title: Effect of persistent and transient hypothyroidism on histoarchitecture and antioxidant defence system in rat brain.
abstract: The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism. Enhanced level of LPx was observed in transient hypothyroid rats with respect to control and persistent hypothyroid rats. Significantly increased activity of SOD and expression of SOD1 were observed in cerebral cortex of both persistent and transient hypothyroid rats as compared to control. However, unaltered translated level of SOD2 was observed among the groups. Activity of CAT was increased in transient hypothyroid rats, whereas translate level of CAT was increased in both the regions of persistent as well as transient hypothyroidism. The histoarchitecture of cerebral cortex clearly showed a decline in neuronal migration with neurons packed together in both persistent and transient hypothyroid rats as compared to control. These results suggest that deprivation of thyroid hormone modulates redox status and causes oxidative stress in rat brain cerebral cortex during postnatal development and maturation.
authors.affiliation: Department of Biotechnology, Utkal University, Bhubaneswar, 751004, Odisha, India, jenasrikanta@yahoo.co.in.
authors.forename: Srikanta
authors.initials: S
authors.lastname: Jena
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D013956:Antithyroid Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D013956:Antithyroid Agents; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
references.citation: Int J Dev Neurosci. 2008 Apr;26(2):147-209
references.pmid: 18031969
references.citation: Free Radic Biol Med. 1999 Jan;26(1-2):73-80
references.pmid: 9890642
references.citation: Acta Physiol Hung. 2005;92(1):39-46
references.pmid: 16003944
references.citation: Cell Signal. 2007 Apr;19(4):672-82
references.pmid: 17204396
references.citation: Crit Rev Toxicol. 2005 Oct-Nov;35(8-9):771-81
references.pmid: 16417044
references.citation: Nature. 2002 Sep 19;419(6904):316-21
references.pmid: 12239572
references.citation: Brain Res Dev Brain Res. 2003 Oct 10;145(1):19-29
references.pmid: 14519490
references.citation: Hippocampus. 2009 Jan;19(1):66-78
references.pmid: 18680156
references.citation: Anal Biochem. 1970 Mar;34:30-8
references.pmid: 5440916
references.citation: Metab Brain Dis. 2008 Sep;23(3):275-87
references.pmid: 18683039
references.citation: Neurol Sci. 2012 Aug;33(4):869-73
references.pmid: 22076484
references.citation: Int J Dev Neurosci. 2010 May;28(3):251-62
references.pmid: 20123122
references.citation: Neurol Sci. 2014 Aug;35(8):1269-74
references.pmid: 24595920
references.citation: N Engl J Med. 1994 Dec 29;331(26):1739-44
references.pmid: 7984194
references.citation: Endocr Rev. 1997 Aug;18(4):462-75
references.pmid: 9267760
references.citation: Gen Comp Endocrinol. 2012 Aug 1;178(1):8-18
references.pmid: 22522343
references.citation: Trends Endocrinol Metab. 2000 May-Jun;11(4):123-8
references.pmid: 10754532
references.citation: Cell Biochem Funct. 2003 Dec;21(4):325-30
references.pmid: 14624470
references.citation: Neurobiol Aging. 1997 Sep-Oct;18(5):457-61
references.pmid: 9390770
references.citation: Neurochem Res. 2013 Jan;38(1):42-9
references.pmid: 22987056
references.citation: Neurosci Res. 2001 Jul;40(3):273-9
references.pmid: 11448519
references.citation: Biochem J. 1973 Jul;134(3):707-16
references.pmid: 4749271
references.citation: Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2696-701
references.pmid: 8610103
references.citation: Toxicol Sci. 2011 Dec;124(2):432-45
references.pmid: 21964421
references.citation: J Neurosci. 2004 Aug 18;24(33):7324-34
references.pmid: 15317858
references.citation: Anal Biochem. 1979 Jun;95(2):351-8
references.pmid: 36810
references.citation: J Neurochem. 1997 Jun;68(6):2469-76
references.pmid: 9166741
references.citation: FASEB J. 1996 May;10(7):709-20
references.pmid: 8635688
references.citation: Neurochem Res. 2004 Sep;29(9):1755-66
references.pmid: 15453272
references.citation: Endocr Rev. 1993 Feb;14(1):94-106
references.pmid: 8491157