title: Mechanical properties and cytotoxicity of nanoplate-like hydroxyapatite/polylactide nanocomposites prepared by intercalation technique.
abstract: Hydroxyapatite (HAp) in the forms of fiber, needle, and whisker has been employed as fillers in polymer composites. Herein, nanoplate-like HAp synthesized by template-assisted self-assembly was used to reinforce polylactide (PLA) nanocomposites via the solution intercalation method. Dynamic and static mechanical properties and cytotoxicity of the as-prepared HAp/PLA nanocomposites were assessed in addition to characterizations by XRD, FTIR, and TGA. XRD analysis confirms the formation of exfoliated structure in the HAp/PLA nanocomposites. The HAp/PLA nanocomposites exhibit better static and dynamic mechanical properties than unreinforced PLA. Furthermore, the HAp/PLA nanocomposite with an optimum HAp content of 20wt% (20HAp/PLA) demonstrates not only the best mechanical performance but also the highest thermal stability among the nanocomposite samples. Cell studies using a mouse fibroblast cell line (L929) suggest that 20HAp/PLA shows excellent biocompatibility, which makes it a promising material for biomedical applications.
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China.
authors.forename: Yizao
authors.initials: Y
authors.lastname: Wan
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China.
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Wu
authors.affiliation: School of Mechanical and Electrical Engineering, East China Jiaotong University, Nanchang 330013, China.
authors.forename: Guangyao
authors.initials: G
authors.lastname: Xiong
authors.affiliation: Hebei Provincial Key Laboratory of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, Hebei United University, Tangshan 063009, Hebei, China.
authors.forename: Guifu
authors.initials: G
authors.lastname: Zuo
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, China.
authors.forename: Kaijing
authors.initials: K
authors.lastname: Ren
authors.affiliation: School of Chemical Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China.
authors.forename: Zheren
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300072, China. Electronic address: hlluotju@126.com.
authors.forename: Honglin
authors.initials: H
authors.lastname: Luo
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D004355:Drug Stability; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D055595:Mechanical Phenomena; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D011091:Polyesters; C499699:hydroxyapatite-polylactide; D017886:Durapatite
keywords: Hydroxyapatite; Intercalation; Nanocomposites; Nanoplate; Polylactide