title: Presenting phenotype of paediatric inflammatory bowel disease in Wessex, Southern England 2010-2013.
abstract: OBJECTIVE
  There has been at least a twofold increase in the incidence of paediatric inflammatory bowel disease (PIBD) over the last 20 years; we report the presenting features from 2010 to 2013 and compare with previous data.
  
  
  METHODS
  All patients diagnosed with PIBD at University Hospitals Southampton from 2010 to 2013 were identified from an in-house database. Data were obtained from paper and electronic notes. Height, weight and BMI SDS are presented as median values (95% CI).
  
  
  RESULTS
  One hundred and seventy-two patients were included (median age at diagnosis 13.5, 115 male); Crohn's disease (CD) - 107, UC - 50, inflammatory bowel disease unclassified (IBDU) - 15. The most common presenting features of CD were abdominal pain (86%), diarrhoea (78.5%) and weight loss (56.1%); 42.1% of patients had all three. In UC blood in stool (92%), diarrhoea (92%) and abdominal pain (88%) were the most common; all three in 76% of patients. CD presented with ileocolonic disease in 52.5%. UC presented with pancolitis in 64%. There was growth delay in CD: height -0.37 (-0.60 to -0.14); weight -1.09 (-1.35 to -0.83). Growth was maintained in UC: height 0.53 (0.19 to 0.87); weight 0.14 (-0.20 to 0.48).
  
  
  CONCLUSIONS
  Paediatric inflammatory bowel disease phenotype remains as extensive despite increasing incidence. Although the classical phenotype is common, a reasonable proportion present with atypical features, normal growth and normal blood markers.
authors.affiliation: Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ashton
authors.affiliation: Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
authors.forename: T
authors.initials: T
authors.lastname: Coelho
authors.affiliation: Human Genetics and Genomic Medicine, University of Southampton, Duthie Building, University Hospital Southampton, Southampton, UK.
authors.forename: S
authors.initials: S
authors.lastname: Ennis
authors.affiliation: Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
authors.forename: A
authors.initials: A
authors.lastname: Batra
authors.affiliation: Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Afzal
authors.affiliation: Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Beattie
mesh_terms: D000293:Adolescent; D004739:England; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008297:Male; D013997:Time Factors
keywords: Crohn's disease; Growth; Inflammatory bowel disease; Inflammatory bowel disease unclassified; Ulcerative colitis