title: Effect of arginine vasopressin on the cortex edema in the ischemic stroke of Mongolian gerbils.
abstract: Brain edema formation is one of the most important mechanisms of ischemia-evoked cerebral edema. It has been demonstrated that arginine vasopressin (AVP) receptors are involved in the pathophysiology of secondary brain damage after focal cerebral ischemia. In a well-characterized animal model of ischemic stroke of Mongolian gerbils, the present study was undertaken to clear the effect of AVP on cortex edema in cerebral ischemia. The results showed that (1) occluding the left carotid artery of Mongolian gerbils not only decreased the cortex specific gravity (cortex edema) but also increased AVP levels in the ipsilateral cortex (ischemic area) including left prefrontal lobe, left parietal lobe, left temporal lobe, left occipital lobe and left hippocampus for the first 6 hours, and did not change of the cortex specific gravity and AVP concentration in the right cortex (non-ischemic area); (2) there were many negative relationships between the specific gravity and AVP levels in the ischemic cortex; (3) intranasal AVP (50 ng or 200 ng), which could pass through the blood-brain barrier to the brain, aggravated the focal cortex edema, whereas intranasal AVP receptor antagonist-D(CH2)5Tyr(ET)DAVP (2 µg) mitigated the cortex edema in the ischemic area after occluding the left carotid artery of Mongolian gerbils; and (4) either intranasal AVP or AVP receptor antagonist did not evoke that edema in the non-ischemic cortex. The data indicated that AVP participated in the process of ischemia-evoked cortex edema, and the cerebral AVP receptor might serve as an important therapeutic target for the ischemia-evoked cortex edema.
authors.affiliation: Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China. Electronic address: 380748650@qq.com.
authors.forename: Xue-Yan
authors.initials: XY
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Wu
authors.affiliation: Xinjiang Nikanka Biological Ltd., Co., Huocheng, Xinjiang 835207, China; Jiangsu Su Bei People's Hospital, Clinical College, Yangzhou University, Yangzhou, Jiangsu 225001, China; Xinxiang Institute for New Medicine, Standard Technological Co. Ltd., Xinxiang, Henan 453003, China. Electronic address: bcd2009@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Xinjiang Nikanka Biological Ltd., Co., Huocheng, Xinjiang 835207, China.
authors.forename: Fang-Jie
authors.initials: FJ
authors.lastname: Sun
authors.affiliation: Jiangsu Su Bei People's Hospital, Clinical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wang
authors.affiliation: Henan Provincial Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Wang
authors.affiliation: Department of Neurobiology, Second Military Medical University, Shanghai 200433, China.
authors.forename: Bao-Cheng
authors.initials: BC
authors.lastname: Lin
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000473:pathology; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D005849:Gerbillinae; D008297:Male; D020521:Stroke / Q000150:complications* / Q000473:pathology
chemical_list: D001127:Arginine Vasopressin
keywords: Arginine vasopressin; Cortex edema; Ischemic stroke; Mongolian gerbils; Vasopressin receptor