title: Late-Stage Fluorination: From Fundamentals to Application.
abstract: In this brief account, we review work from our lab with a focus on late-stage introduction of fluorine and fluorinated functional groups into small molecules. We attempt to highlight practical developments, which we believe may have potential for industrial applications, and critically reflect on developments that may not yet meet the bar for practical use.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Campbell
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Tobias
authors.initials: T
authors.lastname: Ritter
references.citation: J Am Chem Soc. 2010 Sep 1;132(34):12150-4
references.pmid: 20695434
references.citation: J Am Chem Soc. 2006 Jun 7;128(22):7134-5
references.pmid: 16734446
references.citation: Angew Chem Int Ed Engl. 2011 Sep 19;50(39):9120-3
references.pmid: 21919144
references.citation: J Am Chem Soc. 2012 Oct 24;134(42):17456-8
references.pmid: 23061667
references.citation: J Am Chem Soc. 2010 Mar 24;132(11):3793-807
references.pmid: 20196595
references.citation: Science. 2011 Nov 4;334(6056):639-42
references.pmid: 22053044
references.citation: J Am Chem Soc. 2009 Mar 25;131(11):3796-7
references.pmid: 19249867
references.citation: J Am Chem Soc. 2013 Feb 20;135(7):2552-9
references.pmid: 23384209
references.citation: J Am Chem Soc. 2010 Mar 17;132(10):3268-9
references.pmid: 20163118
references.citation: Chem Sci. 2014 Jan 1;5(1):
references.pmid: 24376910
references.citation: J Am Chem Soc. 2011 Aug 31;133(34):13308-10
references.pmid: 21827148
references.citation: Tetrahedron. 2011 Jun 17;67(24):4449-4454
references.pmid: 21691436
references.citation: Nature. 2002 Mar 21;416(6878):279
references.pmid: 11907567
references.citation: J Am Chem Soc. 2013 Sep 25;135(38):14012-5
references.pmid: 24040932
references.citation: J Am Chem Soc. 2013 Feb 20;135(7):2470-3
references.pmid: 23397884
references.citation: PLoS One. 2013;8(3):e59187
references.pmid: 23554994
references.citation: Synthesis (Stuttg). 2010 Jun 1;2010(11):1804-1821
references.pmid: 20953341
references.citation: Angew Chem Int Ed Engl. 2011 Aug 1;50(32):7312-4
references.pmid: 21692157
references.citation: Nature. 2011 May 26;473(7348):470-7
references.pmid: 21614074
references.citation: Nature. 2004 Feb 5;427(6974):561-5
references.pmid: 14765200
references.citation: Acc Chem Res. 2010 Jan 19;43(1):160-71
references.pmid: 19788304
references.citation: Org Lett. 2009 Jul 2;11(13):2860-3
references.pmid: 19507870
references.citation: Chem Rev. 2008 May;108(5):1501-16
references.pmid: 18426240
references.citation: J Am Chem Soc. 2013 Sep 11;135(36):13278-81
references.pmid: 23998528
references.citation: J Am Chem Soc. 2011 Aug 3;133(30):11482-4
references.pmid: 21736304
references.citation: Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6821-4
references.pmid: 20715033
references.citation: Angew Chem Int Ed Engl. 2008;47(32):5993-6
references.pmid: 18604865
references.citation: Science. 2012 Sep 14;337(6100):1322-5
references.pmid: 22984066
references.citation: Chembiochem. 2004 May 3;5(5):571-89
references.pmid: 15122630
references.citation: Acc Chem Res. 2012 Jun 19;45(6):840-50
references.pmid: 22029861
references.citation: J Am Chem Soc. 2010 Dec 15;132(49):17402-4
references.pmid: 21087003
references.citation: Chem Soc Rev. 2008 Feb;37(2):320-30
references.pmid: 18197348
references.citation: J Am Chem Soc. 2011 Oct 12;133(40):15902-5
references.pmid: 21894884
references.citation: Science. 2007 Sep 28;317(5846):1881-6
references.pmid: 17901324
references.citation: Curr Opin Drug Discov Devel. 2008 Nov;11(6):803-19
references.pmid: 18946845
references.citation: Chem Soc Rev. 2008 Feb;37(2):308-19
references.pmid: 18197347
references.citation: Science. 2009 Sep 25;325(5948):1661-4
references.pmid: 19679769
references.citation: J Am Chem Soc. 2008 Aug 6;130(31):10060-1
references.pmid: 18616246
references.citation: J Am Chem Soc. 2012 Jul 4;134(26):10795-8
references.pmid: 22709145
references.citation: J Am Chem Soc. 2009 Feb 11;131(5):1662-3
references.pmid: 19191693