title: A proposed role for selective autophagy in regulating auxin-dependent lateral root development under phosphate starvation in Arabidopsis.
abstract: Plants respond to limited soil nutrient availability by inducing more lateral roots (LR) to increase the root surface area. At the cellular level, nutrient starvation triggers the process of autophagy through which bulk degradation of cellular materials is achieved to facilitate nutrient mobilization. Whether there is any link between the cellular autophagy and induction of LR had remained unknown. We recently showed that the S-Domain receptor Kinase (ARK2) and U Box/Armadillo Repeat-Containing E3 ligase (PUB9) module is required for lateral root formation under phosphate starvation in Arabidopsis thaliana.(1) We also showed that PUB9 localized to autophagic bodies following either activation by ARK2 or under phosphate starvation and ark2-1/pub9-1 plants displayed lateral root defects with inability to accumulate auxin in the root tips under phosphate starvation.(1) Supplementing exogenous auxin was sufficient to rescue the LR defects in ark2-1/pub9-1 mutant. Blocking of autophagic responses in wild-type Arabidopsis also resulted in inhibition of both lateral roots and auxin accumulation in the root tips indicating the importance of autophagy in mediating auxin accumulation under phosphate starved conditions.(1) Here, we propose a model for ARK2/AtPUB9 module in regulation of lateral root development via selective autophagy.
authors.affiliation: a Department of Biological Sciences; University of Calgary ; Calgary , Canada.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Sankaranarayanan
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Samuel
mesh_terms: D000222:Adaptation, Physiological; D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D001343:Autophagy; D018506:Gene Expression Regulation, Plant; D007210:Indoleacetic Acids / Q000378:metabolism*; D018519:Meristem / Q000254:growth & development / Q000378:metabolism; D010710:Phosphates / Q000172:deficiency* / Q000378:metabolism; D059828:Plant Cells / Q000502:physiology; D018517:Plant Roots / Q000254:growth & development* / Q000378:metabolism; D015398:Signal Transduction; D012987:Soil / Q000737:chemistry; D013312:Stress, Physiological; D014157:Transcription Factors / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D007210:Indoleacetic Acids; D010710:Phosphates; D012987:Soil; D014157:Transcription Factors; D044767:Ubiquitin-Protein Ligases
keywords: Pi starvation; U-box protein; aateral roots; arabidopsis; autophagy; auxin; receptor kinase
references.citation: Curr Opin Plant Biol. 2007 Dec;10(6):587-93
references.pmid: 17702643
references.citation: Plant Cell. 2008 Dec;20(12):3258-72
references.pmid: 19106375
references.citation: PLoS Genet. 2013;9(1):e1003196
references.pmid: 23341779
references.citation: Nature. 2001 Nov 15;414(6861):271-6
references.pmid: 11713520
references.citation: Nat Rev Genet. 2007 Jun;8(6):437-49
references.pmid: 17510664
references.citation: Curr Opin Plant Biol. 1998 Oct;1(5):434-9
references.pmid: 10066623
references.citation: Genes Dev. 2006 Oct 15;20(20):2902-11
references.pmid: 17043314
references.citation: Mol Cell. 2009 Feb 27;33(4):505-16
references.pmid: 19250911
references.citation: Nature. 2007 Apr 5;446(7136):640-5
references.pmid: 17410169
references.citation: Trends Plant Sci. 2013 Aug;18(8):450-8
references.pmid: 23701908
references.citation: Curr Opin Plant Biol. 2007 Oct;10(5):453-60
references.pmid: 17900969
references.citation: Plant Physiol. 2004 Jan;134(1):59-66
references.pmid: 14657406
references.citation: Sci STKE. 2001 Dec 18;2001(113):re22
references.pmid: 11752632
references.citation: Plant Physiol. 2008 Aug;147(4):2084-95
references.pmid: 18552232
references.citation: Plant Cell Physiol. 2012 Aug;53(8):1355-65
references.pmid: 22764279
references.citation: Plant Physiol. 2014 Jun 25;165(4):1647-1656
references.pmid: 24965176
references.citation: Nat Chem Biol. 2012 Apr 01;8(5):477-85
references.pmid: 22466420
references.citation: Plant Physiol. 2005 Feb;137(2):681-91
references.pmid: 15681664
references.citation: Plant Physiol. 2003 Jun;132(2):530-43
references.pmid: 12805585
references.citation: Plant Cell. 2001 Apr;13(4):843-52
references.pmid: 11283340
references.citation: Plant Cell. 2006 Mar;18(3):699-714
references.pmid: 16489122
references.citation: Development. 2005 Oct;132(20):4521-31
references.pmid: 16192309
references.citation: Plant Cell. 2000 Jul;12(7):1093-101
references.pmid: 10899976
references.citation: Trends Plant Sci. 2004 Jun;9(6):302-8
references.pmid: 15165562
references.citation: Plant Cell. 2002 Oct;14 (10 ):2339-51
references.pmid: 12368490
references.citation: Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8790-4
references.pmid: 18559858
references.citation: Mol Cell. 2009 Feb 27;33(4):517-27
references.pmid: 19250912
references.citation: Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10763-8
references.pmid: 11526204
references.citation: Plant Physiol. 2001 Jun;126(2):875-82
references.pmid: 11402214
references.citation: Plant Cell. 2001 Mar;13(3):465-80
references.pmid: 11251090
references.citation: Nature. 2007 Apr 5;446(7136):621-2
references.pmid: 17410164
references.citation: Nat Cell Biol. 2010 Sep;12 (9):836-41
references.pmid: 20811356
references.citation: Trends Plant Sci. 2001 Sep;6(9):420-5
references.pmid: 11544131