title: Anaphylaxis to drugs.
abstract: Drug-induced anaphylaxis is a common cause of anaphylaxis and a leading cause of fatal anaphylaxis. Antibiotics, radiocontrast, and nonsteroidal anti-inflammatory drugs are commonly implicated drugs. Vocal cord dysfunction can mimic anaphylaxis and is often overlooked. β-Lactams are a common cause of anaphylaxis; however, skin testing and drug challenge can usually determine tolerability of other classes of β-lactams. Nonionic contrast agents cause anaphylaxis less frequently than ionic contrast, and immunoglobulin E-mediated mechanisms may have a role in some of these reactions. Skin testing with radiocontrast may have a role in evaluating patients with anaphylaxis to nonionic contrast.
authors.affiliation: Atlanta ENT, 5555 Peachtree Dunwoody Rd, Suite 125, Atlanta, GA-30342, USA.
authors.forename: Merin
authors.initials: M
authors.lastname: Kuruvilla
authors.affiliation: Division of Allergy & Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8859, USA. Electronic address: dave.khan@utsouthwestern.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Khan
mesh_terms: D000707:Anaphylaxis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D015897:Comorbidity; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000276:immunology; D006801:Humans; D004364:Pharmaceutical Preparations / Q000145:classification; D012307:Risk Factors
chemical_list: D004364:Pharmaceutical Preparations
keywords: Anaphylaxis; Cephalosporin; Drug; NSAID; Penicillin; Proton pump inhibitor; Radiocontrast; Vocal cord dysfunction