title: [Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states].
abstract: It is established that activation of delta1 opioid receptors with their selective agonist DPDPE(100 μg/kg) significantly increases IgM immune response not only in C57BL/6J mice with unchanged psychoemotional state, but also in mice displaying aggressive or depressive-like behavior in the social stress model (10 days of agonistic confrontations). SCH-23390 (1.0 mg/kg), selective antagonist of dopamine D1 receptors, and selective D2 receptor blocker haloperidol (1 mg/kg) prevented the immunostimulating effect of DPDPE in animals not subjected to social stress. At the same time, both SCH-23390 and haloperidol did not affect DPDPE-induced immunostimulation in mice engaged in aggressive or depressive-like behaviors.
authors.forename: M A
authors.initials: MA
authors.lastname: Cheĭdo
authors.forename: G V
authors.initials: GV
authors.lastname: Idova
mesh_terms: D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy / Q000276:immunology* / Q000523:psychology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D020881:Enkephalin, D-Penicillamine (2,5)- / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D006220:Haloperidol / Q000494:pharmacology; D007114:Immunization; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D017465:Receptors, Opioid, delta / Q000378:metabolism; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D013315:Stress, Psychological / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000701:Analgesics, Opioid; D001552:Benzazepines; D018492:Dopamine Antagonists; D007075:Immunoglobulin M; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D017465:Receptors, Opioid, delta; C534628:SCH 23390; D020881:Enkephalin, D-Penicillamine (2,5)-; D006220:Haloperidol