title: Development and evaluation of gel-forming ocular films based on xyloglucan.
abstract: This study aims at application of xyloglucan, polysaccharide polymer as novel film forming agent for ocular delivery of ciprofloxacin. Ciprofloxacin ocular films were prepared by the solvent casting method using xuloglucan (2%). The prepared formulations were evaluated for thickness, percentage drug content, surface pH, swelling, mechanical strength and in vitro drug release. The films were found to be of uniform thickness (0.20 ± 0.07 μm). The % drug content in the films was found to be 95.45 ± 0.25%. The cumulative % drug releases from the formulation was 98.85 at the end of 24h. The formulations followed the anomalous transport release mechanism. Ocular irritancy study reveals safety of formulation to ocular mucosa. Thus, this study suggests that xyloglucan can act as a potential film forming polymer for ocular delivery of a ciprofloxacin.
authors.affiliation: R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule 425405, Maharashtra, India. Electronic address: hsmahajan@rediffmail.com.
authors.forename: Hitendra S
authors.initials: HS
authors.lastname: Mahajan
authors.affiliation: R.C. Patel Institute of Pharmaceutical Education and Research, Near Karvand Naka, Shirpur, Dhule 425405, Maharashtra, India.
authors.forename: Sachin R
authors.initials: SR
authors.lastname: Deshmukh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002939:Ciprofloxacin / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D005123:Eye / Q000187:drug effects*; D005782:Gels / Q000737:chemistry; D005936:Glucans / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D014990:Xylans / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D005936:Glucans; D009883:Ophthalmic Solutions; D011108:Polymers; D014990:Xylans; C029353:xyloglucan; D002939:Ciprofloxacin
keywords: Ciprofloxacin; Ocular delivery; Polymeric films; Xyloglucan