title: Genome-based nutrition: an intervention strategy for the prevention and treatment of obesity and nonalcoholic steatohepatitis.
abstract: Obesity and nonalcoholic steatohepatitis are increasing in westernized countries, regardless of their geographic location. In Latin America, most countries, including Mexico, have a heterogeneous admixture genome with Amerindian, European and African ancestries. However, certain high allelic frequencies of several nutrient-related polymorphisms may have been achieved by past gene-nutrient interactions. Such interactions may have promoted the positive selection of variants adapted to regional food sources. At present, the unbalanced diet composition of the Mexicans has led the country to a 70% prevalence rate of overweightness and obesity due to substantial changes in food habits, among other factors. International guidelines and intervention strategies may not be adequate for all populations worldwide because they do not consider disparities in genetic and environmental factors, and thus there is a need for differential prevention and management strategies. Here, we provide the rationale for an intervention strategy for the prevention and management of obesity-related diseases such as non-alcoholic steatohepatitis based on a regionalized genome-based diet. The components required to design such a diet should focus on the specific ancestry of each population around the world and the convenience of consuming traditional ethnic food.
authors.affiliation: Sonia Roman, Claudia Ojeda-Granados, Omar Ramos-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
authors.forename: Sonia
authors.initials: S
authors.lastname: Roman
authors.affiliation: Sonia Roman, Claudia Ojeda-Granados, Omar Ramos-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ojeda-Granados
authors.affiliation: Sonia Roman, Claudia Ojeda-Granados, Omar Ramos-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
authors.forename: Omar
authors.initials: O
authors.lastname: Ramos-Lopez
authors.affiliation: Sonia Roman, Claudia Ojeda-Granados, Omar Ramos-Lopez, Arturo Panduro, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara, "Fray Antonio Alcalde", Guadalajara, Jalisco, Mexico and Health Sciences Center, University of Guadalajara, Guadalajara, Jalisco 44280, Mexico.
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
mesh_terms: D004032:Diet / Q000009:adverse effects / Q000208:ethnology; D005247:Feeding Behavior / Q000208:ethnology; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D015438:Health Behavior / Q000208:ethnology; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy* / Q000208:ethnology / Q000235:genetics / Q000517:prevention & control*; D009752:Nutritional Status / Q000208:ethnology / Q000235:genetics; D009765:Obesity / Q000178:diet therapy* / Q000208:ethnology / Q000235:genetics / Q000517:prevention & control*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors
keywords: Evolution; Food history; Gene-nutrient interactions; Latin America; Mexico; Nonalcoholic steatohepatitis; Obesity; Western diet
references.citation: J Nutr. 1994 Jul;124(7):1052-9
references.pmid: 8027855
references.citation: J Biol Chem. 2001 Jun 29;276(26):23742-7
references.pmid: 11309399
references.citation: Curr Opin Lipidol. 2008 Jun;19(3):229-34
references.pmid: 18460912
references.citation: Prog Cardiovasc Dis. 2014 Nov-Dec;57(3):276-85
references.pmid: 25218566
references.citation: Am J Clin Nutr. 2006 Feb;83(2):436S-442S
references.pmid: 16470009
references.citation: Transl Res. 2007 Mar;149(3):114-25
references.pmid: 17320797
references.citation: Endocrinol Metab Clin North Am. 2010 Jun;39(2):419-46, table of contents
references.pmid: 20511061
references.citation: Evol Appl. 2013 Jun;6(4):596-607
references.pmid: 23789027
references.citation: BMC Med Genet. 2008;9:104
references.pmid: 19040733
references.citation: Am J Clin Nutr. 2010 Nov;92(5):1257-64
references.pmid: 20861173
references.citation: Rev Invest Clin. 1996 Nov;48 Suppl:15-22
references.pmid: 9122543
