title: [Biotherapy targeting the immune system].
abstract: The use of monoclonal antibody targeted therapy has changed the management of several diseases, including in hematology and immunology. The panel of the present available biotherapies allows a specific action at various stages of the immune response. Indeed, some of these molecules can target the naive T cell at the immunological synapse or the way of TH1, TH17 and regulatory T cell. Others may be more specific for the B cell and immunoglobulin. Some will even be active on both B and T cells.
authors.forename: Laurent
authors.initials: L
authors.lastname: Frenzel
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000628:therapy; D001691:Biological Therapy / Q000379:methods*; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000503:physiopathology; D054992:Immunological Synapses / Q000187:drug effects; D056747:Immunomodulation; D058990:Molecular Targeted Therapy; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000961:Antilymphocyte Serum