title: Gene Expression in Placentas From Nondiabetic Women Giving Birth to Large for Gestational Age Infants.
abstract: Gestational diabetes, obesity, and excessive weight gain are known independent risk factors for the birth of a large for gestational age (LGA) infant. However, only 1 of the 10 infants born LGA is born by mothers with diabetes or obesity. Thus, the aim of the present study was to compare placental gene expression between healthy, nondiabetic mothers (n = 22) giving birth to LGA infants and body mass index-matched mothers (n = 24) giving birth to appropriate for gestational age infants. In the whole gene expression analysis, only 29 genes were found to be differently expressed in LGA placentas. Top upregulated genes included insulin-like growth factor binding protein 1, aminolevulinate δ synthase 2, and prolactin, whereas top downregulated genes comprised leptin, gametocyte-specific factor 1, and collagen type XVII α 1. Two enriched gene networks were identified, namely, (1) lipid metabolism, small molecule biochemistry, and organismal development and (2) cellular development, cellular growth, proliferation, and tumor morphology.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden fredrik.ahlsson@kbh.uu.se.
authors.forename: F
authors.initials: F
authors.lastname: Ahlsson
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Åkerud
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Schijven
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden Department of Behavioral Physiology, University of Groningen, Groningen, the Netherlands Centre for Gender Medicine, Karolinska Institutet, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Olivier
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Sundström-Poromaa
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D020411:Oligonucleotide Array Sequence Analysis; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger
keywords: and prolactin; large for gestational age; leptin; microarray; placental gene expression