title: Functional diversity of the superfamily of K⁺ transporters to meet various requirements.
abstract: The superfamily of K+ transporters unites proteins from plants, fungi, bacteria, and archaea that translocate K+ and/or Na+ across membranes. These proteins are key components in osmotic regulation, pH homeostasis, and resistance to high salinity and dryness. The members of the superfamily are closely related to K+ channels such as KcsA but also show several striking differences that are attributed to their altered functions. This review highlights these functional differences, focusing on the bacterial superfamily members KtrB, TrkH, and KdpA. The functional variations within the family and comparison to MPM-type K+ channels are discussed in light of the recently solved structures of the Ktr and Trk systems.
authors.forename: Marina
authors.initials: M
authors.lastname: Diskowski
authors.forename: Vedrana
authors.initials: V
authors.lastname: Mikusevic
authors.forename: Charlott
authors.initials: C
authors.lastname: Stock
authors.forename: Inga
authors.initials: I
authors.lastname: Hänelt
mesh_terms: D000818:Animals; D006801:Humans; D008958:Models, Molecular; D015221:Potassium Channels / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015221:Potassium Channels