title: Increased carotid artery intima-media thickness in patients with tympanosclerosis: Common risk factors with atherosclerosis?
abstract: We investigated the relationship between tympanosclerosis, known atherosclerotic risk factors, and the intima-media thickness of bilateral carotid arteries using ultrasonography. A total of 122 patients admitted to our clinic with chronic otitis media between 2005 and 2010 were included in the study. The study group consisted of 61 patients with tympanosclerosis; the control group comprised 61 patients without tympanosclerosis. Internal carotid artery intima-media thickness (CAIMT), total cholesterol, triglyceride, low- and high-density lipoprotein cholesterol, C-reactive protein, and homocysteine levels were measured in all patients. Homocysteine, low-density lipoprotein, total cholesterol, and triglyceride levels in the study group were higher compared with those of the control group (p < 0.05). Right and left CAIMT was greater in the study group versus the control group (p ≤ 0.001). In conclusion, atherosclerosis and tympanosclerosis were associated with identical risk factors; in the tympanosclerosis group, CAIMT was increased significantly.
authors.affiliation: Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey. Electronic address: sumeyradoluoglu@gmail.com.
authors.forename: Sumeyra
authors.initials: S
authors.lastname: Doluoglu
authors.affiliation: Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Celil
authors.initials: C
authors.lastname: Gocer
authors.affiliation: Department of Radiology, II Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Toprak
authors.affiliation: Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Iriz
authors.affiliation: Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Uyar
authors.affiliation: Department of ENT, III Clinic of Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Adil
authors.initials: A
authors.lastname: Eryilmaz
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000473:pathology; D002339:Carotid Arteries / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063371:Myringosclerosis / Q000473:pathology*; D012307:Risk Factors
keywords: Atherosclerosis; Carotid artery; Tympanosclerosis
references.citation: J Laryngol Otol. 2011 Nov;125(11):1121-4
references.pmid: 21888743
references.citation: Atherosclerosis. 1998 Nov;141(1):1-15
references.pmid: 9863534
references.citation: Atherosclerosis. 2003 Jan;166(1):111-7
references.pmid: 12482557
references.citation: N Engl J Med. 1987 May 28;316(22):1371-5
references.pmid: 3574413
references.citation: J Otolaryngol. 1989 Aug;18(5):229-31
references.pmid: 2769837
references.citation: Free Radic Biol Med. 1996;20(5):707-27
references.pmid: 8721615
references.citation: Clin Otolaryngol Allied Sci. 1991 Oct;16(5):457-61
references.pmid: 1742892
references.citation: Eur Arch Otorhinolaryngol. 2001 Jan;258(1):16-9
references.pmid: 11271428
references.citation: Clin Chem. 1995 Mar;41(3):340-2
references.pmid: 7882507
references.citation: N Engl J Med. 2004 Apr 1;350(14):1387-97
references.pmid: 15070788
references.citation: Eur Arch Otorhinolaryngol. 2002 Apr;259(4):180-3
references.pmid: 12064505
references.citation: Am J Cardiol. 1995 Mar 1;75(7):455-9
references.pmid: 7863988
references.citation: Arch Otolaryngol Head Neck Surg. 1989 Aug;115(8):931-5
references.pmid: 2751852
references.citation: Circulation. 2001 Apr 3;103(13):1813-8
references.pmid: 11282915
references.citation: Am J Physiol Endocrinol Metab. 2005 May;288(5):E1002-10
references.pmid: 15644462
references.citation: Klin Wochenschr. 1988;66 Suppl 11:58-65
references.pmid: 3054282
references.citation: Int Angiol. 2004 Jun;23(2):144-6
references.pmid: 15507892
references.citation: Nat Med. 1996 Apr;2(4):386-9
references.pmid: 8597939