title: Laparoscopic pancreaticoduodenectomy should not be routine for resection of periampullary tumors.
abstract: BACKGROUND
  Laparoscopic pancreaticoduodenectomy (LPD) is a difficult procedure that has become increasingly popular. Nevertheless, comparative data on outcomes remain limited. Our aim was to compare the outcomes of LPD and open pancreaticoduodenectomy (OPD).
  
  
  METHODS
  Between April 2011 and April 2014, 46 LPD were performed and compared with 46 OPD, which theoretically can be done by the laparoscopic approach. Patients were also matched for demographic data, associated comorbidities, and underlying disease. Patient demographics and perioperative and postoperative outcomes were studied from our single center prospective database.
  
  
  RESULTS
  Lower BMI (23 vs 27 kg/m(2), p < 0.001) and a soft pancreas (57% vs 47%, p = 0.38) were observed in patients with LPD, but there were no differences in associated comorbidities or underlying disease. Surgery lasted longer in the LPD group (342 vs 264 minutes, p < 0.001). One death occurred in the LPD group (2.1% vs 0%, p = 0.28) and severe morbidity was higher (28% vs 20%, p = 0.32) in LPD due to grade C pancreatic fistula (PF) (24% vs 6%, p = 0.007), bleeding (24% vs 7%, p = 0.02), and revision surgery (24% vs 11%, p = 0.09). Pathologic examination for malignant diseases did not identify any differences between the LPD and OPD as far as size (2.51 vs 2.82 cm, p = 0.27), number of harvested (20 vs 23, p = 0.62) or invaded (2.4 vs 2, p = 0.22) lymph nodes, or R0 resection (80% vs 80%; p = 1). Hospital stays were similar (25 vs 23 days, p = 0.59). There was no difference in outcomes between approaches in patients at a lower risk of PF.
  
  
  CONCLUSIONS
  This study found that LPD is associated with higher morbidity, mainly due to more severe PF. Laparoscopic pancreaticoduodenectomy should be considered only in the subgroup of patients with a low risk of PF.
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France. Electronic address: safi.dokmak@bjn.aphp.fr.
authors.forename: Safi
authors.initials: S
authors.lastname: Dokmak
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
authors.forename: Fadhel Samir
authors.initials: FS
authors.lastname: Ftériche
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Aussilhou
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
authors.forename: Yacine
authors.initials: Y
authors.lastname: Bensafta
authors.affiliation: Department of Gastroenterology, Beaujon Hospital, Clichy, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Lévy
authors.affiliation: Department of Gastroenterology, Beaujon Hospital, Clichy, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Ruszniewski
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Belghiti
authors.affiliation: Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Sauvanet
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D016896:Treatment Outcome