title: Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis.
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) may be characterized by periods of remissions and chronic or acute relapses. The complexity of clinical presentation of the SLE patients leads to incorrect evaluation of disease activity. Mean platelet volume (MPV) has been studied as a simple inflammatory marker in several diseases. There is no study in the literature about MPV levels in adult SLE patients with arthritis.
  
  
  OBJECTIVE
  We aimed to investigate the MPV levels in the SLE population with arthritis during and between activations.
  
  
  METHODS
  The study consisted of 44 SLE patients with arthritis in activation period (Group 1), the same 44 SLE patients with arthritis in remission period (Group 2) and 44 healthy controls (Group 3). Erythrocyte sedimentation rate (ESR), creactive protein (CRP), white blood cell count, platelet count, and mean platelet volume (MPV) levels were retrospectively recorded from patient files.
  
  
  RESULTS
  The mean ages of the SLE subjects were 42 ± 16 years, while the mean ages of controls was 41 ± 17 years. MPV was significantly lower in Group 1(7.66±0.89fL) than in Group 2 (8.61±1.06 fL) and Group 3(8.62±1.11fL) (p<0.0001). The differences between groups reached statistical significance.
  
  
  CONCLUSIONS
  We suggest that MPV levels decrease in patients with arthritis of SLE activation when compared to the same patients in remission and healthy controls.
authors.affiliation: Gaziosmanpasa University, Faculty of Medicine, Department of Internal Medicine, Tokat, Turkey.
authors.forename: Sahin
authors.initials: S
authors.lastname: Safak
authors.affiliation: Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Sivas, Turkey.
authors.forename: Ali Ugur
authors.initials: AU
authors.lastname: Uslu
authors.affiliation: Cumhuriyet University, Faculty of Medicine, Department of Internal Medicine, Sivas, Turkey.
authors.forename: Korkmaz
authors.initials: K
authors.lastname: Serdal
authors.affiliation: Gaziosmanpasa University, Faculty of Medicine, Department of Internal Medicine, Tokat, Turkey.
authors.forename: Tasliyurt
authors.initials: T
authors.lastname: Turker
authors.affiliation: Erciyes University, Faculty of Medicine, Department of Rheumatology, Kayseri, Turkey.
authors.forename: Senel
authors.initials: S
authors.lastname: Soner
authors.affiliation: Bozok University, Faculty of Medicine, Department of Internal Medicine, Yozgat, Turkey.
authors.forename: Akyol
authors.initials: A
authors.lastname: Lutfi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000097:blood* / Q000150:complications / Q000473:pathology; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000473:pathology; D007958:Leukocyte Count; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Arthritis; Mean platelet volume; Systemic lupus erythematosus
references.citation: Curr Opin Rheumatol. 2000 Sep;12(5):364-8
references.pmid: 10990170
references.citation: Platelets. 2009 Jun;20(4):277-81
references.pmid: 19459134
references.citation: Clin Rheumatol. 2009 Aug;28(8):975-8
references.pmid: 19283330
references.citation: Hematology. 2007 Aug;12(4):353-7
references.pmid: 17654065
references.citation: Stroke. 2004 Mar;35(3):622-6
references.pmid: 14976328
references.citation: Platelets. 2013;24(4):320-3
references.pmid: 22720903
references.citation: Ann Rheum Dis. 1991 Aug;50(8):583-7
references.pmid: 1888203
references.citation: Rheumatol Int. 2010 Jun;30(8):1125-9
references.pmid: 20066426
references.citation: Joint Bone Spine. 2008 May;75(3):291-4
references.pmid: 18403245
references.citation: Autoimmunity. 2001;33(2):85-94
references.pmid: 11264787
references.citation: Clin Lab Med. 1993 Dec;13(4):937-50
references.pmid: 8313690
references.citation: Blood. 2010 Sep 16;116(11):1951-7
references.pmid: 20538795
references.citation: Platelets. 2011;22(8):602-10
references.pmid: 21679034
references.citation: Platelets. 1994;5(3):149-55
references.pmid: 21043629
references.citation: Am J Gastroenterol. 2001 Mar;96(3):776-81
references.pmid: 11280550
references.citation: Br J Haematol. 2002 May;117(2):399-404
references.pmid: 11972524
references.citation: Arthritis Rheum. 1989 Sep;32(9):1107-18
references.pmid: 2775320
references.citation: Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii61-4
references.pmid: 17934099
references.citation: J Rheumatol. 2005 Nov;32(11):2150-5
references.pmid: 16265693
references.citation: Curr Pharm Des. 2011;17(1):47-58
references.pmid: 21247392
references.citation: Acta Reumatol Port. 2007 Oct-Dec;32(4):317-22
references.pmid: 18159197
references.citation: Blood Rev. 1993 Jun;7(2):104-13
references.pmid: 8369659
references.citation: Ann Rheum Dis. 1994 Oct;53(10):675-80
references.pmid: 7979581
references.citation: Arthritis Rheum. 2008 Dec 15;59(12):1814-20
references.pmid: 19035410