title: Microbiota and mucosal immunity in amphibians.
abstract: We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small-animal model to improve the fundamental knowledge on immunological functions of gut microbiota.
authors.affiliation: Institute of Systems and Synthetic Biology, Université d'Evry Val d'Essonne , Evry , France.
authors.forename: Bruno M
authors.initials: BM
authors.lastname: Colombo
authors.affiliation: Institute of Systems and Synthetic Biology, Université d'Evry Val d'Essonne , Evry , France.
authors.forename: Thibault
authors.initials: T
authors.lastname: Scalvenzi
authors.affiliation: Institute of Systems and Synthetic Biology, Université d'Evry Val d'Essonne , Evry , France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Benlamara
authors.affiliation: Institute of Systems and Synthetic Biology, CNRS , Evry , France ; Evolution, Genome, Comportement et Ecologie, CNRS, Université Paris-Sud, IRD , Gif-sur-Yvette , France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pollet
keywords: Xenopus; chytrid; microbiome; mucosal immunity; small-animal model
references.citation: Int Immunol. 1999 Apr;11(4):499-508
references.pmid: 10323202
references.citation: Biopolymers. 1998;47(6):435-50
references.pmid: 10333736
references.citation: Dev Comp Immunol. 1999 Sep;23(6):473-85
references.pmid: 10512458
references.citation: Development. 2000 Jan;127(2):381-92
references.pmid: 10603354
references.citation: Eur J Immunol. 2000 Feb;30(2):604-13
references.pmid: 10671217
references.citation: Science. 2000 Apr 14;288(5464):287-93
references.pmid: 10777411
references.citation: Immunol Rev. 2000 Jun;175:201-13
references.pmid: 10933604
references.citation: Dev Comp Immunol. 2001 May;25(4):323-36
references.pmid: 11246072
references.citation: Cell Tissue Res. 2001 Oct;306(1):35-47
references.pmid: 11683180
references.citation: J Immunol. 2002 Jan 1;168(1):57-64
references.pmid: 11751946
references.citation: Nature. 2003 Mar 13;422(6928):164-9
references.pmid: 12634786
references.citation: Ann N Y Acad Sci. 2003 Apr;987:15-25
references.pmid: 12727620
references.citation: Nat Rev Immunol. 2004 Jun;4(6):469-78
references.pmid: 15173835
references.citation: Physiol Biochem Zool. 2005 Mar-Apr;78(2):201-15
references.pmid: 15778940
references.citation: J Exp Zool A Comp Exp Biol. 2005 Aug 1;303(8):704-12
references.pmid: 16013051
references.citation: Comp Biochem Physiol C Toxicol Pharmacol. 2006 Jan-Feb;142(1-2):46-52
references.pmid: 16309969
references.citation: J Invest Dermatol. 2006 Jan;126(1):25-31
references.pmid: 16417214
references.citation: J Immunol. 2006 Feb 1;176(3):1618-27
references.pmid: 16424191
references.citation: Nat Rev Immunol. 2006 Mar;6(3):205-17
references.pmid: 16498451
references.citation: Annu Rev Immunol. 2006;24:497-518
references.pmid: 16551257
references.citation: Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12087-92
references.pmid: 16877547
references.citation: Dev Comp Immunol. 2007;31(4):383-93
references.pmid: 16926047
references.citation: Eur J Immunol. 2007 Jun;37(6):1494-501
references.pmid: 17492621
references.citation: Appl Environ Microbiol. 2007 Aug;73(16):5261-7
references.pmid: 17586664
references.citation: ILAR J. 2007;48(3):183-7
references.pmid: 17592182
references.citation: Nat Rev Immunol. 2007 Aug;7(8):645-50
references.pmid: 17641664
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D761-7
references.pmid: 17984085
references.citation: Clin Infect Dis. 2008 Feb 1;46 Suppl 2:S80-6; discussion S144-51
references.pmid: 18181729
references.citation: Immunogenetics. 2008 Feb;60(2):105-14
references.pmid: 18214467
references.citation: Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
references.pmid: 18936492
references.citation: Biochemistry. 1991 Sep 10;30(36):8824-30
references.pmid: 1909573
