title: [Wells Syndrome in children and atopy: Retrospective study of 11 cases and review of the literature].
abstract: BACKGROUND
  Well's syndrome, or eosinophilic cellulitis, is rare in childhood, with fewer than 40 pediatric cases being reported since 1979. The physiopathology is unknown.
  
  
  METHODS
  In February 2012, members of the research group of the Department of Pediatric Dermatology Society submitted their case of Wells' syndrome in children aged 0-15 years. Details of clinical, biological and histological features and of therapeutic strategies were collected by physicians using a standardized questionnaire. Pictures were reviewed by the authors.
  
  
  RESULTS
  Eleven patients were included (average age: 6 years), with a strong prevalence of atopy (63%). Two types of clinical manifestation were noted: single or multiple cellulitis associated or not with vesiculobullous lesions and fixed urticaria. Eighty-two percent of patients had pruritus and 73% had eosinophilia. For all patients, histological examination of skin biopsies showed an eosinophilic infiltrate extending in the dermis with associated Sweet-like neutrophilic infiltrate being seen in 2 patients. The course of the disease was protracted (mean duration: 8 months) with flare-ups. Treatment varied depending on the doctors (topical or systemic steroids, tacrolimus and dapsone).
  
  
  CONCLUSIONS
  Our study confirms some of the data in the literature concerning the clinical, histological features and course of Well's syndrome in children. The key information is the high prevalence of atopic children hitherto unreported. In a setting of insect bites, vaccination, infection or traumatism, this unusual background could explain the onset of inflammatory reaction with eosinophils. Oral or topical steroids appear to be the first-line treatment in children when necessary.
  
  
  CONCLUSIONS
  Well's syndrome in children is rare and characterized by its polymorphism. We report for the first time in a series of patients a high prevalence of atopy, which raises new perspectives in understanding these rare diseases. We propose topical steroids as first-line therapy in children with superficial lesions, with oral steroids being given for cellulitic lesions or where topical therapy fails.
authors.affiliation: Dermatologie, hôpital l'Archet 2, CHU de Nice, BP 3079, 06202 Nice cedex 3, France; Pédiatrie, hôpitaux pédiatriques, CHU-Lenval, 57, avenue de la Californie, 06200 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Brun
authors.affiliation: Dermatologie, hôpital l'Archet 2, CHU de Nice, BP 3079, 06202 Nice cedex 3, France; Pédiatrie, hôpitaux pédiatriques, CHU-Lenval, 57, avenue de la Californie, 06200 Nice, France. Electronic address: chiaverini.c@chu-nice.fr.
authors.forename: C
authors.initials: C
authors.lastname: Chiaverini
authors.affiliation: Dermatologie, hôpital Saint-Eloi, CHU de Montpellier, 34295 Montpellier cedex 5, France.
authors.forename: D
authors.initials: D
authors.lastname: Bessis
authors.affiliation: Dermatologie, hôpital Robert-Debré, AP-HP, 75935 Paris cedex 19, France.
authors.forename: E
authors.initials: E
authors.lastname: Bourrat
authors.affiliation: Dermatologie, hôpital Saint-Vincent, CHRU de Lille, 59037 Lille cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Lasek-Duriez
authors.affiliation: Dermatologie, hôpital Necker, AP-HP, 75015 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Hadj-Rabia
authors.affiliation: Dermatologie, hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Boralevi
authors.affiliation: Dermatologie, hôpital l'Archet 2, CHU de Nice, BP 3079, 06202 Nice cedex 3, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Lacour
mesh_terms: D001249:Asthma / Q000150:complications; D002481:Cellulitis / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications; D020405:Dermis / Q000378:metabolism; D004485:Eczema / Q000150:complications; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D011537:Pruritus / Q000150:complications; D012189:Retrospective Studies; D014581:Urticaria / Q000150:complications
keywords: Atopie; Atopy; Child; Corticothérapie; Enfant; Eosinophilic infiltrate; Infiltrat éosinophilique; Steroids; Syndrome de Wells; Wells’ syndrome