title: The lncRNA Pnky in the brain.
abstract: Long noncoding RNAs (lncRNAs) influence diverse cellular processes and have been implicated in regulating stem cell properties. Now in Cell Stem Cell, Ramos et al. (2015) demonstrate that the neural-specific lncRNA Pnky regulates neuronal differentiation from neural stem cells and mediates RNA splicing through interactions with polypyrimidine tract-binding protein 1 (PTBP1).
authors.affiliation: Department of Pharmacology and Catholic Neuroscience Institute, School of Medicine, the Catholic University of Korea, Seoul 137-701, South Korea.
authors.forename: Kyung-Ok
authors.initials: KO
authors.lastname: Cho
authors.affiliation: Department of Molecular Biology and Hamon Center for Regenerative Science and Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jenny.hsieh@utsouthwestern.edu.
authors.forename: Jenny
authors.initials: J
authors.lastname: Hsieh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D053595:Embryonic Stem Cells / Q000502:physiology*; D034441:Heterogeneous-Nuclear Ribonucleoproteins / Q000378:metabolism*; D006801:Humans; D058953:Neural Stem Cells / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D038941:Polypyrimidine Tract-Binding Protein / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000378:metabolism*
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D062085:RNA, Long Noncoding; D038941:Polypyrimidine Tract-Binding Protein