title: Vitreous estrogen levels in patients with an idiopathic macular hole.
abstract: OBJECTIVE
  Estrogen, a female hormone, activates collagenase and might be associated with the pathogenesis of vitreoretinal collagen fiber disease. The purpose of the present study was to investigate the vitreous levels of estrone (E1) and estradiol (E2) in subjects with an idiopathic macular hole (IMH).
  
  
  METHODS
  Vitreous samples were obtained from ten female patients with an IMH and from nine female patients with other retinal diseases (six with rhegmatogenous retinal detachment and three with age-related macular degeneration) as a control at the time of vitreous surgery. E1 and E2 levels in the vitreous samples were then determined using the Coat-A-Count(®) Estradiol Radioimmunoassay (RIA) Kit and the DSL-70 Estrone RIA Kit, respectively.
  
  
  RESULTS
  The mean vitreous levels of E1 and E2 in the subjects with IMH were 1.83±2.00 pg/mL and 7.03±2.97 pg/mL, respectively, whereas in the control subjects they were 2.42±1.25 pg/mL and 4.90±2.90 pg/mL, respectively. Thus, the vitreous E2 levels in the subjects with IMH were significantly higher than in the controls (P<0.05).
  
  
  CONCLUSIONS
  The findings of this study suggest that E2 might be associated with the pathogenesis of IMH, but further investigation is needed to elucidate that association.
authors.affiliation: Inokuchi Eye Clinic, Suita-City Osaka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Inokuchi
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Ikeda
authors.affiliation: Nakamura Eye Clinic, Matsumoto-City, Nagano, Japan.
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
authors.forename: Seita
authors.initials: S
authors.lastname: Morishita
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Fukumoto
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
authors.forename: Teruyo
authors.initials: T
authors.lastname: Kida
authors.affiliation: Department of Ophthalmology, Osaka Medical College, Takatsuki-City, Osaka, Japan.
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oku
keywords: estradiol; estrone; idiopathic macular hole; radioimmunoassay; vitreous surgery
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