title: The most fulminant course of the Marburg variant of multiple sclerosis-autopsy findings.
abstract: Multiple sclerosis (MS) is usually a chronic and disabling inflammatory disease. Marburg's type of MS is characterized by rapid progression and severe disease course that leads to death within one year after the onset of clinical signs. We describe a fulminant clinical presentation of this malignant subtype of MS and discuss the neuropathological hallmarks as well as differential diagnoses of other fulminant demyelinating diseases. To the best of our knowledge, this is the most fulminant course of this MS variant reported in the literature.
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany/Centro de Neurociências Aplicadas (CeNAp), Universidade Federal de Santa Catarina, Brazil jeanmedic@hotmail.com.
authors.forename: J C
authors.initials: JC
authors.lastname: Nunes
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Radbruch
authors.affiliation: Centro de Neurociências Aplicadas (CeNAp), Universidade Federal de Santa Catarina, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Walz
authors.affiliation: Centro de Neurociências Aplicadas (CeNAp), Universidade Federal de Santa Catarina, Brazil.
authors.forename: K
authors.initials: K
authors.lastname: Lin
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Stenzel
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Prokop
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Koch
authors.affiliation: Charité-Universitätsmedizin Berlin, Germany.
authors.forename: F L
authors.initials: FL
authors.lastname: Heppner
mesh_terms: D000328:Adult; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020528:Multiple Sclerosis, Chronic Progressive / Q000473:pathology* / Q000503:physiopathology
keywords: Demyelinating diseases; Marburg variant; multiple sclerosis; neuropathology