title: Prognostic significance of MYH9 expression in resected non-small cell lung cancer.
abstract: BACKGROUND
  Myosin-9 (MYH9) belongs to the myosin superfamily of actin-binding motor protein. Recently, MYH9 has been thought to be associated with cancer cell migration, invasion, and metastasis. The aims of this study were to immunohistochemically examine MYH9 expression in surgically resected non-small cell lung cancer (NSCLC), and evaluate its correlations with clinicopathological parameters and the prognosis of patients.
  
  
  METHODS
  MYH9 expression was immunohistochemically studied in 266 consecutive resected NSCLCs, and its associations with clinicopathological parameters were evaluated. Kaplan-Meier survival analysis and Cox proportional hazards models were used to estimate the effect of MYH9 expression on survival.
  
  
  RESULTS
  MYH9 expression was detected in 102 of 266 (38.3%) NSCLCs. MYH9 expression was significantly correlated with the adenocarcinoma histology (P = 0.014), poorer differentiation ((P = 0.033), intratumoral vascular invasion and lymphatic invasion ((P = 0.013 and P = 0.045 respectively), and a poorer prognosis ((P = 0.032). In addition, multivariable analysis revealed that MYH9 expression independently predicted a poorer survival (HR, 2.15; 95%CI, 1.17-3.92; (P = 0.01).
  
  
  CONCLUSIONS
  The present study revealed that MYH9 is expressed in a subset of NSCLC with a more malignant nature, and its expression is an indicator of a poorer survival probability.
authors.affiliation: Department of Respiratory Medicine, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Katono
authors.affiliation: Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Pathology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Shi-Xu
authors.initials: SX
authors.lastname: Jiang
authors.affiliation: Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Kanagawa, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Nagashio
authors.affiliation: Department of Respiratory Medicine, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Ryuge
authors.affiliation: Division of Quantitative Proteomics Team, Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Fukuda
authors.affiliation: Division of Quantitative Proteomics Team, Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Goshima
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Satoh
authors.affiliation: Department of Pathology, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Saegusa
authors.affiliation: Department of Respiratory Medicine, School of Medicine, Kitasato University, Kanagawa, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Masuda
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D020409:Molecular Motor Proteins / Q000235:genetics*; D018995:Myosin Heavy Chains / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate
chemical_list: C103814:MYH9 protein, human; D020409:Molecular Motor Proteins; D018995:Myosin Heavy Chains
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