title: Irisin: A myokine with locomotor activity.
abstract: The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin significantly increased the locomotion. Relative to control animals treated with IgG Fc peptide, rats receiving irisin demonstrated a marked increase in total travel distance, ambulatory counts and time, and vertical counts and time. These changes were associated with a significant decrease in resting time. Central treatment of irisin also induced significant increases in oxygen consumption, carbon dioxide production and heat production, indicating an increase in metabolic activity. Our study suggests that physical activity may signal to the central nervous system to coordinate locomotion with metabolic activity via irisin.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing 100191, China. Electronic address: weizhenz@umich.edu.
authors.forename: Weizhen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: lincha@umich.edu.
authors.forename: Lin
authors.initials: L
authors.lastname: Chang
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ruthann
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Ziru
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Biaoxin
authors.initials: B
authors.lastname: Chai
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Jiyao
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Eugene
authors.initials: E
authors.lastname: Chen
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Mulholland
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D017207:Rats, Sprague-Dawley
chemical_list: C583676:FNDC5 protein, rat; D005353:Fibronectins; D002245:Carbon Dioxide
keywords: Central nervous system; Irisin; Locomotion; Metabolism
references.citation: Science. 2012 Apr 6;336(6077):42-3
references.pmid: 22491843
references.citation: Cell. 2012 Jul 20;150(2):366-76
references.pmid: 22796012
references.citation: J Diabetes. 2012 Sep;4(3):196
references.pmid: 22372821
references.citation: Neuroscience. 2013 Feb 12;231:296-304
references.pmid: 23219938
references.citation: Metabolism. 2013 Aug;62(8):1131-6
references.pmid: 23664146
references.citation: Nature. 2012 Jan 26;481(7382):463-8
references.pmid: 22237023
references.citation: Cell Metab. 2013 Nov 5;18(5):649-59
references.pmid: 24120943
references.citation: FEBS J. 2014 Feb;281(3):739-49
references.pmid: 24237962
references.citation: Peptides. 2014 Nov;61:130-6
references.pmid: 25261800
references.citation: J Appl Physiol (1985). 2011 Jan;110(1):264-74
references.pmid: 21030673
references.citation: Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1115-25
references.pmid: 21368268
references.citation: PLoS One. 2013;8(9):e73680
references.pmid: 24040023