title: Cell fate commitment during mammalian sex determination.
abstract: The gonads form bilaterally as bipotential organs that can develop as testes or ovaries. All secondary sex characteristics that we associate with 'maleness' or 'femaleness' depend on whether testes or ovaries form. The fate of the gonads depends on a cell fate decision that occurs in a somatic cell referred to as the 'supporting cell lineage'. Once supporting cell progenitors commit to Sertoli (male) or granulosa (female) fate, they propagate this decision to the other cells within the organ. In this review, we will describe what is known about the bipotential state of somatic and germ cell lineages in the gonad and the transcriptional and antagonistic signaling networks that lead to commitment, propagation, and maintenance of testis or ovary fate.
authors.affiliation: Department of Cell Biology, Duke University, Durham, NC 27710, USA.
authors.forename: Yi-Tzu
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Department of Cell Biology, Duke University, Durham, NC 27710, USA. Electronic address: blanche.capel@duke.edu.
authors.forename: Blanche
authors.initials: B
authors.lastname: Capel
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D005854:Germ Cells / Q000502:physiology*; D006066:Gonads / Q000196:embryology*; D006801:Humans; D008297:Male; D008322:Mammals / Q000196:embryology*; D008954:Models, Biological; D038081:Organogenesis / Q000502:physiology*; D019849:Sex Determination Processes / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D014157:Transcription Factors
references.citation: Cell. 2001 Mar 23;104(6):875-89
references.pmid: 11290325
references.citation: Hum Mol Genet. 2007 Dec 1;16(23):2795-804
references.pmid: 17728319
references.citation: Genes Dev. 2008 Feb 15;22(4):430-5
references.pmid: 18281459
references.citation: Development. 2002 Mar;129(5):1155-64
references.pmid: 11874911
references.citation: Development. 2000 Jan;127(1):65-73
references.pmid: 10654601
references.citation: Dev Dyn. 2008 Dec;237(12):3672-80
references.pmid: 18985752
references.citation: Cell. 2009 Dec 11;139(6):1130-42
references.pmid: 20005806
references.citation: PLoS Genet. 2013;9(7):e1003629
references.pmid: 23874227
references.citation: Dev Cell. 2010 Sep 14;19(3):440-9
references.pmid: 20833365
references.citation: Development. 2011 Jan;138(1):23-32
references.pmid: 21115610
references.citation: PLoS One. 2012;7(10):e47238
references.pmid: 23091613
references.citation: Endocrinology. 2012 Feb;153(2):913-24
references.pmid: 22186409
references.citation: Development. 2012 May;139(9):1577-86
references.pmid: 22438569
references.citation: Ciba Found Symp. 1994;182:157-68; discussion 168-78
references.pmid: 7835148
references.citation: Development. 2004 Aug;131(16):4095-105
references.pmid: 15289436
references.citation: PLoS Biol. 2006 Jun;4(6):e187
references.pmid: 16700629
references.citation: EMBO J. 2005 May 18;24(10):1798-809
references.pmid: 15889150
references.citation: Nature. 2000 Feb 24;403(6772):909-13
references.pmid: 10706291
references.citation: Development. 2008 Nov;135(22):3731-43
references.pmid: 18927154
references.citation: Biol Open. 2014 Nov 21;3(12):1207-16
references.pmid: 25416063
references.citation: Development. 2003 Dec;130(24):5895-902
references.pmid: 14561636
references.citation: Genes Dev. 2003 Mar 15;17(6):800-10
references.pmid: 12651897
references.citation: Development. 2010 Jan;137(2):303-12
references.pmid: 20040496
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9
references.pmid: 17038506
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3594-9
references.pmid: 20133598
references.citation: Hum Mol Genet. 2009 Feb 1;18(3):405-17
references.pmid: 18981061
references.citation: Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16061-6
references.pmid: 24043772
references.citation: Development. 2006 Apr;133(8):1519-27
references.pmid: 16540514
references.citation: PLoS Genet. 2012;8(12):e1003170
references.pmid: 23300469
references.citation: Mech Dev. 2009 May-Jun;126(5-6):324-36
references.pmid: 19269320
references.citation: Dev Cell. 2013 Aug 26;26(4):416-30
references.pmid: 23987514
references.citation: Methods Mol Biol. 2012;825:211-21
references.pmid: 22144247
references.citation: Dev Dyn. 2001 Jun;221(2):201-5
references.pmid: 11376487
references.citation: Biol Reprod. 2013 Apr;88(4):91
references.pmid: 23467742
references.citation: J Cell Sci. 2010 Mar 15;123(Pt 6):871-80
references.pmid: 20159962
references.citation: Dev Cell. 2014 Jun 9;29(5):511-20
references.pmid: 24856513
references.citation: Science. 1999 Dec 17;286(5448):2328-31
references.pmid: 10600740
references.citation: Cell. 2007 Dec 28;131(7):1273-86
references.pmid: 18155131
references.citation: PLoS One. 2010;5(4):e10382
references.pmid: 20454446
references.citation: Genes Dev. 2002 Jun 1;16(11):1433-40
references.pmid: 12050120
references.citation: Hum Mol Genet. 2008 Oct 1;17(19):2949-55
references.pmid: 18617533
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16558-63
references.pmid: 17940049
