title: Role of intravenous iron sucrose in correction of anemia in antenatal women with advanced pregnancy.
abstract: The aim of this study is to observe rise in haematological parameters after treatment with iron sucrose in antenatal patients with moderate anemia with period of gestation 32 to 35 weeks. The study included 45 antenatal patients with period of gestation from 32 to 35 weeks having iron deficiency anemia with haemoglobin levels 7-9 g% and serum ferritin levels less than 12 ng/mL. Intravenous iron sucrose was given in the dose of 200 mg on alternate days, according to the calculated dose. The mean haemoglobin and red blood cell indices were compared on days 7, 14, 21, 28 and at the time of delivery from the baseline value. There was a statistically significant rise in haemoglobin value from baseline on days 14, 21, 28 as well as at the time of delivery (p value <0.0001). The mean rise in haemoglobin values was 0.56 g% on day 14, 1.44 g% on day 21 and 2.0 g% on day 28. At the time of delivery, mean haemoglobin was 11.24 g%. After 28 days of treatment, there was a statistically significant rise in the levels of serum ferritin from 10.33 ± 3.8 ng/mL to 36.89 ± 5.7 ng/mL. Thus, earlier response achieved by iron sucrose can be utilised in the patients presenting at an advanced period of gestation with iron deficiency anemia.
authors.affiliation: Department of Obstetrics & Gynaecology, Maulana Azad Medical College, House no. 93-94, Pocket 2, Sector 22, Rohini, New Delhi, 110086 India.
authors.forename: Avantika
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics & Gynaecology, Maulana Azad Medical College, New Delhi, India.
authors.forename: Asmita Muthal
authors.initials: AM
authors.lastname: Rathore
authors.affiliation: Department of Obstetrics & Gynaecology, Maulana Azad Medical College, New Delhi, India.
authors.forename: Usha
authors.initials: U
authors.lastname: Manaktala
authors.affiliation: Department of Medicine, Sarojini Naidu Medical College, Agra, India.
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics & Gynaecology, Maulana Azad Medical College, New Delhi, India.
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Gupta
keywords: Blood transfusion; Pregnancy near term; Side effects
references.citation: Am J Kidney Dis. 2002 Dec;40(6):1111-21
references.pmid: 12460028
references.citation: Indian J Hematol Blood Transfus. 2014 Jun;30(2):120-5
references.pmid: 24839366
references.citation: Am J Obstet Gynecol. 2002 Mar;186(3):518-22
references.pmid: 11904617
references.citation: J Obstet Gynaecol Res. 2013 Feb;39(2):504-10
references.pmid: 22925176
references.citation: ANNA J. 1999 Oct;26(5):522-4
references.pmid: 10776081
references.citation: Obstet Gynecol. 2005 Dec;106(6):1335-40
references.pmid: 16319260
references.citation: Indian J Med Res. 2013;138:16-7
references.pmid: 24056552
references.citation: Am J Hematol. 2004 May;76(1):74-8
references.pmid: 15114602
references.citation: Br J Haematol. 2012 Mar;156(5):588-600
references.pmid: 22512001
references.citation: Indian J Med Res. 2013;138:78-82
references.pmid: 24056559
references.citation: BMJ. 2013 Aug 15;347:f4822
references.pmid: 23950195