title: Hyperhomocysteinemia, a biochemical tool for differentiating ischemic and nonischemic central retinal vein occlusion during the early acute phase.
abstract: OBJECTIVE
  The purpose of the study was to differentiate ischemic central retinal vein occlusion (CRVO) from nonischemic CRVO during the early acute phase using plasma homocysteine as a biochemical marker.
  
  
  METHODS
  Fasting plasma homocysteine, serum vitamin B12, and folate levels were measured in 108 consecutive unilateral elderly adult (age >50 years) ischemic CRVO patients in the absence of local and systemic disease and compared with a total of 144 age and sex matched nonischemic CRVO patients and 120 age and sex matched healthy control subjects.
  
  
  RESULTS
  Homocysteine level was significantly increased in the patients with ischemic CRVO in comparison with nonischemic CRVO patients (p = 0.009) and also in comparison with control subjects (p < 0.001). Analysis also showed that hyperhomocysteinemia was associated with increased incidence of ischemic CRVO (odds ratio, 18) than that for nonischemic CRVO (odds ratio, 4.5). Serum vitamin B12 and folate levels were significantly lower (p < 0.001) in CRVO patients compared to the control but were not significantly different between nonischemic and ischemic CRVO patients (p > 0.1).
  
  
  CONCLUSIONS
  Hyperhomocysteinemia can be regarded as useful in differentiating nonischemic and ischemic CRVO during the early acute phase in absence of local and systemic disease in the elderly adult (age >50 years) population.
authors.affiliation: Department of Biochemistry, ESI-PGIMSR & ESIC Medical College Joka, Kolkata, India.
authors.forename: Kapil Deb
authors.initials: KD
authors.lastname: Lahiri
authors.affiliation: Department of Ophthalmology, N R S Medical College, Kolkata, India.
authors.forename: Somnath
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Ophthalmology, North Bengal Medical College, Siliguri, India.
authors.forename: Sambuddha
authors.initials: S
authors.lastname: Ghosh
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Kolkata, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Mukherjee
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Kolkata, India.
authors.forename: Jayanta
authors.initials: J
authors.lastname: Dutta
authors.affiliation: Department of Ophthalmology, Regional Institute of Ophthalmology, Kolkata, India.
authors.forename: Himadri
authors.initials: H
authors.lastname: Datta
authors.affiliation: Department of Biochemistry, RG Kar Medical College & Hospital, Kolkata, India.
authors.forename: Harendra Nath
authors.initials: HN
authors.lastname: Das
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000150:complications / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D015415:Biomarkers
keywords: Central retinal vein occlusion; Homocysteine; Hyperhomocysteinemia; Ischemic central retinal vein occlusion; Nonischemic central retinal vein occlusion
references.citation: J Nutr. 2006 Jun;136(6 Suppl):1726S-1730S
references.pmid: 16702347
references.citation: Graefes Arch Clin Exp Ophthalmol. 1990;228(3):201-17
references.pmid: 2361592
references.citation: Thromb Res. 2008;121(5):699-703
references.pmid: 17719079
references.citation: Indian J Clin Biochem. 2013 Jan;28(1):61-4
references.pmid: 24381423
references.citation: Arch Ophthalmol. 1996 Oct;114(10):1243-7
references.pmid: 8859084
references.citation: Am J Ophthalmol. 2006 Aug;142(2):322-4
references.pmid: 16876518
references.citation: Indian J Clin Biochem. 2014 Jan;29(1):74-8
references.pmid: 24478553
references.citation: Clin Chem. 1993 Sep;39(9):1764-79
references.pmid: 8375046
references.citation: Curr Drug Metab. 2005 Feb;6(1):27-36
references.pmid: 15720205
references.citation: Am J Ophthalmol. 2003 Dec;136(6):1136-50
references.pmid: 14644226
references.citation: Clin Chem Lab Med. 2005;43(10):1076-83
references.pmid: 16197301
references.citation: Clin Invest Med. 2000 Aug;23(4):220-6
references.pmid: 10981532
references.citation: Retina. 2006 Jan;26(1):65-70
references.pmid: 16395141
references.citation: J Nutr. 2006 Jun;136(6 Suppl):1741S-1749S
references.pmid: 16702349
references.citation: J Nutr. 2006 Jun;136(6 Suppl):1750S-1754S
references.pmid: 16702350
references.citation: Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):508-13
references.pmid: 16373615
references.citation: Thromb Haemost. 2005 Jun;93(6):1021-6
references.pmid: 15968383
references.citation: Curr Eye Res. 2008 Feb;33(2):111-31
references.pmid: 18293182
references.citation: Am J Ophthalmol. 2005 Jan;139(1):181-2
references.pmid: 15652845
references.citation: Ophthalmologica. 2009;223(5):298-305
references.pmid: 19372724
references.citation: Ophthalmology. 2007 Mar;114(3):520-4
references.pmid: 17141315
references.citation: Ophthalmology. 2010 Feb;117(2):313-9.e1
references.pmid: 20022117
references.citation: Ophthalmology. 1983 May;90(5):458-74
references.pmid: 6877778