title: [The ability of the natural ketones to interact with bacterial quorum sensing systems].
abstract: The effect of the natural ketones emitted by bacteria (2-nonanone, 2-heptanone, 2-undecanone) on the functioning of the Quorum Sensing (QS) systems was studied. In this work, three lux-reporter strains containing the components of the LasI/LasR, RhlI/RhlR, LuxI LuxR QS systems were used as biosensors for the N-acyl-homoserine lactones. It was shown that at concentrations of ketones that exhibited little or no bactericidal action the ketones could modulate the QS-response by suppressing the expression of the lux-operon reporter to a greater extent than the cell viability of these strains.
authors.forename: V A
authors.initials: VA
authors.lastname: Pliuta
authors.forename: F F
authors.initials: FF
authors.lastname: Popova
authors.forename: O A
authors.initials: OA
authors.lastname: Koksharova
authors.forename: A E
authors.initials: AE
authors.lastname: Kuznetsov
authors.forename: I A
authors.initials: IA
authors.lastname: khmel'
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D015374:Biosensing Techniques; D004926:Escherichia coli / Q000235:genetics*; D007659:Ketones / Q000378:metabolism*; D008025:Ligases / Q000235:genetics; D053038:Quorum Sensing / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D007659:Ketones; C081237:LasI protein, Pseudomonas aeruginosa; C085427:LuxI protein, Bacteria; D012097:Repressor Proteins; C086515:RhlR protein, Pseudomonas aeruginosa; D015534:Trans-Activators; D014157:Transcription Factors; C064778:LuxR autoinducer binding proteins; C011917:2-heptanone; D008025:Ligases; C096955:RHLI protein, Pseudomonas aeruginosa; C526928:undecan-2-one; C026636:2-nonanone