title: Association between N-terminal pro B-type natriuretic peptide and day-to-day blood pressure and heart rate variability in a general population: the Ohasama study.
abstract: BACKGROUND
  In addition to day-to-day variability in blood pressure (BP) or heart rate (HR), N-terminal pro B-type natriuretic peptide (NT-proBNP) has been reported to be a predictor of cardiovascular disease. Here, we tested the hypothesis that day-to-day BP or HR variability calculated as the intraindividual standard deviation (SD) of home BP or HR is associated with elevated NT-proBNP in a cross-sectional study.
  
  
  METHODS
  Among 664 participants (mean age, 61.9 years; female, 70.5%) from a general Japanese population without a history of heart disease, 86 (13.0%) had NT-proBNP at least 125 pg/ml.
  
  
  RESULTS
  Each 1 SD increase in the SD of home systolic BP (SBP) [odds ratio (OR), 1.82; P < .0001) and in the SD of home HR (OR, 1.44; P = 0.008) were significantly associated with the prevalence of NT-proBNP at least 125 pg/ml after adjustment for possible confounding factors including home SBP and HR. Among the four groups defined by the median SD of home SBP and of home HR, the group with higher SDs in home SBP (≥8.0 mmHg) and HR (≥5.0 bpm) had the greatest OR for the prevalence of NT-proBNP at least 125 pg/ml (OR, 4.80; P = 0007 vs. a reference group with lower SDs of home SBP and HR).
  
  
  CONCLUSIONS
  These results suggest that day-to-day variability in BP and HR may be associated with target-organ damage or complications, which can lead to an elevated NT-proBNP level. An elevated NT-proBNP level may be involved in the prognostic significance of day-to-day variability in BP or HR.
authors.affiliation: aDepartment of Pharmacy, Tohoku University Hospital bDepartment of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai cDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo dTohoku Medical Megabank Organization, Tohoku University eDepartment of Medical Information Technology Center, Tohoku University Hospital, Sendai fNational Institute of Health and Nutrition, Tokyo, Japan gResearch Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, Studies Coordinating Centre, University of Leuven, Leuven, Belgium hEarly Development and Pathologies, Center for Interdisciplinary Research in Biology, College de France, Paris, France iFaculty of Synthetic Welfare, Department of Social Welfare, the Tohoku Fukushi University, Sendai jDepartment of Internal Medicine, Ohasama Hospital, Iwate kDepartment of Cardiovascular Medicine, Saga University, Saga, Japan.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Satoh
authors.forename: Miki
authors.initials: M
authors.lastname: Hosaka
authors.forename: Kei
authors.initials: K
authors.lastname: Asayama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuya
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Inoue
authors.forename: Hirohito
authors.initials: H
authors.lastname: Metoki
authors.forename: Megumi
authors.initials: M
authors.lastname: Tsubota-Utsugi
authors.forename: Azusa
authors.initials: A
authors.lastname: Hara
authors.forename: Takuo
authors.initials: T
authors.lastname: Hirose
authors.forename: Taku
authors.initials: T
authors.lastname: Obara
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Totsune
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Hoshi
authors.forename: Nariyasu
authors.initials: N
authors.lastname: Mano
authors.forename: Koichi
authors.initials: K
authors.lastname: Node
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Imai
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohkubo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010507:Periodicity
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain