title: [The role of genetic polymorphisms of interleukins in chronic lymphocytic leukemia in patients of different ages].
abstract: Chronic lymphocytic leukemia (CLL) is a multifactorial disease, in which development the important role played the cytokine genes, in particular interleukins. This type of leukemia is more common in the elderly. The purpose of the study was to evaluate the association of genetic polymorphisms of interleukin with the development of chronic lymphocytic leukemia among residents of the Central Chernozem region of Russia. Genotyping of the -889C/T IL-1A, -590C/T IL-4 and VNTR IL-1 Ra was conducted in 206 patients with CLL and 307 individuals of the control group. The study found that the genetic risk factor for the development of CLL is allele -590T IL-4 (OR=-1,45). The development of thrombocytopenia in patients with CLL is associated with genetic variants -889T IL-1A (OR=1,95), -889TT IL-1A (OR=6,2) and IL-1Ra*1 (OR=-2,32).
authors.forename: S S
authors.initials: SS
authors.lastname: Sirotina
authors.forename: T S
authors.initials: TS
authors.lastname: Tikunova
authors.forename: K I
authors.initials: KI
authors.lastname: Proshchaev
authors.forename: O A
authors.initials: OA
authors.lastname: Efremova
authors.forename: I V
authors.initials: IV
authors.lastname: Batlutskaia
authors.forename: T I
authors.initials: TI
authors.lastname: Iakunchenko
authors.forename: F I
authors.initials: FI
authors.lastname: Sobianin
authors.forename: M I
authors.initials: MI
authors.lastname: Churnosov
authors.forename: S M
authors.initials: SM
authors.lastname: Alekseev
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics*; D015847:Interleukin-4 / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013921:Thrombocytopenia / Q000209:etiology / Q000235:genetics*; D055815:Young Adult
chemical_list: C508598:IL4 protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053582:Interleukin-1alpha; D015847:Interleukin-4