references.citation: Dev Dyn. 2009 Jun;238(6):1249-70
references.pmid: 19253402
references.citation: ISME J. 2009 Jul;3(7):818-24
references.pmid: 19322245
references.citation: Cell Mol Life Sci. 2009 Aug;66(16):2603-22
references.pmid: 19390784
references.citation: Development. 2009 Jul;136(14):2323-7
references.pmid: 19515697
references.citation: Trends Immunol. 2009 Jul;30(7):374-81
references.pmid: 19541538
references.citation: Mucosal Immunol. 2009 Nov;2(6):478-85
references.pmid: 19741595
references.citation: Science. 2009 Oct 23;326(5952):582-5
references.pmid: 19900897
references.citation: Front Biosci (Landmark Ed). 2010 Jan 01;15:348-58
references.pmid: 20036824
references.citation: PLoS Pathog. 2010 Jan 29;6(1):e1000550
references.pmid: 20126439
references.citation: Zoolog Sci. 2010 Feb;27(2):154-61
references.pmid: 20141420
references.citation: Science. 2010 Apr 30;328(5978):633-6
references.pmid: 20431018
references.citation: Genome Biol. 2010;11(5):R55
references.pmid: 20482879
references.citation: Infect Immun. 2010 Sep;78(9):3981-92
references.pmid: 20584973
references.citation: Nat Immunol. 2010 Sep;11(9):827-35
references.pmid: 20676094
references.citation: Curr Gastroenterol Rep. 2010 Oct;12(5):319-30
references.pmid: 20703838
references.citation: J Anim Sci. 2011 May;89(5):1531-7
references.pmid: 20833767
references.citation: Trends Immunol. 2010 Nov;31(11):422-8
references.pmid: 20951645
references.citation: Adv Immunol. 2010;107:71-107
references.pmid: 21034971
references.citation: Dev Comp Immunol. 2011 Mar;35(3):366-77
references.pmid: 21075137
references.citation: Nat Immunol. 2011 Jan;12(1):21-7
references.pmid: 21113163
references.citation: Dis Model Mech. 2011 Mar;4(2):179-92
references.pmid: 21183475
references.citation: Science. 2010 Dec 24;330(6012):1768-73
references.pmid: 21205662
references.citation: Curr Opin Microbiol. 2011 Feb;14(1):106-14
references.pmid: 21215684
references.citation: Dev Immunol. 1990;1(2):85-95
references.pmid: 2136209
references.citation: ISME J. 2011 Oct;5(10):1595-608
references.pmid: 21472014
references.citation: Immunol Rev. 2011 May;241(1):241-59
references.pmid: 21488901
references.citation: Integr Comp Biol. 2011 Oct;51(4):552-62
references.pmid: 21816807
references.citation: Gut Microbes. 2011 May-Jun;2(3):193-7
references.pmid: 21869608
references.citation: Cell Metab. 2011 Sep 7;14(3):403-14
references.pmid: 21907145
references.citation: ISME J. 2012 Mar;6(3):588-96
references.pmid: 21955991
references.citation: Trends Genet. 2011 Dec;27(12):507-15
references.pmid: 21963197
references.citation: Cell Host Microbe. 2011 Oct 20;10(4):311-23
references.pmid: 22018232
references.citation: Trends Immunol. 2012 Jan;33(1):42-8
references.pmid: 22079120
references.citation: Vet Immunol Immunopathol. 2012 Jan 15;145(1-2):493-8
references.pmid: 22100190
references.citation: Ecohealth. 2011 Dec;8(4):501-6
references.pmid: 22328095
references.citation: Dis Aquat Organ. 2012 Feb 17;98(1):11-25
references.pmid: 22422126
references.citation: Front Immunol. 2012 Mar;3(March):19
references.pmid: 22448160
references.citation: Science. 2012 Jun 8;336(6086):1321-5
references.pmid: 22674331
references.citation: Nature. 2012 May 09;486(7402):222-7
references.pmid: 22699611
references.citation: Mucosal Immunol. 2013 Mar;6(2):358-68
references.pmid: 22929561
references.citation: Nature. 2012 Sep 13;489(7415):231-41
references.pmid: 22972296
references.citation: Cell Host Microbe. 2012 Sep 13;12(3):277-88
references.pmid: 22980325
references.citation: Dev Dyn. 2013 Feb;242(2):164-78
references.pmid: 23172757
references.citation: Nat Rev Immunol. 2013 Feb;13(2):75-87
references.pmid: 23292121
references.citation: Genome Biol. 2013 Jan 24;14(1):R4
references.pmid: 23347395
references.citation: Dev Comp Immunol. 1990 Winter;14(1):69-84
