title: Diffusion weighted imaging and apparent diffusion coefficient in 3 tesla magnetic resonance imaging of breast lesions.
abstract: OBJECTIVE
  To evaluate the utility of diffusion-weighted-imaging (DWI) and apparent-diffusion-coefficient (ADC) in a 3T magnetic-resonance-imaging (MRI) study of breast cancer. In particular, the study aims to classify ADC-values according to histology either for benign or malignant lesions.
  
  
  METHODS
  110 Breast MRI with MRI-DWI sequences and quantitative evaluation of the ADC were retrospectively reviewed. Results obtained with MRI-DWI and with biopsy were analyzed and ADC values were compared to histological results.
  
  
  RESULTS
  MRI showed a 95.5% sensitivity and a 83.7% specificity. The mean ADC values of benign and malignant lesions were 2.06 ± 0.19 and 1.03 ± 0.07 mm(2)/s, respectively (p < .05).
  
  
  CONCLUSIONS
  DWI and ADC-values could help distinguishing malignant and benign breast masses.
authors.affiliation: 1IRCCS-CROB, Rionero in Vulture , Italy.
authors.forename: Rocchina
authors.initials: R
authors.lastname: Caivano
authors.forename: Antonio
authors.initials: A
authors.lastname: Villonio
authors.forename: Felice
authors.initials: F
authors.lastname: D' Antuono
authors.forename: Matilde
authors.initials: M
authors.lastname: Gioioso
authors.forename: Paola
authors.initials: P
authors.lastname: Rabasco
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Iannelli
authors.forename: Alexis
authors.initials: A
authors.lastname: Zandolino
authors.forename: Antonella
authors.initials: A
authors.lastname: Lotumolo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Dinardo
authors.forename: Luca
authors.initials: L
authors.lastname: Macarini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Guglielmi
authors.forename: Aldo
authors.initials: A
authors.lastname: Cammarota
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D011859:Radiography
keywords: 3T magnetic resonance imaging; Apparent diffusion coefficient; Breast cancer; Diffusion weighted imaging