title: Dynamic Kinetic Asymmetric Amination of Alcohols: From A Mixture of Four Isomers to Diastereo- and Enantiopure α-Branched Amines.
abstract: The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology is presented. Under the cooperative catalysis by an iridium complex and a chiral phosphoric acid, α-branched alcohols that exist as a mixture of four isomers undergo racemization by two orthogonal mechanisms and are converted to diastereo- and enantiopure amines bearing adjacent stereocenters. The preparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic system.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Rong
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Raymond Hong Bing
authors.initials: RH
authors.lastname: Chua
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Hui-Jie
authors.initials: HJ
authors.lastname: Pan
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore, 117543.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao