title: Use of ferric sulfate to control hepatic bleeding.
abstract: BACKGROUND
  Controlling parenchymal hemorrhage, especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face. Therefore, search for an effective method to control hepatic bleeding is an important research priority.
  
  
  OBJECTIVE
  This study attempted to determine the haemostatic effect of ferric sulfate and compare it with the standard method (suturing technique).
  
  
  METHODS
  In this animal model study, 60 male Wistar rats were used. An incision (2 cm in length and 1/2 cm in depth) was made on each rat's liver and the hemostasis time was measured using ferric sulfate with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using simple suturing. The liver tissue was assessed for pathological changes.
  
  
  RESULTS
  In all the groups, complete hemostasis occurred. Hemostasis times of different concentrations of ferric sulfate were significantly less than those of the control group (P < 0.001).
  
  
  CONCLUSIONS
  Ferric sulfate was effective in controlling hepatic bleeding in rats.
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Nouri
authors.affiliation: Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sharif
keywords: Ferric Sulfate; Hemostasis; Liver; Rats
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