title: Protective Effect of Hydroxytyrosol Against Cardiac Remodeling After Isoproterenol-Induced Myocardial Infarction in Rat.
abstract: The present study aimed to investigate the cardioprotective effect of hydroxytyrosol (HT) against isoproterenol-induced myocardial infarction in rats. Male rats were randomly divided into four groups, control, isoproterenol (Isop) and pretreated animals with HT in two different doses (2 and 5 mg/kg) orally for 7 days and intoxicated with isoproterenol (Isop + HT1) and (Isop + HT2) groups. Myocardial infarction in rats was induced subcutaneously by isoproterenol (100 mg/kg, s.c.) at an interval of 24 h on 6th and 7th day. On 8th day, electrocardiographic (ECG) pattern, gravimetric and biochemical parameters were assessed. Isoproterenol exhibited changes in ECG pattern, including significant ST-segment elevation and increase in the serum troponin-T level by 317 % as compared to control rats. Moreover, cardiac injury markers (creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase) underwent a notable rise in serum of infarcted animals. Else, a disturbance in lipids profile and significant increase in lipase and angiotensin-converting enzyme (ACE) activities and heart weight ratio were observed in isoproterenol group. However, pre- and co-treatment with HT (2 and 5 mg/kg) improved the myocardium injury, restored the hemodynamic function and inhibited the ACE activity that prevent cardiac hypertrophy and remodeling. Overall, these findings demonstrated that HT exerted a potent cardioprotective effect against isoproterenol-induced myocardial infarction.
authors.affiliation: Laboratory of Animal Physiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, 3052, Sfax, Tunisia. mnafgui_kais@yahoo.fr.|Department of Internal Medicine, Hospital of Sidi Bouzid, 9100, Sidi Bouzid, Tunisia. mnafgui_kais@yahoo.fr.
authors.forename: Kais
authors.initials: K
authors.lastname: Mnafgui
authors.affiliation: Department of Internal Medicine, Hospital of Sidi Bouzid, 9100, Sidi Bouzid, Tunisia.
authors.forename: Raouf
authors.initials: R
authors.lastname: Hajji
authors.affiliation: Department of Internal Medicine, Hospital of Sidi Bouzid, 9100, Sidi Bouzid, Tunisia.
authors.forename: Fatma
authors.initials: F
authors.lastname: Derbali
authors.affiliation: Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
authors.forename: Ines
authors.initials: I
authors.lastname: Khlif
authors.affiliation: Faculty of Medicine of Monastir, Avenue Avicenne, 5019, Monastir, Tunisia.
authors.forename: Ftouma
authors.initials: F
authors.lastname: Kraiem
authors.affiliation: Department of Cardiology, Centre Hospitalier Intercommunal Robert Ballanger, 93600, Boulevard Robert Ballanger, Aulnay-Sous-Bois, France.
authors.forename: Hedi
authors.initials: H
authors.lastname: Ellefi
authors.affiliation: Laboratory of Animal Physiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, 3052, Sfax, Tunisia.
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: Elfeki
authors.affiliation: Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Allouche
authors.affiliation: Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, University of Sfax, B.P. 1171, 3000, Sfax, Tunisia.
authors.forename: Neji
authors.initials: N
authors.lastname: Gharsallah
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007545:Isoproterenol / Q000633:toxicity*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
chemical_list: D002316:Cardiotonic Agents; C005975:3,4-dihydroxyphenylethanol; D007545:Isoproterenol; D010626:Phenylethyl Alcohol
keywords: ACE; ECG; Hydroxytyrosol; Myocardial infarction; Troponin-T