title: Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl- and arylthiosubstituted maleimides.
abstract: Bis-alkylthio maleimido derivatives have been prepared from teicoplanin pseudoaglycon by reaction of its primary amino group with N-ethoxycarbonyl bis-alkylthiomaleimides. Some of the new derivatives displayed excellent antibacterial activity against resistant bacteria.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Magdolna
authors.initials: M
authors.lastname: Csávás
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Adrienn
authors.initials: A
authors.lastname: Miskovics
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Szűcs
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Rőth
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Zsolt L
authors.initials: ZL
authors.lastname: Nagy
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Ilona
authors.initials: I
authors.lastname: Bereczki
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Mihály
authors.initials: M
authors.lastname: Herczeg
authors.affiliation: Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Batta
authors.affiliation: Department of Dermatology, Venerology and Dermatooncology, Microbiology Laboratory, Semmelweis University, Budapest, Hungary.
authors.forename: Éva
authors.initials: É
authors.lastname: Nemes-Nikodém
authors.affiliation: Department of Dermatology, Venerology and Dermatooncology, Microbiology Laboratory, Semmelweis University, Budapest, Hungary.
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.affiliation: Department of Dermatology, Venerology and Dermatooncology, Microbiology Laboratory, Semmelweis University, Budapest, Hungary.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rozgonyi
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Anikó
authors.initials: A
authors.lastname: Borbás
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017334:Teicoplanin / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D008301:Maleimides; D017334:Teicoplanin
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