title: Phospholipase A2 receptor and sarcoidosis-associated membranous nephropathy.
abstract: Of the glomerulonephritis associated with sarcoidosis, membranous nephropathy (MN) is the most prevalent. Coincidence or a causal relationship between these two diseases is unclear. Here, we present for the first time a high prevalence of PLA2R-related MN among patients with MN associated with active sarcoidosis. Our results suggest some causal link between sarcoidosis and PLA2R-related MN. Detection of anti-PLA2R antibodies in serum or PLA2R antigen in biopsy should not be taken as evidence against a secondary cause, particularly sarcoidosis. This important observation can affect treatment decision in these patients.
authors.affiliation: Service de Néphrologie et Dialyse, Necker hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Stehlé
authors.affiliation: Service de Néphrologie et Transplantation, Institut Francilien de Recherche en Néphrologie et Transplantation (IFRNT), Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris-Est Créteil (UPEC), Créteil, France INSERM U955, Equipe 21, Centre de Référence Syndrome Néphrotique Idiopathique, UPEC, Créteil, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.affiliation: INSERM unit UMR_S1155, UPMC, APHP, Tenon hospital, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Ronco
authors.affiliation: INSERM unit UMR_S1155, UPMC, APHP, Tenon hospital, Paris, France.
authors.forename: Hanna
authors.initials: H
authors.lastname: Debiec
mesh_terms: D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005260:Female; D005602:France / Q000453:epidemiology; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D054507:Receptors, Phospholipase A2 / Q000097:blood / Q000276:immunology*; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D000888:Antibodies, Anti-Idiotypic; C516360:PLA2R1 protein, human; D054507:Receptors, Phospholipase A2
keywords: membranous nephropathy; phospholipase A2 receptor; sarcoidosis