title: Molecular portraits: the evolution of the concept of transcriptome-based cancer signatures.
abstract: Cancer results from dysregulation of multiple steps of gene expression programs. We review how transcriptome profiling has been widely explored for cancer classification and biomarker discovery but resulted in limited clinical impact. Therefore, we discuss alternative and complementary omics approaches.
authors.forename: Angelika
authors.initials: A
authors.lastname: Modelska
authors.forename: Alessandro
authors.initials: A
authors.lastname: Quattrone
authors.forename: Angela
authors.initials: A
authors.lastname: Re
mesh_terms: D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D020543:Proteome; D059467:Transcriptome
chemical_list: D009363:Neoplasm Proteins; D020543:Proteome
keywords: cancer; heterogeneity; omics; signatures; transcriptomes
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