title: Incidental adrenal enlargement: an overview from a retrospective study in a chinese population.
abstract: Aim. To investigate incidental adrenal enlargement clinical characteristics and functional status and analyze functional lesion risk factors. Materials and Methods. This retrospective study included 578 patients with adrenal imaging features showing enlargement. Incidental adrenal enlargement cases (78) were considered eligible. Demographics, functional diagnosis, adrenal imaging features, and concomitant diseases were analyzed. Results. The number of adrenal enlargements and proportion of incidental adrenal enlargement increased each year. Mean patient age was 50.32 years. Thirty-nine cases had unilateral enlargement on the left side and 3 on the right side; 36 had bilateral enlargement. Routine medical checkup was found to have the greatest chance (43.59%) of revealing clinical onsets leading to discovery. Biochemical and functional evaluation revealed 54 (69.23%) cases of nonfunctional lesions, 12 (15.38%) of subclinical Cushing syndrome, 6 (7.69%) of primary hyperaldosteronism, 1 (1.28%) of metastasis, and 5 (6.41%) of unknown functional status. Nodular adrenal enlargement (OR, 7.306; 95% CI, 1.727-28.667; P = 0.006) was a risk factor for functional lesions. Age and lesion location were not significant factors. Conclusion. Incidental adrenal enlargement is a frequent radiographic finding and is accompanied by diverse clinical factors that require proper evaluation and management. Nodular adrenal enlargement was a risk factor.
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Le-le
authors.initials: LL
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Gu
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Jing-Tao
authors.initials: JT
authors.lastname: Dou
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yang
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Lv
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Mu
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ju-Ming
authors.initials: JM
authors.lastname: Lu
references.citation: Clin Radiol. 2014 Jan;69(1):e37-42
references.pmid: 24161458
references.citation: BMC Res Notes. 2012 Oct 30;5:602
references.pmid: 23110780
references.citation: Clin Endocrinol (Oxf). 2012 Feb;76(2):182-8
references.pmid: 21895732
references.citation: Eur J Endocrinol. 2008 Dec;159(6):819-24
references.pmid: 18827064
references.citation: Arch Gen Psychiatry. 1992 May;49(5):384-7
references.pmid: 1586274
references.citation: J Endocrinol Invest. 2006 Apr;29(4):298-302
references.pmid: 16699294
references.citation: Ann Surg Oncol. 2003 Dec;10(10):1191-6
references.pmid: 14654476
references.citation: J Clin Endocrinol Metab. 2001 Mar;86(3):1066-71
references.pmid: 11238487
references.citation: J Clin Endocrinol Metab. 2007 Apr;92(4):1358-63
references.pmid: 17284636
references.citation: Radiographics. 2004 Mar-Apr;24(2):435-52
references.pmid: 15026592
references.citation: J Clin Endocrinol Metab. 2008 Sep;93(9):3266-81
references.pmid: 18552288
references.citation: Clin Radiol. 1994 Jul;49(7):456-60
references.pmid: 8088037
references.citation: Curr Opin Endocrinol Diabetes Obes. 2012 Jun;19(3):176-82
references.pmid: 22499224