title: Fluorescent gold nanodots based sensor array for proteins discrimination.
abstract: A series of dual-ligand cofunctionalized fluorescent gold nanodots with similar fluorescence and diverse surface properties has been designed and synthesized to build a protein sensing array. Using this "chemical nose/tongue" strategy, fluorescence response patterns can be obtained on the array and identified via linear discriminant analysis (LDA). Eight proteins have been well distinguished at low concentration (A280 = 0.005) based on this sensor array. The practicability of this sensor array was further validated by high accuracy (100%) examination of 48 unknown protein samples.
authors.affiliation: †College of Chemistry and Chemical Engineering, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China.|‡Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Yuan
authors.affiliation: †College of Chemistry and Chemical Engineering, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China.|§Inspection and Testing Center for Agro-product Safety and Environment Quality, Institute of Applied Ecology Chinese Academy of Sciences (IAE CAS), 72 Wenhua Road, Shenyang, Liaoning 110016, P. R. China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Du
authors.affiliation: ‡Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Tseng
authors.affiliation: ∥Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, P. R. China.
authors.forename: Meihua
authors.initials: M
authors.lastname: Peng
authors.affiliation: †College of Chemistry and Chemical Engineering, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China.
authors.forename: Na
authors.initials: N
authors.lastname: Cai
authors.affiliation: †College of Chemistry and Chemical Engineering, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.affiliation: ‡Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei 10617, Taiwan.
authors.forename: Huan-Tsung
authors.initials: HT
authors.lastname: Chang
authors.affiliation: †College of Chemistry and Chemical Engineering, College of Biology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan 410082, P. R. China.
authors.forename: Edward S
authors.initials: ES
authors.lastname: Yeung
mesh_terms: D016002:Discriminant Analysis; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008163:Luminescent Measurements; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D011506:Proteins / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D011506:Proteins; D006046:Gold