title: Association between birth weight and objectively measured sedentary time is mediated by central adiposity: data in 10,793 youth from the International Children's Accelerometry Database.
abstract: Birth weight is an early correlate of disease later in life, and animal studies suggest that low birth weight is associated with reduced activity and increased sedentary time. Whether birth weight predicts later sedentary time in humans is uncertain.
  
  
  
  We examined the relation between birth weight and sedentary time in youth and examined whether this association was mediated by central adiposity.
  
  
  
  We used pooled cross-sectional data from 8 observational studies conducted between 1997 and 2007 that consisted of 10,793 youth (boys: 47%) aged 6-18 y from the International Children's Accelerometry Database. Birth weight was measured in hospitals or maternally reported, sedentary time was assessed by using accelerometry (<100 counts/min), and abdominal adiposity (waist circumference) was measured according to WHO procedures. A mediation analysis with bootstrapping was used to analyze data.
  
  
  
  The mean (±SD) time spent sedentary was 370 ± 91 min/d. Birth weight was positively associated with sedentary time (B = 4.04, P = 0.006) and waist circumference (B = 1.59, P < 0.001), whereas waist circumference was positively associated with sedentary time (B = 0.82, P < 0.001). Results of the mediation analysis showed a significant indirect effect of birth weight on sedentary time through waist circumference (B: 1.30; 95% bias-corrected CI: 0.94, 1.72), and when waist circumference was controlled for, the effect of birth weight on sedentary time was attenuated by 32% (B = 2.74, P = 0.06).
  
  
  
  The association between birth weight and sedentary time appears partially mediated by central adiposity, suggesting that both birth weight and abdominal adiposity may be correlates of sedentary time in youth.
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Maria
authors.initials: M
authors.lastname: Hildebrand
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Elin
authors.initials: E
authors.lastname: Kolle
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Bjørge H
authors.initials: BH
authors.lastname: Hansen
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Collings
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Katrien
authors.initials: K
authors.lastname: Wijndaele
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kordas
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Ashley R
authors.initials: AR
authors.lastname: Cooper
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Sherar
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Lars Bo
authors.initials: LB
authors.lastname: Andersen
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Luis B
authors.initials: LB
authors.lastname: Sardinha
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Susi
authors.initials: S
authors.lastname: Kriemler
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Pedro
authors.initials: P
authors.lastname: Hallal
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Esther
authors.initials: E
authors.lastname: van Sluijs
authors.affiliation: From the Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway (MH, EK, BHH, LBA, and UE); the Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom (PJC, KW, EvS, and UE); the School of Social and Community Medicine (KK) and the Centre for Exercise, Nutrition & Health Sciences, School for Policy Studies (ARC), University of Bristol, Bristol, United Kingdom; the School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom (LB Sherar); the Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark (LBA); the Department of Sport and Health, University of Lisbon, Lisbon, Portugal (LB Sardinha); the Institute of Social and Preventive Medicine, University of Zürich, Zürich, Switzerland (SK); and the Department of Physical Education, Federal University of Pelotas, Pelotas, Brazil (PH).
authors.forename: Ulf
authors.initials: U
authors.lastname: Ekelund
mesh_terms: D061725:Accelerometry; D050154:Adiposity; D000293:Adolescent; D001724:Birth Weight; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D056128:Obesity, Abdominal / Q000453:epidemiology*; D064887:Observational Studies as Topic; D057185:Sedentary Behavior; D055105:Waist Circumference
keywords: abdominal adiposity; accelerometry; birth weight; mediation; sedentary time; youth
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