title: 5-HT3 receptor antagonists for the treatment of nausea/vomiting.
abstract: It is well appreciated that a number of things (e.g., various insults, chemotherapeutic agents, radiation) may lead to the release of serotonin from the enterochromaffin of the gastrointestinal tract. Released serotonin may then bind to certain 5-HT3 receptors and promote nausea/vomiting. 5-HT3 receptor antagonists may ameliorate nausea/vomiting in a number of circumstances and have been utilized as important antiemetics for multiple conditions such as chemotherapy-induced nausea/vomiting (CINV), radiation-induced emesis (RIS), and postoperative nausea/vomiting (PONV).
authors.affiliation: Albany Medical College, Department of Anesthesiology, 47 New Scotland Avenue, MC-131, Albany, New York 12208, USA. smithh@mail.amc.edu.
authors.forename: Howard S
authors.initials: HS
authors.lastname: Smith
authors.affiliation: Palliative Medicine Service, Albany Medical Center Hospital, 47 New Scotland Avenue, Albany, New York 12208, USA.
authors.forename: Lorraine R
authors.initials: LR
authors.lastname: Cox
authors.affiliation: 36 Grantwood Road, Delmar, New York 12054, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Smith
keywords: 5-HT3 antagonists; Nausea/Vomiting; chemotherapy-induced nausea/vomiting; ondansetron; palonostron; postoperative nausea/vomiting; serotonin