title: Elaborating the role of natural products-induced autophagy in cancer treatment: achievements and artifacts in the state of the art.
abstract: Autophagy is a homeostatic process that is highly conserved across different types of mammalian cells. Autophagy is able to relieve tumor cell from nutrient and oxidative stress during the rapid expansion of cancer. Excessive and sustained autophagy may lead to cell death and tumor shrinkage. It was shown in literature that many anticancer natural compounds and extracts could initiate autophagy in tumor cells. As summarized in this review, the tumor suppressive action of natural products-induced autophagy may lead to cell senescence, provoke apoptosis-independent cell death, and complement apoptotic cell death by robust or target-specific mechanisms. In some cases, natural products-induced autophagy could protect tumor cells from apoptotic death. Technical variations in detecting autophagy affect data quality, and study focus should be made on elaborating the role of autophagy in deciding cell fate. In vivo study monitoring of autophagy in cancer treatment is expected to be the future direction. The clinical-relevant action of autophagy-inducing natural products should be highlighted in future study. As natural products are an important resource in discovery of lead compound of anticancer drug, study on the role of autophagy in tumor suppressive effect of natural products continues to be necessary and emerging.
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong ; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen 518057, China.
authors.forename: Ning
authors.identifier: 0000-0003-1410-329X
authors.initials: N
authors.lastname: Wang
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong ; The University of Hong Kong-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen 518057, China.
authors.forename: Yibin
authors.identifier: 0000-0002-0241-670X
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D016477:Artifacts; D001343:Autophagy / Q000187:drug effects*; D001688:Biological Products / Q000008:administration & dosage*; D019317:Evidence-Based Medicine; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D017063:Outcome Assessment, Health Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001688:Biological Products
references.citation: PLoS One. 2013;8(8):e72748
references.pmid: 24133573
references.citation: Integr Cancer Ther. 2014 May;13(3):226-39
references.pmid: 24525674
references.citation: Oncol Rep. 2013 Feb;29(2):430-6
references.pmid: 23151908
references.citation: J Nutr Biochem. 2013 Apr;24(4):706-12
references.pmid: 22841540
references.citation: Anticancer Drugs. 2013 Oct;24(9):928-36
references.pmid: 23965728
references.citation: Int J Biol Sci. 2014;10(2):212-24
references.pmid: 24550689
references.citation: Free Radic Biol Med. 2010 Jul 15;49(2):214-26
references.pmid: 20398749
references.citation: Carcinogenesis. 2013 Jan;34(1):128-38
references.pmid: 23002236
references.citation: Mol Pharmacol. 2007 Jul;72(1):29-39
references.pmid: 17395690
references.citation: Cell Death Differ. 2012 Jan;19(1):87-95
references.pmid: 22052193
references.citation: Nat Commun. 2013;4:2130
references.pmid: 23945651
references.citation: Cell Death Dis. 2014;5:e1123
references.pmid: 24625982
references.citation: Cell Death Differ. 2005 Nov;12 Suppl 2:1528-34
references.pmid: 16247500
references.citation: Clin Cancer Res. 2007 Dec 15;13(24):7271-9
references.pmid: 18094407
references.citation: Nutr Cancer. 2014;66(3):506-16
references.pmid: 24206214
references.citation: Clin Cancer Res. 2010 Feb 1;16(3):967-77
references.pmid: 20103676
references.citation: Mol Cell. 2014 Jan 23;53(2):167-78
references.pmid: 24462201
references.citation: Int J Mol Sci. 2013;14(1):1370-82
references.pmid: 23344047
references.citation: PLoS One. 2011;6(6):e20849
references.pmid: 21695150
references.citation: J Cell Biochem. 2014 Aug;115(8):1458-66
references.pmid: 24619908
references.citation: Toxicon. 2006 Apr;47(5):521-30
references.pmid: 16542694
references.citation: Evid Based Complement Alternat Med. 2013;2013:385219
references.pmid: 23818925
references.citation: Evid Based Complement Alternat Med. 2013;2013:231874
references.pmid: 23573119
references.citation: Oncol Rep. 2013 May;29(5):2072-8
references.pmid: 23468088
references.citation: J Cell Biochem. 2010 Dec 15;111(6):1426-36
