title: Acute necrotizing pancreatitis: can tigecycline be included in a therapeutic strategy?
abstract: BACKGROUND
  Acute necrotizing pancreatitis is a severe and life-threatening disease. Infection, which occurs in about 30% of cases, is the most feared complication. Antibiotic therapy is still discussed and there are no clear recommendation in literature. These clinical series underline the importance of having a clear antibiotic protocol, including tigecycline, in the management of acute necrotizing pancreatitis. Clinical series. Six patients with clinical and radiological diagnosis of necrotizing acute pancreatitis are treated in Emergency Surgery Department, following a conservative management, which includes fluid resuscitation, intensive care unit and radiological monitoring, ultrasound-guided percutaneous drainage and an antibiotic treatment protocol, that includes tigecycline. No one of the six patient undergo surgery (mean hospital stay: 44 days). In a six months follow-up all patients are alive and in good clinical conditions.
  
  
  CONCLUSIONS
  Infection is the most important factor which determinate prognosis and outcome of acute necrotizing pancreatitis. Antibiotic prophylaxis is still discussed and there are no clear antibiotic treatment guidelines in literature. Despite its side effects on pancreatic gland, tigecycline is successful in resolution of sepsis, caused by infected pancreatic necrosis.
  
  
  CONCLUSIONS
  Collaboration with infectivologist and a clear antibiotic protocol is fundamental to solve infected necrosis. Antibiotic treatment, set up as soon as possible, is successful in our six patients, as they recover without undergoing surgical procedures. Tigecycline offers broad coverage and efficacy against resistant pathogens for the treatment of documented pancreatic necrosis infection. However, further studies are necessary to fully understand the safety profile and efficacy of tigecycline.
authors.forename: S
authors.initials: S
authors.lastname: Occhionorelli
authors.forename: L
authors.initials: L
authors.lastname: Morganti
authors.forename: R
authors.initials: R
authors.lastname: Cultrera
authors.forename: D
authors.initials: D
authors.lastname: Andreotti
authors.forename: S
authors.initials: S
authors.lastname: Maccatrozzo
authors.forename: L
authors.initials: L
authors.lastname: Cappellari
authors.forename: R
authors.initials: R
authors.lastname: Stano
authors.forename: G
authors.initials: G
authors.lastname: Vasquez
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003287:Contrast Media; D004322:Drainage / Q000379:methods; D004636:Emergency Service, Hospital; D019160:Endosonography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis* / Q000601:surgery*; D000078304:Tigecycline; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003287:Contrast Media; D000078304:Tigecycline; D008911:Minocycline
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