title: Scopolamine-induced convulsions in fasted animals after food intake: sensitivity of C57BL/6J mice and Sprague-Dawley rats.
abstract: Food intake triggers convulsions in fasted BALB/c mice and Wistar albino rats treated with antimuscarinic drugs, scopolamine or atropine. Inbred strain studies have yielded considerable information regarding genetic influences on seizure susceptibility and factors contribute to epileptogenesis in rodents. This study, therefore, investigated sensitivity to antimuscarinic-induced seizures in C57BL/6J mice and Sprague-Dawley rats. Food deprivation for 48h in mice and 52h in rats did not produce strain differences in body weight loss. Fasted animals treated i.p. with 3mg/kg scopolamine developed convulsions after food intake. The incidence of convulsions was indifferent in comparison to BALB/c mice and Wistar albino rats. Number of animals developing stage 5 was more and onset of convulsions was longer in C57BL/6J mice than in BALB/c mice. Strain-related differences in sensitivity to seizures in C57BL/6J mice may need further evaluation for investigating genetic influences on scopolamine-induced seizures.
authors.affiliation: Department of Pharmacology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: engnur@istanbul.edu.tr.
authors.forename: Nurhan
authors.initials: N
authors.lastname: Enginar
authors.affiliation: Department of Physiology, Faculty of Medicine, Yeni Yüzyıl University, Istanbul, Turkey.
authors.forename: Asiye
authors.initials: A
authors.lastname: Nurten
authors.affiliation: Department of Physiology, Faculty of Medicine, Yeni Yüzyıl University, Istanbul, Turkey.
authors.forename: Aslı Zengin
authors.initials: AZ
authors.lastname: Türkmen
authors.affiliation: Department of Neuroscience, Institute for Experimental Medicine (DETAE), Istanbul University, Istanbul, Turkey.
authors.forename: Büyüklü
authors.initials: B
authors.lastname: Çağla
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D018680:Cholinergic Antagonists / Q000633:toxicity*; D004195:Disease Models, Animal; D004435:Eating; D005215:Fasting; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012601:Scopolamine / Q000633:toxicity*; D012640:Seizures / Q000209:etiology*; D013045:Species Specificity
chemical_list: D018680:Cholinergic Antagonists; D012601:Scopolamine
keywords: Fasting; Food deprivation; Food intake; Scopolamine-induced convulsions; Strain difference