title: Direct retrospective comparison of adalimumab and infliximab in preventing early postoperative endoscopic recurrence after ileocaecal resection for crohn's disease: results from the MULTIPER database.
abstract: OBJECTIVE
  Both adalimumab [ADA] and infliximab [IFX] seem to be effective in the prevention of early postoperative endoscopic recurrence [EPER] after ileocaecal resection in Crohn's disease [CD] patients. There is lack of data with direct comparison between the two agents in the postoperative scenario. The aim of this study was to compare the rates of EPER in patients treated with ADA and IFX after ileocaecal resection for CD.
  
  
  METHODS
  This was a multicentre retrospective analysis of EPER rates in CD patients after ileocaecal resections, from seven referral centres in three countries. Endoscopic recurrence was defined as Rutgeerts' score ≥ i2. The patients were allocated according to treatment to two groups: ADA or IFX. The EPER rates were compared between the two treatment groups.
  
  
  RESULTS
  Among the 168 patients included in the database, 96 received anti-tumour necrosis factor [TNF] agents after resection [37 in the ADA and 59 in the IFX groups] and were included in this comparative study. The groups were comparable in all baseline characteristics, mainly age, gender, previous resections, perianal CD, and mono or combination therapy. EPER was identified in 9/37 [24.32%] in the ADA group vs 16/59 [27.12%] in the IFX group [p = 0.815].
  
  
  CONCLUSIONS
  In this retrospective direct comparison between ADA and IFX therapy after ileocaecal resection, there was no significant difference between the two anti-TNF agents in terms of EPER rates. However, prospective randomised studies are needed to confirm these data and better define the role of each agent in the prevention of EPER.
authors.affiliation: Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, Brazil pgkotze@hotmail.com.
authors.forename: Paulo Gustavo
authors.initials: PG
authors.lastname: Kotze
authors.affiliation: IBD Centre, Yokkaichi Hazu Medical Centre, Yokkaichi, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: IBD Unit, Humanitas Research Hospital, Milano, Italy.
authors.forename: Silvio
authors.initials: S
authors.lastname: Danese
authors.affiliation: Gastroenterology Unit, Toho University Sakura Medical Centre, Chiba, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Colorectal Surgery, Gastrosaude, Marilia, Brazil.
authors.forename: Fabio Vieira
authors.initials: FV
authors.lastname: Teixeira
authors.affiliation: IBD Unit, Heliopolis Hospital, Sao Paulo, Brazil.
authors.forename: Idblan Carvalho
authors.initials: IC
authors.lastname: de Albuquerque
authors.affiliation: Digestive Surgery Department, Sao Paulo State University [UNESP], Botucatu, Brazil.
authors.forename: Rogerio
authors.initials: R
authors.lastname: Saad-Hossne
authors.affiliation: Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, Brazil.
authors.forename: Ivan Folchini
authors.initials: IF
authors.lastname: de Barcelos
authors.affiliation: Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, Brazil.
authors.forename: Rodolff Nunes
authors.initials: RN
authors.lastname: da Silva
authors.affiliation: Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, Brazil.
authors.forename: Lorete Maria
authors.initials: LM
authors.lastname: da Silva Kotze
authors.affiliation: Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Olandoski
authors.affiliation: Colorectal Surgery Unit, Humanitas Research Hospital, Milano, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Sacchi
authors.affiliation: Colorectal Surgery, Gastrosaude, Marilia, Brazil.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yamada
authors.affiliation: Colorectal Surgery, Gastrosaude, Marilia, Brazil.
authors.forename: Ken
authors.initials: K
authors.lastname: Takeuchi
authors.affiliation: Colorectal Surgery Unit, Humanitas Research Hospital, Milano, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Spinelli
mesh_terms: D000068879:Adalimumab / Q000627:therapeutic use*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002432:Cecum / Q000601:surgery; D003424:Crohn Disease / Q000473:pathology / Q000517:prevention & control* / Q000601:surgery; D016208:Databases, Factual; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D000069285:Infliximab / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab; D000068879:Adalimumab
keywords: Crohn’s disease; postoperative care; recurrence