title: [Evaluation of prognostic factors for the development of cholelithiasis in patients with metabolic syndrome].
abstract: The aim of study to determine the leading clinical and immunological parameters, reflecting the high risk of development and progression of gallstone disease in patients with metabolic syndrome.
  
  
  METHODS
  An assessment of clinical, biochemical and immunological parameters in 54 patients with gallstone disease associated with the metabolic syndrome and in comparison groups (31 with metabolic syndrome without gallstone disease and 29 with gallstone disease only) were made. For modeling the significant correlation and prediction of the effect of different combinations of factors on the risk of gallstone disease formation in patients with metabolic syndrome was used the multiple logistic regression analysis.
  
  
  RESULTS
  In accordance with our results the main risk factors of gallstone formation in patients with metabolic syndrome are the age (P = 0.02), waist volume (P = 0.0002), the increase of serum concentration of GGTP (P = 0.00001), MMP-9 (P = 0.002) and TIMP-1 (P = 0.02).
  
  
  CONCLUSIONS
  The results of our study have shown that in patients with metabolic syndrome was estimated the high risk of gallstone disease formation compared and the most significant factors of it formation are the patients age, waist volume and increase of serum concentration of GGTP, MMP-9 and TIMP-1.
authors.forename: O V
authors.initials: OV
authors.lastname: Gaus
authors.forename: V A
authors.initials: VA
authors.lastname: Akhmedov
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002769:Cholelithiasis / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D008875:Middle Aged; D011379:Prognosis; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism*; D055105:Waist Circumference; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
chemical_list: C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; D005723:gamma-Glutamyltransferase; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9