title: Designing synthetic vaccines for HIV.
abstract: Despite three decades of intensive research efforts, the development of an effective prophylactic vaccine against HIV remains an unrealized goal in the global campaign to contain the HIV/AIDS pandemic. Recent characterization of novel epitopes for inducing broadly neutralizing antibodies has fueled research in the design and synthesis of new, well-defined antigenic constructs for the development of HIV envelope-directed vaccines. The present review will cover previous and recent efforts toward the design of synthetic vaccines based on the HIV viral envelope glycoproteins, with special emphasis on examples from our own laboratories. The biological evaluation of some of the most representative vaccine candidates, in terms of their antigenicity and immunogenicity, will also be discussed to illustrate the current state-of-the-art toward the development of fully synthetic HIV vaccines.
authors.affiliation: Laboratory for Bioorganic Chemistry, Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute for Cancer Research, 1275 York Avenue, NY 10065, USA.
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernández-Tejada
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D057134:Antibodies, Neutralizing / Q000097:blood; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D014614:Vaccines, Synthetic / Q000276:immunology / Q000302:isolation & purification
chemical_list: D016915:AIDS Vaccines; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D014614:Vaccines, Synthetic
keywords: AIDS; HIV vaccine design; broadly neutralizing antibody; carbohydrates; glycopeptides; glycosylation; gp120; synthetic antigen
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