title: Survival of Mexican children with acute myeloid leukaemia who received early intensification chemotherapy and an autologous transplant.
abstract: BACKGROUND
  In Mexico and other developing countries, few reports of the survival of children with acute leukaemia exist. Objective. We aimed at comparing the disease-free survival of children with acute myeloid leukaemia who, in addition to being treated with the Latin American protocol of chemotherapy and an autologous transplant, either underwent early intensified chemotherapy or did not undergo such treatment.
  
  
  METHODS
  This was a cohort study with a historical control group, forty patients, less than 16 years old. Group A (20 patients), diagnosed in the period 2005-2007, was treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy: high doses of cytarabine and mitoxantrone. Group B (20 patients), diagnosed in the period 1999-2004, was treated as Group A, but without the early intensified chemotherapy.
  
  
  RESULTS
  Relapse-free survival for Group A was 90% whereas that for Group B it was 60% (P = 0.041). Overall survival for Group A (18, 90%) was higher than that for Group B (60%). Complete remission continued for two years of follow-up.
  
  
  CONCLUSIONS
  Relapse-free survival for paediatric patients treated with the Latin American protocol of chemotherapy with an autologous transplant plus early intensified chemotherapy was higher than that for those who did not receive early intensified chemotherapy.
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Elva
authors.initials: E
authors.lastname: Jiménez-Hernández
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Dueñas-González
authors.affiliation: Laboratorio de Investigación, Hospital Infantil de México "Federico Gómez", Secretaría de Salud, Calle Doctor Marquez 162, Colonia Doctores, Delegación Cuauhtémoc, 06720 México, DF, Mexico.
authors.forename: José
authors.initials: J
authors.lastname: Arellano-Galindo
authors.affiliation: Hospital de Oncología, Centro Médico Nacional "Siglo XXI", IMSS, Avenida Cuauhtemoc 330, 06720 México, DF, Mexico.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Medrano-Ortíz-De-Zárate
authors.affiliation: Unidad de Investigación en Inmunología, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Vilma Carolina
authors.initials: VC
authors.lastname: Bekker-Méndez
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Adolfina
authors.initials: A
authors.lastname: Berges-García
authors.affiliation: Hematología Pediátrica, Centro Médico Nacional "Siglo XXI", IMSS, Avenida Cuauhtemoc 330, 06720 México, DF, Mexico.
authors.forename: Karina
authors.initials: K
authors.lastname: Solís-Labastida
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Berenice
authors.initials: B
authors.lastname: Sánchez-Jara
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Héctor Manuel
authors.initials: HM
authors.lastname: Tiznado-García
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Ethel Zulie
authors.initials: EZ
authors.lastname: Jaimes-Reyes
authors.affiliation: Facultad de Medicina, Universidad Nacional Autónoma de México, Avenida Universidad 3000, 04510 México, DF, Mexico.
authors.forename: Xochiketzalli
authors.initials: X
authors.lastname: García-Jiménez
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Espinoza-Hernández
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Nora Nancy
authors.initials: NN
authors.lastname: Núñez-Villegas
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Sergio
authors.initials: S
authors.lastname: Franco-Ornelas
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Ruy Xavier
authors.initials: RX
authors.lastname: Pérez-Casillas
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Octavio Martínez
authors.initials: OM
authors.lastname: Villegas
authors.affiliation: Departamento de Hematología Pediátrica, Unidad Médica de Alta Especialidad (UMAE), Centro Médico Nacional "La Raza", Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo, S/N, Colonia La Raza, 02990 México, DF, Mexico.
authors.forename: Teresa Marin
authors.initials: TM
authors.lastname: Palomares
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, UMAE Hospital de Pediatría, Centro Médico Nacional "Siglo XXI", IMSS, Avenida Cuauhtemoc 330, 4to Piso Edificio de la Academia Nacional de Medicina, 06720 México, DF, Mexico.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Mejía-Aranguré
