title: Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after laparoscopic gynecological surgery.
abstract: BACKGROUND
  Opioids are widely used in boluses and patient-controlled analgesia (PCA) for postoperative pain control. In this study, we compared the effects of oxycodone and fentanyl on postoperative pain in patients with intravenous patient-controlled analgesia (IV-PCA) after laparoscopic gynecological surgery.
  
  
  METHODS
  Seventy-four patients undergoing elective total laparoscopic hysterectomy or laparoscopic myomectomy were randomly assigned to the administration of either fentanyl or oxycodone using IV-PCA (potency ratio 1 : 60). The cumulative dose administered in the patient-controlled mode during the initial 48 hours after the operation was measured. Patients were also assessed for postoperative pain severity, adverse effects, and patient satisfaction.
  
  
  RESULTS
  No significant differences were observed in patient satisfaction with the analgesia during the postoperative period. Patients in the oxycodone group experienced significantly more dizziness compared to the fentanyl group. Patients in the oxycodone group showed significantly lower consumption of opioid in the patient-controlled mode (10.1 ± 8.5 ml vs. 16.6 ± 12.0 ml, P = 0.013).
  
  
  CONCLUSIONS
  Our data suggest that oxycodone and fentanyl demonstrated similar effects, and therefore oxycodone may be a good alternative to fentanyl in postoperative pain management. Further studies in various clinical settings will be needed to determine the adequate potency ratio.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Joong-Ho
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Chiu
authors.initials: C
authors.lastname: Lee
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Youngmin
authors.initials: Y
authors.lastname: Shin
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: An
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Jong-Seouk
authors.initials: JS
authors.lastname: Ban
authors.affiliation: Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
authors.forename: Ji-Hyang
authors.initials: JH
authors.lastname: Lee
keywords: Fentanyl; Oxycodone; Patient-controlled analgesia; Postoperative pain
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