title: Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematologic malignancies: A retrospective single-center study.
abstract: OBJECTIVE
  This study investigated the feasibility of high-flow nasal cannula (HFNC) oxygen therapy for acute respiratory failure in adult patients with hematologic malignancies.
  
  
  METHODS
  We identified 45 acute respiratory failure patients with hematologic malignancies who received HFNC therapy between March 2012 and June 2014 at Seoul St Mary's Hospital. Their medical records were reviewed retrospectively to identify useful prognostic factors for successful treatment.
  
  
  RESULTS
  Of the 45 patients, 15 (33.3%) successfully recovered, and 30 were changed to invasive ventilation due to failed HFNC treatment. The etiologies of acute respiratory failure were bacterial pneumonia (57.8%), Pneumocystis jirovecii pneumonia (17.8%), pulmonary edema (8.9%), and bronchiolitis obliterans organizing pneumonia (8.9%). The overall mortality rate was 62.2%. The HFNC treatment success rate was significantly different between the survivors and nonsurvivors. To evaluate risk factors for HFNC treatment failure, differences between the HFNC treatment success and failure groups were compared. There were no significant differences in the severity of underlying medical conditions. The percentage of bacterial pneumonia was significantly higher in the HFNC treatment failure group compared with the success group (73.3% vs 26.7%; P = .004).
  
  
  CONCLUSIONS
  High-flow nasal cannula offers an interesting alternative to invasive ventilation in acute respiratory failure patients with hematologic malignancies. However, attention must be paid to the appropriate choice of HFNC settings such as oxygen flow.
authors.affiliation: Division of Respiratory, Allergy and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: lehwyo@catholic.ac.kr.
authors.forename: Hwa Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Division of Respiratory, Allergy and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: chinkook@catholic.ac.kr.
authors.forename: Chin Kook
authors.initials: CK
authors.lastname: Rhee
authors.affiliation: Division of Hematology, Catholic Blood and Marrow Transplantation Center, Seoul St Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: jwlee@catholic.ac.kr.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D057785:Catheters; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications*; D005240:Feasibility Studies; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D063087:Noninvasive Ventilation; D010100:Oxygen; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D018410:Pneumonia, Bacterial / Q000150:complications*; D011020:Pneumonia, Pneumocystis / Q000150:complications*; D011654:Pulmonary Edema / Q000150:complications*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D010100:Oxygen
keywords: Acute respiratory failure; Hematologic malignancy; High-flow oxygen therapy