title: Normal flora and bacterial vaginosis in pregnancy: an overview.
abstract: The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and predispose women to a potentially pathogenic microbiota. Bacteria that are associated with bacterial vaginosis (BV) are opportunistic pathogens that frequently form part of this microbiota. The overgrowth of and infections with these bacteria are linked to poor obstetric outcomes and increased transmission of other reproductive tract infections (RTIs). These infections increase women's susceptibility of acquiring HIV, the rates of HIV shedding and the development of acquired immune deficiency syndrome (AIDS) in HIV-infected patients. It is unknown how the plethora of bacterial species associated with BV contributes to the dynamics of this condition. The use of high-throughput methods have led to the in-depth investigation of different BV-related bacterial species and the functional capabilities of these species. However, the pathogenesis of BV is still poorly defined and the role of individual BV-related bacterial species in specific pregnancy complications is unclear and controversial. The majority of BV infections are asymptomatic and successful diagnosis is complicated by the lack of reliable and standardized diagnostic tests.
authors.affiliation: a Department of Medical Microbiology , University of Pretoria , Pretoria , South Africa and.
authors.forename: Mathys Jacobus
authors.initials: MJ
authors.lastname: Redelinghuys
authors.affiliation: a Department of Medical Microbiology , University of Pretoria , Pretoria , South Africa and.|b Department of Medical Microbiology , National Health Laboratory Service , Pretoria , South Africa.
authors.forename: Marthie Magdaleen
authors.initials: MM
authors.lastname: Ehlers
authors.affiliation: a Department of Medical Microbiology , University of Pretoria , Pretoria , South Africa and.|b Department of Medical Microbiology , National Health Laboratory Service , Pretoria , South Africa.
authors.forename: Andries William
authors.initials: AW
authors.lastname: Dreyer
authors.affiliation: a Department of Medical Microbiology , University of Pretoria , Pretoria , South Africa and.|b Department of Medical Microbiology , National Health Laboratory Service , Pretoria , South Africa.
authors.forename: Marleen Magdalena
authors.initials: MM
authors.lastname: Kock
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D064307:Microbiota; D011247:Pregnancy; D011248:Pregnancy Complications / Q000382:microbiology*; D016585:Vaginosis, Bacterial / Q000382:microbiology*
keywords: Bacterial vaginosis; microbiology; pregnancy; reproductive tract infections; vaginal microbiota