title: Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease.
abstract: The human genome project has revolutionized our understanding of the underlying mechanisms in psychiatric disease. It is now abundantly clear that neurobehavioral phenotypes are epigenetically controlled by noncoding RNAs (ncRNAs). The microRNA (miRNA) class of ncRNAs are ubiquitously expressed throughout the brain and govern all major neuronal pathways. The attractive therapeutic potential of miRNAs is underscored by their pleiotropic capacities, putatively targeting multiple pathways within a single neuron. Many psychiatric diseases stem from a multifactorial origin, thus conventional drug targeting of single proteins may not prove most effective. In this exciting post-genome sequencing era, many new epigenetic targets are emerging for therapeutic investigation. Here we review the reported roles of miRNAs, as well as other ncRNA classes, in the pathology of psychiatric disorders; there are both common and unique ncRNA mechanisms that influence the various diagnoses. Collectively, these potent epigenetic regulators may clarify the disrupted signaling networks in psychiatric phenotypes.
authors.affiliation: Department of Chemistry, Georgia Southern University, PO Box 8064, Statesboro, GA 30460, USA.
authors.forename: Jannet
authors.initials: J
authors.lastname: Kocerha
authors.affiliation: Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL 35294-0017.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Dwivedi
authors.affiliation: Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, 9-20B New York, NY 10029, USA.
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Brennand
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000209:etiology*; D006801:Humans; D001523:Mental Disorders / Q000150:complications* / Q000235:genetics*; D009422:Nervous System Diseases / Q000209:etiology*; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism
chemical_list: D022661:RNA, Untranslated
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