title: Stochastic process for white matter injury detection in preterm neonates.
abstract: Preterm births are rising in Canada and worldwide. As clinicians strive to identify preterm neonates at greatest risk of significant developmental or motor problems, accurate predictive tools are required. Infants at highest risk will be able to receive early developmental interventions, and will also enable clinicians to implement and evaluate new methods to improve outcomes. While severe white matter injury (WMI) is associated with adverse developmental outcome, more subtle injuries are difficult to identify and the association with later impairments remains unknown. Thus, our goal was to develop an automated method for detection and visualization of brain abnormalities in MR images acquired in very preterm born neonates. We have developed a technique to detect WMI in T1-weighted images acquired in 177 very preterm born infants (24-32 weeks gestation). Our approach uses a stochastic process that estimates the likelihood of intensity variations in nearby pixels; with small variations being more likely than large variations. We first detect the boundaries between normal and injured regions of the white matter. Following this we use a measure of pixel similarity to identify WMI regions. Our algorithm is able to detect WMI in all of the images in the ground truth dataset with some false positives in situations where the white matter region is not segmented accurately.
authors.affiliation: Department of Computing Science, University of Alberta, Edmonton, AB T6G 2H1, Canada.
authors.forename: Irene
authors.initials: I
authors.lastname: Cheng
authors.affiliation: Hospital for Sick Children and the University of Toronto, Toronto, Canada.
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
authors.affiliation: Hospital for Sick Children and the University of Toronto, Toronto, Canada.
authors.forename: Emma G
authors.initials: EG
authors.lastname: Duerden
authors.affiliation: Department of Computing Science, University of Alberta, Edmonton, AB T6G 2H1, Canada.
authors.forename: Kaiyu
authors.initials: K
authors.lastname: Sun
authors.affiliation: Hospital for Sick Children and the University of Toronto, Toronto, Canada.
authors.forename: Vann
authors.initials: V
authors.lastname: Chau
authors.affiliation: Hospital for Sick Children and the University of Toronto, Toronto, Canada.
authors.forename: Elysia
authors.initials: E
authors.lastname: Adams
authors.affiliation: BC Children's Hospital and the University of British Columbia, Vancouver, Canada.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Poskitt
authors.affiliation: Hospital for Sick Children and the University of Toronto, Toronto, Canada.
authors.forename: Helen M
authors.initials: HM
authors.lastname: Branson
authors.affiliation: Department of Computing Science, University of Alberta, Edmonton, AB T6G 2H1, Canada.
authors.forename: Anup
authors.initials: A
authors.lastname: Basu
mesh_terms: D000465:Algorithms; D001930:Brain Injuries / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D066127:White Matter / Q000473:pathology*
keywords: Preterm neonates; Stochastic process; White matter injury
references.citation: Arch Dis Child. 2010 Oct;95(10):786-90
references.pmid: 19828882
references.citation: Arch Dis Child Fetal Neonatal Ed. 2005 Sep;90(5):F380-7
references.pmid: 16113154
references.citation: IEEE Trans Biomed Eng. 2009 Mar;56(3):781-9
references.pmid: 19174335
references.citation: Pediatr Res. 2012 Mar;71(3):274-9
references.pmid: 22278180
references.citation: J Pediatr. 2004 Nov;145(5):593-9
references.pmid: 15520756
references.citation: Arch Pediatr Adolesc Med. 2002 Jun;156(6):615-20
references.pmid: 12038896
references.citation: Pediatrics. 2006 May;117(5):1626-31
references.pmid: 16651316
references.citation: Neuroimage Clin. 2014;6:166-70
references.pmid: 25379428
references.citation: Neuroimage. 2013 Nov 15;82:77-86
references.pmid: 23721722
references.citation: Dev Med Child Neurol. 2013 Jun;55(6):509-19
references.pmid: 23346889
references.citation: PLoS One. 2012;7(4):e34858
references.pmid: 22532832
references.citation: IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
references.pmid: 11293691
references.citation: Neuropediatrics. 1993 Oct;24(5):263-8
references.pmid: 8309515
references.citation: Pediatrics. 2004 Dec;114(6):e725-32
references.pmid: 15576337
references.citation: Arch Dis Child Fetal Neonatal Ed. 2003 Jul;88(4):F275-9
references.pmid: 12819157
references.citation: Ann Neurol. 2009 Aug;66(2):155-64
references.pmid: 19743455
references.citation: Pediatrics. 2008 Nov;122(5):e1014-21
references.pmid: 18977951
references.citation: Br J Disord Commun. 1990 Aug;25(2):173-82
references.pmid: 2206965
references.citation: J Pediatr. 2015 Jan;166(1):39-43
references.pmid: 25311709
references.citation: J Pediatr. 2009 Jun;154(6):829-34.e1
references.pmid: 19230899
references.citation: J Magn Reson Imaging. 2002 Dec;16(6):621-32
references.pmid: 12451575
references.citation: Med Image Comput Comput Assist Interv. 2011;14(Pt 2):90-7
references.pmid: 21995017
references.citation: Brain. 2008 Dec;131(Pt 12):3201-8
references.pmid: 18952670
references.citation: Neuroimage Clin. 2015;7:170-6
references.pmid: 25610778
references.citation: Neuroimage Clin. 2013 Sep 30;3:369-80
references.pmid: 24273720
references.citation: PLoS One. 2012;7(12):e51879
references.pmid: 23284800
references.citation: J Pediatr. 2010 Jun;156(6):882-8, 888.e1
references.pmid: 20227731
references.citation: N Engl J Med. 2002 Jan 17;346(3):149-57
references.pmid: 11796848
references.citation: Neuroimage Clin. 2013 Aug 02;3:106-14
references.pmid: 24179854
references.citation: J Pediatr. 2005 Nov;147(5):609-16
references.pmid: 16291350
references.citation: Cerebellum. 2009 Sep;8(3):211-21
references.pmid: 19495901
references.citation: Neuroimage. 2011 Feb 14;54(4):2563-70
references.pmid: 21073965
references.citation: N Engl J Med. 2006 Aug 17;355(7):685-94
references.pmid: 16914704
references.citation: Pediatrics. 2009 Feb;123(2):503-11
references.pmid: 19171615
references.citation: Pediatrics. 2003 Oct;112(4):943-50
references.pmid: 14523190
references.citation: Pediatrics. 2007 Jul;120(1):70-7
references.pmid: 17606563
references.citation: Neurology. 2013 Dec 10;81(24):2082-9
references.pmid: 24212394
references.citation: Neuroimage Clin. 2012 Nov 16;2:79-94
references.pmid: 24179761
references.citation: J Pediatr. 2010 Apr;156(4):556-61.e1
references.pmid: 20138299
references.citation: J Pediatr. 2008 Apr;152(4):513-20, 520.e1
references.pmid: 18346506
references.citation: Ann Neurol. 2014 Apr;75(4):469-86
references.pmid: 24615937
references.citation: Neuroimage Clin. 2015;7:82-6
references.pmid: 25610769
references.citation: Neuroimage Clin. 2014;4:695-700
references.pmid: 24936407
references.citation: Pediatrics. 2007 Sep;120(3):e604-9
references.pmid: 17698966
references.citation: Pediatrics. 2007 Apr;119(4):759-65
references.pmid: 17403847
references.citation: J Pediatr. 2003 Aug;143(2):171-9
references.pmid: 12970628