title: Effects of intravenously administered indocyanine green on near-infrared cerebral oximetry and pulse oximetry readings.
abstract: BACKGROUND
  Intravenously administered indocyanine green (ICG) may cause misreadings of cerebral oximetry and pulse oximetry in patients undergoing carotid endarterectomy under general anesthesia. The present study determined the effects of two different doses (12.5 mg vs. 25 mg) of ICG on regional cerebral tissue oxygen saturation (SctO2) and percutaneous peripheral oxygen saturation (SpO2).
  
  
  METHODS
  Twenty-six patients receiving ICG for videoangiography were divided into two groups according to the dosage (12.5 mg and 25 mg, n = 13 in each group). Heart rate, arterial blood pressure, SctO2, and SpO2 were measured before and after an intravenous bolus administration of ICG.
  
  
  RESULTS
  Following the dye administration, no changes in heart rate or arterial blood pressure were noted in either group. SctO2 was increased in both groups; however, the magnitude of the increase was greater (21.6 ± 5.8% vs. 12.6 ± 4.1%, P < 0.0001) and more prolonged (28.4 ± 9.6 min vs. 13.8 ± 5.2 min, P < 0.0001) in the 25 mg group than in the 12.5 mg group. In contrast, SpO2 was decreased in both groups; the magnitude of the decrease was greater in the 25 mg group than in the 12.5 mg group (4.0 ± 0.8% vs. 1.6 ± 1.0%, P < 0.0001). There were no differences in the time to reach the peak SctO2 or to reach the nadir SpO2 between the two groups.
  
  
  CONCLUSIONS
  In patients given ICG for videoangiography, a 25 mg bolus results in a greater and more prolonged increase in SctO2 and a greater reduction in SpO2 than a 12.5 mg bolus, with no differences in the time to reach the peak SctO2 or to reach the nadir SpO2.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Ho Young
authors.initials: HY
authors.lastname: Baek
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Joung Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Cho
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Seongtae
authors.initials: S
authors.lastname: Jeong
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Kyung Yeon
authors.initials: KY
authors.lastname: Yoo
keywords: Cerebral oximetry; Cerebral oxygenation; Indocyanine green; Near-infrared spectroscopy; Pulse oximetry
references.citation: J Neurosurg. 2005 Dec;103(6):982-9
references.pmid: 16381184
references.citation: Anesth Analg. 2012 Dec;115(6):1373-83
references.pmid: 23144435
references.citation: J Clin Monit. 1989 Apr;5(2):135-6
references.pmid: 2656924
references.citation: J Neurosurg Anesthesiol. 2002 Jul;14(3):218-22
references.pmid: 12172295
references.citation: Anesthesiology. 1986 Nov;65(5):550-2
references.pmid: 3777490
references.citation: J Biomed Opt. 2007 May-Jun;12(3):034036
references.pmid: 17614744
references.citation: Eur J Vasc Endovasc Surg. 2013 Oct;46(4):397-403
references.pmid: 23973277
references.citation: Curr Med Chem. 2014;21(16):1871-97
references.pmid: 24350844
references.citation: Anesth Analg. 2002 Mar;94(3):586-90; table of contents
references.pmid: 11867380
references.citation: Anesthesiology. 2012 Apr;116(4):834-40
references.pmid: 22343469
references.citation: Anesth Analg. 2007 Sep;105(3):704-6
references.pmid: 17717227
references.citation: Liver Cancer. 2012 Jun;1(1):15-21
references.pmid: 24159568
references.citation: Int J Biomed Imaging. 2012;2012:940585
references.pmid: 22577366
references.citation: J Neurosurg. 2005 Apr;102(4):692-8
references.pmid: 15871512
references.citation: J Neurosurg Anesthesiol. 2015 Jan;27(1):57-60
references.pmid: 24922336
references.citation: Anesthesiology. 2000 Oct;93(4):947-53
references.pmid: 11020744
references.citation: Anesth Analg. 2007 Aug;105(2):549-50
references.pmid: 17646539
references.citation: Cerebrovasc Dis. 2012;34(4):314-21
references.pmid: 23146912
references.citation: J Clin Monit. 1987 Oct;3(4):249-56
references.pmid: 3681358
references.citation: Br J Anaesth. 2009 Dec;103 Suppl 1:i3-13
references.pmid: 20007987
references.citation: Acta Neurochir (Wien). 2011 Aug;153(8):1641-4; discussion 1644
references.pmid: 21499960
references.citation: World J Surg. 1995 Jan-Feb;19(1):113-8; discussion 118
references.pmid: 7740796