title: Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.
abstract: Familial inheritance of drug abuse is composed of both genetic and environmental factors. Additionally, epigenetic transgenerational inheritance may provide a means by which parental drug use can influence several generations of offspring. Recent evidence suggests that parental drug exposure produces behavioral, biochemical, and neuroanatomical changes in future generations. The focus of this review is to discuss these multigenerational and transgenerational phenotypes in the offspring of animals exposed to drugs of abuse. Specifically, changes found following the administration of alcohol, opioids, cocaine, marijuana, and nicotine will be discussed. In addition, epigenetic modifications to the genome following administration of these drugs will be detailed as well as their potential for transmission to the next generation.
authors.affiliation: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Yohn
authors.affiliation: Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Marisa S
authors.initials: MS
authors.lastname: Bartolomei
authors.affiliation: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: blendy@mail.med.upenn.edu.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Blendy
mesh_terms: D000438:Alcohols / Q000633:toxicity*; D000701:Analgesics, Opioid / Q000633:toxicity*; D000818:Animals; D002188:Cannabis / Q000633:toxicity*; D003042:Cocaine / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D040582:Inheritance Patterns; D009538:Nicotine / Q000633:toxicity*; D019966:Substance-Related Disorders / Q000235:genetics*
chemical_list: D000438:Alcohols; D000701:Analgesics, Opioid; D009538:Nicotine; D003042:Cocaine
keywords: Drug abuse; Epigenetic; Multigenerational; Transgenerational
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