title: Vitamin D and cardiometabolic risk factors in adult non-diabetic offspring of type 2 diabetic parents.
abstract: OBJECTIVE
  To measure serum vitamin D levels and assess its correlation with the various components of metabolic syndrome in adult non-diabetic offsprings of type 2 diabetics.
  
  
  METHODS
  The analytical cross-sectional study was conducted from February to December 2012 at the Department of Physiology and Cell Biology, University of Health Sciences, Lahore. Data on anthropometric and physiologic/biochemical parameters was collected. Fasting blood samples were collected and serum was analysed for fasting serum insulin, fasting blood sugar, lipid profile and vitamin D. SPSS 20 was used for statistical analysis.
  
  
  RESULTS
  Of the total 88 subjects in the study, 40 (45.5%) were offsprings of type 2 diabetics and 48 (54.5%) were offsprings of non-diabetic parents. Vitamin D deficiency (<20 ng/ml) was observed in 86 (98.5%) of the subjects and 77 (87.5%) had vitamin D levels <15 ng/ml. Severe deficiency (<10 ng/ml) was seen in 61 (70%) subjects. Inverse correlation was observed between vitamin D and low density lipoprotein, total cholesterol, total cholesterol/high density lipoprotein ratio, Fasting Blood Sugar and homeostasis model assessment of insulin resistance.
  
  
  CONCLUSIONS
  The subjects were severely deficient in vitamin D and its levels were inversely correlated with most of the components of metabolic syndrome.
authors.forename: Mudassar Ali
authors.initials: MA
authors.lastname: Roomi
authors.forename: Khalid Parvez
authors.initials: KP
authors.lastname: Lone
authors.forename: Ansa
authors.initials: A
authors.lastname: Madassar
mesh_terms: D000328:Adult; D032721:Adult Children; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D008055:Lipids