title: Us9-Independent Axonal Sorting and Transport of the Pseudorabies Virus Glycoprotein gM.
abstract: Axonal sorting and transport of fully assembled pseudorabies virus (PRV) virions is dependent on the viral protein Us9. Here we identify a Us9-independent mechanism for axonal localization of viral glycoprotein M (gM). We detected gM-mCherry assemblies transporting in the anterograde direction in axons. Furthermore, unlabeled gM, but not glycoprotein B, was detected by Western blotting in isolated axons during Us9-null PRV infection. These results suggest that gM differs from other viral proteins regarding axonal transport properties.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kratchmarov
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
authors.forename: L W
authors.initials: LW
authors.lastname: Enquist
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA Department of Microbiology and Immunology, Montana State University, Bozeman, Montana, USA mptaylor@montana.edu.
authors.forename: M P
authors.initials: MP
authors.lastname: Taylor
mesh_terms: D001369:Axons / Q000821:virology*; D011558:Herpesvirus 1, Suid / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D021381:Protein Transport; D014759:Viral Envelope Proteins / Q000378:metabolism*; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins; D010750:Phosphoproteins; C491630:US9 protein, Suid herpesvirus 1; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C042966:pseudorabies virus glycoproteins
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