title: [Colonoscopy sedation: clinical trial comparing propofol and fentanyl with or without midazolam].
abstract: Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists. The aim of this study was to evaluate the side effects of sedation, discharge conditions, quality of sedation, and propofol consumption during colonoscopy, with or without midazolam as preanesthetic. The study involved 140 patients who underwent colonoscopy at the University Hospital of the Federal University of Juiz de Fora. Patients were divided into two groups: Group I received intravenous midazolam as preanesthetic five minutes before sedation, followed by fentanyl and propofol; Group II received intravenous anesthesia with fentanyl and propofol. Patients in Group II had a higher incidence of reaction (motor or verbal) to the colonoscope introduction, bradycardia, hypotension, and increased propofol consumption. Patient satisfaction was higher in Group I. According to the methodology used, the combination of midazolam, fentanyl, and propofol for colonoscopy sedation reduces propofol consumption and provides greater patient satisfaction.
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Jose Francisco Nunes Pereira das
authors.initials: JF
authors.lastname: Neves
authors.affiliation: Instituto Nacional de Traumatologia e Ortopedia (INTO), Rio de Janeiro, RJ, Brasil.
authors.forename: Mariana Moraes Pereira das Neves
authors.initials: MM
authors.lastname: Araújo
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Fernando de Paiva
authors.initials: Fde P
authors.lastname: Araújo
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Clarice Martins
authors.initials: CM
authors.lastname: Ferreira
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Fabiana Baeta Neves
authors.initials: FB
authors.lastname: Duarte
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Fabio Heleno
authors.initials: FH
authors.lastname: Pace
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil.
authors.forename: Laura Cotta
authors.initials: LC
authors.lastname: Ornellas
authors.affiliation: UNC School of Medicine, North Carolina, EUA.
authors.forename: Todd H
authors.initials: TH
authors.lastname: Baron
authors.affiliation: Universidade Federal de Juiz de Fora (UFJF), Juiz de Fora, MG, Brasil. Electronic address: lincoln.ferreira@ufjf.edu.br.
authors.forename: Lincoln Eduardo Villela Vieira de Castro
authors.initials: LE
authors.lastname: Ferreira
keywords: Colonoscopia; Colonoscopy; Fentanil; Midazolam; Propofol; Sedation; Sedação