title: [Fecal microbiota transplantation in recurrent Clostridium difficile infections. Framework and pharmaceutical preparation aspects].
abstract: The fecal microbiota transplantation consists in introducing a preparation constituted by a dilution of stools of a healthy donor in the digestive tract of a patient recipient, to restore his intestinal physiological balance. This therapeutic approach was the subject of numerous studies showing its efficiency in the treatment of the recurrent infections with Clostridium difficile. The fecal microbiota transplantation has now a high level of clinical evidence, which explains that it appears in various international recommendations. In France, the fecal microbiota transplantation responds to the definition of a medication and can be executed as a pharmaceutical preparation or as an experimental drug for clinical trials under the responsibility of a hospital pharmacy. The objective of this paper is to propose a definition of a framework and to describe the methods of preparation of the fecal microbiota transplantation in the treatment of the recurrent infections with C. difficile and the interactions to consider for hospital pharmacies that do not have technical means to operate this technique.
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address: rui.batista@cch.aphp.fr.
authors.forename: R
authors.initials: R
authors.lastname: Batista
authors.affiliation: Laboratoire de coprologie fonctionnelle, GH Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75652 Paris cedex 13, France.
authors.forename: N
authors.initials: N
authors.lastname: Kapel
authors.affiliation: Droit et économie de la santé, faculté des sciences pharmaceutiques et biologiques Paris Descartes, université Paris Descartes, 4, avenue de l'Observatoire, 75270 Paris cedex 06, France.
authors.forename: F
authors.initials: F
authors.lastname: Megerlin
authors.affiliation: Laboratoire de pharmacie galénique, faculté des sciences pharmaceutiques et biologiques Paris Descartes, université Paris Descartes, 4, avenue de l'Observatoire, 75270 Paris cedex 06, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Chaumeil
authors.affiliation: Laboratoire Clostridium difficile associé au CNR des bactéries anaérobies, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France.
authors.forename: F
authors.initials: F
authors.lastname: Barbut
authors.affiliation: Académie nationale de pharmacie, 4, avenue de l'Observatoire, 75270 Paris cedex 06, France.
authors.forename: P
authors.initials: P
authors.lastname: Bourlioux
authors.affiliation: Service de pharmacie clinique, hôpitaux universitaires Paris-Centre, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France.
authors.forename: F
authors.initials: F
authors.lastname: Chast
mesh_terms: D016360:Clostridioides difficile; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy*; D000069467:Fecal Microbiota Transplantation / Q000379:methods*; D006801:Humans; D064307:Microbiota
keywords: Clostridium difficile infection; Fecal microbiota transplantation; Flora transplantation; Infection à Clostridium difficile; Medication; Médicament; Transfert de flore; Transfert de microbiote fécal