title: Alterations of dendritic cells in sepsis: featured role in immunoparalysis.
abstract: Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Xia
authors.identifier: 0000-0001-8824-1623
authors.initials: X
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Zheng
authors.identifier: 0000-0003-3223-8403
authors.initials: Z
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: He
authors.identifier: 0000-0001-5130-6358
authors.initials: H
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
authors.forename: Hua-ping
authors.initials: HP
authors.lastname: Liang
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D018448:Models, Immunological; D018805:Sepsis / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D016207:Cytokines
references.citation: Shock. 2012 May;37(5):511-7
references.pmid: 22266972
references.citation: J Immunol. 2005 Sep 1;175(5):3282-6
references.pmid: 16116220
references.citation: J Immunol. 2006 May 1;176(9):5471-7
references.pmid: 16622015
references.citation: Blood. 2002 Sep 1;100(5):1869-77
references.pmid: 12176911
references.citation: J Exp Med. 2010 Nov 22;207(12):2689-701
references.pmid: 21078886
references.citation: Infect Immun. 2009 Dec;77(12):5651-8
references.pmid: 19805530
references.citation: Clin Infect Dis. 2002 Apr 15;34(8):1084-93
references.pmid: 11914997
references.citation: Immunobiology. 2012 Jun;217(6):616-21
references.pmid: 22204813
references.citation: Nature. 2000 May 25;405(6785):421-4
references.pmid: 10839530
references.citation: Mol Cell Biol. 2004 Mar;24(6):2385-96
references.pmid: 14993278
references.citation: Nat Rev Immunol. 2003 Feb;3(2):133-46
references.pmid: 12563297
references.citation: J Biol Chem. 2006 Aug 11;281(32):22429-33
references.pmid: 16793760
references.citation: J Leukoc Biol. 2006 Jan;79(1):235-43
references.pmid: 16380602
references.citation: JAMA. 2008 Jul 23;300(4):413-22
references.pmid: 18647984
references.citation: Physiol Rev. 2002 Jan;82(1):97-130
references.pmid: 11773610
references.citation: J Immunol. 2014 Mar 1;192(5):2357-65
references.pmid: 24489087
references.citation: Nature. 1998 Mar 19;392(6673):245-52
references.pmid: 9521319
references.citation: Blood. 1996 May 15;87(10):4261-75
references.pmid: 8639785
references.citation: Surgery. 2001 Aug;130(2):339-45
references.pmid: 11490369
references.citation: Endocrinology. 2003 Jun;144(6):2201-7
references.pmid: 12746275
references.citation: J Immunol. 2004 Sep 1;173(5):3035-43
references.pmid: 15322163
references.citation: Am J Respir Crit Care Med. 2004 May 15;169(10):1144-51
references.pmid: 15028560
references.citation: Blood. 2005 May 1;105(9):3588-95
references.pmid: 15604223
references.citation: J Immunol. 2010 Feb 1;184(3):1401-9
references.pmid: 20026737
references.citation: Am J Physiol Gastrointest Liver Physiol. 2001 May;280(5):G812-8
references.pmid: 11292588
references.citation: Intensive Care Med. 2010 Jan;36(1):123-30
references.pmid: 19760394
references.citation: J Immunol. 2002 Sep 15;169(6):3223-31
references.pmid: 12218141
references.citation: Crit Care Med. 2003 Jul;31(7):2068-71
references.pmid: 12847405
references.citation: Nat Immunol. 2000 Dec;1(6):496-501
references.pmid: 11101871
references.citation: J Exp Med. 1979 Jan 1;149(1):1-16
references.pmid: 762493
references.citation: J Immunol. 2001 Jun 1;166(11):6952-63
references.pmid: 11359857
references.citation: J Immunol. 2012 Jun 1;188(11):5448-58
references.pmid: 22547701
references.citation: Cell. 1995 Dec 15;83(6):835-9
references.pmid: 8521507
references.citation: Crit Care. 2006;10(3):146
references.pmid: 16762041
references.citation: Blood. 2008 Feb 15;111(4):1797-804
references.pmid: 18055863
