title: Urinary tract infections: treatment/comparative therapeutics.
abstract: Urinary tract infection (UTI) occurs when there is compromise of host defense mechanisms and a virulent microbe adheres, multiplies, and persists in a portion of the urinary tract. Most commonly, UTI is caused by bacteria, but fungi and viruses are possible. Urine culture and sensitivity are the gold standards for diagnosis of bacterial UTI. Identifying the location of infection (eg, bladder, kidney, prostate) as well as comorbidities (eg, diabetes mellitus, immunosuppression) is essential to guide the diagnostic and therapeutic plan. Antimicrobial agents are the mainstay of therapy for bacterial UTI and selected ideally based on culture and sensitivity.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA. Electronic address: solin@utk.edu.
authors.forename: Shelly J
authors.initials: SJ
authors.lastname: Olin
authors.affiliation: Cornell University Veterinary Specialists, 880 Canal Street, Stamford, CT 06902, USA.
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Bartges
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Canine; Cystitis; Feline; Prostatitis; Pyelonephritis; Urinary tract infection; Veterinary medicine
references.citation: J Am Vet Med Assoc. 2002 May 15;220(10):1496-8, 1474-5
references.pmid: 12018376
references.citation: J Microbiol Biotechnol. 2013 Mar;23(3):422-9
references.pmid: 23462017
references.citation: J Feline Med Surg. 2013 Oct;15(10):843-8
references.pmid: 23400682
references.citation: J Med Vet Mycol. 1986 Apr;24(2):95-104
references.pmid: 3723291
references.citation: Vet Microbiol. 2012 Aug 17;158(3-4):446-50
references.pmid: 22482718
references.citation: Vet Microbiol. 2009 Apr 14;136(1-2):130-4
references.pmid: 19056189
references.citation: J Am Vet Med Assoc. 2003 Oct 15;223(8):1156-8, 1129
references.pmid: 14584746
references.citation: J Vet Intern Med. 2013 Nov-Dec;27(6):1368-71
references.pmid: 24033665
references.citation: J Clin Microbiol. 2003 Jan;41(1):337-45
references.pmid: 12517870
references.citation: Nat Rev Urol. 2012 Apr 17;9(6):305-14
references.pmid: 22508462
references.citation: World J Microbiol Biotechnol. 2013 Feb;29(2):347-54
references.pmid: 23136054
references.citation: J Am Anim Hosp Assoc. 2002 Nov-Dec;38(6):541-4
references.pmid: 12428885
references.citation: J Am Vet Med Assoc. 1990 Oct 1;197(7):871-4
references.pmid: 2228770
references.citation: J Vet Intern Med. 2014 May-Jun;28(3):818-26
references.pmid: 24673608
references.citation: J Am Vet Med Assoc. 1985 Aug 15;187(4):384-8
references.pmid: 4030472
references.citation: J Vet Intern Med. 2001 Jul-Aug;15(4):341-7
references.pmid: 11467591
references.citation: Vet Microbiol. 2007 Mar 31;121(1-2):182-8
references.pmid: 17169507
references.citation: J Am Vet Med Assoc. 1971 Mar 15;158(6):721-8
references.pmid: 4929282
references.citation: Urology. 2011 Aug;78(2):341-6
references.pmid: 21683991
references.citation: J Vet Intern Med. 2003 Sep-Oct;17(5):622-31
references.pmid: 14529127
references.citation: J Vet Pharmacol Ther. 2013 Jun;36(3):209-21
references.pmid: 23406008
references.citation: J Am Anim Hosp Assoc. 2012 Nov-Dec;48(6):379-89
references.pmid: 23033458
references.citation: J Urol. 1987 Sep;138(3):491-4
references.pmid: 3625846
references.citation: J Am Vet Med Assoc. 2014 Jul 1;245(1):106-12
references.pmid: 24941394
references.citation: J Vet Intern Med. 2014 Mar-Apr;28(2):300-4
references.pmid: 24467326
references.citation: World J Urol. 2014 Feb;32(1):79-84
