title: Efficacy of linezolid, teicoplanin, and vancomycin in prevention of an experimental polytetrafluoroethylene graft infection model caused by methicillin-resistant Staphylococcus aureus.
abstract: BACKGROUND
  The aim of this study was to evaluate the effectiveness of linezolid, teicoplanin, and vancomycin in prevention of prosthetic vascular graft infections in a vascular graft infection model.
  
  
  METHODS
  Fifty rats were divided into 5 groups. A polytetrafluoroethylene graft was implanted on the back of each rat. Methicillin-resistant Staphylococcus aureus (MRSA) strain was inoculated into all rats except Group 1. Group 2 was not given any treatment, Group 3 received linezolid, Group 4 received vancomycin, and Group 5 received teicoplanin. The grafts were removed for microbiological and histological examinations on the 7th day. In addition, C-reactive protein and prealbumin levels and leukocyte counts in obtained blood specimens were determined.
  
  
  RESULTS
  Group 1 did not have infection. Group 2 had bacteria 5.7 × 10(4) CFU/cm(2). Group 3 and Group 4 had less bacterial growth. Group 5 had no bacterial growth. The number of bacteria was significantly higher in Group 2 than in the other experimental groups and the control group (p<0.001). Although there was no bacterial growth in Group 5, it did not significantly differ from Group 3 and Group 4. Group 2 had a significantly higher CRP level and leukocyte count and a significantly lower prealbumin level than the other groups.
  
  
  CONCLUSIONS
  Linezolid, teicoplanin, and vancomycin are effective in prevention of prosthetic vascular graft infections.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Mese
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Bozoglan
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Serdal
authors.initials: S
authors.lastname: Elveren
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Erdinc
authors.initials: E
authors.lastname: Eroglu
authors.affiliation: Department of Microbiology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gul
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Celik
authors.affiliation: Department of Pathology, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Harun
authors.initials: H
authors.lastname: Ciralik
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Yildirimdemir
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Kahramanmaraş Sutcu Imam University, Kahramanmaraş, Turkey.
authors.forename: Alptekin
authors.initials: A
authors.lastname: Yasim
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D004195:Disease Models, Animal; D007962:Leukocytes / Q000473:pathology; D000069349:Linezolid / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000502:physiology*; D011138:Polytetrafluoroethylene / Q000009:adverse effects*; D011228:Prealbumin / Q000378:metabolism; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D017208:Rats, Wistar; D017334:Teicoplanin / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014640:Vancomycin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D011228:Prealbumin; D017334:Teicoplanin; D014640:Vancomycin; D011138:Polytetrafluoroethylene; D002097:C-Reactive Protein; D000069349:Linezolid
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