title: Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pharmacology/Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah.
authors.forename: Chris
authors.initials: C
authors.lastname: Stockmann
authors.affiliation: Department of Pharmacology/Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Reilly
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Fassl
authors.affiliation: Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Mo.
authors.forename: Roger
authors.initials: R
authors.lastname: Gaedigk
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Flory
authors.initials: F
authors.lastname: Nkoy
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Bryan
authors.initials: B
authors.lastname: Stone
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Jessica K
authors.initials: JK
authors.lastname: Roberts
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Derek A
authors.initials: DA
authors.lastname: Uchida
authors.affiliation: Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Mo.
authors.forename: J Steven
authors.initials: JS
authors.lastname: Leeder
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Catherine M T
authors.initials: CM
authors.lastname: Sherwin
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Spigarelli
authors.affiliation: Department of Pharmacology/Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah.
authors.forename: Garold S
authors.initials: GS
authors.lastname: Yost
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; Department of Pharmacology/Toxicology, University of Utah College of Pharmacy, Salt Lake City, Utah. Electronic address: Robert.Ward@hsc.utah.edu.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Ward
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000276:immunology; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D001507:Beclomethasone / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D051544:Cytochrome P-450 CYP3A / Q000235:genetics* / Q000276:immunology; D019468:Disease Management; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D001189:Aryl Hydrocarbon Hydroxylases; C510164:CYP3A5 protein, human; C103123:CYP3A7 protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D001507:Beclomethasone
references.citation: Nat Genet. 2001 Apr;27(4):383-91
references.pmid: 11279519
references.citation: Genetics. 1987 Oct;117(2):331-41
references.pmid: 3666445
references.citation: J Allergy Clin Immunol. 2005 Feb;115(2):233-42
references.pmid: 15696076
references.citation: Xenobiotica. 2006 Dec;36(12):1191-200
references.pmid: 17162466
references.citation: J Allergy Clin Immunol. 2007 Nov;120(5 Suppl):S94-138
references.pmid: 17983880
references.citation: Pharmacogenomics J. 2011 Aug;11(4):274-86
references.pmid: 20386561
references.citation: N Engl J Med. 2011 Sep 29;365(13):1173-83
references.pmid: 21991891
references.citation: N Engl J Med. 2011 Sep 29;365(13):1245-6
references.pmid: 21991898
references.citation: J Pharmacol Exp Ther. 2013 May;345(2):308-16
references.pmid: 23512537
references.citation: J Pediatr. 2013 Jun;162(6):1222-7, 1227.e1-2
references.pmid: 23290512