title: Effectiveness of bronchoscopic lung volume reduction using unilateral endobronchial valve: a systematic review and meta-analysis.
abstract: BACKGROUND
  Bronchoscopic lung volume reduction (BLVR) can be suggested as an alternative for surgical lung volume reduction surgery for severe emphysema patients. This article intends to evaluate by systematic review the safety and effectiveness of BLVR using a one-way endobronchial valve.
  
  
  METHODS
  A systematic search of electronic databases, including MEDLINE, EMBASE, and the Cochrane Library, as well as eight domestic databases up to December 2013, was performed. Two reviewers independently screened all references according to selection criteria. The Scottish Intercollegiate Guidelines Network criterion was used to assess quality of literature. Data from randomized controlled trials were combined and meta-analysis was performed.
  
  
  RESULTS
  This review included 15 studies. Forced expiratory volume in 1 second (FEV1) improved in the intervention group compared with the control group (mean difference [MD]=6.71, 95% confidence interval [CI]: 3.31-10.11). Six-minute walking distance (MD=15.66, 95% CI: 1.69-29.64) and cycle workload (MD=4.43, 95% CI: 1.80-7.07) also improved. In addition, St George's Respiratory Questionnaire score decreased (MD=4.29, 95% CI: -6.87 to -1.71) in the intervention group. In a subgroup analysis of patients with complete fissure, the FEV1 change from baseline was higher in the BLVR group than in the control group for both 6 months (MD=15.28, P<0.001) and 12 months (MD=17.65, P<0.001), whereas for patients with incomplete fissure, FEV1 and 6-minute walking distance showed no change. One-year follow-up randomized controlled trials reported deaths, although the cause of death was not related to BLVR. Respiratory failure and pneumothorax incidence rates were relatively higher in the BLVR group, but the difference was not significant.
  
  
  CONCLUSIONS
  BLVR may be an effective and safe procedure for the treatment of severe COPD patients with emphysema, based on existing studies.
authors.affiliation: National Evidence-Based Healthcare Collaborating Agency, Seoul, Republic of Korea.
authors.forename: Miyoung
authors.initials: M
authors.lastname: Choi
authors.affiliation: National Evidence-Based Healthcare Collaborating Agency, Seoul, Republic of Korea.
authors.forename: Worl Suk
authors.initials: WS
authors.lastname: Lee
authors.affiliation: National Evidence-Based Healthcare Collaborating Agency, Seoul, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Lee
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kyeongman
authors.initials: K
authors.lastname: Jeon
authors.affiliation: Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Seungsoo
authors.initials: S
authors.lastname: Sheen
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sanghoon
authors.initials: S
authors.lastname: Jheon
authors.affiliation: Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Young Sam
authors.initials: YS
authors.lastname: Kim
mesh_terms: D001999:Bronchoscopy / Q000009:adverse effects / Q000295:instrumentation*; D016009:Chi-Square Distribution; D017079:Exercise Tolerance; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology / Q000601:surgery*; D011013:Pneumonectomy / Q000009:adverse effects / Q000295:instrumentation*; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D020127:Recovery of Function; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: bronchoscopic valve lung volume reduction; endobronchial valve; meta-analysis; systematic review
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