title: [Arterial hypertension: an expanding pathogenic continuum and therapeutic limitations].
abstract: The paper considers the role of the immune system, endoplasmic network stress, metabolic dysregulation, and epigenetic mechanisms in the pathogenesis of essential hypertension, as well as the limited possibilities of therapy with existing antihypertensive agents.
authors.affiliation: I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russia.
authors.forename: E P
authors.initials: EP
authors.lastname: Kharchenko
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D044127:Epigenesis, Genetic / Q000276:immunology; D006439:Hemodynamics / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000235:genetics / Q000276:immunology
chemical_list: D000959:Antihypertensive Agents; D007378:Interleukins