title: Paediatric CT protocol optimisation: a design of experiments to support the modelling and optimisation process.
abstract: In the last decade, several studies have emphasised the need to understand and optimise the computed tomography (CT) procedures in order to reduce the radiation dose applied to paediatric patients. To evaluate the influence of the technical parameters on the radiation dose and the image quality, a statistical model has been developed using the design of experiments (DOE) method that has been successfully used in various fields (industry, biology and finance) applied to CT procedures for the abdomen of paediatric patients. A Box-Behnken DOE was used in this study. Three mathematical models (contrast-to-noise ratio, noise and CTDI vol) depending on three factors (tube current, tube voltage and level of iterative reconstruction) were developed and validated. They will serve as a basis for the development of a CT protocol optimisation model.
authors.affiliation: SANTEC Department, CRP Henri Tudor, 29 Avenue J-f Kennedy, Luxembourg 1855, Luxembourg Université de Lorraine, CRAN, UMR 7039, 34 Cours Léopold, Nancy 54000, France kaddour.rani@tudor.lu.
authors.forename: K
authors.initials: K
authors.lastname: Rani
authors.affiliation: SANTEC Department, CRP Henri Tudor, 29 Avenue J-f Kennedy, Luxembourg 1855, Luxembourg.
authors.forename: A
authors.initials: A
authors.lastname: Jahnen
authors.affiliation: Université de Lorraine, CRAN, UMR 7039, 34 Cours Léopold, Nancy 54000, France.
authors.forename: A
authors.initials: A
authors.lastname: Noel
authors.affiliation: Université de Lorraine, CRAN, UMR 7039, 34 Cours Léopold, Nancy 54000, France.
authors.forename: D
authors.initials: D
authors.lastname: Wolf
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D002648:Child; D003287:Contrast Media; D006801:Humans; D015233:Models, Statistical; D061330:Multidetector Computed Tomography / Q000379:methods* / Q000592:standards; D010372:Pediatrics / Q000379:methods*; D019047:Phantoms, Imaging; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D012107:Research Design; D059629:Signal-To-Noise Ratio; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D003287:Contrast Media