references.citation: Ann Hum Biol. 2006 May-Jun;33(3):279-308
references.pmid: 17092867
references.citation: FEBS Lett. 1992 Aug 24;308(3):267-70
references.pmid: 1505665
references.citation: Acta Cir Bras. 2013 Nov;28(11):788-93
references.pmid: 24316747
references.citation: Nat Genet. 2007 Oct;39(10):1256-60
references.pmid: 17828263
references.citation: Indian J Med Res. 2010 Oct;132:363-78
references.pmid: 20966513
references.citation: Trends Genet. 2006 Aug;22(8):437-46
references.pmid: 16808986
references.citation: Am J Phys Anthropol. 2009 Jul;139(3):284-94
references.pmid: 19140185
references.citation: Chemosens Percept. 2010 Dec 1;3(3-4):137-148
references.pmid: 21157576
references.citation: J Diabetes. 2013 Dec;5(4):406-15
references.pmid: 23560695
references.citation: Med Clin (Barc). 2011 Jan 29;136(2):45-9
references.pmid: 21051057
references.citation: World J Gastroenterol. 2009 Apr 21;15(15):1809-15
references.pmid: 19370776
references.citation: Am J Hum Genet. 2004 Apr;74(4):637-46
references.pmid: 14997422
references.citation: J Nutrigenet Nutrigenomics. 2008;1(1-2):24-9
references.pmid: 19918112
references.citation: PLoS Comput Biol. 2009 Aug;5(8):e1000491
references.pmid: 19714206
references.citation: Obesity (Silver Spring). 2012 May;20(5):1066-73
references.pmid: 22240721
references.citation: J Nutr. 2004 Jun;134(6):1447-53
references.pmid: 15173410
references.citation: Nutr J. 2009;8:46
references.pmid: 19799794
references.citation: PLoS Genet. 2009 Jun;5(6):e1000500
references.pmid: 19503611
references.citation: J Am Diet Assoc. 1997 Jul;97(7 Suppl):S63-9
references.pmid: 9216571
references.citation: J Hum Genet. 2012 Sep;57(9):568-74
references.pmid: 22832385
references.citation: Cad Saude Publica. 2003;19 Suppl 1:S77-86
references.pmid: 12886438
references.citation: Diabetologia. 2015 Feb;58(2):290-4
references.pmid: 25394825
references.citation: Trends Endocrinol Metab. 2009 Mar;20(2):72-7
references.pmid: 19185504
references.citation: Cell Biochem Funct. 2008 Apr;26(3):291-6
references.pmid: 17563923
references.citation: Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1702-9
references.pmid: 19966311
references.citation: Hum Biol. 2006 Feb;78(1):65-75
references.pmid: 16900882
references.citation: Biochem J. 2007 Mar 15;402(3):591-600
references.pmid: 17313375
references.citation: Dis Markers. 2010;28(5):323-31
references.pmid: 20592457
references.citation: Endocrinology. 2007 Jun;148(6):2753-63
references.pmid: 17347305
references.citation: Clin Genet. 2005 Apr;67(4):275-80
references.pmid: 15733260
references.citation: J Lipid Res. 2003 Feb;44(2):296-302
references.pmid: 12576511
references.citation: Curr Biol. 2010 Feb 23;20(4):R166-73
references.pmid: 20178763
references.citation: Hum Hered. 2013;76(3-4):154-61
references.pmid: 24861860
references.citation: Can J Gastroenterol. 2008 Oct;22(10):811-6
references.pmid: 18925303
references.citation: Hepat Mon. 2014 Feb 17;14(2):e10939
references.pmid: 24693306
references.citation: J Lipid Res. 2012 Mar;53(3):561-6
references.pmid: 22210925
references.citation: Nature. 2010 Apr 8;464(7290):908-12
references.pmid: 20376150
references.citation: Public Health Nutr. 2004 Feb;7(1A):123-46
references.pmid: 14972057
references.citation: Evolution (N Y). 2011 Dec;4(4):567-573
references.pmid: 25221636
references.citation: Curr Opin Clin Nutr Metab Care. 2012 Mar;15(2):107-11
references.pmid: 22248592
references.citation: Saudi Med J. 2012 May;33(5):489-94
references.pmid: 22588808
references.citation: Ann Genet. 2000 Apr-Jun;43(2):89-92
references.pmid: 10998450
references.citation: Cell Host Microbe. 2013 Nov 13;14(5):491-7
references.pmid: 24237695
references.citation: Cerebrovasc Dis. 2010;29(5):454-9
references.pmid: 20203488
references.citation: Alcohol Clin Exp Res. 2008 Apr;32(4):559-66
references.pmid: 18241317
references.citation: Nat Rev Neurosci. 2011 Nov;12(11):638-51
references.pmid: 22011680
references.citation: Ann N Y Acad Sci. 2008 Oct;1141:163-75
references.pmid: 18991957
