title: Evaluation of a combination chemotherapy protocol including lomustine and doxorubicin in canine histiocytic sarcoma.
abstract: OBJECTIVE
  To describe a chemotherapy protocol combining lomustine and doxorubicin in canine histiocytic sarcoma, including outcomes and toxicity.
  
  
  METHODS
  Retrospective review of case records for dogs with histiocytic sarcoma treated with lomustine and doxorubicin (± cyclophosphamide) alternating every 2 weeks. Data collected included signalment, clinical signs, clinicopathological abnormalities, extent of disease, response, toxicity, time to tumour progression and survival time.
  
  
  RESULTS
  Of 17 dogs, 15 had disseminated or metastatic disease. The median number of chemotherapy cycles (one dose of each drug) received was three; most dogs discontinued therapy due to progressive disease. Dose reductions or delays occurred in 18% of cycles. The overall response rate was 58%, with a median time to tumour progression of 185 (range, 59 to 268) days for responders. The overall median survival time was 185 (18 to 402) days. No significant prognostic factors were identified.
  
  
  CONCLUSIONS
  The protocol appeared well-tolerated, had some efficacy against canine histiocytic sarcoma in the study population and could be considered as an alternative to single-agent protocols; prospective comparison may be warranted.
authors.affiliation: Veterinary Clinical Sciences Department, University of Minnesota, St Paul, MN, 55108, USA.
authors.forename: C
authors.initials: C
authors.lastname: Cannon
authors.affiliation: Veterinary Clinical Sciences Department, University of Minnesota, St Paul, MN, 55108, USA.
authors.forename: A
authors.initials: A
authors.lastname: Borgatti
authors.affiliation: Veterinary Clinical Sciences Department, University of Minnesota, St Paul, MN, 55108, USA.
authors.forename: M
authors.initials: M
authors.lastname: Henson
authors.affiliation: Veterinary Clinical Sciences Department, University of Minnesota, St Paul, MN, 55108, USA.
authors.forename: B
authors.initials: B
authors.lastname: Husbands
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols; D004283:Dog Diseases / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage*; D005260:Female; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000662:veterinary*; D008130:Lomustine / Q000008:administration & dosage*; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D008130:Lomustine; D004317:Doxorubicin