title: Preparation and characterization of host-guest system between inosine and β-cyclodextrin through inclusion mode.
abstract: Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N₉-glycosidic bond. Inosine is commonly found in tRNAs. Inosine (INS) has been used widely as an antiviral drug. The inclusion complex of INS with β-CDx in solution phase is studied by ground and excited state with UV-visible and fluorescence spectroscopy, respectively. A binding constant and stoichiometric ratio between INS and β-CDx are calculated by BH equation. The lifetime and relative amplitude of INS is increases with increasing the concentrations of β-CDx, confirms the formation of inclusion complex in liquid state. The solid complexes are prepared by kneading method (KM) and co-precipitation method (CP). The solid complex is characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), powder X-ray diffraction (XRD) and differential scanning colorimetry (DSC). CP method gives the solid product with good yield than that of physical mixture and KM method. The structure of complex is proposed based on the study of Patch - Dock server.
authors.affiliation: Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India; Department of Chemistry, SKP. Engineering College, Tiruvannamalai 606 611, Tamil Nadu, India.
authors.forename: Samikannu
authors.initials: S
authors.lastname: Prabu
authors.affiliation: Department of Chemistry, SCSVMV University, Kanchipuram 631 561, Tamil Nadu, India.
authors.forename: Krishnamurty
authors.initials: K
authors.lastname: Sivakumar
authors.affiliation: Department of Chemistry, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
authors.forename: Meenakshisundaram
authors.initials: M
authors.lastname: Swaminathan
authors.affiliation: Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India; Department of Chemistry, SKP. Institute of Technology, Tiruvannamalai 606 611, Tamil Nadu, India. Electronic address: rajmohanau@gmail.com.
authors.forename: Rajaram
authors.initials: R
authors.lastname: Rajamohan
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D007288:Inosine / Q000008:administration & dosage* / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D062105:Molecular Docking Simulation; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D047392:beta-Cyclodextrins; D007288:Inosine; C031215:betadex
keywords: DSC; Inclusion complex; Inosine β-cyclodextrin; Patch – Dock server; XRD