title: Evaluation of Cinnamomum osmophloeum Kanehira extracts on tyrosinase suppressor, wound repair promoter, and antioxidant.
abstract: Cinnamomum osmophloeum Kanehira belongs to the Lauraceae family of Taiwan's endemic plants. In this study, C. osmophloeum Kanehira extract has shown inhibition of tyrosinase activity on B16-F10 cellular system first. Whether extracts inhibited mushroom tyrosinase activity was tested, and a considerable inhibition of mushroom tyrosinase activity by in vitro assays was presented. Animal experiments of C. osmophloeum Kanehira were carried out by observing animal wound repair, and the extracts had greater wound healing power than the vehicle control group (petroleum jelly with 8% DMSO, w/v). In addition, the antioxidant capacity of C. osmophloeum Kanehira extracts in vitro was evaluated. We measured C. osmophloeum Kanehira extract's free radical scavenging capability, metal chelating, and reduction power, such as biochemical activity analysis. The results showed that a high concentration of C. osmophloeum Kanehira extract had a significant scavenging capability of free radical, a minor effect of chelating ability, and moderate reducing power. Further exploration of the possible physiological mechanisms and the ingredient components of skincare product for skin-whitening, wound repair, or antioxidative agents are to be done.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan ; Division of Urology, Department of Surgery, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813, Taiwan.
authors.forename: Man-Gang
authors.initials: MG
authors.lastname: Lee
authors.affiliation: Department of Fragrance and Cosmetic Science, Graduate Institute of Natural Products, Center for Stem Cell Research, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
authors.forename: Su-Yu
authors.initials: SY
authors.lastname: Kuo
authors.affiliation: Department of Bioscience Technology, Chang Jung Christian University, Tainan 711, Taiwan.
authors.forename: Shih-Yu
authors.initials: SY
authors.lastname: Yen
authors.affiliation: Metal Industries Research & Development Centre, Kaohsiung 812, Taiwan.
authors.forename: Hsia-Fen
authors.initials: HF
authors.lastname: Hsu
authors.affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau.
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan ; Marine Biomedical Laboratory & Center for Translational Biopharmaceuticals, Department of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 804, Taiwan.
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: Department of Fragrance and Cosmetic Science, Graduate Institute of Natural Products, Center for Stem Cell Research, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
authors.forename: Hui-Min David
authors.initials: HM
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D027424:Cinnamomum; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D008546:Melanoma, Experimental; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D014442:Monophenol Monooxygenase
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