title: Percutaneous intervention for mitral regurgitation.
abstract: Percutaneous treatment of mitral regurgitation (MR) is a promising alternative for patients with functional MR (FMR) who are not appropriate for surgery and are not responding to optimal medical therapy and cardiac resynchronization therapy. Unlike degenerative MR, where repair therapy is clearly preferred, the optimal approach for FMR has not been defined. Challenges for novel mitral repair devices are to demonstrate safety and superior efficacy to medical management in higher risk patients. Transcatheter mitral valve replacement is emerging as a feasible therapy, but requires significant additional clinical trials to define its place in treating heart failure related to MR.
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Sarraf
authors.affiliation: NorthShore University HealthSystem, Evanston, IL, USA. Electronic address: tfeldman@tfeldman.org.
authors.forename: Ted
authors.initials: T
authors.lastname: Feldman
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods*; D058406:Cardiac Resynchronization Therapy / Q000379:methods; D002317:Cardiovascular Agents / Q000494:pharmacology; D006333:Heart Failure / Q000150:complications / Q000503:physiopathology; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008943:Mitral Valve / Q000503:physiopathology / Q000601:surgery; D058386:Mitral Valve Annuloplasty / Q000379:methods; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000628:therapy; D018579:Patient Selection; D020379:Risk Adjustment
chemical_list: D002317:Cardiovascular Agents
keywords: Heart failure; Mitral regurgitation; Mitral valve; Valve replacement