title: Glottic and supraglottic pT3 squamous cell carcinoma: outcomes with transoral laser microsurgery.
abstract: Patients diagnosed with T3 squamous cell laryngeal carcinomas are nowadays offered either organ-preserving surgical or non-surgical treatment, with the optimum approach remaining undefined. No direct comparison of organ-preserving therapeutical options, stratified by anatomical subsites is available in the literature. The aim of this study is to present institutional treatment outcomes for laser-assisted microsurgery (TLM) of laryngeal T3 squamous cell carcinomas and review the relevant literature. Sixty-four consecutive, previously untreated patients were evaluated. Twenty-four supraglottic and 19 glottic patients were treated with TLM and neck dissection, tumor exposure and postoperative upstaging of the tumors through pathology evaluation of the specimens being the only exclusion criteria. Five-year disease-specific survival and organ preservation rates for supraglottic carcinomas were both 91.7 %. The respective values for glottic carcinomas were 63.2 and 73.3 %. TLM-treated T3 supraglottic tumors seem to attribute better outcomes than T3 glottic tumors in terms of recurrence-free survival, organ preservation and local control (p = 0.01, <0.0001 and 0.01, respectively). The results of this study suggest that TLM-treated T3 supraglottic tumors have a good prognosis, substantially better than that of glottic tumors. A literature review, on the other hand, attributes to chemo-radiation-treated T3 supraglottic tumors a considerably poorer prognosis. Further studies of homogenous populations in terms of anatomical subsites are needed in order to reach a consensus regarding treatment of T3 laryngeal tumors.
authors.affiliation: ENT Department, "Thriasion" Hospital of Athens, Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Pantazis
authors.forename: Georgia
authors.initials: G
authors.lastname: Liapi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kostarelos
authors.forename: Georgios
authors.initials: G
authors.lastname: Kyriazis
authors.forename: Theodoros-Leonidas
authors.initials: TL
authors.lastname: Pantazis
authors.forename: Maria
authors.initials: M
authors.lastname: Riga
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D005260:Female; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006115:Greece; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D053685:Laser Therapy / Q000009:adverse effects / Q000379:methods; D008297:Male; D008866:Microsurgery / Q000009:adverse effects / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging; D059351:Organ Sparing Treatments / Q000009:adverse effects / Q000379:methods; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
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