title: Placental deposition of C-reactive protein is a common feature of human pregnancy.
abstract: This study examined the occurrence of placental C-reactive protein (CRP) in normal pregnancy with term delivery, spontaneous preterm delivery (sPTD), preeclampsia, and miscarriage. CRP immunoreactivity was detected in the syncytiotrophoblast. The immunopositive rate was significantly higher in sPTD than preeclampsia. The CRP immunopositive rate was also higher in acute chorioamnionitis than those without and showed a good correlation with the maternal serum CRP concentration. CRP mRNA expression was not detected in human and mouse placentas or choriocarcinoma cells. CRP may play a role in the pathological and physiological states of pregnancy.
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: E N
authors.initials: EN
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: B H
authors.initials: BH
authors.lastname: Yoon
authors.affiliation: Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: E J
authors.initials: EJ
authors.lastname: Jeon
authors.affiliation: Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
authors.forename: J B
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea.
authors.forename: J-S
authors.initials: JS
authors.lastname: Hong
authors.affiliation: Hamchoon Women's Clinic, Seoul, Republic of Korea.
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Hamchoon Women's Clinic, Seoul, Republic of Korea.
authors.forename: D
authors.initials: D
authors.lastname: Hwang
authors.affiliation: Hamchoon Women's Clinic, Seoul, Republic of Korea.
authors.forename: K C
authors.initials: KC
authors.lastname: Kim
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: J-S
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea; Asan Laboratory of Perinatal Science, Asan Medical Center, Seoul, Republic of Korea. Electronic address: ckim@amc.seoul.kr.
authors.forename: C J
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000022:Abortion, Spontaneous / Q000378:metabolism; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D051379:Mice; D007752:Obstetric Labor, Premature / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism*
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; Immunohistochemistry; Placenta; Trophoblast