title: The potential use of mesenchymal stem cells in stroke therapy--From bench to bedside.
abstract: Stroke is the second main cause of morbidity and mortality worldwide. The rationale for the use of mesenchymal stem cells (MSCs) in stroke is based on the capacity of MSCs to secrete a large variety of bioactive molecules such as growth factors, cytokines and chemokines leading to reduction of inflammation, increased neurogenesis from the germinative niches of central nervous system, increased angiogenesis, effects on astrocytes, oligodendrocytes and axons. This review presents the data derived from experimental studies and the evidence available from clinical trials about the use of MSCs in stroke therapy.
authors.affiliation: U.M.F. "Carol Davila", Fundeni Clinical Institute, Department of Neurology, 258 Sos. Fundeni, Sector 2, Bucharest, Romania. Electronic address: adrianadulamea@gmail.com.
authors.forename: Adriana Octaviana
authors.initials: AO
authors.lastname: Dulamea
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D020521:Stroke / Q000503:physiopathology / Q000628:therapy*
keywords: Angiogenesis; Clinical trial; Inflammation; Mesenchymal stem cells; Neurogenesis; Stroke