title: Controlled drug release from cross-linked κ-carrageenan/hyaluronic acid membranes.
abstract: In this work, hydrogel membrane composed of; kappa carrageenan (κC) and hyaluronic acid (HA) crosslinked with epichlorohydrine is produced. The optimum condition has been established based on their water absorption properties. Tensile strength (TS) and elongation (E%) for the formed films are evaluated. The obtained films were characterized by FTIR, scanning electron microscopy (SEM) and thermal analysis. All membranes were loaded with l-carnosine as a drug model. The swelling properties and kinetics of the release of the model drug from the crosslinked hydrogel membrane were monitored in buffer medium at 37°C. The equilibrium swelling of films showed fair dependency on the high presence of HA in the hydrogel. Moreover, the cumulative release profile increased significantly and ranged from 28% to 93%, as HA increases. SEM explored that, the porosity increased by increasing HA content; consequently, drug release into the pores and channels of the membranes is facilitated. In addition, water uptake % increased as well. A slight change in TS occurred by increasing the HA% to κC, while the highest value of strain for κC membrane was 498.38% by using 3% HA. The thermal stability of the κC/HA was higher than that of HA.
authors.affiliation: Polymer Materials Research Department, Advanced Technology and New Material Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934 Alexandria, Egypt. Electronic address: mohamed_elaassar@yahoo.com.
authors.forename: M R
authors.initials: MR
authors.lastname: El-Aassar
authors.affiliation: Polymer Materials Research Department, Advanced Technology and New Material Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934 Alexandria, Egypt.
authors.forename: G F
authors.initials: GF
authors.lastname: El Fawal
authors.affiliation: Polymer Materials Research Department, Advanced Technology and New Material Institute, City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, 21934 Alexandria, Egypt.
authors.forename: Elbadawy A
authors.initials: EA
authors.lastname: Kamoun
authors.affiliation: Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia; Textile Research Division, National Research Center, Dokki, PO Box 12622, Giza 12522, Egypt. Electronic address: mmfoudah@ksu.edu.sa.
authors.forename: Moustafa M G
authors.initials: MM
authors.lastname: Fouda
mesh_terms: D002336:Carnosine / Q000737:chemistry; D002351:Carrageenan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004811:Epichlorohydrin / Q000032:analysis; D006820:Hyaluronic Acid / Q000737:chemistry*; D007700:Kinetics; D055595:Mechanical Phenomena; D008567:Membranes, Artificial; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008567:Membranes, Artificial; D004811:Epichlorohydrin; D002336:Carnosine; D002351:Carrageenan; D006820:Hyaluronic Acid
keywords: Hyaluronic acid; Hydrogels; drug release; l-Carnosine; κ-Carrageenan