title: Modulation of pre-attentive spectro-temporal feature processing in the human auditory system by HD-tDCS.
abstract: The present study examined the functional lateralization of the human auditory cortex (AC) for pre-attentive spectro-temporal feature processing. By using high-definition transcranial direct current stimulation (HD-tDCS), we systematically modulated neuronal activity of the bilateral AC. We assessed the influence of anodal and cathodal HD-tDCS delivered over the left or right AC on auditory mismatch negativity (MMN) in response to temporal as well as spectral deviants in 12 healthy subjects. The results showed that MMN to temporal deviants was significantly enhanced by anodal HD-tDCS applied over the left AC only. Our data indicate a left hemispheric dominance for the pre-attentive processing of low-level temporal information.
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
authors.forename: Kai
authors.initials: K
authors.lastname: Heimrath
authors.affiliation: Department of Child and Adolescent Psychiatry, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
authors.forename: Carolin
authors.initials: C
authors.lastname: Breitling
authors.affiliation: Department of Child and Adolescent Psychiatry, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.|Center for Behavioral Brain Sciences, Magdeburg, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Krauel
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.|Center for Behavioral Brain Sciences, Magdeburg, Germany.
authors.forename: Hans-Jochen
authors.initials: HJ
authors.lastname: Heinze
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
authors.forename: Tino
authors.initials: T
authors.lastname: Zaehle
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000502:physiology*; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology*; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D065908:Transcranial Direct Current Stimulation; D055815:Young Adult
keywords: HD-tDCS; MMN; auditory cortex; auditory spectro-temporal perception; hemispheric lateralization