title: Progressive outer retinal necrosis in immunocompromised kidney allograft recipient.
abstract: Ocular complications in patients who underwent renal transplantation are attributed to side effects of the immunosuppressive regimen. Progressive outer retinal necrosis (PORN) syndrome is a clinical variant of necrotizing herpetic retinopathy and it occurs almost exclusively in patients with acquired immunodeficiency syndrome. We present a case of a human immunodeficiency virus-negative patient who underwent renal transplant and, after a few years, developed bilateral PORN associated with viral infections. Varicella zoster virus (VZV) and BK virus were identified by polymerase chain reaction from the vitreous fluid. It is unclear which of the viruses identified had the dominant role in the pathogenesis of PORN and other organ damage, or whether their actions were synergistic. Adequate antiviral immune surveillance, as well as pre-transplant vaccination against VZV, may reduce the incidence of VZV infection and its complications.
authors.affiliation: Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Turno-Kręcicka
authors.affiliation: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Boratyńska
authors.affiliation: Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Tomczyk-Socha
authors.affiliation: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland.
authors.forename: O
authors.initials: O
authors.lastname: Mazanowska
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D064591:Allografts; D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use*; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D058449:Intravitreal Injections; D016030:Kidney Transplantation / Q000009:adverse effects*; D009336:Necrosis; D009894:Opportunistic Infections; D012173:Retinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir
keywords: BK virus; PORN; kidney transplant; progressive outer retinal necrosis syndrome; varicella zoster virus