title: Shape-controlled ceria-reduced graphene oxide nanocomposites toward high-sensitive in situ detection of nitric oxide.
abstract: Nitric oxide (NO) is an important signal molecule released by most cancer cells under drug stimulation or/and disease development but it is extremely challenging to in situ while real-time sensitively detect NO due to its large diffusivity, low concentration and fast decay. Herein, shape-controlled reduced graphene oxide nanocomposing with ceria (rGO-CeO2) was synthesized via hydrothermal reaction to construct a highly sensitive real-time sensing platform for NO detection. The crystal shape of CeO2 nanoparticles in rGO-CeO2 composites significantly affects the sensing performance of rGO-CeO2, of which the regular hexagonal nanocrystal CeO2 achieves the highest sensitivity (1676.06 mA cm(-2) M(-1)), a wide dynamic range (18.0 nM to 5.6 µM) and a low detection limit (9.6 nM). This attributes to a synergical effect from high catalytic activity of the specifically shaped CeO2 nanocrystal and good conductivity/high surface area of rGO. This work demonstrates a way by rationally compose individual merit components while well control the nanostructure for a superior synergistic effect to build a smart sensing platform, while offering a great application potential to sensitively real-time detect NO released from living cells for diagnosis or/and studies of complicated biological processes.
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China; Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China.
authors.forename: Fang Xin
authors.initials: FX
authors.lastname: Hu
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China; Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China.
authors.forename: Jia Le
authors.initials: JL
authors.lastname: Xie
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China; Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China.
authors.forename: Shu Juan
authors.initials: SJ
authors.lastname: Bao
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China; Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yu
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Chongqing 400715, China; Faculty of Materials and Energy, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing 400715, China. Electronic address: ecmli@swu.edu.cn.
authors.forename: Chang Ming
authors.initials: CM
authors.lastname: Li
mesh_terms: D001681:Biological Assay / Q000295:instrumentation; D045744:Cell Line, Tumor; D002563:Cerium / Q000737:chemistry*; D003217:Conductometry / Q000295:instrumentation*; D003460:Crystallization / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008839:Microelectrodes; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010087:Oxides; D002563:Cerium; D009569:Nitric Oxide; C030583:ceric oxide; D006108:Graphite
keywords: Ceria-reduced graphene oxide nanocomposites; Electrochemical sensor; Nitric oxide; Real-time living cell detection