title: Evaluation of medicinal interventions for the management of oral submucous fibrosis: a systematic review of the literature.
abstract: Oral submucous fibrosis is a chronic, progressive scarring disease associated with both significant morbidity including pain and limited mouth opening and an increased risk for malignancy. This systematic review evaluated the different medicinal (i.e. nonsurgical) interventions available for the management of oral submucous fibrosis. An automated literature searches of online databases from January 1960 to December 2013 were performed and only studies with high level of evidence based on the guidelines of the Oxford Centre for evidence-based medicine were selected. Thirteen studies (3 randomized controlled trials and 10 clinical trials/controlled clinical trials) were included and drugs like steroids, hyaluronidase, human placenta extracts, chymotrypsin and collagenase, pentoxifylline, nylidrin hydrochloride, iron and multivitamin supplements including lycopene were used. There is a clear lack of evidence on the available drug treatment for oral submucous fibrosis and further high quality randomized controlled trials are needed to evaluate the different therapeutic agents.
authors.affiliation: Assistant Professor, Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh Saudi Arabia, Phone: +966 1 467-7422, Fax: 966 1 467-9018 e-mail: kamranhabibawan@gmail.com.
authors.forename: Kamran Habib
authors.initials: KH
authors.lastname: Awan
authors.affiliation: Associate Professor, Department of Oral Pathology, Faculty of Dental Sciences MS Ramaiah University of Applied Sciences, Bengaluru Karnataka, India.
authors.forename: Shankargouda
authors.initials: S
authors.lastname: Patil
authors.affiliation: Assistant Professor, Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Syed Rashid
authors.initials: SR
authors.lastname: Habib
authors.affiliation: Assistant Professor, Department of Periodontology and Oral Medicine, Medical Faculty, University of Nis, Nis, Serbia.
authors.forename: Ana
authors.initials: A
authors.lastname: Pejcic
authors.affiliation: Professor, Department of Oral and Maxillofacial Surgical and Medical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Rosnah Binti
authors.initials: RB
authors.lastname: Zain
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D057487:Enzyme Therapy; D006801:Humans; D009914:Oral Submucous Fibrosis / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000975:Antioxidants; D014665:Vasodilator Agents
keywords: Drugs; Habib SR; Oral submucous fibrosis; Patil S; Pejcic A; Steroids; Systematic review; Treatment. How to cite this article: Awan KH; Zain RB. Evaluation of Medicinal Interventions for the Management of Oral Submucous Fibrosis: A Systematic Review of the Literature. J Contemp Dent Pract 2014;15(6):812-817. Source of support: Nil Conflict of interest: None.