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000401:mortality* / Q000628:therapy*; D008137:Longitudinal Studies; D008297:Male; D008800:Mexico / Q000453:epidemiology; D012307:Risk Factors; D033581:Stem Cell Transplantation / Q000401:mortality* / Q000706:statistics & numerical data*; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents
references.citation: Blood. 2008 Feb 1;111(3):1044-53
references.pmid: 18000167
references.citation: Bone Marrow Transplant. 2007 Aug;40(4):313-8
references.pmid: 17563741
references.citation: Leuk Lymphoma. 2009 Jul;50(7):1132-7
references.pmid: 19557634
references.citation: J Clin Oncol. 2010 Jun 1;28(16):2682-9
references.pmid: 20439630
references.citation: J Clin Oncol. 2010 Jun 1;28(16):2674-81
references.pmid: 20439644
references.citation: Blood. 2010 Sep 30;116(13):2205-14
references.pmid: 20538803
references.citation: Curr Opin Oncol. 2010 Nov;22(6):646-55
references.pmid: 20805748
references.citation: Bone Marrow Transplant. 2011 Mar;46(3):385-92
references.pmid: 20479710
references.citation: J Clin Oncol. 2001 May 15;19(10):2705-13
references.pmid: 11352963
references.citation: Br J Haematol. 2002 Jun;117(4):907-13
references.pmid: 12060130
references.citation: Int J Hematol. 2002 Aug;76 Suppl 1:380-2
references.pmid: 12430886
references.citation: Blood. 2003 Feb 15;101(4):1611-9
references.pmid: 12393725
references.citation: Haematologica. 2003 Mar;88(3):290-9
references.pmid: 12651268
references.citation: J Clin Oncol. 2003 Dec 15;21(24):4642-9
references.pmid: 14673054
references.citation: J Clin Oncol. 2004 Nov 1;22(21):4384-93
references.pmid: 15514380
references.citation: N Engl J Med. 1986 Jul 17;315(3):141-7
references.pmid: 3523241
references.citation: Br J Haematol. 1987 Jul;66(3):285-8
references.pmid: 2887196
references.citation: Leukemia. 1990 Mar;4(3):177-83
references.pmid: 2179638
references.citation: Leukemia. 1992;6 Suppl 2:59-62
references.pmid: 1578943
references.citation: Blood. 1994 Mar 15;83(6):1698-705
references.pmid: 8123862
references.citation: N Engl J Med. 1994 Oct 6;331(14):896-903
references.pmid: 8078551
references.citation: J Pediatr Hematol Oncol. 1995 May;17(2):94-100
references.pmid: 7749772
references.citation: N Engl J Med. 1996 May 30;334(22):1428-34
references.pmid: 8618581
references.citation: J Clin Oncol. 1996 Aug;14(8):2206-16
references.pmid: 8708709
references.citation: Bone Marrow Transplant. 1998 Feb;21(4):375-82
references.pmid: 9509972
references.citation: Am J Hematol. 1998 Jul;58(3):161-4
references.pmid: 9662265
references.citation: Br J Haematol. 1999 Mar;104(3):630-9
references.pmid: 10086807
references.citation: Blood. 1999 Jun 15;93(12):4116-24
references.pmid: 10361108
references.citation: Br J Haematol. 2005 May;129(3):403-10
references.pmid: 15842665
references.citation: Pediatr Blood Cancer. 2005 Jun 15;44(7):654-9
references.pmid: 15700262
references.citation: Pediatr Hematol Oncol. 2005 Oct-Nov;22(7):597-608
references.pmid: 16166053
references.citation: Leukemia. 2005 Dec;19(12):2117-24
references.pmid: 16107894
references.citation: Leukemia. 2005 Dec;19(12):2063-71
references.pmid: 16107896
references.citation: Leukemia. 2005 Dec;19(12):2043-53
references.pmid: 16107897
references.citation: Leukemia. 2005 Dec;19(12):2082-9
references.pmid: 16121218
references.citation: Leukemia. 2005 Dec;19(12):2072-81
references.pmid: 16136166
references.citation: Leukemia. 2005 Dec;19(12):2101-16
references.pmid: 16136167
references.citation: Leukemia. 2005 Dec;19(12):2054-62
references.pmid: 16136168
references.citation: Leukemia. 2005 Dec;19(12):2125-9
references.pmid: 16281077
references.citation: Leukemia. 2005 Dec;19(12):2025-9
references.pmid: 16304569
references.citation: Leukemia. 2005 Dec;19(12):2030-42
references.pmid: 16304570
references.citation: Leukemia. 2005 Dec;19(12):2090-100
references.pmid: 16304571
references.citation: Blood. 2001 Jan 1;97(1):56-62
references.pmid: 11133742
references.citation: Leukemia. 2005 Dec;19(12):2130-8
references.pmid: 16304572
references.citation: Leukemia. 2005 Dec;19(12):2139-42
references.pmid: 16304573
references.citation: Leukemia. 2005 Dec;19(12):2143-6
references.pmid: 16304574
references.citation: Biol Blood Marrow Transplant. 2006 Feb;12(2):204-16
references.pmid: 16443518
references.citation: Acta Med Port. 2005 Sep-Oct;18(5):329-37
references.pmid: 16611537
references.citation: J Clin Oncol. 2008 Dec 10;26(35):5797-801
references.pmid: 18955460