title: Activity of clarithromycin or rifampin alone or in combination against experimental Rhodococcus equi infection in mice.
abstract: Treatment of mice with the combination of clarithromycin with rifampin resulted in a significantly lower number of Rhodococcus equi CFU in the organs of mice than treatment with either drug alone or placebo. There was no significant difference in the number of R. equi CFU between mice treated with clarithromycin monotherapy, rifampin monotherapy, or placebo. The combination of clarithromycin with rifampin conferred a clear advantage over either drug as monotherapy in this model of chronic R. equi infection.
authors.affiliation: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
authors.forename: Alexandra J
authors.initials: AJ
authors.lastname: Burton
authors.affiliation: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA gigueres@uga.edu.
authors.forename: Steeve
authors.initials: S
authors.lastname: Giguère
authors.affiliation: Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
authors.forename: Londa J
authors.initials: LJ
authors.lastname: Berghaus
authors.affiliation: Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Hondalus
mesh_terms: D000193:Actinomycetales Infections / Q000188:drug therapy*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017291:Clarithromycin / Q000627:therapeutic use*; D004338:Drug Combinations; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D016929:Rhodococcus equi / Q000187:drug effects* / Q000472:pathogenicity*; D012293:Rifampin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D017291:Clarithromycin; D012293:Rifampin
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