title: Merger of visible light induced oxidation and enantioselective alkylation with a chiral iridium catalyst.
abstract: A single chiral octahedral iridium(III) complex is used for visible light activated asymmetric photoredox catalysis. In the presence of a conventional household lamp and under an atmosphere of air, the oxidative coupling of 2-acyl-1-phenylimidazoles with N,N-diaryl-N-(trimethylsilyl)methylamines provides aminoalkylated products in 61-93 % yields with high enantiomeric excess (90-98 % ee). Notably, the iridium center simultaneously serves three distinct functions: as the exclusive source of chirality, as the catalytically active Lewis acid, and as a central part of the photoredox sensitizer. This conceptionally simple reaction Scheme may provide new avenues for the green synthesis of non-racemic chiral molecules.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35043 Marburg (Germany).
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zheng
authors.forename: Haohua
authors.initials: H
authors.lastname: Huo
authors.forename: Philipp
authors.initials: P
authors.lastname: Röse
authors.forename: Lilu
authors.initials: L
authors.lastname: Zhang
authors.forename: Klaus
authors.initials: K
authors.lastname: Harms
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hilt
authors.forename: Eric
authors.initials: E
authors.lastname: Meggers
keywords: asymmetric catalysis; iridium; metal-centered chirality; photoredox catalysis; visible light