title: Brown Adipose Tissue Transplantation Reverses Obesity in Ob/Ob Mice.
abstract: Increasing evidence indicates that brown adipose tissue (BAT) transplantation enhances whole-body energy metabolism in a mouse model of diet-induced obesity. However, it remains unclear whether BAT also has such beneficial effects on genetically obese mice. To address this issue, we transplanted BAT from C57/BL6 mice into the dorsal subcutaneous region of age- and sex-matched leptin deficient Ob/Ob mice. Interestingly, BAT transplantation led to a significant reduction of body weight gain with increased oxygen consumption and decreased total body fat mass, resulting in improvement of insulin resistance and liver steatosis. In addition, BAT transplantation increased the level of circulating adiponectin, whereas it reduced the levels of circulating free T3 and T4, which regulate thyroid hormone sensitivity in peripheral tissues. BAT transplantation also increased β3-adrenergic receptor and fatty acid oxidation related gene expression in subcutaneous and epididymal (EP) white adipose tissue. Accordingly, BAT transplantation increased whole-body thermogenesis. Taken together our results demonstrate that BAT transplantation may reduce obesity and its related diseases by activating endogenous BAT.
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Siping
authors.initials: S
authors.lastname: Wang
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Yilin
authors.initials: Y
authors.lastname: You
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Minghui
authors.initials: M
authors.lastname: Meng
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Zongji
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Meng
authors.initials: M
authors.lastname: Dong
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Qianwei
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Lieqin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Dehua
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Zhan
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Hyuek
authors.initials: H
authors.lastname: Jong Lee
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: John R
authors.initials: JR
authors.lastname: Speakman
authors.affiliation: Key laboratory of Animal Ecology and Conservation Biology (X.L., M.M., M.D., J.L., Q.Z., X.Y., T.H., L.L., Y.H., L.Z., H.J.L., W.J.) and State Key Laboratory of Integrated Management of Pest Insects and Rodents (D.W.), Institute of Zoology, and State Key Laboratory of Molecular Developmental Biology (J.R.S.), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; The University of the Chinese Academy of Sciences (X.L., M.D., J.L., Q.Z., X.Y., T.H.), Beijing 100049, China; College of Life Sciences (X.L.), Zhoukou Normal University, Zhoukou, Henan 466001, China; Department of Special Service (S.W.), Chinese PLA General Hospital, and College of Food Science and Nutritional Engineering (Y.Y., J.Z.), China Agricultural University, Tsinghua, Haidian District, Beijing 100083, China; Department of Endocrinology and Metabolism (Z.Z.), Nanfang Hospital, Southern Medical University, Guangdong 53001, China; College of Animal Science and Technology (C.Z.), Nanjing Agricultural University, Nanjing 210095, China; and Institute of Biological and Environmental Science (J.R.S.), University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom.
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Jin
mesh_terms: D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue; D002001:Adipose Tissue, Brown / Q000637:transplantation*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism*; D015870:Gene Expression; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D020738:Leptin / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D010101:Oxygen Consumption; D012333:RNA, Messenger / Q000378:metabolism*; D022722:Thermogenesis; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism; D015430:Weight Gain
chemical_list: D052242:Adiponectin; D005227:Fatty Acids; D007328:Insulin; D020738:Leptin; D012333:RNA, Messenger; D014284:Triiodothyronine; D013974:Thyroxine