references.citation: Am J Clin Nutr. 2002 Jul;76(1):180-6
references.pmid: 12081832
references.citation: IUBMB Life. 2007 Apr-May;59(4-5):308-15
references.pmid: 17505970
references.citation: Diabetes Care. 2011 Jun;34(6):1249-57
references.pmid: 21617109
references.citation: Hepatology. 2005 May;41(5):995-1003
references.pmid: 15834927
references.citation: Nat Rev Endocrinol. 2013 Jan;9(1):13-27
references.pmid: 23165161
references.citation: Nature. 2012 Aug 16;488(7411):370-4
references.pmid: 22801491
references.citation: Can J Gastroenterol. 2008 Jan;22(1):61-8
references.pmid: 18209783
references.citation: Biochimie. 2007 Feb;89(2):265-9
references.pmid: 17126471
references.citation: Dig Liver Dis. 2010 Apr;42(4):272-82
references.pmid: 20171943
references.citation: J Nutr. 2006 Sep;136(9):2325-30
references.pmid: 16920849
references.citation: J Diabetes. 2012 Sep;4(3):266-80
references.pmid: 22564417
references.citation: Nutrients. 2014 Jan;6(1):124-62
references.pmid: 24379011
references.citation: Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112
references.pmid: 16447287
references.citation: BMJ Open. 2011 Jul 29;1(1):e000125
references.pmid: 22021768
references.citation: Eur J Clin Nutr. 2007 Dec;61 Suppl 1:S132-7
references.pmid: 17992184
references.citation: Curr Genomics. 2011 May;12(3):180-9
references.pmid: 22043166
references.citation: Arq Bras Endocrinol Metabol. 2009 Mar;53(2):129-38
references.pmid: 19466204
references.citation: Public Health Nutr. 2002 Feb;5(1A):113-22
references.pmid: 12027273
references.citation: Nat Rev Genet. 2003 Feb;4(2):99-111
references.pmid: 12560807
references.citation: Am J Med Sci. 2005 Dec;330(6):326-35
references.pmid: 16355018
references.citation: J Nutr Sci Vitaminol (Tokyo). 2013;59(6):560-3
references.pmid: 24477254
references.citation: Ann Hum Biol. 2001 Mar-Apr;28(2):111-42
references.pmid: 11293722
references.citation: Gastroenterol Hepatol (N Y). 2010 Dec;6(12):780-92
references.pmid: 21301632
references.citation: Obesity (Silver Spring). 2011 Aug;19(8):1707-14
references.pmid: 21193851
references.citation: J Biomed Res. 2013 Jan;27(1):1-13
references.pmid: 23554788
references.citation: Am J Clin Nutr. 2007 Aug;86(2):285-300
references.pmid: 17684197
references.citation: Oxid Med Cell Longev. 2009 Nov-Dec;2(5):270-8
references.pmid: 20716914
references.citation: Science. 2003 Feb 21;299(5610):1221-5
references.pmid: 12595690
references.citation: Mol Genet Metab. 1999 Dec;68(4):461-7
references.pmid: 10607475
references.citation: J Physiol Pharmacol. 2013 Dec;64(6):711-7
references.pmid: 24388885
references.citation: Curr Opin Clin Nutr Metab Care. 2006 Sep;9(5):637-42
references.pmid: 16912563
references.citation: J Nutrigenet Nutrigenomics. 2012;5(3):117-31
references.pmid: 22965187
references.citation: J Food Sci. 2012 Mar;77(3):S143-7
references.pmid: 22384968
references.citation: J Clin Gastroenterol. 2014 Jul;48(6):467-73
references.pmid: 24921212
references.citation: J Acad Nutr Diet. 2014 Feb;114(2):299-312
references.pmid: 24439821
references.citation: J Clin Gastroenterol. 2012 Aug;46(7):555-61
references.pmid: 22772737
references.citation: Hum Mol Genet. 2010 Jul 15;19(14):2877-85
references.pmid: 20418488
references.citation: Hum Mol Genet. 2004 Oct 1;13(19):2197-205
references.pmid: 15282206
references.citation: Crit Rev Food Sci Nutr. 2005;45(4):287-306
references.pmid: 16047496
references.citation: Annu Rev Nutr. 1996;16:417-42
references.pmid: 8839933
references.citation: J Nutr Biochem. 2011 Aug;22(8):699-711
references.pmid: 21292470
references.citation: J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S51-60
references.pmid: 16540769
references.citation: Am J Clin Nutr. 2006 Mar;83(3):701-7
references.pmid: 16522920
references.citation: Circ J. 2014;78(12):2807-18
references.pmid: 25391910
references.citation: Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8924-30
references.pmid: 20445095
references.citation: Hepatology. 2012 Jun;55(6):2005-23
references.pmid: 22488764