title: Genetic association between PER3 genetic polymorphisms and cancer susceptibility: a meta-analysis.
abstract: The genes along the circadian pathways control and modulate circadian rhythms essential for the maintenance of physiological homeostasis through self-sustained transcription-translation feedback loops. PER3 (period 3) is a circadian pathway gene and its variants (rs1012477, 4/5-repeat) have frequently been associated with human cancer. The mixed findings, however, make the role of the 2 variants in cancer susceptibility elusive. We aimed in this article to clarify the association of PER3 variants with cancer. We collected genetic data from 8 studies, providing 6149 individuals for rs1012477 and 5241 individuals for 4/5-repeat. Based on the genotype and allele frequency, we chose the fixed-effects model to estimate risk of cancer. Overall analysis did not suggest a global role of rs1012477 in cancer susceptibility. For PER3 4/5-repeat variant, we found a moderate increase in risk of cancer among individuals with the 5-allele compared to individuals with the 4-allele, although this association was not statistically significant (homozygous model: odds ratio [OR] 1.17, 95% confidence interval [CI] 0.81-1.67; recessive model: OR 1.17, 95% CI 0.82-1.67). No substantial heterogeneity was revealed in this analysis. Our meta-analysis provides no evidence supporting a global association of PER3 genetic variants with the incidence of cancer.
authors.affiliation: From the Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Ou
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Ganfeng
authors.initials: G
authors.lastname: Xie
authors.forename: Rina
authors.initials: R
authors.lastname: Sa
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Lisha
authors.initials: L
authors.lastname: Xiang
authors.forename: Houjie
authors.initials: H
authors.lastname: Liang
mesh_terms: D057906:Circadian Clocks; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D056950:Period Circadian Proteins; D011110:Polymorphism, Genetic; D018570:Risk Assessment
chemical_list: C512644:PER3 protein, human; D056950:Period Circadian Proteins
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