title: Evaluation of Mucosal Healing in Ulcerative Colitis by Fecal Calprotectin Vs. Fecal Immunochemical Test.
abstract: OBJECTIVE
  We previously showed that a quantitative fecal immunochemical test (FIT) can predict mucosal healing (MH) in ulcerative colitis (UC). Fecal calprotectin (Fcal) has also been reported as an important biomarker of UC activity. The aim of this study was to compare the predictive ability of these two fecal markers for MH in UC.
  
  
  METHODS
  FIT and Fcal were examined in stool samples from consecutive UC patients who underwent colonoscopy. Mucosal status was assessed via the Mayo endoscopic subscore (MES).
  
  
  RESULTS
  In total, 105 colonoscopies in 92 UC patients were evaluated in conjunction with the FIT and Fcal results. Both FIT and Fcal results were significantly correlated with MES (Spearman's rank correlation coefficient: 0.61 and 0.58, respectively). The sensitivity and specificity of the FIT values (<100 ng/ml) for predicting MH (MES 0 alone) were 0.95 and 0.62, respectively, whereas those of Fcal (<250 μg/g) were 0.82 and 0.62, respectively. The sensitivities became similar when MH was defined as MES 0 or 1 (0.86 vs. 0.86). Although the predictability of MH evaluated by the area under the receiver operating characteristics curve was similar for the two fecal markers (FIT 0.83 vs. Fcal 0.82 for MES 0 alone), the FIT results were relatively robust regardless of the cutoff value selected.
  
  
  CONCLUSIONS
  Both FIT and Fcal can efficiently predict MH in UC, but FIT appears to be more sensitive than Fcal for predicting MES 0 alone.
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shiho
authors.initials: S
authors.lastname: Takashima
authors.affiliation: Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Hiraoka
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Nakarai
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takei
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Inokuchi
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Sugihara
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Takahara
authors.affiliation: Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Harada
authors.affiliation: Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.affiliation: Department of Pathology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D003093:Colitis, Ulcerative / Q000378:metabolism* / Q000473:pathology; D003113:Colonoscopy; D005243:Feces / Q000737:chemistry*; D005260:Female; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007120:Immunochemistry; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D039841:Leukocyte L1 Antigen Complex / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014945:Wound Healing; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D039841:Leukocyte L1 Antigen Complex
references.citation: Inflamm Bowel Dis. 2013 Feb;19(2):332-41
references.pmid: 23328771
references.citation: Am J Med. 1997 Jun;102(6):551-4
references.pmid: 9217670
references.citation: Inflamm Bowel Dis. 2013 Apr;19(5):1034-42
references.pmid: 23470502
references.citation: Gastrointest Endosc. 2012 Jul;76(1):136-43
references.pmid: 22726472
references.citation: Inflamm Bowel Dis. 2010 Feb;16(2):338-46
references.pmid: 19637362
references.citation: Inflamm Bowel Dis. 2013 Apr;19(5):1043-52
references.pmid: 23511035
references.citation: Turk J Gastroenterol. 2012;23(5):509-14
references.pmid: 23161295
references.citation: World J Gastroenterol. 2014 Dec 28;20(48):18367-74
references.pmid: 25561804
references.citation: Lancet Oncol. 2011 Jun;12(6):551-8
references.pmid: 21592859
references.citation: N Engl J Med. 1987 Dec 24;317(26):1625-9
references.pmid: 3317057
references.citation: Inflamm Bowel Dis. 2013 Nov;19(12):2568-76
references.pmid: 24013361
references.citation: Inflamm Bowel Dis. 2014 Feb;20(2):307-14
references.pmid: 24374878
references.citation: Gastroenterology. 2011 Oct;141(4):1194-201
references.pmid: 21723220
references.citation: Aliment Pharmacol Ther. 2013 May;37(10):998-1004
references.pmid: 23521659
references.citation: Am J Gastroenterol. 2005 Nov;100(11):2519-25
references.pmid: 16279909
references.citation: Inflamm Bowel Dis. 2012 Dec;18(12):2218-24
references.pmid: 22344983
references.citation: Am J Gastroenterol. 2013 Jan;108(1):83-9
references.pmid: 23007005
references.citation: J Crohns Colitis. 2011 Oct;5(5):477-83
references.pmid: 21939925
references.citation: Inflamm Bowel Dis. 2012 Jun;18(6):1006-10
references.pmid: 21830282
references.citation: Eur J Intern Med. 2011 Dec;22(6):621-5
references.pmid: 22075292
references.citation: J Crohns Colitis. 2011 Oct;5(5):484-98
references.pmid: 21939926
references.citation: World J Gastroenterol. 2010 Mar 7;16(9):1110-4
references.pmid: 20205282
references.citation: Gut. 2000 Sep;47(3):404-9
references.pmid: 10940279
references.citation: Inflamm Bowel Dis. 2009 Dec;15(12):1851-8
references.pmid: 19462421
references.citation: Int J Colorectal Dis. 2007 Apr;22(4):429-37
references.pmid: 16838143