title: Secreted frizzled-related protein 4 predicts progression of autosomal dominant polycystic kidney disease.
abstract: BACKGROUND
  Autosomal dominant polycystic kidney disease (ADPKD) is a common autosomal dominant condition associated with renal cysts and development of renal failure. With the availability of potential therapies, one major obstacle remains the lack of readily available parameters that identify patients at risk for disease progression and/or determine the efficacy of therapeutic interventions within short observation periods. Increased total kidney volume (TKV) correlates with disease progression, but it remains unknown how accurate this parameter can predict disease progression at early stages.
  
  
  METHODS
  To identify additional parameters that help to stratify ADPKD patients, we measured secreted frizzled-related protein 4 (sFRP4) serum concentrations at baseline and over the course of 18 months in 429 ADPKD patients.
  
  
  RESULTS
  Serum creatinine and sFRP4 as well as TKV increased over time, and were significantly different from baseline values within 1 year.
  
  
  CONCLUSIONS
  Elevated sFRP4 levels at baseline predicted a more rapid decline of renal function at 2, 3 and 5 years suggesting that sFRP4 serum levels may provide additional information to identify ADPKD patients at risk for rapid disease progression.
authors.affiliation: Renal Division, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Zschiedrich
authors.affiliation: Renal Division, Charité Universitätsmedizin Berlin - Campus Mitte, Berlin, Germany.
authors.forename: Klemens
authors.initials: K
authors.lastname: Budde
authors.affiliation: Department of Nephrology, Helios Kliniken Schwerin, Schwerin, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Nürnberger
authors.affiliation: Renal Division, University Hospital Würzburg, Würzburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Wanner
authors.affiliation: Center for Nephrology, University Hospital Heidelberg, Heidelberg, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sommerer
authors.affiliation: Renal Division, University Hospital Kiel, Kiel, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kunzendorf
authors.affiliation: Renal Division, University Hospital Regensburg, Regensburg, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Banas
authors.affiliation: Department of Internal Medicine III, University Hospital, Vienna, Germany.
authors.forename: Walter H
authors.initials: WH
authors.lastname: Hoerl
authors.affiliation: Renal Division, Center for Internal Medicine, University Hospital Frankfurt, Frankfurt, Germany.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Obermüller
authors.affiliation: Department of Nephrology, Merheim Medical Center, Cologne, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Arns
authors.affiliation: Renal Division, University Hospital Münster, Münster, Germany.
authors.forename: Hermann
authors.initials: H
authors.lastname: Pavenstädt
authors.affiliation: Renal Division, Charité Universitätsmedizin Berlin - Campus Mitte, Berlin, Germany.
authors.forename: Jens
authors.initials: J
authors.lastname: Gaedeke
authors.affiliation: Renal Division, University Hospital Leipzig, Leipzig, Germany.
authors.forename: Tom H
authors.initials: TH
authors.lastname: Lindner
authors.affiliation: Novartis Pharma GmbH, Nuremberg, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Faerber
authors.affiliation: Novartis Pharma GmbH, Nuremberg, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Wimmer
authors.affiliation: Thermo Fisher Scientific, Freiburg, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Stork
authors.affiliation: Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Kai-Uwe
authors.initials: KU
authors.lastname: Eckardt
authors.affiliation: Renal Division, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Walz
mesh_terms: D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D016891:Polycystic Kidney, Autosomal Dominant / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D011518:Proto-Oncogene Proteins / Q000097:blood*; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D011518:Proto-Oncogene Proteins; C118723:SFRP4 protein, human; D000094742:Secreted Frizzled-Related Proteins
keywords: ADPKD; biomarker; progression; sFRP4