title: Rapid in vivo multicomponent T2 mapping of human knee menisci.
abstract: OBJECTIVE
  To compare multicomponent T2 parameters of menisci measured using Multicomponent Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) in asymptomatic volunteers and osteoarthritis (OA) patients with intact and torn menisci.
  
  
  METHODS
  The prospective study was performed with Institutional Review Board approval and with all subjects signing written informed consent. mcDESPOT was performed on the knee joint of 12 asymptomatic volunteers and 14 patients with knee OA. Single-component T2 relaxation time (T2Single ), T2 relaxation time of the fast relaxing water component (T2F ), and the slow relaxing water component (T2S ), and fraction of the fast relaxing water component (FF ) of the medial and lateral menisci were measured. Multivariate linear regression models were used to compare mcDESPOT parameters between normal menisci in asymptomatic volunteers, intact menisci in OA patients, and torn menisci in OA patients with adjustment for differences in age between subjects.
  
  
  RESULTS
  The mean mcDESPOT parameters for normal menisci in asymptomatic volunteers, intact menisci in OA patients, and torn menisci in OA patients were respectively 16.1 msec, 18.8 msec, and 22.7 msec for T2Single ; 9.0 msec, 10.0 msec, and 11.1 msec for T2F ; 24.4 msec, 27.7 msec, and 31.4 msec for T2S ; and 34%, 32%, 27% for FF . There were significant differences (P < 0.05) in T2Single , T2F , T2S , and FF between the three groups of menisci.
  
  
  CONCLUSIONS
  The menisci of OA patients had significantly higher T2Single , T2F , and T2S and significantly lower FF than normal menisci in asymptomatic volunteers with greater changes in multicomponent T2 parameters noted in torn than intact menisci in OA patients.
authors.affiliation: Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.|Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Alexey
authors.initials: A
authors.lastname: Samsonov
authors.affiliation: Department of Orthopedics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Wilson
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blankenbaker
authors.affiliation: Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Walter F
authors.initials: WF
authors.lastname: Block
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kijowski
mesh_terms: D000328:Adult; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D007718:Knee Injuries / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000473:pathology*; D011446:Prospective Studies; D015203:Reproducibility of Results
keywords: T2; cartilage; knee; meniscus; quantitative magnetic resonance imaging
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