title: A pentose bisphosphate pathway for nucleoside degradation in Archaea.
abstract: Owing to the absence of the pentose phosphate pathway, the degradation pathway for the ribose moieties of nucleosides is unknown in Archaea. Here, in the archaeon Thermococcus kodakarensis, we identified a metabolic network that links the pentose moieties of nucleosides or nucleotides to central carbon metabolism. The network consists of three nucleoside phosphorylases, an ADP-dependent ribose-1-phosphate kinase and two enzymes of a previously identified NMP degradation pathway, ribose-1,5-bisphosphate isomerase and type III ribulose-1,5-bisphosphate carboxylase/oxygenase. Ribose 1,5-bisphosphate and ribulose 1,5-bisphosphate are intermediates of this pathway, which is thus designated the pentose bisphosphate pathway.
authors.affiliation: 1] Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. [2] Japan Society for the Promotion of Science, Tokyo, Japan.
authors.forename: Riku
authors.initials: R
authors.lastname: Aono
authors.affiliation: 1] Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. [2] Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Tokyo, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sato
authors.affiliation: 1] Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Tokyo, Japan. [2] Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kyoto, Japan.
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Imanaka
authors.affiliation: 1] Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan. [2] Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology, Tokyo, Japan.
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Atomi
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D019747:Aldose-Ketose Isomerases / Q000187:drug effects / Q000378:metabolism; D001105:Archaea / Q000378:metabolism*; D019843:Archaeal Proteins / Q000187:drug effects / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005822:Genetic Vectors; D009705:Nucleosides / Q000378:metabolism*; D010427:Pentose Phosphate Pathway / Q000235:genetics / Q000502:physiology*; D010428:Pentosephosphates / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D012273:Ribulose-Bisphosphate Carboxylase; D019712:Thermococcus / Q000235:genetics / Q000378:metabolism*; D014541:Uridine Kinase / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D009705:Nucleosides; D010428:Pentosephosphates; C050562:ribose-1,5-bisphosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D014541:Uridine Kinase; D012273:Ribulose-Bisphosphate Carboxylase; D019747:Aldose-Ketose Isomerases; C578203:ribose-1,5-bisphosphate isomerase, Thermococcus kodakarensis
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