references.citation: J Crit Care. 2013 Oct;28(5):881.e7-13
references.pmid: 23787022
references.citation: J Immunol. 1974 Nov;113(5):1583-8
references.pmid: 4473046
references.citation: Am J Pathol. 2006 Jun;168(6):1940-50
references.pmid: 16723709
references.citation: Curr Opin Genet Dev. 2005 Apr;15(2):163-76
references.pmid: 15797199
references.citation: FASEB J. 2004 Feb;18(2):370-2
references.pmid: 14688199
references.citation: Sci Transl Med. 2013 May 15;5(185):185ra64
references.pmid: 23677593
references.citation: Nature. 2007 May 24;447(7143):425-32
references.pmid: 17522676
references.citation: Blood. 2001 Jun 1;97(11):3333-41
references.pmid: 11369621
references.citation: J Immunol. 2011 Jan 15;186(2):977-86
references.pmid: 21160046
references.citation: Annu Rev Immunol. 2006;24:607-56
references.pmid: 16551261
references.citation: Development. 2007 Jan;134(1):3-12
references.pmid: 17138665
references.citation: Eur J Immunol. 2010 Apr;40(4):1022-35
references.pmid: 20101618
references.citation: J Immunol. 2001 Jun 15;166(12):7504-13
references.pmid: 11390504
references.citation: J Immunol. 2003 May 15;170(10):5295-301
references.pmid: 12734379
references.citation: PLoS One. 2013 Jul 23;8(7):e69779
references.pmid: 23936099
references.citation: Nature. 2000 Mar 9;404(6774):193-7
references.pmid: 10724173
references.citation: Arch Surg. 2007 Dec;142(12):1151-7; discussion 1157
references.pmid: 18086981
references.citation: Blood. 2000 Jul 1;96(1):218-23
references.pmid: 10891454
references.citation: Immunology. 1999 May;97(1):45-55
references.pmid: 10447713
references.citation: Infect Control Hosp Epidemiol. 2008 Nov;29(11):1054-65
references.pmid: 18937570
references.citation: Eur J Immunol. 2012 Feb;42(2):341-52
references.pmid: 22105154
references.citation: Nat Rev Cancer. 2008 May;8(5):387-98
references.pmid: 18432252
references.citation: Intensive Care Med. 2011 Sep;37(9):1438-46
references.pmid: 21805160
references.citation: Shock. 2012 Feb;37(2):164-9
references.pmid: 22089192
references.citation: Am J Respir Crit Care Med. 2011 Jul 1;184(1):64-74
references.pmid: 21471100
references.citation: Intensive Care Med. 2007 Jan;33(1):148-52
references.pmid: 17091240
references.citation: Lancet Infect Dis. 2012 Dec;12(12):919-24
references.pmid: 23103175
references.citation: Immunity. 2006 Feb;24(2):153-63
references.pmid: 16473828
references.citation: Curr Opin Genet Dev. 2004 Apr;14(2):155-64
references.pmid: 15196462
references.citation: FASEB J. 2002 Jun;16(8):887-8
references.pmid: 12039868
references.citation: Eur J Immunol. 2004 Aug;34(8):2293-302
references.pmid: 15259027
references.citation: J Immunol. 2007 Feb 15;178(4):2122-31
references.pmid: 17277116
references.citation: J Immunol. 2002 Apr 1;168(7):3412-8
references.pmid: 11907099
references.citation: Eur J Immunol. 2001 Oct;31(10):2857-65
references.pmid: 11592060
references.citation: J Immunol. 2011 Oct 15;187(8):4129-39
references.pmid: 21918189
references.citation: J Immunol. 2003 Jul 15;171(2):909-14
references.pmid: 12847261
references.citation: Cytometry B Clin Cytom. 2011 Jan;80(1):14-21
references.pmid: 20687203
references.citation: J Interferon Cytokine Res. 2014 Jan;34(1):2-15
references.pmid: 24006870
references.citation: J Leukoc Biol. 2003 Sep;74(3):344-51
references.pmid: 12949237
references.citation: Crit Care. 2009;13(4):R119
references.pmid: 19604380
references.citation: Infect Immun. 2012 Jun;80(6):2026-34
references.pmid: 22451518
references.citation: J Immunol. 2004 Oct 1;173(7):4452-63
references.pmid: 15383576
references.citation: Anesth Analg. 2009 Jun;108(6):1841-7
references.pmid: 19448210
references.citation: Shock. 2009 Apr;31(4):359-66
