title: Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer.
abstract: OBJECTIVE
  To determine the clinicopathologic characteristics of surgically treated ulcerative colitis (UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer (CAC) to those without CAC.
  
  
  METHODS
  Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without CAC.
  
  
  RESULTS
  Among 415 UC patients, 383 (92.2%) underwent total proctocolectomy, and of these, 342 (89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients (11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy (P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-year overall survival rate was 82.2%.
  
  
  CONCLUSIONS
  Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Yong Sik
authors.initials: YS
authors.lastname: Yoon
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Cho
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Kyu Joo
authors.initials: KJ
authors.lastname: Park
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Seung Hyuk
authors.initials: SH
authors.lastname: Baik
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Sang Nam
authors.initials: SN
authors.lastname: Yoon
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Seung-Bum
authors.initials: SB
authors.lastname: Ryoo
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Kil Yeon
authors.initials: KY
authors.lastname: Lee
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Hungdai
authors.initials: H
authors.lastname: Kim
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Ryung-Ah
authors.initials: RA
authors.lastname: Lee
authors.affiliation: Yong Sik Yoon, Chang Sik Yu, Department of Colon and Rectal Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul 138-736, South Korea.
authors.forename: Chang Sik
authors.initials: CS
authors.lastname: Yu
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects / Q000401:mortality; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D013256:Steroids / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D013256:Steroids
keywords: Colorectal neoplasms; Colorectal surgery; Inflammatory bowel disease; Survival; Ulcerative colitis
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