title: Lipomatous angiomyofibroblastoma of the vulva: diagnostic and histogenetic considerations.
abstract: We report a rare case of angiomyofibroblastoma (AMFB) of the vulva, composed predominantly of a mature fatty component, representing approximately 60% of the entire tumour. The tumour, designated as "lipomatous AMFB", should be interpreted as the morphological result of an unbalanced bidirectional differentiation of the presumptive precursor stromal cell resident in the hormonally-responsive stroma of the lower genital tract, with the adipocytic component overwhelming the fibroblastic/myofibroblastic one. The close admixture of adipocytes with spindled/epithelioid cells of the conventional AMFB resulted, focally, in a pseudo-infiltrative growth pattern and pseudo-lipoblast-like appearance, raising problems in differential diagnosis, especially with well-differentiated lipoma-like liposarcoma and spindle cell liposarcoma. Awareness of the possibility that vulvo-vaginal AMFB may contain large amount of lipomatous component is crucial to avoid confusion with other bland-looking spindle cell tumours containing infiltrating fat.
authors.forename: G
authors.initials: G
authors.lastname: Magro
authors.forename: L
authors.initials: L
authors.lastname: Salvatorelli
authors.forename: G
authors.initials: G
authors.lastname: Angelico
authors.forename: G M
authors.initials: GM
authors.lastname: Vecchio
authors.forename: R
authors.initials: R
authors.lastname: Caltabiano
mesh_terms: D017667:Adipocytes / Q000473:pathology; D018207:Angiomyolipoma / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*