references.pmid: 2338158
references.citation: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3229-36
references.pmid: 23391737
references.citation: Ecol Lett. 2013 Jun;16(6):807-20
references.pmid: 23452227
references.citation: Cold Spring Harb Perspect Med. 2013 Mar 01;3(3):a010074
references.pmid: 23457295
references.citation: Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61
references.pmid: 23478383
references.citation: J Innate Immun. 2013;5(6):531-42
references.pmid: 23485675
references.citation: Genes Dev. 2013 Apr 1;27(7):701-18
references.pmid: 23592793
references.citation: Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14342-7
references.pmid: 23940320
references.citation: Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15325-9
references.pmid: 24003137
references.citation: Mol Ecol. 2014 Mar;23(6):1238-50
references.pmid: 24171949
references.citation: Semin Immunol. 2013 Nov 30;25(5):352-7
references.pmid: 24184013
references.citation: Zoolog Sci. 2013 Nov;30(11):938-43
references.pmid: 24199859
references.citation: Environ Microbiol Rep. 2013 Dec;5(6):899-903
references.pmid: 24249298
references.citation: PLoS One. 2013 Nov 20;8(11):e80477
references.pmid: 24278286
references.citation: ISME J. 2014 Apr;8(4):830-40
references.pmid: 24335825
references.citation: Front Immunol. 2013 Dec 12;4:445
references.pmid: 24376446
references.citation: Inflamm Bowel Dis. 2014 Mar;20(3):417-30
references.pmid: 24418903
references.citation: PLoS One. 2014 Apr 30;9(4):e96375
references.pmid: 24789229
references.citation: Immunogenetics. 2014 Oct;66(9-10):513-23
references.pmid: 24898512
references.citation: Annu Rev Immunol. 1989;7:251-75
references.pmid: 2653371
references.citation: Conserv Physiol. 2014 Apr 21;2(1):cou012
references.pmid: 27293633
references.citation: J Immunol. 1989 Jan 1;142(1):41-7
references.pmid: 2783326
references.citation: J Immunol. 1986 Dec 15;137(12):3891-9
references.pmid: 3537126
references.citation: J Morphol. 1972 Dec;138(4):487-97
references.pmid: 4638093
references.citation: J Embryol Exp Morphol. 1969 Sep;22(2):265-77
references.pmid: 5361557
references.citation: Experientia. 1967 Nov 15;23(11):950-1
references.pmid: 6057023
references.citation: J Anat. 1978 Feb;125(Pt 2):237-45
references.pmid: 624675
references.citation: J Anat. 1978 Jan;125(Pt 1):155-69
references.pmid: 632211
references.citation: J Anat. 1978 May;126(Pt 1):133-44
references.pmid: 649494
references.citation: Appl Environ Microbiol. 1983 Dec;46(6):1423-5
references.pmid: 6607034
references.citation: Dev Biol. 1982 Apr;90(2):253-8
references.pmid: 7042416
references.citation: J Morphol. 1982 Jul;173(1):35-41
references.pmid: 7108967
references.citation: J Immunol. 1980 Dec;125(6):2626-32
references.pmid: 7430642
references.citation: J Biol Chem. 1994 Apr 8;269(14):10849-55
references.pmid: 8144672
references.citation: J Histochem Cytochem. 1994 Jun;42(6):697-704
references.pmid: 8189032
references.citation: J Exp Zool. 1995 Dec 15;273(6):451-60
references.pmid: 8568500
references.citation: Dev Comp Immunol. 1995 Nov-Dec;19(6):507-23
references.pmid: 8773200
references.citation: Eur J Immunol. 1996 Dec;26(12):2823-30
references.pmid: 8977274
references.citation: Dev Immunol. 1997;5(2):133-44
references.pmid: 9587714
references.citation: Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9031-6
references.pmid: 9671799
references.citation: Dev Dyn. 1998 Aug;212(4):509-21
references.pmid: 9707324
references.citation: Eur J Immunol. 1998 Sep;28(9):2947-59
references.pmid: 9754582
references.citation: Gastroenterology. 1998 Dec;115(6):1414-25
references.pmid: 9834269
references.citation: Dev Comp Immunol. 1998 Sep-Dec;22(5-6):605-12
references.pmid: 9877440
references.citation: Immunol Rev. 1998 Dec;166:221-30
references.pmid: 9914915