title: Evaluation of function and structure of arterial wall in girls and young women with Turner syndrome.
abstract: OBJECTIVE
  Patients with Turner syndrome (TS) are frequently affected by congenital as well as acquired cardiovascular diseases. The aim of the study was to evaluate the blood pressure, the endothelial function (FMD) and the intima media thickness (IMT) at the level of the common carotid arteries in a group of girls and young women with TS in comparison to healthy controls.
  
  
  METHODS
  We evaluated 40 unselected TS patients, with a mean age of 18.6 ± 0.9 years and 103 age matched healthy subjects.
  
  
  METHODS
  blood pressure, FMD and IMT.
  
  
  RESULTS
  No differences were found in systolic and diastolic blood pressure between TS patients and controls. FMD was higher in TS than in controls (14.2 ± 1.4 vs 11.4 ± 0.3%, p = 0.005) whereas IMT was not statistically different in the two study groups (0.54 ± 0.04 vs 0.57 ± 0.01 mm). However, in TS patients an inverse correlation was found between FMD and both age (-0.03 ± 0.01, p = 0.003) and years of estrogen therapy (-0.72 ± 0.31, p < 0.03), whereas a positive correlation was found between IMT and age (R 2 = 0.35, p < 0.0001) and estrogen therapy duration (R 2 = 0.65, p < 0.0001), suggesting a clear tendency toward a premature decrease in FMD and premature increase in IMT compared to controls.
  
  
  CONCLUSIONS
  Young TS patients show an arterial wall which is functionally and structurally comparable or better than controls. They show, however, a premature derangement of the arterial function and structure, which seems to be partly influenced by age and duration of oestrogen treatment.
authors.affiliation: Department of Paediatrics, Regional Hospital of Bolzano, via L. Boehler 5, 39100, Bolzano, Italy, giorgio.radetti@asbz.it.
authors.forename: G
authors.initials: G
authors.lastname: Radetti
authors.forename: L
authors.initials: L
authors.lastname: Mazzanti
authors.forename: C
authors.initials: C
authors.lastname: Di Somma
authors.forename: M
authors.initials: M
authors.lastname: Salerno
authors.forename: E
authors.initials: E
authors.lastname: Gottardi
authors.forename: D
authors.initials: D
authors.lastname: Capalbo
authors.forename: F
authors.initials: F
authors.lastname: Tamburrino
authors.forename: A
authors.initials: A
authors.lastname: Colao
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D002648:Child; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D014424:Turner Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D004997:Ethinyl Estradiol
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