title: Oral cyclosporine A treatment is feasible after myeloablative conditioning in allogeneic hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  The target level and route of administration of cyclosporine A (CsA) differ between transplantation centres. It is unclear whether oral CsA is sufficient to maintain target level of CsA.
  
  
  METHODS
  We retrospectively analysed data from 48 adult patients, who underwent myeloablative hematopoietic stem cell transplantation. Twenty-one patients (44%) tolerated CsA orally throughout the transplantation period without increased incidence of acute graft versus host disease(aGVHD). Low concentration of CsA in week 2 was associated with increased incidence of aGVHD.
  
  
  CONCLUSIONS
  Oral administration of CsA is safe, less time-consuming and economically advantageous. Close monitoring of CsA concentration is important.
authors.affiliation: Hematological department, National University Hospital Rigshospitalet, Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Nygaard
authors.forename: D
authors.initials: D
authors.lastname: Hovgaard
authors.forename: I M
authors.initials: IM
authors.lastname: Schjødt
authors.forename: N S
authors.initials: NS
authors.lastname: Andersen
authors.forename: L
authors.initials: L
authors.lastname: Vindeløv
authors.forename: H
authors.initials: H
authors.lastname: Sengeløv
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019172:Transplantation Conditioning / Q000379:methods*; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine
keywords: cost-effectiveness; cyclosporine; intravenous infusions; oral administration; therapeutic drug monitoring