title: Stem cell therapy for heart failure.
abstract: "During the past decade, studies in animals and humans have suggested that cell therapy has positive effects for the treatment of heart failure. This clinical effect may be mediated by angiogenesis and reduction in fibrosis rather than by regeneration of myocytes. Increased microvasculature and decreased scar also likely lead to improved cardiac function in the failing heart. The effects of cell therapy are not limited to one type of cell or delivery technique. Well-designed, large-scale, randomized clinical trials with objective end points will help to fully realize the therapeutic potential of cell-based therapy for treating heart failure."
authors.affiliation: University of Utah School of Medicine, 30 North 1900 East 3c127 SOM, Salt Lake City, UT 84132, USA. Electronic address: amit.patel@hsc.utah.edu.
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
authors.affiliation: University of Utah School of Medicine, 30 North 1900 East 3c127 SOM, Salt Lake City, UT 84132, USA.
authors.forename: Francisco
authors.initials: F
authors.lastname: Silva
authors.affiliation: University of Utah School of Medicine, 30 North 1900 East 3c127 SOM, Salt Lake City, UT 84132, USA.
authors.forename: Amalia A
authors.initials: AA
authors.lastname: Winters
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems / Q000379:methods; D005355:Fibrosis / Q000473:pathology / Q000628:therapy; D006333:Heart Failure / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006334:Heart Function Tests; D006801:Humans; D009206:Myocardium / Q000473:pathology*; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: Clinical trials; Delivery; Heart failure; Stem cell