title: [Metabolism of nucleotides and its inter-relation with pro-oxidant and antioxidant systems in people of different age ranges].
abstract: The interrelation of purine nucleotides with antioxidant system in blood plasma and erythrocytes depending on age, as well as the contribution of the key enzymes of purine decomposition to the formation of reactive oxygen metabolites were studied. 50 conditionally healthy people aged 40-79 years were examined. Increase in all indicators of pro-oxidant system of blood plasma with age was determined. Statistically significant interrelations between the studied parameters and age of the examined persons were determined in the blood plasma. The relationship between the glutathione peroxidase and adenosine deaminase/xanthine oxidase, adenosine deaminase and xanthine oxidase was also determined. A significant increase of products of oxidative proteins modification in plasma and erythrocytes with aging was discovered. Reduction with age of key enzymes of antioxidant protection--superoxide dismutase and glutathione peroxidase in blood plasma and erythrocytes was determined. The data obtained indicate that with age there is an imbalance in the antioxidant system in blood plasma and erythrocytes contributing to the development of pathological conditions by increasing oxidative stress, which is greatly manifested while aging.
authors.forename: S A
authors.initials: SA
authors.lastname: Zuĭkov
mesh_terms: D000243:Adenosine Deaminase / Q000097:blood / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D006835:Hydrazones / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011685:Purine Nucleotides / Q000097:blood / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000097:blood / Q000378:metabolism
chemical_list: D000975:Antioxidants; D006835:Hydrazones; D011685:Purine Nucleotides; D009569:Nitric Oxide; D005979:Glutathione Peroxidase; D014969:Xanthine Oxidase; D000243:Adenosine Deaminase