title: miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP.
abstract: MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR-889 in cancers. Here, we report that over-expression of miR-889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S-phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR-889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR-889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR-889 is an important regulator in ESCC and both miR-889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC.
authors.affiliation: Department of Clinical Laboratory Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
authors.forename: Yanting
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Central Laboratory, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
authors.forename: Jiangtu
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Clinical Laboratory Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratory Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
authors.forename: Xinyi
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Central Laboratory, Tenth People's Hospital of Tongji University, Shanghai 200072, China. Electronic address: labpqh@163.com.
authors.forename: Qiuhui
authors.initials: Q
authors.lastname: Pan
authors.affiliation: College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: xieqiuling098@163.com.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Clinical Laboratory Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China. Electronic address: labsfy@163.com.
authors.forename: Fenyong
authors.initials: F
authors.lastname: Sun
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D015972:Gene Expression Regulation, Neoplastic; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C462952:DAB2IP protein, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D020703:ras GTPase-Activating Proteins
keywords: Cell proliferation; DAB2IP; Esophageal squamous cell carcinoma; miR-889