title: Arabidopsis flower development--of protein complexes, targets, and transport.
abstract: Tremendous progress has been achieved over the past 25 years or more of research on the molecular mechanisms of floral organ identity, patterning, and development. While collections of floral homeotic mutants of Antirrhinum majus laid the foundation already at the beginning of the previous century, it was the genetic analysis of these mutants in A. majus and Arabidopsis thaliana that led to the development of the ABC model of floral organ identity more than 20 years ago. This intuitive model kick-started research focused on the genetic mechanisms regulating flower development, using mainly A. thaliana as a model plant. In recent years, interactions among floral homeotic proteins have been elucidated, and their direct and indirect target genes are known to a large extent. Here, we provide an overview over the advances in understanding the molecular mechanism orchestrating A. thaliana flower development. We focus on floral homeotic protein complexes, their target genes, evidence for their transport in floral primordia, and how these new results advance our view on the processes downstream of floral organ identity, such as organ boundary formation or floral organ patterning.
authors.affiliation: Institute of Botany, Justus-Liebig University, Heinrich-Buff-Ring 38, 35392, Gießen, Germany. annette.becker@bot1.bio.uni-giessen.de.
authors.forename: Annette
authors.initials: A
authors.lastname: Becker
authors.affiliation: Institute of Botany, Justus-Liebig University, Heinrich-Buff-Ring 38, 35392, Gießen, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Ehlers
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D035264:Flowers / Q000254:growth & development* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018506:Gene Expression Regulation, Plant; D005801:Genes, Homeobox; D017343:Genes, Plant; D026161:MADS Domain Proteins / Q000235:genetics / Q000378:metabolism; D046912:Multiprotein Complexes / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport
chemical_list: D029681:Arabidopsis Proteins; D026161:MADS Domain Proteins; D046912:Multiprotein Complexes
keywords: Arabidopsis thaliana; Floral homeotic genes; Flower development; MADS-box protein target genes; Protein complexes; Protein transport
references.citation: Plant Signal Behav. 2008 Oct;3(10):853-5
references.pmid: 19704520
references.citation: Nature. 2001 Jan 25;409(6819):469-71
references.pmid: 11206529
references.citation: Plant Physiol. 2008 Apr;146(4):1663-72
references.pmid: 18305206
references.citation: Cell. 2001 Jun 15;105(6):793-803
references.pmid: 11440721
references.citation: EMBO J. 1999 Oct 1;18(19):5370-9
references.pmid: 10508169
references.citation: Development. 2001 Jan;128(1):13-23
references.pmid: 11092807
references.citation: Development. 2010 Nov;137(21):3633-42
references.pmid: 20876650
references.citation: Science. 1995 Dec 22;270(5244):1980-3
references.pmid: 8533088
references.citation: Plant Cell. 2005 May;17(5):1424-33
references.pmid: 15805477
references.citation: J Exp Bot. 2006;57(12):3099-107
references.pmid: 16893974
references.citation: Development. 2010 Nov;137(22):3911-20
references.pmid: 20978082
references.citation: Science. 1999 Mar 19;283(5409):1911-4
references.pmid: 10082464
references.citation: Development. 1996 Jan;122(1):87-96
references.pmid: 8565856
references.citation: Plant Methods. 2006 Jun 26;2:12
references.pmid: 16800872
references.citation: Nucleic Acids Res. 2009 May;37(8):2723-36
references.pmid: 19276203
references.citation: Cell. 2001 Jun 15;105(6):805-14
references.pmid: 11440722
references.citation: Curr Opin Genet Dev. 2015 Jun;32:16-23
references.pmid: 25687790
references.citation: Genes Dev. 2004 Feb 15;18(4):375-80
references.pmid: 15004006
references.citation: Plant Cell. 1991 Aug;3(8):749-58
references.pmid: 1726485
references.citation: Development. 2005 Mar;132(5):897-911
references.pmid: 15673576
references.citation: Development. 2005 Feb;132(3):429-38
references.pmid: 15634696
references.citation: Dev Biol. 1996 Feb 25;174(1):22-31
references.pmid: 8626018
references.citation: Nucleic Acids Res. 2009 Jan;37(1):144-57
references.pmid: 19033361
references.citation: Genes Dev. 1996 Jul 15;10(14):1812-21
references.pmid: 8698240
references.citation: Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1560-5
references.pmid: 22238427
references.citation: Plant Cell. 2011 Oct;23(10):3654-70
references.pmid: 22028461
references.citation: Trends Biochem Sci. 2008 May;33(5):220-9
references.pmid: 18406148
references.citation: Development. 1998 Nov;125(21):4303-12
references.pmid: 9753684
references.citation: Front Plant Sci. 2014 Sep 16;5:465
references.pmid: 25278944
references.citation: Science. 2000 Jul 28;289(5479):617-9
references.pmid: 10915624
references.citation: Plant J. 2003 Jan;33(1):47-59
references.pmid: 12943540
