title: Effect of salt intake and potassium supplementation on urinary renalase and serum dopamine levels in Chinese adults.
abstract: OBJECTIVE
  The aim of our study was to assess the effects of altered salt and potassium intake on urinary renalase and serum dopamine levels in humans.
  
  
  METHODS
  Forty-two subjects (28–65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for an additional 7 days (18.0 g/day of NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day of NaCl + 4.5 g/day of KCl).
  
  
  RESULTS
  Urinary renalase excretions were significantly higher during the high-salt diet intervention than during the low-salt diet. During high-potassium intake, urinary renalase excretions were not significantly different from the high-salt diet, whereas they were significantly higher than the low-salt levels. Serum dopamine levels exhibited similar trends across the interventions. Additionally, a significant positive relationship was observed between the urine renalase and serum dopamine among the different dietary interventions. Also, 24-hour urinary sodium excretion positively correlated with urine renalase and serum dopamine in the whole population.
  
  
  CONCLUSIONS
  The present study indicates that dietary salt intake and potassium supplementation increase urinary renalase and serum dopamine levels in Chinese subjects.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Mu
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Liu
authors.forename: Bing-Qing
authors.initials: BQ
authors.lastname: Xie
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Dong
authors.forename: Zu-Yi
authors.initials: ZY
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology*; D002681:China; D004298:Dopamine / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000652:urine*; D011188:Potassium / Q000008:administration & dosage*; D011446:Prospective Studies; D012424:Rural Population; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage* / Q000652:urine
chemical_list: D017673:Sodium Chloride, Dietary; D008995:Monoamine Oxidase; C521557:renalase; D011188:Potassium; D004298:Dopamine