title: [Structural reorganization of the dermis of dog tibia during its elongation by the method of transosseous distraction osteosynthesis].
abstract: Using the methods of light, scanning and transmission electron microscopy, immunohistochemistry and morphometry the status of the various components of the dermis was studied in the experiment performed on 16 adult mongrel dogs that had their shank extended by 17% of its original length using the method of transosseous distraction osteosynthesis with a daily rate of 1 mm for 4 steps. During the period of distraction, a reduction in the thickness of the dermis, change of the architectonics of its fibrous component, active collageno- and elastogenesis, cell proliferation, and the expressiveness of heteromorphism of fibroblast and macrophage cell populations were detected. In postdistraction period, all the indices were gradually approaching the norm. The data obtained may serve as criteria for the estimation of the stages of the reparative process developing under the created conditions and should be considered in the development of new technologies aimed at optimizing reparative-regenerative processes during tibial lengthening.
authors.forename: Ye N
authors.initials: YN
authors.lastname: Gorbach
mesh_terms: D000818:Animals; D003094:Collagen / Q000235:genetics / Q000378:metabolism; D020405:Dermis / Q000166:cytology* / Q000378:metabolism / Q000601:surgery; D004285:Dogs; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D018889:Ilizarov Technique; D008264:Macrophages / Q000378:metabolism; D019857:Osteogenesis, Distraction; D013977:Tibia / Q000166:cytology / Q000378:metabolism / Q000601:surgery*
chemical_list: D003094:Collagen