references.pmid: 20830746
references.citation: Int J Cancer. 2009 Feb 1;124(3):511-5
references.pmid: 19003982
references.citation: Trends Endocrinol Metab. 2013 Apr;24(4):209-17
references.pmid: 23474062
references.citation: Toxicol In Vitro. 2013 Sep;27(6):1928-36
references.pmid: 23810952
references.citation: J Ethnopharmacol. 2013 Jul 9;148(2):544-55
references.pmid: 23684722
references.citation: Food Chem. 2013 Dec 15;141(4):3598-605
references.pmid: 23993526
references.citation: Cell Death Dis. 2013;4:e824
references.pmid: 24091667
references.citation: Nat Rev Mol Cell Biol. 2014 Feb;15(2):81-94
references.pmid: 24401948
references.citation: Cancer Sci. 2011 Jul;102(7):1287-92
references.pmid: 21443647
references.citation: Autophagy. 2010 Jul;6(5):642-4
references.pmid: 20495344
references.citation: Evid Based Complement Alternat Med. 2013;2013:514719
references.pmid: 23843876
references.citation: Mol Cancer Ther. 2011 Sep;10(9):1533-41
references.pmid: 21878654
references.citation: Toxicol Lett. 2014 Apr 21;226(2):182-91
references.pmid: 24530352
references.citation: PLoS One. 2014;9(1):e83604
references.pmid: 24427275
references.citation: Cancer. 2009 Nov 15;115(22):5309-18
references.pmid: 19701908
references.citation: Br J Cancer. 2014 Aug 26;111(5):944-54
references.pmid: 24983366
references.citation: Oncol Lett. 2013 Nov;6(5):1435-1438
references.pmid: 24179537
references.citation: Evid Based Complement Alternat Med. 2012;2012:980658
references.pmid: 23320042
references.citation: Int J Gynecol Cancer. 2013 Jun;23(5):803-8
references.pmid: 23532091
references.citation: Clin Cancer Res. 2005 May 1;11(9):3155-62
references.pmid: 15867207
references.citation: Apoptosis. 2014 Jan;19(1):210-23
references.pmid: 24114361
references.citation: Mar Drugs. 2013 Sep;11(9):3500-16
references.pmid: 24048269
references.citation: Cancer Lett. 2014 Mar 28;344(2):239-59
references.pmid: 24280585
references.citation: J Pathol. 2010 May;221(1):3-12
references.pmid: 20225336
references.citation: Biochim Biophys Acta. 2013 Dec;1833(12):2890-9
references.pmid: 23906794
references.citation: Cell Biochem Funct. 2013 Oct;31(7):566-74
references.pmid: 23307628
references.citation: Autophagy. 2010 Nov;6(8):1107-14
references.pmid: 20930570
references.citation: J Ethnopharmacol. 2010 Aug 19;131(1):95-103
references.pmid: 20558270
references.citation: Cancer Sci. 2012 Apr;103(4):684-90
references.pmid: 22192169
references.citation: Autophagy. 2009 Oct;5(7):1018-25
references.pmid: 19652534
references.citation: Mol Cancer Ther. 2010 Mar;9(3):718-30
references.pmid: 20197400
references.citation: Evid Based Complement Alternat Med. 2012;2012:134512
references.pmid: 23193420
references.citation: Cell Death Differ. 2011 Apr;18(4):571-80
references.pmid: 21311563
references.citation: J Clin Invest. 2003 Dec;112(12):1809-20
references.pmid: 14638851
references.citation: Cancer Res. 2010 Oct 1;70(19):7392-9
references.pmid: 20841478
references.citation: J Pharm Pharmacol. 2012 Jan;64(1):146-53
references.pmid: 22150682
references.citation: PLoS One. 2014;9(5):e98703
references.pmid: 24878898
references.citation: Genes Dev. 2011 Apr 1;25(7):717-29
references.pmid: 21406549
references.citation: Cell Death Dis. 2013;4:e804
references.pmid: 24052072
references.citation: Int J Mol Med. 2013 Sep;32(3):577-84
references.pmid: 23857115
references.citation: Br J Pharmacol. 2011 Sep;164(2b):731-42
references.pmid: 21418191
references.citation: Oncotarget. 2014 Feb 15;5(3):577-86
references.pmid: 24583697
references.citation: Int J Oncol. 2012 Oct;41(4):1431-42
references.pmid: 22858649
references.citation: Autophagy. 2011 Sep;7(9):985-92
references.pmid: 21628996
references.citation: Cancer Res. 2014 May 1;74(9):2487-98
references.pmid: 24626093
references.citation: Sci Rep. 2014;4:5510
references.pmid: 24981420
references.citation: Phytother Res. 2014 Mar;28(3):458-64
references.pmid: 23813779
references.citation: Br J Haematol. 2013 Mar;160(5):714-7
references.pmid: 23205612
references.citation: Am J Surg. 2012 Dec;204(6):868-73
references.pmid: 23231930
references.citation: Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):529-42
references.pmid: 18207031
references.citation: Int J Cell Biol. 2012;2012:317645
references.pmid: 22496691
references.citation: J Cell Biochem. 2011 Sep;112(9):2471-9
references.pmid: 21538483
references.citation: Am J Chin Med. 2014;42(1):243-55
