title: Comparison of Subdural Hematoma Risk between Hemodialysis and Peritoneal Dialysis Patients with ESRD.
abstract: OBJECTIVE
  This study compared the risk of subdural hematoma (SDH) and subsequent mortality in hemodialysis (HD) and peritoneal dialysis (PD) patients with ESRD.
  
  
  METHODS
  Claims data were obtained from the National Health Insurance Administration Research Database in Taiwan. This retrospective cohort study comprised 10,136 PD patients and 10,136 HD patients with newly diagnosed ESRD from 1998 to 2010. Patients were matched by propensity score and year of dialysis initiation. Incidence rates and hazard ratios of SDH as well as odds ratios of subsequent 30-day deaths from SDH were evaluated from the date of the first dialysis session to the date when SDH was diagnosed, or the date of renal transplantation, death, withdraw from insurance, or the end of the follow-up period (December 31, 2011).
  
  
  RESULTS
  Median (25th percentile, 75th percentile) follow-up times for SDH events were 3.61 years (1.91, 6.33) and 3.33 years (1.83, 5.66) in the HD and PD cohorts, respectively. The overall SDH incidence rate (95% confidence interval [95% CI]) was 61.4% higher in the HD cohort than in the PD cohort (34.7 [95% CI, 31.4 to 35.4] versus 21.5 [95% CI, 20.2 to 22.9] per 10,000 person-years, with an adjusted hazard ratio of 1.62 [95% CI, 1.17 to 2.33]). Approximately 152 of 253 (60%) of SDH events were associated with trauma. Subsequent 30-day SDH-related mortality was not statistically higher in HD patients than in PD patients (29.1% versus 25.3%; adjusted odds ratio, 1.30; 95% CI, 0.70 to 2.41).
  
  
  CONCLUSIONS
  HD patients have a higher risk of developing SDH than PD patients. Both patient groups have a high risk of mortality. Routine education on fall prevention is needed for dialysis patients.
authors.affiliation: Department of Internal Medicine and Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan; Divisions of Nephrology and.
authors.forename: I-Kuan
authors.initials: IK
authors.lastname: Wang
authors.affiliation: Neurosurgery.
authors.forename: Yu-Kai
authors.initials: YK
authors.lastname: Cheng
authors.affiliation: Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Lin
authors.affiliation: Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan;
authors.forename: Chiao-Ling
authors.initials: CL
authors.lastname: Peng
authors.affiliation: Divisions of Nephrology and.
authors.forename: Che-Yi
authors.initials: CY
authors.lastname: Chou
authors.affiliation: Divisions of Nephrology and.
authors.forename: Chiz-Tzung
authors.initials: CT
authors.lastname: Chang
authors.affiliation: Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan; and Chang Gung University College of Medicine, Taoyuan, Taiwan.
authors.forename: Tzung-Hai
authors.initials: TH
authors.lastname: Yen
authors.affiliation: Divisions of Nephrology and.
authors.forename: Chiu-Ching
authors.initials: CC
authors.lastname: Huang
authors.affiliation: Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan; Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; fcsung1008@yahoo.com.
authors.forename: Fung-Chang
authors.initials: FC
authors.lastname: Sung
authors.affiliation: Graduate Institute of Clinical Medical Science, China Medical University College of Medicine, Taichung, Taiwan; Department of Neurology, and.
authors.forename: Chung Y
authors.initials: CY
authors.lastname: Hsu
mesh_terms: D000368:Aged; D016208:Databases, Factual; D005260:Female; D006408:Hematoma, Subdural / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000401:mortality; D057216:Propensity Score; D016016:Proportional Hazards Models; D006435:Renal Dialysis / Q000009:adverse effects* / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
keywords: ESRD; hemodialysis; mortality; peritoneal dialysis; subdural hematoma
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