title: Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy.
abstract: Magnetic nanoparticles (MNPs), referred to as the Dartmouth MNPs, which exhibit high specific absorption rate at low applied field strength have been developed for hyperthermia therapy applications. The MNPs consist of small (2-5 nm) single crystals of gamma-Fe2O3with saccharide chains implanted in their crystalline structure, forming 20-40 nm flower-like aggregates with a hydrodynamic diameter of 110-120 nm. The MNPs form stable (>12 months) colloidal solutions in water and exhibit no hysteresis under an applied quasistatic magnetic field, and produce a significant amount of heat at field strengths as low as 100 Oe at 99-164 kHz. The MNP heating mechanisms under an alternating magnetic field (AMF) are discussed and analyzed quantitatively based on (a) the calculated multi-scale MNP interactions obtained using a three dimensional numerical model called the method of auxiliary sources, (b) measured MNP frequency spectra, and (c) quantified MNP friction losses based on magneto-viscous theory. The frequency responses and hysteresis curves of the Dartmouth MNPs are measured and compared to the modeled data. The specific absorption rate of the particles is measured at various AMF strengths and frequencies, and compared to commercially available MNPs. The comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe). This may extend MNP hyperthermia therapy to deeper tumors that were previously non-viable targets, potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.
authors.affiliation: Thayer School of Engineering at Dartmouth College , 14 Engineering Drive, Hanover, New Hampshire 03755, USA.
authors.forename: Fridon
authors.identifier: 0000-0001-9674-4810
authors.initials: F
authors.lastname: Shubitidze
authors.affiliation: Thayer School of Engineering at Dartmouth College , 14 Engineering Drive, Hanover, New Hampshire 03755, USA.
authors.forename: Katsiaryna
authors.identifier: 0000-0002-3739-5259
authors.initials: K
authors.lastname: Kekalo
authors.affiliation: Thayer School of Engineering at Dartmouth College , 14 Engineering Drive, Hanover, New Hampshire 03755, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Stigliano
authors.affiliation: Thayer School of Engineering at Dartmouth College , 14 Engineering Drive, Hanover, New Hampshire 03755, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Baker
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