title: Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012-2013.
abstract: An explosive epidemic occurred in Madeira Island (Portugal) from October 2012 to February 2013. Published data showed that dengue virus type 1 introduced from South America was the incriminated virus. We aim to determine the origin of the strain introduced to Madeira by travellers returning to Europe. Using phylogeographic analysis and complete envelope sequences we have demonstrated that the most probable origin of the strain is Venezuela.
authors.affiliation: National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain. Electronic address: francolet@isciii.es.
authors.forename: L
authors.initials: L
authors.lastname: Franco
authors.affiliation: Centro de Biotecnología y Genómica de Plantas (UPM-INIA), Pozuelo de Alarcón, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Pagan
authors.affiliation: Centro de Asistencia Primaria Drassanes, Institut Català de la Salut, Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Serre Del Cor
authors.affiliation: Department of Infectious Diseases & Tropical Medicine, University of Munich, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schunk
authors.affiliation: Medical and Diagnostic Service Department, Swiss Tropical and Public Health Institute, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Neumayr
authors.affiliation: National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Molero
authors.affiliation: National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Potente
authors.affiliation: Medical and Diagnostic Service Department, Swiss Tropical and Public Health Institute, Basel, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Hatz
authors.affiliation: Department of Public Health and Clinical Medicine, Epidemiology and Global Health, Umeå University, Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Wilder-Smith
authors.affiliation: National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: Sánchez-Seco
authors.affiliation: National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Tenorio
mesh_terms: D016000:Cluster Analysis; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D004196:Disease Outbreaks; D015686:Gene Products, env / Q000235:genetics; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D058974:Phylogeography; D011174:Portugal / Q000453:epidemiology; D017422:Sequence Analysis, DNA; D014687:Venezuela / Q000453:epidemiology
chemical_list: D015686:Gene Products, env
keywords: Dengue fever; Madeira; South America; dengue virus 1; travel infection