references.citation: Cell. 1994 May 20;77(4):481-90
references.pmid: 8187173
references.citation: Development. 1988 Dec;104(4):683-8
references.pmid: 3268409
references.citation: Genetics. 2003 May;164(1):277-88
references.pmid: 12750339
references.citation: PLoS Genet. 2012;8(3):e1002575
references.pmid: 22438826
references.citation: Development. 2009 Jan;136(1):129-38
references.pmid: 19036799
references.citation: Dev Biol. 2005 Nov 1;287(1):111-24
references.pmid: 16185683
references.citation: PLoS Genet. 2013;9(7):e1003630
references.pmid: 23874228
references.citation: Development. 2006 Apr;133(8):1495-505
references.pmid: 16540512
references.citation: Dev Biol. 1997 Jul 1;187(1):107-13
references.pmid: 9224678
references.citation: Endocrinology. 2011 Jan;152(1):272-80
references.pmid: 21084449
references.citation: Mol Reprod Dev. 1993 Jan;34(1):47-52
references.pmid: 8418816
references.citation: Development. 2009 Jun;136(11):1813-21
references.pmid: 19429785
references.citation: Endocrinology. 2010 Dec;151(12):5893-904
references.pmid: 20962046
references.citation: Development. 2014 Jun;141(11):2195-205
references.pmid: 24866114
references.citation: Fish Physiol Biochem. 2013 Feb;39(1):33-8
references.pmid: 22411079
references.citation: Endocrinology. 2007 Oct;148(10):4560-7
references.pmid: 17584971
references.citation: Sex Dev. 2013;7(1-3):147-62
references.pmid: 22626995
references.citation: Dev Biol. 2009 Apr 15;328(2):377-83
references.pmid: 19389346
references.citation: FASEB J. 2002 Sep;16(11):1389-97
references.pmid: 12205030
references.citation: Hum Mol Genet. 2008 May 1;17(9):1278-91
references.pmid: 18250097
references.citation: Dev Biol. 2007 Jan 1;301(1):38-52
references.pmid: 17141210
references.citation: Biol Reprod. 2013 Aug;89(2):34
references.pmid: 23843232
references.citation: Dev Biol. 1998 Nov 15;203(2):323-33
references.pmid: 9808783
references.citation: Dev Biol. 2005 Nov 15;287(2):361-77
references.pmid: 16214126
references.citation: Dev Biol. 1975 May;44(1):1-21
references.pmid: 1132581
references.citation: J Cell Biol. 2004 Oct 25;167(2):339-49
references.pmid: 15492040
references.citation: Cell. 2001 Aug 10;106(3):319-29
references.pmid: 11509181
references.citation: Dev Biol. 2003 Oct 15;262(2):303-12
references.pmid: 14550793
references.citation: Biol Reprod. 2006 Mar;74(3):450-8
references.pmid: 16339043
references.citation: Dev Biol. 2012 Oct 1;370(1):24-32
references.pmid: 22705479
references.citation: Dev Biol. 2011 Apr 1;352(1):14-26
references.pmid: 21255566
references.citation: Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):167-72
references.pmid: 21173261
references.citation: Gene Expr Patterns. 2007 Jan;7(1-2):113-23
references.pmid: 16839824
references.citation: PLoS One. 2011;6(1):e16366
references.pmid: 21297984
references.citation: Dev Biol. 2003 Oct 1;262(1):1-15
references.pmid: 14512014
references.citation: Gen Comp Endocrinol. 1997 Oct;108(1):87-101
references.pmid: 9378277
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2474-9
references.pmid: 16461896
references.citation: Curr Biol. 2014 Feb 17;24(4):404-8
references.pmid: 24485832
references.citation: Dev Biol. 2003 Jun 15;258(2):264-76
references.pmid: 12798287
references.citation: Hum Mol Genet. 2008 May 1;17(9):1264-77
references.pmid: 18250098
references.citation: Nature. 1998 Jun 18;393(6686):688-92
references.pmid: 9641679
references.citation: Mol Reprod Dev. 2004 Aug;68(4):422-8
references.pmid: 15236325
references.citation: Biol Reprod. 2001 Nov;65(5):1392-402
references.pmid: 11673255
references.citation: PLoS One. 2011;6(10):e25641
references.pmid: 21991325
references.citation: Stem Cells. 2008 Feb;26(2):339-47
references.pmid: 18024419
references.citation: Science. 2006 Apr 28;312(5773):596-600
references.pmid: 16574820
references.citation: J Biol Chem. 2007 Apr 6;282(14):10553-60
references.pmid: 17277314
references.citation: Mol Reprod Dev. 2007 Jul;74(7):912-21
references.pmid: 17219433
references.citation: Nature. 2013 Mar 14;495(7440):236-40
references.pmid: 23486062
references.citation: Int J Dev Biol. 2013;57(2-4):201-10
references.pmid: 23784831
references.citation: Nature. 1999 Feb 4;397(6718):405-9
references.pmid: 9989404
references.citation: Dev Biol. 1999 Dec 1;216(1):182-94
references.pmid: 10588871
references.citation: Sex Dev. 2011;5(6):304-17
references.pmid: 22116255
references.citation: Dev Biol. 2014 Oct 15;394(2):242-52
references.pmid: 25158167
references.citation: PLoS One. 2014;9(6):e100447
references.pmid: 24956260
references.citation: Dev Biol. 2013 Nov 15;383(2):295-306
references.pmid: 24036309
references.citation: Development. 2006 Sep;133(17):3411-8
references.pmid: 16887828
references.citation: Development. 1991 May;112(1):265-8
references.pmid: 1769333
references.citation: Nature. 1991 May 9;351(6322):117-21
references.pmid: 2030730
references.citation: Development. 1995 Jun;121(6):1603-14
references.pmid: 7600978
references.citation: Biol Reprod. 2012 Feb;86(2):37
references.pmid: 21976597
references.citation: Dev Biol. 2008 Feb 1;314(1):71-83
references.pmid: 18155190