title: Negative life events have detrimental effects on in-vitro fertlization outcome.
abstract: The aim of this study was to investigate the effect of negative life events on in-vitro-fertilization (IVF) outcome. Depression and negative life events were measured using Beck Depression Inventory (BDI) and List of Recent Events in 83 women attending the IVF clinic of a tertiary research and education hospital with the diagnosis of unexplained infertility between January 2013 and August 2013. Demographic features, stimulation parameters, depression scores, and negative life events of pregnant and non-pregnant participants were compared and the relation between negative life events, depression scores, and IVF outcome was investigated. Women who did not achieve a pregnancy experienced more negative life events than women who became pregnant (77.2% vs. 23.1%) (p > 0.001). The number of patients with moderate-to-severe depression (BDI scores > 16) was higher in the non-pregnant group than pregnant group (49.1% vs. 26.9%), however the difference was not statistically significant (p = 0.057). Clinical pregnancy showed a significant moderate negative correlation with the number of negative life events (r = -0.513, p = 0.001), but the correlation between clinical pregnancy and BDI scores was not statistically significant (r = -0.209, p = 0.059). Stressful life events have a negative influence on the quality of life, which eventually affects in IVF outcome, possibly through maladaptive lifestyle behavior.
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Nafiye
authors.initials: N
authors.lastname: Yilmaz
authors.affiliation: b Department of Obstetrics and Gynecology , Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital , Ankara , Turkey.
authors.forename: İnci
authors.initials: İ
authors.lastname: Kahyaoglu
authors.affiliation: c Department of Obstetrics and Gynecology , Konyma Research and Education Hospital , Konya , Turkey.
authors.forename: Hasan Ali
authors.initials: HA
authors.lastname: İnal
authors.affiliation: d Hitit University Faculty of Medicine, Department of Obstetrics and Gynecology , Corum , Turkey.
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Görkem
authors.affiliation: a Department of Obstetrics and Gynecology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Devran
authors.affiliation: b Department of Obstetrics and Gynecology , Etlik Zubeyde Hanım Women's Health Teaching and Research Hospital , Ankara , Turkey.
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000150:complications; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000523:psychology*; D006801:Humans; D007246:Infertility / Q000628:therapy; D011247:Pregnancy; D011788:Quality of Life / Q000523:psychology*; D016896:Treatment Outcome; D014421:Turkey; D055815:Young Adult
keywords: IVF outcome; Negative life events; depression; in-vitro fertilization