title: Poly(ethylene glycol) grafted polylactide based copolymers for the preparation of PLA-based nanocarriers and hybrid hydrogels.
abstract: In previous works, poly(D,L-lactide-co-ɛCL-poly(ethylene glycol) (poly(D,L-La-co-αPEGɛCL) amphiphilic graft-copolymers were successfully synthesized according to a copper azide-alkyne cycloaddition (CuAAC) strategy. This paper aims at reporting on the behavior of this amphiphilic copolymer in water, which was not studied in the previous paper. Moreover, the ability of the copolymer to stabilize a PLA nanoparticles aqueous suspension is presented. For this purpose, dynamic light scattering (DLS) and transmission electron microscopy (TEM) are proposed to characterize the nanoparticles in solution. Otherwise, the strategy developed for the synthesis of the amphiphilic copolymers was adapted and extended to the synthesis of PLA-based degradable hydrogel, potentially applicable as drug-loaded degradable polymer implant.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Riva
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Schmeits
authors.forename: Florence
authors.initials: F
authors.lastname: Croisier
authors.forename: Philippe
authors.initials: P
authors.lastname: Lecomte
authors.forename: Christine
authors.initials: C
authors.lastname: Jérôme
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D053758:Nanoparticles; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis; D012996:Solutions; D014867:Water
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D011091:Polyesters; D011108:Polymers; D012996:Solutions; D014867:Water; D011092:Polyethylene Glycols; C033616:poly(lactide); C083464:poly(ethyleneglycol-lactide)
keywords: Amphiphilic copolymers; aliphatic polyesters; degradable hydrogel; drug delivery