title: Antibacterial and antifungal activities of various solvent extracts from the leaves and stem bark of Anisophyllea laurina R. Br ex Sabine used as traditional medicine in Guinea.
abstract: BACKGROUND
  Anisophyllea laurina R. Br ex Sabine is a plant that has been used in the folk medicine to treat malaria, dysentery, diabetes and toothache against bacterial infection. Through this study, most likely we are reporting for the first time, its effectiveness as an antibacterial and antifungal agent.
  
  
  OBJECTIVE
  To evaluate antibacterial and antifungal activities of various solvent extracts from the leaves and stem bark of A. laurina R. Br ex Sabine.
  
  
  METHODS
  The various solvent extracts of leaves and stem bark were tested for antibacterial and antifungal activities against eight bacteria strains and three fungal strains using the well diffusion and micro-dilution methods.
  
  
  RESULTS
  Antibacterial and antifungal activities of methanol and ethanol extracts were higher than the ethyl acetate and water extract. Leaves extracts had the highest potential activity against bacteria than stem bark extracts, but showed low antifungal activity compared to stem bark extracts. They also exhibited potent growth inhibitory activity against Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli ATCC 8739 and Bacillus subtilis with MIC value of 125µg/mL.
  
  
  CONCLUSIONS
  The current study confirmed that the leaves and stem bark extracts of A. laurina R. Br ex Sabine proved to be most effective as antibacterial and antifungal activities.
authors.affiliation: Center of Excellence for Functional Food and Health, School of Food Science and Technology, Jiangnan University, ChinaJiangnan University, Wuxi China.
authors.forename: Gbago
authors.initials: G
authors.lastname: Onivogui
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, China.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Diaby
authors.affiliation: Center of Excellence for Functional Food and Health, School of Food Science and Technology, Jiangnan University, ChinaJiangnan University, Wuxi China; State Key Laboratory of Food Science and Technology, Jiangnan University, China.
authors.forename: Xiaotian
authors.initials: X
authors.lastname: Chen
authors.affiliation: Center of Excellence for Functional Food and Health, School of Food Science and Technology, Jiangnan University, ChinaJiangnan University, Wuxi China.
authors.forename: Huaiyuan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, China.
authors.forename: M'balu Regina
authors.initials: MR
authors.lastname: Kargbo
authors.affiliation: Center of Excellence for Functional Food and Health, School of Food Science and Technology, Jiangnan University, ChinaJiangnan University, Wuxi China; State Key Laboratory of Food Science and Technology, Jiangnan University, China. Electronic address: ysong@jiangnan.edu.cn.
authors.forename: Yuanda
authors.initials: Y
authors.lastname: Song
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D016701:Guinea; D019684:Magnoliopsida; D008519:Medicine, Traditional; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D012997:Solvents / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D012997:Solvents
keywords: Anisophyllea laurina R. Br ex Sabine; Antibacterial activity; Antifungal activity; Leaves; Stem bark