title: Protein- and Peptide-drug conjugates: an emerging drug delivery technology.
abstract: Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Recent advancements in the proteomics and recombinant DNA technology, by enabling identification of distinct structural features of proteins and making it feasible to introduce specific functionalities in protein/peptide structure, has made it possible to synthesize high quality protein- and peptide-drug conjugates though a wide variety of coupling techniques. Additionally, use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug. Several protein- and peptide-drug conjugates are currently under clinical trials warranting their huge market potential in near future. Increased understanding in this field will surely enable us to produce high quality protein- and peptide-drug conjugates which will serve therapeutic needs demanded from drug delivery systems in clinical settings.
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
authors.forename: Imran
authors.initials: I
authors.lastname: Vhora
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
authors.forename: Sushilkumar
authors.initials: S
authors.lastname: Patil
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Bhatt
authors.affiliation: Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India. Electronic address: misraan@hotmail.com.
authors.forename: Ambikanandan
authors.initials: A
authors.lastname: Misra
mesh_terms: D000418:Albumins / Q000737:chemistry; D000906:Antibodies / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D057846:Cell-Penetrating Peptides / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005780:Gelatin / Q000737:chemistry; D006801:Humans; D018796:Immunoconjugates / Q000737:chemistry; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D009842:Oligopeptides / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry; D014168:Transferrin / Q000737:chemistry
chemical_list: D000418:Albumins; D000906:Antibodies; D000970:Antineoplastic Agents; D057846:Cell-Penetrating Peptides; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D018796:Immunoconjugates; D009842:Oligopeptides; D034741:RNA, Small Interfering; D014168:Transferrin; C047981:arginyl-glycyl-aspartic acid; D005780:Gelatin
keywords: ADC; Conjugation; Drug conjugate; Linker; PDC; Peptide; Protein