title: Early maternal deprivation enhances voluntary alcohol intake induced by exposure to stressful events later in life.
abstract: In the present study, we aimed to assess the impact of early life stress, in the form of early maternal deprivation (MD, 24 h on postnatal day, pnd, 9), on voluntary alcohol intake in adolescent male and female Wistar rats. During adolescence, from pnd 28 to pnd 50, voluntary ethanol intake (20%, v/v) was investigated using the two-bottle free choice paradigm. To better understand the relationship between stress and alcohol consumption, voluntary alcohol intake was also evaluated following additional stressful events later in life, that is, a week of alcohol cessation and a week of alcohol cessation combined with exposure to restraint stress. Female animals consumed more alcohol than males only after a second episode of alcohol cessation combined with restraint stress. MD did not affect baseline voluntary alcohol intake but increased voluntary alcohol intake after stress exposure, indicating that MD may render animals more vulnerable to the effects of stress on alcohol intake. During adolescence, when animals had free access to alcohol, MD animals showed lower body weight gain but a higher growth rate than control animals. Moreover, the higher growth rate was accompanied by a decrease in food intake, suggesting an altered metabolic regulation in MD animals that may interact with alcohol intake.
authors.affiliation: Departamento de Fisiología (Fisiología Animal II), Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Peñasco
authors.affiliation: Departamento de Fisiología (Fisiología Animal II), Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Mela
authors.affiliation: Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense, 28223 Madrid, Spain.
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: López-Moreno
authors.affiliation: Departamento de Fisiología (Fisiología Animal II), Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: María-Paz
authors.initials: MP
authors.lastname: Viveros
authors.affiliation: Departamento de Fisiología (Fisiología Animal II), Facultad de Ciencias Biológicas, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Marco
mesh_terms: D000818:Animals; D058999:Drug-Seeking Behavior / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D008297:Male; D008426:Maternal Deprivation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012646:Self Administration; D013315:Stress, Psychological
chemical_list: D000431:Ethanol
references.citation: PLoS One. 2012;7(11):e48915
references.pmid: 23145019
references.citation: Neuroscience. 2012 Oct 25;223:296-304
references.pmid: 22890080
references.citation: Neuron. 2013 Jul 10;79(1):16-29
references.pmid: 23849196
references.citation: Toxicology. 2013 Sep 6;311(1-2):78-86
references.pmid: 23246480
references.citation: Pharmacol Res. 2013 Aug;74:23-33
references.pmid: 23680694
references.citation: Psychopharmacology (Berl). 2013 Oct;229(4):555-69
references.pmid: 23982922
references.citation: Eur Neuropsychopharmacol. 2014 Jul;24(7):1152-61
references.pmid: 24745548
references.citation: Psychopharmacology (Berl). 2001 Dec;158(4):366-73
references.pmid: 11797057
references.citation: Biol Psychiatry. 2001 Jun 15;49(12):1023-39
references.pmid: 11430844
references.citation: Mol Cell Biochem. 2014 Aug;393(1-2):43-57
references.pmid: 24671494
references.citation: Mol Psychiatry. 2002;7(6):609-16
references.pmid: 12140784
references.citation: Pharmacol Ther. 2002 Apr-May;94(1-2):137-56
references.pmid: 12191599
references.citation: Alcohol Clin Exp Res. 2003 Jan;27(1):31-7
references.pmid: 12544002
references.citation: Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):73-82
references.pmid: 12732224
references.citation: Ment Retard Dev Disabil Res Rev. 2003;9(3):149-54
references.pmid: 12953293
references.citation: Neuroscience. 2003;121(3):787-99
references.pmid: 14568037
references.citation: Alcohol. 2004 May;33(1):31-9
references.pmid: 15353171
references.citation: Dev Psychobiol. 2004 Nov;45(3):140-52
references.pmid: 15505796
references.citation: Alcohol Clin Exp Res. 2005 Apr;29(4):591-601
references.pmid: 15834224
references.citation: Alcohol Clin Exp Res. 2005 Jul;29(7):1139-45
references.pmid: 16046868
references.citation: Psychopharmacology (Berl). 2005 Aug;181(1):8-15
references.pmid: 15830234
references.citation: Stress. 2005 Dec;8(4):247-57
references.pmid: 16423713
references.citation: Neurosci Biobehav Rev. 2007;31(2):172-80
references.pmid: 16956661
references.citation: Pharmacol Biochem Behav. 2007 Feb;86(2):334-45
references.pmid: 17101171
references.citation: Psychoneuroendocrinology. 2007 Jul;32(6):636-50
references.pmid: 17553622
references.citation: Eur J Neurosci. 2008 Jun;27(12):3292-8
references.pmid: 18554293
references.citation: Dev Neurobiol. 2008 Oct;68(12):1429-40
references.pmid: 18726913
references.citation: Neurosci Biobehav Rev. 2009 Apr;33(4):498-507
references.pmid: 18457877
references.citation: Compr Psychiatry. 2009 Jul-Aug;50(4):299-306
references.pmid: 19486727
references.citation: Hippocampus. 2009 Jul;19(7):623-32
references.pmid: 19115376
references.citation: Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S217-26
references.pmid: 19553026
references.citation: Int J Neuropsychopharmacol. 2010 Mar;13(2):191-205
references.pmid: 20047713
references.citation: Neurosci Biobehav Rev. 2010 May;34(6):821-34
references.pmid: 19751762
references.citation: Horm Behav. 2010 Apr;57(4-5):405-14
references.pmid: 20100487
references.citation: J Neurosci. 2010 Jul 7;30(27):9140-4
references.pmid: 20610747
references.citation: Neurosci Lett. 2010 Jul 26;479(2):112-7
references.pmid: 20493239
references.citation: Brain Res. 2010 Aug 19;1349:162-73
references.pmid: 20599824
references.citation: Horm Behav. 2010 Nov;58(5):808-19
references.pmid: 20708008
references.citation: Psychopharmacology (Berl). 2011 Mar;214(1):17-31
references.pmid: 20596857
references.citation: J Neuroendocrinol. 2011 Apr;23(4):329-44
references.pmid: 21219484
references.citation: Curr Top Behav Neurosci. 2011;8:97-118
references.pmid: 21769725
references.citation: Addict Biol. 2011 Oct;16(4):624-37
references.pmid: 21521421
references.citation: Psychopharmacology (Berl). 2011 Nov;218(1):131-56
references.pmid: 21850445
references.citation: Alcohol Clin Exp Res. 2011 Mar;35(3):506-15
references.pmid: 21143247
references.citation: Neuropharmacology. 2012 Mar;62(3):1332-41
references.pmid: 21819999
references.citation: Neuroscience. 2012 Mar 1;204:90-103
references.pmid: 22001306
references.citation: Behav Brain Res. 2012 Apr 1;229(1):289-300
references.pmid: 22230114
references.citation: Alcohol. 2012 May;46(3):185-204
references.pmid: 22459871
references.citation: PLoS One. 2012;7(7):e38682
references.pmid: 22808013
references.citation: Neuropharmacology. 2013 May;68:223-31
references.pmid: 22939999