title: Robust and sustained effect of ketamine infusions coadministered with conventional antidepressants in a patient with refractory major depression.
abstract: Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant depression and modest and transient response to ECT and who showed a robust and maintained response after six i.v. ketamine (0.5 mg/kg) infusions without withdrawing her antidepressant regimen. Ketamine was very well tolerated. This case illustrates the potential role of ketamine as a booster to standard antidepressants.
authors.affiliation: Psychiatry Service, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, CIBERSAM, IRYCIS, Carretera Colmenar km. 9.1, 28034 Madrid, Spain.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Montes
authors.affiliation: Psychiatry Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Luján
authors.affiliation: Psychiatry Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain.
authors.forename: Fernado
authors.initials: F
authors.lastname: Pascual
authors.affiliation: Anaesthesiology Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain.
authors.forename: Jose María
authors.initials: JM
authors.lastname: Beleña
authors.affiliation: Anaesthesiology Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Perez-Santar
authors.affiliation: Psychiatry Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain.
authors.forename: Luis Javier
authors.initials: LJ
authors.lastname: Irastorza
authors.affiliation: Psychiatry Service, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, CIBERSAM, IRYCIS, Carretera Colmenar km. 9.1, 28034 Madrid, Spain.
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Saiz-Ruiz
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