements.
  
  
  RESULTS
  The serum levels of creatinine and blood urea nitrogen and kidney tissue damage score significantly increased in both male and female RIR rats (P < 0.05). Estradiol however significantly attenuated theses parameters (P < 0.05) toward normal levels in female (P < 0.05), but not in male rats. Kidney weight increased in both genders and estradiol intensified it in the male rats (P < 0.05). Uterus weight was increased by estradiol in female rats (P < 0.05) and testis weight did not alter in male rats.
  
  
  CONCLUSIONS
  Estradiol demonstrated a protective role against RIR injury in female rats; however, estradiol as an antioxidant could not protect the male kidney from RIR injury.
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Iran-Nejad
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Institute of Basic and Applied Sciences Research, Isfahan, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nematbakhsh
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Eshraghi-Jazi
authors.affiliation: Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
keywords: Estrogen; gender; rat; renal ischemia-reperfusion
references.citation: Am J Physiol Renal Physiol. 2005 Feb;288(2):F399-405
references.pmid: 15454392
references.citation: Kidney Int. 2000 Jun;57(6):2375-85
references.pmid: 10844607
references.citation: PLoS One. 2013 Apr 12;8(4):e60716
references.pmid: 23593292
references.citation: Physiol Res. 2009;58(6):909-12
references.pmid: 19093730
references.citation: Kidney Int. 2002 Oct;62(4):1364-71
references.pmid: 12234307
references.citation: J Am Soc Nephrol. 2000 Feb;11(2):319-29
references.pmid: 10665939
references.citation: J Physiol Biochem. 2007 Sep;63(3):195-201
references.pmid: 18309775
references.citation: Anesthesiology. 2010 Feb;112(2):395-405
references.pmid: 20068453
references.citation: Toxicol Int. 2013 Jan;20(1):43-7
references.pmid: 23833437
references.citation: J Am Soc Nephrol. 2004 Jun;15(6):1546-56
references.pmid: 15153565
references.citation: J Am Soc Nephrol. 2004 Feb;15(2):348-58
references.pmid: 14747381
references.citation: J Cereb Blood Flow Metab. 2004 Oct;24(10):1160-6
references.pmid: 15529016
references.citation: Neurosci Lett. 2005 Jul 15;382(3):286-90
references.pmid: 15885907
references.citation: Biochem Biophys Res Commun. 2005 Mar 4;328(1):312-7
references.pmid: 15670785
references.citation: J Am Coll Cardiol. 1997 Oct;30(4):914-9
references.pmid: 9316518
references.citation: J Physiol Biochem. 2009 Jun;65(2):183-91
references.pmid: 19886397
references.citation: J Steroid Biochem Mol Biol. 1993 Jun;45(6):509-11
references.pmid: 8518206
references.citation: Clin Sci (Lond). 2002 Aug;103 Suppl 48:434S-437S
references.pmid: 12193139
references.citation: Am J Kidney Dis. 1995 Apr;25(4):515-33
references.pmid: 7702046
references.citation: J Am Soc Nephrol. 2002 Nov;13(11):2681-7
references.pmid: 12397037
references.citation: Int J Prev Med. 2013 Jun;4(6):648-55
references.pmid: 23930182
references.citation: Endocr Rev. 1990 Aug;11(3):443-53
references.pmid: 2226350
references.citation: Cell Immunol. 1992 Jun;142(1):67-78
references.pmid: 1586960
references.citation: J Pharmacol Toxicol Methods. 1997 Feb;37(1):1-7
references.pmid: 9086282
references.citation: Kidney Int. 2006 Nov;70(10):1759-68
references.pmid: 17021606
references.citation: J Am Soc Nephrol. 2003 Dec;14(12):3102-10
references.pmid: 14638909
references.citation: Clin Exp Pharmacol Physiol. 1999 Feb;26(2):127-31
references.pmid: 10065333
references.citation: Kidney Int. 1996 Oct;50(4):1173-9
references.pmid: 8887275
references.citation: Int J Nephrol. 2012;2012:284896
references.pmid: 23056943
references.citation: ISRN Oncol. 2012;2012:890310
references.pmid: 23227363
references.citation: Surgery. 2011 Jul;150(1):39-47
references.pmid: 21596414
references.citation: Kidney Int. 2004 Oct;66(4):1613-21
references.pmid: 15458458
references.citation: Bone Miner. 1991 Nov;15(2):109-23
references.pmid: 1764629
references.citation: Int J Prev Med. 2013 Oct;4(10):1139-46
references.pmid: 24319553
references.citation: J Biol Chem. 2004 Dec 10;279(50):52282-92
references.pmid: 15358759
references.citation: Transpl Int. 2002 Oct;15(9-10):494-501
references.pmid: 12389082
references.citation: Biol Reprod. 2000 Oct;63(4):982-5
references.pmid: 10993817
references.citation: Am J Physiol Renal Physiol. 2001 Mar;280(3):F365-88
references.pmid: 11181399
references.citation: Circulation. 1995 Jul 1;92(1):24-30
references.pmid: 7788912
references.citation: Kidney Int. 2008 Feb;73(3):308-17
references.pmid: 18004295