title: Cytotoxic indole alkaloids from the fruits of Melodinus cochinchinensis.
abstract: Eight indole alkaloids, melosines A-H, together with 13 known alkaloids, were isolated from the fruits of Melodinus cochinchinensis. The structure elucidation of isolated secondary metabolites was based on comprehensive spectroscopic data analysis. Melosine B showed moderate cytotoxic activity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW480 with IC50 values ranging from 1.6 to 8.1μM.
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Shun
authors.initials: S
authors.lastname: Shao
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Hai-Yuan
authors.initials: HY
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ding
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China. Electronic address: tempzhao@126.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Yunnan University of TCM, Kunming 650500, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: hehongping@mail.kib.ac.cn.
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029062:Apocynaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; C000605025:melosine B
keywords: Apocynaceae; Cytotoxicity; Indole alkaloids; Melodinus cochinchinensis