title: Immune Regulatory Effect of Newly Isolated Lactobacillus delbrueckii from Indian Traditional Yogurt.
abstract: Lactic acid bacteria (LAB) are microorganisms that are believed to provide health benefits. Here, we isolated LAB from Indian fermented foods, such as traditional Yogurt and Dosa. LAB from Yogurt most significantly induced TNF-α and IL-1β production, whereas LAB from Dosa induced mild cytokine production. After 16S rRNA gene sequencing and phylogenetic analysis, a Yogurt-borne lactic acid bacterium was identified and classified as Lactobacillus delbrueckii subsp. bulgaricus, and it was renamed L. delbrueckii K552 for the further studies. Our data suggest that the newly isolated L. delbrueckii can be used for the treatment of immune deficiency disorders.
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.|Skin Biotechnology Center, Gyeonggi Biocenter, Suwon 443-766, Republic of Korea.
authors.forename: Yi-Fan
authors.initials: YF
authors.lastname: Hong
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Yoon-Doo
authors.initials: YD
authors.lastname: Lee
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Jae-Yeon
authors.initials: JY
authors.lastname: Park
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Boram
authors.initials: B
authors.lastname: Jeon
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.
authors.forename: Deepa
authors.initials: D
authors.lastname: Jagdish
authors.affiliation: Institute Pasteur Korea, Seongnam 463-400, Republic of Korea.
authors.forename: Soojin
authors.initials: S
authors.lastname: Jang
authors.affiliation: Graduate School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 446-701, Republic of Korea.|Skin Biotechnology Center, Gyeonggi Biocenter, Suwon 443-766, Republic of Korea.|RNA Inc., College of Life Science, Kyung Hee University, Yongin 449-701, Republic of Korea.
authors.forename: Dae Kyun
authors.initials: DK
authors.lastname: Chung
authors.affiliation: RNA Inc., College of Life Science, Kyung Hee University, Yongin 449-701, Republic of Korea.
authors.forename: Hangeun
authors.initials: H
authors.lastname: Kim
mesh_terms: D002460:Cell Line; D016000:Cluster Analysis; D016207:Cytokines / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D006801:Humans; D056747:Immunomodulation; D048668:Lactobacillus delbrueckii / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D015014:Yogurt / Q000382:microbiology*
chemical_list: D016207:Cytokines; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S
keywords: Indian fermented foods; Interleukin-1beta; Lactic acid bacteria; Lactobacillus delbrueckii; Tumor-necrosis factor-alpha