title: N-stearoyltyrosine dipotassium ameliorates high-fat diet-induced obesity in C57BL/6 mice.
abstract: N-stearoyltyrosine dipotassium (NST-2K) as a neuroprotective candidate is currently in preclinical studies in China. This study investigated the anti-obese effect of NST-2K in high-fat diet-induced obese (DIO) mice. The DIO mice were induced from male C57BL/6 mice by feeding high-fat diet for 11-weeks and treated orally with NST-2K for other 4 weeks. The treatments of DIO mice with NST-2K at 60 or 100 mg/kg/day suppressed the body weight gain, decreased both visceral fat weight and adipocyte size without influence on food intake. To evaluate the effect of NST-2K on lipid metabolism, lipid parameters and several key molecules in the plasma, liver, duodenum mucosa and adipose tissue were analyzed. NST-2K ameliorated the low-grade inflammation in liver, inhibited pancreatic lipase activity in duodenum mucosa, activated β-oxidation system and reduced lipogenesis, thus suppressed lipid accumulation in the liver, reduced adipocyte size and improved lipid and carbohydrate metabolism. Overall, without influence on food intake, NST-2K ameliorated high-fat diet-induced obesity via suppressing liver inflammation, inhibiting dietary fat absorption, promoting lipolysis and reducing lipogenesis.
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Shuang-Qi
authors.initials: SQ
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Sha
authors.initials: S
authors.lastname: Yin
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Ke-Jia
authors.initials: KJ
authors.lastname: Le
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Ruo-Lin
authors.initials: RL
authors.lastname: Yang
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Zhao-Xi
authors.initials: ZX
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Shanghai Bio-Innovation Biotechnology Co., Ltd, Shanghai, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Pharmacy, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Electronic address: huaxue@shsmu.edu.cn.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004041:Dietary Fats / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015507:Drugs, Investigational / Q000008:administration & dosage / Q000627:therapeutic use*; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D050155:Lipogenesis / Q000187:drug effects; D008066:Lipolysis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011897:Random Allocation; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019440:Anti-Obesity Agents; D004041:Dietary Fats; D015507:Drugs, Investigational; D005765:Gastrointestinal Agents; D018696:Neuroprotective Agents; D014443:Tyrosine; C087584:N-stearoyltyrosine; D008049:Lipase
keywords: Anti-inflammation; Diet-induced obesity; N-stearoyltyrosine dipotassium; β-oxidation