title: Optomap ultrawide field imaging identifies additional retinal abnormalities in patients with diabetic retinopathy.
abstract: OBJECTIVE
  To compare diabetic retinopathy (DR) severity grading between Optomap ultrawide field scanning laser ophthalmoscope (UWFSLO) 200° images and an Early Treatment Diabetic Retinopathy Study (ETDRS) seven-standard field view.
  
  
  METHODS
  Optomap UWFSLO images (total: 266) were retrospectively selected for evidence of DR from a database of eye clinic attendees. The Optomap UWFSLO images were graded for DR severity by two masked assessors. An ETDRS seven-field mask was overlaid on the Optomap UWFSLO images, and the DR grade was assessed for the region inside the mask. Any interassessor discrepancies were adjudicated by a senior retinal specialist. Kappa agreement levels were used for statistical analysis.
  
  
  RESULTS
  Fifty images (19%) (P<0.001) were assigned a higher DR level in the Optomap UWFSLO view compared to the ETDRS seven-field view, which resulted in 40 images (15%) (P<0.001) receiving a higher DR severity grade. DR severity grades in the ETDRS seven-field view compared with the Optomap UWFSLO view were identical in 85% (226) of the images and within one severity level in 100% (266) of the images. Agreement between the two views was substantial: unweighted κ was 0.74±0.04 (95% confidence interval: 0.67-0.81) and weighted κ was 0.80±0.03 (95% confidence interval: 0.74-0.86).
  
  
  CONCLUSIONS
  Compared to the ETDRS seven-field view, a significant minority of patients are diagnosed with more severe DR when using the Optomap UWFSLO view. The clinical significance of additional peripheral lesions requires evaluation in future prospective studies using large cohorts.
authors.affiliation: Oxford Eye Hospital, University of Oxford, Oxford, UK.
authors.forename: Liam D
authors.initials: LD
authors.lastname: Price
authors.affiliation: University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Au
authors.affiliation: Oxford Eye Hospital, University of Oxford, Oxford, UK.
authors.forename: N Victor
authors.initials: NV
authors.lastname: Chong
keywords: diabetes; diagnostic imaging; retina
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