title: Nanoradiopharmaceuticals for Bone Cancer Metastasis Imaging.
abstract: Drug delivery systems are under intense investigation all around the world, especially in oncology research. Indeed, in some cases, like bone metastasis, nanodrugs may represent the last and best choice for both treatment and imaging of early cancer foci. Nuclear medicine has been using MDP labelled with 99mTc as radiopharmaceuticals for many years; however, their use as nanoradiopharmaceuticals is very innovative and creates a new way to establish radiopharmacy in this new scenario offered by nanotechnology. In this study we developed and tested nano-MDP-labelled with 99mTc in rats induced with bone cancer metastasis and the results showed that it may work in patients. However, some further experiments are required in order to initiate protocols in humans.
authors.forename: Bianca Feliciano
authors.initials: BF
authors.lastname: Coelho
authors.forename: Marta
authors.initials: M
authors.lastname: de Souza Albernaz
authors.forename: Alexandre
authors.initials: A
authors.lastname: Iscaife
authors.forename: Katia Ramos
authors.initials: KR
authors.lastname: Moreira Leite
authors.forename: Mara
authors.initials: M
authors.lastname: de Souza Junqueira
authors.forename: Emerson Soares
authors.initials: ES
authors.lastname: Bernardes
authors.forename: Emerson Oliveira
authors.initials: EO
authors.lastname: da Silva
authors.affiliation: Laboratory of Nanoradiopharmaceuticals, Brazil. ralpholiveira@uezo.rj.gov.br.
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D045744:Cell Line, Tumor; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D036103:Nanotechnology / Q000379:methods*; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000378:metabolism*
chemical_list: D019275:Radiopharmaceuticals