title: Impact of nuclear factor erythroid-derived 2-like 2 and p62/sequestosome expression on prognosis of patients with gliomas.
abstract: The objective of the present study was to determine whether 2 proteins (nuclear erythroid 2-related factor 2 [Nrf2] and p62) can be used as the biomarkers for prognosis of gliomas. The glioma samples were from 75 glioma patients after surgery. The expression of Nrf2 and p62 in 75 samples was detected with immunohistochemical staining. The correlation between immunohistochemical results and clinicopathological parameters or prognosis was analyzed. The results indicated that high Nrf2 expression was detected in 61.3% of glioma tissue samples and was significantly correlated with age (P = .006), tumor grade (P = .002), and onset time (P = .019). The overall survival (OS) and disease-free survival (DFS) in patients with high Nrf2 expression were significantly shorter than those in patients with low Nrf2 expression (P < .001). High p62 expression was detected in 65.3% of glioma tissue samples, and p62 expression was correlated significantly with the tumor grade (P < .001) and 1-year survival (P = .024). OS and DFS in patients with high p62 expression were significantly shorter than those in patients with low p62 expression (P < .001). Spearman rank correlation test revealed a significant positive relation between Nrf2 and p62 expressions (r = 0.515, P < .001). Multivariate regression analysis showed that p62 expression and age were the significant independent prognostic factors for DFS (P < .05) and tumor grade and p62 expression were independent prognostic parameters for OS (P < .01 or P < .05). These findings indicated that p62 may be used as the prognostic biomarker in patients with gliomas.
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
authors.forename: Mingfei
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China.
authors.forename: Hangdi
authors.initials: H
authors.lastname: Xu
authors.affiliation: Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
authors.forename: Buyi
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hong
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China. Electronic address: ywisyw@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.affiliation: Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China. Electronic address: zjm135@vip.sina.com.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D055815:Young Adult
chemical_list: D015415:Biomarkers; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human
keywords: Gliomas; Nrf2; Prognosis; Survival; p62