title: Long-term dynamics of gastric biomarkers after eradication of Helicobacter pylori infection.
abstract: BACKGROUND
  Secretion of pepsinogen I (PgI), pepsinogen II (PgII), fasting gastrin-17 (fG-17) and stimulated gastrin-17 (sG-17) changes after Helicobacter pylori eradication. Few data are available on the long-term dynamics of gastric biomarkers after H. pylori eradication.The aim of this study was to investigate the dynamics of gastric biomarkers in H. pylori-positive patients after eradication over a 3-year period and to compare the levels with initially H. pylori-negative patients.
  
  
  METHODS
  Blood samples for the detection of gastric biomarkers were obtained from dyspeptic patients coming for upper gastrointestinal endoscopy. In H. pylori-positive patients, after eradication therapy, three follow-up blood samples were drawn after 12, 24 and 36 months; in H. pylori-negative patients, two samples were taken - at 12 and after 30 months. Median values of biomarkers in follow-up samples were compared with the baseline sample.
  
  
  RESULTS
  The final sample included 110 patients (median age 67 years, M/F ratio 27/83). In patients after H. pylori eradication (n=83) PgI, PgII, fG-17 and sG-17 had decreased significantly during a 36-month period, whereas the PgI/PgII ratio had increased significantly from 5.59 to 11.64.
  
  
  CONCLUSIONS
  In H. pylori-positive dyspeptic patients, after eradication therapy, a decrease in PgI, PgII, fG-17 and sG-17 was observed after 36 months whereas an increase in the PgI/II ratio suggested an improvement in gastric atrophy. The median levels of gastric biomarkers in patients after H. pylori eradication therapy may become similar to biomarker levels among initially H. pylori-negative individuals.
authors.affiliation: aFaculty of Medicine, University of Latvia bDigestive Diseases Centre GASTRO, Faculty of Medicine, University of Latvia, Riga East University Hospital, Riga, Latvia cFaculty of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Ilva
authors.initials: I
authors.lastname: Daugule
authors.forename: Agnese
authors.initials: A
authors.lastname: Ruskule
authors.forename: Georgijs
authors.initials: G
authors.lastname: Moisejevs
authors.forename: Dace
authors.initials: D
authors.lastname: Rudzite
authors.forename: Laimas
authors.initials: L
authors.lastname: Jonaitis
authors.forename: Dainius
authors.initials: D
authors.lastname: Janciauskas
authors.forename: Gediminas
authors.initials: G
authors.lastname: Kiudelis
authors.forename: Limas
authors.initials: L
authors.lastname: Kupcinskas
authors.forename: Marcis
authors.initials: M
authors.lastname: Leja
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D004415:Dyspepsia / Q000097:blood / Q000382:microbiology; D016099:Endoscopy, Gastrointestinal; D005215:Fasting; D005260:Female; D005500:Follow-Up Studies; D005755:Gastrins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D005755:Gastrins; C013550:gastrin 17; D020115:Pepsinogen C; D020116:Pepsinogen A