title: Expanding roles for AMPK in skeletal muscle plasticity.
abstract: Skeletal muscle possesses a remarkable plasticity and responds to environmental and physiological challenges by changing its phenotype in terms of size, composition, and metabolic properties. Muscle fibers rapidly adapt to drastic changes in energy demands during exercise through fine-tuning of the balance between catabolic and anabolic processes. One major sensor of energy demand in exercising muscle is AMP-activated protein kinase (AMPK). Recent advances have shed new light on the relevance of AMPK both as a multitask gatekeeper and as an energy regulator in skeletal muscle. Here we summarize recent findings on the function of AMPK in skeletal muscle adaptation to contraction and highlight its role in the regulation of energy metabolism and the control of skeletal muscle regeneration post-injury.
authors.affiliation: Centre de Génétique et de Physiologie Moléculaires et Cellulaires, UMR CNRS 5534, Villeurbanne, France; Université Claude Bernard Lyon 1, Villeurbanne, France.
authors.forename: Rémi
authors.initials: R
authors.lastname: Mounier
authors.affiliation: Centre de Génétique et de Physiologie Moléculaires et Cellulaires, UMR CNRS 5534, Villeurbanne, France; Université Claude Bernard Lyon 1, Villeurbanne, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: Marine
authors.initials: M
authors.lastname: Théret
authors.affiliation: Vanderbilt University Medical Center, Molecular Physiology and Biophysics, Nashville, TN, USA.
authors.forename: Louise
authors.initials: L
authors.lastname: Lantier
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris, France; INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Foretz
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Paris, France; INSERM, U1016, Institut Cochin, Paris, France; CNRS, UMR8104, Paris, France. Electronic address: benoit.viollet@inserm.fr.
authors.forename: Benoit
authors.initials: B
authors.lastname: Viollet
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D015444:Exercise / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D009135:Muscular Diseases / Q000201:enzymology / Q000378:metabolism
chemical_list: D055372:AMP-Activated Protein Kinases
keywords: AMP-activated protein kinase; exercise; muscular diseases; regeneration; skeletal muscle; therapeutics