title: Epigenetics of inflammation, maternal infection, and nutrition.
abstract: Studies have demonstrated that epigenetic changes such as DNA methylation, histone modification, and chromatin remodeling are linked to an increased inflammatory response as well as increased risk of chronic disease development. A few studies have begun to investigate whether dietary nutrients play a beneficial role by modifying or reversing epigenetically induced inflammation. Results of these studies show that nutrients modify epigenetic pathways. However, little is known about how nutrients modulate inflammation by regulating immune cell function and/or immune cell differentiation via epigenetic pathways. This overview will provide information about the current understanding of the role of nutrients in the epigenetic control mechanisms of immune function.
authors.affiliation: USDA-Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND; and kate.claycombe@ars.usda.gov.
authors.forename: Kate J
authors.initials: KJ
authors.lastname: Claycombe
authors.affiliation: Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Brissette
authors.affiliation: Department of Basic Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND.
authors.forename: Othman
authors.initials: O
authors.lastname: Ghribi
mesh_terms: D000328:Adult; D000818:Animals; D002657:Child Development; D003226:Congresses as Topic; D004032:Diet / Q000009:adverse effects*; D044127:Epigenesis, Genetic; D005260:Female; D047109:Fetal Development; D006801:Humans; D007109:Immunity; D007223:Infant; D007231:Infant, Newborn; D007774:Lactation; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
keywords: epigenetics; immunity; inflammation; macrophages; nutrients; obesity
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