title: The Dixon technique and the frequency-selective fat suppression technique in three-dimensional T1 weighted MRI of the liver: a comparison of contrast-to-noise ratios of hepatocellular carcinomas-to-liver.
abstract: OBJECTIVE
  The use of three-dimensional T1 weighted gradient echo sequences such as the Dixon technique and the frequency-selective fat suppression (FS) technique is currently widely accepted method in MRI examinations of the liver. To assess the image qualities of the Dixon technique and the frequency-selective FS technique, the contrast-to-noise ratios (CNRs) of hepatocellular carcinoma (HCC)-to-liver and fat-to-liver were compared between the two techniques in the hepatobiliary phase (HBP) following administration of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid.
  
  
  METHODS
  MR images of 59 patients with a total of 86 HCCs were retrospectively evaluated. Images were consecutively obtained with the Dixon and frequency-selective FS methods in the HBP and their CNRs of HCC-to-liver and fat-to-liver were compared. CNRs and contrast ratios were calculated by the mean value of the liver parenchyma, HCC, fat and standard deviation of the liver parenchyma. The Wilcoxon signed-ranks test was used for statistical analysis.
  
  
  RESULTS
  The median CNRs for the frequency-selective FS and Dixon techniques of HCC-to-liver were 4.3 and 5.4 (p < 0.01), mesenteric fat-to-liver were 9.9 and 12.8 (p < 0.01) and subcutaneous fat-to-liver were 9.9 and 13.2 (p < 0.01), respectively.
  
  
  CONCLUSIONS
  The Dixon technique yielded higher CNRs of HCC-to-liver than that of the frequency-selective FS technique.
  
  
  CONCLUSIONS
  There are a limited number of reports on quantitative analysis of the image qualities of the Dixon technique and the frequency-selective FS technique, particularly within the same patient and examination.
authors.affiliation: 1 Department of Radiology, Osaka Red Cross Hospital, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takatsu
authors.forename: T
authors.initials: T
authors.lastname: Akasaka
authors.forename: T
authors.initials: T
authors.lastname: Miyati
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D021621:Imaging, Three-Dimensional; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
references.citation: J Hepatol. 2012 Apr;56(4):908-43
references.pmid: 22424438
references.citation: J Magn Reson Imaging. 2008 Jun;27(6):1448-54
references.pmid: 18504735
references.citation: Magn Reson Med. 1999 Nov;42(5):952-62
references.pmid: 10542355
references.citation: J Magn Reson Imaging. 2010 Jan;31(1):4-18
references.pmid: 20027567
references.citation: J Magn Reson Imaging. 2010 Apr;31(4):889-94
references.pmid: 20373433
references.citation: Magn Reson Med. 2011 Jan;65(1):96-107
references.pmid: 20860006
references.citation: J Comput Assist Tomogr. 2011 Jan-Feb;35(1):96-101
references.pmid: 21160433
references.citation: J Magn Reson Imaging. 2008 Sep;28(3):543-58
references.pmid: 18777528
references.citation: J Magn Reson Imaging. 2008 Oct;28(4):946-56
references.pmid: 18821620
references.citation: AJR Am J Roentgenol. 2009 Apr;192(4):915-22
references.pmid: 19304695
references.citation: Magn Reson Med. 2011 Apr;65(4):994-1004
references.pmid: 21413063
references.citation: MAGMA. 2002 Mar;14(1):10-9
references.pmid: 11796248
references.citation: Magn Reson Med. 2004 Aug;52(2):376-90
references.pmid: 15282821
references.citation: Radiology. 1984 Oct;153(1):189-94
references.pmid: 6089263
references.citation: Magn Reson Imaging. 1984;2(3):193-204
references.pmid: 6530926
references.citation: Magn Reson Med. 2005 Jan;53(1):177-85
references.pmid: 15690517
references.citation: Magn Reson Med. 2005 Sep;54(3):748-54
references.pmid: 16088885
references.citation: NMR Biomed. 2006 May;19(3):368-78
references.pmid: 16705638
references.citation: Radiology. 2007 Jun;243(3):908-9
references.pmid: 17517947
references.citation: Radiology. 2007 Dec;245(3):638-9
references.pmid: 18024445
references.citation: J Magn Reson Imaging. 2013 Aug;38(2):401-10
references.pmid: 23292998