title: Protein modification and maintenance systems as biomarkers of ageing.
abstract: Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing. Within the frame of the Mark-Age project, the workpackage dedicated to "markers based on proteins and their modifications" has been firstly focused on enzymatic and non-enzymatic post-translational modifications of serum proteins by carbohydrates. The second focus of the workpackage has been directed towards protein maintenance systems that are involved either in protein quality control (ApoJ/Clusterin) or in the removal of oxidatively damaged proteins through degradation and repair (proteasome and methionine sulfoxide reductase systems). This review describes the most relevant features of these protein modifications and maintenance systems, their fate during ageing and/or their implication in ageing and longevity.
authors.affiliation: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium; Department of Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.
authors.forename: Valerie
authors.initials: V
authors.lastname: Vanhooren
authors.affiliation: Department of Cardiothoracic Surgery of the Martin Luther University Halle-Wittenberg, Ernst Grube Str. 40, 06120 Halle/Saale, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Navarrete Santos
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Voutetakis
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, UMR 8256, Biological adaptation and ageing - IBPS, F-75005 Paris, France; CNRS-UMR 8256, F-75005 Paris, France; INSERM U1164, F-75005 Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Petropoulos
authors.affiliation: VIB Inflammation Research Center, Technologiepark 927, B-9052 Ghent, Belgium; Department of Molecular Biology, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium.
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
authors.affiliation: Department of Cardiothoracic Surgery of the Martin Luther University Halle-Wittenberg, Ernst Grube Str. 40, 06120 Halle/Saale, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Simm
authors.affiliation: National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry and Biotechnology, 48 Vas. Constantinou Ave., Athens 11635, Greece.
authors.forename: Efstathios S
authors.initials: ES
authors.lastname: Gonos
authors.affiliation: Sorbonne Universités, UPMC University Paris 06, UMR 8256, Biological adaptation and ageing - IBPS, F-75005 Paris, France; CNRS-UMR 8256, F-75005 Paris, France; INSERM U1164, F-75005 Paris, France. Electronic address: bertrand.friguet@upmc.fr.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Friguet
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D008136:Longevity / Q000502:physiology*; D010084:Oxidation-Reduction; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D059748:Proteolysis
chemical_list: D015415:Biomarkers
keywords: Ageing; Biomarkers; Protein maintenance; Protein modification