title: [Immune homeostasis impairment in acute carbon tetrachloride intoxicated rats corrected by administration of tocopherol acetate and unithiol].
abstract: The results of experiments on noninbred albino rats showed that the acute intoxication with carbon tetrachloride (CT) at a dose of 1 LD50 reduced the parameters of cellular immune response and function of Th1 cells more significantly than the levels of humoral immune response and Th2-lymphocyte function, decreases the blood content of immunoregulatory cytokines IFN-g, IL-2, IL-4 and anti-inflammatory cytokine IL-13, while not changing the concentration of anti-inflammatory cytokine IL-10 and increasing the concentration of pro-inflammatory cytokine IL-6. The application of unithiol, tocopherol acetate, and combinations partially restores the parameters examined. The combined effects of drugs during intoxication with CT does not exceed their separate action.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskiĭ
authors.forename: M S
authors.initials: MS
authors.lastname: Gromov
authors.forename: V V
authors.initials: VV
authors.lastname: Masliakov
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006706:Homeostasis / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects*; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D018793:Interleukin-13 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D051381:Rats; D018417:Th1 Cells / Q000276:immunology; D058408:Th1-Th2 Balance / Q000187:drug effects; D018418:Th2 Cells / Q000276:immunology; D014494:Unithiol / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D018793:Interleukin-13; D007376:Interleukin-2; D015850:Interleukin-6; D016753:Interleukin-10; D015847:Interleukin-4; D014494:Unithiol; D007371:Interferon-gamma; D024502:alpha-Tocopherol