title: The association of XRCC3 Thr241Met genetic variant with risk of prostate cancer: a meta-analysis.
abstract: BACKGROUND
  Previous studies suggest that the X-ray repair cross-complementing group 3 gene (XRCC3) Thr241Met genetic variant could be potentially associated with the risk of prostate cancer. However, results from these published studies were conflicting rather than conclusive.
  
  
  OBJECTIVE
  his meta-analysis aimed to conduct a better understanding of the effects of XRCC3 Thr241Met genetic variant on prostate cancer risk.
  
  
  METHODS
  We identified three eligible studies, 499 prostate cancer cases and 571 controls.
  
  
  RESULTS
  Overall, significant associations were detected in the heterozygote comparison genetic model (CT versus (vs.) CC: OR = 0.71, 95% CI 0.53-0.94, Z =2.38, p= 0.017), and the dominant genetic model (TT/CT vs. CC: OR = 0.74, 95% CI 0.57-0.98, Z = 2.11, p =0.035). In the subgroup analysis by ethnicities, we found that this genetic variant was significantly associated with the decrease risk of prostate cancer in Caucasians for heterozygote comparison genetic model (CT vs. CC: OR = 0.66, 95% CI 0.44-0.98, Z = 2.04, p = 0.042). No publication bias was found in this study.
  
  
  CONCLUSIONS
  Results from this meta-analysis indicate that the XRCC3 Thr241Met genetic variant is associated with prostate cancer risk.
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu 241000, Hubei Province, People's Republic of China.
authors.forename: Gao
authors.initials: G
authors.lastname: Xuan
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu 241000, Hubei Province, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Hui
authors.affiliation: College of Life Science, Anhui Normal University, Wuhu 241000, Hubei Province, People's Republic of China.
authors.forename: He
authors.initials: H
authors.lastname: Fang
mesh_terms: D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3
keywords: Genetic variant; Meta-analysis; Prostate cancer; XRCC3 gene
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