title: Reprint of "The mitochondrial permeability transition pore and its adaptive responses in tumor cells".
abstract: This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) – a key effector in the mitochondrial pathways to cell death – and on the adaptive responses of tumor cells that desensitize the PTP to Ca(2+) and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F-ATP synthase; and the definition of the Ca(2+)- and ROS-dependent signaling pathways affecting the transition of the F-ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells.
authors.affiliation: Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address: rasola@bio.unipd.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Rasola
authors.affiliation: Department of Biomedical Sciences and CNR Neuroscience Institute, University of Padova, Italy. Electronic address: bernardi@bio.unipd.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernardi
keywords: Cancer; F-ATP synthase; Mitochondria; Permeability transition; Reactive oxygen species