title: Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development.
abstract: Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle, the developmental signals that control the formation of BAT remain largely unknown. Here, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signaling. Furthermore, cell-autonomous activation of Hh signaling blocks early brown-preadipocyte differentiation, inhibits BAT formation in vivo, and results in replacement of neck BAT with poorly differentiated skeletal muscle. Finally, we show that Hh signaling inhibits BAT formation partially through up-regulation of chicken ovalbumin upstream promoter transcription factor II (COUP-TFII). Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of BAT development.
authors.affiliation: United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; and.
authors.forename: LaGina
authors.initials: L
authors.lastname: Nosavanh
authors.affiliation: United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; and.
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Yu
authors.affiliation: Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California School of Medicine, San Diego, La Jolla, CA 92093-0669.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Jaehnig
authors.affiliation: United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; and.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tong
authors.affiliation: United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; and.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Shen
authors.affiliation: United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030; and miaohsuc@bcm.edu.
authors.forename: Miao-Hsueh
authors.initials: MH
authors.lastname: Chen
mesh_terms: D052437:Adipocytes, Brown / Q000166:cytology / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D000818:Animals; D051837:COUP Transcription Factor II / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D002923:Cilia / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000235:genetics; D015854:Up-Regulation / Q000235:genetics
chemical_list: D051837:COUP Transcription Factor II; D053823:Hedgehog Proteins
keywords: Hedgehog signaling; brown adipose tissue; cell fate
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