title: BAFF receptors and ligands create independent homeostatic niches for B cell subsets.
abstract: The BAFF family of receptors and ligands controls B cell homeostasis and selection. Recent studies reveal distinct sources and roles for systemic versus locally produced BAFF. Moreover, the notion that differential BAFF receptor expression patterns establish independent homeostatic and selective niches has been strengthened. Finally, unique roles for BAFF family members in the regulation of antigen experienced and innate B cell subsets have been revealed. Herein, we overview current knowledge in these areas, emphasizing recent findings that inform these ideas.
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States. Electronic address: cancro@mail.med.upenn.edu.
authors.forename: Martin S
authors.initials: MS
authors.lastname: Naradikian
authors.affiliation: Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Alison R
authors.initials: AR
authors.lastname: Perate
authors.affiliation: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Cancro
mesh_terms: D000818:Animals; D053265:B-Cell Activation Factor Receptor / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*; D060833:Cellular Microenvironment; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000378:metabolism
chemical_list: D053265:B-Cell Activation Factor Receptor; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13