title: Crystal structure of N-{N-[N-acetyl-(S)-leuc-yl]-(S)-leuc-yl}norleucinal (ALLN), an inhibitor of proteasome.
abstract: The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the mol-ecules in extended conformation of the backbone and engaging all peptide N and O atoms in inter-molecular hydrogen bonds forming an infinite anti-parallel β-sheet.
authors.affiliation: Peptides International, Inc., 11621 Electron Drive, Louisville, KY 40299, USA.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Czerwinski
authors.affiliation: Peptides International, Inc., 11621 Electron Drive, Louisville, KY 40299, USA.
authors.forename: Channa
authors.initials: C
authors.lastname: Basava
authors.affiliation: Leidos Biomedical Research Inc., Basic Science Program, Argonne National Laboratory, Argonne, IL 60439, USA.
authors.forename: Miroslawa
authors.initials: M
authors.lastname: Dauter
authors.affiliation: Synchrotron Radiation Research Section, MCL, National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439, USA.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Dauter
keywords: anti­parallel β-sheet.; crystal structure; hydrogen bonding; proteasome inhib­itor
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