title: Comparison of etomidate and propofol on intubating conditions and the onset time associated with cisatracurium administration.
abstract: BACKGROUND
  This study compared intubating conditions and the onset time associated with administration of cisatracurium, a nondepolarizing neuromuscular blocker with a relatively slow onset, according to prior injection of one of two intravenous anesthetic agents: propofol or etomidate.
  
  
  METHODS
  Forty-six female patients, undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to two groups; group P were administered propofol (2 mg/kg) prior to cisatracurium (0.2 mg/kg); group E were administered etomidate (0.3 mg/kg) prior to cisatracurium (0.2 mg/kg). We measured intubating conditions and the onset time according to the types of intravenous anesthetic administered. Measurements of heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were taken immediately prior to induction; immediately and 1 min after IV anesthetic administration; and immediately and 1, 2, 3, 4, 5, 7, and 15 min after endotracheal intubation.
  
  
  RESULTS
  Intubating conditions were superior in group E compared with group P (P = 0.009). The average onset time of cisatracurium was more rapid in group E (155.74 ± 32.92 s vs. 185.26 ± 38.57 s in group P; P = 0.008). There were no group differences in SBP, DBP, and HR following intravenous anesthetic drug injection and endotracheal intubation. However, SBP and DBP were substantially higher in group E after endotracheal intubation.
  
  
  CONCLUSIONS
  Etomidate improves intubating conditions and provide a more rapid onset time of cisatracurium during anesthetic induction compared to propofol.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Young-Kwon
authors.initials: YK
authors.lastname: Ko
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Yoon-Hee
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Sang-Il
authors.initials: SI
authors.lastname: Park
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Woo Suk
authors.initials: WS
authors.lastname: Chung
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Chan
authors.initials: C
authors.lastname: Noh
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chungnam National University College of Medicine, Daejeon, Korea.
authors.forename: Jung-Un
authors.initials: JU
authors.lastname: Lee
keywords: Cisatracurium; Etomidate; Intratracheal intubation; Neuromuscular blockade; Propofol
references.citation: Can J Anaesth. 2003 Feb;50(2):108-15
references.pmid: 12560298
references.citation: Acta Anaesthesiol Scand. 2004 May;48(5):577-81
references.pmid: 15101851
references.citation: Br J Anaesth. 1992 Sep;69(3):269-73
references.pmid: 1389845
references.citation: Anesthesiology. 1999 Jul;91(1):58-70
references.pmid: 10422929
references.citation: Korean J Anesthesiol. 2013 Jan;64(1):34-9
references.pmid: 23372884
references.citation: Anesth Analg. 1989 Jul;69(1):35-40
references.pmid: 2787130
references.citation: Clin Pharmacol Ther. 1995 Aug;58(2):132-42
references.pmid: 7648763
references.citation: J Clin Anesth. 2010 Sep;22(6):425-31
references.pmid: 20868963
references.citation: Br J Anaesth. 1998 Apr;80(4):504-6
references.pmid: 9640158
references.citation: Br J Anaesth. 1999 Sep;83(3):483-4
references.pmid: 10655927
references.citation: Anesth Analg. 2003 Apr;96(4):1042-6, table of contents
references.pmid: 12651656
references.citation: Can J Anaesth. 2010 Feb;57(2):113-9
references.pmid: 19908105
references.citation: Anaesthesia. 1988 Aug;43(8):638-40
references.pmid: 3262318
references.citation: Br J Anaesth. 1992 Nov;69(5):444-6
references.pmid: 1467072
references.citation: Anesth Analg. 1997 Mar;84(3):623-8
references.pmid: 9052314
references.citation: Can J Anaesth. 2003 Feb;50(2):121-6
references.pmid: 12560300