title: Evaluating the effect of polytetrafluoroethylene and extractum cepae-heparin-allantoin gel in peripheral nerve injuries in a rat model.
abstract: BACKGROUND
  Peripheral nerves can be injured by congenital, mechanical, thermal or chemical causes. Peripheral nerve injuries are increasing in frequency, particularly in countries that are becoming more industrialized. Nerve and extremity injuries result in work loss and high treatment costs, and can lead to separation of patients from their social environment. Failure of nerve repair causes muscle functional losses, sensory losses and painful neuropathies.
  
  
  OBJECTIVE
  To compare the effects of condensed polytetrafluoroethylene (cPTFE) and cPTFE-extractum cepae-heparin-allantoin (cPTFE-EHA) gel compound on nerve and functional recovery, and the prevention of adhesion and scar tissue formation after total peripheral nerve injury repaired by primary suture in a rat model.
  
  
  RESULTS
  cPTFE alone and cPTFE-EHA gel was found to provide better functional recovery and nerve regeneration compared with primary repair only. In the macroscopic evaluation, the cPTFE-EHA gel was found to have no negative effect on wound healing and, despite increasing extra-neural scar tissue and adhesions, it had no negative effect on nerve function; in addition, it facilitated functional recovery.
  
  
  CONCLUSIONS
  Compared with the cPTFE application alone, the application of perineural cPTFE-EHA gel during peripheral nerve surgery appeared to provide better functional recovery without causing any significant changes in epineural and extraneural scar tissue formation.
authors.affiliation: Department of Plastic Reconstructive and Aesthetic Surgery, Mustafa Kemal University, Antakya, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kahraman
authors.affiliation: Department of Plastic Reconstructive and Aesthetic Surgery, Mustafa Kemal University, Antakya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kahveci
keywords: Extractum cepae-heparin-allantoin gel; Perineural scar; Peripheral nerve injury; Regeneration
references.citation: J Reconstr Microsurg. 2004 Feb;20(2):153-7
references.pmid: 15011124
references.citation: Neurosurgery. 2005 Apr;56(2 Suppl):425-33; discussion 425-33
references.pmid: 15794840
references.citation: Fertil Steril. 1991 Feb;55(2):389-94
references.pmid: 1991536
references.citation: Plast Reconstr Surg. 1992 Feb;89(2):251-8
references.pmid: 1732892
references.citation: J Neurosci Methods. 2001 Jul 15;108(1):1-9
references.pmid: 11459612
references.citation: Plast Reconstr Surg. 1996 Dec;98(7):1264-71, discussion 1272-4
references.pmid: 8942915
references.citation: Obstet Gynecol Surv. 2004 May;59(5):360-7
references.pmid: 15097797
references.citation: In Vivo. 2006 Mar-Apr;20(2):277-83
references.pmid: 16634531
references.citation: Tissue Eng. 2001 Dec;7(6):679-89
references.pmid: 11749726
references.citation: Plast Reconstr Surg. 1994 Jun;93(7):1323-33
references.pmid: 8208799
references.citation: Acta Neurochir (Wien). 1998;140(12):1303-7
references.pmid: 9932133
references.citation: Przegl Dermatol. 1988 Sep-Oct;75(5):352-7
references.pmid: 3253799
references.citation: J South Orthop Assoc. 2001 Fall;10(3):173-89
references.pmid: 12132829
references.citation: Surg Neurol. 2007 Dec;68(6):615-22; discussion 622
references.pmid: 18053855
references.citation: J Neurosurg Sci. 2003 Dec;47(4):195-9; discussion 199-200
references.pmid: 14978473
references.citation: Microsurgery. 2003;23(6):575-81
references.pmid: 14705074
references.citation: J Appl Biomater. 1990 Spring;1(1):13-9
references.pmid: 10148985
references.citation: J Bone Joint Surg Br. 2004 Mar;86(2):301-7
references.pmid: 15046451
references.citation: Neurosurgery. 1996 May;38(5):976-83; discussion 983-4
references.pmid: 8727824
references.citation: J Neurosurg. 2004 Oct;101(4):648-52
references.pmid: 15481720
references.citation: J Neurosci Methods. 1998 Nov 1;85(1):119-27
references.pmid: 9874148
references.citation: J Biomed Mater Res A. 2007 Aug;82(2):426-35
references.pmid: 17295248
references.citation: J Hand Surg Am. 2000 May;25(3):391-414
references.pmid: 10811744
references.citation: J Craniofac Surg. 2003 Nov;14(6):859-65
references.pmid: 14600627
references.citation: J Am Acad Orthop Surg. 2000 Jul-Aug;8(4):243-52
references.pmid: 10951113
references.citation: Neurosurgery. 2003 Dec;53(6):1389-95; discussion 1395-6
references.pmid: 14633305
references.citation: J Hand Surg Am. 2000 Mar;25(2):252-9
references.pmid: 10722816
references.citation: J Biomed Mater Res A. 2006 Feb;76(2):234-42
references.pmid: 16116600
references.citation: Klin Khir. 2001 Feb;(2):24-7
references.pmid: 11482019
references.citation: Ann Plast Surg. 2002 Apr;48(4):392-400
references.pmid: 12068222
references.citation: Int J Clin Pharmacol Res. 1994;14(5-6):193-202
references.pmid: 7672876
references.citation: Br J Plast Surg. 2003 Jun;56(4):342-7
references.pmid: 12873461
references.citation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Mar;89(3):292-8
references.pmid: 10710452
references.citation: J Int Med Res. 2003 Nov-Dec;31(6):509-16
references.pmid: 14708416
references.citation: Microsurgery. 1989;10(3):226-35
references.pmid: 2796719
references.citation: Br J Oral Maxillofac Surg. 1998 Oct;36(5):327-32
references.pmid: 9831051
references.citation: Pesqui Odontol Bras. 2003 Apr-Jun;17(2):126-31
references.pmid: 14569353
references.citation: Br J Plast Surg. 2005 Jun;58(4):533-40
references.pmid: 15897039