title: Synthesis and evaluation of naphthalene-based thiosemicarbazone derivatives as new anticancer agents against LNCaP prostate cancer cells.
abstract: Fourteen new naphthalene-based thiosemicarbazone derivatives were designed as anticancer agents against LNCaP human prostate cancer cells and synthesized. MTT assay indicated that compounds 6, 8 and 11 exhibited inhibitory effect on LNCaP cells. Among these compounds, 4-(naphthalen-1-yl)-1-[1-(4-hydroxyphenyl)ethylidene)thiosemicarbazide (6), which caused more than 50% death on LNCaP cells, was chosen for flow cytometric analysis of apoptosis. Flow cytometric analysis pointed out that compound 6 also showed apoptotic effect on LNCaP cells. Compound 6 can be considered as a promising anticancer agent against LNCaP cells owing to its potent cytotoxic activity and apoptotic effect.
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Mehlika Dilek
authors.initials: MD
authors.lastname: Altintop
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Belgin
authors.initials: B
authors.lastname: Sever
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Ahmet
authors.initials: A
authors.lastname: Özdemir
authors.affiliation: b Open Education Faculty , Anadolu University , Eskişehir , Turkey .
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kuş
authors.affiliation: c Department of Biology, Faculty of Arts and Sciences , and.
authors.forename: Pinar
authors.initials: P
authors.lastname: Oztopcu-Vatan
authors.affiliation: d Department of Physiology, Faculty of Medicine , Eskisehir Osmangazi University , Eskişehir , Turkey.
authors.forename: Selda
authors.initials: S
authors.lastname: Kabadere
authors.affiliation: a Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Anadolu University , Eskişehir , Turkey .
authors.forename: Zafer Asim
authors.initials: ZA
authors.lastname: Kaplancikli
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes; D013882:Thiosemicarbazones; C031721:naphthalene
keywords: Apoptosis; LNCaP cells; naphthalene; thiosemicarbazone