title: Radiofrequency ablation for neuroendocrine liver metastases: a systematic review.
abstract: To determine the efficacy of radiofrequency (RF) ablation in neuroendocrine tumor (NET) liver metastases. A systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eight studies were included (N = 301). Twenty-six percent of RF ablation procedures were percutaneous (n = 156), with the remainder conducted at surgery. Forty-eight percent of patients had a concomitant liver resection. Fifty-four percent of patients presented with symptoms, with 92% reporting symptom improvement following RF ablation (alone or in combination with surgery). The median duration of symptom improvement was 14-27 months. However, recurrence was common (63%-87%). RF ablation can provide symptomatic relief in NET liver metastases alone or in combination with surgery.
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland. Electronic address: helen.mohan@gmail.com.
authors.forename: Helen
authors.initials: H
authors.lastname: Mohan
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Nicholson
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Des C
authors.initials: DC
authors.lastname: Winter
authors.affiliation: Department of Radiology, and Endocrinology, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Donal
authors.initials: D
authors.lastname: O'Shea
authors.affiliation: Department of Clinical Medicine and Gastroenterology, Trinity Centre for Health Sciences, St. James Hospital and Trinity College Dublin, Dublin, Ireland.
authors.forename: Dermot
authors.initials: D
authors.lastname: O'Toole
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Justin
authors.initials: J
authors.lastname: Geoghegan
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Donal
authors.initials: D
authors.lastname: Maguire
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Emir
authors.initials: E
authors.lastname: Hoti
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Oscar
authors.initials: O
authors.lastname: Traynor
authors.affiliation: Department of Surgery, St. Vincent's University Hospital, Dublin, Ireland.
authors.forename: Colin P
authors.initials: CP
authors.lastname: Cantwell
mesh_terms: D017115:Catheter Ablation / Q000009:adverse effects / Q000401:mortality; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D018358:Neuroendocrine Tumors / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome