title: Circuit resistance training attenuates acute exertion-induced reductions in arterial function but not inflammation in obese women.
abstract: BACKGROUND
  Cardiovascular disease (CVD) is a leading cause of preventable death among young women in the United States. Habitual resistance exercise training is known to have beneficial effects on endothelial function and CVD risk factors, including obesity; however, previous studies show that acute resistance exercise impairs endothelial function in obese adults who are sedentary, a response that may be linked to inflammation. We sought to determine if circuit-based resistance training (CRT) attenuates acute resistance exercise-induced reductions in endothelial function in a population of young, obese, sedentary women and whether or not inflammation plays a role in this response.
  
  
  METHODS
  Eighteen obese [body mass index (BMI) 30.0-40.0 kg · m(-2)] young premenopausal women were randomly assigned to either a CRT group or a no-exercise control group (CON). Conduit artery endothelial function was assessed using brachial artery flow-mediated dilation (FMD) determined by ultrasound before and after a single bout of strenuous weightlifting (SWL). In addition, circulating inflammatory mediators (tumor necrosis factor-α and C-reactive protein), blood pressure, fasting blood lipids, glucose, waist circumference, body composition, and aerobic capacity were assessed.
  
  
  RESULTS
  Among participants randomized to the CRT group, 8 weeks of training led to considerable increases in FMD after SWL (P=0.001) compared to the CON group. However, no significant differences between the groups were observed in circulating inflammatory mediators, blood pressure, fasting blood lipids, or other physical and physiological characteristics.
  
  
  CONCLUSIONS
  This study shows that CRT alleviates acute exertion-induced reductions in endothelial function among obese sedentary women in the absence of changes in inflammation.
authors.affiliation: 1 Department of Physical Therapy, University of Illinois at Chicago , Chicago, Illinois.
authors.forename: Nina C
authors.initials: NC
authors.lastname: Franklin
authors.forename: Austin T
authors.initials: AT
authors.lastname: Robinson
authors.forename: Jing-Tan
authors.initials: JT
authors.lastname: Bian
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Ali
authors.forename: Edita
authors.initials: E
authors.lastname: Norkeviciute
authors.forename: Patrick
authors.initials: P
authors.lastname: McGinty
authors.forename: Shane A
authors.initials: SA
authors.lastname: Phillips
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000737:chemistry; D001794:Blood Pressure; D001823:Body Composition; D015992:Body Mass Index; D001835:Body Weight; D001916:Brachial Artery / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D005082:Physical Exertion; D017697:Premenopause; D055070:Resistance Training; D012307:Risk Factors; D057185:Sedentary Behavior; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014665:Vasodilator Agents / Q000627:therapeutic use; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D014665:Vasodilator Agents; D002097:C-Reactive Protein
references.citation: Biomed Res Int. 2014;2014:327395
references.pmid: 24772421
references.citation: J Appl Physiol (1985). 2011 Apr;110(4):1013-20
references.pmid: 21252216
references.citation: Med Sci Sports Exerc. 2003 Jul;35(7):1139-45
references.pmid: 12840634
references.citation: Obesity (Silver Spring). 2010 Aug;18(8):1667-9
references.pmid: 20057377
references.citation: Front Physiol. 2014 Jul 07;5:253
references.pmid: 25071598
references.citation: Med Sci Sports Exerc. 2006 Sep;38(9):1558-64
references.pmid: 16960515
references.citation: J Appl Physiol (1985). 2013 Dec;115(11):1589-98
references.pmid: 24030665
references.citation: Circulation. 1999 Sep 14;100(11):1194-202
references.pmid: 10484540
references.citation: Circulation. 2004 Jun 1;109(21 Suppl 1):II27-33
references.pmid: 15173060
references.citation: BMC Public Health. 2012;12:704
references.pmid: 23006411
references.citation: Eval Health Prof. 2007 Jun;30(2):138-49
references.pmid: 17476027
references.citation: J Am Coll Cardiol. 1994 Nov 15;24(6):1468-74
references.pmid: 7930277
references.citation: Hypertension. 2009 Aug;54(2):278-85
references.pmid: 19546374
references.citation: J Physiol. 2004 Nov 15;561(Pt 1):1-25
references.pmid: 15375191
references.citation: Int J Obes (Lond). 2008 May;32(5):826-31
references.pmid: 18197180
references.citation: Arterioscler Thromb Vasc Biol. 2005 Apr;25(4):809-14
references.pmid: 15692095
references.citation: J Am Coll Cardiol. 2006 Aug 1;48(3):588-9
references.pmid: 16875990
references.citation: PLoS One. 2013;8(10):e78350
references.pmid: 24205208
references.citation: Nutr J. 2011;10:8
references.pmid: 21251283
references.citation: Sports Med. 2001;31(14):953-64
references.pmid: 11735680
references.citation: Med Sci Sports Exerc. 2007 Dec;39(12):2242-7
references.pmid: 18046197
references.citation: J Strength Cond Res. 2006 Aug;20(3):584-92
references.pmid: 16937972
references.citation: Pflugers Arch. 2010 May;459(6):923-39
references.pmid: 20306272
references.citation: Med Sci Sports Exerc. 2004 May;36(5):772-9
references.pmid: 15126709
references.citation: Circulation. 1995 Dec 15;92(12):3431-5
references.pmid: 8521564
references.citation: Hypertens Res. 2000 May;23(3):233-8
references.pmid: 10821132
references.citation: J Strength Cond Res. 2004 Nov;18(4):760-4
references.pmid: 15574103
references.citation: Med Sci Monit. 2013;19:949-53
references.pmid: 24196521
references.citation: Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1797-802
references.pmid: 16648182
references.citation: Int J Obes Relat Metab Disord. 2000 Apr;24(4):497-501
references.pmid: 10805508
references.citation: Cardiovasc J S Afr. 2005 Sep-Oct;16(5):256-9
references.pmid: 16307157
references.citation: Lipids Health Dis. 2010;9:82
references.pmid: 20684772
references.citation: Acta Physiol (Oxf). 2012 Jul;205(3):394-402
references.pmid: 22276926
references.citation: Arch Phys Med Rehabil. 2014 Jun;95(6):1127-34
references.pmid: 24583315
references.citation: Atherosclerosis. 2009 Nov;207(1):220-6
references.pmid: 19410255
references.citation: Biochemistry (Mosc). 1998 Jul;63(7):810-6
references.pmid: 9721333
references.citation: J Am Coll Cardiol. 2002 Jan 16;39(2):257-65
references.pmid: 11788217
references.citation: Acta Physiol (Oxf). 2009 Jun;196(2):193-222
references.pmid: 19220204
references.citation: Obesity (Silver Spring). 2008 Mar;16(3):578-84
references.pmid: 18239561
references.citation: Circulation. 1997 Oct 7;96(7):2468-82
references.pmid: 9337227
references.citation: J Am Coll Cardiol. 2004 May 19;43(10):1823-7
references.pmid: 15145107
references.citation: J Appl Physiol (1985). 2004 Aug;97(2):499-508
references.pmid: 15064302
references.citation: Am J Med Sci. 1999 May;317(5):295-300
references.pmid: 10334116
references.citation: J Strength Cond Res. 2006 Nov;20(4):838-42
references.pmid: 17194251
references.citation: Appl Physiol Nutr Metab. 2010 Apr;35(2):163-71
references.pmid: 20383226
references.citation: J Appl Physiol (1985). 2008 Mar;104(3):588-600
references.pmid: 18063803