title: French survey of the first three-years of liver transplantation activity from uncontrolled donors deceased after cardiac death.
abstract: OBJECTIVE
  To assess the first three years of French activity related to liver transplantation from uncontrolled donation after cardiac death (uDCD).
  
  
  METHODS
  Prospective and observational study in the three active centres authorized by the French Biomedicine Agency.
  
  
  METHODS
  All patients deceased between 2010 and 2012 after an uncontrolled cardiac arrest admitted to one of three centres (Pitié-Salpêtrière, Saint-Louis or Bicêtre hospitals, AP-HP, Paris, France) and potentially eligible for liver recovery were included. Abdominal normothermic oxygenated recirculation (ANOR) was used for graft preservation.
  
  
  RESULTS
  One hundred twenty-six potential uDCD donors were identified as eligible for liver recovery after hospital admission. The main causes of organ recovery failure were technical failure related to ANOR (29 patients, 23%), refusal of consent (39 patients, 31% of potential uDCD donors and 40% of asked relatives) and abnormal hepatic transaminases up to 200 UI.L(-1) during ANOR (24 patients, 19%). Finally, 11 livers were transplanted. Process efficiency was 9% [95% CI: 4-15%]. One-year recipient survival was 82%, [95% CI: 48-98%] and one-year graft survival was 64% [95% CI: 31-89%].
  
  
  CONCLUSIONS
  Liver transplantation from uDCD donors is achievable in France, despite low process efficiency.
authors.affiliation: Department of Anesthesiology and Critical Care, groupe hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Champigneulle
authors.affiliation: Department of Anesthesiology and Critical Care & Organ Transplant Coordination Team, hôpital Saint-Louis, AP-HP, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fieux
authors.affiliation: Department of Anesthesiology and Critical Care & Organ Transplant Coordination Team, hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France.
authors.forename: G
authors.initials: G
authors.lastname: Cheisson
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Department, hôpital Beaujon, AP-HP, Clichy, France.
authors.forename: F
authors.initials: F
authors.lastname: Dondero
authors.affiliation: Hepatobiliary Surgery and Liver Transplantation Department, groupe hospitalier Pitié-Salpêtrière, AP-HP, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Savier
authors.affiliation: Department of Emergency Medicine and Surgery, groupe hospitalier Pitié-Salpêtrière, AP-HP, Paris, France; UMRS Inserm 956, université médecine Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Riou
authors.affiliation: Department of Anesthesiology and Critical Care, groupe hospitalier Pitié-Salpêtrière, AP-HP, Paris, France; UMRS Inserm 956, université médecine Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Langeron
authors.affiliation: Department of Anesthesiology and Critical Care, groupe hospitalier Pitié-Salpêtrière, AP-HP, Paris, France; UMRS Inserm 956, université médecine Pierre-et-Marie-Curie-Paris 6, 4, place Jussieu, 75005 Paris, France. Electronic address: armelle.nicolas-robin@psl.aphp.fr.
authors.forename: A
authors.initials: A
authors.lastname: Nicolas-Robin
mesh_terms: D000328:Adult; D023381:Endpoint Determination; D005260:Female; D005602:France; D006085:Graft Survival; D019538:Health Care Surveys; D006323:Heart Arrest; D006801:Humans; D008102:Liver Circulation / Q000502:physiology; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000592:standards*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014019:Tissue Donors / Q000706:statistics & numerical data*; D020858:Tissue and Organ Harvesting / Q000592:standards*
keywords: Donation after cardiac death; Extracorporeal membranous oxygenation; Liver transplant; Organ