title: Intraocular pressure control with echothiophate iodide in children's eyes with glaucoma after cataract extraction.
abstract: OBJECTIVE
  To report the intraocular pressure (IOP)-lowering ability and side-effect profile of echothiophate iodide (EI) in the control of glaucoma in aphakic and pseudophakic eyes of children.
  
  
  METHODS
  The medical records of all aphakic and pseudophakic children treated with EI for IOP lowering after developing glaucoma were retrospectively reviewed.
  
  
  RESULTS
  A total of 32 eyes of 21 children were included. Mean age at cataract removal was 3.9 months (range, 5 days-2.7 years). Mean age of glaucoma diagnosis was 3.2 years (range, 40 days-12 years). Mean duration from cataract removal and diagnosis of glaucoma was 2.9 years (range, 16 days-12 years). EI reduced IOP in 31 of 32 eyes. Mean baseline IOP (29.1 ± 5.3 mm Hg) dropped to 19.6 ± 6.7 mm Hg. Six eyes had IOP spikes that could not be controlled with other medications when commercial unavailability led to discontinuation of EI. Average duration of use was 3.5 years. Mean final IOP on an average of 2.2 medications was 16.9 ± 5.1 mm Hg 7.9 years following initial glaucoma diagnosis. Four eyes required surgery for uncontrolled IOP. Side-effects included transient redness (3/32 eyes), not necessitating discontinuation of EI.
  
  
  CONCLUSIONS
  EI lowered IOP to within an acceptable range with no significant adverse events. In several patients it was the only pharmacologic agent that was successful.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
authors.forename: Courtney L
authors.initials: CL
authors.lastname: Kraus
authors.affiliation: Miles Center for Pediatric Ophthalmology, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Rupal H
authors.initials: RH
authors.lastname: Trivedi
authors.affiliation: Miles Center for Pediatric Ophthalmology, Storm Eye Institute, Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina. Electronic address: wilsonme@musc.edu.
authors.forename: M Edward
authors.initials: ME
authors.lastname: Wilson
mesh_terms: D001036:Aphakia, Postcataract / Q000209:etiology; D002386:Cataract / Q000151:congenital; D002387:Cataract Extraction; D002648:Child; D002675:Child, Preschool; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D004456:Echothiophate Iodide / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D019591:Pseudophakia / Q000209:etiology; D012189:Retrospective Studies; D014065:Tonometry, Ocular
chemical_list: D002800:Cholinesterase Inhibitors; D004456:Echothiophate Iodide