title: Two new eunicellin diterpenoids from the South China Sea gorgonian Muricella sibogae and their bioactivities.
abstract: A systematic re-study on gorgonian Muricella sibogae from South China Sea yielded 10 eunicellin-based diterpenoids including two new ones, sibogins C and D (1 and 2). Their structures were elucidated by extensive spectroscopic analyses (1D and 2D NMR, IR and MS) and by comparison with data reported in literatures. All the isolates were tested for cytotoxic and antifouling activities. Compounds 3 and 5 showed significant antifouling activity against the green mussel Perna viridis, and especially 3 was suggested as a potent low-toxic antifouling agent with a large LC50/EC50 value of 18.6. This was the first report on the antifouling activity of the eunicellin-type diterpenoids against the green mussel.
authors.affiliation: a Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Chinese Ministry of Education , 5 Yushan Road, Qingdao 266003 , Shandong , P.R. China.
authors.forename: Xing-Wang
authors.initials: XW
authors.lastname: Zhang
authors.forename: Xu-Li
authors.initials: XL
authors.lastname: Tang
authors.forename: Hong-Rui
authors.initials: HR
authors.lastname: Yuan
authors.forename: Dan-Qing
authors.initials: DQ
authors.lastname: Feng
authors.forename: Pei
authors.initials: P
authors.lastname: Su
authors.forename: Ping-Lin
authors.initials: PL
authors.lastname: Li
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control*; D049872:Bivalvia / Q000187:drug effects*; D045744:Cell Line, Tumor; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure
chemical_list: D004224:Diterpenes; C476503:eunicellin
keywords: Muricella sibogae; antifouling activity; cytotoxicity; eunicellin-based diterpenoids; gorgonian