title: Patterning, specification, and differentiation in the developing hypothalamus.
abstract: Owing to its complex structure and highly diverse cell populations, the study of hypothalamic development has historically lagged behind that of other brain regions. However, in recent years, a greatly expanded understanding of hypothalamic gene expression during development has opened up new avenues of investigation. In this review, we synthesize existing work to present a holistic picture of hypothalamic development from early induction and patterning through nuclear specification and differentiation, with a particular emphasis on determination of cell fate. We will also touch on special topics in the field including the prosomere model, adult neurogenesis, and integration of migratory cells originating outside the hypothalamic neuroepithelium, and how these topics relate to our broader theme.
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Bedont
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Newman
authors.affiliation: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|High-Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.|Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Blackshaw
mesh_terms: D000818:Animals; D019521:Body Patterning; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007031:Hypothalamus / Q000196:embryology* / Q000378:metabolism; D015398:Signal Transduction
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