title: Phospholipid remodeling and eicosanoid signaling in colon cancer cells.
abstract: Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of colorectal cancers (CRC) by allowing the cells to produce excess inflammatory eicosanoids, such as prostaglandins, thromboxanes and leukotrienes. Over the years, efforts have been made to understand the lipid remodeling pathways and to design anti-cancer drugs targeting the enzymes of eicosanoid biosynthesis. Here, we discuss the recent progress in phospholipid remodeling and eicosanoid biosynthesis in CRC.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Das
authors.forename: Leobarda Robles
authors.initials: LR
authors.lastname: Martinez
authors.forename: Suparna
authors.initials: S
authors.lastname: Ray
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015777:Eicosanoids / Q000276:immunology*; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D009363:Neoplasm Proteins / Q000276:immunology*; D010105:Oxygenases / Q000276:immunology*; D010743:Phospholipids / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D015777:Eicosanoids; D009363:Neoplasm Proteins; D010743:Phospholipids; D010105:Oxygenases
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