title: Nalbuphine could decrease the rewarding effect induced by tramadol in mice while enhancing its antinociceptive activity.
abstract: Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been used as an analgesic or an adjuvant with morphine to attenuate the development of morphine dependence and rewarding effect. In this study, we investigated the effect of nalbuphine on tramadol rewarding effect and antinociception. Using the conditioned place preference (CPP) paradigm in mice, we demonstrated that co-administration of nalbuphine (7mg/kg, s.c.) with tramadol (70mg/kg, s.c.) during conditioning completely blocked the CPP induced by tramadol. Co-administration of nalbuphine blocked the increase in dopamine level in the nucleus accumbens induced by tramadol. These actions were accompanied by an increase rather than attenuation of the antinociceptive effect of tramadol. These results suggest that nalbuphine could have a great potential as a pharmacotherapy for tramadol abuse.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
authors.forename: Rasha
authors.initials: R
authors.lastname: Abdel-Ghany
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Nabil
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdel-Aal
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabuk University, Saudi Arabia. Electronic address: waled055@yahoo.com.
authors.forename: Waleed
authors.initials: W
authors.lastname: Barakat
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D008297:Male; D051379:Mice; D009266:Nalbuphine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D010147:Pain Measurement; D012201:Reward; D014147:Tramadol / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D014147:Tramadol; D009266:Nalbuphine; D004298:Dopamine
keywords: Nalbuphine; Psychological dependence; Reward; Tramadol