title: Apical iodide efflux in thyroid.
abstract: Thyroid follicular epithelial cells produce thyroxine (T4) and its physiologically active derivative, 3,3',5-triiodothyronine (T3), hormones that regulate critical developmental and metabolic functions. In order for the thyroid to form hormone precursor, iodide, the defining element in thyroid hormone, must cross both blood-facing and luminal sides of the follicular epithelium. The pathway for uptake from blood is well understood, but the mechanism(s) that enable iodide to cross the luminally facing apical membrane remain obscure. This chapter considers the physiological properties of several molecularly characterized anion transport proteins, all of which potentially contribute to the overall mechanism of apical iodide efflux.
authors.affiliation: Department of Anatomy and Physiology, Kansas State University College of Veterinary Medicine, Manhattan, Kansas, USA. Electronic address: pfong@vet.k-state.edu.
authors.forename: Peying
authors.initials: P
authors.lastname: Fong
mesh_terms: D001693:Biological Transport, Active / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D007454:Iodides / Q000378:metabolism*; D017136:Ion Transport / Q000502:physiology*; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism; D013963:Thyroid Hormones / Q000502:physiology; D014284:Triiodothyronine / Q000502:physiology
chemical_list: D007454:Iodides; D013963:Thyroid Hormones; D014284:Triiodothyronine
keywords: Anion; Epithelium; Hormone; Iodide; Membrane transport; Thyroid