title: Monounsaturated fatty acids-rich diets in hypercholesterolemic-growing rats.
abstract: The effects of replacing dietary saturated fat by different monounsaturated fatty acid (ω-9MUFA) sources on serum lipids, body fat and bone in growing hypercholesterolemic rats were studied. Rats received one of the six different diets: AIN-93G (control, C); extra virgin olive oil (OO) + C; high-oleic sunflower oil (HOSO) + C or atherogenic diet (AT) for 8 weeks; the remaining two groups received AT for 3 weeks and then, the saturated fat was replaced by an oil mixture of soybean oil added with OO or HOSO for 5 weeks. Rats consuming MUFA-rich diets showed the highest body fat, hepatic index and epididymal, intestinal and perirenal fat, and triglycerides. T-chol and non-HDL-chol were increased in HOSO rats but decreased in OO rats. Bone mineral content and density were higher in both OO and HOSO groups than in AT rats. This study casts caution to the generalization of the benefits of MUFA for the treatment of hypercholesterolemia.
authors.affiliation: Department of Biochemistry, School of Dentistry, University of Buenos Aires , Buenos Aires , Argentina .
authors.forename: Elisa V
authors.initials: EV
authors.lastname: Macri
authors.forename: Fima
authors.initials: F
authors.lastname: Lifshitz
authors.forename: Estefania
authors.initials: E
authors.lastname: Alsina
authors.forename: Natalia
authors.initials: N
authors.lastname: Juiz
authors.forename: Valeria
authors.initials: V
authors.lastname: Zago
authors.forename: Christian
authors.initials: C
authors.lastname: Lezón
authors.forename: Patricia N
authors.initials: PN
authors.lastname: Rodriguez
authors.forename: Laura
authors.initials: L
authors.lastname: Schreier
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Boyer
authors.forename: Silvia M
authors.initials: SM
authors.lastname: Friedman
mesh_terms: D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D015519:Bone Density / Q000502:physiology; D004032:Diet / Q000379:methods* / Q000706:statistics & numerical data; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D005229:Fatty Acids, Monounsaturated / Q000097:blood / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000097:blood* / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000503:physiopathology; D008297:Male; D000069463:Olive Oil / Q000008:administration & dosage; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000008:administration & dosage; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood
chemical_list: D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D013024:Soybean Oil
keywords: Body fat distribution; MUFA; bone mineral content; lipid profile; liver fat