title: Association between rs6812193 polymorphism and sporadic Parkinson's disease susceptibility.
abstract: Recently, the association of a single nucleotide polymorphism rs6812193 C/T with sporadic Parkinson's disease (PD) susceptibility has been widely evaluated, but the results remained inconsistent. This association should be clarified because of the importance of it on human health and quality of life. We performed a comprehensive meta-analysis to evaluate the association between the rs6812193 polymorphism and sporadic PD. PubMed was used to retrieve articles published up to June 2014 for all studies evaluating the rs6812193 polymorphism and PD in humans. Ethnicity-specific subgroup analysis was also performed based on ethnicity susceptibility. A total of 17 independent study samples (15 Caucasians and 2 Asians) including 17,956 cases and 52,751 controls were used in the presented study. The MAFT (minor allele T frequency) in PD patients of European descent is obviously higher than Asian cases (p < 0.01). The results suggested the rs6812193 polymorphism (allele T vs. C) is significantly associated with PD susceptibility among overall samples (OR 0.882, 95 % CI 0.856-0.908) and Caucasian population (OR 0.881, 95 % CI 0.856-0.907), but not in Asian samples (OR 0.918, 95 % CI 0.721-1.168). No evidence of publication bias was observed. Throughout our analysis, the rs6812193 polymorphism is significantly associated with sporadic PD susceptibility in Caucasian samples, and ethnicity might be the key point of inconsistency in rs6812193 studies. Further studies are warranted to re-examine the observed associations, especially in different ethnicities.
authors.affiliation: Department of Orthopaedic Surgery, Zibo Central Hospital, 54 West Gongqingtuan Road, Zibo, 255036, Shandong Province, China, hq329311270@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Huo
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Peiqing
authors.initials: P
authors.lastname: Zhao
authors.forename: Lianqing
authors.initials: L
authors.lastname: Wang
mesh_terms: D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D051907:Lysosomal Membrane Proteins / Q000235:genetics*; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D039781:PubMed / Q000706:statistics & numerical data; D051116:Receptors, Scavenger / Q000235:genetics*
chemical_list: D051907:Lysosomal Membrane Proteins; D051116:Receptors, Scavenger; C074299:SCARB2 protein, human
references.citation: Neurosci Lett. 2013 Apr 29;541:190-2
references.pmid: 23473716
references.citation: Mov Disord. 2012 Mar;27(3):400-5
references.pmid: 22223122
references.citation: Neurosci Lett. 2012 May 10;516(1):21-3
references.pmid: 22465138
references.citation: Hum Mol Genet. 2010 Feb 15;19(4):563-72
references.pmid: 19933215
references.citation: Neurosci Lett. 2010 Jul 19;479(1):31-3
references.pmid: 20478361
references.citation: Mov Disord. 2013 Apr;28(4):538-40
references.pmid: 23408458
references.citation: Neurosci Lett. 2012 May 23;517(1):56-9
references.pmid: 22531747
references.citation: PLoS Genet. 2011 Jun;7(6):e1002142
references.pmid: 21738488
references.citation: PLoS Genet. 2011 Jun;7(6):e1002141
references.pmid: 21738487