title: Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.
abstract: Anti-citrullinated peptide antibody (ACPA) is a highly specific autoantibody to rheumatoid arthritis (RA). Recent studies have revealed that periodontal disease (PD) is closely associated with RA and production of ACPA in RA. Analyses of associations between PD and ACPA production in a healthy population may deepen our understandings. Here, we analyzed a total of 9554 adult healthy subjects. ACPA and IgM-rheumatoid factor (RF) was quantified and PD status was evaluated using the number of missing teeth (MT), the Community Periodontal Index (CPI) and Loss of Attachment (LA) for these subjects. PD status was analyzed for its association with the positivity and categorical levels of ACPA and RF conditioned for covariates which were shown to be associated with PD, ACPA or RF. As a result, all of MT, CPI and LA showed suggestive or significant associations with positivity (p = 0.024, 0.0042 and 0.037, respectively) and levels of ACPA (p ≤ 0.00031), but none of the PD parameters were associated with those of RF. These association patterns were also observed when we analyzed 6206 non-smokers of the participants. The significant associations between PD parameters and positivity and levels of ACPA in healthy population support the fundamental involvement of PD with ACPA production.
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan; Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan. Electronic address: a0001101@kuhp.kyoto-u.ac.jp.
authors.forename: Chikashi
authors.initials: C
authors.lastname: Terao
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Asai
authors.affiliation: Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Motomu
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yamazaki
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ohmura
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamaguchi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Katsu
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: The Lion Foundation for Dental Health, Tokyo 130-0004, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Takei
authors.affiliation: The Lion Foundation for Dental Health, Tokyo 130-0004, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kawaguchi
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Tabara
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Meiko
authors.initials: M
authors.lastname: Takahashi
authors.affiliation: Department of Health Informatics, Kyoto University School of Public Health, Kyoto 606-8501, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Nakayama
authors.affiliation: Department of Medical Ethics and Medical Genetics, Kyoto University School of Public Health, Kyoto 606-8501, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kosugi
authors.affiliation: EBM Research Center, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sekine
authors.affiliation: Department of the Control for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Fujii
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
authors.affiliation: Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Bessho
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D002956:Citrulline / Q000737:chemistry; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007564:Japan; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D010510:Periodontal Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D044382:Population Groups; D011446:Prospective Studies; D012217:Rheumatoid Factor / Q000097:blood; D012306:Risk; D012907:Smoking
chemical_list: D001323:Autoantibodies; D007075:Immunoglobulin M; D010455:Peptides; D002956:Citrulline; D012217:Rheumatoid Factor
keywords: ACPA; Association study; Epidemiological study; Periodontal disease; RF; Rheumatoid arthritis