title: An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene C(sp(3))-H bond insertion.
abstract: A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation.
authors.affiliation: School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou, Jiangsu Province 213164, China. meihuashen@gmail.com huadongxu@gmail.com.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Shen
authors.forename: Ying-Peng
authors.initials: YP
authors.lastname: Pan
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jia
authors.forename: Xin-Tao
authors.initials: XT
authors.lastname: Ren
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Xu
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; C030011:carbene; D012238:Rhodium; D008697:Methane