title: [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
abstract: Cytokines CCL11 (eotaxin) and HMGB1 (alarmin1) are molecular markers of ageing and neurological, cardiovascular and immune diseases. Created in St. Petersburg Institute of Bioregulation and Gerontology short peptides are known to regulate gene expression and protein synthesis. They promote the mortality decrease and slowdown the development of pathology in the elderly. The article presents the proposed role of dipeptide vilon (Lys-Glu) and tetrapeptide epitalon (Ala-Glu-Asp-Gly) in CCL11 and HMGB1 genes regulation as activators of their expression. Geroprotective action of vilon and epitalon probably realizes in suppression of these genes.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: S I
authors.initials: SI
authors.lastname: Tarnovskaia
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism / Q000517:prevention & control; D001483:Base Sequence; D001665:Binding Sites; D015415:Biomarkers / Q000378:metabolism; D054413:Chemokine CCL11 / Q000235:genetics / Q000378:metabolism*; D004151:Dipeptides / Q000008:administration & dosage / Q000627:therapeutic use*; D005786:Gene Expression Regulation / Q000187:drug effects; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000517:prevention & control; D009842:Oligopeptides / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; D054413:Chemokine CCL11; D004151:Dipeptides; D024243:HMGB1 Protein; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine