title: [Mesenchymal stem sell donor age effect on the cerebral cortex microvascular net density in old age rats-recipients of transplant].
abstract: Male Wistar-Kyoto rats aged 22-24 months were intracerebrally transplanted with syngenic bone marrow mesenchymal stem cells (BM MSC) established from the donor aged 3-4 months and 20-22 months, respectively. Using a TV device to study microcirculation in vivo, we have established that transplantation of BM MSC from young donors increased a density of the microvascular network in the pia mater of the sensorimotor cortex in old rats approximately 1.9-fold, comparing to age-matched controls, while a density of the arteriolar compartment increased approximately 2.1-fold. Transplantation of BM MSC from old donors did not lead to the significant increase in the density of the microvascular network in the pia mater, while a density of the arteriolar compartment increased approximately 1.5-fold.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: S V
authors.initials: SV
authors.lastname: Anisimov
authors.forename: M V
authors.initials: MV
authors.lastname: Puzanov
authors.forename: I V
authors.initials: IV
authors.lastname: Sergeev
authors.forename: D P
authors.initials: DP
authors.lastname: Dvoretskiĭ
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000166:cytology; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D055806:Microvessels / Q000166:cytology*; D018919:Neovascularization, Physiologic; D010841:Pia Mater / Q000098:blood supply* / Q000166:cytology; D011921:Rats, Inbred WKY