title: Incidence and clinical characteristics of pulmonary hypertension in patients with idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Pulmonary hypertension (PH) frequently complicates the course of idiopathic pulmonary fibrosis (IPF) patients and is associated with significantly worse outcomes. The aim of the present study was to investigate the incidence of PH in IPF patients and evaluate the correlation between clinical parameters and systolic pulmonary artery pressure (sPAP).
  
  
  METHODS
  Hospitalized patients with IPF, who were evaluated for sPAP by Doppler echocardiography from January 2004 to December 2011, were enrolled in our study. Patients were defined as PH by an estimated sPAP > 50 mmHg and graded as PH likely, PH possible and PH unlikely, based on the 2009 European Society of Cardiology/European Respiratory Society PH Guidelines. The correlations between clinical parameters and sPAP were analyzed by multiple linear regression.
  
  
  RESULTS
  Totally, 119 IPF patients were enrolled in our study and 28 (23.5%), 20 (16.8%) and 71 (59.7%) patients were PH likely, PH possible and PH unlikely, respectively. Borg dyspnea score was positively correlated with sPAP, r = 0.467, P < 0.001. Oxygen saturation was negatively correlated with sPAP, r = -0.416, P < 0.001. Diffusing capacity of the lung for carbon monoxide percentage predicted was negatively correlated with sPAP, r = -0.424, P = 0.003. N-terminal fragment of pro-brain natriuretic peptide and pulmonary artery width was positively correlated with sPAP, r = 0.452, P = 0.011 and r = 0.513, P < 0.001, respectively.
  
  
  CONCLUSIONS
  The incidence of PH in IPF patients was 23.5% in a single center of China. PH may worsen the dyspnea, right heart dysfunction and decrease the life quality of the patients with IPF.
authors.forename: Wei
authors.initials: W
authors.lastname: Yan
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Peng
authors.forename: Cheng-Jun
authors.initials: CJ
authors.lastname: Ban
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zhai
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University; Beijing Key Laboratory of Respiratory and Pulmonary Circulation, Beijing Institute of Respiratory Medicine, Beijing 100020, China.
authors.forename: Hua-Ping
authors.initials: HP
authors.lastname: Dai
mesh_terms: D000368:Aged; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D054990:Idiopathic Pulmonary Fibrosis / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011651:Pulmonary Artery / Q000503:physiopathology; D012907:Smoking
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
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