title: Brain imaging in cooled encephalopathic neonates does not differ between four and 11 days after birth.
abstract: OBJECTIVE
  The optimal timing of magnetic resonance imaging (MRI) in encephalopathic infants treated with hypothermia is unknown, and this study examined whether early scans differed from later scans.
  
  
  METHODS
  We assessed paired MRI scans carried out on 41 cooled encephalopathic infants at a median of four and 11 days using two scoring systems: the Rutherford injury scores for the basal ganglia and thalami (BGT), white matter and the posterior limb of the internal capsule, and the Bonifacio injury scores for the BGT and watershed area.
  
  
  RESULTS
  Both systems produced consistent injury severity scores in 37 of 41 infants on both days, with Rutherford scores predicting poor outcome in six early scans and seven later scans (K = 0.91) and Bonifacio doing the same in seven and nine scans (K = 0.85). A white matter/watershed score of two or a BGT score of one indicated severe changes by day 11 in three infants, but lower scores did not.
  
  
  CONCLUSIONS
  Magnetic resonance imaging scans indicated that the Rutherford and Bonifacio systems produced similar scores in 37 of 41 cooled encephalopathic infants at a median of four and 11 days. Infants with an early white matter/watershed scores of two or a BGT score of one may worsen and should be rescanned.
authors.affiliation: Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.|Department of Neonatal Intensive Care, Oslo University Hospital Ullevål, Oslo, Norway.
authors.forename: Janne Helen
authors.initials: JH
authors.lastname: Skranes
authors.affiliation: Neonatal Neuroscience, School of Medical Sciences, University of Bristol, Bristol, UK.
authors.forename: Frances Mary
authors.initials: FM
authors.lastname: Cowan
authors.affiliation: Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.|Department of Neonatal Intensive Care, Oslo University Hospital Ullevål, Oslo, Norway.
authors.forename: Tom
authors.initials: T
authors.lastname: Stiris
authors.affiliation: Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.|Department of Neonatal Intensive Care, Oslo University Hospital Ullevål, Oslo, Norway.
authors.forename: Drude
authors.initials: D
authors.lastname: Fugelseth
authors.affiliation: Neonatal Neuroscience, School of Medical Sciences, University of Bristol, Bristol, UK.|Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
authors.forename: Marianne
authors.initials: M
authors.lastname: Thoresen
authors.affiliation: Department of Neuroradiology, Oslo University Hospital, Oslo, Norway.
authors.forename: Andres
authors.initials: A
authors.lastname: Server
mesh_terms: D001921:Brain; D001927:Brain Diseases / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D011446:Prospective Studies; D013997:Time Factors
keywords: Bonifacio scores; Early cerebral magnetic resonance imaging; Hypothermia; Neonatal encephalopathy; Rutherford scores