title: [Spatial organization of interphase chromosomes and the role of chromatin fiber dynamycs in the positioning of genome elements].
abstract: Many studies are devoted to the analysis ofinterphase chromosome architecture due to the evidence of functional-dependent spatial organization of the genome. These studies are based on classical cytological methods as well as on biochemical approaches (3C, 4C, 5C, Hi-C) allowing for the detection of long-range interactions between fragments of chromatin fibers, including the genome-wide interactions. In this review, we discuss the results of these researches which make it possible to explain functional-dependent multilevel compartmentalization of the nucleous and unravel the principals of high-level chromatin organization. Special attention is paid to the enchancer-promoter interactions important for the regulation of gene expression. Accordingly, we consider the model of an active chromatin hub and the alternative model of an active chromatin compartment, which was proposed based on reconsideration of some steps of the 3C procedure.
authors.forename: E S
authors.initials: ES
authors.lastname: Gushchanskaya
authors.forename: A A
authors.initials: AA
authors.lastname: Gavrilov
authors.forename: S V
authors.initials: SV
authors.lastname: Razin
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D016678:Genome; D006801:Humans; D007399:Interphase
chemical_list: D002843:Chromatin