title: Optical measurement of mouse strain differences in cerebral blood flow using indocyanine green.
abstract: C57BL/6 mice have more cerebral arterial branches and collaterals than BALB/c mice. We measured and compared blood flow dynamics of the middle cerebral artery (MCA) in these two strains, using noninvasive optical imaging with indocyanine green (ICG). Relative maximum fluorescence intensity (Imax) and the time needed for ICG to reach Imax in the MCA of C57BL/c were lower than that in BALB/c mice. Moreover, the mean transit time was significantly lower in C57BL/6 than in BALB/c mice. These data suggest that the higher number of arterial branches and collaterals in C57BL/6 mice yields a lower blood flow per cerebral artery.
authors.affiliation: Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Hye-Min
authors.initials: HM
authors.lastname: Kang
authors.affiliation: Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Inkyung
authors.initials: I
authors.lastname: Sohn
authors.affiliation: R&D Center, Vieworks Co., Ltd., Anyang, Korea.
authors.forename: Seunggyu
authors.initials: S
authors.lastname: Kim
authors.affiliation: R&D Center, Vieworks Co., Ltd., Anyang, Korea.
authors.forename: Daehwan
authors.initials: D
authors.lastname: Kim
authors.affiliation: Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Junyang
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Jeong
authors.affiliation: Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Chan
authors.initials: C
authors.lastname: Park
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation; D007208:Indocyanine Green / Q000032:analysis*; D008297:Male; D008807:Mice, Inbred BALB C / Q000502:physiology*; D008810:Mice, Inbred C57BL / Q000502:physiology*; D020768:Middle Cerebral Artery / Q000502:physiology*; D061848:Optical Imaging / Q000379:methods
chemical_list: D007208:Indocyanine Green
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