title: Sleep and oligodendrocyte functions.
abstract: Transcriptomic studies have revealed that the brains of sleeping and awake animals differ significantly at the molecular level, with hundreds of brain transcripts changing their expression across behavioral states. However, it was unclear how sleep affects specific cells types, such as oligodendrocytes, which make myelin in the healthy brain and in response to injury. In this review, I summarize the recent findings showing that several genes expressed at higher levels during sleep are involved in the synthesis/maintenance of all membranes and of myelin in particular. In addition, I will discuss the effect of sleep and wake on oligodendrocyte precursor cells (OPCs), providing a working hypothesis on the function of REM sleep and acetylcholine in OPC proliferation.
authors.affiliation: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI.
authors.forename: Michele
authors.initials: M
authors.lastname: Bellesi
keywords: REM sleep; acetylcholine; bacTRAP; multiple sclerosis; myelin; neurogenesis; oligodendrocyte precursor cells; sleep deprivation; wake
references.citation: ASN Neuro. 2011 Mar 10;3(1):e00052
references.pmid: 21288204
references.citation: Neuron. 2014 Jan 8;81(1):12-34
references.pmid: 24411729
references.citation: Nat Neurosci. 2014 Jul;17(7):934-42
references.pmid: 24880216
references.citation: Behav Brain Res. 2006 Feb 15;167(1):36-41
references.pmid: 16214238
references.citation: Brain Res Bull. 2006 Apr 28;69(4):375-81
references.pmid: 16624668
references.citation: Sleep. 2008 Jul;31(7):967-77
references.pmid: 18652092
references.citation: J Neurosci. 2011 Jan 12;31(2):538-48
references.pmid: 21228163
references.citation: Psychiatr Danub. 2014 Sep;26(3):249-55
references.pmid: 25191772
references.citation: J Neurosci Res. 1997 Dec 1;50(5):743-54
references.pmid: 9418962
references.citation: Eur J Neurosci. 2000 Apr;12(4):1227-40
references.pmid: 10762352
references.citation: J Neurosci. 2013 Sep 4;33(36):14288-300
references.pmid: 24005282
references.citation: Brain Res. 2005 Dec 14;1065(1-2):53-9
references.pmid: 16309630
references.citation: J Neurosci Res. 2012 Oct;90(10):2043-52
references.pmid: 22715089
references.citation: Glia. 2002 Dec;40(3):283-99
references.pmid: 12420309
references.citation: J Neurochem. 1990 Aug;55(2):602-10
references.pmid: 1695242
references.citation: Brain Res. 2000 Dec 8;885(2):303-21
references.pmid: 11102586
references.citation: Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19061-6
references.pmid: 20956316
references.citation: Physiol Rev. 2001 Apr;81(2):871-927
references.pmid: 11274346
references.citation: J Neurosci. 2011 Mar 16;31(11):3953-61
references.pmid: 21411638
references.citation: Cell. 2008 Nov 14;135(4):749-62
references.pmid: 19013282
references.citation: Neuron. 1996 Aug;17(2):229-43
references.pmid: 8780647
references.citation: J Neurophysiol. 2005 Dec;94(6):4224-33
references.pmid: 16014798
references.citation: Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):751-6
references.pmid: 18178625
references.citation: Front Cell Neurosci. 2013 Oct 22;7:188
references.pmid: 24155691
references.citation: Sleep. 2013 Oct 01;36(10):1471-81
references.pmid: 24082306
references.citation: Physiol Genomics. 2012 Oct 17;44(20):981-91
references.pmid: 22930738
references.citation: Curr Opin Neurobiol. 2013 Dec;23(6):1065-72
references.pmid: 24094633
references.citation: Science. 1998 Jun 5;280(5369):1610-3
references.pmid: 9616125
references.citation: Neurobiol Aging. 2005 Jun;26(6):939-46
references.pmid: 15718053
references.citation: Sleep. 2014 Apr 01;37(4):723-32
references.pmid: 24899761
references.citation: Behav Brain Res. 2011 Aug 10;221(2):379-88
references.pmid: 21272598
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4643-8
references.pmid: 15070771
references.citation: Neuron. 2009 Sep 24;63(6):865-78
references.pmid: 19778514
references.citation: Nat Rev Neurosci. 2009 Jan;10(1):9-22
references.pmid: 19096367
