title: Comparison of Two Deformable Registration Algorithms in the Presence of Radiologic Change Between Serial Lung CT Scans.
abstract: We evaluated the image registration accuracy achieved using two deformable registration algorithms when radiation-induced normal tissue changes were present between serial computed tomography (CT) scans. Two thoracic CT scans were collected for each of 24 patients who underwent radiation therapy (RT) treatment for lung cancer, eight of whom experienced radiologically evident normal tissue damage between pre- and post-RT scan acquisition. For each patient, 100 landmark point pairs were manually placed in anatomically corresponding locations between each pre- and post-RT scan. Each post-RT scan was then registered to the pre-RT scan using (1) the Plastimatch demons algorithm and (2) the Fraunhofer MEVIS algorithm. The registration accuracy for each scan pair was evaluated by comparing the distance between landmark points that were manually placed in the post-RT scans and points that were automatically mapped from pre- to post-RT scans using the displacement vector fields output by the two registration algorithms. For both algorithms, the registration accuracy was significantly decreased when normal tissue damage was present in the post-RT scan. Using the Plastimatch algorithm, registration accuracy was 2.4 mm, on average, in the absence of radiation-induced damage and 4.6 mm, on average, in the presence of damage. When the Fraunhofer MEVIS algorithm was instead used, registration errors decreased to 1.3 mm, on average, in the absence of damage and 2.5 mm, on average, when damage was present. This work demonstrated that the presence of lung tissue changes introduced following RT treatment for lung cancer can significantly decrease the registration accuracy achieved using deformable registration.
authors.affiliation: Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., MC 2026, Chicago, IL, 60637, USA.
authors.forename: Alexandra R
authors.initials: AR
authors.lastname: Cunliffe
authors.affiliation: Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., MC 2026, Chicago, IL, 60637, USA.
authors.forename: Bradley
authors.initials: B
authors.lastname: White
authors.affiliation: Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., MC 2026, Chicago, IL, 60637, USA.
authors.forename: Julia
authors.initials: J
authors.lastname: Justusson
authors.affiliation: Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., MC 2026, Chicago, IL, 60637, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Straus
authors.affiliation: Department of Radiation & Cellular Oncology, The University of Chicago, 5758 S. Maryland Ave., Chicago, IL, 60637, USA.
authors.forename: Renuka
authors.initials: R
authors.lastname: Malik
authors.affiliation: Department of Radiation & Cellular Oncology, The University of Chicago, 5758 S. Maryland Ave., Chicago, IL, 60637, USA.
authors.forename: Hania A
authors.initials: HA
authors.lastname: Al-Hallaq
authors.affiliation: Department of Radiology, The University of Chicago, 5841 S. Maryland Ave., MC 2026, Chicago, IL, 60637, USA. s-armato@uchicago.edu.
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Armato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D015203:Reproducibility of Results; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
keywords: Chest CT; Image registration; Lung; Radiotherapy
references.citation: Phys Med Biol. 2009 Apr 7;54(7):1849-70
references.pmid: 19265208
references.citation: Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):97-103
references.pmid: 21543163
references.citation: Acta Oncol. 2011 May;50(4):509-17
references.pmid: 21174519
references.citation: Med Phys. 2003 May;30(5):979-85
references.pmid: 12773007
references.citation: IEEE Trans Med Imaging. 2011 Nov;30(11):1901-20
references.pmid: 21632295
references.citation: Med Phys. 2013 Jun;40(6):061906
references.pmid: 23718597
references.citation: Phys Med Biol. 2010 Jan 7;55(1):305-27
references.pmid: 20009196
references.citation: Chest. 1997 Apr;111(4):1061-76
references.pmid: 9106589
references.citation: Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):583-96
references.pmid: 19910137
references.citation: Med Image Anal. 2011 Feb;15(1):71-84
references.pmid: 20709592
references.citation: Phys Med Biol. 2007 Oct 7;52(19):5771-83
references.pmid: 17881799
references.citation: Phys Med Biol. 2014 Sep 21;59(18):5387-98
references.pmid: 25157625
references.citation: Med Phys. 2012 Aug;39(8):4679-90
references.pmid: 22894392