title: Non-alcoholic fatty liver disease: when to intervene and with what.
abstract: Non-alcoholic fatty liver disease (NAFLD) is increasingly common due to the rising prevalence of obesity in both children and adults. It is associated with metabolic risk factors such as diabetes mellitus, dyslipidaemia and hypertension, and is associated with increased mortality both from cardiovascular-related and liver-related deaths. Identification of those individuals with significant inflammation and fibrosis is a critical part of the patient pathway. Current treatments for NAFLD include weight loss from lifestyle modification or bariatric surgery, management of underlying metabolic risk factors and for those with end stage liver disease, liver transplantation.
authors.affiliation: NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, and Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK;
authors.forename: Nwe Ni
authors.initials: NN
authors.lastname: Than
authors.affiliation: NIHR Centre for Liver Research and Biomedical Research Unit, University of Birmingham, and Liver Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK p.n.newsome@bham.ac.uk.
authors.forename: Philip N
authors.initials: PN
authors.lastname: Newsome
mesh_terms: D050110:Bariatric Surgery; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000628:therapy*; D012307:Risk Factors; D015431:Weight Loss
keywords: Non-alcoholic fatty liver disease; cirrhosis; insulin resistance; obesity; treatment
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