title: 18F-FDG activitiy PET/CT and CA-19.9 levels for the prediction of histopathological features and localization of peri- ampullary tumors.
abstract: OBJECTIVE
  We sought to investigate the roles of maximum standardized uptake value (SUVmax) and serum carbohydrate antigen 19-9 (CA 19-9) in predicting the histopathological features of periampullary tumors.
  
  
  METHODS
  Thirty-four patients with histologically confirmed periampullary tumors were classified into two groups, according to the localizations of their tumors (ampulla Vateri or pancreas). SUVmax was obtained from [(18)F]-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT). SUVmax and CA 19-9 levels were measured and compared with histopathological features of the tumors. Logistic regression was used to assess the significance and independence of predictive factors.
  
  
  RESULTS
  18F-FDG PET/CT SUVmax (<2.5 vs. ≥2.5; p=0.031) and CA 19-9 level (normal vs. elevated; p=0.045) were significantly and independently predictive of the histopathological origin of the tumors (ampulla Vateri vs. pancreas). The ratio of CA 19-9 levels and SUVmax were found to be higher in cases of poorly differentiated tumors and tumors greater than 2 cm in diameter.
  
  
  CONCLUSIONS
  A surgical approach to treatment may be considered for patients who have both i) an established or suspected diagnosis of periampullary tumors and ii) low SUVmax and CA 19-9 levels.
authors.affiliation: Department of General Surgery, Çukurova University Faculty of Pharmacy, Adana, Turkey. disciple951@gmail.com.
authors.forename: Atilgan Tolga
authors.initials: AT
authors.lastname: Akcam
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ülkü
authors.forename: Ahmet
authors.initials: A
authors.lastname: Rencuzoğulları
authors.forename: Cem Kaan
authors.initials: CK
authors.lastname: Parsak
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Yapar
authors.forename: Figen
authors.initials: F
authors.lastname: Doran
authors.forename: Haluk
authors.initials: H
authors.lastname: Demiryürek
authors.forename: Alexis Kofi
authors.initials: AK
authors.lastname: Okoh
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology; D018395:CA-19-9 Antigen / Q000097:blood*; D003138:Common Bile Duct Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D004379:Duodenal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed
chemical_list: D018395:CA-19-9 Antigen; D019788:Fluorodeoxyglucose F18