title: Quantum dots-based tissue and in vivo imaging in breast cancer researches: current status and future perspectives.
abstract: As the most common malignant tumor for females, breast cancer (BC) is a highly heterogeneous disease regarding biological behaviors. Precisely targeted imaging on BC masses and biomarkers is critical to BC detection, treatment, monitoring, and prognostic evaluation. As an important imaging technique, quantum dots (QDs)-based imaging has emerged as a promising tool in BC researches owe to its outstanding optical properties. However, few reviews have been specifically devoted to discussing applications of QDs-based imaging in BC researches. This review summarized recent promising works in QDs-based tissue and in vivo imaging for BC studies. Physicochemical and optical properties of QDs and its potential applications were briefly described first. Then QDs-based imaging studies in BC were systematically reviewed, including tissue imaging for studying biomarkers interactions, and evaluating prognostic biomarkers, in vivo imaging for mapping axillary lymphatic system, showing BC xenograft tumor, and detecting BC metastases. At last, the future perspectives with special emphasis on the potential clinical applications have also been discussed. Potential applications of QDs-based imaging on clinical BC in the future are mainly focused on tissue study, especially in BC molecular pathology due to its optimal optical properties and quantitative information capabilities on multiple biomarkers.
authors.affiliation: Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, Department of Oncology, Zhongnan Hospital of Wuhan University, No 169, Donghu Road, Wuchang District, Wuhan, 430071, Hubei Province, China.
authors.forename: Lin-Wei
authors.initials: LW
authors.lastname: Wang
authors.forename: Chun-Wei
authors.initials: CW
authors.lastname: Peng
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles; D009362:Neoplasm Metastasis; D011379:Prognosis; D045663:Quantum Dots; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor
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