title: Methods of myofibrillogenesis modeling.
abstract: Organization in the heart is important on multiple length scales. Myofibrillogenesis processes control the assembly of this multi-scale architecture. Understanding myofibrillogenesis might allow us to better control self-assembly of cardiac tissues. One approach consists of creating phenomenological models and comparing these models to in vitro data from primary myocytes. In this chapter, we present a method for building these models to recapitulate different aspects of myofibrillogenesis. We present a specific example for a cardiomyocyte model, but the same procedure can be used to model fibrillogenesis with other mechanisms such as motility. In sum, the models allow for a better understanding of mechanisms behind self-assembly.
authors.affiliation: University of California, Irvine, Irvine, CA, USA.
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Drew
authors.forename: Anna
authors.initials: A
authors.lastname: Grosberg
mesh_terms: D000465:Algorithms; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D005455:Fluorescent Antibody Technique; D008955:Models, Cardiovascular; D024510:Muscle Development / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000502:physiology; D009210:Myofibrils / Q000502:physiology; D061251:Primary Cell Culture / Q000379:methods; D051381:Rats; D015203:Reproducibility of Results