title: Physiological roles of miR-155.
abstract: miR-155 is involved in non-coding microRNAs found in humans, mice and chickens of which the sequence is conserved. Historically, miR-155 was identified as a B-cell integration cluster (bic), which induces B-cell leucosis in chickens, by its activation through viral promoter insertion. Subsequent studies have shown that transgenic mice expressing miR-155 in B cells generated lymphoma, showing that miR-155 is oncogenic. Biochemical investigation identifies many substrates of miR-155, and one of them in B cells and macrophages is the SH2-domain containing inositol-5'-phosphatase 1. A deficiency of miR-155 in the immune system causes attenuated immune functions. Clinically, several types of malignancy including diffuse large B-cell lymphoma have high miR-155 expression levels.
authors.affiliation: Department of Microbiology and Immunology, Keio University, School of Medicine, Shinjuku-ku, Tokyo, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Mashima
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
chemical_list: C524942:MIRN155 microRNA, human; D035683:MicroRNAs
keywords: SH2-domain containing inositol-5′-phosphatase 1; inflammation; microRNA; signal transduction; tyrosine kinase
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