title: Comparison of the efficacy of different types of lasers for the treatment of peri-implantitis: a systematic review.
abstract: OBJECTIVE
  To evaluate the efficacy of various types of lasers (neodymium-doped yttrium-aluminum-garnet [Nd:YAG], carbon dioxide [CO2], diode, erbium/chromium-doped yttrium-scandium-gallium-garnet [Er,Cr:YSGG], and erbium-doped yttrium-aluminum-garnet [Er:YAG]) in the treatment of peri-implantitis and their use in surgical and nonsurgical procedures.
  
  
  METHODS
  Human studies for the treatment of peri-implantitis with laser therapy, published between 2002 and January 2014, were collected utilizing the electronic databases PubMed, Ovid, MEDLINE, Cochrane, and Google Scholar. Two reviewers conducted the study selection, data collection, and validity assessment.
  
  
  RESULTS
  Eight hundred twelve studies were selected in the initial title search; 13 studies were then chosen for this review. No human studies evaluated the effect of the Nd:YAG laser on peri-implantitis. The CO2 laser is reported to be safe and able to enhance bone regeneration. The diode laser (980 nm) seems to be effective in its bactericidal effect without changing the implant surface pattern. The Er,Cr:YSGG laser was reported to obtain bone regeneration around a failing implant in one case, while the Er:YAG laser exhibits a strong bactericidal effect against periodontopathic bacteria at a low energy level.
  
  
  CONCLUSIONS
  Although lasers have shown promising results in reducing clinical signs of peri-implantitis, because of the limited sample sizes and short follow-up periods, no firm conclusion can be drawn at this moment. Hence, there is a need for more well-designed, longitudinal, randomized controlled clinical trials.
authors.forename: Zuhair S
authors.initials: ZS
authors.lastname: Natto
authors.forename: Majdi
authors.initials: M
authors.lastname: Aladmawy
authors.forename: Paul A
authors.initials: PA
authors.lastname: Levi
authors.forename: Hom-Lay
authors.initials: HL
authors.lastname: Wang
mesh_terms: D000535:Aluminum; D001419:Bacteria / Q000528:radiation effects; D001861:Bone Regeneration; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D007834:Lasers; D054020:Lasers, Gas / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D057873:Peri-Implantitis / Q000532:radiotherapy*; D015019:Yttrium
chemical_list: C503779:yttrium-aluminum-garnet; D015019:Yttrium; D000535:Aluminum