references.pmid: 24467547
references.citation: J Biol Chem. 2010 Aug 13;285(33):25570-81
references.pmid: 20529838
references.citation: Int J Oncol. 2012 Apr;40(4):1153-61
references.pmid: 22139054
references.citation: Free Radic Biol Med. 2011 Oct 1;51(7):1365-75
references.pmid: 21763418
references.citation: Biochem Biophys Res Commun. 2014 Jul 18;450(1):247-54
references.pmid: 24887566
references.citation: Food Chem Toxicol. 2013 Sep;59:703-8
references.pmid: 23850994
references.citation: Asian Pac J Cancer Prev. 2012;13(6):2739-44
references.pmid: 22938451
references.citation: J Cell Biol. 1967 May;33(2):437-49
references.pmid: 4292315
references.citation: Int J Oncol. 2013 Mar;42(3):993-1000
references.pmid: 23354080
references.citation: Oncol Rep. 2012 May;27(5):1481-7
references.pmid: 22367117
references.citation: Evid Based Complement Alternat Med. 2013;2013:702869
references.pmid: 23533514
references.citation: J Pharmacol Sci. 2013;123(2):102-9
references.pmid: 24048094
references.citation: BMB Rep. 2014 Dec;47(12):697-702
references.pmid: 24667175
references.citation: Phytomedicine. 2013 Jan 15;20(2):159-65
references.pmid: 23141426
references.citation: J Cell Physiol. 2012 May;227(5):2196-206
references.pmid: 21866552
references.citation: Autophagy. 2011 Feb;7(2):176-87
references.pmid: 21081844
references.citation: Nutr Cancer. 2014;66(3):435-40
references.pmid: 24579778
references.citation: Cancer Res. 2011 Dec 15;71(24):7537-46
references.pmid: 22037873
references.citation: J Biol Chem. 2014 Apr 11;289(15):10607-19
references.pmid: 24599950
references.citation: Cell Death Dis. 2013;4:e720
references.pmid: 23846222
references.citation: Autophagy. 2012 Apr;8(4):445-544
references.pmid: 22966490
references.citation: Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75
references.pmid: 20716633
references.citation: Mol Med Rep. 2014 Jul;10(1):441-6
references.pmid: 24788478
references.citation: Autophagy. 2014 May;10(5):736-49
references.pmid: 24642486
references.citation: Clin Geriatr Med. 2009 Nov;25(4):715-32, ix
references.pmid: 19944269
references.citation: BMC Complement Altern Med. 2013;13:233
references.pmid: 24053190
references.citation: Autophagy. 2014 Feb;10(2):296-310
references.pmid: 24389959
references.citation: Int J Oncol. 2014 Dec;45(6):2331-40
references.pmid: 25231051
references.citation: J Cell Biochem. 2012 Nov;113(11):3476-85
references.pmid: 22689083
references.citation: Trends Mol Med. 2013 Jul;19(7):428-46
references.pmid: 23714574
references.citation: Oncol Lett. 2010 May;1(3):489-493
references.pmid: 22966330
references.citation: Nutr Cancer. 2010;62(5):630-40
references.pmid: 20574924
references.citation: PLoS One. 2013;8(8):e71672
references.pmid: 23967233
references.citation: BMC Cancer. 2011;11:183
references.pmid: 21595977
references.citation: Nature. 1999 Dec 9;402(6762):672-6
references.pmid: 10604474
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52
references.pmid: 17548692
references.citation: Int J Oncol. 2013 Jul;43(1):338-48
references.pmid: 23677253
references.citation: J Asian Nat Prod Res. 2009 Nov;11(11):918-28
references.pmid: 20183254
references.citation: PLoS One. 2014;9(2):e88140
references.pmid: 24505404
references.citation: Front Oncol. 2014 Apr 14;4:64
references.pmid: 24782981
references.citation: PLoS One. 2013;8(6):e65250
references.pmid: 23762328
references.citation: Cell Metab. 2011 May 4;13(5):495-504
references.pmid: 21531332
references.citation: J Exp Clin Cancer Res. 2013;32:57
references.pmid: 23958461
references.citation: PLoS One. 2011;6(12):e28780
references.pmid: 22205968
references.citation: Cell. 2009 Jun 12;137(6):1062-75
references.pmid: 19524509
references.citation: Toxicol Lett. 2006 Jun 20;164(1):24-36
references.pmid: 16371244
references.citation: Int J Oncol. 2013 Dec;43(6):1943-50
references.pmid: 24141596
references.citation: Carcinogenesis. 2013 Jun;34(6):1331-42
references.pmid: 23393227
references.citation: Int J Mol Med. 2012 Oct;30(4):939-44
references.pmid: 22824846
references.citation: J Nat Prod. 2012 Apr 27;75(4):586-90
references.pmid: 22439644
references.citation: Biochem Biophys Res Commun. 2010 Jan 1;391(1):903-8
references.pmid: 19951696
references.citation: Autophagy. 2008 Nov;4(8):1020-33
references.pmid: 18838862
references.citation: Cancer Biol Ther. 2014 Apr;15(4):473-8
references.pmid: 24496081