title: [Genetical aspects of surgical treatment in patients with hereditary breast cancer].
abstract: Numerous available results of investigations confirmed the important role of prophylactic bilateral laparoscopic salpingo-oophorectomy and contralateral prophylactic subcutaneous mastectomy in decrease of risks of malignant tumors of the reproductive system when mutation carriers of BRCA1 and BRCA2 presented. Recommendations to surgical treatment of hereditary breast cancer are considered as a very difficult task which should be based on risks and advantages of prophylactic surgical interventions. Presented surgical operations could be applied in mutation carriers of reparation DNA genes and patients with hereditary breast cancer aimed to improve the indices of general survival rate and quality of life.
authors.forename: E M
authors.initials: EM
authors.lastname: Bit-Sava
mesh_terms: D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006301:Health Services Needs and Demand; D061325:Hereditary Breast and Ovarian Cancer Syndrome / Q000235:genetics / Q000473:pathology / Q000523:psychology / Q000601:surgery; D006801:Humans; D016462:Mammaplasty / Q000379:methods*; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics / Q000517:prevention & control; D009367:Neoplasm Staging; D010052:Ovariectomy / Q000379:methods*; D011314:Preventive Health Services; D011788:Quality of Life; D018570:Risk Assessment; D012426:Russia; D058994:Salpingectomy / Q000379:methods*; D016019:Survival Analysis