title: Factors that affect adverse drug reaction reporting among hospital pharmacists in Western China.
abstract: BACKGROUND
  Hospital pharmacists can make a considerable contribution to the spontaneous reporting system of adverse drug reactions. The factors that influence adverse drug reaction reporting among hospital pharmacists remain largely unknown in China.
  
  
  OBJECTIVE
  This study aims to identify factors that affect hospital pharmacist-led adverse drug reaction reporting in Xi'an, and to obtain suggestions from pharmacists about how to improve the current adverse drug reaction reporting system.
  
  
  METHODS
  Hospital settings throughout Xi'an, a region of Western China.
  
  
  METHODS
  A matched case-control study was conducted on a population of 2,814 hospital pharmacists in Xi'an during 2011. Cases included all pharmacists who had reported at least one adverse drug reaction between 2008 and 2010 and agreed to participate in the study (186/204; 91.2 %); controls (n = 372) were pharmacists who had not reported any adverse drug reaction during the same period. A self-administered questionnaire was distributed to the participants. Logistic regression was performed to evaluate the association between indicator variables and the outcome of having reported at least one adverse drug reaction.
  
  
  METHODS
  Pharmacists' knowledge, attitude and practice towards adverse drug reaction reporting and factors affecting reporting.
  
  
  RESULTS
  Higher professional title (adjusted OR 1.44; 95 % CI 1.07-1.94; p = 0.018), having received training about adverse drug reaction reporting (1.64; 1.04-2.57; p = 0.032), better knowledge about reporting (1.53; 1.12-2.08; p = 0.007), "lack of access to adverse drug reaction reporting form" (0.29; 0.12-0.72; p = 0.008) was independently associated with adverse drug reaction reporting. Clinical pharmacists were more likely to report an adverse drug reaction than dispensary pharmacists (1/adjusted OR 5.26; p < 0.001), pharmacy administrators (5.00; p = 0.003), and other technicians (5.56; p = 0.001).
  
  
  CONCLUSIONS
  Higher professional title, having received training, mastering knowledge about reporting, and being a clinical pharmacist were positive predictors of pharmacist-led adverse drug reaction reporting. Lack of access to reporting forms was a negative predictor. Continuous training and establishing incentive mechanisms are needed to promote adverse drug reaction reporting among hospital pharmacists.
authors.affiliation: Department of Pharmacy Administration, School of Pharmacy, Health Science Center, Xi'an Jiaotong University, 76 Yanta West Road, Xi'an, 710061, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Zhongliang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Shimin
authors.initials: S
authors.lastname: Yang
authors.forename: Bianling
authors.initials: B
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Haiyan
authors.initials: H
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D016022:Case-Control Studies; D002681:China; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008297:Male; D010595:Pharmacists / Q000523:psychology* / Q000706:statistics & numerical data*; D010607:Pharmacy Service, Hospital / Q000706:statistics & numerical data*
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