title: [Clinical studies on effect of bone cement filling on articular cartilage of the knee after curettage of giant cell tumor].
abstract: OBJECTIVE
  To evaluate the effect of bone cement filling on articular cartilage injury after curettage of giant cell tumor around the knee.
  
  
  METHODS
  Fifty-three patients with giant cell tumor who accorded with the inclusion criteria were treated between January 2000 and December 2011, and the clinical data were retrospectively analyzed. There were 30 males and 23 females, aged 16-69 years (mean, 34.2 years). The lesion located at the distal femur in 28 cases and at the proximal tibia in 25 cases. According to Campanacci grade, there were 6 patients at grade I, 38 at grade II, and 9 at grade III. Of 53 patients, 42 underwent curettage followed by bone cement filling, and 11 received curettage followed by bone grafts in the subchondral bony area and bone cement filling. Two groups were divided according to whether secondary osteoarthritis occurred or not during postoperative follow-up. The gender, age, lesion site, the subchondral residual bone thickness, tumor cross section, preoperative Campanacci grade, subchondral bone graft, and Enneking function score were compared between 2 groups, and multivariate logistic regression analysis was done.
  
  
  RESULTS
  All incisions healed by first intention. The average follow-up time was 65 months (range, 23-158 months). Of 53 cases, 37 (69.8%) had no osteoarthritis, and 16 (30.2%) had secondary osteoarthritis. Three cases (5.7%) recurred during the follow-up period. Univariate logistic regression analysis showed no significant difference in gender, age, lesion site, and Campanacci grade between 2 groups (P > 0.1); difference was significant in the subchondral residual bone thickness, tumor cross section, Enneking function score, and subchondral bone graft (P < 0.1). The multivariate logistic regression analysis showed that the decreased subchondral residual bone thickness, the increased tumor cross section, and no subchondral bone graft are the risk factors of postoperative secondary osteoarthritis (P < 0.05).
  
  
  CONCLUSIONS
  Curettage of giant cell tumor around the knee followed by bone cement filling can increase the damage of cartilage, and subchondral bone graft can delay or reduce cartilage injury.
authors.forename: Wu
authors.initials: W
authors.lastname: Cao
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Ye
authors.forename: Nong
authors.initials: N
authors.lastname: Lin
authors.forename: Meng
authors.initials: M
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D016025:Bone Transplantation; D002358:Cartilage, Articular; D003475:Curettage / Q000009:adverse effects*; D005260:Female; D005269:Femur; D018212:Giant Cell Tumor of Bone / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005870:Giant Cell Tumors; D006801:Humans; D007717:Knee; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D020127:Recovery of Function; D012189:Retrospective Studies; D013977:Tibia; D055815:Young Adult
chemical_list: D001843:Bone Cements