references.citation: Trends Cell Biol. 2011 Oct;21(10):585-93
references.pmid: 21763137
references.citation: Cell Biol Int. 2004;28(1):63-7
references.pmid: 14759770
references.citation: J Biol Chem. 2008 Jul 25;283(30):20830-40
references.pmid: 18490449
references.citation: Sleep. 1989 Feb;12(1):60-7
references.pmid: 2538911
references.citation: J Physiol. 2003 Jun 1;549(Pt 2):563-71
references.pmid: 12679377
references.citation: Hippocampus. 2008;18(2):182-92
references.pmid: 17960645
references.citation: Nat Rev Neurosci. 2005 Sep;6(9):683-90
references.pmid: 16136172
references.citation: Sleep Med. 2011 Feb;12(2):199
references.pmid: 21276748
references.citation: J Neurosci. 2006 Sep 20;26(38):9722-35
references.pmid: 16988043
references.citation: Front Neurosci. 2010 Oct 21;4:165
references.pmid: 21088695
references.citation: BMC Bioinformatics. 2008 Feb 25;9:118
references.pmid: 18298841
references.citation: Brief Funct Genomic Proteomic. 2006 Dec;5(4):261-72
references.pmid: 16772273
references.citation: J Biol Rhythms. 1999 Dec;14(6):557-68
references.pmid: 10643753
references.citation: Nature. 2012 Apr 29;485(7399):517-21
references.pmid: 22622581
references.citation: Neuron. 2011 May 26;70(4):661-73
references.pmid: 21609823
references.citation: Eur Neurol. 1994;34(6):320-3
references.pmid: 7851452
references.citation: Clin Neurol Neurosurg. 2013 Sep;115(9):1826-30
references.pmid: 23764040
references.citation: Neuroscience. 2005;134(3):721-3
references.pmid: 16054767
references.citation: Cell Mol Life Sci. 2007 May;64(10):1187-204
references.pmid: 17364141
references.citation: Brain Res Bull. 2011 Feb 28;84(3):252-7
references.pmid: 21256199
references.citation: J Neurol Sci. 2011 Oct 15;309(1-2):86-91
references.pmid: 21813138
references.citation: Curr Top Behav Neurosci. 2015;25:151-81
references.pmid: 24218292
references.citation: Genes Dev. 2009 Dec 1;23(23):2729-41
references.pmid: 19952108
references.citation: Sleep Med. 2011 Jun;12(6):614-9
references.pmid: 21570342
references.citation: Neuroscience. 2010 Nov 10;170(4):1140-52
references.pmid: 20727388
references.citation: Biochim Biophys Acta. 2008 Aug;1779(8):486-94
references.pmid: 18590840
references.citation: Neuroscience. 2007 Aug 10;148(1):325-33
references.pmid: 17630219
references.citation: Acta Neurol Scand Suppl. 2013;(196):24-30
references.pmid: 23190288
references.citation: Trends Neurosci. 2001 Jan;24(1):39-47
references.pmid: 11163886
references.citation: Cell Biochem Biophys. 2011 Sep;61(1):179-87
references.pmid: 21455684
references.citation: J Neurosci Res. 2000 Jan 1;59(1):11-8
references.pmid: 10658180
references.citation: J Clin Sleep Med. 2014 Sep 15;10(9):1025-31
references.pmid: 25142763
references.citation: Sleep. 2010 Sep;33(9):1147-57
references.pmid: 20857860
references.citation: Cell Cycle. 2008 Feb 15;7(4):423-7
references.pmid: 18235219
references.citation: J Neurochem. 2006 Sep;98(5):1632-45
references.pmid: 16923172
references.citation: J Neurochem. 2005 Sep;94(5):1411-9
references.pmid: 16001966
references.citation: Neuron. 2004 Jan 8;41(1):35-43
references.pmid: 14715133
references.citation: Nature. 2012 Jul 26;487(7408):443-8
references.pmid: 22801498
references.citation: Hippocampus. 2006;16(3):233-8
references.pmid: 16411244
references.citation: Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):20090-5
references.pmid: 18077435
references.citation: J Neurosci. 2009 Jan 21;29(3):620-9
references.pmid: 19158289
references.citation: J Neurosci Res. 2008 Mar;86(4):766-75
references.pmid: 17960831
references.citation: J Neurochem. 2001 Jun;77(5):1396-406
references.pmid: 11389190
references.citation: Neuroscience. 2006;137(2):593-605
references.pmid: 16257491
references.citation: Neuron. 2007 Jul 19;55(2):217-30
references.pmid: 17640524
references.citation: Dev Neurobiol. 2012 May;72(5):713-28
references.pmid: 21913336
references.citation: PLoS Biol. 2008 Aug 26;6(8):e216
references.pmid: 18752355
references.citation: Sleep. 2008 Feb;31(2):167-75
references.pmid: 18274263