title: Investigation of the vitamin D receptor polymorphisms in acromegaly patients.
abstract: OBJECTIVE
  The genetic structural alterations in the majority of somatotroph adenomas are not clarified and the search for novel candidate genes is still a challenge. We aimed to investigate possible associations between vitamin D receptor (VDR) polymorphisms and acromegaly.
  
  
  METHODS
  52 acromegaly patients (mean age 45.7 ± 1.9 years) and 83 controls (mean age 43.1 ± 2.6 years) were recruited to the study. VDR polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism methods.
  
  
  RESULTS
  The distribution of VDR genotypes showed a significant difference in the frequencies of VDR FokI genotypes between patients and controls (P = 0.034). VDR FokI ff genotype was significantly decreased in acromegaly patients (P = 0.035) and carriers of FokI Ff genotype had a 1.5-fold increased risk for acromegaly (OR: 1.5, 95% CI: 1.07-2.1; P = 0.020). IGF1 levels after treatment were significantly higher in patients carrying the Ff genotype compared to carrying ff genotype (P = 0.0049). 25(OH)D3 levels were significantly lower in acromegaly patients (P < 0.001).
  
  
  CONCLUSIONS
  Our study suggests that VDR FokI genotypes might affect the development of acromegaly and VDR polymorphisms may play a role in the course of acromegaly as a consequence of altering hormonal status.
authors.affiliation: Department of Endocrinology and Metabolism, Bezmialem University, 34093 Istanbul, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Ilhan
authors.affiliation: Department of Molecular Medicine, The Institute of Experimental Medicine, 34093 Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Toptas-Hekimoglu
authors.affiliation: Department of Molecular Medicine, The Institute of Experimental Medicine, 34093 Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylim
authors.affiliation: Department of Internal Medicine, Bezmialem University, 34093 Istanbul, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Turgut
authors.affiliation: Department of Molecular Medicine, The Institute of Experimental Medicine, 34093 Istanbul, Turkey.
authors.forename: Saime
authors.initials: S
authors.lastname: Turan
authors.affiliation: Department of Endocrinology and Metabolism, Bezmialem University, 34093 Istanbul, Turkey.
authors.forename: Ozcan
authors.initials: O
authors.lastname: Karaman
authors.affiliation: Department of Endocrinology and Metabolism, Bezmialem University, 34093 Istanbul, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Tasan
mesh_terms: D000172:Acromegaly / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol
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