title: Young-age prostate cancer.
abstract: Although prostate cancer is a disease of the elderly, its diagnosis is not uncommonly made in men younger than 55 years. Both ethnic, familial and genetic factors play a role in the early onset of prostate cancer, but the biology, particularly of low-grade prostate cancers detected at young age is not well understood. Autopsy studies have shown a high prevalence of Gleason score 6 prostate cancers in men under 55 years, but mortality of prostate cancer at this young age is almost negligible. Recently, a number of susceptibility genes such as BRCA2 and HOXB13 were reported, each with their own specific biological and histopathology features. In this review, we provide an update on the most recent findings in young-age prostate cancer.
authors.affiliation: Department of Laboratory Medicine, Kuwait Cancer Control Center, Kuwait, Kuwait.
authors.forename: S
authors.initials: S
authors.lastname: Hussein
authors.affiliation: Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Satturwar
authors.affiliation: Department of Pathology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Van der Kwast
mesh_terms: D000328:Adult; D017668:Age of Onset; D024682:BRCA2 Protein / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D020022:Genetic Predisposition to Disease; D040941:Heredity; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D060787:Neoplasm Grading; D010641:Phenotype; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics / Q000473:pathology; D012307:Risk Factors
chemical_list: D024682:BRCA2 Protein; C551750:BRCA2 protein, human; D014408:Biomarkers, Tumor; C484414:HOXB13 protein, human; D018398:Homeodomain Proteins
keywords: EPIDEMIOLOGY; GENETICS; UROGENITAL PATHOLOGY