title: A Viscidane Diterpene and Polyacetylenes from Cultures of Hypsizygus marmoreus.
abstract: Investigation on the cultures of Hypsizygus marmoreus resulted in the isolation of a new viscidane diterpene, 8-oxoviscida-3,11(18)-diene-13,14,15,19-tetraol (1) and two new polyacetylenes, (E)-10-(1,1-dimethyl-2-propenyloxy)-2-decene-4,6,8-triyn-1-ol (2) and 10-(1,1-dimethyl-2-propenyloxy)deca-4,6,8-triyn-1-ol (3), together with two known polyacetylenes, (E)-2-decen-4,6,8-triyn-1-ol (4) and 4,6,8-decatriyn-1-ol (5). Their structures were elucidated on the basis of extensive spectroscopic studies. Compound 1 is the first finding of viscidane diterpene in mushrooms. Compounds 1, 3 and 5 were tested for cytotoxicity against human tumor cell lines HL-60, SMMC-7721, A-549, MCF-7 and SW-480. None of the compounds showed cytotoxic activity (IC50> 40 µM).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.forename: Ze-Jun
authors.initials: ZJ
authors.lastname: Dong
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
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