references.citation: Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13452-7
references.pmid: 22847437
references.citation: Methods Mol Biol. 2014;1110:35-55
references.pmid: 24395251
references.citation: J Exp Bot. 2011 Oct;62(14):4719-30
references.pmid: 21914655
references.citation: Plant Cell. 1990 Aug;2(8):755-67
references.pmid: 2152125
references.citation: Front Plant Sci. 2011 Nov 21;2:79
references.pmid: 22645551
references.citation: Plant J. 2008 Feb;53(4):597-609
references.pmid: 18269571
references.citation: Plant Cell. 2008 Apr;20(4):901-19
references.pmid: 18441215
references.citation: Science. 2011 Aug 26;333(6046):1141-4
references.pmid: 21868675
references.citation: Plant J. 1996 Dec;10(6):967-79
references.pmid: 9011081
references.citation: Plant Cell. 2014 Sep;26(9):3603-15
references.pmid: 25228343
references.citation: Nature. 1996 Jan 4;379(6560):66-9
references.pmid: 8538741
references.citation: Mol Cells. 2011 Dec;32(6):519-26
references.pmid: 22080370
references.citation: Development. 1996 Nov;122(11):3433-41
references.pmid: 8951059
references.citation: Genome Biol. 2009 Feb 25;10(2):R24
references.pmid: 19243611
references.citation: Plant Cell. 2002 Oct;14(10):2463-79
references.pmid: 12368498
references.citation: J Exp Bot. 2014 Apr;65(7):1737-49
references.pmid: 24347464
references.citation: Genetics. 2003 Oct;165(2):821-33
references.pmid: 14573491
references.citation: Cell. 1992 May 29;69(5):843-59
references.pmid: 1350515
references.citation: New Phytol. 2013 Jun;198(4):1250-60
references.pmid: 23506539
references.citation: Plant Physiol. 2008 Jun;147(2):707-18
references.pmid: 18417639
references.citation: Curr Opin Plant Biol. 2012 Dec;15(6):645-51
references.pmid: 23031575
references.citation: Nature. 2000 May 11;405(6783):200-3
references.pmid: 10821278
references.citation: BMC Plant Biol. 2009 Jan 12;9:5
references.pmid: 19138429
references.citation: PLoS Biol. 2009 Apr 21;7(4):e1000090
references.pmid: 19385720
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11945-50
references.pmid: 16087887
references.citation: Plant J. 2014 Jan;77(1):1-15
references.pmid: 24164574
references.citation: Science. 2007 May 18;316(5827):1030-3
references.pmid: 17446353
references.citation: Development. 1996 May;122(5):1567-75
references.pmid: 8625843
references.citation: Protoplasma. 2011 Jan;248(1):61-74
references.pmid: 21174132
references.citation: J Exp Bot. 2014 Jan;65(1):1-9
references.pmid: 24277279
references.citation: Nature. 2001 Jan 25;409(6819):525-9
references.pmid: 11206550
references.citation: PLoS Genet. 2014 Dec 18;10(12):e1004856
references.pmid: 25521508
references.citation: Evodevo. 2010 Dec 01;1:13
references.pmid: 21122096
references.citation: Science. 1996 Nov 29;274(5292):1537-40
references.pmid: 8929416
references.citation: Development. 2012 Nov;139(22):4095-8
references.pmid: 23093420
references.citation: Science. 2014 Jan 31;343(6170):1248559
references.pmid: 24482483
references.citation: Genes Dev. 2005 Apr 1;19(7):788-93
references.pmid: 15805469
references.citation: Development. 1997 Oct;124(19):3835-44
references.pmid: 9367439
references.citation: Nature. 2003 Jul 3;424(6944):85-8
references.pmid: 12840762
references.citation: Science. 2005 Aug 12;309(5737):1056-9
references.pmid: 16099980
references.citation: Cell Mol Life Sci. 2012 Nov;69(22):3807-18
references.pmid: 22573183
references.citation: Plant J. 2009 Nov;60(4):626-37
references.pmid: 19656343
references.citation: Genetics. 2005 Apr;169(4):2209-23
references.pmid: 15687268
references.citation: Genome Biol. 2014 Mar 03;15(3):R41
references.pmid: 24581456
references.citation: Trends Plant Sci. 2006 May;11(5):224-31
references.pmid: 16616581
references.citation: Plant Cell. 2013 Feb;25(2):438-53
references.pmid: 23444328
references.citation: Science. 2004 Mar 26;303(5666):2022-5
references.pmid: 12893888
references.citation: Plant Cell. 2006 Jan;18(1):15-28
references.pmid: 16326928
references.citation: Development. 2006 Aug;133(16):3159-66
references.pmid: 16854969
references.citation: Plant Cell. 2007 Aug;19(8):2544-56
references.pmid: 17693535
references.citation: Proc Natl Acad Sci U S A. 1996 May 14;93(10):4793-8
references.pmid: 8643482
references.citation: Plant J. 2010 Jul 1;63(1):60-72
references.pmid: 20374529
references.citation: Development. 2003 Aug;130(16):3735-45
references.pmid: 12835390
references.citation: Plant Cell. 2013 Jul;25(7):2482-503
references.pmid: 23821642
references.citation: Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14619-24
references.pmid: 25246576
references.citation: Nucleic Acids Res. 2014;42(17):10927-42
references.pmid: 25183521
references.citation: Curr Biol. 2004 Nov 9;14(21):1935-40
references.pmid: 15530395
references.citation: Science. 2010 Apr 2;328(5974):85-9
references.pmid: 20360106
references.citation: Curr Opin Plant Biol. 2014 Feb;17:96-102
references.pmid: 24507500