title: Papillary meningioma in the dog: A clinicopathological case series study.
abstract: Papillary meningioma (PM) is one of the most aggressive variants of meningioma in humans and classified as grade III by WHO system. To date, the biological behavior of PM is still not clear in dogs. This study investigated the correlation between histopathological findings of 16 canine PMs and follow up data. Moreover, the expression of doublecortin, E-cadherin, and N-cadherin was investigated by immunohistochemistry. The supratentorial compartment resulted the most common involved. Despite the low grade of histological malignancy, 87.5% of dogs that underwent surgery experienced tumor recurrence. Intratumoral necrosis was observed in a strict correlation with malignancy histological parameter and tumor recurrence. The post-surgery mean survival time was much lower than thus observed in the most common histological subtypes. This data were also confirmed in dogs that received a conservative treatment alone. Tumors with a severe clinical behavior showed a high N-cadherin expression versus a low or absent E-cadherin expression.
authors.affiliation: Department of Veterinary Medicine, University of Perugia, Via S. Costanzo 4, 06126 Perugia, Italy. Electronic address: mandara@unipg.it.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Mandara
authors.affiliation: Department of Veterinary Medicine, University of Perugia, Via S. Costanzo 4, 06126 Perugia, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Reginato
authors.affiliation: Department of Veterinary Medicine, University of Perugia, Via S. Costanzo 4, 06126 Perugia, Italy.
authors.forename: Greta
authors.initials: G
authors.lastname: Foiani
authors.affiliation: "Valdinievole" Veterinary Hospital, Via Nigra 123, 51015 Monsummano Terme, PT, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Baroni
authors.affiliation: "Valdinievole" Veterinary Hospital, Via Nigra 123, 51015 Monsummano Terme, PT, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Poli
authors.affiliation: "Pedrani" Veterinary Clinic, Via Caldierino 14, 36030 Zugliano, VI, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Gasparinetti
authors.affiliation: "I Portoni Rossi" Veterinary Hospital, Via Roma 57/a, 40069 Zola Predosa, BO, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bernardini
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D005260:Female; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008579:Meningioma / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D060787:Neoplasm Grading / Q000662:veterinary
keywords: Biological behavior; Dog; Grading system; Papillary meningioma