title: [Is the biological clock central to the aging process? Studies in a non-human primate].
abstract: The ability of organisms to adapt to their environment during aging is altered. Age-related disorders in Human include disturbances of biological rhythms, especially sleep-wake rhythms alterations, and perturbations of body temperature and hormone secretion. The alteration of biological rhythms with age leads to major health consequences, particularly due to the alteration of sleep-wake rhythms that causes a strong alteration of the general condition. The study of these changes is therefore a major health issue and requires the use of appropriate animal models such as the grey mouse lemur (Microcebus murinus), a small Madagascar primate with very pronounced biological rhythms.
authors.forename: Fabien
authors.initials: F
authors.lastname: Pifferi
authors.forename: Fabienne
authors.initials: F
authors.lastname: Aujard
authors.forename: Martine
authors.initials: M
authors.lastname: Perret
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D016565:Cheirogaleidae / Q000502:physiology*; D021081:Chronobiology Disorders / Q000503:physiopathology; D057906:Circadian Clocks / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D006801:Humans; D008136:Longevity / Q000502:physiology* / Q000528:radiation effects; D008297:Male; D017440:Photoperiod; D012621:Seasons; D013045:Species Specificity