title: Antinociceptive Effect of the Essential Oil Obtained from the Leaves of Croton cordiifolius Baill. (Euphorbiaceae) in Mice.
abstract: Croton cordiifolius Baill. is a shrub known as "quebra-faca" and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil. In an ethnobotanical survey in the state of Pernambuco, "quebra-faca" use was cited in 33% of the interviews. Thus, we decided to evaluate the antinociceptive effects of the essential oil from C. cordiifolius (CcEO). Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) and α-phellandrene (15.43%) as major constituents. Antinociceptive activity was evaluated using murine models of chemically induced pain (writhing induced by acetic acid, formalin, capsaicin, and glutamate tests). Opioid and central nervous systems (CNS) involvement were also investigated. Regarding antinociceptive activity, CcEO (50 and 100 mg/kg) reduced the number of writhing responses induced by acetic acid and decreased the licking times in both phases of the formalin test. CcEO also was evaluated in capsaicin- and glutamate-induced nociception. While no effect was observed in the capsaicin test, CcEO (100 mg/kg) was effective in the glutamate test. Naloxone, an opioid antagonist, did not affect the antinociceptive activity of CcEO in writhing test. In conclusion, the antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system.
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Lenise de Morais
authors.initials: Lde M
authors.lastname: Nogueira
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Monalisa Ribeiro
authors.initials: MR
authors.lastname: da Silva
authors.affiliation: Departamento de Antibióticos, Universidade Federal de Pernambuco, Rua Professor Artur de Sá, s/n, 50740-520 Recife, PE, Brazil.
authors.forename: Simone Maria
authors.initials: SM
authors.lastname: Dos Santos
authors.affiliation: Departamento de Antibióticos, Universidade Federal de Pernambuco, Rua Professor Artur de Sá, s/n, 50740-520 Recife, PE, Brazil.
authors.forename: Julianna Ferreira Cavalcanti
authors.initials: JF
authors.lastname: de Albuquerque
authors.affiliation: Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua Alto do Reservatório, s/n, 55608-680 Vitória de Santo Antão, PE, Brazil.
authors.forename: Igor Cavalcanti
authors.initials: IC
authors.lastname: Ferraz
authors.affiliation: Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua Alto do Reservatório, s/n, 55608-680 Vitória de Santo Antão, PE, Brazil.
authors.forename: Thaíse Torres
authors.initials: TT
authors.lastname: de Albuquerque
authors.affiliation: Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua Alto do Reservatório, s/n, 55608-680 Vitória de Santo Antão, PE, Brazil.
authors.forename: Carlos Renato França de Carvalho
authors.initials: CR
authors.lastname: Mota
authors.affiliation: Instituto de Química, Universidade Federal do Rio Grande do Norte, Avenida Senador Salgado Filho 3000, 50078-970 Natal, RN, Brazil.
authors.forename: Renata Mendonça
authors.initials: RM
authors.lastname: Araújo
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Glauce Socorro de Barros
authors.initials: GS
authors.lastname: Viana
authors.affiliation: Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua Alto do Reservatório, s/n, 55608-680 Vitória de Santo Antão, PE, Brazil.
authors.forename: René Duarte
authors.initials: RD
authors.lastname: Martins
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Rua Coronel Nunes de Melo 1127, 60430-270 Fortaleza, CE, Brazil.
authors.forename: Alexandre
authors.identifier: 0000-0002-4546-2976
authors.initials: A
authors.lastname: Havt
authors.affiliation: Departamento de Antibióticos, Universidade Federal de Pernambuco, Rua Professor Artur de Sá, s/n, 50740-520 Recife, PE, Brazil.
authors.forename: Rafael Matos
authors.initials: RM
authors.lastname: Ximenes
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