title: Control of energy balance by the brain renin-angiotensin system.
abstract: The renin-angiotensin system (RAS) exists as a circulating hormone system but it is also used by various tissues of the body, including the brain, as a paracrine signaling mechanism. The local brain version of the RAS is mechanistically involved in fluid balance and blood pressure control, and there is growing appreciation for a role of the brain RAS in the control of energy balance. Here, we review major evidence for the control of energy balance by the brain RAS; outline the current understanding of the RAS components, targets, and mechanisms involved; and highlight some major questions that currently face the field.
authors.affiliation: Department of Pharmacology, Center for Hypertension Research, Obesity Research & Education Initiative, François M. Abboud Cardiovascular Research Center, and Fraternal Order of Eagles' Diabetes Research Center, University of Iowa, 51 Newton Rd., 2-307 BSB, Iowa City, IA, 52242, USA.
authors.forename: Kristin E
authors.initials: KE
authors.lastname: Claflin
authors.forename: Justin L
authors.initials: JL
authors.lastname: Grobe
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000502:physiology*; D004734:Energy Metabolism; D006801:Humans; D009765:Obesity / Q000378:metabolism; D012084:Renin-Angiotensin System; D014882:Water-Electrolyte Balance / Q000502:physiology
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