title: Systematic review of neurocognition in people with co-occurring alcohol misuse and depression.
abstract: BACKGROUND
  Alcohol misuse and depression represent two major social and health problems globally. These conditions commonly co-occur and both are associated with significant cognitive impairment. Despite this, few studies have examined the impact on cognitive functioning of co-occurring alcohol misuse and depression. This study aims to critically review findings from peer-reviewed published articles examining neuropsychological test performance among samples of people with co-occurring alcohol misuse and depression.
  
  
  METHODS
  A comprehensive literature search was conducted, yielding six studies reporting neuropsychological profiles of people with co-occurring alcohol misuse and depression. Results comparing cognitive functioning of people with this comorbidity to those with alcohol misuse alone, depression alone, healthy controls and published norms were examined as well as those describing the correlation between depressive symptoms and cognitive functioning in people with alcohol use disorders.
  
  
  RESULTS
  In the majority of instances, the comorbid groups did not differ significantly from those with depression only or alcohol misuse only, nor from healthy controls or published norms. In the cases where a difference in neuropsychological test scores between groups was found, it was not consistently identified across studies. However, visual memory was identified in two studies as being impaired in comorbid samples and is worthy of inclusion in future studies.
  
  
  CONCLUSIONS
  Due to the small number of included studies and the large variation in inclusion criteria as well as differing assessment tools and methodologies between studies, the review did not include a quantitative synthesis.
  
  
  CONCLUSIONS
  Research into cognitive deficits among people with singly occurring versus co-occurring alcohol misuse and depression is accumulating. Evidence suggests that the neuropsychological performance among samples with this comorbidity is generally not severely impaired and is unlikely to preclude benefit from treatment.
authors.affiliation: Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia; NHMRC Centre of Research Excellence in Mental Health and Substance Use, Australia. Electronic address: sally.hunt@newcastle.edu.au.
authors.forename: Sally A
authors.initials: SA
authors.lastname: Hunt
authors.affiliation: Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia; NHMRC Centre of Research Excellence in Mental Health and Substance Use, Australia; National Drug and Alcohol Research Centre, University of New South Wales, Australia. Electronic address: f.kaylambkin@unsw.edu.au.
authors.forename: Frances J
authors.initials: FJ
authors.lastname: Kay-Lambkin
authors.affiliation: Centre for Translational Neuroscience and Mental Health, University of Newcastle, Australia; NHMRC Centre of Research Excellence in Mental Health and Substance Use, Australia. Electronic address: amanda.baker@newcastle.edu.au.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Baker
authors.affiliation: School of Psychology, University of Newcastle, Australia. Electronic address: pat.michie@newcastle.edu.au.
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Michie
mesh_terms: D019973:Alcohol-Related Disorders / Q000453:epidemiology* / Q000523:psychology*; D003072:Cognition Disorders / Q000453:epidemiology* / Q000523:psychology*; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology* / Q000523:psychology*; D006801:Humans; D009483:Neuropsychological Tests
keywords: Alcohol; Cognitive function; Comorbidity; Depression; Neurocognition; Systematic review