title: Concomitant trimodality therapy of re-irradiation, chemotherapy and regional hyperthermia for a pretreated inoperable sarcoma recurrence.
abstract: We hereby present a case of pre-treated unresectable sarcoma recurrence of the trunk which showed an excellent response to concomitant tri-modal therapy, consisting of re-irradiation, chemotherapy and regional hyperthermia even with a strong compromised re-irradiation dose. No significant toxicity of the combined therapy and fast achievement of the pain and neurological symptoms relief are reported. The case shows that concurrent tri-modality treatment can be considered as a therapeutic option for the management of pre-treated unresectable recurrence even in there-irradiation setting.
authors.affiliation: Department of Radiation Oncology, University Hospital Munich, Munich - Germany.
authors.forename: Minglun
authors.initials: M
authors.lastname: LI
authors.forename: Claudia
authors.initials: C
authors.lastname: Andrä
authors.forename: Maximilian
authors.initials: M
authors.lastname: Niyazi
authors.forename: Rolf D
authors.initials: RD
authors.lastname: Issels
authors.forename: Sultan
authors.initials: S
authors.lastname: Abdel-Rahman
authors.forename: Feras
authors.initials: F
authors.lastname: Oskan
authors.forename: Farkhad
authors.initials: F
authors.lastname: Manapov
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000627:therapeutic use*; D001416:Back Pain / Q000209:etiology; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D059248:Chemoradiotherapy; D003937:Diagnosis, Differential; D019583:Dose Fractionation, Radiation; D004334:Drug Administration Schedule; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D009367:Neoplasm Staging; D017060:Patient Satisfaction; D011788:Quality of Life; D061089:Radiotherapy, Image-Guided; D019233:Retreatment; D013904:Thoracic Vertebrae; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide