title: Effects of liquid konjac on parameters related to obesity in diet-induced obese mice.
abstract: Konjac-mannan has been suggested to exert a protective effect against visceral obesity. However, there is little knowledge about the effects of liquid konjac (LK) that is partially alkali gelled. The purpose of the present work was to evaluate the potential beneficial effects of a LK powder on obesity in mice. Male C57BL/6J mice were fed a high-fat diet supplemented with either 2.5 or 5% LK powder for 80 days. Growth parameters, abdominal fat content, serum biochemical markers, and hepatic lipid accumulations were measured. Dietary supplementation with LK resulted in decreased body weight gain and abdominal fat accumulation. Dose-dependent decreases were observed in accumulation of hepatic lipids and serum total cholesterol, leptin, insulin concentrations. The study findings indicated that LK had preventing effect against obesity, including the reduction of abdominal and hepatic lipid accumulation and serum parameters related to obesity.
authors.affiliation: a Faculty of Home Economics, Department of Food Science , Otsuma Women's University , Tokyo , Japan.
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Aoe
authors.forename: Haruka
authors.initials: H
authors.lastname: Kudo
authors.forename: Seiya
authors.initials: S
authors.lastname: Sakurai
mesh_terms: D050153:Abdominal Fat / Q000187:drug effects; D017667:Adipocytes / Q000187:drug effects; D031056:Amorphophallus / Q000737:chemistry*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005243:Feces; D006863:Hydrogen-Ion Concentration; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000494:pharmacology; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000178:diet therapy* / Q000209:etiology; D009929:Organ Size / Q000187:drug effects
chemical_list: D008351:Mannans; C022901:(1-6)-alpha-glucomannan
keywords: abdominal fat; glucomannan; liquid konjac; obesity