title: Intraoperative fluorescein angiography-guided treatment in children with early Coats' disease.
abstract: OBJECTIVE
  To review the anatomic and visual outcomes of a series of children diagnosed with Coats' disease and treated on the basis of intraoperative fluorescein angiography (FA) findings.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Twenty-five children 2 to 15 years of age diagnosed with early Coats' disease and treated after intraoperative FA.
  
  
  METHODS
  Retrospective review of patients who underwent treatment for stage 2 Coats' disease in a tertiary center in the United Kingdom between 2007 and 2012. The children underwent treatment to the telangiectatic vessels and associated areas of retinal nonperfusion identified on intraoperative FA performed with a wide-angle retinal camera (RetCam II).
  
  
  METHODS
  Anatomic and structural assessment of the retina after treatment, visual acuity (VA), and complications related to treatment.
  
  
  RESULTS
  Twenty children with Coats' disease who underwent intraoperative RetCam FA and retinal ablative treatment and who had more than 3 months of follow-up were identified from clinical records. All had unilateral disease. Six eyes were classified as stage 2a, and 14 eyes were classified as stage 2b. The median duration of follow-up was 21 months (mean, 26 months). Fifteen eyes needed 1 treatment to stabilize the disease, and 5 eyes needed a second treatment. None of the patients demonstrated progression of the disease to a more severe stage. Twelve eyes had a final VA of 0.4 logarithm of the minimum angle of resolution (logMAR) or better, 6 patients had VA between 0.4 and 1.0 logMAR, and 2 patients had VA worse than 1.0 logMAR.
  
  
  CONCLUSIONS
  The treatment of retinal telangiectasia and areas of retinal nonperfusion identified by wide-angle intraoperative FA in children with stage 2 Coats' disease led to good anatomic outcome, with preservation of VA in most cases.
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom; Department of Ophthalmology, San Gerardo Hospital, Monza, Italy.
authors.forename: Martina
authors.initials: M
authors.lastname: Suzani
authors.affiliation: Moorfields Eye Hospital, London, United Kingdom; Institute of Ophthalmology, University College London, London, United Kingdom; Department of Ophthalmology, University of California, San Francisco, California. Electronic address: tony.moore@ucsf.edu.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Moore
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007432:Intraoperative Period; D017075:Laser Coagulation; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D058456:Retinal Telangiectasis / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology