title: [Influence of delta-sleep inducing peptide on the state of lysosomal membranes and intensity of lysosomal proteolysis in different rat tissues during physiological aging of the organism].
abstract: It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the state of lysosomal membranes in rat tissues (brain, heart muscle and liver) at different ontogenetic stages, and this effect is accompanied by increasing intensity of lysosomal proteolysis in these tissues.
authors.forename: D S
authors.initials: DS
authors.lastname: Kutilin
authors.forename: T I
authors.initials: TI
authors.lastname: Bondarenko
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage* / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects* / Q000378:metabolism; D008062:Lipofuscin / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D010447:Peptide Hydrolases / Q000378:metabolism*; D059748:Proteolysis / Q000187:drug effects*; D051381:Rats
chemical_list: D008062:Lipofuscin; D003701:Delta Sleep-Inducing Peptide; D010447:Peptide Hydrolases