title: Comprehensive assessment for novel prostate cancer markers in the prostate-specific antigen era: focusing on Asians and Asian countries.
abstract: We reviewed the current evidence for three novel prostate tumor markers (PCA3, TMPRSS2:ERG and proPSA) that have been recently reported predominantly in Western countries. We focus our attention on Asian men in both clinical and basic research studies. There have been no reports on the clinical usefulness of these three markers for Asians living in Western countries. In Asian countries, evidence for the clinical usefulness of PCA3 and proPSA-related indices including Prostate Health Index is being accumulated, mainly in Japan. The process for how a novel marker is approved in the clinical setting is also discussed.
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Okihara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ochiai
authors.forename: Kazumi
authors.initials: K
authors.lastname: Kamoi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Fujizuka
authors.forename: Tsuneharu
authors.initials: T
authors.lastname: Miki
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ito
mesh_terms: D000951:Antigens, Neoplasm / Q000652:urine*; D001208:Asia; D044466:Asian People; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine*; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000652:urine*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000652:urine; D011498:Protein Precursors / Q000097:blood*
chemical_list: C583834:(-2)pro-prostate-specific antigen, human; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; D011498:Protein Precursors; C515553:TMPRSS2-ERG fusion protein, human; C479341:prostate cancer antigen 3, human; D017430:Prostate-Specific Antigen
keywords: Asia; PCA3; TMPRSS2:ERG; proPSA; prostate cancer