title: Guiding principles in the design of molecular bioconjugates for vaccine applications.
abstract: Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure-function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.
authors.affiliation: †Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, United States.|‡Department of Oncology, Wayne State University, Detroit, Michigan 48201, United States.|§Tumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, United States.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Liu
authors.affiliation: ▼Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.
authors.forename: Darrell J
authors.initials: DJ
authors.lastname: Irvine
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology; D015195:Drug Design; D006801:Humans; D008208:Lymphatic System / Q000276:immunology; D014612:Vaccines / Q000737:chemistry / Q000276:immunology*
chemical_list: D014612:Vaccines
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