title: Effect of the route of administration on the mucosal and systemic immune responses to Lawsonia intracellularis vaccine in pigs.
abstract: In an on-farm study, 40 weaned piglets aged 3 weeks were vaccinated with Lawsonia intracellularis vaccine orally, IM or IP while a fourth group remained unvaccinated. All vaccinated animals showed increased serum levels of L. intracellularis-specific IgG antibodies, but significantly elevated concentrations of specific IgG, IgA and cytokines were generated in ileal mucosal secretions from the orally and IP vaccinated pigs when examined at 17 days after vaccination.
authors.affiliation: Farm Animal and Veterinary Public Health, University of Sydney, Camden, New South Wales, Australia.
authors.forename: M G
authors.initials: MG
authors.lastname: Nogueira
authors.forename: A M
authors.initials: AM
authors.lastname: Collins
authors.forename: R H
authors.initials: RH
authors.lastname: Dunlop
authors.forename: D
authors.initials: D
authors.lastname: Emery
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology / Q000627:therapeutic use*; D045824:Desulfovibrionaceae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D020639:Lawsonia Bacteria / Q000276:immunology*; D009061:Mouth Mucosa / Q000276:immunology / Q000378:metabolism*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D015850:Interleukin-6; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: Lawsonia intracellularis; immunity; pigs; vaccination