title: Antioxidant strategies in the management of diabetic neuropathy.
abstract: Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complication and can be devastating because it can lead to disability. There is an increasing body of evidence associating diabetic neuropathy with oxidative stress. Oxidative stress results from the production of oxygen free radicals in the body in excess of its ability to eliminate them by antioxidant activity. Antioxidants have different mechanisms and sites of actions by which they exert their biochemical effects and ameliorate nerve dysfunction in diabetes by acting directly against oxidative damage. This review will examine different strategies for managing diabetic neuropathy which rely on exogenous antioxidants.
authors.affiliation: Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, University Road, Durban 4000, South Africa.
authors.forename: Ayodeji Babatunde
authors.initials: AB
authors.lastname: Oyenihi
authors.affiliation: Department of Biochemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2002, South Africa.
authors.forename: Ademola Olabode
authors.initials: AO
authors.lastname: Ayeleso
authors.affiliation: Department of Biochemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2002, South Africa.
authors.forename: Emmanuel
authors.identifier: 0000-0003-3509-6770
authors.initials: E
authors.lastname: Mukwevho
authors.affiliation: Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, University Road, Durban 4000, South Africa.
authors.forename: Bubuya
authors.initials: B
authors.lastname: Masola
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D016207:Cytokines / Q000276:immunology*; D003929:Diabetic Neuropathies / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000276:immunology*; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology
chemical_list: D000975:Antioxidants; D016207:Cytokines; D017382:Reactive Oxygen Species
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