references.pmid: 18838943
references.citation: Scand J Immunol. 2006 May;63(5):330-7
references.pmid: 16640656
references.citation: PLoS One. 2012;7(10):e47209
references.pmid: 23071758
references.citation: J Leukoc Biol. 2008 Oct;84(4):1047-56
references.pmid: 18653461
references.citation: Annu Rev Immunol. 2001;19:683-765
references.pmid: 11244051
references.citation: Cell. 2005 Jun 17;121(6):859-72
references.pmid: 15960974
references.citation: Blood. 2007 Jan 15;109(2):643-52
references.pmid: 16968896
references.citation: Nat Med. 1997 Oct;3(10):1124-8
references.pmid: 9334724
references.citation: PLoS One. 2012;7(9):e43860
references.pmid: 23024745
references.citation: J Exp Med. 2000 Mar 6;191(5):771-80
references.pmid: 10704459
references.citation: J Immunol. 2005 Jun 1;174(11):7398-402
references.pmid: 15905588
references.citation: Crit Care. 2013 Dec 09;17(6):1022
references.pmid: 24321139
references.citation: Immunity. 2009 Jun 19;30(6):845-59
references.pmid: 19523851
references.citation: Curr Opin Immunol. 2013 Aug;25(4):477-83
references.pmid: 23725873
references.citation: Blood. 2011 Jun 9;117(23):6172-83
references.pmid: 21474672
references.citation: Immunity. 2007 Jun;26(6):741-50
references.pmid: 17582346
references.citation: Cell. 2005 Jun 17;121(6):873-85
references.pmid: 15960975
references.citation: Shock. 2003 Nov;20(5):386-401
references.pmid: 14560102
references.citation: Immunol Rev. 2010 Mar;234(1):105-19
references.pmid: 20193015
references.citation: Blood. 2007 Nov 15;110(10):3591-660
references.pmid: 17664352
references.citation: J Leukoc Biol. 2012 Sep;92(3):593-603
references.pmid: 22459947
references.citation: Blood. 2006 Aug 1;108(3):965-73
references.pmid: 16601243
references.citation: Cytokine. 2006 Apr;34(1-2):96-105
references.pmid: 16730193
references.citation: Crit Care Med. 2013 Mar;41(3):820-32
references.pmid: 23348516
references.citation: Nature. 2009 Jul 9;460(7252):264-8
references.pmid: 19525933
references.citation: Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R84-92
references.pmid: 17989144
references.citation: Clin Exp Immunol. 2007 Mar;147(3):426-39
references.pmid: 17302891
references.citation: Int J Infect Dis. 2014 Mar;20:13-7
references.pmid: 24445225
references.citation: Annu Rev Immunol. 2000;18:767-811
references.pmid: 10837075
references.citation: J Leukoc Biol. 2006 Mar;79(3):473-81
references.pmid: 16365154
references.citation: J Immunol. 2005 Jan 1;174(1):404-10
references.pmid: 15611264
references.citation: J Endotoxin Res. 2005;11(6):375-82
references.pmid: 16303094
references.citation: J Leukoc Biol. 2008 Mar;83(3):439-46
references.pmid: 17991763
references.citation: Expert Opin Biol Ther. 2007 Jul;7(7):929-38
references.pmid: 17665984
references.citation: Infect Immun. 2011 May;79(5):1848-54
references.pmid: 21343350
references.citation: Shock. 2005 Jun;23(6):507-15
references.pmid: 15897802
references.citation: Crit Care Med. 2002 May;30(5):1015-23
references.pmid: 12006796
references.citation: Cell. 1999 Aug 6;98(3):285-94
references.pmid: 10458604
references.citation: Clin Cancer Res. 2007 Jul 15;13(14):4042-5
references.pmid: 17634527
references.citation: Crit Care Med. 2002 Jan;30(1 Supp):S58-S63
references.pmid: 11839946
references.citation: J Exp Med. 1973 May 1;137(5):1142-62
references.pmid: 4573839
references.citation: Immunol Cell Biol. 1999 Oct;77(5):404-10
references.pmid: 10540206
references.citation: Shock. 2004 Aug;22(2):137-44
references.pmid: 15257086
references.citation: Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):504-10
references.pmid: 18174455
references.citation: J Immunol. 2008 Sep 15;181(6):3955-64
references.pmid: 18768850