title: Basal level of Th17 immune response is not enhanced in aplastic amemia.
abstract: Acquired aplastic anemia (AA) is an immune mediated bone marrow failure syndrome which is associated with impaired T-cell immune responses. In this work we investigated the role of Th17 immune response in AA. Our results showed that the absolute numbers of circulating IL-17-producing CD4(+) T cells and CD4(+)CD161(+)CCR6(+) cells, the blood plasma level of IL-17, and the expression level of Th17 lineage-specifying transcription factor RORC in circulating CD4(+) T cells, were not increased in AA. These results suggest that Th17 immune response may not play an important role in the pathogenesis of AA.
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Jizhou
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Yao
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Neng
authors.initials: N
authors.lastname: Nie
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Meili
authors.initials: M
authors.lastname: Ge
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shi
authors.affiliation: Severe Aplastic Anemia Studying Program, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, P.R. China. Electronic address: zheng_yizhou@hotmail.com.
authors.forename: Yizhou
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000276:immunology*; D008297:Male; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000097:blood / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human
keywords: Aplastic anemia; CD4(+)CD161(+)CCR6(+); IL-17; RORC; Th17