title: Occurrence of common allergic diseases in children with idiopathic nephrotic syndrome.
abstract: BACKGROUND
  Clinical and immunological studies have consistently shown a possible link between atopy and idiopathic nephrotic syndrome (INS). However, whether allergic diseases occur after INS develops is unknown.
  
  
  METHODS
  From Taiwan's National Health Insurance database, 1340 children with newly diagnosed INS and 5360 non-INS matched controls were identified in 2000-2007. By the end of 2008, the incidences and hazard ratios of four allergic diseases (allergic conjunctivitis, allergic rhinitis, atopic dermatitis, and asthma) were calculated.
  
  
  RESULTS
  The incidence rates of all four allergic diseases were greater in the INS cohort than in the non-INS cohort in all age groups and decreased sharply as age increased in both cohorts. Children with INS had the highest adjusted hazard ratio (4.13; 95% confidence interval [CI], 2.50-6.83) for atopic dermatitis and the lowest adjusted hazard ratio (1.71; 95% CI, 1.39-2.09) for allergic rhinitis. Most of the allergic diseases appeared within 2-6 months after INS developed, and the incidences declined with increasing follow-up duration.
  
  
  CONCLUSIONS
  Allergic disorders are common in children with INS, especially within the first year after diagnosis. The role of INS in the development of allergic disorders should be elucidated to establish innovative disease intervention programs.
authors.affiliation: Children's Hospital, China Medical University Hospital; College of Medicine China Medical University, Taichung, Taiwan.
authors.forename: Chang-Ching
authors.initials: CC
authors.lastname: Wei
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.forename: Te-Chun
authors.initials: TC
authors.lastname: Shen
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003233:Conjunctivitis, Allergic / Q000453:epidemiology; D016208:Databases, Factual; D003876:Dermatitis, Atopic / Q000453:epidemiology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D009313:National Health Programs; D009404:Nephrotic Syndrome / Q000453:epidemiology*; D065631:Rhinitis, Allergic / Q000453:epidemiology; D013624:Taiwan / Q000453:epidemiology
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