title: Extract of Bowdichia virgilioides and maackiain as larvicidal agent against Aedes aegypti mosquito.
abstract: The larvicidal activities of extracts of three hardwood species (Hymenaea stigonorcapa, Anadenanthera colubrina and Bowdichia virgilioides) against 4th instar larvae of Aedes aegypti were evaluated using WHO guidelines. Extracts of H. stignocarpa and A. colubrina showed weak activity. The highest larvicidal effect was obtained with the cyclohexane extract of the heartwood of B. virgilioides, which caused 100% mortality at concentrations at 50 and 100 µg/mL. Fraction toluene/EtOAc (8:2) from this extract showed larvicidal activity (LC₅₀ = 34.90 ± 1.27 µg/mL). A mixture of two compounds identified as medicarpin and maackiain exhibited a very good larvicidal activity (sub-fraction 2, LC₅₀ = 17.5 ± 1.87 µg/mL) and maackiain showed to be a strong larvicidal compound (LC₅₀ = 21.95 ± 1.34 µg/mL). This result can be of value in the search for new natural larvicidal compounds from other hardwood plant extracts and presents the first report of B. virgilioides being used to control a mosquito vector.
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Patrícia C
authors.initials: PC
authors.lastname: Bezerra-Silva
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Jefferson C
authors.initials: JC
authors.lastname: Santos
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Geanne K N
authors.initials: GK
authors.lastname: Santos
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Kamilla A
authors.initials: KA
authors.lastname: Dutra
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Andrea L B D
authors.initials: AL
authors.lastname: Santana
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil; Instituto Federal de Educação, Ciência e Tecnologia de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Maranhão
authors.affiliation: Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Márcia S
authors.initials: MS
authors.lastname: Nascimento
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. Electronic address: dmafn@ufpe.br.
authors.forename: Daniela M A F
authors.initials: DM
authors.lastname: Navarro
authors.affiliation: Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
authors.forename: Lothar W
authors.initials: LW
authors.lastname: Bieber
mesh_terms: D000330:Aedes / Q000187:drug effects* / Q000254:growth & development; D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D007303:Insect Vectors / Q000187:drug effects / Q000254:growth & development; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D010936:Plant Extracts / Q000494:pharmacology*; D036343:Pterocarpans / Q000494:pharmacology*; D000094162:Phytoalexins
chemical_list: D007306:Insecticides; D010936:Plant Extracts; D036343:Pterocarpans; C047353:medicarpin; D000094162:Phytoalexins; C001449:inermin
keywords: Aedes aegypti; Bowdichia virgilioides; Hardwood; Maackiain; Medicarpin