title: Exploratory clinical trial to evaluate the efficacy of a topical traditional chinese herbal medicine in psoriasis vulgaris.
abstract: Objective. To evaluate the efficacy and safety of herbal ointment, Shi Du Ruan Gao, in patients with plaque-type psoriasis. Design. Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study. Participants. One hundred outpatients with mild to moderate chronic plaque-type psoriasis were enrolled. Intervention. The patients applied either Shi Du Ruan Gao ointment or vehicle ointment topically to for 8 weeks. Main Outcome Measures. The outcomes were assessed using the following criteria: Total Severity Score (TSS, sum of erythema, scaling, and plaque elevation/induration, on a 0 to 4 scale), Investigator Global Assessment (IGA) evaluated on a 0 (Clear) to 4 (s to very severe) scale, and Global Subjects' Assessment of treatment response on a 7-point scale from -1 (worse) to 5 (Cleared). Results. Significant reductions in the Total Severity Score (P < 0.001) (mean score: 2.7 after Shi Du Ruan Gao treatment versus 5.1 in control subjects). Both Investigator Global Assessment (IGA) and Global Subjects' Assessment of treatment are better in the Shi Du Ruan Gao group than the control group (P < 0.001). Conclusion. Shi Du Ruan Gao ointment was a safe, and effective therapy for plaque-type psoriasis.
authors.affiliation: Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, 100053 Beijing, China.
authors.forename: Yuhe
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Dermatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, 100053 Beijing, China.
authors.forename: Wali
authors.initials: W
authors.lastname: Liu
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Andres
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Colette
authors.initials: C
authors.lastname: Pernin
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Chantalat
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Briantais
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Albert
authors.initials: A
authors.lastname: Lin
authors.affiliation: Galderma R&D, Les Templiers, 2400 route des Colles, BP 87, 06902 Sophia Antipolis Cedex, France.
authors.forename: Lilian
authors.initials: L
authors.lastname: Feng
references.citation: Biochem Pharmacol. 2004 Jan 1;67(1):167-74
references.pmid: 14667939
references.citation: Zhong Xi Yi Jie He Xue Bao. 2006 Nov;4(6):624-7
references.pmid: 17090381
references.citation: Zhongguo Zhong Yao Za Zhi. 2005 Nov;30(21):1685-8
references.pmid: 16400949
references.citation: Molecules. 2007 Feb 06;12 (2):155-62
references.pmid: 17846565
references.citation: Int Immunopharmacol. 2014 Apr;19(2):214-20
references.pmid: 24503166
references.citation: Arch Dermatol. 2011 May;147(5):627-9
references.pmid: 21576591
references.citation: Dermatology. 2011;223(3):239-43
references.pmid: 22056841
references.citation: Dermatology. 2007;214(2):155-61
references.pmid: 17341866
references.citation: Arch Dermatol. 2008 Nov;144(11):1457-64
references.pmid: 19015420