title: Gene-Environment Interplay: Where We Are, Where We Are Going.
abstract: The idea that both genetic and environmental influences contribute to behavioral outcomes is widely accepted. However, the practice of examining candidate Gene × Environment interaction (cGxE) is controversial. In this article, we summarize some of the key issues involved in cGxE research and provide recommendations for work in this area. Highlighted challenges include the selection of the gene, the development of the cGxE hypothesis, and the coding of the genotype. To address these challenges and gain confidence in cGxE findings, we recommend using empirical data to select and code genes/variants, using theory to develop cGxE hypotheses and a rigorous and transparent approach to hypothesis testing. Family researchers have much to offer to the study of Gene × Environment research in view of their process-oriented theories that are grounded in decades of nuanced measurement of the environment; implementing these best practices will help deliver on that promise.
authors.affiliation: Virginia Commonwealth University.
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Salvatore
authors.affiliation: Virginia Commonwealth University.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
keywords: developmental psychology; family research; measurement; methods; research methodologies
references.citation: Nat Genet. 2010 May;42(5):441-7
references.pmid: 20418890
references.citation: J Abnorm Psychol. 2007 Aug;116(3):554-64
references.pmid: 17696711
references.citation: Genes (Basel). 2014 Apr 10;5(2):330-46
references.pmid: 24727307
references.citation: Biol Psychiatry. 2014 Jan 1;75(1):18-24
references.pmid: 24135711
references.citation: Am J Psychiatry. 2011 Oct;168(10):1041-9
references.pmid: 21890791
references.citation: Behav Genet. 2014 Nov;44(6):578-90
references.pmid: 25195167
references.citation: PLoS One. 2012;7(4):e33575
references.pmid: 22511924
references.citation: Nicotine Tob Res. 2012 Jun;14(6):720-33
references.pmid: 22241830
references.citation: J Marriage Fam. 2015 Apr;77(2):329-343
references.pmid: 25843974
references.citation: Science. 2002 Aug 2;297(5582):851-4
references.pmid: 12161658
references.citation: Nat Rev Genet. 2009 Dec;10(12):872-8
references.pmid: 19859063
references.citation: Am J Hum Genet. 1991 Apr;48(4):677-81
references.pmid: 2014795
references.citation: J Abnorm Psychol. 2007 Feb;116(1):213-8
references.pmid: 17324032
references.citation: Perspect Psychol Sci. 2015 Jan;10(1):37-59
references.pmid: 25620996
references.citation: Arch Gen Psychiatry. 2009 Jun;66(6):640-8
references.pmid: 19487629
references.citation: J Gerontol B Psychol Sci Soc Sci. 2005 Mar;60 Spec No 1:65-76
references.pmid: 15863711
references.citation: Mol Psychiatry. 2009 Aug;14(8):746-54
references.pmid: 19455150
references.citation: Mol Psychiatry. 2014 Jan;19(1):41-9
references.pmid: 24166409
references.citation: Behav Genet. 2014 Mar;44(2):165-81
references.pmid: 24531874
references.citation: Nat Rev Genet. 2010 Apr;11(4):259-72
references.pmid: 20212493
references.citation: Alcohol Clin Exp Res. 2007 Dec;31(12):2012-9
references.pmid: 17949469
references.citation: Psychol Med. 2012 Mar;42(3):607-16
references.pmid: 21854684
references.citation: Clin Psychol Sci. 2015 Mar;3(2):189-201
references.pmid: 25821660
references.citation: Arch Gen Psychiatry. 2009 Jun;66(6):649-57
references.pmid: 19487630
references.citation: Mol Psychiatry. 2011 May;16(5):516-32
references.pmid: 20351714