title: Differences in Evolution of HIV-1 Subtype C Reverse Transcriptase Between Children and Adults Likely Explained by Maturity of Cytotoxic T-Lymphocyte Responses.
abstract: In this study HIV-1 subtype C-infected adults demonstrated higher purifying selection on their viral populations in reverse transcriptase (RT) than infected children. This difference is likely explained by more mature cytotoxic T-lymphocyte responses in adults, which may have implications for the development of drug resistance in the RT region.
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Shanmugam
authors.initials: S
authors.lastname: Saravanan
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Selvamurthi
authors.initials: S
authors.lastname: Gomathi
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Bagavathi
authors.initials: B
authors.lastname: Kausalya
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Jayaseelan
authors.initials: J
authors.lastname: Boobalan
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Kailapuri G
authors.initials: KG
authors.lastname: Murugavel
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Pachamuthu
authors.initials: P
authors.lastname: Balakrishnan
authors.affiliation: 2Asha Kirana Hospital, Mysore, India.
authors.forename: Sarvode N
authors.initials: SN
authors.lastname: Mothi
authors.affiliation: 1YRG CARE, Chennai, India.|3Johns Hopkins University, Baltimore, Maryland.
authors.forename: Sunil S
authors.initials: SS
authors.lastname: Solomon
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Nagalingeswaran
authors.initials: N
authors.lastname: Kumarasamy
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Poongulali
authors.initials: P
authors.lastname: Selvamuthu
authors.affiliation: 1YRG CARE, Chennai, India.
authors.forename: Suniti
authors.initials: S
authors.lastname: Solomon
authors.affiliation: 4University of California San Diego, La Jolla, California.|5Veterans Affairs Healthcare System, San Diego, California.
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
mesh_terms: D000328:Adult; D002648:Child; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D054303:HIV Reverse Transcriptase / Q000235:genetics*; D015497:HIV-1 / Q000145:classification / Q000201:enzymology* / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase
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