title: Glucose metabolism provide distinct prosurvival benefits to non-small cell lung carcinomas.
abstract: Heterogeneity within the same tumor type has been described to be complex and occur at multiple levels. Less is known about the heterogeneity at the level of metabolism, within a tumor set, yet metabolic pathways are highly relevant to survival signaling in tumors. In this study, we profiled the glucose metabolism of several non-small cell lung carcinoma (NSCLC) cell lines and could show that, NSCLC display distinct glycolytic metabolism. Genetic and pharmacological perturbation of glycolysis was selectively toxic to NSCLCs with high rates of glycolysis. Furthermore, high expression of hexokinase-2, localized at the mitochondria, was a feature of the NSCLCs dependent on glucose catabolism. Our study provides evidence for quantitative metabolic diversity in NSCLCs and indicates that glucose metabolism provide differential prosurvival benefits to NSCLCs.
authors.affiliation: Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Wu
authors.affiliation: Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
authors.forename: Lorena
authors.initials: L
authors.lastname: Galan-Acosta
authors.affiliation: Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: Erik.Norberg@ki.se.
authors.forename: Erik
authors.initials: E
authors.lastname: Norberg
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D010085:Oxidative Phosphorylation
chemical_list: D005947:Glucose
keywords: Cell death; Glycolysis; Heterogeneity; Metabolism; NSCLC