title: In vivo measurement reproducibility of femoral neck microarchitectural parameters derived from 3T MR images.
abstract: OBJECTIVE
  To evaluate the within-day and between-day measurement reproducibility of in vivo 3D MRI assessment of trabecular bone microarchitecture of the proximal femur.
  
  
  METHODS
  This Health Insurance Portability and Accountability Act (HIPPA)-compliant, Institutional Review Board (IRB)-approved study was conducted on 11 healthy subjects (mean age = 57.4 ± 14.1 years) with written informed consent. All subjects underwent a 3T MRI hip scan in vivo (0.234 × 0.234 × 1.5 mm) at three timepoints: baseline, second scan same day (intrascan), and third scan 1 week later (interscan). We applied digital topological analysis and volumetric topological analysis to compute the following microarchitectural parameters within the femoral neck: total bone volume, bone volume fraction, markers of trabecular number (skeleton density), connectivity (junctions), plate-like structure (surfaces), plate width, and trabecular thickness. Reproducibility was assessed using root-mean-square coefficient of variation (RMS-CV) and intraclass correlation coefficient (ICC).
  
  
  RESULTS
  The within-day RMS-CVs ranged from 2.3% to 7.8%, and the between-day RMS-CVs ranged from 4.0% to 7.3% across all parameters. The within-day ICCs ranged from 0.931 to 0.989, and the between-day ICCs ranged from 0.934 to 0.971 across all parameters.
  
  
  CONCLUSIONS
  These results demonstrate high reproducibility for trabecular bone microarchitecture measures derived from 3T MR images of the proximal femur. The measurement reproducibility is within a range suitable for clinical cross-sectional and longitudinal studies in osteoporosis.
authors.affiliation: Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, New York, New York, USA.|Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, New York, USA.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hotca
authors.affiliation: Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Chamith S
authors.initials: CS
authors.lastname: Rajapakse
authors.affiliation: Department of Radiology and Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Osteoporosis Center, Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Honig
authors.affiliation: Department of Orthopedic Surgery, Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York, USA.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Egol
authors.affiliation: Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, New York, USA.
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
authors.affiliation: Department of Radiology and Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA.
authors.forename: Punam K
authors.initials: PK
authors.lastname: Saha
authors.affiliation: Department of Radiology, NYU Langone Medical Center, Center for Musculoskeletal Care, New York, New York, USA.|Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, New York, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Chang
mesh_terms: D005260:Female; D005272:Femur Neck / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results
keywords: 3T MRI; digital topological analysis; hip; microarchitecture; osteoporosis; volumetric topological analysis
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