title: [Association of D2 dopamine receptor gene -141C Ins/Del polymorphisms with heroin dependence in Chinese Han population: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the association between D2 dopamine receptor gene -141C Ins/Del polymorphism and heroin dependence in Chinese Han population.
  
  
  METHODS
  Chinese and foreign databases were searched for relevant articles published from the establishment of database to March 2014. Case-control studies on D2 dopamine receptor gene -141C Ins/Del polymorphism with heroin dependence in Chinese Han population were gathered with Meta-analysis by Stata 12.0 software after data abstraction.
  
  
  RESULTS
  Seven case-control studies on association between D2 dopamine receptor gene -141C Ins/ Del polymorphism and heroin dependence were included, which covered 3 211 heroin dependence patients and 1 979 controls. Meta-analysis results showed that the pooled odds ratio (OR), the 95% confidence interval (CI) and P value after combining genotypes were as follows: Ins/Ins vs Del/Del: OR=0.51, 95% CI: 0.27-0.96, P=0.017; Ins/Ins vs Ins/Del+Del/Del: OR=0.82, 95% CI: 0.72-0.94, P=0.448; Ins/Ins+ Ins/Del vs Del/Del: OR=0.53, 95% CI: 0.28-0.98, P=0.019; Ins/Del vs Del/Del: OR=0.59, 95% CI: 0.32-1.07, P=0.045; Ins vs Del: OR=0.79, 95% CI: 0.71-0.89, P=0.101).
  
  
  CONCLUSIONS
  D2 dopamine receptor gene -141C Ins/Del polymorphism is associated with heroin dependence in Chinese Han population, and Chinese Han population with Ins allele gene deletion are at lower risk of heroin dependence.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China.
authors.forename: Peiwu
authors.initials: P
authors.lastname: Hu
authors.forename: Xingli
authors.initials: X
authors.lastname: Li
authors.forename: Shasha
authors.initials: S
authors.lastname: Peng
authors.forename: Xi
authors.initials: X
authors.lastname: Luo
authors.forename: Zhisheng
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005838:Genotype; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D054643:INDEL Mutation; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2