title: Self-assembled sorbitol-derived supramolecular hydrogels for the controlled encapsulation and release of active pharmaceutical ingredients.
abstract: A simple supramolecular hydrogel based on 1,3:2,4-di(4-acylhydrazide)benzylidene sorbitol (DBS-CONHNH2), is able to extract acid-functionalised anti-inflammatory drugs via directed interactions with the self-assembled gel nanofibres. Two-component hydrogel-drug hybrid materials can be easily formed by mixing and exhibit pH-controlled drug release.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK. david.smith@york.ac.uk.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Howe
authors.forename: Babatunde O
authors.initials: BO
authors.lastname: Okesola
authors.forename: David K
authors.initials: DK
authors.lastname: Smith
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000378:metabolism; D001597:Benzylidene Compounds / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057139:Nanofibers / Q000737:chemistry / Q000648:ultrastructure; D013012:Sorbitol / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D001597:Benzylidene Compounds; D004337:Drug Carriers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D013012:Sorbitol