title: Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus.
abstract: The goal of the present study was to evaluate the acaricidal potential of Lippia alba essential oil, citral chemotypes (LA-10 and LA-44 genotypes) and carvone chemotypes (LA-13 and LA-57 genotypes), as well as purified citral and enantiomers of carvone and limonene. Efficacy against Rhipicephalus microplus was assessed by the larval packet and the engorged female immersion tests. Citral chemotypes had greater larvicidal activity than carvone chemotypes, and this was further supported by larvicidal and adulticidal activity of purified citral with LC50 values of 7.0 and 29.8 mg/mL, respectively. While purified enantiomers of carvone exhibited greater larvicidal activity than those of limonene, enantioselectivity of limonene was observed with R-(+) displaying significantly higher efficacy (LC50 of 31.2mg/mL) than S-(-) (LC50 of 54.5mg/mL). The essential oils and purified compounds were much less toxic toward engorged adult females, with the exception of citral, and this may be due to limited cuticular penetration.
authors.affiliation: Agronomy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Magna Galvão
authors.initials: MG
authors.lastname: Peixoto
authors.affiliation: Animal Science Department, Federal University of Maranhão, Rua São José de Ribamar, n° 15, Boa Vista, CEP 65500-000 Chapadinha, MA, Brazil.
authors.forename: Livio Martins
authors.initials: LM
authors.lastname: Costa-Júnior
authors.affiliation: Agronomy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Arie Fitzgerald
authors.initials: AF
authors.lastname: Blank
authors.affiliation: Animal Science Department, Federal University of Maranhão, Rua São José de Ribamar, n° 15, Boa Vista, CEP 65500-000 Chapadinha, MA, Brazil.
authors.forename: Aldilene da Silva
authors.initials: Ada S
authors.lastname: Lima
authors.affiliation: Agronomy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Thays Saynara Alves
authors.initials: TS
authors.lastname: Menezes
authors.affiliation: Chemistry Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Darlisson de Alexandria
authors.initials: Dde A
authors.lastname: Santos
authors.affiliation: Chemistry Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Péricles Barreto
authors.initials: PB
authors.lastname: Alves
authors.affiliation: Pharmacy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Sócrates Cabral de Holanda
authors.initials: SC
authors.lastname: Cavalcanti
authors.affiliation: Agronomy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Leandro
authors.initials: L
authors.lastname: Bacci
authors.affiliation: Agronomy Department, Federal University of Sergipe, Av. Marechal Rondon S/N, CEP 49100-000 São Cristóvão, SE, Brazil. Electronic address: fatima.blank@gmail.com.
authors.forename: Maria de Fátima
authors.initials: Mde F
authors.lastname: Arrigoni-Blank
mesh_terms: D056810:Acaricides / Q000737:chemistry / Q000494:pharmacology*; D000080462:Acyclic Monoterpenes; D000818:Animals; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005838:Genotype; D000077222:Limonene; D032411:Lippia / Q000737:chemistry* / Q000235:genetics; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D048494:Rhipicephalus / Q000187:drug effects*; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D056810:Acaricides; D000080462:Acyclic Monoterpenes; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010938:Plant Oils; D013729:Terpenes; C006923:carvone; D000077222:Limonene; C007076:citral
keywords: Carvone; Cattle tick; Citral; Lippia alba; Volatile oil