references.pmid: 23633128
references.citation: Vet Microbiol. 2006 Aug 25;116(1-3):246-7
references.pmid: 16815648
references.citation: J Urol. 2007 Jun;177(6):2357-60
references.pmid: 17509358
references.citation: Vet Radiol Ultrasound. 2006 Jan-Feb;47(1):90-3
references.pmid: 16429992
references.citation: Cochrane Database Syst Rev. 2007 Oct 17;(4):CD003265
references.pmid: 17943785
references.citation: J Vet Intern Med. 2012 May-Jun;26(3):506-12
references.pmid: 22486931
references.citation: J Feline Med Surg. 2007 Apr;9(2):124-32
references.pmid: 17088093
references.citation: BMC Microbiol. 2014 May 19;14:129
references.pmid: 24886369
references.citation: Int J Antimicrob Agents. 2006 Aug;28 Suppl 1:S42-8
references.pmid: 16829049
references.citation: J Am Anim Hosp Assoc. 1997 Mar-Apr;33(2):118-22
references.pmid: 9111720
references.citation: Doc Ophthalmol. 2008 May;116(3):177-91
references.pmid: 17909874
references.citation: Vet J. 2011 Oct;190(1):22-7
references.pmid: 21239193
references.citation: Eur J Obstet Gynecol Reprod Biol. 2008 Nov;141(1):54-7
references.pmid: 18701205
references.citation: Urol Res. 1992;20(6):403-7
references.pmid: 1462478
references.citation: J Vet Intern Med. 2013 Jan-Feb;27(1):39-46
references.pmid: 23140141
references.citation: Vet Clin North Am Small Anim Pract. 2004 Jul;34(4):923-33, vi
references.pmid: 15223209
references.citation: Clin Infect Dis. 2012 Nov 15;55(10):1400-7
references.pmid: 22828592
references.citation: BMC Vet Res. 2012 Nov 21;8:225
references.pmid: 23171620
references.citation: J Vet Intern Med. 2003 Jul-Aug;17(4):499-509
references.pmid: 12892301
references.citation: Vet Microbiol. 1998 Oct;63(2-4):109-16
references.pmid: 9850991
references.citation: J Feline Med Surg. 2013 Jun;15(6):459-65
references.pmid: 23232285
references.citation: Theriogenology. 2008 Aug;70(3):375-83
references.pmid: 18514299
references.citation: J Am Vet Med Assoc. 1975 Jun 15;166(12):1155-60
references.pmid: 1141031
references.citation: FEMS Microbiol Lett. 2007 Feb;267(1):30-7
references.pmid: 17166230
references.citation: Vet J. 2011 Jan;187(1):18-22
references.pmid: 20044282
references.citation: J Am Anim Hosp Assoc. 2005 Nov-Dec;41(6):373-81
references.pmid: 16267061
references.citation: Arch Intern Med. 2012 Jul 9;172(13):988-96
references.pmid: 22777630
references.citation: J Am Anim Hosp Assoc. 2003 May-Jun;39(3):263-70
references.pmid: 12755200
references.citation: Aust Vet J. 2014 Jan;92(1-2):33-7
references.pmid: 24471880
references.citation: J Vet Intern Med. 2007 Sep-Oct;21(5):990-5
references.pmid: 17939554
references.citation: Vet Pathol. 1985 Nov;22(6):540-7
references.pmid: 4082379
references.citation: Microb Drug Resist. 2014 Dec;20(6):575-82
references.pmid: 25050970
references.citation: J Feline Med Surg. 2011 Oct;13(10):800-3
references.pmid: 21856200
references.citation: Reprod Domest Anim. 2014 Jun;49 Suppl 2:8-15
references.pmid: 24947855
references.citation: Int J Antimicrob Agents. 2008 Feb;31 Suppl 1:S40-5
references.pmid: 18023152
references.citation: J Small Anim Pract. 1997 Jun;38(6):243-5
references.pmid: 9200113
references.citation: J Am Vet Med Assoc. 2004 Apr 15;224(8):1282-9
references.pmid: 15112776
references.citation: J Vet Med A Physiol Pathol Clin Med. 2006 Sep;53(7):379-82
references.pmid: 16922838
references.citation: J Am Vet Med Assoc. 1984 Jul 1;185(1):45-7
references.pmid: 6746370
references.citation: Vet Med Int. 2011;2011:263768
references.pmid: 21776346