title: [Changes in portal vein and hepatic vein blood flow volume and their ratio in SD rats during induced carcinogenesis of hepatocellular carcinoma].
abstract: OBJECTIVE
  To explore the feasibility and reliability of ultrasonic monitoring of portal vein (PV) and hepatic vein (HV) blood flow volume changes in the process of induced carcinogenesis of hepatocellular carcinoma and the correlation of PV/HV blood flow volume ratio (Qpv/Qhv) with the severity of liver cirrhosis.
  
  
  METHODS
  SD rats with diethylnitrosamine-induced liver carcinogenesis underwent regular liver ultrasound examinations including color flow imaging and pulsed Doppler examination. The main PV and HV blood flow parameters were measured to calculate Qpv/Qhv until successful induction of liver cancer.
  
  
  RESULTS
  The PV diameter increased significantly with the severity of liver cirrhosis in the rats (P<0.05), and the PV blood flow velocity reduced but the blood flow volume increased significantly in liver cancer and cirrhosis stages (P<0.05). Normal hepatic vein blood flow was significantly greater than that measured in liver cirrhosis and hepatocellular carcinoma stages. The Qpv/Qhv measured in normal rats was significantly lower than that in liver cirrhosis and liver cancer stages, but the ratios were comparable between the latter two stages.
  
  
  CONCLUSIONS
  Ultrasonography is reliable to monitor the change of liver hemodynamics in rats with induced liver carcinogenesis, in which the changes of Qpv/Qhv are correlated with the severity of liver cirrhosis.
authors.affiliation: Department of Ultrasound Diagnosis, Hunan Provincial People's Hospital, Changsha 410005, China.E-mail: weian1976@163.com.
authors.forename: An
authors.initials: A
authors.lastname: Wei
authors.forename: Hongtian
authors.initials: H
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Keyi
authors.initials: K
authors.lastname: Wang
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001810:Blood Volume; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000000981:diagnostic imaging; D006439:Hemodynamics; D006503:Hepatic Veins; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D011169:Portal Vein; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D014463:Ultrasonography