title: Crystal structure of 1-(2-chloro-acet-yl)-3,3-dimethyl-2,6-di-p-tolyl-piperidin-4-one.
abstract: In the title compound, C23H26ClNO2, the piperidin-4-one ring adopts a distorted boat conformation. The two p-tolyl rings are nearly normal to each other, making a dihedral angle of 83.33 (10)°. They are inclined to the mean plane of the piperidine ring by 73.2 (1) and 87.22 (9)°. In the crystal, there are no significant inter-molecular inter-actions present.
authors.affiliation: Drug Discovery Lab., Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India.
authors.forename: S
authors.initials: S
authors.lastname: Jothivel
authors.affiliation: Division of Life Sciences, Central Instrumentation Facility, Institute of Advanced Study in Science & Technology (IASST), Guwahati 781 035, Assam, India.
authors.forename: Jibon
authors.initials: J
authors.lastname: Kotoky
authors.affiliation: Drug Discovery Lab., Department of Chemistry, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India.
authors.forename: S
authors.initials: S
authors.lastname: Kabilan
keywords: crystal structure; p-tol­yl; piperidin-4-one; piperidones
references.citation: Bioorg Med Chem Lett. 2009 Jun 1;19(11):2981-5
references.pmid: 19419867
references.citation: Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55
references.pmid: 19171970
references.citation: J Med Chem. 2001 Feb 15;44(4):586-93
references.pmid: 11170648
references.citation: Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22
references.pmid: 18156677
references.citation: Spectrochim Acta A Mol Biomol Spectrosc. 2007 Dec 31;68(5):1153-63
references.pmid: 17468043