title: JAK3 talks down to renal 25-hydroxyvitamin D 1α-hydroxylase.
abstract: 25-Hydroxyvitamin D 1α-hydroxylase CYP27B1 is expressed in several extrarenal tissues. In the immune system, and likely elsewhere, its expression is not regulated by calcium and phosphate homeostatic inputs. Umbach et al. provide evidence that inflammatory cytokine signaling may also control CYP27B1 expression in renal epithelia. Mice lacking JAK3, a kinase essential for immune homeostasis, displayed mild renal inflammation, elevated renal CYP27B1 expression, and altered phosphate metabolism, linking immune signaling to vitamin D metabolism in the kidney.
authors.affiliation: 1] Department of Physiology, McGill University, Montreal, Quebec, Canada [2] Department of Medicine, McGill University, Montreal, Quebec, Canada.
authors.forename: John H
authors.initials: JH
authors.lastname: White
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics*; D000818:Animals; D002117:Calcitriol / Q000097:blood*; D005260:Female; D053616:Janus Kinase 3 / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D010710:Phosphates; D012333:RNA, Messenger; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D053616:Janus Kinase 3; D002117:Calcitriol