title: An epigenomic road map for endoderm development.
abstract: While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives pancreas and liver.
authors.affiliation: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, 3400 Civic Center Boulevard, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: kaestner@mail.med.upenn.edu.
authors.forename: Klaus H
authors.initials: KH
authors.lastname: Kaestner
mesh_terms: D053595:Embryonic Stem Cells / Q000502:physiology*; D004707:Endoderm / Q000502:physiology*; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005775:Gastrula / Q000502:physiology*; D006801:Humans; D010179:Pancreas / Q000502:physiology*