title: Effects of diet quality on vulnerability to mild subchronic social defeat stress in mice.
abstract: OBJECTIVE
  The chronic social defeat stress (CSDS) mouse model is a potentially useful system for understanding stress responses to social environments. We previously developed a mouse model of subchronic and mild social defeat stress (sCSDS) that exhibits increased body weight gain and food intake following polydipsia-like features. sCSDS mice also show avoidance behavior in a social interaction test. In this study, we examined the effects of diet quality on susceptibility to sCSDS by feeding these mice semi- and non-purified diets.
  
  
  METHODS
  Male C57BL/6J (B6; n = 82) mice were exposed to sCSDS using male ICR mice. The B6 mice were divided into four test groups: semi-purified pellet diet + sCSDS, non-purified pellet diet + sCSDS, semi-purified diet + control (no sCSDS), and non-purified diet + control.
  
  
  RESULTS
  Although increased body weight, and food and water intake following sCSDS exposure were consistently observed in the groups that were fed semi- and non-purified diets, social avoidance behavior was influenced by food type (i.e., sCSDS mice fed semi-purified diet showed the greatest social avoidance behavior). In addition, the rates of stress susceptibility were estimated at 73.9 and 34.8% in sCSDS mice fed semi-purified and non-purified diets, respectively (P < 0.05). For comparison, the susceptible-like phenotype rates were estimated at 12.5 and 8.3% in healthy control mice fed semi-purified and non-purified diets, respectively.
  
  
  CONCLUSIONS
  These results suggest that diet quality affects the vulnerability of mice to social defeat stress.
authors.affiliation: a College of Agriculture , Ibaraki University , Ami, Ibaraki 300-0393 , Japan.|b Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) , Ami, Ibaraki 300-0393 , Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Goto
authors.affiliation: a College of Agriculture , Ibaraki University , Ami, Ibaraki 300-0393 , Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kubota
authors.affiliation: a College of Agriculture , Ibaraki University , Ami, Ibaraki 300-0393 , Japan.|b Ibaraki University Cooperation between Agriculture and Medical Science (IUCAM) , Ami, Ibaraki 300-0393 , Japan.|c United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology , Fuchu-city , Tokyo 183-8509 , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyoda
mesh_terms: D000374:Aggression / Q000523:psychology; D000818:Animals; D001522:Behavior, Animal; D004032:Diet / Q000009:adverse effects*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D002149:Energy Intake; D063427:Food Quality; D005526:Food, Formulated / Q000009:adverse effects; D006963:Hyperphagia / Q000209:etiology* / Q000523:psychology; D008297:Male; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D059607:Polydipsia, Psychogenic / Q000209:etiology* / Q000523:psychology; D012919:Social Behavior; D012930:Social Dominance; D012934:Social Isolation / Q000523:psychology; D013312:Stress, Physiological; D013315:Stress, Psychological / Q000209:etiology* / Q000503:physiopathology; D015430:Weight Gain
keywords: Diet; Mouse; Psychological stress; Resilience; Social behavior; Susceptible; Vulnerability