title: CT-based renal volume and graft function after living-donor kidney transplantation: Is there a volume threshold to avoid?
abstract: OBJECTIVE
  Donated kidney volume influences post-transplant outcomes and graft survival. We evaluated the relationship between living-donor kidney volume and recipient graft function at 12 months post-transplantation, exploring a volume threshold for a suboptimal graft function, and compared two different formulas of volume estimation.
  
  
  METHODS
  A retrospective analysis of 82 pairs of living-donor kidney transplants was conducted. Donor renal volumes were estimated from computerized tomography scans using the ellipsoid formula and the voxel counting technique. Linear and restricted cubic regression spline was used to analyze the association of volume with graft function. Additionally, we determined the correlation between the two volume estimation formulas and established a correction factor for the ellipsoid formula.
  
  
  RESULTS
  Renal volume (adjusted to recipient BSA) had the strongest independent effect (B = 1.65 per 10 ml/m(2) increase, p value <0.001) on graft function at 12 months. The eGFR at 12 months was 52.5, 63.6 and 67.6 ml/min/1.73 m(2) for the low, medium and high volume ratio terciles, respectively (p value <0.001). The odds of a GFR <50 ml/min became significantly reduced with volumes above 145 cc/1.73 m(2). A strong positive correlation between the two formulas was identified (R(2) = 0.705), but the optimal correction factor for our cohort was 0.566.
  
  
  CONCLUSIONS
  In a Caucasian population, higher donor kidney volumes estimated from preoperative CT scans are associated with higher recipient eGFRs at 12 months after live-donor transplantation. Using this criterion, transplant teams can potentially improve selection of living donors if multiple donors are available. However, the need for precise estimation of donor kidney volumes should not be overlooked.
authors.affiliation: Urology Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal, josh_dias@hotmail.com.
authors.forename: Jorge
authors.initials: J
authors.lastname: Dias
authors.forename: Jorge
authors.initials: J
authors.lastname: Malheiro
authors.forename: Manuela
authors.initials: M
authors.lastname: Almeida
authors.forename: Leonídio
authors.initials: L
authors.lastname: Dias
authors.forename: Miguel
authors.initials: M
authors.lastname: Silva-Ramos
authors.forename: La Salete
authors.initials: LS
authors.lastname: Martins
authors.forename: Luís
authors.initials: L
authors.lastname: Xambre
authors.forename: António
authors.initials: A
authors.lastname: Castro-Henriques
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000502:physiology*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D055641:Mathematical Concepts; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D009927:Tissue and Organ Procurement / Q000592:standards*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
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