title: Plasma jet's shielding gas impact on bacterial inactivation.
abstract: One of the most desired aims in plasma medicine is to inactivate prokaryotic cells and leave eukaryotic cells unharmed or even stimulate proliferation to promote wound healing. The method of choice is to precisely control the plasma component composition. Here the authors investigate the inactivation of bacteria (Escherichia coli) by a plasma jet treatment. The reactive species composition created by the plasma in liquids is tuned by the use of a shielding gas device to achieve a reactive nitrogen species dominated condition or a reactive oxygen species dominated condition. A strong correlation between composition of the reactive components and the inactivation of the bacteria is observed. The authors compare the results to earlier investigations on eukaryotic cells and show that it is possible to find a plasma composition where bacterial inactivation is strongest and adverse effects on eukaryotic cells are minimized.
authors.affiliation: Center for Innovation Competence plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany and Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Helena
authors.initials: H
authors.lastname: Jablonowski
authors.affiliation: Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Mareike A Ch
authors.initials: MA
authors.lastname: Hänsch
authors.affiliation: Center for Innovation Competence plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany and Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Dünnbier
authors.affiliation: Center for Innovation Competence plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany and Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Kristian
authors.initials: K
authors.lastname: Wende
authors.affiliation: Center for Innovation Competence plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany and Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Malte U
authors.initials: MU
authors.lastname: Hammer
authors.affiliation: Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Klaus-Dieter
authors.initials: KD
authors.lastname: Weltmann
authors.affiliation: Center for Innovation Competence plasmatis, Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany and Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Reuter
authors.affiliation: Leibniz Institute for Plasma Science and Technology, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489 Greifswald, Germany.
authors.forename: Thomas von
authors.initials: Tv
authors.lastname: Woedtke
mesh_terms: D004202:Disinfectants / Q000009:adverse effects / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000528:radiation effects*; D050296:Microbial Viability / Q000187:drug effects* / Q000528:radiation effects*; D058626:Plasma Gases / Q000009:adverse effects / Q000494:pharmacology*; D026361:Reactive Nitrogen Species / Q000378:metabolism / Q000633:toxicity; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000633:toxicity
chemical_list: D004202:Disinfectants; D058626:Plasma Gases; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species