title: Mitigating risk in academic preclinical drug discovery.
abstract: The number of academic drug discovery centres has grown considerably in recent years, providing new opportunities to couple the curiosity-driven research culture in academia with rigorous preclinical drug discovery practices used in industry. To fully realize the potential of these opportunities, it is important that academic researchers understand the risks inherent in preclinical drug discovery, and that translational research programmes are effectively organized and supported at an institutional level. In this article, we discuss strategies to mitigate risks in several key aspects of preclinical drug discovery at academic drug discovery centres, including organization, target selection, assay design, medicinal chemistry and preclinical pharmacology.
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Jayme L
authors.initials: JL
authors.lastname: Dahlin
authors.affiliation: 1] National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, USA. [2] National Human Genome Research Institute, Bethesda, Maryland, 20892, USA.
authors.forename: James
authors.initials: J
authors.lastname: Inglese
authors.affiliation: Institute for Therapeutics Discovery and Development, University of Minnesota Twin Cities, 717 Delaware St SE, Room 609, Minneapolis, Minnesota 55414, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Walters
mesh_terms: D000046:Academic Medical Centers / Q000191:economics / Q000592:standards / Q000639:trends*; D000818:Animals; D003299:Cooperative Behavior; D055808:Drug Discovery / Q000191:economics / Q000592:standards / Q000639:trends*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009316:National Institutes of Health (U.S.); D012306:Risk; D054852:Small Molecule Libraries; D057170:Translational Research, Biomedical / Q000592:standards / Q000639:trends; D014481:United States
chemical_list: D054852:Small Molecule Libraries
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