title: Proteomic study of retinal proteins associated with transcorneal electric stimulation in rats.
abstract: Background. To investigate how transcorneal electric stimulation (TES) affects the retina, by identifying those proteins up- and downregulated by transcorneal electric stimulation (TES) in the retina of rats. Methods. Adult Wistar rats received TES on the left eyes at different electrical currents while the right eyes received no treatment and served as controls. After TES, the eye was enucleated and the retina was isolated. The retinas were analyzed by proteomics. Results. Proteomics showed that twenty-five proteins were upregulated by TES. The identified proteins included cellular signaling proteins, proteins associated with neuronal transmission, metabolic proteins, immunological factors, and structural proteins. Conclusions. TES induced changes in expression of various functional proteins in the retina.
authors.affiliation: Department of Ophtahlomology, Hiroshima Memorial Hospital, 1-4-3 Honkawacho, Minami-ku, Hiroshima 730-0802, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanamoto
authors.affiliation: Personalized Cancer Medicine Unit, Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Nazariy
authors.initials: N
authors.lastname: Souchelnytskyi
authors.affiliation: Department of Ophthalmology, Osaka Medical College, 2-7 Daigaku-cho, Takatsuki-shi, Osaka 569-8686, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Kurimoto
authors.affiliation: Department of Ophthalmology, Kyushu University, 3-1-1 Maedashi, Higashi-ku, Fukuoka 812-8592, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ikeda
authors.affiliation: Department of Pharmaceutical Sciences, International University of Health and Welfare, 2600-1 Kitakanemaru, Tahara-shi, Tochigi 324-8501, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakaue
authors.affiliation: Department of Ophthalmology, St. Marianna Medical College, 2-16-1 Sugao, Miyamae-ku, Kawasaki-shi, Kanagawa 216-8511, Japan.
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Munemasa
authors.affiliation: Department of Ophthalmology and Visual Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshiam 734-8551, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiuchi
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