title: Limonoids from the stem bark of Khaya senegalensis.
abstract: Six new limonoids with modified furan ring, khaysenelide A-F (1-6), together with six known limonoids (7-12) were isolated from the stem bark of Khaya senegalensis. The basic skeletons of these new limonoids belong to mexicanolide (1, 2) and rearrangement phragmalin (3-6), which were elucidated on the basis of spectroscopic methods including high resolution-electrospray ionization (HR-ESI)-MS, one and two dimensional (1D and 2D)-NMR and confirmed by single-crystal X-ray crystallography using CuKα radiation of 1 and 3. Their absolute configurations were determined by the X-ray crystallography data and comparison of their electronic circular dichroism spectra. The inhibitory effect on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages of new compounds was also tested.
authors.affiliation: Testing & Analysis Center, Nanjing Normal University; 2. State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry,  China Pharmaceutical University; 24  Tong Jia Xiang, Nanjing 210009, People’s Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Qinpei
authors.initials: Q
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Luo
authors.forename: Junsong
authors.initials: J
authors.lastname: Wang
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Wang
authors.forename: Mengdi
authors.initials: M
authors.lastname: Zhu
authors.forename: Lingyi
authors.initials: L
authors.lastname: Kong
mesh_terms: D000818:Animals; D002460:Cell Line; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D036701:Limonins; D008070:Lipopolysaccharides; D009569:Nitric Oxide